WorldWideScience

Sample records for assisting type regional

  1. Regional Legal Assistance

    Directory of Open Access Journals (Sweden)

    Abdul Fatah

    2015-06-01

    Full Text Available Legal aid policy in the area carried out on several considerations including: Implementation of the authority given to the legal aid act, granting the guarantee and protection of access to justice and equality before the law in the area, equitable distribution of justice and increase public awareness and understanding of the law, and legal implications that accompanied the emergence of the right to legal counsel without pay and the right to choose the legal settlement. How To Cite Fatah, A. (2015. Regional Legal Assistance. Rechtsidee, 2(1, 1-10. doi:http://dx.doi.org/10.21070/jihr.v2i1.7

  2. Gain assisted multiple surperluminal regions via a Kerr nonlinearity in a double lambda-type atomic configuration

    International Nuclear Information System (INIS)

    Bacha, Bakht Amin; Ghafoor, Fazal; Ahmad, Iftikhar; Rahman, A

    2014-01-01

    A four level double lambda-type atomic configuration is extended to polychromatic pump fields driven from the ground to the same excited hyperfine sublevel. Multiple superluminal regions are observed in the gain peak regions and between the two pairs of gain peak regions. Furthermore, the effect of cross Kerr nonlinearity is introduced in the system by applying an additional driving field. Large enhancement in the superluminality is observed as compared to the previously observed superluminality without the Kerr nonlinearity. The results clearly show a small negative group velocity of − 0.72 m s −1 with a negative time delay of −42.2 ms in the presence of the Kerr field. In this connection, useful theoretical techniques are presented for the enhancement of slow and fast light propagation. This generalized model is adjustable with the current applied technologies of cloaking devices and spacial mode images. (paper)

  3. Radiological Assistance Program (RAP) Regions

    Data.gov (United States)

    Department of Homeland Security — The U.S. Department of Energy (DOE) created the Radiological Assistance Program (RAP) in the 1950s to make DOE resources and expertise available to organizations...

  4. Radiological assistance program: Region I. Part I

    International Nuclear Information System (INIS)

    Musolino, S.V.; Kuehner, A.V.; Hull, A.P.

    1985-01-01

    The purpose of the Radiological Assistance Program (RAP) is to make DOE resources available and provide emergency assistance to state and local agencies in order to control radiological hazards, protect the public health and safety, and minimize the loss of property. This plan is an integral part of a nationwide program of radiological assistance established by the US DOE, and is implemented on a regional basis. The Brookhaven Area Office (BHO) Radiological Assistance Program is applicable to DOE Region I, which consists of the New England States, New York, New Jersey, Pennsylvania, Delaware, Maryland and the District of Columbia. The BHO RAP-1 has been developed to: (a) ensure the availability of an effective radiological assistance capability to ensure the protection of persons and property; (b) provide guidelines to RAP-1 Team personnel for the evaluation of radiological incidents and implementation of corrective actions; (c) maintain liaison with other DOE installations, Federal, State and local organizations which may become involved in radiological assistance operations in Region I; and (d) encourage development of a local capability to cope with radiological incidents

  5. Assistance Focus: Asia/Pacific Region

    Energy Technology Data Exchange (ETDEWEB)

    2017-03-29

    The Clean Energy Solutions Center, an initiative of the Clean Energy Ministerial, helps countries throughout the world create policies and programs that advance the deployment of clean energy technologies. Through the Solutions Center's no-cost 'Ask an Expert' service, a team of international experts has delivered assistance to countries in all regions of the world. High-impact examples from the Asia/Pacific region are featured here.

  6. Assistance Focus: Asia/Pacific Region

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-22

    The Clean Energy Solutions Center, an initiative of the Clean Energy Ministerial, helps countries throughout the world create policies and programs that advance the deployment of clean energy technologies. Through the Solutions Center's no-cost 'Ask an Expert' service, a team of international experts has delivered assistance to countries in all regions of the world, including nearly 30 countries in the Asia/Pacific region. This document highlights a few examples of the Solutions Center's work in the region.

  7. Region 8 radiological assistance program team response manual

    International Nuclear Information System (INIS)

    Webb, D.E.

    1997-01-01

    The purpose of this manual is to provide guidance so that a request for radiological assistance is responded to in an effective and consistent manner. These procedures are specific to the trained and qualified members of the Region 8 Radiological Assistance Program (RAP) team. Procedures provide steps for responding to the request, notification and activation of the team members, position descriptions, and checklists

  8. DOE Region 6 Radiological Assistance Program plan. Revision 1

    International Nuclear Information System (INIS)

    Jakubowski, F.M.

    1995-11-01

    The US Department of Energy (DOE) has sponsored a Radiological Assistance Program (RAP) since the 1950's. The RAP is designed to make DOE resources available to other DOE facilities, state, tribal, local, private businesses, and individuals for the explicit purpose of assisting during radiological incidents. The DOE has an obligation, through the Atomic Energy Act of 1954, as amended, to provide resources through the Federal Radiological Emergency Response Plan (FRERP, Nov. 1985) in the event of a radiological incident. Toward this end, the RAP program is implemented on a regional basis, and has planned for an incremental response capability with regional coordination between states and DOE response elements. This regional coordination is intended to foster a working relationship between DOE radiological assistance elements and those state, tribal, and local agencies responsible for first response to protect public health and safety

  9. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Core industry creation type. Thermoelectric energy recovery system for automobile; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Jidoshayo netsuden energy kaishu system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The project aims to develop a system for recovering heat from the thermal energy of automobile exhaust in the form of electric energy. Skutterudite based thermoelectric materials for high temperature use and existing thermoelectric materials for low/middle temperature use were improved in performance, and a dimensionless thermoelectric performance index of ZT=1 was attained. Advanced processes were applied for improvement on the performance of existing thermoelectric materials. In the effort to develop technologies for the mass production of thermoelectric materials for high temperature use, a material manufacturing process was established for manufacturing materials excellent in thermoelectric and mechanical properties using a method for mass-producing sinterable materials by gas atomization and a large discharge plasma sintering process capable of treating large specimens. In the effort to improve automobile power generation modules in performance and to establish element technologies for their manufacture, technologies were developed involving thermoelectric materials and electrodes, bonding of different thermoelectric materials, bonding of heat conducting electrical insulators and electrodes, and high efficiency segment type power generation modules. A high performance automobile exhaust gas heat exchanger was developed. A Co-Sb based thermoelectric module and a Bi-Te based module were combined and the package was tested aboard automobiles, when a maximum power output of 83W was achieved. It is necessary to review module arrangement. (NEDO)

  10. Leading or Managing? Assistant Regional Directors, School Performance, in Queensland

    Science.gov (United States)

    Bloxham, Ray; Ehrich, Lisa C.; Iyer, Radha

    2015-01-01

    Purpose: Education reform aimed at achieving improved student learning is a demanding challenge for leaders and managers at all levels of education across the globe. In 2010, the position of Assistant Regional Directors, School Performance (ARD-SP), was established to positively impact upon student learning across public schools in Queensland,…

  11. Assistance Focus: Latin America and the Caribbean Region

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-17

    The Clean Energy Solutions Center, an initiative of the Clean Energy Ministerial, helps countries throughout the world create policies and programs that advance the deployment of clean energy technologies. Through the Solutions Center's no-cost Ask an Expert service, a team of international experts has delivered assistance to countries in all regions of the world, including Latin America and the Caribbean.

  12. Design of wheel-type walking-assist device

    International Nuclear Information System (INIS)

    Jung, Seung Ho; Kim, Seung Ho; Kim, Chang Hoi; Seo, Yong Chil; Jung, Kyung Min; Lee, Sung Uk

    2006-03-01

    In this research, a outdoor wheel-type walking-assist device is developed to help an elder having a poor muscular strength at legs for walking, sitting and standing up easily at outdoors, and also for going and downing stairs. In conceptually designing, the environments of an elder's activity, the size of an elder's body and a necessary function of helping an elder are considered. This device has 4 wheels for stability. When an elder walks in incline plane with the proposed device, a rear-wing is rotated to keep the supporting device horizontal, regardless of an angle of inclination. A height-controlling device, which can control the height of the supporting device for adjusting an elder's height, is varied vertically to help an elder to sit and stand-up easily. Moreover, a outdoor wheel-type walking-assist device is conceptually designed and is made. In order to design it, the preview research is investigated firstly. On the basis of the proposed walking-assist device, the outdoor walking-assist device is designed and made. The outdoor wheel-type walking-assist device can go and down stairs automatically. This device go up and down the stair of having maximum 20cm height and an angle of 25 degrees with maximum 4 sec/stairs speed, and move at flatland with 60cm/sec speed

  13. Assisted outpatient treatment in New York: regional differences in New York's assisted outpatient treatment program.

    Science.gov (United States)

    Robbins, Pamela Clark; Keator, Karli J; Steadman, Henry J; Swanson, Jeffrey W; Wilder, Christine M; Swartz, Marvin S

    2010-10-01

    This study sought to describe the implementation of "Kendra's Law" in New York State and examine regional differences in the application of the program. Between February 2007 and April 2008, interviews were conducted with 50 key informants across New York State. Key informants included assisted outpatient treatment (AOT) county coordinators, county directors of community services, judges, attorneys from the Mental Hygiene Legal Service (MHLS), psychiatrists, treatment providers, peer advocates, family members, and other referred individuals. Additional analyses were conducted using AOT program administrative and evaluation databases and client history data. From program inception in 1999 through 2007, a total of 8,752 initial AOT orders and 5,684 renewals were granted. Notable regional differences were found in the use of two distinct models of AOT: AOT First and Enhanced Voluntary Services First. Regional differences were also found in how the AOT program was implemented and administered. Other variations stemmed from the court proceedings themselves, the continuity and interest of the presiding judge, and the attitudes of the MHLS attorneys. Many regional adaptations of the AOT program were found. Many were the result of lack of guidance in implementing Kendra's Law. Policy makers may want to consider whether the law should change to allow for these differences or whether additional support from a central source is warranted to ensure more uniformity in the implementation of AOT and thus the fairness of its application across the state.

  14. 13 CFR 127.101 - What type of assistance is available under this part?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What type of assistance is available under this part? 127.101 Section 127.101 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION WOMEN-OWNED SMALL BUSINESS FEDERAL CONTRACT ASSISTANCE PROCEDURES General Provisions § 127.101...

  15. Radiological Assistance Program, DOE Region 6 response plan

    International Nuclear Information System (INIS)

    Jakubowski, F.M.

    1993-02-01

    This program plan meets all the requirements identified in DOE Order 5530.3, Radiological Assistance Program and supports those requirements leading to the establishment of a Federal Radiological Monitoring and Assessment Center (FRMAC) as required by DOE 5530-5. Requests for radiological assistance may come from other DOE facilities, Federal or state agencies, tribal officials, or from any private corporation or individual. Many of the requests will be handled by a telephone call, a conference or a letter, teletype or memorandum. Other requests for assistance may involve radioactive material in serious accidents, fire, personal injuries, contamination or possible hazards to the general public. Some occurrences may require the dispatch of trained personnel equipped with radiation monitoring instruments and related equipment necessary to evaluate, control and neutralize the hazard. The primary responsibility for incidents involving radioactive material always remains with the party having custody of the radioactive materials. In addition, the DOE recognizes that the assistance provided shall not in any way preempt state, tribal, or local authority and/or responsibility on state or tribal properties. Toward this end, DOE assistance for non-DOE radioactive materials, is limited to technical assistance, advice, measurement and other resources as deemed necessary by the local authorities but excludes DOE interface with the public media. This is a function handled by the local or state Incident Commander

  16. U.S. Department of Energy Region 6 Radiological Assistance Program response plan. Revision 2

    International Nuclear Information System (INIS)

    Jakubowski, F.M.

    1998-02-01

    Upon request, the DOE, through the Radiological Assistance Program (RAP), makes available and will provide radiological advice, monitoring, and assessment activities during radiological incidents where the release of radioactive materials is suspected or has occurred. Assistance will end when the need for such assistance is over, or if there are other resources available to adequately address the incident. The implementation of the RAP is usually accomplished through the recommendation of the DOE Regional Coordinating Office's (RCO) on duty Regional Response Coordinator (RRC) with the approval of the Regional Coordinating Office Director (RCOD). The DOE Idaho Operations Office (DOE-ID) is the designated RCO for DOE Region 6 RAP. The purpose of this document is: to describe the mechanism for responding to any organization or private citizen requesting assistance to radiological incidents; to coordinate radiological assistance among participating federal agencies, states, and tribes in DOE Region 6; and to describe the RAP Scaled Response concept of operations

  17. Fiscal 2000 achievement report on the venture business assisting type regional consortium-Core industry creation type. Development of radiation detector utilizing surface reforming effect of irradiation; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Hoshasen shosha ni yoru hyomen kaishitsu koka wo mochiita hoshasen kenshutsuki no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    It has been clarified that the use of some kinds of semiconductor films, such as a rutile type titanium oxide film or a zirconium oxide film, results in a stable photocatalytic reaction in an intensive radioactivity region. In this effort, the effect is applied for the development of a FET (field effect transistor) type radiation detector capable of stable operation under high dose irradiation circumstances. Semiconductor materials such as a rutile type titanium oxide were subjected to irradiation tests on the ground, in which changes in their physical properties such as wettability or conductance were examined and the mechanism of surface reforming under irradiation was elucidated, and proper materials were selected. A prototype high radiation detector was fabricated that covers a 1mGy/hr-4kGy/hr region. For the establishment of a technology for growing spherical semiconductor crystals under microgravity, basic experiments were conducted using a free-fall facility at the Japan Microgravity Center. Basic experiments were conducted for the fabrication of a prototype radiation detector to operate in a high radiation region from 0.1kGy/hr to 2kGy/hr and beyond, and a prototype spherical semiconductor radiation detector was fabricated. Achievements of the effort are mentioned above. (NEDO)

  18. 13 CFR 124.702 - What types of assistance are available through the 7(j) program?

    Science.gov (United States)

    2010-01-01

    ..., marketing, and operation of small business concerns; and (b) The identification and development of new... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What types of assistance are available through the 7(j) program? 124.702 Section 124.702 Business Credit and Assistance SMALL BUSINESS...

  19. ABOUT THE TYPES OF REGIONAL INNOVATION CLUSTERS

    Directory of Open Access Journals (Sweden)

    Aleksandr S. Voronov

    2016-01-01

    Full Text Available This article describes the main characteristics of innovation clusters, analyzed the develop-ment plans of the cluster areas of growth on the basis of innovation in the various subjects of the federation, it proposed the principle of clustering of the «nuclear» type, dened by problems in the functioning of specialized distributed clusters on the basis of the organi-zational and marketing innovations, proposed scheme for sustainable innovation develop-ment of specialized distributed cluster.

  20. Assistance Focus: Asia/Pacific Region; Clean Energy Solutions Center (CESC)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-05-11

    The Clean Energy Solutions Center Ask an Expert service connects governments seeking policy information and advice with one of more than 30 global policy experts who can provide reliable and unbiased quick-response advice and information. The service is available at no cost to government agency representatives from any country and the technical institutes assisting them. This publication presents summaries of assistance provided to governments in the Asia/Pacific region, including the benefits of that assistance.

  1. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Minor business creation base type. Development of high pressure fluid aided dyeing and finishing system for cellulose textile products generating no waste liquid; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Cellulose kei sen'i seihin no koatsu ryutai ni yoru muhaieki senshoku kako system no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    There is a voice in the textile dyeing industry for a dyeing and finishing method without discharge of waste liquid from the viewpoint of environmental protection. When the special coexistence effect is applied to the technology of making polar dyes soluble in high pressure carbon dioxide, according to Associate Professor Mishima of Fukuoka University, a dyeing method is feasible wherein the separation of supercritical carbon dioxide and the dye is easier than in the conventional method of dyeing in water and wherein discharge of waste liquid after dyeing is not necessary. He also writes that technologies for recovering carbon dioxide have already been established. Under this project, attention is paid to cellulose textile products which will find a great demand, and efforts are made to commercialize a novel dyeing and finishing system of the low environmental impact type. The results of the research conducted under the project involve (1) the improvement of various dyes and assistants in their degree of solution in high pressure carbon dioxide, (2) development of a technology of attaching dyes and finishing agents to textiles, (3) designing and construction of a practical high pressure fluid dyeing and finishing apparatus, (4) search for optimum dyeing conditions for textile products using the said apparatus, and (5) the reinforced functions that textile products have after being dyed. (NEDO)

  2. 25 CFR 26.34 - What type of job training assistance may be approved?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What type of job training assistance may be approved? 26.34 Section 26.34 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES JOB PLACEMENT AND TRAINING PROGRAM Training Services § 26.34 What type of job training assistance may be...

  3. 25 CFR 26.11 - What type of Job Placement and Training assistance may be approved?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What type of Job Placement and Training assistance may be... JOB PLACEMENT AND TRAINING PROGRAM General Applicability § 26.11 What type of Job Placement and... supplemental assistance that supports job placement or training activities (see subpart B of this part for Job...

  4. Regional variation in the practice of euthanasia and physician-assisted suicide in the Netherlands.

    Science.gov (United States)

    Koopman, J J E; Putter, H

    2016-11-01

    The practice of euthanasia and physicianassisted suicide has been compared between countries, but it has not been compared between regions within the Netherlands. This study assesses differences in the frequencies, characteristics, and trends of euthanasia and physician-assisted suicide between five regions in the Netherlands and tries to explain the differences by demographic, socioeconomic, and health-related differences between these regions. Data on the frequencies, characteristics, and trends of euthanasia and physician-assisted suicide for each region and each year from 2002 through 2014 were derived from the annual reports of the Regional Review Committees. Averages and trends were determined using a regression model with the regions and years as independent variables. Demographic, socioeconomic, and health-related variables for each region and each year were derived from the Central Bureau for Statistics and added to the model as covariates. The frequencies, characteristics, and trends of euthanasia and physician-assisted suicide differed between the regions, whereas the frequencies of non-assisted suicide did not differ. Euthanasia and physician-assisted suicide were most frequent and were performed most often by general practitioners, in patients with cancer, in the patient's home, in North Holland. The regional differences remained after adjustment for demographic, socioeconomic, and health-related differences between the regions. More detailed research is needed to specify how and why the practice of euthanasia and physicianassisted suicide differs between regions in the Netherlands and to what extent these differences reflect a deficiency in the quality of care, such as other forms of regional variation in health care practice.

  5. Rethinking International Counterterrorism Assistance to the Greater Horn of Africa: Toward a Regional Risk Reduction Strategy

    Directory of Open Access Journals (Sweden)

    Matthew Schwartz

    2013-12-01

    Full Text Available The Horn of Africa has long been a recipient of foreign security assistance, with significant funds increasingly devoted to supporting subregional civilian-oriented counterterrorism efforts over the past decade. Despite efforts to better coordinate delivery, counterterrorism programming in the subregion generally remains fragmented, short-term, and siloed in implementation. This article argues that it is time to rethink the international community’s approach to counterterrorism assistance to the Horn of Africa and calls for a cohesive regional approach that not only bridges the gap between security and development, but also the gap between counterterrorism and human security. It emphasizes that the international community must not only better coordinate existing streams of counterterrorism assistance to the region, but also rethink how this assistance is designed and the ways it can be delivered to complement broader subregional development and security agendas. After a brief introduction to international counterterrorism assistance to the Horn of Africa, the article examines linkages across three thematic streams of programming being delivered to the subregion: anti-money laundering and countering the financing of terrorism; criminal justice capacity building assistance to counter terrorism; and, countering violent extremism. This discussion will highlight the need for a regional risk reduction strategy for the Horn of Africa that not only builds on the interplay of different streams of counterterrorism assistance, but on synergies across broader subregional development and security agendas as well.

  6. Collision assisted Zeeman cooling with multiple types of atoms

    Science.gov (United States)

    Hamilton, Mathew S.; Wilson, Rebekah F.; Roberts, Jacob L.

    2014-01-01

    Through a combination of spin-exchange collisions in a magnetic field and optical pumping, it is possible to cool a gas of atoms without requiring the loss of atoms from the gas. This technique, collision assisted Zeeman cooling (CAZ), was developed theoretically assuming a single atomic species [G. Ferrari, Eur. Phys. J. D 13, 67 (2001)]. We have extended this cooling technique to a system of two atomic species rather than just one and have developed a simple analytic model describing the cooling rate. We find that the two-isotope CAZ cooling scheme has a clear theoretical advantage in systems that are reabsorption limited.

  7. [Effects of road construction on regional vegetation types].

    Science.gov (United States)

    Liu, Shi-Liang; Liu, Qi; Wang, Cong; Yang, Jue-Jie; Deng, Li

    2013-05-01

    As a regional artificial disturbance component, road exerts great effects on vegetation types, and plays a substantial role in defining vegetation distribution to a certain extent. Aiming at the tropical rainforest degradation and artificial forest expansion in Yunnan Province of Southwest China, this paper analyzed the effects of road network extension on regional vegetation types. In the Province, different classes of roads had different effects on the vegetation types, but no obvious regularity was observed in the effects on the patch areas of different vegetation types due to the great variations of road length and affected distance. However, the vegetation patch number was more affected by lower class roads because of their wide distribution. As for different vegetation types, the vegetations on cultivated land were most affected by roads, followed by Castanopsis hystrix and Schima wallichii forests. Road network formation contributed most to the vegetation fragmentation, and there existed significant correlations between the human disturbance factors including village- and road distributions.

  8. THE DETONATION MECHANISM OF THE PULSATIONALLY ASSISTED GRAVITATIONALLY CONFINED DETONATION MODEL OF Type Ia SUPERNOVAE

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, G. C. IV; Graziani, C.; Weide, K.; Norris, J.; Hudson, R.; Lamb, D. Q. [Flash Center for Computational Science, University of Chicago, Chicago, IL 60637 (United States); Fisher, R. T. [Department of Physics, University of Massachusetts Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02740 (United States); Townsley, D. M. [Department of Physics and Astronomy, University of Alabama, Tuscaloosa, AL 35487 (United States); Meakin, C. [Steward Observatory, University of Arizona, Tucson, AZ 85721 (United States); Reid, L. B. [NTEC Environmental Technology, Subiaco WA 6008 (Australia)

    2012-11-01

    We describe the detonation mechanism composing the 'pulsationally assisted' gravitationally confined detonation (GCD) model of Type Ia supernovae. This model is analogous to the previous GCD model reported in Jordan et al.; however, the chosen initial conditions produce a substantively different detonation mechanism, resulting from a larger energy release during the deflagration phase. The resulting final kinetic energy and {sup 56}Ni yields conform better to observational values than is the case for the 'classical' GCD models. In the present class of models, the ignition of a deflagration phase leads to a rising, burning plume of ash. The ash breaks out of the surface of the white dwarf, flows laterally around the star, and converges on the collision region at the antipodal point from where it broke out. The amount of energy released during the deflagration phase is enough to cause the star to rapidly expand, so that when the ash reaches the antipodal point, the surface density is too low to initiate a detonation. Instead, as the ash flows into the collision region (while mixing with surface fuel), the star reaches its maximally expanded state and then contracts. The stellar contraction acts to increase the density of the star, including the density in the collision region. This both raises the temperature and density of the fuel-ash mixture in the collision region and ultimately leads to thermodynamic conditions that are necessary for the Zel'dovich gradient mechanism to produce a detonation. We demonstrate feasibility of this scenario with three three-dimensional (3D), full star simulations of this model using the FLASH code. We characterized the simulations by the energy released during the deflagration phase, which ranged from 38% to 78% of the white dwarf's binding energy. We show that the necessary conditions for detonation are achieved in all three of the models.

  9. Reflex sympathetic dystrophy/complex regional pain syndrome, type 1

    African Journals Online (AJOL)

    Enrique

    with MRI every 3 months and the bone marrow oedema disappeared after 6 months. Introduction ... SA JOURNAL OF RADIOLOGY • August 2004. Reflex sympathetic dystrophy/complex regional pain syndrome, type 1 ... may be either trauma of external origin or iatrogenic, post surgery. In some patients particularly children ...

  10. Geographic Region, Size, and Program Type in Family Practice Residencies.

    Science.gov (United States)

    Berg, Jolene K.; Garrard, Judith

    1981-01-01

    Research on residency education in family practice is discussed. Programmatic variables are examined: geographic region, size, and type of program. Definitions of these variables are provided, the current distribution of family practice residency programs across each of these variables is described, and data for use by other researchers is…

  11. [Complex regional pain syndrome type 1: negating the myth

    NARCIS (Netherlands)

    Frolke, J.P.M.; Dongen, R.T.M. van; Meent, H. van de

    2015-01-01

    Complex regional pain syndrome type 1 (CRPS-1) was identified in the Netherlands more than 30 years ago, but since then the arguments supporting this diagnosis have become weaker. Incidence has decreased, it is often not possible to make a definite diagnosis, the pathophysiology remains unclear and

  12. Evidence based guidelines for complex regional pain syndrome type 1

    NARCIS (Netherlands)

    Perez, R.S.G.M.; Zollinger, P.E.; Dijkstra, P.U.; Thomassen-Hilgersom, I.L.; Zuurmond, W.W.A.; Rosenbrand, C.J.G.M.; Geerzen, J.H.B.

    2010-01-01

    Background: Treatment of complex regional pain syndrome type I (CRPS-I) is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I.Method: A multidisciplinary task force graded literature evaluating treatment effects for CRPS-I according

  13. Evidence based guidelines for complex regional pain syndrome type 1

    NARCIS (Netherlands)

    Perez, Roberto S.; Zollinger, Paul E.; Dijkstra, Pieter U.; Thomassen-Hilgersom, Ilona L.; Zuurmond, Wouter W.; Rosenbrand, Kitty C. J.; Geertzen, Jan H.

    2010-01-01

    Background: Treatment of complex regional pain syndrome type I (CRPS-I) is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I. Method: A multidisciplinary task force graded literature evaluating treatment effects for CRPS-I according

  14. Decadal changes of weather types in the alpine region

    Energy Technology Data Exchange (ETDEWEB)

    Stefanicki, G.; Talkner, P.; Weber, R.O. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1997-06-01

    The annual occurrence of different weather types of Schuepp`s synoptic classification in the Alpine region has changed since the beginning of its recording 1945. The annual frequency (number of days) of convective types has increased and that of advective types has decreased. In parallel the number of long-lasting convective episodes rose and the number of long-lasting advective episodes lessened. Most of the change took place in winter. The frequencies of different weather types and the annual mean of certain meteorological parameters are significantly correlated. Moreover, there is a strong interdependence between the subclass of high pressure types and the North Atlantic Oscillation (NAO) index. (author) 3 figs., 3 refs.

  15. Relation between extinction and assisted colonization of plants in the arctic-alpine and boreal regions.

    Science.gov (United States)

    Pykälä, Juha

    2017-06-01

    Assisted colonization of vascular plants is considered by many ecologists an important tool to preserve biodiversity threatened by climate change. I argue that assisted colonization may have negative consequences in arctic-alpine and boreal regions. The observed slow movement of plants toward the north has been an argument for assisted colonization. However, these range shifts may be slow because for many plants microclimatic warming (ignored by advocates of assisted colonization) has been smaller than macroclimatic warming. Arctic-alpine and boreal plants may have limited possibilities to disperse farther north or to higher elevations. I suggest that arctic-alpine species are more likely to be driven to extinction because of competitive exclusion by southern species than by increasing temperatures. If so, the future existence of arctic-alpine and boreal flora may depend on delaying or preventing the migration of plants toward the north to allow northern species to evolve to survive in a warmer climate. In the arctic-alpine region, preventing the dispersal of trees and shrubs may be the most important method to mitigate the negative effects of climate change. The purported conservation benefits of assisted colonization should not be used to promote the migration of invasive species by forestry. © 2016 Society for Conservation Biology.

  16. Source-Type Identification Analysis Using Regional Seismic Moment Tensors

    Science.gov (United States)

    Chiang, A.; Dreger, D. S.; Ford, S. R.; Walter, W. R.

    2012-12-01

    Waveform inversion to determine the seismic moment tensor is a standard approach in determining the source mechanism of natural and manmade seismicity, and may be used to identify, or discriminate different types of seismic sources. The successful applications of the regional moment tensor method at the Nevada Test Site (NTS) and the 2006 and 2009 North Korean nuclear tests (Ford et al., 2009a, 2009b, 2010) show that the method is robust and capable for source-type discrimination at regional distances. The well-separated populations of explosions, earthquakes and collapses on a Hudson et al., (1989) source-type diagram enables source-type discrimination; however the question remains whether or not the separation of events is universal in other regions, where we have limited station coverage and knowledge of Earth structure. Ford et al., (2012) have shown that combining regional waveform data and P-wave first motions removes the CLVD-isotropic tradeoff and uniquely discriminating the 2009 North Korean test as an explosion. Therefore, including additional constraints from regional and teleseismic P-wave first motions enables source-type discrimination at regions with limited station coverage. We present moment tensor analysis of earthquakes and explosions (M6) from Lop Nor and Semipalatinsk test sites for station paths crossing Kazakhstan and Western China. We also present analyses of smaller events from industrial sites. In these sparse coverage situations we combine regional long-period waveforms, and high-frequency P-wave polarity from the same stations, as well as from teleseismic arrays to constrain the source type. Discrimination capability with respect to velocity model and station coverage is examined, and additionally we investigate the velocity model dependence of vanishing free-surface traction effects on seismic moment tensor inversion of shallow sources and recovery of explosive scalar moment. Our synthetic data tests indicate that biases in scalar

  17. Assistive Solutions in Practice: Experiences from AAL Pilot Regions in Austria.

    Science.gov (United States)

    Ates, Nesrin; Aumayr, Georg; Drobics, Mario; Förster, Kristina Maria; Frauenberger, Christopher; Garschall, Markus; Kofler, Manfred; Krainer, Daniela; Kropf, Johannes; Majcen, Kurt; Oberzaucher, Johannes; Piazolo, Felix; Rzepka, Angelika; Sauskojus, Julia; Schneider, Cornelia; Stainer-Hochgatterer, Andreas; Sturm, Nadine; Waibel, Uli; Willner, Viktoria

    2017-01-01

    Since 2012 six AAL pilot regions were launched in Austria. The main goal of these pilot regions is to evaluate the impact of AAL technologies in daily use considering the entire value chain. Additionally, go-to market strategies for assistive technologies based on an involvement of all relevant stakeholders are developed. Within this paper an overview of the specific objectives, approaches and the status of all Austrian AAL pilot regions is given. Taking into account the different experiences of the different pilot regions, specific challenges in establishing, implementing and sustaining pilot region projects are discussed and lessons-learned are presented. Results show that a careful planning of all project phases taking into account available resources is crucial for the successful implementation of an AAL pilot region. In particular, this applies to all activities related to the active involvement of end-users.

  18. Fiscal 1999 achievement report on the venture business assisting type regional consortium - Minor business creation base type. Development of simplified extraction/purification method for highly purified large-size plasmids; 1999 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Kanbenka kojundo ogata plasmid chushutsu seiseiho no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The project aims to develop biotechnological industries in Okinawa Prefecture by embodying a method for obtaining large-size plasmids in a short time at low cost without a special apparatus, for which efforts were made to develop and commercialize a kit comprising an eluate from plasmid cells and a set of columns and eluate for purification. Under this project, University of the Ryukyus well experienced in the handling of plasmid DNAs and Advanced Medical Biological Science Institute jointly developed a 'simplified extraction/purification method for highly purified large-size plasmids.' The developed techniques or methods are described below. A concentration method was developed not using centrifugal operation for escherichia coli cultured in a closed mass culture device. A buffer exchange method in a closed system was developed, continuous from escherichia coli concentration to elution. A column assisted DNA purification method consuming but a short time was established. With these combined, the development is now complete of the technology and device for plasmid DNA elution from escherichia coli by an uninterrupted operation in a completely closed system. (NEDO)

  19. Fiscal 1999 achievement report on the venture business assisting type regional consortium - Minor business creation base type. Development of simplified extraction/purification method for highly purified large-size plasmids; 1999 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Kanbenka kojundo ogata plasmid chushutsu seiseiho no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The project aims to develop biotechnological industries in Okinawa Prefecture by embodying a method for obtaining large-size plasmids in a short time at low cost without a special apparatus, for which efforts were made to develop and commercialize a kit comprising an eluate from plasmid cells and a set of columns and eluate for purification. Under this project, University of the Ryukyus well experienced in the handling of plasmid DNAs and Advanced Medical Biological Science Institute jointly developed a 'simplified extraction/purification method for highly purified large-size plasmids.' The developed techniques or methods are described below. A concentration method was developed not using centrifugal operation for escherichia coli cultured in a closed mass culture device. A buffer exchange method in a closed system was developed, continuous from escherichia coli concentration to elution. A column assisted DNA purification method consuming but a short time was established. With these combined, the development is now complete of the technology and device for plasmid DNA elution from escherichia coli by an uninterrupted operation in a completely closed system. (NEDO)

  20. Effectiveness of a regional prepregnancy care program in women with type 1 and type 2 diabetes

    DEFF Research Database (Denmark)

    Murphy, Helen R.; Roland, Jonathan M.; Skinner, Timothy C.

    2010-01-01

    of 680 pregnancies in women with type 1 and type 2 diabetes was performed. Primary outcomes were adverse pregnancy outcome (congenital malformation, stillbirth, or neonatal death), congenital malformation, and indicators of pregnancy preparation (5 mg folic acid, gestational age, and A1C). Comparisons...... with improved pregnancy preparation and reduced risk of adverse pregnancy outcome in type 1 and type 2 diabetes. Prepregnancy care had benefits beyond improved glycemic control and was a stronger predictor of pregnancy outcome than maternal obesity, ethnicity, or social disadvantage.......OBJECTIVE - To implement and evaluate a regional prepregnancy care program in women with type 1 and type 2 diabetes. RESEARCH DESIGN AND METHODS - Prepregnancy care was promoted among patients and health professionals and delivered across 10 regional maternity units. A prospective cohort study...

  1. Fiscal 2000 achievement report. Venture business assisting type regional consortium - Minor business creation base type (Development of aluminum alloy casting system using aluminum titanate ceramic member); 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Chitansan aluminium ceramics buzai wo shiyoshita aluminium gokin chuzo system no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    An automatic liquid metal charging system driven by a linear induction type electromagnetic pump is developed, with its members to be in contact with liquid aluminum alloy being constituted of aluminum titanate ceramics not to be wetted by liquid aluminum alloy and highly resistant to thermal impact. Technologies for casting aluminum titanate ceramic members in plaster molds, CIP (cold isostatic pressing) molding, and burning were established. The mechanism of wettability of liquid aluminum alloy on aluminum titanate ceramic members was elucidated, and an aluminum titanate ceramic member with a dense spinel layer formed thereon in situ was developed for improvement on non-wettability. The developed member remained non-wettable more than six times longer than conventional members. A special electronic counter mechanism was developed by installing in a conduit an aluminum titanate ceramic made impeller whose revolution was converted into electric signals for the measurement of the amount of charged liquid. A non-asbestos polycrystalline alumina-silica fiber was selected as the insulator for the melting/holding furnace, which enabled 30% energy conservation as compared with the conventional type. (NEDO)

  2. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Core industry creation type. Comprehensive research and development for reducing ABS (MABS) sensor system into small module for enhancing vehicle steering safety; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Koji no sharyo soansei wo jitsugensuru ABS (MABS) sensor system no kogata module ka ni tsuite no sogo kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The effort aims to develop a sensor system to enable overall VDC (vehicle dynamic control). The goal is to manufacture a small module type sensor system more than 20 times higher than the conventional type in responding speed and accuracy, which will use a novel ABS (anti-lock braking system) capable of direct and real-time measurement of axial forces in the four directions. The prototype module will be a package in which a system-on-a-chip accommodating peripheral circuits is integrated with a sensor. In the effort to develop a novel multi-axial sensing system (MASS) for a smaller ABS, a circuit optimization technology was developed. A dedicated IC (integrated circuit) was developed for a system to process a large volume of signals. In the effort to develop technologies for packaging the novel sensor system and for constructing modules, technologies were developed for integrating sensor components and an IC into one, module junctioning, module installation, simplification of the installation process, and for the manufacturing of modules. Developed in the effort to optimize MASS were technologies involving the selection and evaluation of sensor components and the enhancement of such processes, optimization of the sensor itself, and the improvement of the sensor system for higher efficiency in calculation. Sensor modules were tested aboard vehicles and the compatibility of the system-on-a-chip with the MASS module was confirmed. (NEDO)

  3. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Minor business creation base type. Development of 1-chip multifunctional motion sensor and its application to intelligent module; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. 1 chip gata takino undo sensor no kaihatsu to intelligent module eno tekiyo

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The aim is to embody an intelligent micromodule for sensing bodily motions. For this purpose, technologies were established for high accuracy/high aspect ratio etching of crystals and for detecting angular velocity and acceleration, and a 1-chip multifunctional motion sensor was developed. The results of the efforts are briefly described below. A 1-chip multifunctional motion sensor (device size: 16 times 6 times 0.3mm) was developed, capable of simultaneously detecting uniaxial acceleration and uniaxial angular velocity, and an operating circuit was established for the detection. Using the 1-chip multifunctional motion sensor, a wrist watch type intelligent module was developed, capable of discriminating between various patterns of human behavior (walking, jogging, desk work, etc.). An intelligent module and the host computer were connected by wire or radio enabling the real-time observation of a patient's kinetic behavior, and this helped develop an application program allowing the quantification of the rate of recovery of patients undergoing rehabilitation. Using an intelligent module, an application program was developed enabling a laryngeal patient to establish communication by a physical action in case of emergency. (NEDO)

  4. Fiscal 1999 achievement report on the venture business assisting type regional consortium - Minor business creation base type. Development of environmental protection oriented technology for effectively utilizing waste paper; 1999 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Kankyo hozengata no koshi no yuko riyo gijutsu no kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The effort aims to use low grade waste paper out of various grades of waste paper, whose recovery does not make good progress, as a raw material for the development of value-added, commercially competitive products and to contribute to the enhancement of waste paper recovery. A dry pulverization method less polluting the environment and not requiring a drying process is established, and types of waste paper and optimum conditions for their pulverization are made clear. A molding system using a steam injection method capable of atmospheric pressure control is established, and this enables the molding of pulverized waste paper not only into flat boards but also into corrugated boards. It is found that water contained in the waste paper alone produces a result similar to that expected from steam injection. A partitioning board is produced from waste paper, and it is found to be near the conventional product in terms of noise absorption. Old newspaper and corrugated cardboard are pulverized and an air filter is developed, which is similar to the conventional product in terms of operating efficiency and life. Waste paper is carbonized, and then charcoal with more pores than the conventional charcoal is produced. The porous charcoal is found to be usable in vegetable beds. (NEDO)

  5. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Core industry creation type. Research and development of polisher robot system using intelligent force control; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Intelligent ryoku seigyo wo mochiita kenma robot system no kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    The effort aims to automatize the manufacture of wooden furniture by robotizing the polishing work in the field of wooden furniture manufacturing, making use of the seeds provided by intelligent force control technologies. The intelligent force control technologies ('Delicate control of force for the open architecture type industrial robot' and 'Method for target orbit generation not requiring joystick teaching') of Saga University and the interior laboratory of Fukuoka Prefectural Industrial Research Institute are evolved and applied, and are integrated with the 3-dimensional object modelling technology developed by the mechanical and electronic laboratory, Fukuoka Prefectural Industrial Research Institute, and the CAD (computer aided design) data conversion technology developed by ASA Systems Inc. The result was a polisher robot system experimentally fabricated to satisfy the need of an automated polishing process in the wooden furniture manufacturing industry. The robot was tested, and achieved a surface coarseness level of 5{mu}m or less. As for the manufacturing rate, it attained a rate of approximately 100mm/s which was two times higher than the rate to be expected from a skilled worker. (NEDO)

  6. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Core industry creation type. Research and development of high-accuracy fabrication technology of aspheric optical component creation technology using parallel grinding method; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Parallel kensaku hoshiki ni yoru koseido hikyumen kogaku soshi sosei gijutsu no kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Research and development was carried out for the establishment and commercialization of the technical seeds of a newly proposed 'parallel grinding type aspheric surface grinding method,' based on the results of studies of ultra-accuracy grinding and aspheric surface machining technologies conducted at Tohoku University. The new method is characterized in that a work point on the work piece faces the grinding point on the grindstone cross section on the one-to-one basis because the grinding point travels on the grindstone cross section. Accordingly, the method is quite suitable for corrective grinding for eliminating only the error in case a geometrical error occurs on the wrought surface. For this purpose, measurement of the machine surface on board the machine is indispensable. Hence: a study of corrective grinding methods under an on-board measuring system. As the result, the initially intended geometrical accuracy level was attained in the machining of axis-symmetric aspheric glass lenses and aspheric metal molds, and coarseness on the finished surface in the grinding of glass lenses was reduced to 0.3{mu}m using a diamond grindstone. In conclusion, machining accuracy and finished surface coarseness were remarkably improved, and this enables machining without the need of polishing and demonstrates that there are possibilities of commercialization. (NEDO)

  7. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Minor business creation base type. Commercialization of human monoclonal antibody as investigational reagent; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Hitogata monoclonal kotai no kenkyuyo shiyaku to shite no seihinka

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Technical seeds of in vitro immunization technologies for human peripheral lymphocytes and technologies for human cell fusion, both developed by Kita-Kyushu National College of Technology, are used, and human monoclonal antibodies are prepared easy to connect to tumor markers, allergens, and microbes. The project aims further to develop a technology for small-scale high-density production of such antibodies and to supply them as human monoclonal antibody reagents meeting the needs of bio-researchers in the fields of medicine, pharmacy, biology, agriculture, or the like. A human fusion partner cell strain SK-729-1 clone is obtained, which is high in ability to produce antibodies. Since the obtained cell is culturable in a serumless medium, a fusion cell strain prepared using the said cell strain is also culturable in a serumless medium. Hence: advanced refining now available for human monoclonal antibodies. Nine types of antibodies are acquired. Furthermore, it is made possible to predict the antibody reaction and the antibody amount in a simplified way. Containers for antibody preservation are screened, and a container is selected in a freezing/thawing test, capable of preserving 90% or more of antibodies. A high-density culture that uses the hollow fiber cartridge is now feasible. (NEDO)

  8. Mathematical models and methods of assisting state subsidy distribution at the regional level

    Science.gov (United States)

    Bondarenko, Yu V.; Azarnova, T. V.; Kashirina, I. L.; Goroshko, I. V.

    2018-03-01

    One of the most common forms of state support in the world is subsidization. By providing direct financial support to businesses, local authorities get an opportunity to set certain performance targets. Successful achievement of such targets depends not only on the amount of the budgetary allocations, but also on the distribution mechanisms adopted by the regional authorities. Analysis of the existing mechanisms of subsidies distribution in Russian regions shows that in most cases the choice of subsidy calculation formula and its parameters depends on the experts’ subjective opinion. The authors offer a new approach to assisting subsidy distribution at the regional level, which is based on mathematical models and methods, allowing to evaluate the influence of subsidy distribution on the region’s social and economic development. The results of calculations were discussed with the regional administration representatives who confirmed their significance for decision-making in the sphere of state control.

  9. Analysis of Contemporary Methods for Designing Rotary Type Ventricular Assist Devices

    Directory of Open Access Journals (Sweden)

    E. P. Banin

    2015-01-01

    Full Text Available The research object is inlet apparatus of ventricular assist device, namely inlet cannula and straightener.The purpose of the study is to reveal features of blood flow in inlet apparatus of ventricular assist device. The mathematical modeling is carried out by computational fluid dynamics analysis in a stationary setting.The first part of study concerns the analysis of existing approaches to the numerical and experimental studies in designing the ventricular assist devices of rotary type. It reveals the features of each approach for their further application in practice. The article presents an original design of developed hydraulic test bench to verify the results of mathematical modeling. Analysis of foreign authors’ studies showed that there is no enough attention paid to design of the adjacent pump assemblies of ventricular assist device. The second part of study considers direct mathematical modeling of input apparatus of ventricular assist device. The study examined straightener with three or four blades. Mathematical modeling has revealed the presence of potentially dangerous stagnation zones and essential asymmetry of the outlet flow from the input unit. The found features must be taken in consideration in designing the ventricular assist device pumps. In the future we plan to use obtained data to create a parametric model of the rotor and the diffuser considering the abovementioned features.

  10. Alveolar ridge expansion-assisted orthodontic space closure in the mandibular posterior region.

    Science.gov (United States)

    Ozer, Mete; Akdeniz, Berat Serdar; Sumer, Mahmut

    2013-12-01

    Orthodontic closure of old, edentulous spaces in the mandibular posterior region is a major challenge. In this report, we describe a method of orthodontic closure of edentulous spaces in the mandibular posterior region accelerated by piezoelectric decortication and alveolar ridge expansion. Combined piezosurgical and orthodontic treatments were used to close 14- and 15-mm-wide spaces in the mandibular left and right posterior areas, respectively, of a female patient, aged 18 years and 9 months, diagnosed with skeletal Class III malocclusion, hypodontia, and polydiastemas. After the piezoelectric decortication, segmental and full-arch mechanics were applied in the orthodontic phase. Despite some extent of root resorption and anchorage loss, the edentulous spaces were closed, and adequate function and esthetics were regained without further restorative treatment. Alveolar ridge expansion-assisted orthodontic space closure seems to be an effective and relatively less-invasive treatment alternative for edentulous spaces in the mandibular posterior region.

  11. Superluminal propagation in a poly-chromatically driven gain assisted four-level N-type atomic system

    International Nuclear Information System (INIS)

    Bacha, Bakht Amin; Ahmad, Iftikhar; Ullah, Arif; Ali, Hazrat

    2013-01-01

    We investigate the behavior of light propagation in an N-type four-level gain assisted model (Agarwal and Dasgupta 2004 Phys. Rev. A 70 023802) under poly-chromatic pump fields. The system exhibits interesting results of multiple controllable pairs of the gain doublet profile with changes in the intensity of the control field. We observe multiple anomalous dispersive regions for superluminal propagation in the medium. A negative group velocity of −37.50 m s −1 with a negative time delay of −8 ms is observed between each gain doublet in anomalous dispersive regions. This generalized model and its predictions can be tested with existing experimental setups. (paper)

  12. Laparoscopy-Assisted Billroth I Gastrectomy for Ectopic Pancreas in the Prepyloric Region

    Directory of Open Access Journals (Sweden)

    Yueh-Tsung Lee

    2012-11-01

    Full Text Available Ectopic pancreatic tissue is an uncommon developmental anomaly. The condition mostly occurs in the gastrointestinal tract and is usually asymptomatic. It rarely causes symptoms of inflammation, bleeding and perforation, and has potential for malignant change. Though it is an uncommon condition, cases of ectopic pancreas have been reported worldwide. Preoperative diagnosis of ectopic pancreas is challenging because of its nonspecific symptoms and signs. Owing to the revolution of minimally invasive surgery, submucosal tumors of the stomach can be resected by laparoscopic techniques. We have earlier reported on a case of ectopic pancreas in the stomach treated by robotics-assisted laparoscopic wedge resection. Herein, we report a case of ectopic pancreas in the prepyloric region of the stomach. A 44-year-old female presented with a two-week history of epigastralgia with radiation to the back. She received endoscopy check-up which disclosed a mass in the stomach. By endoscopic findings, a submucosal lesion in the prepyloric region with umbilical folding on the mucosa was identified. The umbilical folding on the mucosa hint the orifice of the duct of ectopic pancreas into the gastric mucosa suggestive of ectopic pancreas. Contrast-enhanced abdominal computed tomography showed a 5 cm cystic mass with heterogeneous content. To sum it up, the patient was diagnosed as ectopic pancreas in the stomach. She underwent laparoscopy-assisted antrectomy with Billroth I anastomosis (excision of the antrum and prepyloric region with reconstruction of gastrointestinal continuity by gastroduodenostomy and had an uneventful hospitalization course. The histopathology of the resected tumor demonstrated ectopic pancreatic tissue in the gastric wall. To the best of our knowledge, excision of gastric ectopic pancreas using laparoscopy-assisted antrectomy with Billroth I anastomosis has never been reported in the literature.

  13. Ventilation-perfusion scans in neonatal regional pulmonary emphysema complicating ventilatory assistance

    International Nuclear Information System (INIS)

    Leonidas, J.C.; Moylan, F.M.B.; Kahn, P.C.; Ramenofsky, M.L.

    1978-01-01

    Two cases of ventilator-related neonatal lobar overexpansion with similar radiographic appearance, but probably different pathogenesis, are presented. In one infant, persistent interstitial lobar emphysema was confirmed by markedly decreased perfusion shown on scintigraphy; this information was of great value in predicting the beneficial effect of lobectomy. In the other case, ventilation and perfusion scans indicated functional value of the emphysematous lobe and correctly suggested conservative management. Radioisotope lung scans may provide valuable information regarding lung function in regional pulmonary emphysema associated with assisted ventilation in neonatal respiratory distress syndrome, and thus determine patient management

  14. Complex regional pain syndrome type I following pacemaker implantation

    Directory of Open Access Journals (Sweden)

    Sangita Kamath

    2015-12-01

    Full Text Available A 70-year-old woman presented with burning pain and swelling over dorsum of right hand and small joints of the fingers, associated with redness, feeling of warmth, and stiffness of the fingers, with inability to bend the fingers since 2 months. The symptoms were progressively increasing in intensity for the past 1 month. There was no history of fever or trauma to the hand. Two months before her symptoms started, she had permanent pacemaker implanted for complete heart block with syncope. She was hypertensive and was on regular medication. Her X-ray of right hand showed decreased bone density (demineralisation, suggestive of osteopenia. A diagnosis of reflex sympathetic dystrophy syndrome or complex regional pain syndrome type I induced by pacemaker insertion was made. She was treated with amitriptyline and steroids, after which her symptoms improved dramatically.

  15. Evidence based guidelines for complex regional pain syndrome type 1

    Directory of Open Access Journals (Sweden)

    Thomassen-Hilgersom Ilona L

    2010-03-01

    Full Text Available Abstract Background Treatment of complex regional pain syndrome type I (CRPS-I is subject to discussion. The purpose of this study was to develop multidisciplinary guidelines for treatment of CRPS-I. Method A multidisciplinary task force graded literature evaluating treatment effects for CRPS-I according to their strength of evidence, published between 1980 to June 2005. Treatment recommendations based on the literature findings were formulated and formally approved by all Dutch professional associations involved in CRPS-I treatment. Results For pain treatment, the WHO analgesic ladder is advised with the exception of strong opioids. For neuropathic pain, anticonvulsants and tricyclic antidepressants may be considered. For inflammatory symptoms, free-radical scavengers (dimethylsulphoxide or acetylcysteine are advised. To promote peripheral blood flow, vasodilatory medication may be considered. Percutaneous sympathetic blockades may be used to increase blood flow in case vasodilatory medication has insufficient effect. To decrease functional limitations, standardised physiotherapy and occupational therapy are advised. To prevent the occurrence of CRPS-I after wrist fractures, vitamin C is recommended. Adequate perioperative analgesia, limitation of operating time, limited use of tourniquet, and use of regional anaesthetic techniques are recommended for secondary prevention of CRPS-I. Conclusions Based on the literature identified and the extent of evidence found for therapeutic interventions for CRPS-I, we conclude that further research is needed into each of the therapeutic modalities discussed in the guidelines.

  16. Environment-assisted Quantum Critical Effect for Excitation Energy Transfer in a LH2-type Trimer

    Science.gov (United States)

    Xu, Lan; Xu, Bo

    2015-10-01

    In this article, we are investigating excitation energy transfer (EET) in a basic unit cell of light-harvesting complex II (LH2), named a LH2-type trimer. Calculation of energy transfer efficiency (ETE) in the framework of non-Markovian environment is also implemented. With these achievements, we theoretically predict the environment-assisted quantum critical effect, where ETE exhibits a sudden change at the critical point of quantum phase transition (QPT) for the LH2-type trimer. It is found that highly efficient EET with nearly unit efficiency may occur in the vicinity of the critical point of QPT.

  17. Complex regional pain syndromes (CRPS type 1 validating case histories

    Directory of Open Access Journals (Sweden)

    P. Berger

    2003-01-01

    Full Text Available The treatment of patients with complex regional pain syndrome (CRPS type 1 is challenging and unpredictable as the condition presents with vascular and neuropathic symptoms after nil or even minor injury to a peripheral nerve. The condition is one of a pain and motor dysfunction. The pathophysiology is not well understood and the relief of symptoms may change from being sympathetically mediated to sympathetically independent during  the course of the disease. At any stage physiotherapy has been advocated as the corner stone and most important aspect of treatment in the rehabilitation of these individuals but unfortunately it has been difficult to execute when pain is exacerbated due to allodynia (unbearable to touch or move and hyperalgesia. Best results have been obtained if the patients are recognised and treated in the early or acute phase and it has been found that through careful assessment and analysis these patients can be recognised by previous events that have occurred in their initial case history. The treatment in the acute stage with physiotherapy modalities such as electrical stimulation and acupuncture will produce an early cessation of the symptoms and prevention of the disease developing into the fully blown CRPS type 1 with irreversible and possibly atrophic consequences. Case histories have been presented that illustrate these important aspects and demonstrate  the value of early and the appropriate physiotherapy that may be more successful than other pharmacological and physical interventions in this disease.

  18. Reflex sympathetic dystrophy/complex regional pain syndrome, type 1

    Directory of Open Access Journals (Sweden)

    S.H. Botha

    2004-06-01

    Full Text Available Complex regional pain syndrome (CPRS, type 1 is a pain disorder that develops unpredictably and can follow a minor injury. A 12-year-old boy presented with severe pain in the feet and could not walk or stand weight bearing. Normal X-rays showed osteopenic changes and radiolucent lines, which appeared to be stress fractures. Three-phase bone scintigraphy showed no uptake in the left lower leg on the blood pool phase or on the immediate or delayed images. This indicated typical CPRS type 1 in children. The uptake in the right foot was increased and the stress fracture and other illness could not be differentiated. Computed tomography was done to exclude stress fractures. Only osteopenic changes in both calcaneus bones were found and there was no evidence of cortical stress fractures. Magnetic resonance images revealed oedema in the calcaneus and talus bones of both feet. The patient received epidural narcotic infusion with sympathetic blockage for 1 week combined with extensive physiotherapy. The blood pool phase of the bone scan became normal within 2 weeks, and increased uptake in both feet was noticed. The patient was followed up with MRI every 3 months and the bone marrow oedema disappeared after 6 months.

  19. ACTIVITIES RESULTS AIMED AT IMPROVED MEDICAL ASSISTANCE TO THE VASCULAR PATIENTS IN TOMSK REGION

    Directory of Open Access Journals (Sweden)

    D. M. Plotnikov

    2013-01-01

    Full Text Available Acute disorders of cerebral circulation remain serious medical and social problem associated with high disability and mortality rates. Since 2011 Tomsk oblast is a participating member of the medical campaign aimed at improved medical services to the vascular patients. The preliminary implementation data analysis for 2012 revealed improvement of most of the indices of medical support to patients suffering from acute cerebral circulation; increased number of the in-patient cases (Regional Vascular Center and primary vascular department, decreased lethality rates from strokes, specifically hemorrhagic cases. Strict observance of the Regulations on Medical Assistance for stroke patients and the using of modern methods of therapy allowed to decrease hospital mortality in the Primary Vascular Departments and early mortality in the Regional Vascular Center. The active implementation of neurorehabilitation approaches resulted in the increased number of patients who do not require third parties’ assistance. Analysis of the work of the departments helped to identifying current problems and perspectives of further development of special medical care for stroke patients.

  20. Weather types and strokes in the Augsburg region (Southern Germany)

    Science.gov (United States)

    Beck, Christoph; Ertl, Michael; Giemsa, Esther; Jacobeit, Jucundus; Naumann, Markus; Seubert, Stefanie

    2017-04-01

    Strokes are one of the leading causes of morbidity and mortality worldwide and the main reason for longterm care dependency in Germany. Concerning the economical impact on patients and healthcare systems it is of particular importance to prevent this disease as well as to improve the outcome of the affected persons. Beside the primary well-known risk factors like hypertension, cigarette smoking, physical inactivity and others, also weather seems to have pronounced influence on the occurrence and frequency of strokes. Previous studies most often focused on effects of singular meteorological variables like ambient air temperature, air pressure or humidity. An advanced approach is to link the entire suite of daily weather elements classified to air mass- or weather types to cerebrovascular morbidity or mortality. In a joint pilot study bringing together climatologists, environmental scientists and physicians from the University of Augsburg and the clinical centre Augsburg, we analysed relationships between singular meteorological parameters as well as combined weather effects (e.g. weather types) and strokes in the urban area of Augsburg and the surrounding rural region. A total of 17.501 stroke admissions to Neurological Clinic and Clinical Neurophysiology at Klinikum Augsburg between 2006 and 2015 are classified to either "ischaemic" (16.354) or "haemorrhagic" (1.147) subtype according to etiology (based on the International Classification of Diseases - 10th Revision). Spearman correlations between daily frequencies of ischaemic and haemorrhagic strokes and singular atmospheric parameters (T, Tmin, Tmax, air pressure, humidity etc.) measured at the DWD (German weather service) meteorological station at Augsburg Muehlhausen are rather low. However, higher correlations are achieved when considering sub-samples of "homogenous weather conditions" derived from synoptic circulation classifications: e.g. within almost all of 10 types arising from a classification of

  1. Assistive technology use by disability type and race: exploration of a population-based health survey.

    Science.gov (United States)

    Ilunga Tshiswaka, Daudet; Loggins Clay, Shondra; Chiu, Chung-Yi; Alston, Reginald; Lewis, Allen

    2015-09-28

    To examine the relationships among Assistive Technology (AT) use, race, type of disability and selected other demographic characteristics. Using 2009 National Health Interview Survey, descriptive statistics, statistical interactions and binary logistic regression were performed to identify, contrast and predict the likelihood of using AT based on the type of disability among African Americans (AAs) and European Americans (EAs). We found that more AAs (10% within group proportion of total AAs) used AT compared to EAs (7.5% within group proportion of total EAs). Physical (p disabling conditions that predict the use of AT than AAs, whereas AAs had more demographic characteristics beyond race that predict AT use than EAs. Disparities were observed in AT usage by disability types and demographic characteristics between AAs and EAs. Moreover, the predictive strength of AT usage based on disability types and other demographic variables differed by races. Overall, the findings about the different relationships among race, disability type, and AT use are found. Implications for Rehabilitation The finding may inform the development of initiatives by rehabilitation leaders to encourage the use of AT by AAs and EAs according to their type of impairment. Having identified physical impairment as statistically significant predictor of AT use greater among AAs, rehabilitation leaders should ensure that people living with those types of disability have access to the corresponding type of AT and can use them effectively.

  2. Trap-assisted and Langevin-type recombination in organic light-emitting diodes

    Science.gov (United States)

    Wetzelaer, G. A. H.; Kuik, M.; Nicolai, H. T.; Blom, P. W. M.

    2011-04-01

    Trapping of charges is known to play an important role in the charge transport of organic semiconductors, but the role of traps in the recombination process has not been addressed. Here we show that the ideality factor of the current of organic light-emitting diodes (OLEDs) in the diffusion-dominated regime has a temperature-independent value of 2, which reveals that nonradiative trap-assisted recombination dominates the current. In contrast, the ideality factor of the light output approaches unity, demonstrating that luminance is governed by recombination of the bimolecular Langevin type. This apparent contradiction can be resolved by measuring the current and luminance ideality factor for a white-emitting polymer, where both free and trapped charge carriers recombine radiatively. With increasing bias voltage, Langevin recombination becomes dominant over trap-assisted recombination due to its stronger dependence on carrier density, leading to an enhancement in OLED efficiency.

  3. Parameters in fractional laser assisted delivery of topical anesthetics: Role of laser type and laser settings.

    Science.gov (United States)

    Meesters, Arne A; Nieboer, Marilin J; Kezic, Sanja; de Rie, Menno A; Wolkerstorfer, Albert

    2018-05-07

    Efficacy of topical anesthetics can be enhanced by pretreatment of the skin with ablative fractional lasers. However, little is known about the role of parameters such as laser modality and laser density settings in this technique. Aims of this study were to compare the efficacy of pretreatment with two different ablative fractional laser modalities, a CO 2 laser and an Er:YAG laser, and to assess the role of laser density in ablative fractional laser assisted topical anesthesia. In each of 15 healthy subjects, four 10 × 10 mm test regions on the back were randomized to pretreatment (70-75 μm ablation depth) with CO 2 laser at 5% density, CO 2 laser at 15% density, Er:YAG laser at 5% density or Er:YAG laser at 15% density. Articaine hydrochloride 40 mg/ml + epinephrine 10 μg/ml solution was applied under occlusion to all four test regions. After 15 minutes, a pass with the CO 2 laser (1,500 μm ablation depth) was administered as pain stimulus to each test region. A reference pain stimulus was given on unanesthetized skin. The main outcome parameter, pain, was scored on a 0-10 visual analogue scale (VAS) after each pain stimulus. Median VAS scores were 1.50 [CO 2 5%], 0.50 [CO 2 15%], 1.50 [Er:YAG 5%], 0.43 [Er:YAG 15%], and 4.50 [unanesthetized reference]. VAS scores for all pretreated test regions were significantly lower compared to the untreated reference region (P laser pretreated regions. However, VAS scores were significantly lower at 15% density compared to 5% density for both for the CO 2 laser (P laser (P laser was considered slightly more painful than pretreatment with Er:YAG laser by the subjects. Fractional laser assisted topical anesthesia is effective even with very low energy settings and an occlusion time of only 15 minutes. Both the CO 2 laser and the Er:YAG laser can be used to assist topical anesthesia although the CO 2 laser pretreatment is experienced as more painful. In our study settings, using articaine

  4. TYPES OF POLITICAL REGIMES IN THE IRKUTSK REGION

    Directory of Open Access Journals (Sweden)

    И В Орлова

    2017-12-01

    Full Text Available The authors consider contemporary western and Russian classifications of regional political regimes and their applicability for Russia. Based on the analysis of political theories, the authors chose the traditional typology of regional political regimes focusing on the minimalist interpretation of democracy (electoral competition and methods for identifying regional scenarios introduced by V.Ya. Gelman. The authors study the case of the Irkutsk Region as a region with conflicting elites, in which in a short period several regional heads were replaced. Based on the contemporary political history, the authors analyze the regional political regime using the following criteria: democracy/autocracy, consolidation/oligo-poly, compromise/conflict relations within the ruling elite. The results of the analysis prove the existence of checks and balances in the political system of the Irkutsk Region. Such a system restrains strong politicians attempts to monopolize the political power in the region. When any political player gains too much influence, other centers of power unite against him and together return the situation to the status quo. The political regime of the Irkutsk Region ensures a relatively high level of political competition, at the same time it is a part of the uncompetitive political regime of the Russian Federation, therefore it is a ‘hybrid democracy’. The authors’ analysis of intra-elite relations in the region revealed a high predisposition to conflicts with the dominant scenario of ‘war of all against all’.

  5. Grain boundary composition and irradiation-assisted stress corrosion cracking resistance in Type 348 stainless steel

    International Nuclear Information System (INIS)

    Jacobs, A.J.; Wozadlo, G.P.; Nakata, K.

    1994-01-01

    Scanning transmission electron microscopy (STEM) analyses, in-reactor swelling mandrel tests, and laboratory constant extension rate tensile (CERT) tests were conducted on nine custom type 348 (UNS S34800) stainless steel (SS) alloys in an attempt to correlate grain boundary composition with irradiation-assisted stress corrosion cracking (IASCC) resistance. Phosphorus (P) enrichment showed the best correlation with in-reactor test results, and chromium (Cr) depletion showed the best correlation with laboratory results. Silicon (Si) and P enrichment were found to depend quantitatively on the bulk concentrations of these elements. The amount of Cr depletion seemed dependent at least partially on the amounts of Si and/or P enrichment. Si and P enrichment and Cr depletion were suppressed by higher carbon (C) contents, such as that present in commercial-purity type 348 SS

  6. Brain Region and Cell Type Transcripts for Informative Diagnostics

    Science.gov (United States)

    2010-09-01

    related with neurological condition and is on average larger in patients with schizophrenia and bipolar disorder. The blue circle region represents the...in a number of neurological conditions. Furthermore, this region is usually larger for schizophrenia , bipolar disorder, and Alzheimer’s disease...pathways such as calcium signaling pathway, mapK signaling pathway, Gaba pathway, and long- term depression pathways etc., are confirmed pathways through

  7. Electronic health records and technical assistance to improve quality of primary care: Lessons for regional extension centers.

    Science.gov (United States)

    Boas, Samuel J; Bishop, Tara F; Ryan, Andrew M; Shih, Sarah C; Casalino, Lawrence P

    2014-07-01

    In 2009, the American Recovery and Reinvestment Act apportioned $643 million for a Health Information Technology Extension Program, which established Regional Extension Centers (RECs) to support the implementation and use of electronic health records (EHRs). Little is known, however, about how RECs should assist in EHR implementation and how they should structure ongoing support. The purpose of this paper is to describe physicians' experiences with the Primary Care Information Project (PCIP), an REC run by the New York City Department of Health and Mental Hygiene. We interviewed 17 physicians enrolled in PCIP to understand the role of the EHRon quality of care and their experience with technical assistance from PCIP. All physicians stated that they felt that the EHR improved the quality of care they delivered to their patients particularly because it helped them track patients. All the physicians found technical assistance helpful but most wanted ongoing assistance months or years after they adopted the EHR. © 2013 Published by Elsevier Inc.

  8. Diet of otters (Lutra lutra in various habitat types in the Pannonian biogeographical region compared to other regions of Europe

    Directory of Open Access Journals (Sweden)

    József Lanszki

    2016-08-01

    Full Text Available Knowledge of the effect of habitat type and region on diet and feeding behaviours of a species facilitates a better understanding of factors impacting populations, which contributes to effective conservation management. Using spraint analysis and relative frequency of occurrence data from the literature, we described the dietary patterns of Eurasian otters (Lutra lutra in 23 study sites within the Pannonian biogeographical region in Hungary. Our results indicated that diet composition varied by habitat type and is therefore context dependant. The differences among habitat types were however lower than expected. We noticed a decline in the fish consumption with a concomitant increase in trophic niche breadth and amphibian consumption in rivers, ponds (fish farms, backwaters, marshes and small watercourses. The main differences in diet were not attributed to the consumption of primary and secondary food types (fish and amphibians, but rather to differences in other, less important food types (mammals, birds. Using hierarchical cluster analysis, rivers and ponds could clearly be separated from other habitat types. We found the main fish diet of otters in most of these areas consisted of small (<100 g, eurytopic, littoral and non-native, mostly invasive species. Dietary studies from 91 sites in six European biogeographical regions showed that fish are consumed most frequently in the Atlantic and Boreal, less in the Continental and Pannonian, and least in the Alpine and Mediterranean regions. Comparative analysis indicated that the Mediterranean region (with frequent crayfish consumption and Alpine region (frequent amphibian consumption cluster separate from the other regions.

  9. Regional Moment Tensor Source-Type Discrimination Analysis

    Science.gov (United States)

    2015-11-16

    unique normalized eigenvalues (black ‘+’ signs) or unique source-types on (a) the fundamental Lune (Tape and Tape, 2012a,b), and (b) on the Hudson...Solutions color-coded by variance reduction (VR) pre- sented on the Tape and Tape (2012a) and Tape and Tape (2012b) Lune . The white circle...eigenvalues (black ‘+’ signs) or unique source-types on (a) the fundamental Lune (Tape and Tape, 2012a,b), and (b) on the Hudson source-type plot (Hudson

  10. Effect of Gas Tungsten Arc Welding Parameters on Hydrogen-Assisted Cracking of Type 321 Stainless Steel

    Science.gov (United States)

    Rozenak, Paul; Unigovski, Yaakov; Shneck, Roni

    2016-05-01

    The susceptibility of AISI type 321 stainless steel welded by the gas tungsten arc welding (GTAW) process to hydrogen-assisted cracking (HAC) was studied in a tensile test combined with in situ cathodic charging. Specimen charging causes a decrease in ductility of both the as-received and welded specimens. The mechanical properties of welds depend on welding parameters. For example, the ultimate tensile strength and ductility increase with growing shielding gas (argon) rate. More severe decrease in the ductility was obtained after post-weld heat treatment (PWHT). In welded steels, in addition to discontinuous grain boundary carbides (M23C6) and dense distribution of metal carbides MC ((Ti, Nb)C) precipitated in the matrix, the appearance of delta-ferrite phase was observed. The fracture of sensitized specimens was predominantly intergranular, whereas the as-welded specimens exhibited mainly transgranular regions. High-dislocation density regions and stacking faults were found in delta-ferrite formed after welding. Besides, thin stacking fault plates and epsilon-martensite were found in the austenitic matrix after the cathodic charging.

  11. A twin sibling with Prader-Willi syndrome caused by type 2 microdeletion following assisted reproductive technology: A case report.

