WorldWideScience

Sample records for astatine 201

  1. Astatine-211: production and availability.

    Science.gov (United States)

    Zalutsky, Michael R; Pruszynski, Marek

    2011-07-01

    The 7.2-h half life radiohalogen (211)At offers many potential advantages for targeted α-particle therapy; however, its use for this purpose is constrained by its limited availability. Astatine-211 can be produced in reasonable yield from natural bismuth targets via the (209)Bi(α,2n)(211)At nuclear reaction utilizing straightforward methods. There is some debate as to the best incident α-particle energy for maximizing 211At production while minimizing production of (210)At, which is problematic because of its 138.4-day half life α-particle emitting daughter, (210)Po. The intrinsic cost for producing (211)At is reasonably modest and comparable to that of commercially available (123)I. The major impediment to (211)At availability is attributed to the need for a medium energy α-particle beam for its production. On the other hand, there are about 30 cyclotrons in the world that have the beam characteristics required for (211)At production.

  2. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    CERN Document Server

    Rothe, S; Antalic, S; Borschevsky, A; Capponi, L; Cocolios, T E; De Witte, H; Eliav, E; Fedorov, D V; Fedosseev, V N; Fink, D A; Fritzsche, S; Ghys, L; Huyse, M; Imai, N; Kaldor, U; Kudryavtsev, Yu; Köster, U; Lane, J; Lassen, J; Liberati, V; Lynch, K M; Marsh, B A; Nishio, K; Pauwels, D; Pershina, V; Popescu, L; Procter, T J; Radulov, D; Raeder, S; Rajabali, M M; Rapisarda, E; Rossel, R E; Sandhu, K; Seliverstov, M D; Sjödin, A M; Van den Bergh, P; Van Duppen, P; Venhart, M; Wakabayashi, Y; Wendt K D A

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of smallest quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy required to remove one electron from the valence shell, referred to as the ionization potential. Here we use laser spectroscopy to probe the optical spectrum of astatine near the ionization threshold. The observed series of Rydberg states enabled the first determination of the ionization potential of the astatine atom, 9.317510(8) eV. New ab initio calculations were performed to support the experimental result. The measured value serves as a benchmark for quantum chemistry calculations of the properties of astatine as well as for the theoretical prediction of the ionization potential of super-heavy element 117, the heaviest homologue of astatine.

  3. Spectroscopy of low-lying states in neutron-deficient astatine and francium nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Jakobsson, U., E-mail: ulrjak@kth.se; Cederwall, B. [KTH, The Division of Nuclear Physics, AlbaNova University Center, SE-10691 Stockholm (Sweden); Uusitalo, J.; Auranen, K.; Badran, H.; Cox, D. M.; Grahn, T.; Greenlees, P. T.; Julin, R.; Juutinen, S.; Herzáň, A.; Konki, J.; Leino, M.; Mallaburn, M.; Pakarinen, J.; Papadakis, P.; Partanen, J.; Rahkila, P.; Sandzelius, M.; Sarén, J. [University of Jyvaskyla, Department of Physics, P.O. Box 35, FI-40014 University of Jyvaskyla (Finland); and others

    2015-10-15

    Low-lying states in neutron-deficient astatine and francium nuclei have been studied by means of in-beam and delayed spectroscopy. The 13/2{sup +} state has been observed in francium nuclei with a similar down-sloping trend as in neighbouring astatine and bismuth isotopes, as a function of decreasing neutron number. A systematic trend can also now be seen for the 1/2{sup +} state both in astatine and francium nuclei, where the level energy decreases steeply as a function of neutron number when moving further away from the neutron shell closure. This trend is very similar between astatine nuclei and their francium isotones. Moreover, shape coexistence has been observed between the 13/2{sup +} state and the spherical 9/2{sup −} ground state in {sup 203}Fr and {sup 205}Fr.

  4. Automated astatination of biomolecules - a stepping stone towards multicenter clinical trials

    DEFF Research Database (Denmark)

    Aneheim, Emma; Albertsson, Per; Bäck, Tom

    2015-01-01

    and physical properties for use in targeted therapies for cancer. Due to the very short range of the emitted α-particles, this therapy is particularly suited to treating occult, disseminated cancers. Astatine is not intrinsically tumour-specific; therefore, it requires an appropriate tumour-specific targeting......To facilitate multicentre clinical studies on targeted alpha therapy, it is necessary to develop an automated, on-site procedure for conjugating rare, short-lived, alpha-emitting radionuclides to biomolecules. Astatine-211 is one of the few alpha-emitting nuclides with appropriate chemical...

  5. Measurement of the first ionization potential of astatine by laser ionization spectroscopy

    NARCIS (Netherlands)

    Rothe, S.; Andreyev, A. N.; Antalic, S.; Borschevsky, A.; Capponi, L.; Cocolios, T. E.; De Witte, H.; Eliav, E.; Fedorov, D. V.; Fedosseev, V. N.; Fink, D. A.; Fritzsche, S.; Ghys, L.; Huyse, M.; Imai, N.; Kaldor, U.; Kudryavtsev, Yuri; Koester, U.; Lane, J. F. W.; Lassen, J.; Liberati, V.; Lynch, K. M.; Marsh, B. A.; Nishio, K.; Pauwels, D.; Pershina, V.; Popescu, L.; Procter, T. J.; Radulov, D.; Raeder, S.; Rajabali, M. M.; Rapisarda, E.; Rossel, R. E.; Sandhu, K.; Seliverstov, M. D.; Sjoedin, A. M.; Van den Bergh, P.; Van Duppen, P.; Venhart, M.; Wakabayashi, Y.; Wendt, K. D. A.

    2013-01-01

    The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviou

  6. Laser photodetachment of radioactive ions: towards the determination of the electronegativity of astatine

    CERN Multimedia

    Rothe, Sebastian; Welander, Jakob Emanuel; Chrysalidis, Katerina; Day Goodacre, Thomas; Fedosseev, Valentine; Fiotakis, Spyridon; Forstner, Oliver; Heinke, Reinhard Matthias; Johnston, Karl; Kron, Tobias; Koester, Ulli; Liu, Yuan; Marsh, Bruce; Ringvall Moberg, Annie; Rossel, Ralf Erik; Seiffert, Christoph; Studer, Dominik; Wendt, Klaus; Hanstorp, Dag

    2017-01-01

    Negatively charged ions are mainly stabilized through the electron correlation effect. A measure of the stability of a negative ion is the electron affinity, which the energy gain by attaching an electron to a neutral atom. This fundamental quantity is, due to the almost general lack of bound excited states, the only atomic property that can be determined with high accuracy for negative ions. We will present the results of the first laser photodetachment studies of radioactive negative ions at CERN-ISOLDE. The photodetachment threshold for the radiogenic iodine isotope 128I was measured successfully, demonstrating the performance of the upgraded GANDALPH experimental beam line. The first detection of photo-detached astatine atoms marks a milestone towards the determination of the EA of this radioactive element.

  7. Determination of the electron affinity of astatine and polonium by laser photodetachment

    CERN Multimedia

    We propose to conduct the first electron affinity (EA) measurements of the two elements astatine (At) and polonium (Po). Collinear photo-detachment spectroscopy will allow us to measure these quantities with an uncertainty limited only by the spectral line width of the laser. We plan to use negative ion beams of the two radioactive elements At and Po, which are only accessible on-line and at ISOLDE. The feasibility of our proposed method and the functionality of the experimental setup have been demonstrated at ISOLDE in off-line tests by the clear observation of the photo-detachment threshold for stable iodine. This proposal is based on our Letter of Intent I-148.

  8. Main: SAD201 [AT Atlas

    Lifescience Database Archive (English)

    Full Text Available SAD201 SAD2 Diversification of protein structural analysis technologies by the SAIL... method Diversification of protein structural analysis technologies by the SAIL method Masatsune Kainosho Graduate School of Science, Nagoya University SAD201.csml ...

  9. Ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and ionic radii of element Uus (Z = 117) and astatine.

    Science.gov (United States)

    Chang, Zhiwei; Li, Jiguang; Dong, Chenzhong

    2010-12-30

    Multiconfiguration Dirac-Fock (MCDF) method was employed to calculate the first five ionization potentials, electron affinities, resonance excitation energies, oscillator strengths, and radii for the element Uus and its homologue At. Main valence correlation effects were taken into account. The Breit interaction and QED effects were also estimated. The uncertainties of calculated IPs, EAs, and IR for Uus and At were reduced through an extrapolation procedure. The good consistency with available experimental and other theoretical values demonstrates the validity of the present results. These theoretical data therefore can be used to predict some unknown physicochemical properties of element Uus, Astatine, and their compounds.

  10. ASTATINE-211 RADIOCHEMISTRY: THE DEVELOPMENT OF METHODOLOGIES FOR HIGH ACTIVITY LEVEL RADIOSYNTHESIS

    Energy Technology Data Exchange (ETDEWEB)

    MICHAEL R. ZALUTSKY

    2012-08-08

    Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine radiochemistry: First, a well known characteristic of 211At chemistry is that yields for electrophilic astatination reactions decline as the time interval after radionuclide isolation from the cyclotron target increases. This is a critical problem that must be addressed if cyclotrons are to be able to efficiently supply 211At to remote users. And second, when the preparation of high levels of 211At-labeled compounds is attempted, the radiochemical yields can be considerably lower than those encountered at tracer dose. For these reasons, clinical evaluation of promising 211At

  11. An all-solid state laser system for the laser ion source RILIS and in-source laser spectroscopy of astatine at ISOLDE, CERN

    CERN Document Server

    Rothe, Sebastian; Nörtershäuser, W

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at ISOLDE, CERN, by the addition of an all-solid state tuneable titanium: sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE, CERN, and at ISAC, TRIUMF, radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  12. An all-solid state laser system for the laser ion sources RILIS and in-source laser spectroscopy of astatine at ISOLDE/CERN

    Energy Technology Data Exchange (ETDEWEB)

    Rothe, Sebastian

    2012-09-24

    This doctoral thesis describes the extension of the resonance ionization laser ion source RILIS at CERN/ISOLDE by the addition of an all-solid state tunable titanium:sapphire (Ti:Sa) laser system to complement the well-established system of dye lasers. Synchronous operation of the so called Dual RILIS system of Ti:Sa and dye lasers was investigated and the potential for increased ion beam intensity, reliability, and reduced setup time has been demonstrated. In-source resonance ionization spectroscopy was performed at ISOLDE/CERN and at ISAC/TRIUMF radioactive ion beam facilities to develop an efficient and selective three-colour ionization scheme for the purely radioactive element astatine. A LabVIEW based monitoring, control and measurement system was conceived which enabled, in conjunction with Dual RILIS operation, the spectroscopy of high lying Rydberg states, from which the ionization potential of the astatine atom was determined for the first time experimentally.

  13. 21 CFR 201.70 - Calcium labeling.

    Science.gov (United States)

    2010-04-01

    ... diet”. The warnings in §§ 201.64(c), 201.70(c), 201.71(c), and 201.72(c) may be combined, if applicable, provided the ingredients are listed in alphabetical order, e.g., a calcium or sodium restricted diet. 1...

  14. 43 CFR 20.201 - Ethics officials.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Ethics officials. 20.201 Section 20.201... Department Ethics Program § 20.201 Ethics officials. (a) Designated Agency Ethics Official refers to the official designated under 5 CFR 2638.201 to coordinate and manage the Department's ethics program. (b)...

  15. Radiobiological Effects of Alpha-Particles from Astatine-211: From DNA Damage to Cell Death

    Energy Technology Data Exchange (ETDEWEB)

    Claesson, Kristina

    2011-05-15

    In recent years, the use of high linear energy transfer (LET) radiation for radiotherapeutic applications has gained increased interest. Astatine-211 (211At) is an alpha-particle emitting radionuclide, promising for targeted radioimmunotherapy of isolated tumor cells and microscopic clusters. To improve development of safe radiotherapy using 211At it is important to increase our knowledge of the radiobiological effects in cells. During radiotherapy, both tumors and adjacent normal tissue will be irradiated and therefore, it is of importance to understand differences in the radio response between proliferating and resting cells. The aim of this thesis was to investigate effects in fibroblasts with different proliferation status after irradiation with alpha-particles from 211At or X-rays, from inflicted DNA damage, to cellular responses and biological consequences. Throughout this work, irradiation was performed with alpha-particles from 211A or X-rays. The induction and repair of double-strand breaks (DSBs) in human normal fibroblasts were investigated using pulsed-field gel electrophoresis and fragment analysis. The relative biological effectiveness (RBE) of 211At for DSB induction varied between 1.4 and 3.1. A small increase of DSBs was observed in cycling cells compared to stationary cells. The repair kinetics was slower after 211At and more residual damage was found after 24 h. Comparison between cells with different proliferation status showed that the repair was inefficient in cycling cells with more residual damage, regardless of radiation quality. Activation of cell cycle arrests was investigated using immunofluorescent labeling of the checkpoint kinase Chk2 and by measuring cell cycle distributions with flow cytometry analysis. After alpha-particle irradiation, the average number of Chk2-foci was larger and the cells had a more affected cell cycle progression for several weeks compared with X-irradiated cells, indicating a more powerful arrest after 211At

  16. Main: PPD201 [AT Atlas

    Lifescience Database Archive (English)

    Full Text Available roaki Kato Graduate School of Pharmaceutical Sciences, Kyoto University Nat Protoc (2006)|Protein Expr. Purif. (2009)|Biotechnol. Prog. (1996) 17406338|8845106|18984054 PPD201.csml ...

  17. 47 CFR 20.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Purpose. 20.1 Section 20.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES COMMERCIAL MOBILE RADIO SERVICES... to commercial mobile radio service providers....

  18. 21 CFR 201.71 - Magnesium labeling.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Magnesium labeling. 201.71 Section 201.71 Food and... LABELING Labeling Requirements for Over-the-Counter Drugs § 201.71 Magnesium labeling. (a) The labeling of over-the-counter (OTC) drug products intended for oral ingestion shall contain the magnesium...

  19. 50 CFR 300.201 - Definition.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Definition. 300.201 Section 300.201 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Definition of Illegal, Unreported, or Unregulated Fishing § 300.201 Definition. Illegal, unreported,...

  20. 40 CFR 88.201-94 - Scope.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Scope. 88.201-94 Section 88.201-94 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CLEAN-FUEL VEHICLES California Pilot Test Program § 88.201-94 Scope. Applicability. The requirements of this...

  1. 49 CFR 377.201 - Scope.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Scope. 377.201 Section 377.201 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION... Forwarders § 377.201 Scope. (a) General. These regulations apply to the extension of credit in...

  2. 40 CFR 201.22 - Measurement instrumentation.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Measurement instrumentation. 201.22 Section 201.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT... Criteria § 201.22 Measurement instrumentation. (a) A sound level meter or alternate sound level...

  3. 17 CFR 201.104 - Business hours.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Business hours. 201.104 Section 201.104 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Rules of Practice General Rules § 201.104 Business hours. The Headquarters office of the Commission,...

  4. 31 CFR 800.201 - Business day.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Business day. 800.201 Section 800.201 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF INVESTMENT... FOREIGN PERSONS Definitions § 800.201 Business day. The term business day means Monday through...

  5. 12 CFR 563.201 - Corporate opportunity.

    Science.gov (United States)

    2010-01-01

    ...-OPERATIONS Reporting and Bonding § 563.201 Corporate opportunity. (a) If you are a director or officer of a... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Corporate opportunity. 563.201 Section 563.201... duty to a savings association, you must not take advantage of corporate opportunities belonging to...

  6. 48 CFR 201.403 - Individual deviations.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Individual deviations. 201.403 Section 201.403 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... Individual deviations. (1) Individual deviations, except those described in 201.402(1) and paragraph (2)...

  7. 19 CFR 201.204 - Salary offset.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Salary offset. 201.204 Section 201.204 Customs... § 201.204 Salary offset. (a) Notice requirements before offset where the Commission is the creditor... the employee with a written Notice of Intent to Offset a minimum of 30 calendar days before...

  8. 19 CFR 201.206 - Administrative offset.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Administrative offset. 201.206 Section 201.206... Collection § 201.206 Administrative offset. (a) Collection. The Director may collect a claim pursuant to 31 U... Government by administrative offset of monies payable by the Government. Collection by administrative...

  9. 49 CFR 393.201 - Frames.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Frames. 393.201 Section 393.201 Transportation... SAFE OPERATION Frames, Cab and Body Components, Wheels, Steering, and Suspension Systems § 393.201 Frames. (a) The frame or chassis of each commercial motor vehicle shall not be cracked, loose, sagging...

  10. 33 CFR 136.201 - Authorized claimants.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Authorized claimants. 136.201 Section 136.201 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED... PROCEDURES; DESIGNATION OF SOURCE; AND ADVERTISEMENT Procedures for Particular Claims § 136.201...

  11. 7 CFR 22.201 - Coordination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Coordination. 22.201 Section 22.201 Agriculture Office of the Secretary of Agriculture RURAL DEVELOPMENT COORDINATION Roles and Responsibilities of Federal Government § 22.201 Coordination. The following identifies types and levels of coordination: (a)...

  12. 17 CFR 201.58 - Judicial review.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Judicial review. 201.58 Section 201.58 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Regulations Pertaining to the Equal Access to Justice Act § 201.58 Judicial review. Judicial review of...

  13. 7 CFR 201.21 - Hard seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Hard seed. 201.21 Section 201.21 Agriculture..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling Agricultural Seeds § 201.21 Hard seed. The label shall show the percentage of hard...

  14. 7 CFR 201.30 - Hard seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Hard seed. 201.30 Section 201.30 Agriculture..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling Vegetable Seeds § 201.30 Hard seed. The label shall show the percentage of hard seed,...

  15. 7 CFR 201.15 - Weed seeds.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Weed seeds. 201.15 Section 201.15 Agriculture... REGULATIONS Labeling Agricultural Seeds § 201.15 Weed seeds. The percentage of weed seeds shall include seeds of plants considered weeds in the State into which the seed is offered for transportation...

  16. 7 CFR 201.50 - Weed seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Weed seed. 201.50 Section 201.50 Agriculture... REGULATIONS Purity Analysis in the Administration of the Act § 201.50 Weed seed. Seeds (including bulblets or tubers) of plants shall be considered weed seeds when recognized as weed seeds by the law or rules...

  17. 31 CFR 551.201 - Prohibited transactions.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Prohibited transactions. 551.201 Section 551.201 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE... § 551.201: Section 203 of the International Emergency Economic Powers Act (50 U.S.C. 1701-1706)...

  18. 5 CFR 295.201 - General prohibition.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false General prohibition. 295.201 Section 295.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS TESTIMONY BY OPM... for Testimony and Production of Documents § 295.201 General prohibition. No employee may...

  19. 44 CFR 201.2 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 201.2 Section 201.2 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE MITIGATION PLANNING § 201.2 Definitions. Administrator means the head of...

  20. 34 CFR 682.201 - Eligible borrowers.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Eligible borrowers. 682.201 Section 682.201 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION FEDERAL FAMILY EDUCATION LOAN (FFEL) PROGRAM General Provisions § 682.201...

  1. 28 CFR 31.201 - Audit.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Audit. 31.201 Section 31.201 Judicial Administration DEPARTMENT OF JUSTICE OJJDP GRANT PROGRAMS Formula Grants General Requirements § 31.201 Audit. The State must assure that it adheres to the audit requirements enumerated in the “Financial...

  2. 44 CFR 201.1 - Purpose.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Purpose. 201.1 Section 201.1 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE MITIGATION PLANNING § 201.1 Purpose. (a) The purpose of this part is to...

  3. 7 CFR 1206.201 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... INFORMATION Rules and Regulations § 1206.201 Definitions. Organic Act means section 2103 of the Organic Foods... 7 Agriculture 10 2010-01-01 2010-01-01 false Definitions. 1206.201 Section 1206.201 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING...

  4. 4 CFR 201.13 - Business information.

    Science.gov (United States)

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Business information. 201.13 Section 201.13 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PUBLIC INFORMATION AND REQUESTS § 201.13 Business information. (a) In general. Business information obtained by the Board from a submitter shall be...

  5. 21 CFR 201.105 - Veterinary drugs.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Veterinary drugs. 201.105 Section 201.105 Food and... LABELING Exemptions From Adequate Directions for Use § 201.105 Veterinary drugs. A drug subject to the... under State law to dispense veterinary prescription drugs, who is regularly and lawfully engaged...

  6. 7 CFR 718.201 - Farm constitution.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Farm constitution. 718.201 Section 718.201 Agriculture... Reconstitution of Farms, Allotments, Quotas, and Bases § 718.201 Farm constitution. (a) In order to implement... this section. The constitution and identification of land as a farm for the first time and...

  7. 48 CFR 1519.201 - Policy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 1519.201 Section 1519.201 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 1519.201 Policy. Each program's Assistant or Associate...

  8. 48 CFR 1834.201 - Policy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 1834.201 Section 1834.201 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION Earned Value Management System 1834.201 Policy....

  9. 18 CFR 2.201 - [Reserved

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false 2.201 Section 2.201 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY GENERAL RULES GENERAL POLICY AND INTERPRETATIONS Rules of General Applicability § 2.201 Statement of...

  10. Dicty_cDB: SLC201 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SL (Link to library) SLC201 (Link to dictyBase) - - - Contig-U16325-1 SLC201E (Link... to Original site) - - - - - - SLC201E 510 Show SLC201 Library SL (Link to library) Clone ID SLC201 (Link to...ycdb.biol.tsukuba.ac.jp/CSM/SL/SLC2-A/SLC201Q.Seq.d/ Representative seq. ID SLC20...1E (Link to Original site) Representative DNA sequence >SLC201 (SLC201Q) /CSM/SL/SLC2-A/SLC201Q.Seq.d/ AACCA...hqqvdgvmisqi*vtikqvlklqlmlm kpkgvkdhiiifhqtiyikktmiiwvmvfmmvlklvsltevst*tismvf Frame B: tns*tktttpwlssr*lr*r*emylc

  11. Dicty_cDB: CHR201 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available CH (Link to library) CHR201 (Link to dictyBase) - - - Contig-U16427-1 CHR201P (Link to Original site) CHR...201F 614 CHR201Z 157 CHR201P 751 - - Show CHR201 Library CH (Link to library) Clone ID CHR... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/CH/CHR2-A/CHR201Q.Seq.d/ Representative seq. ID CHR...201P (Link to Original site) Representative DNA sequence >CHR201 (CHR201Q) /CSM/CH/CHR2-A/CHR2...xr*i*ric*kx Frame B: fncvivlcvyfg*ytlyiyiiq*nviffrtdfrkdgfhr*ry*ihgns*sck*irkryf*

  12. 7 CFR 201.11a - Hybrid.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Hybrid. 201.11a Section 201.11a Agriculture... REGULATIONS Labeling Agricultural Seeds § 201.11a Hybrid. If any one kind or kind and variety of seed present in excess of 5 percent is “hybrid” seed, it shall be designated “hybrid” on the label. The...

  13. Final Report for research grant "Development of Methods for High Specific Activity Labeling of Biomolecules Using Astatine-211 in Different Oxidation States"

    Energy Technology Data Exchange (ETDEWEB)

    Wilbur, D., Scott

    2011-12-14

    The overall objective of this research effort was to develop methods for labeling biomolecules with higher oxidation state species of At-211. This was to be done in an effort to develop reagents that had higher in vivo stability than the present carbon-bonded At-211-labeled compounds. We were unsuccessful in that effort, as none of the approaches studied provided reagents that were stable to in vivo deastatination. However, we gained a lot of information about At-211 in higher oxidation states. The studies proved to be very difficult as small changes in pH and other conditions appeared to change the nature of the species that obtained (by HPLC retention time analyses), with many of the species being unidentifiable. The fact that there are no stable isotopes of astatine, and the chemistry of the nearest halogen iodine is quite different, made it very difficult to interpret results of some experiments. With that said, we believe that a lot of valuable information was obtained from the studies. The research effort evaluated: (1) methods for chemical oxidation of At-211, (2) approaches to chelation of oxidized At-211, and (3) approaches to oxidation of astatophenyl compounds. A major hurdle that had to be surmounted to conduct the research was the development of HPLC conditions to separate and identify the various oxidized species formed. Attempts to develop conditions for separation of iodine and astatine species by normal and reversed-phase TLC and ITLC were not successful. However, we were successful in developing conditions (from a large number of attempts) to separate oxidized forms of iodine ([I-125]iodide, [I-125]iodate and [I-125]periodate) and astatine ([At-211]astatide, [At-211]astatate, [At-211]perastatate, and several unidentified At-211 species). Information on the basic oxidation and characterization of At-211 species is provided under Objective 1. Conditions were developed to obtain new At-211 labeling method where At-211 is chelated with the DOTA and

  14. Dicty_cDB: SHF201 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SH (Link to library) SHF201 (Link to dictyBase) - - - Contig-U16508-1 - (Link to Original site) - - SHF...201Z 629 - - - - Show SHF201 Library SH (Link to library) Clone ID SHF201 (Link to dicty...iol.tsukuba.ac.jp/CSM/SH/SHF2-A/SHF201Q.Seq.d/ Representative seq. ID - (Link to ...Original site) Representative DNA sequence >SHF201 (SHF201Q) /CSM/SH/SHF2-A/SHF201Q.Seq.d/ XXXXXXXXXXCAACCAG...er*wswc wstne*vnsnryn**idfp*yfklcsislsscctlfitsitpnvynhstifkrlefsisr clltidfsltftkwfkdsnstmvr*sr*yhtfty*kylsn*wsrftrstnyhf

  15. 44 CFR 201.3 - Responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Responsibilities. 201.3... HOMELAND SECURITY DISASTER ASSISTANCE MITIGATION PLANNING § 201.3 Responsibilities. (a) General. This section identifies the key responsibilities of FEMA, States, and local/tribal governments in carrying...

  16. 27 CFR 40.201 - Inventories.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Inventories. 40.201... PROCESSED TOBACCO Operations by Manufacturers of Tobacco Products Inventories and Reports § 40.201 Inventories. Every manufacturer of tobacco products shall make true and accurate inventories on Form...

  17. 48 CFR 201.170 - Peer Reviews.

    Science.gov (United States)

    2010-10-01

    ... Procurement and Acquisition Policy, will organize teams of reviewers and facilitate Peer Reviews for... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Peer Reviews. 201.170... OF DEFENSE GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 201.170...

  18. 42 CFR 93.201 - Allegation.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Allegation. 93.201 Section 93.201 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  19. 48 CFR 302.201 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... Section 302.201 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES GENERAL DEFINITIONS OF WORDS AND TERMS Definitions Clause 302.201 Contract clause. The Contracting Officer shall insert the clause in FAR 52.202-1, Definitions, in solicitations and contracts, except as cited below. This is...

  20. 17 CFR 201.57 - Commission review.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Commission review. 201.57... Regulations Pertaining to the Equal Access to Justice Act § 201.57 Commission review. In accordance with the... Division of the Commission may seek review of the initial decision on the fee application, or...

  1. 21 CFR 155.201 - Canned mushrooms.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Canned mushrooms. 155.201 Section 155.201 Food and... mushrooms. (a) Identity—(1) Definition. Canned mushrooms is the food properly prepared from the caps and stems of succulent mushrooms conforming to the characteristics of the species Agaricus...

  2. 5 CFR 412.201 - Management succession.

    Science.gov (United States)

    2010-01-01

    ..., MANAGEMENT, AND EXECUTIVE DEVELOPMENT Succession Planning § 412.201 Management succession. The head of each agency, in consultation with OPM, must develop a comprehensive management succession program, based on... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Management succession. 412.201...

  3. 7 CFR 1430.201 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1430.201 Section 1430.201 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. (a) This program is administered under the general supervision of the Executive Vice...

  4. Dicty_cDB: VFG201 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available VF (Link to library) VFG201 (Link to dictyBase) - - - Contig-U16455-1 VFG201P (Link to Original site) VFG20...1F 186 VFG201Z 594 VFG201P 780 - - Show VFG201 Library VF (Link to library) Clone ID VFG20... URL http://dictycdb.biol.tsukuba.ac.jp/CSM/VF/VFG2-A/VFG201Q.Seq.d/ Representative seq. ID VFG20...1P (Link to Original site) Representative DNA sequence >VFG201 (VFG201Q) /CSM/VF/VFG2-A/VFG20...KAPGKAG DKKGAAAPSKKK*ii*kkfy Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits) Value VFG201 (VFG20

  5. 41 CFR 50-201.1101 - Minimum wages.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Minimum wages. 50-201.1101 Section 50-201.1101 Public Contracts and Property Management Other Provisions Relating to Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 201-GENERAL REGULATIONS § 50-201.1101 Minimum wages. Determinations of prevailing minimum wages...

  6. 48 CFR 1631.201-70 - Credits.

    Science.gov (United States)

    2010-10-01

    ... AND PROCEDURES Contracts With Commercial Organizations 1631.201-70 Credits. The provisions of FAR 31... checks; (d) Utilization review refunds; (e) Contract prescription drug rebates; (f) Volume discounts;...

  7. 23 CFR 230.201 - Purpose.

    Science.gov (United States)

    2010-04-01

    ... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CIVIL RIGHTS EXTERNAL PROGRAMS Supportive Services for Minority, Disadvantaged, and Women Business Enterprises § 230.201 Purpose. To prescribe the... programs for minority, disadvantaged, and women business enterprises....

  8. 7 CFR 1219.201 - Definitions.

    Science.gov (United States)

    2010-01-01

    ..., AND INFORMATION Rules and Regulations § 1219.201 Definitions. Organic Act means section 2103 of the Organic Foods Production Act of 1990 (7 U.S.C. 6502). ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING...

  9. Thallium-201 uptake in Langerhans` cell histiocytosis of bone

    Energy Technology Data Exchange (ETDEWEB)

    Bar-Sever, Z. [Division of Nuclear Medicine, Department of Radiology, Children`s Hospital and Harvard Medical School, Boston, MA (United States); Connolly, L.P. [Division of Nuclear Medicine, Department of Radiology, Children`s Hospital and Harvard Medical School, Boston, MA (United States); Jaramillo, D. [Division of Nuclear Medicine, Department of Radiology, Children`s Hospital and Harvard Medical School, Boston, MA (United States); Treves, S.T. [Division of Nuclear Medicine, Department of Radiology, Children`s Hospital and Harvard Medical School, Boston, MA (United States)

    1996-10-01

    A case in which there was thallium-201 ({sup 201}Tl) uptake in Langerhans` cell histiocytosis (LCH) of the left femoral diaphysis is presented. The authors propose that {sup 201}Tl scintigraphy is potentially useful in the diagnosis and follow-up of patients with LCH. (orig.). With 4 figs.

  10. 19 CFR 201.110 - Self-evaluation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Self-evaluation. 201.110 Section 201.110 Customs... Commission § 201.110 Self-evaluation. (a) The agency shall, by April 9, 1987, evaluate its current policies... in the self-evaluation process by submitting comments (both oral and written). (c) The agency...

  11. 46 CFR 201.117 - Inclusion in record.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Inclusion in record. 201.117 Section 201.117 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Discovery and Depositions (Rule 11) § 201.117 Inclusion in record. No deposition or part...

  12. 21 CFR 201.61 - Statement of identity.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Statement of identity. 201.61 Section 201.61 Food...: GENERAL LABELING Labeling Requirements for Over-the-Counter Drugs § 201.61 Statement of identity. (a) The... features a statement of the identity of the commodity. (b) Such statement of identity shall be in terms...

  13. 17 CFR 201.1100 - Creation of Fair Fund.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Creation of Fair Fund. 201.1100 Section 201.1100 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Fair Fund and Disgorgement Plans § 201.1100 Creation of Fair Fund. In any agency process initiated by an order instituting proceedings in...

  14. 10 CFR 63.201 - Purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Purpose and scope. 63.201 Section 63.201 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) DISPOSAL OF HIGH-LEVEL RADIOACTIVE WASTES IN A GEOLOGIC REPOSITORY AT YUCCA MOUNTAIN, NEVADA Preclosure Public Health and Environmental Standards § 63.201 Purpose and scope....

  15. 7 CFR 868.201 - Definition of rough rice.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Definition of rough rice. 868.201 Section 868.201... FOR CERTAIN AGRICULTURAL COMMODITIES United States Standards for Rough Rice Terms Defined § 868.201 Definition of rough rice. Rice (Oryza sativa L.) which consists of 50 percent or more of paddy kernels...

  16. 46 CFR 201.131 - Presentation of evidence.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Presentation of evidence. 201.131 Section 201.131... PRACTICE AND PROCEDURE Hearing Procedures (Rule 13) § 201.131 Presentation of evidence. (a) Testimony... specifically encouraged to cooperate with each other in joint presentations particularly in such items as...

  17. 14 CFR 1203.201 - Information security objectives.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Information security objectives. 1203.201 Section 1203.201 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM NASA Information Security Program § 1203.201 Information security objectives. The objectives of the NASA Information Security Program...

  18. 7 CFR 201.56-5 - Grass family, Poaceae (Gramineae).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Grass family, Poaceae (Gramineae). 201.56-5 Section... ACT FEDERAL SEED ACT REGULATIONS Germination Tests in the Administration of the Act § 201.56-5 Grass... grasses listed in § 201.2(h). (a) Cereals: Agrotricum, barley, oat, rye, mountain rye, wheat,...

  19. 49 CFR 37.201 - Intermediate and rest stops.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Intermediate and rest stops. 37.201 Section 37.201... DISABILITIES (ADA) Over-the-Road Buses (OTRBs) § 37.201 Intermediate and rest stops. (a) Whenever an OTRB makes an intermediate or rest stop, a passenger with a disability, including an individual using...

  20. 9 CFR 201.1 - Meaning of words.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Meaning of words. 201.1 Section 201.1 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND... § 201.1 Meaning of words. Words used in this part in the singular form shall be deemed to import...

  1. 7 CFR 201.1 - Meaning of words.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Meaning of words. 201.1 Section 201.1 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... REGULATIONS Definitions § 201.1 Meaning of words. Words in the regulations in this part in the singular...

  2. 48 CFR 3036.201 - Evaluation of contractor performance.

    Science.gov (United States)

    2010-10-01

    ...) 48 CFR 36.201. Access to reports is through the CPS or the government-wide system, Past Performance... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Evaluation of contractor performance. 3036.201 Section 3036.201 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND...

  3. 48 CFR 2936.201 - Evaluation of contractor performance.

    Science.gov (United States)

    2010-10-01

    ... Construction 2936.201 Evaluation of contractor performance. The HCA must establish procedures to evaluate... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Evaluation of contractor performance. 2936.201 Section 2936.201 Federal Acquisition Regulations System DEPARTMENT OF LABOR...

  4. 7 CFR 201.69 - Classes of certified seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Classes of certified seed. 201.69 Section 201.69..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.69 Classes of certified seed. (a) Classes of certified seed are as...

  5. 7 CFR 201.24a - Inoculated seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Inoculated seed. 201.24a Section 201.24a Agriculture..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling Agricultural Seeds § 201.24a Inoculated seed. Seed claimed to be inoculated shall...

  6. 7 CFR 201.49 - Other crop seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Other crop seed. 201.49 Section 201.49 Agriculture..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Purity Analysis in the Administration of the Act § 201.49 Other crop seed. (a) Seeds of...

  7. 7 CFR 201.64 - Pure live seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Pure live seed. 201.64 Section 201.64 Agriculture..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Tolerances § 201.64 Pure live seed. The tolerance for pure live seed shall be determined...

  8. 7 CFR 201.7a - Treated seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Treated seed. 201.7a Section 201.7a Agriculture..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Records for Agricultural and Vegetable Seeds § 201.7a Treated seed. The complete record for...

  9. 7 CFR 201.31a - Labeling treated seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Labeling treated seed. 201.31a Section 201.31a..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling in General § 201.31a Labeling treated seed. (a) Contents of label. Any agricultural...

  10. 7 CFR 201.47a - Seed unit.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Seed unit. 201.47a Section 201.47a Agriculture..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Purity Analysis in the Administration of the Act § 201.47a Seed unit. The seed unit is...

  11. 7 CFR 201.52 - Noxious-weed seeds.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Noxious-weed seeds. 201.52 Section 201.52 Agriculture... REGULATIONS Purity Analysis in the Administration of the Act § 201.52 Noxious-weed seeds. (a) The determination of the number of seeds, bulblets, or tubers of individual noxious weeds present per unit...

  12. 46 CFR 201.8 - Use of gender and number.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Use of gender and number. 201.8 Section 201.8 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE General Information (Rule 1) § 201.8 Use of gender and number. Words importing the singular...

  13. 19 CFR 201.40 - Records-retention requirements.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Records-retention requirements. 201.40 Section 201.40 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Opening Commission Meetings to Public Observation Pursuant to 5 U.S.C. 552b § 201.40...

  14. Thallium-201 accumulation in cerebral candidiasis: Unexpected finding on SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Tonami, N.; Matsuda, H.; Ooba, H.; Yokoyama, K.; Hisada, K.; Ikeda, K.; Yamashita, J. (Kanazawa Univ. (Japan))

    1990-06-01

    The authors present an unexpected finding of Tl-201 uptake in the intracerebral lesions due to candidiasis. SPECT demonstrated the extent of the lesions and a high target-to-background ratio. The regions where abnormal Tl-201 accumulation was seen were nearly consistent with CT scans of those enhanced by a contrast agent. After treatment, most of the abnormal Tl-201 accumulation disappeared.

  15. 7 CFR 201.58d - Fungal endophyte test.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Fungal endophyte test. 201.58d Section 201.58d... REGULATIONS Examinations in the Administration of the Act § 201.58d Fungal endophyte test. A fungal endophyte test may be used to determine the amount of fungal endophyte (Acremonium spp.) in certain grasses....

  16. 44 CFR 201.5 - Enhanced State Mitigation Plans.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Enhanced State Mitigation Plans. 201.5 Section 201.5 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE MITIGATION PLANNING § 201.5 Enhanced State...

  17. 44 CFR 201.4 - Standard State Mitigation Plans.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Standard State Mitigation Plans. 201.4 Section 201.4 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY DISASTER ASSISTANCE MITIGATION PLANNING § 201.4 Standard State...

  18. 22 CFR 201.41 - Audit and inspection.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Audit and inspection. 201.41 Section 201.41...-Related Services § 201.41 Audit and inspection. The borrower/grantee shall maintain records adequate to... to identify the importer (or the first purchaser or transferee if the commodity is imported by...

  19. 48 CFR 1327.201 - Patent and copyright infringement liability.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Patent and copyright infringement liability. 1327.201 Section 1327.201 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patents and Copyrights 1327.201 Patent...

  20. 19 CFR 201.4 - Performance of functions.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Performance of functions. 201.4 Section 201.4 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION GENERAL RULES OF GENERAL APPLICATION Miscellaneous § 201.4 Performance of functions. (a) Conduct of business. A majority of the members of...

  1. 49 CFR 179.201-3 - Lined tanks.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Lined tanks. 179.201-3 Section 179.201-3... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-3 Lined tanks. (a)...

  2. 7 CFR 201.78 - Pollen control for hybrids.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Pollen control for hybrids. 201.78 Section 201.78... REGULATIONS Additional Requirements for the Certification of Plant Materials of Certain Crops § 201.78 Pollen... branches, or any combination thereof, shedding pollen. (c) Sorghum. Shedders in the seed parent, at any...

  3. 46 CFR 201.22 - Firms and corporations.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Firms and corporations. 201.22 Section 201.22 Shipping... PROCEDURE Appearance and Practice Before the Administration (Rule 2) § 201.22 Firms and corporations. Except as regards law firms, practice before the Administration by firms or corporations on behalf of...

  4. 14 CFR 1206.201 - Records which have been published.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Records which have been published. 1206.201 Section 1206.201 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Records Available § 1206.201 Records which have been...

  5. 21 CFR 201.116 - Drugs having commonly known directions.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Drugs having commonly known directions. 201.116 Section 201.116 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Exemptions From Adequate Directions for Use § 201.116 Drugs...

  6. 7 CFR 201.54 - Number of seeds for germination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Number of seeds for germination. 201.54 Section 201.54... REGULATIONS Germination Tests in the Administration of the Act § 201.54 Number of seeds for germination. At least 400 seeds shall be tested for germination; except that in mixtures, 200 seeds of each of...

  7. 17 CFR 242.201 - Price test.

    Science.gov (United States)

    2010-04-01

    ... M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation Sho... convenience of the user, the revised text is set forth as follows: § 242.201 Circuit breaker. (a) Definitions... security is by a market maker to offset customer odd-lot orders or to liquidate an odd-lot position...

  8. 37 CFR 41.201 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Definitions. 41.201 Section... Definitions. In addition to the definitions in §§ 41.2 and 41.100, the following definitions apply to... invention. Involved claim means, for the purposes of 35 U.S.C. 135(a), a claim that has been designated...

  9. 42 CFR 56.201 - Applicability.

    Science.gov (United States)

    2010-10-01

    ... PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS GRANTS FOR MIGRANT HEALTH SERVICES Grants for Planning and Developing Migrant Health Centers § 56.201 Applicability. The regulations of this... pursuant to section 319(c)(1)(A) of the Act for projects for planning and developing migrant health...

  10. 48 CFR 419.201 - General policy.

    Science.gov (United States)

    2010-10-01

    ... SMALL BUSINESS PROGRAMS Policies 419.201 General policy. It is the policy of USDA to provide maximum practicable contracting and subcontracting opportunities to small business (SB), small disadvantaged business (SDB), HUBZone small business, women-owned business (WOB), veteran-owned small business (VOSB),......

  11. 48 CFR 919.201 - General policy.

    Science.gov (United States)

    2010-10-01

    ... disadvantaged, and women-owned small business programs. The Executive Director, Federal Energy Regulatory... agencies on matters primarily affecting small, small disadvantaged, and women-owned small businesses. The... BUSINESS PROGRAMS Policies 919.201 General policy. (c) The Director, Office of Small and...

  12. 48 CFR 3019.201 - General policy.

    Science.gov (United States)

    2010-10-01

    ... owned small businesses, HUBZone small businesses, small disadvantaged businesses, and women-owned small... ACQUISITION REGULATION (HSAR) SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Policies 3019.201 General policy. (d) DHS is committed to a unified team approach involving senior management, small...

  13. 40 CFR 61.201 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Phosphogypsum Stacks § 61.201 Definitions. As used in this subpart, all terms not defined here have the meaning... specific meanings: (a) Inactive stack means a stack to which no further routine additions of phosphogypsum... phosphogypsum. If a stack has not been used for either purpose for two years, it is presumed to be inactive....

  14. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211

    Energy Technology Data Exchange (ETDEWEB)

    O’Hara, Matthew J.; Krzysko, Anthony J.; Niver, Cynthia M.; Morrison, Samuel S.; Owsley, Stanley L.; Hamlin, Donald K.; Dorman, Eric F.; Scott Wilbur, D.

    2017-04-01

    Astatine-211 (211At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy of blood borne and metastatic cancers, as well as treatment of tumor remnants after surgical resections. The isolation of trace quantities of 211At, produced within several grams of a Bi metal cyclotron target, involves a complex, multi-step procedure: (1) Bi metal dissolution in strong HNO3, (2) distillation of the HNO3 to yield Bi salts containing 211At, (3) dissolution of the salts in strong HCl, (4) solvent extraction of 211At from bismuth salts with diisopropyl ether (DIPE), and (5) back-extraction of 211At from DIPE into NaOH, leading to a purified 211At product. Step (1) has been addressed first to begin the process of automating the onerous 211At isolation process. A computer-controlled Bi target dissolution system has been designed. The system performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized 211At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (HNO3 concentration and influent flow rate) were optimized prior to evaluation of the system performance on replicate cyclotron irradiated targets. The results indicate that the system performs reproducibly, having nearly quantitative release of 211At from irradiated targets, with cumulative 211At recoveries that follow a sigmoidal function. The predictable nature of the 211At release profile allows the user to tune the system to meet target processing requirements.

  15. 22 CFR 201.68 - Maximum prices for commodity-related services.

    Science.gov (United States)

    2010-04-01

    .... 201.68 Section 201.68 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES AND PROCEDURES APPLICABLE TO COMMODITY TRANSACTIONS FINANCED BY USAID Price Provisions § 201.68 Maximum prices for commodity... each such service is eligible for USAID-financing under § 201.67 or § 201.68(a) of this part....

  16. 7 CFR 201.26 - Kind, variety, and hybrid.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Kind, variety, and hybrid. 201.26 Section 201.26... REGULATIONS Labeling Vegetable Seeds § 201.26 Kind, variety, and hybrid. The label shall bear the name of each... kind or variety named on the label is “hybrid” seed, it shall be so designated on the label. If two...

  17. 21 CFR 201.63 - Pregnancy/breast-feeding warning.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Pregnancy/breast-feeding warning. 201.63 Section...) DRUGS: GENERAL LABELING Labeling Requirements for Over-the-Counter Drugs § 201.63 Pregnancy/breast... during pregnancy or while nursing has been established for a particular drug product in a new...

  18. 5 CFR 250.201 - Coverage and purpose.

    Science.gov (United States)

    2010-01-01

    ....201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Strategic Human Capital Management § 250.201 Coverage and purpose. The Chief Human... the strategic management of the Federal civil service, and pursuant to 5 U.S.C. 1103, OPM...

  19. 21 CFR 201.50 - Statement of identity.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Statement of identity. 201.50 Section 201.50 Food... identity. (a) The label of prescription and insulin-containing drugs in package form shall bear as one of its principal features a statement of the identity of the drug. (b) Such statement of identity...

  20. 46 CFR 201.76 - Applications for Government aid.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Applications for Government aid. 201.76 Section 201.76... Government aid. Applications for operating-differential subsidies, charter of Government-owned vessels, and other types of Government aid shall conform to the requirements set forth in the various general...

  1. 14 CFR 1207.201 - Scope of subpart.

    Science.gov (United States)

    2010-01-01

    ... who are subject to the restrictions of Title V of the Ethics of Government Act of 1978, as amended... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Scope of subpart. 1207.201 Section 1207.201 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION STANDARDS OF CONDUCT...

  2. 37 CFR 201.25 - Visual Arts Registry.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Visual Arts Registry. 201.25... AND PROCEDURES GENERAL PROVISIONS § 201.25 Visual Arts Registry. (a) General. This section prescribes the procedures relating to the submission of Visual Arts Registry Statements by visual artists...

  3. 41 CFR 101-27.201 - Scope of subpart.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Scope of subpart. 101-27.201 Section 101-27.201 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS SUPPLY AND PROCUREMENT 27-INVENTORY MANAGEMENT...

  4. 22 CFR 201.13 - Eligibility of delivery services.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Eligibility of delivery services. 201.13... for USAID Financing § 201.13 Eligibility of delivery services. (a) General. Delivery of USAID-financed commodities may be financed under the implementing document provided the delivery services meet...

  5. 22 CFR 201.21 - Notice to supplier.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Notice to supplier. 201.21 Section 201.21 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES AND PROCEDURES APPLICABLE TO COMMODITY... supplier. The importer is responsible for providing the supplier with the following information...

  6. 5 CFR 2610.201 - Contents of application.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Contents of application. 2610.201 Section 2610.201 Administrative Personnel OFFICE OF GOVERNMENT ETHICS ORGANIZATION AND PROCEDURES... Agricultural Marketing Act (12 U.S.C. 1141j(a)). (c) The application shall state the amount of fees...

  7. 22 CFR 201.51 - Methods of financing.

    Science.gov (United States)

    2010-04-01

    .... All requests for bank letters of commitment shall be in the English language and shall be submitted to... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Methods of financing. 201.51 Section 201.51 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES AND PROCEDURES APPLICABLE TO...

  8. 41 CFR 50-201.501 - Records of employment.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Records of employment. 50-201.501 Section 50-201.501 Public Contracts and Property Management Other Provisions Relating to... years from their last date of entry; (e) Basic employment and earnings records: All basic time...

  9. 48 CFR 436.201 - Evaluation of contractor performance.

    Science.gov (United States)

    2010-10-01

    ... Construction 436.201 Evaluation of contractor performance. Preparation of performance evaluation reports. In addition to the requirements of FAR 36.201, performance evaluation reports shall be prepared for indefinite... of services to be ordered exceeds $500,000.00. For these contracts, performance evaluation...

  10. 41 CFR 50-201.603 - Full administrative exemptions.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Full administrative exemptions. 50-201.603 Section 50-201.603 Public Contracts and Property Management Other Provisions Relating... defaulting contractor where the stipulations required in this section were not included in the...

  11. 31 CFR 29.201 - Purpose and scope.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Purpose and scope. 29.201 Section 29.201 Money and Finance: Treasury Office of the Secretary of the Treasury FEDERAL BENEFIT PAYMENTS UNDER CERTAIN DISTRICT OF COLUMBIA RETIREMENT PROGRAMS Coordination With the District Government §...

  12. 7 CFR 201.77 - Length of stand requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Length of stand requirements. 201.77 Section 201.77... of stand requirements. (a) Alfalfa. Limitations on the age of stand and certified seed classes... class, provided the stand of perennial plants is maintained. (d) Sainfoin. All certified seed...

  13. 41 CFR 50-201.101 - Employees affected.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Employees affected. 50... Public Contracts PUBLIC CONTRACTS, DEPARTMENT OF LABOR 201-GENERAL REGULATIONS § 50-201.101 Employees affected. The stipulations shall be deemed applicable only to employees engaged in or connected with...

  14. 17 CFR 256.201 - Common stock issued.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Common stock issued. 256.201... COMPANY ACT OF 1935 Liabilities and Other Credit Accounts § 256.201 Common stock issued. This account shall include the par or stated value of all common capital stock issued and outstanding....