    Science.gov (United States)

    Han, Ji Yoon; Park, Joonhong; Jang, Woori; Chae, Hyojin; Kim, Myungshin; Kim, Yonggoo

    2016-07-01

    Prader-Willi syndrome (PWS) is a neurobehavioral imprinting disorder, which arises due to an absence of paternally expressed genes within the 15q11.2-q13 region. This occurs via one of the three main genetic mechanisms, as follows: Deletion of the paternally inherited 15q11.2-q13 region, maternal uniparental disomy and imprinting defect. Recent studies have reported an association between imprinting disorders and assisted reproductive technologies (ART). The current study presents a 6-year-old female patient who is a dizygotic twin, in which one was born with de novo microdeletion at 15q11.2-q13.1 following in vitro fertilization. The patient had characteristic facial features including narrow bifrontal diameter, strabismus, downturned mouth, feeding problems and generalized hypotonia during infancy, developmental delay, mental retardation and rapid weight gain. Based upon phenotypic resemblance and the medical records, methylation-specific multiplex ligation-dependent probe amplification and array-based comparative genome hybridization analyses demonstrate type 2 microdeletion between breaking point 2 (BP2) and BP3, which occur from MKRN3 through HERC2 at 15q11.2-q13.1. To the best of our knowledge, the present study is the first to report a PWS case born following ART reported in South Korea. In addition to previous studies, the present study contributes to the consensus regarding genotype-phenotype comparisons in this respect.

  12. Type of aphasia and regional cerebral blood flow

    International Nuclear Information System (INIS)

    Tagawa, Koichi; Sugimoto, Keiko; Minematsu, Kazuo; Yamaguchi, Takenori; Naritomi, Hiroaki; Sawada, Tohru

    1982-01-01

    In 40 patients with aphasia due to cerebral infarction, regional cerebral blood flow (rCBF) was measured after 2 months of ictus with 133 Xe inhalation method. There were 18 cases with motor aphasia and 22 with sensory aphasia. On the measurements of rCBF, 3 detectors were placed over frontal region (group F), 3 over temporal region (group T), and remaining 3 over parietal region (group P), of the dominant hemisphere. The flow values were compared with the rCBF values obtained from 21 control subjects who had no abnormality in CT scan and on neurological examinations. The control subjects revealed the hyperfrontal pattern of flow distribution; rCBF values in groups F, T and P, which were expressed as an initial slope index, were 50.0 +- 4.8, 48.0 +- 5.1 and 47.4 +- 4.5, respectively. The hyperfrontal pattern was absent in cases with motor aphasia. In this group, rCBF in groups F, T and P were 42.0 +- 8.3, 44.7 +- 8.4 and 41.0 +- 8.5, respectively, and rCBF in frontal region was significantly reduced compared with that in the control group. In sensory aphasia, rCBF values in groups F, T and P were all significantly reduced compared to the controls showing 44.0 +- 5.7, 42.8 +- 5.1 and 40.6 +- 5.4, respectively. In this group, the hyperfrontal pattern was maintained at a low flow level. When absolute rCBF values were compared between motor and sensory aphasia, there was no significant difference between these 2 groups. However, regional flow distribution in motor aphasia was significantly different from that of sensory aphasia, and the cases having the lowest value in group F were more frequently found in the former than in the latter. (J.P.N.)

  13. 45 CFR 286.55 - What types of costs are subject to the administrative cost limit on Tribal Family Assistance...

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What types of costs are subject to the... § 286.55 What types of costs are subject to the administrative cost limit on Tribal Family Assistance... tracking, data entry and monitoring, including personnel and other costs associated with the automation...

  14. 24 CFR 906.5 - Dwelling units and types of assistance that a PHA may make available under a homeownership...

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Dwelling units and types of... HOUSING HOMEOWNERSHIP PROGRAMS Basic Program Requirements § 906.5 Dwelling units and types of assistance... for financing to eligible families (see § 905.15 of this title) purchasing dwelling units eligible...

  15. Photoacoustic microscopy of complex regional pain syndrome type I (CRPS-1) after stellate ganglion blocks in vivo

    Science.gov (United States)

    Zhou, Yong; Yi, Xiaobin; Xing, Wenxin; Hu, Song; Maslov, Konstantin I.; Wang, Lihong V.

    2015-03-01

    We used photoacoustic microscopy (PAM) to assist diagnoses and monitor the progress and treatment outcome of complex regional pain syndrome type 1 (CRPS-1). Blood vasculature and oxygen saturation (sO2) were imaged by PAM in eight adult patients with CRPS-1. Patients' hands and cuticles were imaged both before and after stellate ganglion block (SGB) for comparison. For all patients, both the vascular structure and sO2 could be assessed by PAM. In addition, more vessels and stronger signals were observed after SGB.

  16. A powerful method for transcriptional profiling of specific cell types in eukaryotes: laser-assisted microdissection and RNA sequencing.

    Directory of Open Access Journals (Sweden)

    Marc W Schmid

    Full Text Available The acquisition of distinct cell fates is central to the development of multicellular organisms and is largely mediated by gene expression patterns specific to individual cells and tissues. A spatially and temporally resolved analysis of gene expression facilitates the elucidation of transcriptional networks linked to cellular identity and function. We present an approach that allows cell type-specific transcriptional profiling of distinct target cells, which are rare and difficult to access, with unprecedented sensitivity and resolution. We combined laser-assisted microdissection (LAM, linear amplification starting from <1 ng of total RNA, and RNA-sequencing (RNA-Seq. As a model we used the central cell of the Arabidopsis thaliana female gametophyte, one of the female gametes harbored in the reproductive organs of the flower. We estimated the number of expressed genes to be more than twice the number reported previously in a study using LAM and ATH1 microarrays, and identified several classes of genes that were systematically underrepresented in the transcriptome measured with the ATH1 microarray. Among them are many genes that are likely to be important for developmental processes and specific cellular functions. In addition, we identified several intergenic regions, which are likely to be transcribed, and describe a considerable fraction of reads mapping to introns and regions flanking annotated loci, which may represent alternative transcript isoforms. Finally, we performed a de novo assembly of the transcriptome and show that the method is suitable for studying individual cell types of organisms lacking reference sequence information, demonstrating that this approach can be applied to most eukaryotic organisms.

  17. Photo-assisted Fenton type processes for the degradation of phenol: A kinetic study

    International Nuclear Information System (INIS)

    Kusic, Hrvoje; Koprivanac, Natalija; Bozic, Ana Loncaric; Selanec, Iva

    2006-01-01

    In this study the application of advanced oxidation processes (AOPs), dark Fenton and photo-assisted Fenton type processes; Fe 2+ /H 2 O 2 , Fe 3+ /H 2 O 2 , Fe 0 /H 2 O 2 , UV/Fe 2+ /H 2 O 2 , UV/Fe 3+ /H 2 O 2 and UV/Fe 0 /H 2 O 2 , for degradation of phenol as a model organic pollutant in the wastewater was investigated. A detail kinetic modeling which describes the degradation of phenol was performed. Mathematical models which predict phenol decomposition and formation of primary oxidation by-products: catechol, hydroquinone and benzoquinone, by applied processes were developed. The study also consist the modeling of mineralization kinetic of the phenol solution by applied AOPs. This part, besides well known reactions of Fenton and photo-Fenton chemistry, involves additional reactions which describe removal of iron from catalytic cycle through formation of ferric complexes and its regeneration induced by UV radiation. Phenol decomposition kinetic was monitored by HPLC analysis and total organic carbon content measurements (TOC). Complete phenol removal was obtained by all applied processes. Residual TOC by applied Fenton type processes ranged between 60.2 and 44.7%, while the efficiency of those processes was significantly enhanced in the presence of UV light, where residual TOC ranged between 15.2 and 2.4%

  18. [Vacuum-assisted therapy for various wound types including diabetic foot ulcer].

    Science.gov (United States)

    Farah, Raymond; Gantus, Maher; Kogan, Leonid

    2011-03-01

    Vacuum is a noninvasive system that creates a localized controlled negative pressure environment. In this study, vacuum was provided by the V.A.C. Therapy system, which promotes wound healing by delayed primary or secondary intention through creating a moist wound environment, preparing the wound bed for closure, reducing edema, and promoting formation and perfusion of granulation tissue. Vacuum-assisted closure therapy is indicated for use in all care settings and for a variety of wound types including diabetic foot ulcers. The purpose of this study was to evaluate safety and clinical efficacy of negative pressure wound therapy (NPWT) compared with advanced moist wound therapy and standard treatment to treat foot ulcers in diabetic patients. This trial enrolled 43 patients; most of them were diabetic patients at any age with various skin ulcers and diabetic foot. These patients were divided into two groups, 17 patients were treated with vacuum and the 26 patients in the control group were treated with standard therapy including debridement. A greater proportion of foot and skin ulcers achieved complete ulcer closure with vacuum-assisted therapy p<0.001 compared with the standard therapy. Vacuum therapy significantly decreased the duration and frequency of admission p=0.032 and decreased the rate of amputation p<0.001. Results of our trial support other studies and demonstrate that vacuum is as safe as and more efficacious than standard therapy in the treatment of diabetic foot ulcers. A significantly greater number of patients achieved complete ulcer closure and granulation tissue formation with this therapy. The study group showed a significant reduction in the median time needed to heal ulcers, reduction of the number of admissions and amputation frequency.

  19. [The computer assisted pacemaker clinic at the regional hospital of Udine (author's transl)].

    Science.gov (United States)

    Feruglio, G A; Lestuzzi, L; Carminati, D

    1978-01-01

    For a close follow-up of large groups of pacemaker patients and for evaluation of long term pacing on a reliable statistical basis, many pacemaker centers in the world are now using computer systems. A patient data system with structured display records, designed to give complete, comprehensive and surveyable information and which are immediately retrievable 24 hours a day, on display or printed sets, seems to offer an ideal solution. The pacemaker clinic at the Regional Hospital of Udine has adopted this type of system. The clinic in linked to a live, on-line patient data system (G/3, Informatica Friuli-Venezia Giulia). The input and retrieval of information are made through a conventional keyboard. The input formats have fixed headings with coded alternatives and a limited space for comments in free text. The computer edits the coded information to surveyable reviews. Searches can be made on coded information and data of interest.

  20. Effect of Regional Hospital Competition and Hospital Financial Status on the Use of Robotic-Assisted Surgery.

    Science.gov (United States)

    Wright, Jason D; Tergas, Ana I; Hou, June Y; Burke, William M; Chen, Ling; Hu, Jim C; Neugut, Alfred I; Ananth, Cande V; Hershman, Dawn L

    2016-07-01

    Despite the lack of efficacy data, robotic-assisted surgery has diffused rapidly into practice. Marketing to physicians, hospitals, and patients has been widespread, but how this marketing has contributed to the diffusion of the technology remains unknown. To examine the effect of regional hospital competition and hospital financial status on the use of robotic-assisted surgery for 5 commonly performed procedures. A cohort study of 221 637 patients who underwent radical prostatectomy, total nephrectomy, partial nephrectomy, hysterectomy, or oophorectomy at 1370 hospitals in the United States from January 1, 2010, to December 31, 2011, was conducted. The association between hospital competition, hospital financial status, and performance of robotic-assisted surgery was examined. The association between hospital competition was measured with the Herfindahl-Hirschman Index (HHI), hospital financial status was estimated as operating margin, and performance of robotic-assisted surgery was examined using multivariate mixed-effects regression models. We identified 221 637 patients who underwent one of the procedures of interest. The cohort included 30 345 patients who underwent radical prostatectomy; 20 802, total nephrectomy; 8060, partial nephrectomy; 134 985, hysterectomy; and 27 445, oophorectomy. Robotic-assisted operations were performed for 20 500 (67.6%) radical prostatectomies, 1405 (6.8%) total nephrectomies, 2759 (34.2%) partial nephrectomies, 14 047 (10.4%) hysterectomies, and 1782 (6.5%) oophorectomies. Use of robotic-assisted surgery increased for each procedure from January 2010 through December 2011. For all 5 operations, increased market competition (as measured by the HHI) was associated with increased use of robotic-assisted surgery. For prostatectomy, the risk ratios (95% CIs) for undergoing a robotic-assisted procedure were 2.20 (1.50-3.24) at hospitals in moderately competitive markets and 2.64 (1.84-3.78) for highly competitive markets

  1. NPL-PAD (National Priorities List Publication Assistance Database) for Region 7

    Data.gov (United States)

    U.S. Environmental Protection Agency — THIS DATA ASSET NO LONGER ACTIVE: This is metadata documentation for the National Priorities List (NPL) Publication Assistance Databsae (PAD), a Lotus Notes...

  2. Pattern and impact of the Agency's technical assistance programme in the Asia and Pacific Region

    International Nuclear Information System (INIS)

    Nethsinghe, D.A.

    1979-01-01

    The main objectives of the Agency's technical assistance programmes are to promote the transfer of skills and knowledge relating to the peaceful uses of atomic energy to developing countries, to support the efforts of these countries to carry out their atomic energy activities safely and more efficiently, and to ensure that the technology transferred can continue to be applied usefully after the Agency's assistance has been completed. The assistance can be in the form of fellowship awards for training, for expert and consulting services, and for equipment. It may cover a wide range of scientific and technical fields. The impact of the Agency's technical assistance in several of these fields, i.e., reactors and power plants, prospecting for uranium and other raw materials, agriculture, industrial applications, and nuclear medicine, are reviewed

  3. "Activity Types" and "Discourse Types": Mediating "Advice" in Interactions between Foreign Language Assistants and Their Supervisors in Schools in France and England

    Science.gov (United States)

    Culpeper, Jonathan; Crawshaw, Robert; Harrison, Julia

    2008-01-01

    This paper aims to enhance our understanding of interactions between French/English Foreign Language Assistants (FLAs) and their school mentors (MEs), and, more specifically, of how "advice" is sought, given and received. More generally, it will articulate a pragmatic approach (employing the notion of "activity type") that can…

  4. Solar greenhouse assisted biogas plant in hilly region - A field study

    Energy Technology Data Exchange (ETDEWEB)

    Vinoth Kumar, K.; Kasturi Bai, R. [Department of Bio-Energy, School of Energy, Environment and Natural Resources, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu (India)

    2008-10-15

    The present study was undertaken with the objective of evaluating plastic as an alternative material for biogas plant on a par with conventional brick material. The field study was carried out for one year (October, 2005-September, 2006) in a small hamlet at Nilgiris incorporating solar energy to study its influence on biogas production. During summer (April-June) the temperature reaches to the maximum of 21-25 C and the minimum of 10-12 C. During winter (October-December), the temperature available is maximum of 16-21 C and minimum of 2 C. The solar insolation in the study area ranges from 250 to 600 W/m{sup 2}. This study involves the control conventional Deenabandhu model (Indian standard model prevailing in most part of India made of masonry structure only) and the experimental plastic tank with greenhouse canopy of similar capacity. Our previous work [Vinoth Kumar, K., Kasturi Bai, R., 2005. Plastic biodigesters - a systematic study. Energy for Sustainable Development 9 (4), 40-49] on lab scale digester made from plastic material was compared over other materials and the results gave us much confidence to carry out further study on pilot scale. In continuation, a semi-continuous study was conducted for one year with the retention time of 55 days. The gas generated from the biogas plants was utilized for cooking (burner) and lighting (lamp) purposes. The yearly average slurry temperatures recorded during the study period was 26.3 and 22.4 C in experimental and control biogas plants against ambient temperature of 17.0 C. The yearly average greenhouse chamber temperature recorded was 29.1 C in the experimental biogas plant. The yearly average gas yield from the experimental and control biogas plants were 39.1 and 34.6 l kg{sup -1}day{sup -1} respectively. Gas productions in the winter season registered lower than other months. It can be concluded that the solar greenhouse assisted plastic biogas plant can be efficiently adopted with minor modifications in hilly

  5. Magnetic suspension of the rotor of a ventricular assist device of mixed flow type.

    Science.gov (United States)

    Horikawa, Oswaldo; de Andrade, Aron José Pazin; da Silva, Isaías; Bock, Eduardo Guy Perpetuo

    2008-04-01

    This work presents results of preliminary studies concerning application of magnetic bearing in a ventricular assist device (VAD) being developed by Dante Pazzanese Institute of Cardiology-IDPC (São Paulo, Brazil). The VAD-IDPC has a novel architecture that distinguishes from other known VADs. In this, the rotor has a conical geometry with spiral impellers, showing characteristics that are intermediate between a centrifugal VAD and an axial VAD. The effectiveness of this new type of blood pumping principle was showed by tests and by using it in heart surgery for external blood circulation. However, the developed VAD uses a combination of ball bearings and mechanical seals, limiting the life for some 10 h, making impossible its long-term use or its use as an implantable VAD. As a part of development of an implantable VAD, this work aims at the replacement of ball bearings by a magnetic bearing. The most important magnetic bearing principles are studied and the magnetic bearing developed by Escola Politécnica of São Paulo University (EPUSP-MB) is elected because of its very simple architecture. Besides presenting the principle of the EPUSP-MB, this work presents one possible alternative for applying the EPUSP-MB in the IDPC-VAD.

  6. The impact of different types of assistive devices on gait measures and safety in Huntington's disease.

    Directory of Open Access Journals (Sweden)

    Anne D Kloos

    Full Text Available BACKGROUND: Gait and balance impairments lead to frequent falls and injuries in individuals with Huntington's disease (HD. Assistive devices (ADs such as canes and walkers are often prescribed to prevent falls, but their efficacy is unknown. We systematically examined the effects of different types of ADs on quantitative gait measures during walking in a straight path and around obstacles. METHODS: Spatial and temporal gait parameters were measured in 21 subjects with HD as they walked across a GAITRite walkway under 7 conditions (i.e., using no AD and 6 commonly prescribed ADs: a cane, a weighted cane, a standard walker, and a 2, 3 or 4 wheeled walker. Subjects also were timed and observed for number of stumbles and falls while walking around two obstacles in a figure-of-eight pattern. RESULTS: Gait measure variability (i.e., coefficient of variation, an indicator of fall risk, was consistently better when using the 4WW compared to other ADs. Subjects also walked the fastest and had the fewest number of stumbles and falls when using the 4WW in the figure-of-eight course. Subjects walked significantly slower using ADs compared to no AD both across the GAITRite and in the figure-of-eight. Measures reflecting gait stability and safety improved with the 4WW but were made worse by some other ADs.

  7. The impact of different types of assistive devices on gait measures and safety in Huntington's disease.

    Science.gov (United States)

    Kloos, Anne D; Kegelmeyer, Deborah A; White, Susan E; Kostyk, Sandra K

    2012-01-01

    Gait and balance impairments lead to frequent falls and injuries in individuals with Huntington's disease (HD). Assistive devices (ADs) such as canes and walkers are often prescribed to prevent falls, but their efficacy is unknown. We systematically examined the effects of different types of ADs on quantitative gait measures during walking in a straight path and around obstacles. Spatial and temporal gait parameters were measured in 21 subjects with HD as they walked across a GAITRite walkway under 7 conditions (i.e., using no AD and 6 commonly prescribed ADs: a cane, a weighted cane, a standard walker, and a 2, 3 or 4 wheeled walker). Subjects also were timed and observed for number of stumbles and falls while walking around two obstacles in a figure-of-eight pattern. Gait measure variability (i.e., coefficient of variation), an indicator of fall risk, was consistently better when using the 4WW compared to other ADs. Subjects also walked the fastest and had the fewest number of stumbles and falls when using the 4WW in the figure-of-eight course. Subjects walked significantly slower using ADs compared to no AD both across the GAITRite and in the figure-of-eight. Measures reflecting gait stability and safety improved with the 4WW but were made worse by some other ADs.

  8. Pathological confirmation of nerve-sparing types performed during robot-assisted radical prostatectomy (RARP).

    Science.gov (United States)

    Ko, Woo Jin; Hruby, Gregory W; Turk, Andrew T; Landman, Jaime; Badani, Ketan K

    2013-03-01

    WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Incremental nerve-sparing techniques (NSTs) improve postoperative erectile function after robot-assisted radical prostatectomy (RARP). However, there are no studies to date that histologically confirm the surgeon intended NST. Thus, in the present study, we histologically confirmed that the surgeon performed the nerve preservation as his intended NSTs during RARP. Also, we found that there was more variability in fascia width outcome on the left side compared with the right. Therefore, when performing nerve preservation on the surgeon's non-dominant side, we need to pay more close attention. To confirm that the surgeon achieved true intended histological nerve sparing during robot-assisted radical prostatectomy (RARP) by studying RP specimens. To aid the novice robotic surgeon to develop the skills of RARP. Between June 2008 and May 2009, 122 consecutive patients underwent RARP by a single surgeon (K.K.B.). The degree of nerve sparing (wide resection [WR], interfascial nerve sparing [ITE-NS], intrafascial nerve sparing [ITR-NS]) on both sides was recorded. The posterior sectors of RP specimens from distal, mid, and proximal parts were evaluated. Fascia width (FW) of each position in RP specimens were compared across nerve-sparing types (NSTs). FW was recorded at 15 ° intervals (3-9 o'clock position), measured as the distance between the outermost prostate gland and surgical margin. The slides were reviewed by an experienced uropathologist who was 'blinded' to the NST. In all, 93 men were included. The overall mean (sd) FW was the greatest in the order of WR, ITE-NS, and ITR-NS, at 2.42 (1.62), 1.71 (1.40) and 1.16 (1.08) mm, respectively (P ITE-NS, bilateral ITE-NS, ITE-NS/WR, and bilateral WR, respectively. To further validate and confirm these preliminary findings, additional studies involving multicentre cohorts would be required. The surgeon intended dissection and FW correlate, with ITR

  9. 22 CFR Appendix C to Part 218 - List of Types of Federal Financial Assistance

    Science.gov (United States)

    2010-04-01

    ... universities and colleges in the United States to develop their capabilities to assist developing countries in agricultural teaching, research and extension services. (Section 297, Foreign Assistance Act of 1961, as... by AID Subject to Age Discrimination Regulations 1. Grants to research and educational institutions...

  10. Regional organization of fibre types in normal and reinnervated hindlimb muscles

    NARCIS (Netherlands)

    Wang, Liangchun

    2001-01-01

    The present thesis concerns the spatial distribution of the "slow" type I fibres within muscles of the hindlimb. It is known since long ago that some muscles may have strikingly heterogeneous distributions of type I and II fibres, but this phenomenon of "fibre type regionalization" has still not

  11. Towards the Development of an Automated Learning Assistant for Vector Calculus: Integration over Planar Regions

    Science.gov (United States)

    Yaacob, Yuzita; Wester, Michael; Steinberg, Stanly

    2010-01-01

    This paper presents a prototype of a computer learning assistant ILMEV (Interactive Learning-Mathematica Enhanced Vector calculus) package with the purpose of helping students to understand the theory and applications of integration in vector calculus. The main problem for students using Mathematica is to convert a textbook description of a…

  12. Characterization of two types of azedinha in the region of Sete Lagoas, Brazil

    OpenAIRE

    Silva,Ernani C da; Carlos,Lanamar de A; Araújo,Ana Paula; Ferraz,Leila de CL; Pedrosa,Marinalva W; Silva,Luana Sabrine

    2013-01-01

    Azedinha (Rumex acetosa) is a vegetable crop species consumed in natura in salads and pertains to the group of non-conventional vegetables. These rustic plants are often considered weeds plants. There exist two types of native azedinha in the Sete Lagoas region, Minas Gerais state, Brazil, that are usually grown in family gardens and here denominated Type I and Type II. In this study we characterized the morphologic, physic-chemical and chromatic characteristic of these two types of azedinha....

  13. 22 CFR Appendix B to Part 218 - List of Types of Federal Financial Assistance

    Science.gov (United States)

    2010-04-01

    ... by the United States International Communication Agency Subject to Age Discrimination Regulations... BASIS OF AGE IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Pt. 218, App. B Appendix B...

  14. Inversion of the chromosomal region between two mating type loci switches the mating type in Hansenula polymorpha.

    Science.gov (United States)

    Maekawa, Hiromi; Kaneko, Yoshinobu

    2014-11-01

    Yeast mating type is determined by the genotype at the mating type locus (MAT). In homothallic (self-fertile) Saccharomycotina such as Saccharomyces cerevisiae and Kluveromyces lactis, high-efficiency switching between a and α mating types enables mating. Two silent mating type cassettes, in addition to an active MAT locus, are essential components of the mating type switching mechanism. In this study, we investigated the structure and functions of mating type genes in H. polymorpha (also designated as Ogataea polymorpha). The H. polymorpha genome was found to harbor two MAT loci, MAT1 and MAT2, that are ∼18 kb apart on the same chromosome. MAT1-encoded α1 specifies α cell identity, whereas none of the mating type genes were required for a identity and mating. MAT1-encoded α2 and MAT2-encoded a1 were, however, essential for meiosis. When present in the location next to SLA2 and SUI1 genes, MAT1 or MAT2 was transcriptionally active, while the other was repressed. An inversion of the MAT intervening region was induced by nutrient limitation, resulting in the swapping of the chromosomal locations of two MAT loci, and hence switching of mating type identity. Inversion-deficient mutants exhibited severe defects only in mating with each other, suggesting that this inversion is the mechanism of mating type switching and homothallism. This chromosomal inversion-based mechanism represents a novel form of mating type switching that requires only two MAT loci.

  15. «Resource type» regions in the modern Russian economy

    Directory of Open Access Journals (Sweden)

    Levin Sergey, N.

    2015-06-01

    Full Text Available Despite the officially declared intention to form universal rules of the liberal type, development was based on the formation of a "hybrid" institutional environment in the "post-Soviet" transformation of the Russian economy. "Hybrid" institutional environment is characterized, firstly, with the prevalence of forms of interaction between authorities and business that are uncharacteristic for liberal market economy, and their "merging" with each other, secondly, with sustainable regional fragmentation. As a result regional institutional systems, based on different configurations of network linkages between business and authorities, appeared and embedded into unified «power vertical». «Resource type» regions occupy special position in the modern Russian economy. Their economies are based on the export-oriented industries as well as raw resources extracting and mining industries. We distinguish the following discrete structural alternatives of their development in a globalizing economy: "enclave dual economy" and integrated regional economy. The first option is institutionally reinforces the social and economic gap from developed countries. The second one provides diversification and development of regional and national economies. We use comparative characteristic of Kemerovo region and Krasnoyarsk region to carry out analysis of options of "resource type" regions development. We selected indicators and elaborated estimation algorithm to figure out the type of regional economic development.

  16. Regional analgesia for video-assisted thoracic surgery – a systematic review

    DEFF Research Database (Denmark)

    Julia Steinthorsdottir, Kristin; Wildgaard, Lorna; Jessen Hansen, Henrik

    2013-01-01

    there is no gold standard for regional analgesia for VATS. This systematic review aimed to assess different regional techniques in regards to effect on acute post-operative pain following VATS, with emphasis on VATS lobectomy. The systematic review of the PubMed, Cochrane Library and Embase databases yielded...... be demonstrated, but a guide of factors to include in future studies on regional analgesia for VATS is presented....

  17. The early noncoding region of human papillomavirus type 16 is regulated by cytoplasmic polyadenylation factors

    DEFF Research Database (Denmark)

    Glahder, Jacob-Andreas Harald; Kristiansen, Karen; Durand, Marjorie

    2010-01-01

    All human papillomavirus type 16 (HPV-16) early mRNAs are polyadenylated at the poly(A) signal within the early 3' untranslated region (3'UTR). The 3'end of the early E5 open reading frame and the 3'UTR of HPV-16 is very AU-rich, with five regions similar to cytoplasmic polyadenylation elements (...

  18. What type of regional policy for Europe? Theoretical reflections and policy lessons from Sardinia

    NARCIS (Netherlands)

    Hospers, Gerrit J.; Benneworth, Paul Stephen

    2005-01-01

    In promoting European regional development, policymakers tend to pursue either an offensive, future-oriented or a defensive, tradition-preserving type of policy. Backed by theoretical notions and case evidence from an “ordinary” region, i. e. the Italian island of Sardinia, the following paper

  19. Transcriptional activation by the E1A regions of adenovirus types 40 and 41

    NARCIS (Netherlands)

    Loon, A.E. van; Gilardi, P.; Perricaudet, M.; Rozijn, Th. H.; Sussenbach, J.S.

    In order to establish whether the poor growth of the two fastidious adenoviruses types 40 and 41 (Ad40 and Ad41) in HeLa cells is due to a reduced trans-activation by the early region to (E1A), we have determined the trans-activating effect of this region on the expression of the chloramphenicol

  20. Fiscal 2000 achievement report on the venture business assisting type regional consortium - Core industry creation type. Research and development of energy conservation oriented collective detoxification system for dioxins and toxic heavy metals in fly ash and soil; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo seika hokokusho. Hibai dojochu no dioxin rui yugai jukinzoku no sho energy gata ikkatsu mugaika shori system ni kansuru kenkyu kaihatsu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-03-01

    Efforts are made to develop a system to collectively detoxify dioxins and heavy metals in incinerator fly ash or in polluted soil using microbes and/or chemicals. In the use of chemicals, verification tests are conducted for a system to detoxify dioxins and toxic heavy metals simultaneously. In the use of microbes, an effort is made to develop a low cost energy conservation type treatment system based on what is provided by the study of microbes such as Phanerochaete chrysosporium. As for the treatment of fly ash, an effort is made to recycle it into resources usable in the development of marketable products. For the detoxification of dioxins using chemicals, they are dechlorinated in a chemical reduction reaction. For their detoxification with help of microbes, it is found in an experiment of ash fly dioxin decomposition using Phanerochaete chrysosporium that the microbe reduces dioxins in both liquid phase and solid phase systems. The result of verification tests using chemicals shows that the reference level of 3ng-TEQ/g is easily cleared in the treatment of high concentration ash fly. In the detoxification of heavy metals, data is obtained indicating that the elution level of lead in ash fly is found reduced by 70-85% after treatment. (NEDO)

  1. Analysis on metallogenic conditions of paleochannel sandstone type uranium deposits in kelulun region

    Energy Technology Data Exchange (ETDEWEB)

    Mingyue, Feng [Beijing Research Inst. of Uranium Geology, Beijing (China)

    1999-07-01

    On the basis of comprehensively analyzing metallogenic conditions of paleochannel sandstone type uranium deposits, the author discusses regional geologic background, characteristics of the basement and sedimentary cover of Kelulun basin and Huchawula-Hulun Lake basin, and the metallogenic potential of paleochannel sandstone type uranium deposits is proposed.

  2. Analysis on metallogenic conditions of paleochannel sandstone type uranium deposits in kelulun region

    International Nuclear Information System (INIS)

    Feng Mingyue

    1999-01-01

    On the basis of comprehensively analyzing metallogenic conditions of paleochannel sandstone type uranium deposits, the author discusses regional geologic background, characteristics of the basement and sedimentary cover of Kelulun basin and Huchawula-Hulun Lake basin, and the metallogenic potential of paleochannel sandstone type uranium deposits is proposed

  3. Severe hypoglycaemia during treatment with sulphonylureas in patients with type 2 diabetes in the Capital Region of Denmark

    DEFF Research Database (Denmark)

    Pilemann-Lyberg, S; Thorsteinsson, B; Snorgaard, O

    2015-01-01

    AIMS: Sulphonylureas (SU) are currently recommended as a well-established second line treatment in guidelines for type 2 diabetes (T2DM). In the Capital Region of Denmark 16,865 patients were given SU as part of their treatment of T2DM in 2010-2011. To what extent SU are associated...... with hospitalizations due to severe hypoglycaemic episodes, defined as episodes with a need for external assistance, was investigated. The prevalence and characteristics of these patients and potential risk factors were studied. METHODS: ICD-10 diagnosis codes were used to identify patients hospitalized due...... to hypoglycaemia and T2DM for a period of 2 years (2010-2011). Inclusion criteria were T2DM, hospitalization due to hypoglycaemia and treatment with SU as monotherapy or in combination with other glucose-lowering drugs except insulin treatment. RESULTS: We identified 161 patients fulfilling the inclusion criteria...

  4. Secondary typing of Mycobacterium tuberculosis isolates with matching IS6110 fingerprints from different geographic regions of the United States.

    Science.gov (United States)

    Yang, Z H; Bates, J H; Eisenach, K D; Cave, M D

    2001-05-01

    Fifty-nine isolates of Mycobacterium tuberculosis obtained from different states in the United States and representing 25 interstate clusters were investigated. These clusters were identified by computer-assisted analysis of DNA fingerprints submitted during 1996 and 1997 by different laboratories participating in the CDC National Genotyping and Surveillance Network. Isolates were fingerprinted with the IS6110 right-hand probe (IS6110-3'), the IS6110 left-hand probe (IS6110-5'), and the probe pTBN12, containing the polymorphic GC-rich sequence (PGRS). Spoligotyping based on the polymorphism in the 36-bp direct-repeat locus was also performed. As a control, 43 M. tuberculosis isolates in 17 clusters obtained from patients in Arkansas during the study period were analyzed. Of the 25 interstate clusters, 19 were confirmed as correctly clustered when all the isolates were analyzed on the same gel using the IS6110-3' probe. Of the 19 true IS6110-3' clusters, 10 (53%) were subdivided by one or more secondary typing methods. Clustering of the control group was virtually identical by all methods. Of the three different secondary typing methods, spoligotyping was the least discriminating. IS6110-5' fingerprinting was as discriminating as PGRS fingerprinting. The data indicate that the IS6110-5' probe not only is a useful secondary typing method but also probably would prove to be a more useful primary typing method for a genotyping network which involves isolates from different geographic regions.

  5. Does Type of Child Risk Affect Whether Mothers Seek Assistance for Intimate Partner Violence From Civil or Criminal Court?

    Science.gov (United States)

    Palmer, Jane E; Renner, Lynette M; Goodman, Lisa A; Dutton, Mary Ann

    2016-03-01

    We examined whether risks to children of intimate partner violence survivors affected the type of legal assistance accessed. We hypothesized that the level and type of perceived child risk would be associated with whether women sought a protection order in civil court or filed charges against a current or former intimate partner in criminal court. Using data from a sample of predominantly African American women (N=293), we found that some forms of child risk were positively associated with seeking a civil order of protection but negatively associated with pressing criminal charges. Implications for practice, policy, and future research are presented. © The Author(s) 2015.

  6. 40 CFR 35.3525 - Authorized types of assistance from the Fund.

    Science.gov (United States)

    2010-07-01

    ... requirement in future years. (6) A State may provide incremental assistance for a project (e.g., for a... allowance from future capitalization grants. In addition, a State must: (i) Indicate in the Intended Use... State may buy or refinance local debt obligations of municipal, intermunicipal, or interstate agencies...

  7. Assistive acting movement therapy devices with pneumatic rotary-type soft actuators.

    Science.gov (United States)

    Wilkening, André; Baiden, David; Ivlev, Oleg

    2012-12-01

    Inherent compliance and assistive behavior are assumed to be essential properties for safe human-robot interaction. Rehabilitation robots demand the highest standards in this respect because the machine interacts directly with weak persons who are often sensitive to pain. Using novel soft fluidic actuators with rotary elastic chambers (REC actuators), compact, lightweight, and cost-effective therapeutic devices can be developed. This article describes modular design and control strategies for new assistive acting robotic devices for upper and lower extremities. Due to the inherent compliance and natural back-drivability of pneumatic REC actuators, these movement therapy devices provide gentle treatment, whereby the interaction forces between humans and the therapy device are estimated without the use of expensive force/torque sensors. An active model-based gravity compensation based on separated models of the robot and of the individual patient's extremity provides the basis for effective assistive control. The utilization of pneumatic actuators demands a special safety concept, which is merged with control algorithms to provide a sufficient level of safeness and to catch any possible system errors and/or emergency situations. A self-explanatory user interface allows for easy, intuitive handling. Prototypes are very comfortable for use due to several control routines that work in the background. Assistive devices have been tested extensively with several healthy persons; the knee/hip movement therapy device is now under clinical trials at the Clinic for Orthopaedics and Trauma Surgery at the Klinikum Stuttgart.

  8. Influence of solvent type on microwave-assisted liquefaction of bamboo

    Science.gov (United States)

    Jiulong Xie; Chung Hse; Todd F. Shupe; Tingxing Hu

    2016-01-01

    Microwave-assisted liquefaction of bamboo in glycerol, polyethylene glycerol (PEG), methanol, ethanol, and water were comparatively investigated by evaluating the temperature-dependence for conversion and liquefied residue characteristics. The conversion for the liquefaction in methanol, ethanol, and water increased with an increase in reaction temperature, while that...

  9. [Experience of Regional Vascular Centre in assisting patients with severe cerebrovascular accidents in Novosibirsk].

    Science.gov (United States)

    Doronin, B M; Marushak, A A; Popova, T F; Gribacheva, I A; Petrova, E V

    2016-01-01

    The analysis of the work of the neurological department of the Novosibirsk regional vascular center of City Clinical Hospital #1 for the period from 2013 to 2015 was done. We analyzed the annual reports of the regional vascular center, dynamics of cerebrovascular disease patterns, lethality, about the provision of medical care to patients with stroke, the use of high-tech methods of diagnosis and treatment. Ascertain the progress achieved and the perspectives of further improving the quality of care to patients with stroke due to wider use of methods of rehabilitation in the acute stage of stroke.

  10. Capsule Typing of Haemophilus influenzae by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry.

    Science.gov (United States)

    Månsson, Viktor; Gilsdorf, Janet R; Kahlmeter, Gunnar; Kilian, Mogens; Kroll, J Simon; Riesbeck, Kristian; Resman, Fredrik

    2018-03-01

    Encapsulated Haemophilus influenzae strains belong to type-specific genetic lineages. Reliable capsule typing requires PCR, but a more efficient method would be useful. We evaluated capsule typing by using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Isolates of all capsule types (a-f and nontypeable; n = 258) and isogenic capsule transformants (types a-d) were investigated. Principal component and biomarker analyses of mass spectra showed clustering, and mass peaks correlated with capsule type-specific genetic lineages. We used 31 selected isolates to construct a capsule typing database. Validation with the remaining isolates (n = 227) showed 100% sensitivity and 92.2% specificity for encapsulated strains (a-f; n = 61). Blinded validation of a supplemented database (n = 50) using clinical isolates (n = 126) showed 100% sensitivity and 100% specificity for encapsulated strains (b, e, and f; n = 28). MALDI-TOF mass spectrometry is an accurate method for capsule typing of H. influenzae.

  11. Types of educational assistance for students with disabilities or educational needs in Universidad Nacional de Costa Rica; its implications in their professional training

    Directory of Open Access Journals (Sweden)

    Angélica Fontana Hernández

    2017-01-01

    Full Text Available This article presents the types of educational assistance for students with disabilities or educational needs in the university environment and the implications for the students’ professional training, according to results obtained through the FIDA Project Percepciones y realidades en la atención de las necesidades educativas: propuesta de desarrollo profesional y su implementación en la Universidad Nacional (código 0524-10 del año 2012 al 2015 [Perceptions and realities in addressing educational needs: professional development proposal, and its implementation in the Universidad Nacional (code 0524-10 between 2012 and 2015]. One hundred and ninety-one students participated in this study (76 men and 115 women, which were enrolled in different careers in several UNA Branches (Central, Brunca, and Chorotega, as well as 427 staff members (181 men, and 246 women. The methodology uses a qualitative approach; 15 workshops and 65 individual interviews were conducted with students to gather their observations. It was found that only some of the students received individual assistance (during and outside classes, and occasionally tutoring (in English, Mathematics and Chemistry by academic staff of the institution in the Central Branch. For instance, more time is provided for them to take exams, during which they receive individual instructions; this is also done when they prepare research projects. One finding that stands out is that most students of UNA Regional Branches stated that their opinion is not taken into consideration by academic staff when determining and implementing adjustments in methodology or for evaluating the courses they receive. On the other hand, in the Central Branch, most members of the group of students with disabilities talk with academic staff about defining at least types of adjustment or educational assistance.

  12. CloudSat observations of cloud-type distribution over the Indian summer monsoon region

    Directory of Open Access Journals (Sweden)

    K. V. Subrahmanyam

    2013-07-01

    Full Text Available The three-dimensional distribution of various cloud types over the Indian summer monsoon (ISM region using five years (2006–2010 of CloudSat observations during June-July-August-September months is discussed for the first time. As the radiative properties, latent heat released and microphysical properties of clouds differ largely depending on the cloud type, it becomes important to know what types of clouds occur over which region. In this regard, the present analysis establishes the three-dimensional distribution of frequency of occurrence of stratus (St, stratocumulus (Sc, nimbostratus (Ns, cumulus (Cu, altocumulus (Ac, altostratus (As, cirrus (Ci and deep convective (DC clouds over the ISM region. The results show that the various cloud types preferentially occur over some regions of the ISM, which are consistent during all the years of observations. It is found that the DC clouds frequently occur over northeast of Bay of Bengal (BoB, Ci clouds over a wide region of south BoB–Indian peninsula–equatorial Indian Ocean, and Sc clouds over the north Arabian Sea. Ac clouds preferentially occur over land, and a large amount of As clouds are found over BoB. The occurrence of both St and Ns clouds over the study region is much lower than all other cloud types.The interannual variability of all these clouds including their vertical distribution is discussed. It is envisaged that the present study opens up possibilities to quantify the feedback of individual cloud type in the maintenance of the ISM through radiative forcing and latent heat release.

  13. Intra HLA-D/DR region recombinant detected by primed lymphocyte typing (PLT)

    DEFF Research Database (Denmark)

    Jakobsen, B K; Kristensen, T; Lamm, L U

    1983-01-01

    The chromosome 6 markers, HLA-ABC, D, DR, MT, properdin factor Bf, and complement factors 2 (C2) and 5 (C4), were studied in three families, each of which included two HLA identical siblings, one or both of whom were known to be HLA-B: GLO recombinants. The families were also typed with primed...... lymphocyte typing (PLT) for HLA-D/DR region associated DP antigens. None of these studies gave evidence that the recombinations had occurred within the HLA region. Mixed leucocyte culture (MLC) tests within the families showed no detectable stimulation between the HLA identical siblings in two...

  14. Microwave-assisted rapid synthesis of birnessite-type MnO{sub 2} nanoparticles for high performance supercapacitor applications

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Xiong; Miao, Wang; Li, Chen; Sun, Xianzhong; Wang, Kai; Ma, Yanwei, E-mail: ywma@mail.iee.ac.cn

    2015-11-15

    Highlights: • Birnessite-type MnO{sub 2} nanoparticles were prepared by the microwave-assisted reflux. • The microwave reaction duration was only 5 min. • A specific capacitance of 329 F g{sup −1} was obtained for birnessite-type MnO{sub 2}. - Abstract: Birnessite-type MnO{sub 2} nanoparticles have been successfully synthesized by the microwave-assisted reflux as short as 5 min. The microstructure and morphology of the products were characterized by X-ray diffraction, N{sub 2} adsorption–desorption isotherms, scanning electron microscopy, transmission electron microscopy. The electrochemical properties of the as-prepared MnO{sub 2} as an electrode material for supercapacitor were investigated by cyclic voltammetry and galvanostatic charge-discharge measurements in 1 M Na{sub 2}SO{sub 4} electrolyte, and a high specific capacitance of 329 F g{sup −1} was achieved at a current density of 0.2 A g{sup −1}. The specific capacitance retention was 92% after 1000 cycles at 2 A g{sup −1}, suggesting that it is a promising electrode material for supercapacitors.

  15. Therapeutic efficacy of narrow band imaging-assisted transurethral electrocoagulation for ulcer-type interstitial cystitis/painful bladder syndrome.

    Science.gov (United States)

    Kajiwara, Mitsuru; Inoue, Shougo; Kobayashi, Kanao; Ohara, Shinya; Teishima, Jun; Matsubara, Akio

    2014-04-01

    Narrow band imaging cystoscopy can increase the visualization and detection of Hunner's lesions. A single-center, prospective clinical trial was carried out aiming to show the effectiveness of narrow band imaging-assisted transurethral electrocoagulation for ulcer-type interstitial cystitis/painful bladder syndrome. A total of 23 patients (19 women and 4 men) diagnosed as having ulcer-type interstitial cystitis/painful bladder syndrome were included. All typical Hunner's lesions and suspected areas identified by narrow band imaging were electrocoagulated endoscopically after the biopsy of those lesions. Therapeutic efficacy was assessed prospectively by using visual analog scale score of pain, O'Leary-Sant's symptom index, O'Leary-Sant's problem index and overactive bladder symptom score. The mean follow-up period was 22 months. All patients (100%) experienced a substantial improvement in pain. The average visual analog scale pain scores significantly decreased from 7.3 preoperatively to 1.2 1 month postoperatively. A total of 21 patients (91.3%) who reported improvement had at least a 50% reduction in bladder pain, and five reported complete resolution. Daytime frequency was significantly decreased postoperatively. O'Leary-Sant's symptom index, O'Leary-Sant's problem index and overactive bladder symptom score were significantly decreased postoperatively. However, during the follow-up period, a total of six patients had recurrence, and repeat narrow band imaging-assisted transurethral electrocoagulation of the recurrent lesions was carried out for five of the six patients, with good response in relieving bladder pain. Our results showed that narrow band imaging-assisted transurethral electrocoagulation could be a valuable therapeutic alternative in patients with ulcer-type interstitial cystitis/painful bladder syndrome, with good efficacy and reduction of recurrence rate. © 2014 The Japanese Urological Association.

  16. Environmental barriers to participation and facilitators for use of three types of assistive technology devices.

    Science.gov (United States)

    Widehammar, Cathrine; Lidström, Helene; Hermansson, Liselotte

    2017-08-07

    The aim was to compare the presence of environmental barriers to participation and facilitators for assistive technology (AT) use and study the relation between barriers and AT use in three different AT devices. A cross-sectional survey was conducted. Inclusion criteria were ≥one year of experience as a user of myoelectric prosthesis (MEP), powered mobility device (PMD), or assistive technology for cognition (ATC) and age 20-90 years. Overall, 156 participants answered the Swedish version of the Craig Hospital Inventory of Environmental Factors and a study-specific questionnaire on facilitating factors. Non-parametric tests were used for comparisons. Barriers to participation were lowest in MEP users (md=0.12; p>0.001), and highest in ATC users (md=1.56; p>0.001) with the least support for AT use (p>0.001 - p=0.048). A positive correlation between fewer barriers and higher use of MEP was seen (r=0.30, p=0.038). The greatest barriers to participation were Natural environment, Surroundings and Information, and the most support came from relatives and professionals. Support, training and education are vital in the use of AT. These factors may lead to a more sustained and prolonged use of AT and may enable increased participation. Future research should focus on interventions that meet the needs of people with cognitive disabilities.

  17. Using Behavioral Interventions to Assist Children with Type 1 Diabetes Manage Blood Glucose Levels

    Science.gov (United States)

    Lasecki, Kim; Olympia, Daniel; Clark, Elaine; Jenson, William; Heathfield, Lora Tuesday

    2008-01-01

    Treatment and management of chronic disease processes on children occurs across multiple settings, placing demands for consultation and expertise on school personnel, including school psychologists. One such chronic condition in children is type I diabetes. Children with type I insulin dependent diabetes mellitus exhibit high rates of…

  18. Plexiform neurofibroma of the eye region occurring in patients without neurofibromatosis type 1

    DEFF Research Database (Denmark)

    Bechtold, Dorte; Hove, Hanne D; Prause, Jan Ulrik

    2012-01-01

    The purpose of the present study was to investigate the correlation between Plexiform Neurofibroma (PN) of the eye region and Neurofibromatosis type 1 (NF1). According to the textbooks of ophthalmology, PN and NF1 are very closely linked. Our clinical experience raised doubts about this, however....

  19. Aggregation Bias and Woman Abuse: Variations by Male Peer Support, Region, Language, and School Type.

    Science.gov (United States)

    Schwartz, Martin D.; DeKeseredy, Walter S.

    2000-01-01

    Analyzes the Canadian National Survey data on woman abuse to compare results for geographic regions, types of schools, and whether the students took the survey in French or English. None of these factors influenced the results. Male peer support measures did strongly affect male behavior in both physical and sexual abuse. (Author/JDM)

  20. Mitochondrial dysfunction in muscle tissue of complex regional pain syndrome type I patients

    NARCIS (Netherlands)

    Tan, E.C.T.H.; Janssen, A.J.W.M.; Roestenberg, P.M.H.; Heuvel, L.P.W.J. van den; Goris, R.J.A.; Rodenburg, R.J.T.

    2011-01-01

    Reactive oxygen species (ROS) are known to be involved in the pathophysiology of complex regional pain syndrome type I (CRPS I). Since the mitochondrial respiratory chain is a major source of ROS, we hypothesized that mitochondria play a role in the pathophysiology of CRPS I. The hypothesis was

  1. Mannitol as salvage treatment for Complex Regional Pain Syndrome Type I.

    NARCIS (Netherlands)

    Tan, E.C.T.H.; Tacken, M.C.; Groenewoud, J.M.M.; Goor, H. van; Frolke, J.P.M.

    2010-01-01

    INTRODUCTION: Complex Regional Pain Syndrome Type I (CRPS I) is a continuation of symptoms and signs due to a pathological exaggerated reaction in an extremity of the human body after an injury or operation. Although the clinical picture of CRPS I in the majority of patients is well known, the

  2. Evidence for local inflammation in complex regional pain syndrome type 1

    Directory of Open Access Journals (Sweden)

    Frank J. P. M. Huygen

    2002-01-01

    Full Text Available Background: The pathophysiology of complex regional pain syndrome type 1 (CRPS 1 is still a matter of debate. Peripheral afferent, efferent and central mechanisms are supposed. Based on clinical signs and symptoms (e.g. oedema, local temperature changes and chronic pain local inflammation is suspected.

  3. Informed Decision-Making Regarding Amputation for Complex Regional Pain Syndrome Type I

    NARCIS (Netherlands)

    Bodde, Marlies I.; Dijkstra, Pieter U.; Schrier, Michiel; van den Dungen, Johannes; den Dunnen, Wilfred E.; Geertzen, Joannes

    2014-01-01

    Background: Literature on complex regional pain syndrome type I (CRPS-I) discussing the decision to amputate or not, the level of amputation, or the timing of the amputation is scarce: We evaluated informed decision-making regarding amputation for CRPS-I. Methods: We describe our findings in a

  4. Job Satisfaction and Pay Satisfaction Levels of University Faculty by Discipline Type and by Geographic Region.

    Science.gov (United States)

    Terpstra, David E.; Honoree, Andre L.

    2004-01-01

    This study surveyed approximately 500 faculty across different disciplines from over 100 four- year colleges and universities in the U.S. The primary purpose of the study was to provide some empirical data on the general job satisfaction and pay satisfaction levels of faculty by type of academic discipline and by geographic region. The possible…

  5. Cerebral activation during motor imagery in complex regional pain syndrome type 1 with dystonia

    NARCIS (Netherlands)

    Gieteling, Esther W.; van Rijn, Monique A.; de Jong, Bauke M.; Hoogduin, Johannes M.; Renken, Remco; van Hilten, Jacobus J.; Leenders, Klaus L.

    The pathogenesis of dystonia in Complex Regional Pain Syndrome type 1 (CRPS-1) is unclear. In primary dystonia, functional magnetic resonance imaging (fMRI) has revealed changes in cerebral networks during execution of movement. The aim of this study was to determine cerebral network function in

  6. Size and type of places, geographical region, satisfaction with life, age, sex and place attachment

    Directory of Open Access Journals (Sweden)

    Mandal Alan

    2016-04-01

    Full Text Available The topic of the article concerns the issue of place attachment and its determinants. An analysis of place attachment was performed in terms of place identity and place dependence (Williams, Vaske, 2003. Moreover, links between place attachment and selected geographical (size and type of place, geographical region, demographic (age, sex and psychological (satisfaction with life variables were investigated.

  7. Stressful life events and psychological dysfunction in complex regional pain syndrome type I

    NARCIS (Netherlands)

    Geertzen, JHB; de Bruijn-Kofman, AT; de Bruijn, HP; van de Wiel, HBM; Dijkstra, PU

    Objective: To determine to what extent stressful life events and psychological dysfunction play a role in the pathogenesis of Complex Regional Pain Syndrome type I (CRPS). Design: A comparative study between a CRPS group and a control group. Stressful life events and psychological dysfunction

  8. Resilience in patients with amputation because of Complex Regional Pain Syndrome type I

    NARCIS (Netherlands)

    Bodde, Marlies I.; Schrier, Ernst; Krans, Hilde K.; Geertzen, J.H.B.; Dijkstra, Pieter U.

    2014-01-01

    Purpose: Although controversial, an amputation for longstanding and therapy-resistant Complex Regional Pain Syndrome Type I (CRPS-I) may improve quality of life and pain intensity. Resilience, the way people deal with adversity in a positive way may be related to these positive outcomes. This study

  9. Intra HLA-D/DR region recombinant detected by primed lymphocyte typing (PLT)

    DEFF Research Database (Denmark)

    Jakobsen, B K; Kristensen, T; Lamm, L U

    1983-01-01

    lymphocyte typing (PLT) for HLA-D/DR region associated DP antigens. None of these studies gave evidence that the recombinations had occurred within the HLA region. Mixed leucocyte culture (MLC) tests within the families showed no detectable stimulation between the HLA identical siblings in two......The chromosome 6 markers, HLA-ABC, D, DR, MT, properdin factor Bf, and complement factors 2 (C2) and 5 (C4), were studied in three families, each of which included two HLA identical siblings, one or both of whom were known to be HLA-B: GLO recombinants. The families were also typed with primed...... to reactive reagents. One of these (GHx), reacted with a determinant which segregated within the GG family as if child G was a paternal recombinant between the HLA-D, DR, DP, and C4 loci, on the one hand, and on the other hand one or more loci governing other HLA-D/DR region controlled lymphocyte activating...

  10. High-reliability microcontroller nerve stimulator for assistance in regional anaesthesia procedures.

    Science.gov (United States)

    Ferri, Carlos A; Quevedo, Antonio A F

    2017-07-01

    In the last decades, the use of nerve stimulators to aid in regional anaesthesia has been shown to benefit the patient since it allows a better location of the nerve plexus, leading to correct positioning of the needle through which the anaesthetic is applied. However, most of the nerve stimulators available in the market for this purpose do not have the minimum recommended features for a good stimulator, and this can lead to risks to the patient. Thus, this study aims to develop an equipment, using embedded electronics, which meets all the characteristics, for a successful blockade. The system is made of modules for generation and overall control of the current pulse and the patient and user interfaces. The results show that the designed system fits into required specifications for a good and reliable nerve stimulator. Linearity proved satisfactory, ensuring accuracy in electrical current amplitude for a wide range of body impedances. Field tests have proven very successful. The anaesthesiologist that used the system reported that, in all cases, plexus blocking was achieved with higher quality, faster anaesthetic diffusion and without needed of an additional dose when compared with same procedure without the use of the device.

  11. Novel type of peritoneocentesis trocar-assisted distal ventriculoperitoneal shunt placement with supervision via a one-port laparoscope.

    Science.gov (United States)

    Wang, Guangming; Yu, Jinlu; Luan, Yongxin; Han, Yanwu; Fu, Shuanglin

    2017-10-01

    Ventriculoperitoneal shunts (VPS) are the primary treatment for hydrocephalus and are associated with a high risk of complications, specifically in patients who are obese or have abdominal adhesions or shunt revisions. The present study describes the use of a novel type of peritoneal catheter peritoneocentesis trocar insertion with the assistance of a one-port laparoscope. A total of 36 patients with hydrocephalus underwent this novel type of peritoneocentesis trocar-assisted VPS. The distal shunt catheter was placed into the right subdiaphragmatic space and the catheter was traversed through a single hole drilled through the liver falciform ligament. The duration of the laparoscopic surgery ranged from 6-18 min (mean 10.4±1.6 min). No shunt-related infections or catheter malfunctions or injuries to the intra-abdominal organs occurred. The total abdominal incision length was 1.0 cm (0.5+0.5 cm). No laparoscopy-related complications were observed during follow-up assessments. The novel approach used in the current study is very easy to perform, and this method may significantly reduce the risk of malfunction complications. The presented method also has the advantages of reduced trauma and a simpler surgery. The current study indicated that this simple, minimally invasive procedure was beneficial for patients with hydrocephalus, specifically in cases of patients with obesity, peritoneal adhesions or shunt revisions.

  12. Evaluating for impact: what type of data can assist a health promoting school approach?

    Science.gov (United States)

    Joyce, Andrew; Dabrowski, Anna; Aston, Ruth; Carey, Gemma

    2017-04-01

    There is debate within the health promoting school (HPS) movement on whether schools should monitor health behaviour outcomes as part of an evaluation or rely more on process type measures, such as changes to school policies and the physical and social environment which yield information about (in)effective implementation. The debate is often framed around ideological considerations of the role of schools and there is little empirical work on how these indicators of effective implementation can influence change at a policy and practice level in real world settings. Information has potentially powerful effects in motivating a change process, but this will vary according to the type of information and the type of organizational culture into which it is presented. The current predominant model relies on process data, policy and environmental audit monitoring and benchmarking approaches, and there is little evidence of whether this engages school communities. Theoretical assertions on the importance of monitoring data to motivate change need to be empirically tested and, in doing so, we can learn which types of data influence adoption of HPS in which types of school and policy contexts. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  13. B- AND A-TYPE STARS IN THE TAURUS-AURIGA STAR-FORMING REGION

    International Nuclear Information System (INIS)

    Mooley, Kunal; Hillenbrand, Lynne; Rebull, Luisa; Padgett, Deborah; Knapp, Gillian

    2013-01-01

    We describe the results of a search for early-type stars associated with the Taurus-Auriga molecular cloud complex, a diffuse nearby star-forming region noted as lacking young stars of intermediate and high mass. We investigate several sets of possible O, B, and early A spectral class members. The first is a group of stars for which mid-infrared images show bright nebulae, all of which can be associated with stars of spectral-type B. The second group consists of early-type stars compiled from (1) literature listings in SIMBAD, (2) B stars with infrared excesses selected from the Spitzer Space Telescope survey of the Taurus cloud, (3) magnitude- and color-selected point sources from the Two Micron All Sky Survey, and (4) spectroscopically identified early-type stars from the Sloan Digital Sky Survey coverage of the Taurus region. We evaluated stars for membership in the Taurus-Auriga star formation region based on criteria involving: spectroscopic and parallactic distances, proper motions and radial velocities, and infrared excesses or line emission indicative of stellar youth. For selected objects, we also model the scattered and emitted radiation from reflection nebulosity and compare the results with the observed spectral energy distributions to further test the plausibility of physical association of the B stars with the Taurus cloud. This investigation newly identifies as probable Taurus members three B-type stars: HR 1445 (HD 28929), τ Tau (HD 29763), 72 Tau (HD 28149), and two A-type stars: HD 31305 and HD 26212, thus doubling the number of stars A5 or earlier associated with the Taurus clouds. Several additional early-type sources including HD 29659 and HD 283815 meet some, but not all, of the membership criteria and therefore are plausible, though not secure, members.

  14. A BMP responsive transcriptional region in the chicken type X collagen gene.

    Science.gov (United States)

    Volk, S W; Luvalle, P; Leask, T; Leboy, P S

    1998-10-01

    Bone morphogenetic proteins (BMPs) were originally identified by their ability to induce ectopic bone formation and have been shown to promote both chondrogenesis and chondrocyte hypertrophy. BMPs have recently been found to activate a membrane serine/threonine kinase signaling mechanism in a variety of cell types, but the downstream effectors of BMP signaling in chondrocyte differentiation remain unidentified. We have previously reported that BMP-2 markedly stimulates type X collagen expression in prehypertrophic chick sternal chondrocytes, and that type X collagen mRNA levels in chondrocytes cultured under serum-free (SF) conditions are elevated 3- to 5-fold within 24 h. To better define the molecular mechanisms of induction of chondrocyte hypertrophy by BMPs, we examined the effect of BMPs on type X collagen production by 15-day chick embryo sternal chondrocytes cultured under SF conditions in the presence or absence of 30 ng/ml BMP-2, BMP-4, or BMP-7. Two populations of chondrocytes were used: one representing resting cartilage isolated from the caudal third of the sterna and the second representing prehypertrophic cartilage from the cephalic third of the sterna. BMP-2, BMP-4, and BMP-7 all effectively promoted chondrocyte maturation of cephalic sternal chondrocytes as measured by high levels of alkaline phosphatase, diminished levels of type II collagen, and induction of the hypertrophic chondrocyte-specific marker, type X collagen. To test whether BMP control of type X collagen expression occurs at the transcriptional level, we utilized plasmid constructs containing the chicken collagen X promoter and 5' flanking regions fused to a reporter gene. Constructs were transiently transfected into sternal chondrocytes cultured under SF conditions in the presence or absence of 30 ng/ml BMP-2, BMP-4, or BMP-7. A 533 bp region located 2.4-2.9 kb upstream from the type X collagen transcriptional start site was both necessary and sufficient for strong BMP responsiveness

  15. Metallogenic characteristics of volcanic hydrothermal type U-Au-polymetallic deposits in Yanshan-Liaoning region

    International Nuclear Information System (INIS)

    Luo Yi; Zhou Dean; He Yiqiang; Tao Quan; Xia Yuliang; Cui Huanmin; Zhu Deling

    1996-03-01

    Yanshan-Liaoning area is located in the east part of the northern margin of North-China platform. It is a famous metallogenic region of Mesozoic volcanic hydrothermal type U-Au-polymetallic deposits in the country. The metallogenesis is controlled by a united Late Mesozoic continental taphrogenic volcano-magmatic activity. The metallogenic epochs are concentrated in Late Jurassic-Early Cretaceous periods. The metallogenic media are moderate and moderate-low temperature volcanic hydrothermal solutions originated from the mixing of volcano-magmatic water, metamorphic water and atmospheric water. The ore-forming materials are mainly derived from enrichment type upper mantle and lower crust. (8 refs., 5 figs.)

  16. Critical region of a type II superconducting film near Hsub(c2): rational approximants

    International Nuclear Information System (INIS)

    Ruggeri, G.J.

    1979-01-01

    The high-temperature perturbative expansions for the thermal quantities of a type II superconducting film are extrapolated to the critical region near Hsub(c2) by means of new rational approximants of the Pade type. The new approximants are forced to reproduce the leading correction to the flux lattice contribution on the low-temperature side of the transition. Compared to those previously considered in the literature: (i) the mutual consistency of the approximants is improved; and (ii) they are nearer to the exact solution of the zero-dimensional Landau-Ginsburg model. (author)

  17. Potential hippocampal region atrophy in diabetes mellitus type 2. A voxel-based morphometry VSRAD study

    International Nuclear Information System (INIS)

    Kamiyama, Kazutoshi; Sugihara, Masaki; Wada, Akihiko

    2010-01-01

    Among diabetes mellitus type 2 (DM2) patients, the frequency of cognitive dysfunction is higher and the relative risk of Alzheimer's disease (AD) is approximately twice that of nondiabetics. Cognitive impairment symptoms of AD are induced by limbic system dysfunction, and an early-stage AD brain without dementia has the potential for atrophy in the hippocampal region. In this study, we estimated potential hippocampal region atrophy in DM2 and pursued the association between DM2 and cognitive impairment/AD. Voxel-based morphometry analysis was performed in 28 diabetics (14 men, 14 women; ages 59-79 years, mean 70.7 years) and 28 sex- and age- matched (±1 year) nondiabetics. Severity of gray matter loss in the hippocampal region and whole brain were investigated. Group analysis was performed using two-tailed unpaired t-test; significance was assumed with less than 1% (P<0.01) of the critical rate. There was a significant difference between diabetics and nondiabetics regarding the severity of hippocampal region atrophy and whole-brain atrophy. Only diabetics showed a positive correlation for severity of hippocampal region atrophy and whole-brain atrophy (rs=0.69, P<0.0001). Aged DM2 patients have the potential for hippocampal region atrophy, and its dysfunction can be related to the expression of a cognitive impairment that resembles AD. (author)

  18. High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing.

    Directory of Open Access Journals (Sweden)

    Irene Tiemann-Boege

    2006-05-01

    Full Text Available For decades, classical crossover studies and linkage disequilibrium (LD analysis of genomic regions suggested that human meiotic crossovers may not be randomly distributed along chromosomes but are focused instead in "hot spots." Recent sperm typing studies provided data at very high resolution and accuracy that defined the physical limits of a number of hot spots. The data were also used to test whether patterns of LD can predict hot spot locations. These sperm typing studies focused on several small regions of the genome already known or suspected of containing a hot spot based on the presence of LD breakdown or previous experimental evidence of hot spot activity. Comparable data on target regions not specifically chosen using these two criteria is lacking but is needed to make an unbiased test of whether LD data alone can accurately predict active hot spots. We used sperm typing to estimate recombination in 17 almost contiguous ~5 kb intervals spanning 103 kb of human Chromosome 21. We found two intervals that contained new hot spots. The comparison of our data with recombination rates predicted by statistical analyses of LD showed that, overall, the two datasets corresponded well, except for one predicted hot spot that showed little crossing over. This study doubles the experimental data on recombination in men at the highest resolution and accuracy and supports the emerging genome-wide picture that recombination is localized in small regions separated by cold areas. Detailed study of one of the new hot spots revealed a sperm donor with a decrease in recombination intensity at the canonical recombination site but an increase in crossover activity nearby. This unique finding suggests that the position and intensity of hot spots may evolve by means of a concerted mechanism that maintains the overall recombination intensity in the region.

  19. A numerical method to enhance the performance of a cam-type electric motor-driven left ventricular assist device.

    Science.gov (United States)

    Huang, Huan; Yang, Ming; Lu, Cunyue; Xu, Liang; Zhuang, Xiaoqi; Meng, Fan

    2013-10-01

    Pulsatile left ventricular assist devices (LVADs) driven by electric motors have been widely accepted as a treatment of heart failure. Performance enhancement with computer assistance for this kind of LVAD has seldom been reported. In this article, a numerical method is proposed to assist the design of a cam-type pump. The method requires an integrated model of an LVAD system, consisting of a motor, a transmission mechanism, and a cardiovascular circulation. Performance indices, that is, outlet pressure, outlet flow, and pump efficiency, were used to select the best cam profile from six candidates. A prototype pump connected to a mock circulatory loop (MCL) was used to calibrate the friction coefficient of the cam groove and preliminarily evaluate modeling accuracy. In vitro experiments show that the mean outlet pressure and flow can be predicted with high accuracy by the model, and gross geometries of the measurements can also be reproduced. Simulation results demonstrate that as the total peripheral resistance (TPR) is fixed at 1.1 mm Hg.s/mL, the two-cycle 2/3-rise profile is the best. Compared with other profiles, the maximum increases of pressure and flow indices are 75 and 76%, respectively, and the maximum efficiency increase is over 51%. For different TPRs (0.5∼1.5 mm Hg.s/mL) and operation intervals (0.1∼0.4 s) in counterpulsation, the conclusion is also acceptable. © 2013 Wiley Periodicals, Inc. and International Center for Artificial Organs and Transplantation.

  20. [Development of a clinical pathway for the attention of patients with amyotrophic lateral sclerosis in a regional network. ALS Assistance Network-Comunidad de Madrid].

    Science.gov (United States)

    Rodríguez de Rivera, F J; Grande, M; García-Caballero, J; Muñoz-Blanco, J; Mora, J; Esteban, J; Guerrero, A; Matias-Guiu, J; de Andrés-Colsa, R; Buey, C; Díez-Tejedor, E

    2007-01-01

    Amyotrophic lateral sclerosis (ALS) requires complex multidisciplinary attention. Clinical pathways are assistance plans for certain diseases with a predictable course. These plans are established in isolated centers, not in multicenter regions. The aim is to develop a clinical pathway capable of organizing and homogenizing assistance given in ALS Assistance Network-Comunidad de Madrid which is made up of five hospitals, from the beginning until the end of the disease. In successive meetings, neurologists of these hospitals and members of the Madrid Health Service evaluated published therapeutic guidelines and other documents used in ALS assistance. A clinical pathway was developed adapting this information to social-health care conditions in the Comunidad de Madrid following the FOCUS-PDCA model. A clinical pathway was created consisting of a scientist-technical framework which arranges the attention in relationship to the diagnosis and treatment, according to the degree of disease progression and a chronogram. This is accompanied by several patient information documents on the disease and the tests that are required, and a patient assistance evaluation form. The standards are established to reach and to promote 354 constant improvement in patient care. Clinical pathway for the ALS assistance in a regional network organizes the attention and cares that the patients must receive from the beginning to the end of the disease. This arrangement and homogenization of the attention improves the quality of patient care, diminishes variability and rationalizes the use of the health care resources.

  1. Steam-assisted crystallization of TPA+-exchanged MCM-41 type mesoporous materials with thick pore walls

    International Nuclear Information System (INIS)

    Chen, Hong Li; Zhang, Kun; Wang, Yi Meng

    2012-01-01

    Highlights: ► Mesoporous Ti-containing silica with thicker pore walls was synthesized. ► Ion-exchange and steam-assisted crystallization led to MCM-41/MFI composite. ► The introduction of Ti inhibited the formation of separated MFI particles. ► Lower temperature favored retaining mesoporous characteristics and morphology. -- Abstract: Hierarchical MCM-41/MFI composites were synthesized through ion-exchange of as-made MCM-41 type mesoporous materials with tetrapropylammonium bromide and subsequent steam-assisted recrystallization. The obtained samples were characterized by powder X-ray diffraction (XRD), UV–vis diffuse reflectance spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis, FT-IR, 1 H– 13 C CP/MAS and nitrogen adsorption–desorption. The XRD patterns show that the MCM-41/MFI composite possesses both ordered MCM-41 phase and zeolite MFI phase. SEM and TEM images indicate that the recrystallized materials retained the mesoporous characteristics and the morphology of as-made mesoporous materials without the formation of bulky zeolite, quite different from the mechanical mixture of MCM-41 and MFI structured zeolite. Among others, lower recrystallization temperature and the introduction of the titanium to the parent materials are beneficial to preserve the mesoporous structure during the recrystallization process.

  2. Influence of chamber type integrated with computer-assisted semen analysis (CASA) system on the results of boar semen evaluation.

    Science.gov (United States)

    Gączarzewicz, D

    2015-01-01

    The objective of the study was to evaluate the effect of different types of chambers used in computer-assisted semen analysis (CASA) on boar sperm concentration and motility parameters. CASA measurements were performed on 45 ejaculates by comparing three commonly used chambers: Leja chamber (LJ), Makler chamber (MK) and microscopic slide-coverslip (SL). Concentration results obtained with CASA were verified by manual counting on a Bürker hemocytometer (BH). No significant differences were found between the concentrations determined with BH vs. LJ and SL, whereas higher (p0.05). The results obtained show that CASA assessment of boar semen should account for the effect of counting chamber on the results of sperm motility and concentration, which confirms the need for further study on standardizing the automatic analysis of boar semen.

  3. P-type doping of semipolar GaN(11 anti 22) by plasma-assisted molecular-beam epitaxy

    Energy Technology Data Exchange (ETDEWEB)

    Das, A.; Lahourcade, L. [Equipe Mixte CEA-CNRS, Nanophysique et Semiconducteurs, CEA-Grenoble, INAC/SP2M, Grenoble (France); Pernot, J. [Institut Neel, CNRS et Universite Joseph Fourier, Grenoble (France); Valdueza-Felip, S. [Equipe Mixte CEA-CNRS, Nanophysique et Semiconducteurs, CEA-Grenoble, INAC/SP2M, Grenoble (France); Dept. Electronica, Escuela Politecnica, Universidad de Alcala, Alcala de Henares, Madrid (Spain); Ruterana, P. [CIMAP, UMR6252, CNRS-ENSICAEN-CEA-UCBN, Caen (France); Laufer, A.; Eickhoff, M. [I. Physikalisches Institut, Justus-Liebig-Universitaet Giessen (Germany); Monroy, E.

    2010-07-15

    We report the effect of Mg doping on the growth kinetics of semipolar GaN(11-22) synthesized by plasma-assisted molecular-beam epitaxy. Mg tends to segregate on the surface, inhibiting the formation of the self-regulated Ga film which is used as a surfactant for the growth of undoped and Si-doped GaN(11-22). As a result, the growth widow is reduced for Mg doped layers, and we observe a certain deterioration of the surface morphology. In spite of this difficulties, homogenous Mg incorporation is achieved and layers display p -type conductivity for Mg atomic concentration higher than 7 x 10{sup 18} cm{sup -3}. Microscopy studies show no evidence of the pyramidal defects or polarity inversion domains found in Mg-doped GaN(0001). (copyright 2010 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  4. Tailor-made rehabilitation approach using multiple types of hybrid assistive limb robots for acute stroke patients: A pilot study.

    Science.gov (United States)

    Fukuda, Hiroyuki; Morishita, Takashi; Ogata, Toshiyasu; Saita, Kazuya; Hyakutake, Koichi; Watanabe, Junko; Shiota, Etsuji; Inoue, Tooru

    2016-01-01

    This article investigated the feasibility of a tailor-made neurorehabilitation approach using multiple types of hybrid assistive limb (HAL) robots for acute stroke patients. We investigated the clinical outcomes of patients who underwent rehabilitation using the HAL robots. The Brunnstrom stage, Barthel index (BI), and functional independence measure (FIM) were evaluated at baseline and when patients were transferred to a rehabilitation facility. Scores were compared between the multiple-robot rehabilitation and single-robot rehabilitation groups. Nine hemiplegic acute stroke patients (five men and four women; mean age 59.4 ± 12.5 years; four hemorrhagic stroke and five ischemic stroke) underwent rehabilitation using multiple types of HAL robots for 19.4 ± 12.5 days, and 14 patients (six men and eight women; mean age 63.2 ± 13.9 years; nine hemorrhagic stroke and five ischemic stroke) underwent rehabilitation using a single type of HAL robot for 14.9 ± 8.9 days. The multiple-robot rehabilitation group showed significantly better outcomes in the Brunnstrom stage of the upper extremity, BI, and FIM scores. To the best of the authors' knowledge, this is the first pilot study demonstrating the feasibility of rehabilitation using multiple exoskeleton robots. The tailor-made rehabilitation approach may be useful for the treatment of acute stroke.

  5. The Effect of Vacuum-Assisted Closure on the Bacterial Load and Type of Bacteria: A Systematic Review

    Science.gov (United States)

    Patmo, Aryan S.P.; Krijnen, Pieta; Tuinebreijer, Wim E.; Breederveld, Roelf S.

    2014-01-01

    Significance: A high bacterial load interferes with the healing process of a wound. Vacuum-assisted closure (VAC) is a wound healing therapy that utilizes a dressing system that continuously or intermittently applies a negative pressure to the wound surface. Recent Advances: VAC stimulates wound healing, but data on changes in the bacterial load and changes in the bacterial spectrum are scarce. Critical Issues: While VAC supposedly removes bacteria from the treated wounds and therefore reduces the risk of infection, this relationship has not yet been clinically proven. If VAC increases the bacterial load instead of decreasing it, then this may be a reason not to use VAC on certain types of wounds. Only seven small and heterogeneous studies reporting on the relationship between VAC usage and the bacterial load and type of bacteria in the treated wounds in clinical practice were found in the literature. Although there is some low quality evidence that VAC therapy does not change the bacterial load, no definite conclusions on changes in the bacterial load and type of bacteria during VAC can be drawn. Future Directions: Prospectively monitoring changes in the bacterial load and bacterial spectrum in patients that will receive VAC treatment on indication might be an effective way to find out whether it should indeed be used on specific wounds. PMID:24804158

  6. Microstructural analysis of the type-II boundary region in Alloy 152 weld

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Seung Chang; Choi, Kyoung Joon; Kim, Ji Hyun [Ulsan National Institute of Science and Technology, Ulsan (Korea, Republic of)

    2014-10-15

    The weld metals are more susceptible to SCC growth and that most cracks are blunted by the fusion boundary. However, they also found that some cracking occurs along the fusion boundary, often in an area with high hardness. Nelson et al. investigated a DMW of Monel 409 stainless steel and American Iron and Steel Institute (AISI) 1080 alloy and found a type-II boundary, which exists parallel to the fusion boundary in the dilution zone. They conclude that the type-II boundary is a potential path for crack growth. While there are several theories for the mechanisms of the type-II boundary formation, they conclude that the type-II boundary forms from the allotropic δ-γ transformation at the base metal in the elevated austenitic temperature range. As the operation time of nuclear power plants using DMWs of Alloy 152 and A533 Gr. B increases, these DMWs must be evaluated for their resistance to SCC for long-term operations. However, only few studies have investigated the thermal aging effects induced by long-term operations at high temperature. Type-II boundary is known as a potential crack path from the results of crack growth test at DMW without any heat treatment. So the analysis about type-II boundary with applying heat treatment could be helpful to evaluate the susceptibility to SCC of structural materials. The objective of this study is to analyze the detailed microstructure of the type-II boundary region in the DMW of Alloy 152 and A533 Gr. B, after applying heat treatment simulating thermal aging effect of a nuclear power plant operation condition to evaluate the susceptibility of this region to SCC. The microstructure of the type-II boundary region in the DMW of Alloy 152 and A533 Gr. B were analyzed with an energy dispersive x-ray spectroscope attached to a scanning electron microscope (SEM-EDS), electron backscatter diffraction (EBSD), and a nanoindentation test. Microstructural, grain boundary orientation, nanohardness analysis were conducted in the type

  7. Microstructural analysis of the type-II boundary region in Alloy 152 weld

    International Nuclear Information System (INIS)

    Yoo, Seung Chang; Choi, Kyoung Joon; Kim, Ji Hyun

    2014-01-01

    The weld metals are more susceptible to SCC growth and that most cracks are blunted by the fusion boundary. However, they also found that some cracking occurs along the fusion boundary, often in an area with high hardness. Nelson et al. investigated a DMW of Monel 409 stainless steel and American Iron and Steel Institute (AISI) 1080 alloy and found a type-II boundary, which exists parallel to the fusion boundary in the dilution zone. They conclude that the type-II boundary is a potential path for crack growth. While there are several theories for the mechanisms of the type-II boundary formation, they conclude that the type-II boundary forms from the allotropic δ-γ transformation at the base metal in the elevated austenitic temperature range. As the operation time of nuclear power plants using DMWs of Alloy 152 and A533 Gr. B increases, these DMWs must be evaluated for their resistance to SCC for long-term operations. However, only few studies have investigated the thermal aging effects induced by long-term operations at high temperature. Type-II boundary is known as a potential crack path from the results of crack growth test at DMW without any heat treatment. So the analysis about type-II boundary with applying heat treatment could be helpful to evaluate the susceptibility to SCC of structural materials. The objective of this study is to analyze the detailed microstructure of the type-II boundary region in the DMW of Alloy 152 and A533 Gr. B, after applying heat treatment simulating thermal aging effect of a nuclear power plant operation condition to evaluate the susceptibility of this region to SCC. The microstructure of the type-II boundary region in the DMW of Alloy 152 and A533 Gr. B were analyzed with an energy dispersive x-ray spectroscope attached to a scanning electron microscope (SEM-EDS), electron backscatter diffraction (EBSD), and a nanoindentation test. Microstructural, grain boundary orientation, nanohardness analysis were conducted in the type

  8. Bystander Intervention Prior to The Arrival of Emergency Medical Services: Comparing Assistance across Types of Medical Emergencies.

    Science.gov (United States)

    Faul, Mark; Aikman, Shelley N; Sasser, Scott M

    2016-01-01

    To determine the situational circumstances associated with bystander interventions to render aid during a medical emergency. This study examined 16.2 million Emergency Medical Service (EMS) events contained within the National Emergency Medical Services Information System. The records of patients following a 9-1-1 call for emergency medical assistance were analyzed using logistic regression to determine what factors influenced bystander interventions. The dependent variable of the model was whether or not a bystander intervened. EMS providers recorded bystander assistance 11% of the time. The logistic regression model correctly predicted bystander intervention occurrence 71.4% of the time. Bystanders were more likely to intervene when the patient was male (aOR = 1.12, 95% CI = 1.12-1.3) and if the patient was older (progressive aOR = 1.10, 1.46 age group 20-29 through age group 60-99). Bystanders were less likely to intervene in rural areas compared to urban areas (aOR = 0.58, 95% CI = 0.58-0.59). The highest likelihood of bystander intervention occurred in a residential institution (aOR = 1.86, 95% CI = 1.85-1.86) and the lowest occurred on a street or a highway (aOR = 0.96, 95% CI = 0.95-0.96). Using death as a reference group, bystanders were most likely to intervene when the patient had cardiac distress/chest pain (aOR = 11.38, 95% CI = 10.93-11.86), followed by allergic reaction (aOR = 7.63, 95% CI = 7.30-7.99), smoke inhalation (aOR = 6.65, 95% CI = 5.98-7.39), and respiration arrest/distress (aOR = 6.43, 95% CI = 6.17-6.70). A traumatic injury was the most commonly recorded known event, and it was also associated with a relatively high level of bystander intervention (aOR = 5.81, 95% CI = 5.58-6.05). The type of injury/illness that prompted the lowest likelihood of bystander assistance was Sexual Assault/Rape (aOR = 1.57, 95% CI = 1.32-1.84) followed by behavioral/psychiatric disorder (aOR = 1.64, 95% CI = 1.57-1.71). Bystander intervention varies greatly on

  9. Three-dimensional evaluation of soft tissue changes in the orofacial region after tooth-borne and bone-borne surgically assisted rapid maxillary expansion

    NARCIS (Netherlands)

    Nada, R.M.; Loon, B. van; Maal, T.J.J.; Berge, S.J.; Mostafa, Y.A.; Kuijpers-Jagtman, A.M.; Schols, J.G.J.H.

    2013-01-01

    OBJECTIVES: This study seeks to three-dimensionally assess soft tissue changes in the orofacial region following tooth-borne and bone-borne surgically assisted rapid maxillary expansion (SARME). MATERIALS AND METHODS: This prospective cohort study included 40 skeletally mature patients with

  10. Relationships of mercury concentrations across tissue types, muscle regions and fins for two shark species

    KAUST Repository

    O'Bryhim, Jason R.

    2017-01-31

    Mercury (Hg) exposure poses a threat to both fish and human health. Sharks are known to bioaccumulate Hg, however, little is known regarding how Hg is distributed between different tissue groups (e.g. muscle regions, organs). Here we evaluated total mercury (THg) concentrations from eight muscle regions, four fins (first dorsal, left and right pectorals, caudal-from both the inner core and trailing margin of each fin), and five internal organs (liver, kidney, spleen, heart, epigonal organ) from two different shark species, bonnethead (Sphyrna tiburo) and silky shark (Carcharhinus falciformis) to determine the relationships of THg concentrations between and within tissue groups. Total Hg concentrations were highest in the eight muscle regions with no significant differences in THg concentrations between the different muscle regions and muscle types (red and white). Results from tissue collected from any muscle region would be representative of all muscle sample locations. Total Hg concentrations were lowest in samples taken from the fin inner core of the first dorsal, pectoral, and caudal (lower lobe) fins. Mercury concentrations for samples taken from the trailing margin of the dorsal, pectoral, and caudal fins (upper and lower lobe) were also not significantly different from each other for both species. Significant relationships were found between THg concentrations in dorsal axial muscle tissue and the fin inner core, liver, kidney, spleen and heart for both species as well as the THg concentrations between the dorsal fin trailing margin and the heart for the silky shark and all other sampled tissue types for the bonnethead shark. Our results suggest that biopsy sampling of dorsal muscle can provide data that can effectively estimate THg concentrations in specific organs without using more invasive, or lethal methods.

  11. A computer-assisted rock type data catalogue for gas formations; Ein rechnergestuetzter Gesteinsdatenkatalog fuer Gasformationen

    Energy Technology Data Exchange (ETDEWEB)

    Reitenbach, V.; Pusch, G.; Moeller, M.; Koll, S. [TU Clausthal (Germany). Inst. fuer Erdoel- und Erdgastechnik; Constantini, A.; Junker, A.; Anton, H. [RWE Dea AG, Hamburg (Germany)

    2007-09-13

    Modern reservoir management commonly requires versatile reservoir data which are neces-sary for integrated reservoir characterization, evaluation and development planning. The rock data necessary for numerical reservoir simulation studies often have to be collected from different sources, analysed and sorted with a considerable effort. In a framework of DGMK research program (DGMK project 593-9/4), the Institute of Petro-leum Engineering (Clausthal University of Technology) and RWE DEA AG have developed a new tool named Rock Data Catalogue, which is capable of managing large amounts of rock data more efficiently and deriving new specific correlations for European rock types. The use of Rock Data Catalogue can facilitate the essential input data generation and proc-essing procedure for reservoir simulation studies. The Rock Data Catalogue is comprised of a Data Base Module of digitalized reservoir rock data and an interactive Data Correlation Module. Both modules are built-up as an interface to common reservoir simulation software. The universal structure of the software also makes it possible to exchange the data with other rock data information systems. The Data Correlation Module implements a ''Decision-Structure'' module, which helps the reservoir engineer to select the rock data for analysis and correlation depending on its litho-facial type and permeability class. The Data Base Module enables a quick search of appro-priated data sets and their export into the correlation module. The open source data of the North German Rotliegend gas formations as well as the data of measurements on Rotliegend core samples performed at the ITE in course of the DGMK tight gas projects were implemented in the rock data base. Correlations of poro/perm data, two-phase flow and capillary pressure functions of the Rotliegend sandstones with the per-meability range between 20 and 0.01 mD are implemented in the rock data base and serve for quality checking of the

  12. Anxiety type modulates immediate versus delayed engagement of attention-related brain regions.

    Science.gov (United States)

    Spielberg, Jeffrey M; De Leon, Angeline A; Bredemeier, Keith; Heller, Wendy; Engels, Anna S; Warren, Stacie L; Crocker, Laura D; Sutton, Bradley P; Miller, Gregory A

    2013-09-01

    Background Habituation of the fear response, critical for the treatment of anxiety, is inconsistently observed during exposure to threatening stimuli. One potential explanation for this inconsistency is differential attentional engagement with negatively valenced stimuli as a function of anxiety type. Methods The present study tested this hypothesis by examining patterns of neural habituation associated with anxious arousal, characterized by panic symptoms and immediate engagement with negatively valenced stimuli, versus anxious apprehension, characterized by engagement in worry to distract from negatively valenced stimuli. Results As predicted, the two anxiety types evidenced distinct patterns of attentional engagement. Anxious arousal was associated with immediate activation in attention-related brain regions that habituated over time, whereas anxious apprehension was associated with delayed activation in attention-related brain regions that occurred only after habituation in a worry-related brain region. Conclusions Results further elucidate mechanisms involved in attention to negatively valenced stimuli and indicate that anxiety is a heterogeneous construct with regard to attention to such stimuli.

  13. Geology and potential of the formation of sandstone type uranium mineralization at Hatapang region, North Sumatera

    International Nuclear Information System (INIS)

    Ngadenin

    2013-01-01

    The Study based on geological setting of Hatapang region, North Sumatera, identified as a favourable area to the formation of sandstone type uranium mineralization. This characterized by the occurred of anomalous radioactivity, uranium contents of the upper cretaceous granite intrusions and radioactivity anomalous of tertiary sedimentary rocks deposited in terrestrial environments. The study is objective to find out the potential formation of sandstone type-uranium mineralization within tertiary sedimentary rocks based on data’s studies of geological, geochemical, mineralogy, radioactivity of rocks. Stratigraphy of Hatapang area of the oldest to youngest are quartz units (permian-carboniferous), sandstone units (upper Triassic), granite (upper cretaceous), conglomerate units (Lower –middle Miocene) and tuff units (Pleistocene). Hatapang’s granite is S type granite which is not only potential as source of radioactive minerals, particularly placer type monazite, but also potential as source rocks of sandstone type-uranium mineralization on lighter sedimentary rocks. Sedimentary rock of conglomerate units has potential as host rock, even though uranium did not accumulated in its rocks since the lack number of carbon as precipitant material and dissolved U"+"6 in water did not reduced into U"+"4 caused the uranium mineralization did not deposited. (author)

  14. Teachers' attitudes and perceptions about preparation of public schools to assist students with type 1 diabetes.

    Science.gov (United States)

    Carral San Laureano, Florentino; Gutiérrez Manzanedo, José Vicente; Moreno Vides, Pablo; de Castro Maqueda, Guillermo; Fernández Santos, Jorge R; Ponce González, Jesús Gustavo; Ayala Ortega, María Del Carmen

    2018-04-01

    To assess teachers' attitudes and perceptions about preparation of public primary and secondary education schools in the Puerto Real University Hospital (Cádiz, Spain) area to care for students with type 1 diabetes mellitus (T1DM) METHODS: A descriptive observational study where answers to an attitude and perception questionnaire on the preparation of schools to care for pupils with T1DM were analyzed. A total of 765 teachers (mean age, 44.3±8.8 years; 61.7% women) from 44 public schools in the area of the Puerto Real University Hospital were selected by random sampling. Overall, 43.2% of teachers surveyed had or had previously had students with T1DM, but only 0.8% had received specific training on diabetes. 18.9% of teachers reported that one of their students with T1DM had experienced at least one episode of hypoglycemia at school, and half of them felt that their school was not prepared to deal with diabetic emergencies. 6.4% stated that their school had glucagon in its first aid kit, and 46.9% would be willing to administer it personally. Women, physical education teachers, and headmasters had a more positive perception of the school than their colleagues. Teachers with a positive perception of school preparation and with a positive attitude to administer glucagon were significantly younger than those with no positive perception and attitude. The study results suggest that teachers of public schools in our health area have not been specifically trained in the care of patients with T1DM and perceive that their educational centers are not qualified to address diabetic emergencies. Copyright © 2017 SEEN y SED. Publicado por Elsevier España, S.L.U. All rights reserved.

  15. Retrospective study of histological types of esophageal cancer prevalent in the Metropolitan Region of Santiago, Chile

    Directory of Open Access Journals (Sweden)

    Andrés Torrealba Bustos

    2010-11-01

    Full Text Available This study tries to determine the statistical relation between the most frequent histological types of oesophageal carcinoma in the Metropolitan region of Santiago, Chile. For it there were obtained clinical samples of different laboratories of Pathological Anatomy of the Metropolitan region corresponding to the south and east sector of Santiago, gathering a total of 348 cases, which were diagnosed by means of endoscopic biopsy, using as parameters the morphologic characteristics of neoplastic tissue evaluated by light microscopy with hematoxylin-eosin dye. The obtained information was submitted to a model of logistic multiple regression, in order to determine the associations between the most frequent histological types of oesophageal cancer (adenocarcinoma and squamous carcinoma, topographic location compromised to the moment of the diagnosis, age and sex of the patients in study. The proportion between the histological types of cancer of esophagus did not present significant differences, which contrasts with the results of international publications. The analyses demonstrated that the low third is the only parameter that is subject to variation, which relates to the metaplasia of Barrett and the development of oesophageal adenocarcinoma.

  16. Prevalence and characteristics of various types of lichen planus in the Moscow Region

    Directory of Open Access Journals (Sweden)

    Yu. V. Molochkova

    2018-01-01

    Full Text Available Rationale: Lichen planus (LP is an important problem for the healthcare due to its increasing prevalence, as well as typical, atypical and prone to malignization types of the disease that can be both severe and poorly responding to treatment. Accurate data on the prevalence of LP are lacking.Aim: To assess the prevalence of various LP types in the patient population of the Moscow Region.Materials and methods: We analyzed the results of examination of 338 patients with LP, who were getting standard treatment in the Department of Dermatovenereology and Dermato-oncology of the Moscow Regional Research and Clinical Institute (MONIKI in 1999 to 2017.Results: Among 338 LP patients, atypical LP of the skin was diagnosed in 81 (23.96%: hypertrophic type, in 31 (38.27%, pigmented, in 23 (28.4%, atrophic, in 11 (13.58%, follicular, in 8 (9.88%, lichen obtusus, in 3 (3.7%, bullous, in 1 (1.23%, erythematous, in 1 (1.23%, vulvovaginal-gingival syndrome, in 2 (2.47%, and Grinspan's syndrome, in 1 (1.23%. In 35 (43.21% of patients, cutaneous LP was associated with atypical oral LP (OLP: in 17 (48.57% of cases with hyperkeratotic, in 11 (31.43%, with erosive, and in 7 (20%, with exudative-hyperemic type. In 19 (23.46% cases, atypical cutaneous LP was associated with LP of the genital mucosae, including in 12 (63.16% cases with a typical reticular type, in 6 (31.58%, with atypical erosive, and in 1 (5.26%, with hypertrophic type. In 16 (4.73% of the patients there was atypical OLP only; in 6 (37.5% of them it had the exudative-hyperemic type, in 5 (31.25%, erosive, and in 5 (31.25%, hyperkeratotic. The most severe course of the dermatosis was observed for follicular, atrophic, hypertrophic types of cutaneous LP, vulvovaginal-gingival syndrome, and erosive OLP.Conclusion: Atypical LP was diagnosed in 81 (23.96% cases, and in 45 (55.6% cases it was associated with the OLP. The latter in 35 (43.21% of cases was characterized by atypical lesions of OLP, including

  17. Comparison of regional index flood estimation procedures based on the extreme value type I distribution

    DEFF Research Database (Denmark)

    Kjeldsen, Thomas Rodding; Rosbjerg, Dan

    2002-01-01

    the prediction uncertainty and that the presence of intersite correlation tends to increase the uncertainty. A simulation study revealed that in regional index-flood estimation the method of probability weighted moments is preferable to method of moment estimation with regard to bias and RMSE.......A comparison of different methods for estimating T-year events is presented, all based on the Extreme Value Type I distribution. Series of annual maximum flood from ten gauging stations at the New Zealand South island have been used. Different methods of predicting the 100-year event...... and the connected uncertainty have been applied: At-site estimation and regional index-flood estimation with and without accounting for intersite correlation using either the method of moments or the method of probability weighted moments for parameter estimation. Furthermore, estimation at ungauged sites were...

  18. Substrate type < 111 >-Cu{sub 2}O/<0001 >-ZnO photovoltaic device prepared by photo-assisted electrodeposition

    Energy Technology Data Exchange (ETDEWEB)

    Zamzuri, Mohd, E-mail: zamzuri@tf.me.tut.ac.jp [Department of Mechanical Eng., Toyohashi University of Technology, 1-1 Hibari Gaoka, Tempaku, Toyohashi, Aichi 441-8580 (Japan); School of Manufacturing Eng., Universiti Malaysia Perlis, Kampus Tetap Pauh Putra, Jln Arau-Changlun, 02600 Arau, Perlis (Malaysia); Sasano, Junji [Department of Mechanical Eng., Toyohashi University of Technology, 1-1 Hibari Gaoka, Tempaku, Toyohashi, Aichi 441-8580 (Japan); Mohamad, Fariza Binti [Faculty of Electrical & Electronic Eng., University Tun Hussein Onn Malaysia, 86400, Parit Raja, Batu Pahat, Johor (Malaysia); Izaki, Masanobu [Department of Mechanical Eng., Toyohashi University of Technology, 1-1 Hibari Gaoka, Tempaku, Toyohashi, Aichi 441-8580 (Japan)

    2015-11-30

    The substrate-type < 0001 > ZnO/<111 > Cu{sub 2}O photovoltaic (PV) device has been constructed by electrodeposition of a < 111 >-p-Cu{sub 2}O layer on an Au(111)/Si wafer substrate followed by stacking the n-ZnO layer by electrodeposition during light irradiation in aqueous solutions. The PV device was fabricated by stacking the Al:ZnO-window by sputtering and the top Al electrode by vacuum evaporation. The < 0001 >-ZnO layer was composed of aggregates of hexagonal columnar grains grown in the direction normal to the surface, and pores could be observed between the ZnO grains at the deposition time last 1800 s. The < 0001 >-ZnO/<111 >-Cu{sub 2}O PV device showed a photovoltaic performance under AM1.5 illumination, and showed the improved short-circuit current density of 5.87 mA cm{sup −2} by stacking the AZO-TCO due to the increase in the diffusion length of the carrier. - Highlights: • Substrate type ZnO/Cu{sub 2}O photovoltaic devices only by electrodeposition • ZnO layer was stacked on the Cu{sub 2}O layer by photo-assisted electrodeposition. • AZO/ZnO/Cu{sub 2}O photovoltaic devices with a short-circuit current density of 5.87 mA cm{sup −2}.

  19. Spatial Variation of Soil Type and Soil Moisture in the Regional Atmospheric Modeling System

    Energy Technology Data Exchange (ETDEWEB)

    Buckley, R.

    2001-06-27

    Soil characteristics (texture and moisture) are typically assumed to be initially constant when performing simulations with the Regional Atmospheric Modeling System (RAMS). Soil texture is spatially homogeneous and time-independent, while soil moisture is often spatially homogeneous initially, but time-dependent. This report discusses the conversion of a global data set of Food and Agriculture Organization (FAO) soil types to RAMS soil texture and the subsequent modifications required in RAMS to ingest this information. Spatial variations in initial soil moisture obtained from the National Center for Environmental Predictions (NCEP) large-scale models are also introduced. Comparisons involving simulations over the southeastern United States for two different time periods, one during warmer, more humid summer conditions, and one during cooler, dryer winter conditions, reveals differences in surface conditions related to increases or decreases in near-surface atmospheric moisture con tent as a result of different soil properties. Three separate simulation types were considered. The base case assumed spatially homogeneous soil texture and initial soil moisture. The second case assumed variable soil texture and constant initial soil moisture, while the third case allowed for both variable soil texture and initial soil moisture. The simulation domain was further divided into four geographically distinct regions. It is concluded there is a more dramatic impact on thermodynamic variables (surface temperature and dewpoint) than on surface winds, and a more pronounced variability in results during the summer period. While no obvious trends in surface winds or dewpoint temperature were found relative to observations covering all regions and times, improvement in surface temperatures in most regions and time periods was generally seen with the incorporation of variable soil texture and initial soil moisture.

  20. Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number

    DEFF Research Database (Denmark)

    Mau Kai, C; Juul, A; McElreavey, K

    2008-01-01

    number, supplemented with haplogroup typing in deleted patients, were performed, in combination with clinical assessments in 264 fathers and their sons conceived by assisted reproduction techniques (ART), and in 168 fertile men with normal sperm concentration. RESULTS: In the ART fathers group...

  1. Service experience with AISI type 316 steel components in CEGB Midlands Region power plant

    International Nuclear Information System (INIS)

    Plastow, B.; Bagnall, B.I.; Yeldham, D.E.

    1979-01-01

    The service performance of AISI Type 316 steel components in sections up to 100 mm thick in Power Plant of the Midlands Region of the C.E.G.B. is reviewed. A comparison is drawn between the satisfactory performance of components whose dimensional stability is not critical and the difficulties experienced when rapid rates of change of temperature cause distortion in thick section components. Weldment manufacture and performance are reviewed and both are considered to be satisfactory. In general the material has performed well and the difficulties due to distortion have been overcome by imposing operating regimes which limit rates of temperature change. (author)

  2. Complex regional pain syndrome type 1 mimicking Raynaud’s phenomenon

    Directory of Open Access Journals (Sweden)

    Serpil Tuna

    2014-09-01

    Full Text Available Complex regional pain syndrome type 1 (CRPS-1 is a chronic pain syndrome characterized by severe pain, swelling, autonomic dysfunction and dystrophic changes in affected extremity. RSDS is a rare disease in children and usually occurs after trauma, however, without trauma may also occur. We were detected CRPS-1 activated by cold and stress and characterized by recurrent attacks in the bilateral upper extremities in 14 year-old girl, which is similar to Raynaud’s phenomenon. We present this case with the literature because of its rarity and atypical course.

  3. Region and cell-type resolved quantitative proteomic map of the human heart

    DEFF Research Database (Denmark)

    Doll, Sophia; Dreßen, Martina; Geyer, Philipp E

    2017-01-01

    The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge of the identity and quantity of its constituent proteins is still lacking. Here, we determine the healthy human heart proteome by measuring 16 anatomical regions and three major...... cardiac cell types by high-resolution mass spectrometry-based proteomics. From low microgram sample amounts, we quantify over 10,700 proteins in this high dynamic range tissue. We combine copy numbers per cell with protein organellar assignments to build a model of the heart proteome at the subcellular...

  4. Influences of Duration of Inspiratory Effort, Respiratory Mechanics, and Ventilator Type on Asynchrony With Pressure Support and Proportional Assist Ventilation.

    Science.gov (United States)

    Vasconcelos, Renata S; Sales, Raquel P; Melo, Luíz H de P; Marinho, Liégina S; Bastos, Vasco Pd; Nogueira, Andréa da Nc; Ferreira, Juliana C; Holanda, Marcelo A

    2017-05-01

    Pressure support ventilation (PSV) is often associated with patient-ventilator asynchrony. Proportional assist ventilation (PAV) offers inspiratory assistance proportional to patient effort, minimizing patient-ventilator asynchrony. The objective of this study was to evaluate the influence of respiratory mechanics and patient effort on patient-ventilator asynchrony during PSV and PAV plus (PAV+). We used a mechanical lung simulator and studied 3 respiratory mechanics profiles (normal, obstructive, and restrictive), with variations in the duration of inspiratory effort: 0.5, 1.0, 1.5, and 2.0 s. The Auto-Trak system was studied in ventilators when available. Outcome measures included inspiratory trigger delay, expiratory trigger asynchrony, and tidal volume (V T ). Inspiratory trigger delay was greater in the obstructive respiratory mechanics profile and greatest with a effort of 2.0 s (160 ms); cycling asynchrony, particularly delayed cycling, was common in the obstructive profile, whereas the restrictive profile was associated with premature cycling. In comparison with PSV, PAV+ improved patient-ventilator synchrony, with a shorter triggering delay (28 ms vs 116 ms) and no cycling asynchrony in the restrictive profile. V T was lower with PAV+ than with PSV (630 mL vs 837 mL), as it was with the single-limb circuit ventilator (570 mL vs 837 mL). PAV+ mode was associated with longer cycling delays than were the other ventilation modes, especially for the obstructive profile and higher effort values. Auto-Trak eliminated automatic triggering. Mechanical ventilation asynchrony was influenced by effort, respiratory mechanics, ventilator type, and ventilation mode. In PSV mode, delayed cycling was associated with shorter effort in obstructive respiratory mechanics profiles, whereas premature cycling was more common with longer effort and a restrictive profile. PAV+ prevented premature cycling but not delayed cycling, especially in obstructive respiratory mechanics

  5. Chlamydia trachomatis Strain Types Have Diversified Regionally and Globally with Evidence for Recombination across Geographic Divides

    Directory of Open Access Journals (Sweden)

    Vitaly Smelov

    2017-11-01

    Full Text Available Chlamydia trachomatis (Ct is the leading cause of bacterial sexually transmitted diseases worldwide. The Ct Multi Locus Sequence Typing (MLST scheme is effective in differentiating strain types (ST, deciphering transmission patterns and treatment failure, and identifying recombinant strains. Here, we analyzed 323 reference and clinical samples, including 58 samples from Russia, an area that has not previously been represented in Ct typing schemes, to expand our knowledge of the global diversification of Ct STs. The 323 samples resolved into 84 unique STs, a 3.23 higher typing resolution compared to the gold standard single locus ompA genotyping. Our MLST scheme showed a high discriminatory index, D, of 0.98 (95% CI 0.97–0.99 confirming the validity of this method for typing. Phylogenetic analyses revealed distinct branches for the phenotypic diseases of lymphogranuloma venereum, urethritis and cervicitis, and a sub-branch for ocular trachoma. Consistent with these findings, single nucleotide polymorphisms were identified that significantly correlated with each phenotype. While the overall number of unique STs per region was comparable across geographies, the number of STs was greater for Russia with a significantly higher ST/sample ratio of 0.45 (95% CI: 0.35–0.53 compared to Europe or the Americas (p < 0.009, which may reflect a higher level of sexual mixing with the introduction of STs from other regions and/or reassortment of alleles. Four STs were found to be significantly associated with a particular geographic region. ST23 [p = 0.032 (95% CI: 1–23], ST34 [p = 0.019 (95% CI: 1.1–25]; and ST19 [p = 0.001 (95% CI: 1.7–34.7] were significantly associated with Netherlands compared to Russia or the Americas, while ST 30 [p = 0.031 (95% CI: 1.1–17.8] was significantly associated with the Americas. ST19 was significantly associated with Netherlands and Russia compared with the Americans [p = 0.001 (95% CI: 1.7–34.7 and p = 0.006 (95

  6. An integrated tool to study MHC region: accurate SNV detection and HLA genes typing in human MHC region using targeted high-throughput sequencing.

    Directory of Open Access Journals (Sweden)

    Hongzhi Cao

    Full Text Available The major histocompatibility complex (MHC is one of the most variable and gene-dense regions of the human genome. Most studies of the MHC, and associated regions, focus on minor variants and HLA typing, many of which have been demonstrated to be associated with human disease susceptibility and metabolic pathways. However, the detection of variants in the MHC region, and diagnostic HLA typing, still lacks a coherent, standardized, cost effective and high coverage protocol of clinical quality and reliability. In this paper, we presented such a method for the accurate detection of minor variants and HLA types in the human MHC region, using high-throughput, high-coverage sequencing of target regions. A probe set was designed to template upon the 8 annotated human MHC haplotypes, and to encompass the 5 megabases (Mb of the extended MHC region. We deployed our probes upon three, genetically diverse human samples for probe set evaluation, and sequencing data show that ∼97% of the MHC region, and over 99% of the genes in MHC region, are covered with sufficient depth and good evenness. 98% of genotypes called by this capture sequencing prove consistent with established HapMap genotypes. We have concurrently developed a one-step pipeline for calling any HLA type referenced in the IMGT/HLA database from this target capture sequencing data, which shows over 96% typing accuracy when deployed at 4 digital resolution. This cost-effective and highly accurate approach for variant detection and HLA typing in the MHC region may lend further insight into immune-mediated diseases studies, and may find clinical utility in transplantation medicine research. This one-step pipeline is released for general evaluation and use by the scientific community.

  7. Prevalence of Brick Tea-Type Fluorosis in the Tibet Autonomous Region.

    Science.gov (United States)

    Fan, Zhipeng; Gao, Yanhui; Wang, Wei; Gong, Hongqiang; Guo, Min; Zhao, Shengcheng; Liu, Xuehui; Yu, Bing; Sun, Dianjun

    2016-01-01

    The prevalence of brick tea-type fluorosis is high in Tibet because of the habit of drinking brick tea in this region. Brick tea-type fluorosis has become an urgent public health problem in China. A cross-sectional survey was conducted to investigate prevalence of brick tea-type fluorosis in all districts of Tibet using a stratified cluster sampling method. Dental fluorosis in children aged 8-12 years and clinical skeletal fluorosis in adults were diagnosed according to the national criteria. A total of 423 children and 1320 adults participated in the study. Samples of drinking water, brick tea, brick tea infusion (or buttered tea), and urine were collected and measured for fluoride concentrations by the fluoride ion selective electrode method. The fluoride level in all but one of the brick tea samples was above the national standard. The average daily fluoride intake from drinking brick tea in all seven districts in Tibet was much higher than the national standard. The prevalence of dental fluorosis was 33.57%, and the prevalence of clinical skeletal fluorosis was 46.06%. The average daily fluoride intake from drinking brick tea (r = 0.292, P < 0.05), urine fluoride concentrations in children (r = 0.134, P < 0.05), urine fluoride concentrations in adults (r = 0.162, P < 0.05), and altitude (r = 0.276, P < 0.05) were positively correlated with the prevalence of brick tea-type fluorosis. Herdsmen had the highest fluoride exposure and the most severe skeletal fluorosis. Brick tea-type fluorosis in Tibet is more serious than in other parts of China. The altitude and occupational factors are important risk factors for brick tea-type fluorosis.

  8. Prevalence of Brick Tea-Type Fluorosis in the Tibet Autonomous Region

    Directory of Open Access Journals (Sweden)

    Zhipeng Fan

    2016-02-01

    Full Text Available Background: The prevalence of brick tea-type fluorosis is high in Tibet because of the habit of drinking brick tea in this region. Brick tea-type fluorosis has become an urgent public health problem in China. Methods: A cross-sectional survey was conducted to investigate prevalence of brick tea-type fluorosis in all districts of Tibet using a stratified cluster sampling method. Dental fluorosis in children aged 8–12 years and clinical skeletal fluorosis in adults were diagnosed according to the national criteria. A total of 423 children and 1320 adults participated in the study. Samples of drinking water, brick tea, brick tea infusion (or buttered tea, and urine were collected and measured for fluoride concentrations by the fluoride ion selective electrode method. Results: The fluoride level in all but one of the brick tea samples was above the national standard. The average daily fluoride intake from drinking brick tea in all seven districts in Tibet was much higher than the national standard. The prevalence of dental fluorosis was 33.57%, and the prevalence of clinical skeletal fluorosis was 46.06%. The average daily fluoride intake from drinking brick tea (r = 0.292, P < 0.05, urine fluoride concentrations in children (r = 0.134, P < 0.05, urine fluoride concentrations in adults (r = 0.162, P < 0.05, and altitude (r = 0.276, P < 0.05 were positively correlated with the prevalence of brick tea-type fluorosis. Herdsmen had the highest fluoride exposure and the most severe skeletal fluorosis. Conclusions: Brick tea-type fluorosis in Tibet is more serious than in other parts of China. The altitude and occupational factors are important risk factors for brick tea-type fluorosis.

  9. Elemental Profiles of Whisk(ey Allow Differentiation by Type and Region

    Directory of Open Access Journals (Sweden)

    Helene Hopfer

    2017-01-01

    Full Text Available Elemental fingerprints could provide an analytical approach to product differentiation and authentication, and have been used in the past for various distilled spirits, including brandy, gin, bourbon and tequila. However, a comparison of elemental differences between different whisk(ey types, such as Bourbon and Scotch, is still missing. In this study we compare the elemental fingerprints of 68 commercial whiskies for differentiation by type (Bourbon, Tennessee, Scotch, Irish, Japanese and region. Concentrations from sub-μg/L to mid-mg/L of 53 different elements were determined with inductively-coupled plasma—mass spectrometry (ICP-MS and microwave plasma—atomic emission spectroscopy (MP-AES, and used in subsequent statistical analyses. Significant differences in several elements were found for type, and allowed a classification according to whisk(ey type. Elemental differences were also found for different production areas within Scotland, thus, providing further evidence that Scotch whiskies could be differentiated by elemental analysis. Major sources of elemental differences seem to be processing equipment (Cu, Fe, Ni, Cd, Sn, Mo, V and raw materials, such as water (Ca, Mg, Fe, Mn, Sr.

  10. Regional air-sea coupled model simulation for two types of extreme heat in North China

    Science.gov (United States)

    Li, Donghuan; Zou, Liwei; Zhou, Tianjun

    2018-03-01

    Extreme heat (EH) over North China (NC) is affected by both large scale circulations and local topography, and could be categorized into foehn favorable and no-foehn types. In this study, the performance of a regional coupled model in simulating EH over NC was examined. The effects of regional air-sea coupling were also investigated by comparing the results with the corresponding atmosphere-alone regional model. On foehn favorable (no-foehn) EH days, a barotropic cyclonic (anticyclonic) anomaly is located to the northeast (northwest) of NC, while anomalous northwesterlies (southeasterlies) prevail over NC in the lower troposphere. In the uncoupled simulation, barotropic anticyclonic bias occurs over China on both foehn favorable and no-foehn EH days, and the northwesterlies in the lower troposphere on foehn favorable EH days are not obvious. These biases are significantly reduced in the regional coupled simulation, especially on foehn favorable EH days with wind anomalies skill scores improving from 0.38 to 0.47, 0.47 to 0.61 and 0.38 to 0.56 for horizontal winds at 250, 500 and 850 hPa, respectively. Compared with the uncoupled simulation, the reproduction of the longitudinal position of Northwest Pacific subtropical high (NPSH) and the spatial pattern of the low-level monsoon flow over East Asia are improved in the coupled simulation. Therefore, the anticyclonic bias over China is obviously reduced, and the proportion of EH days characterized by anticyclonic anomaly is more appropriate. The improvements in the regional coupled model indicate that it is a promising choice for the future projection of EH over NC.

  11. Synthesis and magnetic properties of (Eu–Ni) substituted Y-type hexaferrite by surfactant assisted co-precipitation method

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Irshad, E-mail: irshadalibzu@gmail.com [Department of Physics, BahauddinZakariya University, Multan, P.O# 60800 (Pakistan); Islam, M.U. [Department of Physics, BahauddinZakariya University, Multan, P.O# 60800 (Pakistan); Sadiq, Imran [Department of Physics, BahauddinZakariya University, Multan, P.O# 60800 (Pakistan); Centre of Excellence in Solid State Physics, University of The Punjab, Lahore (Pakistan); Karamat, Nazia [Institute of Chemical Science, Bahauddin Zakariya University, Multan 60800 (Pakistan); Iftikhar, Aisha [Department of Physics, BahauddinZakariya University, Multan, P.O# 60800 (Pakistan); Khan, M. Azhar [Department of Physics, Islamia University of Bahawalpur, 63100 Pakistan (Pakistan); Shah, Afzal [Department of Chemistry, Quaid-i-Azam University, Islamabad 45320 (Pakistan); Athar, Muhammad [Institute of Chemical Science, Bahauddin Zakariya University, Multan 60800 (Pakistan); Shakir, Imran [Sustainable Energy Technologies (SET) Center, College of Engineering, King Saud University (Saudi Arabia); Ashiq, Muhammad Naeem, E-mail: naeemashiqqau@yahoo.com [Institute of Chemical Science, Bahauddin Zakariya University, Multan 60800 (Pakistan)

    2015-07-01

    A series of (Eu–Ni) substituted Y-type hexaferrite with composition Sr{sub 2}Co{sub (2−x)}Ni{sub x}Eu{sub y}Fe{sub (12−y)}O{sub 22} (x=0.0–1, Y=0.0–0.1) were prepared by the surfactant assisted co-precipitation method. The present samples were sintered at 1050 °C for 8 h. The shape of the particles is plate-like which is very advantageous for various applications and the grain size varies from 73 to 269 nm. The values of saturation magnetization (M{sub s}), remanent magnetization (M{sub r}) and magnetic moment (n{sub B}) were found to decrease which are attributed to the weakening of super exchange interactions. The values of in-plane Squareness ratios (M{sub r}/M{sub s}) ranging from 0.41 to 0.65 whereas in case of out of plane measurement it varies from 0.30 to 0.62.The investigated samples can be used in perpendicular recording media (PRM) due to high value of coercivity 2300 Oe which is analogous to the those of M-type and W-type hard magnetic. - Highlights: • The present samples sintered at 1050 °C for 8 h. • The grain size varies from 73 to 269 nm. • The magnetic moment varies from 15.27 to 6.07. • The shape of grains is plate like for microwave devices. • The present samples can be used in PRM due to high value of coercivity i.e. 2300 Oe.

  12. Natural type 3/type 2 intertypic vaccine-related poliovirus recombinants with the first crossover sites within the VP1 capsid coding region.

    Science.gov (United States)

    Zhang, Yong; Zhu, Shuangli; Yan, Dongmei; Liu, Guiyan; Bai, Ruyin; Wang, Dongyan; Chen, Li; Zhu, Hui; An, Hongqiu; Kew, Olen; Xu, Wenbo

    2010-12-21

    Ten uncommon natural type 3/type 2 intertypic poliovirus recombinants were isolated from stool specimens from nine acute flaccid paralysis case patients and one healthy vaccinee in China from 2001 to 2008. Complete genomic sequences revealed their vaccine-related genomic features and showed that their first crossover sites were randomly distributed in the 3' end of the VP1 coding region. The length of donor Sabin 2 sequences ranged from 55 to 136 nucleotides, which is the longest donor sequence reported in the literature for this type of poliovirus recombination. The recombination resulted in the introduction of Sabin 2 neutralizing antigenic site 3a (NAg3a) into a Sabin 3 genomic background in the VP1 coding region, which may have been altered by some of the type 3-specific antigenic properties, but had not acquired any type 2-specific characterizations. NAg3a of the Sabin 3 strain seems atypical; other wild-type poliovirus isolates that have circulated in recent years have sequences of NAg3a more like the Sabin 2 strain. 10 natural type 3/type 2 intertypic VP1 capsid-recombinant polioviruses, in which the first crossover sites were found to be in the VP1 coding region, were isolated and characterized. In spite of the complete replacement of NAg3a by type 2-specific amino acids, the serotypes of the recombinants were not altered, and they were totally neutralized by polyclonal type 3 antisera but not at all by type 2 antisera. It is possible that recent type 3 wild poliovirus isolates may be a recombinant having NAg3a sequences derived from another strain during between 1967 and 1980, and the type 3/type 2 recombination events in the 3' end of the VP1 coding region may result in a higher fitness.

  13. Natural type 3/type 2 intertypic vaccine-related poliovirus recombinants with the first crossover sites within the VP1 capsid coding region.

    Directory of Open Access Journals (Sweden)

    Yong Zhang

    Full Text Available BACKGROUND: Ten uncommon natural type 3/type 2 intertypic poliovirus recombinants were isolated from stool specimens from nine acute flaccid paralysis case patients and one healthy vaccinee in China from 2001 to 2008. PRINCIPAL FINDINGS: Complete genomic sequences revealed their vaccine-related genomic features and showed that their first crossover sites were randomly distributed in the 3' end of the VP1 coding region. The length of donor Sabin 2 sequences ranged from 55 to 136 nucleotides, which is the longest donor sequence reported in the literature for this type of poliovirus recombination. The recombination resulted in the introduction of Sabin 2 neutralizing antigenic site 3a (NAg3a into a Sabin 3 genomic background in the VP1 coding region, which may have been altered by some of the type 3-specific antigenic properties, but had not acquired any type 2-specific characterizations. NAg3a of the Sabin 3 strain seems atypical; other wild-type poliovirus isolates that have circulated in recent years have sequences of NAg3a more like the Sabin 2 strain. CONCLUSIONS: 10 natural type 3/type 2 intertypic VP1 capsid-recombinant polioviruses, in which the first crossover sites were found to be in the VP1 coding region, were isolated and characterized. In spite of the complete replacement of NAg3a by type 2-specific amino acids, the serotypes of the recombinants were not altered, and they were totally neutralized by polyclonal type 3 antisera but not at all by type 2 antisera. It is possible that recent type 3 wild poliovirus isolates may be a recombinant having NAg3a sequences derived from another strain during between 1967 and 1980, and the type 3/type 2 recombination events in the 3' end of the VP1 coding region may result in a higher fitness.

  14. Weather Types, temperature and relief relationship in the Iberian Peninsula: A regional adiabatic processes under directional weather types

    Science.gov (United States)

    Peña Angulo, Dhais; Trigo, Ricardo; Cortesi, Nicola; Gonzalez-Hidalgo, Jose Carlos

    2016-04-01

    We have analyzed at monthly scale the spatial distribution of Pearson correlation between monthly mean of maximum (Tmax) and minimum (Tmin) temperatures with weather types (WTs) in the Iberian Peninsula (IP), represent them in a high spatial resolution grid (10km x 10km) from MOTEDAS dataset (Gonzalez-Hidalgo et al., 2015a). The WT classification was that developed by Jenkinson and Collison, adapted to the Iberian Peninsula by Trigo and DaCamara, using Sea Level Pressure data from NCAR/NCEP Reanalysis dataset (period 1951-2010). The spatial distribution of Pearson correlations shows a clear zonal gradient in Tmax under the zonal advection produced in westerly (W) and easterly (E) flows, with negative correlation in the coastland where the air mass come from but positive correlation to the inland areas. The same is true under North-West (NW), North-East (NE), South-West (SW) and South-East (SE) WTs. These spatial gradients are coherent with the spatial distribution of the main mountain chain and offer an example of regional adiabatic phenomena that affect the entire IP (Peña-Angulo et al., 2015b). These spatial gradients have not been observed in Tmin. We suggest that Tmin values are less sensitive to changes in Sea Level Pressure and more related to local factors. These directional WT present a monthly frequency over 10 days and could be a valuable tool for downscaling processes. González-Hidalgo J.C., Peña-Angulo D., Brunetti M., Cortesi, C. (2015a): MOTEDAS: a new monthly temperature database for mainland Spain and the trend in temperature (1951-2010). International Journal of Climatology 31, 715-731. DOI: 10.1002/joc.4298 Peña-Angulo, D., Trigo, R., Cortesi, C., González-Hidalgo, J.C. (2015b): The influence of weather types on the monthly average maximum and minimum temperatures in the Iberian Peninsula. Submitted to Hydrology and Earth System Sciences.

  15. Availability of Foods and Beverages in Supplemental Nutrition Assistance Program-Authorized Dollar Stores in a Region of North Carolina.

    Science.gov (United States)

    Racine, Elizabeth F; Batada, Ameena; Solomon, Corliss A; Story, Mary

    2016-10-01

    There are >25,000 Supplemental Nutrition Assistance Program (SNAP)-authorized dollar stores throughout the United States; many are located in lower-income neighborhoods and provide an accessible food and beverage source for area residents. The purpose of this research was to determine the percent of food deserts within 16 counties in North Carolina that include a SNAP dollar store; examine the types of foods and beverages at SNAP dollar stores in these counties; test whether the foods and beverages offered vary by SNAP dollar store chain; and test whether the foods and beverages available differ by rural and urban location. This cross-sectional study used a combination of publicly available data and primary data to investigate the research questions. Secondary data sources were obtained from the US Department of Agriculture's SNAP retailer locator, the US Census, and the US Department of Agriculture's Food Access Research Atlas. Availability of foods and beverages was assessed among a sample of 90 SNAP dollar stores in 16 counties in southern and western sections of North Carolina. Data were collected in June 2014. About half (52%) of the food deserts in the research area included a SNAP dollar store. Most of the sampled stores sold healthier food staples, such as frozen meats, brown rice, 100% whole-wheat bread, and dried beans. None of the stores sold fresh fruits or vegetables. Some of the foods and beverages offered (eg, frozen fruit, frozen unseasoned vegetables, nonfat or low-fat milk, frozen ground beef) varied by SNAP dollar store chain. The foods and beverages offered did not differ by rural or urban county location. SNAP dollar stores offer a number of healthy food staples; however, they do not sell fresh fruits or vegetables. Further food environment research should include dollar stores. Copyright © 2016 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.

  16. The new Be-type star HD 147196 in the Rho Ophiuchi dark cloud region

    Science.gov (United States)

    The, P. S.; Perez, M. R.; De Winter, D.; Van Den Ancker, M. E.

    1993-01-01

    The newly discovered hot-emission line star, HD 147196 in the Rho Oph dark cloud region was observed spectroscopically and photometrically and high and low resolution IUE spectra were obtained. The finding of Irvine (1990) that this relatively bright star show its H-alpha-line in emission is confirmed. Previous H-alpha-surveys of the Rho Oph star-forming region did not detect HD 147196 as an H-alpha-emission star, meaning that it must recently be very active and has perhaps transformed itself from a B-type star at shell phase to a Be-phase. The Mg II h + k resonance lines are in absorption and they appear to be interstellar in nature, which means that either the abundance of Mg in the extended atmosphere of the star is low or that the shell is not extended enough to produce emission lines of Mg II. Photometric observations of this B8 V type star do not show any variations during at least the years covered by our monitoring or any excess of NIR radiation in its spectral energy distribution up to the M-passband at 4.8 microns.

  17. Regional metallogenic essential factor of granite-type uranium deposits in Guangdong province

    International Nuclear Information System (INIS)

    Pan Yongzheng

    1987-12-01

    The uranium origin, activation region, red basin, and fault depressed zone constitute the regional metallogenic essential factor of the four united like one granite-type uranium deposits in the post-Caledonian rise area in China. In the development of sub-geosyncline in the Caledonian, the clastic formation with widely deposited carbon, silicon, mud rich bearing organic matter, which drow a great amount of uranium formed the uranium-bearing system in the Sinian-Cambrian period. The magmagranite activation in a large scale in the Indosinian-Yenshanian period caused the continental crust to be suffered strong reformation and the uranium-bearing basement system to be eroded and remelted, and formed the rich uranium granite body. The multiple structure-magmatic movement further made the uranium in the rock body suffered the endogenic, structure, supergene active reformation, and produced mobile uranium concentrated area. Under the dry and hot paleoclimate condition in the Cretaceous-Tertiary period, strong weathering and hot water leaching forced uranium to be concentrated into the 'rock origin activation' type uranium deposits in the fault depressed zone

  18. Impact of Circulation Weather Types in the study of Landslides in the Northern Lisbon region

    Science.gov (United States)

    Salvação, Nadia; Trigo, Ricardo; Câmara, Carlos; Zêzere, José Luis

    2010-05-01

    Landslides in the region north of Lisbon during the last 60 years have been induced almost entirely by rainfall, and landslide activity has been confined to very wet periods. Previous results obtained using empirical relationships between rainfall intensity and slope instability show that critical rainfall conditions for failure are not the same for different types of landslides (Zêzere et al, 2008). Shallow translational soil slips have been related to intense rainfall periods ranging from 1 to 15 days, while deep slope movements (translational slides, rotational slides and complex and composite slope movements) have been occurred in relation to longer periods of less intense rain, lasting from 30 to 90 days. The different time span is consistent with the distinct hydrological triggering conditions related to different types of landslides. Intense rainfall is responsible by the rapid growth of pore pressure and by the loss of the apparent cohesion of thin soils, resulting in failure within the soil material or at the contact with the underlying impermeable bedrock. Long lasting precipitation periods allows the steady rising of the groundwater table, thus resulting in deep failures in soils and rocks by the reduction of shear strength. Rainfall information regarding 19 important landslide events occurred between 1958 and 2001, and the knowledge of the circulation weather types (CWTs) affecting those days, allow us to study the relationship between the CWTs frequency and the occurrence of landslide episodes. We have identified 10 basic CWTs (Cyclonic, Anticyclonic and 8 directional types) following the methodology previously adopted (Trigo and DaCamara, 2000). The composites and anomalies of several meteorological fields associated to landslide events show a large precipitation anomaly in the central region of Portugal and an anomalous low-pressure system located northwest of Iberia. This pattern is similar for both shallow and deep landslides events. However, for

  19. Shear strength in corner region of reinforced concrete duct type structures to be embedded in soil

    International Nuclear Information System (INIS)

    Aoyagi, Y.; Endo, T.

    1993-01-01

    Reinforced concrete ducts for accommodating emergency cooling water pipes are generally embedded in soil. The structures is classified as one of the most important structures in terms of earthquake resistant design. During a strong earthquake it is subjected to shear deformations in concerted movement with surrounding soil. The comer regions of the duct should be designed against shear with moment combined. However, the complicated stress conditions in the region render the design more intricate in comparison with the case of simple determinate RC beam type structures. With the above situation in mind an experimental study was conducted, in which prototype as well as one half scale models representing the stress conditions in the region of interest were loaded and brought to failure in shear. The cross section of the prototype test model without shear reinforcements was 60 (height) x 30cm (width), and the tensile reinforcement ratio was 2.58%. The following results were obtained within the limit of the experimental study. (1) The shear capacity predicted by Japanese Design Code for linear RC members over-estimated the experimental ones with a considerably large safety margin of 4.4-5.0. (2) An improved design procedure to be applied to the specific structure was proposed, which gave a reasonable safety factor against shear failure of 1.7-2.0. (3) Combined smeared and discrete cracking model was utilized to simulate the shear failure mechanism, which could realistically pursue experimental behaviors. (author)

  20. Influences of Moisture Regimes and Functional Plant Types on Nutrient Cycling in Permafrost Regions

    Science.gov (United States)

    McCaully, R. E.; Arendt, C. A.; Newman, B. D.; Heikoop, J. M.; Wilson, C. J.; Sevanto, S.; Wales, N. A.; Wullschleger, S.

    2017-12-01

    In the permafrost-dominated Arctic, climatic feedbacks exist between permafrost, soil moisture, functional plant type and presence of nutrients. Functional plant types present within the Arctic regulate and respond to changes in hydrologic regimes and nutrient cycling. Specifically, alders are a member of the birch family that use root nodules to fix nitrogen, which is a limiting nutrient strongly linked to fertilizing Arctic ecosystems. Previous investigations in the Seward Peninsula, AK show elevated presence of nitrate within and downslope of alder patches in degraded permafrost systems, with concentrations an order of magnitude greater than that of nitrate measured above these patches. Further observations within these degraded permafrost systems are crucial to assess whether alders are drivers of, or merely respond to, nitrate fluxes. In addition to vegetative feedbacks with nitrate supply, previous studies have also linked low moisture content to high nitrate production. Within discontinuous permafrost regions, the absence of permafrost creates well-drained regions with unsaturated soils whereas the presence of permafrost limits vertical drainage of soil-pore water creating elevated soil moisture content, which likely corresponds to lower nitrate concentrations. We investigate these feedbacks further in the Seward Peninsula, AK, through research supported by the United States Department of Energy Next Generation Ecosystem Experiment (NGEE) - Arctic. Using soil moisture and thaw depth as proxies to determine the extent of permafrost degradation, we identify areas of discontinuous permafrost over a heterogeneous landscape and collect co-located soilwater chemistry samples to highlight the complex relationships that exist between alder patches, soil moisture regimes, the presence of permafrost and available nitrate supply. Understanding the role of nitrogen in degrading permafrost systems, in the context of both vegetation present and soil moisture, is crucial

  1. Abnormal thalamocortical activity in patients with Complex Regional Pain Syndrome (CRPS) type I.

    Science.gov (United States)

    Walton, K D; Dubois, M; Llinás, R R

    2010-07-01

    Complex Regional Pain Syndrome (CRPS) is a neuropathic disease that presents a continuing challenge in terms of pathophysiology, diagnosis, and treatment. Recent studies of neuropathic pain, in both animals and patients, have established a direct relationship between abnormal thalamic rhythmicity related to Thalamo-cortical Dysrhythmia (TCD) and the occurrence of central pain. Here, this relationship has been examined using magneto-encephalographic (MEG) imaging in CRPS Type I, characterized by the absence of nerve lesions. The study addresses spontaneous MEG activity from 13 awake, adult patients (2 men, 11 women; age 15-62), with CRPS Type I of one extremity (duration range: 3months to 10years) and from 13 control subjects. All CRPS I patients demonstrated peaks in power spectrum in the delta (CRPS Type I patients presented abnormal brain activity typical of TCD, which has both diagnostic value indicating a central origin for this ailment and a potential treatment interest involving pharmacological and electrical stimulation therapies. Copyright 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  2. BPF-type region-of-interest reconstruction for parallel translational computed tomography.

    Science.gov (United States)

    Wu, Weiwen; Yu, Hengyong; Wang, Shaoyu; Liu, Fenglin

    2017-01-01

    The objective of this study is to present and test a new ultra-low-cost linear scan based tomography architecture. Similar to linear tomosynthesis, the source and detector are translated in opposite directions and the data acquisition system targets on a region-of-interest (ROI) to acquire data for image reconstruction. This kind of tomographic architecture was named parallel translational computed tomography (PTCT). In previous studies, filtered backprojection (FBP)-type algorithms were developed to reconstruct images from PTCT. However, the reconstructed ROI images from truncated projections have severe truncation artefact. In order to overcome this limitation, we in this study proposed two backprojection filtering (BPF)-type algorithms named MP-BPF and MZ-BPF to reconstruct ROI images from truncated PTCT data. A weight function is constructed to deal with data redundancy for multi-linear translations modes. Extensive numerical simulations are performed to evaluate the proposed MP-BPF and MZ-BPF algorithms for PTCT in fan-beam geometry. Qualitative and quantitative results demonstrate that the proposed BPF-type algorithms cannot only more accurately reconstruct ROI images from truncated projections but also generate high-quality images for the entire image support in some circumstances.

  3. Stable isotope-assisted NMR characterization of interaction between lipid A and sarcotoxin IA, a cecropin-type antibacterial peptide

    Energy Technology Data Exchange (ETDEWEB)

    Yagi-Utsumi, Maho [Institute for Molecular Science and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787 (Japan); Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan); Yamaguchi, Yoshiki [Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan); Advanced Science Institute, RIKEN, Wako 351-0198 (Japan); Boonsri, Pornthip [Institute for Molecular Science and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787 (Japan); Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900 (Thailand); Iguchi, Takeshi [Bioscience Research Laboratory, Fujiya Co., Ltd., Hadano, Kanagawa 257-0031 (Japan); Okemoto, Kazuo [Department of Biochemistry and Cell Biology, National Institute of Infectious Disease, Tokyo 162-8640 (Japan); Natori, Shunji [National Institute of Agrobiological Sciences, Tsukuba 305-8602 (Japan); Kato, Koichi, E-mail: kkatonmr@ims.ac.jp [Institute for Molecular Science and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444-8787 (Japan); Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603 (Japan); The Glycoscience Institute, Ochanomizu University, Tokyo 135-0064 (Japan); GLYENCE Co., Ltd., Nagoya 474-0858 (Japan)

    2013-02-08

    Highlights: ► Recombinant sarcotoxin IA was successfully produced with {sup 13}C- and {sup 15}N-labeling. ► Sarcotoxin IA adopts an N-terminal α-helix upon binding to lipid A-embedding micelles. ► Two lysine residues are involved in lipid A-mediated antibacterial activities. -- Abstract: Sarcotoxin IA is a 39-residue cecropin-type peptide from Sarcophaga peregrina. This peptide exhibits antibacterial activity against Gram-negative bacteria through its interaction with lipid A, a core component of lipopolysaccharides. To acquire detailed structural information on this specific interaction, we performed NMR analysis using bacterially expressed sarcotoxin IA analogs with {sup 13}C- and {sup 15}N-labeling along with lipid A-embedding micelles composed of dodecylphosphocholine. By inspecting the stable isotope-assisted NMR data, we revealed that the N-terminal segment (Leu3–Arg18) of sarcotoxin IA formed an amphiphilic α-helix upon its interaction with the aqueous micelles. Furthermore, chemical shift perturbation data indicated that the amino acid residues displayed on this α-helix were involved in the specific interaction with lipid A. On the basis of these data, we successfully identified Lys4 and Lys5 as key residues in the interaction with lipid A and the consequent antibacterial activity. Therefore, these results provide unique information for designing chemotherapeutics based on antibacterial peptide structures.

  4. On the issue of methodology of estimating the regional competitive advantages by types of activity

    Directory of Open Access Journals (Sweden)

    Azat Rashitovich Safiullin

    2015-06-01

    Full Text Available Objective to develop the research methodology of the competitive position of territories by types of economic activities to define the relevant types of economic activities and to diagnose their competitive advantages. Methods a differentiated approach to the analysis of competitiveness based on matrix models of competitive positioning which allows to identify the relevant types of economic activities of the territory. This approach determined the choice of specific research methods dialectics abstraction systematic logical structural comparative and statistical. The application of the above methods helped to ensure the validity of the analysis results theoretical and practical conclusions. Results in the study were used the experience and knowledge gained during an earlier undertaken series of projects relating to the assessment of economy efficiency of Tatarstan Republic in 20052011.Previous reports dealt with the change of the selected industries positions of the Republic the structure and dynamics of the competitive position of these industries compared to the leading Russian regions. A distinctive feature of the research results presented in this article is a comparative analysis of competitive advantages of economic activities of Tatarstan Republic based on the matrix model of competitive positioning. Scientific novelty for the first time the matrix model of diagnostics of competitive advantages of the territory by the type of economic activity was proposed which allows to identify the priority industrial portfolio and provide targeted management actions to enhance its investment attractiveness. Practical value the main provisions and conclusions of the article can be used by legislative and executive authorities of the Russian Federation business community research institutions and organizations to develop strategies and programs of socioeconomic development and territorial planning schemes priority directions of industrial and investment

  5. The managed clearing: An overlooked land-cover type in urbanizing regions?

    Science.gov (United States)

    Madden, Marguerite; Gray, Josh; Meentemeyer, Ross K.

    2018-01-01

    Urban ecosystem assessments increasingly rely on widely available map products, such as the U.S. Geological Service (USGS) National Land Cover Database (NLCD), and datasets that use generic classification schemes to detect and model large-scale impacts of land-cover change. However, utilizing existing map products or schemes without identifying relevant urban class types such as semi-natural, yet managed land areas that account for differences in ecological functions due to their pervious surfaces may severely constrain assessments. To address this gap, we introduce the managed clearings land-cover type–semi-natural, vegetated land surfaces with varying degrees of management practices–for urbanizing landscapes. We explore the extent to which managed clearings are common and spatially distributed in three rapidly urbanizing areas of the Charlanta megaregion, USA. We visually interpreted and mapped fine-scale land cover with special attention to managed clearings using 2012 U.S. Department of Agriculture (USDA) National Agriculture Imagery Program (NAIP) images within 150 randomly selected 1-km2 blocks in the cities of Atlanta, Charlotte, and Raleigh, and compared our maps with National Land Cover Database (NLCD) data. We estimated the abundance of managed clearings relative to other land use and land cover types, and the proportion of land-cover types in the NLCD that are similar to managed clearings. Our study reveals that managed clearings are the most common land cover type in these cities, covering 28% of the total sampled land area– 6.2% higher than the total area of impervious surfaces. Managed clearings, when combined with forest cover, constitutes 69% of pervious surfaces in the sampled region. We observed variability in area estimates of managed clearings between the NAIP-derived and NLCD data. This suggests using high-resolution remote sensing imagery (e.g., NAIP) instead of modifying NLCD data for improved representation of spatial heterogeneity and

  6. Outbreak of type C botulism in birds and mammals in the Emilia Romagna region, northern Italy.

    Science.gov (United States)

    Defilippo, Francesco; Luppi, Andrea; Maioli, Giulia; Marzi, Dario; Fontana, Maria Cristina; Paoli, Federica; Bonilauri, Paolo; Dottori, Michele; Merialdi, Giuseppe

    2013-10-01

    Over a 7-day period beginning 8 August 2011, a large number of wild birds of several species were found dead or with neurologic clinical signs along the shore of Crostolo stream, in the Emilia Romagna region, Italy. Twenty-eight Mallards (Anas platyrhynchos), two Hooded Crows (Corvus corone cornix), and three coypus (Myocastor coypus) were found moribund on the Crostolo stream bank, collected, and sent to Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, Reggio Emilia Section. The cause of mortality was determined to be Clostridium botulinum type C toxin. The toxin was identified by a mouse bioassay for botulinum toxins and confirmed in bird sera and blowfly larvae (Lucilia caesar) collected from the stomachs of birds.