  15. 5 CFR 294.201 - Public information policy.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Public information policy. 294.201... AVAILABILITY OF OFFICIAL INFORMATION The Public Information Function § 294.201 Public information policy. (a... requested by a member of the public, the Office has an independent public information policy for bringing...

  16. 7 CFR 1463.201 - Refunds of importer assessments.

    Science.gov (United States)

    2010-01-01

    ... provisions of 7 CFR 1464.105 that were in effect prior to March 30, 2005, so long as such request for refunds... 7 Agriculture 10 2010-01-01 2010-01-01 false Refunds of importer assessments. 1463.201 Section... PROGRAM Miscellaneous Provisions § 1463.201 Refunds of importer assessments. Assessments paid on...

  17. 29 CFR 18.201 - Official notice of adjudicative facts.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Official notice of adjudicative facts. 18.201 Section 18.201... of adjudicative facts. (a) Scope of rule. This rule governs only official notice of adjudicative facts. (b) Kinds of facts. An officially noticed fact must be one not subject to reasonable dispute...

  18. 24 CFR 92.201 - Distribution of assistance.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Distribution of assistance. 92.201 Section 92.201 Housing and Urban Development Office of the Secretary, Department of Housing and Urban... and objective measures of rural housing need, such as poverty and substandard housing, as set forth...

  19. 17 CFR 201.152 - Filing of papers: Form.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Filing of papers: Form. 201... PRACTICE Rules of Practice General Rules § 201.152 Filing of papers: Form. (a) Specifications. Papers filed... white paper measuring 81/2×11 inches, except that, to the extent that the reduction of larger...

  20. 17 CFR 201.150 - Service of papers by parties.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Service of papers by parties... PRACTICE Rules of Practice General Rules § 201.150 Service of papers by parties. (a) When required. In every proceeding as defined in § 201.101(a), each paper, including each notice of appearance,...

  1. 7 CFR 201.61 - Fluorescence percentages in ryegrasses.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Fluorescence percentages in ryegrasses. 201.61 Section... ACT FEDERAL SEED ACT REGULATIONS Tolerances § 201.61 Fluorescence percentages in ryegrasses. Tolerances for 400-seed fluorescence tests shall be those set forth in the following table plus one-half...

  2. 42 CFR 403.201 - State regulation of insurance policies.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false State regulation of insurance policies. 403.201 Section 403.201 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies General...

  3. 17 CFR 201.65 - Identity and signature.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Identity and signature. 201.65... of 1934 § 201.65 Identity and signature. Applications pursuant to this subpart may omit the identity, mailing address, and signature of the applicant; provided, that such identity, mailing address...

  4. 14 CFR 201.5 - Advertising and sales by applicants.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Advertising and sales by applicants. 201.5... CODE- Application Procedures § 201.5 Advertising and sales by applicants. (a) An applicant for new or amended certificate or commuter air carrier authority shall not: (1) Advertise, list schedules, or...

  5. 17 CFR 201.401 - Consideration of stays.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Consideration of stays. 201... PRACTICE Rules of Practice Appeal to the Commission and Commission Review § 201.401 Consideration of stays... consideration. Where the action complained of has already taken effect and the motion for stay is filed...

  6. 17 CFR 201.500 - Expedited consideration of proceedings.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Expedited consideration of proceedings. 201.500 Section 201.500 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION... Expedited consideration of proceedings. Consistent with the Commission's or the hearing officer's...

  7. 31 CFR 548.201 - Prohibited transactions involving blocked property.

    Science.gov (United States)

    2010-07-01

    ... official who is responsible for or has engaged in public corruption related to Belarus; (iv) To have... 2 to paragraph (a) of § 548.201: The International Emergency Economic Powers Act (50 U.S.C....

  8. 12 CFR 201.3 - Extensions of credit generally.

    Science.gov (United States)

    2010-01-01

    ... securities, and business, consumer, and other customer notes. (3) If a Federal Reserve Bank concludes that a..., § 201.3 was amended by adding paragraph (e), effective Jan. 8, 2010. For the convenience of the...

  9. 38 CFR 1.201 - Employee's duty to report.

    Science.gov (United States)

    2010-07-01

    ... PROVISIONS Referrals of Information Regarding Criminal Violations § 1.201 Employee's duty to report. All VA employees with knowledge or information about actual or possible violations of criminal law related to...

  10. 48 CFR 1427.201 - Patent and copyright infringement liability.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Patent and copyright... INTERIOR GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patents and Copyrights 1427.201 Patent and copyright infringement liability....

  11. 48 CFR 27.201 - Patent and copyright infringement liability.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Patent and copyright... REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patents and Copyrights 27.201 Patent and copyright infringement liability....

  12. 29 CFR 553.201 - Statutory provisions: section 7(k).

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Statutory provisions: section 7(k). 553.201 Section 553.201...: section 7(k). (a) Section 7(k) of the Act provides a partial overtime pay exemption for fire protection.... (b) As specified in §§ 553.20 through 553.28 of subpart A, workers employed under section 7(k)...

  13. Pre-deploy operations with SPARTAN-201 during STS-64

    Science.gov (United States)

    1994-01-01

    The astronauts onboard the Space Shuttle Discovery used a 70mm camera to capture this view of the pre-deply operations with the Shuttle Pointed Autonomous Research Tool for Astronomy (SPARTAN-201). In the grasp of the robot arm device of the Remote Manipulator System (RMS), Spartan-201 hovers above Discovery's cargo bay prior to its two days of free-flight, some 40 miles away from the parent spacecraft.

  14. Early and delayed thallium-201 scintigraphy in thyroid nodules: the relationship between early thallium-201 uptake and perfusion

    Energy Technology Data Exchange (ETDEWEB)

    Derebek, E. [Dept. of Nuclear Medicine, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Biberoglu, S. [Dept. of Internal Medicine, Div. of Endocrinology, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Kut, O. [Dept. of Nuclear Medicine, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Yesil, S. [Dept. of Internal Medicine, Div. of Endocrinology, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Saydam, S. [Dept. of Surgery, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Yilmaz, M. [Dept. of Nuclear Medicine, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Yenici, O. [Dept. of Nuclear Medicine, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Igci, E. [Dept. of Radiology, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Gokce, O. [Dept. of Surgery, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Canda, S. [Dept. of Pathology, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Bueyuekgebiz, A. [Dept. of Pediatrics, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Dogan, A.S. [Dept. of Nuclear Medicine, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey); Durak, H. [Dept. of Nuclear Medicine, Dokuz Eylul Univ., School of Medicine, Izmir (Turkey)

    1996-05-01

    Seventy-six patients with tyroid nodules were studied. Initially, 75 MBq of thallium-201 was injected. The thyroid gland was imaged 15 min (early) and 3 h (delayed) after the injection. Thereafter, 185 MBq technetium-99m pertechnetate was injected. Immediately after the injection, a 1-min perfusion image was acquired, followed by an image at 20 min. Increased early and delayed {sup 201}Tl uptake compared with the contralateral thyroid tissue was adopted as the criterion for malignancy. Sensitivity, specificity and negative predictive values were found to be 85%, 64% and 78%, respectively, in operated patients, but these values were 86%, 87% and 95%, respectively, in the whole group, including patients followed with fine-needle aspiration biopsy. With the purpose of investigating the relationship between perfusion and early {sup 201}Tl uptake, bot perfusion and early images were graded comparing nodular activity with contralateral thyroid activity. There was a poor correlation between perfusion and {sup 201}Tl uptake. The correlation was even worse in hyperactive nodules. It is concluded that early and delayed {sup 201}Tl imaging should not be used in the differential diagnosis of cold nodules and that early {sup 201}Tl uptake seems to be more closely related to factors other than perfusion. (orig.)

  15. Tank characterization report for single-shell Tank B-201

    Energy Technology Data Exchange (ETDEWEB)

    Heasler, P.G.; Remund, K.M.; Tingey, J.M.; Baird, D.B.; Ryan, F.M.

    1994-09-01

    The purpose of this report is to characterize the waste in single shell Tank B-201. Characterization includes the determination of the physical, chemical (e.g., concentrations of elements and organic species), and radiological properties of the waste. These determinations are made using analytical results from B-201 core samples as well as historical information about the tank. The main objective is to determine average waste properties: but in some cases, concentrations of analytes as a function of depth were also determined. This report also consolidates the available historical information regarding Tank B-201, arranges the analytical information from the recent core sampling in a useful format, and provides an interpretation of the data within the context of what is known about the tank.

  16. Experiments with a New 201Hg+ Ion Clock

    Science.gov (United States)

    Burt, E. A.; Taghavi-Larigani, S.; Lea, S. N.; Prestage, J. D.; Tjoelker, R. L.

    2009-04-01

    In this paper we describe a new clock based on 201Hg+. All previous mercury ion clocks have been based on 199Hg+. We have recently completed construction of the 201Hg+ clock and will describe modifications to the design of our existing 199Hg+ clocks to accommodate the new isotope. We will also describe initial spectroscopic measurements of the hyperfine manifold, and possible future experiments. One experiment could place a limit on variations in the strong interaction fundamental constant ratio mq/ΛQCD.REFID="9789812838223_0043FN001">

  17. 17 CFR 201.601 - Prompt payment of disgorge-ment, interest and penalties.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Prompt payment of disgorge-ment, interest and penalties. 201.601 Section 201.601 Commodity and Securities Exchanges SECURITIES AND... § 201.601 Prompt payment of disgorge-ment, interest and penalties. (a) Timing of payments....

  18. 10 CFR 490.201 - Alternative fueled vehicle acquisition mandate schedule.

    Science.gov (United States)

    2010-01-01

    .... 490.201 Section 490.201 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ALTERNATIVE FUEL TRANSPORTATION PROGRAM Mandatory State Fleet Program § 490.201 Alternative fueled vehicle acquisition mandate... annually for State government fleets, including agencies thereof but excluding municipal fleets,...

  19. 17 CFR 201.1101 - Submission of plan of distribution; contents of plan.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Submission of plan of distribution; contents of plan. 201.1101 Section 201.1101 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION RULES OF PRACTICE Fair Fund and Disgorgement Plans § 201.1101 Submission of plan of distribution; contents of plan. (a)...

  20. 21 CFR 201.2 - Drugs and devices; National Drug Code numbers.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Drugs and devices; National Drug Code numbers. 201.2 Section 201.2 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING General Labeling Provisions § 201.2 Drugs and devices; National Drug...

  1. 21 CFR 201.115 - New drugs or new animal drugs.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false New drugs or new animal drugs. 201.115 Section 201.115 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Exemptions From Adequate Directions for Use § 201.115 New drugs or new...

  2. 5 CFR 2641.201 - Permanent restriction on any former employee's representations to United States concerning...

    Science.gov (United States)

    2010-01-01

    ... personally and substantially. 2641.201 Section 2641.201 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS POST-EMPLOYMENT CONFLICT OF INTEREST RESTRICTIONS Prohibitions § 2641.201 Permanent... develop the prototype of a specialized robot. After terminating Government service, the former...

  3. 7 CFR 201.65 - Noxious weed seeds in interstate commerce.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Noxious weed seeds in interstate commerce. 201.65 Section 201.65 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... ACT FEDERAL SEED ACT REGULATIONS Tolerances § 201.65 Noxious weed seeds in interstate...

  4. 7 CFR 201.51b - Purity procedures for coated seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Purity procedures for coated seed. 201.51b Section 201... SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Purity Analysis in the Administration of the Act § 201.51b...

  5. 40 CFR 1033.201 - General requirements for obtaining a certificate of conformity.

    Science.gov (United States)

    2010-07-01

    ... certificate of conformity. 1033.201 Section 1033.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY....201 General requirements for obtaining a certificate of conformity. Certification is the process by... certificate of conformity for freshly manufactured locomotives. Anyone meeting the definition...

  6. 21 CFR 250.201 - Preparations for the treatment of pernicious anemia.

    Science.gov (United States)

    2010-04-01

    ... anemia. 250.201 Section 250.201 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND... Drugs and Foods § 250.201 Preparations for the treatment of pernicious anemia. (a) The ninth announcement of the Anti-anemia Preparations Advisory Board of the United States Pharmacopeia is concerned...

  7. 27 CFR 44.201 - Return to manufacturer or customs warehouse proprietor.

    Science.gov (United States)

    2010-04-01

    ... customs warehouse proprietor. 44.201 Section 44.201 Alcohol, Tobacco Products and Firearms ALCOHOL AND... Proprietors Notice of Removal of Shipment § 44.201 Return to manufacturer or customs warehouse proprietor... to the factory, or cigars are removed from such a warehouse for return to a customs warehouse,...

  8. 7 CFR 201.29 - Germination of vegetable seed in containers of 1 pound or less.

    Science.gov (United States)

    2010-01-01

    ... or less. 201.29 Section 201.29 Agriculture Regulations of the Department of Agriculture (Continued... vegetable seed in containers of 1 pound or less. Vegetable seeds in containers of 1 pound or less which have... percentage less than the standard set forth in § 201.31 shall have the words “Below Standard” clearly...

  9. 21 CFR 201.310 - Phenindione; labeling of drug preparations intended for use by man.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Phenindione; labeling of drug preparations intended for use by man. 201.310 Section 201.310 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements for Specific Drug Products § 201.310...

  10. 21 CFR 201.306 - Potassium salt preparations intended for oral ingestion by man.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Potassium salt preparations intended for oral ingestion by man. 201.306 Section 201.306 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Specific Labeling Requirements for Specific Drug Products § 201.306 Potassium...

  11. 37 CFR 201.23 - Transfer of unpublished copyright deposits to the Library of Congress.

    Science.gov (United States)

    2010-07-01

    ... copyright deposits to the Library of Congress. 201.23 Section 201.23 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES GENERAL PROVISIONS § 201.23 Transfer of unpublished copyright deposits to the Library of Congress. (a) General. This section...

  12. 30 CFR 201.100 - Responsibilities of the Associate Director for Minerals Revenue Management.

    Science.gov (United States)

    2010-07-01

    ... Minerals Revenue Management. 201.100 Section 201.100 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT GENERAL Oil and Gas, Onshore § 201.100 Responsibilities of the Associate Director for Minerals Revenue Management. The Associate Director is...

  13. 5 CFR 410.201 - Responsibilities of the head of an agency.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Responsibilities of the head of an agency. 410.201 Section 410.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS TRAINING Planning and Evaluating Training § 410.201 Responsibilities of the head of an...

  14. 37 CFR 201.24 - Warning of copyright for software lending by nonprofit libraries.

    Science.gov (United States)

    2010-07-01

    ... software lending by nonprofit libraries. 201.24 Section 201.24 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES GENERAL PROVISIONS § 201.24 Warning of copyright for software lending by nonprofit libraries. (a) Definition. A Warning of Copyright for...

  15. 37 CFR 201.14 - Warnings of copyright for use by certain libraries and archives.

    Science.gov (United States)

    2010-07-01

    ... by certain libraries and archives. 201.14 Section 201.14 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES GENERAL PROVISIONS § 201.14 Warnings of copyright for use by certain libraries and archives. (a) Definitions. (1) A Display Warning...

  16. 7 CFR 201.71 - Establishing the source of all classes of certified seed.

    Science.gov (United States)

    2010-01-01

    ... seed. 201.71 Section 201.71 Agriculture Regulations of the Department of Agriculture (Continued... (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.71 Establishing the source of all classes of certified seed. The certifying agency shall have evidence of the class and source...

  17. 7 CFR 201.12a - Lawn and turf seed mixtures.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Lawn and turf seed mixtures. 201.12a Section 201.12a..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling Agricultural Seeds § 201.12a Lawn and turf seed mixtures. Seed mixtures intended for...

  18. 7 CFR 201.73 - Processors and processing of all classes of certified seed.

    Science.gov (United States)

    2010-01-01

    ... seed. 201.73 Section 201.73 Agriculture Regulations of the Department of Agriculture (Continued... (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.73 Processors and processing of all classes of certified seed. The following requirements must be met by processors of all...

  19. 20 CFR 416.201 - General definitions and terms used in this subpart.

    Science.gov (United States)

    2010-04-01

    ... subpart. 416.201 Section 416.201 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Eligibility General § 416.201 General definitions and terms used... substantially all of his or her food and shelter while living in a public institution. The person need not...

  20. 48 CFR 201.109 - Statutory acquisition-related dollar thresholds-adjustment for inflation.

    Science.gov (United States)

    2010-10-01

    ...-related dollar thresholds-adjustment for inflation. 201.109 Section 201.109 Federal Acquisition... REGULATIONS SYSTEM Purpose, Authority, Issuance 201.109 Statutory acquisition-related dollar thresholds-adjustment for inflation. (d) A matrix showing the most recent escalation adjustments of...

  1. 13 CFR 126.201 - Who does SBA consider to own a HUBZone SBC?

    Science.gov (United States)

    2010-01-01

    ... HUBZone SBC? 126.201 Section 126.201 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION HUBZONE PROGRAM Requirements to be a Qualified HUBZone SBC § 126.201 Who does SBA consider to own a HUBZone SBC? An owner of a SBC seeking HUBZone certification or a qualified HUBZone SBC is a person who owns...

  2. 41 CFR 50-201.1102 - Tolerance for apprentices, student-learners, and handicapped workers.

    Science.gov (United States)

    2010-07-01

    ..., student-learners, and handicapped workers. 50-201.1102 Section 50-201.1102 Public Contracts and Property... REGULATIONS § 50-201.1102 Tolerance for apprentices, student-learners, and handicapped workers. (a... standards and procedures as are prescribed for the employment of apprentices, student-learners,...

  3. 4 CFR 201.3 - Publicly available documents and electronic reading room.

    Science.gov (United States)

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Publicly available documents and electronic reading room. 201.3 Section 201.3 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PUBLIC INFORMATION AND REQUESTS § 201.3 Publicly available documents and electronic reading room. (a) Many Board records...

  4. 21 CFR 201.200 - Disclosure of drug efficacy study evaluations in labeling and advertising.

    Science.gov (United States)

    2010-04-01

    ... labeling and advertising. 201.200 Section 201.200 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT... Efficacy Study § 201.200 Disclosure of drug efficacy study evaluations in labeling and advertising. (a)(1...), promotional labeling, and advertisements shall include, as part of the information for practitioners...

  5. 40 CFR 246.201-6 - Recommended procedures: Transportation to market.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Transportation to market. 246.201-6 Section 246.201-6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Procedures § 246.201-6 Recommended procedures: Transportation to market. Transportation to market may...

  6. 47 CFR 54.201 - Definition of eligible telecommunications carriers, generally.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Definition of eligible telecommunications carriers, generally. 54.201 Section 54.201 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED... § 54.201 Definition of eligible telecommunications carriers, generally. (a) Carriers eligible...

  7. 9 CFR 201.100 - Records to be furnished poultry growers and sellers.

    Science.gov (United States)

    2010-01-01

    ... growers and sellers. 201.100 Section 201.100 Animals and Animal Products GRAIN INSPECTION, PACKERS AND... poultry growers and sellers. Link to an amendment published at 74 FR 63277, Dec. 3, 2009. (a) Contracts... forth as follows: § 201.100 Records to be furnished poultry growers and sellers. (a) Poultry...

  8. 31 CFR 560.201 - Prohibited importation of goods or services from Iran.

    Science.gov (United States)

    2010-07-01

    ... services from Iran. 560.201 Section 560.201 Money and Finance: Treasury Regulations Relating to Money and... REGULATIONS Prohibitions § 560.201 Prohibited importation of goods or services from Iran. Except as otherwise... origin or owned or controlled by the Government of Iran, other than information and...

  9. 40 CFR 267.201 - What must I do when I stop operating the tank system?

    Science.gov (United States)

    2010-07-01

    ... OPERATING UNDER A STANDARDIZED PERMIT Tank Systems § 267.201 What must I do when I stop operating the tank... 40 Protection of Environment 26 2010-07-01 2010-07-01 false What must I do when I stop operating the tank system? 267.201 Section 267.201 Protection of Environment ENVIRONMENTAL PROTECTION...

  10. 19 CFR 201.6 - Confidential business information.

    Science.gov (United States)

    2010-04-01

    ... business information (e.g., discussion of trends) will be treated as confidential business information only... business information shall be addressed to the Secretary, United States International Trade Commission, 500... 19 Customs Duties 3 2010-04-01 2010-04-01 false Confidential business information. 201.6...

  11. 5 CFR 315.201 - Service requirement for career tenure.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Service requirement for career tenure... REGULATIONS CAREER AND CAREER-CONDITIONAL EMPLOYMENT The Career-Conditional Employment System § 315.201 Service requirement for career tenure. (a) Service requirement. A person employed in the...

  12. 22 CFR 201.32 - Suppliers of delivery services.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Suppliers of delivery services. 201.32 Section... services. (a) Performance of the service contract. The supplier of delivery services financed by USAID shall comply with the terms and conditions of its contract to supply delivery services. (b)...

  13. 48 CFR 614.201-70 - Use of English language.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Use of English language... METHODS AND CONTRACT TYPES SEALED BIDDING Solicitation of Bids 614.201-70 Use of English language. Use of English language solicitations and contracts is mandatory unless a deviation has been approved by...

  14. 22 CFR 201.82 - Rights of USAID against suppliers.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Rights of USAID against suppliers. 201.82... of USAID against suppliers. Without limiting the responsibility of the borrower/grantee or other parties, USAID may require an appropriate refund to it by a supplier under any transaction which...

  15. Thallium-201 scintigraphy for bone and soft tissue tumors

    Energy Technology Data Exchange (ETDEWEB)

    Tokuumi, Yuji; Tsuchiya, Hiroyuki; Sunayama, Chiaki; Matsuda, Eizo; Asada, Naohiro; Taki, Junichi; Sumiya, Hisashi; Miyauchi, Tsutomu; Tomita, Katsuro [Kanazawa Univ. (Japan). School of Medicine

    1995-05-01

    This study was undertaken to assess the usefulness of thallium-201 scintigraphy in bone and soft tissue tumors. Pre-therapy scintigraphy was undertaken in a total of 136 patients with histologically confirmed diagnosis, consisting of 74 with malignant bone and soft tissue tumors, 39 with benign ones, 12 with diseases analogous to tumors, and 11 others. Thallium activity was graded on a scale of 0-4: 0=background activity, 1=equivocal activity, 2=definitive activity, but less than myocardium, 3=definite activity equal to myocardium, and 4=activity greater than myocardium. In the group of malignant tumors, thallium-201 uptake was found in 80%, although it was low for chondrosarcoma (2/8) and malignant Schwannoma (one/3). The group of benign tumors, however, showed it in only 41%, being restricted to those with giant cell tumors, chondroblastoma, fibromatosis, and osteoid osteoma. Thallium-201 uptake was also found in all 8 patients with metastatic tumors. In 23 patients undergoing thallium imaging before and after chemotherapy, scintigraphic findings revealed a high correlation with histopathological findings. Thus, thallium-201 scintigraphy may be potentially used to distinguish malignant from benign bone and soft tissue tumors, except for a few histopathological cases, as well as to determine loco-regional metastases and response to chemotherapy. (N.K.).

  16. 12 CFR 201.1 - Authority, purpose and scope.

    Science.gov (United States)

    2010-01-01

    ... applies to United States branches and agencies of foreign banks that are subject to reserve requirements....1 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM EXTENSIONS OF CREDIT BY FEDERAL RESERVE BANKS (REGULATION A) § 201.1 Authority, purpose and scope....

  17. 9 CFR 201.42 - Custodial accounts for trust funds.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Custodial accounts for trust funds... STOCKYARDS ACT Proceeds of Sale § 201.42 Custodial accounts for trust funds. (a) Payments for livestock are trust funds. Each payment that a livestock buyer makes to a market agency selling on commission is...

  18. 40 CFR 240.201-2 - Recommended procedures: Design.

    Science.gov (United States)

    2010-07-01

    ... carcasses, automobile bodies, dewatered sludges from water treatment plants, and industrial process wastes. ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Recommended procedures: Design. 240... § 240.201-2 Recommended procedures: Design. (a) Provision for storing, handling, and removing...

  19. 9 CFR 93.201 - General prohibitions; exceptions.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false General prohibitions; exceptions. 93...; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Poultry § 93.201 General prohibitions; exceptions... theatrical poultry that have been in any region where highly pathogenic avian influenza subtype H5N1...

  20. 48 CFR 1536.201 - Evaluation of contracting performance.

    Science.gov (United States)

    2010-10-01

    ... Contracting for Construction 1536.201 Evaluation of contracting performance. (a) The Contracting Officer will... will file the form in the contractor performance evaluation files which it maintains. (e) The Quality... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Evaluation of...

  1. 48 CFR 36.201 - Evaluation of contractor performance.

    Science.gov (United States)

    2010-10-01

    ... Contracting for Construction 36.201 Evaluation of contractor performance. See 42.1502(e) for the requirements for preparing past performance evaluations for construction contracts. ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Evaluation of...

  2. 48 CFR 236.201 - Evaluation of contractor performance.

    Science.gov (United States)

    2010-10-01

    ... CONTRACTS Special Aspects of Contracting for Construction 236.201 Evaluation of contractor performance. (a) Preparation of performance evaluation reports. Use DD Form 2626, Performance Evaluation (Construction... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Evaluation of...

  3. 24 CFR 401.201 - How does HUD select PAEs?

    Science.gov (United States)

    2010-04-01

    ... (MARK-TO-MARKET) Participating Administrative Entity (PAE) and Portfolio Restructuring Agreement (PRA) § 401.201 How does HUD select PAEs? (a) Selection of PAE. HUD will select qualified PAEs in accordance... responsibility for projects in the jurisdiction. If the agencies are unable to agree, HUD will choose a PAE...

  4. 27 CFR 25.201 - Removal by pipeline.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Removal by pipeline. 25... Distilled Spirits Plant § 25.201 Removal by pipeline. A brewer may remove beer from the brewery, without payment of tax, by pipeline to the bonded premises of a distilled spirits plant which is authorized...

  5. 33 CFR 127.201 - Sensing and alarm systems.

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) WATERFRONT FACILITIES WATERFRONT FACILITIES HANDLING LIQUEFIED NATURAL GAS AND LIQUEFIED HAZARDOUS GAS Waterfront Facilities Handling Liquefied Natural Gas Equipment § 127.201 Sensing and alarm systems. (a) Fixed sensors must have audio and visual alarms in the control room and audio alarms...

  6. 9 CFR 201.69 - Furnishing information to competitor buyers.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Furnishing information to competitor... STOCKYARDS ACT Trade Practices § 201.69 Furnishing information to competitor buyers. No packer, dealer, or... operations: (a) Furnish competitor packers, dealers, market agencies, or their buyers or...

  7. 44 CFR 201.6 - Local Mitigation Plans.

    Science.gov (United States)

    2010-10-01

    ... HOMELAND SECURITY DISASTER ASSISTANCE MITIGATION PLANNING § 201.6 Local Mitigation Plans. The local... essential to the development of an effective plan. In order to develop a more comprehensive approach to... appropriate, of existing plans, studies, reports, and technical information. (c) Plan content. The plan...

  8. 9 CFR 113.201 - Canine Distemper Vaccine, Killed Virus.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Canine Distemper Vaccine, Killed Virus... REQUIREMENTS Killed Virus Vaccines § 113.201 Canine Distemper Vaccine, Killed Virus. Canine Distemper Vaccine... canine distemper susceptible dogs (20 vaccinates and 5 controls) shall be used as test animals....

  9. 47 CFR 2.201 - Emission, modulation, and transmission characteristics.

    Science.gov (United States)

    2010-10-01

    ... ALLOCATIONS AND RADIO TREATY MATTERS; GENERAL RULES AND REGULATIONS Emissions § 2.201 Emission, modulation... frequency emissions, continuous wave and pulse radars, etc. (1) No information transmitted N (2) Telegraphy... principles, damped waves are symbolized in the Commission's rules and regulations as type B emission. The...

  10. 42 CFR 84.201 - Head harnesses; minimum requirements.

    Science.gov (United States)

    2010-10-01

    ... Cartridge Respirators § 84.201 Head harnesses; minimum requirements. (a)(1) Facepieces for chemical cartridge respirators other than single-use vinyl chloride shall be equipped with adjustable and replaceable... chloride respirators shall be equipped with adjustable head harnesses designed and constructed to...

  11. 7 CFR 1160.201 - Term of office.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE FLUID MILK PROMOTION PROGRAM Fluid Milk Promotion Order National Fluid Milk Processor Promotion Board § 1160.201 Term of office. (a) The members of the Board...

  12. 29 CFR 778.201 - Overtime premiums-general.

    Science.gov (United States)

    2010-07-01

    ... POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS OVERTIME COMPENSATION Payments That May Be Excluded From the âRegular Rateâ Extra Compensation Paid for Overtime § 778.201 Overtime premiums—general..., the extra compensation provided by the premium rates need not be included in the employee's...

  13. 4 CFR 201.7 - Timing of responses to requests.

    Science.gov (United States)

    2010-01-01

    ... Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PUBLIC INFORMATION AND REQUESTS § 201.7 Timing of... disclosed in part shall be marked or annotated to show the amount of information deleted unless doing so would harm an interest protected by an applicable exemption. The location of the information...

  14. 48 CFR 941.201-71 - Use of subcontracts.

    Science.gov (United States)

    2010-10-01

    ... CATEGORIES OF CONTRACTING ACQUISITION OF UTILITY SERVICES Acquiring Utility Services 941.201-71 Use of... and/or sewerage at facilities owned or leased by DOE shall not be acquired under a subcontract arrangement, except as provided for at 970.4102-1 or if the prime contract is with a utility company....

  15. 18 CFR 367.2010 - Account 201, Common stock issued.

    Science.gov (United States)

    2010-04-01

    ... GAS ACT Balance Sheet Chart of Accounts Proprietary Capital § 367.2010 Account 201, Common stock... stock issued. 367.2010 Section 367.2010 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE PUBLIC UTILITY HOLDING COMPANY ACT OF...

  16. 21 CFR 201.56 - Requirements on content and format of labeling for human prescription drug and biological products.

    Science.gov (United States)

    2010-04-01

    ... human prescription drug and biological products. 201.56 Section 201.56 Food and Drugs FOOD AND DRUG... human prescription drug and biological products. (a) General requirements. Prescription drug labeling... requirements in §§ 201.56(d) and 201.57. (1) The following categories of prescription drug products are...

  17. Verification of RESRAD-RDD. (Version 2.01)

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Jing-Jy [Argonne National Lab. (ANL), Argonne, IL (United States); Flood, Paul E. [Argonne National Lab. (ANL), Argonne, IL (United States); LePoire, David [Argonne National Lab. (ANL), Argonne, IL (United States); Kamboj, Sunita [Argonne National Lab. (ANL), Argonne, IL (United States); Yu, Charley [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-01

    In this report, the results generated by RESRAD-RDD version 2.01 are compared with those produced by RESRAD-RDD version 1.7 for different scenarios with different sets of input parameters. RESRAD-RDD version 1.7 is spreadsheet-driven, performing calculations with Microsoft Excel spreadsheets. RESRAD-RDD version 2.01 revamped version 1.7 by using command-driven programs designed with Visual Basic.NET to direct calculations with data saved in Microsoft Access database, and re-facing the graphical user interface (GUI) to provide more flexibility and choices in guideline derivation. Because version 1.7 and version 2.01 perform the same calculations, the comparison of their results serves as verification of both versions. The verification covered calculation results for 11 radionuclides included in both versions: Am-241, Cf-252, Cm-244, Co-60, Cs-137, Ir-192, Po-210, Pu-238, Pu-239, Ra-226, and Sr-90. At first, all nuclidespecific data used in both versions were compared to ensure that they are identical. Then generic operational guidelines and measurement-based radiation doses or stay times associated with a specific operational guideline group were calculated with both versions using different sets of input parameters, and the results obtained with the same set of input parameters were compared. A total of 12 sets of input parameters were used for the verification, and the comparison was performed for each operational guideline group, from A to G, sequentially. The verification shows that RESRAD-RDD version 1.7 and RESRAD-RDD version 2.01 generate almost identical results; the slight differences could be attributed to differences in numerical precision with Microsoft Excel and Visual Basic.NET. RESRAD-RDD version 2.01 allows the selection of different units for use in reporting calculation results. The results of SI units were obtained and compared with the base results (in traditional units) used for comparison with version 1.7. The comparison shows that RESRAD

  18. Uptake of thallium-201 in enlarged thyroid glands. Concise communication

    Energy Technology Data Exchange (ETDEWEB)

    Fukuchi, M.; Kido, A.; Hyodo, K.; Tachibana, K.; Onoue, K.; Morita, T.; Nagai, K.

    1979-08-01

    We have investigated the thyroid uptake of Tl-201 in 37 patients with various types of goiter, and in six with normal thyroids. Significant thallium uptake was found in all cases in which there was thyroid enlargement, including Graves' disease, toxic thyroid nodule, primary hypothyroidism, simple goiter, Hashimoto's disease, thyroid carcinoma, and thyroid adenoma. If goiter was absent, however, there was no demonstrable uptake - e.g., in secondary hypothyroidism, subacute thyroiditis, and the normal controls. Thallium uptake did not correlate with thyroid function tests such as BMR, T/sub 3/-RU, T/sub 3/, T/sub 4/, TSH, antithyroid antibodies, or the 24-hr I-131 uptake. In 23 patients with diffuse goiter, on the other hand, maximum Tl-201 uptake correlated well with thyroid weight: r = 0.836 (p < 0.001); y = 0.02 x + 0.06.

  19. Calcitonin, as SMS 201-995, ameliorates the VIPoma syndrome.

    Science.gov (United States)

    Antonelli, A; Gambuzza, C; Bertoni, F; Baschieri, L

    1993-01-01

    A 72-year-old woman was referred to our hospital for diarrhea, abdominal and back pain, weight loss, low serum potassium level. Pathological findings and high circulating Vasoactive Intestinal Peptide (VIP) levels allowed us to diagnose "VIPoma syndrome". The patient underwent a treatment with SMS 201-995 with improvement of symptomatology and reduction of circulating VIP levels. After a wash-out period the patient was treated with salmon calcitonin with a net improvement of diarrhea, normalization of potassium serum level and reduction of VIP level. The symptomatology recurred after calcitonin withdrawal. These data confirm the effectiveness of SMS 201-995 in the VIPoma syndrome and suggest that calcitonin may ameliorate symptomatology and reduce circulating VIP level in patients with VIPoma tumor.

  20. Use of intravenous dipyridamole in thallium 201 myocardial perfusion imaging

    Energy Technology Data Exchange (ETDEWEB)

    Zeller, F.P.; Blend, M.J.

    1987-01-01

    Thallium 201 myocardial perfusion imaging is a standard method of evaluating regional myocardial blood flow. Myocardial perfusion is best evaluated at rest and during exercise, however, alternative methods have been sought to increase coronary blood flow in patients incapable of performing adequate exercise. A promising new method is the use of intravenous dipyridamole for pharmacologic stress imaging. It has distinct advantages over traditional treadmill exercise testing. The primary advantage of combining intravenous dipyridamole and thallium 201 is for testing patients in whom exercise is impractical or contraindicated. Examples include patients taking beta blockers and those who have had myocardial infarction or have severe peripheral vascular disease. To date, this agent has been available only to clinical investigators in approved protocols. With continued success, it should be approved for general use in the near future. 33 references.

  1. The X-38 V-201 Fin Fold Actuation Mechanism

    Science.gov (United States)

    Lupo, Christian; Robertson, Brandan; Gafka, George

    2004-01-01

    The X-38 Vehicle 201 (V-201) is a space flight prototype lifting body vehicle that was designed to launch to orbit in the Space Shuttle orbiter payload bay. Although the project was cancelled in May 2003, many of the systems were nearly complete. This paper will describe the fin folding actuation mechanism flight subsystems and development units as well as lessons learned in the design, assembly, development testing, and qualification testing. The two vertical tail fins must be stowed (folded inboard) to allow the orbiter payload bay doors to close. The fin folding actuation mechanism is a remotely or extravehicular activity (EVA) actuated single fault tolerant system consisting of seven subsystems capable of repeatedly deploying or stowing the fins.

  2. Clinical and experimental studies concerned with /sup 201/Tl-scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Umeda, Tohru; Takada, Norihiko; Hotaka, Eiji (Chiba Cancer Center Hospital (Japan)); Inoue, Shunichi; Endo, Fujinori

    1982-07-01

    Basic autoradiographic study demonstrated that /sup 201/Tl concentrated in the area of increased proliferation of the cells. On diagnosis of bone lesions, /sup 201/Tl-scintigram showed a higher specificity than sup(99m)Tc-MDP-bone scintigram, and negative results of /sup 201/Tl-scintigraphy was highly suggestive of benign changes. However, positive results were sometimes obtained from benign lesions and negative results from malignant ones. /sup 201/Tl-scintigram was useful in differentiating compression fracture or inflammation from malignant lesions, observing the effect of radiation therapy, revealing the metastasis of thyroid carcinoma, and according to literature, in detecting the recurrence of giant cell tumor. /sup 201/Tl-scintigram provides information different from that of bone-scintigram in the extremity and the superficial area, because of rapid clearance of /sup 201/Tl, and it is thought to be useful for screening.

  3. Preparation of Rh[16aneS4-diol](211)At and Ir[16aneS4-diol](211)At complexes as potential precursors for astatine radiopharmaceuticals. Part I: Synthesis.

    Science.gov (United States)

    Pruszyński, Marek; Bilewicz, Aleksander; Zalutsky, Michael R

    2008-04-01

    The goal of this study was to evaluate a new approach that can be applied for labeling biomolecules with (211)At. Many astatine compounds that have been synthesized are unstable in vivo, providing motivation for seeking different (211)At labeling strategies. The approach evaluated in this study was to attach astatide anions to soft metal cations, which are also complexed by a bifunctional ligand. Ultimately, this complex could in principle be subsequently conjugated to a biomolecule with the proper selection of ligand functionality. We report here the attachment of (211)At(-) and *I(-) (*I = (131)I or (125)I) anions to the soft metal cations Rh(III) and Ir(III), which are complexed by the 1,5,9,13-tetrathiacyclohexadecane-3,11-diol (16aneS4-diol) ligand. Radioactive *I(-) anions were used for preliminary studies directed at the optimization of reaction conditions and to provide a baseline for comparison of results with (211)At. Four complexes Rh[16aneS4-diol]*I/(211)At and Ir[16aneS4-diol]*I/(211)At were synthesized in high yield in a one-step procedure, and the products were characterized mainly by paper electrophoresis and reversed-phase HPLC. The influences of time and temperature of heating and concentrations of metal cations and sulfur ligand 16aneS4-diol, as well as pH on the reaction yields were determined. Yields of about 80% were obtained when the quantities of Rh(III) or Ir(III) cations and 16aneS4-diol ligand in the solutions were 62.5 nmol and 250 nmol, respectively, and the pH ranged 3.0-4.0. Syntheses required heating for 1-1.5 h at 75-80 degrees C. The influence of microwave heating on the time and completeness of the complexation reaction was evaluated and compared with the conventional method of heating in an oil bath. Microwave synthesis accelerates reactions significantly. With microwave heating, yields of about 75% for Rh[16aneS4-diol](131)I and Ir[16aneS4-diol](131)I complexes were obtained after only 20 min exposure of the reaction mixtures to

  4. 37 CFR 201.6 - Payment and refund of Copyright Office fees.

    Science.gov (United States)

    2010-07-01

    ... Copyright Office fees. 201.6 Section 201.6 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF... letters or packages will be at the remitter's risk. Remittances from foreign countries should be in the... retained in the Copyright Office, transferred for the permanent collections or other uses of the Library...

  5. 17 CFR 201.630 - Inability to pay disgorge-ment, interest or penalties.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Inability to pay disgorge-ment, interest or penalties. 201.630 Section 201.630 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... Inability to pay disgorge-ment, interest or penalties. (a) Generally. In any proceeding in which an...

  6. 21 CFR 201.161 - Carbon dioxide and certain other gases.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Carbon dioxide and certain other gases. 201.161... (CONTINUED) DRUGS: GENERAL LABELING Other Exemptions § 201.161 Carbon dioxide and certain other gases. (a) Carbon dioxide, cyclopropane, ethylene, helium, and nitrous oxide gases intended for drug use...

  7. 14 CFR 1221.201 - Basis for award of the medal.

    Science.gov (United States)

    2010-01-01

    ... be awarded to any person who is or has been designated to travel in space and who has distinguished... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Basis for award of the medal. 1221.201 Section 1221.201 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION THE NASA SEAL...

  8. Excessive grooming induced by somatostatin or its analog SMS 201-995

    NARCIS (Netherlands)

    Wimersma Greidanus, T.B. van; Maigret, C.; Krechting, B.

    1987-01-01

    Intracerebroventricular (i.c.v.) administration of somatostatin or SMS 201-995 induces excessive grooming behavior in rats. The grooming inducing effect of somatostatin is rather weak, as doses of 300 ng or less did not result in increased total grooming scores. In contrast a dose of 10 ng SMS 201-9

  9. 7 CFR 201.31 - Germination standards for vegetable seeds in interstate commerce.

    Science.gov (United States)

    2010-01-01

    ... interstate commerce. 201.31 Section 201.31 Agriculture Regulations of the Department of Agriculture... Germination standards for vegetable seeds in interstate commerce. The following germination standards for vegetable seeds in interstate commerce, which shall be construed to include hard seed, are determined...

  10. 40 CFR 1039.201 - What are the general requirements for obtaining a certificate of conformity?

    Science.gov (United States)

    2010-07-01

    ... obtaining a certificate of conformity? 1039.201 Section 1039.201 Protection of Environment ENVIRONMENTAL... obtaining a certificate of conformity? (a) You must send us a separate application for a certificate of conformity for each engine family. A certificate of conformity is valid from the indicated effective...

  11. 40 CFR 1042.201 - General requirements for obtaining a certificate of conformity.

    Science.gov (United States)

    2010-07-01

    ... certificate of conformity. 1042.201 Section 1042.201 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... of conformity. (a) You must send us a separate application for a certificate of conformity for each engine family. A certificate of conformity is valid starting with the indicated effective date, but it...

  12. 40 CFR 1048.201 - What are the general requirements for obtaining a certificate of conformity?

    Science.gov (United States)

    2010-07-01

    ... obtaining a certificate of conformity? 1048.201 Section 1048.201 Protection of Environment ENVIRONMENTAL... certificate of conformity? (a) You must send us a separate application for a certificate of conformity for each engine family. A certificate of conformity is valid starting with the indicated effective...

  13. 40 CFR 1045.201 - What are the general requirements for obtaining a certificate of conformity?

    Science.gov (United States)

    2010-07-01

    ... obtaining a certificate of conformity? 1045.201 Section 1045.201 Protection of Environment ENVIRONMENTAL... obtaining a certificate of conformity? Engine manufacturers must certify their engines with respect to the... conformity: (a) You must send us a separate application for a certificate of conformity for each...

  14. 48 CFR 315.201 - Exchanges with industry before receipt of proposals.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Exchanges with industry before receipt of proposals. 315.201 Section 315.201 Federal Acquisition Regulations System HEALTH AND... uncertain whether any organization, acting individually or in partnership with others, can satisfy...

  15. 46 CFR 201.137 - Rights of parties as to presentation of evidence.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Rights of parties as to presentation of evidence. 201.137 Section 201.137 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE... presentation of evidence. Every party shall have the right to present his case or defense by oral...

  16. 9 CFR 201.44 - Market agencies to render prompt accounting for purchases on order.

    Science.gov (United States)

    2010-01-01

    ... accounting for purchases on order. 201.44 Section 201.44 Animals and Animal Products GRAIN INSPECTION... prompt accounting for purchases on order. Each market agency shall, promptly following the purchase of livestock on a commission or agency basis, transmit or deliver to the person for whose account such...

  17. The long-acting somatostatin analogue SMS 201-995 causes malabsorption

    DEFF Research Database (Denmark)

    Witt, K; Pedersen, N T

    1989-01-01

    Somatostatin and its long-acting analogue SMS 201-995 (Sandostatin) have been suspected of causing steatorrhoea. The aim of this study was to examine the effect of SMS 201-995 on fat assimilation in healthy subjects, using 14C-triolein and 3H-oleic acid as tracers of dietary triglycerides and free...

  18. 48 CFR 53.201-1 - Contracting authority and responsibilities (SF 1402).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contracting authority and responsibilities (SF 1402). 53.201-1 Section 53.201-1 Federal Acquisition Regulations System FEDERAL ACQUISITION... responsibilities (SF 1402). SF 1402 (10/83), Certificate of Appointment. SF 1402 is prescribed for use...

  19. 48 CFR 853.201-1 - Contracting authority and responsibilities (SF 1402).

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting authority and responsibilities (SF 1402). 853.201-1 Section 853.201-1 Federal Acquisition Regulations System DEPARTMENT OF... responsibilities (SF 1402). Standard Form (SF) 1402, Certificate of Appointment, is used in accordance with FAR...

  20. 22 CFR 201.62 - Responsibilities of borrower/grantee and of supplier.

    Science.gov (United States)

    2010-04-01

    ... supplier. 201.62 Section 201.62 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES AND PROCEDURES.../grantee and of supplier. (a) Responsibilities of borrower/grantee. The borrower/grantee shall: (1) When... price, including transportation cost, for the commodity. (b) Responsibility of supplier. In...

  1. 30 CFR 243.201 - How will MMS determine if I am financially solvent?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How will MMS determine if I am financially solvent? 243.201 Section 243.201 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT SUSPENSIONS PENDING APPEAL AND BONDING-MINERALS REVENUE MANAGEMENT...

  2. 7 CFR 201.56-6 - Legume or pea family, Fabaceae (Leguminosae).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Legume or pea family, Fabaceae (Leguminosae). 201.56-6 Section 201.56-6 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL...-6 Legume or pea family, Fabaceae (Leguminosae). Kinds of seed: Alfalfa, alyceclover,...

  3. 7 CFR 201.74 - Labeling of all classes of certified seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Labeling of all classes of certified seed. 201.74... SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.74 Labeling of all classes of certified seed....

  4. 7 CFR 201.70 - Limitations of generations for certified seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Limitations of generations for certified seed. 201.70... SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.70 Limitations of generations for certified...

  5. 7 CFR 201.72 - Production of all classes of certified seed.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Production of all classes of certified seed. 201.72... SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.72 Production of all classes of certified...

  6. 7 CFR 201.67 - Seed certifying agency standards and procedures.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Seed certifying agency standards and procedures. 201...) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.67 Seed certifying agency standards and procedures. In order to qualify as a seed certifying agency for purposes of section 101(a)(25) of the...

  7. 7 CFR 201.17 - Noxious-weed seeds in the District of Columbia.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Noxious-weed seeds in the District of Columbia. 201.17... ACT FEDERAL SEED ACT REGULATIONS Labeling Agricultural Seeds § 201.17 Noxious-weed seeds in the District of Columbia. (a) Noxious-weed seeds in the District of Columbia are: Quackgrass (Elytrigia...

  8. Fast washout of thallium-201 from area of myocardial infarction: possible artifact of background subtraction

    Energy Technology Data Exchange (ETDEWEB)

    Brown, K.A.; Benoit, L.; Clements, J.P.; Wackers, F.J.

    1987-06-01

    A recent report described a pattern of reverse redistribution on poststreptokinase /sup 201/Tl studies which was believed to be due to rapid washout of /sup 201/Tl from the infarct area related to reperfusion of the infarct vessel. We have also observed the phenomenon of rapid washout of /sup 201/Tl from the area of infarction in the absence of thrombolytic therapy. This study was undertaken to test the hypothesis that rapid washout of /sup 201/Tl from an area of infarction is an artifact of background subtraction usually employed in analysis of washout. A total of 61 patients with previous myocardial infarction who underwent cardiac catheterization and exercise /sup 201/Tl imaging were examined. Thallium-201 images were analyzed using a validated quantitative method employing interpolative background correction. Abnormally increased /sup 201/Tl washout was noted in 11 infarct segments in 10 (18%) patients. Infarct segments with rapid washout had significantly less initial uptake, and more severe associated wall motion abnormalities than infarct segments with normal washout. When quantitative analysis was repeated without background subtraction, no segments with rapid washout were observed. A phantom model was constructed to further test our hypothesis. The frequency of observed rapid washout was directly related to the severity of the initial defect and was entirely dependent upon utilizing background correction during the quantitative analysis. Our study suggests that rapid washout of /sup 201/Tl in an area of previous infarction reflects an artifact of background subtraction involved with standard quantitative analysis.

  9. 21 CFR 201.125 - Drugs for use in teaching, law enforcement, research, and analysis.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Drugs for use in teaching, law enforcement... § 201.125 Drugs for use in teaching, law enforcement, research, and analysis. A drug subject to § 201... possession of, persons regularly and lawfully engaged in instruction in pharmacy, chemistry, or medicine...

  10. 3 CFR - Delegation of Certain Functions Under Section 201 of Public Law 110-429

    Science.gov (United States)

    2010-01-01

    ... Public Law 110-429 Presidential Documents Other Presidential Documents Memorandum of June 8, 2009 Delegation of Certain Functions Under Section 201 of Public Law 110-429 Memorandum for the Secretary of State... conferred upon the President by subsections (a), (b), and (c) of section 201 of Public Law 110-429. You...

  11. 9 CFR 201.43 - Payment and accounting for livestock and live poultry.

    Science.gov (United States)

    2010-01-01

    ... and live poultry. 201.43 Section 201.43 Animals and Animal Products GRAIN INSPECTION, PACKERS AND... poultry. (a) Market agencies to make prompt accounting and transmittal of net proceeds. Each market agency... nature of the transaction. (b) Prompt payment for livestock and live poultry—terms and conditions. (1)...

  12. 9 CFR 201.82 - Care and promptness in weighing and handling livestock and live poultry.