  7. Statistical Study of Corrosion Types in Constructions in South Region of Rio De Janeiro – Brazil

    Directory of Open Access Journals (Sweden)

    Carolina Lacerda da Cruz

    2016-05-01

    Full Text Available Some of the most difficult and troubling problems encountered in construction are those caused by corrosive processes. The corrosion processes are constituted by some material degradation, generally metallic material, by means of chemical or electrochemical actions of environment in which the material are and can or cannot be combined with mechanical stress. Corrosion is present in the materials in general. Their deterioration is caused by such physical-chemical interaction between the material and the corrosive environment where it causes major problems in several activities. In order to prevent material losses, anticorrosive techniques are used which include coatings, medium modification techniques, anodic and cathodic protection, and corrosion inhibitors such as the organic compounds use. This article analyses the statistical study of corrosion types in construction in south region of Rio de Janeiro, Brazil.

  8. Different geographies and experiences of 'assisted' types of migration. A gendered critique on the distinction between trafficking and smuggling.

    NARCIS (Netherlands)

    Liempt, I.C. van

    2011-01-01

    This article presents three stories of female migrants who were assisted in their migration process from the Horn of Africa, Iraq and the former Soviet Union to the Netherlands. The stories are contextualized within the results of a wider research project on assisted migration involving 56

  9. Planetary and tidal wave-type oscillations in the ionospheric sporadic E layers over Tehran region

    Science.gov (United States)

    Karami, K.; Ghader, S.; Bidokhti, A. A.; Joghataei, M.; Neyestani, A.; Mohammadabadi, A.

    2012-04-01

    It is believed that in the lower ionosphere, particularly in the ionospheric sporadic E (Es) layers (90-130 km), the planetary and tidal wave-type oscillations in the ionized component indicate the planetary and tidal waves in the neutral atmosphere. In the present work, the presence of wave-type oscillations, including planetary and tidal waves in the ionospheric sporadic E layers over Tehran region is examined. Data measured by a digital ionosonde at the ionospheric station of the Institute of Geophysics, University of Tehran, from July 2006 to June 2007 are used to investigate seasonal variations of planetary and tidal waves activities. For the purpose of accurate comparison between different seasons, wavelet transform is applied to time series of foEs and h‧Es, namely, the critical frequency and virtual height of Es layers, respectively. The results show that the sporadic E layers over Tehran region are strongly under the influence of upward propagation of waves from below. More specifically, among diverse range of periodicities in the sporadic E layers, we found that diurnal (24 hours) and semidiurnal (12 hours) oscillations in all seasons for both parameters. Moreover, terdiurnal (8 hours) tide-like variation is observed during spring and summer for foEs parameter and summer and winter for h‧Es. Furthermore, the results show that diurnal tidal waves obtain their maximum activities during autumn and winter seasons, and their activities decrease during the late spring and summer. In addition, periods of about 2, 4, 6, 10, 14, and 16 days in our observation verifies the hypothesis of upward propagation of planetary waves from lower atmosphere to the ionosphere. Moreover, planetary waves have their maximum activities during equinox.

  10. Organic carbon storage in four ecosystem types in the karst region of southwestern China.

    Directory of Open Access Journals (Sweden)

    Yuguo Liu

    Full Text Available Karst ecosystems are important landscape types that cover about 12% of the world's land area. The role of karst ecosystems in the global carbon cycle remains unclear, due to the lack of an appropriate method for determining the thickness of the solum, a representative sampling of the soil and data of organic carbon stocks at the ecosystem level. The karst region in southwestern China is the largest in the world. In this study, we estimated biomass, soil quantity and ecosystem organic carbon stocks in four vegetation types typical of karst ecosystems in this region, shrub grasslands (SG, thorn shrubbery (TS, forest - shrub transition (FS and secondary forest (F. The results showed that the biomass of SG, TS, FS, and F is 0.52, 0.85, 5.9 and 19.2 kg m(-2, respectively and the corresponding organic cabon storage is 0.26, 0.40, 2.83 and 9.09 kg m(-2, respectively. Nevertheless, soil quantity and corresponding organic carbon storage are very small in karst habitats. The quantity of fine earth overlaying the physical weathering zone of the carbonate rock of SG, TS, FS and F is 38.10, 99.24, 29.57 and 61.89 kg m(-2, respectively, while the corresponding organic carbon storage is only 3.34, 4.10, 2.37, 5.25 kg m(-2, respectively. As a whole, ecosystem organic carbon storage of SG, TS, FS, and F is 3.81, 4.72, 5.68 and 15.1 kg m(-2, respectively. These are very low levels compared to other ecosystems in non-karst areas. With the restoration of degraded vegetation, karst ecosystems in southwestern China may play active roles in mitigating the increasing CO2 concentration in the atmosphere.

  11. [Exploration for micro-osteotomy assisted orthodontic treatment of skeletal Class III malocclusions with alveolar hypoplasia in the lower anterior region].

    Science.gov (United States)

    Wang, Bo; Shen, Guo-fang; Fang, Bing; Sun, Liang-yan; Wu, Yong; Jiang, Ling-yong; Zhu, Min

    2012-10-01

    To investigate the changes of periodontal conditions after micro-osteotomy assisted lower incisor decompensation for skeletal Class III malocclusions with alveolar hypoplasia in the lower anterior region. The sample consisted of 22 cases diagnosed as skeletal Class III malocclusions with alveolar hypoplasia in the lower anterior region, selected from consecutive patients of Department of Oral & Cranio-maxillofacial Science of Shanghai Ninth People's Hospital during 2009-2012. The samples were divided into 2 groups; G1 comprised 10 patients who accepted micro-osteotomy assisted lower incisor decompensation; G2 comprised 12 patients who chose traditional pre-surgical decomposition. The changes of periodontal conditions of both groups were evaluated with the help of cone-beam CT(CBCT). Data was processed using SAS8.02 software package. For subjects in G1, during the micro-osteotomy assisted pre-surgical orthodontics, no significant difference was found in the amount of root resorption of lower incisors.But labial and lingual vertical alveolar bone loss were 2.60 mm and 2.22 mm; alveolar bone thickness increased by 3.05 mm on the labial side and decreased by 0.88 mm on the lingual side (Ppre-surgical orthodontics was much safer than traditional orthodontics for skeletal Class III malocclusions with alveolar hypoplasia in the lower anterior region.

  12. Regional cerebral blood flow and brain atrophy in senile dementia of Alzheimer type (SDAT)

    International Nuclear Information System (INIS)

    Okada, Kazunori; Kobayashi, Shoutai; Yamaguchi, Shuhei; Kitani, Mituhiro; Tsunematsu, Tokugoro

    1987-01-01

    To investigate the relationship between the reduction of cerebal blood flow and brain atrophy in SDAT, these were measured in 13 cases of senile dementia of Alzheimer type, and compared to 15 cases of multi-infarct Dementia, 39 cases of lacunar infarction without dementia (non-demented CVD group) and 69 cases of aged normal control. Brain atrophy was evaluated by two-dimensional method on CT film by digitizer and regional cerebral blood flow (rCBF) was measured by 133 Xe inhalation method. The degree of brain atrophy in SDAT was almost similar of that of MID. But it was more severe than that of non-demented group. MID showed the lowest rCBF among these groups. SDAT showed significantly lower rCBF than that of aged control, but rCBF in SDAT was equal to that of lacunar stroke without dementia. Focal reduction of cerebral blood flow in bilateral fronto-parietal and left occipital regions were observed in SDAT. Verbal intelligence score (Hasegawa's score) correlated with rCBF and brain atrophy index in MID, and a tendency of correlation between rCBF and brain atrophy in MID was also observed. However, there was no correlation among those indices in SDAT. These findings suggest that the loss of brain substance dose not correspond to the reduction of rCBF in SDAT and simultaneous measurement of rCBF and brain atrophy was useful to differ SDAT from MID. (author)

  13. Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012.

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    Katharine J Looker

    Full Text Available Herpes simplex virus type 1 (HSV-1 commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated.We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital.We estimated that 3709 million people (range: 3440-3878 million aged 0-49 years had prevalent HSV-1 infection in 2012 (67%, with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific.The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection.

  14. Transcriptional regulatory elements in the noncoding region of human papillomavirus type 6

    International Nuclear Information System (INIS)

    Wu, Tzyy-Choou.

    1989-01-01

    The structure and function of the transcriptional regulatory region of human papillomavirus type 6 (HPV-6) has been investigated. To investigate tissue specific gene expression, a sensitive method to detect and localize HPV-6 viral DNA, mRNA and protein in plastic-embedded tissue sections of genital and respiratory tract papillomata by using in situ hybridization and immunoperoxidase assays has been developed. This method, using ultrathin sections and strand-specific 3 H labeled riboprobes, offers the advantages of superior morphological preservation and detection of viral genomes at low copy number with good resolution, and the modified immunocytochemistry provides better sensitivity. The results suggest that genital tract epithelium is more permissive for HPV-6 replication than respiratory tract epithelium. To study the tissue tropism of HPV-6 at the level of regulation of viral gene expression, the polymerase chain reaction was used to isolate the noncoding region (NCR) of HPV-6 in independent isolates. Nucleotide sequence analysis of molecularly cloned DNA identified base substitutions, deletions/insertions and tandem duplications. Transcriptional regulatory elements in the NCR were assayed in recombinant plasmids containing the bacterial gene for chloramphenicol acetyl transferase

  15. Efficacy of Botulinum Toxin Injections in the Treatment of Various Types of Facial Region Disorders

    Directory of Open Access Journals (Sweden)

    Arzu Çoban

    2012-12-01

    Full Text Available OBJECTIVE: Local injection of botulinum toxin is a highly effective treatment option for a wide range of movement disorders and there are reliable sources of information on its indications, effects and safety in clinical practice. In this study, we report our experience with botulinum toxin in the treatment of facial region disorders. METHODS: Patients who had been followed in the Botulinum Toxin Outpatient Clinic of the Neurology Department were retrospectively evaluated. Two preparations of botulinum toxin type A (BT-A were used. The efficacy of BT-A injections was rated according to the improvement in symptoms as follows: marked - 75-100% improvement, good - 50-74%, moderate - 25-49%, and insufficient - less than 25% symptom relief. RESULTS: One hundred eighty-two patients (73 male, 109 female with various facial region disorders were included. The efficacy rates for patients who had very good and good improvement were high in the treatment of blepharospasm, hemifacial spasm, facial synkinesis, and Meige syndrome and moderate for oromandibular dystonia and hypersalivation. Ptosis was the most common side effect. CONCLUSION: According to our results, botulinum toxin was very effective treatment for blepharospasm, Meige syndrome, hemifacial spasm and facial synkinesis, whereas it demonstrated good efficacy in oromandibular dystonia and hypersalivation

  16. Identification of candidate regions for a novel Usher syndrome type II locus.

    Science.gov (United States)

    Ben Rebeh, Imen; Benzina, Zeineb; Dhouib, Houria; Hadjamor, Imen; Amyere, Mustapha; Ayadi, Leila; Turki, Khalil; Hammami, Bouthaina; Kmiha, Noureddine; Kammoun, Hassen; Hakim, Bochra; Charfedine, Ilhem; Vikkula, Miikka; Ghorbel, Abdelmonem; Ayadi, Hammadi; Masmoudi, Saber

    2008-09-19

    Chronic diseases affecting the inner ear and the retina cause severe impairments to our communication systems. In more than half of the cases, Usher syndrome (USH) is the origin of these double defects. Patients with USH type II (USH2) have retinitis pigmentosa (RP) that develops during puberty, moderate to severe hearing impairment with downsloping pure-tone audiogram, and normal vestibular function. Four loci and three genes are known for USH2. In this study, we proposed to localize the gene responsible for USH2 in a consanguineous family of Tunisian origin. Affected members underwent detailed ocular and audiologic characterization. One Tunisian family with USH2 and 45 healthy controls unrelated to the family were recruited. Two affected and six unaffected family members attended our study. DNA samples of eight family members were genotyped with polymorphic markers. Two-point and multipoint LOD scores were calculated using Genehunter software v2.1. Sequencing was used to investigate candidate genes. Haplotype analysis showed no significant linkage to any known USH gene or locus. A genome-wide screen, using microsatellite markers, was performed, allowing the identification of three homozygous regions in chromosomes 2, 4, and 15. We further confirmed and refined these three regions using microsatellite and single-nucleotide polymorphisms. With recessive mode of inheritance, the highest multipoint LOD score of 1.765 was identified for the candidate regions on chromosomes 4 and 15. The chromosome 15 locus is large (55 Mb), underscoring the limited number of meioses in the consanguineous pedigree. Moreover, the linked, homozygous chromosome 15q alleles, unlike those of the chromosome 2 and 4 loci, are infrequent in the local population. Thus, the data strongly suggest that the novel locus for USH2 is likely to reside on 15q. Our data provide a basis for the localization and the identification of a novel gene implicated in USH2, most likely localized on 15q.

  17. Changes in Area of Timberland in the United States, 1952-2040, By Ownership, Forest Type, Region, and State

    Science.gov (United States)

    Ralph J. Allg; William G. Hohenstein; Brian C. Murray; Robert G. Haight

    1990-01-01

    Area change projections for timberland in the United Steats are provided by region, State, ownership, and forest type.Total timberland area is projected to drop by 21 million acres or 4 percent by the year 2040.

  18. Correlation connection between the anomalous magnetic and gravitational fields for regions with different types of the Earth's crust

    International Nuclear Information System (INIS)

    Lugovenko, V.N.; Pronin, V.P.; Kosheleva, L.V.

    1989-01-01

    A method for the correlation analysis of anomalous geophysical fields at different survey altitudes is proposed. The joint correlation analysis is performed for anomalous magnetic and gravitational fields for regions with different types of the Earth's crust. (author)

  19. The relationship between urban neighbourhood type and commuting distance in Gauteng City region, South Africa. A preliminary analysis

    CSIR Research Space (South Africa)

    Moselakgomo, M

    2013-07-01

    Full Text Available This paper uses the 2001 and 2013 Gauteng household travel survey datasets to investigate the nature of change in commuting distances of commuters from different neighbourhood types in the Gauteng City Region, in South Africa. The investigation...

  20. Personality assessment of patients with complex regional pain syndrome type I.

    Science.gov (United States)

    Monti, D A; Herring, C L; Schwartzman, R J; Marchese, M

    1998-12-01

    There is controversy regarding the importance of psychological/psychiatric factors in the development of the Complex Regional Pain Syndrome (CRPS). Our objective was to determine whether CRPS type I patients were psychiatrically different from other chronic pain patients, with particular attention to personality pathology. A standardized clinical assessment of all major psychiatric categories, including personality disorders, was performed on 25 CRPS type I patients and a control group of 25 patients with chronic low back pain from disc-related radiculopathy. Both sections of the Structured Clinical Interview for the Diagnostic and Statistical Manual (3rd ed., rev.) and the visual analog scale. Both groups were similar in terms of pain intensity and duration. Statistical analysis showed both groups to have a significant amount of major psychiatric comorbidity, in particular major depressive disorder, and a high incidence of personality disorders. Therefore, intense chronic pain was associated with significant psychiatric comorbidity in both groups and in similar proportions. The high incidence of personality pathology in both groups may represent an exaggeration of maladaptive personality traits and coping styles as a result of a chronic, intense, state of pain.

  1. High frequency ion sound waves associated with Langmuir waves in type III radio burst source regions

    Directory of Open Access Journals (Sweden)

    G. Thejappa

    2004-01-01

    Full Text Available Short wavelength ion sound waves (2-4kHz are detected in association with the Langmuir waves (~15-30kHz in the source regions of several local type III radio bursts. They are most probably not due to any resonant wave-wave interactions such as the electrostatic decay instability because their wavelengths are much shorter than those of Langmuir waves. The Langmuir waves occur as coherent field structures with peak intensities exceeding the Langmuir collapse thresholds. Their scale sizes are of the order of the wavelength of an ion sound wave. These Langmuir wave field characteristics indicate that the observed short wavelength ion sound waves are most probably generated during the thermalization of the burnt-out cavitons left behind by the Langmuir collapse. Moreover, the peak intensities of the observed short wavelength ion sound waves are comparable to the expected intensities of those ion sound waves radiated by the burnt-out cavitons. However, the speeds of the electron beams derived from the frequency drift of type III radio bursts are too slow to satisfy the needed adiabatic ion approximation. Therefore, some non-linear process such as the induced scattering on thermal ions most probably pumps the beam excited Langmuir waves towards the lower wavenumbers, where the adiabatic ion approximation is justified.

  2. Brain local and regional neuroglial alterations in Alzheimer's Disease: cell types, responses and implications.

    Science.gov (United States)

    Toledano, Adolfo; Álvarez, María-Isabel; Toledano-Díaz, Adolfo; Merino, José-Joaquín; Rodríguez, José Julio

    2016-01-01

    From birth to death, neurons are dynamically accompanied by neuroglial cells in a very close morphological and functional relationship. Three families have been classically considered within the CNS: astroglia, oligodendroglia and microglia. Many types/subtypes (including NGR2+ cells), with a wide variety of physiological and pathological effects on neurons, have been described using morphological and immunocytochemical criteria. Glio-glial, glio-neuronal and neuro-glial cell signaling and gliotransmission are phenomena that are essential to support brain functions. Morphofunctional changes resulting from the plasticity of all the glial cell types parallel the plastic neuronal changes that optimize the functionality of neuronal circuits. Moreover, neuroglia possesses the ability to adopt a reactive status (gliosis) in which, generally, new functions arise to improve and restore if needed the neural functionality. All these features make neuroglial cells elements of paramount importance when attempting to explain any physiological or pathological processes in the CNS, because they are involved in both, neuroprotection/neurorepair and neurodegeneration. There exist diverse and profound, regional and local, neuroglial changes in all involutive processes (physiological and pathological aging; neurodegenerative disorders, including Alzheimer ´s disease -AD-), but today, the exact meaning of such modifications (the modifications of the different neuroglial types, in time and place), is not well understood. In this review we consider the different neuroglial cells and their responses in order to understand the possible role they fulfill in pathogenesis, diagnosis and treatment (preventive or palliative) of AD. The existence of differentiated and/or concurrent pathogenic and neuro-protective/neuro-restorative astroglial and microglial responses is highlighted.

  3. Endoscopic-assisted interhemispheric parieto-occipital transtentorial approach for microsurgical resection of a pineal region tumor: operative video and technical nuances.

    Science.gov (United States)

    Liu, James K

    2016-01-01

    The angle of the straight sinus and tentorium cerebelli can often influence the choice of surgical approach to the pineal region. The supracerebellar infratentorial approach can be technically challenging and a relative contraindication in cases where the angle of the straight sinus and tentorium is very steep. Similarly, an occipital transtentorial approach, which uses a low occipital craniotomy at the junction of the superior sagittal sinus and transverse sinus, may not provide the best trajectory to the pineal region in patients with a steep tentorium. In addition, this approach often necessitates retraction on the occipital lobe to access the tentorial incisura and pineal region, which can increase the risk of visual compromise. In this operative video, the author demonstrates an alternative route using an endoscopic-assisted interhemispheric parieto-occipital transtentorial approach to a pineal region tumor in a patient with a steep straight sinus and tentorium. The approach provided a shorter route and more direct trajectory to the tumor at the tentorial incisura, and avoided direct fixed retraction on the occipital lobe when performed using the lateral position, thereby minimizing visual complications. This video atlas demonstrates the operative technique and surgical nuances, including the application of endoscopic-assisted microsurgical resection and operative pearls for preservation of the deep cerebral veins. In summary, the parieto-occipital transtentorial approach with endoscopic assistance is an important approach in the armamentarium for surgical management of pineal region tumors. The video can be found here: https://youtu.be/Ph4veG14aTk .

  4. Flow-type landslides magnitude evaluation: the case study of the Campania Region (Southern Italy)

    Science.gov (United States)

    Santo, Antonio; De Falco, Melania; Di Crescenzo, Giuseppe

    2015-04-01

    In the last years studies concerning the triggering and the run-out susceptibility for different kind of landslides have become more and more precise. In the most of the cases the methodological approach involve the production of detailed thematic maps (at least 1:5000 scale) which represent a very useful tool for territorial planning, especially in urbanized areas. More recently these researches were accompanied by the growth of other studies dealing with landslide magnitude evaluation (especially in terms of volume and velocity estimate). In this paper the results of a flow-type landslides magnitude evaluation are presented. The study area is located in Southern Italy and is very wide (1,500 square kilometres) including all the Campania region. In this context flow type landslides represent the most frequent instabilities as shown by the large number of victims and the huge economic damage caused in the last few centuries. These shallow landslides involve thin cohesionless, unsaturated pyroclastic soils found over steep slopes around Somma-Vesuvio and Phlegrean district, affecting a wide area where over 100 towns are located. Since the potential volume of flow-type landslides is a measure of event magnitude we propose to estimate the potential volume at the scale of slope or basin for about 90 municipalities affecting 850 hierarchized drainage basins and 900 regular slopes. An empirical approach recently proposed in literature (De Falco et al., 2012), allows to estimate the volume of the pyroclastic cover that can be displaced along the slope. The method derives from the interpretation of numerous geological and geomorphological data gathered from a vast amount of case histories on landslides in volcanic and carbonatic contexts and it is based on determining the thickness of the pyroclastic cover and the width of the detachment and erosion-transport zone. Thickness can be evaluated with a good degree of approximation since, in these landslides, the failure

  5. Complex Regional Pain Syndrome Type I Affects Brain Structure in Prefrontal and Motor Cortex

    Science.gov (United States)

    Pleger, Burkhard; Draganski, Bogdan; Schwenkreis, Peter; Lenz, Melanie; Nicolas, Volkmar; Maier, Christoph; Tegenthoff, Martin

    2014-01-01

    The complex regional pain syndrome (CRPS) is a rare but debilitating pain disorder that mostly occurs after injuries to the upper limb. A number of studies indicated altered brain function in CRPS, whereas possible influences on brain structure remain poorly investigated. We acquired structural magnetic resonance imaging data from CRPS type I patients and applied voxel-by-voxel statistics to compare white and gray matter brain segments of CRPS patients with matched controls. Patients and controls were statistically compared in two different ways: First, we applied a 2-sample ttest to compare whole brain white and gray matter structure between patients and controls. Second, we aimed to assess structural alterations specifically of the primary somatosensory (S1) and motor cortex (M1) contralateral to the CRPS affected side. To this end, MRI scans of patients with left-sided CRPS (and matched controls) were horizontally flipped before preprocessing and region-of-interest-based group comparison. The unpaired ttest of the “non-flipped” data revealed that CRPS patients presented increased gray matter density in the dorsomedial prefrontal cortex. The same test applied to the “flipped” data showed further increases in gray matter density, not in the S1, but in the M1 contralateral to the CRPS-affected limb which were inversely related to decreased white matter density of the internal capsule within the ipsilateral brain hemisphere. The gray-white matter interaction between motor cortex and internal capsule suggests compensatory mechanisms within the central motor system possibly due to motor dysfunction. Altered gray matter structure in dorsomedial prefrontal cortex may occur in response to emotional processes such as pain-related suffering or elevated analgesic top-down control. PMID:24416397

  6. Complex regional pain syndrome type I affects brain structure in prefrontal and motor cortex.

    Directory of Open Access Journals (Sweden)

    Burkhard Pleger

    Full Text Available The complex regional pain syndrome (CRPS is a rare but debilitating pain disorder that mostly occurs after injuries to the upper limb. A number of studies indicated altered brain function in CRPS, whereas possible influences on brain structure remain poorly investigated. We acquired structural magnetic resonance imaging data from CRPS type I patients and applied voxel-by-voxel statistics to compare white and gray matter brain segments of CRPS patients with matched controls. Patients and controls were statistically compared in two different ways: First, we applied a 2-sample ttest to compare whole brain white and gray matter structure between patients and controls. Second, we aimed to assess structural alterations specifically of the primary somatosensory (S1 and motor cortex (M1 contralateral to the CRPS affected side. To this end, MRI scans of patients with left-sided CRPS (and matched controls were horizontally flipped before preprocessing and region-of-interest-based group comparison. The unpaired ttest of the "non-flipped" data revealed that CRPS patients presented increased gray matter density in the dorsomedial prefrontal cortex. The same test applied to the "flipped" data showed further increases in gray matter density, not in the S1, but in the M1 contralateral to the CRPS-affected limb which were inversely related to decreased white matter density of the internal capsule within the ipsilateral brain hemisphere. The gray-white matter interaction between motor cortex and internal capsule suggests compensatory mechanisms within the central motor system possibly due to motor dysfunction. Altered gray matter structure in dorsomedial prefrontal cortex may occur in response to emotional processes such as pain-related suffering or elevated analgesic top-down control.

  7. HIGH-VELOCITY LINE FORMING REGIONS IN THE TYPE Ia SUPERNOVA 2009ig

    International Nuclear Information System (INIS)

    Marion, G. H.; Foley, Ryan J.; Challis, Peter; Kirshner, Robert P.; Vinko, Jozsef; Wheeler, J. Craig; Silverman, Jeffrey M.; Hsiao, Eric Y.; Brown, Peter J.; Filippenko, Alexei V.; Garnavich, Peter; Landsman, Wayne B.; Parrent, Jerod T.; Pritchard, Tyler A.; Roming, Peter W. A.; Wang, Xiaofeng

    2013-01-01

    We report measurements and analysis of high-velocity (HVF) (>20,000 km s –1 ) and photospheric absorption features in a series of spectra of the Type Ia supernova (SN) 2009ig obtained between –14 days and +13 days with respect to the time of maximum B-band luminosity (B-max). We identify lines of Si II, Si III, S II, Ca II, and Fe II that produce both HVF and photospheric-velocity (PVF) absorption features. SN 2009ig is unusual for the large number of lines with detectable HVF in the spectra, but the light-curve parameters correspond to a slightly overluminous but unexceptional SN Ia (M B = –19.46 mag and Δm 15 (B) = 0.90 mag). Similarly, the Si II λ6355 velocity at the time of B-max is greater than 'normal' for an SN Ia, but it is not extreme (v Si = 13,400 km s –1 ). The –14 days and –13 days spectra clearly resolve HVF from Si II λ6355 as separate absorptions from a detached line forming region. At these very early phases, detached HVF are prevalent in all lines. From –12 days to –6 days, HVF and PVF are detected simultaneously, and the two line forming regions maintain a constant separation of about 8000 km s –1 . After –6 days all absorption features are PVF. The observations of SN 2009ig provide a complete picture of the transition from HVF to PVF. Most SNe Ia show evidence for HVF from multiple lines in spectra obtained before –10 days, and we compare the spectra of SN 2009ig to observations of other SNe. We show that each of the unusual line profiles for Si II λ6355 found in early-time spectra of SNe Ia correlate to a specific phase in a common development sequence from HVF to PVF

  8. Epidemiological networks and drug resistance of HIV type 1 in Krasnoyarsk region, Russia

    NARCIS (Netherlands)

    Rumyantseva, Olga A.; Olkhovskiy, Igor A.; Malysheva, Marina A.; Ruzaeva, Ludmila A.; Vasiliev, Alexander V.; Kazennova, Elena V.; Bobkova, Marina R.; Lukashov, Vladimir V.

    2009-01-01

    To study the molecular epidemiology of HIV-1 in Krasnoyarsk region, Russia, where HIV-1 has spread rapidly since 2000, we obtained pol sequences from individuals living in this region (n = 67) as well as in the geographically closely related Altay region (n = 13). In both regions, subtype A viruses

  9. New Comparative Experiments of Different Soil Types for Farmland Water Conservation in Arid Regions

    Directory of Open Access Journals (Sweden)

    Yiben Cheng

    2018-03-01

    Full Text Available Irrigated farmland is the main food source of desert areas, and moisture is the main limiting factor of desert farmland crop productivity. Study on the influence of irrigation on desert farmland soil moisture can guide the agricultural water resource utilization and agricultural production in those regions. At present, the efficiency of irrigation water usage in Northwest China is as low as approximately 40% of the irrigated water. To understand the response of farmland soil moisture in different soil types on irrigation in the Ulan Buh Desert of Inner Mongolia of China, this experimental study takes advantage of different infiltration characteristics and hydraulic conductivities of sand, clay, and loam to determine an optimized soil combination scheme with the purpose of establishing a hydraulic barrier that reduces infiltration. This study includes three comparative experiments with each consisting of a 100 cm thick of filled sand, or clay, or loam soil underneath a 50 cm plough soil, with a total thickness of 150 cm soil profile. A new type of lysimeter is installed below the above-mentioned 150 cm soil profile to continuously measure deep soil recharge (DSR, and the ECH2O-5 soil moisture sensors are installed at different depths over the 150 cm soil profile to simultaneously monitor the soil moisture above the lysimeter. The study analyzes the characteristics of soil moisture dynamics, the irrigation-related recharge on soil moisture, and the DSR characteristics before and after irrigation, during the early sowing period from 2 April to 2 May 2017. Research results show that: (1 Irrigation significantly influences the soil moisture of 0–150 cm depths. The soil moisture increase after the irrigation follows the order from high to low when it is in the order of loam, sand, and clay. (2 Irrigation-induced soil moisture recharge occurs on all three soil combinations at 0–150 cm layers, and the order of soil moisture recharge from high to low

  10. Is physiotherapy effective for children with complex regional pain syndrome type 1?

    Science.gov (United States)

    Bialocerkowski, Andrea E; Daly, Anne

    2012-01-01

    This study synthesized current research evidence on the effectiveness of physiotherapy for the management of children diagnosed with complex regional pain syndrome type 1 (CRPS-1), to provide up-to-date physiotherapy treatment recommendations, and to identify areas that require further investigation. Nine electronic databases were searched for quantitative studies that evaluated the effect of physiotherapy on children with CRPS-1. The methodological quality of the studies was evaluated using the Critical Review Form. Data were extracted regarding the study design, participant characteristics, types of outcome measures used, and physiotherapy technique used and its effectiveness. The search strategy identified 303 potential studies, of which 12 met the inclusion criteria (1 randomized controlled trial, 1 comparative study, 10 case series). The methodological quality of all studies was rated as poor to fair. The "stand-alone" value of physiotherapy could not be determined as physiotherapy was prescribed in conjunction with psychological and medical interventions. There is low volume and poor-to-fair quality evidence which suggests that physiotherapy prescribed with other interventions may lead to short-term improvement in the signs and symptoms of CRPS-1 or functional ability in children with CRPS-1, and the relapse rate may be moderately high. High-quality studies are required in this area. These studies should evaluate a package of care (which includes physiotherapy); they should investigate the effects of physiotherapy treatments that have proven effectiveness in adults with CRPS-1; they should use psychometrically sound measures to evaluate outcome; and the nature of physiotherapy should be detailed in future publications to enable replication in the clinical setting.

  11. Potentials and Limitations of Regional Organic Food Supply: A Qualitative Analysis of Two Food Chain Types in the Berlin Metropolitan Region

    Directory of Open Access Journals (Sweden)

    Alexandra Doernberg

    2016-11-01

    Full Text Available Regional food systems and organic agriculture are both considered more sustainable than the conventional, globalized food system they provide an alternative to. The emergence and expansion of alternative forms of food supply are influenced by various factors on different scales. Using the food systems approach we aim to study potentials and limitations of regional organic food supply in the Berlin metropolitan region (BMR. Based on the literature, we developed an analytical framework and identified determinants of regional organic food provision along the three major levels of the supply chain: agricultural production, food chain organization, and consumption. Then, we examined a qualitative case study with two different types of alternative food networks (A organic community supported agriculture (CSA and (B organic retail trade. Factors that hinder or promote the provision of regional organic food were identified through qualitative interviews and assessed by regional stakeholders in a workshop. Our findings show that demand for regional organic food is higher than regional supply, which could offer good possibilities for organic farmers. However, actors in these two food chains need to overcome some obstacles, including limited access to land, increasing renting prices, insufficient processing capacities, and unsupportive political environment for organic farming.

  12. Sex differences in complex regional pain syndrome type I (CRPS-I) in mice.

    Science.gov (United States)

    Tang, Chaoliang; Li, Juan; Tai, Wai Lydia; Yao, Weifeng; Zhao, Bo; Hong, Junmou; Shi, Si; Wang, Song; Xia, Zhongyuan

    2017-01-01

    Sex differences have been increasingly highlighted in complex regional pain syndrome (CRPS) in clinical practice. In CRPS type I (CRPS-I), although inflammation and oxidative stress have been implicated in its pathogenesis, whether pain behavior and the underlying mechanism are sex-specific is unclear. In the present study, we sought to explore whether sex differences have an impact on inflammation, oxidative stress, and pain sensitivity in CRPS-I. Chronic post-ischemia pain (CPIP) was established in both male and female mice as an animal model of CRPS-I. Edema and mechanical allodynia of bilateral hind paws were assessed after reperfusion. Blood samples were analyzed for serum levels of oxidative stress markers and inflammatory cytokines. Both male and female mice developed edema. Male mice developed CPIP at day 3 after reperfusion; female mice developed CPIP at day 2 after reperfusion. Female mice displayed significantly earlier and higher mechanical allodynia in the ischemic hind paw, which was associated with higher serum levels of IL-2, TNF-α, isoprostanes, 8 OhdG, and malondialdehyde at day 2 after reperfusion. Moreover, female mice showed significantly lower SOD and IL-4 compared to male mice at day 2 after reperfusion. Our results indicate that sex differences in inflammatory and oxidative stress states may play a central role in the sex-specific nociceptive hypersensitivity in CRPS-I, and offer a new insight into pharmacology treatments to improve pain management with CRPS.

  13. A pet-type robot AIBO-assisted therapy as a day care program for chronic schizophrenia patients: A pilot study

    Directory of Open Access Journals (Sweden)

    Shin Narita

    2016-07-01

    Full Text Available Background AAT (Animal-assisted therapy was developed to promote human social and emotional functioning as a day care program for psychiatric patients. Aims In this study, we performed AAT using a pet-type robot, AIBO for schizophrenic patients. Methods After obtaining informed consent, we performed the AIBO-assisted therapy for three schizophrenic (ICD-10, F20.x2 patients (male: 1, female: 2 whose medication did not change over the 8 weeks study period in a ward. Results It was found that the AAT using AIBO may be useful for the patients with negative and general psychopathological symptoms such as “Anxiety” and “Uncooperativeness”. Conclusion We make use of this result, and we want to develop the AAT program using a pet-type robot, AIBO which may be suitable for Japanese psychiatric patients.

  14. Genetic characterization of UCS region of Pneumocystis jirovecii and construction of allelic profiles of Indian isolates based on sequence typing at three regions.

    Science.gov (United States)

    Gupta, Rashmi; Mirdha, Bijay Ranjan; Guleria, Randeep; Kumar, Lalit; Luthra, Kalpana; Agarwal, Sanjay Kumar; Sreenivas, Vishnubhatla

    2013-01-01

    Pneumocystis jirovecii is an opportunistic pathogen that causes severe pneumonia in immunocompromised patients. To study the genetic diversity of P. jirovecii in India the upstream conserved sequence (UCS) region of Pneumocystis genome was amplified, sequenced and genotyped from a set of respiratory specimens obtained from 50 patients with a positive result for nested mitochondrial large subunit ribosomal RNA (mtLSU rRNA) PCR during the years 2005-2008. Of these 50 cases, 45 showed a positive PCR for UCS region. Variations in the tandem repeats in UCS region were characterized by sequencing all the positive cases. Of the 45 cases, one case showed five repeats, 11 cases showed four repeats, 29 cases showed three repeats and four cases showed two repeats. By running amplified DNA from all these cases on a high-resolution gel, mixed infection was observed in 12 cases (26.7%, 12/45). Forty three of 45 cases included in this study had previously been typed at mtLSU rRNA and internal transcribed spacer (ITS) region by our group. In the present study, the genotypes at those two regions were combined with UCS repeat patterns to construct allelic profiles of 43 cases. A total of 36 allelic profiles were observed in 43 isolates indicating high genetic variability. A statistically significant association was observed between mtLSU rRNA genotype 1, ITS type Ea and UCS repeat pattern 4. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Regional variations in cancer survival: Impact of tumour stage, socioeconomic status, comorbidity and type of treatment in Norway.

    Science.gov (United States)

    Skyrud, Katrine Damgaard; Bray, Freddie; Eriksen, Morten Tandberg; Nilssen, Yngvar; Møller, Bjørn

    2016-05-01

    Cancer survival varies by place of residence, but it remains uncertain whether this reflects differences in tumour, patient and treatment characteristics (including tumour stage, indicators of socioeconomic status (SES), comorbidity and information on received surgery and radiotherapy) or possibly regional differences in the quality of delivered health care. National population-based data from the Cancer Registry of Norway were used to identify cancer patients diagnosed in 2002-2011 (n = 258,675). We investigated survival from any type of cancer (all cancer sites combined), as well as for the six most common cancers. The effect of adjusting for prognostic factors on regional variations in cancer survival was examined by calculating the mean deviation, defined by the mean absolute deviation of the relative excess risks across health services regions. For prostate cancer, the mean deviation across regions was 1.78 when adjusting for age and sex only, but decreased to 1.27 after further adjustment for tumour stage. For breast cancer, the corresponding mean deviations were 1.34 and 1.27. Additional adjustment for other prognostic factors did not materially change the regional variation in any of the other sites. Adjustment for tumour stage explained most of the regional variations in prostate cancer survival, but had little impact for other sites. Unexplained regional variations after adjusting for tumour stage, SES indicators, comorbidity and type of treatment in Norway may be related to regional inequalities in the quality of cancer care. © 2015 UICC.

  16. Developmental assistance for child and adolescent mental health in low– and middle–income countries (2007–2014): Annual trends and allocation by sector, project type, donors and recipients

    Science.gov (United States)

    Turner, Jasmine; Pigott, Hugo; Tomlinson, Mark; Jordans, Mark JD

    2017-01-01

    Background Globally, mental disorders are the leading cause of disability among children and adolescents. To date, there has been no estimate of developmental assistance supporting mental health projects that target children and adolescents (DAMH–CA). This study aimed to identify, describe and analyse DAMH–CA with respect to annual trends (2007–2014), sector, project type, recipient regions, and top donor and recipient countries, and estimate annual DAMH–CA per child/adolescent by region. Methods Developmental assistance for all projects focused on children and adolescent mental health between 2007 and 2014 was identified on the Organisation for Economic Co–operation and Development’s (OECD) Creditor Reporting System, and analysed by target population, sector, project type, donors, and recipients. The study did not include governmental or private organisation funds, nor funding for projects that targeted the community or those that included mental health but not as a primary objective. Results Between 2007 and 2014, 704 projects were identified, constituting US$ 88.35 million in DAMH–CA, with an average of 16.9% of annual development assistance for mental health. Three quarters of DAMH–CA was used to fund projects in the humanitarian sector, while less than 10% was directed at mental health projects within the education, HIV/AIDS, rights, and neurology sectors. DAMH–CA was predominantly invested in psychosocial support projects (US$ 63.24 million, 72%), while little in absolute and relative terms supported capacity building, prevention, promotion or research, with the latter receiving just US$ 1.2 million over the eight years (1.4% of total DAMH–CA). For 2014, DAMH–CA per child/adolescent was US$ 0.02 in Europe, less than US$ 0.01 in Asia, Africa, and Latin America and the Caribbean, and US$ 0 in Oceania. Conclusions To mitigate the growing burden of mental and neurological disorders, increased financial aid must be invested in child and

  17. Developmental assistance for child and adolescent mental health in low- and middle-income countries (2007-2014): Annual trends and allocation by sector, project type, donors and recipients.

    Science.gov (United States)

    Turner, Jasmine; Pigott, Hugo; Tomlinson, Mark; Jordans, Mark Jd

    2017-12-01

    Globally, mental disorders are the leading cause of disability among children and adolescents. To date, there has been no estimate of developmental assistance supporting mental health projects that target children and adolescents (DAMH-CA). This study aimed to identify, describe and analyse DAMH-CA with respect to annual trends (2007-2014), sector, project type, recipient regions, and top donor and recipient countries, and estimate annual DAMH-CA per child/adolescent by region. Developmental assistance for all projects focused on children and adolescent mental health between 2007 and 2014 was identified on the Organisation for Economic Co-operation and Development's (OECD) Creditor Reporting System, and analysed by target population, sector, project type, donors, and recipients. The study did not include governmental or private organisation funds, nor funding for projects that targeted the community or those that included mental health but not as a primary objective. Between 2007 and 2014, 704 projects were identified, constituting US$ 88.35 million in DAMH-CA, with an average of 16.9% of annual development assistance for mental health. Three quarters of DAMH-CA was used to fund projects in the humanitarian sector, while less than 10% was directed at mental health projects within the education, HIV/AIDS, rights, and neurology sectors. DAMH-CA was predominantly invested in psychosocial support projects (US$ 63.24 million, 72%), while little in absolute and relative terms supported capacity building, prevention, promotion or research, with the latter receiving just US$ 1.2 million over the eight years (1.4% of total DAMH-CA). For 2014, DAMH-CA per child/adolescent was US$ 0.02 in Europe, less than US$ 0.01 in Asia, Africa, and Latin America and the Caribbean, and US$ 0 in Oceania. To mitigate the growing burden of mental and neurological disorders, increased financial aid must be invested in child and adolescent mental health, especially with respect to capacity

  18. Assistive Devices

    Science.gov (United States)

    If you have a disability or injury, you may use a number of assistive devices. These are tools, products or types of equipment that help you perform tasks and activities. They may help you move around, see, communicate, eat, or get ...

  19. 40 CFR 35.3565 - Specific cash draw rules for authorized types of assistance from the Fund.

    Science.gov (United States)

    2010-07-01

    ... the following rules: (a) Loans—(1) Eligible project costs. A State may draw cash based on the... associated pre-project costs, cash may be drawn immediately upon execution of the loan agreement. (2) Eligible project reimbursement costs. A State may draw cash to reimburse assistance recipients for eligible...

  20. Effects of Gloss Type on Text Recall and Incidental Vocabulary Learning in Mobile-Assisted L2 Listening

    Science.gov (United States)

    Çakmak, Fidel; Erçetin, Gülcan

    2018-01-01

    This study investigates the effects of multimedia glosses on text recall and incidental vocabulary learning in a mobile-assisted L2 listening task. A total of 88 participants with a low level of proficiency in English were randomly assigned to one of four conditions that involved single channel (textual-only, pictorial-only) and dual-channel…

  1. First ultraviolet observations of the transition regions of X-ray bright solar-type stars in the Pleiades

    Science.gov (United States)

    Caillault, J.-P.; Vilhu, O.; Linsky, J. L.

    1990-01-01

    Results are reported from A UV study of the transition regions of two X-ray-bright solar-type stars from the Pleiades, in an attempt to extend the main sequence age baseline for the transition-region activity-age relation over more than two orders of magnitude. However, no emission lines were detected from either star; the upper limits to the fluxes are consistent with previously determined saturation levels, but do not help to further constrain evolutionary models.

  2. Divergence in Forest-Type Response to Climate and Weather: Evidence for Regional Links Between Forest-Type Evenness and Net Primary Productivity

    Science.gov (United States)

    Bradford, J.B.

    2011-01-01

    Climate change is altering long-term climatic conditions and increasing the magnitude of weather fluctuations. Assessing the consequences of these changes for terrestrial ecosystems requires understanding how different vegetation types respond to climate and weather. This study examined 20 years of regional-scale remotely sensed net primary productivity (NPP) in forests of the northern Lake States to identify how the relationship between NPP and climate or weather differ among forest types, and if NPP patterns are influenced by landscape-scale evenness of forest-type abundance. These results underscore the positive relationship between temperature and NPP. Importantly, these results indicate significant differences among broadly defined forest types in response to both climate and weather. Essentially all weather variables that were strongly related to annual NPP displayed significant differences among forest types, suggesting complementarity in response to environmental fluctuations. In addition, this study found that forest-type evenness (within 8 ?? 8 km2 areas) is positively related to long-term NPP mean and negatively related to NPP variability, suggesting that NPP in pixels with greater forest-type evenness is both higher and more stable through time. This is landscape- to subcontinental-scale evidence of a relationship between primary productivity and one measure of biological diversity. These results imply that anthropogenic or natural processes that influence the proportional abundance of forest types within landscapes may influence long-term productivity patterns. ?? 2011 Springer Science+Business Media, LLC (outside the USA).

  3. Composite films prepared by plasma ion-assisted deposition (IAD) for design and fabrication of antireflection coatings in visible and near-infrared spectral regions

    Science.gov (United States)

    Tsai, Rung-Ywan; Ho, Fang C.

    1994-11-01

    Ion-assisted deposition (IAD) processes configured with a well-controlled plasma source at the center base of a vacuum chamber, which accommodates two independent e-gun sources, is used to deposition TiO2MgF2 and TiO2-SiO2 composite films of selected component ratios. Films prepared by this technology are found durable, uniform, and nonabsorbing in visible and near-IR regions. Single- and multilayer antireflection coatings with refractive index from 1.38 to 2.36 at (lambda) equals 550 nm are presented. Methods of enhancement in optical performance of these coatings are studied. The advantages of AR coatings formed by TiO2-MgF2 composite films over those similar systems consisting of TiO2-SiO2 composite films in both visible and near-IR regions are also presented.

  4. Regional factors rather than forest type drive the community structure of soil living oribatid mites (Acari, Oribatida).

    Science.gov (United States)

    Erdmann, Georgia; Scheu, Stefan; Maraun, Mark

    2012-06-01

    Most European forests are managed by humans. However, the manner and intensity of management vary. While the effect of forest management on above-ground communities has been investigated in detail, effects on the below-ground fauna remain poorly understood. Oribatid mites are abundant microarthropods in forest soil and important decomposers in terrestrial ecosystems. Here, we investigated the effect of four forest types (i.e., managed coniferous forests; 30 and 70 years old managed beech forests; natural beech forests) on the density, diversity and community structure of oribatid mites (Acari). The study was replicated at three regions in Germany: the Swabian Alb, the Hainich and the Schorfheide. To relate changes in oribatid mite community structure to environmental factors, litter mass, pH, C and N content of litter, fine roots and C content of soil were measured. Density of oribatid mites was highest in the coniferous forests and decreased in the order 30 years old, 70 years old, and natural beech forests. Mass of the litter layer and density of oribatid mites were strongly correlated indicating that the litter layer is an important factor regulating oribatid mite densities. Diversity of oribatid mites was little affected by forest type indicating that they harbor similar numbers of niches. Species composition differed between the forest types, suggesting different types of niches. The community structure of oribatid mites differed more strongly between the three regions than between the forest types indicating that regional factors are more important than effects associated with forest type.

  5. Beyond «Bell Jar»: Innovative Entrepreneurship in «Resource-type» Regions of Russia

    Directory of Open Access Journals (Sweden)

    Sergey N. Levin

    2017-09-01

    Full Text Available Goals and strategies characteristics of innovative entrepreneurs’ behavior of Kemerovo Region and Krasnoyarsk Region as potential subjects of modernization of resource-type regions’ economies are highlighted in the paper. Proposed approach is based on analysis of the relationship between specifics of the institu-tional environment of the Russian economy and types of entrepreneurs. Institution-al environment of the domestic economy is characterized by three interrelated basic parameters: political-bureaucratic market and mixed regime of property rights, enclave dual economy and regionalization. Formed institutional system modifies significantly entrepreneurs’ target objectives as well as the structure of resources that are crucial for doing business and generates a variety of their types. Using matrix classification of domestic entrepreneurs built on the basis of two criteria, i.e. entrepreneurs’ prevailing motivation and degree of individual political resource using, is proposed and validated in the paper. The validity of the developed matrix classification was inductively tested on the sociological research materials of developmental institutions residents in the compared resource-type regions, i.e. Kuzbass Technopark and Krasnoyarsk Regional Innovative-Technological Busi-ness Incubator. They were chosen as a subject of research as potential actors of regions’ economy modernization operating outside of the privileged resource sec-tor "bell jar". The processing of the sociological research results was carried out using nonparametric criteria that allow working with small samples. The fulfilled analysis showed that innovative entrepreneurs’ activities follow the logic of enclave dual economy without creating any conditions for resource-type regions transition to integrated economy development path.

  6. Specific genomic regions are differentially affected by copy number alterations across distinct cancer types, in aggregated cytogenetic data.

    Science.gov (United States)

    Kumar, Nitin; Cai, Haoyang; von Mering, Christian; Baudis, Michael

    2012-01-01

    Regional genomic copy number alterations (CNA) are observed in the vast majority of cancers. Besides specifically targeting well-known, canonical oncogenes, CNAs may also play more subtle roles in terms of modulating genetic potential and broad gene expression patterns of developing tumors. Any significant differences in the overall CNA patterns between different cancer types may thus point towards specific biological mechanisms acting in those cancers. In addition, differences among CNA profiles may prove valuable for cancer classifications beyond existing annotation systems. We have analyzed molecular-cytogenetic data from 25579 tumors samples, which were classified into 160 cancer types according to the International Classification of Disease (ICD) coding system. When correcting for differences in the overall CNA frequencies between cancer types, related cancers were often found to cluster together according to similarities in their CNA profiles. Based on a randomization approach, distance measures from the cluster dendrograms were used to identify those specific genomic regions that contributed significantly to this signal. This approach identified 43 non-neutral genomic regions whose propensity for the occurrence of copy number alterations varied with the type of cancer at hand. Only a subset of these identified loci overlapped with previously implied, highly recurrent (hot-spot) cytogenetic imbalance regions. Thus, for many genomic regions, a simple null-hypothesis of independence between cancer type and relative copy number alteration frequency can be rejected. Since a subset of these regions display relatively low overall CNA frequencies, they may point towards second-tier genomic targets that are adaptively relevant but not necessarily essential for cancer development.

  7. Intravenous magnesium for chronic complex regional pain syndrome type 1 (CRPS-1).

    Science.gov (United States)

    Fischer, Sigrid G L; Collins, Susan; Boogaard, Sabine; Loer, Stephan A; Zuurmond, Wouter W A; Perez, Roberto S G M

    2013-09-01

    To assess the effects of intravenous administration of magnesium on complex regional pain syndrome type 1 (CRPS-1), a randomized double-blind placebo-controlled trial was performed. Fifty-six patients with CRPS-1 (International Association for the Study of Pain Orlando criteria) received MgSO(4) 70 mg/kg or placebo (NaCl 0.9%) in 4 hours over 5 consecutive days. Pain (BOX-11 and McGill), the level of impairment (Impairment level Sum Score [ISS]), functional limitations (Radboud Skills Questionnaire, Walking Skills Questionnaire/questionnaire rising and sitting down), participation (Impact on Participation and Autonomy [IPA]), and quality of life (Short Form-36, EuroQol, IPA) were evaluated at baseline and at 1, 3, 6, and 12 weeks. No significant differences were found between MgSO(4) and placebo on the BOX-11 and ISS at different time points during the trial on intention-to-treat and per-protocol analysis. A significant improvement on the BOX-11 was found after the first week of the trial in both groups (mean 0.7; standard deviation 1.1). For the MgSO(4) group, a clinically relevant and statistically significant improvement on the ISS at 1 week (median 5, interquartile range [IQR] -1 to 8) and a significant improvement on the McGill up to 6 weeks (median 2 words, IQR 0-4.5) were found compared with baseline, which were not found in the placebo group. Significant improvement in perceived job participation was found for the MgSO(4) group at 12 weeks (median improvement 1.44-1.17; P = 0.01). ISS improved significantly more in patients with a low Hospital Anxiety and Depression Scale (HADS) score (≤10) in the MgSO(4) group (mean 4.4 vs mean -3.1; P = 0.02). Administration of the physiological competitive N-methyl-D-aspartate receptor antagonist magnesium in chronic CRPS provides insufficient benefit over placebo. Future research should focus on patients with acute CRPS and early signs and symptoms of central sensitization. Wiley Periodicals, Inc.

  8. Seasonal differences assist in mapping granite outcrops using Landsat TM imagery across the Southwest Australian Floristic Region

    NARCIS (Netherlands)

    Alibegovic, G.; Schut, A.G.T.; Wardell-Johnson, G.W.; Robinson, T.P.

    2015-01-01

    Knowledge of the location and extent of granite outcrops (GOs) in the Southwest Australian Floristic Region is important to understand their role as refugia. We present a methodology to map GOs using biannual Landsat TM imagery. An adaptive vegetation cover mask capitalising on seasonal differences,

  9. Regional differences in islet distribution in the human pancreas--preferential beta-cell loss in the head region in patients with type 2 diabetes.

    Directory of Open Access Journals (Sweden)

    Xiaojun Wang

    Full Text Available While regional heterogeneity in islet distribution has been well studied in rodents, less is known about human pancreatic histology. To fill gaps in our understanding, regional differences in the adult human pancreas were quantitatively analyzed including the pathogenesis of type 2 diabetes (T2D. Cadaveric pancreas specimens were collected from the head, body and tail regions of each donor, including subjects with no history of diabetes or pancreatic diseases (n = 23 as well as patients with T2D (n = 12. The study further included individuals from whom islets were isolated (n = 7 to study islet yield and function in a clinical setting of islet transplantation. The whole pancreatic sections were examined using an innovative large-scale image capture and unbiased detailed quantitative analyses of the characteristics of islets from each individual (architecture, size, shape and distribution. Islet distribution/density is similar between the head and body regions, but is >2-fold higher in the tail region. In contrast to rodents, islet cellular composition and architecture were similar throughout the pancreas and there was no difference in glucose-stimulated insulin secretion in islets isolated from different regions of the pancreas. Further studies revealed preferential loss of large islets in the head region in patients with T2D. The present study has demonstrated distinct characteristics of the human pancreas, which should provide a baseline for the future studies integrating existing research in the field and helping to advance bi-directional research between humans and preclinical models.

  10. Forecasting Forest Type and Age Classes in the Appalachian-Cumberland Subregion of the Central Hardwood Region

    Science.gov (United States)

    David N. Wear; Robert Huggett

    2011-01-01

    This chapter describes how forest type and age distributions might be expected to change in the Appalachian-Cumberland portions of the Central Hardwood Region over the next 50 years. Forecasting forest conditions requires accounting for a number of biophysical and socioeconomic dynamics within an internally consistent modeling framework. We used the US Forest...

  11. Impact of spinal cord stimulation on sensory characteristics in complex regional pain syndrome type I - A randomized trial

    NARCIS (Netherlands)

    Kemler, MA; Reulen, JPH; Barendse, GAM; van Kleef, M; de Vet, HCW; van den Wildenberg, FAJM

    Background: A randomized trial was performed to assess the effect of spinal cord stimulation (SCS) on detection and pain thresholds for pressure, warmth, and cold and on the extent of mechanical hyperalgesia in patients with chronic complex regional pain syndrome type I. Methods: Fifty-four chronic

  12. Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia.

    Science.gov (United States)

    Stipancić, Gordana; La Grasta Sabolić, Lavinia; Pozgaj Sepec, Marija; Radica, Ana; Skrabić, Veselin; Severinski, Srećko; Kujundzić Tiljak, Mirjana

    2012-04-01

    To determine regional differences in the incidence, incidence trends, and clinical presentation of type 1 diabetes in children under the age of 15 years in Croatia in a 9-year period (1995-2003). We included the patients who had been diagnosed with the disease and had started the insulin treatment before they were 15 years old. Regional differences between eastern, central, and southern Croatia were observed. The gross incidence was expressed by the number of newly diagnosed type 1 diabetes patients in 100000 children of the same age and sex per year, ie, for the 0-14 age group, and for the 0-4, 5-9, and 10-14 subgroups. The highest incidence was observed in southern Croatia (10.91 per 100000/y) and the lowest in central Croatia (8.64 per 100000/y), and in eastern Croatia the incidence was 8.93 per 100000/y. All three regions showed a growing incidence trend, which was significant only in eastern and southern Croatia. There was 35.9% of patients with diabetic ketoacidosis in eastern Croatia, 41.7% in central Croatia, and 31.28% in southern Croatia. Croatian regions show differences in the incidence, incidence trends, and disease presentation of type 1 diabetes. A further follow-up is needed to establish whether the regional differences are a consequence of the population dynamics in the observed period or they will continue to exist, pointing to differences in environmental risk factors.

  13. Movement Performance of Human-Robot Cooperation Control Based on EMG-Driven Hill-Type and Proportional Models for an Ankle Power-Assist Exoskeleton Robot.

    Science.gov (United States)

    Ao, Di; Song, Rong; Gao, JinWu

    2017-08-01

    Although the merits of electromyography (EMG)-based control of powered assistive systems have been certified, the factors that affect the performance of EMG-based human-robot cooperation, which are very important, have received little attention. This study investigates whether a more physiologically appropriate model could improve the performance of human-robot cooperation control for an ankle power-assist exoskeleton robot. To achieve the goal, an EMG-driven Hill-type neuromusculoskeletal model (HNM) and a linear proportional model (LPM) were developed and calibrated through maximum isometric voluntary dorsiflexion (MIVD). The two control models could estimate the real-time ankle joint torque, and HNM is more accurate and can account for the change of the joint angle and muscle dynamics. Then, eight healthy volunteers were recruited to wear the ankle exoskeleton robot and complete a series of sinusoidal tracking tasks in the vertical plane. With the various levels of assist based on the two calibrated models, the subjects were instructed to track the target displayed on the screen as accurately as possible by performing ankle dorsiflexion and plantarflexion. Two measurements, the root mean square error (RMSE) and root mean square jerk (RMSJ), were derived from the assistant torque and kinematic signals to characterize the movement performances, whereas the amplitudes of the recorded EMG signals from the tibialis anterior (TA) and the gastrocnemius (GAS) were obtained to reflect the muscular efforts. The results demonstrated that the muscular effort and smoothness of tracking movements decreased with an increase in the assistant ratio. Compared with LPM, subjects made lower physical efforts and generated smoother movements when using HNM, which implied that a more physiologically appropriate model could enable more natural and human-like human-robot cooperation and has potential value for improvement of human-exoskeleton interaction in future applications.

  14. Kinematic model of some types of motion of matter in active regions

    International Nuclear Information System (INIS)

    Platov, Yu.V.

    1983-01-01

    The kinematics of matter motion in variable magnetic fields of active regions on the Sun in the MHD approximation of a strong field and cold plasma is investigated. It is shown that the variation of sunspot magnetic moments lead to the development of different active phenomena in the solar atmosphere. The development of such phenomena at first can occur at the phase of active region growth, when new sunspots together with developed sunspots emerge in an active region or relative motions take place in a sunspot group

  15. Complex Regional Pain Syndrome (CRPS Type II After Carpal Tunnel Release Surgery: Case Report

    Directory of Open Access Journals (Sweden)

    Hakan Tunç

    2010-08-01

    Full Text Available Summary Complex regional pain syndrome is a chronic syndrome characterised with dystrophic changes and neurovascular disordes of bone and skin of extremities. The most common etiological factors are trauma, ischemic heart disease, cerebral lesions, servical region disorders, infections, and surgical treatments. Carpal tunnel syndrome is the most common compressive neuropaty of the upper extremity. There are various surgical and conservative alternatives in the treatment of carpal tunnel syndrome. Complex regional pain syndrome has been reported as a complication of surgical carpal tunnel release in 2-5% of patients. In this case report clinical characteristics and rehabilitation outcomes of a patient with complex regional pain syndrome after carpal tunnel release surgery is presented. (Osteoporoz Dünyasından 2010;16:41-3

  16. Relationships of mercury concentrations across tissue types, muscle regions and fins for two shark species

    KAUST Repository

    O'Bryhim, Jason R.; Adams, Douglas H.; Spaet, Julia L.; Mills, Gary; Lance, Stacey L.

    2017-01-01

    mercury (THg) concentrations from eight muscle regions, four fins (first dorsal, left and right pectorals, caudal-from both the inner core and trailing margin of each fin), and five internal organs (liver, kidney, spleen, heart, epigonal organ) from two

  17. Type and characteristics of the regional products from West Yorkshire UK

    Directory of Open Access Journals (Sweden)

    Maria Grzybek

    2010-01-01

    Full Text Available The article presents the results of studies conducted among 200 British consumers who examined the characteristics of regional products, from West Yorkshire in the UK. The opinion showed that the highest scores obtained freshness and flavour of these goods. The appearance and packing of these products were evaluated at a good level. Consumers turned their attention to relatively high prices offered to regional products. They critically commented on the advertising campaigns that affect the growth of demand.

  18. Blue-green ZnSe lasers with a new type of active region

    International Nuclear Information System (INIS)

    Ivanov, S.V.; Toropov, A.A.; Sorokin, S.V.; Shubina, T.V.; Sedova, I.V.; Kop'ev, P.S.; Alferov, Zh.I.; Waag, A.; Lugauer, H.J.; Reuscher, G.; Keim, M.; Fischer, F.F.; Landwehr, G.

    1999-01-01

    We report the results of an experimental study of molecular-beam epitaxy of ZnSe-based laser heterostructures with a new structure of the active region, which contains a fractional-monolayer CdSe recombination region in an expanded ZnSe quantum well and a waveguide based on a variably-strained, short-period superlattice are reported. Growth of a fractional-monolayer CdSe region with a nominal thickness of 2-3 ML, i.e., less than the critical thickness, on a ZnSe surface (Δa/a∼7%) leads to the formation of self-organized, pseudomorphic, CdSe-enriched islands with lateral dimensions ∼10-30 nm and density ∼2x10 10 cm -2 , which serve as efficient centers of carrier localization, giving rise to effective spatial separation of defective regions and regions of radiative recombination and, as a result, a higher quantum efficiency. Laser structures for optical pumping in the (Zn, Mg) (S, Se) system with a record-low threshold power density (less than 4 kW/cm 2 at 300 K) and continuous-wave laser diodes in the system (Be, Mg, Zn) Se with a 2.5 to 2.8-ML-thick, fractional-monolayer CdSe active region have been obtained. The laser structures and diodes have an improved degradation resistance

  19. Geodynamic models assist in determining the South Loyalty Basin's slab location and its implications for regional topography

    Science.gov (United States)

    Clark, Stuart R.

    2010-05-01

    In the Western Pacific, two competing kinematic reconstructions exist: one with wholly westward subduction of the Pacific plate at what is now the Tonga-Kermadec trench and one combining a degree of eastward subduction under what has been termed the New Caledonia trench. New seismological observations indicate that eastward subduction could explain the existence of a fast anomaly, the hyothesised South Loyalty Basin slab, below the 660km transition zone distinct from the fast anomaly aligned with the Tonga-Kermadec slab. A plate reconstruction dated from the suggested initiation of New Caledonia subduction in the Eocene has been developed. This reconstruction is then used to predict the thermal history of the region and together provide kinematic and thermal boundary conditions for a regional mantle convection model. The model-predicted location of the South Loyalty Basin slab's location will be presented along with the location's dependence on the mantle rheological parameters and the hotspot reference frame. The implications for the topography of the region will also be discussed.

  20. Relationship between regional cerebral perfusion and cognitive disorders in type 2 diabetes mellitus

    International Nuclear Information System (INIS)

    Zhao Jinhua; Zhao Peiqin; Zhao Yan; Liu Fuyuan; Meng Juanjuan; Chen Huidong

    2001-01-01

    Objective: To investigate the characteristic rCBF abnormalities and the relationship between rCBF and cognitive disorders in type 2 diabetes mellitus patients. Methods: The study subjects were 11 middle aged, glycemic controlled type 2 diabetes mellitus patients. Age range of type 2 diabetes mellitus patients was 46 - 59 years. Eleven age-, sex-, education- and occupation- matched normal controls (age range 41 - 58 years) were studied under identical conditions. Cognitive functions were evaluated by Wechsler Memory Scale (WMS), Trail Marking Test A and Wisconsin Card Sorting Test (WCST), respectively. 99 Tc m -ECD (ethyl-cysteine ate dimer) SPECT imaging was performed on all patients and normal controls. Results: 1) Cognitive test scores of type 2 diabetes mellitus patients were lower than that of normal controls. Diabetic patients were scored lower in memory test than controls (accumulation adding, visual recognition, learning and total memory quotient of WMS, P < 0.05). Type 2 diabetes mellitus patients needed much more time to complete the trail marking test (74.2 s vs. 48.7 s). WCST scores were significantly different between two groups. 2) The rCBF values of frontal, temporal and parietal lobe were decreased significantly in type 2 diabetes mellitus patients. 3) For type 2 diabetes mellitus patients, there was a correlation between rCBF values of right frontal lobe and adding, understanding scores of WMS (positively correlated), preservative errors(%) of WCST (negatively correlated). The rCBF values of right temporal lobe were positively correlated with inverted counting. Conclusions: 1) Impairments of central nervous system are existed in glycemic controlled (lack of repeated hypoglycemia) type 2 diabetes mellitus patients. Abnormalities in CNS can express as cognitive dysfunction, such as decrement of memory, attention, thinking and conceptual reasoning abilities. 2) Hypo-perfusions of frontal, temporal and parietal cortex can be identified in patients of

  1. On the constitutive law of environment assisted fatigue: The physical meaning of the Paris type equations. Pt. 1

    International Nuclear Information System (INIS)

    Krausz, K.; Wu Xijia; Krausz, A.S.; Lian Zhiwen

    1992-01-01

    Environment assisted fatigue crack growth is a complex of thermally activated processes. Accordingly, the framework for the expression of rational constitutive law is developed from fracture kinetics theory. The correlation of the constitutive law with the Paris equation is discussed and the empirical parameters in the Paris equation are expressed explicitly in terms of activation energy, stress intensity factor range, temperature, stress ratio, and other physically rigorous engineering quantities. The theory assures and facilitates, the rigorous quantitative evaluation of the effects of the microstructure: the constitutive law gives guidance to its measurement and expresses it in terms of energy-related quantities. (orig.) [de

  2. Response of runoff and soil loss to reforestation and rainfall type in red soil region of southern China.

    Science.gov (United States)

    Huang, Zhigang; Ouyang, Zhiyun; Li, Fengrui; Zheng, Hua; Wang, Xiaoke

    2010-01-01

    To evaluate the long-term effects of reforestation types on soil erosion on degraded land, vegetation and soil properties under conventional sloping farmland (CSF) and three different reforestation types including a Pinus massoniana secondary forest (PSF), an Eucommia ulmoides artificial economic forest (EEF) and a natural succession type forest (NST), were investigated at runoff plot scale over a six-year period in a red soil region of southern China. One hundred and thirty erosive rainfall events generating runoff in plots were grouped into four rainfall types by means of K-mean clustering method. Erosive rainfall type I is the dominant rainfall type. The amount of runoff and the soil loss under erosive rainfall type III were the most, followed by rain-fall type II, IV and I. Compared with CSF treatment, reforestation treatments decreased the average annual runoff depth and the soil loss by 25.5%-61.8% and 93.9%-96.2% during the study period respectively. Meanwhile, runoff depth at PSF and EEF treatments was significantly lower than that in NST treatment, but no significant difference existed in soil erosion modulus among the three reforestation treatments. This is mainly due to the improved vegetation properties (i.e., vegetation coverage, biomass of above- and below-ground and litter-fall mass) and soil properties (i.e., bulk density, total porosity, infiltration rate and organic carbon content) in the three reforestation treatments compared to CSF treatment. The PSF and EEF are recommended as the preferred reforestation types to control runoff and soil erosion in the red soil region of southern China, with the NST potentially being used as an important supplement.

  3. Effects of regionally applied heating on the respiration of wild type ...

    African Journals Online (AJOL)

    Nocturnal dark respiration (Rn) in wild type and transgenic soybean plants ... Illinois, USA under ambient and elevated CO2 conditions was examined in this study. ... Experimental plants were transferred to a controlled growth chamber at V4 ...

  4. Type of aphasia and regional cerebral blood flow. A study with /sup 133/Xe inhalation method

    Energy Technology Data Exchange (ETDEWEB)

    Tagawa, Koichi; Sugimoto, Keiko; Minematsu, Kazuo; Yamaguchi, Takenori; Naritomi, Hiroaki; Sawada, Tohru (National Cardiovascular Center, Suita, Osaka (Japan))

    1982-11-01

    In 40 patients with aphasia due to cerebral infarction, regional cerebral blood flow (rCBF) was measured after 2 months of ictus with /sup 133/Xe inhalation method. There were 18 cases with motor aphasia and 22 with sensory aphasia. On the measurements of rCBF, 3 detectors were placed over frontal region (group F), 3 over temporal region (group T), and remaining 3 over parietal region (group P), of the dominant hemisphere. The flow values were compared with the rCBF values obtained from 21 control subjects who had no abnormality in CT scan and on neurological examinations. The control subjects revealed the hyperfrontal pattern of flow distribution; rCBF values in groups F, T and P, which were expressed as an initial slope index, were 50.0 +- 4.8, 48.0 +- 5.1 and 47.4 +- 4.5, respectively. The hyperfrontal pattern was absent in cases with motor aphasia. In this group, rCBF in groups F, T and P were 42.0 +- 8.3, 44.7 +- 8.4 and 41.0 +- 8.5, respectively, and rCBF in frontal region was significantly reduced compared with that in the control group. In sensory aphasia, rCBF values in groups F, T and P were all significantly reduced compared to the controls showing 44.0 +- 5.7, 42.8 +- 5.1 and 40.6 +- 5.4, respectively. In this group, the hyperfrontal pattern was maintained at a low flow level. When absolute rCBF values were compared between motor and sensory aphasia, there was no significant difference between these 2 groups. However, regional flow distribution in motor aphasia was significantly different from that of sensory aphasia, and the cases having the lowest value in group F were more frequently found in the former than in the latter.