    Science.gov (United States)

    2010-01-01

    ... handling livestock and live poultry. 201.82 Section 201.82 Animals and Animal Products GRAIN INSPECTION... handling livestock and live poultry. (a) Each stockyard owner, market agency, dealer, packer and live poultry dealer shall exercise reasonable care and promptness with respect to loading,...

  13. 13 CFR 127.201 - What are the requirements for ownership of an EDWOSB and WOSB?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are the requirements for ownership of an EDWOSB and WOSB? 127.201 Section 127.201 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION WOMEN-OWNED SMALL BUSINESS FEDERAL CONTRACT ASSISTANCE PROCEDURES Eligibility Requirements...

  14. 37 CFR 201.27 - Initial notice of distribution of digital audio recording devices or media.

    Science.gov (United States)

    2010-07-01

    ... distribution of digital audio recording devices or media. 201.27 Section 201.27 Patents, Trademarks, and... Initial notice of distribution of digital audio recording devices or media. (a) General. This section..., any digital audio recording device or digital audio recording medium in the United States....

  15. 37 CFR 201.9 - Recordation of agreements between copyright owners and public broadcasting entities.

    Science.gov (United States)

    2010-07-01

    ... between copyright owners and public broadcasting entities. 201.9 Section 201.9 Patents, Trademarks, and... Recordation of agreements between copyright owners and public broadcasting entities. (a) License agreements... published pictorial, graphic, and sculptural works, and one or more public broadcasting entities, and...

  16. 13 CFR 134.201 - Scope of the rules in this subpart B.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Scope of the rules in this subpart B. 134.201 Section 134.201 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF... Fraud Civil Remedies Act are set forth, respectively in subpart D of this part and part 142 of...

  17. 7 CFR 900.201 - Investigation and disposition of alleged violations.

    Science.gov (United States)

    2010-01-01

    .... 900.201 Section 900.201 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF..., the provisions of any marketing order, he may institute such investigation and, after due notice...

  18. Investigation of Coronal Large Scale Structures Utilizing Spartan 201 Data

    Science.gov (United States)

    Guhathakurta, Madhulika

    1998-01-01

    Two telescopes aboard Spartan 201, a small satellite has been launched from the Space Shuttles, on April 8th, 1993, September 8th, 1994, September 7th, 1995 and November 20th, 1997. The main objective of the mission was to answer some of the most fundamental unanswered questions of solar physics-What accelerates the solar wind and what heats the corona? The two telescopes are 1) Ultraviolet Coronal Spectrometer (UVCS) provided by the Smithsonian Astrophysical Observatory which uses ultraviolet emissions from neutral hydrogen and ions in the corona to determine velocities of the coronal plasma within the solar wind source region, and the temperature and density distributions of protons and 2) White Light Coronagraph (WLC) provided by NASA's Goddard Space Flight Center which measures visible light to determine the density distribution of coronal electrons within the same region. The PI has had the primary responsibility in the development and application of computer codes necessary for scientific data analysis activities, end instrument calibration for the white-light coronagraph for the entire Spartan mission. The PI was responsible for the science output from the WLC instrument. PI has also been involved in the investigation of coronal density distributions in large-scale structures by use of numerical models which are (mathematically) sufficient to reproduce the details of the observed brightness and polarized brightness distributions found in SPARTAN 201 data.

  19. Thallium-201 buttock scans. Noninvasive testing for gluteal muscle ischemia

    Energy Technology Data Exchange (ETDEWEB)

    Toshima, Masahiro; Fujimura, Mitsuo; Nishiya, Yasushi; Shuuke, Noriji; Nakajima, Kenichi [Toyama Prefectural Central Hospital (Japan)

    1997-08-01

    To evaluate the perfusion of the gluteal muscle, single-photon emission computed tomography (SPECT) using thallium-201 was performed in 23 patients of arteriosclerotic obstructive disease. The SPECT image of the buttock was obtained by a rotating digital gamma camera on the prone position. Patients underwent treadmill exercise until buttock or leg pain appeared, of which 17 patients complained buttock pain. The transaxial stress and redistribution images were analyzed and the uptake and washout rate were calculated in each segment of the gluteal muscle. The gluteal muscle was clearly visualized by the stress thallium SPECT. In the ischemic buttock, which was confirmed by angiography, the thallium uptake was significantly reduced compared with the normal buttock during exercise. The washout rate in the ischemic buttock was lower than that of the normal buttock and correlated with the degree of the stenosis of the internal iliac artery. The washout rate in the 16 patients with vasculogenic buttock claudication were under 10%. The vascular reconstruction improved buttock claudication, resulting in increase of the thallium uptake and washout rate of the ischemic gluteal muscle. The thallium-201 SPECT is useful to evaluate the perfusion of the gluteal muscles and the responsiveness to surgical treatment. (author)

  20. Evaluation of Tl-201 SPECT imaging findings in prostate cancer

    Directory of Open Access Journals (Sweden)

    Sinem Ozyurt

    2015-07-01

    Full Text Available Objectives: To compare with histopathological findings the findings of prostate cancer imaging by SPECT method using Tl-201 as a tumor seeking agent. Methods: The study comprised 59 patients (age range 51-79 years, mean age 65.3 ± 6.8 years who were planned to have transrectal ultrasonography (TRUS-guided biopsies due to suspicion of prostate cancer between April 2011 and September 2011. Early planar, late planar and SPECT images were obtained for all patients. Scintigraphic evaluation was made in relation to uptake presence and patterns in the visual assessment and to Tumor/Background (T/Bg ratios for both planar and SPECT images in the quantitative assessment. Histopathological findings were compatible with benign etiology in 36 (61% patients and malign etiology in 23 (39% patients. Additionally, comparisons were made to evaluate the relationships between uptake patterns,total PSA values and Gleason scores. Results: A statistically significant difference was found between the benign and malignant groups in terms of uptake in planar and SPECT images and T/Bg ratios and PSA values. No statistically significant difference was found between uptake patterns of planar and SPECT images and Gleason scores in the malignant group. Conclusions: SPECT images were superior to planar images in the comparative assessment. Tl-201 SPECT imaging can provide an additional contribution to clinical practice in the diagnosis of prostate cancer and it can be used in selected patients.

  1. 37 CFR 201.26 - Recordation of documents pertaining to computer shareware and donation of public domain computer...

    Science.gov (United States)

    2010-07-01

    ... pertaining to computer shareware and donation of public domain computer software. 201.26 Section 201.26... GENERAL PROVISIONS § 201.26 Recordation of documents pertaining to computer shareware and donation of public domain computer software. (a) General. This section prescribes the procedures for submission...

  2. 37 CFR 201.13 - Notices of objection to certain noncommercial performances of nondramatic literary or musical works.

    Science.gov (United States)

    2010-07-01

    ... certain noncommercial performances of nondramatic literary or musical works. 201.13 Section 201.13 Patents... PROVISIONS § 201.13 Notices of objection to certain noncommercial performances of nondramatic literary or... preventing the noncommercial performance of a nondramatic literary or musical work under...

  3. 14 CFR 11.201 - Office of Management and Budget (OMB) control numbers assigned under the Paperwork Reduction Act.

    Science.gov (United States)

    2010-01-01

    ... PROCEDURES Paperwork Reduction Act Control Numbers § 11.201 Office of Management and Budget (OMB) control... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Office of Management and Budget (OMB) control numbers assigned under the Paperwork Reduction Act. 11.201 Section 11.201 Aeronautics and...

  4. 49 CFR 1572.201 - Transportation of hazardous materials via commercial motor vehicle from Canada or Mexico to and...

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Transportation of hazardous materials via commercial motor vehicle from Canada or Mexico to and within the United States. 1572.201 Section 1572.201... Land Modes § 1572.201 Transportation of hazardous materials via commercial motor vehicle from Canada...

  5. 37 CFR 201.34 - Procedures for filing Correction Notices of Intent to Enforce a Copyright Restored under the...

    Science.gov (United States)

    2010-07-01

    ... prescribed in § 201.3(c). (2) Method of payment. See 37 CFR 201.33(e)(1),(2). (f) Public online access... Office History Documents (COHD) file through the Library of Congress electronic information system.... (3) Restored work. For the definition of works restored under the URAA, see 37 CFR 201.33. (c)...

  6. Role for threonine 201 in the catalytic cycle of the soluble diiron hydroxylase toluene 4-monooxygenase.

    Science.gov (United States)

    Elsen, Nathaniel L; Bailey, Lucas J; Hauser, Andrew D; Fox, Brian G

    2009-05-12

    The active site residue Thr-201 in toluene 4-monooxygenase hydroxylase (T4moH) has a structural counterpart in the active sites of all diiron monooxygenases. Thus, our previous finding that mutation of this residue to Ala, Gly, or Ser had no impact on steady-state catalysis or coupling was surprising. In this work, we provide kinetic, biochemical, and structural evidence that one role of Thr-201 may be to stabilize a peroxo-level intermediate during enzyme catalysis. During reactions in the absence of substrate, T201 T4moH slowly consumed O(2) but only a negligible amount of H(2)O(2) was released. In contrast, T201A T4moH gave stoichometric release of H(2)O(2) during reaction in the absence of substrate. Both enzyme isoforms were tightly coupled during steady-state catalysis with saturating toluene and other optimal substrates and exhibited near-identical kinetic parameters. However, rapid mix single-turnover studies showed that T201A T4moH had a faster first-order rate constant for product formation than T201 T4moH did. Comparison of X-ray crystal structures of resting and reduced T201A T4moH in complex with T4moD with comparable structures of T201 T4moHD revealed changes in the positions of several key active site residues relative to the comparable structures of T201 T4moH with T4moD. This combination of catalytic and structural studies offers important new insight into the role of the role of conserved Thr-201, and its contributions to the catalytic reaction cycle.

  7. Effectiveness of oblique section display in thallium-201 myocardial tomography

    Energy Technology Data Exchange (ETDEWEB)

    O' Brien, A.R.; Gemmell, H.G.

    1986-08-01

    A simple left ventricle phantom, placed in a water-filled body phantom, has been used to compare the detectability of simulated perfusion defects in short-axis oblique sections with transverse section tomography and conventional planar imaging. Images of the phantom were assessed by five experienced observers and their responses analysed on a lesion-by-lesion basis. No significant difference in defect detectability was found between planar imaging and transverse section tomography. However, following reorientation of the transverse section data into oblique planes perpendicular to the long-axis of the phantom there was a statistically significant increase in defect detectability compared with planar imaging. Observers also detected significantly more defects using oblique section display compared with the original transverse sections. This suggests that reformatting of the transverse sections into oblique planes may be essential to realize the full potential of thallium-201 myocardial tomography.

  8. Codon 201Gly Polymorphic Type of the DCC Gene is Related to Disseminated Neuroblastoma

    Directory of Open Access Journals (Sweden)

    Xiao-Tang Kong

    2001-01-01

    Full Text Available The deleted in colorectal carcinoma (DCC gene is a potential tumor- suppressor gene on chromosome 18821.3. The relatively high frequency of loss of heterozygosity (LOH and loss of expression of this gene in neuroblastoma, especially in the advanced stages, imply the possibility of involvement of the DCC gene in progression of neuroblastoma. However, only few typical mutations have been identified in this gene, indicating that other possible mechanisms for the inactivation of this gene may exist. A polymorphic change (Arg to Gly at DCC codon 201 is related to advanced colorectal carcinoma and increases in the tumors with absent DCC protein expression. In order to understand whether this change is associated with the development or progression of neuroblastoma, we investigated codon 201 polymorphism of the DCC gene in 102 primary neuroblastomas by polymerase chain reaction single-strand conformation polymorphism. We found no missense or nonsense mutations, but a polymorphic change from CGA (Arg to GGA (Gly at codon 201 resulting in three types of polymorphism: codon 201Gly type, codon 201Arg/Gly type, and codon 201Arg type. The codon 201Gly type occurred more frequently in disseminated (stages IV and IVs neuroblastomas (72% than in localized (stages I, II, and III tumors (48% (P=.035, and normal controls (38% (P=.024. In addition, the codon 201Gly type was significantly more common in tumors found clinically (65% than in those found by mass screening (35% (P=.002. The results suggested that the codon 201Gly type of the DCC gene might be associated with a higher risk of disseminating neuroblastoma.

  9. Intracoronary thallium-201 scintigraphy after thrombolytic therapy for acute myocardial infarction compared with 10 and 100 day intravenous thallium-201 scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Heller, G.V.; Parker, J.A.; Silverman, K.J.; Royal, H.D.; Kolodny, G.M.; Paulin, S.; Braunwald, E.; Markis, J.E.

    1987-02-01

    Thallium-201 imaging has been utilized to estimate myocardial salvage after thrombolytic therapy for acute myocardial infarction. However, results from recent animal studies have suggested that as a result of reactive hyperemia and delayed necrosis, thallium-201 imaging may overestimate myocardial salvage. To determine whether early overestimation of salvage occurs in humans, intracoronary thallium-201 scans 1 hour after thrombolytic therapy were compared with intravenous thallium-201 scans obtained approximately 10 and 100 days after myocardial infarction in 29 patients. In 10 patients with angiographic evidence of coronary reperfusion, immediate improvement in thallium defects and no interim clinical events, there was no change in imaging in the follow-up studies. Of nine patients with coronary reperfusion but no initial improvement of perfusion defects, none showed worsening of defects in the follow-up images. Six of these patients demonstrated subsequent improvement at either 10 or 100 days after infarction. Seven of 10 patients with neither early evidence of reperfusion nor improvement in perfusion defects had improvement of infarct-related perfusion defects, and none showed worsening. In conclusion, serial scanning at 10 and 100 days after infarction in patients with no subsequent clinical events showed no worsening of the perfusion image compared with images obtained in acute studies. Therefore, there is no evidence that thallium-201 imaging performed early in patients with acute myocardial infarction overestimates improvement.

  10. 201Tl+-labelled Prussian blue nanoparticles as contrast agents for SPECT scintigraphy

    Science.gov (United States)

    Perrier, M.; Busson, M.; Massasso, G.; Long, J.; Boudousq, V.; Pouget, J.-P.; Peyrottes, S.; Perigaud, Ch.; Porredon-Guarch, C.; de Lapuente, J.; Borras, M.; Larionova, J.; Guari, Y.

    2014-10-01

    Prussian blue (PB) and its analogues on the nanometric scale are exciting nano-objects that combine the advantages of molecular-based materials and nanochemistry. Herein, we demonstrate that ultra-small PB nanoparticles of 2-3 nm can be easily labelled with radioactive 201Tl+ to obtain new nanoprobes as radiotracers for 201-thallium-based imaging.Prussian blue (PB) and its analogues on the nanometric scale are exciting nano-objects that combine the advantages of molecular-based materials and nanochemistry. Herein, we demonstrate that ultra-small PB nanoparticles of 2-3 nm can be easily labelled with radioactive 201Tl+ to obtain new nanoprobes as radiotracers for 201-thallium-based imaging. Electronic supplementary information (ESI) available: Experimental details and procedures, toxicological data, PXRD, TEM images, kinetics and adsorption isotherms, SPECT/CT images, Tl+ captation profiles. See DOI: 10.1039/c4nr03044c

  11. 7 CFR 201.48 - Kind or variety considered pure seed.

    Science.gov (United States)

    2010-01-01

    ... 201.48 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED... remaining mass of tissue to be readily determined. Weevil-infested vetch seeds, irrespective of the...

  12. Role of thallium-201 total-body scintigraphy in follow-up of thyroid carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hoefnagel, C.A.; Delprat, C.C.; Marcuse, H.R.; de Vijlder, J.J.

    1986-12-01

    To evaluate the reliability of total-body scintigraphy using (/sup 201/Tl)chloride in postoperative follow-up of thyroid carcinoma, this procedure was performed in 326 patients after total thyroidectomy for thyroid carcinoma. The results were compared with those of 131I scintigraphy and thyroglobulin assays. /sup 201/Tl total-body scintigraphy was found to have the greatest sensitivity (94%), whereas /sup 131/I scintigraphy had the highest specificity (99%). It is shown that /sup 201/Tl total-body scintigraphy is a useful procedure in follow-up of thyroid cancer, however, the combination of parameters provides the greatest reliability. In medullary thyroid carcinoma, which is usually /sup 131/I negative, /sup 201/Tl total-body scintigraphy can be of great value for the localization of metastases which are indicated by elevated serum levels of calcitonin and carcinoembryonic antigen.

  13. 37 CFR 201.4 - Recordation of transfers and certain other documents.

    Science.gov (United States)

    2010-07-01

    ... and for digital audio recording devices and media (17 U.S.C. 111(d), 119(b) and 1003(c); see 37 CFR... or more public broadcasting entities and certain owners of copyright (17 U.S.C. 118; see 37 CFR 201.9... located outside of the 48 contiguous States (17 U.S.C. 111(e); see 37 CFR 201.12); (ii) Notices...

  14. Modulation improvements in the 201 MHZ RF generators at LAMPF

    Energy Technology Data Exchange (ETDEWEB)

    Parsons, W M; Lyles, J T.M.; Harris, H W

    1992-01-01

    Radio-frequency generators, operating at 201 MHz, power the first four stages of the Los Alamos Meson Physics Facility (LAMPF) accelerator. Each generator consists of four stages of seriesconnected, vacuum-tube amplifiers. The modulation scheme for each stage is different. The fist amplifier is a grid-modulated tetrode that produces 500 W peak-power. The second amplifier is a drive-modulated tetrode that produces 5 kill peak-power. The third stage is a grid- and plate-modulated tetrode that produces 130 kill peak-power. The last stage is a plate-modulated triode that produces 2.5 MW peak power. A modernization program has been initiated to improve the reliability of each of these stages. The first two stages of each generator are being replaced with a single, drive-modulated, solid-state amplifier. Specifications for the amplifier design, and requirements for integration into the system are presented. The third stage will be converted to a drive-modulated system using the current tetrode. This modification involves the development of a 17-kV, 15-A switching supply to replace the present plate-modulator. Design requirements for this switching supply are presented. The final stage will remain plate-modulated but will contain a new driver unit for the modulator tube.

  15. Lung uptake of thallium-201: a marker of defect reversibility?

    Science.gov (United States)

    Sanderson, R.; Woldman, S.; McCurrach, G.; Martin, W.; Hutton, I.

    1998-06-01

    High lung uptake of thallium-201 at stress is reported to be associated with a large number of perfusion defects and poor prognosis. This study was performed to assess whether the reversibility of stress perfusion defects was related to lung uptake. Gated planar thallium scans at stress and at redistribution from 102 consecutive patients with essentially normal left ventricular ejection fraction (using gated blood pool ventriculography) were graded in terms of defect size. Lung and myocardial uptake of thallium were quantitated by region of interest methods relative to the given activity in a previously validated method. There was no significant correlation (non-parametric) between lung uptake and degree of redistribution (). There was a weak but positive correlation between lung uptake and defect size (). Both exercise time and double product showed a negative correlation with lung uptake (e.g. for double product, ). In conclusion, contrary to our expectation, lung uptake is not related to the degree of redistribution. High lung uptake seems to reflect poor cardiovascular reserve.

  16. Mechanical properties of Inconel 718 and Nickel 201 alloys after thermal histories simulating brazing and high temperature service

    Science.gov (United States)

    James, W. F.

    1985-01-01

    An experimental investigation was made to evaluate two nickel base alloys (Nickel-201 and Inconel-718) in three heat treated conditions. These conditions were: (1) annealed; (2) after thermal exposure simulating a braze cycle; and (3) after a thermal exposure simulating a braze cycle plus one operational lifetime of high temperature service. For the Nickel-201, two different braze cycle temperatures were evaluated. A braze cycle utilizing a lower braze temperature resulted in less grain growth for Nickel-201 than the standard braze cycle used for joining Nickel-201 to Inconel-718. It was determined, however, that Nickel-201, was marginal for temperatures investigated due to large grain growth. After the thermal exposures described above, the mechanical properties of Nickel-201 were degraded, whereas similar exposure on Inconel-718 actually strengthened the material compared with the annealed condition. The investigation included tensile tests at both room temperature and elevated temperatures, stress-rupture tests, and metallographic examination.

  17. Effect of errors in reangulation on planar and tomographic thallium-201 washout profile curves

    Energy Technology Data Exchange (ETDEWEB)

    Lancaster, J.L.; Starling, M.R.; Kopp, D.T.; Lasher, J.C.; Blumhardt, R.

    1985-12-01

    Cardiac phantom studies were performed with and without a defect present to test the hypothesis that myocardial 201TI quantitative circumferential washout profile curves calculated from planar and rotating slant hole (RSH) collimator tomographic images are equally affected by errors in axial repositioning. Simulated stress images were acquired with the long axis of the phantom perpendicular to the camera surface and redistribution images were acquired to represent 50% 201TI washout with axial repositioning errors relative to the stress position ranging from 0 to 20 degrees in 5 degrees increments. There was a decrease in the 201TI washout profile curves compared to that expected (50%) in the wall tilted away from the camera surface, and a reciprocal increase in the 201TI washout profile curves in the wall tilted towards the camera surface for both imaging techniques whether a lesion was present or not. This effect became more pronounced as the error in axial repositioning was increased for both the planar (p less than 0.001) and the RSH tomographic (p less than 0.001) techniques. However, the deviation of the 201TI washout profile curves from that expected (50%) was greater for the planar imaging technique with or without a lesion (p less than 0.05 to 0.001). Thus, we conclude that 201TI quantitative circumferential washout profile curves calculated using this tomographic imaging technique are less affected by errors in axial repositioning than those calculated using an equivalent projection by standard planar imaging methods. These data emphasize the importance which must be placed on the repositioning of patients to obtain valid 201TI washout profile curves for the detection and localization of coronary artery disease.

  18. Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes

    Science.gov (United States)

    Chen, Y-J; Chen, Y-C; Wongcharoen, W; Lin, C-I; Chen, S-A

    2007-01-01

    Background and purpose: Pulmonary veins are the most important focus for the generation of atrial fibrillation. Abnormal calcium homeostasis with ryanodine receptor dysfunction may underlie the arrhythmogenic activity in pulmonary veins. The preferential ryanodine receptor stabilizer (K201) possesses antiarrhythmic effects through calcium regulation. The purpose of this study was to investigate the effects of K201 on the arrhythmogenic activity and calcium regulation of pulmonary vein cardiomyocytes. Experimental approach: The ionic currents and intracellular calcium were studied in isolated single cardiomyocytes from rabbit pulmonary vein before and after the administration of K201, by the whole-cell patch clamp and indo-1 fluorimetric ratio techniques. Key results: K201 (0.1, 0.3, 1 μM) reduced the firing rates in pulmonary vein cardiomyocytes, decreased the amplitudes of the delayed afterdepolarizations and prolonged the action potential duration. K201 decreased the L-type calcium currents, Na+/Ca2+ exchanger currents, transient inward currents and calcium transients. K201 (1 μM, but not 0.1 μM or 0.3 μM) also reduced the sarcoplasmic reticulum calcium content. Moreover, both the pretreatment and administration of K201 (0.3 μM) decreased the isoprenaline (10 nM)-induced arrhythmogenesis in pulmonary veins. Conclusions and implications: K201 reduced the arrhythmogenic activity of pulmonary vein cardiomyocytes and attenuated the arrhythmogenicity induced by isoprenaline. These findings may reveal the anti-arrhythmic potential of K201. PMID:17994112

  19. The usefulness of [sup 201]TlCl scintigraphy for the diagnosis of breast tumor

    Energy Technology Data Exchange (ETDEWEB)

    Takahashi, Tamami; Moriya, Etsuo; Miyamoto, Yukio; Kawakami, Kenji; Kubo, Hirotaka; Uchida, Takeshi (Jikei Univ., Tokyo (Japan). School of Medicine)

    1994-06-01

    The usefulness of [sup 201]TlCl SPECT (Tl SPECT) for the diagnosis of breast cancer was evaluated in 14 patients with various breast tumors (9 with invasive ductal carcinoma, 2 with fibroadenoma and 3 with benign process). These tumors ranged in size from 1.5 cm x 1.5 cm to 15.0 cm x 14.0 cm. Tl SPECT was carried out 2 hours after the intravenous injection of [sup 201]TlCl (185 MBq). For quantitative study, ROIs were set in the tumor (T), normal tissue of the opposite breast (B) and myocardium (M). Count ratios of T/B and T/M were calculated. Eight patients with breast cancer and a case of fibroadenoma showed intense accumulation of [sup 201]TlCl in the tumors. The T/B ratio was 1.20[+-]0.68 and the T/M ratio was 0.68[+-]0.31 in the 9 cases. Lymph node metastasis was detected in 2 of 6 cases that were confirmed at operation. No remarkable accumulation of [sup 201]TlCl was seen in 4 patients with benign process. One patient with benign tumor showed a false positive result. The rates of accuracy of mammography and ultrasonography for the same subjects were 82% and 84%, respectively. The results suggest that [sup 201]TlCl SPECT might be useful to assess breast cancer in cases in which the findings of other modalities are equivocal. (author).

  20. Evaluation of muscular lesions in connective tissue diseases: thallium 201 muscular scans

    Energy Technology Data Exchange (ETDEWEB)

    Guillet, G.; Guillet, J.; Sanciaume, C.; Maleville, J.; Geniaux, M.; Morin, P.

    1988-04-01

    We performed thallium 201 muscle scans to assess muscular involvement in 40 patients with different connective tissue diseases (7 with dermatomyositis, 7 with systemic lupus erythematosus, 12 with progressive systemic scleroderma, 2 with calcinosis, Raynaud's phenomenon, esophageal involvement, sclerodactyly, and telangiectasia (CREST) syndrome, 3 with monomelic scleroderma, 6 with morphea, and 3 with Raynaud's disease). Only 12 of these patients complained of fatigability and/or myalgia. Electromyography was performed and serum levels of muscle enzymes were measured in all patients. Comparison of thallium 201 exercise recording with the other tests revealed that scan sensitivity is greater than electromyographic and serum muscle enzymes levels. Thallium 201 scans showed abnormal findings in 32 patients and revealed subclinical lesions in 18 patients, while electromyography findings were abnormal in 25 of these 32 patients. Serum enzyme levels were raised in only 8 patients. Thallium 201 scanning proved to be a useful guide for modifying therapy when laboratory data were conflicting. It was useful to evaluate treatment efficacy. Because our data indicate a 100% positive predictive value, we believe that thallium 201 scanning should be advised for severe systemic connective tissue diseases with discordant test results.

  1. REMOVAL OF GLUCORAPHENIN FROM THE EXTRACT OF RADISH PIGMENT BY ANION EXCHANGE RESIN 201×7

    Institute of Scientific and Technical Information of China (English)

    ZhouXiaohua; ChenQi

    1998-01-01

    A method for removimg glucoraphenin from the extract of Radish pigment by anion exchange resin 201×7 was studied.The adsorption capacity of 201×7 resin for glucoraphenin was 72.8mg/ml resin,the equilibrium time 55 minutes,and the optinum pH5.5.All glucoraphenin that had been adsorbed on 201×7 resin was eluted by 1.5BV.hr-1, eluent in whinc concentration of NaOH was 0.05mol·L-1 at the flow rate of 1.5BV/h.Extracting solution of deglucoraphenin was enriched by vacuum and spray drying.A powder product of Radish pigment was obtained and E1cm1%=4.30.

  2. Chest Pain with Normal Thallium-201 Myocardial Perfusion Image – Is It Really Normal?

    Science.gov (United States)

    Liu, Pang-Yen; Lin, Wen-Yu; Lin, Li-Fan; Lin, Chin-Sheng; Lin, Wei-Shiang; Cheng, Shu-Meng; Yang, Shih-Ping; Liou, Jun-Ting

    2016-01-01

    Background Thallium-201 myocardial perfusion image (MPI) is commonly used to detect coronary artery disease in patients with chest pain. Although a normal thallium-201 MPI result is generally considered to be a good prognosis and further coronary angiogram is not recommended, there are still a few patients who suffer from unexpected acute coronary events. The aim of this study was to investigate the clinical prognosis in patients with normal thallium-201 MPI. Methods From January 2006 to August 2012, a total 22,003 patients undergoing thallium-201 MPI in one tertiary center were screened. Of these, 8092 patients had normal results and were investigated retrospectively. During follow-up, 54 patients underwent coronary angiogram because of refractory typical angina pectoris or unexpected acute coronary events. These 54 patients were divided into 2 groups: group I consisted of 26 (48.1%) patients with angiography-proven significant coronary artery stenosis, and group II consisted of 28 (51.9%) patients without significant stenosis. Results Patients in group I had a higher prevalence of prior coronary stenting and electrocardiographic features of ST depression compared with patients in group II. The multivariate analysis demonstrated that both prior coronary stenting and ST depression were risk predictors of unexpected acute coronary events in the patients with normal thallium-201 MPI [odds ratio (OR), 5.93; 95% confidence interval (CI): 1.03-34.06, p = 0.05 and OR, 7.10; 95% CI: 1.28-39.51, p = 0.03,respectively]. Conclusions Although there is a low incidence of unexpected acute coronary events in patients with chest pain and normal thallium-201 MPI, physicians should be aware of the potentials risk in certain patients in this specific population. PMID:27274174

  3. Specific localization of thallium 201 in human high-grade astrocytoma by microautoradiography.

    Science.gov (United States)

    Mountz, J M; Raymond, P A; McKeever, P E; Modell, J G; Hood, T W; Barthel, L K; Stafford-Schuck, K A

    1989-07-15

    The ability to accurately distinguish remaining or recurrent high-grade astrocytoma from necrosis or edema following treatment is essential to optimal patient management. Thallium 201 planar gamma-camera imaging has been shown to be helpful in detecting recurrent high-grade astrocytoma; however, due to tissue heterogeneity adjacent to and within tumor, the cellular specificity and quantification of 201Tl uptake are largely unknown. In order to determine which tissues are responsible for the radioisotope uptake, microautoradiographic techniques were used to examine multiple tissue sections from five patients with high-grade astrocytoma. Each patient received 5 mCi of 201Tl i.v. 1 h prior to tumor removal. Additionally, all patients received computerized tomographic and 201Tl planar gamma-camera scans prior to surgery. Following surgery, the excised tissue specimens were tentatively classified by gross pathological examination and then immediately processed for dry mount autoradiography; grain density was determined over regions containing tumor, adjacent and uninvolved brain tissue, necrotic tissue, and background. Highly significant differences were found in grain densities (201Tl uptake) between tumor and uninvolved brain tissue, as well as between uninvolved brain tissue and necrotic tissue; there was no significant difference between background grain density and that in necrotic tissue. Mean grain densities (grains/cm2 +/- 1 SD) across patients were: tumor, 102 +/- 23; adjacent, uninvolved brain tissue, 29 +/- 11; necrotic tissue, 6.2 +/- 1.1; and background, 7.0 +/- 4.1. We conclude that the ability of 201Tl to selectively image high-grade astrocytoma is due to its preferential uptake into tumor cells.

  4. Studies on Feeding Animals with Straw of Grain-Straw-Dual-Use-Rice 201

    Institute of Scientific and Technical Information of China (English)

    ZHENG Jin-gui; CHEN Jun-chen; HUANG Qin-lou; ZHENG Kai-bin; YE Xin-fu; TU Jie-feng; CHEN Bing-huan

    2002-01-01

    The straw of Grain-Straw-Dual-Use-Rice (GSDUR) variety 201 of which the grain quality and yield were equivalent to that of common rice variety (the grain yield approximately 7.5 t ha-1 ), but straw protein content was 9.31% (common rice straw i.e. CK was approximately 4.0%), and other eight fodder indexes were better than CK to some extent, was employed to feed animals. 15 N tracing result suggested that the protein in 201 straw could be effectively transformed into fish body protein and white mouse body protein. The digestibility of fodder, the 15N recovery rate of animal body and the absorption of fodder protein were 13.8,9.6, 24. 49 % and 16.5, 6.0, 47.2 % higher than those of common rice straw respectively when feeding grass carp and white mice with 201 rice straw, whereas the 1s N recovery rates of animal manure were 3.25, 6.5 %lower than those of common rice straw, respectively. The results of feeding animals with 201 straw were as carp, fish weight gain per kg fresh rice straw were increased by 60.0, 16.8 and 37.0% respectively when 201fresh straw was used to feed grass carp compared to feeding CK, and fish yield could be increased by 297.5 kg creased by 33.9 and 26.8% respectively when 201 rice straw was used as the main raw material of the compound fodder to feed white geese compared to feeding CK, and geese weight could be increased by 2 358.0 kg powder substituting for wheat bran which made up of 5 % compound fodder to feed cross bred pigs compared to CK, but 0. 11 kg fine fodder could be saved when 1 kg cross bred pig weight was increased.

  5. 75 FR 27155 - Delegation of Authority Relating To Certain Functions Under Section 201 (B) of the United States...

    Science.gov (United States)

    2010-05-14

    ... Certain Functions Under Section 201 (B) of the United States- india Nuclear Cooperation Approval And... section 301 of title 3, United States Code, I hereby delegate to you the certification and reporting functions conferred upon the President by section 201 (b) of the United States-India Nuclear...

  6. 49 CFR 173.201 - Non-bulk packagings for liquid hazardous materials in Packing Group I.

    Science.gov (United States)

    2010-10-01

    ... in Packing Group I. 173.201 Section 173.201 Transportation Other Regulations Relating to... materials in Packing Group I. (a) When § 172.101 of this subchapter specifies that a liquid hazardous... of part 173, to the requirements of part 178 of this subchapter at the Packing Group I...

  7. 76 FR 11291 - University of New Mexico AGN-201M Reactor Notice of Issuance of Renewed Facility Operating...

    Science.gov (United States)

    2011-03-01

    ... COMMISSION University of New Mexico AGN-201M Reactor Notice of Issuance of Renewed Facility Operating License... No. R-102, held by the University of New Mexico (the licensee), which authorizes continued operation of the University of New Mexico AGN-201M Reactor (UNMR), located in Albuquerque, Bernalillo...

  8. 40 CFR 201.26 - Procedures for the measurement on receiving property of retarder and car coupling noise.

    Science.gov (United States)

    2010-07-01

    ... receiving property of retarder and car coupling noise. 201.26 Section 201.26 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS NOISE EMISSION STANDARDS FOR TRANSPORTATION... receiving property of retarder and car coupling noise. (a) Retarders—(1) Microphone. The microphone must...

  9. 22 CFR Appendix A to Part 201 - Supplier's Certificate and Agreement With the Agency for International Development (AID 282)

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Supplier's Certificate and Agreement With the Agency for International Development (AID 282) A Appendix A to Part 201 Foreign Relations AGENCY FOR..., App. A Appendix A to Part 201—Supplier's Certificate and Agreement With the Agency for...

  10. Thallium chloride 201Tl combined with single photon emission computed tomography (SPECT) in the evaluation of vestibular schwannoma growth

    DEFF Research Database (Denmark)

    Charabi, Samih Ahmed; Lassen, N A; Thomsen, J;

    1997-01-01

    Thallium chloride 201Tl combined with SPECT was performed in a series of 29 patients with neuroradiological evidence of vestibular schwannoma (VS). The relative tumor uptake (U) and relative tumor concentration (C) of the radiotracer 201Tl was determined, and the cerebellum served as a reference....

  11. 31 CFR 597.201 - Prohibited transactions involving blocked assets or funds of foreign terrorist organizations or...

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Prohibited transactions involving blocked assets or funds of foreign terrorist organizations or their agents. 597.201 Section 597.201 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

  12. 47 CFR 95.201 - (R/C Rule 1) What is the Radio Control (R/C) Radio Service?

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false (R/C Rule 1) What is the Radio Control (R/C) Radio Service? 95.201 Section 95.201 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Radio Control (R/C) Radio Service...

  13. 9 CFR 201.49 - Requirements regarding scale tickets evidencing weighing of livestock, live poultry, and feed.

    Science.gov (United States)

    2010-01-01

    ... evidencing weighing of livestock, live poultry, and feed. 201.49 Section 201.49 Animals and Animal Products... regarding scale tickets evidencing weighing of livestock, live poultry, and feed. (a) Livestock. When... the weigher. (b) Poultry. When live poultry is weighed for the purpose of purchase, sale,...

  14. 21 CFR 201.26 - Exceptions or alternatives to labeling requirements for human drug products held by the Strategic...

    Science.gov (United States)

    2010-04-01

    ... requirements for human drug products held by the Strategic National Stockpile. 201.26 Section 201.26 Food and... drug products held by the Strategic National Stockpile. (a) The appropriate FDA Center Director may... lots, batches, or other units of a human drug product that are or will be held in the...

  15. 13 CFR 123.201 - When am I not eligible to apply for a physical disaster business loan?

    Science.gov (United States)

    2010-01-01

    ... business in the business area; (6) Your implementation of decisions adopted and at least partially... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When am I not eligible to apply for a physical disaster business loan? 123.201 Section 123.201 Business Credit and Assistance...

  16. Comparison of thallium-201 scan and Tc-99m sestamibi scan in the differential diagnosis of breast mass

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Ihn Ho; Won, Kyu Jang; Lee, Hyung Woo; Lee, Soon Jung [College of Medicine, Yonsei Univ., Seoul (Korea, Republic of)

    1999-02-01

    We performed this study to compare Tl-201 and Tc-99m MIBI scans for the differentiation of malignant from benign breast mass. Thirty-eight female patients underwent Tl-201 breast scan and thirty-two of them also underwent Tc-99m MIBI scan of the breast. After intravenous injection of 74-111 MBq of Tl-201, early (10 minutes) and delayed (3 hours) images were obtained. Then, 555-740 MBq of Tc-99m MIBI was injected and images after 30 minutes were obtained. We compared Tl-201 and Tc-99m MIBI scans with pathologic results. Twenty-three patients were confirmed to have infiltrating duct carcinoma and fifteen patients to have benign breast mass by excisonal biopsy. The sensitivity of early and delayed Tl-201 scan and Tc-99m MIBI scan in the detection of malignant breast lesion were 100% (23/23), 82% (18/22), and 90% (18/20), respectively. The sensitivity of early Tl-201 scan was significantly higher than that of delayed Tl-201 scan, (p<0.05). The specificity of early and delayed Tl-201 scan and Tc-99m MIBI scan were 73% (11/15), 73% (11/15) and 83% (10/12), respectively (p: not significant). Three patients out of nine with fibroadenoma and one patient with atypical duct hyperplasia were false positive in both early and delayed Tl-201 scans. The size of fibroadenoma with false positive in early and delayed Tl-201 scan (4 cases) was larger than that of 11 fibroadenoma with true negative scan (p<0.01). Metastatic axillary lymph node involvement was present in fifteen patients. The sensitivity to detect metastatic nodes was 38% (5/13) for early Tl-201 images, 15% (2/13) for delayed Tl-201 images, 58% (7/12) for Tc-99m MIBI planar images and 67% (4/6) for Tc-99m MIBI SPECT. The sensitivity of Tc-99m MIBI planar or SPECT was significantly higher than that of delayed Tl-201 images (p<0.05). Early Tl-201 and Tc-99m MIBI scan are useful noninvasive methods to differentiate malignant from benign mass of breast. Tc-99m MIBI scan was sensitive in detecting axillary lymph node

  17. Tolerância da cultivar de soja coodetec 201 aos herbicidas inibidores de als Tolerance of the soybean cultivar Coodetec 201 to ALS inhibitor herbicides

    Directory of Open Access Journals (Sweden)

    Aldo Merotto Jr

    2000-01-01

    Full Text Available A obtenção de cultivares resistentes aos herbicidas possibilita o aumento da diversidade dos herbicidas utilizados seletivamente para o controle de plantas daninhas em uma determinada cultura. O aumento da disponibilidade destes herbicidas na cultura da soja pode proporcionar maior facilidade no controle de plantas daninhas de difícil eliminação, de espécies com características biológicas semelhantes à cultura e de plantas daninhas resistentes aos herbicidas. O objetivo deste trabalho foi avaliar a resistência cruzada da cultivar COODETEC 201 a três herbicidas inibidores da ALS, não seletivos para a cultura da soja. O experimento foi realizado em casa de vegetação através da semeadura em vasos, o qual foi disposto em delineamento completamente casualizado em arranjo fatorial. Os tratamentos constaram das cultivares de soja COODETEC 201 e OCEPAR 14 e dos herbicidas imazapyr, metsulfuron e nicosulfuron, aplicados em cinco doses. A aplicação destes produtos foi realizada 30 dias após a emergência, quando as plantas de soja estavam no estádio V4. A área foliar e a fitoxicidade aos 14 e 35 dias após a aplicação do herbicida metsulfuron foram menos afetadas na cultivar COODETEC 201 do que na OCEPAR 14. A determinação da restrição do crescimento das plantas em função da matéria seca das plantas demonstrou que as duas cultivares são igualmente sensíveis ao herbicida imazapyr. A cultivar COODETEC 201 apresentou maior tolerância aos herbicidas metsulfuron e nicosulfuron, sendo 10,25 e 3,25 vezes, respectivamente, mais resistente do que a cultivar OCEPAR 14.Herbicide resistant crops can increase the availability of herbicides for selective use in soybean, can provide weed control of tolerant weed species, weed with identical biological characteristics to the crop, and resitant weeds to herbicides. The objective of this research was to evaluate the cross resitance in the soybean cultivar Coodetec 201 to three ALS inhibitor

  18. INGN 201: Ad-p53, Ad5CMV-p53, Adenoviral p53, INGN 101, p53 gene therapy--Introgen, RPR/INGN 201.

    Science.gov (United States)

    2003-01-01

    Introgen's adenoviral p53 gene therapy [INGN 201, ADVEXIN] is in clinical development for the treatment of various cancers. The p53 tumour suppressor gene is deleted or mutated in many tumour cells and is one of the most frequently mutated genes in human tumours. INGN 201 has been shown to kill cancer cells directly. In August 2002, Introgen announced plans to file an application for INGN 201 with the European Agency for the Evaluation of Medicinal Products (EMEA) for the treatment of head and neck cancer; the European filing will be submitted simultaneously with the previously scheduled (planned for 2004) submission of a Biologics License Application (BLA) for ADVEXIN to the US FDA. On 20 February 2003, INGN 201 received orphan drug designation from the US FDA for head and neck cancer. INGN 201 is available for licensing although Introgen favours retaining partial or full rights to the therapy in the US. Introgen Therapeutics and its collaborative partner for the p53 programme, Aventis Gencell, have been developing p53 gene therapy products. The agreement was originally signed by Rhône-Poulenc Rorer's Gencell division, which became Aventis Gencell after Rhône-Poulenc Rorer merged with Hoechst Marion Roussel to form Aventis Pharma. According to the original agreement, Introgen was responsible for phase I and preclinical development in North America, while Aventis Gencell was responsible for clinical trials conducted in Europe and for clinical trials in North America beyond phase I. In April 2001, Aventis Gencell and Introgen restructured their existing collaboration agreement for p53 gene therapy products. Aventis Gencell indicated that p53 research had suffered from internal competition for resources and was pulling back from its development agreement with Introgen for p53 gene therapy products. Introgen will assume responsibility for worldwide development of all p53 programmes and will obtain exclusive worldwide commercial rights to p53-based gene therapy

  19. 30 CFR 250.201 - What plans and information must I submit before I conduct any activities on my lease or unit?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What plans and information must I submit before I conduct any activities on my lease or unit? 250.201 Section 250.201 Mineral Resources MINERALS... CONTINENTAL SHELF Plans and Information General Information § 250.201 What plans and information must I...

  20. 76 FR 59157 - Public Land Order No. 7783; Extension of Withdrawal Created by Subtitle A of Public Law 104-201; CO

    Science.gov (United States)

    2011-09-23

    ... Public Law 104-201; CO AGENCY: Bureau of Land Management, Interior. ACTION: Public Land Order. SUMMARY: This order extends the duration of a withdrawal created by Subtitle A of Public Law 104-201 for an additional 15-year period. Subtitle A of Public Law 104-201 withdrew 3,133 acres of public lands and...

  1. INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201.

    Science.gov (United States)

    2007-01-01

    Introgen and its wholly owned European subsidiary Gendux AB are developing an adenoviral p53 gene therapy as a treatment for cancer in the US and Europe, respectively. Phase III trials in patients with head and neck cancer are ongoing, and a number of clinical trials in other cancer indications have been completed. INGN 201 is being reviewed by the EMEA for approval in Li-Fraumeni syndrome (LFS) under the provisions of exceptional circumstance; the therapy is available on a compassionate use basis to eligible LFS cancer patients under a protocol authorised by the US FDA. The p53 tumour suppressor gene is deleted or mutated in many tumour cells and is one of the most frequently mutated genes in human tumours. The p53 protein is one of the most intricate elements in the apoptotic signalling cascade, and a mutation in the gene encoding it is believed to result in a decreased ability of a cell to apoptose. Thus replacing this gene via adenovirally-mediated p53 gene therapy is hoped to result in increased apoptosis where it is administered.INGN 201 is available for licensing, although Introgen favours retaining partial or full rights to the therapy in the US. Introgen entered into a license agreement with The University of Texas System and MD Anderson Cancer Center in 1994. The technologies licenced include p53 and fus1 (INGN 401). The collaboration has yielded exclusive patent and licensing rights to numerous technologies. Introgen entered into a collaboration with Rhône-Poulenc Rorer Pharmaceuticals (now sanofi-aventis) to develop therapeutics based on p53 inhibition in October 1994. However, in June 2001 this relationship was restructured and Introgen assumed responsibility for the worldwide development of all p53 products including INGN 201, and acquired all marketing and commercialisation rights with respect to those products. Introgen initiated two phase III trials in head and neck cancer (in June 2000 and May 2001) at about 80 sites in the US, Canada and Europe

  2. LDEF (Prelaunch), AO201 : Interplanetary Dust Experiment, Tray B12

    Science.gov (United States)

    1984-01-01

    LDEF (Prelaunch), AO201 : Interplanetary Dust Experiment, Tray B12 The prelaunch photograph shows the six (6) inch deep Interplanetary Dust Experiment (IDE) master control tray. The tray has three (3) mounting/cover plates elevated on fiberglass stand-offs to provide clearance and protection for hardware and electronics located underneath. The stand-offs also raise the plates to a level that minimizes shading of detectors by the tray sidewalls. The mounting plate located at the left hand end of the tray is populated with eighty (80) metaloxide-silicon (MOS) capacitor-type impact sensors and one (1) solar sensor that is located approximately in the center of the mounting plate. The IDE sensors are two (2) inch diameter MOS capacitor structures approximately 250 um thick. The detectors are formed by growing either 0.4um or 1.0um thick silicon oxide, SiO2, layer on the 250um thick, B-doped polished silicon wafer. The top metal contact, the visible surface, was formed by vapor deposition of 1000A of aluminum on the SiO2 surface. Aluminum was also vapor deposited on the backside to form the contact with the silicon substrate. Gold wires are bonded to the front and back aluminum layers for use in connecting the detectors to the circuits. The complete wafers, IDE detectors, are mounted on chromic anodized aluminum frames by bonding the detector backside to the aluminum frame with a space qualified RTV silicon adhesive, de-volatized RTV-511. The difference in colors of the detectors is caused by reflections in the metallized surfaces. A reflection of one of the technicians is visible in the three (3) rows of detector on the left hand side of the mounting plate. The solar sensor, located at the mounting plate center, consist of four (4) silicon solar cells connected in series and associated circuity bonded to an aluminum baseplate. The solar sensor registered each orbital sunrise independant of LDEF orientation at the time of sunrise. When IDE solar sensor data from the six

  3. 48 CFR 31.201-7 - Construction and architect-engineer contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Construction and architect... Organizations 31.201-7 Construction and architect-engineer contracts. Specific principles and procedures for... architect-engineer contracts related to construction projects, are in 31.105. The applicability of...

  4. 37 CFR 201.8 - Disruption of postal or other transportation or communication services.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Disruption of postal or other... OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES GENERAL PROVISIONS § 201.8 Disruption of... Register has determined that there is or has been a general disruption or suspension of postal or...

  5. 7 CFR 201.51a - Special procedures for purity analysis.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Special procedures for purity analysis. 201.51a... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Purity Analysis in the Administration of the Act §...

  6. Quantitative assessment of regional myocardial blood flow with thallium-201 and SPECT.

    Science.gov (United States)

    Iida, H; Eberl, S

    1998-01-01

    Thallium-201 has been used extensively as a myocardial perfusion agent and to assess myocardial viability. Unlike other 99mTc-labeled agents such as 99mTc-sestamibi and 99mTc-tetrofosmine, the regional concentration of 201Tl varies with time, and its kinetics make it a potential candidate for estimating absolute physiologic parameters with kinetic model analysis. This article outlines a strategy for quantitative assessment of regional myocardial blood flow in man using 201Tl and dynamic single photon emission computed tomography (SPECT). Quantitatively accurate SPECT images that are proportional to the true radioactivity distribution are prerequisites for model-based kinetic analysis. Our technique for quantitative SPECT includes ordered-subset maximum likelihood-expectation maximization (ML-EM) reconstruction with transmission data-based attenuation correction and transmission-dependent convolution subtraction scatter correction. A three-compartment model was found to reproduce the observed regional time-activity curves well, and dog experiments demonstrated that influx rate constant (K1) values estimated from the dynamic SPECT data correlated well with absolute myocardial blood flow determined by in vitro microspheres for a physiologically wide range of flows. Several possible strategies for simplifying the study procedures, without compromising accuracy, are also presented, which should make absolute quantitation of regional myocardial blood flow feasible using 201Tl and a conventional SPECT camera in a clinical setting.

  7. 42 CFR 1001.201 - Conviction relating to program or health care fraud.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Conviction relating to program or health care fraud... Permissive Exclusions § 1001.201 Conviction relating to program or health care fraud. (a) Circumstance for... misdemeanor relating to fraud, theft, embezzlement, breach of fiduciary responsibility, or other...