  5. Expert system for assisting the repair operations on the control racks of the control rods assembly in a 900 MW PWR type reactor

    International Nuclear Information System (INIS)

    Monnier, B.; Doutre, J.L.; Franco, A.

    1990-01-01

    The expert system presented was developed for assisting the repair operations on the control equipment of the control rod assembly in a PWR type reactor. The expert system allows the representation of expert knowledge and diagnostic reasoning. The objective of the expert system is to achieve the most precise diagnostic and localizing of the breakdown elements, by processing the data acquired during breakdown. The development steps, the structure and the applications of the expert system are summarized. The expert system operates in an IBM PC equipped with a AMAIA 8 Mo card. A time schedule of 18 months is predicted [fr

  6. The relative contribution of synoptic types to rainfall over the Cape south coast region

    CSIR Research Space (South Africa)

    Engelbrecht, CJ

    2013-09-01

    Full Text Available independently identified. During 1979-2011, 179 COL events (286 COL days) were associated with rainfall over the study region. COL induced rainfall over the study region is mostly associated with COLs located over the southwestern interior (Fig. 2). Fig.../h (following Favre et al., 2012). The tracking procedure is developed in such a manner that geopotential minimums can only be employed in one track (one potential COL event). All these potential COL events are then subjected to a cold-core test...

  7. The Regional Healthcare Ecosystem Analyst (RHEA): a simulation modeling tool to assist infectious disease control in a health system.

    Science.gov (United States)

    Lee, Bruce Y; Wong, Kim F; Bartsch, Sarah M; Yilmaz, S Levent; Avery, Taliser R; Brown, Shawn T; Song, Yeohan; Singh, Ashima; Kim, Diane S; Huang, Susan S

    2013-06-01

    As healthcare systems continue to expand and interconnect with each other through patient sharing, administrators, policy makers, infection control specialists, and other decision makers may have to take account of the entire healthcare 'ecosystem' in infection control. We developed a software tool, the Regional Healthcare Ecosystem Analyst (RHEA), that can accept user-inputted data to rapidly create a detailed agent-based simulation model (ABM) of the healthcare ecosystem (ie, all healthcare facilities, their adjoining community, and patient flow among the facilities) of any region to better understand the spread and control of infectious diseases. To demonstrate RHEA's capabilities, we fed extensive data from Orange County, California, USA, into RHEA to create an ABM of a healthcare ecosystem and simulate the spread and control of methicillin-resistant Staphylococcus aureus. Various experiments explored the effects of changing different parameters (eg, degree of transmission, length of stay, and bed capacity). Our model emphasizes how individual healthcare facilities are components of integrated and dynamic networks connected via patient movement and how occurrences in one healthcare facility may affect many other healthcare facilities. A decision maker can utilize RHEA to generate a detailed ABM of any healthcare system of interest, which in turn can serve as a virtual laboratory to test different policies and interventions.

  8. The Enhancement of Regional Disaster Management Agencies (BPBD of Sumbawa Regency’s Capability in Flash Flood Management Through Aid Assistance of Japan International Cooperation Agency (JICA

    Directory of Open Access Journals (Sweden)

    Nudia Vebina Ayumahani

    2018-03-01

    Full Text Available The need for enhancing capability has a very important significance in effective disaster management activities. Regional Disaster Management Agencies (BPBD of Sumbawa Regency established cooperation with the Japan International Cooperation Agency (JICA in enhancing the capability of flash flood management. The purpose of this research was to review and evaluate the JICA’s aid assistance programs toward BPBD of Sumbawa Regency, hereafter analyze the impact of the programs. Evaluation and analysis of this research were measured by three indicators of capability which is resources, leadership and policy implementation. This research used a qualitative descriptive method and proceed through the source and method triangulation. The researcher used purposive sampling technique in choosing seven informants from BPBD of Sumbawa Regency’s staff. The results showed that JICA’s aid assistance programs towards BPBD of Sumbawa Regency had been achieved by the targets and goals that have been determined. This program has impacted on enhancing the capability of resources that leads to the ability in Mapping, Technical Guidelines (JUKNIS and Disaster Management Plan (RPB. Increasing the capability of Human Resources (HR gives the effect of increasing capability in other fields such as financial resource capability, technical resource capability, leadership capability and policy implementation capability. The main factors in the success of the capability enhancement are the discipline factor of BPBD staff, high willingness to improve capability by BPBD staff, capability- enhancing programs, and clear direction from JICA.

  9. MRI-guided procedures in various regions of the body using a robotic assistance system in a closed-bore scanner: preliminary clinical experience and limitations.

    Science.gov (United States)

    Moche, Michael; Zajonz, Dirk; Kahn, Thomas; Busse, Harald

    2010-04-01

    To present the clinical setup and workflow of a robotic assistance system for image-guided interventions in a conventional magnetic resonance imaging (MRI) environment and to report our preliminary clinical experience with percutaneous biopsies in various body regions. The MR-compatible, servo-pneumatically driven, robotic device (Innomotion) fits into the 60-cm bore of a standard MR scanner. The needle placement (n = 25) accuracy was estimated by measuring the 3D deviation between needle tip and prescribed target point in a phantom. Percutaneous biopsies in six patients and different body regions were planned by graphically selecting entry and target points on intraoperatively acquired roadmap MR data. For insertion depths between 29 and 95 mm, the average 3D needle deviation was 2.2 +/- 0.7 mm (range 0.9-3.8 mm). Patients with a body mass index of up to approximately 30 kg/m(2) fitted into the bore with the device. Clinical work steps and limitations are reported for the various applications. All biopsies were diagnostic and could be completed without any major complications. Median planning and intervention times were 25 (range 20-36) and 44 (36-68) minutes, respectively. Preliminary clinical results in a standard MRI environment suggest that the presented robotic device provides accurate guidance for percutaneous procedures in various body regions. Shorter procedure times may be achievable by optimizing technical and workflow aspects. (c) 2010 Wiley-Liss, Inc.

  10. Muscle Hyperalgesia Correlates With Motor Function in Complex Regional Pain Syndrome Type 1

    NARCIS (Netherlands)

    van Rooijen, Diana E.; Marinus, Johan; Schouten, Alfred Christiaan; Noldus, Lucas P.J.J.; van Hilten, Jacobus J.

    2013-01-01

    At present it is unclear if disturbed sensory processing plays a role in the development of the commonly observed motor impairments in patients with complex regional pain syndrome (CRPS). This study aims to investigate the relation between sensory and motor functioning in CRPS patients with and

  11. Cognitive profiles and regional cerebral blood flow patterns in dementia of the Alzheimer type

    DEFF Research Database (Denmark)

    Waldemar, G; Bruhn, P; Schmidt, E

    1994-01-01

    Individual cognitive profiles and correlations between cognitive functions and regional cerebral blood flow (rCBF) were analyzed in 20 consecutive patients with a clinical diagnosis of probable Alzheimer's disease (AD). CBF was measured with high resolution single photon emission computed...

  12. Type-2 diabetes mellitus reduces cortical thickness and decreases oxidative metabolism in sensorimotor regions after stroke.

    Science.gov (United States)

    Ferris, Jennifer K; Peters, Sue; Brown, Katlyn E; Tourigny, Katherine; Boyd, Lara A

    2018-05-01

    Individuals with type-2 diabetes mellitus experience poor motor outcomes after ischemic stroke. Recent research suggests that type-2 diabetes adversely impacts neuronal integrity and function, yet little work has considered how these neuronal changes affect sensorimotor outcomes after stroke. Here, we considered how type-2 diabetes impacted the structural and metabolic function of the sensorimotor cortex after stroke using volumetric magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). We hypothesized that the combination of chronic stroke and type-2 diabetes would negatively impact the integrity of sensorimotor cortex as compared to individuals with chronic stroke alone. Compared to stroke alone, individuals with stroke and diabetes had lower cortical thickness bilaterally in the primary somatosensory cortex, and primary and secondary motor cortices. Individuals with stroke and diabetes also showed reduced creatine levels bilaterally in the sensorimotor cortex. Contralesional primary and secondary motor cortex thicknesses were negatively related to sensorimotor outcomes in the paretic upper-limb in the stroke and diabetes group such that those with thinner primary and secondary motor cortices had better motor function. These data suggest that type-2 diabetes alters cerebral energy metabolism, and is associated with thinning of sensorimotor cortex after stroke. These factors may influence motor outcomes after stroke.

  13. The generation of a lower threshold multiwavelength fiber laser in the L-band region assisted by a Sagnac loop mirror

    International Nuclear Information System (INIS)

    Aziz, Siti Narimah; Arsad, Norhana; Bakar, Ahmad Ashrif Abu; Elias, Sayidatul Nadia; Menon, P Sushita; Shaari, Sahbudin

    2015-01-01

    A low threshold multiwavelength laser generated with the assistance of a Sagnac loop mirror is proposed. Two simple ring cavity designs are studied, namely a standard design ring cavity (design A) and a ring cavity with a Sagnac loop mirror (design B). Design B, which integrates a Sagnac loop mirror together with a polarization controller, exhibits the most optimum performance, generating seven lasing modes. Using only a 40 mW pump power from the erbium-doped fiber amplifier (EDFA), design B is the preferred ring cavity design, as it successfully produces seven lasing modes simultaneously within a 0.42 nm channel spacing in the L-band region. The ring cavity is characterized by investigating the lasing threshold through the tuning output power of the EDFA, the percentages of extracted power and cavity loss. (paper)

  14. Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats

    International Nuclear Information System (INIS)

    Kane, W.H.; Ichinose, A.; Hagen, F.S.; Davie, E.W.

    1987-01-01

    Human factor V is a high molecular weight plasma glycoprotein that participates as a cofactor in the conversion of prothrombin to thrombin by factor X/sub a/. Prior to its participation in the coagulation cascade, factor V is converted to factor V/sub a/ by thrombin generating a heavy chain and a light chain, and these two chains are held together by calcium ions. A connecting region originally located between the heavy and light chains is liberated during the activation reaction. In a previous study, a cDNA of 2970 nucleotides that codes for the carboxyl-terminal 938 amino acids of factor V was isolated and characterized from a Hep G2 cDNA library. This cDNA has been used to obtain additional clones from Hep G2 and human liver cDNA libraries. Furthermore, a Hep G2 cDNA library prepared with an oligonucleotide from the 5' end of these cDNAs was screened to obtain overlapping cDNA clones that code for the amino-terminal region of the molecule. The composite sequence of these clones spans 6911 nucleotides and is consistent with the size of the factor V message present in Hep G2 cells (approximately 7 kilobases). The cDNA codes for a leader sequence of 28 amino acids and a mature protein of 2196 amino acids. The amino acid sequence predicted from the cDNA was in complete agreement with 139 amino acid residues that were identified by Edman degradation of cyanogen bromide peptides isolated from the heavy chain region and connecting region of plasma factor V. The domain structure of human factor V is similar to that previously reported for human coagulation factor VIII. Two types of tandem repeats (17 and 9 amino acids) have also been identified in the connecting region of factor V. The present data indicate that the amino acid sequence in the heavy and light chain regions of factor V is ∼ 40% identical with the corresponding regions of factor VIII

  15. Bacterial CRISPR Regions: General Features and their Potential for Epidemiological Molecular Typing Studies.

    Science.gov (United States)

    Karimi, Zahra; Ahmadi, Ali; Najafi, Ali; Ranjbar, Reza

    2018-01-01

    CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) loci as novel and applicable regions in prokaryotic genomes have gained great attraction in the post genomics era. These unique regions are diverse in number and sequence composition in different pathogenic bacteria and thereby can be a suitable candidate for molecular epidemiology and genotyping studies. Results:Furthermore, the arrayed structure of CRISPR loci (several unique repeats spaced with the variable sequence) and associated cas genes act as an active prokaryotic immune system against viral replication and conjugative elements. This property can be used as a tool for RNA editing in bioengineering studies. The aim of this review was to survey some details about the history, nature, and potential applications of CRISPR arrays in both genetic engineering and bacterial genotyping studies.

  16. SPATIAL ANALYSIS OF A DIALECT WORD-FORMATIONAL TYPE FUNCTIONING ON THE TERRITORY OF SMOLENSK REGION

    Directory of Open Access Journals (Sweden)

    T. V. Vatlina

    2015-01-01

    Full Text Available This article is devoted to the practical application of a cartographical method in the study of a dialect word-formation based on GIS-technologies. The research has proved the importance of lingvogeographical information for the study the specificity of a dialect word-formational type.

  17. Chromosome region 2p25 is linked and associated with type 1 ...

    Indian Academy of Sciences (India)

    Type 1 diabetes (T1D) is a heterogeneous disorder which in- volves both genetic and ... 1) started treatment along with diet for the first two years; for the following three years she ... was over 0.85 at different recombination fractions. These re-.

  18. Synteny in toxigenic Fusarium species: the fumonisin gene cluster and the mating type region as examples

    NARCIS (Netherlands)

    Waalwijk, C.; Lee, van der T.A.J.; Vries, de P.M.; Hesselink, T.; Arts, J.; Kema, G.H.J.

    2004-01-01

    A comparative genomic approach was used to study the mating type locus and the gene cluster involved in toxin production ( fumonisin) in Fusarium proliferatum, a pathogen with a wide host range and a complex toxin profile. A BAC library, generated from F. proliferatum isolate ITEM 2287, was used to

  19. TprK gene regions are not suitable for epidemiological syphilis typing

    NARCIS (Netherlands)

    Heymans, R.; Kolader, M.-E.; van der Helm, J. J.; Coutinho, R. A.; Bruisten, S. M.

    2009-01-01

    Given reports of increasing syphilis incidence in Western countries, we used molecular typing and epidemiological data to elucidate Treponema pallidum transmission networks. Samples and data were collected, dating from 2002 to 2005, from a well-defined population of patients with an ulcus and a

  20. The chaotic region of Lorenz-type system in the parametric space

    International Nuclear Information System (INIS)

    Liao Haohui; Zhou Tianshou; Tang Yun

    2004-01-01

    A Lorenz-type system is introduced in this paper. The system contains as special cases the Lorenz system, Chen system and Lue system. The distribution of chaos of the system in the parametric space is numerically investigated. At the same time a set of conditions for possible existence of chaos are given, which guideline the range of searching chaos in the numerical simulation

  1. Volume distribution in saw-timber types in the ponderosa pine region.

    Science.gov (United States)

    Stephen N. Wyckoff

    1939-01-01

    The forest survey, a Nation-wide project authorized by Congress in 1928, consists of a complete and detailed investigation of the country's present and future forest resources in five major parts: (1) an inventory of the country's existing forest resources in terms of areas occupied by forest-cover types and of timber volumes, by species, in board feet and...

  2. Proximo-distal organization and fibre type regionalization in rat hindlimb muscles

    NARCIS (Netherlands)

    Wang, LC; Kernell, D

    Five muscles of the rat's lower hindlimb were compared with regard to their histochemical fibre type distribution at seven different proximo-distal levels. The muscles were: extensor digitorum longus (ED), flexor digitorum and hallucis longus (FD), gastrocnemius medialis (GM), peroneus longus (PE)

  3. Thermal simulation of different construction types in six climatic regions on heating and cooling loads

    CSIR Research Space (South Africa)

    Kumirai, T

    2012-10-01

    Full Text Available reduces its heating and cooling loads the most. 3. Applying both roof and ceiling insulation should always be avoided. 4. Building insulation is an effective intervention in all climatic regions. 5. Slightly increasing the thermal mass of a wall... were designed to evaluate the following: ? Case A ? base case ? Case B ? insulated walls ? Case C ? insulated walls and insulated ceiling ? Case D ? insulated walls, insulated ceiling and roof ? Case E ? increased thermal mass wall and insulated...

  4. Distinctive tomographic abnormalities of the craniocervical region in a patient with osteogenesis imperfecta type IV B

    International Nuclear Information System (INIS)

    Kaissi, Ali Al; Klaushofer, Klaus; Grill, Franz

    2010-01-01

    Osteogenesis imperfecta is a clinically and genetically heterogeneous group of heritable disorders of connective tissue characterized by reduced bone mass (osteopenia) with associated bone fragility. The resulting skeletal manifestations are due to a generalized deficiency in the development of both membranous and endochondral bone and include markedly thin calvarium with delayed closure of the fontanelles and the sutures and excessive Wormian bone formation. Sillence et al. developed a classification system of OI subtypes: OI type I, which is characterised by blue sclerae; perinatal lethal OI type II, also known as congenital OI; OI type III, a progressively deforming subtype with normal sclera; and OI type IV, which is characterized by a normal sclera. Levin et al. have suggested that OI subtypes could be further divided into type A and B based on the absence or presence of dentinogenesis imperfecta. Basilar impression involves the upward (vertical) migration of the odontoid process into the foramen magnum with a depression in the cranium. Basilar impression is a developmental defect and refers to the infolding of the occipital condyles, an elevation of the clivus, and the posterior cranial fossa of the skull. The soft bones of the skull base allow for progressive infolding of the dysplastic clivus and translocation of the odontoid into the posterior fossa. The combination of platybasia and basilar impression can lead to severe distortion of the spinal cord and the anterior brain stem. The specific structures that can be involved include the upper cervical cord, medulla, pons, mid-brain, cerebellum, as well as the vertebrobasilar system. (author)

  5. Distinctive tomographic abnormalities of the craniocervical region in a patient with osteogenesis imperfecta type IV B

    Energy Technology Data Exchange (ETDEWEB)

    Kaissi, Ali Al; Klaushofer, Klaus, E-mail: ali.alkaissi@osteologie.a [Ludwig Boltzmann Institute of Osteology, Vienna (Austria); Grill, Franz [Orthopaedic Hospital of Speising, Vienna (Austria). Paediatric Dept.

    2010-07-01

    Osteogenesis imperfecta is a clinically and genetically heterogeneous group of heritable disorders of connective tissue characterized by reduced bone mass (osteopenia) with associated bone fragility. The resulting skeletal manifestations are due to a generalized deficiency in the development of both membranous and endochondral bone and include markedly thin calvarium with delayed closure of the fontanelles and the sutures and excessive Wormian bone formation. Sillence et al. developed a classification system of OI subtypes: OI type I, which is characterised by blue sclerae; perinatal lethal OI type II, also known as congenital OI; OI type III, a progressively deforming subtype with normal sclera; and OI type IV, which is characterized by a normal sclera. Levin et al. have suggested that OI subtypes could be further divided into type A and B based on the absence or presence of dentinogenesis imperfecta. Basilar impression involves the upward (vertical) migration of the odontoid process into the foramen magnum with a depression in the cranium. Basilar impression is a developmental defect and refers to the infolding of the occipital condyles, an elevation of the clivus, and the posterior cranial fossa of the skull. The soft bones of the skull base allow for progressive infolding of the dysplastic clivus and translocation of the odontoid into the posterior fossa. The combination of platybasia and basilar impression can lead to severe distortion of the spinal cord and the anterior brain stem. The specific structures that can be involved include the upper cervical cord, medulla, pons, mid-brain, cerebellum, as well as the vertebrobasilar system. (author)

  6. Carrier concentration dependence of donor activation energy in n-type GaN epilayers grown on Si (1 1 1) by plasma-assisted MBE

    International Nuclear Information System (INIS)

    Kumar, Mahesh; Bhat, Thirumaleshwara N.; Roul, Basanta; Rajpalke, Mohana K.; Kalghatgi, A.T.; Krupanidhi, S.B.

    2012-01-01

    Highlights: ► The n-type GaN layers were grown by plasma-assisted molecular beam epitaxy. ► The optical characteristics of a donor level in Si-doped GaN were studied. ► Activation energy of a Si-related donor was estimated from temperature dependent PL measurements. ► PL peak positions, FWHM of PL and activation energies are found to be proportional to the cube root of carrier density. ► The involvement of donor levels is supported by the temperature-dependent electron concentration measurements. -- Abstract: The n-type GaN layers were grown by plasma-assisted MBE and either intentionally doped with Si or unintentionally doped. The optical characteristics of a donor level in Si-doped, GaN were studied in terms of photoluminescence (PL) spectroscopy as a function of electron concentration. Temperature dependent PL measurements allowed us to estimate the activation energy of a Si-related donor from temperature-induced decay of PL intensity. PL peak positions, full width at half maximum of PL and activation energies are found to be proportional to the cube root of carrier density. The involvement of donor levels is supported by the temperature-dependent electron concentration measurements.

  7. Ultrasensitive Faraday cage-type electrochemiluminescence assay for femtomolar miRNA-141 via graphene oxide and hybridization chain reaction-assisted cascade amplification.

    Science.gov (United States)

    Lu, Jing; Wu, Lin; Hu, Yufang; Wang, Sui; Guo, Zhiyong

    2018-06-30

    In this study, a novel electrochemiluminescence (ECL) biosensor for sensitive detection of femtomolar miRNA-141 was constructed on the basis of Faraday cage-type strategy via graphene oxide (GO) and hybridization chain reaction (HCR)-assisted cascade amplification. A capture probe (CP) was immobilized on Fe 3 O 4 @SiO 2 @Au nanoparticles as capture unit, which could catch the miRNA-141, and the immobilization of the signal unit (Ru(phen) 3 2+ -HCR/GO) was allowed via nucleic acid hybridization. The prepared biosensor exhibited two advantages for signal amplification: firstly, GO could lap on the electrode surface directly, extending Outer Helmholtz Plane (OHP) of the sensor due to the large surface area and good electronic transport property; secondly, HCR-assisted cascade amplification was designed by anchoring all HCR products on the GO surface, then embedding Ru(phen) 3 2+ as a signal readout pathway. All these signal molecules could take part in electrochemical reactions, thus further enhancing the ECL signal drastically. Therefore, the proposed sensor constructed by integrating HCR with Faraday cage-type strategy displayed an ultrasensitive detection platform for the miRNA-141 with a low detection limit of 0.03 fM. In addition, this proposed biosensor provides a universal platform for analysis of other microRNAs. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. The Successful Diagnosis and Typing of Systemic Amyloidosis Using A Microwave-Assisted Filter-Aided Fast Sample Preparation Method and LC/MS/MS Analysis.

    Directory of Open Access Journals (Sweden)

    Weiyi Sun

    Full Text Available Laser microdissection followed by mass spectrometry has been successfully used for amyloid typing. However, sample contamination can interfere with proteomic analysis, and overnight digestion limits the analytical throughput. Moreover, current quantitative analysis methods are based on the spectrum count, which ignores differences in protein length and may lead to misdiagnoses. Here, we developed a microwave-assisted filter-aided sample preparation (maFASP method that can efficiently remove contaminants with a 10-kDa cutoff ultrafiltration unit and can accelerate the digestion process with the assistance of a microwave. Additionally, two parameters (P- and D-scores based on the exponentially modified protein abundance index were developed to define the existence of amyloid deposits and those causative proteins with the greatest abundance. Using our protocol, twenty cases of systemic amyloidosis that were well-typed according to clinical diagnostic standards (training group and another twenty-four cases without subtype diagnoses (validation group were analyzed. Using this approach, sample preparation could be completed within four hours. We successfully subtyped 100% of the cases in the training group, and the diagnostic success rate in the validation group was 91.7%. This maFASP-aided proteomic protocol represents an efficient approach for amyloid diagnosis and subtyping, particularly for serum-contaminated samples.

  9. The Successful Diagnosis and Typing of Systemic Amyloidosis Using A Microwave-Assisted Filter-Aided Fast Sample Preparation Method and LC/MS/MS Analysis.

    Science.gov (United States)

    Sun, Weiyi; Sun, Jian; Zou, Lili; Shen, Kaini; Zhong, Dingrong; Zhou, Daobin; Sun, Wei; Li, Jian

    2015-01-01

    Laser microdissection followed by mass spectrometry has been successfully used for amyloid typing. However, sample contamination can interfere with proteomic analysis, and overnight digestion limits the analytical throughput. Moreover, current quantitative analysis methods are based on the spectrum count, which ignores differences in protein length and may lead to misdiagnoses. Here, we developed a microwave-assisted filter-aided sample preparation (maFASP) method that can efficiently remove contaminants with a 10-kDa cutoff ultrafiltration unit and can accelerate the digestion process with the assistance of a microwave. Additionally, two parameters (P- and D-scores) based on the exponentially modified protein abundance index were developed to define the existence of amyloid deposits and those causative proteins with the greatest abundance. Using our protocol, twenty cases of systemic amyloidosis that were well-typed according to clinical diagnostic standards (training group) and another twenty-four cases without subtype diagnoses (validation group) were analyzed. Using this approach, sample preparation could be completed within four hours. We successfully subtyped 100% of the cases in the training group, and the diagnostic success rate in the validation group was 91.7%. This maFASP-aided proteomic protocol represents an efficient approach for amyloid diagnosis and subtyping, particularly for serum-contaminated samples.

  10. A multistep approach to manage Fournier’s gangrene in a patient with unknown type II diabetes: surgery, hyperbaric oxygen, and vacuum-assisted closure therapy: a case report

    Directory of Open Access Journals (Sweden)

    Pastore Antonio Luigi

    2013-01-01

    Full Text Available Abstract Introduction Fournier’s gangrene is an infectious necrotizing fasciitis of the perineum and genital regions and has a high mortality rate. It is a synergistic infection caused by a mixture of aerobic and anaerobic organisms and predisposing factors, including diabetes mellitus, alcoholism, malnutrition, and low socioeconomic status. We report a case of Fournier’s gangrene in a patient with unknown type II diabetes submitted to 24-hour catheterization 15 days before gangrene onset. Case presentation The patient, a 60-year-old Caucasian man, presented with a swollen, edematous, emphysematous scrotum with a crepitant skin and a small circle of necrosis. A lack of resistance along the dartos fascia of the scrotum and Scarpa’s lower abdominal wall fascia combined with the presence of gas and pus during the first surgical debridement also supported the diagnosis of Fournier’s gangrene. On the basis of the microbiological culture, the patient was given multiple antibiotic therapy, combined hypoglycemic treatment, hyperbaric oxygen therapy, and several surgical debridements. After five days the infection was not completely controlled and a vacuum-assisted closure device therapy was started. Conclusions This report describes the successful multistep approach of an immediate surgical debridement combined with hyperbaric oxygen and negative pressure wound therapy. The vacuum-assisted closure is a well-known method used to treat complex wounds. In this case study, vacuum-assisted closure treatment was effective and the patient did not require reconstructive surgery. Our report shows that bladder catheterization, a minimally invasive maneuver, may also cause severe infective consequences in high-risk patients, such as patients with diabetes.

  11. [Nitrogen Losses Under the Action of Different Land Use Types of Small Catchment in Three Gorges Region].

    Science.gov (United States)

    Chen, Cheng-long; Gao, Ming; Ni, Jiu-pai; Xie, De-ti; Deng, Hua

    2016-05-15

    As an independent water-collecting area, small catchment is the source of non-point source pollution in Three Gorges Region. Choosing 3 kinds of the most representative land-use types and using them to lay monitoring points of overland runoff within the small catchment of Wangjiagou in Fuling of Three Gorges Region, the author used the samples of surface runoff collected through the twelve natural rainfalls from May to December to analyze the feature of spatial-temporal change of Nitrogen's losses concentrations under the influence of different land use types and the hillslopes and small catchments composed by those land use types, revealing the relation between different land-use types and Nitrogen's losses of small catchments in Three Gorges Region. The result showed: the average losses concentration of TN showed the biggest difference for different land use types during the period of spring crops, and the average value of dry land was 1. 61 times and 6.73 times of the values of interplanting field of mulberry and paddy field, respectively; the change of the losses concentration of TN was most conspicuous in the 3 periods of paddy field. The main element was NO₃⁻-N, and the relation between TN and NO₃⁻-N showed a significant linear correlation. TN's and NO₃⁻-N's losses concentrations were significantly and positively correlated with the area ratio of corn and mustard, but got a significant negative correlation with the area ratio of paddy and mulberry; NH₄⁺-N's losses concentrations got a significant positive correlation with the area ratio of mustard. Among all the hillslopes composed by different land use types, TN's average losses concentration of surface runoff of the hillslope composed by interplantating field of mulberry and paddy land during the three periods was the lowest, and the values were 2.55, 11.52, 8.58 mg · L⁻¹, respectively; the hillslope of rotation plough land of corn and mustard had the maximum value, and the values were

  12. The development of p-type silicon detectors for the high radiation regions of the LHC

    International Nuclear Information System (INIS)

    Hanlon, M.D.L.

    1998-04-01

    This thesis describes the production and characterisation of silicon microstrip detectors and test structures on p-type substrates. An account is given of the production and full parameterisation of a p-type microstrip detector, incorporating the ATLAS-A geometry in a beam test. This detector is an AC coupled device incorporating a continuous p-stop isolation frame and polysilicon biasing and is typical of n-strip devices proposed for operation at the LHC. It was successfully read out using the FELix-128 analogue pipeline chip and a signal to noise (s/n) of 17±1 is reported, along with a spatial resolution of 14.6±0.2 μm. Diode test structures were fabricated on both high resistivity float zone material and on epitaxial material and subsequently irradiated with 24 GeV protons at the CERN PS up to a dose of (8.22±0.23) x 10 14 per cm 2 . An account of the measurement program is presented along with results on the changes in the effective doping concentration (N eff ) with irradiation and the changes in bulk current. Changes in the effective doping concentration and leakage current for high resistivity p-type material under irradiation were found to be similar to to that of n-type material. Values of α=(3.30±0.08) x 10 -17 A cm -1 for the leakage current parameter and g c =(1.20±0.05)x10 -2 cm -1 for the effective dopant introduction rate were found for this material. The epitaxial material did not perform better than the float zone material for the range of doses studied. Surprising results were obtained for highly irradiated p-type diodes illuminated on the ohmic side with an α-source, in that signals were observed well below the full depletion voltage. The processing that had been used to fabricate the test structures and the initial prototype that was studied in the test beam was based on the process used to fabricate devices on n-type material. Presented in this thesis are the modifications that were made to the process, which centred on the oxidation

  13. Fat- and Fiber-Related Diet Behavior among Type 2 Diabetes Patients from Distinct Regions

    Czech Academy of Sciences Publication Activity Database

    Hendrychová, T.; Vytřísalová, M.; Alwarafi, A.; Duintjer Tebbens, Jurjen; Vaňkátová, H.; Leal, S.; Kuběna, A.A.; Šmahelová, A.; Vlček, J.

    2015-01-01

    Roč. 9, Article number A38 (2015), s. 319-325 ISSN 1177-889X R&D Projects: GA ČR GA13-06684S Grant - others:SVV UK(CZ) 260 066 Institutional support: RVO:67985807 Keywords : type 2 diabetes mellitus * fat-related behavior * fiber-related behavior * Fat- and Fiber-related Diet Behavior Questionnaire * geographical difference Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 1.718, year: 2015

  14. Ongoing outbreak of dengue type 1 in the Autonomous Region of Madeira, Portugal: preliminary report.

    Science.gov (United States)

    Sousa, C A; Clairouin, M; Seixas, G; Viveiros, B; Novo, M T; Silva, A C; Escoval, M T; Economopoulou, A

    2012-12-06

    Following the identification of two autochthonous cases of dengue type 1 on 3 October 2012, an outbreak of dengue fever has been reported in Madeira, Portugal. As of 25 November, 1,891 cases have been detected on the island where the vector Aedes aegypti had been established in some areas since 2005. This event represents the first epidemic of dengue fever in Europe since 1928 and concerted control measures have been initiated by local health authorities.

  15. Heavy metals in the small rivers of Ternopil region under different types of anthropogenic pressure

    Directory of Open Access Journals (Sweden)

    O. Prokopchuk

    2016-03-01

    Full Text Available The dynamic of content and peculiarities of migration of heavy metals in small rivers of Ternopil region were analyzed (Zn, Mn, Fe, Co, Ni, Pb. It was determined that cobalt does not exceed maximum permissible levels, whereas the content of other metals exceed these levels at rates from 2 to 42 times the emission limit set by the fishing industry. The waters of Ternopil region are the richest in the compounds of iron and manganese by virtue of the lithological content of the researched water basins. The excess in Mn and Fe concentration in river water is caused by occurrence of these elements in abiotic components of river valleys, particularly in areas with iron and manganese, alluvial deposits, clay soils with ferrous metal compounds and leaching of elements from rock, soil and forest litter. As our research showed, increased metal content in water basins is caused by natural factors (river running through areas with ore and where leaching of ore occurs it, reaction of interstitial water, metals appearing in ground water run-off, anthropogenic (waste waters of industrial plants, agricultural outwash, fuel combustion and hydrochemical factors of the hydroecosystem itself (consumption and releasing of metals by hydrobionts, aquatic habitat pH, metals coming in from ground sediments, metals released from complexes with organic compounds, methylation of non-organic metal compounds. A comparative analysis of the pollution levels of Ternopil region water basins by heavy metals was completed. It was determined that the river most heavily contaminated by the content of nutrients and non-biogenic HM is the Zolota Lypa and the cleanest is the River Strypa, which allows us to recommend the use of water composition as a reference indicator in assessing the ecological state of the region’s surface waters.

  16. SOURCE REGIONS OF THE TYPE II RADIO BURST OBSERVED DURING A CME–CME INTERACTION ON 2013 MAY 22

    International Nuclear Information System (INIS)

    Mäkelä, P.; Reiner, M. J.; Akiyama, S.; Gopalswamy, N.; Krupar, V.

    2016-01-01

    We report on our study of radio source regions during the type II radio burst on 2013 May 22 based on direction-finding analysis of the Wind /WAVES and STEREO /WAVES (SWAVES) radio observations at decameter–hectometric wavelengths. The type II emission showed an enhancement that coincided with the interaction of two coronal mass ejections (CMEs) launched in sequence along closely spaced trajectories. The triangulation of the SWAVES source directions posited the ecliptic projections of the radio sources near the line connecting the Sun and the STEREO-A spacecraft. The WAVES and SWAVES source directions revealed shifts in the latitude of the radio source, indicating that the spatial location of the dominant source of the type II emission varies during the CME–CME interaction. The WAVES source directions close to 1 MHz frequencies matched the location of the leading edge of the primary CME seen in the images of the LASCO/C3 coronagraph. This correspondence of spatial locations at both wavelengths confirms that the CME–CME interaction region is the source of the type II enhancement. Comparison of radio and white-light observations also showed that at lower frequencies scattering significantly affects radio wave propagation.

  17. Single nucleotide polymorphisms typing of Mycobacterium leprae reveals focal transmission of leprosy in high endemic regions of India.

    Science.gov (United States)

    Lavania, M; Jadhav, R S; Turankar, R P; Chaitanya, V S; Singh, M; Sengupta, U

    2013-11-01

    Earlier studies indicate that genotyping of Mycobaterium leprae based on single-nucleotide polymorphisms (SNPs) is useful for analysis of the global spread of leprosy. In the present study, we investigated the diversity of M. leprae at eight SNP loci using 180 clinical isolates obtained from patients with leprosy residing mainly in Delhi and Purulia (West Bengal) regions. It was observed that the frequency of SNP type 1 and subtype D was most predominant in the Indian population. Further, the SNP type 2 subtype E was noted only from East Delhi region and SNP type 2 subtype G was noted only from the nearby areas of Hoogly district of West Bengal. These results indicate the occurrence of focal transmission of M. leprae infection and demonstrate that analysis by SNP typing has great potential to help researchers in understanding the transmission of M. leprae infection in the community. © 2013 The Authors Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases.

  18. Constructing Regional Groundwater Models from Geophysical Data of Varying Type, Age, and Quality

    DEFF Research Database (Denmark)

    Vest Christiansen, Anders; Auken, Esben; Marker, Pernille Aabye

    for parameterization of a 3D model of the subsurface, integrating lithological information from boreholes with resistivity models. The objective is to create a direct input to regional groundwater models for sedimentary areas, where the sand/clay distribution governs the groundwater flow. The resistivity input is all......-inclusive in the sense that we include data from a variety of instruments (DC and EM, ground-based and airborne), with a varying spatial density and varying ages and quality. The coupling between hydrological and geophysical parameters is managed using a translator function with spatially variable parameters, which...

  19. Characterisation of botulinum toxins type A and B, by matrix-assisted laser desorption ionisation and electrospray mass spectrometry

    NARCIS (Netherlands)

    Baar, B.L.M. van; Hulst, A.G.; Jong, A.L. de; Wils, E.R.J.

    2002-01-01

    A method earlier developed for the mass spectrometric (MS) identification of tetanus toxin (TTx) was applied to botulinum toxins type A and B (BTxA and BTxB). Botulinum toxins are extremely neurotoxic bacterial toxins, likely to be used as biological warfare agent. Biologically active BTxA and BTxB

  20. The optimal on-source region size for detections with counting-type telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Klepser, Stefan

    2017-01-15

    The on-source region is typically a circular area with radius θ in which the signal is expected to appear with the shape of the instrument point spread function (PSF). This paper addresses the question of what is the θ that maximises the probability of detection for a given PSF width and background event density. In the high count number limit and assuming a Gaussian PSF profile, the optimum is found to be at ζ{sup 2}{sub ∞}∼2.51 times the squared PSF width σ{sup 2}{sub PSF39}. While this number is shown to be a good choice in many cases, a dynamic formula for cases of lower count numbers, which favour larger on-source regions, is given. The recipe to get to this parametrisation can also be applied to cases with a non-Gaussian PSF. This result can standardise and simplify analysis procedures, reduce trials and eliminate the need for experience-based ad hoc cut definitions or expensive case-by-case Monte Carlo simulations.

  1. The optimal on-source region size for detections with counting-type telescopes

    International Nuclear Information System (INIS)

    Klepser, Stefan

    2017-01-01

    The on-source region is typically a circular area with radius θ in which the signal is expected to appear with the shape of the instrument point spread function (PSF). This paper addresses the question of what is the θ that maximises the probability of detection for a given PSF width and background event density. In the high count number limit and assuming a Gaussian PSF profile, the optimum is found to be at ζ"2_∞∼2.51 times the squared PSF width σ"2_P_S_F_3_9. While this number is shown to be a good choice in many cases, a dynamic formula for cases of lower count numbers, which favour larger on-source regions, is given. The recipe to get to this parametrisation can also be applied to cases with a non-Gaussian PSF. This result can standardise and simplify analysis procedures, reduce trials and eliminate the need for experience-based ad hoc cut definitions or expensive case-by-case Monte Carlo simulations.

  2. Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial.

    Science.gov (United States)

    Nucci, Anita M; Virtanen, Suvi M; Sorkio, Susa; Bärlund, Sonja; Cuthbertson, David; Uusitalo, Ulla; Lawson, Margaret L; Salonen, Marja; Berseth, Carol L; Ormisson, Anne; Lehtonen, Eveliina; Savilahti, Erkki; Becker, Dorothy J; Dupré, John; Krischer, Jeffrey P; Knip, Mikael; Åkerblom, Hans K

    2017-07-01

    Differences in breastfeeding, other milk feeding and complementary feeding patterns were evaluated in infants at increased genetic risk with and without maternal type 1 diabetes (T1D). The Trial to Reduce IDDM in the Genetically at Risk is an international nutritional primary prevention double-blinded randomized trial to test whether weaning to extensively hydrolyzed vs. intact cow's milk protein formula will decrease the development of T1D-associated autoantibodies and T1D. Infant diet was prospectively assessed at two visits and seven telephone interviews between birth and 8 months. Countries were grouped into seven regions: Australia, Canada, Northern Europe, Southern Europe, Central Europe I, Central Europe II and the United States. Newborn infants with a first-degree relative with T1D and increased human leukocyte antigen-conferred susceptibility to T1D were recruited. A lower proportion of infants born to mothers with than without T1D were breastfed until 6 months of age in all regions (range, 51% to 60% vs. 70% to 80%). Complementary feeding patterns differed more by region than by maternal T1D. In Northern Europe, a higher proportion of infants consumed vegetables and fruits daily compared with other regions. Consumption of meat was more frequent in all European regions, whereas cereal consumption was most frequent in Southern Europe, Canada and the United States. Maternal T1D status was associated with breastfeeding and other milk feeding patterns similarly across regions but was unrelated to the introduction of complementary foods. Infant feeding patterns differed significantly among regions and were largely inconsistent with current recommended guidelines. © 2016 John Wiley & Sons Ltd.

  3. Career Trajectories of Municipal Servants: Two Types of Professional Mobility (Case Study in Novgorod Region

    Directory of Open Access Journals (Sweden)

    A A Kurakin

    2013-12-01

    Full Text Available The case study of a district in the Novgorod region shows some scenarios of recruiting new employees in the district and town municipalities, their work motivation and the most plausible career trajectories. The author argues that on the municipal level (district or its administrative center there are parallel career ladders for the top-ranked municipal clerks and for the rest of the municipal staff: the career trajectory of the high-ranked clerks can be described as a step-by-step trajectory, while the one of the lower-ranked employees — as a shuttle trajectory. There is an almost insurmountable border line between these two levels of municipal hierarchy, an obstacle for implementing the classical Weberian characteristics of “proper” bureaucracy: meritocratic recruitment and workers’ promotion and predictable long-term career ladders.

  4. The development of p-type silicon detectors for the high radiation regions of the LHC

    CERN Document Server

    Hanlon, M D L

    1998-01-01

    This thesis describes the production and characterisation of silicon microstrip detectors and test structures on p-type substrates. An account is given of the production and full parameterisation of a p-type microstrip detector, incorporating the ATLAS-A geometry in a beam test. This detector is an AC coupled device incorporating a continuous p-stop isolation frame and polysilicon biasing and is typical of n-strip devices proposed for operation at the LHC. It was successfully read out using the FELix-128 analogue pipeline chip and a signal to noise (s/n) of 17+-1 is reported, along with a spatial resolution of 14.6+-0.2 mu m. Diode test structures were fabricated on both high resistivity float zone material and on epitaxial material and subsequently irradiated with 24 GeV protons at the CERN PS up to a dose of (8.22+-0.23) x 10 sup 1 sup 4 per cm sup 2. An account of the measurement program is presented along with results on the changes in the effective doping concentration (N sub e sub f sub f) with irradiat...

  5. Postoperative B-Type Natriuretic Peptide as Predictor for Postoperative Outcomes in Patients Implanted With Left Ventricular Assist Devices.

    Science.gov (United States)

    Yost, Gardner; Bhat, Geetha; Pappas, Patroklos; Tatooles, Antone

    2018-04-18

    Brain natriuretic peptide (BNP) is a cardiac neurohormone known to correlate with left ventricular (LV) dilation, decreased contractility, and increased stiffness. Consequently, BNP has been used as a prognostic tool to assess the degree of LV unloading for patients supported by continuous-flow LV assist devices (LVADs). We assessed the prognostic value of changes in BNP in the 2 weeks after LVAD implantation. This retrospective study analyzed laboratory findings and outcomes of 189 LVAD patients. Patients were separated into two groups based on whether serum BNP levels had improved from preoperative levels by postoperative day 14. Group 1 had improvement in BNP levels, whereas group 2 had no improvement or worsening in BNP. There were no significant differences between the groups in age, gender, race, body mass index, or comorbidities. Group 1 had preoperative BNP 1,125 ± 1,078.3 pg/dl and postoperative BNP 440.2 ± 267.7 pg/dl (ΔBNP = -693.09 ± 942.4 pg/dl), whereas group 2 had preoperative BNP 346.0 ± 309.1 pg/dl and postoperative BNP 631.57 ± 483.4 pg/dl (ΔBNP = 289.32 ± 329.7 pg/dl). Postoperative survival in group 2 was significantly worse than in group 1. Rates of right ventricular failure (RVF) were significantly higher in group 2 (group 1: 39%, group 2: 52.7%; p = 0.01). In most patients implanted with a LVAD, BNP improves significantly in the postoperative period as the LV is unloaded. Our results indicate that lack of improvement in postoperative BNP is associated with longer length of stay, increased rates of RVF, and is an independent risk factor for reduced postoperative survival.

  6. Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines.

    Science.gov (United States)

    Boschiero, Clarissa; Moreira, Gabriel Costa Monteiro; Gheyas, Almas Ara; Godoy, Thaís Fernanda; Gasparin, Gustavo; Mariani, Pilar Drummond Sampaio Corrêa; Paduan, Marcela; Cesar, Aline Silva Mello; Ledur, Mônica Corrêa; Coutinho, Luiz Lehmann

    2018-01-25

    Meat and egg-type chickens have been selected for several generations for different traits. Artificial and natural selection for different phenotypes can change frequency of genetic variants, leaving particular genomic footprints throghtout the genome. Thus, the aims of this study were to sequence 28 chickens from two Brazilian lines (meat and white egg-type) and use this information to characterize genome-wide genetic variations, identify putative regions under selection using Fst method, and find putative pathways under selection. A total of 13.93 million SNPs and 1.36 million INDELs were identified, with more variants detected from the broiler (meat-type) line. Although most were located in non-coding regions, we identified 7255 intolerant non-synonymous SNPs, 512 stopgain/loss SNPs, 1381 frameshift and 1094 non-frameshift INDELs that may alter protein functions. Genes harboring intolerant non-synonymous SNPs affected metabolic pathways related mainly to reproduction and endocrine systems in the white-egg layer line, and lipid metabolism and metabolic diseases in the broiler line. Fst analysis in sliding windows, using SNPs and INDELs separately, identified over 300 putative regions of selection overlapping with more than 250 genes. For the first time in chicken, INDEL variants were considered for selection signature analysis, showing high level of correlation in results between SNP and INDEL data. The putative regions of selection signatures revealed interesting candidate genes and pathways related to important phenotypic traits in chicken, such as lipid metabolism, growth, reproduction, and cardiac development. In this study, Fst method was applied to identify high confidence putative regions under selection, providing novel insights into selection footprints that can help elucidate the functional mechanisms underlying different phenotypic traits relevant to meat and egg-type chicken lines. In addition, we generated a large catalog of line-specific and common

  7. Prioritizing stream types according to their potential risk to receive crop plant material--A GIS-based procedure to assist in the risk assessment of genetically modified crops and systemic insecticide residues.

    Science.gov (United States)

    Bundschuh, Rebecca; Kuhn, Ulrike; Bundschuh, Mirco; Naegele, Caroline; Elsaesser, David; Schlechtriemen, Ulrich; Oehen, Bernadette; Hilbeck, Angelika; Otto, Mathias; Schulz, Ralf; Hofmann, Frieder

    2016-03-15

    Crop plant residues may enter aquatic ecosystems via wind deposition or surface runoff. In the case of genetically modified crops or crops treated with systemic pesticides, these materials may contain insecticidal Bt toxins or pesticides that potentially affect aquatic life. However, the particular exposure pattern of aquatic ecosystems (i.e., via plant material) is not properly reflected in current risk assessment schemes, which primarily focus on waterborne toxicity and not on plant material as the route of uptake. To assist in risk assessment, the present study proposes a prioritization procedure of stream types based on the freshwater network and crop-specific cultivation data using maize in Germany as a model system. To identify stream types with a high probability of receiving crop materials, we developed a formalized, criteria-based and thus transparent procedure that considers the exposure-related parameters, ecological status--an estimate of the diversity and potential vulnerability of local communities towards anthropogenic stress--and availability of uncontaminated reference sections. By applying the procedure to maize, ten stream types out of 38 are expected to be the most relevant if the ecological effects from plant-incorporated pesticides need to be evaluated. This information is an important first step to identifying habitats within these stream types with a high probability of receiving crop plant material at a more local scale, including accumulation areas. Moreover, the prioritization procedure developed in the present study may support the selection of aquatic species for ecotoxicological testing based on their probability of occurrence in stream types having a higher chance of exposure. Finally, this procedure can be adapted to any geographical region or crop of interest and is, therefore, a valuable tool for a site-specific risk assessment of crop plants carrying systemic pesticides or novel proteins, such as insecticidal Bt toxins, expressed

  8. Types of traumatic brain injury and regional cerebral blood flow assessed by [sup 99m]Tc-HMPAO SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Yamakami, Iwao; Yamaura, Akira; Isobe, Katsumi [Chiba Univ. (Japan). School of Medicine

    1993-01-01

    To investigate the relationship between focal and diffuse traumatic brain injury (TBI) and regional cerebral blood flow (rCBF), rCBF changes in the first 24 hours post-trauma were studied in 12 severe head trauma patients using single photon emission computed tomography (SPECT) with [sup 99m]technetium-hexamethyl propyleneamine oxime (HMPAO). Patients were classified as focal or diffuse TBI based on x-ray computed tomographic (X-CT) findings and neurological signs. In six patients with focal damage, SPECT demonstrated: (1) perfusion defect (focal severe ischemia) in the brain region larger than the brain contusion by X-CT, (2) hypoperfusion (focal CBF reduction) in the brain region without abnormality by X-CT, and (3) localized hyperperfusion (focal CBF increase) in the surgically decompressed brain after decompressive craniectomy. Focal damage may be associated with a heterogeneous CBF change by causing various focal CBF derangements. In six patients with diffuse damage, SPECT revealed hypoperfusion in only one patient. Diffuse damage may be associated with a homogeneous CBF change by rarely causing focal CBF derangements. The type of TBI, focal or diffuse, determines the type of CBF change, heterogeneous or homogeneous, in the acute severe head trauma patient. (author).

  9. Types of traumatic brain injury and regional cerebral blood flow assessed by 99mTc-HMPAO SPECT.

    Science.gov (United States)

    Yamakami, I; Yamaura, A; Isobe, K

    1993-01-01

    To investigate the relationship between focal and diffuse traumatic brain injury (TBI) and regional cerebral blood flow (rCBF), rCBF changes in the first 24 hours post-trauma were studied in 12 severe head trauma patients using single photon emission computed tomography (SPECT) with 99mtechnetium-hexamethyl propyleneamine oxime. Patients were classified as focal or diffuse TBI based on x-ray computed tomographic (X-CT) findings and neurological signs. In six patients with focal damage, SPECT demonstrated 1) perfusion defect (focal severe ischemia) in the brain region larger than the brain contusion by X-CT, 2) hypoperfusion (focal CBF reduction) in the brain region without abnormality by X-CT, and 3) localized hyperperfusion (focal CBF increase) in the surgically decompressed brain after decompressive craniectomy. Focal damage may be associated with a heterogeneous CBF change by causing various focal CBF derangements. In six patients with diffuse damage, SPECT revealed hypoperfusion in only one patient. Diffuse damage may be associated with a homogeneous CBF change by rarely causing focal CBF derangements. The type of TBI, focal or diffuse, determines the type of CBF change, heterogeneous or homogeneous, in the acute severe head trauma patient.

  10. Types of traumatic brain injury and regional cerebral blood flow assessed by 99mTc-HMPAO SPECT

    International Nuclear Information System (INIS)

    Yamakami, Iwao; Yamaura, Akira; Isobe, Katsumi

    1993-01-01

    To investigate the relationship between focal and diffuse traumatic brain injury (TBI) and regional cerebral blood flow (rCBF), rCBF changes in the first 24 hours post-trauma were studied in 12 severe head trauma patients using single photon emission computed tomography (SPECT) with 99m technetium-hexamethyl propyleneamine oxime (HMPAO). Patients were classified as focal or diffuse TBI based on x-ray computed tomographic (X-CT) findings and neurological signs. In six patients with focal damage, SPECT demonstrated: 1) perfusion defect (focal severe ischemia) in the brain region larger than the brain contusion by X-CT, 2) hypoperfusion (focal CBF reduction) in the brain region without abnormality by X-CT, and 3) localized hyperperfusion (focal CBF increase) in the surgically decompressed brain after decompressive craniectomy. Focal damage may be associated with a heterogeneous CBF change by causing various focal CBF derangements. In six patients with diffuse damage, SPECT revealed hypoperfusion in only one patient. Diffuse damage may be associated with a homogeneous CBF change by rarely causing focal CBF derangements. The type of TBI, focal or diffuse, determines the type of CBF change, heterogeneous or homogeneous, in the acute severe head trauma patient. (author)

  11. Intravenous regional block is similar to sympathetic ganglion block for pain management in patients with complex regional pain syndrome type I

    Directory of Open Access Journals (Sweden)

    M.S.A. Nascimento

    2010-12-01

    Full Text Available Sympathetic ganglion block (SGB or intravenous regional block (IVRB has been recommended for pain management in patients with complex regional pain syndrome type I (CRPS-I. Forty-five patients were initially selected but only 43 were accepted for the study. The present study evaluated the efficacy of IVRB produced by combining 70 mg lidocaine with 30 µg clonidine (14 patients, 1 male/13 females, age range: 27-50 years versus SGB produced by the injection of 70 mg lidocaine alone (14 patients, 1 male/13 females, age range: 27-54 years or combined with 30 µg clonidine (15 patients, 1 male/14 females, age range: 25-50 years into the stellate ganglion for pain management in patients with upper extremity CRPS-I. Each procedure was repeated five times at 7-day intervals, and pain intensity and duration were measured using a visual analog scale immediately before each procedure. A progressive and significant reduction in pain scores and a significant increase in the duration of analgesia were observed in all groups following the first three blocks, but no further improvement was obtained following the last two blocks. Drowsiness, the most frequent side effect, and dry mouth occurred only in patients submitted to SGB with lidocaine combined with clonidine. The three methods were similar regarding changes in pain intensity and duration of analgesia. However, IVRB seems to be preferable to SGB due to its easier execution and lower risk of undesirable effects.

  12. Frequency of twelve carcinogenic human papilloma virus types among women from the South Backa region, Vojvodina, Serbia.

    Science.gov (United States)

    Kovacevic, Gordana; Nikolic, Natasa; Jovanovic-Galovic, Aleksandra; Hrnjakovic-Cvjetkovic, Iv; Vuleta, Dusan; Patic, Aleksandra; Radovanov, Jelena; Milosevic, Vesna

    2016-01-05

    The aim of this study was to determine the presence and age distribution of different oncogenic human papilloma virus (HPV) types in women in the South Backa region and its relationship to Pap results. In a group of 1087 women with normal and abnormal cytology, the commercial HR HPV Real-TM kit (Sacace Biotechnologies, Italy) was used. Overall, 50.5% of the women were HPV positive. The presence of HPV types 18, 31, 51, and 58 was significantly influenced by age, while the presence of HPV types 16 and 45 was significantly influenced by cervical cytology. Results of the LSD test show a wide spectrum of high risk HPV among women with normal cytology and women with a low grade cervical lesion rate (atypical squamous cell of undetermined significance (ASCUS) and low grade squamous intraepithelial lesions (LSIL). The most prevalent HPV types found were 16, 31, 51, 18, and 52. In the HSIL group the most prevalent HPV types were 16 and 45. The reported results provide new data on the circulation of oncogenic HPV genotypes and frequency of multiple infections among women in Vojvodina and suggest that a prophylactic vaccine against HPV 16 and 18 has the potential to prevent approximately half of the high-grade lesions.

  13. Assembly mechanism of FCT region type 1 pili in serotype M6 Streptococcus pyogenes.

    Science.gov (United States)

    Nakata, Masanobu; Kimura, Keiji Richard; Sumitomo, Tomoko; Wada, Satoshi; Sugauchi, Akinari; Oiki, Eiji; Higashino, Miharu; Kreikemeyer, Bernd; Podbielski, Andreas; Okahashi, Nobuo; Hamada, Shigeyuki; Isoda, Ryutaro; Terao, Yutaka; Kawabata, Shigetada

    2011-10-28

    The human pathogen Streptococcus pyogenes produces diverse pili depending on the serotype. We investigated the assembly mechanism of FCT type 1 pili in a serotype M6 strain. The pili were found to be assembled from two precursor proteins, the backbone protein T6 and ancillary protein FctX, and anchored to the cell wall in a manner that requires both a housekeeping sortase enzyme (SrtA) and pilus-associated sortase enzyme (SrtB). SrtB is primarily required for efficient formation of the T6 and FctX complex and subsequent polymerization of T6, whereas proper anchoring of the pili to the cell wall is mainly mediated by SrtA. Because motifs essential for polymerization of pilus backbone proteins in other Gram-positive bacteria are not present in T6, we sought to identify the functional residues involved in this process. Our results showed that T6 encompasses the novel VAKS pilin motif conserved in streptococcal T6 homologues and that the lysine residue (Lys-175) within the motif and cell wall sorting signal of T6 are prerequisites for isopeptide linkage of T6 molecules. Because Lys-175 and the cell wall sorting signal of FctX are indispensable for substantial incorporation of FctX into the T6 pilus shaft, FctX is suggested to be located at the pilus tip, which was also implied by immunogold electron microscopy findings. Thus, the elaborate assembly of FCT type 1 pili is potentially organized by sortase-mediated cross-linking between sorting signals and the amino group of Lys-175 positioned in the VAKS motif of T6, thereby displaying T6 and FctX in a temporospatial manner.

  14. Effectiveness of technology-assisted case management in low income adults with type 2 diabetes (TACM-DM: study protocol for a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Strom Joni L

    2011-10-01

    Full Text Available Abstract Background An estimated 1 in 3 American adults will have diabetes by the year 2050. Nationally, South Carolina ranks 10th in cases of diagnosed diabetes compared to other states. In adults, type 2 diabetes (T2DM accounts for approximately 90-95% of all diagnosed cases of diabetes. Clinically, provider and health system factors account for Methods We describe a four-year prospective, randomized clinical trial, which will test the effectiveness of technology-assisted case management in low income rural adults with T2DM. Two-hundred (200 male and female participants, 18 years of age or older and with an HbA1c ≥ 8%, will be randomized into one of two groups: (1 an intervention arm employing the innovative FORA system coupled with nurse case management or (2 a usual care group. Participants will be followed for 6-months to ascertain the effect of the interventions on glycemic control. Our primary hypothesis is that among indigent, rural adult patients with T2DM treated in FQHC's, participants randomized to the technology-assisted case management intervention will have significantly greater reduction in HbA1c at 6 months of follow-up compared to usual care. Discussion Results from this study will provide important insight into the effectiveness of technology-assisted case management intervention (TACM for optimizing diabetes care in indigent, rural adult patients with T2DM treated in FQHC's. Trial Registration National Institutes of Health Clinical Trials Registry (http://ClinicalTrials.gov identifier# NCT01373489

  15. Daily Public Assistance Grants Award Activity

    Data.gov (United States)

    Department of Homeland Security — Daily activity of Public Assistance Grant Awards, including FEMA Region, State, Disaster Declaration Number, Event description, Mission Assigned agency, Assistance...

  16. Sequence analysis and typing of Saprolegnia strains isolated from freshwater fish from Southern Chinese regions

    Directory of Open Access Journals (Sweden)

    Siya Liu

    2017-09-01

    Full Text Available Saprolegniasis, caused by Saprolegnia infection, is one of the most common diseases in freshwater fish. Our study aimed to determine the epidemiological characteristics of saprolegniasis in Chinese regions of high incidence. Saprolegnia were isolated and identified by morphological and molecular methods targeting the internal transcribed spacer (ITS ribosomal DNA (rDNA and building neighbor-joining (NJ and maximum parsimony (MP phylogenetic trees. The ITS sequences of eight isolated strains were compared with GenBank sequences and all strains fell into three clades: CLADE1 (02, LP, 04 and 14, CLADE2 (S1, and CLADE3 (CP, S2, L5 and the reference ATCC200013. Isolates 02 and LP shared 80% sequence similarity with S. diclina, S. longicaulis, S. ferax, S. mixta, and S. anomalies. Further, isolates 04 and 14 shared 80% similarity with S. bulbosa and S. oliviae. Finally, extremely high ITS sequence similarities were identified between isolates S1 and S. australis (100%; CP and S. hypogyna (96%; and S2, L5, ATCC200013 and S. salmonis (98%. This research provides insights into the identification, prevention and control of saprolegniasis pathogens and the potential development of effective drugs.

  17. Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I.

    Directory of Open Access Journals (Sweden)

    Volker Huge

    Full Text Available BACKGROUND: Sensory abnormalities are a key feature of Complex Regional Pain Syndrome (CRPS. In order to characterise these changes in patients suffering from acute or chronic CRPS I, we used Quantitative Sensory Testing (QST in comparison to an age and gender matched control group. METHODS: 61 patients presenting with CRPS I of the upper extremity and 56 healthy subjects were prospectively assessed using QST. The patients' warm and cold detection thresholds (WDT; CDT, the heat and cold pain thresholds (HPT; CPT and the occurrence of paradoxical heat sensation (PHS were observed. RESULTS: In acute CRPS I, patients showed warm and cold hyperalgesia, indicated by significant changes in HPT and CPT. WDT and CDT were significantly increased as well, indicating warm and cold hypoaesthesia. In chronic CRPS, thermal hyperalgesia declined, but CDT as well as WDT further deteriorated. Solely patients with acute CRPS displayed PHS. To a minor degree, all QST changes were also present on the contralateral limb. CONCLUSIONS: We propose three pathomechanisms of CRPS I, which follow a distinct time course: Thermal hyperalgesia, observed in acute CRPS, indicates an ongoing aseptic peripheral inflammation. Thermal hypoaesthesia, as detected in acute and chronic CRPS, signals a degeneration of A-delta and C-fibres, which further deteriorates in chronic CRPS. PHS in acute CRPS I indicates that both inflammation and degeneration are present, whilst in chronic CRPS I, the pathomechanism of degeneration dominates, signalled by the absence of PHS. The contralateral changes observed strongly suggest the involvement of the central nervous system.

  18. Local cytokine changes in complex regional pain syndrome type I (CRPS I) resolve after 6 months.

    Science.gov (United States)

    Lenz, Melanie; Uçeyler, Nurcan; Frettlöh, Jule; Höffken, Oliver; Krumova, Elena K; Lissek, Silke; Reinersmann, Annika; Sommer, Claudia; Stude, Philipp; Waaga-Gasser, Ana M; Tegenthoff, Martin; Maier, Christoph

    2013-10-01

    There is evidence that inflammatory processes are involved in at least the early phase of complex regional pain syndrome (CRPS). We compared a panel of pro- and antiinflammatory cytokines in skin blister fluids and serum from patients with CRPS and patients with upper-limb pain of other origin (non-CRPS) in the early stage (CRPS patients compared to non-CRPS patients. Neither group showed side differences. After 6 months under analgesic treatment, protein levels of all measured cytokines in CRPS patients, except for IL-6, significantly changed bilaterally to the level of non-CRPS patients. These changes were not related to treatment outcome. In serum, only IL-8, TNF-α, eotaxin, MCP-1, and MIP-1β were detectable without intergroup differences. Blister fluid of CRPS patients showed a bilateral proinflammatory cytokine profile. This profile seems to be relevant only at the early stage of CRPS. Almost all measured cytokine levels were comparable to those of non-CRPS patients after 6 months of analgesic treatment and were not related to treatment outcome. Copyright © 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  19. Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I).

    Science.gov (United States)

    Huge, Volker; Lauchart, Meike; Förderreuther, Stefanie; Kaufhold, Wibke; Valet, Michael; Azad, Shahnaz Christina; Beyer, Antje; Magerl, Walter

    2008-07-23

    Sensory abnormalities are a key feature of Complex Regional Pain Syndrome (CRPS). In order to characterise these changes in patients suffering from acute or chronic CRPS I, we used Quantitative Sensory Testing (QST) in comparison to an age and gender matched control group. 61 patients presenting with CRPS I of the upper extremity and 56 healthy subjects were prospectively assessed using QST. The patients' warm and cold detection thresholds (WDT; CDT), the heat and cold pain thresholds (HPT; CPT) and the occurrence of paradoxical heat sensation (PHS) were observed. In acute CRPS I, patients showed warm and cold hyperalgesia, indicated by significant changes in HPT and CPT. WDT and CDT were significantly increased as well, indicating warm and cold hypoaesthesia. In chronic CRPS, thermal hyperalgesia declined, but CDT as well as WDT further deteriorated. Solely patients with acute CRPS displayed PHS. To a minor degree, all QST changes were also present on the contralateral limb. We propose three pathomechanisms of CRPS I, which follow a distinct time course: Thermal hyperalgesia, observed in acute CRPS, indicates an ongoing aseptic peripheral inflammation. Thermal hypoaesthesia, as detected in acute and chronic CRPS, signals a degeneration of A-delta and C-fibres, which further deteriorates in chronic CRPS. PHS in acute CRPS I indicates that both inflammation and degeneration are present, whilst in chronic CRPS I, the pathomechanism of degeneration dominates, signalled by the absence of PHS. The contralateral changes observed strongly suggest the involvement of the central nervous system.

  20. Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity.

    Science.gov (United States)

    Wang, Liwei; Wagner, Larry E; Alzayady, Kamil J; Yule, David I

    2017-07-14

    The inositol 1,4,5 trisphosphate receptor (IP 3 R) is an intracellular Ca 2+ release channel expressed predominately on the membranes of the endoplasmic reticulum. IP 3 R1 can be cleaved by caspase or calpain into at least two receptor fragments. However, the functional consequences of receptor fragmentation are poorly understood. Our previous work has demonstrated that IP 3 R1 channels, formed following either enzymatic fragmentation or expression of the corresponding complementary polypeptide chains, retain tetrameric architecture and are still activated by IP 3 binding despite the loss of peptide continuity. In this study, we demonstrate that region-specific receptor fragmentation modifies channel regulation. Specifically, the agonist-evoked temporal Ca 2+ release profile and protein kinase A modulation of Ca 2+ release are markedly altered. Moreover, we also demonstrate that activation of fragmented IP 3 R1 can result in a distinct functional outcome. Our work suggests that proteolysis of IP 3 R1 may represent a novel form of modulation of IP 3 R1 channel function and increases the repertoire of Ca 2+ signals achievable through this channel. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  1. Surface albedo in different land-use and cover types in Amazon forest region

    Directory of Open Access Journals (Sweden)

    Thiago de Oliveira Faria

    2018-05-01

    Full Text Available Albedo is the portion of energy from the Sun that is reflected by the earth's surface, thus being an important variable that controls climate and energy processes on Earth. Surface albedo is directly related to the characteristics of the Earth’s surface materials, making it a useful parameter to evaluate the effects of original soil cover replacement due to human occupation. This study evaluated the changes in the surface albedo values due to the conversion of vegetation to other land uses and to analyze the applicability of the use of albedo in the spatial delimitation of land-use classes in the transitional region between the Cerrado and Amazon biomes. Surface albedo measurements were obtained from processing of Landsat Thematic Mapper data in the Geographic Information System (GIS, and land-use information were collected using Google Earth high-resolution images. The results show that human activities such as the cultivation of crops and burning have contributed substantially to variations in the surface albedo, and that albedo estimates from Landsat imagery have the potential to help in the recognition and delimitation of features of land use and cover.

  2. Biological characterization of HIV type 1 envelope V3 regions from mothers and infants associated with perinatal transmission.

    Science.gov (United States)

    Matala, E; Hahn, T; Yedavalli, V R; Ahmad, N

    2001-12-10

    Our previous study has shown that the human immunodeficiency virus type 1 (HIV-1) envelope V3 region minor genotypes of infected mothers were transmitted to their infants and predominated initially as a homogeneous virus population in the infants (Ahmad N, Baroudy BM, Baker RC, et al.: J Virol 1995;69:1001-1012). Here we have characterized the biological properties, including cellular tropism, replication efficiency, cytopathic effects, and coreceptor utilization, of these V3 region isolates from mothers and infants. Nineteen V3 region sequences from three mother-infant pairs, including the minor variants of mothers and the major variants of infants as characterized in our previous study, were reciprocally inserted into an HIV-1 infectious molecular clone, pNL4-3, and chimeric viruses were generated by DNA transfections into HeLa cells. Equal amounts of chimeric viruses were then used to infect T lymphocyte cell lines (A3.01 and MT-2), primary blood lymphocytes (PBLs), primary monocyte-derived macrophages (MDMs), and coreceptor cell lines. We found that the V3 region chimeras failed to replicate in T lymphocyte cell lines but replicated in MDMs and PBLs, albeit at reduced levels compared with R5 laboratory HIV-1 strains. In addition, the V3 region chimeras were able to infect the HOS-CD4(+)CCR5(+) cell line, suggesting CCR5 coreceptor utilization. Moreover, the V3 region chimeras were unable to induce syncytia in MT-2 cells, indicative of non-syncytium-inducing (NSI) phenotypes. In conclusion, the HIV-1 minor genotypes of infected mothers with macrophage-tropic and NSI or R5 phenotypes are transmitted to their infants and are initially maintained with the same properties.

  3. Mirror box therapy added to cognitive behavioural therapy in three chronic complex regional pain syndrome type I patients : a pilot study

    NARCIS (Netherlands)

    Tichelaar, Y. I. G. Vladimir; Geertzen, Jan H. B.; Keizer, Doeke; van Wilgen, C. Paul

    Complex regional pain syndrome type I is a disorder of the extremities with disability and pain as the most prominent features. This paper describes the results of cognitive behavioural therapy combined with mirror box therapy in three patients with chronic complex regional pain syndrome type I.

  4. Fat- and fiber-related diet behavior among type 2 diabetes patients from distinct regions

    Directory of Open Access Journals (Sweden)

    Hendrychova T

    2015-02-01

    Full Text Available Tereza Hendrychova,1 Magda Vytrisalova,1 Abdullah Alwarafi,2 Jurjen Duintjer Tebbens,3,4 Helena Vankatova,1 Sandra Leal,5 Ales Antonin Kubena,1 Alena Smahelova,6 Jiri Vlcek1 1Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic; 2Faculty of Dentistry, Ibb University, Ibb, Yemen; 3Department of Biophysics and Physical Chemics, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic; 4Institute of Computer Science, Academy of Sciences of the Czech Republic, Prague, Czech Republic; 5Department of Clinical Pharmacy, El Rio Community Health Center, Tucson, AZ, USA; 6Diabetes Center, Department of Gerontology and Metabolism, University Hospital and Faculty of Medicine in Hradec Králové, Charles University in Prague, Hradec Králové, Czech Republic Purpose: Diet and eating habits are of key importance in patients with type 2 diabetes mellitus (T2DM. The purpose of this comparative study was to analyze fat- and fiber-related behavior (FFB in patients with T2DM from distinct cultural areas. Patients and methods: Observational study was carried out in the Czech Republic (CR (n=200, the US (n=207, and Yemen (n=200. Patients completed the Fat- and Fiber-related Diet Behavior Questionnaire (FFBQ. Results: Differences in all aspects of FFB among countries were found (P<0.05. The best fat-related behavior reported was from patients from the CR. Patients from the US showed the worst fat-related behavior in total. On the other hand, patients from the US reported the best fiber-related behavior. Patients from Yemen reached the worst scores in all fat-related domains. Patients from all studied countries reported the best results in the “modify meat” and “avoid fat as flavoring” and the worst in the “substitute high fiber” subscales. Conclusion: Professionals involved in the diet education of T2DM patients

  5. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry: a new possibility for the identification and typing of anaerobic bacteria.

    Science.gov (United States)

    Nagy, Elizabeth

    2014-01-01

    Anaerobic bacteria predominate in the normal flora of humans and are important, often life-threatening pathogens in mixed infections originating from the indigenous microbiota. The isolation and identification of anaerobes by phenotypic and DNA-based molecular methods at a species level is time-consuming and laborious. Following the successful adaptation of the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for the routine laboratory identification of bacteria, the extensive development of a database has been initiated to use this method for the identification of anaerobic bacteria. Not only frequently isolated anaerobic species, but also newly recognized and taxonomically rearranged genera and species can be identified using direct smear samples or whole-cell protein extraction, and even phylogenetically closely related species can be identified correctly by means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Typing of anaerobic bacteria on a subspecies level, determination of antibiotic resistance and direct identification of blood culture isolates will revolutionize anaerobe bacteriology in the near future.

  6. Effect of vegetation types on soil arbuscular mycorrhizal fungi and nitrogen-fixing bacterial communities in a karst region.

    Science.gov (United States)

    Liang, Yueming; Pan, Fujing; He, Xunyang; Chen, Xiangbi; Su, Yirong

    2016-09-01

    Arbuscular mycorrhizal (AM) fungi and nitrogen-fixing bacteria play important roles in plant growth and recovery in degraded ecosystems. The desertification in karst regions has become more severe in recent decades. Evaluation of the fungal and bacterial diversity of such regions during vegetation restoration is required for effective protection and restoration in these regions. Therefore, we analyzed relationships among AM fungi and nitrogen-fixing bacteria abundances, plant species diversity, and soil properties in four typical ecosystems of vegetation restoration (tussock (TK), shrub (SB), secondary forest (SF), and primary forest (PF)) in a karst region of southwest China. Abundance of AM fungi and nitrogen-fixing bacteria, plant species diversity, and soil nutrient levels increased from the tussock to the primary forest. The AM fungus, nitrogen-fixing bacterium, and plant community composition differed significantly between vegetation types (p fungi and nitrogen-fixing bacteria, respectively. Available phosphorus, total nitrogen, and soil organic carbon levels and plant richness were positively correlated with the abundance of AM fungi and nitrogen-fixing bacteria (p fungi and nitrogen-fixing bacteria increased from the tussock to the primary forest and highlight the essentiality of these communities for vegetation restoration.

  7. PHARMACOEPIDEMIOLOGIC ANALYSIS OF ST-ELEVATION MYOCARDIAL INFARCTION REPERFUSION THERAPY AT SARATOV REGION HOSPITALS OF DIFFERENT TYPES

    Directory of Open Access Journals (Sweden)

    O. V. Reshetko

    2016-01-01

    Full Text Available Aim. To evaluate the real practice of thrombolytic therapy of patients with ST-elevation myocardial infarction (STEMI at cardiological departments of Saratov and Saratov region hospitals.Material and methods. Retrospective pharmacoepidemiologic study was carried out. Case histories of STEMI patients discharged from cardiologic departments of several central district hospitals (CDH of Saratov region, cardiologic department of one of Saratov general municipal hospitals (MH and urgent cardiology department of Saratov clinical hospital (CH in 2006 were analyzed.Results. In CH all patients received thrombolytic therapy given they did not have contraindications and were admitted to the hospital timely. Few patients received thrombolytic therapy in MH and CDH in 2006.Conclusion. Correlation between hospital type and quality of STEMI management has been revealed.

  8. Glycoprotein I of herpes simplex virus type 1 contains a unique polymorphic tandem-repeated mucin region

    DEFF Research Database (Denmark)

    Norberg, Peter; Olofsson, Sigvard; Tarp, Mads Agervig

    2007-01-01

    Glycoprotein I (gI) of herpes simplex virus type 1 (HSV-1) contains a tandem repeat (TR) region including the amino acids serine and threonine, residues that can be utilized for O-glycosylation. The length of this TR region was determined for 82 clinical HSV-1 isolates and the results revealed......-glycosylation not only for the two most commonly expressed N-acetyl-d-galactosamine (GalNAc)-T1 and -T2 transferases, but also for the GalNAc-T3, -T4 and -T11 transferases. Immunoblotting of virus-infected cells showed that gI was exclusively O-glycosylated with GalNAc monosaccharides (Tn antigen). A polymorphic mucin...

  9. Synapsin I (Protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia. [Radioimmunoassay

    Energy Technology Data Exchange (ETDEWEB)

    Adolfsson, R; Alafuzoff, I; Winblad, B [Umeaa Univ. (Sweden); Perdahl, E; Albert, K A; Nestler, E J; Greengard, P [Rockefeller Univ., New York (USA)

    1984-01-01

    Synapsin I (Protein I), a neuron-specfic phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), from patients with multi-infarct dementia (MID), and from agematched controls. Samples were obtained at autopsy. Lower levels of Synapsin I were observed in the hippocampus of patients with AD/SDAT but not with MID. There were no significant differences in Synapsin I levels between patients and controls in any of the other four brain regions examined.

  10. Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia

    International Nuclear Information System (INIS)

    Adolfsson, R.; Alafuzoff, I.; Winblad, B.; Perdahl, E.; Albert, K.A.; Nestler, E.J.; Greengard, P.

    1984-01-01

    Synapsin I (Protein I), a neuron-specfic phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), from patients with multi-infarct dementia (MID), and from agematched controls. Samples were obtained at autopsy. Lower levels of Synapsin I were observed in the hippocampus of patients with AD/SDAT but not with MID. There were no significant differences in Synapsin I levels between patients and controls in any of the other four brain regions examined. (Author)

  11. Hair cycle in dogs with different hair types in a tropical region of Brazil.

    Science.gov (United States)

    Favarato, Evandro S; Conceição, Lissandro Gonçalves

    2008-02-01

    Hair cycle activity has been extensively studied in humans, sheep and laboratory animals, but there is a lack of information in dogs. Besides varying according to species, breed, sex and general health, hair growth is mainly affected by climatic variations. The aim of the study was to evaluate the follicle activity in three breeds of dogs with different hair types, in the city of Viçosa, Minas Gerais (latitude 20 degrees 45'S), Brazil. Twenty-one male dogs of boxer, labrador and schnauzer breeds were trichographically analysed monthly over 12 consecutive months. Hair percentage of telogen and anagen hairs at the different stages of the hair cycle in boxers and labradors was not significantly different, but both differed from the schnauzers. A significant correlation between hair follicle cycle and environmental temperature and photoperiod was noted in the boxers and labradors. In these breeds, a larger number of telogen hairs were observed during the hottest months of the year, and an increase in anagen hairs during the coldest months. The mean percentage of telogen hairs was 93, 90 and 55.3% for boxer, labrador and schnauzer, respectively.

  12. Screening of MITF and SOX10 regulatory regions in Waardenburg syndrome type 2.

    Directory of Open Access Journals (Sweden)

    Viviane Baral

    Full Text Available Waardenburg syndrome (WS is a rare auditory-pigmentary disorder that exhibits varying combinations of sensorineural hearing loss and pigmentation defects. Four subtypes are clinically defined based on the presence or absence of additional symptoms. WS type 2 (WS2 can result from mutations within the MITF or SOX10 genes; however, 70% of WS2 cases remain unexplained at the molecular level, suggesting that other genes might be involved and/or that mutations within the known genes escaped previous screenings. The recent identification of a deletion encompassing three of the SOX10 regulatory elements in a patient presenting with another WS subtype, WS4, defined by its association with Hirschsprung disease, led us to search for deletions and point mutations within the MITF and SOX10 regulatory elements in 28 yet unexplained WS2 cases. Two nucleotide variations were identified: one in close proximity to the MITF distal enhancer (MDE and one within the U1 SOX10 enhancer. Functional analyses argued against a pathogenic effect of these variations, suggesting that mutations within regulatory elements of WS genes are not a major cause of this neurocristopathy.

  13. Screening of MITF and SOX10 Regulatory Regions in Waardenburg Syndrome Type 2

    Science.gov (United States)

    Baral, Viviane; Chaoui, Asma; Watanabe, Yuli; Goossens, Michel; Attie-Bitach, Tania; Marlin, Sandrine; Pingault, Veronique; Bondurand, Nadege

    2012-01-01

    Waardenburg syndrome (WS) is a rare auditory-pigmentary disorder that exhibits varying combinations of sensorineural hearing loss and pigmentation defects. Four subtypes are clinically defined based on the presence or absence of additional symptoms. WS type 2 (WS2) can result from mutations within the MITF or SOX10 genes; however, 70% of WS2 cases remain unexplained at the molecular level, suggesting that other genes might be involved and/or that mutations within the known genes escaped previous screenings. The recent identification of a deletion encompassing three of the SOX10 regulatory elements in a patient presenting with another WS subtype, WS4, defined by its association with Hirschsprung disease, led us to search for deletions and point mutations within the MITF and SOX10 regulatory elements in 28 yet unexplained WS2 cases. Two nucleotide variations were identified: one in close proximity to the MITF distal enhancer (MDE) and one within the U1 SOX10 enhancer. Functional analyses argued against a pathogenic effect of these variations, suggesting that mutations within regulatory elements of WS genes are not a major cause of this neurocristopathy. PMID:22848661

  14. A novel polymorphism in the coding region of the vasopressin type 2 receptor gene

    Directory of Open Access Journals (Sweden)

    J.L. Rocha

    1997-04-01

    Full Text Available Nephrogenic diabetes insipidus (NDI is a rare disease characterized by renal inability to respond properly to arginine vasopressin due to mutations in the vasopressin type 2 receptor (V2(R gene in affected kindreds. In most kindreds thus far reported, the mode of inheritance follows an X chromosome-linked recessive pattern although autosomal-dominant and autosomal-recessive modes of inheritance have also been described. Studies demonstrating mutations in the V2(R gene in affected kindreds that modify the receptor structure, resulting in a dys- or nonfunctional receptor have been described, but phenotypically indistinguishable NDI patients with a structurally normal V2(R gene have also been reported. In the present study, we analyzed exon 3 of the V2(R gene in 20 unrelated individuals by direct sequencing. A C®T alteration in the third position of codon 331 (AGC®AGT, which did not alter the encoded amino acid, was found in nine individuals, including two unrelated patients with NDI. Taken together, these observations emphasize the molecular heterogeneity of a phenotypically homogeneous syndrome

  15. Screening of MITF and SOX10 regulatory regions in Waardenburg syndrome type 2.

    Science.gov (United States)

    Baral, Viviane; Chaoui, Asma; Watanabe, Yuli; Goossens, Michel; Attie-Bitach, Tania; Marlin, Sandrine; Pingault, Veronique; Bondurand, Nadege

    2012-01-01

    Waardenburg syndrome (WS) is a rare auditory-pigmentary disorder that exhibits varying combinations of sensorineural hearing loss and pigmentation defects. Four subtypes are clinically defined based on the presence or absence of additional symptoms. WS type 2 (WS2) can result from mutations within the MITF or SOX10 genes; however, 70% of WS2 cases remain unexplained at the molecular level, suggesting that other genes might be involved and/or that mutations within the known genes escaped previous screenings. The recent identification of a deletion encompassing three of the SOX10 regulatory elements in a patient presenting with another WS subtype, WS4, defined by its association with Hirschsprung disease, led us to search for deletions and point mutations within the MITF and SOX10 regulatory elements in 28 yet unexplained WS2 cases. Two nucleotide variations were identified: one in close proximity to the MITF distal enhancer (MDE) and one within the U1 SOX10 enhancer. Functional analyses argued against a pathogenic effect of these variations, suggesting that mutations within regulatory elements of WS genes are not a major cause of this neurocristopathy.

  16. Impaired spatial body representation in complex regional pain syndrome type 1 (CRPS I).

    Science.gov (United States)

    Reinersmann, Annika; Landwehrt, Julia; Krumova, Elena K; Ocklenburg, Sebastian; Güntürkün, Onur; Maier, Christoph

    2012-11-01

    Recently, a shift of the visual subjective body midline (vSM), a correlate of the egocentric reference frame, towards the affected side was reported in patients with complex regional pain syndrome (CRPS). However, the specificity of this finding is as yet unclear. This study compares 24 CRPS patients to 21 patients with upper limb pain of other origin (pain control) and to 24 healthy subjects using a comprehensive test battery, including assessment of the vSM in light and dark, line bisection, hand laterality recognition, neglect-like severity symptoms, and motor impairment (disability of the arm, shoulder, and hand). 1-way analysis of variance, t-tests, significance level: 0.05. In the dark, CRPS patients displayed a significantly larger leftward spatial bias when estimating their vSM, compared to pain controls and healthy subjects, and also reported lower motor function than pain controls. For right-affected CRPS patients only, the deviation of the vSM correlated significantly with the severity of distorted body perception. Results confirm previous findings of impaired visuospatial perception in CRPS patients, which might be the result of the involvement of supraspinal mechanisms in this pain syndrome. These mechanisms might accentuate the leftward bias that results from a right-hemispheric dominance in visuospatial processing and is known as pseudoneglect. Pseudoneglect reveals itself in the tendency to perceive the midpoint of horizontal lines or the subjective body midline left of the centre. It was observable in all 3 groups, but most pronounced in CRPS patients, which might be due to the cortical reorganisation processes associated with this syndrome. Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  17. Projected Effect of Increased Active Travel in German Urban Regions on the Risk of Type 2 Diabetes

    Science.gov (United States)

    Brinks, Ralph; Hoyer, Annika; Kuss, Oliver; Rathmann, Wolfgang

    2015-01-01

    Background Future transportation policy is likely to reduce emissions in the cities and urban regions by strengthening active travel. Increased walking and cycling are known to have positive effects on health outcomes. This work estimates effects of increased active travel on type 2 diabetes in Germany, where 64% of the population live in urban regions. Methods Based on the effect size of an increased active travel scenario reported from a recent meta-analysis, we project the change in the life time risk, the proportion of prevented cases and the change in diabetes free life time in a German birth cohort (born 1985) compared to business as usual. Results The absolute risk reduction of developing type 2 diabetes before the age of 80 is 6.4% [95% confidence interval: 3.7-9.7%] for men and 4.7% [2.2-7.7%] for women, respectively. Compared to business as usual, the increased active travel scenario prevents 14.0% [8.1-21.2%] of the future cases of diabetes in men and 15.8% [9.3-23.1%] in women. Diabetes free survival increases by 1.7 [1.0-2.7] years in men and 1.4 [0.6-2.3] in women. Conclusions Our projection predicts a substantial impact of increased active travel on the future burden of type 2 diabetes. The most striking effect may be seen in the number of prevented cases. In all urban regions with an increased active travel transport policy, about one out of seven male and one out of six female cases can be prevented. PMID:25849819

  18. Projected effect of increased active travel in German urban regions on the risk of type 2 diabetes.

    Directory of Open Access Journals (Sweden)

    Ralph Brinks

    Full Text Available Future transportation policy is likely to reduce emissions in the cities and urban regions by strengthening active travel. Increased walking and cycling are known to have positive effects on health outcomes. This work estimates effects of increased active travel on type 2 diabetes in Germany, where 64% of the population live in urban regions.Based on the effect size of an increased active travel scenario reported from a recent meta-analysis, we project the change in the life time risk, the proportion of prevented cases and the change in diabetes free life time in a German birth cohort (born 1985 compared to business as usual.The absolute risk reduction of developing type 2 diabetes before the age of 80 is 6.4% [95% confidence interval: 3.7-9.7%] for men and 4.7% [2.2-7.7%] for women, respectively. Compared to business as usual, the increased active travel scenario prevents 14.0% [8.1-21.2%] of the future cases of diabetes in men and 15.8% [9.3-23.1%] in women. Diabetes free survival increases by 1.7 [1.0-2.7] years in men and 1.4 [0.6-2.3] in women.Our projection predicts a substantial impact of increased active travel on the future burden of type 2 diabetes. The most striking effect may be seen in the number of prevented cases. In all urban regions with an increased active travel transport policy, about one out of seven male and one out of six female cases can be prevented.

  19. Regional Quantitative Cover Mapping of Tundra Plant Functional Types in Arctic Alaska

    Directory of Open Access Journals (Sweden)

    Matthew J. Macander

    2017-10-01

    Full Text Available Ecosystem maps are foundational tools that support multi-disciplinary study design and applications including wildlife habitat assessment, monitoring and Earth-system modeling. Here, we present continuous-field cover maps for tundra plant functional types (PFTs across ~125,000 km2 of Alaska’s North Slope at 30-m resolution. To develop maps, we collected a field-based training dataset using a point-intercept sampling method at 225 plots spanning bioclimatic and geomorphic gradients. We stratified vegetation by nine PFTs (e.g., low deciduous shrub, dwarf evergreen shrub, sedge, lichen and summarized measurements of the PFTs, open water, bare ground and litter using the cover metrics total cover (areal cover including the understory and top cover (uppermost canopy or ground cover. We then developed 73 spectral predictors derived from Landsat satellite observations (surface reflectance composites for ~15-day periods from May–August and five gridded environmental predictors (e.g., summer temperature, climatological snow-free date to model cover of PFTs using the random forest data-mining algorithm. Model performance tended to be best for canopy-forming PFTs, particularly deciduous shrubs. Our assessment of predictor importance indicated that models for low-statured PFTs were improved through the use of seasonal composites from early and late in the growing season, particularly when similar PFTs were aggregated together (e.g., total deciduous shrub, herbaceous. Continuous-field maps have many advantages over traditional thematic maps, and the methods described here are well-suited to support periodic map updates in tandem with future field and Landsat observations.

  20. Efficient n-type doping of CdTe epitaxial layers grown by photo-assisted molecular beam epitaxy with the use of chlorine

    Energy Technology Data Exchange (ETDEWEB)

    Hommel, D.; Scholl, S.; Kuhn, T.A.; Ossau, W.; Waag, A.; Landwehr, G. (Univ. Wuerzburg, Physikalisches Inst. (Germany)); Bilger, G. (Univ. Stuttgart, Inst. fuer Physikalische Elektronik (Germany))

    1993-01-30

    Chlorine has been used successfully for the first time for n-type doping of CdTe epitaxial layers (epilayers) grown by photo-assisted molecular beam epitaxy. Similar to n-type doping of ZnSe layers, ZnCl[sub 2] has been used as source material. The free-carrier concentration can be varied over more than three orders of magnitude by changing the ZnCl[sub 2] oven temperature. Peak mobilities are 4700 cm[sup 2] V[sup -1] s[sup -1] for an electron concentration of 2x10[sup 16] cm[sup -3] and 525 cm[sup 2] V[sup -1] s[sup -1] for 2x10[sup 18] cm[sup -3]. The electrical transport data obtained by Van der Pauw configuration and Hall structure measurements are consistent with each other, indicating a good uniformity of the epilayers. In photoluminescence the donor-bound-exciton emission dominates for all chlorine concentrations. This contasts significantly with results obtained for indium doping, commonly used for obtaining n-type CdTe epilayers. The superiority of chlorine over indium doping and the influence of growth parameters on the behaviour of CdTe:Cl layers will be discussed on the basis of transport, luminescence, secondary ion mass spectroscopy and X-ray photoelectron spectroscopy data. (orig.).

  1. Air-assisted dispersive liquid-liquid microextraction based on a new hydrophobic deep eutectic solvent for the preconcentration of benzophenone-type UV filters from aqueous samples.

    Science.gov (United States)

    Ge, Dandan; Zhang, Yi; Dai, Yixiu; Yang, Shumin

    2018-04-01

    Deep eutectic solvents are considered as new and green solvents that can be widely used in analytical chemistry such as microextraction. In the present work, a new dl-menthol-based hydrophobic deep eutectic solvent was synthesized and used as extraction solvents in an air-assisted dispersive liquid-liquid microextraction method for preconcentration and extraction of benzophenone-type UV filters from aqueous samples followed by high-performance liquid chromatography with diode array detection. In an experiment, the deep eutectic solvent formed by dl-menthol and decanoic acid was added to an aqueous solution containing the UV filters, and then the mixture was sucked up and injected five times by using a glass syringe, and a cloudy state was achieved. After extraction, the solution was centrifuged and the upper phase was subjected to high-performance liquid chromatography for analysis. Various parameters such as the type and volume of the deep eutectic solvent, number of pulling, and pushing cycles, solution pH and salt concentration were investigated and optimized. Under the optimum conditions, the developed method exhibited low limits of detection and limits of quantitation, good linearity, and precision. Finally, the proposed method was successfully applied to determine the benzophenone-type filters in environmental water samples with relative recoveries of 88.8-105.9%. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Geomorphology and Geology of the Southwestern Margaritifer Sinus and Argyre Regions of Mars. Part 3: Valley Types and Distribution

    Science.gov (United States)

    Parker, T. J.; Pieri, D. C.

    1985-01-01

    Three major valley tapes were identified in the SW Margaritefer Sinus and Argyre regions. Two are restricted to specific geologic units while the third is independent of the geology. The first type (the small valley networks) are found within the channeled and subdued plains unit in the eastern half of the map, in the grooved and channeled plains unit north of Nirgal Vallis, and in scattered instances in the cratered plateau unit north of Argyre. The even smaller valleys just inside Argyre's rim and on the inner slopes of many large craters are not directly related to the processes which formed the small valleys but are a result, instead, of post-impact modification of the crater walls. The second type of valley network is represented by Nirgal Vallis and the similar, shorter continuation of it to the west. This type is found only in the smooth plains material west of Uzboi Vallis in the map area. The third type of valley network is that of the Uzbol-Holden-Ladon valles system. This system is related to catastrophic outflow from Argyre Basin and is topographically rather than geologically controlled.

  3. Detection and Localization of Robotic Tools in Robot-Assisted Surgery Videos Using Deep Neural Networks for Region Proposal and Detection.

    Science.gov (United States)

    Sarikaya, Duygu; Corso, Jason J; Guru, Khurshid A

    2017-07-01

    Video understanding of robot-assisted surgery (RAS) videos is an active research area. Modeling the gestures and skill level of surgeons presents an interesting problem. The insights drawn may be applied in effective skill acquisition, objective skill assessment, real-time feedback, and human-robot collaborative surgeries. We propose a solution to the tool detection and localization open problem in RAS video understanding, using a strictly computer vision approach and the recent advances of deep learning. We propose an architecture using multimodal convolutional neural networks for fast detection and localization of tools in RAS videos. To the best of our knowledge, this approach will be the first to incorporate deep neural networks for tool detection and localization in RAS videos. Our architecture applies a region proposal network (RPN) and a multimodal two stream convolutional network for object detection to jointly predict objectness and localization on a fusion of image and temporal motion cues. Our results with an average precision of 91% and a mean computation time of 0.1 s per test frame detection indicate that our study is superior to conventionally used methods for medical imaging while also emphasizing the benefits of using RPN for precision and efficiency. We also introduce a new data set, ATLAS Dione, for RAS video understanding. Our data set provides video data of ten surgeons from Roswell Park Cancer Institute, Buffalo, NY, USA, performing six different surgical tasks on the daVinci Surgical System (dVSS) with annotations of robotic tools per frame.

  4. Essential Oils Extracted Using Microwave-Assisted Hydrodistillation from Aerial Parts of Eleven Artemisia Species: Chemical Compositions and Diversities in Different Geographical Regions of Iran

    Directory of Open Access Journals (Sweden)

    Majid Mohammadhosseini

    2017-03-01

    Full Text Available This study aimed to assess the chemical compositions of essential oils (EOs extracted through microwave-assisted hydrodistillation from aerial parts of 11 Artemisia species growing wild in different regions in Northern, Eastern, Western, and Central parts of Iran. The EOs were subsequently analyzed via GC and GC-MS. The percentage yields of the EOs varied over the range of 0.21-0.50 (w/w%. On the basis of these characterizations and spectral assignments, natural compounds including camphor, 1,8-cineole, camphene, α-pinene, β-pinene, β-thujone, and sabinene were the most abundant and frequent constituents among all studied chemical profiles. Accordingly, oxygenated monoterpenes, monoterpene hydrocarbons, and non-terpene hydrocarbons were the dominant groups of natural compounds in the chemical profiles of 13, 4, and 2 samples, respectively. Moreover, five chemotypes were identified using statistical analyses: camphene, α-pinene and β-pinene; 1,8-cineole; camphore and 1,8-cineole; camphore and camphore and β-thujone.

  5. Studies on the Extraction Region of the Type VI RF Driven H- Ion Source

    Science.gov (United States)

    McNeely, P.; Bandyopadhyay, M.; Franzen, P.; Heinemann, B.; Hu, C.; Kraus, W.; Riedl, R.; Speth, E.; Wilhelm, R.

    2002-11-01

    vicinity of the peak of the external magnetic filter field) and changes to source parameters as a function of power, and argon addition are reported. The behaviour of the electron density is different when the plasma is argon seeded showing a strong increase with RF power. The plasma potential is decreased by 2 V when argon is added to the plasma. The effect of the presence of unwanted silver sputtered from the Faraday screen by Ar+ ions on both the source performance and the plasma parameters is also presented. The silver dramatically downgraded source performance in terms of current density and produced an early saturation of current with applied RF power. Recently, collaboration was begun with the Technical University of Augsburg to perform spectroscopic measurements on the Type VI ion source. The final results of this analysis are not yet ready but some interesting initial observations on the gas temperature, disassociation degree and impurity ions will be presented.

  6. Ecosystem CO2 production during winter in a Swedish subarctic region: the relative importance of climate and vegetation type

    DEFF Research Database (Denmark)

    Grogan, Paul; Jonasson, Sven Evert

    2006-01-01

    General circulation models consistently predict that regional warming will be most rapid in the Arctic, that this warming will be predominantly in the winter season, and that it will often be accompanied by increasing snowfall. Paradoxically, despite the strong cold season emphasis in these predi...... will respond to climate change during winter because they indicate a threshold (~1 m) above which there would be little effect of increased snow accumulation on wintertime biogeochemical cycling....... in these predictions, we know relatively little about the plot and landscape-level controls on tundra biogeochemical cycling in wintertime as compared to summertime. We investigated the relative influence of vegetation type and climate on CO2 production rates and total wintertime CO2 release in the Scandinavian...... subarctic. Ecosystem respiration rates and a wide range of associated environmental and substrate pool size variables were measured in the two most common vegetation types of the region (birch understorey and heath tundra) at four paired sites along a 50 km transect through a strong snow depth gradient...

  7. Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose.

    Directory of Open Access Journals (Sweden)

    Rosemary C Challis

    Full Text Available We recently reported that olfactory sensory neurons in the dorsal zone of the mouse olfactory epithelium exhibit drastic location-dependent differences in cilia length. Furthermore, genetic ablation of type III adenylyl cyclase (ACIII, a key olfactory signaling protein and ubiquitous marker for primary cilia, disrupts the cilia length pattern and results in considerably shorter cilia, independent of odor-induced activity. Given the significant impact of ACIII on cilia length in the dorsal zone, we sought to further investigate the relationship between cilia length and ACIII level in various regions throughout the mouse olfactory epithelium. We employed whole-mount immunohistochemical staining to examine olfactory cilia morphology in phosphodiesterase (PDE 1C-/-;PDE4A-/- (simplified as PDEs-/- hereafter and ACIII-/- mice in which ACIII levels are reduced and ablated, respectively. As expected, PDEs-/- animals exhibit dramatically shorter cilia in the dorsal zone (i.e., where the cilia pattern is found, similar to our previous observation in ACIII-/- mice. Remarkably, in a region not included in our previous study, ACIII-/- animals (but not PDEs-/- mice have dramatically elongated, comet-shaped cilia, as opposed to characteristic star-shaped olfactory cilia. Here, we reveal that genetic ablation of ACIII has drastic, location-dependent effects on cilia architecture in the mouse nose. These results add a new dimension to our current understanding of olfactory cilia structure and regional organization of the olfactory epithelium. Together, these findings have significant implications for both cilia and sensory biology.

  8. Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex

    DEFF Research Database (Denmark)

    Viken, M.K.; Blomhoff, A.; Olsson, M.

    2009-01-01

    parent homozygous for these loci, were genotyped for 137 polymorphisms. We found novel associations on the DRB1(*)0401-DQA1(*)03-DQB1(*)0302 haplotypic background with eight single nucleotide polymorphisms (SNPs) located within or near the PRSS16 gene. In addition, association at the butyrophilin (BTN......(*)03-DQA1(*)0501-DQB1(*)0201 haplotype, and this study aimed to fine-map the associated region also on the DRB1(*)0401-DQA1(*)03-DQB1(*)0302 haplotype, characterized by less extensive linkage disequilibrium. To exclude associations secondary to DRB1-DQA1-DQB1 haplotypes, 205 families with at least one......)-gene cluster, particularly the BTN3A2 gene, was observed by multilocus analyses. We replicated the associations with SNPs in the PRSS16 region and, albeit weaker, to the BTN3A2 region, in an independent material of 725 families obtained from the Type 1 Diabetes Genetics Consortium. It is important to note...

  9. Regional differences of undiagnosed type 2 diabetes and prediabetes prevalence are not explained by known risk factors.

    Directory of Open Access Journals (Sweden)

    Teresa Tamayo

    Full Text Available We have previously found regional differences in the prevalence of known type 2 diabetes between northeastern and southern Germany. We aim to also provide prevalence estimates for prediabetes (isolated impaired fasting glucose (i-IFG, isolated glucose intolerance (i-IGT, combined IFG and IGT and unknown type 2 diabetes for both regions.Prevalence (95%CI of prediabetes (i-IFG: fasting glucose 5.6-6.9 mmol/l; i-IGT: 2 h postchallenge glucose 7.8-11.0 mmol/l, oral glucose tolerance test (OGTT, ≥ 8 h overnight fasting and unknown diabetes were analyzed in two regional population-based surveys (age group 35-79 years: SHIP-TREND (Study of Health in Pomerania (northeast, 2008-2012 and KORA F4 (Cooperative Health Research in the region of Augsburg (south, 2006-2008. Both studies used similar methods, questionnaires, and identical protocols for OGTT. Overall, 1,980 participants from SHIP-TREND and 2,617 participants from KORA F4 were included.Age-sex-standardized prevalence estimates (95%CI of prediabetes and unknown diabetes were considerably higher in the northeast (SHIP-TREND: 43.1%; 40.9-45.3% and 7.1%; 5.9-8.2% than in the south of Germany (KORA F4: 30.1%; 28.4-31.7% and 3.9%; 3.2-4.6%, respectively. In particular, i-IFG (26.4%; 24.5-28.3% vs. 17.2%; 15.7-18.6% and IFG+IGT (11.2%; 9.8-12.6% vs. 6.6%; 5.7-7.5% were more frequent in SHIP-TREND than in KORA. In comparison to normal glucose tolerance, the odds of having unknown diabetes (OR, 95%CI: 2.59; 1.84-3.65 or prediabetes (1.98; 1.70-2.31 was higher in the northeast than in the south after adjustment for known risk factors (obesity, lifestyle.The regional differences of prediabetes and unknown diabetes are in line with the geographical pattern of known diabetes in Germany. The higher prevalences in the northeast were not explained by traditional risk factors.

  10. A Framework to Assist Health Professionals in Recommending High-Quality Apps for Supporting Chronic Disease Self-Management: Illustrative Assessment of Type 2 Diabetes Apps.

    Science.gov (United States)

    Hale, Kelli; Capra, Sandra; Bauer, Judith

    2015-09-14

    This paper presents an approach to assist health professionals in recommending high quality apps for supporting chronic disease self-management. Most app reviews focus on popularity, aesthetics, functionality, usability, and information quality. There is no doubt these factors are important in selecting trustworthy apps which are appealing to users, but behavioral theory may be also be useful in matching the apps to user needs. The framework developed aims to be methodologically sound, capable of selecting popular apps which include content covered by evidence-based programs, consistent with behavioral theory, as well as a patient-centered approach for matching apps to patients' individual needs. A single disease-type 2 diabetes-was selected to illustrate how the framework can be applied as this was deemed to represent the types of strategies used in many chronic diseases. A systematic approach based on behavioral theory and recommendations from best practice guidelines was developed for matching apps to patients' needs. In March 2014, a series of search strategies was used to identify top-rated iPhone and Android health apps, representing 29 topics from five categories of type 2 diabetes self-management strategies. The topics were chosen from published international guidelines for the management of diabetes. The senior author (KH) assessed the most popular apps found that addressed these topics using the Behavioral Theory Content Survey (BTS), which is based on traditional behavioral theory. A tool to assist decision making when using apps was developed and trialed with health professionals for ease of use and understanding. A total of 14 apps were assessed representing all five topic categories of self-management. Total theoretical scores (BTS scores) were less than 50 on a 100-point scale for all apps. Each app scored less than 50% of the total possible BTS score for all four behavioral theories and for most of the 20 behavioral strategies; however, apps scored

  11. Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11

    Directory of Open Access Journals (Sweden)

    Barratt Bryan J

    2007-05-01

    Full Text Available Abstract Background In an effort to locate susceptibility genes for type 1 diabetes (T1D several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined analysis of the main linkage scans. Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D. Results Initially, we resequenced the functional candidate genes, CREM and SDF1, located in this region, genotyped 13 tag single nucleotide polymorphisms (SNPs and found no association with T1D. We then undertook analysis of the whole 23 Mb region. We constructed and sequenced a contig tile path from two bacterial artificial clone libraries. By comparison with a clone library from an unrelated person used in the Human Genome Project, we identified 12,058 SNPs. We genotyped 303 SNPs and 25 polymorphic microsatellite markers in 765 multiplex T1D families and followed up 22 associated polymorphisms in up to 2,857 families. We found nominal evidence of association in six loci (P = 0.05 – 0.0026, located near the PAPD1 gene. Therefore, we resequenced 38.8 kb in this region, found 147 SNPs and genotyped 84 of them in the T1D families. We also tested 13 polymorphisms in the PAPD1 gene and in five other loci in 1,612 T1D patients and 1,828 controls from the UK. Overall, only the D10S193 microsatellite marker located 28 kb downstream of PAPD1 showed nominal evidence of association in both T1D families and in the case-control sample (P = 0.037 and 0.03, respectively. Conclusion We conclude that polymorphisms in the CREM and SDF1 genes have no major effect on T1D. The weak T1D association that we detected in the association scan near the PAPD1 gene may be either false or due to a small genuine effect, and cannot explain linkage at the IDDM10 region.

  12. Tuning Bandgap of p-Type Cu2Zn(Sn, Ge)(S, Se)4 Semiconductor Thin Films via Aqueous Polymer-Assisted Deposition.

    Science.gov (United States)

    Yi, Qinghua; Wu, Jiang; Zhao, Jie; Wang, Hao; Hu, Jiapeng; Dai, Xiao; Zou, Guifu

    2017-01-18

    Bandgap engineering of kesterite Cu 2 Zn(Sn, Ge)(S, Se) 4 with well-controlled stoichiometric composition plays a critical role in sustainable inorganic photovoltaics. Herein, a cost-effective and reproducible aqueous solution-based polymer-assisted deposition approach is developed to grow p-type Cu 2 Zn(Sn, Ge)(S, Se) 4 thin films with tunable bandgap. The bandgap of Cu 2 Zn(Sn, Ge)(S, Se) 4 thin films can be tuned within the range 1.05-1.95 eV using the aqueous polymer-assisted deposition by accurately controlling the elemental compositions. One of the as-grown Cu 2 Zn(Sn, Ge)(S, Se) 4 thin films exhibits a hall coefficient of +137 cm 3 /C. The resistivity, concentration and carrier mobility of the Cu 2 ZnSn(S, Se) 4 thin film are 3.17 ohm·cm, 4.5 × 10 16 cm -3 , and 43 cm 2 /(V·S) at room temperature, respectively. Moreover, the Cu 2 ZnSn(S, Se) 4 thin film when used as an active layer in a solar cell leads to a power conversion efficiency of 3.55%. The facile growth of Cu 2 Zn(Sn, Ge)(S, Se) 4 thin films in an aqueous system, instead of organic solvents, provides great promise as an environmental-friendly platform to fabricate a variety of single/multi metal chalcogenides for the thin film industry and solution-processed photovoltaic devices.

  13. Supporting Regional Aged Care Nursing Staff to Manage Residents' Behavioural and Psychological Symptoms of Dementia, in Real Time, Using the Nurses' Behavioural Assistant (NBA): A Pilot Site 'End-User Attitudes' Trial.

    Science.gov (United States)

    Klein, Britt; Clinnick, Lisa; Chesler, Jessica; Stranieri, Andrew; Bignold, Adam; Dazeley, Richard; McLaren, Suzanne; Lauder, Sue; Balasubramanian, Venki

    2018-01-01

    This regional pilot site 'end-user attitudes' study explored nurses' experiences and impressions of using the Nurses' Behavioural Assistant (NBA) (a knowledge-based, interactive ehealth system) to assist them to better respond to behavioural and psychological symptoms of dementia (BPSD) and will be reported here. Focus groups were conducted, followed by a four-week pilot site 'end-user attitudes' trial of the NBA at a regional aged care residential facility (ACRF). Brief interviews were conducted with consenting nursing staff. Focus group feedback (N = 10) required only minor cosmetic changes to the NBA prototype. Post pilot site end-user interview data (N = 10) indicated that the regional ACRF nurses were positive and enthusiastic about the NBA, however several issues were also identified. Overall the results supported the utility of the NBA to promote a person centred care approach to managing BPSD. Slight modifications may be required to maximise its uptake across all ACRF nursing staff.

  14. Economic impacts from energy efficiency programs - Variations in multiplier effects by program type and region. Volume 1

    International Nuclear Information System (INIS)

    Gardner, John; Skumatz, Lisa

    2007-01-01

    Research indicates that the value of omitted program effects - specifically non-energy benefits (NEBs) - represent a significant share of overall program impacts. One of the largest components of societal benefits is the direct and indirect economic and job creation effects stimulated by the investment in conservation on behalf of the program. The literature has indicated that the valuations assigned to this category of these categories can be large, but much of the literature overstates the impact of economic NEBs. We conducted extensive research to develop reliable and defensible estimates of these benefits categories. This study used input-output analysis to update the economic multipliers for NEBs in several ways. Net: Developed 'net' estimates of the multipliers (rather than 'gross' factors)Variations by Region: Estimated multipliers for multiple states and for the entire US; Variations by Program Type: Developed estimates based on different types or categories of programs (e.g weatherization vs. new construction vs. appliance programs, etc.), Variations in Baseline Assumptions: Different assumptions about where the expenditures are transferred 'from' for the net analysis (e.g. from 'generation', from a mixed market basket, etc.); and Variations over Time: Used data from multiple time periods to examine changes in the size of multipliers over time. We examined the results by state, by program type, and over time and found dramatic differences in the economic impacts by program type and territory under consideration. The results provide estimates of the economic impacts derived from the program; however, for communities or utilities with economic development goals, the results can be used to help select between program alternatives. The results are new, and the revised figures have been used to compute more reliable and tailored estimates of economic non-energy benefits that can be applied in regulatory tests

  15. GP-support by means of AGnES-practice assistants and the use of telecare devices in a sparsely populated region in Northern Germany – proof of concept

    Directory of Open Access Journals (Sweden)

    Scriba Sibylle

    2009-06-01

    Full Text Available Abstract Background In many rural regions in Germany, the proportion of the elderly population increases rapidly. Simultaneously, about one-third of the presently active GPs will retire until 2010. Often it is difficult to find successors for vacant GP-practices. These regions require innovative concepts to avoid the imminent shortage in primary health care. The AGnES-concept comprises the delegation of GP-home visits to qualified AGnES-practice assistants (AGnES: GP-supporting, community-based, e-health-assisted, systemic intervention. Main objectives were the assessment of the acceptance of the AGnES-concept by the participating GPs, patients, and AGnES-practice assistants, the kind of delegated tasks, and the feasibility of home telecare in a GP-practice. Methods In this paper, we report first results of the implementation of this concept in regular GP-practices, conducted November 2005 – March 2007 on the Island of Rügen, Mecklenburg-Western Pomerania, Germany. This study was meant as a proof of concept. The GP delegated routine home-visits to qualified practice employees (here: registered nurses. Eligible patients were provided with telecare-devices to monitor disease-related physiological values. All delegated tasks, modules conducted and questionnaire responses were documented. The participating patients were asked for their acceptance based on standardized questionnaires. The GPs and AGnES-practice assistants were asked for their judgement about different project components, the quality of health care provision and the competences of the AGnES-practice assistants. Results 550 home visits were conducted. 105 patients, two GPs and three AGnES-practice assistants (all registered nurses participated in the project. 48 patients used telecare-devices to monitor health parameters. 87.4% of the patients accepted AGnES-care as comparable to common GP-care. In the course of the project, the GPs delegated an increasing number of both monitoring

  16. [Characteristics of soil moisture variation in different land use types in the hilly region of the Loess Plateau, China].

    Science.gov (United States)

    Tang, Min; Zhao, Xi Ning; Gao, Xiao Dong; Zhang, Chao; Wu, Pu Te

    2018-03-01

    Soil water availability is a key factor restricting the ecological construction and sustainable land use in the loess hilly region. It is of great theoretical and practical significance to understand the soil moisture status of different land use types for the vegetation restoration and the effective utilization of land resources in this area. In this study, EC-5 soil moisture sensors were used to continuously monitor the soil moisture content in the 0-160 cm soil profile in the slope cropland, terraced fields, jujube orchard, and grassland during the growing season (from May to October) in the Yuanzegou catchment on the Loess Plateau, to investigate soil moisture dynamics in these four typical land use types. The results showed that there were differences in seasonal variation, water storage characteristics, and vertical distribution of soil moisture under different land use types in both the normal precipitation (2014) and dry (2015) years. The terraced fields showed good water retention capacity in the dry year, with the average soil moisture content of 0-60 cm soil layer in the growing season being 2.6%, 4.2%, and 1.8% higher than that of the slope cropland, jujube orchard, and grassland (all Pmoisture content of 0-60 cm soil layer in jujube orchard in the growing season was 2.9%, 3.8%, and 4.5% lower than that of slope cropland, terraced fields, and grassland, respectively (all Pmoisture in the surface layer (0-20 cm) and soil moisture in the middle layer (20-100 cm) under different land use types was large, and the trend for the similarity degree of soil moisture variation followed terraced fields > grassland > slope cropland > jujube orchard. The slope cropland in this area could be transformed into terraced fields to improve the utilization of precipitation and promote the construction of ecological agriculture. Aiming at resolving the severe water shortage in the rain-fed jujube orchard for the sustainable development of jujube orchard in the loess hilly

  17. Increased endothelin-1 and diminished nitric oxide levels in blister fluids of patients with intermediate cold type complex regional pain syndrome type 1

    Directory of Open Access Journals (Sweden)

    Niehof Sjoerd

    2006-11-01

    Full Text Available Abstract Background In complex regional pain syndrome type 1 (CRPS1 pro-inflammatory mediators and vascular changes play an important role in the sustained development and outcome of the disease. The aim of this study was to determine the involvement of vasoactive substances endothelin-1 (ET-1 and nitric oxide (NO during early chronic CRPS1. Methods Included were 29 patients with CRPS 1 who were diagnosed during the acute stage of their disease and observed during follow-up visits. Disease activity and impairment were determined and artificial suction blisters were made on the CRPS1 and the contralateral extremities for measurements of IL-6, TNF-α, ET-1 and nitrate/nitrite (NOx. Results The levels of IL-6, TNF-α and ET-1 in blister fluid in the CRPS1 extremity versus the contralateral extremity were significantly increased and correlated with each other, whereas NOx levels were decreased. Conclusion The NOx/ET-1 ratio appears to be disturbed in the intermediate stage of CRPS, resulting in vasoconstriction and consequently in a diminished tissue blood distribution.

  18. Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells

    Directory of Open Access Journals (Sweden)

    Keppel Hesselink JM

    2013-03-01

    Full Text Available Jan M Keppel Hesselink,1 David J Kopsky21Institute for Neuropathic Pain, Bosch en Duin, The Netherlands; 2Institute for Neuropathic Pain, Amsterdam, The NetherlandsAbstract: Chronic regional pain syndrome (CRPS can be intractable to treat and patients sometimes suffer for many years. Therefore, new treatment strategies are needed to alleviate symptoms in CRPS patients. This case report describes a patient suffering from intractable CRPS type 1 for 13 years. Due to her swollen painful feet and left knee she is wheelchair-bound. The combination of palmitoylethanolamide and ketamine 10% cream reduced her pain by more than 50% after 1 month of treatment, and a marked reduction in swelling and skin discoloration was noticed. Furthermore, she could walk independently again and she experienced no side effects. Thus, palmitoylethanolamide and topical ketamine could be a combination therapy option for treating CRPS patients.Keywords: palmitoylethanolamide, ketamine, cream, CRPS, endocannabinoid, sudeck, mast cells

  19. Prediction of a new region in the H-T phase diagram of a disordered type II superconductor

    International Nuclear Information System (INIS)

    Nandgaonkar, Ajay; Kanhere, D.G.; Trivedi, Nandini

    1997-01-01

    The phase diagram of a type II superconductor (SC) in the magnetic field (B) - temperature (T) plane is shown schematically. At low T the system consists of an Abrikosov triangular vortex lattice which melts as the temperature is increased. At high B, the rigidity of the vortex lattice C 66 decreases with increasing B. Thus, the melting curve essentially tracks the H c2 behaviour, as shown in region (a) in fig. It was further suggested by Nelson, based on a mapping of vortices in 3D onto a problem of boson world-lines in spatial 2D and 1 imaginary dimension, that the classical statistical mechanics of vortices is analogous to the problem of quantum melting of the bosons. He used this mapping to predict a novel reentrant behavior of the phase boundary. These predictions were verified by experiments

  20. ANALYSIS OF EPIDEMIOLOGICAL INDICATORS OF TYPE 1 DIABETES ACCORDING TO THE REGISTER OF TOMSK AND TOMSK REGION

    Directory of Open Access Journals (Sweden)

    Yu. G. Samoilova

    2014-01-01

    Full Text Available Type 1 diabetes mellitus (T1DM is a serious medical and social problem in the whole world. Despite the presence of a large amount of accumulated knowledge to control the disease, there are methodological limitations and uncertainties of the register. In order to obtain complete information on the prevalence and incidence of T1DM among children and adolescents in order to monitor the disease, providing diagnostic and rehabilitation measures, there was a need for analysis of epidemiological climate T1DM in children and adolescents of the Tomsk region. The evaluation found that T1DM on the rise, especially among young children, which raises the need for а personalized approach in addressing this issue.

  1. Avaliação da assistência farmacêutica básica nos municípios de abrangência da 17ª Coordenadoria Regional de Saúde do Rio Grande do Sul Evaluation of pharmaceutical assistance in cities of the 17th Regional Health Department/Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Carmen L. B. De Bernardi

    2006-04-01

    Full Text Available A aplicação de indicadores para a avaliação das ações desenvolvidas pela Assistência Farmacêutica nos municípios é uma estratégia de organização da atenção e gestão em saúde. O objetivo deste estudo é avaliar a Assistência Farmacêutica Básica, através de indicadores, nos vinte municípios de abrangência da 17ª Coordenadoria Regional de Saúde do Rio Grande do Sul. MÉTODOS: Estudo transversal utilizando indicadores da Assistência Farmacêutica, propostos pela Secretaria de Saúde do Estado do Rio Grande do Sul (SES/RS, em cada Secretaria Municipal de Saúde dos 20 municípios que compõem a 17ª Coordenadoria Regional de Saúde de Ijuí/RS. Em cada município foi entrevistado o responsável pela farmácia. RESULTADOS: Apenas cinco municípios tinham farmacêutico responsável pela farmácia. Participaram de algum tipo de capacitação, 25% dos trabalhadores. Apenas 15% dos municípios tinham a Relação de Medicamentos Básicos afixada em local visível. O controle de estoque de medicamentos foi seguido por 90% dos municípios. Quanto aos medicamentos marcadores, 78% estavam disponíveis. O número médio de medicamentos por prescrição foi de 2,0. Dos prescritos, 76% pertenciam à Relação de Medicamentos Básicos, e 64% utilizaram a Denominação Comum Brasileira e/ou a Denominação Comum Internacional. Foram dispensados 88% dos medicamentos prescritos. CONCLUSÕES: A Assistência Farmacêutica Básica nos municípios é deficitária, exigindo maiores investimentos em recursos humanos, físicos e materiais. A ausência do farmacêutico na equipe de saúde é um fator importante, ainda que não o único, da fragmentação da execução, das etapas do ciclo da Assistência Farmacêutica e da baixa eficiência das ações de saúde neste âmbito.The application of indicators to evaluate actions developed by the pharmaceutical assistance in cities is a strategy to organize the attention and management in health. The

  2. Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function.

    Science.gov (United States)

    Wong, S W; Schaffer, P A

    1991-05-01

    Like other DNA-containing viruses, the three origins of herpes simplex virus type 1 (HSV-1) DNA replication are flanked by sequences containing transcriptional regulatory elements. In a transient plasmid replication assay, deletion of sequences comprising the transcriptional regulatory elements of ICP4 and ICP22/47, which flank oriS, resulted in a greater than 80-fold decrease in origin function compared with a plasmid, pOS-822, which retains these sequences. In an effort to identify specific cis-acting elements responsible for this effect, we conducted systematic deletion analysis of the flanking region with plasmid pOS-822 and tested the resulting mutant plasmids for origin function. Stimulation by cis-acting elements was shown to be both distance and orientation dependent, as changes in either parameter resulted in a decrease in oriS function. Additional evidence for the stimulatory effect of flanking sequences on origin function was demonstrated by replacement of these sequences with the cytomegalovirus immediate-early promoter, resulting in nearly wild-type levels of oriS function. In competition experiments, cotransfection of cells with the test plasmid, pOS-822, and increasing molar concentrations of a competitor plasmid which contained the ICP4 and ICP22/47 transcriptional regulatory regions but lacked core origin sequences resulted in a significant reduction in the replication efficiency of pOS-822, demonstrating that factors which bind specifically to the oriS-flanking sequences are likely involved as auxiliary proteins in oriS function. Together, these studies demonstrate that trans-acting factors and the sites to which they bind play a critical role in the efficiency of HSV-1 DNA replication from oriS in transient-replication assays.

  3. Heavy Metal Contamination in the Sediments of Anzali International Wetland, Northern Iran Based on Type Regional Development

    Directory of Open Access Journals (Sweden)

    Saeed Ganjali

    2016-08-01

    Full Text Available Background: The most important factors and problems threatening the Anzali Wetland are the contaminant load and sediments entering the wetland, as well as lack of an integrated management plan for this wetland. The main objectives of the current research were to explore whether there are significant differences in concentrations of Zn, Cd, and Pb in surface sediments among different sites (based on type region development of the Anzali Wetland, Northern Iran. Methods: Through a field study, samples were collected from 10 stations based on the type of regional development and contaminant source inputs of Anzali Wetland in 2015. Using a hot-block digester, the sediment samples were digested with a 4:1 combination of nitric acid (HNO3 and perchloric acid (HCLO4 for one hour at 40 °C, followed by 3 h at 140 °C. Afterwards, samples were filtered with Whatman 42, filter paper and the filtrate was kept in polyethylene containers at 4 °C, until analysis by atomic absorption spectrometry (AAS. Results: Mean ± SD levels of metals in the sediments of different stations were 26.7 ± 3.49 (lead, 4.36 ± 0.47 (cadmium, and 88.44 ± 10.06 (zinc μg g-1 dw. There was a significant difference between the stations of the wetland (P < 0.05. This difference could be due to the variations in the input of contaminant sources into the Anzali Wetland. Conclusions: The areas, affected by urban and industrial developments, had the highest level of contamination while the agricultural and less-developed areas had the lowest level of contamination, and therefore, protective plans must be implemented in developed areas in order to lower the level of heavy metals.

  4. River terrace development in the NE Mediterranean region (Syria and Turkey): Patterns in relation to crustal type

    Science.gov (United States)

    Bridgland, David R.; Demir, Tuncer; Seyrek, Ali; Daoud, Mohamad; Abou Romieh, Mohammad; Westaway, Rob

    2017-06-01

    It is widely recognized that the optimal development of river terraces globally has been in the temperate latitudes, with NW and Central Europe being areas of particular importance for the preservation of such archives of Quaternary environmental change. There is also a growing consensus that the principal drivers of terrace formation have been climatic fluctuation against a background of progressive (but variable) uplift. Nonetheless river terraces are widely preserved in the Mediterranean region, where they have often been attributed to the effects of neotectonic activity, with a continuing debate about the relative significance of fluctuating temperature (glacials-interglacials) and precipitation (pluvials-interpluvials). Research in Syria and southern-central Turkey (specifically in the valleys of the Tigris and Ceyhan in Turkey, the Kebir in Syria and the trans-border rivers Orontes and Euphrates) has underlined the importance of uplift rates in dictating the preservation pattern of fluvial archives and has revealed different patterns that can be related to crustal type. The NE Mediterranean coastal region has experienced unusually rapid uplift in the Late Quaternary. The relation between the Kebir terraces and the staircase of interglacial raised beaches preserved along the Mediterranean coastline of NW Syria reinforces previous conclusions that the emplacement of the fluvial terrace deposits in the Mediterranean has occurred during colder climatic episodes.

  5. Potential Risk Factors for the Onset of Complex Regional Pain Syndrome Type 1: A Systematic Literature Review

    Directory of Open Access Journals (Sweden)

    Tracey Pons

    2015-01-01

    Full Text Available Anaesthetists in the acute and chronic pain teams are often involved in treating Complex Regional Pain Syndromes. Current literature about the risk factors for the onset of Complex Regional Pain Syndrome Type 1 (CRPS 1 remains sparse. This syndrome has a low prevalence, a highly variable presentation, and no gold standard for diagnosis. In the research setting, the pathogenesis of the syndrome continues to be elusive. There is a growing body of literature that addresses efficacy of a wide range of interventions as well as the likely mechanisms that contribute to the onset of CRPS 1. The objective for this systematic search of the literature focuses on determining the potential risk factors for the onset of CRPS 1. Eligible articles were analysed, dated 1996 to April 2014, and potential risk factors for the onset of CRPS 1 were identified from 10 prospective and 6 retrospective studies. Potential risk factors for the onset of CRPS 1 were found to include being female, particularly postmenopausal female, ankle dislocation or intra-articular fracture, immobilisation, and a report of higher than usual levels of pain in the early phases of trauma. It is not possible to draw definite conclusions as this evidence is heterogeneous and of mixed quality, relevance, and weighting strength against bias and has not been confirmed across multiple trials or in homogenous studies.

  6. Treatment of complex regional pain syndrome type 1 in a pediatric patient using the lidocaine patch 5%: a case report

    Directory of Open Access Journals (Sweden)

    Steven G Frost, MD

    2003-09-01

    Full Text Available Background: Successful treatment of complex regional pain syndrome type 1 (CRPS-1 requires a coordinated, multidisciplinary approach. Physical rehabilitation is an important component of long-term treatment. Unfortunately, patients with significant allodynia or hyperalgesia characteristic of CRPS-1 often have difficulty progressing through a physical therapy (PT regimen. In most adults with CRPS-1, the treatment of choice is PO opioids. Objective: This article presents a case report of the use of the lidocaine patch 5%, a targeted peripheral analgesic, in a pediatric patient and its effects on reducing pain, improving the patient's overall attitude, and facilitating compliance with ongoing PT. Results: A 10-year-old girl developed CRPS-1 after arthroscopic surgery for a sprained ankle. Attempts at PT were unsuccessful due to inadequate pain relief from various treatment modalities. Therapy with the lidocaine patch 5% was initiated and resulted in significant pain relief, improvements in the patient's attitude, and progress with PT. Conclusion: This case report of a child with CRPS-1 showed that therapy with lidocaine patch 5% may be efficacious in treating children with pain resulting from CRPS-1, thereby increasing the success of PT. Keywords: complex regional pain syndrome, lidocaine patch 5%, targeted peripheral analgesic, pediatrics

  7. Clinical use of regional Tc-99m-HMPAO uptake in dementia of the Alzheimer type (DAT)

    International Nuclear Information System (INIS)

    Gebhardt, U.; Schmauss, F.; Wagner-Manslau, C.; Buttermann, G.; Zimmer, R.

    1993-01-01

    In 46 patients with dementia of the Alzheimer type (DAT) regional cerebral blood flow (rCBF) was compared with cognitive performance (MMSE, CAMCOG). The cortico-cerebellar ratio (CCR), determined by 99m Tc-HMPAO-SPECT was used as a rCBF-equivalent. In the mild demented group we found a bilateral CCR-reduction parietal posterior, in moderate DAT bilateral temporoparietal and leftsided frontolateral defects were seen. Severe DAT showed an additional perfusion decrease mid frontal. With increasing severity of DAT an asymmetric perfusion occurred in 17/46 patients with accentuated CCR-reduction on the left side (temporal>parietal). High correlations between CCR and MMSE (r≥0.70) existed frontolateral, temporal and parietal in the left hemisphere. Significant associations between CCR and CAMCOG were obtained for language in the left temporal posterior region (r=0.64), for memory task left temporal anterior (r=0.59) and for praxis left parietal posterior (r=0.55). In detecting rCBF abnormalities the sensitivity for all 46 DAT patients was 91% and 70% in the mild cases. (orig.) [de

  8. Remote sensing based crop type mapping and evapotranspiration estimates at the farm level in arid regions of the globe

    Science.gov (United States)

    Ozdogan, M.; Serrat-Capdevila, A.; Anderson, M. C.

    2017-12-01

    Despite increasing scarcity of freshwater resources, there is dearth of spatially explicit information on irrigation water consumption through evapotranspiration, particularly in semi-arid and arid geographies. Remote sensing, either alone or in combination with ground surveys, is increasingly being used for irrigation water management by quantifying evaporative losses at the farm level. Increased availability of observations, sophisticated algorithms, and access to cloud-based computing is also helping this effort. This presentation will focus on crop-specific evapotranspiration estimates at the farm level derived from remote sensing in a number of water-scarce regions of the world. The work is part of a larger effort to quantify irrigation water use and improve use efficiencies associated with several World Bank projects. Examples will be drawn from India, where groundwater based irrigation withdrawals are monitored with the help of crop type mapping and evapotranspiration estimates from remote sensing. Another example will be provided from a northern irrigation district in Mexico, where remote sensing is used for detailed water accounting at the farm level. These locations exemplify the success stories in irrigation water management with the help of remote sensing with the hope that spatially disaggregated information on evapotranspiration can be used as inputs for various water management decisions as well as for better water allocation strategies in many other water scarce regions.

  9. Molecular Strain Typing of Clinical Isolates, Trichophyton rubrum using Non Transcribed Spacer (NTS) Region as a Molecular Marker.

    Science.gov (United States)

    Ramaraj, Vijayakumar; Vijayaraman, Rajyoganandh S; Elavarashi, Elangovan; Rangarajan, Sudha; Kindo, Anupma Jyoti

    2017-05-01

    Dermatophytes are a group of fungi which infect keratinized tissues and causes superficial mycoses in humans and animals. The group comprises of three major genera, Trichophyton , Microsporum and Epidermophyton . Among them Trichophyton rubrum is a predominant anthropophilic fungi which causes chronic infections. Although, the infection is superficial and treatable, reinfection/coinfection causes inflation in the treatment cost. Identifying the source and mode of transmission is essential to prevent its transmission. Accurate discrimination is required to understand the clinical (relapse or reinfection) and epidemiological implications of the genetic heterogeneity of this species. Polymorphism in the Non Transcribed Spacer (NTS) region of ribosomal DNA (rDNA) clusters renders an effective way to discriminate strains among T. rubrum . To carry out the strain typing of the clinical isolates, Trichophyton rubrum using NTS as a molecular marker. Seventy T.rubrum clinical isolates obtained from April-2011-March 2013, from Sri Ramachandra Medical Centre, Chennai, Tamil Nadu, India, were identified by conventional phenotypic methods and included in this prospective study. The isolates were then subjected to Polymerase Chain Reaction (PCR) targeting two subrepeat elements (SREs), TRS-1 and TRS-2 of the NTS region. Strain-specific polymorphism was observed in both subrepeat loci. Total, nine different strains were obtained on combining both TRS-1 and TRS-2, SREs. The outcome has given a strong representation for using NTS region amplification in discriminating the T. rubrum clinical isolates. The method can be adapted as a tool for conducting epidemiology and population based study in T. rubrum infections. This will help in future exploration of the epidemiology of T. rubrum .

  10. VT Regional Development Corporation (RDC)

    Data.gov (United States)

    Vermont Center for Geographic Information — The Department of Economic Development partners with the twelve Regional Development Corporations around the state to provide technical assistance. They can assist...

  11. Natural Type 3/Type 2 Intertypic Vaccine-Related Poliovirus Recombinants with the First Crossover Sites within the VP1 Capsid Coding Region

    DEFF Research Database (Denmark)

    Zhang, Yong; Zhu, Shuangli; Yan, Dongmei

    2010-01-01

    Ten uncommon natural type 3/type 2 intertypic poliovirus recombinants were isolated from stool specimens from nine acute flaccid paralysis case patients and one healthy vaccinee in China from 2001 to 2008.......Ten uncommon natural type 3/type 2 intertypic poliovirus recombinants were isolated from stool specimens from nine acute flaccid paralysis case patients and one healthy vaccinee in China from 2001 to 2008....

  12. Antiallodynic Effects of Bee Venom in an Animal Model of Complex Regional Pain Syndrome Type 1 (CRPS-I).

    Science.gov (United States)

    Lee, Sung Hyun; Lee, Jae Min; Kim, Yun Hong; Choi, Jung Hyun; Jeon, Seung Hwan; Kim, Dong Kyu; Jeong, Hyeon Do; Lee, You Jung; Park, Hue Jung

    2017-09-15

    Neuropathic pain in a chronic post-ischaemic pain (CPIP) model mimics the symptoms of complex regional pain syndrome type I (CRPS I). The administration of bee venom (BV) has been utilized in Eastern medicine to treat chronic inflammatory diseases accompanying pain. However, the analgesic effect of BV in a CPIP model remains unknown. The application of a tight-fitting O-ring around the left ankle for a period of 3 h generated CPIP in C57/Bl6 male adult mice. BV (1 mg/kg ; 1, 2, and 3 times) was administered into the SC layer of the hind paw, and the antiallodynic effects were investigated using the von Frey test and by measuring the expression of neurokinin type 1 (NK-1) receptors in dorsal root ganglia (DRG). The administration of BV dose-dependently reduced the pain withdrawal threshold to mechanical stimuli compared with the pre-administration value and with that of the control group. After the development of the CPIP model, the expression of NK-1 receptors in DRG increased and then decreased following the administration of BV. SC administration of BV results in the attenuation of allodynia in a mouse model of CPIP. The antiallodynic effect was objectively proven through a reduction in the increased expression of NK-1 receptors in DRG.

  13. Floating nuclear heat. And power station 'Pevec' with KLT-40S type reactor plant for remote regions of Russia

    International Nuclear Information System (INIS)

    Veshnyakov, K.B.; Kiryushin, A.I.; Panov, Yu.K.; Polunichev, V.I.

    2000-01-01

    Floating small nuclear power plants power for local energy systems of littoral regions of Russia, located far from central energy system, open a new line in nuclear power development. Designing a floating power unit of a lead nuclear heat and power generating station for port Pevec at the Chuckchee national district is currently nearing completion. Most labor-intensive components are being manufactured. The co-generation NPP Pevec is to be created on the basis of a floating power unit with KLT-40S type reactor plant. KLT-40S reactor plant is based on similar propulsion plants, verified at operation of Russia's nuclear-powered civil ships, evolutionary improved by elimination of 'weak points' revealed during its prototypes operation or on the basis of safety analysis. KLT-40S reactor plant uses the most wide-spread and developed in the world practice PWR-type reactor. KLT-40S meets contemporary national and international requirements imposed to future reactor plants. The NHPS description, its main technical-economic data, environmental safety indices, basic characteristics of KLT-40S reactor plant are presented. Prospects of small NPPs utilization outside Russia, particularly as an energy source for sea water desalination, are considered. (author)

  14. Use of circulation types classifications to evaluate AR4 climate models over the Euro-Atlantic region

    Energy Technology Data Exchange (ETDEWEB)

    Pastor, M.A.; Casado, M.J. [Agencia Estatal de Meteorologia (AEMET), Madrid (Spain)

    2012-10-15

    This paper presents an evaluation of the multi-model simulations for the 4th Assessment Report of the Intergovernmental Panel on Climate Change (IPCC) in terms of their ability to simulate the ERA40 circulation types over the Euro-Atlantic region in winter season. Two classification schemes, k-means and SANDRA, have been considered to test the sensitivity of the evaluation results to the classification procedure. The assessment allows establishing different rankings attending spatial and temporal features of the circulation types. Regarding temporal characteristics, in general, all AR4 models tend to underestimate the frequency of occurrence. The best model simulating spatial characteristics is the UKMO-HadGEM1 whereas CCSM3, UKMO-HadGEM1 and CGCM3.1(T63) are the best simulating the temporal features, for both classification schemes. This result agrees with the AR4 models ranking obtained when having analysed the ability of the same AR4 models to simulate Euro-Atlantic variability modes. This study has proved the utility of applying such a synoptic climatology approach as a diagnostic tool for models' assessment. The ability of the models to properly reproduce the position of ridges and troughs and the frequency of synoptic patterns, will therefore improve our confidence in the response of models to future climate changes. (orig.)

  15. Anti tumor necrosis factor - alpha adalimumab for complex regional pain syndrome type 1 (CRPS-I): a case series.

    Science.gov (United States)

    Eisenberg, Elon; Sandler, Ifat; Treister, Roi; Suzan, Erica; Haddad, May

    2013-11-01

    Evidence suggests tumor necrosis factor-alpha (TNF-α) mediates, at least in part, symptoms and signs in complex regional pain syndrome (CRPS). Here, we present a case series of patients with CRPS type 1, in whom the response to the anti-TNF-α adalimumab was assessed. Ten patients with CRPS type 1 were recruited. Assessments were performed before treatment, at 1 week, and 1, 3, and 6 months following 3 biweekly subcutaneous injections (40 mg/0.8 mL) adalimumab (Humira(®) ) and included the followings: Pain intensity using a 0-10 cm visual analog scale; the Short Form of the McGill Pain Questionnaire; the Beck Depression Inventory; the SF-36 questionnaire and mechanical and thermal thresholds (Von frey hair and Thermal Sensory Analyzer, respectively). In addition to the description of individual patient responses, both intention to treat (ITT) and per-protocol (PP) analyses were performed for the entire group. Three subgroups of patients were identified (3 patients in each): "nonresponders", "partial responders", and "robust responders" in whom improvement in almost all parameters was noted. Both the ITT and PP analyses demonstrated only a trend toward improvement in mechanical pain thresholds following treatment (ITT χ² = 13.83, P = 0.008; PP χ² = 10.29, P = 0.036). These results suggest adalimumab, and possibly other anti-TNF-α, can be potentially useful in some (although not in all) patients with CRPS type 1. These preliminary results along with the growing body of evidence which points to the involvement of TNF-α in the pathogenesis of CRPS justify further studies in this area. © 2013 World Institute of Pain.