  8. Investigating Validity of Math 105 as Prerequisite to Math 201 among Undergraduate Students, Nigeria

    Science.gov (United States)

    Zakariya, Yusuf F.

    2016-01-01

    In this study, the author examined the validity of MATH 105 as a prerequisite to MATH 201. The data for this study was extracted directly from the examination results logic of the university. Descriptive statistics in form of correlations and linear regressions were used to analyze the obtained data. Three research questions were formulated and…

  9. 76 FR 12712 - Announcing Draft Federal Information Processing Standard (FIPS) 201-2, Personal Identity...

    Science.gov (United States)

    2011-03-08

    ... once every twelve years, to update files to account for normal aging. Subsequent to the issuance of..., removal of conflicting requirements, additional text to improve clarity, adaptation to changes in the environment since the publication of FIPS 201-1, and specific changes requested by Federal agencies...

  10. 31 CFR 560.803 - Customs procedures: Goods specified in § 560.201.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Customs procedures: Goods specified... REGULATIONS Procedures § 560.803 Customs procedures: Goods specified in § 560.201. (a) With respect to goods... Customs officers shall not accept or allow any: (1) Entry for consumption or warehouse (including...

  11. 45 CFR 46.201 - To what do these regulations apply?

    Science.gov (United States)

    2010-10-01

    ... HUMAN SUBJECTS Additional Protections for Pregnant Women, Human Fetuses and Neonates Involved in Research § 46.201 To what do these regulations apply? (a) Except as provided in paragraph (b) of this section, this subpart applies to all research involving pregnant women, human fetuses, neonates...

  12. 5 CFR 2634.201 - General requirements, filing dates, and extensions.

    Science.gov (United States)

    2010-01-01

    ... EXECUTIVE BRANCH FINANCIAL DISCLOSURE, QUALIFIED TRUSTS, AND CERTIFICATES OF DIVESTITURE Persons Required To File Public Financial Disclosure Reports § 2634.201 General requirements, filing dates, and extensions... days shall file a public financial disclosure report containing the information prescribed in subpart...

  13. 7 CFR 767.201 - Real estate inventory property with important resources.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Real estate inventory property with important... SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS INVENTORY PROPERTY MANAGEMENT Real Estate Property With Important Resources or Located in Special Hazard Areas § 767.201 Real estate...

  14. 22 CFR 201.46 - Compensation to supplier if shipment is prohibited.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Compensation to supplier if shipment is... Commodities and Commodity-Related Services § 201.46 Compensation to supplier if shipment is prohibited. (a) Payment to supplier. USAID shall make appropriate payment to a supplier for the value of...

  15. 11 CFR 201.3 - Public funding, audits and litigation: Ex parte contacts prohibited.

    Science.gov (United States)

    2010-01-01

    ... soon after the communication as is reasonably possible but no later than three business days after the... communication as is reasonably possible but no later than three business days after the communication, unless... REGULATIONS EX PARTE COMMUNICATIONS § 201.3 Public funding, audits and litigation: Ex parte...

  16. 12 CFR 201.110 - Goods held by persons employed by owner.

    Science.gov (United States)

    2010-01-01

    ... not comply with the requirement of section 13 of the Federal Reserve Act that a banker's acceptance be... requirements of section 13 of the Federal Reserve Act. Moreover, in a properly conducted field warehousing....110 Section 201.110 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL...

  17. 24 CFR 115.201 - The two phases of substantial equivalency certification.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false The two phases of substantial... ENFORCEMENT AGENCIES Certification of Substantially Equivalent Agencies § 115.201 The two phases of.... The Department has developed a two-phase process of substantial equivalency certification....

  18. Evaluation of left ventricular eccentric hypertrophy by /sup 201/Tl-myocardial scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Yamazaki, Junichi; Kawamura, Yasuaki; Okuzumi, Ichio; Morishita, Takeshi; Koyama, Nobuya; Komatsu, Hisashi; Ohsawa, Hidefumi; Yabe, Yoshimasa

    1989-03-01

    In order to elucidate the mechanism of left ventricular eccentric hypertrophy in conditions of volume overload, Tl-201 myocardial scintigraphy was performed in patients with aortic valve regurgitation and mitral valve regurgitation. There was a good relationship between the severity of Tl-defects, as determined by Tl-201 myocardial scintigraphy, and the changes in the T wave on the ECG on the one hand and the NYHA functional classification of heart diseases. In 17 of 18 patients where LVDd increased with increasing severity of Tl-defects and the defects were moderate to severe, LVDd was 65 mm or larger. There was a significant negative correlation between the washout rate for the whole circumference of the left ventricle, as determined by exercise Tl-201 SPECT, and LVDd (r=-0.603, p<0.01). The phenomenon of redistribution as determined by exercise Tl-201 myocardial scintigraphy was observed relatively early. Our results suggest that mechanical volume overload and ischemic changes are involved in left ventricular wall damage in left ventricular eccentric hypertrophy. For patients with moderate to severe Tl-defects valve replacement is indicated, no matter whether they may have heart failure or arrhythmia.

  19. 47 CFR 13.201 - Qualifying for a commercial operator license or endorsement.

    Science.gov (United States)

    2010-10-01

    ... RADIO OPERATORS Examination System § 13.201 Qualifying for a commercial operator license or endorsement. (a) To be qualified to hold any commercial radio operator license, an applicant must have a... commercial radio operator license, other than the Restricted Radiotelephone Operator Permit and...

  20. 17 CFR 201.326 - Evidence: Presentation, rebuttal and cross-examination.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Evidence: Presentation... EXCHANGE COMMISSION RULES OF PRACTICE Rules of Practice Rules Regarding Hearings § 201.326 Evidence: Presentation, rebuttal and cross-examination. In any proceeding in which a hearing is required to be...

  1. 9 CFR 201.67 - Packers not to own or finance selling agencies.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Packers not to own or finance selling... STOCKYARDS ACT Trade Practices § 201.67 Packers not to own or finance selling agencies. No packer subject to the Act shall have an ownership interest in, finance, or participate in the management or operation...

  2. 7 CFR 201.33 - Seed in bulk or large quantities; seed for cleaning or processing.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Seed in bulk or large quantities; seed for cleaning or... (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling in General § 201.33 Seed in bulk or large quantities; seed for cleaning or processing. (a) In the case of seed in bulk, the information required...

  3. 7 CFR 201.55a - Moisture and aeration of substratum.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Moisture and aeration of substratum. 201.55a Section... and aeration of substratum. (a) The substratum must be moist enough to supply the needed moisture to the seeds at all times. Excessive moisture which will restrict aeration of the seeds should be...

  4. 21 CFR 201.19 - Drugs; use of term “infant”.

    Science.gov (United States)

    2010-04-01

    ...: GENERAL LABELING General Labeling Provisions § 201.19 Drugs; use of term “infant”. The regulations affecting special dietary foods (§ 105.3(e) of this chapter) define an infant as a child not more than 12... term infant. Some question has arisen whether, for the purposes of drug labeling, an infant means...

  5. 37 CFR 201.11 - Satellite carrier statements of account covering statutory licenses for secondary transmissions.

    Science.gov (United States)

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Satellite carrier statements... PROVISIONS § 201.11 Satellite carrier statements of account covering statutory licenses for secondary... royalty fees in the Copyright Office as required by the satellite carrier license of section 119(b)(1)...

  6. 9 CFR 201.108-1 - Instructions for weighing live poultry.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Instructions for weighing live poultry... STOCKYARDS ACT Poultry-Packers and Live Poultry Dealers § 201.108-1 Instructions for weighing live poultry. Live poultry dealers who operate scales on which live poultry is weighed for purposes of purchase,...

  7. [Corrosion of stainless steel 201, 304 and 316L in the simulated sewage pipes reactor].

    Science.gov (United States)

    Bao, Guo-Dong; Zuo, Jian-E; Wang, Ya-Jiao; Gan, Li-Li

    2014-08-01

    The corrosion behavior of stainless steel 201, 304 and 316L which would be used as sewer in-situ rehabilitation materials was studied in the simulated sewage pipes reactor. The corrosion potential and corrosion rate of these three materials were studied by potentiodynamic method on the 7th, 14th, 21st, 56th day under two different conditions which were full immersion condition or batch immersion condition with a 2-day cycle. The electrode process was studied by Electrochemical Impedance Spectroscopy (EIS) on the 56th day. The microstructure and composition of the corrosion pitting were analyzed by Scanning Electron Microscope (SEM) and Energy Dispersive Spectrometer (EDS) on the 56th day. The results showed that 304 and 316L had much better corrosion resistance than 201 under both conditions. 304 and 316L had much smaller corrosion rate than 201 under both conditions. The corrosion resistance of all three kinds of stainless steel under the batch immersion condition was much better than those under the full immersion condition. The corrosion rate of all three kinds of stainless steel under the batch immersion condition was much smaller than those under the full immersion condition. Point pitting corrosion was formed on the surfaces of 304 and 316L. In comparison, a large area of corrosion was formed in the surface of 201.

  8. 49 CFR 172.201 - Preparation and retention of shipping papers.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Preparation and retention of shipping papers. 172..., TRAINING REQUIREMENTS, AND SECURITY PLANS Shipping Papers § 172.201 Preparation and retention of shipping papers. (a) Contents. When a description of hazardous material is required to be included on a...

  9. 7 CFR 205.201 - Organic production and handling system plan.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Organic production and handling system plan. 205.201... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL ORGANIC PROGRAM Organic Production and...

  10. 49 CFR 192.201 - Required capacity of pressure relieving and limiting stations.

    Science.gov (United States)

    2010-10-01

    ... Design of Pipeline Components § 192.201 Required capacity of pressure relieving and limiting stations. (a) Each pressure relief station or pressure limiting station or group of those stations installed to... 49 Transportation 3 2010-10-01 2010-10-01 false Required capacity of pressure relieving...

  11. 4 CFR 201.11 - Requirements for waiver or reduction of fees.

    Science.gov (United States)

    2010-01-01

    ... Section 201.11 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PUBLIC INFORMATION AND REQUESTS... request additional information if necessary. However, the Board must make a determination on the fee... information. In certain circumstances, a partial fee waiver may be appropriate, if some, but not all, of...

  12. 24 CFR 201.28 - Flood and hazard insurance, and Coastal Barriers properties.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Flood and hazard insurance, and... Disbursement Requirements § 201.28 Flood and hazard insurance, and Coastal Barriers properties. (a) Flood... part if the property securing repayment of the loan is located in a special flood hazard...

  13. 49 CFR 179.201-5 - Postweld heat treatment and corrosion resistance.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Postweld heat treatment and corrosion resistance....201-5 Postweld heat treatment and corrosion resistance. (a) Tanks and attachments welded directly... tested to demonstrate that they possess the corrosion resistance specified in § 179.200-7(d), Footnote...

  14. 9 CFR 201.86 - Brand inspection: Application for authorization, registration and filing of schedules, reciprocal...

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Brand inspection: Application for... STOCKYARDS ACT Inspection of Brands § 201.86 Brand inspection: Application for authorization, registration... statute, which desires to obtain an authorization to charge and collect a fee for the inspection of...

  15. 37 CFR 201.28 - Statements of Account for digital audio recording devices or media.

    Science.gov (United States)

    2010-07-01

    ... COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES GENERAL PROVISIONS § 201.28 Statements... required under 17 U.S.C. 1003, to be filed no later than two months after the close of the accounting... importing party to perform the annual audit of the party's financial statement. (8) Quarterly statement...

  16. 47 CFR 68.201 - Connection to the public switched telephone network.

    Science.gov (United States)

    2010-10-01

    ... CARRIER SERVICES (CONTINUED) CONNECTION OF TERMINAL EQUIPMENT TO THE TELEPHONE NETWORK Terminal Equipment Approval Procedures § 68.201 Connection to the public switched telephone network. Terminal equipment may not be connected to the public switched telephone network unless it has either been certified by...

  17. 46 CFR 11.201 - Eligibility for officer endorsements and STCW endorsements, general.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Eligibility for officer endorsements and STCW... Endorsements § 11.201 Eligibility for officer endorsements and STCW endorsements, general. (a) In addition to... original officer's endorsement, raises of grade, extensions of route, or STCW endorsements must be...

  18. MRI and thallium-201 SPECT in the prediction of survival in glioma

    Energy Technology Data Exchange (ETDEWEB)

    Vos, Maaike J. [VU University Medical Center, Department of Neurology, Amsterdam (Netherlands); Medical Center Haaglanden, Department of Neurology, PO Box 432, The Hague (Netherlands); Berkhof, Johannes [VU University Medical Center, Department of Epidemiology and Biostatistics, Amsterdam (Netherlands); Hoekstra, Otto S. [VU University Medical Center, Department of Nuclear Medicine and PET Research, Amsterdam (Netherlands); Bosma, Ingeborg; Sizoo, Eefje M.; Heimans, Jan J.; Reijneveld, Jaap C.; Postma, Tjeerd J. [VU University Medical Center, Department of Neurology, Amsterdam (Netherlands); Sanchez, Esther [VU University Medical Center, Department of Radiology, Amsterdam (Netherlands); Lagerwaard, Frank J. [VU University Medical Center, Department of Radiation Oncology, Amsterdam (Netherlands); Buter, Jan [VU University Medical Center, Department of Medical Oncology, Amsterdam (Netherlands); Noske, David P. [VU University Medical Center, Department of Neurosurgery and Neuro-Oncology Research Group, Amsterdam (Netherlands)

    2012-06-15

    This paper aims to study the value of MRI and Thallium 201 ({sup 201}Tl) single-photon emission computed tomography (SPECT) in the prediction of overall survival (OS) in glioma patients treated with temozolomide (TMZ) and to evaluate timing of radiological follow-up. We included patients treated with TMZ chemoradiotherapy for newly diagnosed glioblastoma multiforme (GBM) and with TMZ for recurrent glioma. MRIs and {sup 201}Tl SPECTs were obtained at regular intervals. The value of both imaging modalities in predicting OS was examined using Cox regression analyses. Altogether, 138 MRIs and 113 {sup 201}Tl SPECTs in 46 patients were performed. Both imaging modalities were strongly related to OS (P {<=} 0.02). In newly diagnosed GBM patients, the last follow-up MRI (i.e., after six adjuvant TMZ courses) and SPECT (i.e., after three adjuvant TMZ courses) were the strongest predictors of OS (P = 0.01). In recurrent glioma patients, baseline measurements appeared to be the most predictive of OS (P < 0.01). The addition of one imaging modality to the other did not contribute to the prediction of OS. Both MRI and {sup 201}Tl SPECT are valuable in the prediction of OS. It is adequate to restrict to one of both modalities in the radiological follow-up during treatment. In the primary GBM setting, MRI after six adjuvant TMZ courses contributes significantly to the prediction of survival. In the recurrent glioma setting, baseline MRI appears to be a powerful predictor of survival, whereas follow-up MRIs during TMZ seem to be of little additional value. (orig.)

  19. Right ventricular visualization by Tl-201 myocardial scintigraphy in chronic obstructive pulmonary disease

    Energy Technology Data Exchange (ETDEWEB)

    Fujii, Tadashige; Tanaka, Masao; Takeda, Masashi; Matsuzawa, Yukinori; Handa, Kenjiro; Yoshimura, Kazuhiko (Shinshu Univ., Matsumoto, Nagano (Japan). Faculty of Medicine)

    1993-04-01

    Tl-201 myocardial scintigraphy was performed in 130 patients with chronic obstructive pulmonary disease (COPD) to evaluate right ventricular hypertrophy, and the clinical significance of this method was studied. Tl-201 uptake ratios of the right ventricle, which represents the ratio of total counts of the right ventricle to counts of the administered dose of Tl-201, was higher in COPD, especially in pulmonary emphysema and B type COPD by Burrows classification than in controls. The grade of visualization of the right ventricle by visual assessment (RVV) was marked (+++) in only a few cases and moderate (++) in many cases (more than 80%) in all diseases except bronchial asthma. The incidence of right ventricular hypertrophy by electrocardiogram, right-sided heart failure and marked dyspnea (Hugh-Jones 4[center dot]5) were very low in cases with RVV grade ++ and very high in cases with +++. The grade of RVV was related to the severity of pulmonary perfusion impairment, although in diffuse panbronchiolitis the RVV was relatively slight compared with the impairment of perfusion. May parameters of pulmonary function such as %VC, FEV1.0%, RV/TLC, V25, %DLCO, Raw, [Delta]N[sub 2] and PaO[sub 2] showed abnormal values in patients with RVV grade of (++) or (+++) in all diseases except bronchial asthma. In COPD, Tl-201 myocardial scintigraphy seems to be useful for assessment of right ventricular overloading, and for follow-up observation and differentiation between cor pulmonale and right ventricular hypertrophy secondary to cardiac diseases by observing Tl-201 uptake of the lung and left ventricle. (author).

  20. Prevalence and correlates of increased lung/heart ratio of thallium-201 during dipyridamole stress imaging for suspected coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Villanueva, F.S.; Kaul, S.; Smith, W.H.; Watson, D.D.; Varma, S.K.; Beller, G.A. (Univ. of Virginia School of Medicine, Charlottesville (USA))

    1990-12-01

    There is little information concerning the prevalence and clinical correlates of increased pulmonary thallium-201 uptake during dipyridamole thallium-201 stress imaging. Accordingly, the clinical characteristics and quantitative thallium-201 findings were correlated with quantitative lung/heart thallium-201 ratio in 87 patients undergoing dipyridamole thallium-201 stress testing. Nineteen patients (22%) had an elevated ratio (greater than 0.51). These patients were more likely to have had an infarction, to be taking beta blockers, and have a lower rate-pressure product after dipyridamole administration than those with a normal ratio (p less than 0.03). An elevated ratio was associated with a greater likelihood of initial, redistribution and persistent defects, as well as left ventricular cavity dilatation on thallium-201 imaging (p less than 0.05). In addition, the number of myocardial segments demonstrating initial, redistribution and persistent defects was also greater in patients with increased ratios (p less than 0.03). Multivariate analysis demonstrated that the presence of redistribution and left ventricular cavity dilatation were the most significant correlates of lung/heart thallium-201 ratio. It is concluded that the prevalence of increased lung/heart thallium-201 ratio with dipyridamole thallium-201 stress imaging is similar to that seen with exercise stress imaging. As with exercise thallium-201 imaging, increased pulmonary thallium-201 uptake may be a marker of functionally more significant coronary artery disease.

  1. {sup 201}Tl scintigraphy in the evaluation of palpable and nonpalpable breast lesions: correlation with mammography and ultrasonography

    Energy Technology Data Exchange (ETDEWEB)

    Vural, G.; Atasever, T.; Oezdemir, A.; Oeznur, I.; Karabacak, N.I.; Goekcora, N.; Isik, S. [Gazi Univ., Dept. of Nuclear Medicine, Ankara (Turkey)]|[Gazi Univ., Dept. of Radiology, Ankara (Turkey); Uenlue, M. [Gazi Univ., Dept. of Nuclear Medicine, Ankara (Turkey)

    1997-12-01

    Tl-201 scintigraphy were performed in sixty-eight patients with 70 breast abnormalities (51 palpable, 19 nonpalpable) and compared with mammography and ultrasonography (US). Early (15 min) and late (3 h) images of the breasts were obtained following the injection of 111 MBq (3 mCi) of Tl-201. Visual and semiquantitative interpretation was performed. Final diagnosis confirmed 52 malignant breast lesions and 18 benign conditions. Tl-201 visualized 47 of 52 (90%) overall malignant lesions. Thirty-eight of 40 (95%) palpable and 9 of 12 (75%) nonpalpable breast cancers were detected by Tl-201 scintigraphy. The smallest mass lesion detected by Tl-201 measured 1.5x1.0 cm. Eleven breast lesions were interpreted as indeterminate by mammography and/or sonography. Tl-201 scintigraphy excluded malignancy in 7 of 8 (88%) patients with benign breast lesions interpreted as indeterminate. Five of the 18 (28%) benign breast lesions showed Tl-201 uptake. None of the fibroadenoma and fibrocystic changes accumulated Tl-201. Tl-201 scintigraphy, mammography and ultrasonography showed 90%, 92%, 85% overall sensitivity and 72%, 56%, 61% overall specificity respectively. Twenty-one of the 28 (75%) axillary nodal metastatic sites were also detected by Tl-201. In malignant and benign lesions, early and late lesion/contralateral normal side (L/N) ratios were 1.58{+-}0.38 (mean{+-}SD) and 1.48{+-}0.32 (p>0.05), 1.87{+-}0.65 and 1.34{+-}0.20 (p<0.5) respectively. The mean early and late L/N ratios of malignant and benign groups did not show statistical difference (p>0.05). (orig./MG) [Deutsch] 68 Patientinnen mit insgesamt 70 Laesionen (davon 51 palpable Tumoren) wurden untersucht: 15 Min. und 3 Std. nach Injektion von 111 MBq (3 mCi) {sup 201}Tl-Cl wurden planare Aufnahmen von ventral, lateral und schraeg-lateral durchgefuehrt. Die Auswertung erfolgte sowohl visuel-qualitativ als auch semiquantitativ. Von 52 Karzinomen wurden durch die {sup 201}Tl-Szintigraphie 47 (90%) richtig erkannt

  2. The mathematical model for ID-201 semiconductor single photon counter%ID-201单光子计数器计数模型研究

    Institute of Scientific and Technical Information of China (English)

    曹攀; 朱广浩; 金飚兵

    2016-01-01

    InGaAs半导体单光子探测器具备探测性能强,集成度高等优势,在光谱分析和量子通信等领域有广泛的应用.本文以ID Quantique公司出品的ID-201半导体单光子计数器为研究对象,结合计数器核心部件雪崩光电二极管的工作原理探究其计数光子时的内部过程,推导出每秒钟光子计数值和该计数器几个重要参数触发频率(trigger frequency),门脉冲宽度(gate width),门强制关闭时间(dead time),探测效率(detection efficiency)之间的数学表达式.推导过程着重分析了计数门脉冲的关闭效应对光子探测概率的影响.首先利用泊松分布求解光子计数值与探测效率(detection efficiency)之间的关系,然后将计数过程分成两大部分,分析计数结果与门强制关闭时间(dead time)之间关系.求解得表达式后,利用1550 nm激光器作为ID-201的输入光源,在各种不同实验条件下,对该表达式的正确性进行了检验.%The technology of photon counting has wide applications in physics and electrical engineering.Single photon detectors based on avalanche photodiodes are attractive,Considering their advantages including compact sizes,broad spectrum of responses,and high detection efficiencies.The semiconductor single photon detector normally works in the gated mode,where photons can only be detected when the gate is open.However,if any photon is detected by the photon counter during the gate,several gates after the detection will be forced to shut down so that no photon can be detected during this period.The timing duration that the gates are down is called the dead time.This article mainly focuses on the photon counting performance of the ID-201 semiconductor photon counter,which is produced by the ID Quantique company.The purpose is to derive a photon counting formula for ID-201 and verify it using experiments.Starting with a simple Poisson distribution,we first studied the relationship between the detection

  3. Dose response of sodium nitrite on vasoactivity associated with HBOC-201 in a swine model of controlled hemorrhage.

    Science.gov (United States)

    Arnaud, Françoise; Scultetus, Anke H; Kim, Bobby; Haque, Ashraful; Saha, Biswajit; Nigam, Savita; Moon-Massat, Paula; Auker, Charles; McCarron, Richard; Freilich, Daniel

    2011-08-01

    Sodium nitrite (NaNO(2)) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three 10 ml/kg infusions of either HBOC-201 or Hextend with and without NaNO(2). All vital signs, coagulation and blood chemistry were measured for 2 hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8 μmol/kg NaNO(2) infusion. Complete abolition was obtained with the highest 3 NaNO(2) dose, but side effects were observed. There was no reduction in platelet function due to NaNO(2). NaNO(2) ability to reduce HBOC-201 vasoactivity was transient and 10.8 μmol/kg NaNO(2) seems an acceptable dose for further investigation.

  4. (-201) β-Gallium oxide substrate for high quality GaN materials

    KAUST Repository

    Roqan, Iman S.

    2015-03-13

    (-201) oriented β-Ga2O3 has the potential to be used as a transparent and conductive substrate for GaN-growth. The key advantages of Ga2O3 are its small lattice mismatches (4.7%), appropriate structural, thermal and electrical properties and a competitive price compared to other substrates. Optical characterization show that GaN layers grown on (-201) oriented β-Ga2O3 are dominated by intense bandedge emission with a high luminescence efficiency. Atomic force microscopy studies show a modest threading dislocation density of ~108 cm-2, while complementary Raman spectroscopy indicates that the GaN epilayer is of high quality with slight compressive strain. Room temperature time-findings suggest that the limitation of the photoluminescence lifetime (~500 ps) is due to nonradiative recombination arising from threading dislocation. Therefore, by optimizing the growth conditions, high quality material with significant optical efficiency can be obtained.

  5. The 160 Square Degree ROSAT Survey: The revised catalog of 201 clusters with spectroscopic redshifts

    DEFF Research Database (Denmark)

    Mullis, C.R.; McNamara, B.R.; Quintana, H.;

    2003-01-01

    We present the revised catalog of galaxy clusters detected as extended X-ray sources in the 160 Square Degree ROSAT Survey, including spectroscopic redshifts and X-ray luminosities for 200 of the 201 members. The median redshift is z(median) = 0.25, and the median X-ray luminosity is L-X,L-median......We present the revised catalog of galaxy clusters detected as extended X-ray sources in the 160 Square Degree ROSAT Survey, including spectroscopic redshifts and X-ray luminosities for 200 of the 201 members. The median redshift is z(median) = 0.25, and the median X-ray luminosity is L...

  6. Optimisation of Simultaneous Tl-201/Tc-99m Dual Isotope Reconstruction with Monte-Carlo-Based Scatter Correction

    Directory of Open Access Journals (Sweden)

    Tuija Kangasmaa

    2012-01-01

    Full Text Available Simultaneous Tl-201/Tc-99m dual isotope myocardial perfusion SPECT is seriously hampered by down-scatter from Tc-99m into the Tl-201 energy window. This paper presents and optimises the ordered-subsets-expectation-maximisation-(OS-EM- based reconstruction algorithm, which corrects the down-scatter using an efficient Monte Carlo (MC simulator. The algorithm starts by first reconstructing the Tc-99m image with attenuation, collimator response, and MC-based scatter correction. The reconstructed Tc-99m image is then used as an input for an efficient MC-based down-scatter simulation of Tc-99m photons into the Tl-201 window. This down-scatter estimate is finally used in the Tl-201 reconstruction to correct the crosstalk between the two isotopes. The mathematical 4D NCAT phantom and physical cardiac phantoms were used to optimise the number of OS-EM iterations where the scatter estimate is updated and the number of MC simulated photons. The results showed that two scatter update iterations and 105 simulated photons are enough for the Tc-99m and Tl-201 reconstructions, whereas 106 simulated photons are needed to generate good quality down-scatter estimates. With these parameters, the entire Tl-201/Tc-99m dual isotope reconstruction can be accomplished in less than 3 minutes.

  7. Optimisation of simultaneous tl-201/tc-99m dual isotope reconstruction with monte-carlo-based scatter correction.

    Science.gov (United States)

    Kangasmaa, Tuija; Kuikka, Jyrki; Sohlberg, Antti

    2012-01-01

    Simultaneous Tl-201/Tc-99m dual isotope myocardial perfusion SPECT is seriously hampered by down-scatter from Tc-99m into the Tl-201 energy window. This paper presents and optimises the ordered-subsets-expectation-maximisation-(OS-EM-) based reconstruction algorithm, which corrects the down-scatter using an efficient Monte Carlo (MC) simulator. The algorithm starts by first reconstructing the Tc-99m image with attenuation, collimator response, and MC-based scatter correction. The reconstructed Tc-99m image is then used as an input for an efficient MC-based down-scatter simulation of Tc-99m photons into the Tl-201 window. This down-scatter estimate is finally used in the Tl-201 reconstruction to correct the crosstalk between the two isotopes. The mathematical 4D NCAT phantom and physical cardiac phantoms were used to optimise the number of OS-EM iterations where the scatter estimate is updated and the number of MC simulated photons. The results showed that two scatter update iterations and 10(5) simulated photons are enough for the Tc-99m and Tl-201 reconstructions, whereas 10(6) simulated photons are needed to generate good quality down-scatter estimates. With these parameters, the entire Tl-201/Tc-99m dual isotope reconstruction can be accomplished in less than 3 minutes.

  8. Codon 201 Mutation of DCC Gene and Tumor Biologic Behavior in Human Colorectal Carcinoma

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective To explore the relationship between a point mutation of codon 201 in deleted in colorectal carcinoma ( DCC) gene and the biological behavior of colorectal carcinoma. Methods Tumor tissues and matched adjacent normal colon mucosa collected in 35 patients during surgical resection for colorectal carcinoma were analyzed. Forty normal colon mucosa tissues obtained by biopsy from patients who had neither colorectal tumor nor a family history of colorectal cancer during colonscop ic examination were used as control. Codon 201 mutatian was detected with allele-specific PCR and a restriction enzyme digestion method. The tumors were reviewed as clinical data, tumor location, histology,metastasis, and pathological staging (Dukes classification). Results The frequency of mutation at codon 201 in tumor tissue and corresponding adjacent normal mucosa was 71.4 % and 60 %, respectively, and either of the rates was significantly higher than that of normal control(32.5 % ). The point mutation rate in tumor tissues did not differ from that in the corresponding normal adjacent tissues. Statistic analysis showed that the mutation rate had no relationship to the sex, age of the patients, the histological pattern , differentiation, and invasion depth of the tumors. However, 93. 8 % of the mutation rate in colorectal cancer with lymph node invasion and/or distant metastasis is significantly higher than 52. 6 % of mutant rate in colorectal cancer uithout lymph nodes invasion or metastasis ( P <0. 05). Conclusion The point mutation at codon 201 of DCC gene is an early genetic event in colorectal cancer, and play some role in invasion and metastasis of colorectal carcinoma. It may serve as a useful genetic marker for identifying higher risk patients with colorectal carcinoma.

  9. Codon 201 Mutation of DCC Gene and Tumor Biologic Behavior in Human Colorectal Carcinoma

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Objective To explore the relationship between a point mutation of codon 201 in deleted in colorectal carcinoma ( DCC) gene and the biological behavior of colorectal carcinoma. Methods Tumor tissues and matched adjacent normal colon mucosa collected in 35 patients during surgical resection for colorectal carcinoma were analyzed. Forty normal colon mucosa tissues obtained by biopsy from patients who had neither colorectal tumor nor a family history of colorectal cancer during colonscop ic examination were used as control. Codon 201 mutatian was detected with allele-specific PCR and a restriction enzyme digestion method. The tumors were reviewed as clinical data, tumor location, histology,metastasis, and pathological staging (Dukes classification). Results The frequency of mutation at codon 201 in tumor tissue and corresponding adjacent normal mucosa was 71.4 % and 60 %, respectively, and either of the rates was significantly higher than that of normal control(32.5 % ). The point mutation rate in tumor tissues did not differ from that in the corresponding normal adjacent tissues. Statistic analysis showed that the mutation rate had no relationship to the sex, age of the patients, the histological pattern , differentiation, and invasion depth of the tumors. However, 93. 8 % of the mutation rate in colorectal cancer with lymph node invasion and/or distant metastasis is significantly higher than 52. 6 % of mutant rate in colorectal cancer uithout lymph nodes invasion or metastasis ( P <0. 05). Conclusion The point mutation at codon 201 of DCC gene is an early genetic event in colorectal cancer, and play some role in invasion and metastasis of colorectal carcinoma. It may serve as a useful genetic marker for identifying higher risk patients with colorectal carcinoma.

  10. POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking

    Science.gov (United States)

    Schindler, Roland F.R.; Scotton, Chiara; Zhang, Jianguo; Passarelli, Chiara; Ortiz-Bonnin, Beatriz; Simrick, Subreena; Schwerte, Thorsten; Poon, Kar-Lai; Fang, Mingyan; Rinné, Susanne; Froese, Alexander; Nikolaev, Viacheslav O.; Grunert, Christiane; Müller, Thomas; Tasca, Giorgio; Sarathchandra, Padmini; Drago, Fabrizio; Dallapiccola, Bruno; Rapezzi, Claudio; Arbustini, Eloisa; Di Raimo, Francesca Romana; Neri, Marcella; Selvatici, Rita; Gualandi, Francesca; Fattori, Fabiana; Pietrangelo, Antonello; Li, Wenyan; Jiang, Hui; Xu, Xun; Bertini, Enrico; Decher, Niels; Wang, Jun; Brand, Thomas; Ferlini, Alessandra

    2015-01-01

    The Popeye domain–containing 1 (POPDC1) gene encodes a plasma membrane–localized cAMP-binding protein that is abundantly expressed in striated muscle. In animal models, POPDC1 is an essential regulator of structure and function of cardiac and skeletal muscle; however, POPDC1 mutations have not been associated with human cardiac and muscular diseases. Here, we have described a homozygous missense variant (c.602C>T, p.S201F) in POPDC1, identified by whole-exome sequencing, in a family of 4 with cardiac arrhythmia and limb-girdle muscular dystrophy (LGMD). This allele was absent in known databases and segregated with the pathological phenotype in this family. We did not find the allele in a further screen of 104 patients with a similar phenotype, suggesting this mutation to be family specific. Compared with WT protein, POPDC1S201F displayed a 50% reduction in cAMP affinity, and in skeletal muscle from patients, both POPDC1S201F and WT POPDC2 displayed impaired membrane trafficking. Forced expression of POPDC1S201F in a murine cardiac muscle cell line (HL-1) increased hyperpolarization and upstroke velocity of the action potential. In zebrafish, expression of the homologous mutation (popdc1S191F) caused heart and skeletal muscle phenotypes that resembled those observed in patients. Our study therefore identifies POPDC1 as a disease gene causing a very rare autosomal recessive cardiac arrhythmia and LGMD, expanding the genetic causes of this heterogeneous group of inherited rare diseases. PMID:26642364

  11. POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking.

    Science.gov (United States)

    Schindler, Roland F R; Scotton, Chiara; Zhang, Jianguo; Passarelli, Chiara; Ortiz-Bonnin, Beatriz; Simrick, Subreena; Schwerte, Thorsten; Poon, Kar-Lai; Fang, Mingyan; Rinné, Susanne; Froese, Alexander; Nikolaev, Viacheslav O; Grunert, Christiane; Müller, Thomas; Tasca, Giorgio; Sarathchandra, Padmini; Drago, Fabrizio; Dallapiccola, Bruno; Rapezzi, Claudio; Arbustini, Eloisa; Di Raimo, Francesca Romana; Neri, Marcella; Selvatici, Rita; Gualandi, Francesca; Fattori, Fabiana; Pietrangelo, Antonello; Li, Wenyan; Jiang, Hui; Xu, Xun; Bertini, Enrico; Decher, Niels; Wang, Jun; Brand, Thomas; Ferlini, Alessandra

    2016-01-01

    The Popeye domain-containing 1 (POPDC1) gene encodes a plasma membrane-localized cAMP-binding protein that is abundantly expressed in striated muscle. In animal models, POPDC1 is an essential regulator of structure and function of cardiac and skeletal muscle; however, POPDC1 mutations have not been associated with human cardiac and muscular diseases. Here, we have described a homozygous missense variant (c.602C>T, p.S201F) in POPDC1, identified by whole-exome sequencing, in a family of 4 with cardiac arrhythmia and limb-girdle muscular dystrophy (LGMD). This allele was absent in known databases and segregated with the pathological phenotype in this family. We did not find the allele in a further screen of 104 patients with a similar phenotype, suggesting this mutation to be family specific. Compared with WT protein, POPDC1(S201F) displayed a 50% reduction in cAMP affinity, and in skeletal muscle from patients, both POPDC1(S201F) and WT POPDC2 displayed impaired membrane trafficking. Forced expression of POPDC1(S201F) in a murine cardiac muscle cell line (HL-1) increased hyperpolarization and upstroke velocity of the action potential. In zebrafish, expression of the homologous mutation (popdc1(S191F)) caused heart and skeletal muscle phenotypes that resembled those observed in patients. Our study therefore identifies POPDC1 as a disease gene causing a very rare autosomal recessive cardiac arrhythmia and LGMD, expanding the genetic causes of this heterogeneous group of inherited rare diseases.

  12. Thrombolysis in acute myocardial infarction using intracoronary streptokinase: assessment by thallium-201 scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Schuler, G.; Schwarz, F.; Hofmann, M.; Mehmel, H.; Manthey, J.; Maurer, W.; Rauch, B.; Herrmann, H.; Kubler, W.

    1982-09-01

    Twenty-one patients with acute myocardial infarction, admitted to the hospital within 4 hours after the onset of symptoms, were studied by seven-pinhole thallium-201 scintigraphy before and 1 hour and 24 hours after intracoronary fibrinolysis using streptokinase. The size of the thallium-201 perfusion defect was assessed from myocardial cross sections reconstructed from the riginal seven-pinhole data and expressed as a fraction of left ventricular circumference. Recanalization was achieved in 16 patients within 3.9 +/- 1.6 hours after onset of symptoms (group A). In these patients, the size of the perfusion defect had decreased from 36 +/- 17% to 19 +/- 15%(p<0.001) at 24 hours. No significant change was detected to redistribution at 1 hour after the intervention. In five patients, intracoronary fibrinolysis was unsuccessful, and the vessel remained occluded (group B). The thallium-201 perfusion defect affected 40 +/- 15% of the left ventricular circumference before the intervention; it remained virtually unchanged at 1 hour (37 +/- 16%) and at 24 hours (41 +/- 15%) after fibrinolysis. The perfusion defect was most reduced in patients with extensive collaterals supplying the ischemic area or with subtotal occlusion of the affected coronary artery. It is concluded that successful intracoronary fibrinolysis may reduce the size of the thallium-201 perfusion defect in many patients with acute myocardial infarction. One important factor in the final result may be the presence of residual coronary flow supplied by extensive collaterals or by subtotal occlusion of the affected coronary artery when reperfusion is achieved around 4 hours after the onset of symptoms.

  13. Far-infrared and submillimeter observations and physical models of the reflection nebula Cederblad 201

    NARCIS (Netherlands)

    Kemper, C; Spaans, M; Jansen, DJ; Hogerheijde, MR; van Dishoeck, EF; Tielens, AGGM

    1999-01-01

    Infrared Space Observatory (ISO) CC nl 158 mu m, [O I] 63 mu m, and H-2 9 and 17 mu m observations are presented of the reflection nebula Ced 201, which is a photon-dominated region (PDR) illuminated by a B9.5 star with a color temperature of 10,000 K (a cool PDR). In combination with ground-based [

  14. Phantom evaluation of simultaneous thallium-201/technetium-99m acquisition in single-photon emission tomography

    Energy Technology Data Exchange (ETDEWEB)

    Cao Zongjian [Department of Diagnostic Radiology, University of Maryland Medical Center, Baltimore, MD (United States); Chen, C.C. [Department of Diagnostic Radiology, University of Maryland Medical Center, Baltimore, MD (United States); Maunoury, C. [Department of Diagnostic Radiology, University of Maryland Medical Center, Baltimore, MD (United States); Holder, L.E. [Department of Diagnostic Radiology, University of Maryland Medical Center, Baltimore, MD (United States); Abraham, T.C. [Department of Diagnostic Radiology, University of Maryland Medical Center, Baltimore, MD (United States); Tehan, A. [Department of Diagnostic Radiology, University of Maryland Medical Center, Baltimore, MD (United States)

    1996-11-01

    This study investigated downscatter effects in cardiac single-photon emission tomographic studies with simultaneous thallium-201/technetium-99m acquisition, and evaluated a previously proposed subtraction technique for downscatter compensation. Ten studies were carried out with different defect sizes and locations and varying activity distributions using four energy windows: 70{+-}10% keV, 140{+-}10% keV, 100{+-}10% KeV, and 103{+-}16% keV. The subtraction technique used the 100- or 103-keV data to remove scattered {sup 99m}Tc counts from the 70-keV data. The size and contrast of infarcts in the dual-isotope 70-keV image were artificially decreased compared to those in the 140-keV image, caused by scattered {sup 99m}Tc counts that were comparable to the primary {sup 201}Tl counts in the 70-keV window. The subtraction technique produced larger defects and more heterogeneous activity in the myocardial wall in dual-isotope 70-keV images compared to the corresponding {sup 201}Tl-only images. These artifacts were caused by the markedly different spatial distributions of scattered {sup 99m}Tc counts in the 100-keV (or 103-keV) window as compared with the 70-keV window. It is concluded that scattered {sup 99m}Tc photons may cause overestimation of ischemia and myocardial viability in simultaneous dual-isotope patient studies. The proposed subtraction technique was inaccurate and produced image artifacts. Adequate downscatter compensation methods must be developed before applying simultaneous {sup 201}Tl/{sup 99m}Tc acquisition in clinical practice. (orig.). With 6 figs., 3 tabs.

  15. A COTS-derived NVG compatible 20.1" avionics display

    Science.gov (United States)

    Thomas, J.; Cavalcanti, A.

    2007-04-01

    Many avionics displays, particularly for cockpit applications require NVG compatibility. Unusually, the mission definition for a new maritime helicopter has identified a need for NVG compatibility for all of the mission-system displays, including the 20.1" diagonal, SXGA resolution Tactical Workstation Display (TWD) located in the rear cabin. This paper will describe some design tradeoff considerations and describe both some required and measured performance parameters.

  16. Can benign and malignant thyroid nodules be differentiated with thallium 201. Le thallium 201 permet-il de differencier le nodule thyroidien benin du nodule malin

    Energy Technology Data Exchange (ETDEWEB)

    Hermans, J.; Schmitz, A.; Merlo, P.; Bodart, F.; Beauduin, M. (Hopital de Jolimont, Haine-Saint-Paul (Belgium))

    1993-01-01

    The merits of Thallium 201 radionuclide scanning of the thyroid mentioned as soon as 1976 by PALERMO have been confirmed in the 16 last studies published in the international literature. Over 1601 examinations, authors showed that any cold nodule (Tc 99 m or 1 123) which preferentially fixes Thallium 201 as compared to surround thyroid tissue must be operated since some of them are thyroid cancer carriers, some others are carriers of a traditional follicular adenoma or Hurthle-cell adenoma, or a follicular adenoma associated with varied cell atypisms which make difficult the diagnosis between benign and malignant nodules. The analysis of the results published show a 91.3% sensitivity of this diagnosis test, all analysis methods being considered. In case of negative test, it allows eliminating the cancer risk by more than 97% (negative predictive value). Such an examination - as opposed to a cytology test on the isolated nodule only - is valid for any type of nodule, being isolated, multiple or a multinodular goitre where the degeneration risk is close to, or even higher than, that of isolated nodules. (authors).

  17. Tank 241-T-201, core 192 analytical results for the final report

    Energy Technology Data Exchange (ETDEWEB)

    Nuzum, J.L.

    1997-08-07

    This document is the final laboratory report for Tank 241-T-201. Push mode core segments were removed from Riser 3 between April 24, 1997, and April 25, 1997. Segments were received and extruded at 222-S Laboratory. Analyses were performed in accordance with Tank 241-T-201 Push Mode Core Sampling and Analysis Plan (TSAP) (Hu, 1997), Letter of Instruction for Core Sample Analysis of Tanks 241-T-201, 241-T-202, 241-T-203, and 241-T-204 (LOI) (Bell, 1997), Additional Core Composite Sample from Drainable Liquid Samples for Tank 241-T-2 01 (ACC) (Hall, 1997), and Safety Screening Data Quality Objective (DQO) (Dukelow, et al., 1995). None of the subsamples submitted for total alpha activity (AT) or differential scanning calorimetry (DSC) analyses exceeded the notification limits stated in DQO. The statistical results of the 95% confidence interval on the mean calculations are provided by the Tank Waste Remediation Systems Technical Basis Group, and are not considered in this report.

  18. Clinical evaluation of efonidipine hydrochloride in angina pectoris. Evaluation in exercise {sup 201}Tl myocardial scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Hori, Masatsugu; Nishimura, Tsunehiko [Osaka Univ., Suita (Japan). Medical School

    1996-12-01

    Clinical usefulness of once-daily administration of 20 to 60 mg of efonidipine hydrochloride and coronary hemodynamics during exercise {sup 201}Tl myocardial scintigraphy were investigated in patients with angina pectoris. Out of 11 patients enrolled in this study, 9 patients were included in the evaluation of patients` impression, in improvement rating in subjective symptoms, in the analysis of the exercise test, in the improvement rating of images on {sup 201}Tl myocardial scintigraphy, and in the global improvement rating, while 10 patients were included in the overall safety rating. Four patients in improvement rating in subjective symptoms, 2 in improving rating in the exercise test, and 5 in the global improvement rating were rated `improved` or better. In the improvement rating on the exercise {sup 201}Tl myocardial scintigraphy image, reduction of the image was observed in 5 patients, 3 out of which were evaluated as `improved` or better. A distinctive reduction of ischemic regions was observed in 2 patients out of the 3. A significant decrease in the number of angina pectoris events and a decreasing tendency in consumption of fast-acting nitrates were observed in spite of the low number of the patients studied. An adverse effect was observed in 1 patient and abnormal laboratory values were observed in 2 patients which were improved promptly after withdrawal of the drug. It was in 7 patients evaluated as `no problem`, while in 4 patients it was evaluated as `useful` or more. (author)

  19. The effect of captopril on thallium 201 myocardial perfusion in systemic sclerosis

    Energy Technology Data Exchange (ETDEWEB)

    Kahan, A.; Devaux, J.Y.; Amor, B.; Menkes, C.J.; Weber, S.; Venot, A.; Strauch, G. (Rene Descartes Univ., Paris (France))

    1990-04-01

    In systemic sclerosis, abnormalities of myocardial perfusion are common and may be caused by a disturbance of the coronary microcirculation. We evaluated the long-term effect of captopril (75 to 150 mg per day) on thallium 201 myocardial perfusion in 12 normotensive patients with systemic sclerosis. Captopril significantly decreased the mean (+/- SD) number of segments with thallium 201 myocardial perfusion defects (6.5 +/- 1.9 at baseline and 4.4 +/- 2.7 after 1 year of treatment with captopril; p less than 0.02) and increased the mean global thallium score (9.6 +/- 1.7 at baseline and 11.4 +/- 2.1 after captopril; p less than 0.05). In a control group of eight normotensive patients with systemic sclerosis who did not receive captopril, no significant modification in thallium results occurred. Side effects with captopril included hypotension (six patients), taste disturbances (one patient), and skin rash (one patient). These side effects subsided when the dosage was reduced. These findings demonstrate that captopril improves thallium 201 myocardial perfusion in patients with systemic sclerosis and may therefore have a beneficial effect on scleroderma myocardial disease.

  20. Optimum technique for /sup 201/Tl tomography of myocardium: an investigation using phantoms

    Energy Technology Data Exchange (ETDEWEB)

    Laird, E.E.; Williams, E.D.

    1987-08-01

    Rotating gamma-camera tomography is used for /sup 201/Tl perfusion imaging to detect myocardial ischaemia or infarction. Variables which can affect the utility of the images include acquisition time, collimator sensitivity and resolution, spatial filtering, reconstruction matrix and display parameters. An 'Iowa' design myocardial phantom containing /sup 201/Tl, with a defect representing an unperfused area, was used to study the effect of these variables. Receiver operator characteristic (ROC) curves and contrast ratios indicated that filtering the acquisition data with a count-dependent (Metz) filter before reconstruction and using a narrow slice width gave best results. No single collimator was superior for all four defect locations investigated but low-energy general purpose and high-resolution collimators were preferred to those with greater sensitivity. Reducing acquisition time by a factor of four compared with that for routine patient imaging affected contrast ratio, uniformity and area under ROC curves insignificantly, provided the optimum reconstruction was used. Displaying tomographic sections in colour gave no improvement in ROC curves over monochrome images. Data acquisition time or administered /sup 201/Tl radioactivity might therefore be reduced below the 25 min and 80 MBq often used for patient studies.

  1. Estimation of cardiac function by thallium-201 myocardial scintigraphy in mitral regurgitation

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Mitsunori (Ehime Univ., Shigenobu (Japan). School of Medicine)

    1993-12-01

    To estimate whether thallium-201 myocardioal scintigraphy is a valid method to evaluate cardiac condition in mitral regurgitation, thallium myocardial scintigraphy was performed in 24 patients with mitral regurgitation. The extent score was calculated as the index of thallium-201 myocardial scintigraphy. The extent score was high (28.7[+-]5.5%) and was significantly correlated with severity of mitral regurgitant flow volume. There were correlations among extent score and fractional shortening (r=-0.78, p<0.01), left ventricular end-systolic dimension (r=0.79, p<0.01) and end-systolic wall stress (r=0.68, p<0.01). Extent scores significantly decreased after the mitral valve replacement. The decrease in extent scores associated with mitral valve replacement was greater in patients with a smaller preoperative extent score and smaller in patients with a greater preoperative extent score. In conclusion, extent score obtained by thallium-201 myocardial scintigraphy accurately reflects the myocardial damages associated with mitral regurgitation, and it may be useful for predicting the postoperative prognosis. (author).

  2. Kinetic analysis of 18F-fluorodihydrorotenone as a deposited myocardial flow tracer: Comparison to thallium-201.

    Energy Technology Data Exchange (ETDEWEB)

    Marshall, Robert C.; Powers-Risius, Patricia; Reutter, Bryan W.; O' Neil, James P.; La Belle, Michael; Huesman, Ronald H.; VanBrocklin, Henry F.