  16. Extension of a Computer Assisted Decision Support (CADS) Study to Improve Outcomes in Patients with Type 2 DM Treated by Primary Care Providers. Addendum

    Science.gov (United States)

    2015-04-01

    physicians’ assistants, who are not necessarily equipped with the latest information and tools to provide optimum care nor have the time required to...web-assisted DM management, most have used the web for patient education, performance monitoring, risk stratification , and case management by nurses...research staff to maintain CDMP and CADS and to assist with patient and provider problems that could not be solved by the research staff. Reportable

  17. Effects of trap-assisted tunneling on gate-induced drain leakage in silicon-germanium channel p-type FET for scaled supply voltages

    Science.gov (United States)

    Tiwari, Vishal A.; Divakaruni, Rama; Hook, Terence B.; Nair, Deleep R.

    2016-04-01

    Silicon-germanium is considered as an alternative channel material to silicon p-type FET (pFET) for the development of energy efficient high performance transistors for 28 nm and beyond in a high-k metal gate technology because of its lower threshold voltage and higher mobility. However, gate-induced drain leakage (GIDL) is a concern for high threshold voltage device design because of tunneling at reduced bandgap. In this work, the trap-assisted tunneling and band-to-band tunneling (BTBT) effects on GIDL is analyzed and modeled for SiGe pFETs. Experimental results and Monte Carlo simulation results reveal that the pre-halo germanium pre-amorphization implant used to contain the short channel effects contribute to GIDL at the drain sidewall in addition to GIDL due to BTBT in SiGe devices. The results are validated by comparing the experimental observations with the numerical simulation and a set of calibrated models are used to describe the GIDL mechanisms for various drain and gate bias.

  18. Diabetes Medication Assistance Service: the pharmacist's role in supporting patient self-management of type 2 diabetes (T2DM) in Australia.

    Science.gov (United States)

    Mitchell, Bernadette; Armour, Carol; Lee, Mary; Song, Yun Ju; Stewart, Kay; Peterson, Greg; Hughes, Jeff; Smith, Lorraine; Krass, Ines

    2011-06-01

    To evaluate the capacity and effectiveness of trained community pharmacists in delivering the Diabetes Medication Assistance Service (DMAS) via (1) number and types of self-management support interventions (SMSIs); (2) number of goals set and attained by patients and (3) patient outcomes (glycaemic control, medication adherence and satisfaction). Pharmacists (n=109) from 90 community pharmacies in Australia were trained and credentialed to deliver the DMAS. The training focused on developing pharmacists' knowledge and skills in supporting patients' diabetes self-management. A total of 387 patients completed the trial. The mean number of SMSIs per patient was 35 (SD ±31) and the majority (87%) had at least one documented goal that was fully or partially attained. There were significant health benefits for patients including improved glycaemic control and a reduced risk of non-adherence to medications. Over 90% of DMAS patients reported improvements in their knowledge about diabetes self-management. The DMAS provides self management support in the community pharmacy for people with T2DM which may result in improved clinical outcomes. Given appropriate training in diabetes care and behavior change strategies, community pharmacists can offer programs which provide self-management support to their patients with T2DM and improve their health outcomes. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  19. Mutations of the interferon sensitivity-determining region (ISDR) correlate with the complexity of hypervariable region (HVR)-1 in the Japanese variant of hepatitis C virus (HCV) type 1b.

    Science.gov (United States)

    Nakano, Isao; Fukuda, Yoshihide; Katano, Yoshiaki; Toyoda, Hidenori; Hayashi, Kazuhiko; Kumada, Takashi; Nakano, Satoshi

    2004-09-01

    Hepatitis C virus (HCV) genotype 1b comprises mainly two subtypes in Japan, each named for its geographic prevalence (Japan-specific, J type; worldwide, W type). Because the newly identified subtypes have not been fully characterized, the present study directed this issue from virological viewpoints such as hypervariable region (HVR)-1 as well as interferon (IFN) sensitivity-determining region (ISDR). Fifty chronic hepatitis patients with HCV 1b (31 men and 19 women; mean age 50.5 years) were enrolled, and J/W type was determined according to envelope 1 (E1) sequence as described previously (23 J type and 27 W type). Correlations between age, number of HVR-1 clones, HVR-1 diversity, and ISDR mutations were analyzed in J and W type patients independently. In addition, the sequences of the three HCV regions obtained for the determination of the above genetic factors were studied phylogenetically. The number of HVR-1 clones was significantly higher for J type in comparison with W type (P = 0.044). In the J type-infected patients, the ISDR mutation number was correlated inversely with HVR-1 clone number (P = 0.0001, r = -0.734) and HVR-1 diversity (P = 0.0001, r = -0.722). However, this correlation was not observed in the W type patients. W type patients showed a significant correlation between age and HVR-1 clone number (P = 0.015, r = 0.462). Phylogenetic study revealed that the nonstructural (NS) 5A sequence, which is obtained for ISDR type determination, can distinguish between J and W types. The inverse correlation in J type patients between ISDR mutations and HVR-1 complexity may explain the usefulness of the ISDR for prediction of IFN response only in Japanese patients. This suggests that the ISDR is not directly related to IFN responsiveness, but the degree of HVR-1 complexity may be more important.

  20. Influences of Contrasting Types of Training on Practitioners' and Parents' Use of Assistive Technology and Adaptations with Infants, Toddlers and Preschoolers with Disabilities. Practical Evaluation Reports, Volume 3, Number 1

    Science.gov (United States)

    Dunst, Carl J.; Trivette, Carol M.; Meter, Diana; Hamby, Deborah W.

    2011-01-01

    The effectiveness of different types of practices for promoting practitioner and parent adoption of different kinds of assistive technology and adaptations with young children birth to 105 months of age was the focus of a meta-analysis. Six operationally defined adult learning method characteristics and between 2 and 5 practices for each…

  1. Geographic assistance of decontamination strategy elaboration

    International Nuclear Information System (INIS)

    Davydchuk, V.; Arapis, G.

    1996-01-01

    Those who elaborates the strategy of decontamination of vast territories is to take into consideration the heterogeneity of such elements of landscape as relief, lithology, humidity and types of soils and, vegetation, both on local and regional level. Geographic assistance includes evaluation of efficacy of decontamination technologies in different natural conditions, identification of areas of their effective application and definition of ecological damage, estimation of balances of the radionuclides in the landscapes to create background of the decontamination strategy

  2. Vibrational Markovian modelling of footprints after the interaction of antibiotics with the packaging region of HIV type 1.

    Science.gov (United States)

    Díaz, Humberto González; de Armas, Ronal Ramos; Molina, Reinaldo

    2003-11-01

    The design of novel anti-HIV compounds has now become a crucial area for scientists working in numerous interrelated fields of science such as molecular biology, medicinal chemistry, mathematical biology, molecular modelling and bioinformatics. In this context, the development of simple but physically meaningful mathematical models to represent the interaction between anti-HIV drugs and their biological targets is of major interest. One such area currently under investigation involves the targets in the HIV-RNA-packaging region. In the work described here, we applied Markov chain theory in an attempt to describe the interaction between the antibiotic paromomycin and the packaging region of the RNA in Type-1 HIV. In this model, a nucleic acid squeezed graph is used. The vertices of the graph represent the nucleotides while the edges are the phosphodiester bonds. A stochastic (Markovian) matrix was subsequently defined on this graph, an operation that codifies the probabilities of interaction between specific nucleotides of HIV-RNA and the antibiotic. The strength of these local interactions can be calculated through an inelastic vibrational model. The successive power of this matrix codifies the probabilities with which the vibrations after drug-RNA interactions vanish along the polynucleotide main chain. The sums of self-return probabilities in the k-vicinity of each nucleotide represent physically meaningful descriptors. A linear discriminant function was developed and gave rise to excellent discrimination in 80.8% of interacting and footprinted nucleotides. The Jackknife method was employed to assess the stability and predictability of the model. On the other hand, a linear regression model predicted the local binding affinity constants between a specific nucleotide and the antibiotic (R(2)=0.91, Q(2)=0.86). These kinds of models could play an important role either in the discovery of new anti-HIV compounds or the study of their mode of action.

  3. A STATISTICAL STUDY OF FLARE PRODUCTIVITY ASSOCIATED WITH SUNSPOT PROPERTIES IN DIFFERENT MAGNETIC TYPES OF ACTIVE REGIONS

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Ya-Hui [Institute of Space Science, National Central University, Jhongli 32001, Taiwan (China); Hsieh, Min-Shiu [Geophysical Institute, University of Alaska Fairbanks, AK 99775-7320 (United States); Yu, Hsiu-Shan [Center for Astrophysics and Space Sciences, University of California San Diego, CA 92093 (United States); Chen, P. F., E-mail: yhyang@jupiter.ss.ncu.edu.tw, E-mail: mhsieh2@alaska.edu, E-mail: hsyu@ucsd.edu, E-mail: chenpf@nju.edu.cn [School of Astronomy and Space Science, Nanjing University, Nanjing 210023 (China)

    2017-01-10

    It is often believed that intense flares preferentially originate from the large-size active regions (ARs) with strong magnetic fields and complex magnetic configurations. This work investigates the dependence of flare activity on the AR properties and clarifies the influence of AR magnetic parameters on the flare productivity, based on two data sets of daily sunspot and flare information as well as the GOES soft X-ray measurements and HMI vector magnetograms. By considering the evolution of magnetic complexity, we find that flare behaviors are quite different in the short- and long-lived complex ARs and the ARs with more complex magnetic configurations are likely to host more impulsive and intense flares. Furthermore, we investigate several magnetic quantities and perform the two-sample Kolmogorov–Smirnov test to examine the similarity/difference between two populations in different types of ARs. Our results demonstrate that the total source field strength on the photosphere has a good correlation with the flare activity in complex ARs. It is noted that intense flares tend to occur at the regions of strong source field in combination with an intermediate field-weighted shear angle. This result implies that the magnetic free energy provided by a complex AR could be high enough to trigger a flare eruption even with a moderate magnetic shear on the photosphere. We thus suggest that the magnetic free energy represented by the source field rather than the photospheric magnetic complexity is a better quantity to characterize the flare productivity of an AR, especially for the occurrence of intense flares.

  4. Prevalence and Risk Factors of Diabetic Nephropathy in Omani Type 2 Diabetics in Al-Dakhiliyah Region

    Directory of Open Access Journals (Sweden)

    Abdulhakeem Hamood Alrawahi

    2012-05-01

    Full Text Available Objective: To assess the prevalence and risk factors of diabetic nephropathy among Omani type 2 diabetics in Al-Dakhiliyah region of the Sultanate of Oman.Methods: A cross-sectional and a case control study designs were used to assess the prevalence and risk factors respectively. For the prevalence study a sample of 699 diabetic subjects were selected randomly from two polyclinics in Al-Dakhiliyah region; Sumail and Nizwa polyclinics. For the case control study, a sample consisting of 215 cases and 358 controls were randomly selected from those who were included in the cross-sectional study. A well designed questionnaire has been used to collect data regarding the disease and risk factors. Data was analyzed using SPSS19 statistical program.Results: Total prevalence of diabetic nephropathy was calculated as 42.5% (95% C.I: 38.83% - 46.15%. The difference in the prevalence in the two polyclinic catchment area was not significant. The prevalence was significantly higher among males (51.6% compared to females (36.5%. Crude analysis of the risk factors showed significant association between diabetic nephropathy and the following factors; male gender, decreased literacy, long duration of diabetes mellitus, hypertension, retinopathy, neuropathy, family history of diabetic nephropathy, poor glycemic control (high HbA1c, and hypertriglyceridemia. Multivariate analysis showed the following factors to be independent risk factors; male gender, decreased literacy, long duration of diabetes, family history of diabetic nephropathy and poor glycaemic control (high HbA1c.Conclusion: The prevalence of diabetic nephropathy in this study was 42.5% and the significant risk factors associated with it included male gender, decreased literacy, long duration of diabetes, family history of diabetic nephropathy and poor glycemic control (high HbA1c.

  5. Relation between the treated region of the patient with ca. of the uterine cervix and her body-type in whole pelvis irradiation with conformation technique

    International Nuclear Information System (INIS)

    Morita, Kozo; Kakehi, Masae

    1975-01-01

    In whole pelvis irradiation using the conformation technique for the patient with carcinoma of the uterine cervix, standardization of the shape of the treated region was tried on the basis of measuring the pelvis in X-ray films. This was done on the X-rays of 200 patients with carcinoma of the uterine cervix. The body-type of the patient the most remarkably influenced the shape of the treated region. Ten clinical types of cam-group (treated region) were determined, in order to perform conformation radiotherapy for carcinoma of the uterine cervix. Although the shape of the treated region could also be changed by the invasion of the lesion, the position of the portio and the general condition of the patients, these 10 standard types of cam-group can be applied practically to almost all of the patients. (Evans, J.)

  6. Minimally invasive scoliosis surgery assisted by O-arm navigation for Lenke Type 5C adolescent idiopathic scoliosis: a comparison with standard open approach spinal instrumentation.

    Science.gov (United States)

    Zhu, Weiguo; Sun, Weixiang; Xu, Leilei; Sun, Xu; Liu, Zhen; Qiu, Yong; Zhu, Zezhang

    2017-04-01

    OBJECTIVE Recently, minimally invasive scoliosis surgery (MISS) was introduced for the correction of adult scoliosis. Multiple benefits including a good deformity correction rate and fewer complications have been demonstrated. However, few studies have reported on the use of MISS for the management of adolescent idiopathic scoliosis (AIS). The purpose of this study was to investigate the outcome of posterior MISS assisted by O-arm navigation for the correction of Lenke Type 5C AIS. METHODS The authors searched a database for all patients with AIS who had been treated with either MISS or PSF between November 2012 and January 2014. Levels of fusion, density of implants, operation time, and estimated blood loss (EBL) were recorded. Coronal and sagittal parameters were evaluated before surgery, immediately after surgery, and at the last follow-up. The accuracy of pedicle screw placement was assessed according to postoperative axial CT images in both groups. The 22-item Scoliosis Research Society questionnaire (SRS-22) results and complications were collected during follow-up. RESULTS The authors retrospectively reviewed the records of 45 patients with Lenke Type 5C AIS, 15 who underwent posterior MISS under O-arm navigation and 30 who underwent posterior spinal fusion (PSF). The 2 treatment groups were matched in terms of baseline characteristics. Comparison of radiographic parameters revealed no obvious difference between the 2 groups immediately after surgery or at the final follow-up; however, the MISS patients had significantly less EBL (p self-image using the SRS-22 showed significantly higher scores in the MISS group (p = 0.013 and 0.046, respectively) than in the PSF group. Postoperative CT showed high accuracy in pedicle placement in both groups. No deep wound infection, pseudarthrosis, additional surgery, implant failure, or neurological complications were recorded in either group. CONCLUSIONS Minimally invasive scoliosis surgery is an effective and safe

  7. Mutual emergency assistance for radiation accidents

    International Nuclear Information System (INIS)

    1980-11-01

    In 1963 the International Atomic Energy Agency (IAEA) issued a document, WP.35, dated 23 November 1963, based on information provided by a number of its Member States on the type of radiological assistance that they might be able to make available in the event of a radiation emergency in another country at the request of that country. The document was subsequently revised in 1968 and 1971 with the participation of the World Health Organization (WHO), the Food and Agriculture Organization of the United Nations (FAO) and the International Labour Organisation (ILO). In 1979, an expanded questionnaire to ascertain what could be required by the State in the event of a major radiation accident, was sent jointly by these organizations with the participation of the Office of the United Nations Disaster Relief Co-ordinator (UNDRO), to all their Member States. The text of the expanded questionnaire is reproduced. The present document lists all the information, received up to mid 1980, that contains offers of assistance made by a State. It also lists information on the assistance that might be required by the State. In general, the replies have been reproduced in the form in which they were received, although a few changes in presentation have been introduced in the interest of brevity and clarity. Some countries have pointed out that their replies are necessarily of a general character and that the full extent of the assistance they would be capable of providing could be determined only after a specific request had been received. The information given in this document should therefore be regarded only as a guide to the type of radiological assistance that might be available and/or needed. Other available international assistance includes that provided by the Agency through the IAEA Radiation (Emergency) Assistance Procedures, by WHO through its system of Collaborating Centres on human radiation pathology, and by various States via regional or inter-countries' agreements on

  8. Multiplexed Microsphere Suspension-Array Assay for Urine Mitochondrial DNA Typing by C-Stretch Length in Hypervariable Regions.

    Science.gov (United States)

    Aoki, Kimiko; Tanaka, Hiroyuki; Kawahara, Takashi

    2018-07-01

    The standard method for personal identification and verification of urine samples in doping control is short tandem repeat (STR) analysis using nuclear DNA (nDNA). The DNA concentration of urine is very low and decreases under most conditions used for sample storage; therefore, the amount of DNA from cryopreserved urine samples may be insufficient for STR analysis. We aimed to establish a multiplexed assay for urine mitochondrial DNA typing containing only trace amounts of DNA, particularly for Japanese populations. A multiplexed suspension-array assay using oligo-tagged microspheres (Luminex MagPlex-TAG) was developed to measure C-stretch length in hypervariable region 1 (HV1) and 2 (HV2), five single nucleotide polymorphisms (SNPs), and one polymorphic indel. Based on these SNPs and the indel, the Japanese population can be classified into five major haplogroups (D4, B, M7a, A, D5). The assay was applied to DNA samples from urine cryopreserved for 1 - 1.5 years (n = 63) and fresh blood (n = 150). The assay with blood DNA enabled Japanese subjects to be categorized into 62 types, exhibiting a discriminatory power of 0.960. The detection limit for cryopreserved urine was 0.005 ng of nDNA. Profiling of blood and urine pairs revealed that 5 of 63 pairs showed different C-stretch patterns in HV1 or HV2. The assay described here yields valuable information in terms of the verification of urine sample sources employing only trace amounts of recovered DNA. However, blood cannot be used as a reference sample.

  9. The changes of regional cerebral blood flow: successful pain relief of intractable CRPS type II patients by motor cortex stimulation

    International Nuclear Information System (INIS)

    Jung, J. A.; Son, H. S.; Kim, S. H.; Jung, S. G

    2004-01-01

    Authors report the effectiveness of MCS in extraordinarily extended pain due to intractable CRPS type II and rCBF study result for mechanism of pain control by MCS. A 43-year-old male presented severe spontaneous burning pain in his left hand and forearm and allodynia over the left arm and left hemibody. Authors planned MCS as a neuromodulation therapy for this intractable peripheral neuropathic pain patient because further neurodestructive procedure did not work anymore and have a potential risk of further aggrevation of neuopathic pain. We performed baseline and stimulation brain perfusion SPECT using 20 mCi of Tc-99m ECD. The baseline CBD studies were done with stimulator 'off' state and stimulation studies were done after stimulator 'on' with satisfactory pain relief. For the stimulation study, the radioisotope was injected immediately after pain-relief and the images were taken about 50 minutes after injection of radioisotope. In resting rCBF in the patient was compared with normal control datas, we found significant increase in rCBF in the bilateral prefrontal cortex, right dorsolateral prefrontal cortex, right superior temporal gyrus, left temporooccipital area. When rCBF datas obtained after alleviation of pain with stimulator 'on' . there were significant increase in rCBF in bilateral prefrontal cortex and left temporoocipital area. After subtraction of ECD SPECT, we found significant increase in rCBF in the right premotor and supplementary motor cortex left sensorimotor cortex, right cingulated cortex, right posterior insular cortex, right anterior limb of internal capsule. left orbitofrontal cortex and right pyramidal tract in cerebral peduncle. Authors report exellent pain control by MCS in a case of severe CRPS type II with hemibody involvement and regional cerebral blood flow changes according to successful pain control

  10. The changes of regional cerebral blood flow: successful pain relief of intractable CRPS type II patients by motor cortex stimulation

    Energy Technology Data Exchange (ETDEWEB)

    Jung, J. A.; Son, H. S.; Kim, S. H.; Jung, S. G [The Catholic University of Korea, Seoul (Korea, Republic of)

    2004-07-01

    Authors report the effectiveness of MCS in extraordinarily extended pain due to intractable CRPS type II and rCBF study result for mechanism of pain control by MCS. A 43-year-old male presented severe spontaneous burning pain in his left hand and forearm and allodynia over the left arm and left hemibody. Authors planned MCS as a neuromodulation therapy for this intractable peripheral neuropathic pain patient because further neurodestructive procedure did not work anymore and have a potential risk of further aggrevation of neuopathic pain. We performed baseline and stimulation brain perfusion SPECT using 20 mCi of Tc-99m ECD. The baseline CBD studies were done with stimulator 'off' state and stimulation studies were done after stimulator 'on' with satisfactory pain relief. For the stimulation study, the radioisotope was injected immediately after pain-relief and the images were taken about 50 minutes after injection of radioisotope. In resting rCBF in the patient was compared with normal control datas, we found significant increase in rCBF in the bilateral prefrontal cortex, right dorsolateral prefrontal cortex, right superior temporal gyrus, left temporooccipital area. When rCBF datas obtained after alleviation of pain with stimulator 'on' . there were significant increase in rCBF in bilateral prefrontal cortex and left temporoocipital area. After subtraction of ECD SPECT, we found significant increase in rCBF in the right premotor and supplementary motor cortex left sensorimotor cortex, right cingulated cortex, right posterior insular cortex, right anterior limb of internal capsule. left orbitofrontal cortex and right pyramidal tract in cerebral peduncle. Authors report exellent pain control by MCS in a case of severe CRPS type II with hemibody involvement and regional cerebral blood flow changes according to successful pain control.

  11. Serological and molecular typing of HIV type 1 infection in the Tiriyo tribe, a native Indian community of the Amazon region of Brazil.

    Science.gov (United States)

    Machado, Luiz F A; Vallinoto, Antonio C R; Souza, Maria I M; Azevedo, Vania N; Ishak, Marluisa O G; Ishak, Ricardo

    2006-12-01

    The seroprevalence and the occurrence of an HIV-1 subtype was assessed in blood samples of the Tiriyo tribe. Antibody was found in 0.6% and the molecular analysis of the pro region detected the emergence of a subtype B for the first time in a native Indian tribe of the Amazon region of Brazil.

  12. 99mTc-HMPAO SPECT in dementia of the Alzheimer type. Hypoperfusion in the medial temporal region

    International Nuclear Information System (INIS)

    Nakamura, Yu; Kawakatsu, Shinobu; Shinohara, Masao; Nadaoka, Toshihide; Totsuka, Shiro; Komatani, Akio

    1995-01-01

    This study examined regional cerebral blood flow (rCBF) by single photon emission computed tomography (SPECT) using technetium 99m-hexamethyl-propyleneamineoxime and correlated the results with neuropsychological findings in 30 patients with dementia of the Alzheimer type (AT dementia). Ten healthy persons served as controls. The group of mild AT dementia exhibited a significant decrease in rCBF in the lower part of the right lateral frontal lobe and in the right parietal lobe. In the group of moderate AT dementia, the significant decrease in rCBF was noted in the lower part of the bilateral frontal lobes, the parietal part of the temporal lobe, the parietal lobe, and the medial temporal lobe. Factor analysis for neuropsychological test revealed three factors involved in rCBF. There was a significantly positive correlation between the factor responsible for memory and recall and rCBF in the left frontal lobe, the anterior part of the lateral temporal lobe, and the medial temporal lobe. These findings suggested that disturbance of the memory circuit may exist in the medial temporal lobe and others as pathophysiology of AT dementia. (N.K.)

  13. Comparison between New-Onset and Old-Diagnosed Type 2 Diabetes with Ketosis in Rural Regions of China

    Science.gov (United States)

    Du, Shichun; Yang, Xia; Shi, Degang; Su, Qing

    2016-01-01

    Objectives. Type 2 diabetes (T2D) with ketosis was common because of late diagnosis and lacking adequate treatment in rural regions of China. This study aimed to provide the data of T2D with ketosis among inpatients in a south-west border city of China. Methods. Data of 371 patients of T2D with ketosis who were hospitalized between January 2011 and July 2015 in Baoshan People's Hospital, Yunnan, China, were analyzed. New-onset and old-diagnosed T2D patients presenting with ketosis were compared according to clinical characteristics, laboratory results, and chronic diabetic complications. Results. Overall, the blood glucose control was poor in our study subjects. Male predominated in both groups (male prevalence was 68% in new-onset and 64% in old-diagnosed groups). Overweight and obesity accounted for 50% in new-onset and 46% in old-diagnosed cases. Inducements of ketosis were 13.8% in new-onset and 38.7% in old-diagnosed patients. Infections were the first inducements in both groups. The prevalence of chronic complications of diabetes was common in both groups. Conclusions. More medical supports were needed for the early detection and adequate treatment of diabetes in rural areas of China. PMID:26966435

  14. Mapping Plant Functional Types over Broad Mountainous Regions: A Hierarchical Soft Time-Space Classification Applied to the Tibetan Plateau

    Directory of Open Access Journals (Sweden)

    Danlu Cai

    2014-04-01

    Full Text Available Research on global climate change requires plant functional type (PFT products. Although several PFT mapping procedures for remote sensing imagery are being used, none of them appears to be specifically designed to map and evaluate PFTs over broad mountainous areas which are highly relevant regions to identify and analyze the response of natural ecosystems. We present a methodology for generating soft classifications of PFTs from remotely sensed time series that are based on a hierarchical strategy by integrating time varying integrated NDVI and phenological information with topography: (i Temporal variability: a Fourier transform of a vegetation index (MODIS NDVI, 2006 to 2010. (ii Spatial partitioning: a primary image segmentation based on a small number of thresholds applied to the Fourier amplitude. (iii Classification by a supervised soft classification step is based on a normalized distance metric constructed from a subset of Fourier coefficients and complimentary altitude data from a digital elevation model. Applicability and effectiveness is tested for the eastern Tibetan Plateau. A classification nomenclature is determined from temporally stable pixels in the MCD12Q1 time series. Overall accuracy statistics of the resulting classification reveal a gain of about 7% from 64.4% compared to 57.7% by the MODIS PFT products.

  15. ON THE AVERAGE DENSITY PROFILE OF DARK-MATTER HALOS IN THE INNER REGIONS OF MASSIVE EARLY-TYPE GALAXIES

    International Nuclear Information System (INIS)

    Grillo, C.

    2012-01-01

    We study a sample of 39 massive early-type lens galaxies at redshift z ∼< 0.3 to determine the slope of the average dark-matter density profile in the innermost regions. We keep the strong-lensing and stellar population synthesis modeling as simple as possible to measure the galaxy total and luminous masses. By rescaling the values of the Einstein radius and dark-matter projected mass with the values of the luminous effective radius and mass, we combine all the data of the galaxies in the sample. We find that between 0.3 and 0.9 times the value of the effective radius the average logarithmic slope of the dark-matter projected density profile is –1.0 ± 0.2 (i.e., approximately isothermal) or –0.7 ± 0.5 (i.e., shallower than isothermal), if, respectively, a constant Chabrier or heavier, Salpeter-like stellar initial mass function is adopted. These results provide positive evidence of the influence of the baryonic component on the contraction of the galaxy dark-matter halos, compared to the predictions of dark-matter-only cosmological simulations, and open a new way to test models of structure formation and evolution within the standard ΛCDM cosmological scenario.

  16. Comparative in vivo analysis of recombinant type II feline coronaviruses with truncated and completed ORF3 region.

    Directory of Open Access Journals (Sweden)

    Ádám Bálint

    Full Text Available Our previous in vitro comparative study on a feline coronavirus (FCoV pair, differing only in the intactness of their ORF3abc regions, showed that the truncated ORF3abc plays an important role in the efficient macrophage/monocyte tropism of type II feline infectious peritonitis virus (FIPV. In the present study, we describe a challenge experiment with the same recombinant FCoVs in order to gain data on the in vivo characteristics on these viruses. While parent virus FIPV DF-2 developed feline infectious peritonitis in all the infected cats, its recombinant virus PBFIPV-DF-2, differing only in seven nucleotides, proved to be surprisingly low virulent, although caused an acute febrile episode similarly to the original FIPV DF-2. PBFIPV-DF-2 infection induced significantly lower virus neutralization titers than its parent virus, and lacked the second phase of viremia and development of fatal course of the disease. The recombinant PBFIPV-DF-2-R3i with completed ORF3abc gained biological properties that differentiate between the feline enteric coronavirus (FECV and FIPV biotypes such as intensive replication in the gut, absence of viremia and weak or no serological response. Using reverse genetic approaches our study is the first experimental proof that ORF3abc is indeed responsible for the restriction of FECV replication to the intestine in vivo.

  17. Comparative In Vivo Analysis of Recombinant Type II Feline Coronaviruses with Truncated and Completed ORF3 Region

    Science.gov (United States)

    Bálint, Ádám; Farsang, Attila; Zádori, Zoltán; Belák, Sándor

    2014-01-01

    Our previous in vitro comparative study on a feline coronavirus (FCoV) pair, differing only in the intactness of their ORF3abc regions, showed that the truncated ORF3abc plays an important role in the efficient macrophage/monocyte tropism of type II feline infectious peritonitis virus (FIPV). In the present study, we describe a challenge experiment with the same recombinant FCoVs in order to gain data on the in vivo characteristics on these viruses. While parent virus FIPV DF-2 developed feline infectious peritonitis in all the infected cats, its recombinant virus PBFIPV-DF-2, differing only in seven nucleotides, proved to be surprisingly low virulent, although caused an acute febrile episode similarly to the original FIPV DF-2. PBFIPV-DF-2 infection induced significantly lower virus neutralization titers than its parent virus, and lacked the second phase of viremia and development of fatal course of the disease. The recombinant PBFIPV-DF-2-R3i with completed ORF3abc gained biological properties that differentiate between the feline enteric coronavirus (FECV) and FIPV biotypes such as intensive replication in the gut, absence of viremia and weak or no serological response. Using reverse genetic approaches our study is the first experimental proof that ORF3abc is indeed responsible for the restriction of FECV replication to the intestine in vivo. PMID:24586385

  18. Regional cerebral metabolic alterations in dementia of the Alzheimer type: positron emission tomography with [18F]fluorodeoxyglucose

    International Nuclear Information System (INIS)

    Friedland, R.P.; Budinger, T.F.; Ganz, E.; Yano, Y.; Mathis, C.A.; Koss, B.; Ober, B.A.; Huesman, R.H.; Derenzo, S.E.

    1983-01-01

    Alzheimer disease is the most common cause of dementia in adults. Despite recent advances in our understanding of its anatomy and chemistry, we remain largely ignorant of its pathogenesis, physiology, diagnosis, and treatment. Dynamic positron emission tomography using [ 18 F]fluorodeoxyglucose (FDG) was performed on the Donner 280-crystal ring in 10 subjects with dementia of the Alzheimer type and six healthy age-matched controls. Ratios comparing mean counts per resolution element in frontal, temporoparietal, and entire cortex regions in brain sections 10 mm thick obtained 40-70 min following FDG injection showed relatively less FDG uptake in the temporoparietal cortex bilaterally in all the Alzheimer subjects (p less than 0.01). Left-right alterations were less prominent than the anteroposterior changes. This diminished uptake was due to lowered rates of FDG use and suggests that the metabolic effects of Alzheimer disease are most concentrated in the temporoparietal cortex. Positron emission tomography is a most powerful tool for the noninvasive in vivo assessment of cerebral pathophysiology in dementia

  19. Assistive Technology

    Science.gov (United States)

    ... Page Resize Text Printer Friendly Online Chat Assistive Technology Assistive technology (AT) is any service or tool that helps ... be difficult or impossible. For older adults, such technology may be a walker to improve mobility or ...

  20. Assisted Living

    Science.gov (United States)

    ... it, too. Back to top What is the Cost for Assisted Living? Although assisted living costs less than nursing home ... Primarily, older persons or their families pay the cost of assisted living. Some health and long-term care insurance policies ...

  1. Update on Pneumocystis carinii f. sp. hominis Typing Based on Nucleotide Sequence Variations in Internal Transcribed Spacer Regions of rRNA Genes

    Science.gov (United States)

    Lee, Chao-Hung; Helweg-Larsen, Jannik; Tang, Xing; Jin, Shaoling; Li, Baozheng; Bartlett, Marilyn S.; Lu, Jang-Jih; Lundgren, Bettina; Lundgren, Jens D.; Olsson, Mats; Lucas, Sebastian B.; Roux, Patricia; Cargnel, Antonietta; Atzori, Chiara; Matos, Olga; Smith, James W.

    1998-01-01

    Pneumocystis carinii f. sp. hominis isolates from 207 clinical specimens from nine countries were typed based on nucleotide sequence variations in the internal transcribed spacer regions I and II (ITS1 and ITS2, respectively) of rRNA genes. The number of ITS1 nucleotides has been revised from the previously reported 157 bp to 161 bp. Likewise, the number of ITS2 nucleotides has been changed from 177 to 192 bp. The number of ITS1 sequence types has increased from 2 to 15, and that of ITS2 has increased from 3 to 14. The 15 ITS1 sequence types are designated types A through O, and the 14 ITS2 types are named types a through n. A total of 59 types of P. carinii f. sp. hominis were found in this study. PMID:9508304

  2. Identification of an ICP27-responsive element in the coding region of a herpes simplex virus type 1 late gene.

    Science.gov (United States)

    Sedlackova, Lenka; Perkins, Keith D; Meyer, Julia; Strain, Anna K; Goldman, Oksana; Rice, Stephen A

    2010-03-01

    During productive herpes simplex virus type 1 (HSV-1) infection, a subset of viral delayed-early (DE) and late (L) genes require the immediate-early (IE) protein ICP27 for their expression. However, the cis-acting regulatory sequences in DE and L genes that mediate their specific induction by ICP27 are unknown. One viral L gene that is highly dependent on ICP27 is that encoding glycoprotein C (gC). We previously demonstrated that this gene is posttranscriptionally transactivated by ICP27 in a plasmid cotransfection assay. Based on our past results, we hypothesized that the gC gene possesses a cis-acting inhibitory sequence and that ICP27 overcomes the effects of this sequence to enable efficient gC expression. To test this model, we systematically deleted sequences from the body of the gC gene and tested the resulting constructs for expression. In so doing, we identified a 258-bp "silencing element" (SE) in the 5' portion of the gC coding region. When present, the SE inhibits gC mRNA accumulation from a transiently transfected gC gene, unless ICP27 is present. Moreover, the SE can be transferred to another HSV-1 gene, where it inhibits mRNA accumulation in the absence of ICP27 and confers high-level expression in the presence of ICP27. Thus, for the first time, an ICP27-responsive sequence has been identified in a physiologically relevant ICP27 target gene. To see if the SE functions during viral infection, we engineered HSV-1 recombinants that lack the SE, either in a wild-type (WT) or ICP27-null genetic background. In an ICP27-null background, deletion of the SE led to ICP27-independent expression of the gC gene, demonstrating that the SE functions during viral infection. Surprisingly, the ICP27-independent gC expression seen with the mutant occurred even in the absence of viral DNA synthesis, indicating that the SE helps to regulate the tight DNA replication-dependent expression of gC.

  3. Characteristics of three-grid type modulated Bayard-Alpert ionization gauge in ultra high vacuum region

    International Nuclear Information System (INIS)

    Kanaji, Toru; Urano, Toshio

    1981-01-01

    In Bayard-Alpert (B-A) ionization gauges widely used as total pressure-measuring gauges, the collector current is expressed as the sum of ion current Ii and soft X-ray photoelectron current Ix, if noise current is composed of only Ix. Ii and Ix are proportional to emission current Ie, respectively, and the pressure Px = α/S at which Ie is equal to Ix is called X-ray limit pressure, where α is X-ray current generating rate, and S is sensitivity coefficient. Therefore, it is necessary to make α smaller, and at the same time, to make S larger in order to reduce Px. But actually, the noise current is not composed of Ix only. Thereupon, the collector current other than true ion current in the lump is expressed as In, then the measuring limit pressure can be improved by epsilon n/kappa fold, where epsilon n and kappa are modulation coefficients of In and Ii, respectively. The authors have studied the three concentric cylindrical grid type modulated B-A gauge, and presently are working to try to make epsilon n smaller, putting the emphasis on holding the electric field around the collector constant. By the detailed consideration on the noise current of this gauge, it can be expected that the gauge holds linearity down to considerably low pressure region, but there are many problems to verify it. Thus this gauge is expected to be developed further as the gauges for ultra-high vacuum application. (Wakatsuki, Y.)

  4. Relationship Between HbA1c and Complex Regional Pain Syndrome in Stroke Patients With Type 2 Diabetes Mellitus

    Science.gov (United States)

    2016-01-01

    Objective To investigate the relationship between glycosylated hemoglobin A (HbA1c) and complex regional pain syndrome (CRPS) in stroke patients with type 2 diabetes mellitus (T2DM). Methods A retrospective chart review was performed of stroke patients from January 2012 to December 2013. We reviewed 331 patients and included 200 in the analysis. We divided them into CRPS and non-CRPS groups and compared them by age, gender, stroke lesion, cause of stroke, duration of T2DM, HbA1c (%), National Institutes of Health Stroke Scale score, affected shoulder flexor muscle strength, Fugl-Meyer Assessment score, motricity index, Functional Independence Measure, Korean version of Modified Barthel Index, blood glucose level on admission day, duration from stroke onset to HbA1c check, and duration from stroke onset to three-phase bone scan for CRPS diagnosis. Thereafter, we classified the patients into five groups by HbA1c level (group 1, 5.0%–5.9%; group 2, 6.0%–6.9%; group 3, 7.0%–7.9%; group 4, 8.0%–8.9%; and group 5, 9.0%–9.9%) and we investigated the difference in CRPS prevalence between the two groups. Results Of the 200 patients, 108 were in the CRPS group and 92 were in the non-CRPS group. There were significant differences in HbA1c (pCRPS prevalence (pCRPS prevalence and thus that uncontrolled blood glucose can affect CRPS occurrence in stroke patients with diabetes. PMID:27847707

  5. Diagnostic Performance of Three Phase Bone Scan for Complex Regional Pain Syndrome Type 1 with Optimally Modified Image Criteria

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Hyun Woo; Paeng, Jin Chul; Nahm, Francins Sahngun; Kim, Seog Gyun; Zehra, Tanzeel; Oh, So Won; Lee, Hyo Sang; Kang, Keon Wook; Chung, June Key; Lee, Myung Chul; Lee, Dong Soo [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2011-12-15

    Although the three phase bone scan (TBPS) is one of the widely used imaging studies for diagnosing complex regional pain syndrome type 1 (CRPS 1), there is some controversy regarding the TPBS image criteria for CRPS 1. In this study, we modified the image criteria using image pattern and quantitative analysis in the patients diagnosed using the most recent consensus clinical diagnostic criteria. The study included 140 patients with suspected CRPS 1 (CRPS 1, n=79; non CRPS, n=61; mean age 39{+-}15 years) who underwent TPBS. The clinical diagnostic criteria for CRPS 1 revised by the Budapest consensus group were used for confirmative diagnosis. Patients were classified according to flow/pool and delayed uptake (DU) image patterns, and the time interval between the initiating event and TPBS (TI{sup eventscan)}. Quantitative analysis for lesion to contralateral ratio (LCR) was performed. Modified TPBS image criteria were created and evaluated for optimal diagnostic performance. Both increased and decreased periarticular DU were significant image findings for CRPS 1 (CRPS 1 positive rate=73% in the increased DU group, 75% in the decreased DU group). The TI{sup eventscand}id not differ significantly between the different image pattern groups. Quantitative analysis revealed an LCR of 1.43 was the optimal cutoff value for CRPS 1 and diagnostic performance was significantly improved in the increased DU group (area under the curve=0.732). Given the modified image criteria, the sensitivity and specificity of TPBS for diagnosing CRPS 1 were 80% and 72%, respectively. Optimally modified TPBS image criteria for CRPS 1 were suggested using image pattern and quantitative analysis. With the criteria, TPBS is an effective imaging study for CRPS 1 even with the most recent consensus clinical diagnostic criteria.

  6. Diagnostic Performance of Three Phase Bone Scan for Complex Regional Pain Syndrome Type 1 with Optimally Modified Image Criteria

    International Nuclear Information System (INIS)

    Kwon, Hyun Woo; Paeng, Jin Chul; Nahm, Francins Sahngun; Kim, Seog Gyun; Zehra, Tanzeel; Oh, So Won; Lee, Hyo Sang; Kang, Keon Wook; Chung, June Key; Lee, Myung Chul; Lee, Dong Soo

    2011-01-01

    Although the three phase bone scan (TBPS) is one of the widely used imaging studies for diagnosing complex regional pain syndrome type 1 (CRPS 1), there is some controversy regarding the TPBS image criteria for CRPS 1. In this study, we modified the image criteria using image pattern and quantitative analysis in the patients diagnosed using the most recent consensus clinical diagnostic criteria. The study included 140 patients with suspected CRPS 1 (CRPS 1, n=79; non CRPS, n=61; mean age 39±15 years) who underwent TPBS. The clinical diagnostic criteria for CRPS 1 revised by the Budapest consensus group were used for confirmative diagnosis. Patients were classified according to flow/pool and delayed uptake (DU) image patterns, and the time interval between the initiating event and TPBS (TI eventscan) . Quantitative analysis for lesion to contralateral ratio (LCR) was performed. Modified TPBS image criteria were created and evaluated for optimal diagnostic performance. Both increased and decreased periarticular DU were significant image findings for CRPS 1 (CRPS 1 positive rate=73% in the increased DU group, 75% in the decreased DU group). The TI eventscand id not differ significantly between the different image pattern groups. Quantitative analysis revealed an LCR of 1.43 was the optimal cutoff value for CRPS 1 and diagnostic performance was significantly improved in the increased DU group (area under the curve=0.732). Given the modified image criteria, the sensitivity and specificity of TPBS for diagnosing CRPS 1 were 80% and 72%, respectively. Optimally modified TPBS image criteria for CRPS 1 were suggested using image pattern and quantitative analysis. With the criteria, TPBS is an effective imaging study for CRPS 1 even with the most recent consensus clinical diagnostic criteria.

  7. Intelligent Speed Assistance (ISA).

    NARCIS (Netherlands)

    2015-01-01

    Intelligent Speed Assistance (ISA) has been a promising type of advanced driver support system for some decades. From a technical point of view, large scale ISA implementation is possible in the short term. The different types of ISA are expected to have different effects on behaviour and traffic

  8. Regional prognosis criteria for the sandstone type uranium deposits in interlayer oxidation zone and their application in the east of Junggar basin, Xinjiang

    International Nuclear Information System (INIS)

    Han Deren; Bai Fengzhou; Lin Shuangxing

    1995-01-01

    Regional prognosis is of a very important role in the exploration work of the sandstone type uranium deposits of interlayer oxidation zone. This paper presents regional prognosis criteria on the basis of the authors' research in combination with the geological prediction in the east of Junggar Basin, Xinjiang (1:200000) which was jointly carried out with the Red Hill Geological Complex of the National Mineral Resources Commission of Uzbekistan Republic. It is advantageous to the exploration work of the sandstone type uranium deposits of interlayer oxidation zone in Meso-Cenozoic basins of China

  9. Development of an ideal plant type and male sterility system in sesame suitable for summer rice fallow in the coastal regions of Tamil Nadu

    International Nuclear Information System (INIS)

    Ganesan, J.

    2001-01-01

    In Tamil Nadu, sesame growing on available residual soil moisture after the rice harvest is expanding. In order to achieve higher and more reliable yields under these conditions, a more suitable plant type is needed: with shorter stature and growing period, moderate basal branching and higher productivity. Seeds of 6 varieties were treated with gamma rays, diethyl sulphate (DES) and ethyl methane sulphonate (EMS). The M 1 -M 4 generations were studied and several promising mutants were selected. Among them were also male sterile mutants; it is thought that such mutants will assist in producing hybrid varieties which will give the desired yield breakthrough. (author)

  10. Influence of dyslipidemia in control of arterial hypertension among type-2 diabetics in the western region of the Republic of Macedonia

    OpenAIRE

    Jani, Ylber; Kamberi, Amet; Ferati, Fatmir; Rexhepi, Atila; Pocesta, Bekim; Orovcanec, Nikola; Lala, Dali; Polisi, Gafur; Iseni, Mair; Mirto, Arben; Zeqiri, Agim

    2014-01-01

    Objective: To determine the influence of dyslipidemia in control of blood pressure in patients with type 2 Diabetes. To test the hypothesis that, blood pressure and lipid levels are not sufficiently controlled in patients with type 2 Diabetes, in the western region of the Republic of Macedonia. Background: Abnormalities of lipid and lipoprotein levels in the serum (dyslipidemia) are recognized as major modifiable cardiovascular disease risk factors and have been identified as independent risk...

  11. Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II.

    Science.gov (United States)

    Smart, Keith M; Wand, Benedict M; O'Connell, Neil E

    2016-02-24

    Complex regional pain syndrome (CRPS) is a painful and disabling condition that usually manifests in response to trauma or surgery. When it occurs, it is associated with significant pain and disability. It is thought to arise and persist as a consequence of a maladaptive pro-inflammatory response and disturbances in sympathetically-mediated vasomotor control, together with maladaptive peripheral and central neuronal plasticity. CRPS can be classified into two types: type I (CRPS I) in which a specific nerve lesion has not been identified, and type II (CRPS II) where there is an identifiable nerve lesion. Guidelines recommend the inclusion of a variety of physiotherapy interventions as part of the multimodal treatment of people with CRPS, although their effectiveness is not known. To determine the effectiveness of physiotherapy interventions for treating the pain and disability associated with CRPS types I and II. We searched the following databases from inception up to 12 February 2015: CENTRAL (the Cochrane Library), MEDLINE, EMBASE, CINAHL, PsycINFO, LILACS, PEDro, Web of Science, DARE and Health Technology Assessments, without language restrictions, for randomised controlled trials (RCTs) of physiotherapy interventions for treating pain and disability in people CRPS. We also searched additional online sources for unpublished trials and trials in progress. We included RCTs of physiotherapy interventions (including manual therapy, therapeutic exercise, electrotherapy, physiotherapist-administered education and cortically directed sensory-motor rehabilitation strategies) employed in either a stand-alone fashion or in combination, compared with placebo, no treatment, another intervention or usual care, or of varying physiotherapy interventions compared with each other in adults with CRPS I and II. Our primary outcomes of interest were patient-centred outcomes of pain intensity and functional disability. Two review authors independently evaluated those studies

  12. Analysis of changes in sagging type ST-T segment induced by exercise. Assessment of regional myocardial blood flow using quantitative 13NH3 positron emission tomography

    International Nuclear Information System (INIS)

    Watanabe, Takuya; Akutsu, Yasushi; Okazaki, Osamu

    1995-01-01

    Regional myocardial blood flow (RMBF) associated with exercise-induced ST depression was assessed using 13 NH 3 positron emission tomography (PET) to determine the significance of horizontal and sagging type ST segments. The subjects were 25 patients with angina pectoris, 25 patients with myocardial infarction, and 5 healthy male volunteers. Eleven regions of interests (ROI) were prepared to calculate RMBF. ST segments were unchanged in 27 patients (Group A) and were depressed in 23 patients (Group B). A 10% increase in RMBF was significantly observed in Group A (74.1%) than Group B (34.8%). In Group B, ST depression was divided into horizontal type (8 patients) and sagging type (15 patients). According to the type of ST depression, RMBF was increased by 10% or more in 50% (4/8) for horizontal type and in 26.7% (4/15) for sagging type. These findings suggested that unfavorable increase in RMBF in stenosiss-related coronary vessels may contribute to the development of ST depression induced by exercise. A constant increase in RMBF in all ROIs, including those with unfavorable RMBF increase, may be involved in the occurrence of horizontal type ST depression; sagging type ST depression may, however, occur by an increased difference in blood flow between unfavorable and favorable RMBF. (N.K.)

  13. A new scheme for strain typing of methicillin-resistant Staphylococcus aureus on the basis of matrix-assisted laser desorption ionization time-of-flight mass spectrometry by using machine learning approach.

    Science.gov (United States)

    Wang, Hsin-Yao; Lee, Tzong-Yi; Tseng, Yi-Ju; Liu, Tsui-Ping; Huang, Kai-Yao; Chang, Yung-Ta; Chen, Chun-Hsien; Lu, Jang-Jih

    2018-01-01

    Methicillin-resistant Staphylococcus aureus (MRSA), one of the most important clinical pathogens, conducts an increasing number of morbidity and mortality in the world. Rapid and accurate strain typing of bacteria would facilitate epidemiological investigation and infection control in near real time. Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry is a rapid and cost-effective tool for presumptive strain typing. To develop robust method for strain typing based on MALDI-TOF spectrum, machine learning (ML) is a promising algorithm for the construction of predictive model. In this study, a strategy of building templates of specific types was used to facilitate generating predictive models of methicillin-resistant Staphylococcus aureus (MRSA) strain typing through various ML methods. The strain types of the isolates were determined through multilocus sequence typing (MLST). The area under the receiver operating characteristic curve (AUC) and the predictive accuracy of the models were compared. ST5, ST59, and ST239 were the major MLST types, and ST45 was the minor type. For binary classification, the AUC values of various ML methods ranged from 0.76 to 0.99 for ST5, ST59, and ST239 types. In multiclass classification, the predictive accuracy of all generated models was more than 0.83. This study has demonstrated that ML methods can serve as a cost-effective and promising tool that provides preliminary strain typing information about major MRSA lineages on the basis of MALDI-TOF spectra.

  14. Rapid, sensitive, type specific PCR detection of the E7 region of human papillomavirus type 16 and 18 from paraffin embedded sections of cervical carcinoma

    DEFF Research Database (Denmark)

    Lesnikova, Iana; Lidang, Marianne; Hamilton-Dutoit, Stephen Jacques

    2010-01-01

    ABSTRACT: Human papillomavirus (HPV) infection, and in particularly infection with HPVs 16 and 18 is a central carcinogenic factor in the uterine cervix. We established and optimized a PCR assay for the detection and discrimination of HPV types 16 and 18 in archival formaldehyde fixed and paraffin...... embedded (FFPE) sections of cervical cancer. Tissue blocks from 35 cases of in situ or invasive cervical squamouscell carcinoma and surrogate FFPE sections containing the cell lines HeLa and SiHa were tested for HPV 16 and HPV18 and for the housekeeping gene beta-actin by conventional PCR using type...

  15. Rapid, sensitive, type specific PCR detection of the E7 region of human papillomavirus type 16 and 18 from paraffin embedded sections of cervical carcinoma

    DEFF Research Database (Denmark)

    Lesnikova, Iana; Lidang, Marianne; Hamilton-Dutoit, Steven

    2010-01-01

    ABSTRACT: Human papillomavirus (HPV) infection, and in particularly infection with HPVs 16 and 18, is a central carcinogenic factor in the uterine cervix. We established and optimized a PCR assay for the detection and discrimination of HPV types 16 and 18 in archival formaldehyde fixed and paraffin...... embedded (FFPE) sections of cervical cancer.Tissue blocks from 35 cases of in situ or invasive cervical squamous cell carcinoma and surrogate FFPE sections containing the cell lines HeLa and SiHa were tested for HPV 16 and HPV18 by conventional PCR using type specific primers, and for the housekeeping gene...

  16. Peopling of the North Circumpolar Region--insights from Y chromosome STR and SNP typing of Greenlanders.

    Directory of Open Access Journals (Sweden)

    Jill Katharina Olofsson

    Full Text Available The human population in Greenland is characterized by migration events of Paleo- and Neo-Eskimos, as well as admixture with Europeans. In this study, the Y-chromosomal variation in male Greenlanders was investigated in detail by typing 73 Y-chromosomal single nucleotide polymorphisms (Y-SNPs and 17 Y-chromosomal short tandem repeats (Y-STRs. Approximately 40% of the analyzed Greenlandic Y chromosomes were of European origin (I-M170, R1a-M513 and R1b-M343. Y chromosomes of European origin were mainly found in individuals from the west and south coasts of Greenland, which is in agreement with the historic records of the geographic placements of European settlements in Greenland. Two Inuit Y-chromosomal lineages, Q-M3 (xM19, M194, L663, SA01 and L766 and Q-NWT01 (xM265 were found in 23% and 31% of the male Greenlanders, respectively. The time to the most recent common ancestor (TMRCA of the Q-M3 lineage of the Greenlanders was estimated to be between 4,400 and 10,900 years ago (y. a. using two different methods. This is in agreement with the theory that the North Circumpolar Region was populated via a second expansion of humans in the North American continent. The TMRCA of the Q-NWT01 (xM265 lineage in Greenland was estimated to be between 7,000 and 14,300 y. a. using two different methods, which is older than the previously reported TMRCA of this lineage in other Inuit populations. Our results indicate that Inuit individuals carrying the Q-NWT01 (xM265 lineage may have their origin in the northeastern parts of North America and could be descendants of the Dorset culture. This in turn points to the possibility that the current Inuit population in Greenland is comprised of individuals of both Thule and Dorset descent.

  17. CURRENT TRENDS OF THE REGIONAL DEVELOPMENT POLICY IN THE EUROPEAN UNION. THE DEVELOPMENT OF COMPETITIVE ECONOMIC AGGLOMERATIONS OF CLUSTER TYPE

    Directory of Open Access Journals (Sweden)

    LAURA CISMAŞ

    2010-01-01

    Full Text Available The study of economic agents’ behaviour, whose nowadays tendency is togroup themselves in space as clusters, has an important place in the field of localizing industrialactivities. This is due to domestic scale economies, known as agglomerations economies.According to Edgar M. Hoover (Hoover, 1948, domestic scale economies are specific tocompanies; the economies of localizing - to a certain branch, whose companies form clusters incertain geographical arias, and the urbanization economies are specific to cities, where thereare clusters of companies from different branches. The specialty literature regarding localeconomic development, based on the idea of cluster starts from well-known economic theories,such as: agglomeration theory (Alfred Marshall, the theory of spatial localizing of industrialunits (Alfred Weber, the theory of interdependence of locations (Harold Hotelling, the diamondtheory (Michael Porter, the theory of entrepreneurship (Joseph Schumpeter, the theory ofgeographical concentration. Basically, the common point which links them are the conceptswhich occur in these theories, such as: industrial district, industrial agglomeration, spatialinterdependence, concepts which lie at the basis of the cluster idea. Clusters represent animportant instrument for promoting industrial development, innovation, competitiveness andeconomic growth. If, at the beginning, the effort to develop clusters belonged to private personsand companies, nowadays, the actors involved in their development are the governments andpublic institutions of national or regional level.The objective established within the Lisbon Strategy (2000, to make the EuropeanUnion “the most competitive and dynamic knowledge-based economy”, is tightly linked to thenew approaches of the European economic policy, to competitiveness. One of the policies isfocused on developing at the European Union level clusters in the high competitiveness fields. with an innovative character

  18. Influence of the transition region between p- and n-type polycrystalline silicon passivating contacts on the performance of interdigitated back contact silicon solar cells

    Science.gov (United States)

    Reichel, Christian; Müller, Ralph; Feldmann, Frank; Richter, Armin; Hermle, Martin; Glunz, Stefan W.

    2017-11-01

    Passivating contacts based on thin tunneling oxides (SiOx) and n- and p-type semi-crystalline or polycrystalline silicon (poly-Si) enable high passivation quality and low contact resistivity, but the integration of these p+/n emitter and n+/n back surface field junctions into interdigitated back contact silicon solar cells poses a challenge due to high recombination at the transition region from p-type to n-type poly-Si. Here, the transition region was created in different configurations—(a) p+ and n+ poly-Si regions are in direct contact with each other ("pn-junction"), using a local overcompensation (counterdoping) as a self-aligning process, (b) undoped (intrinsic) poly-Si remains between the p+ and n+ poly-Si regions ("pin-junction"), and (c) etched trenches separate the p+ and n+ poly-Si regions ("trench")—in order to investigate the recombination characteristics and the reverse breakdown behavior of these solar cells. Illumination- and injection-dependent quasi-steady state photoluminescence (suns-PL) and open-circuit voltage (suns-Voc) measurements revealed that non-ideal recombination in the space charge regions with high local ideality factors as well as recombination in shunted regions strongly limited the performance of solar cells without a trench. In contrast, solar cells with a trench allowed for open-circuit voltage (Voc) of 720 mV, fill factor of 79.6%, short-circuit current (Jsc) of 41.3 mA/cm2, and a conversion efficiencies (η) of 23.7%, showing that a lowly conducting and highly passivating intermediate layer between the p+ and n+ poly-Si regions is mandatory. Independent of the configuration, no hysteresis was observed upon multiple stresses in reverse direction, indicating a controlled and homogeneously distributed breakdown, but with different breakdown characteristics.

  19. Sequence analysis of the 3’-untranslated region of HSP70 (type I genes in the genus Leishmania: its usefulness as a molecular marker for species identification

    Directory of Open Access Journals (Sweden)

    Requena Jose M

    2012-04-01

    Full Text Available Abstract Background The Leishmaniases are a group of clinically diverse diseases caused by parasites of the genus Leishmania. To distinguish between species is crucial for correct diagnosis and prognosis as well as for treatment decisions. Recently, sequencing of the HSP70 coding region has been applied in phylogenetic studies and for identifying of Leishmania species with excellent results. Methods In the present study, we analyzed the 3’-untranslated region (UTR of Leishmania HSP70-type I gene from 24 strains representing eleven Leishmania species in the belief that this non-coding region would have a better discriminatory capacity for species typing than coding regions. Results It was observed that there was a remarkable degree of sequence conservation in this region, even between species of the subgenus Leishmania and Viannia. In addition, the presence of many microsatellites was a common feature of the 3´-UTR of HSP70-I genes in the Leishmania genus. Finally, we constructed dendrograms based on global sequence alignments of the analyzed Leishmania species and strains, the results indicated that this particular region of HSP70 genes might be useful for species (or species complex typing, improving for particular species the discrimination capacity of phylogenetic trees based on HSP70 coding sequences. Given the large size variation of the analyzed region between the Leishmania and Viannia subgenera, direct visualization of the PCR amplification product would allow discrimination between subgenera, and a HaeIII-PCR-RFLP analysis might be used for differentiating some species within each subgenera. Conclusions Sequence and phylogenetic analyses indicated that this region, which is readily amplified using a single pair of primers from both Old and New World Leishmania species, might be useful as a molecular marker for species discrimination.

  20. Catalogue of Workforce Information Sources: Decision Making Assistance for Regional Economic Development. U.S. Department of Labor, Employment and Training Administration

    Science.gov (United States)

    US Department of Labor, 2009

    2009-01-01

    In early 2006, The U.S. Department of Labor (DOL), Employment and Training Administration (ETA) began an initiative called Workforce Innovation in Regional Economic Development (WIRED) to help regions create competitive conditions, integrate economic and workforce development activities, and demonstrate that talent development can successfully…

  1. Assessment of undiscovered continuous oil and gas resources in the Domanik-type formations of the Volga-Ural Region Province, Russia, 2017

    Science.gov (United States)

    Klett, Timothy R.; Brownfield, Michael E.; Finn, Thomas M.; Gaswirth, Stephanie B.; Le, Phuong A.; Leathers-Miller, Heidi M.; Marra, Kristen R.; Mercier, Tracey J.; Pitman, Janet K.; Schenk, Christopher J.; Tennyson, Marilyn E.; Woodall, Cheryl A.

    2018-02-27

    Using a geology-based assessment methodology, the U.S. Geological Survey estimated mean undiscovered, technically recoverable continuous resources of 2.8 billion barrels of oil and 34 trillion cubic feet of gas in the Domanik-type formations of the Volga-Ural Region Province, Russia.

  2. Treatment of Patients With Complex Regional Pain Syndrome Type I With Mannitol: A Prospective, Randomized, Placebo-Controlled, Double-Blinded Study

    NARCIS (Netherlands)

    Perez, R.S.G.M.; Pragt, E.; Geurts, J.J.G.; Zuurmond, W.W.A.; Patijn, J.; van Kleef, M.

    2008-01-01

    To assess the effects of intravenous administration of the free radical scavenger mannitol 10% on complaints associated with complex regional pain syndrome Type I (CRPS I), a randomized, placebo-controlled, double-blinded trial was performed. Forty-one CRPS I patients according to the Bruehl et al

  3. Complex regional pain syndrome type I : Use of the International Association for the Study of Pain diagnostic criteria defined in 1994

    NARCIS (Netherlands)

    Reinders, M.F.; Geertzen, J.H.B.; Dijkstra, P.U.

    2002-01-01

    Objectives: The objective was to assess the reported use in recent publications of the diagnostic criteria for complex regional pain syndrome type I (CRPS 1) proposed by the International Association for the Study of Pain (IASP) in 1994. Methods: A literature search of MEDLINE (January 1996 to July

  4. Are regional variations in activity of dispatcher-assisted cardiopulmonary resuscitation associated with out-of-hospital cardiac arrests outcomes? A nation-wide population-based cohort study.

    Science.gov (United States)

    Nishi, Taiki; Kamikura, Takahisa; Funada, Akira; Myojo, Yasuhiro; Ishida, Tetsuya; Inaba, Hideo

    2016-01-01

    Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) impacts the rates of bystander CPR (BCPR) and survival after out-of-hospital cardiac arrests (OHCAs). This study aimed to elucidate whether regional variations in indexes for BCPR and emergency medical service (EMS) may be associated with OHCA outcomes. We conducted a population-based observational study involving 157,093 bystander-witnessed, resuscitation-attempted OHCAs without physician involvement between 2007 and 2011. For each index of BCPR and EMS, we classified the 47 prefectures into the following three groups: advanced, intermediate, and developing regions. Nominal logit analysis followed by multivariable logistic regression including OHCA backgrounds was employed to examine the association between neurologically favourable 1-month survival, and regional classifications based on BCPR- and EMS-related indexes. Logit analysis including all regional classifications revealed that the number of BLS training course participants per population or bystander's own performance of BCPR without DA-CPR was not associated with the survival. Multivariable logistic regression including the OHCA backgrounds known to be associated with survival (BCPR provision, arrest aetiology, initial rhythm, patient age, time intervals of witness-to-call and call-to-arrival at patient), the following regional classifications based on DA-CPR but not on EMS were associated with survival: sensitivity of DA-CPR [adjusted odds ratio (95% confidence intervals) for advanced region; those for intermediate region, with developing region as reference, 1.277 (1.131-1.441); 1.162 (1.058-1.277)]; the proportion of bystanders to follow DA-CPR [1.749 (1.554-1.967); 1.280 (1.188-1.380)]. Good outcomes of bystander-witnessed OHCAs correlate with regions having higher sensitivity of DA-CPR and larger proportion of bystanders to follow DA-CPR. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  5. Computational simulation of the microstructure of irradiation damaged regions for the plate type fuel of UO2 microspheres dispersed in stainless steel matrix

    International Nuclear Information System (INIS)

    Reis, S.C. dos; Lage, A.F.; Braga, D.; Ferraz, W.B.

    2006-01-01

    Plate type fuel elements have high efficiency of thermal transference what benefits the heat flux with high rates of power output. In reactor cores, fuel elements, in general, are subject to a high neutrons flux, high working temperatures, severe corrosion conditions, direct interference of fission products that result from nuclear reactions and radiation interaction-matter. For plate type fuels composed of ceramic particles dispersed in metallic matrix, one can observe the damage regions that arise due to the interaction fission products in the metallic matrix. Aiming at evaluating the extension of the damage regions in function of the particles and its diameters, in this paper, computational geometric simulations structure of plate type fuel cores, composed of UO 2 microspheres dispersed in stainless steel in several fractions of volume and diameters were carried out. The results of the simulations were exported to AutoCAD R where it was possible its visualization and analysis. (author)

  6. Burden and trends of type-specific human papillomavirus infections and related diseases in the latin america and Caribbean region.

    Science.gov (United States)

    Parkin, D Maxwell; Almonte, Maribel; Bruni, Laia; Clifford, Gary; Curado, Maria-Paula; Piñeros, Marion

    2008-08-19

    We present the burden of human papillomavirus (HPV)-related cancers (cancers of the cervix, anogenital region, oral cavity and pharynx) in terms of incidence and mortality, for the countries of the Latin America and Caribbean region. The region is a high-risk area for cancer of the cervix and, although incidence has declined since the 1960s, projected demographic changes imply that the actual burden of new cases will increase by more than 75% in the next 20 years, while the average and at diagnosis will increase. Approximately 65% of cervical cancer cases and 50% of the high risk lesions are associated with HPV-16 and 18. Incidence rates of other HPV-related cancers are significantly lower. The paper also describes the estimated impact of genital warts and the limited data available on the occurrence of HPV infections of the upper aerodigestive tract in the region.

  7. Soil respiration patterns for four major land-use types of the agro-pastoral region of northern China

    Science.gov (United States)

    Land-use types and management practices are critical factors that affect soil CO2 efflux (Rs). In the agro-pastoral area of northern China, land-use types have changed considerably during the last 60 years due to changes in the social-economic status of the human population and associated changes i...

  8. [Association between the types of obesity and the 10-year-coronary heart disease risk, in Tibet Autonomous Region and Xinjiang Uygur Autonomous Region].

    Science.gov (United States)

    Zheng, C Y; Wang, Z W; Chen, Z; Zhang, L F; Wang, X; Dong, Y; Nie, J Y; Wang, J L; Shao, L; Tian, Y

    2017-06-10

    Objective: To investigate the association between types of obesity and the 10-year-coronary heart disease risk in Tibet and Xinjiang of China. Methods: Using the multi-stage random sampling method, 7 631 participants aged 35 or older were examined under the International Standardized Examination process but with only 5 802 were eligible for analysis, in the 2015-2016 season. Results: The prevalence rates of general obesity, central obesity, visceral obesity and compound obesity were 0.53 % , 12.62 % , 10.08 % and 42.35 % , respectively. Out of all the compound obesity cases, 58.65 % (1 441/2 457) of them appeared as having all types of obesity in our study. Risk related to the 10-year-coronary heart disease was higher in men than in women [(3.05±4.14) % vs. (1.42±2.37) % , P obesity (30.16 % ) showed the highest proportion on the risk of 10-year-coronary heart disease than central obesity (28.01 % ), visceral obesity (18.46 % ) or the general obesity (19.35 % ). After adjustment for confounding factors, results from the multivariate analysis showed the risk in compound obesity was higher than central obesity, visceral obesity or general obesity and was associated with the highest risk on the 10-year-coronary heart disease ( OR =2.889, 95 %CI : 2.525-3.305). People with anomalous BMI and WC seemed to have had the higher risk ( OR =3.168, 95 %CI : 2.730-3.677). Conclusions: Obesity was popular in the residents of Tibet and Xinjiang areas of China. Men and people with compound obesity (especially both BMI and WC were abnormal) seemed to carry greater risk on the 10-year-coronary heart disease.

  9. Receptor type I and type II binding regions and the peptidyl-prolyl isomerase site of cyclophilin B are required for enhancement of T-lymphocyte adhesion to fibronectin.

    Science.gov (United States)

    Carpentier, Mathieu; Allain, Fabrice; Slomianny, Marie-Christine; Durieux, Sandrine; Vanpouille, Christophe; Haendler, Bernard; Spik, Geneviève

    2002-04-23

    Cyclophilin B (CyPB), a cyclosporin A (CsA) binding protein, interacts with two types of binding sites at the surface of T-lymphocytes. The type I sites correspond to functional receptors involved in endocytosis and the type II sites to sulfated glycosaminoglycans (GAGs). Mutational analysis of CyPB has revealed that W128, which is part of the CsA-binding pocket, is implicated in the binding to the functional type I receptors and that two amino acid clusters located in the N-terminus ensure the binding to GAGs. The peptidyl-prolyl isomerase activity of CyPB is not required for receptor binding. We have recently demonstrated that CyPB enhances adhesion of peripheral blood T-lymphocytes to fibronectin, a component of the extracellular matrix. We intended to identify additional amino acids involved in the binding of CyPB to its functional type I receptor and to determine regions responsible for the stimulation of peripheral blood T-lymphocyte adhesion. We determined that residues R76, G77, K132, D155, and D158 of the calcineurin (CN) interacting region were implicated in the recognition of type I receptor but not of GAGs. We also found that two different changes in the N-terminal extension that abated binding to GAGs prevented adhesion of peripheral blood T-lymphocytes to coated CyPB, whereas abbrogation of the PPIase activity had no effect. On the other hand, the adhesion of peripheral blood T-lymphocytes to coated fibronectin was not stimulated by CyPB mutants devoid of either type I receptor or GAGs binding activity or by mutants of the PPIase site. Altogether, the results demonstrate that different regions of CyPB are involved in peripheral blood T-lymphocyte activation and imply a novel important physiological function for peptidyl-prolyl isomerase activity.

  10. Assistance Focus: Africa

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-18

    The Clean Energy Solutions Center, an initiative of the Clean Energy Ministerial, helps countries throughout the world create policies and programs that advance the deployment of clean energy technologies. Through the Solutions Center's no-cost Ask an Expert service, a team of international experts has delivered assistance to countries in all regions of the world, including Africa.