    2004-03-01

    The goal of this investigation was to assess the accuracy of 18F-fluorodihydrorotenone (18F-FDHR) as a new deposited myocardial flow tracer and compare the results to those for 201Tl. Methods. The kinetics of these flow tracers were evaluated in 22 isolated, erythrocyte- and albumin-perfused rabbit hearts over a flow range encountered in patients. The two flow tracers plus a vascular reference tracer (131I-albumin) were introduced as a bolus through a port just above the aortic cannula. Myocardial extraction, retention, washout, and uptake parameters were computed from the venous outflow curves using the multiple indicator dilution technique and spectral analysis. Results. The mean initial extraction fractions of 18F-FDHR (0.85 +- 0.07) and 201Tl (0.87 +- 0.05) were not significantly different, although the initial extraction fraction for 18F-FDHR declined with flow (P < 0.0001), whereas the initial extraction fraction of 201Tl did not. Washout of 201Tl was faster (P < 0.001) and more affected by flow (P < 0.05) than 18F-FDHR washout. Except for initial extraction fraction, 18F-FDHR retention was greater (P < 0.001) and less affected by flow (P < 0.05) than 201Tl retention. Reflecting its superior retention, net uptake of 18F-FDHR was better correlated with flow than 201Tl uptake at both one and fifteen minutes after tracer introduction (P < 0.0001 for both comparisons). Conclusion. The superior correlation of 18F-FDHR uptake with flow indicates that it is a better flow tracer than 201Tl in the isolated rabbit heart. Compared to the other currently available positron-emitting flow tracers (82Rb, 13N-ammonia, and 15O-water), 18F-FDHR has the potential of providing excellent image resolution without the need for an on-site cyclotron.

  3. Relation between regional distribution of /sup 201/Tl and myocardial blood flow in normal, acutely ischemic, and infarcted myocardium

    Energy Technology Data Exchange (ETDEWEB)

    Chu, A.; Murdock, R.H. Jr.; Cobb, F.R.

    1982-11-01

    Myocardial localization of /sup 201/Tl was compared with direct measurements of myocardial perfusion in normal, acutely ischemic, and recently infarcted myocardium. Studies were performed in 6 chronically instrumented dogs that were subjected to myocardial infarction by occlusion of the proximal left circumflex coronary artery. Four days after myocardial infarction, /sup 201/Tl and 9 +/- 1 micrometer /sup 95/Nb-labelled microspheres were injected simultaneously after acute left anterior descending coronary arterial occlusion; the animals were killed 5 minutes later and the entire left ventricle was sectioned into 1 to 2 g samples. Regression analyses between /sup 201/Tl activity and regional myocardial blood flow using all myocardial samples demonstrated a very close linear relation in each dog; r values were 0.98 or greater, indicating that the initial localization of /sup 201/Tl in acutely ischemic and recently infarcted myocardium as a function of regional blood flow was essentially identical. Consequently, in each dog the regional distribution of /sup 201/Tl closely approximated myocardial perfusion over a wide range of blood flow and potentially different local metabolic conditions that may be encountered in the clinical use of the isotope.

  4. Effect of beta blockade on single photon emission computed tomographic (SPECT) thallium-201 images in patients with coronary disease

    Energy Technology Data Exchange (ETDEWEB)

    Narahara, K.A.; Thompson, C.J.; Hazen, J.F.; Brizendine, M.; Mena, I.

    1989-05-01

    We evaluated the effect of beta blockers on thallium-201 (Tl-201) single photon emission computed tomographic (SPECT) imaging in 12 patients with coronary disease using an automated computer algorithm. Maximal exercise heart rate and blood pressure were reduced and exercise time was increased with beta blockers. Estimated stress defect size decreased from 47 +/- 36.3 gm during placebo treatment to 32 +/- 27.1 gm during beta blocker therapy (-32%; p less than 0.01). The placebo treatment redistribution defect was estimated to be 28 +/- 29.8 gm. It fell to 15 +/- 23.3 gm with beta blockade (-46%; p less than 0.005). All patients had a stress Tl-201 defect during placebo treatment and eight had redistribution defects consistent with residual scar. During beta blocker therapy, 2 of 12 patients had normal stress-redistribution studies and only five patients had redistribution defects. Beta blockade can reduce exercise and redistribution Tl-201 SPECT defect size significantly while simultaneously increasing exercise time and reducing angina. Beta blockers may unmask or may eliminate evidence of redistribution. Tl-201 SPECT imaging may be useful in defining the reduction in ischemia produced by cardiac drugs.

  5. Removal of {sup 99m}Tc and {sup 201}Tl by means of Lemna Gibba; Remocion de {sup 99m}Tc y {sup 201}Tl mediante Lemna Gibba

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez R, E.; Carreno de L, M. C.; Cuevas S, J. C.; Hernadez T, U. O. [Instituto Tecnologico de Toluca, Av. Tecnologico s/n, Fraccionamiento La Virgen, 52149 Metepec, Estado de Mexico (Mexico); Monroy G, F., E-mail: edelmiraf@yahoo.com [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2012-10-15

    In this work the capacity of the water macrophyte Lemna gibba coming from San Pedro Tultepec in the Mexico State was studied to remove the radioisotopes {sup 99m}Tc and {sup 201}Tl, in order to show the capacity of this macrophyte for to treat some radioactive waste flowing that could contain this radioisotopes type. The removal capacity of {sup 99m}Tc and {sup 201}Tl of the macrophyte Lemna gibba was determined using the batch method. In accordance with the values of the obtained K{sub d}, the Lemna gibba with a size of particle diameter among 1mm - 300 {mu}m presents a better adsorption of {sup 99m}Tc. The {sup 201}Tl is adsorbed better in the bioadsorbent when it has a size of particle diameter <150{mu}m. (Author)

  6. Clinical usefulness of thallium-201 myocardial scintigraphy for the diagnosis of chronic cor pulmonale

    Energy Technology Data Exchange (ETDEWEB)

    Hirayama, Jiro

    1987-06-01

    In order to evaluate right ventricular overloading(RVO) and hypertrophy, thallium-201 myocardial scintigraphy applying a new quantitative method was performed on 17 patients with chronic respiratory diseases, 13 autopsy cases and 30 normal subjects. Thallium-201 uptake ratio of left and right ventricular myocardium to the administered dose (LT, RT) were measured scintigraphically, and RT and LT/RT ratio were compared with pulmonary hemodynamic findings and with heart weight measured at autopsy. Mean pulmonary arterial pressure (MPAP) in 17 patients was significantly correlated both with RT (r = 0.78, p < 0.001) and with LT/RT ratio (r = -0.87, p < 0.001). Based on the results of investigations on 30 normal subjects, these patients could be divided into two groups as follows : RVO group (RT greater than or equal to 1.1 and/or LT/RT less than or equal to 2.7) and non-RVO group (RT < 1.1 and LT/RT > 2.7). The patients in the RVO group showed a significantly higher MPAP than those in the non-RVO group (p < 0.01). The efficiency of this method for the diagnosis of pulmonary hypertension (MPAP greater than or equal to 20 mmHg) was eighty-eight percent. In addition, there were significant correlations between RT and the weight of right cardiac mass (r = 0.97, p < 0.001) as well as between LT/RT ratio and the ratio of the weight of left to right cardiac mass (r = 0.94, p < 0.001) in 13 autopsy cases. Thallium-201 myocardial scintigraphy using this quantitative method may be useful for the estimation of right ventricular overloading and hypertrophy in chronic respiratory diseases.

  7. Development and Production of a 201 MHz, 5.0 MW Peak Power Klystron

    Energy Technology Data Exchange (ETDEWEB)

    Aymar, Galen [Communications & Power Industries, Palo Alto, CA (United States); Eisen, Edward [Communications & Power Industries, Palo Alto, CA (United States); Stockwell, Brad [Communications & Power Industries, Palo Alto, CA (United States); Begum, rasheda [Communications & Power Industries, Palo Alto, CA (United States); Lenci, Steve [Communications & Power Industries, Palo Alto, CA (United States); Eisner, Rick [Communications & Power Industries, Palo Alto, CA (United States); Cesca, Eugene [Communications & Power Industries, Palo Alto, CA (United States)

    2016-01-01

    Communications & Power Industries LLC has designed and manufactured the VKP-8201A, a high peak power, high gain, VHF band klystron. The klystron operates at 201.25 MHz, with 5.0 MW peak output power, 34 kW average output power, and a gain of 36 dB. The klystron is designed to operate between 1.0 MW and 4.5 MW in the linear range of the transfer curve. The klystron utilizes a unique magnetic field which enables the use of a proven electron gun design with a larger electron beam requirement. Experimental and predicted performance data are compared.

  8. Development of moving target detection algorithm using ADSP TS201 DSP Processor

    Directory of Open Access Journals (Sweden)

    Babu rao Kodavati

    2010-08-01

    Full Text Available This paper presents detect the presence of a target within a specified range(2 to 30m. The present work generally relates to a radar system and more particularly, to improve range resolution (3 m and minimum detection time (2 msec. Speed and accuracy are two important evaluation indicators in target detecting system. The challenges in developing the algorithm is finding the Doppler frequency and give caution signal to chief at an optimum instant of time to cause target kill. Time management serves to maintain a priority queue of all the tasks. In this work we have taken up issue of developing an algorithm using ADSP TS 201 DSP Processor.

  9. LPIC-2 Linux Professional Institute Certification Study Guide Exams 201 and 202

    CERN Document Server

    Smith, Roderick W

    2011-01-01

    The first book to cover the LPIC-2 certification Linux allows developers to update source code freely, making it an excellent, low-cost, secure alternative to alternate, more expensive operating systems. It is for this reason that the demand for IT professionals to have an LPI certification is so strong. This study guide provides unparalleled coverage of the LPIC-2 objectives for exams 201 and 202. Clear and concise coverage examines all Linux administration topics while practical, real-world examples enhance your learning process. On the CD, you'll find the Sybex Test Engine, electronic flash

  10. Application of Seismic Data to Reservoir Modeling of the Chegu 201 Block

    Institute of Scientific and Technical Information of China (English)

    CaiYi; ZhangXiangzhong; ZhangXinshang

    2005-01-01

    Great uncertainty exists in reservoir models built for blocks where well spacing is uneven or large. The uncertainty in reservoir models can be significantly reduced by using Coordinate Cokriging Sequential Gaussian Simulation technology, in combination with the restriction of seismic characteristic data. Satisfactory reservoir parameter interpolation results, which are more accurate than those derived only from borehole data, are obtained, giving rise to a reasonable combination of widespread and dense-sampled seismic (soft data) data with borehole data (hard data). A significant effect has been made in reservoir parameter modeling in the Chegu 201 block of the Futai Oilfield by using this technology.

  11. Reactions sup 58,64 Ni( p ,. pi. sup + ) at 201 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Badala, A.; Barbera, R.; Palmeri, A.; Pappalardo, G.S.; Bonasera, A. (Istituto Nazionale di Fisica Nucleare, Corso Italia 57, 95129 Catania (Italy)); Riggi, F.; Adorno, A. (Istituto Nazionale di Fisica Nucleare and Dipartimento di Fisica dell' Universita di Catania, Corso Italia 57, 95129 Catania (Italy)); Bimbot, L. (Institut de Physique Nucleaire, Boite Postale 1, 91406 Orsay CEDEX (France))

    1992-08-01

    The production of positive and negative pions induced by 201 MeV protons on {sup 58}Ni and {sup 64}Ni isotopes has been studied. The double differential cross sections have been measured at the laboratory angles 22{degree}, 35{degree}, 55{degree}, 72{degree}, 90{degree}, 105{degree}, 120{degree}, 138{degree}, 155{degree} and from 20 MeV kinetic energy up to the kinematical limit. Features of the double differential cross sections relative to the two targets are discussed and compared to results obtained at higher incident energies.

  12. Pharmacological profile of the abeorphine 201-678, a potent orally active and long lasting dopamine agonist

    Energy Technology Data Exchange (ETDEWEB)

    Jaton, A.L.; Giger, R.K.A.; Vigouret, J.M.; Enz, A.; Frick, W.; Closse, A.; Markstein, R.

    1986-01-13

    The central dopaminergic effects of an abeorphine derivative 201-678 were compared to those of apomorphine and bromocriptine in different model systems. After oral administration, this compound induced contralateral turning in rats with 6-hydroxydopamine induced nigral lesions and exhibited strong anti-akinetic properties in rats with 6-hydroxydopamine induced hypothalamic lesions. It decreased dopamine metabolism in striatum and cortex, but did not modify noradrenaline and serotonin metabolism in the rat brain. 201-678 counteracted the in vivo increase of tyrosine hydroxylase activity induced by ..gamma..-butyrolactone. In vitro it stimulated DA-sensitive adenylate cyclase and inhibited acetylcholine release from rat striatal slices. This compound had high affinity for /sup 3/H-dopamine and /sup 3/H-clonidine binding sites. These results indicate that 201-678 is a potent, orally active dopamine agonist with a long duration of action. Furthermore it appears more selective than other dopaminergic drugs. 29 references, 5 figures, 3 tables.

  13. Activity determination of a {sup 201}Tl solution by 4πβ-γ and sum-peak coincidence methods

    Energy Technology Data Exchange (ETDEWEB)

    Ruzzarin, Anelise; Lopes, Ricardo Tadeu, E-mail: aruzzarin@nuclear.ufrj.br [Coordenacao dos Cursos de Pos-Graduacao em Engenharia (LIN/PEN/COPPE/UFRJ), RJ (Brazil). Programa de Engenharia Nuclear. Lab. de Instrumentacao Nuclear; Silva, Monica A. L. da [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Iwahara, Akira; Silva, Ronaldo L. da; Filho, Octavio L.T.; Poledna, Roberto [Instituto de Radioprotecao e Dosimetria (LNMRI/IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Lab. Nacional de Metrologia das Radiacoes Ionizantes

    2015-07-01

    {sup 201}Tl is used in nuclear medicine in cardiac imaging for evaluating the injury level in cardiac muscle at rest and exercise. In this work the activity concentration of a {sup 201}Tl radioactive solution has been absolutely determined using the 4πβ-γ coincidence and sum-peak coincidence methods. The presence of {sup 202}Tl radioactive impurity that imposes some difficult in the activity measurements was taken into account in the measurements. In the sum-peak method a planar germanium detector was used. The half-lives were evaluated by the reference source method and the results obtained were (3.033 ± 0.004) d and (12.320 ± 0.163) d, respectively, for {sup 201}Tl and {sup 202}Tl. (author)

  14. Detection of culprit lesion in patients with unstable angina pectoris by using ATP thallium-201 myocardial SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kasai, Tokuo; Mori, Yutaka [Jikei Univ., Tokyo (Japan). School of Medicine; Yamashina, Akira; Kubo, Toru; Usui, Yasuhiro

    1999-10-01

    The purpose of this study is to determine the diagnostic accuracy for detection of culprit lesions in patients with unstable angina. Both ATP {sup 201}Tl SPECT and coronary angiography were performed in 51 patients with unstable angina pectoris within a week since the last attack. SPECT images were divided into 17 segments and the regional uptakes were scored semiquantitatively (0=normal to 3=no activity) and compared with the coronary angiographic findings. ATP {sup 201}Tl SPECT revealed decreased uptakes in 54 of 56 culprit lesions. The sensitivity, specificity and accuracy for detection of culprit lesions were 96.4%, 89.5% and 92.4%, respectively. Although adverse effects during ATP administration were complicated in 28 (54.9%) patients, all the complications were mild and resolved within two minutes. ATP {sup 201}Tl SPECT is sensitive and reliable method for detecting culprit lesions and can be performed safely even at acute phase in patients with unstable angina pectoris. (author)

  15. Single injection thallium-201 stress and redistribution myocardial perfusion imaging: comparison with stress electrocardiography and coronary arteriography

    Energy Technology Data Exchange (ETDEWEB)

    Sonnemaker, R.E. (Army Medical Center, El Paso, TX); Floyd, J.L.; Nusynowitz, M.L.; Bode, R.F.; Spicer, M.J.; Waliszewski, J.A.

    1979-04-01

    The efficacy of single injection thallium-201 exercise stress and rest redistribution imaging in the evaluation of myocardial ischemia was compared with stress electrocardiography and coronary arteriography. Thallium-201 imaging was interpreted at two levels of sensitivity in order to define the circumstances under which it best serves as a screening modality for coronary arteriography. With the prevalence of coronary disease usually found in patients referred for coronary arteriography (75%), unprocessed thallium-201 imaging is as good as stress electrocardiography in identifying patients apt to show coronary artery abnormalities, but not much better than stress electrocardiography in delineating those patients unlikely to show coronary artery disease. In contrast, processed lesion enhanced images showing normal results virtually eliminate the possibility of significant arteriographic findings. With this screening technique, many patients may be spared unnecessary coronary arteriography.

  16. Activity determination of a 201Tl solution by 4πβ-γ and sum-peak coincidence methods

    Science.gov (United States)

    Ruzzarin, A.; da Silva, M. A. L.; Iwahara, A.; da Silva, R. L.; Filho, O. L. T.; Poledna, R.; Lopes, R. T.

    2016-07-01

    201Tl is used in nuclear medicine in cardiac imaging for evaluating the injury level in cardiac muscle at rest and exercise. In this work the activity concentration of a 201 Tl radioactive solution has been absolutely determined using the 4πβ-γ coincidence and sum-peak coincidence methods. The presence of 202Tl radioactive impurity that imposes some difficult in the activity measurements was taken into account in the measurements. In the sum-peak method a planar germanium detector was used. The half-lives were evaluated by the reference source method and the results obtained were (3.033 ± 0.004) d and (12.320 ± 0.163) d, respectively, for 201Tl and 202Tl.

  17. Disease stage classification in hypertrophic cardiomyopathy by dual analysis of iodine-123-labeled metaiodobenzylguanidine and thallium-201 myocardial scintigraphies

    Energy Technology Data Exchange (ETDEWEB)

    Hiasa, Go [Ehime Univ., Matsuyama (Japan). School of Medicine

    2001-08-01

    Many patients with hypertrophic cardiomyopathy (HCM) gradually changes from typical myocardial hypertrophy to dilated cardiomyopathy-like features. However, it is difficult to estimate the disease stage in HCM. To determine the disease stage, dual analysis of iodine-123-labeled metaiodobenzylguanidine ({sup 123}I-MIBG) and thallium-201 ({sup 201}Tl) myocardial scintigraphies were performed in 108 HCM patients. According to the scintigraphic distribution patterns, patients were divided into three groups. Group A (n=15): normal distributions of both {sup 123}I-MIBG and {sup 201}Tl, group B (n=71): normal {sup 201}Tl and low {sup 123}I-MIBG patterns, group C (n=22): low distributions of both scintigraphies. The decrease in {sup 201}Tl uptake was observed in only group C. Concerning {sup 123}I-MIBG, heart-to-mediastinum ratio (H/M) and washout rate (WOR) had good correlations with left ventricular systolic functions. H/M was decreased and WOR was increased in order of C, B and A groups. Left ventricular diastolic function reflected by isovolumic relaxation time was longer in group B than in group A. Attenuated left ventricular hypertrophy, enlarged left ventricular volumes, impaired left ventricular functions and serious clinical symptoms were observed in only group C. Myocardial sympathetic abnormalities in group B may be mainly due to myocardial hypertrophy, and those in group C may be due to myocardial injury. Dual analysis of {sup 123}I-MIBG and {sup 201}Tl scintigraphies may be useful to classify disease stages of HCM. (author)

  18. 19 CFR 201.37 - Changing the time, place, subject matter, or determination to open or close a meeting following a...

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Changing the time, place, subject matter, or... Public Observation Pursuant to 5 U.S.C. 552b § 201.37 Changing the time, place, subject matter, or... amendment to the public notice as required by § 201.35. (b) The subject matter or matters of a...

  19. 21 CFR 201.21 - Declaration of presence of phenylalanine as a component of aspartame in over-the-counter and...

    Science.gov (United States)

    2010-04-01

    ... component of aspartame in over-the-counter and prescription drugs for human use. 201.21 Section 201.21 Food... component of aspartame in over-the-counter and prescription drugs for human use. (a) Aspartame is the... acids are so combined to form aspartame (1-methyl N-L-α-aspartyl-L-phenylalanine), they produce...

  20. Complete Genome Sequence of a Gluconacetobacter hansenii ATCC 23769 Isolate, AY201, Producer of Bacterial Cellulose and Important Model Organism for the Study of Cellulose Biosynthesis.

    Science.gov (United States)

    Pfeffer, Sarah; Mehta, Kalpa; Brown, R Malcolm

    2016-08-11

    The cellulose producer and model organism used for the study of cellulose biosynthesis, Gluconacetobacter hansenii AY201, is a variant of G. hansenii ATCC 23769. We report here the complete nucleotide sequence of G. hansenii AY201, information which may be utilized to further the research into understanding the genes necessary for cellulose biosynthesis.

  1. Draft Genome Sequence of a Moderately Halophilic Bacillus megaterium Strain, MSP20.1, Isolated from a Saltern of the Little Rann of Kutch, India

    Science.gov (United States)

    Dey, Rinku; Sherathia, Dharmesh; Vanpariya, Sejal; Patel, Ilaxi; Dalsania, Trupti; Savsani, Kinjal; Sukhadiya, Bhoomika; Mandaliya, Mona; Thomas, Manesh; Ghorai, Sucheta; Rupapara, Rupal; Rawal, Priya; Shah, Abhi; Bhayani, Sharmila

    2014-01-01

    The 4.37-Mbp draft genome of a moderately halophilic Bacillus megaterium strain, MSP20.1, isolated from a saltern of the Little Rann of Kutch, India, is reported here. To understand the mechanism(s) of moderate halophilism and to isolate the gene(s) involved in osmotolerance and adaptation, the genome of MSP20.1 was sequenced. PMID:24407642

  2. Management of patients with thyroid carcinoma: Application of thallium-201 scintigraphy and magnetic resonance imaging

    Energy Technology Data Exchange (ETDEWEB)

    Burman, K.D.; Anderson, J.H.; Wartofsky, L.; Mong, D.P.; Jelinek, J.J. (Walter Reed Army Medical Center, Washington, DC (USA))

    1990-12-01

    Thyroid carcinoma has the ability to concentrate radioiodine, an attribute that can be used both for detection of thyroid cells and for treatment. Unfortunately, however, radioiodine uptake is not observed in all patients and a radioiodine scan requires that the patient be rendered hypothyroid for 4-6 wk. In the present study, we analyzed the utility of thallium-201 scanning and the usefulness of magnetic resonance imaging (MRI) in the detection of thyroid cancer. Nineteen patients with thyroid cancer had a total of 24 radioiodine scans, 33 thallium scans, and 10 MRI examinations. Of the 19 patients in the study, 17 had differentiated thyroid carcinoma. In these 17 cases, all paired studies were concordant for the presence (n = 7) or absence (n = 10) of disease. However, in one case (Patient 10), the {sup 201}Tl studies showed far more extensive disease than was observed on the {sup 131}I scan. Thyroid cancer was also detected on seven MRI studies. In summary, thallium and MRI scans are adjunctive techniques to radioiodine scanning that can either confirm the presence of neck bed activity, residual disease or metastatic cancer and may delineate tumor deposits not detected by radioiodine scanning. Thallium may be capable of detecting tumor deposits even while a patient remains euthyroid.

  3. Qualitative evaluation of coronary flow during anesthetic induction using thallium-201 perfusion scans

    Energy Technology Data Exchange (ETDEWEB)

    Kleinman, B.; Henkin, R.E.; Glisson, S.N.; el-Etr, A.A.; Bakhos, M.; Sullivan, H.J.; Montoya, A.; Pifarre, R.

    1986-02-01

    Qualitative distribution of coronary flow using thallium-201 perfusion scans immediately postintubation was studied in 22 patients scheduled for elective coronary artery bypass surgery. Ten patients received a thiopental (4 mg/kg) and halothane induction. Twelve patients received a fentanyl (100 micrograms/kg) induction. Baseline thallium-201 perfusion scans were performed 24 h prior to surgery. These scans were compared with the scans performed postintubation. A thallium-positive scan was accepted as evidence of relative hypoperfusion. Baseline hemodynamic and ECG data were obtained prior to induction of anesthesia. These data were compared with the data obtained postintubation. Ten patients developed postintubation thallium-perfusion scan defects (thallium-positive scan), even though there was no statistical difference between their baseline hemodynamics and hemodynamics at the time of intubation. There was no difference in the incidence of thallium-positive scans between those patients anesthetized by fentanyl and those patients anesthetized with thiopental-halothane. The authors conclude that relative hypoperfusion, and possibly ischemia, occurred in 45% of patients studied, despite stable hemodynamics, and that the incidence of these events was the same with two different anesthetic techniques.

  4. Effect of cardiac drugs on imaging studies with thallous chloride Tl 201

    Energy Technology Data Exchange (ETDEWEB)

    Waschek, J.; Hinkle, G.; Basmadjian, G.; Allen, E.W.; Ice, R.

    1981-11-01

    The effects of commonly used cardiac drugs on cardiac imaging with thallium-201-labeled thallous chloride were studied. This retrospective study included 62 men ranging in age from 37 to 70 years who had cardiac imaging attempted with thallium during an eight-month period. Seven drugs were being used by at least eight patients each--propranolol, nitroglycerin ointment, isosorbide dinitrate, digoxin, hydrochlorothiazide, potassium chloride, and quinidine. Myocardial-to-background (M/Bk) ratios were calculated for each patient. No drug consistently affected the M/Bk ratios. The lowest M/Bk ratio was found in patients receiving digoxin, but there was no significant difference between the M/Bk ratios for patients taking digoxin (1.38 +/- 0.16) and those not taking digoxin (1.45 +/- 0.10) (0.05 less than p less than 0.10, Student's t test). It is concluded that the drugs studied do not affect cardiac imaging with thallous chloride Tl 201.

  5. Myocardial perfusion imaging with technetium-99m SQ30217: Comparison with thallium-201 and coronary anatomy

    Energy Technology Data Exchange (ETDEWEB)

    Seldin, D.W.; Johnson, L.L.; Blood, D.K.; Muschel, M.J.; Smith, K.F.; Wall, R.M.; Cannon, P.J.

    1989-03-01

    Myocardial perfusion in ten normal volunteers and 20 patients with coronary artery disease documented by recent coronary arteriography was studied with 99mTc-labeled SQ30217 and /sup 201/TI. Plantar /sup 201/TI imaging followed standard treadmill exercise and planar SQ30217 imaging followed upright bicycle exercise, performed to angina, or the same double product achieved on the treadmill test. Upright anterior, 30 degrees left anterior oblique, and 60 degrees left anterior oblique images were obtained for 3, 6, and 9 min, respectively, starting 2 min after injection of 15 mCi of 99mTc SQ30217. A second 15-mCi dose was injected at rest approximately 2 hr later, and the same imaging protocol was followed. No adverse reactions or laboratory abnormalities attributable to SQ30217 were observed. All scans on the normal volunteers were interpreted as normal. Qualitative readings of both tests were equally sensitive for detecting patients with coronary disease (SQ30217 - 16/20, TI - 17/20, p = NS) and identifying abnormal vessels (SQ30217 - 19/45, TI - 21/45, p = NS). Both agents were falsely positive in 1/15 vessels. Ten vascular regions showed persistent abnormalities on resting SQ30217 scans; eight of these were distal to stenoses of at least 90% and three were also abnormal on thallium redistribution images. Hepatic uptake of SQ30217 obscured inferoapical segments in some views in 14/20 patients but did not interfere with abnormal vessel identification.

  6. Cardiac morphology in left ventricular hypertrophy using thallium-201 myocardial scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Torii, Yukio; Adachi, Haruhiko; Katsume, Hiroshi; Ochiai, Masakazu; Ijichi, Hamao

    1985-06-01

    To evaluate cardiac morphology in the patients with various cases of hypertrophy, we measured left ventricular (LV) size using thallium-201 myocardial scintigraphy in 29 normal subjects and in 90 patients. Cardiac shape and dimension were assessed by measuring the wall thickness and external length in the short and long axis of LV image in LAO projection. In aortic stenosis and hypertensive heart disease the shape was spherical and the wall was thickened. In both mitral (MR) and aortic (AR) regurgitations, LV dilatation were shown; spherical shape in chronic MR but ellipsoid shape in acute MR and AR. Decreased LV size but normal shape was observed in mitral stenosis and cor pulmonale. In hypertrophic cardiomyopathy the LV wall was asymmetrically hypertrophied, while in congestive cardiomyopathy the wall is thin with marked LV dilatation and the shape was spherical. We concluded that the heart had characteristic configuration which might reflect cardiac performance or compensate for the load to the heart, and that thallium-201 myocardial scintigraphy is useful in the evaluation of cardiac morphology as well as in diagnosis of myocardial ischemia. (author).

  7. Experimental and clinical study of cardiac hypertrophy by thallium-201 myocardial scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Torii, Yukio (Kyoto Prefectural Univ. of Medicine (Japan))

    1983-09-01

    I studied experimentally the myocardial uptake of /sup 201/Tl in cardiac hypertrophy in rat, and clinically evaluated cardiac shape and dimension in the patients with various types of cardiac hypertrophy. Experimentally, both myocardial blood flow (MBF) and Tl uptake were increased with cardiac weight. There were negative correlations between the extraction fraction and MBF. Tl uptake in Hypertrophy is not always dependent on MBF and affected by the altered metabolism of hypertrophied myocardium. Clinical study was performed in 29 normal subjects and in 90 patients with heart disease. The measurements of left ventricular (LV) size by Tl scintigraphy were well correlated with them by echocardiography. Aortic stenosis and hypertensive heart disease showed thick wall and spherical shape. Both mitral (MR) and aortic (AR) regurgitation showed ventricular dilatation, spherical shape (in chronic MR) and ellipsoid shape (in acute MR and in AR). Decreased ventricular size but normal shape was observed in mitral stenosis and cor pulmonale. Hypertrophic cardiomyopathy showed thick wall with asymmetric septal hypertrophy, while congestive cardiomyopathy showed thin wall with marked ventricular dilatation and spherical shape. I conclude that heart disease has characteristic figures in dimension and shape which may be reflecting cardiac performance or compensating for the load to the heart, and that /sup 201/Tl scintigraphy is useful evaluating cardiac morphology as well as in diagnosing myocardial ischemia.

  8. Evaluation of myocarditis using Tl-201 myocardial scintigraphy with Bull's eye functional map

    Energy Technology Data Exchange (ETDEWEB)

    Satoh, Keiko; Utsumi, Jinji; Satoh, Hiroyuki (Juntendo Univ., Tokyo (Japan). School of Medicine) (and others)

    1991-04-01

    In order to evaluate myocardial damage in a patient with myocarditis, rest thallium-201 myocardial single photon emission computed tomography (SPECT) was performed in 15 patients with myocarditis. For qualitative and semiquantitative analysis, Bull's eye functional maps were made up with SPECT images. In the functional map, the abnormal area, where Tl uptake is less than mean-2SD of the Tl uptake of normal subjects, is generally distributed in the myocarditis group. But focal and sequential abnormal areas were recognized more often in the clinically severe cases. Abnormal area tended to be observed commonly at the antero-septal wall, but it was uncommon at the lateral wall. Extent score, i.e. degree of extension of abnormal area, and severity score, i. e. degree of abnormality, were in good negative correlation with left ventricular ejection fraction (r=0.6, r=0.7). Furthermore, existence of abnormal area was in good correlation with the left ventricular regional wall motion. Abnormal area existed 100% in the akinetic region , 71% in the region of severe hypokinesis, and 27% in the region of hypokinesis. Abnormal area occupied 30% of the normokinetic region in the myocarditis group, which was a higher rate than in the normal control group (p<0.05). It was suggested that latent myocardial damage existed in the normokinetic myocardium with myocarditis. Thus, rest Tl-201 SPECT with Bull's eye map is useful for clinical diagnosis in patients with myocarditis. (author).

  9. Evaluation of Tl-201 SPECT for monitoring the treatment of pulmonary and mediastinal tumors

    Energy Technology Data Exchange (ETDEWEB)

    Namba, Ryuichiro; Narabayashi, Isamu; Matsui, Ritsuo; Sueyoshi, Kozo; Nakata, Yasunobu; Tabuchi, Kojiro; Komori, Tsuyoshi [Osaka Medical Coll., Takatsuki (Japan)

    1995-05-01

    Tl-201 single photon emission computed tomography (SPECT) was performed in 88 patients with pulmonary or mediastinal tumors in order to evaluate its usefulness for the detection of disease and for the assessment of the effect of treatment. We also examined mediastinal and hilar lymph node metastasis from lung cancer. Tl-201 SPECT showed abnormal accumulation on delayed images in all lung cancer patients with tumor diameters more than 12 mm. In the 14 operated lung cancer patients, mediastinal and hilar lymph node metastases with diameters of more than 15 mm were imaged, but one with a diameter of 9 mm was missed. The retention index (RI) was 27.52{+-}31.58 in malignant tumors and -13.67{+-}8.15 in benign tumors (p<0.05). The RI was significantly lower after treatment than before treatment. The interval until tumor recurrence or reactivation tended to be longer in patients who showed a significant decrease in the RI after therapy. These findings suggest the usefulness of the RI as an index of therapeutic efficacy. (author).

  10. ABO blood group A antigen expression in A201 allele analysis of activity%ABO血型A201等位基因表达A抗原活性的分析

    Institute of Scientific and Technical Information of China (English)

    曾学平; 王恭; 陆理; 李涛; 冯学冠

    2014-01-01

    目的:研究ABO血型A201等位基因表达A抗原活性。方法运用血型血清学方法对1家2代3人的唾液及血液标本的ABO血型进行检测;运用Identifiler法医基因分析试剂盒作为亲缘关系鉴定;PCR扩增ABO基因后,对所有外显子做DNA测序分析,运用PCR-RFLP法进行同步检测A201等位基因中的序列变异。结果亲缘关系鉴定在Identifiler的15个遗传标记系统中显示,父母可以将所有的等位基因提供给子女,确定具有亲缘关系;然而运用不同来源的3份抗体对ABO血型进行检验时,却出现了正定型否定了母子关系,反定型无法排除母子关系的现象。3个标本ABO基因的测序:父、母、子的基因型分别为O01/O01、A201/B101及A201/O01,符合反定型结果,这就说明A201等位基因在A表型及AB表型中表达的A抗原活性差异显著。运用PCR-RFLP法可将A201等位基因中的2个主要变异点1059-1061delC和467C/T。结论 ABO血型A201基因在AB及A表型中表达A抗原活性,可由于检测抗体不同出现一定的差异;基因测序与PCR-RFLP法进行同步分析能够快速简便的鉴定A201等位基因中的1059-1061delC和467C/T。%Objective To study the ABO blood group A antigen expression in A201 allele activity. Methods Using serological methods, a two-generation three human saliva and blood samples were used to detect ABO blood. Forensic genetic analysis using Identifiler kit was used as kinship identification including PCR amplification ABO gene,exons do for all DNA sequencing,PCR-RFLP method using synchronous detection of sequence variation A201 allele. Results Identification of the genetic relationship of 15 genetic markers was performed using Identifiler system, which shows that parents can have all the alleles,be available to children determined to have kinship. However,after the use of three different sources of ABO blood group antibodies,they appeared the mother-child relationship was

  11. D201树脂对绿原酸的吸附、解吸性能研究%Adsorption and desorption of chlorogenic acid with macrorporous resin D201

    Institute of Scientific and Technical Information of China (English)

    赵升强; 欧仕益; 邱瑞霞

    2013-01-01

    为了从植物材料中分离、纯化绿原酸,研究了3种树脂对绿原酸的吸附和解吸特性,优选出了D201树脂,其最大吸附量为101.2mg/mL树脂,最低吸附浓度为0.6μg/mL在此基础上,详细研究了D201对绿原酸的解吸工艺:洗脱剂配比为无水乙醇∶水∶盐酸=50∶48∶2(V/V/V) 实验表明D201可用于提取纯化马铃薯洗液中绿原酸.%In order to separate and purify chlorogenic acid from plant materials, the adsorption and desorption capacity of three kinds of macroporous resins for chlorogenic acid had been investigated.lt was found that D201 was the best one, its adsorption capacity and adsorption equilibrium concentration for chlorogenic acid was 101.2mg/mL resin,and 0.6|jg/mL respectively.The desorption solution was composed of ethanol:water:HCI in ratio 50:48:2(v/v/v).Experiments showed chlorogenic acid could be well extracted and purified from potato washing water through D201 resin.

  12. 梅奇酵母XY201对冬枣采后病原真菌的抑制效果%Inhibitory Effect of Metschnikowia zizyphicola XY201 on Fungal Pathogens of Postharvest Jnjube Fruits

    Institute of Scientific and Technical Information of China (English)

    施俊凤; 薛梦林; 张晓宇; 王亮; 王春生

    2010-01-01

    本文对梅奇酵母 Metschnikowia ziryphicola XY201进行了生物量最大值培养时间、不同环境条件下的活力变化及其对冬枣采后病原真菌抑制效果的研究.结果表明,梅奇酵母 XY201菌株在NYDB培养基中培养96h后,菌体生物量达最大值3.84×100cfu/ml.XY201在20℃、4℃和0℃三个不同温度和不同介质条件下的生活力变化不同,0℃培养液菌体生活力最强,240d时菌液浓度为6.46×107cfu/ml.XY201能显著抑制冬枣采后病原菌扩展青霉 Penicillium expansum、细极链格孢 Altemaria alternata、黑曲霉 Aspergillus niger 和黑根霉Rhizopus nigricans的孢子萌发和菌丝伸长;当酵母菌浓度为5×10scfu/ml时,对病原菌的抑制率可达100%.对峙培养结果显示XY201对A.alternata生长的抑制率为42.59%.

  13. Rules implementing Sections 201 and 210 of the Public Utility Regulatory Policies Act of 1978: a regulatory history

    Energy Technology Data Exchange (ETDEWEB)

    Danziger, R.N.; Caples, P.W.; Huning, J.R.

    1980-09-15

    An analysis is made of the rules implementing Sections 201 and 210 of the Public Utility Regulatory Policies Act of 1978 (PURPA). The act provides that utilities must purchase power from qualifying producers of electricity at nondiscriminatory rates, and it exempts private generators from virtually all state and Federal utility regulations. Most of the analysis presented is taken from the perspective of photovoltaics (PV) and solar thermal electric point-focusing distributed receivers (pfdr). It is felt, however, that the analysis is applicable both to cogeneration and other emerging technologies. Chapters presented are: The FERC Response to Oral Comments on the Proposed Rules Implementing Sections 201 and 210 of PURPA; Additional Changes Made or Not Made That Were Addressed in Other Than Oral Testimony; View on the Proposed Rules Implementing Sections 201 and 210 of PURPA; Response to Comments on the Proposed 201 and 210 Rules; and Summary Analysis of the Environmental Assessment of the Rules. Pertinent reference material is provided in the Appendices, including the text of the rules. (MCW)

  14. 21 CFR 201.307 - Sodium phosphates; package size limitation, warnings, and directions for over-the-counter sale.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Sodium phosphates; package size limitation... Requirements for Specific Drug Products § 201.307 Sodium phosphates; package size limitation, warnings, and... and Drug Administration indicate that multiple container sizes of sodium phosphates oral...

  15. Use of thallium 201 myocardial imaging to exclude myocardial infarction after dissection in congenital coarctation of the aorta

    Energy Technology Data Exchange (ETDEWEB)

    Halon, D.A.; Weiss, A.T.; Tzivoni, D.; Atlan, H.; Gotsman, M.S.

    1981-10-01

    The use of a mobile gamma camera with thallium 201 myocardial imaging is described to exclude myocardial infarction in a patient admitted to the coronary care unit in shock and with clinical, enzyme, and ECG changes consistent with infarction. The patient suffered from acute aortic dissection associated with congenital coarctation of the aorta. The myocardial scan excluded transmural myocardial injury.

  16. 34 CFR 403.201 - What are the State's responsibilities for developing and implementing a statewide system of core...

    Science.gov (United States)

    2010-07-01

    ... and implementing a statewide system of core standards and measures of performance? 403.201 Section 403... a statewide system of core standards and measures of performance? (a)(1) Each State board receiving funds under the Act shall develop and implement a statewide system of core standards and measures...

  17. 7 CFR 201.29a - Germination of vegetable seed in containers of more than 1 pound.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Germination of vegetable seed in containers of more... AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Labeling Vegetable Seeds § 201.29a Germination of vegetable seed in containers of more than 1 pound. Each variety of vegetable seeds...

  18. Thallium-201 myocardial imaging in children with heart disease. Quantitative assessment of right ventricular pressure

    Energy Technology Data Exchange (ETDEWEB)

    Mitomori, Toshihiro; Ono, Yasuo; Kamiya, Tetsuro; Nishimura, Tsunehiko; Kozuka, Takahiro (National Cardiovascular Center, Suita, Osaka (Japan)); Kohata, Tohru; Tanimoto, Takeshi

    1985-02-01

    201-TlCl myocardial imaging studies were performed to evaluate systolic pressure of right ventricle on 107 patients including 89 patients with congenital cardiac disease, patients with primary pulmonary hypertension and 13 patients with history of MCLS with the age range of 2 months to 17 years. The congenital cardiac disease group included 30 patients with tetralogy of Fallot, 8 patients with pulmonary stenosis (included 1 patient with double chambered right ventricle), 20 patients with ventricular septal defect, 10 patients with patent ductus arteriosus, 9 patients with atrial septal defect and 12 patients with complete transposition of great arteries. None of the patients with history of MCLS had coronary involvement. 50 ..mu..Ci/kg of 201-TlCl was infused intravenously and after 15 minutes the images were obtained from 5 directions (anterior, LAO 30, LAO 45, LAO 60 and lateral). The angle was determined to demonstrate the intraventricular septum and ventricular free walls cleary separated. The image of end-diastolic phase was obtained with ECG synchronized gated method from that direction. The ROI (region of interest) was defined as a slice line by drawing two lines perpendicular to the septum and the counts of the left and right ventricular free wall (Cl and Cr) were analyzed to evaluate the pressure of right ventricle. The pressure of ventricles were obtained by cardiac catheterization performed at the same time with myocardial imaging. The ratio of Cl and Cr (Cr/Cl) had good correlation with the ratio of peak systolic pressure of left ventricle and right ventricle (regression equation Y=0.84X + 0.08, r=0.87). In each congenital heart disease group, very good correlation was also demonstrated (Y=1.46X - 0.30, r=0.96 in PS; Y=0.70X0.20, r=0.91 in VSD; Y=0.86X + 0.15, r=0.78 in ASD and Y=0.72X + 0.24, r=0.80 in PDA). Thus 201-TlCl myocardial imaging was useful method to evaluate right ventricular pressure noninvasively in congenital cardiac disease.

  19. Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies.

    Science.gov (United States)

    Moilanen, Anu-Maarit; Riikonen, Reetta; Oksala, Riikka; Ravanti, Laura; Aho, Eija; Wohlfahrt, Gerd; Nykänen, Pirjo S; Törmäkangas, Olli P; Palvimo, Jorma J; Kallio, Pekka J

    2015-07-03

    Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain the addiction. Known causes of CRPC include gene amplification and overexpression as well as point mutations of AR. We report here the pharmacological profile of ODM-201, a novel AR inhibitor that showed significant antitumor activity and a favorable safety profile in phase 1/2 studies in men with CRPC. ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509, inhibits testosterone-induced nuclear translocation of AR. Importantly, ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies, including the F876L mutation that confers resistance to enzalutamide and ARN-509. In addition, ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. In contrast to other antiandrogens, ODM-201 shows negligible brain penetrance and does not increase serum testosterone levels in mice. In conclusion, ODM-201 is a potent AR inhibitor that overcomes resistance to AR-targeted therapies by antagonizing both overexpressed and mutated ARs. ODM-201 is currently in a phase 3 trial in CRPC.

  20. Effect of Plasma Nitriding Temperatures on Characteristics of Aisi 201 Austenitic Stainless Steel

    Science.gov (United States)

    Gao, Yuxin; Zheng, Shaomei

    2016-10-01

    Samples of AISI 201 austenitic stainless steel were produced by plasma nitriding at 350∘C, 390∘C, 420∘C, 450∘C and 480∘C for 5h. Systematic characterization of the nitrided layer was carried out in terms of micrograph observations, phase identification, chemical composition depth profiling, surface microhardness measurements and electrochemical corrosion tests. The results show that the surface hardness and the layer thickness increased with increasing temperature. XRD indicated that a single S-phase layer was formed during low temperature (≤420∘C), while Cr2N or CrN phase was formed besides S-phase when nitrided at 450∘C and 480∘C. The specimen treated at 390∘C presents a much enhanced corrosion resistance compared to the untreated substrate. The corrosion resistance deteriorated for samples treated above 450∘C due to the formation of chromium nitrides.

  1. Routine limulus amoebocyte lysate (LAL) test for endotoxin determination in milk using a Toxinometer ET-201.

    Science.gov (United States)

    Mottar, J; De Block, J; Merchiers, M; Vantomme, K; Moermans, R

    1993-05-01

    A rapid method of performing the Limulus amoebocyte lysate (LAL) test in milk is proposed using the Toxinometer ET-201. This instrument measured the increase in turbidity due to the interaction between the endotoxins of the Gram-negative bacteria and the LAL reagent, monitored the ratio Rt of the sequential to the initial transmission at 12 s intervals and quantified endotoxins by determination of the reaction time Tr required to obtain a 5% decrease in Rt. There was a good correlation between the toxinometrically determined endotoxin concentrations and the number of Gram-negative bacteria (SD, 0.18 log(plate count units)), and the repeatability (CV, 6-10%) was high. The assay may be useful for screening raw materials for UHT milk production, as the endotoxin content of the raw material is related to the rest proteinase activity in the UHT milk.

  2. Study of Static Adsorption Capacity of ACF for Xenon at 201 K

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The static adsorption performances of a series of active carbon fiber (ACF)for xenon at 201 K were measured with a model ASAP2010M specific surface area and aperture distribution instrument by changing the working gas of instrument from N2 to Xenon. Compared with grain active carbon(GAC): (1) the adsorption performance of Viscose-based ACF(VACF) adsorbents is better than that of GAC; (2) owing to the difference of aperture distribution, the adsorption performance of ACF with different radicales is different under the same experiment conditions though the specific surface area is similar; (3) there is no definite relationship between adsorption performance and specific surface area; (4) the VACF-A2 is the superior xenon adsorbent at the experimental temperature.Keyworls Active carbon fiber, CTBT, Xenon, Static adsorption, Adsorptive capacity, Adsorptive velocity

  3. [Effect of wall thickness of left ventricle on 201Tl myocardial SPECT images: myocardial phantom study].

    Science.gov (United States)

    Koto, M; Namura, H; Kawase, O; Yamasaki, K; Kono, M

    1996-07-01

    201Tl myocardial SPECT is known for better sensitivity, specificity, and accuracy than planar images in detecting coronary artery disease and diagnosing myocardial viability. SPECT images are also superior to planar images in diagnostic sensitivity and anatomical orientation. However, as limitation of the spatial resolution of the machine, we often encounter poor SPECT plower image quality in patients with decreased wall thickness. To test the accuracy of SPECT images in patients with marked thinning of the left ventricular wall, as occurs in dilated cardiomyopathy, we performed a experimental study using myocardial phantom with 7 mm wall thickness. Tomographic image of the phantom images were rather heterogeneous, though no artificial defect was located. Dilated cardiomyopathy is thought to be characterized by patchy defects in the left ventricle. Careful attention should be given to elucidating myocardial perfusion in patients with a thin left ventricle wall, as there are technical limitations in addition to clinical features.

  4. Evaluation of non-circular orbit in thallium-201 myocardial SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Shinya; Meguro, Mitsuhiko; Takeishi, Yasuchika (Yamagata Univ. (Japan). School of Medicine) (and others)

    1991-09-01

    A non-circular orbit in thallium-201 myocardial SPECT was evaluated using phantom studies. Spatial resolution, data uniformity, and defect detectability were compared with those obtained by a circular orbit. Spatial resolution in the horizontal direction was better by a non-circular orbit than by a circular orbit; however, there was little or no improvement in the vertical direction. A non-circular orbit was a little inferior to a circular orbit for data uniformity in SPECT with 180deg data acquisition. It had higher ability to detect perfusion defects in the anterior, septal, and lateral walls, corresponding to the areas where spatial resolution was improved. There was no difference in posterior defect between non-circular and circular orbits. (N.K.).

  5. MICROSTRUCTURE AND PROPERTIES OF ZL201 ALLOY OBTAINED BY NEAR-LIQUIDUS ELECTROMAGNETIC CASTING

    Institute of Scientific and Technical Information of China (English)

    P. Wang; L.F. Sh; G.M. Lu; J.Z. Cui

    2005-01-01

    The microstructures of ZL201 alloy slurry prepared by near-liquidus electromagnetic casting(NLEMC), electromagnetic casting(EMC), and near-liquidus casting(NLC) were investigated by means of electron microscopy and image analysis. Mechanical properties of as-cast alloys were determined. The results show that the NLEMC induces a fine, uniform, and equiaxed grain structure with a mean equal-area-circle grain diameter of 32.8μm. The as-cast alloy has a hardness of HV122.8 and a tensile strength of 368MPa. Both of them are better than those of the alloys prepared by EMC and by NLC. The mechanism of grain refinement in the NLEMC alloy slurry was discussed.

  6. sup 201 Tl SPECT for evaluation of brain tumors as compared with sup 123 I-IMP SPECT and sup 18 F-FDG PET

    Energy Technology Data Exchange (ETDEWEB)

    Oriuchi, Noboru (Gunma Univ., Maebashi (Japan). School of Medicine)

    1991-01-01

    Clinical usefulness of {sup 201}Tl SPECT for evaluation of brain tumors was studied in comparison with {sup 123}I-IMP SPECT and {sup 18}F-FDG PET. {sup 201}Tl SPECT and {sup 123}IMP SPECT were performed in 73 patients with brain neoplasm (group 1) and 15 patients with non-tumor cerebral diseases (group 2). Among them, 31 patients in group 1 and 5 patients in group 2 received {sup 18}F-FDG PET. SPECT was done with a ring type machine (HEADTOME SET011) and PET with a neuro PET (PCT H1). Forty-eight of 73 (65.8%) patients in group 1 showed increased accumulation of {sup 201}Tl in tumor site, whereas only 9 (12.3%) patients showed increased radioactivity of {sup 123}I-IMP in the lesion. Eighteen of 31 (58.1%) patients with neoplasm demonstrated increased regional cerebral metabolic rate of glucose (rCMRgl) in the lesion. Only two out of 15 (13.3%) patients with non-tumor lesion demonstrated increased accumulation of {sup 201}Tl. None of them showed accumulation of {sup 123}I-IMP or increased rCMRgl. Patients with malignant neoplasm demonstrated higher uptake of {sup 201}Tl in the lesion than those with benign neoplasm or non-tumor lesions. Post-therapeutic patients with glioblastoma or metastatic tumors showed lower {sup 201}Tl uptake than before therapy. Superimposed images of both {sup 201}Tl and {sup 123}I-IMP resemble rCMRgl functional images, suggesting increased {sup 201}Tl radioactivity in viable tumor tissue with decreased radioactivity in surrounding areas. {sup 201}Tl SPECT is useful for diagnosis of brain tumors and evaluation of effectiveness of therapy or evidence of residual tumor tissue. It may differentiate malignant tumors from benign tumors or non-tumor intracranial diseases including radiation injury and detect tumor recurrence earlier. (author).

  7. Clinical investigation of large perfusion defect cases with {sup 201}Tl exercise myocardial scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Morota, Motoi; Kobayashi, Yasuhiko [Tokyo Medical Coll. (Japan)

    1999-02-01

    We investigated retrospectively the clinical significance of large perfusion defect on {sup 201}Thallium myocardial scintigraphy from the records of 833 patients during the past 3 years from 1991 to 1994. The patients were divided into 3 groups according to the extent of perfusion defect; cases with normal perfusion (n=561), with small perfusion defect (n=211) and with large perfusion defect (n=61). We found that the proportions of cases with large perfusion defect was significantly larger than that of cases with small perfusion defect in myocardial disease (MD; hypertrophic cardiomyopathy, dilated cardiomyopathy, and post myocarditis combined) (P<0.001). Analyzing patients with ischemic heart disease (IHD; angina pectoris and myocardial infarction) according to the severity of coronary artery lesion, the proportion of cases with large perfusion defect was significantly larger than that of cases with small perfusion defect in 3 vessel disease (P<0.001). Incidence of diabetes mellitus was significantly higher in patients with IHD than in those with MD in large perfusion defect group (P<0.01). As for symptoms in large perfusion defect group, the incidences of chest pain, chest oppression, and chest discomfort were significantly higher in patients with IHD than in those with MD (P<0.001), whereas the incidences of palpitation and shortness of breath were significantly higher in patients with MD (P<0.001). These results suggest that IHD with multiple artery lesions and MD underlie large perfusion defect on {sup 201}Thallium myocardial scintigraphy and that complication of diabetes mellitus and clinical symptoms may be useful in differentiating IHD from MD. (author)

  8. ACCUMULATION OF POLYHYDROXYALKANOIC ACIDS BY AZOTOBACTER CHROOCOCCUM MAL-201 FROM ORGANIC WASTE

    Directory of Open Access Journals (Sweden)

    Soma Pal Saha

    2013-08-01

    Full Text Available Azotobacter chroococcum MAL-201 (MTCC 3853, a free-living nitrogen-fixing bacterium accumulated intracellular poly(3-hydroxybutyric acid [P(3HB] accounting 69% of cell dry weight (CDW when grown in nitrogrn-free Stockdale medium containing 2% (w/v glucose. It also produced copolymer of poly(3-hydroxybutyrate co-3-hydroxyvalerate [P(3HB-co-3HV] using glucose as primary carbon source and valerate cas cosubstrate. To make the polymer production cost effective four types of waste material of different origin were tested for growth and polymer production. Stockdale medium supplemented with 1% (w/v waste materials failed to yield good growth and polymer accumulation. Two–step cultivation was adopted for better growth and enhanced polymer accumulation. The candy factory waste was most suitable for synthesis of P(3HB accounting 17.8 and 40.58% using single and two-step cultivation conditions respectively. Wastes of domestic and poultry origin produced P(3HB-co-3HV with 3HV content 28.8 and 21.5 mol% respectively in two-step cultivation. Increase concentration of these wastes resulted in further upliftment of 3HV content of polymer with reduced growth and polymer accumulation. However, at optimum incubation the strain MAL-201 cells accumulated P(3HB 48.5% of CDW (at 40h from candy factory waste and P(3HB-co-3HV 24.75 % of CDW with 3HV 34.65 mol % from domestic waste. Intrinsic viscosity, molecular weight and thermal degradation of the polymers accumulated in the cells grown in glucose, glucose with valerate and glucose with waste were compared.

  9. Evaluation of myocardial abnormalities in patients with collagen diseases by thallium-201 myocardial scintigram

    Energy Technology Data Exchange (ETDEWEB)

    Yamano, Shigeru (Nara Medical Univ., Kashihara (Japan))

    1992-08-01

    This study was performed to evaluate myocardial lesions in patients with collagen diseases by rest and exercise thallium-201 myocardial scintigraphies. A total of 76 patients without ischemic ECG changes, consisting of 27 cases of systemic lupus erythematosus (SLE), 17 cases of polymyositis or dermatomyositis (PM[center dot]DM), 11 cases of progressive systemic sclerosis (PSS), and 21 cases of Sjoegren's syndrome (SjS), were enrolled in this study. Reversible exercise-induced defects suggesting myocardial ischemia were noted in 12 cases of SLE, 5 cases of PM[center dot]DM, 3 cases of PSS, and 3 cases of SjS. Of the 23 patients who had exercise-induced defects, 9 patients showed normal coronary angiograms by cardiac catheterization. Fixed hypoperfusion areas were observed in 5 cases of SLE, 6 cases of PM[center dot]DM, 4 cases of PSS and 3 cases of SjS. Rest thallium-201 myocardial scintigraphy disclosed hypoperfusion areas, which were not induced by exercise, in 1 case of SLE, 4 cases of PM[center dot]DM, 1 case of PSS and 5 cases of SjS. Endomyocardial biopsy was performed on 20 patients. Myocardial lesions in PM[center dot]DM and PSS were more severe and wide spread than in SLE. Ejection fraction and fractional shortening evaluated by echocardiography had no significant differences between each disease group and the healthy control group. These findings suggest that patients with collagen diseases show the presence of abnormalities of coronary circulation at the level of the intramyocardial vasculature in the stage before impairment of cardiac function, myocardial fibrosis and functional abnormalities of the cell membrane level that were not dependent on myocardial ischemia. (author).

  10. Usefulness of thallium-201 myocardial perfusion scintigraphy in the diagnosis of chronic cor pulmonale

    Energy Technology Data Exchange (ETDEWEB)

    Kawai, S.; Tanaka, N.; Sawada, M.; Sakaguchi, K.; Fujita, K. (Osaka Prefectural Habikino Hospital, Osaka (Japan))

    1981-09-01

    To open up the possibility of exact clinical diagnoses of chronic cor pulmonale, we performed thallium-201 myocardial perfusion scintigraphy on patients with chronic pulmonary disease. From the thallium activity in the left ventricle (plus ventricular septum) and right ventricle counted scintigraphically, we determined the thallium activity ratio of left to right ventricle (TAR). The intra- and inter-observer variations of this ratio were negligible. We compared TAR with pulmonary hemodynamic findings and with left to right ventricular mass ratio measured at autopsy, and obtained the following results. 1) Left to right ventricular mass ratio determined in 11 autopsied patients by the method of Fulton et al. was closely correlated with TAR values (r = 0.90, p < 0.001). 2) In patients with chronic pulmonary disease, there were highly significant exponential inverse correlations between TAR and pulmonary arterial mean pressure, total pulmonary vascular resistance and right ventricular systolic pressure with the coefficients of -0.75, -0.72 or -0.77, respectively (p < 0.001). These results suggested the possibility that the severity of pulmonary circulatory disturbance may be ascertained non-invasively by TAR measurement. Thus, thallium-201 myocardial perfusion scintigraphy is able to reveal non-invasively right ventricular hypertrophy in patients with chronic pulmonary disease, and it might be a useful means of clinically diagnosing chronic cor pulmonale. If TAR obtained from scintigrams is smaller than 2, the patient concerned may possibly have right ventricular hypertrophy and he or she may be diagnosed as having chronic cor pulmonale.

  11. Quantitative evaluation of right ventricular overload in cor pulmonale using sup 201 Tl myocardial SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Hiroshi; Misawa, Toshihiro; Kutsumi, Yasunori (Fukui Medical School, Matsuoka (Japan)) (and others)

    1991-01-01

    To determine quantitatively the discriminant and characteristics of cor pulmonale, {sup 201}Tl myocardial perfusion SPECT was performed in 16 patients with chronic obstructive pulmonary disease (COPD) and 7 with restrictive pulmonary disease (RPD). One section of the short-axis SPECT image in which the right ventricle was most clearly visualized was selected. Tl-score was defined as the ratio of the sum of counts in the region of interest (ROI) at the anterior, mid, and posterior regions of the right ventricular free wall to the sum of counts in ROI at the posterior, lateral, and anterior walls of the left ventricle, and the anterior and posterior regions of the interventricular septum. In the group of COPD patients, Tl-score was positively correlated with mean pulmonary arterial pressure (mPAP), total pulmonary vascular resistance (TPR), and arterial carbon dioxide tension (PaCO{sub 2}), while it was inversely correlated with arterial oxygen tension (PaO{sub 2}). However, there was no significant correlation between Tl-score and mPAP, TPR, PaCO{sub 2}, and PaO{sub 2} in the group of RPD patients. In assessing pulmonary hypertension as defined by mPAP over 20 mmHg, a Tl-score greater than 0.25 was useful with a sensitivity of 69% and a specificity of 90%. The occurrence of cor pulmonale is a major factor in determining the prognosis of COPD patients. It was concluded that {sup 201}Tl myocardial SPECT is useful for evaluating right ventricular overload quantitatively, as well as for assessing core pulmonale, especially in COPD patients, since the ratio of Tl counts in the right and left ventricles was significantly correlated with right cardiopulmonary hemodynamic parameters. (N.K.).

  12. Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201 future therapy?

    Directory of Open Access Journals (Sweden)

    Dincer UD

    2012-04-01

    Full Text Available U Deniz DincerDepartment of Pharmacology, Ufuk University School of Medicine. Mevlana Bulvari, Balgat, Ankara, TurkeyAbstract: Metabolic syndrome is characterized by a combination of obesity, hypertension, insulin resistance, dyslipidemia, and impaired glucose tolerance. This multifaceted syndrome is often accompanied by a hyperdynamic circulatory state characterized by increased blood pressure, total blood volume, cardiac output, and metabolic tissue demand. Experimental, epidemiological, and clinical studies have demonstrated that patients with metabolic syndrome have significantly elevated cardiovascular morbidity and mortality rates. One of the main and frequent complications seen in metabolic syndrome is cardiovascular disease. The primary endpoints of cardiometabolic risk are coronary and peripheral arterial disease, myocardial infarction, congestive heart failure, arrhythmia, and stroke. Alterations in expression and/or functioning of several key proteins involved in regulating and maintaining ionic homeostasis can cause cardiac disturbances. One such group of proteins is known as ryanodine receptors (intracellular calcium release channels, which are the major channels through which Ca2+ ions leave the sarcoplasmic reticulum, leading to cardiac muscle contraction. The economic cost of metabolic syndrome and its associated complications has a significant effect on health care budgets. Improvements in body weight, blood lipid profile, and hyperglycemia can reduce cardiometabolic risk. However, constant hyperadrenergic stimulation still contributes to the burden of disease. Normalization of the hyperdynamic circulatory state with conventional therapies is the most reasonable therapeutic strategy to date. JTV519 (K201 is a newly developed 1,4-benzothiazepine drug with antiarrhythmic and cardioprotective properties. It appears to be very effective in not only preventing but also in reversing the characteristic myocardial changes and preventing

  13. COBAS S201核酸检测系统在献血者血液筛查中的应用%Use of COBAS S201 nucleic acid detection system in screening blood donors

    Institute of Scientific and Technical Information of China (English)

    车嘉琳; 黄志森; 王德文; 梁兵; 师玲玲; 许惠芯; 朱毅瑜

    2010-01-01

    目的 采用罗氏COBAS S201核酸检测系统,调查东莞市现行血液筛查系统的残余风险,以评估开展核酸检测(nucleic acid amplification technique,NAT)的必要性和可行性.方法 对2008年7月31日至2009年3月31日期间经ELISA检测阴性的40 018份献血者血液样本,采用罗氏COBAS S201检测系统进行HBV DNA,HCV RNA,HIV RNA检测.COBAS S201检测为阳性的献血者样本,分别采用COBAS Ampliprep/Taqman平台做核酸定量检测和罗氏ECL电化学发光检测系统作乙肝"两对半"实验,以帮助分析判定样本的感染状态.结果 发现31例核酸反应性样本,阳性率为0.77‰,其中有17例为HBV核酸反应性,残余风险为1/2354~1/1291,COBAS S201核酸检测系统的临床特异性为99.97%.结论 现行的血液筛查策略为两遍ELISA检测,但仍然存在输血传播疾病的风险.COBAS S201系统操作安全简便,包含罗氏专利技术的防污染技术,可确保检测结果准确可靠,适合于对献血者血液常规筛查.%Objective To investigate the residual risk in the current blood screening system in Dongguan City by Roche COBAS S201 nucleic acid detection system, in order to assess the necessity and feasibility of nucleic acid amplification technique (NAT). Methods 40 018 ELISA-negative samples were detected for HBV DNA, HCV RNA as well as HIV RNA by Roche COBAS S201 detection system from July 31,2008 to March 31, 2009. Positive samples were under quantitative detection of nucleic acid by COBAS Ampliprep/Taqman platform as well as "two pairs of semi "-experiments of hepatitis B by Roche ECL electrochemiluminescence detection system, aiming at helping to analyze the infection status of samples.Results 31 NAT-reactive samples were found, and the positive rate was 0.77‰. 17 of 31 samples were HBV DNA-reactive, and the residual risk was 1/2354-1/1291. The clinical specificity of COBAS S201 nucleic acid detection system was 99.97%. Conclusions The current blood screening strategy

  14. Study on Desalination of DA201-C Macroporous Adsorption Resin on Fermented Bean Curd Polypeptide%DA201-C大孔吸附树脂对腐乳多肽脱盐作用的研究

    Institute of Scientific and Technical Information of China (English)

    范文; 阮长青; 王鹤霖

    2011-01-01

    In order to remove the salt of fermented bean curd, benefit the separation and purification of active peptide and realize the target of the recovery rate of fermented bean curd polypeptides,the desalting technology of fermented bean curd polypeptides which were water - soluble after ultrafiltration by DA201 - C macroporous adsorption resin was investigated. The results indicated that the optimum condition for desalting was obtained as follows: loading sample concentration of 45 mg/mL,flow speed of 120 mL/h and 70% alcohol as eluent. Under these conditions,the ratio of fermented bean curd polypeptides desalination reached to 98. 19% , and the recovery of peptides was more than 90%. Moreover,its antioxidant activity was enhanced. In conclusion,the desalination method by using DA201 -C macroporous adsorption resin applied to fermented bean curd polypeptides was a simple and available method.%为去除腐乳中的盐分,利于其中活性肽的分离纯化,以腐乳多肽的回收率为指标,采用DA201-C大孔吸附树脂对超滤的水溶性低聚肽的脱盐工艺进行了研究.结果表明:DA201-C大孔吸附树脂对腐乳多肽较佳的脱盐工艺条件为上样浓度45 mg/mL、洗脱流速120 mL/h、解吸剂为70%乙醇.腐乳多肽经DA201-C大孔吸附树脂处理后脱盐率达到98.19%,肽回收率大于90%,抗氧化活性得到提高.利用DA201-C大孔吸附树脂是进行腐乳多肽脱盐处理的一种简便有效方法.

  15. Agreement of left ventricular ejection fraction and volumes between adenosine stress TL-201 gated SPECT and echocardiography

    Energy Technology Data Exchange (ETDEWEB)

    Pai, M. S. [College of Medicine, Univ. of Ewha, Seoul (Korea, Republic of); Moon, D. H.; Kim, H. M.; Yang, Y. J.; Kang, D. H. [Asan Medical Center, Seoul (Korea, Republic of)

    2003-07-01

    Electrocardiogram-gated TI-201 SPECT measurements of left ventricular ejection fraction (EF), end-diastolic volume (EDV), and end-systolic volume (ESV) have shown high correlation with conventional methods. However, how much these parameters measured by TI-201 gated SPECT differ from those by echocardiography has not been assessed. Adenosine stress (Ad-G) and redistribution TI-201 gated SPECT (Re-G) and resting echocardiography were conducted in 337 patients (184 male, 153 female). EDV, ESV and LVEF measured by QGS software were compared with the results by echocardiography. Patients with arrhythmia (atrial fibrillation or frequent premature contractions) or evidence of fixed or reversible perfusion defects on TI-201 SPECT were excluded. EF, EDV and ESV measured by Ad-G (63.3{+-}9.8,73.8{+-}30.2,29.1{+-}20.1) and Re-G (65.2{+-}11.6,69.1{+-}30.1,26.5{+-}20.3) correlated well with those by Echo (61.4{+-}7.9,78.3{+-}2.7, 30.7{+-} 17.5 ; r of Ad-G=0.547, 0.850, 0.827, p<0.001 ; r of Re-G=0.585, 0.838, 0.819, p<0.001). However the difference (mean, SD, SEE of Echo - gated SPECT) was statistically significant (EF: Ad-G=1.71, 8.92, 0.48, Re-G=3.59, 10.39, 0.56, p<0.001 ; EDV: Ad-G=4.75, 16.21, 0.88, Re-G=9.53, 16.77, 0.91, p<0.001 ; ESV: Ad-G=1.75, 11.35, 0.61, p<0.05, Re-G=4.29, 11.7, 0.63, p<0.001). Bland-Altman plots showed that the difference of EDV and ESV did not vary in any systematic way over the range of measurement, whereas the difference of EF increased with increasing average EF by Echo and gated-SPECT. The difference of EF, EDV, and ESV between Ad-G and Echo was significantly smaller than those between Re-G and Echo (p<0.001). Gated TI-201 SPECT underestimates EDV and ESV over a wide range of volume. As a result, EF by gated TI-201 SPECT is overestimated especially in patients with small LV volume. Ad-G is preferable to Re-G in assessing left ventricular ejection fraction and volume in place of Echo because of smaller bias.

  16. The characteristics of syndrome X based on {sup 201}Tl-SPECT, {sup 18} FDG-PET and histopathologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Satake, Osamichi [Kanazawa Medical Univ. (Japan)

    1999-03-01

    Syndrome X is a microvascular disease. However, the relationship between microvascular ischemia and histopathological findings remains unknown. The present study was performed to evaluate the myocardial perfusion and metabolism of patients with Syndrome X using {sup 201}Tl-SPECT and {sup 18}FDG-PET, and to clarify the morphological characteristics with a ventricular myocardial biopsy. We examined 24 patients with Syndrome X and 5 patients with myocarditis as a control group. In the study using {sup 201}Tl-SPECT and {sup 18}FDG-PET, we evaluated the presence or absence of myocardial ischemia. We calculated the Standardized Uptake Value (SUV) (%dose/ml) of {sup 18}FDG, and analyzed quantitatively the degree of ischemia. For histopathologic study on coronary microcirculation, we performed a right ventricular myocardial biopsy. The biopsies were examined light and electron microscopically. The semithin sections, stained with toluidine blue, were projected onto a screen. Microvessels were counted and the ratio of microvascular luminal narrowing and the number of microvessels per unit area were determined. The study using {sup 201}Tl-SPECT and {sup 18}FDG-PET showed that hypoperfusion of {sup 201}Tl was found in 17 of 24 (71%) patients during {sup 201}Tl-loaded myocardial scanning together with redistribution of {sup 201}Tl at the same regions; {sup 18}FDG-uptake were found in all 24 patients during {sup 18}FDG-PET performed under resting and fasting conditions; the SUV of {sup 18}FDG in the Syndrome X group (0.025{+-}0.039 %dose/ml) was significantly different from that of the control group (0.003{+-}0.002 %dose/ml) (p<0.01). Histopathological observations under the both light and electron microscope showed that an increment in number of the endothelial cells with swelling, a marked luminal narrowing due to the hypertrophy of the arteriolar media and the capillary walls, and a compression of the capillaries were shown in all the patients; the ratio of luminal narrowing

  17. Costeño-201: nueva variedad de sorgo de temporal de doble propósito para Sinaloa Costeño-201: a new variety of rianfed sorghum of dual purpose in Sinaloa

    Directory of Open Access Journals (Sweden)

    Luis Alberto Hernández Espinal

    2011-10-01

    Full Text Available La nueva variedad de sorgo Costeño-201, fue desarrollado en el Campo Experimental Valle de Culiacán (CEVACU del Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias (INIFAP, con número de registro SOG-200389-182 en el Catálogo de Variedades Factibles de Certificación (CVC de México. Esta variedad se adapta a las áreas productoras de sorgo para el estado de Sinaloa. Costeño-201 es una variedad de grano crema y se recomienda para condiciones de riego y temporal. El rendimiento promedio de la variedad es de 3 292 kg ha-1 de grano y 25 517 kg ha-1 de forraje verde, supera en rendimiento promedio de 8.8% y 12.4% respectivamente a híbridos comerciales de compañías privadas, que se cultivan en la región bajo las mismas condiciones. Costeño-201 tiene mejor calidad bromatológica que los híbridos comerciales en el forraje, con 9.5% de proteína y 64% de digestibilidad, supera en promedio 2.7% y 5% respectivamente a híbridos comerciales. Es tolerante a enfermedades que se presentan en la región, como son: ergot (Claviceps african, antracnosis (Colletotrichum graminícola, tizón de la panoja (Fusarium moniliforme y pudrición carbonosa del tallo (Macrophomina phaseolina. El forraje de sorgo Costeño-201, se recomienda como un material de doble propósito en prácticas de conservación del forraje como henificado y ensilaje.The new sorghum variety Costeño-201 was developed in the Experimental Field Culiacan (CEVACU of the National Research Institute for Forestry, Agriculture and Livestock (INIFAP, with the registration number SOG-200389-182 in the Catalog of Feasible Certification Varieties (CVC of Mexico. This variety is adapted to the sorghum-producing areas of Sinaloa State. Costeño-201, is a cream-grain variety and is recommended for irrigated and rainfed conditions. The average yield of the variety is 3 292 kg ha-1 grain and 25 517 kg ha-1 of green fodder, it outperforms on average of 8.8% and 12.4% respectively

  18. Assessment of myocardial perfusion and viability with technetium-99m methoxyisobutylisonitrile and thallium-201 rest redistribution in chronic coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Rosetti, C. [INB-CNR, University of Milan, Institute H San Raffaele (Italy); Landoni, C. [INB-CNR, University of Milan, Institute H San Raffaele (Italy); Lucignani, G. [INB-CNR, University of Milan, Institute H San Raffaele (Italy); Huang, G. [INB-CNR, University of Milan, Institute H San Raffaele (Italy); Bartorelli, A.L. [Institute of Cardiology, University of Milan, CNR, `I. Monzino` Foundation (Italy); Guazzi, M.D. [Institute of Cardiology, University of Milan, CNR, `I. Monzino` Foundation (Italy); Margonato, A. [INB-CNR, University of Milan, Institute H San Raffaele (Italy); Chierchia, S. [INB-CNR, University of Milan, Institute H San Raffaele (Italy); Galli, L. [INB-CNR, University of Milan, Institute H San Raffaele (Italy); Savi, A. [INB-CNR, University of Milan, Institute H San Raffaele (Italy); Fazio, F. [INB-CNR, University of Milan, Institute H San Raffaele (Italy)

    1995-11-01

    We compare thallium-201 rest redistribution and fluorine-18 fluorodeoxyglucose ([{sup 18}F]FDG) for the assessment of myocardial viability within technetium-99m methoxyisobutylisonitrile (MIBI) perfusion defects in 27 patients with chronic stable coronary artery disease. The following studies were performed: (1) stress {sup 99m}Tc-MIBI, (2) rest {sup 99m}Tc-MIBI, (3) {sup 201}Tl rest-redistribution single-photon emission tomography, (4) [{sup 18}F]FDG positron emission tomography. The left ventricle was devided into 11 segments on matched tomographic images. The segment with the highest activity at stress was taken as the reference (activity = 100%). Perfusion defects at {sup 99m}Tc-MIBI rest were classified as severe (activity < 50%), moderate (activity 50%-60%) or mild (activity 60%-85%). Uptakes of [{sup 18}F]FDG and rest-redistributed {sup 201}Tl were recognized as significant if they exceeded 50% of that in the reference segment. Among the 33 segments with severe {sup 99m}Tc-MIBI rest perfusion defects, 21 had significant [{sup 18}F]FDG and 10 significant rest-redistributed {sup 201}Tl uptake. As regards the 37 segments with moderate defects, [{sup 18}F]FDG was present in 29 and {sup 201}Tl in 31, while of the 134 segments with mild defects, 128 showed [{sup 18}F]FDG uptake, and 131, {sup 201}Tl uptake. In conclusion, there is an inverse relationship between the severity of {sup 99m}Tc-MIBI perfusion defects and the uptake of rest-redistributed {sup 201}Tl and [{sup 18}F]FDG. Both tracers are adequate markers of viability in mild and moderate defects; in severe defects {sup 201}Tl might underestimate the presence of viability as assessed by [{sup 18}F]FDG. (orig.)

  19. Noninvasive cardiac risk stratification of diabetic and nondiabetic uremic renal allograft candidates using dipyridamole-thallium-201 imaging and radionuclide ventriculography

    Energy Technology Data Exchange (ETDEWEB)

    Brown, K.A.; Rimmer, J.; Haisch, C. (Univ. of Vermont College of Medicine, Burlington (USA))

    1989-11-01

    The ability of noninvasive risk stratification using dipyridamole-thallium-201 (Tl-201) imaging and radionuclide ventriculography to predict perioperative and long-term cardiac events (myocardial infarction or cardiac death) was evaluated in 36 uremic diabetic and 29 nondiabetic candidates for renal allograft surgery. Of the 35 patients who underwent renal allograft surgery 8 +/- 7 months after the study, none had transient Tl-201 defects (although 13 had depressed left ventricular ejection fraction) and none developed perioperative cardiac events. During a mean follow-up of 23 +/- 11 months, 6 (9%) patients developed cardiac events. Logistic regression analysis was used to compare the predictive value of clinical data (including age, sex, diabetes, chest pain history, allograft recipient) and radionuclide data. Presence of transient Tl-201 defect and left ventricular ejection fraction were the only significant predictors of future cardiac events (p less than 0.01). No other patient variables, including diabetes or receiving a renal allograft, had either univariate or multivariate predictive value. All 3 patients with transient Tl-201 defects had cardiac events compared with only 3 of 62 (5%) patients without transient Tl-201 defect (p less than 0.0001). Mean left ventricular ejection fraction was lower in patients with cardiac events (44 +/- 13%) compared with patients without cardiac events (57 +/- 9%, p less than 0.005). Overall, 5 of 6 patients with cardiac events had either transient Tl-201 defects or depressed left ventricular ejection fraction. Dipyridamole-Tl-201 imaging and radionuclide ventriculography may be helpful in identifying uremic candidates for renal allograft surgery who are at low risk for perioperative and long-term cardiac events.

  20. Septal myocardial perfusion imaging with thallium-201 in the diagnosis of proximal left anterior descending coronary artery disease

    Energy Technology Data Exchange (ETDEWEB)

    Pichard, A.D.; Wiener, I.; Martinez, E.; Horowitz, S.; Patterson, R.; Meller, J.; Goldsmith, S.J.; Gorlin, R.; Herman, M.V.

    1981-07-01

    The use of myocardial perfusion imaging (MPI) to identify obstructive coronary disease of the left anterior descending coronary artery proximal to the first septal perforator (prox LAD) was studied in 60 patients. Perfusion of the septum and anteroapical areas with thallium-201 injected during exercise was compared to results of coronary arteriography. Septal MPI defect was found in 92.3% of patients with obstruction of the proximal LAD, 27.7% of patients with obstruction of LAD distal to first septal perforator, 0% in patients with obstructions involving right or circumflex arteries, and in 10.5% of patients without coronary disease. Anteroapical MPI defects were found with similar frequency in the three groups with obstructive coronary disease. Septal MPI defect had a sensitivity of 92.3% and specificity of 85.4% in the diagnosis of proximal LAD disease. Normal septal perfusion with thallium-201 virtually excluded proximal LAD disease.

  1. Evaluation of dilated cardiomyopathy by /sup 201/Tl myocardial single photon emission computed tomography. Morphological and quantitative analysis

    Energy Technology Data Exchange (ETDEWEB)

    Futagami, Yasuo; Makino, Katsutoshi; Ichikawa, Takehiko

    1984-08-01

    To estimate dilated cardiomyopathy (DCM)morphologically and quantitatively, /sup 201/Tl myocardial single photon emission computed tomography (SPECT) was performed in 14 DCM and 5 normal cases. Using a rotating dual-gamma camera system, resting SPECT data were collected for 6 minutes. Quantitative analysis of clinical cases was based on phantom studies. Marked spherical left ventricular (LV) dilatation (14/14), localized-diffuse low uptake or defect (12/14), and right ventricular visualization (6/14) were characteristic features in DCM. Differentiation of DCM from ischemic heart disease by SPECT was possible through the feature indicating disproportionately large LV cavity to defect size or degree. Quantitative analysis When DCM was compared with normal control (n-5), following 3 features were impressive: DCM was significantly higher in LV myocardial /sup 201/Tl uptake ratio and LV volume than normal control; DCM was significantly lower in LV myocardial /sup 201/Tl uptake ratio of unit volume (1 ml) than normal control; DCM was significantly lower in mean myocardial count/mean lung count.ratio than normal control.

  2. Optimization of Cultural Conditions for Production of Extracellular Polymeric Substances (EPS by Serpentine Rhizobacterium Cupriavidus pauculus KPS 201

    Directory of Open Access Journals (Sweden)

    Arundhati Pal

    2013-01-01

    Full Text Available Extracellular polymeric substances (EPS are complex biopolymers produced by a wide array of microorganisms for protection against dessication, aggregation, adhesion, and expression of virulence. Growth associated production of EPS by Ni-resistant Cupriavidus pauculus KPS 201 was determined in batch culture using sodium gluconate as the sole carbon source. The optimum pH and temperature for EPS production were 6.5 and 25°C, respectively. Optimal EPS yield (118 μg/mL was attained at 0.35% Na-gluconate after 72 h of growth. Cupriavidus KPS 201 cells also utilized glutamate, acetate, pyruvate, fumarate, malate, malonate, formate, citrate, and succinate for EPS production. Although EPS production was positively influenced by the increase of nitrogen and phosphate in the growth medium, it was negatively influenced by nickel ions. Compositional analysis of the purified EPS showed that it is a homopolymer of rhamnose containing uronic acid, protein, and nucleic acid. Presence of lipids was also detected with spectroscopy. Non-destructive EPS mediated biofilm formation of KPS 201 was also visualized by epifluorescence microscopy.

  3. The libRadtran software package for radiative transfer calculations (version 2.0.1)

    Science.gov (United States)

    Emde, Claudia; Buras-Schnell, Robert; Kylling, Arve; Mayer, Bernhard; Gasteiger, Josef; Hamann, Ulrich; Kylling, Jonas; Richter, Bettina; Pause, Christian; Dowling, Timothy; Bugliaro, Luca

    2016-05-01

    libRadtran is a widely used software package for radiative transfer calculations. It allows one to compute (polarized) radiances, irradiance, and actinic fluxes in the solar and thermal spectral regions. libRadtran has been used for various applications, including remote sensing of clouds, aerosols and trace gases in the Earth's atmosphere, climate studies, e.g., for the calculation of radiative forcing due to different atmospheric components, for UV forecasting, the calculation of photolysis frequencies, and for remote sensing of other planets in our solar system. The package has been described in Mayer and Kylling (2005). Since then several new features have been included, for example polarization, Raman scattering, a new molecular gas absorption parameterization, and several new parameterizations of cloud and aerosol optical properties. Furthermore, a graphical user interface is now available, which greatly simplifies the usage of the model, especially for new users. This paper gives an overview of libRadtran version 2.0.1 with a focus on new features. Applications including these new features are provided as examples of use. A complete description of libRadtran and all its input options is given in the user manual included in the libRadtran software package, which is freely available at http://www.libradtran.org.

  4. N-13 ammonia myocardial positron computed tomography, (1). Comparative study with thallium-201 SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Tamaki, Nagara; Senda, Michio; Yonekura, Yoshiharu

    1985-02-01

    Myocardial positron computed tomography (PCT) was obtained in 11 cases and the images were compared with thallium-201 single-photon emission computed tomography (SPECT). The myocardial PCT was performed at rest after 10-20 mCi of N-13 labeled ammonia injection using whole-body multislice PCT device (Positologica III). The PCT clearly delineated 2.5-3.0 mm hot spots while the SPECT barely showed 5.0 mm hot spots of Derenzo phantom. The myocardial images looked better in PCT because of the better spatial resolution and count statistics. The myocardium looked thinner and the papillary muscle was visualized by PCT. The PCT also showed the right ventricle in each case. Furthermore, PCT detected increased lung uptake of ammonia in 2 of the 8 cases with myocardial infarction, suggesting presence of pulmonary congestion. Perfusion defect was clearly seen by PCT as well as SPECT. However, the cardiac short-axis and long-axis sections which were easily obtained by SPECT were useful for the localization of the lesion. We conclude that both PCT and SPECT were valuable for the assessment of coronary artery disease. (author).

  5. Bulge RR Lyrae stars in the VVV tile $\\textit{b201}$

    CERN Document Server

    Gran, F; Saito, R K; Navarrete, C; Dékány, I; McDonald, I; Ramos, R Contreras; Catelan, M

    2015-01-01

    The VISTA Variables in the V\\'ia L\\'actea (VVV) Survey is one of the six ESO public surveys currently ongoing at the VISTA telescope on Cerro Paranal, Chile. VVV uses near-IR ($ZYJHK_{\\rm s}$) filters that at present provide photometry to a depth of $K_{\\rm s} \\sim 17.0$ mag in up to 36 epochs spanning over four years, and aim at discovering more than 10$^6$ variable sources as well as trace the structure of the Galactic bulge and part of the southern disk. A variability search was performed to find RR Lyrae variable stars. The low stellar density of the VVV tile $\\textit{b201}$, which is centered at ($\\ell, b$) $\\sim$ ($-9^\\circ, -9^\\circ$), makes it suitable to search for variable stars. Previous studies have identified some RR Lyrae stars using optical bands that served to test our search procedure. The main goal is to measure the reddening, interstellar extinction, and distances of the RR Lyrae stars and to study their distribution on the Milky Way bulge. A total of 1.5 sq deg were analyzed, and we found ...

  6. LX201获快速通道审批地位

    Institute of Scientific and Technical Information of China (English)

    钱苏宁(摘)

    2008-01-01

    美国FDA授予LuxBiosciences公司用于预防角膜移植排斥的LX201(I)快速通道审批地位。该产品是置于眼睑下方的眼内植入物,它将在一年内稳定地向眼内释放环孢素A(ciclosporinA)(Ⅱ)(已经用于预防肾以及其它实体器官移植的排斥)。(I)的两项重要的为期一年的Ⅲ期临床试验是LUCIDA项目的一部分,目前正在进行中。第一项试验在175例免疫排斥高危的患者中进行,以免疫排斥和移植物丧失为主要终点。第二项试验涉及240例在角膜移植后经历了排斥事件的受试者,以移植后52周内免疫性的移植物排斥事件或移植失败为主要终点。

  7. Assessment by dipyridamole-thallium-201 myocardial scintigraphy of coronary risk before peripheral vascular surgery

    Energy Technology Data Exchange (ETDEWEB)

    Sachs, R.N.; Tellier, P.; Larmignat, P.; Azorin, J.; Fischbein, L.; Beaudet, B.; Cadilhac, P.; Cupa, M.; De Saint Florent, G.; Vulpillat, M.

    1988-05-01

    From October 1983 to January 1985, 46 patients (38 men and 8 women; average age, 60 years; range, 37 to 83 years) underwent peripheral vascular surgery of either the internal carotid artery or the arteries of the lower limbs. Each patient had a thorough clinical examination, an ECG, and a dipyridamole-thallium-201 myocardial scan before operation. On the basis of results, they were divided into two groups: 20 patients with and 26 patients without chronic ischemic heart disease. Three major cardiac events were noted during or after a period of 1 month after surgery: There were two deaths due to cardiac ischemic events and one patient had postoperative unstable angina pectoris. These three patients were classified in the coronary group (NS). When the patients were classified on the basis of whether or not there was thallium redistribution on serial images after infusion of dipyridamole, 14 with redistribution and 32 without redistribution were noted. The three patients who had major cardiac events were in the former group (p less than 0.04). Our data suggest that patients in whom redistribution occurs have a high incidence of postoperative ischemic events. These patients should be considered for particular preoperative coronary care to avoid major postoperative cardiac events and to increase chances of survival.

  8. The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201-995 in patients with prolactinomas and acromegaly.

    Science.gov (United States)

    Lamberts, S W; Zweens, M; Klijn, J G; van Vroonhoven, C C; Stefanko, S Z; Del Pozo, E

    1986-08-01

    The somatostatin analogue SMS 201-995 has recently been shown to be effective in suppressing GH secretion in most acromegalic patients. In the present study it was investigated whether PRL release in prolactinoma and acromegalic patients might also be sensitive to SMS 201-995 and whether co-secretion of PRL in acromegaly plays a role in determining the sensitivity of GH secretion to SMS 201-995. The s.c. administration of 50 micrograms SMS 201-995 did not affect high plasma PRL levels in four microprolactinoma patients. Therapy of one of these patients for 3 d with 50 micrograms three times a day also did not affect PRL levels. The single administration of 50 micrograms SMS 201-995 in 22 acromegalic patients lowered plasma GH levels for 2-6 h to less than 5 micrograms/l in 14 patients and to less than 50% of control values in 16 patients. In 18 of these 22 patients the immunohistochemical picture of the pituitary tumour was known. Eleven patients had pure GH-containing tumours and in seven patients there were mixed GH/PRL-containing tumours. In two of these latter patients there was evidence for GH and PRL being secreted by the same tumour cells. The sensitivity of GH secretion to SMS 201-995 did not differ between the patients with pure GH or mixed GH/PRL-containing adenomas. Plasma PRL levels were not affected by SMS 201-995 in the patients with pure GH-secreting tumours, but were significantly suppressed in four of the seven patients with mixed GH/PRL containing tumours. Chronic treatment for 16 weeks of one patient with a mixed GH/PRL-containing tumour with SMS 201-995 (100 micrograms three times a day) resulted in normalization of both the increased GH and PRL levels. It is concluded that SMS 201-995 does not affect tumorous PRL secretion in patients with pure prolactinomas. In acromegalic patients with mixed GH/PRL-containing tumours PRL secretion in some patients is sensitive to SMS 201-995, making these patients good candidates for chronic treatment with

  9. Effect of the hemoglobin-based oxygen carrier HBOC-201 on laboratory instrumentation: cobas integra, chiron blood gas analyzer 840, Sysmex SE-9000 and BCT.

    Science.gov (United States)

    Wolthuis, A; Peek, D; Scholten, R; Moreira, P; Gawryl, M; Clark, T; Westerhuis, L

    1999-01-01

    As part of a clinical trial, we evaluated the effects of the hemoglobin-based oxygen-carrier (HBOC) HBOC-201 (an ultrapurified, stroma-free bovine hemoglobin product, Biopure, Cambridge, MA, USA) on our routine clinical chemistry analyzer (Cobas Integra, F. Hoffmann-La Roche Ltd, Basel, Switzerland ), blood gas analyzer (Chiron 840, Chiron Diagnostics Corporation, East Walpole, MA, USA), routine hemocytometry analyzer (Sysmex SE-9000, TOA Medical Electronics Co Ltd., Kobe, Japan), hemostasis analyzer (BCT, Dade-Behring, Marburg, Germany) and bloodbanking system (Dia-Med-ID Micro Typing System, DiaMed AG, Cressier, Switzerland). The maximum tested concentration of HBOC-201 was 65 g/l. Of the 27 routine clinical chemistry tests challenged with HBOC-201, bilirubin-direct, creatine kinase MB-fraction (CK-MB), creatine kinase (CK), gamma-glutamyltransferase (GGT), magnesium and uric acid were influenced by even low concentrations of HBOC-201. These tests were excluded from use on the plasma of patients treated with HBOC-201. Since the non-availability of the cardiac marker CK-MB may lead to problems in acute situations, we introduced the qualitative Trop T-test (Boehringer Mannheim), which was not influenced. The applicability of another nine tests was limited by the concentration of the HBOC-201 in the patients' plasma. No interference of HBOC-201 in routine hemocytometry, hemostasis-analysis and red-blood cell agglutination detection (blood-bank tests) was observed. Although immediate patient-care was not compromised, routine use of hemoglobin-based oxygen carriers will have a strong impact on logistical management. The development of robust laboratory tests free from the interference of the pigmented oxygen carriers should therefore precede its introduction into routine transfusion medicine.

  10. Similar oxygen cost of myocardial contractility between DPI 201-106 and epinephrine despite different subcellular mechanisms of action in dog hearts.

    Science.gov (United States)

    Futaki, S; Goto, Y; Ohgoshi, Y; Yaku, H; Suga, H

    1992-01-01

    The effects of DPI 201-106 (a novel, cyclic AMP-independent positive inotropic agent with Ca(2+)-sensitizing and Na(+)-channel agonistic mechanisms) on myocardial mechanics and energetics were assessed in the excised cross-circulated dog left ventricle. In the first protocol, the relation between left ventricular oxygen consumption (VO2) and systolic pressure-volume area (PVA) was analyzed before and during administration of DPI 201-106. The reciprocal of the slope of the VO2-PVA relation has been shown to reflect the contractile efficiency, and the VO2-intercept consists of the oxygen cost of contractility-dependent excitation-contraction coupling and basal metabolism. DPI 201-106 increased Emax (contractility index) and elevated the VO2-PVA relation in a parallel manner, i.e., the VO2-intercept increased without a change in the slope. In the second protocol, the increase in the VO2-intercept of the VO2-PVA relation for a unit increase in Emax (i.e., oxygen cost of enhanced contractility) was compared between DPI 201-106 and epinephrine in a paired manner in each heart. Epinephrine significantly abbreviated the time to end systole, whereas DPI 201-106 did not, suggesting that the mechanism of inotropic action differed between the two drugs. However, the oxygen cost of enhanced contractility was the same between the two drugs in each heart. Therefore, DPI 201-106 did not alter the contractile efficiency nor spare the oxygen cost of enhanced contractility as compared to epinephrine under the present experimental conditions. This suggests that the Ca(2+)-sensitizing effect of DPI 201-106, if any, is too small to spare the oxygen cost of contractility in the blood-perfused, non-failing dog heart.

  11. Diagnostic capabilities of I-131, TI-201, and Tc-99m-MIBI scintigraphy for metastatic differentiated thyroid carcinoma after total thyroidectomy.

    Directory of Open Access Journals (Sweden)

    Fujie,Shunji

    2005-06-01

    Full Text Available

    We investigated the diagnostic capabilities of I-131, Tl-201, and Tc-99m-MIBI (hexakis-2-methoxyisobutyl- isonitrile scintigraphy for thyroid cancer metastases after total thyroidectomy over the entire body and for every locus before and after thyroid bed ablation. After total thyroidectomy of thyroid cancer, 36 cases were subjected to I-131 treatment 64 times. They consisted of 17 men and 19 women with 31 papillary carcinomas and 5 follicular carcinomas. Their ages were 22--75(an average of 60.5+/-12.3 years. I-131 scintigraphy(I-131, Tl-201 scintigraphy(Tl-201, and Tc-99m- MIBI scintigraphy (Tc-99m-MIBI were performed. We defined the metastases as those cases in which serum thyroglobulin (Tgincreased significantly or in which we were able to prove the lesions on CT (computed tomography, MRI (magnetic resonance imaging or bone scintigram. Three radiology medical specialists visually evaluated each scintigram and calculated the sensitivity, specificity, and likelihood ratio. For whole-body sensitivity, both Tl-201 and Tc-99m-MIBI were high before ablation and I-131 was high after ablation. Before ablation, the negative likelihood ratio was less than 0.1 for Tl-201 and Tc-99m-MIBI, while the positive likelihood ratio was more than 10 for Tl-201. After ablation, the positive likelihood ratio for I-131, Tl-201, and Tc-99m-MIBI was more than 10. The sensitivity of the mediastinum was appropriate, except for I-131 before ablation, and the sensitivity of the lung before and after ablation was inferior for either tracer. The specificity of the cervix for I-131 before ablation was markedly deteriorated, but it increased after ablation.

  12. Evaluation of coronary artery disease using myocardial thallium-201 imaging with single photon emission computed tomography during adenosine induced coronary vasodilation

    Energy Technology Data Exchange (ETDEWEB)

    Abe, Shinya; Takeishi, Yasuchika; Chiba, Junya; Tonooka, Ichiro; Tomoike, Hitonobu (Yamagata Univ. (Japan). School of Medicine)

    1993-02-01

    Adenosine-loaded Tl-201 myocardial SPECT was performed in consecutive 55 patients with suspected ischemic heart disease. Among these patients, 22 had cuncurrently exercise Tl-201 myocardial SPECT imaging for comparison. Adenosine was intravenously injected at a dose of 0.14 mg/kg/min continuously for 6 min, and 3 min after the stard of injection Tl-201 was injected via the different vein. Myocardial SPECT images were acquired at 5 min and 3 hr after the completion of intravenous injection of adenosine. Perfusion defect and the presence or absence of redistribution (RD) were visually interpreted from the short- and long-axial tomograms. Relative Tl-201 regional uptake ratios were quantitatively determined. Decreased systolic arterial pressure, increased heart rate, and slightly increased rate-pressure product were observed with adenosine injection. Chest pain (13 patients), head-ache (7), ST depression (17), and A-V block II were also seen; however, these symptoms rapidly disappeared with the withdrawal of adenosine. The findings by adenosine loading were concordent with those by exercise loading (91% for perfusion defect and 86% for presence or absence of RD). According to segments, both loading tests were concordent in 90% for persusion and 89% for RD. Both adenosine- and exercise-loaded imagings correlated well with regional Tl uptake by segements, the lowest value of Tl-201 defect, and extent score of Tl-201 defect. Adenosine-loaded imaging had a sensitivity of 100%, a specificity of 88%, and an accuracy of 97% for detecting parenchymal coronary lesions in evaluable 39 patients. In evaluable 22 patients, the sensitivity, specificity, and accuracy were 100%, 83%, and 95% for adenosine-loaded imaging and 88%, 83%, and 86% for exercise-loaded imaging. Thus, adenosine-loaded Tl-201 myocardial SPECT may be a safety and useful method for diagnosing ischemic heart disease. (N.K.).

  13. Lung uptake of thallium-201 on resting myocardial imaging in assessment of pulmonary edema

    Energy Technology Data Exchange (ETDEWEB)

    Tamaki, N.; Yonekura, Y.; Yamamoto, K. (Kyoto Univ. (Japan). Hospital)

    1981-03-01

    We have noted increased lung uptake of thallium-201 on resting myocardial images in patients with congestive heart failure. To evaluate this phenomenon, lung uptake of thallium on resting myocardial imaging was examined in 328 patients with various cardiovascular diseases. Increased lung uptake was observed in 117 cases (78%) with myocardial infarction, 32 (37%) with angina pectoris, 6 (27%) with hypertensive heart disease, 7 (30%) with hypertrophic cardiomyopathy, 6 (100%) with congestive cardiomyopathy, 11 (100%) with valvular heart disease, and 7 (71%) with congenital heart disease, however, only one (5%) of normal subjects revealed increased uptake. Left ventricular ejection fraction was evaluated in 32 cases with ischemic heart disease on the same day and it was significantly decreased as the lung uptake of thallium increased. Increased thallium activity in the lung seemed to be another noninvasive marker of lift heart failure in ischemic heart disease. Lung uptake of thallium was compared with pulmonary congestive signs on chest X-ray in 29 cases. The uptake was well correlated with the degree of pulmonary edema, and thallium myocardial image revealed remarkably increased lung uptake in all the patients accompanied with pulmonary interstitial edema on chest X-ray. Therefore, this phenomenon will demonstrate pulmonary edema, since thallium may be extracted to the increased interstitial distribution space of the lung as well as the myocardium in a patient with pulmonary edema. We conclude that thallium myocardial scintigraphy is useful not only in identification and localization of myocardial ischemia or infarction, but also in evaluation of pulmonary edema at the same time.

  14. {sup 201}Thallium SPECT, accuracy in astrocytoma diagnosis and treatment evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kaellen, K

    1999-10-01

    The aims of the studies included in this thesis were: - to investigate the reliability of {sup 201}Thallium single photon emission computed tomography. Tl SPECT for preoperative diagnosis and histological staging of malignant astrocytomas in comparison with CT; - to develop a method for quantification of cerebral thallium uptake, and to evaluate the quantitative measurement in comparison with CT, for astrocytoma treatment follow-up purposes; - to compare quantitative Tl SPECT and proton magnetic resonance spectroscopy (H-MRS) with conventional MR imagingfor astrocytoma monitoring, and to evaluate associations between change of morphological tumour characteristics during treatment and changes of cerebral thallium uptake and metabolic ratios. Results and conclusions: - High TI-index, calculated as a ratio comparing tumour uptake to uptake in the contralateral hemisphere, is an indicator of highly malignant astrocytoma. Differentiation between the high-grade astrocytomas, the low-grade astrocytomas, and infectious lesions is only partial, with an overlap of Tl-indexes between these groups. High-grade astrocytomas that do not show contrast enhancement on CT, and astrocytomas with central necrosis and moderate ring-enhancement, tend to be underestimated when evaluated by Tl-index calculation. Tl SPECT is not a reliable method for non-invasive tumour staging among the group of highly malignant astrocytomas. - Quantification of cerebral TI-uptake, defining the volume of viable tumour tissue, is a new method for astrocytoma chemotherapy monitoring. Results suggest that the method provides prognostic information, and information of treatment efficacy, at an earlier stage than CT. - We did not find a higher accuracy of quantitative Tl SPECT than of MR for monitoring purposes and our results indicated that treatment induced MR changes were interrelated with TI-uptake variations. - Multi-voxel H-MRS was difficult to apply for astrocytoma treatment monitoring, due to the

  15. Unfolded map. Quantification of Tl-201 myocardial single photon emission computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Shimada, Tomoyoshi; Kurimoto, Tohru; Kamihata, Hiroshi

    1987-06-01

    A new method was devised using Tl-201 myocardial SPECT to quantify the extent of myocardial ischemia and to improve the diagnostic usefulness, and a basic study for the clinical application of this method was performed. After the perimeters of short axis tomograms were determined using cut-off value, maximal count profiles of each tomograms were unfolded and were arranged in order from apex to base of left ventricle into two-dimensional plane. The abnormal defect was defined as the region below the standard value (percent max. count, %MC) and the area of this region was calculated as ratio of hypoperfusional to total pixels of whole map area. In the study using the left ventricular phantom, the relative error of calculated defect area were 26.4 +- 23.5 % (mean +- SD). In 15 patients (myocardial infarction (MI): 5, angina pectoris (AP): 5, no coronary artery disease (Cont.): 5), the unfolded maps were obtained immediately and 4 hours (RD) after exercise stress. The maximal standard value that the perfusion defect could not be detected in RD map were as follows, MI; 47.9 +- 10.3, AP; 56.4 +- 4.5, Cont.; 66.0 +- 1.7 %MC. Therefore, two standard values are necessary for detecting the transient ischemic and the infarcted region. In 31 patients with coronary artery disease, accuracy of this method using two standard values were 84 % and 82 %, in AP and MI, respectively. And there were significant correlations between the infarcted area obtained by this method and the asynergy score of LVG and the ejection fraction. This method is useful for the diagnosis and the quantification of myocardial ischemia.

  16. Research on casting process of ZL201 aluminum alloy and motherboard properties made of the same%ZL201铝合金底板铸造工艺和性能研究

    Institute of Scientific and Technical Information of China (English)

    成建国; 张广明; 朱秀荣

    2010-01-01

    在普通红砂湿型、手工造型条件下,确定了合理的铸造工艺方案,铸造出合格的ZL201铝合金底板铸件.铸件实现均衡凝固,避免了气孔和疏松的产生.测试了铸件的力学性能并进行了金相组织观察,铸件的力学性能Rm=250 N/nun2、A=4%,满足使用要求.

  17. 地震资料在车古201块储层建模中的应用%Application of Seismic Data to Reservoir Modeling of the Chegu 201 Block

    Institute of Scientific and Technical Information of China (English)

    蔡毅; 张祥忠; 张新赏

    2005-01-01

    Great uncertainty exists in reservoir models built for blocks where well spacing is uneven or large. The uncertainty in reservoir models can be significantly reduced by using Coordinate Cokriging Sequential Gaussian Simulation technology, in combination with the restriction of seismic characteristic data. Satisfactory reservoir parameter interpolation results, which are more accurate than those derived only from borehole data, are obtained, giving rise to a reasonable combination of widespread and dense-sampled seismic (soft data) data with borehole data (hard data). A significant effect has been made in reservoir parameter modeling in the Chegu 201 block of the Futai Oilfield by using this technology.

  18. HPLC考察DA201大孔树脂对芍药苷的吸附容量%Study on Adsorption Capacity of Paeoniflorin on DA201 Macro Reticular Resin by HPLC Method

    Institute of Scientific and Technical Information of China (English)

    滕坤; 张莲珠; 张海丰

    2006-01-01

    白芍是毛茛科植物芍药(Paeonia lactiflora Pall.)的干燥根,主要活性成分为芍药苷.现代药理研究表明,芍药苷具有抗炎、镇痛、抗惊厥和免疫调节等作用,临床应用广泛,疗效确切.笔者就DA201大孔树脂对芍药苷的吸附容量进行考察,为更好地分离纯化芍药苷提供参考.

  19. Coadsorption behavior of salicylic acid and sulfosalicylic acid on D201 resin%水杨酸和磺基水杨酸在D201树脂上的共吸附行为

    Institute of Scientific and Technical Information of China (English)

    谢祖芳; 陈渊; 晏全; 童张法; 杨凯清

    2011-01-01

    采用静态法和动态法研究了水溶液中水杨酸和磺基水杨酸在D201树脂上的共吸附行为和吸附选择性.同时竞争吸附、预负荷竞争吸附和等温吸附的结果均表明:水杨酸的存在对磺基水杨酸的吸附影响较小,而磺基水杨酸的存在则大大削弱了水杨酸的吸附,2种溶质在吸附位点上的竞争为主要作用机制.在双溶质(质量浓度比为1∶1)吸附体系中,初始质量浓度对吸附选择性的影响明显,初始质量浓度≤500 mg/L时,树脂对水杨酸或磺基水杨酸的吸附选择性均很小;初始浓度为1 000-2 000 mg/L时,树脂对磺基水杨酸有很高的吸附选择性,利于二者的选择吸附分离.对初始质量浓度均为2 000 mg/L的双溶质水溶液的动态吸附与脱附表明,以1.000 g树脂装柱,吸附出水在250 mL泄漏点内几乎只含水杨酸,磺基水杨酸被吸附于树脂上.室温下以质量分数5%NaCl+2%NaOH溶液作为脱附剂,可完全洗脱树脂上吸附的磺基水杨酸和水杨酸,其分离系数为300,磺基水杨酸的回收率为96%.应用D201树脂能有效实现磺基水杨酸与水杨酸的选择性吸附分离.%The coadsorption behavior and selectivity of salicylic acid and sulfosalicylic acid from aqueous solution on D201 resin were studied by using static and dynamic methods.The experimental results of the simultaneously competitive adsorption, preloading competitive adsorption and isotherm adsorption processes indicate that salicylic acid has very little influence on D201 resin adsorption of the sulfosalicylic acid, but the latter significantly depresses the adsorption of the salicylic acid.The predominant mechanism attributes to the competition of salicylic acid and sulfosalicylic acid for adsorption sites.In the binary solution of salicylic acid and sulfosalicylic acid (mass concentration ratio of 1: 1 ), the initial mass concentration can significantly affect the adsorption selectivity of D201 resin.At an initial

  20. Mimicry epitope from Ehrlichia canis for interphotoreceptor retinoid-binding protein 201-216 prevents autoimmune uveoretinitis by acting as altered peptide ligand.

    Science.gov (United States)

    Gangaplara, Arunakumar; Massilamany, Chandirasegaran; Steffen, David; Reddy, Jay

    2013-10-15

    We report here identification of novel mimicry epitopes for interphotoreceptor retinoid-binding protein (IRBP) 201-216, a candidate ocular antigen that causes experimental autoimmune uveoretinitis (EAU) in A/J mice. One mimicry epitope from Ehrlichia canis (EHC), designated EHC 44-59, induced cross-reactive T cells for IRBP 201-216 capable of producing T helper (Th)1 and Th17 cytokines, but failed to induce EAU in A/J mice. In addition, animals first primed with suboptimal doses of IRBP 201-216 and subsequently immunized with EHC 44-59 did not develop EAU; rather, the mimicry epitope prevented the disease induced by IRBP 201-216. However, alteration in the composition of EHC 44-59 by substituting alanine with valine at position 49, similar to the composition of IRBP 201-216, enabled the mimicry epitope to acquire uveitogenicity. The data provide new insights as to how microbes containing mimicry sequences for retinal antigens can prevent ocular inflammation by acting as naturally occurring altered peptide ligands.

  1. Relation between Tc-99m-PYP and Tl-201 scintigraphic findings and left ventricular function in acute myocardial infarction with early reperfusion

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Takao; Fukuzaki, Hisashi; Igarashi, Yuuichirou; Minamiji, Katsumi; Takarada, Akira; Imai, Naoaki; Fujino, Motohiro; Kurogane, Hiroyuki; Yoshida, Yutaka.

    1988-07-01

    The purpose of this study was to examine the significance of Tc-99m PYP uptake in the evaluation of myocardial salvage and reperfusion injury during early reperfusion in acute myocardial infarction. The subjects were 54 patients with initial myocardial infarction attributable to left anterior descending branch lesion in whom early reperfusion was attained by spontaneous recanalization (SR), intracoronary thrombolysis (ICT), and percutaneous transluminal angioplasty (PTCA). The radionuclide imaging appearances of the myocardium fell into four categories : I) small Tl-201 defect and faint Tc-99m PYP uptake ; II) small Tl-201 defect and intense Tc-99m PYP uptake ; III) large Tl-201 defect and faint Tc-99m PYP uptake ; and IV) large Tl-201 defect and intense Tc-99m PYP uptake. The incidences of I and II were higher in the group of SR patients than the group of ICT and PTCA patients. Features of left ventricular ejection fraction (LVEF) from the acute through the chronic stages were as follows : Category I - favorable LVEF through the stages ; Category II - improvement at chronic stage ; Category III - no consistent tendency for LVEF ; and Category IV - aggravation at chronic stage. In cases of early recanalization of acute myocardial infarction, Tc-99m PYP images combined with Tl-201 images may provide useful information on changes of cardiac function and salvage of the ischemic myocardium. (Namekawa, K.).

  2. Phantom evaluation of scatter and attenuation correction in thallium-201/technetium-99m acquisition in myocardial perfusion single-photon emission computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Ohyama, Yoichi; Tomiguchi, Seiji; Kira, Tomohiro; Kojima, Akihiro; Matsumoto, Masanori; Nishi, Jyunko; Katsuda, Noboru; Takahashi, Mutsumasa [Kumamoto Univ. (Japan). School of Medicine; Motomura, Nobutoku

    2001-04-01

    This phantom study was carried out to evaluate the usefulness of scatter correction combined with transmission-based attenuation correction in separate and simultaneous {sup 201}Tl/{sup 99m}Tc myocardial SPECT. An anthropomorphic torso phantom was used in this study. We used the triple-energy-window (TEW) method for scatter correction and transmission computed tomography (TCT) images for attenuation correction. Images without corrections (UC) and images with corrections (SAC) for scatter and attenuation were reconstructed for the evaluation. The differences in defect size between {sup 99m}Tc and {sup 201}Tl UC images led to interpretation errors in separate (separate protocol) and simultaneous dual-isotope studies (simultaneous protocol). These errors were more prominent in the infero-posterior wall in the simultaneous protocol. Improvement for overestimation in object size and underestimation in defect contrast was visually obtained, and increased contrast was also shown by the myocardium-to-defect count (MD) ratios on SAC images in the separate and simultaneous protocols. However, {sup 201}Tl SAC images in the simultaneous protocol still had less defect contrast than the corresponding {sup 201}Tl SAC images in the separate protocol. From the results of our phantom experiment, separate rest {sup 201}Tl/ stress {sup 99m}Tc-sestamibi acquisitions may be recommended in clinical practice. Further clinical and phantom studies will be needed to validate the method using scatter correction combined with transmission-based attenuation correction. (author)

  3. Subcutaneous injection of thallium-201 chloride and gallium-67 citrate at acupuncture point K-3; An animal experiment and human-being study

    Energy Technology Data Exchange (ETDEWEB)

    Johg, Shiang-Bin; Wu, Chung-Chieng; Chen, Ming-Feng; Wu, Sheng-Nan (Kaohsiung Medical Coll., Taiwan (China))

    1992-09-01

    Subcutaneous (SC) injection of [sup 99m]Tc pertechnetate ([sup 99m]Tc) at acupuncture points K-3 is a new method of lower-limb radionuclide venography. To investigate the mechanism of absorption of [sup 99m]Tc from SC injected sites into vascular system, various radioisotopes such as [sup 201]Tl chloride ([sup 201]Tl) and [sup 67]Ga citrate ([sup 67]Ga) were SC injected at K-3 points in animal and human-beings experiments. It was found that [sup 99m]Tc and [sup 201]Tl were absorbed rapidly from K-3 points through venous system and into whole body soft tissue. However, [sup 67]Ga with a larger effective ionic radius than [sup 201]Tl was not absorbed throughout the observation of 5 minutes. Furthermore, intravenous administration of digitalis, a Na[sup +]-K[sup +] pump blocker, did not inhibit the absorption of [sup 99m]Tc and [sup 201]Tl after SC injection at K-3 points. These results suggest that absorption of radionuclides on SC injection at K-3 points is mainly through the passive pathway of diffusion rather than the active transport, and the effective ionic radius may be a major factor influencing the absorption rate of the radionuclides. (author).

  4. Relation between myocardial damage and disease activity in patients with systemic lupus erythematosus by exercise {sup 201}Tl scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Kuzumoto, Masayuki [Nara Medical Univ. (Japan)

    1997-08-01

    Myocardial damage in patients with systemic lupus erythematosus (SLE) was evaluated using exercise thallium-201 myocardial scintigraphy, and the relationship between myocardial damage and disease activity of SLE was examined. Twenty-seven patients (26 women and 1 man, mean age 43 years), in whom extramural coronary artery lesions were excluded by coronary angiogram or presumed to be excluded by exercise electrocardiogram, were enrolled in this study. The mean duration of disease and the mean duration of corticosteroid therapy in these patients were 94 and 77 months, respectively. Exercise thallium-201 scintigraphy was performed twice (mean interval, 30 months) to evaluate the progression of myocardial damage. Myocardial ischemia as an index of myocardial damage was evaluated by visual analysis and ischemic score (IS). The changes in myocardial ischemia were categorized into 3 groups: improved, unchanged or worsened. The disease activity of SLE was determined by the SLE Disease Activity Index (SLEDAI), and the changes in this index were classified into the same three categories, as evaluated every six months between the two scintigraphic examinations. Disease activity was significantly correlated with myocardial ischemia (p<0.05), and with myocardial ischemia as diagnosed by {Delta}IS (difference in ischemic score between the first and second thallium-201 scintigrams: p<0.005). But neither the duration of disease nor the duration of corticosteroid therapy was correlated with IS at the first scintigraphy. These results indicate that control of SLE disease activity may be critical in the treatment of myocardial damage resulting from vascular lesions, especially intramyocardial small-artery disease, in patients with SLE. (author)

  5. Characterization of modular bacteriophage endolysins from Myoviridae phages OBP, 201φ2-1 and PVP-SE1.

    Directory of Open Access Journals (Sweden)

    Maarten Walmagh

    Full Text Available Peptidoglycan lytic enzymes (endolysins induce bacterial host cell lysis in the late phase of the lytic bacteriophage replication cycle. Endolysins OBPgp279 (from Pseudomonas fluorescens phage OBP, PVP-SE1gp146 (Salmonella enterica serovar Enteritidis phage PVP-SE1 and 201φ2-1gp229 (Pseudomonas chlororaphis phage 201φ2-1 all possess a modular structure with an N-terminal cell wall binding domain and a C-terminal catalytic domain, a unique property for endolysins with a Gram-negative background. All three modular endolysins showed strong muralytic activity on the peptidoglycan of a broad range of Gram-negative bacteria, partly due to the presence of the cell wall binding domain. In the case of PVP-SE1gp146, this domain shows a binding affinity for Salmonella peptidoglycan that falls within the range of typical cell adhesion molecules (K(aff = 1.26 × 10(6 M(-1. Remarkably, PVP-SE1gp146 turns out to be thermoresistant up to temperatures of 90 °C, making it a potential candidate as antibacterial component in hurdle technology for food preservation. OBPgp279, on the other hand, is suggested to intrinsically destabilize the outer membrane of Pseudomonas species, thereby gaining access to their peptidoglycan and exerts an antibacterial activity of 1 logarithmic unit reduction. Addition of 0.5 mM EDTA significantly increases the antibacterial activity of the three modular endolysins up to 2-3 logarithmic units reduction. This research work offers perspectives towards elucidation of the structural differences explaining the unique biochemical and antibacterial properties of OBPgp279, PVP-SE1gp146 and 201φ2-1gp229. Furthermore, these endolysins extensively enlarge the pool of potential antibacterial compounds used against multi-drug resistant Gram-negative bacterial infections.

  6. Sulfamethoxazole induces a switch mechanism in T cell receptors containing TCRVβ20-1, altering pHLA recognition.

    Directory of Open Access Journals (Sweden)

    Stephan Watkins

    Full Text Available T cell receptors (TCR containing Vβ20-1 have been implicated in a wide range of T cell mediated disease and allergic reactions, making it a target for understanding these. Mechanics of T cell receptors are largely unexplained by static structures available from x-ray crystallographic studies. A small number of molecular dynamic simulations have been conducted on TCR, however are currently lacking either portions of the receptor or explanations for differences between binding and non-binding TCR recognition of respective peptide-HLA. We performed molecular dynamic simulations of a TCR containing variable domain Vβ20-1, sequenced from drug responsive T cells. These were initially from a patient showing maculopapular eruptions in response to the sulfanilamide-antibiotic sulfamethoxazole (SMX. The CDR2β domain of this TCR was found to dock SMX with high affinity. Using this compound as a perturbation, overall mechanisms involved in responses mediated by this receptor were explored, showing a chemical action on the TCR free from HLA or peptide interaction. Our simulations show two completely separate modes of binding cognate peptide-HLA complexes, with an increased affinity induced by SMX bound to the Vβ20-1. Overall binding of the TCR is mediated through a primary recognition by either the variable β or α domain, and a switch in recognition within these across TCR loops contacting the peptide and HLA occurs when SMX is present in the CDR2β loop. Large binding affinity differences are induced by summed small amino acid changes primarily by SMX modifying only three critical CDR2β loop amino acid positions. These residues, TYRβ57, ASPβ64, and LYSβ65 initially hold hydrogen bonds from the CDR2β to adjacent CDR loops. Effects from SMX binding are amplified and traverse longer distances through internal TCR hydrogen bonding networks, controlling the overall TCR conformation. Thus, the CDR2β of Vβ20-1 acts as a ligand controlled switch

  7. Phantom study to evaluate quantitative changes in myocardial radioisotope concentration for single photon emission computed tomography; Comparison between Tl-201 and Tc-99m

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, Takashi; Kitabata, Yoshiki; Tanaka, Takeshi; Hasegawa, Mitsuo; Kato, Kazuzo (Cardiovascular Inst., Tokyo (Japan)); Okabe, Akifumi

    1990-01-01

    Quantitative changes in Tl-201 and Tc-99m in myocardial single photon emission computed tomography (SPECT) were evaluated using phantom studies. The absorption rate of gamma ray by the tissues surrounding the myocardium was less for Tc-99m (maximum, 61.2%) than Tl-201 (maximum, 70.8%). In studies on quantification of defects with various concentrations of the radioisotopes, Tc-99m was found superior to Tl-201. In comparing a focal defect in the anterior wall near the surface of the thorax (Defect A) with that in the posterior wall deep in the thorax (Defect B), Defect A had a better quantification than Defect B. Absorber, scattering, and background, however, precluded quantification, especially in Defect B. Although scatter subtraction may in part improve quantification, quantification seemed to be dependent on algorithm in image reconstruction, as well as spatial resolution of the equipment. (N.K.).

  8. Evaluation of clinical usefulness of myocardial perfusion imaging with tetrofosmin in patients with ischemic heart disease. Comparison with [sup 201]Tl SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, Tsuyoshi; Sasaki, Masayuki; Ichiya, Yuichi (Kyushu Univ., Fukuoka (Japan). Faculty of Medicine) (and others)

    1994-09-01

    We evaluated the clinical usefulness of [sup 99m]Tc-1, 2-bis[bis(2-ethoxyethyl)phosphino]ethane (tetrofosmin) and compared it with [sup 201]Tl. The subjects consisted of 12 patients including 8 patients with old myocardial infarction (OMI), 2 with effort angina, one with stable angina and one with myocarditis. The tetrofosmin SPECT images were obtained during exercise and at rest. The quality of tetrofosmin SPECT images was equal or slightly superior to that of [sup 201]Tl. And the sensitivity, specificity and accuracy of tetrofosmin for the detection of coronary stenosis and/or obstruction were equal to that of [sup 201]Tl. We conclude that tetrofosmin is useful in the diagnosis of ischemic heart disease. (author).

  9. KEY COMPARISON: Activity measurements of the radionuclide 201Tl for the LNE-LNHB, France, PTB, Germany and the NPL, UK in the ongoing comparison BIPM.RI(II)-K1.Tl-201

    Science.gov (United States)

    Ratel, G.; Michotte, C.; Moune, M.; Bobin, C.; Kossert, K.; Johansson, L.

    2008-01-01

    In 2005, the Laboratoire national de métrologie et essais-Laboratoire national Henri Becquerel (LNE-LNHB) and the Physikalisch-Technische Bundesanstalt (PTB) each submitted a sample of known activity of 201Tl to the International Reference System (SIR). In 2006, the National Physical Laboratory (NPL) submitted their first sample. The range of values of the activity submitted was between 2 MBq and 63 MBq. These key comparison results have been included in the re-evaluated key comparison reference value and replaced the previous results for France and Germany in the matrix of degrees of equivalence in the key comparison database that now contains seven results, identifier BIPM.RI(II)-K1.Tl-201. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCRI Section II, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  10. Use of thallium-201 myocardial scintigraphy for the prediction of the response to {beta}-blocker therapy in patients with dilated cardiomyopathy

    Energy Technology Data Exchange (ETDEWEB)

    Hara, Yuji; Hamada, Mareomi; Ohtsuka, Tomoaki; Ogimoto, Akiyoshi; Saeki, Hideyuki; Suzuki, Jun; Matsunaka, Tsuyoshi; Nakata, Shigeru; Shigematsu, Yuji [Ehime Univ., Shigenobu (Japan). School of Medicine

    2002-12-01

    This study was performed to evaluate whether thallium-201 myocardial scintigraphy (Tl-201) and iodine-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy could predit the usefulness of {beta}-blocker therapy in patients with dilated cardiomyopathy (DCM). Tl-201 and MIBG were performed in 47 patients before {beta}-blocker therapy. Patients were classified into group A, if their cardiac function improved, and group B, whose function remained unchanged Two types of extent score (ES) by Tl-201 were proposed to quantitate myocardial damage, mean-2SD (ES-2) and mean -3SD (ES-3). The ES difference between ES-2 and ES-3 was calculated, and according to ES and ES difference, DCM cases were classified into 3 groups: mild-defect type (mild-type), moderate-defect type (moderate-type) and severe-defect type (severe-type). The heart-to-mediastinum (H/M) MIBG uptake ratio was evaluated, and the percent washout ratio of myocardial MIBG was obtained from these data. Group A comprised 18 mild-type, 14 moderate-type and 1 severe-type cases, and group B comprised 5 mild-type, 4 moderate-type and 5 severe-type cases. A significant relation was observed between the defect type on Tl-201 and the response to {beta}-blocker therapy (p=0.0090). Both H/M MIBG uptake ratios and washout ratio were not significantly different in the 2 groups. Tl-201 may be useful for predicting the response to {beta}-blocker therapy in patients with DCM. (author)

  11. Comparison of arbutamine stress and treadmill exercise thallium-201 SPECT: Hemodynamics, safety profile and diagnostic accuracy

    Energy Technology Data Exchange (ETDEWEB)

    Kiat, H.; Berman, D.S. [Cedars-Sinai Medical Centre, Los Angeles, California, LA (United States)

    1998-02-01

    Full text: Arbutamine (ARB), a new pharmacologic stress agent with enhanced chronotropic property compared to dobutamine, was compared with treadmill (TM) exercise testing (Ex) in a multicenter study using thallium-201 (Tl) SPECT. Of the total of 184 patients who underwent ARB, 69 also had TM stress and quantitative coronary angiography. Fifty-eight patients with a low pretest likelihood of CAD also underwent ARB study for evaluation of test specificity (normalcy rate). Tl scans were scored by a central laboratory using a 20 segment (seg)/scan visual analysis (5 point system: 0=normal, 4-absent uptake). Maximum heart rate (HR) by ARB and Ex was 122 vs 141 bpm (p<0.05). Mean %HR change from baseline was similar (79% vs 82%, respectively, p=ns). Maximum systolic BP for ARB and Ex was 173 vs 175 mmHg, and mean % change from baseline was 24% vs 28% (p=ns). Sensitivity for detecting CAD (270% stenosis) by ARB Tl was 94% and 97% by Ex Tl (p=ns). Stress Tl SPECT segmental agreement for presence of defect between ARB and Ex was 92% (kappa=0.8, p<0.001). Exact segmental stress Tl score (0-4 grading) agreement was 83 % (kappa=0.7, p<0.001). Among 346 segs with stress defects by both ARB and Ex defect reversibility agreement was 86% (kappa=0.7, p<0.001). The normalcy rate for ARB TI-SPECT among patients with a low likelihood of CAD was 90%. Adverse events were mostly mild (tremor: 23%, flushing: 10%, headache: 10%, paraesthesia: 8%, dizziness: 8%, hot flushes: 4%). Arrhythimia of clinical concern occurred in 8% (10/122) of ARB patients who had cardiac catheterisation and in 1.4% (1/69) of patients who had stress Tl. Of all 184 patients with ARB stress, ARB was discontinued due to arrhythmia in 7(5%) and 1 patient had IV Metoprolol for frequent ventricular couplets. Sustained arrhythmias were not observed

  12. Utilization of AGN-201K for Education and Research in Korea

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Myung-Hyun [Department of Nuclear Engineering, Kyung Hee University, KHU Reactor Research and Education Center, Kiheung, Yongin, Gyeonggi-do, 446-701 (Korea, Republic of)

    2011-07-01

    A zero power reactor, AGN-201K has been operated in Kyung Hee University since 1982 and it was refurbished extensively three years ago. In 2008, Reactor Research and Education Center (RREC) was established for student training and research. The primary mission of RREC is an educational service for nuclear engineering students. Since January 2009, short courses were provided 15 times to 160 students from 7 universities. This course has been an one-week dormitory housing program in the name of Reactor Experiment and was designed as an advanced course customized to undergraduate senior-level. It has introductory session, safety guide session, concluding presentation session with six experiment sessions; reactor operation and control, measurement of period for reactivity, criticality approach, rod worth measurement, measurement of temperature feedback coefficient and thermal flux measurement with neutron activation analysis (NAA). As a R and D effort for future experimental courses, RREC is now seeking for the possibility of reactor utilization for prompt gamma activation analysis, NAA for material mass spectroscopy, and neutron radiography (NR). A feasibility study on NR was done with MCNP simulation on collimator design and showed that calculated thermal flux level was high enough at the object position even though image size is very small, less than 4 cm diameter. Research activity has been done for sub-criticality measurement with modified neutron source multiplication method (MNSM). For sub-criticality evaluation with this method, three kinds of the neutron flux distributions such as forward, adjoint, fixed source neutron fluxes, which are solution in both eigenvalue and fixed source problems are needed. These flux distributions were calculated by using PARTISN code systems. Physics conditions are highly dependent on the source locations and rod positions as well as detector positions. Recent results showed that this method improved accuracy in rod worth

  13. Transient transmural reduction of myocardial blood flow, demonstrated by thallium-201 scintigraphy, as a cause of variant angina

    Energy Technology Data Exchange (ETDEWEB)

    Maseri, A.; Parodi, O.; Severi, S.; Pesola, A.

    1976-08-01

    In previous studies we demonstrated that variant angina could not be attributed to increased myocardial demands. In order to investigate whether a reduction of regional myocardial blood supply could be responsible for these ischemic episodes, we studied regional myocardial perfusion in six patients admitted to our coronary care unit. Myocardial scintigrams, obtained 5-7 min following i.v. injection of 1 mCi of thallium-201, performed during an episode of ST-segment elevation, showed transmural deficits of tracer uptake in the heart wall corresponding to the leads showing ST-segment elevation. These regional deficits had disappeared by 2 hours because of late uptake in previously ischemic myocardium. One week later, following injections performed in the absence of acute ischemia, no deficit was apparent. Tracer uptake in ischemic areas was 60 percent to 85 percent of that observed a week later. After adjusting for thallium-201 kinetics and counting geometry problems, these scintigrams actually represent large underestimations of actual flow reduction. Thus variant angina appears to be caused by massive transmural reduction of myocardial blood supply.

  14. Investigation of wavelength-dependent tissue ablation: visible (λ=532 nm) vs IR (λ=2.01 μm)

    Science.gov (United States)

    Kang, Hyun Wook; Peng, Yihlih Steven

    2010-02-01

    Laser prostatectomy with various lasers has been shown to be effective in the treatment of benign prostate hyperplasia. However, the impact of laser parameters on tissue ablation is still in question. The aim of this study is to experimentally characterize laser-tissue interactions in terms of wavelength by comparing visible (λ= 532 nm) and infrared (λ= 2.01 μm) spectra. Porcine kidney tissue was used as it has thermal properties and glandular structure similar to human prostatic tissue. Q-switched 532 nm (GreenLightTM HPS) and continuous-wave (CW) 2.01 μm (custom-made Tm:YAG) lasers were employed to remove soft tissue under various settings (power, working distance, and treatment speed). For both laser systems, ablation rate increased with power and was maximized at 4 mm/s. The 532 nm laser generated approximately 30% (pHistology also confirmed coagulation depth in response to each wavelength. Due to light absorption in aqueous environment, the IR laser exhibited a dramatic decrease in power transmission and ablation volume with increasing working distance whereas the 532 nm laser maintained relatively constant features. In conclusion, the characteristics of tissue ablation were contingent upon the applied wavelengths due to optical properties and laser parameters.

  15. Localization of parathyroid enlargement: experience with technetium-99m methoxyisobutylisonitrile and thallium-201 scintigraphy, ultrasonography and computed tomography

    Energy Technology Data Exchange (ETDEWEB)

    Geatti, O. (Ist. di Medicina Nucleare, Ospedale Civile, Udine (Italy)); Shapiro, B. (Div. of Nuclear Medicine, Michigan Univ., Ann Arbor, MI (United States)); Orsolon, P.G. (Ist. di Medicina Nucleare, Ospedale Civile, Udine (Italy)); Proto, G. (Endocrinologia, Ospedale Civile, Udine (Italy)); Guerra, U.P. (Ist. di Medicina Nucleare, Ospedale Civile, Udine (Italy)); Antonucci, F. (Nefrologia, Ospedale Civile, Udine (Italy)); Gasparini, D. (Ist. di Radiologia 2, Ospedale Civile, Udine (Italy))

    1994-01-01

    Technetium-99m methoxyisobutylisonitrile (MIBI), like thallium-201, has recently been introduced as a myocardial perfusion agent and is now also showing very promising results in parathyroid scintigrapy. The results of [sup 201]Tl/[sup 99m]Tc-pertechnetate and [sup 99m]Tc/MIBI/[sup 99m]Tc-pertechnetate subtraction scintigraphy, ultrasonography and computed tomography are presented in a series of 43 patients operated on for hyperparathyroidism. All four imaging modalities were confirmed to be reliable, scintigraphy being the most accurate. Sensitivities ranged from 81% to 95%, that of [sup 99m]Tc-MIBI being the highest. Moreover this tracer, which has more favourable physical and also biochemical properties, yielded images of superior quality. This allowed localization of the lesion by visual inspection only is as many as 86% of the patients with positive [sup 99m]Tc-MIBI/n9[sup 9m]Tc-pertechnetate subtraction scintigraphy. We believe that the higher sensitivity, superior image quality and lower cost of [sup 99m]Tc-MIBI imaging will make [sup 99m]Tc-MIBI the new radiopharmaceutical of choice for parathyroid scintigraphy (when one takes into account) the stability of labelling with large activities it is possible to perform three or four cardiac studies together with one parathyroid scintigraphic examination using one lyophililzed vial. (orig.)

  16. CD8 Knockout Mice Are Protected from Challenge by Vaccination with WR201, a Live Attenuated Mutant of Brucella melitensis

    Directory of Open Access Journals (Sweden)

    Samuel L. Yingst

    2013-01-01

    Full Text Available CD8+ T cells have been reported to play an important role in defense against B. abortus infection in mouse models. In the present report, we use CD8 knockout mice to further elucidate the role of these cells in protection from B. melitensis infection. Mice were immunized orally by administration of B. melitensis WR201, a purine auxotrophic attenuated vaccine strain, then challenged intranasally with B. melitensis 16M. In some experiments, persistence of WR201 in the spleens of CD8 knockout mice was slightly longer than that in the spleens of normal mice. However, development of anti-LPS serum antibody, antigen-induced production of γ-interferon (IFN-γ by immune splenic lymphocytes, protection against intranasal challenge, and recovery of nonimmunized animals from intranasal challenge were similar between normal and knockout animals. Further, primary Brucella infection was not exacerbated in perforin knockout and Fas-deficient mice and these animals’ anti-Brucella immune responses were indistinguishable from those of normal mice. These results indicate that CD8+ T cells do not play an essential role as either cytotoxic cells or IFN-γ producers, yet they do participate in a specific immune response to immunization and challenge in this murine model of B. melitensis infection.

  17. M dwarfs in the b201 tile of the VVV survey: Colour-based Selection, Spectral Types and Light Curves

    CERN Document Server

    Rojas-Ayala, Bárbara; Minniti, Dante; Saito, Roberto K; Surot, Francisco

    2014-01-01

    The intrinsically faint M dwarfs are the most numerous stars in the Galaxy, have main-sequence lifetimes longer than the Hubble time, and host some of the most interesting planetary systems known to date. Their identification and classification throughout the Galaxy is crucial to unravel the processes involved in the formation of planets, stars and the Milky Way. The ESO Public Survey VVV is a deep near-IR survey mapping the Galactic bulge and southern plane. The VVV b201 tile, located in the border of the bulge, was specifically selected for the characterisation of M dwarfs. We used VISTA photometry to identify M dwarfs in the VVV b201 tile, to estimate their subtypes, and to search for transit-like light curves from the first 26 epochs of the survey. UKIDSS photometry from SDSS spectroscopically identified M dwarfs was used to calculate their expected colours in the $YJHK_s$ VISTA system. A colour-based spectral subtype calibration was computed. Possible giants were identified by a $(J-K_s, H_{J})$ reduced ...

  18. Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201 on respiratory and systemic infections in mice caused by cowpox and vaccinia viruses.

    Directory of Open Access Journals (Sweden)

    Donald F Smee

    Full Text Available An adenovirus 5 vector encoding for mouse interferon alpha, subtype 5 (mDEF201 was evaluated for efficacy against lethal cowpox (Brighton strain and vaccinia (WR strain virus respiratory and systemic infections in mice. Two routes of mDEF201 administration were used, nasal sinus (5-µl and pulmonary (50-µl, to compare differences in efficacy, since the preferred treatment of humans would be in a relatively small volume delivered intranasally. Lower respiratory infections (LRI, upper respiratory infections (URI, and systemic infections were induced by 50-µl intranasal, 10-µl intranasal, and 100-µl intraperitoneal virus challenges, respectively. mDEF201 treatments were given prophylactically either 24 h (short term or 56d (long-term prior to virus challenge. Single nasal sinus treatments of 10(6 and 10(7 PFU/mouse of mDEF201 protected all mice from vaccinia-induced LRI mortality (comparable to published studies with pulmonary delivered mDEF201. Systemic vaccinia infections responded significantly better to nasal sinus delivered mDEF201 than to pulmonary treatments. Cowpox LRI infections responded to 10(7 mDEF201 treatments, but a 10(6 dose was only weakly protective. Cowpox URI infections were equally treatable by nasal sinus and pulmonary delivered mDEF201 at 10(7 PFU/mouse. Dose-responsive prophylaxis with mDEF201, given one time only 56 d prior to initiating a vaccinia virus LRI infection, was 100% protective from 10(5 to 10(7 PFU/mouse. Improvements in lung hemorrhage score and lung weight were evident, as were decreases in liver, lung, and spleen virus titers. Thus, mDEF201 was able to treat different vaccinia and cowpox virus infections using both nasal sinus and pulmonary treatment regimens, supporting its development for humans.

  19. Examples of Systems of Functions Being Riesz Bases in L_{2}(0,1). Application to a Nonlinear Boundary Value Problem

    CERN Document Server

    Zhidkov, P E

    2001-01-01

    We establish examples of systems of functions being Riesz bases in L_{2}(0,1). We then apply this result to improve a theorem presented in [9] showing that an arbitrary "standard" system of solutions of a nonlinear boundary value problem, normalized to 1 in the same space, is a Riesz basis in this space. The proofs in this work are quite elementary.

  20. Myocardial scintigraphy with iodine-123 phenylpentadecanoic acid and thallium-201 in patients with coronary artery disease: A comparative dual-isotope study

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, R.; Rauch, B.; Kapp, M.; Neumann, F.J.; Seitz, F.; Kuebler, W. (Heidelberg Univ. (Germany). Dept. of Cardiology); Bubeck, B. (Heidelberg Univ. (Germany). Dept. of Nuclear Medicine); Mall, G. (Heidelberg Univ. (Germany). Dept. of Pathology); Tillmanns, H. (Giessen Univ. (Germany). Dept. of Cardiology); Stokstad, P.

    1992-11-01

    To characterise the clinical usefulness of serial myocardial scintigraphy with iodine-123 phenylpentadecanoic acid (IPPA) in comparison with thallium-201, dual-isotope investigations were performed in 41 patients with angiographically documented coronary artery disease. Both tracers were adminstered simultaneously during symptom-limited ergometry. Planar scintigrams were acquired immediately after stress, and delayed imaging was performed after 1 h for IPPA and 4 h for {sup 201}Tl. Scintigrams were evaluated both qualitatively and quantitatively using a newly developed algorithm for automated image superposition. Initial myocardial uptake of both tracers was closely correlated (r=0.75, p<0.001). Both tracers also revealed a similar sensitivity for the identification of individual coronary artery stenoses {>=}75% (IPPA: 70%, {sup 201}Tl: 66.3%, P=NS) with identical specificity (69.8%). The number of persistent defects, however, was significantly higher with IPPA (P=0.021), suggesting that visual analysis of serial IPPA scintigrams may overestimate the presence of myocardial scar tissue. On the other hand, previous Q wave myocardial infarction was associated with a decreased regional IPPA clearance (29%{+-}11% vs 44%{+-}11% in normal myocardium, P<0.05). The data indicate that serial myocardial scintigraphy with IPPA is essentially as sensitive as scintigraphy with {sup 201}Tl for the detection of stress-induced perfusion abnormalities. Quantitative analysis of myocardial IPPA kinetics, however, is required for the evaluation of tissue viability. (orig.).

  1. 21 CFR 201.325 - Over-the-counter drugs for vaginal contraceptive and spermicide use containing nonoxynol 9 as the...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Over-the-counter drugs for vaginal contraceptive... Products § 201.325 Over-the-counter drugs for vaginal contraceptive and spermicide use containing nonoxynol... use of vaginal contraceptive drug products containing nonoxynol 9 does not protect against...

  2. Evaluation of the effect of reconstructed image pixel size on defect detectability in Tl-201 fan-beam SPECT by an observer performance study

    Energy Technology Data Exchange (ETDEWEB)

    Gregoriou, G.K.; Tsui, B.M.W. [Univ. of North Carolina, Chapel Hill, NC (United States); Gullberg, G.T. [Univ. of Utah, Salt Lake City, UT (United States)

    1995-08-01

    The effect of reconstructed image pixel size in the fan-beam filtered backprojection method in myocardial defect detection was investigated using an observer performance study and receiver operating characteristics (ROC) analysis. A mathematical phantom of the human torso was used to model the anatomy and Thallium-201 (TI-201) uptake in humans. Realistic projections from the phantom were simulated using a low-energy high resolution fan-beam collimator that incorporated the effects of photon attenuation, spatially varying detector response, scatter, and Poison noise. For a fan beam collimator with a focal length of 55 cm and with a radius of rotation of 25 cm, the magnification at the center of rotation was two and the maximum magnification in the reconstructed region of interest was three. Myocardial defects were simulated as Gaussian-shaped decreases in Tl-201 uptake distribution. By changing the reconstructed image pixel size, five different classes of reconstructed images resulted, with projection bin width to reconstructed image pixel size (PBIP) ratios of 1, 2, 3, 4, and 5. The results from the observer study indicate that the reconstructed image pixel size has a significant effect on myocardial defect detection in reconstructed Tl-201 SPECT images. Moreover, the study indicated that in order to ensure maximum defect delectability the PBIP ratio should be at least as large as the maximum possible magnification within the reconstructed image array.

  3. 40 CFR 201.24 - Procedures for measurement at a 30 meter (100 feet) distance of the noise from locomotive and...

    Science.gov (United States)

    2010-07-01

    ... meter (100 feet) distance of the noise from locomotive and rail car operations and locomotive load cell... Measurement Criteria § 201.24 Procedures for measurement at a 30 meter (100 feet) distance of the noise from... locomotives have passed a distance 152.4 meters (500 feet) or 10 rail cars beyond the point at...

  4. Indium-111 antimyosin antibody imaging and thallium-201 imaging. A comparative myocardial scintigraphic study using single-photon emission computed tomography in patients with myocarditis and dilated cardiomyopathy

    Energy Technology Data Exchange (ETDEWEB)

    Yamada, Takehiko; Matsumori, Akira; Nohara, Ryuji; Konishi, Junji; Sasayama, Shigetake [Kyoto Univ. (Japan). Faculty of Medicine; Tamaki, Nagara

    1997-10-01

    Indium-111 antimyosin antibody imaging (a tracer of myocardial necrosis) and thallium-201 imaging (a tracer of myocardial perfusion) were compared in patients with myocarditis and dilated cardiomyopathy. The distribution of each tracer and antimyosin/thallium-201 overlapping were evaluated with single-photon emission computed tomography (SPECT). Scintigraphic data were classified into 5 patterns according to the distribution of both images and were compared with histologic findings of endomyocardial biopsy: AM-D, intense and diffuse antimyosin uptake and no perfusion abnormality (active myocarditis); AM-L, localized antimyosin uptake and no perfusion abnormality (active myocarditis); HM, no antimyosin uptake with or without perfusion abnormality (healed myocarditis); DCM-NH, diffuse antimyosin uptake and inhomogeneous thallium-201 uptake (dilated cardiomyopathy); DCM-PD, diffuse or localized antimyosin uptake and myocardial perfusion defect(s) (dilated cardiomyopathy). Patients with dilated-phase hypertrophic cardiomyopathy were frequently found in the DCM-PD group. Taken together, comparative antimyosin/thallium-201 SPECT images are useful for evaluating the activity of myocarditis and ongoing myocardial damage even in areas with no perfusion in patients with dilated cardiomyopathy. (author)

  5. Hydrogen storage properties of nanosized MgH2-0.1TiH2 prepared by ultrahigh-energy-high-pressure milling.

    Science.gov (United States)

    Lu, Jun; Choi, Young Joon; Fang, Zhigang Zak; Sohn, Hong Yong; Rönnebro, Ewa

    2009-11-04

    Magnesium hydride (MgH(2)) is an attractive candidate for solid-state hydrogen storage applications. To improve the kinetics and thermodynamic properties of MgH(2) during dehydrogenation-rehydrogenation cycles, a nanostructured MgH(2)-0.1TiH(2) material system prepared by ultrahigh-energy-high-pressure mechanical milling was investigated. High-resolution transmission electron microscope (TEM) and scanning TEM analysis showed that the grain size of the milled MgH(2)-0.1TiH(2) powder is approximately 5-10 nm with uniform distributions of TiH(2) among MgH(2) particles. Pressure-composition-temperature (PCT) analysis demonstrated that both the nanosize and the addition of TiH(2) contributed to the significant improvement of the kinetics of dehydrogenation and hydrogenation compared to commercial MgH(2). More importantly, PCT cycle analysis demonstrated that the MgH(2)-0.1TiH(2) material system showed excellent cycle stability. The results also showed that the DeltaH value for the dehydrogenation of nanostructured MgH(2)-0.1TiH(2) is significantly lower than that of commercial MgH(2). However, the DeltaS value of the reaction was also lower, which results in minimum net effects of the nanosize and the addition of TiH(2) on the equilibrium pressure of dehydrogenation reaction of MgH(2).

  6. Dobutamine stress thallium-201 single-photon emission tomography versus echocardiography for evaluation of the extent and location of coronary artery disease late after myocardial infarction

    Energy Technology Data Exchange (ETDEWEB)

    Elhendy, A.; Bax, J.J.; Domburg, R.T. van; Cornel, J.H.; Roelandt, J.R.T.C. [Thoraxcenter, Univ. Hospital Rotterdam-Dijkzigt, Rotterdam (Netherlands); Valkema, R.; Reijs, A.E.M.; Krenning, E.P. [Dept. of Nuclear Medicine, University Hospital Rotterdam-Dijkzigt, Rotterdam (Netherlands)

    1999-05-01

    Dobutamine stress echocardiography and thallium-201 myocardial perfusion scintigraphy are clinically useful methods for the evaluation of coronary artery disease (CAD). However, the relative merits of these imaging modalities in the evaluation of the extent of CAD after myocardial infarction have not been well studied. The aim of this study was to compare the accuracy of dobutamine stress echocardiography and simultaneous {sup 201}Tl single-photon emission tomography (SPET) imaging for the diagnosis and localization of CAD late after acute myocardial infarction. Dobutamine (up to 40 {mu}g kg{sup -1} min{sup -1})-atropine (up to 1 mg) stress echocardiography in conjunction with stress-reinjection {sup 201}Tl SPET was performed for the evaluation of myocardial ischaemia in 90 patients with previous myocardial infarction who underwent coronary angiography. Significant CAD was predicted on bases of myocardial ischemia (new or worsening wall motion abnormalities on echocardiography and reversible perfusion defects on {sup 201}Tl SPET). Significant CAD ({>=} 50% luminal diameter stenosis) was detected in 73 (81%) patients. The sensitivity, specificity and accuracy of echocardiography in detecting remote ischaemia for the diagnosis of remote CAD (present in 53 patients) were, respectively, 79% (CI 70%-88%), 85% (CI 77%-93%) and 81% (CI 73%-90%), while the corresponding figures for {sup 201}Tl SPET were 75% (CI 66%-85%), 78% (CI 69%-87%) and 76% (CI 67%-86%) respectively (P = NS vs echocardiography). The sensitivity, specificity and accuracy of echocardiography in detecting peri-infarction ischaemia for the diagnosis of infarct-related artery stenosis (present in 70 patients) were, rspectively, 77% (CI 68%-86%), 85% (CI 78%-92%) and 79% (CI 70%-87%) while the corresponding figures for {sup 201}Tl SPET were 73% (CI 64%-82%), 85% (CI 78%-92%) and 76% (CI 67%-84%) respectively (P = NS vs echocardiography). The agreement between the two methods for the diagnosis of peri

  7. 渗碳气体对201奥氏体不锈钢低温离子渗碳效果的影响%Effect of Carburizing Gases on Low Temperature Plasma Carburization of 201 Austenitic Stainless Steel

    Institute of Scientific and Technical Information of China (English)

    王宇; 赵程

    2012-01-01

    用不同的渗碳气体对201奥氏体不锈钢进行了低温离子渗碳(DCPC)处理.实验证明,甲烷和乙炔均可在不锈钢表面形成一层无碳化铬析出的碳的过饱和固溶体(Sc相),使其表面的硬度和耐蚀性均有较大幅度的提高.但用甲烷作为渗碳气体处理的不锈钢表面有一层黑膜,破坏了不锈钢原有的光泽;而用乙炔作为渗碳气体不仅可以获得较为光亮的表面色泽,同时其硬度和耐蚀性也有进一步的提高.%The low temperature plasma carburization (DCPC) of 201 austenitic stainless steel has been done by using different carburizing gases. The results show that CH4 and C2 H2 can form a layer of carbon supersaturated solid solution (i. e. the Sc phase) on the steel surface without chromium carbide precipitation, so the surface hardness and corrosion resistance are greatly improved. But a layer of black film will form on the metal surface when CH4 is used as carburizing gases, which will destroy the original luster of stainless steel, when C2 H2 is used as carburizing gases, not only bright surface luster can be obtained, but also the hardness and corrosion resistance can be greatly improved.

  8. 结直肠癌缺陷基因201密码子点突变与大肠癌生物学特性研究

    Institute of Scientific and Technical Information of China (English)

    吴文溪; 马利民

    2000-01-01

    目的探讨结直肠癌缺陷(deleted in colorectal carcinoma, DCC)基因201密码子(codon 201)点突变与大肠癌生物学特性的关系.方法采用等位基因特异性(allele-specific)PCR扩增技术结合限制性片段长度多肽性(restricted fragment lenght polymorphism, RFLP)检测40例正常人大肠粘膜、35例大肠癌组织及相应癌旁正常粘膜的201密码子突变情况.结果大肠癌组织及癌旁正常粘膜201密码子突变率分别为71%(25/35)和60%(21/35),两者差异无显著意义.但与正常对照组33%(13/40)相比,显著增高(χ2=5.6963,P<0.025).伴淋巴结转移组和Ducks C、D群明显高于无淋巴结转移组和Dukes A、B期,而与患者性别、年龄、癌的分级、分型等因素无关.结论 DCC基因201密码子突变是大肠癌发生中的早期基因事件,且与其转移能力的加强密切相关.

  9. Absolute quantitation of myocardial blood flow with {sup 201}Tl and dynamic SPECT in canine: optimisation and validation of kinetic modelling

    Energy Technology Data Exchange (ETDEWEB)

    Iida, Hidehiro; Kim, Kyeong-Min; Nakazawa, Mayumi; Sohlberg, Antti; Zeniya, Tsutomu; Hayashi, Takuya; Watabe, Hiroshi [National Cardiovascular Center Research Institute, Department of Investigative Radiology, Suita City, Osaka (Japan); Eberl, Stefan [National Cardiovascular Center Research Institute, Department of Investigative Radiology, Suita City, Osaka (Japan); Royal Prince Alfred Hospital, PET and Nuclear Medicine Department, Camperdown, NSW (Australia); Tamura, Yoshikazu [Akita Kumiai General Hospital, Department of Cardiology, Akita City (Japan); Ono, Yukihiko [Akita Research Institute of Brain, Akita City (Japan)

    2008-05-15

    {sup 201}Tl has been extensively used for myocardial perfusion and viability assessment. Unlike {sup 99m}Tc-labelled agents, such as {sup 99m}Tc-sestamibi and {sup 99m}Tc-tetrofosmine, the regional concentration of {sup 201}Tl varies with time. This study is intended to validate a kinetic modelling approach for in vivo quantitative estimation of regional myocardial blood flow (MBF) and volume of distribution of {sup 201}Tl using dynamic SPECT. Dynamic SPECT was carried out on 20 normal canines after the intravenous administration of {sup 201}Tl using a commercial SPECT system. Seven animals were studied at rest, nine during adenosine infusion, and four after beta-blocker administration. Quantitative images were reconstructed with a previously validated technique, employing OS-EM with attenuation-correction, and transmission-dependent convolution subtraction scatter correction. Measured regional time-activity curves in myocardial segments were fitted to two- and three-compartment models. Regional MBF was defined as the influx rate constant (K{sub 1}) with corrections for the partial volume effect, haematocrit and limited first-pass extraction fraction, and was compared with that determined from radio-labelled microspheres experiments. Regional time-activity curves responded well to pharmacological stress. Quantitative MBF values were higher with adenosine and decreased after beta-blocker compared to a resting condition. MBFs obtained with SPECT (MBF{sub SPECT}) correlated well with the MBF values obtained by the radio-labelled microspheres (MBF{sub MS}) (MBF{sub SPECT} = -0.067 + 1.042 x MBF{sub MS}, p < 0.001). The three-compartment model provided better fit than the two-compartment model, but the difference in MBF values between the two methods was small and could be accounted for with a simple linear regression. Absolute quantitation of regional MBF, for a wide physiological flow range, appears to be feasible using {sup 201}Tl and dynamic SPECT. (orig.)

  10. Coronary flow reserve evaluated by {sup 201}Tl myocardial perfusion SPECT after coronary artery bypass grafting (CABG) for angina pectoris

    Energy Technology Data Exchange (ETDEWEB)

    Ishino, Yoichi; Nakata, Hajime [Univ. of Occupational and Environmental Health, Kitakyusyu, Fukuoka (Japan)

    2000-11-01

    We compared the flow reserves of the coronary bypass vessels between arterial and venous grafts by {sup 201}Tl myocardial perfusion SPECT on the patients with angina pectoris who had no past history of myocardial infarction or intervention therapy such as PTCA. Thirty two patients had undergone a total of 70 bypass grafts and 66 of them were proved to be patent at postoperative CAG. Reversible defects were observed in 6 of 40 segments (15.0%) covered by patent venous grafts, and in 11 of 26 segments (42.3%) by patent arterial grafts. The rate of postoperative reversible defects was higher in the areas grafted by artery but this had no relation with the severity of coronary artery stenosis before CABG. This reversible defect is most likely to be caused by the character of artery graft itself and this should not be considered to highly suggest the restenosis or occlusion of the graft vessel. (author)

  11. Effect of wall thickness of left ventricle on {sup 201}Tl myocardial SPECT images. Myocardial phantom study

    Energy Technology Data Exchange (ETDEWEB)

    Koto, Masanobu; Kawase, Osami [Kobe Univ. (Japan). Hospital; Namura, Hiroyuki; Yamasaki, Katsuhito; Kono, Michio

    1996-07-01

    {sup 201}Tl myocardial SPECT is known for better sensitivity, specificity, and accuracy than planar images in detecting coronary artery disease and diagnosing myocardial viability. SPECT images arc also superior to planar images in diagnostic sensitivity and anatomical orientation. However, as limitation of the spatial resolution of the machine, we often encounter poor SPECT plower image quality in patients with decreased wall thickness. To test the accuracy of SPECT images in patients with marked thinning of the left ventricular wall, as occurs in dilated cardiomyopathy, we performed a experimental study using myocardial phantom with 7 mm wall thickness. Tomographic image of the phantom images were rather heterogeneous, though no artificial defect was located Dilated cardiomyopathy is thought to be characterized by patchy defects in the left ventricle. Careful attention should be given to elucidating myocardial perfusion in patients with a thin left ventricle wall, as there are technical limitations in addition to clinical features. (author)

  12. An Alternative to Spinning Dust for the Microwave Emission of LPH 201.663+1.643 an Ultracompact HII Region

    CERN Document Server

    McCullough, P R

    2002-01-01

    The microwave spectral energy distribution of the dusty, diffuse H II region LPH 201.663+1.643 has been interpreted by others as tentative evidence for microwave emission from spinning dust grains. We present an alternative interpretation for that particular object; specifically, that an ultracompact H II region embedded within the dust cloud would explain the available observations as well or better than spinning dust. Parameters for the size, surface brightness, and flux density of the putative ultracompact HII region, derived from the microwave observations, are within known ranges. A possible candidate for such an ultracompact H II region is IRAS 06337+1051, based upon its infrared colors. However, IRAS 06337+1051's infrared flux appears to be too small to be consistent with the microwave flux required for this alternative model to explain the observations.

  13. Clinical course of cor pulmonale investigated after an interval of one year by thallium-201 myocardial SPECT scintigraphy

    Energy Technology Data Exchange (ETDEWEB)

    Yamaoka, Shimpachi; Nishimura, Kouichi; Kuno, Kenshi; Yonekura, Yoshiharu; Koide, Harutoshi.

    1988-06-01

    Cor pulmonale was evaluated in 13 patients with chronic lung disease by thallium-201 myocardial SPECT scintigraphy together with pulmonary function tests and right heart catheterization. One year later, we performed this scintigraphy again to investigate the clinical course of the cor pulmonale. In 6 of 13 patients with respiratory failure (Pao/sub 2/ less than 60 Torr), a remarkable progression in cor pulmonale was noted after one year, despite outpatient oxygen therapy. If the patients were admitted because of acute exacerbation of respiratory failure, the cor pulmonale was found to have worsened. In contrast, patients with acute exacerbation due to respiratory infection or causes other than respiratory failure, showed little change in cor pulmonale. Although patients with a marked progression of cor pulmonale tended to have poor pulmonary function data and elevated pulmonary arterial pressure, the clinical course of cor pulmonale could not be predicted from the initial pulmonary function tests or right heart catheterization.

  14. NKG201xGIA - first results for a new model of glacial isostatic adjustment in Fennoscandia

    Science.gov (United States)

    Steffen, Holger; Barletta, Valentina; Kollo, Karin; Milne, Glenn A.; Nordman, Maaria; Olsson, Per-Anders; Simpson, Matthew J. R.; Tarasov, Lev; Ågren, Jonas

    2016-04-01

    Glacial isostatic adjustment (GIA) is a dominant process in northern Europe, which is observed with several geodetic and geophysical methods. The observed land uplift due to this process amounts to about 1 cm/year in the northern Gulf of Bothnia. GIA affects the establishment and maintenance of reliable geodetic and gravimetric reference networks in the Nordic countries. To support a high level of accuracy in the determination of position, adequate corrections have to be applied with dedicated models. Currently, there are efforts within a Nordic Geodetic Commission (NKG) activity towards a model of glacial isostatic adjustment for Fennoscandia. The new model, NKG201xGIA, to be developed in the near future will complement the forthcoming empirical NKG land uplift model, which will substitute the currently used empirical land uplift model NKG2005LU (Ågren & Svensson, 2007). Together, the models will be a reference for vertical and horizontal motion, gravity and geoid change and more. NKG201xGIA will also provide uncertainty estimates for each field. Following former investigations, the GIA model is based on a combination of an ice and an earth model. The selected reference ice model, GLAC, for Fennoscandia, the Barents/Kara seas and the British Isles is provided by Lev Tarasov and co-workers. Tests of different ice and earth models will be performed based on the expertise of each involved modeler. This includes studies on high resolution ice sheets, different rheologies, lateral variations in lithosphere and mantle viscosity and more. This will also be done in co-operation with scientists outside NKG who help in the development and testing of the model. References Ågren, J., Svensson, R. (2007): Postglacial Land Uplift Model and System Definition for the New Swedish Height System RH 2000. Reports in Geodesy and Geographical Information Systems Rapportserie, LMV-Rapport 4, Lantmäteriet, Gävle.

  15. {sup 123}I-MIBG myocardial scintigraphy in diabetic patients. Relationship with {sup 201}Tl uptake and cardiac autonomic function

    Energy Technology Data Exchange (ETDEWEB)

    Nagamachi, Shigeki; Jinnouchi, Seishi; Kurose, Takeshi; Ohnishi, Takashi; Flores, L.G. II; Nakahara, Hiroshi; Futami, Shigemi; Tamura, Shozo; Matsukura, Shigeru [Miyazaki Medical Coll., Kiyotake (Japan)

    1998-12-01

    The purpose of this paper is to investigate the influence of diabetic myocardial damage (suspected myocardial damage; SMD) diagnosed by {sup 201}Tl-SPECT and diabetic cardiac autonomic neuropathy (AN) on myocardial MIBG uptake in patients with NIDDM. Eighty-seven diabetic patients divided into four subgroups: 23 with SMD (+) AN (+); 19 with SMD (+) AN (-); 27 with SMD (-) AN (+); 18 with SMD (-) AN (-), and 10 controls were studied. Both planar and SPECT images were taken at 30 minutes (early) and 3 hours (delayed) after {sup 123}I-MIBG injection. The heart to mediastinum uptake ratio (H/M) and washout ratio of {sup 123}I-MIBG (WR) were obtained from both planar images. Similarly, the difference between the {sup 201}Tl image and the {sup 123}I-MIBG image in the total uptake score (TUS) was taken as the difference in the total uptake score ({Delta}TUS) representing cardiac sympathetic denervation without SMD. On both early and delayed planar images, the mean H/M value in the subgroups of diabetic patients was significantly lower in the SMD (+) AN (+) group than in the control group, but among those subgroups, there was statistically significant difference between the SMD (+) AN (+) and SMD (-) AN (-) groups only on the delayed images. Regarding the WR value, there was no statistically significant difference among subjects. On SPECT image analysis, the diabetic subgroup with AN or SMD had statistically significant lower values for TUS than those of the control group. Among diabetics, there was a statistically significant differences between SMD [+] AN [+] and SMD [-] AN [-] on both early and delayed images. Similarly, the SMD [+] AN [-] group also had significantly lower values than those of SMD [-] AN [-] on early images. Regarding {Delta}TUS, there was a statistically significant differences between AN [+] subgroups and controls. Similarly, the mean value for {Delta}TUS was much higher in AN [+] subgroups than in AN [-] subgroups with or without SMD in diabetes

  16. [sup 123]I-MIBG myocardial scintigraphy in diabetic patients. Relationship with [sup 201]Tl uptake and cardiac autonomic function

    Energy Technology Data Exchange (ETDEWEB)

    Nagamachi, Shigeki; Jinnouchi, Seishi; Kurose, Takeshi; Ohnishi, Takashi; Flores, L.G. II; Nakahara, Hiroshi; Futami, Shigemi; Tamura, Shozo; Matsukura, Shigeru (Miyazaki Medical Coll., Kiyotake (Japan))

    1998-12-01

    The purpose of this paper is to investigate the influence of diabetic myocardial damage (suspected myocardial damage; SMD) diagnosed by [sup 201]Tl-SPECT and diabetic cardiac autonomic neuropathy (AN) on myocardial MIBG uptake in patients with NIDDM. Eighty-seven diabetic patients divided into four subgroups: 23 with SMD (+) AN (+); 19 with SMD (+) AN (-); 27 with SMD (-) AN (+); 18 with SMD (-) AN (-), and 10 controls were studied. Both planar and SPECT images were taken at 30 minutes (early) and 3 hours (delayed) after [sup 123]I-MIBG injection. The heart to mediastinum uptake ratio (H/M) and washout ratio of [sup 123]I-MIBG (WR) were obtained from both planar images. Similarly, the difference between the [sup 201]Tl image and the [sup 123]I-MIBG image in the total uptake score (TUS) was taken as the difference in the total uptake score ([Delta]TUS) representing cardiac sympathetic denervation without SMD. On both early and delayed planar images, the mean H/M value in the subgroups of diabetic patients was significantly lower in the SMD (+) AN (+) group than in the control group, but among those subgroups, there was statistically significant difference between the SMD (+) AN (+) and SMD (-) AN (-) groups only on the delayed images. Regarding the WR value, there was no statistically significant difference among subjects. On SPECT image analysis, the diabetic subgroup with AN or SMD had statistically significant lower values for TUS than those of the control group. Among diabetics, there was a statistically significant differences between SMD [+] AN [+] and SMD [-] AN [-] on both early and delayed images. Similarly, the SMD [+] AN [-] group also had significantly lower values than those of SMD [-] AN [-] on early images. Regarding [Delta]TUS, there was a statistically significant differences between AN [+] subgroups and controls. Similarly, the mean value for [Delta]TUS was much higher in AN [+] subgroups than in AN [-] subgroups with or without SMD in diabetes

  17. Exercise testing and thallium-201 myocardial perfusion scintigraphy in the clinical evaluation of patients with Wolff Parkinson White syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Poyatos, M.E.; Suarez, L.; Lerman, J.; Guibourg, H.; Camps, J.; Perosio, A.

    1986-10-01

    In 58 patients with Wolff Parkinson White syndrome (WPW), we performed exercise stress testing in order to investigate the incidence of normalization of the auriculo-ventricular conduction and the ST-segment changes. For a more accurate evaluation of the latter, exercise and redistribution radionuclide images with Thallium-201 were obtained in 18 cases. Forty-nine had type A and nine had type B of WPW. Forty-eight had permanent, four had alternant and six had no pre-excitation (PE) when they started the test. Mean maximal functional capacity, mean maximal heart rate and mean maximal double product were not different when compared to an age-matched control group. Of the 48 patients who began the test with PE, in 23 (48%) it disappeared while PE persisted in 25 (52%). In 16 cases the disappearance of the PE was sudden and in seven it was progressive. Pre-excitation persisted in 39.5% of patients with type A and in 88.8% with type B (p less than 0.01). ST-segment depression was observed in 76.6% of patients with PE and in 28.6% of cases without PE (p less than 0.01). ST-segment depression occurred in 44.8% of patients with type A and in 100% of cases with type B (p less than 0.05). Transient abnormal Thallium-201 scans were observed in 62.5% of patients without PE and in 20% with PE. No patients showed exertional arrhythmias. This study suggests the possibility of measuring the duration of the refractory period of the accessory pathway in those patients n which the PE disappears suddenly, at a given heart rate.

  18. Examination of the findings on {sup 201}Tl, {sup 123}I-BMIPP dual cardiac SPECT in acute phase of Kawasaki disease

    Energy Technology Data Exchange (ETDEWEB)

    Koga, Yutaka [Matsushita-Kotobuki Electronics Industries Ltd., Ohzu, Ehime (Japan); Ishizuka, Takehiro; Otabe, Hiroyuki; Kori, Takeo; Ota, Toshiko; Suzuki, Kazushige

    1999-02-01

    In 42 cases with acute phase of Kawasaki disease (3-27 days since pathopoiesis), {sup 201}Tl, {sup 123}I-BMIPP dual cardiac SPECT was performed and the reduction of the isotope-uptake was macroscopically assessed. On cardiac SPECT, 28 of 42 cases (67%), and 19 of 30 cases (63%) who were normal on electrocardiogram, echocardiogram and blood CK levels showed abnormal images. In a part of cases showing abnormal cardiac SPECT, coronary arteriography was performed, and constrictive lesions with more than 25% were not observed. In acute phase of Kawasaki disease, the risk of cardiac complication was thought to be low. But these results suggest that there are cardiac complications detectable by {sup 201}Tl, {sup 123}I-BMIPP dual cardiac SPECT. This cardiac lesions were thought to be intramyocardinal microangiitis or abnormal coronary micro circulation cased by myocarditis associating microangiitis. (K.H.)

  19. Examination of the findings on [sup 201]Tl, [sup 123]I-BMIPP dual cardiac SPECT in acute phase of Kawasaki disease

    Energy Technology Data Exchange (ETDEWEB)

    Koga, Yutaka (Matsushita-Kotobuki Electronics Industries Ltd., Ohzu, Ehime (Japan)); Ishizuka, Takehiro; Otabe, Hiroyuki; Kori, Takeo; Ota, Toshiko; Suzuki, Kazushige

    1999-02-01

    In 42 cases with acute phase of Kawasaki disease (3-27 days since pathopoiesis), [sup 201]Tl, [sup 123]I-BMIPP dual cardiac SPECT was performed and the reduction of the isotope-uptake was macroscopically assessed. On cardiac SPECT, 28 of 42 cases (67%), and 19 of 30 cases (63%) who were normal on electrocardiogram, echocardiogram and blood CK levels showed abnormal images. In a part of cases showing abnormal cardiac SPECT, coronary arteriography was performed, and constrictive lesions with more than 25% were not observed. In acute phase of Kawasaki disease, the risk of cardiac complication was thought to be low. But these results suggest that there are cardiac complications detectable by [sup 201]Tl, [sup 123]I-BMIPP dual cardiac SPECT. This cardiac lesions were thought to be intramyocardinal microangiitis or abnormal coronary micro circulation cased by myocarditis associating microangiitis. (K.H.)

  20. Analysis of Road Traffic Crashes–Related Maxillofacial Injuries Severity and Concomitant Injuries in 201 Patients Seen at the UCH, Ibadan

    OpenAIRE

    2014-01-01

    The objective of this study was to determine the prevalence of road traffic crashes (RTC)–related maxillofacial injuries, the concomitant injuries occurring with them, and to assess the relationship between the severity of maxillofacial and concomitant injuries. This was a prospective study involving 201 victims of RTC seen at the Accident and Emergency Department of the University College Hospital, Ibadan with maxillofacial injuries during the study period. Demographic data of the patients, ...

  1. SU-C-201-04: Quantification of Perfusion Heterogeneity Based On Texture Analysis for Fully Automatic Detection of Ischemic Deficits From Myocardial Perfusion Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Y [National Cheng Kung University, Tainan, Taiwan (China); Huang, H [Chang Gung University, Taoyuan, Taiwan (China); Su, T [Chang Gung Memorial Hospital, Taoyuan, Taiwan (China)

    2015-06-15

    Purpose: Texture-based quantification of image heterogeneity has been a popular topic for imaging studies in recent years. As previous studies mainly focus on oncological applications, we report our recent efforts of applying such techniques on cardiac perfusion imaging. A fully automated procedure has been developed to perform texture analysis for measuring the image heterogeneity. Clinical data were used to evaluate the preliminary performance of such methods. Methods: Myocardial perfusion images of Thallium-201 scans were collected from 293 patients with suspected coronary artery disease. Each subject underwent a Tl-201 scan and a percutaneous coronary intervention (PCI) within three months. The PCI Result was used as the gold standard of coronary ischemia of more than 70% stenosis. Each Tl-201 scan was spatially normalized to an image template for fully automatic segmentation of the LV. The segmented voxel intensities were then carried into the texture analysis with our open-source software Chang Gung Image Texture Analysis toolbox (CGITA). To evaluate the clinical performance of the image heterogeneity for detecting the coronary stenosis, receiver operating characteristic (ROC) analysis was used to compute the overall accuracy, sensitivity and specificity as well as the area under curve (AUC). Those indices were compared to those obtained from the commercially available semi-automatic software QPS. Results: With the fully automatic procedure to quantify heterogeneity from Tl-201 scans, we were able to achieve a good discrimination with good accuracy (74%), sensitivity (73%), specificity (77%) and AUC of 0.82. Such performance is similar to those obtained from the semi-automatic QPS software that gives a sensitivity of 71% and specificity of 77%. Conclusion: Based on fully automatic procedures of data processing, our preliminary data indicate that the image heterogeneity of myocardial perfusion imaging can provide useful information for automatic determination

  2. Hydrogen Storage Properties of Nanosized MgH2-0.1TiH2 Prepared by Ultrahigh-energy-high-pressure Milling

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Jun; Choi, Young Joon; Fang, Zhigang Zak; Sohn, Hong Yong; Ronnebro, Ewa

    2010-07-29

    Magnesium hydride (MgH2) is an attractive candidate for solid state hydrogen storage applications. To improve the kinetics and thermodynamic properties of MgH2 during dehydrogenation-rehydrogenation cycles, a nano-structured MgH2-0.1TiH2 material system prepared by ultrahigh-energy-high-pressure mechanical milling was investigated. High-resolution TEM and scanning TEM analysis showed that the grain size of the milled MgH2-0.1TiH2 powder is approximately 5-10 nm with uniform distributions of TiH2 among MgH2 particles. Pressure-Composition-Temperature (PCT) analysis demonstrated that both the nanosize and the addition of TiH2 contributed to the significant improvement of the kinetics of dehydrogenation and hydrogenation compared to commercial MgH2. More importantly, PCT cycle analysis demonstrated that the MgH2-0.1TiH2 material system showed excellent cycle stability which is attributed to the inhibition of coarsening by TiH2. The results also showed that the ΔH value for the dehydrogenation of nanostructured MgH2-0.1TiH2 is significantly lower than that of commercial MgH2. However, the ΔS value of the reaction was also lower which results in minimum net effects of the nanosize and the addition of TiH2 on the equilibrium pressure of dehydrogenation reaction of MgH2.

  3. Adsorption kinetics of {sup 201}Tl and migration of {sup 99m}Tc in natural soils; Cinetica de adsorcion de {sup 201}Tl y migracion de {sup 99m}Tc en suelos naturales

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez N, C. E. [Instituto Tecnologico de Toluca, Av. Tecnologico s/n, Fraccionamiento La Virgen, 52149 Metepec, Estado de Mexico (Mexico); Monroy G, F.; Fernandez R, E.; Anguiano A, J., E-mail: estefany_rodriguezn@hotmail.com [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2012-10-15

    The safety is very important in facilities where radioactive wastes are stored. One of the necessary characteristics of the site where these wastes will be disposed is the soil permeability, since a waterproof terrain avoids the diffusion and radionuclide transport in the leakages case. The objective of this work is to study the adsorption kinetics of {sup 201}Tl and the migration of {sup 99m}Tc in natural soil samples. The adsorption kinetics was determined starting from the obtaining of the retention coefficient of the thallium (static method) at different contact times. The technetium diffusion was studied by means of the dynamic method with different soil particles sizes. The results showed that the thallium is totally adsorbed starting from 20 h of contact among this and the mean. On the other hand, the technetium is very mobile in the soil, since it was possible to extract the majority of the tracer with little solvent. Also, it was found that for each soil gram the double water will be needed to leach the technetium almost in its entirety. Moreover, influence exists of the particle size in the migration velocity from the radiotracer to the most mobile being in major sizes than 2 mm that in minor size. (Author)

  4. A study on crosstalk correction in dual energy acquisition of sup 123 I-MIBG and sup 201 TlCl in myocardial SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Onoguchi, Masahisa; Satoh, Keiko; Murata, Hajime; Takao, Yuji; Ohtake, Eiji; Katoh, Kenichi; Saitoh, Kyoko (Toranomon Hospital, Tokyo (Japan)); Toyama, Hinako; Ueno, Takashi

    1991-10-01

    In the simultaneous dual energy acquisition, energy spectrums of two radionuclides crosstalk each other and this phenomenon is a cause of the poor quality of images. In order to obtain the image of high quality in dual energy acquisition of {sup 123}I-MIBG and {sup 201}TlCl, a crosstalk correction method was originated. The crosstalk from {sup 201}Tl to {sup 123}I window (RI) and the crosstalk from {sup 123}I to {sup 201}Tl window (R2) were determined by the cardiac phantom studies. R1 and R2 showed almost constant value throughout the myocardial wall. The crosstalk correction was performed using R1 and R2. After the crosstalk correction, the defect region placed in the cardiac phantom was detected more clearly both in visual interpretation and in quantitative analysis. The crosstalk correction method with R1 and R2 was applied to some clinical cases. By the crosstalk correction, the quality of image was improved and a false defect caused by crosstalk disappeared in a clinical case. The crosstalk correction was considered to be useful for improving the quality of image on dual energy acquisition. (author).

  5. Estimation of infarct size by three-dimensional surface display method of myocardial single photon emission CT with /sup 201/Tl

    Energy Technology Data Exchange (ETDEWEB)

    Kubota, Masahiro; Tsuda, Takatoshi; Akiba, Hidenari; Morita, Kazuo; Hosoba, Minoru; Ban, Ryuichi; Hirano, Takako

    1987-11-01

    To estimate infarct size, we devised three-dimensional (3D) surface display method of /sup 201/Tl myocardial single photon emission CT (SPECT). The method was performed with maximum-count circumferential profiles (CPs) of short axis views of /sup 201/Tl myocardial SPECT. The counts of maximum-count CP were put into a pixel line with the calculated left ventricular circumferential length on each short axis slice. A 3D-surface display map was created by arrangement of these pixel lines from apex to base of left ventricle in order. The sizes of defects in myocardial phantom were calculated by this method. There was a high correlation between the real defect sizes and the calculated defect sizes. In 6 patients with anterior myocardial infarction, the infarct sizes were calculated by this method. The extent of abnormality was identified by automatic computer comparison of each patient's profiles with corresponding lower limits of normal profiles. The infarct sizes calculated by 3D-surface display method were closely correlated not only with the infarct sizes calculated by summation of defect sizes in short axis views, but also with left ventricular ejection fractions. We concluded that the 3D-surface display method of /sup 201/Tl myocardial SPECT is effective for noninvasive assessment of the extent of myocardial infarction.

  6. 19 CFR 201.201 - Definitions.

    Science.gov (United States)

    2010-04-01

    ...) Normal life insurance premiums (e.g., Serviceman's Group Life Insurance and “Basic Life” Federal Employee's Group Life Insurance premiums), not including amounts deducted for supplementary coverage. (h... presents evidence of a tax obligation supporting the additional withholding; (6) Health insurance...

  7. Evaluation of myocardial disorders in patients with dilated cardiomyopathy and left ventricular eccentric hypertrophy; By sup 201 Tl myocardial SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Yamazaki, Junichi; Ohsawa, Hidefumi; Uchi, Takashi (Toho Univ., Tokyo (Japan). School of Medicine) (and others)

    1992-03-01

    {sup 201}Tl myocardial SPECT was performed in cases of dilated cardiomyopathy and valvular heart disease with left ventricular eccentric hypertrophy, and the two groups were compared from the standpoint of the mechanism of onset of myocardial disorders. Significant coefficients of correlation were seen between the Tl score and LVDd (r=0.792, r=0.785) and Tl score and LVEF (r=-0.634, r=-0.555) in both dilated cardiomyopathy and valvular heart disease. In cases of valvular heart disease, significant correlation coefficients (r=-0.756, r=-0.720) between LVDd and r-WR (relative-washout rate), and Tl score and r-WR were observed, but no such correlation was seen in dilated cardiomyopathy. In valvular heart disease, a decrease in myocardial perfusion associated with enlargement of the left ventricle appeared, while in dilated cardiomyopathy, there was a marked decrease in LVEF in proportion to the thallium defect. Therefore, it was assumed that left ventricular wall disorders occur due to myocardial metabolic disorders and coronary microcirculation disorders. (author).

  8. An investigation on microstructure and mechanical propertiesof a Nb-microalloyed nano/ultrafine grained 201 austenitic stainless steel

    Energy Technology Data Exchange (ETDEWEB)

    Samaei Baghbadorani, H., E-mail: h.samaeibaghbadorani@ma.iut.ac.ir [Department of Materials Engineering, Isfahan University of Technology, 84156-83111 Isfahan (Iran, Islamic Republic of); Kermanpur, A. [Department of Materials Engineering, Isfahan University of Technology, 84156-83111 Isfahan (Iran, Islamic Republic of); Najafizadeh, A. [Department of Materials Engineering, Isfahan University of Technology, 84156-83111 Isfahan (Iran, Islamic Republic of); Fould Institute of Technology, Fouldshare 84916-63763 (Iran, Islamic Republic of); Behjati, P.; Rezaee, A.; Moallemi, M. [Department of Materials Engineering, Isfahan University of Technology, 84156-83111 Isfahan (Iran, Islamic Republic of)

    2015-06-11

    The present study was aimed to investigate the mechanical properties of a nano/ultrafine grained Nb-containing 201 austenitic stainless steel. For this purpose, 90% cold rolled sheets with fully martensitic microstructure were isothermally annealed at 900 °C for different times of 1 to 1800 s, leading to the reversion of strain- induced α′-martensite to austenite and significant grain refinement. Ferritescopy, X-ray diffractometery and optical/electron microscopy techniques along with hardness measurements and tensile tests were used to study the evolution in microstructure and mechanical properties in the course of annealing. It was found that heavy cold-rolling promoted formation of Nb-rich carbonitrides which effectively retarded the growth of fine reverted austenite grains. The obtained results showed that the complete transformation of martensite to austenite took about 60 s with the corresponding austenite grain size of about 90 nm. This sample had an ultrahigh yield strength of 1170 MPa, which was almost four times higher than that of the raw material and outstanding elongation of 37%. Further, the true stress–strain curves of the reversion annealed samples revealed two distinct uniform elongation stages (stage I and stage II), whereas, the onset of stage II was concurrent with pronounced strain hardening. This was related to the sharp increase in the formation of α′-martensite upon tensile straining.

  9. Correlation between dobutamine stress transesophageal echocardiography, thallium 201-dipyridamole scintigraphy and coronary angiography in the early detection of myocardial ischemia.

    Science.gov (United States)

    Rosas-Munive, E; Abundes-Velasco, A; Villa-Godínez, G; López-Winter, J F

    1996-01-01

    In order to establish the sensitivity and specificity of transesophageal stress echocardiography with dobutamine (TEE-dobutamine) in the early detection of myocardial ischemia we studied 30 consecutive patients from the Coronary Care Unit (CCU) of the Hospital de Cardiología, Centro Médico Nacional Siglo XXI. The results were correlated with thallium-201-dipyridamole scintigraphy (TDS), and coronary angiography. Two groups were formed: Group I-20 patients, 18 females/2 males, aged 37-73 years (mean 55 years) within the first week of myocardial infarction and/or unstable angina; Group II-10 patients, five males/five females, aged 35-65 years (mean 48 years) with atypical chest pain but with high suspicion of CHD. All group I patients, and none of group II, had significant stenoses on coronary angiography. Twenty patients had a positive TDS (18 patients from group I and two from group II). Twenty one patients had a positive test with TEE-dobutamine, 20 from group I and one from group II, which yields a sensitivity of 100%, a specificity of 90%, positive predictive value of 95% and negative predictive value of 100%.

  10. Differential anatomical expression of ganglioside GM1 species containing d18:1 or d20:1 sphingosine detected by MALDI Imaging Mass Spectrometry in mature rat brain

    Directory of Open Access Journals (Sweden)

    Nina eWeishaupt

    2015-12-01

    Full Text Available GM1 ganglioside plays a role in essential neuronal processes, including differentiation, survival and signaling. Yet, little is known about GM1 species with different sphingosine bases, such as the most abundant species containing 18 carbon atoms in the sphingosine chain (GM1d18:1, and the less abundant containing 20 carbon atoms (GM1d20:1. While absent in the early fetal brain, GM1d20:1 continues to increase throughout pre- and postnatal development and into old age, raising questions about the functional relevance of the GM1d18:1 to GM1d20:1 ratio. Matrix-assisted laser desorption/ionization (MALDI Imaging Mass Spectrometry is a novel technology that allows differentiation between these two GM1 species and quantification of their expression within an anatomical context. Using this technology, we find GM1d18:1/d20:1 expression ratios are highly specific to defined anatomical brain regions in adult rats. Thus, the ratio was significantly different among different thalamic nuclei and between the corpus callosum and internal capsule. Differential GM1d18:1/GM1d20:1 ratios measured in hippocampal subregions in rat brain complement previous studies conducted in mice. Across layers of the sensory cortex, opposing expression gradients were found for GM1d18:1 and GM1d20:1. Superficial layers demonstrated lower GM1d18:1 and higher GM1d20:1 signal than other layers, while in deep layers GM1d18:1 expression was relatively high and GM1d20:1 expression low. By far the highest GM1d18:1/d20:1 ratio was found in the amygdala. Differential expression of GM1 with d18:1- or d20:1-sphingosine bases in the adult rat brain suggests tight regulation of expression and points toward a distinct functional relevance for each of these GM1 species in neuronal processes.

  11. Non-occupational Carbon Monoxide Poisoning:Analysis of 201 Incidents%非职业性一氧化碳中毒201起事件分析

    Institute of Scientific and Technical Information of China (English)

    钱旭东; 高金鑫

    2011-01-01

    [ Objective] To analyze the basic features of non-occupational carbon monoxide poisoning, and explore the effective prevention and control measures. [ Methods] Descriptive analysis was performed on 201 incidents of non-occupational carbon monoxide poisoning reported from November 1st, 2009 - October 31st, 2010 in a district of Beijing City. [ Results] Non-occupational carbon monoxide poisoning occurred frequently in winter heating period( 81.6% )and the rurban areas( 55.2% ), with the peak in January 2010(38.3% ). 98.5% occurred in family, 94.0% due to improper use of coal-fired heating with 260 poisoned cases, the young and middle-aged (41.2%), women (54.2%) were the major, 52.7% were sent to emergency centre with hyperbaric oxygen therapy condition. [ Conclusion ] Only strengthening health education about carbon monoxide poisoning knowledge, improving safety awareness, emphasizing the importance of indoor ventilation, correct use of stove, gas water heaters and other heating facilities, can effectively prevent non-occupational carbon monoxide poisoning. Once discovering carbon monoxide poisoning patients, they should be sent to medical institutions with hyperbaric oxygen therapy condition as soon as possible.%目的:分析非职业性一氧化碳中毒事件的基本特征,探讨有效预防和控制措施.方法:对北京市某区2009年11月1日-2010年10月31日报告的201起非职业性一氧化碳中毒事件进行描述性分析.结果:非职业性一氧化碳中毒事件在冬季采暖期(81.6%)和城乡接合部(55.2%)高发,2010年1月为高峰期(38.3%),98.5%发生在家庭,94.0%由于燃煤取暖使用不当引起;中毒患者260人,以20-39岁的青壮年(41.2%)、女性(54.2%)居多,52.7%送往有高压氧治疗条件的急救中心救治.结论:只有加强预防一氧化碳中毒知识的健康宣教工作,提高安全防范意识,强调室内通风的重要性,正确使用煤炉、燃气热水器等采暖

  12. Novel degenerate PCR method for whole genome amplification applied to Peru Margin (ODP Leg 201 subsurface samples

    Directory of Open Access Journals (Sweden)

    Amanda eMartino

    2012-01-01

    Full Text Available A degenerate PCR-based method of whole-genome amplification, designed to work fluidly with 454 sequencing technology, was developed and tested for use on deep marine subsurface DNA samples. The method, which we have called Random Amplification Metagenomic PCR (RAMP, involves the use of specific primers from Roche 454 amplicon sequencing, modified by the addition of a degenerate region at the 3’ end. It utilizes a PCR reaction, which resulted in no amplification from blanks, even after 50 cycles of PCR. After efforts to optimize experimental conditions, the method was tested with DNA extracted from cultured E. coli cells, and genome coverage was estimated after sequencing on three different occasions. Coverage did not vary greatly with the different experimental conditions tested, and was around 62% with a sequencing effort equivalent to a theoretical genome coverage of 14.10X. The GC content of the sequenced amplification product was within 2% of the predicted values for this strain of E. coli. The method was also applied to DNA extracted from marine subsurface samples from ODP Leg 201 site 1229 (Peru Margin, and results of a taxonomic analysis revealed microbial communities dominated by Proteobacteria, Chloroflexi, Firmicutes, Euryarchaeota, and Crenarchaeota, among others. These results were similar to those obtained previously for those samples; however, variations in the proportions of taxa show that community analysis can be sensitive to both the amplification technique used and the method of assigning sequences to taxonomic groups. Overall, we find that RAMP represents a valid methodology for amplifying metagenomes from low biomass samples.

  13. Comparison of Massimo Pronto-7 and HemoCue Hb 201+ with laboratory haemoglobin estimation: a clinical study.

    Science.gov (United States)

    Hiscock, R; Simmons, Sw; Carstensen, B; Gurrin, Lc

    2014-09-01

    We prospectively studied agreement in haemoglobin estimation between two point-of-care devices (Pronto-7(®) Pulse CO-Oximetry(™), Masimo Corporation, Irvine, California, USA and HemoCue(®) Hb 201 +, HemoCue, Angelholm, Sweden) and an automated laboratory analyser (Sysmex XE5000, Sysmex Corporation, Kobe, Japan). Venous blood sampling and finger co-oximeter readings were performed on 141 pregnant women undergoing routine mid-trimester haemoglobin assessment. Three replicate measures were performed and analysis used Bayesian-based variance component modelling to provide estimates of repeatability, between person within method bias and precision. Repeatability, assessed by coefficient of variation, was higher for Pronto-7(®) (2.3%) compared to HemoCue(®) (5.2%). Fixed bias (mean difference, device - laboratory) was +1.18 (standard deviation 1.19) g/dl and - 0.01 (standard deviation 1.34) g/dl for Pronto-7(®) and HemoCue(®) respectively, with no statistical evidence of proportional bias. Based upon a single device reading, the 95% prediction limits for Pronto-7(®) were -1.2 to 3.6 g.dl-1 and HemoCue(®) were -2.7 to 2.7 g/dl. For both devices precision was not meaningfully improved by averaging replicate readings. However, repeated readings may allow detection of aberrant results. Overall both devices are imprecise and 95% prediction limits wide. We present further prediction limits, derived from the posterior distribution and adjusted for any fixed bias for set levels of probability (certainty). These may be used to support clinical decisions when using these point-of-care devices.

  14. Activity measurements of the radionuclide {sup 201}Tl for the L.N.E.-L.N.H.B., France, P.T.B., Germany and the N.P.L., UK in the ongoing comparison B.I.P.M..R.I.(2)-K1.TI-201

    Energy Technology Data Exchange (ETDEWEB)

    Ratel, G.; Michotte, C. [Bureau International des Poids et Mesures (BIPM), 92 - Sevres (France); Moune, M.; Bobin, C. [CEA Saclay, Laboratoire National Henri Becquer (LNE-LNHB), 91 - Gif sur Yvette (France); Kossert, K. [Physikalisch-Technischen Bundesanstalt (PTB) (Germany); Johansson, L. [National Physical Laboratory (NPL) (United Kingdom)

    2008-08-15

    In 2005, the Laboratoire national de metrologie et essais- Laboratoire national Henri becquerel (L.N.E.- L.N.H.B.) and the Physikalisch-technische bundesanstalt (P.T.B.) each submitted a sample of known activity of {sup 201}Tl to the International reference system (S.I.R.). In 2006, the National physical laboratory (N.P.L.) submitted their first sample. The range of values of the activity submitted was between 2 MBq and 63 MBq. These key comparison results have been included in the re-evaluated key comparison reference value and replaced the previous results for france and Germany in the matrix of degrees of equivalence in the key comparison database that now contains seven results, identifier B.I.P.M..R.I.(2)-KI.Tl-201. (authors)

  15. Pulmonary uptake of thallium-201 in patients with congenital heart disease; Comparison between total anomalous pulmonary venous connection and tetralogy of Fallot

    Energy Technology Data Exchange (ETDEWEB)

    Kohata, Tohru; Ono, Yasuo; Iwatani, Hajime; Fukushima, Hideki; Kamiya, Tetsuro; Yagihara, Toshikatsu; Nishimura, Tsunehiko; Takamiya, Makoto (National Cardiovascular Center, Suita, Osaka (Japan))

    1992-01-01

    To evaluate the pulmonary extravascular space in patients with congenital heart disease, lung uptake of Tl-201 was quantitatively studied. Patients' diseases consisted of total anomalous pulmonary venous connection (TAPVC)--supracardiac (I), paracardiac (II) and infracardiac (III) types--, tetralogy of Fallot (T/F), ventricular septal defect (VSD), and patent ductus arteriosus (PDA). Tl-201 imaging was performed before operation and in the early and late stages after operation. Twenty-five other patients with arrhythemias or a history of Kawasaki disease without perfusion defects served as controls. Lung uptake of Tl-201 was analyzed with a computer using the anterior image of the chest, and the averge count ratio of the right lung (P) to the left ventricular wall (LV) was calculated. P/LV values were compared between the patients before and after operation, and differences in anatomical types in TAPVC were also evaluated. In TAPVC, P/LV values decreased gradually after operation, but were significantly higher than those of controls even in the late stage. In the late stage after operation, type I TAPVC had significantly higher P/LV values than those of type-II. In T/F, the P/LV values were significantly higher after operation, even in the late stage, than before operation. In the VSD or PDA group, the P/LV value returned to normal after operation and was significantly lower than that before operation. In conclusion, TAPVC patients was considered to have a larger pulmonary extravascular space even in the late stage after operation, suggesting a sign of pulmonary congestion due to intrapulmonary vascular damage in utero. In T/F, scanty pulmonary vascular beds before operation were perfused with increased pulmonary blood flow after operation. Therefore, postoperative increases in pulmonary blood flow may be responsible for the increased pulmonary extravascular space. (N.K.).

  16. Cost-effectiveness of exercise {sup 201}Tl myocardial SPECT in patients with chest pain assessed by decision-tree analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kosuda, Shigeru; Momiyama, Yukihiko; Ohsuzu, Fumitaka; Kusano, Shoichi [National Defense Medical Coll., Tokorozawa, Saitama (Japan); Ichihara, Kiyoshi

    1999-09-01

    To evaluate the potential cost-effectiveness of exercise {sup 201}Tl myocardial SPECT in outpatients with angina-like chest pain, we developed a decision-tree model which comprises three 1000-patients groups, i.e., a coronary arteriography (CAG) group, a follow-up group, and a SPECT group, and total cost and cardiac events, including cardiac deaths, were calculated. Variables used for the decision-tree analysis were obtained from references and the data available at out hospital. The sensitivity and specificity of {sup 201}Tl SPECT for diagnosing angina pectoris, and its prevalence were assumed to be 95%, 85%, and 33%, respectively. The mean costs were 84.9 x 10{sup 4} yen/patient in the CAG group, 30.2 x 10{sup 4} yen/patient in the follow-up group, and 71.0 x 10{sup 4} yen/patient in the SPECT group. The numbers of cardiac events and cardiac deaths were 56 and 15, respectively in the CAG group, 264 and 81 in the follow-up group, and 65 and 17 in the SPECT group. SPECT increases cardiac events and cardiac deaths by 0.9% and 0.2%, but it reduces the number of CAG studies by 50.3%, and saves 13.8 x 10{sup 4} yen/patient, as compared to the CAG group. In conclusion, the exercise {sup 201}Tl myocardial SPECT strategy for patients with chest pain has the potential to reduce health care costs in Japan. (author)

  17. Clinical studies on thallium-201 myocardial single-photon emission computed tomography in patients with ischemic heart disease. Clinical evaluation using the polar map method

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Naohiko

    1987-06-01

    In order to evaluate briefly the relative 3-dimensional distribution of /sup 201/Tl in the myocardium, a 2-dimensional polar map was developed from short axis tomograms of single-photon emission computed tomography (SPECT) using circumferential profile analysis. The data collected from 180 deg rotational scan around a body were used in clinical study to acquire the projection data in a short time, although, with a heart phantom study, there was more uniformity with the 360 deg collection than with 180 deg collection. So, the polar map of relative distribution and % washout rate (% WR) were created from 180 deg data collection. To detect ischemic area, the lower limit (M-SD) of the profile curve in 10 normal subjects was processed and compared with that of patients. Then, abnormal /sup 201/Tl distribution and % WR were identified comparing each patient's profile with the corresponding normal lower limits. In 24 patients with myocardial infarction, defect score (DS), estimated as infarcted size from the relative polar map, was compared with the size of abnormal wall motion in left ventriculography. There was a good correlation (r = 0.834) between them. Also, there were close correlations between DS and regional contraction (r = -0.869), and between DS and left ventricular ejection fraction (r = -0.775) respectively. In 24 patients with non-MI angina pectoris, the diagnostic sensitivity of exercise induced ischemia was 65 % and accuracy was 76 % by relative distribution map. However, the sensitivity of % WR map was superior (84 %) to that of relative map, especially in the patients with mild ischemia and multi-vessel disease. In conclusion, this comprehensive polar map method represented well a 3-dimensional myocardial distribution of /sup 201/Tl. The clinical usefulness in determination of infarct size and in diagnosis of myocardial ischemia were evaluated.

  18. Application of JL-201 bearing failure diagnostic instrument to detection analysis of traction motor%JL-201机车车辆轴承故障诊断仪在牵引电动机检测分析中的应用

    Institute of Scientific and Technical Information of China (English)

    魏静姿

    2008-01-01

    JL-201机车车辆轴承故障诊断仪的检测原理,并通过实验确定出DF4B型机车牵引电动机自由端轴承门限值范围.采用修正后的门限值与精密诊断的分析判断方法,提高了检测的准确率.

  19. Microvascular obstruction on delayed enhancement cardiac magnetic resonance imaging after acute myocardial infarction, compared with myocardial {sup 201}Tl and {sup 123}I-BMIPP dual SPECT findings

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Hiroaki [Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya (Japan); Department of Cardiology, Kainan Hospital, Yatomi (Japan); Isobe, Satoshi, E-mail: sisobe@med.nagoya-u.ac.jp [Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya (Japan); Sakai, Shinichi [Department of Cardiology, Kainan Hospital, Yatomi (Japan); Yamada, Takashi [Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya (Japan); Watanabe, Naoki; Miura, Manabu [Department of Cardiology, Kainan Hospital, Yatomi (Japan); Uchida, Yasuhiro; Kanashiro, Masaaki; Ichimiya, Satoshi [Department of Cardiology, Yokkaichi Municipal Hospital, Yokkaichi (Japan); Okumura, Takahiro; Murohara, Toyoaki [Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya (Japan)

    2015-08-15

    Highlights: • The percentage infarct size (%IS) was significantly greater in the microvascular obstruction (MO) group than in the non-MO group. • The percentage mismatch score (%MMS) on dual scintigraphy significantly correlated with the %IS and the percentage MO. • The %MMS was significantly greater in the non-MO group than in the MO group, and was an independent predictor for MO. - Abstract: Background: The hypo-enhanced regions within the hyper-enhanced infarct areas detected by cardiac magnetic resonance (CMR) imaging reflect microvascular obstruction (MO) after acute myocardial infarction (AMI). The combined myocardial thallium-201 ({sup 201}Tl)/iodine-123-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid ({sup 123}I-BMIPP) dual single-photon emission computed tomography (SPECT) is a useful tool for detecting myocardial reversibility after AMI. We evaluated whether MO could be an early predictor of irreversible myocardial damage in comparison with {sup 201}Tl and {sup 123}I-BMIPP dual SPECT findings in AMI patients. Methods: Sixty-two patients with initial AMI who successfully underwent coronary revascularization were enrolled. MO was defined by CMR imaging. Patients were divided into 2 groups as follows: MO group (n = 32) and non-MO group (n = 30). Scintigraphic defect scores were calculated using a 17-segment model with a 5-point scoring system. The mismatch score (MMS) was calculated as follows: the total sum of (Σ) {sup 123}I-BMIPP defect score minus Σ{sup 201}Tl defect score. The percentage mismatch score (%MMS) was calculated as follows: MMS/(Σ{sup 123}I-BMIPP score) × 100 (%). Results: The percentage infarct size (%IS) was significantly greater in the MO group than in the non-MO group (32.2 ± 13.8% vs. 18.3 ± 12.1%, p < 0.001). The %MMS significantly correlated with the %IS and the percentage MO (r = −0.26, p = 0.03; r = −0.45, p < 0.001, respectively). The %MMS was significantly greater in the non-MO group than in the MO group (45.4

  20. BINARY AND TERNARY ION EXCHANGE KINETICS SO42——Cl——NO3——201×7SYSTEM

    Institute of Scientific and Technical Information of China (English)

    TAOZuyi; ZHOUHaimei; 等

    1993-01-01

    Kinetics of chloride/sulfate,chloride/nitrate and nitrate/sulfate forward exchanges and reverse exchanges at solution concentrations of 1N,0.2N and 0.02 N on 201×7 strong base anion exchange resin,respectively,have been examined at 25℃.It is found that the forward and the reverse exchange rates of the two given ions at low solution concentration,respectively,under identical conditions can be controlled by different mechanisms,while those at high solution concentration are all controlled by particle diffusion.The ternary exchange rates of sulfate/(chloride+nitrate) and nitrate/(chloride+sulfate)have also been examined.