  11. Regional cerebral blood flow and its correlation with clinical assessment in senile dementia of Alzheimer type and multi-infarct dementia

    International Nuclear Information System (INIS)

    Shinohara, Masao; Kawakatsu, Shinobu; Morinobu, Shigeru; Oiji, Arata; Sagawa, Katsuo; Yazaki, Mitsuyasu; Totsuka, Shirou; Komatani, Akio; Yamaguchi, Koichi

    1989-01-01

    Twenty-one patients with senile dementia of Alzheimer type (SDAT), 11 patients with multi-infarct dementia (MID), and 6 healthy volunteers were examined by SPECT using Xe-inhalation method. These patients also underwent an intelligence test according to the Gottfries-Brane-Steen (GBS) scale. Patients with mild SDAT did not have a significantly decreased regional cerebral blood flow (rCBF). In moderate or severe cases, however, a significantly decreased rCBF was bilaterally observed in all regions, except for the basal ganglia. This was marked in the temporoparietal region. A group of moderate or severe MID patients had a significantly decreased rCBF especially in the basal ganglia. It was also observed in the temporoparietal region, but not in the frontal region. Among the SDAT patients, there was a good correlation between rCBF and GBS scale in all the regions, except for the basal ganglia. In the case of MID patients, correlations were observed both between rCBF in the left side of the brain and clinical findings according to the method of Hasegawa and between rCBF in the right side of the frontal region and the motor function on the GBS scale. These findings may have implications for the different pathophysiology between SDAT and MID. (N.K.)

  12. International assistance. Licensing assistance project

    International Nuclear Information System (INIS)

    Aleev, A.

    1999-01-01

    Description of licensing assistance project for VATESI is presented. In licensing of unit No.1 of INPP VATESI is supported by many western countries. Experts from regulatory bodies or scientific organizations of those countries assist VATESI staff in reviewing documentation presented by INPP. Among bilateral cooperation support is provided by European Commission through Phare programme

  13. Analysis of Regional Cerebral Blood Flow Using 99mTc-HMPAO Brain SPECT in Senile Dementia of Alzheimer Type

    International Nuclear Information System (INIS)

    Lee, Myung Hae; Lee, Myung Chul; Koh, Chang Soon; Roh, Jae Kyu; Woo, Chong In

    1988-01-01

    99m Tc-HMPAO brain SPECT studies were performed in 11 patients with Alzheimer's disease, 7 patients with psychological depression and 12 normal controls. Changes of regional cerebral blood flow was semiquantitatively analyzed and the results were as follows. 1) In 11 patients with Alzheimer's disease, significant reduction of regional cerebral blood flow was found In both temporoparietal areas. 2) Relative perfusion between cerebral hemispheres was rather symmetrical in patient with Alzheimer's disease. 3) All patients with depression showed normal SPECT findings. As for conclusion, 99m Tc-HMPAO brain SPECT seemed to be a valuable method for clinical assessment and management of patients with Alzheimer's disease.

  14. Improved Ohmic-contact to AlGaN/GaN using Ohmic region recesses by self-terminating thermal oxidation assisted wet etching technique

    Science.gov (United States)

    Liu, J.; Wang, J.; Wang, H.; Zhu, L.; Wu, W.

    2017-06-01

    Lower Ti/Al/Ni/Au Ohmic contact resistance on AlGaN/GaN with wider rapid thermal annealing (RTA) temperature window was achieved using recessed Ohmic contact structure based on self-terminating thermal oxidation assisted wet etching technique (STOAWET), in comparison with conventional Ohmic contacts. Even at lower temperature such as 650°C, recessed structure by STOAWET could still obtain Ohmic contact with contact resistance of 1.97Ω·mm, while conventional Ohmic structure mainly featured as Schottky contact. Actually, both Ohmic contact recess and mesa isolation processes could be accomplished by STOAWET in one process step and the process window of STOAWET is wide, simplifying AlGaN/GaN HEMT device process. Our experiment shows that the isolation leakage current by STOAWET is about one order of magnitude lower than that by inductivity coupled plasma (ICP) performed on the same wafer.

  15. Ru(II)-Catalyzed Oxidative Heck-Type Olefination of Aromatic Carboxylic Acids with Styrenes through Carboxylate-Assisted C-H Bond Activation.

    Science.gov (United States)

    Dana, Suman; Mandal, Anup; Sahoo, Harekrishna; Mallik, Sumitava; Grandhi, Gowri Sankar; Baidya, Mahiuddin

    2018-02-02

    A straightforward synthesis of 2-styrylbenzoic acids from aryl carboxylic acids is disclosed through a carboxylate-assisted coupling under Ru(II) catalysis. This protocol is simple and exhibits broad scope with high tolerance of common organic functional groups, providing good to excellent yields of diverse olefinated products. The efficacy of this protocol has been showcased through sequential syntheses of isochromanone, isocoumarin, and formal synthesis of anacardic acid derivative in good yields.

  16. Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region.

    Science.gov (United States)

    Ahn, Yu Mi; Clare, Michael; Ensinger, Carol L; Hood, Molly M; Lord, John W; Lu, Wei-Ping; Miller, David F; Patt, William C; Smith, Bryan D; Vogeti, Lakshminarayana; Kaufman, Michael D; Petillo, Peter A; Wise, Scott C; Abendroth, Jan; Chun, Lawrence; Clark, Robin; Feese, Michael; Kim, Hidong; Stewart, Lance; Flynn, Daniel L

    2010-10-01

    Switch control pocket inhibitors of p38-alpha kinase are described. Durable type II inhibitors were designed which bind to arginines (Arg67 or Arg70) that function as key residues for mediating phospho-threonine 180 dependant conformational fluxing of p38-alpha from an inactive type II state to an active type I state. Binding to Arg70 in particular led to potent inhibitors, exemplified by DP-802, which also exhibited high kinase selectivity. Binding to Arg70 obviated the requirement for binding into the ATP Hinge region. X-ray crystallography revealed that DP-802 and analogs induce an enhanced type II conformation upon binding to either the unphosphorylated or the doubly phosphorylated form of p38-alpha kinase. Copyright © 2010 Elsevier Ltd. All rights reserved.

  17. Solutions for Determining the Significance Region Using the Johnson-Neyman Type Procedure in Generalized Linear (Mixed) Models

    Science.gov (United States)

    Lazar, Ann A.; Zerbe, Gary O.

    2011-01-01

    Researchers often compare the relationship between an outcome and covariate for two or more groups by evaluating whether the fitted regression curves differ significantly. When they do, researchers need to determine the "significance region," or the values of the covariate where the curves significantly differ. In analysis of covariance (ANCOVA),…

  18. Contribution of Alpha and Beta Diversity Across Land-Use Type to the Regional Diversity of Dung Beetles in Central Sulawesi

    Directory of Open Access Journals (Sweden)

    SHAHABUDDIN

    2013-06-01

    Full Text Available The importance of spatial scale has been acknowledged as one of determining factors of species diversity in local and regional diversity. The aim of this study was to evaluate contribution of alpha (α and beta (β diversity across land-use type to gamma (γ diversity at the margins of tropical forest in Central Sulawesi using dung beetles (Coleoptera: Scarabaeidae as a focal group. Baited pitfall traps set in four land-use types ranging from natural forest through cacao agroforestry systems to open areas during two years of sampling (2009 and 2012. A total of 28 dung beetle species belonging to four genera were captured during the study period. The results showed that contribution of β diversity was higher than that of α diversity of dung beetles. Each land-use type contributed about 56.5 to 62.5% of the total species richness (γ diversity. The similar pattern of biodiversity between each spatial scale and during the two sampling years emphasized the large contribution of each land-use type to maintaining a high portion of the regional species richness. It suggests the importance of managing other land-use types, such as secondary forest and agroforestry as well as protecting the remaining natural forests.

  19. [DETERMINATION OF TYPES OF EPIDEMIC MANIFESTATIONS OF CHOLERA IN REGIONS OF THE CRIMEA FEDERAL DISTRICT (REPUBLIC OF CRIMEA)].

    Science.gov (United States)

    Onischenko, G G; Popova, A Yu; Moskvitina, E A; Penkovskaya, N A; Listopad, S A; Titova, S V; Kruglikov, V D

    2015-01-01

    The aim of the study was determination of the type of epidemic manifestations of cholera in the Republic of Crimea based on evaluation of epidemic manifestations of cholera risk of introduction and spread of the infection. It was concluded, that, based on the cholera outbreaks, that had taken place, contamination of surface water bodies (fresh and sea) and sewage by Vibrio cholerae O1 ctxA+ and Vibrio cholerae O1 ctXA- potential epidemic danger of introduction of the infection by various types of international transport, population migration, the presence of epidemiologic risk in realization of water pathway of transmission of cholera causative agent and several other social conditions, the Republic of Crimea remains in the group of territories of type I by epidemic manifestations of cholera.

  20. Computer-assisted segmentation of CT images by statistical region merging for the production of voxel models of anatomy for CT dosimetry

    Czech Academy of Sciences Publication Activity Database

    Caon, M.; Sedlář, Jiří; Bajger, M.; Lee, G.

    2014-01-01

    Roč. 37, č. 2 (2014), s. 393-403 ISSN 0158-9938 Institutional support: RVO:67985556 Keywords : Voxel model * Image segmentation * Statistical region merging * CT dosimetry Subject RIV: JD - Computer Applications, Robotics Impact factor: 0.882, year: 2014 http://library.utia.cas.cz/separaty/2014/ZOI/sedlar-0428537.pdf

  1. Construction of rat cell lines that contain potential morphologically transforming regions of the herpes simplex virus type 2 genome

    NARCIS (Netherlands)

    van den Berg, F. M.; van Amstel, P. J.; Walboomers, J. M.

    1985-01-01

    Hybrid recombinant plasmids were constructed; they were composed of the herpes simplex virus type 2 (HSV2) thymidine kinase (tk) gene and DNA sequences of HSV2 that have been reported to induce morphological and/or oncogenic transformation of rodent cells in culture. Several plasmids were made in

  2. Do non-profit sport organisations innovate? Types and preferences of service innovation within regional sport federations

    NARCIS (Netherlands)

    Winand, M.; Scheerder, J.; Vos, S.B.; Zint, T.

    2016-01-01

    Little is known about innovation in the non-profit sport sector. The current research addresses this gap by questioning whether and to what extent sport federations innovate. It aims to identify types of innovation implemented by sport federations and their attitude and preferences towards

  3. HPV prevalence and type distribution in women with or without cervical lesions in the Northeast region of Romania

    Science.gov (United States)

    2011-01-01

    Background Cervical cancer is a major public health problem worldwide. While Romania has the highest incidence of cervical cancer in Europe, the prevalence of HPV has not been evaluated. We report the first data on HPV prevalence and type distribution in Northeast Romania. Methods HPV prevalence and genotype distribution was investigated in 514 consecutively women with or without cervical lesions in Northeast Romania. Genotyping was performed with Linear Array Genotyping/Roche kit. Results In our study group, 192/514 (37.4%) patients were positive for HPV (infected with single and with multiple HPV types). Most frequent types were: 16 (10.5%), 53 (5.44%), 51 (5.05%), 52 (4.08%) 18 (2.91%) and 31 (2.73%). Conclusions Infection with high risk types of HPV is common in Northeast Romania. Enhanced and systematic screening for cervical cancer is needed. Our results call for the implementation of a National HPV vaccine program in Romania. PMID:22192090

  4. Historical changes in dispersed kopanitse land type and changes in use of agricultural land on Kysuce region example

    Directory of Open Access Journals (Sweden)

    Barančok Peter

    2016-12-01

    Full Text Available Territory of Kysuce is characterised by a high proportion of the traditional agricultural landscape (TAL, which occupy almost 12% of the area. Two types of TAL were allocated here. The first type is represented by TAL with dispersed settlement. The second type is represented by TAL of arable land and grassland landscape. The largest representation has typical forms of anthropogenic relief (FAR. TALs represent the most diverse mosaic of man-made habitats and natural habitats too. In the past, there were the largest representations of arable land and regularly mown meadows. Currently, these areas are dominated by abandoned meadows (fallow meadows, occasionally grazed pastures and meadows. Arable land is represented only minimally. The large part of areas is overgrown by non-forest woody vegetation or passes to the forest vegetation. In this process of landscape changes, significant changes in biodiversity of the areas are realised. Successively, the species of segetal and ruderal vegetation are less represented and species of forest vegetation obtained greater representation. In the process of mapping and evaluation, FAR - shape and orientation of plots, types of balks and some of their basic characteristics - were monitored.

  5. Links between circulation types and precipitation in Central Europe in the observed data and regional climate model simulations

    Czech Academy of Sciences Publication Activity Database

    Plavcová, Eva; Kyselý, Jan; Štěpánek, P.

    2014-01-01

    Roč. 34, č. 9 (2014), s. 2885-2898 ISSN 0899-8418 R&D Projects: GA ČR GAP209/10/2265 Grant - others:FP6 ENSEMBLES(XE) 505539 Program:FP6 Institutional support: RVO:68378289 Keywords : precipitation * atmospheric circulation * regional climate models * ENSEMBLES * Central Europe Subject RIV: DG - Athmosphere Sciences, Meteorology; DG - Athmosphere Sciences, Meteorology (UEK-B) Impact factor: 3.157, year: 2014

  6. Evidence for a Rayleigh-Taylor type instability and upwelling of depleted density regions during equatorial spread F

    Science.gov (United States)

    Kelley, M. C.; Haerendel, G.; Kappler, H.; Valenzuela, A.; Balsley, B. B.; Carter, D. A.; Ecklund, W. L.; Carlson, C. W.; Haeusler, B.; Torbert, R.

    1976-01-01

    Recent rocket probe, barium cloud and radar measurements conducted during equatorial spread F conditions are interpreted in terms of a Rayleigh-Taylor gravitational instability operating on the bottomside of the F peak. The persistent theoretical problems associated with strong radar echoes typically observed in patch-like structures at high altitudes are explained in terms of regions of depleted plasma density which buoyantly rise against the gravitational field.

  7. Evidence for a Rayleigh-Taylor type instability and upwelling of depleted density regions during equatorial spread F

    International Nuclear Information System (INIS)

    Kelley, M.C.; Haerendel, G.; Kappler, H.; Valenzuela, A.; Balsley, B.B.; Carter, D.A.; Ecklund, W.L.; Carlson, C.W.; Hausler, B.; Torbert, R.

    1976-01-01

    Recent rocket probe, barium cloud and radar measurements conducted during equatorial spread F conditions are interpreted in terms of a Rayleigh-Taylor gravitational instability operating on the bottomside of the F peak. The persistent theoretical problems associated with strong radar echoes typically observed in patch-like structures at high altitudes are explained in terms of regions of depleted plasma density which bouyantly rise against the gravitational field

  8. Hosts and vectors of Trypanosoma cruzi discrete typing units in the Chagas disease endemic region of the Paraguayan Chaco

    OpenAIRE

    ACOSTA, NIDIA; L?PEZ, ELSA; LEWIS, MICHAEL D.; LLEWELLYN, MARTIN S.; G?MEZ, ANA; ROM?N, FABIOLA; MILES, MICHAEL A.; YEO, MATTHEW

    2017-01-01

    SUMMARY Active Trypanosoma cruzi transmission persists in the Gran Chaco region, which is considered hyperendemic for Chagas disease. Understanding domestic and sylvatic transmission cycles and therefore the relationship between vectors and mammalian hosts is crucial to designing and implementing improved effective control strategies. Here we describe the species of triatomine vectors and the sylvatic mammal reservoirs of T. cruzi, in different localities of the Paraguayan and Bolivian Chaco....

  9. The National and Regional Prevalence Rates of Disability, Type, of Disability and Severity in Saudi Arabia-Analysis of 2016 Demographic Survey Data.

    Science.gov (United States)

    Bindawas, Saad M; Vennu, Vishal

    2018-02-28

    The prevalence of disability varies between countries ranging from less than 1% to up to 30% in some countries, thus, the estimated global disability prevalence is about 15%. However, it is unknown what the current estimate of disability and its types and severity are in Saudi Arabia. Thus, the objective of this study is to estimate national and regional prevalence rates of any disability, types of disability, and their severity among Saudi populations. Data on disability status were extracted from the national demographic survey conducted in 2016 as reported by the General Authority for Statistics, Saudi Arabia (N = 20,064,970). Prevalence rates per a population of 100,000 of any disability, type of disability, and its severity were calculated at the national level and in all 13 regions. Out of 20,064,970 Saudi citizens surveyed, 667,280 citizens reported disabilities, accounting for a prevalence rate of 3326 per a population of 100,000 (3.3%). Individuals aged 60 years and above (11,014) and males (3818) had a higher prevalence rate of disability compared with females (2813). The Tabuk region has the highest rate of reported disability, at 4.3%. The prevalence rates of extreme disabilities in mobility and sight were higher in Madinah (57,343) and Northern border (41,236) regions, respectively. In Saudi Arabia, more than half a million Saudi citizens (1 out of every 30 individuals) reported the presence of disability during the year 2016. A higher prevalence rate of disability was seen among those aged 60 years and above, and males. Targeted efforts are required at the national and regional levels to expand and improve rehabilitation and social services for all people with disabilities.

  10. Identification of a 450-bp region of human papillomavirus type 1 that promotes episomal replication in Saccharomyces cerevisiae

    International Nuclear Information System (INIS)

    Chattopadhyay, Anasuya; Schmidt, Martin C.; Khan, Saleem A.

    2005-01-01

    Human papillomaviruses (HPVs) replicate as nuclear plasmids in infected cells. Since the DNA replication machinery is generally conserved between humans and Saccharomyces cerevisiae, we studied whether HPV-1 DNA can replicate in yeast. Plasmids containing a selectable marker (with or without a yeast centromere) and either the full-length HPV-1 genome or various regions of the viral long control region (LCR) and the 3' end of the L1 gene were introduced into S. cerevisiae and their ability to replicate episomally was investigated. Our results show that HPV-1 sequences promote episomal replication of plasmids although the yeast centromere is required for plasmid retention. We have mapped the autonomously replicating sequence activity of HPV-1 DNA to a 450 base-pair sequence (HPV-1 nt 6783-7232) that includes 293 nucleotides from the 5' region of the viral LCR and 157 nucleotides from the 3' end of the L1 gene. The HPV-1 ARS does not include the binding sites for the viral E1 and E2 proteins, and these proteins are dispensable for replication in S. cerevisiae

  11. Effects of different types of anaesthesia (regional vs general) on serum NO and TNF-α levels in surgical patients

    International Nuclear Information System (INIS)

    Li Hong

    2006-01-01

    Objective: To study the effect of anesthesia on changes of serum NO and TNF-α levels in surgical patients. Methods: Serum NO (with biochemical method) and TNF-α (with RIA) levels were determined for 3 times in 31 patients operated under regional anesthesia and 31 patients operated under general anesthesia (both for benign gastric ulcer). The levels were measured before induction of anesthesia, at the beginning of operation, and 1 hr later. Results: In patients under regional anesthesia, both the NO and TNF-α levels increased significantly at the beginning of operation and, 1 hr later, though dropped, remained significantly higher than the levels before induction (P<0.05). NO significant changes of the levels were observed in patients under general anesthesia throughout the operation, and the levels were, as a whole, significantly lower than the levels under regional anesthesia (P<0.05). Conclusion: General anesthesia (combined intravenous and inhalation) could abolish the increase of serum NO and TNF-α levels duning operation. (authors)

  12. Are Pain-Related Fears Mediators for Reducing Disability and Pain in Patients with Complex Regional Pain Syndrome Type 1? An Explorative Analysis on Pain Exposure Physical Therapy

    Science.gov (United States)

    Barnhoorn, Karlijn J.; Staal, J. Bart; van Dongen, Robert T. M.; Frölke, Jan Paul M.; Klomp, Frank P.; van de Meent, Henk; Samwel, Han; Nijhuis-van der Sanden, Maria W. G.

    2015-01-01

    Objective To investigate whether pain-related fears are mediators for reducing disability and pain in patients with Complex Regional Pain Syndrome type 1 when treating with Pain Exposure Physical Therapy. Design An explorative secondary analysis of a randomised controlled trial. Participants Fifty-six patients with Complex Regional Pain Syndrome type 1. Interventions The experimental group received Pain Exposure Physical Therapy in a maximum of five treatment sessions; the control group received conventional treatment following the Dutch multidisciplinary guideline. Outcome measures Levels of disability, pain, and pain-related fears (fear-avoidance beliefs, pain catastrophizing, and kinesiophobia) were measured at baseline and after 3, 6, and 9 months follow-up. Results The experimental group had a significantly larger decrease in disability of 7.77 points (95% CI 1.09 to 14.45) and in pain of 1.83 points (95% CI 0.44 to 3.23) over nine months than the control group. The potential mediators pain-related fears decreased significantly in both groups, but there were no significant differences between groups, which indicated that there was no mediation. Conclusion The reduction of pain-related fears was comparable in both groups. We found no indication that pain-related fears mediate the larger reduction of disability and pain in patients with Complex Regional Pain Syndrome type 1 treated with Pain Exposure Physical Therapy compared to conventional treatment. Trial registration International Clinical Trials Registry NCT00817128 PMID:25919011

  13. Bisphosphonates for treatment of Complex Regional Pain Syndrome type 1: A systematic literature review and meta-analysis of randomized controlled trials versus placebo.

    Science.gov (United States)

    Chevreau, Maxime; Romand, Xavier; Gaudin, Philippe; Juvin, Robert; Baillet, Athan

    2017-07-01

    Complex Regional Pain Syndrome Type 1 is a severely disabling pain syndrome with no definite established treatment. We have performed a systematic literature review and meta-analysis of all randomized controlled trials to assess the benefit of bisphosphonates on pain and function in patients with Complex Regional Pain Syndrome Type 1. A systematic literature search was performed in the Medline, Embase and Cochrane databases. Two authors selected independently blinded randomized trials comparing bisphosphonates to placebo on short-term (J30 to J40) and medium term pain (M2-M3), safety and function in patients with CRPS 1. The methodological quality of the studies was analyzed. Data were aggregated using the method of the inverse of the variance. 258 articles were identified. Four trials of moderate to good quality comprising 181 patients (90 in the bisphosphonate group and 91 in the placebo group) were included in this meta-analysis. Short-term pain Visual Analog Scale was significantly lower in the bisphosphonate group versus the placebo group (SMD=-2.6, 95%CI [-1.8, -3.4], Ppain (SMD=-2.5, 95%CI [-1.4, -3.6], Ppain in patients with Complex Regional Pain Syndrome type 1. Other studies are needed to determine their effectiveness. Copyright © 2017. Published by Elsevier SAS.

  14. A novel type of matrix for surface-assisted laser desorption-ionization mass spectrometric detection of biomolecules using metal-organic frameworks.

    Science.gov (United States)

    Fu, Chien-Ping; Lirio, Stephen; Liu, Wan-Ling; Lin, Chia-Her; Huang, Hsi-Ya

    2015-08-12

    A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Male sex, height, weight, and body mass index can increase external pressure to calf region using knee-crutch-type leg holder system in lithotomy position.

    Science.gov (United States)

    Mizuno, Ju; Takahashi, Toru

    2016-01-01

    Well-leg compartment syndrome (WLCS) is one of the catastrophic complications related to prolonged surgical procedures performed in the lithotomy position, using a knee-crutch-type leg holder (KCLH) system, to support the popliteal fossae and calf regions. Obesity has been implicated as a risk factor in the lithotomy position-related WLCS during surgery. In the present study, we investigated the relationship between the external pressure (EP) applied to the calf region using a KCLH system in the lithotomy position and selected physical characteristics. Twenty-one young, healthy volunteers (21.4±0.5 years of age, eleven males and ten females) participated in this study. The KCLH system used was Knee Crutch(®). We assessed four types of EPs applied to the calf region: box pressure, peak box pressure, contact pressure, and peak contact pressure, using pressure-distribution measurement system (BIG-MAT(®)). Relationships between these four EPs to the calf regions of both lower legs and a series of physical characteristics (sex, height, weight, and body mass index [BMI]) were analyzed. All four EPs applied to the bilateral calf regions were higher in males than in females. For all subjects, significant positive correlations were observed between all four EPs and height, weight, and BMI. EP applied to the calf region is higher in males than in females when the subject is supported by a KCLH system in the lithotomy position. In addition, EP increases with the increase in height, weight, and BMI. Therefore, male sex, height, weight, and BMI may contribute to the risk of inducing WLCS.

  16. Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling

    OpenAIRE

    Melki, Isabelle; Rose, Yoann; Uggenti, Carolina; Van Eyck, Lien; Frémond, Marie-Louise; Kitabayashi, Naoki; Rice, Gillian I; Jenkinson, Emma M; Boulai, Anaïs; Jeremiah, Nadia; Gattorno, Marco; Volpi, Sefano; Sacco, Olivero; Terheggen-Lagro, Suzanne W J; Tiddens, Harm A W M

    2017-01-01

    BACKGROUND: Gain-of-function mutations in transmembrane protein 173 (TMEM173) encoding stimulator of interferon genes (STING) underlie a recently described type I interferonopathy called STING-associated vasculopathy with onset in infancy (SAVI).OBJECTIVES: We sought to define the molecular and cellular pathology relating to 3 individuals variably exhibiting the core features of the SAVI phenotype including systemic inflammation, destructive skin lesions, and interstitial lung disease.METHODS...

  17. Single nucleotide polymorphism typing of Mycobacterium ulcerans reveals focal transmission of buruli ulcer in a highly endemic region of Ghana.

    Directory of Open Access Journals (Sweden)

    Katharina Röltgen

    Full Text Available Buruli ulcer (BU is an emerging necrotizing disease of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. While proximity to stagnant or slow flowing water bodies is a risk factor for acquiring BU, the epidemiology and mode of M. ulcerans transmission is poorly understood. Here we have used high-throughput DNA sequencing and comparisons of the genomes of seven M. ulcerans isolates that appeared monomorphic by existing typing methods. We identified a limited number of single nucleotide polymorphisms (SNPs and developed a real-time PCR SNP typing method based on these differences. We then investigated clinical isolates of M. ulcerans on which we had detailed information concerning patient location and time of diagnosis. Within the Densu river basin of Ghana we observed dominance of one clonal complex and local clustering of some of the variants belonging to this complex. These results reveal focal transmission and demonstrate, that micro-epidemiological analyses by SNP typing has great potential to help us understand how M. ulcerans is transmitted.

  18. Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling.

    Science.gov (United States)

    Melki, Isabelle; Rose, Yoann; Uggenti, Carolina; Van Eyck, Lien; Frémond, Marie-Louise; Kitabayashi, Naoki; Rice, Gillian I; Jenkinson, Emma M; Boulai, Anaïs; Jeremiah, Nadia; Gattorno, Marco; Volpi, Sefano; Sacco, Olivero; Terheggen-Lagro, Suzanne W J; Tiddens, Harm A W M; Meyts, Isabelle; Morren, Marie-Anne; De Haes, Petra; Wouters, Carine; Legius, Eric; Corveleyn, Anniek; Rieux-Laucat, Frederic; Bodemer, Christine; Callebaut, Isabelle; Rodero, Mathieu P; Crow, Yanick J

    2017-08-01

    Gain-of-function mutations in transmembrane protein 173 (TMEM173) encoding stimulator of interferon genes (STING) underlie a recently described type I interferonopathy called STING-associated vasculopathy with onset in infancy (SAVI). We sought to define the molecular and cellular pathology relating to 3 individuals variably exhibiting the core features of the SAVI phenotype including systemic inflammation, destructive skin lesions, and interstitial lung disease. Genetic analysis, conformational studies, in vitro assays and ex vivo flow-cytometry were performed. Molecular and in vitro data demonstrate that the pathology in these patients is due to amino acid substitutions at positions 206, 281, and 284 of the human STING protein. These mutations confer cGAMP-independent constitutive activation of type I interferon signaling through TBK1 (TANK-binding kinase), independent from the alternative STING pathway triggered by membrane fusion of enveloped RNA viruses. This constitutive activation was abrogated by ex vivo treatment with the janus kinase 1/2 inhibitor ruxolitinib. Structural analysis indicates that the 3 disease-associated mutations at positions 206, 281, and 284 of the STING protein define a novel cluster of amino acids with functional importance in the regulation of type I interferon signaling. Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  19. Fabrication of low reflective nanopore-type black Si layer using one-step Ni-assisted chemical etching for Si solar cell application

    Science.gov (United States)

    Takaloo, AshkanVakilipour; Kolahdouz, Mohammadreza; Poursafar, Jafar; Es, Firat; Turan, Rasit; Ki-Joo, Seung

    2018-03-01

    Nanotextured Si fabricated through metal-assisted chemical etching (MACE) technique exhibits a promising potential for producing antireflective layer for photovoltaic (PV) application. In this study, a novel single-step nickel (Ni) assisted etching technique was applied to produce an antireflective, nonporous Si (black Si) in an aqueous solution containing hydrofluoric acid (HF), hydrogen peroxide (H2O2) and NiSO4 at 40 °C. Field emission scanning electron microscope was used to characterize different morphologies of the textured Si. Optical reflection measurements of samples were carried out to compare the reflectivity of different morphologies. Results indicated that vertical as well as horizontal pores with nanosized diameters were bored in the Si wafer after 1 h treatment in the etching solution containing different molar ratios of H2O2 to HF. Increasing H2O2 concentration in electrochemical etching solution had a considerable influence on the morphology due to higher injection of positive charges from Ni atoms onto the Si surface. Optimized concentration of H2O2 led to formation of an antireflective layer with 2.1% reflectance of incident light.

  20. Comparison and Application of Two types of Filling Gel to Prevent Spontaneous Combustion at the Region where Top-Coal Caves above Entry

    Directory of Open Access Journals (Sweden)

    Wang Yuhuai

    2016-01-01

    Full Text Available Two types of gel were developed, by taking fly ash and foaming cement as aggregate, which is usually used as filling material at the region where top-coal caves above coal entry in the Jinggezhuang coal mine, and adding high molecular polymer and bio-gel as additive. Sweating rates of the two types of gel under various matching ratio and temperature were tested. And then sweating ratio and water retention ratio of the two gels were calculated, based on which, the optimized matching ratios, were determined. Viscosity indexes of the two-type gel under different ratios were tested. The optimized filling ratios of the two types of gel were determined according to the two indexes, water retention rate and the viscosity. The filling experiments were implemented and evaluated in site, the Jinggezhuang coal mine. The results show that the fly ash gel has a good achievement on preventing spontaneous combustion at the Region where Top-Coal Caves above entries. It is promising, economically and environmental friendly, and valuable in popularization in coal mines.

  1. Hydrogeological analysis applied to regional evaluation of sandstone-type uranium ore-formation in sedimentary basins

    International Nuclear Information System (INIS)

    Xu Laisheng

    2005-01-01

    The main purpose of regional evaluation of uranium ore-formation is to preliminarily divide environmental zones and to delineate favourable areas for uranium ore-formation in order to provide basis for further detailed prospecting work. Of the various kinds of prospecting work, the hydrogeologic work should be mainly carried out in following aspects: division of hydrogeological units, the determination of artesian water-bearing system and the identification of prospecting target horizon; the analysis on hydrodynamic regime, the analysis on hydrogeochemical environments, the paleo-hydrogeologic analysis and the delineation of redox front and favourable area for uranium ore-formation. (author)

  2. Trypanosoma cruzi strains isolated from human, vector, and animal reservoir in the same endemic region in Mexico and typed as T. cruzi I, discrete typing unit 1 exhibit considerable biological diversity

    Directory of Open Access Journals (Sweden)

    María del Carmen Sánchez-Guillén

    2006-09-01

    Full Text Available In this study, three strains of Trypanosoma cruzi were isolated at the same time and in the same endemic region in Mexico from a human patient with chronic chagasic cardiomyopathy (RyC-H; vector (Triatoma barberi (RyC-V; and rodent reservoir (Peromyscus peromyscus (RyC-R. The three strains were characterized by multilocus enzyme electrophoresis, random amplified polymorphic DNA, and by pathological profiles in experimental animals (biodemes. Based on the analysis of genetic markers the three parasite strains were typed as belonging to T. cruzi I major group, discrete typing unit 1. The pathological profile of RyC-H and RyC-V strains indicated medium virulence and low mortality and, accordingly, the strains should be considered as belonging to biodeme Type III. On the other hand, the parasites from RyC-R strain induced more severe inflammatory processes and high mortality (> 40% and were considered as belonging to biodeme Type II. The relationship between genotypes and biological characteristics in T. cruzi strains is still debated and not clearly understood. An expert committee recommended in 1999 that Biodeme Type III would correspond to T. cruzi I group, whereas Biodeme Type II, to T. cruzi II group. Our findings suggest that, at least for Mexican isolates, this correlation does not stand and that biological characteristics such as pathogenicity and virulence could be determined by factors different from those identified in the genotypic characterization

  3. Pollen types and levels of total phenolic compounds in propolis produced by Apis mellifera L. (Apidae in an area of the Semiarid Region of Bahia, Brazil

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    VANESSA R. MATOS

    2014-03-01

    Full Text Available Twenty-two propolis samples produced by Apis mellifera L. in an area of the Semiarid region the the State of Bahia (Agreste of Alagoinhas, Brazil, were palynologically analyzed and quantified regarding their levels of total phenolic compounds. These samples were processed using the acetolysis technique with the changes suggested for use with propolis. We found 59 pollen types belonging to 19 families and 36 genera. The family Fabaceae was the most representative in this study with nine pollen types, followed by the family Asteraceae with seven types. The types Mikania and Mimosa pudica occurred in all samples analyzed. The types Mimosa pudica and Eucalyptus had frequency of occurrence above 50% in at least one sample. The highest similarity index (c. 72% occurred between the samples ER1 and ER2, belonging to the municipality of Entre Rios. Samples from the municipality of Inhambupe displayed the highest (36.78±1.52 mg/g EqAG and lowest (7.68 ± 2.58 mg/g EqAG levels of total phenolic compounds. Through the Spearman Correlation Coefficient we noticed that there was a negative linear correlation between the types Mimosa pudica (rs = -0.0419 and Eucalyptus (rs = -0.7090 with the profile of the levels of total phenolic compounds of the samples.

  4. The T-cell receptor beta chain CDR3 region of BV8S1/BJ1S5 transcripts in type 1 diabetes.

    Science.gov (United States)

    Naserke, H E; Durinovic-Bellò, I; Seidel, D; Ziegler, A G

    1996-01-01

    We recently described the T-cell receptor (TCR) beta chain CDR3 motif S-SDRLG-NQPQH (BV8S1-BJ1S5) in an islet-specific T-cell clone (K2.12) from a type 1 diabetic patient (AS). A similar motif (RLGNQ) was also reported in a T-cell clone of non-obese diabetic (NOD) mice by others. In order to determine the frequency of our motif in selected and unselected T-cell populations, we cloned and sequenced the CDR3 region of BV8S1-BJ1S5 transcripts. These transcripts were derived from unstimulated peripheral blood T lymphocytes from two type 1 diabetic patients (AS and FS) and their non-diabetic sibling (WS), as well as from an islet-specific T-cell line of one of the patients. In addition, we compared the structure and composition of the CDR3 region in BV8S1-BJ1S5 transcripts from peripheral blood T cells between the patients and their non-diabetic sibling (>50 sequences each). We found that 30% of the islet-specific T-cell line cDNA clones expressed the entire sequence-motif, whereas it was absent in the clones of unstimulated peripheral blood T cells from both patients and their non-diabetic sibling. The average length of the CDR3 region was shorter in the patients (mean AS 9.9, FS 9.9, versus WS 10.7, p = 0.0037) and the number of inserted nucleotides in N nucleotide addition at the DJ-junction lower (mean AS 3.5, FS 3. 2, versus WS 5.2, P = diabetic sibling. Moreover, the pattern of amino acid usage in the CDR3 region was dissimilar at positions 5 and 6, where polar amino acids predominated in both diabetic siblings. In contrast, basic amino acids are preferentially used at position 5 in the clones of the non-diabetic sibling. These data provide information on the general structure of the TCR(BV8S1-BJ1S5) CDR3 region in type 1 diabetes and may indicate differences in the amino and nucleic acid composition of the TCR beta chain CDR3 region between two type 1 diabetic patients and their non-diabetic sibling.

  5. The decommissioning of WWER type nuclear power plants. Final report on an IAEA regional technical co-operation project

    International Nuclear Information System (INIS)

    2000-01-01

    Numerous WWER-440 nuclear power plants are in operation in central and eastern Europe and a small number have already been shut down. In addition to reactors already shut down, many other reactors will reach the end of their design lifetime in a few years and become candidates for decommissioning. It is unfortunate that little consideration was devoted to decommissioning of WWER-440 reactors at the plant design and construction stage, and little emphasis was placed on planning for decommissioning. It is within this context that the IAEA launched a regional technical co-operation project in 1994 with the aim of providing guidance on planning and management of decommissioning for WWERs. The project, which had a duration of four years (1995-1998), included the organization of workshops and scientific visits to countries having WWERs and other countries where active decommissioning projects were under way. Eventually, participants suggested the consolidation of expert guidance and collective opinions into a TECDOC, which was drafted by both designated participants from project recipient countries and invited experts. The TECDOC has the aim of serving as a stimulus for all concerned parties in central and eastern European countries to initiate concrete decommissioning planning, including assessment of existing and required resources for the eventual implementation of decommissioning plans. In addition, the regional technical co-operation project has managed to bring together in this TECDOC a number of good practices that could be useful in WWER-440 decommissioning

  6. Effects of hypoglycaemia on working memory and regional cerebral blood flow in type 1 diabetes: a randomised, crossover trial

    DEFF Research Database (Denmark)

    Gejl, Michael; Gjedde, Albert; Brock, Birgitte

    2018-01-01

    (PET) per session. RESULTS: Working memory was impaired during hypoglycaemia as indicated by a statistically significantly lower mDSST score (estimated treatment difference [ETD] -0.63 [95% CI -1.13, -0.14], p = 0.014) and a statistically significantly longer response time (ETD 2.86 s [7%] [95% CI 0.......67, 5.05], p = 0.013) compared with euglycaemia. During hypoglycaemia, mDSST task performance was associated with increased activity in the frontal lobe regions, superior parietal lobe and thalamus, and decreased activity in the temporal lobe regions (p Working memory activation (mDSST - c......DSST) statistically significantly increased blood flow in the striatum during hypoglycaemia (ETD 0.0374% [95% CI 0.0157, 0.0590], p = 0.002). CONCLUSIONS/INTERPRETATION: During hypoglycaemia (mean PG 2.9 mmol/l), working memory performance was impaired. Altered performance was associated with significantly increased...

  7. Chimeric Sex-Determining Chromosomal Regions and Dysregulation of Cell-Type Identity in a Sterile Zygosaccharomyces Allodiploid Yeast.

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    Melissa Bizzarri

    Full Text Available Allodiploidization is a fundamental yet evolutionarily poorly characterized event, which impacts genome evolution and heredity, controlling organismal development and polyploid cell-types. In this study, we investigated the sex determination system in the allodiploid and sterile ATCC 42981 yeast, a member of the Zygosaccharomyces rouxii species complex, and used it to study how a chimeric mating-type gene repertoire contributes to hybrid reproductive isolation. We found that ATCC 42981 has 7 MAT-like (MTL loci, 3 of which encode α-idiomorph and 4 encode a-idiomorph. Two phylogenetically divergent MAT expression loci were identified on different chromosomes, accounting for a hybrid a/α genotype. Furthermore, extra a-idimorph-encoding loci (termed MTLa copies 1 to 3 were recognized, which shared the same MATa1 ORFs but diverged for MATa2 genes. Each MAT expression locus was linked to a HML silent cassette, while the corresponding HMR loci were located on another chromosome. Two putative parental sex chromosome pairs contributed to this unusual genomic architecture: one came from an as-yet-undescribed taxon, which has the NCYC 3042 strain as a unique representative, while the other did not match any MAT-HML and HMR organizations previously described in Z. rouxii species. This chimeric rearrangement produces two copies of the HO gene, which encode for putatively functional endonucleases essential for mating-type switching. Although both a and α coding sequences, which are required to obtain a functional cell-type a1-α2 regulator, were present in the allodiploid ATCC 42981 genome, the transcriptional circuit, which regulates entry into meiosis in response to meiosis-inducing salt stress, appeared to be turned off. Furthermore, haploid and α-specific genes, such as MATα1 and HO, were observed to be actively transcribed and up-regulated under hypersaline stress. Overall, these evidences demonstrate that ATCC 42981 is unable to repress haploid

  8. N : P Stoichiometry in a Forested Runoff during Storm Events: Comparisons with Regions and Vegetation Types

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    Lanlan Guo

    2012-01-01

    Full Text Available Nitrogen and phosphorus are considered the most important limiting elements in terrestrial and aquatic ecosystems. however, very few studies have focused on which is from forested streams, a bridge between these two systems. To fill this gap, we examined the concentrations of dissolved N and P in storm waters from forested watersheds of five regions in Japan, to characterize nutrient limitation and its potential controlling factors. First, dissolved N and P concentrations and the N : P ratio on forested streams were higher during storm events relative to baseflow conditions. Second, significantly higher dissolved inorganic N concentrations were found in storm waters from evergreen coniferous forest streams than those from deciduous broadleaf forest streams in Aichi, Kochi, Mie, Nagano, and with the exception of Tokyo. Finally, almost all the N : P ratios in the storm water were generally higher than 34, implying that the storm water should be P-limited, especially for Tokyo.

  9. N : P stoichiometry in a forested runoff during storm events: comparisons with regions and vegetation types.

    Science.gov (United States)

    Guo, Lanlan; Chen, Yi; Zhang, Zhao; Fukushima, Takehiko

    2012-01-01

    Nitrogen and phosphorus are considered the most important limiting elements in terrestrial and aquatic ecosystems. however, very few studies have focused on which is from forested streams, a bridge between these two systems. To fill this gap, we examined the concentrations of dissolved N and P in storm waters from forested watersheds of five regions in Japan, to characterize nutrient limitation and its potential controlling factors. First, dissolved N and P concentrations and the N : P ratio on forested streams were higher during storm events relative to baseflow conditions. Second, significantly higher dissolved inorganic N concentrations were found in storm waters from evergreen coniferous forest streams than those from deciduous broadleaf forest streams in Aichi, Kochi, Mie, Nagano, and with the exception of Tokyo. Finally, almost all the N : P ratios in the storm water were generally higher than 34, implying that the storm water should be P-limited, especially for Tokyo.

  10. Temperature sensitivity of drought-induced tree mortality portends increased regional die-off under global-change-type drought

    Science.gov (United States)

    Adams, Henry D.; Guardiola-Claramonte, Maite; Barron-Gafford, Greg A.; Villegas, Juan Camilo; Breshears, David D.; Zou, Chris B.; Troch, Peter A.; Huxman, Travis E.

    2009-01-01

    Large-scale biogeographical shifts in vegetation are predicted in response to the altered precipitation and temperature regimes associated with global climate change. Vegetation shifts have profound ecological impacts and are an important climate-ecosystem feedback through their alteration of carbon, water, and energy exchanges of the land surface. Of particular concern is the potential for warmer temperatures to compound the effects of increasingly severe droughts by triggering widespread vegetation shifts via woody plant mortality. The sensitivity of tree mortality to temperature is dependent on which of 2 non-mutually-exclusive mechanisms predominates—temperature-sensitive carbon starvation in response to a period of protracted water stress or temperature-insensitive sudden hydraulic failure under extreme water stress (cavitation). Here we show that experimentally induced warmer temperatures (≈4 °C) shortened the time to drought-induced mortality in Pinus edulis (piñon shortened pine) trees by nearly a third, with temperature-dependent differences in cumulative respiration costs implicating carbon starvation as the primary mechanism of mortality. Extrapolating this temperature effect to the historic frequency of water deficit in the southwestern United States predicts a 5-fold increase in the frequency of regional-scale tree die-off events for this species due to temperature alone. Projected increases in drought frequency due to changes in precipitation and increases in stress from biotic agents (e.g., bark beetles) would further exacerbate mortality. Our results demonstrate the mechanism by which warmer temperatures have exacerbated recent regional die-off events and background mortality rates. Because of pervasive projected increases in temperature, our results portend widespread increases in the extent and frequency of vegetation die-off. PMID:19365070

  11. TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region.

    Science.gov (United States)

    Rossi, Valeria; Beffagna, Giorgia; Rampazzo, Alessandra; Bauce, Barbara; Danieli, Gian Antonio

    2004-06-23

    Isthmins represent a novel family of vertebrate secreted proteins containing one copy of the thrombospondin type 1 repeat (TSR), which in mammals is shared by several proteins with diverse biological functions, including cell adhesion, angiogenesis, and patterning of developing nervous system. We have determined the genomic organization of human TAIL1 (thrombospondin and AMOP containing isthmin-like 1), a novel isthmin-like gene encoding a protein that contains a TSR and a C-terminal AMOP domain (adhesion-associated domain in MUC4 and other proteins), characteristic of extracellular proteins involved in adhesion processes. TAIL1 gene encompasses more than 24.4 kb. Analysis of the DNA sequence surrounding the putative transcriptional start region revealed a TATA-less promoter located in a CpG island. Several consensus binding sites for the transcription factors Sp1 and MZF-1 were identified in this promoter region. In humans, TAIL1 gene is located on chromosome 14q24.3 within ARVD1 (arrhythmogenic right ventricular dysplasia/cardiomyopathy, type 1) critical region; preliminary evidence suggests that it is expressed in several tissues, showing multiple alternative splicing.

  12. [Association of single nucleotide polymorphisms of susceptibility genes of type 2 diabetes mellitus with liability to gout among ethnic Han Chinese males from coastal region of Shandong].

    Science.gov (United States)

    Han, Lin; Xin, Ruosai; Sun, Jian; Hou, Feng; Li, Changgui; Hu, Xinlin; Liu, Zhen; Wang, Yao; Li, Xinde; Ren, Wei; Wang, Xuefeng; Jia, Zhaotong

    2015-10-01

    OBJECTIVE To assess the association of single nucleotide polymorphisms (SNPs) of susceptibility genes of type 2 diabetes mellitus (T2DM) with liability to gout among ethnic Han Chinese males from coastal region of Shandong province. METHODS Seven SNPs within the susceptibility genes of T2DM, including rs10773971(G/C) and rs4766398(G/C) of WNT5B gene, rs10225163(G/C) of JAZF1 gene, rs2069590(T/A) of BDKRB2 gene, rs5745709(G/A) of HGF gene, rs1991914(C/A) of OTOP1 gene and rs2236479(G/A) of COL18A1 gene, were typed with a custom-made Illumina GoldenGate Genotyping assay in 480 male patients with gout and 480 male controls. Potential association was assessed with the chi-square test. RESULTS No significant difference was detected for the 7 selected SNPs in terms of genotypic and allelic frequencies (P > 0.05). When age and body mass index (BMI) were adjusted, the 7 genetic variants still showed no significant association with gout. CONCLUSION The genotypes of the 7 selected SNPs are not associated with gout in ethnic Han Chinese male patients from the coastal region of Shandong province. However, the results need to be replicated in larger sets of patients collected from other regions and populations.

  13. Developing Models to Predict the Number of Fire Hotspots from an Accumulated Fuel Dryness Index by Vegetation Type and Region in Mexico

    Directory of Open Access Journals (Sweden)

    D. J. Vega-Nieva

    2018-04-01

    Full Text Available Understanding the linkage between accumulated fuel dryness and temporal fire occurrence risk is key for improving decision-making in forest fire management, especially under growing conditions of vegetation stress associated with climate change. This study addresses the development of models to predict the number of 10-day observed Moderate-Resolution Imaging Spectroradiometer (MODIS active fire hotspots—expressed as a Fire Hotspot Density index (FHD—from an Accumulated Fuel Dryness Index (AcFDI, for 17 main vegetation types and regions in Mexico, for the period 2011–2015. The AcFDI was calculated by applying vegetation-specific thresholds for fire occurrence to a satellite-based fuel dryness index (FDI, which was developed after the structure of the Fire Potential Index (FPI. Linear and non-linear models were tested for the prediction of FHD from FDI and AcFDI. Non-linear quantile regression models gave the best results for predicting FHD using AcFDI, together with auto-regression from previously observed hotspot density values. The predictions of 10-day observed FHD values were reasonably good with R2 values of 0.5 to 0.7 suggesting the potential to be used as an operational tool for predicting the expected number of fire hotspots by vegetation type and region in Mexico. The presented modeling strategy could be replicated for any fire danger index in any region, based on information from MODIS or other remote sensors.

  14. Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix

    DEFF Research Database (Denmark)

    Heim, Joel B; Squirewell, Edwin J; Neu, Ancilla

    2017-01-01

    Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase involved in development and human disease, including cancer. It is currently thought that the four-point one, ezrin, radixin, moesin (FERM)-kinase domain linker, which contains autophosphorylation site tyrosine (Y) 397, is not required...... for in vivo FAK function until late midgestation. Here, we directly tested this hypothesis by generating mice with FAK Y397-to-phenylalanine (F) mutations in the germline. We found that Y397F embryos exhibited reduced mesodermal fibronectin (FN) and osteopontin expression and died during mesoderm development...... and other FN-type matrix in both mouse embryonic fibroblasts and human melanoma. Our data support a model in which FAK Y397 autophosphorylation is required for FAK function in vivo and is positively regulated by MYO1E....

  15. Complex Regional Pain Syndrome (CRPS type-1) in an Adolescent Following Extravasation of Dextrose Containing Fluid-an Underdiagnosed Case.

    Science.gov (United States)

    Subedi, Asish; Bhattarai, Balkrishna; Biswas, Binay K; Khatiwada, Sindhu

    2011-06-01

    Due to its complex pathophysiology and wide spectrum of clinical manifestations, the diagnosis of CRPS is often missed in the early stage by primary care physicians. After being treated by a primary care physician for 5 months for chronic cellulitis, a 16-year-old girl was referred to our hospital with features of type-1 CRPS of the right upper extremity. Inability to diagnose early caused prolonged suffering to the girl with all the consequence of CRPS. The patient responded well with marked functional recovery from multimodal therapy. Ability to distinguish CRPS from other pain conditions, referral for specialty care at the appropriate time and full awareness of this condition and its clinical features among various healthcare professionals are essential in reducing patient suffering and stopping its progression towards difficult-to-treat situations.

  16. Three Paradigms of Social Assistance

    Directory of Open Access Journals (Sweden)

    Pierre-Marc Daigneault

    2014-11-01

    Full Text Available “Ideas,” which are defined as the normative and cognitive beliefs of actors, are fundamental to a full understanding of the welfare state and, in particular, of social assistance. However, policy ideas have been neglected in most typologies of social assistance regimes. Based on a selective review of the literature, this article proposes a brief but systematic analysis of policy paradigms in the field of social assistance. Three ideal types that emphasize the ideational dimension of social assistance are analyzed, namely, the entitlement, workfare, and activation paradigms. The value of the typology lies in its utility for characterizing the ideational orientation of social assistance regimes. Specifically, the typology provides a yardstick for measuring the ideas of policy actors with respect to social assistance and can facilitate the conduct of case studies, comparative research, and causal analyses on this policy sector.

  17. Lack of association between KCNJ11 (rs5219 and ABCC8 (rs757110 polymorphisms and sulphonylurea treatment response in type 2 diabetes patients in Novosibirsk region

    Directory of Open Access Journals (Sweden)

    Irina Arkad'evna Bondar

    2015-03-01

    Full Text Available Aim. Sulfonylureas (SU are widely used in everyday clinical practice in treatment of patients with type 2 diabetes mellitus (T2DM. There is a considerable variability in SU effects, which may be caused by psychological, social, biological and genetic factors. The aim of the study was to investigate the association between rs5219 KCNJ11 gene and rs757110 ABCC8 gene polymorphism and long-term response to SU-drugs of second and third generation in the Novosibirsk region. Materials and Methods. 326 patients with type 2 diabetes in the Novosibirsk region were examined. Patients were divided into 2 groups, depending on HbA1c level. The first group included patients with target HbA1c levels on SU monotherapy. The second group included patients who did not reach target HbA1c levels on the highest dose of SU. Genotyping of KCNJ11 (rs5219 and ABCC8 (rs757110 was performed by TaqMan real-time PCR (ICBFM SB RAS, Novosibirsk, Russia. Results. Patients with type 2 diabetes with a good response to SU-therapy compared to the group of patients with a poor response to SU-therapy were older (65.8?9.1 years vs. 61.6?7.9 years, p

  18. Characterization of Clostridium difficile Strains in British Columbia, Canada: A Shift from NAP1 Majority (2008 to Novel Strain Types (2013 in One Region

    Directory of Open Access Journals (Sweden)

    Agatha N. Jassem

    2016-01-01

    Full Text Available Background. Clostridium difficile is a major cause of gastrointestinal illness. Epidemic NAP1 strains contain toxins A and B, a deletion in repressor tcdC, and a binary toxin. Objectives. To determine the molecular epidemiology of C. difficile in British Columbia and compare between two time points in one region. Methods. C. difficile isolates from hospital and community laboratories (2008 and one Island Health hospital laboratory (2013 were characterized by pulsed-field gel electrophoresis, PCR-ribotyping, toxin possession, tcdC genotype, and antimicrobial susceptibility. Results. In 2008, 42.7% of isolates had NAP1 designation. Hospital-collected isolates were associated with older patients and more NAP1 types. Unlike other isolates, most NAP1 isolates possessed binary toxin and a 19 bp loss in tcdC. All isolates were susceptible to metronidazole and vancomycin. A 2013 follow-up revealed a 28.9% decrease in NAP1 isolates and 20.0% increase in isolates without NAP designation in one region. Then, community-associated cases were seen in younger patients, while NAP types were evenly distributed. Isolates without NAP designation did not cluster with a PFGE pattern or ribotype. Conclusions. Evaluation of C. difficile infections within British Columbia revealed demographic associations, epidemiological shifts, and characteristics of strain types. Continuous surveillance of C. difficile will enable detection of emerging strains.

  19. Assisted Living

    Science.gov (United States)

    ... a resident's needs depends as much on the philosophy and services of the assisted living facility as it does on the quality of care. The Administration on Aging, a part of the U.S. Department of Health and Human Services (HHS), offers these suggestions to help you ...

  20. Enhanced pain and autonomic responses to ambiguous visual stimuli in chronic Complex Regional Pain Syndrome (CRPS) type I.

    Science.gov (United States)

    Cohen, H E; Hall, J; Harris, N; McCabe, C S; Blake, D R; Jänig, W

    2012-02-01

    Cortical reorganisation of sensory, motor and autonomic systems can lead to dysfunctional central integrative control. This may contribute to signs and symptoms of Complex Regional Pain Syndrome (CRPS), including pain. It has been hypothesised that central neuroplastic changes may cause afferent sensory feedback conflicts and produce pain. We investigated autonomic responses produced by ambiguous visual stimuli (AVS) in CRPS, and their relationship to pain. Thirty CRPS patients with upper limb involvement and 30 age and sex matched healthy controls had sympathetic autonomic function assessed using laser Doppler flowmetry of the finger pulp at baseline and while viewing a control figure or AVS. Compared to controls, there were diminished vasoconstrictor responses and a significant difference in the ratio of response between affected and unaffected limbs (symmetry ratio) to a deep breath and viewing AVS. While viewing visual stimuli, 33.5% of patients had asymmetric vasomotor responses and all healthy controls had a homologous symmetric pattern of response. Nineteen (61%) CRPS patients had enhanced pain within seconds of viewing the AVS. All the asymmetric vasomotor responses were in this group, and were not predictable from baseline autonomic function. Ten patients had accompanying dystonic reactions in their affected limb: 50% were in the asymmetric sub-group. In conclusion, there is a group of CRPS patients that demonstrate abnormal pain networks interacting with central somatomotor and autonomic integrational pathways. © 2011 European Federation of International Association for the Study of Pain Chapters.

  1. Ribosomal subunit protein typing using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) for the identification and discrimination of Aspergillus species.

    Science.gov (United States)

    Nakamura, Sayaka; Sato, Hiroaki; Tanaka, Reiko; Kusuya, Yoko; Takahashi, Hiroki; Yaguchi, Takashi

    2017-04-26

    Accurate identification of Aspergillus species is a very important subject. Mass spectral fingerprinting using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) is generally employed for the rapid identification of fungal isolates. However, the results are based on simple mass spectral pattern-matching, with no peak assignment and no taxonomic input. We propose here a ribosomal subunit protein (RSP) typing technique using MALDI-TOF MS for the identification and discrimination of Aspergillus species. The results are concluded to be phylogenetic in that they reflect the molecular evolution of housekeeping RSPs. The amino acid sequences of RSPs of genome-sequenced strains of Aspergillus species were first verified and compared to compile a reliable biomarker list for the identification of Aspergillus species. In this process, we revealed that many amino acid sequences of RSPs (about 10-60%, depending on strain) registered in the public protein databases needed to be corrected or newly added. The verified RSPs were allocated to RSP types based on their mass. Peak assignments of RSPs of each sample strain as observed by MALDI-TOF MS were then performed to set RSP type profiles, which were then further processed by means of cluster analysis. The resulting dendrogram based on RSP types showed a relatively good concordance with the tree based on β-tubulin gene sequences. RSP typing was able to further discriminate the strains belonging to Aspergillus section Fumigati. The RSP typing method could be applied to identify Aspergillus species, even for species within section Fumigati. The discrimination power of RSP typing appears to be comparable to conventional β-tubulin gene analysis. This method would therefore be suitable for species identification and discrimination at the strain to species level. Because RSP typing can characterize the strains within section Fumigati, this method has potential as a powerful and reliable tool in

  2. Dengue type 4 in Rio de Janeiro, Brazil: case characterization following its introduction in an endemic region.

    Science.gov (United States)

    Heringer, Manoela; Souza, Thiara Manuele A; Lima, Monique da Rocha Q; Nunes, Priscila Conrado G; Faria, Nieli Rodrigues da C; de Bruycker-Nogueira, Fernanda; Chouin-Carneiro, Thaís; Nogueira, Rita Maria R; Dos Santos, Flavia Barreto

    2017-06-09

    Due to the populations' susceptibility, DENV-4 introduction in 2010 led to the occurrence of explosive epidemics in the following years in Brazil. In 2011, DENV-4 was identified in Rio de Janeiro (RJ) and it was prevalent in 2012 and 2013. Here, we aimed to characterize clinical, epidemiological and laboratorial aspects of DENV-4 cases after this serotype introduction in an endemic scenario. Dengue suspected cases (n = 3727) were received and analyzed from January 2011 to December 2013, during outbreaks occurred in RJ, Brazil. Samples were submitted to virological, serological and molecular methods for case confirmation. DENV-4 cases (n = 705) were characterized according to the type of infection, disease severity and, viremia levels and NS1 antigenemia were accessed. Representative strains were partial sequenced for genotyping. DENV-4 was identified in 44.2% (705/1593) of dengue positive cases, virus isolated in 48.7% of the cases. Anti-DENV IgM was detected in 39.4% of the cases, however an increased detection was observed in cases with ≥4 days of symptoms (57.0%). NS1 antigen was identified in 41.5% of DENV-4 cases however, after immune complexes dissociation, the detection significantly increased (87.6%). Females were more affected than males, so did children aged 11-15 years old. Primary cases were more frequently observed than secondary ones and most of them were classified as dengue. No differences on NS1 antigenemia and viraemia within the groups were observed. Despite the higher frequency of severe disease on individuals >65 years old, no differences were observed among the groups and type of infection. However, DENV-4 fatal cases were more frequent on secondary infections (57.1%). DENV-4 Genotype II was identified with a probable origin from Venezuela and Colombia. It has been shown that laboratorial diagnosis is still a reliable tool for the disease surveillance, detecting and confirming emerging epidemics. Despite the occurrence of secondary

  3. Incidence of Type 1 Diabetes among Children and Adolescents in Italy between 2009 and 2013: The Role of a Regional Childhood Diabetes Registry

    Directory of Open Access Journals (Sweden)

    F. Fortunato

    2016-01-01

    Full Text Available Background. Surveillance represents a key strategy to control type 1 diabetes mellitus (T1DM. In Italy, national data are missing. This study aimed at evaluating the incidence of T1DM in subjects <18 year olds in Apulia (a large southeastern region, about 4,000,000 inhabitants and assessing the sensitivity of the regional Registry of Childhood-Onset Diabetes (RCOD in the 2009–2013 period. Methods. We performed a retrospective study matching records from regional Hospital Discharge Registry (HDR, User Fee Exempt Registry (UFER, and Drugs Prescription Registry (DPR and calculated T1DM incidence; completeness of each data source was also estimated. In order to assess the RCOD sensitivity we compared cases from the registry to those extracted from HDR-UFER-DPR matching. Results. During 2009–2013, a total of 917 cases (about 184/year in at least one of the three sources and an annual incidence of 25.2 per 100,000 were recorded, lower in infant, increasing with age and peaked in 5- to 9-year-olds. The completeness of DPR was 78.7%, higher than that of UFER (64.3% and of HDR (59.6%. The RCOD’s sensitivity was 39.05% (360/922; 95% CI: 34.01%–44.09%. Conclusions. Apulia appeared as a high-incidence region. A full, active involvement of physicians working in paediatric diabetes clinics would be desirable to improve the RCOD performance.

  4. An ArcGIS-based tool for the relational data management assistance of Natura 2000 habitat units in the Walloon Region, Belgium

    Directory of Open Access Journals (Sweden)

    Barbier Y.

    2009-01-01

    Full Text Available The Natura 2000 network designation stems from two important European conservation directives (79/409/EEC and 92/43/EEC. Each EU member state was instructed to draw up a national list of Natura 2000 conservation sites. This has largely been done. The next step is to specify what action has to be taken and what needs to be controlled in these sites by means of specific designation acts. In the Walloon Region in Belgium, the designation acts have to include a full description of the site and the habitats composing it. For this purpose, field biologists have been making a detailed inventory of all Natura 2000 sites. Land use and habitats are mapped into a Geographic Information System (ArcGIS and a full description of them (including information needed to describe conservation states is stored in a relational database (Access. The main problem is ensuring data integrity between the cartographic and database systems, which are completely separate. The technical solution that has been developed is an original set of tools integrated into the ArcGIS interface. These tools offer a variety of functions that enable users to create dynamic links between ArcGIS and Access. A tool will also carry out batch synchronization between the two systems.

  5. Relationship between air mass type and emergency department visits for migraine headache across the Triangle region of North Carolina

    Science.gov (United States)

    Elcik, Christopher; Fuhrmann, Christopher M.; Mercer, Andrew E.; Davis, Robert E.

    2017-12-01

    An estimated 240 million people worldwide suffer from migraines. Because migraines are often debilitating, understanding the mechanisms that trigger them is crucial for effective prevention and treatment. Synoptic air mass types and emergency department (ED) visits for migraine headaches were examined over a 7-year period within a major metropolitan area of North Carolina to identify potential relationships between large-scale meteorological conditions and the incidence of migraine headaches. Barometric pressure changes associated with transitional air masses, or changing weather patterns, were also analyzed for potential relationships. Bootstrapping analysis revealed that tropical air masses (moist and dry) resulted in the greatest number of migraine ED visits over the study period, whereas polar air masses led to fewer. Moist polar air masses in particular were found to correspond with the fewest number of migraine ED visits. On transitional air mass days, the number of migraine ED visits fell between those of tropical air mass days and polar air mass days. Transitional days characterized by pressure increases exhibited a greater number of migraine ED visits than days characterized by pressure decreases. However, no relationship was found between migraine ED visits and the magnitude of barometric pressure changes associated with transitional air masses.

  6. Variation in carbon stocks on different slope aspects in seven major forest types of temperate region of Garhwal Himalaya, India.

    Science.gov (United States)

    Sharma, C M; Gairola, Sumeet; Baduni, N P; Ghildiyal, S K; Suyal, Sarvesh

    2011-09-01

    The present study was undertaken in seven major forest types of temperate zone (1500 m a.s.l. to 3100 m a.s.l.) of Garhwal Himalaya to understand the effect of slope aspects on carbon (C) density and make recommendations for forest management based on priorities for C conservation/sequestration. We assessed soil organic carbon (SOC) density, tree density, biomass and soil organic carbon (SOC) on four aspects, viz. north/east (NE), north/west (NW), south-east (SE) and south-west (SW), in forest stands dominated by Abies pindrow, Cedrus deodara, Pinus roxburghii, Cupressus torulosa, Quercus floribunda, Quercus semecarpifolia and Quercus leucotrichophora. TCD ranged between 77.3 CMg ha⁻¹ on SE aspect (Quercus leucotrichophora forest) and 291.6 CMg ha⁻¹ on NE aspect (moist Cedrus deodara forest). SOC varied between 40.3 CMg ha⁻¹ on SW aspect (Himalayan Pinus roxburghii forest) and 177.5 CMg ha⁻¹ on NE aspect (moist Cedrus deodara forest). Total C density (SOC+TCD) ranged between 118.1 CMg ha⁻¹ on SW aspect (Himalayan Pinus roxburghii forest) and 469.1 CMg ha⁻¹ on NE aspect (moist Cedrus deodara forest). SOC and TCD were significantly higher on northern aspects as compared with southern aspects. It is recommended that for C sequestration, the plantation silviculture be exercised on northern aspects, and for C conservation purposes, mature forest stands growing on northern aspects be given priority.

  7. Photo-assisted Kelvin probe force microscopy investigation of three dimensional GaN structures with various crystal facets, doping types, and wavelengths of illumination

    Science.gov (United States)

    Ali Deeb, Manal; Ledig, Johannes; Wei, Jiandong; Wang, Xue; Wehmann, Hergo-Heinrich; Waag, Andreas

    2017-08-01

    Three dimensional GaN structures with different crystal facets and doping types have been investigated employing the surface photo-voltage (SPV) method to monitor illumination-induced surface charge behavior using Kelvin probe force microscopy. Various photon energies near and below the GaN bandgap were used to modify the generation of electron-hole pairs and their motion under the influence of the electric field near the GaN surface. Fast and slow processes for Ga-polar c-planes on both Si-doped n-type as well as Mg-doped p-type GaN truncated pyramid micro-structures were found and their origin is discussed. The immediate positive (for n-type) and negative (for p-type) SPV response dominates at band-to-band and near-bandgap excitation, while only the slow process is present at sub-bandgap excitation. The SPV behavior for the semi-polar facets of the p-type GaN truncated pyramids has a similar characteristic to that on its c-plane, which indicates that it has a comparable band bending and no strong influence of the polarity-induced charges is detectable. The SPV behavior of the non-polar m-facets of the Si-doped n-type part of a transferred GaN column is similar to that of a clean c-plane GaN surface during illumination. However, the SPV is smaller in magnitude, which is attributed to intrinsic surface states of m-plane surfaces and their influence on the band bending. The SPV behavior of the non-polar m-facet of the slightly Mg-doped part of this GaN column is found to behave differently. Compared to c- and r-facets of p-type surfaces of GaN-light-emitting diode micro-structures, the m-plane is more chemically stable.

  8. Assistance Focus: Africa

    Energy Technology Data Exchange (ETDEWEB)

    2017-03-29

    The Clean Energy Solutions Center, an initiative of the Clean Energy Ministerial, helps countries throughout the world create policies and programs that advance the deployment of clean energy technologies. Through the Solutions Center's no-cost 'Ask an Expert' service, a team of international experts has delivered assistance to countries in all regions of the world. High-impact examples from Africa are featured here.

  9. Complete recovery from intractable complex regional pain syndrome, CRPS-type I, following anesthetic ketamine and midazolam.

    Science.gov (United States)

    Kiefer, Ralph-Thomas; Rohr, Peter; Ploppa, Annette; Altemeyer, Karl-Heinz; Schwartzman, Robert Jay

    2007-06-01

    To describe the treatment of an intractable complex regional pain syndrome I (CRPS-I) patient with anesthetic doses of ketamine supplemented with midazolam. A patient presented with a rapidly progressing contiguous spread of CRPS from a severe ligamentous wrist injury. Standard pharmacological and interventional therapy successively failed to halt the spread of CRPS from the wrist to the entire right arm. Her pain was unmanageable with all standard therapy. As a last treatment option, the patient was transferred to the intensive care unit and treated on a compassionate care basis with anesthetic doses of ketamine in gradually increasing (3-5 mg/kg/h) doses in conjunction with midazolam over a period of 5 days. On the second day of the ketamine and midazolam infusion, edema, and discoloration began to resolve and increased spontaneous movement was noted. On day 6, symptoms completely resolved and infusions were tapered. The patient emerged from anesthesia completely free of pain and associated CRPS signs and symptoms. The patient has maintained this complete remission from CRPS for 8 years now. In a patient with severe spreading and refractory CRPS, a complete and long-term remission from CRPS has been obtained utilizing ketamine and midazolam in anesthetic doses. This intensive care procedure has very serious risks but no severe complications occurred. The psychiatric side effects of ketamine were successfully managed with the concomitant use of midazolam and resolved within 1 month of treatment. This case report illustrates the effectiveness and safety of high-dose ketamine in a patient with generalized, refractory CRPS.

  10. Role of NFkappaB in an animal model of complex regional pain syndrome-type I (CRPS-I).

    Science.gov (United States)

    de Mos, Marissa; Laferrière, André; Millecamps, Magali; Pilkington, Mercedes; Sturkenboom, Miriam C J M; Huygen, Frank J P M; Coderre, Terence J

    2009-11-01

    NFkappaB is involved in several pathogenic mechanisms that are believed to underlie the complex regional pain syndrome (CRPS), including ischemia, inflammation and sensitization. Chronic postischemia pain (CPIP) has been developed as an animal model that mimics the symptoms of CRPS-I. The possible involvement of NFkappaB in CRPS-I was studied using CPIP rats. Under sodium pentobarbital anesthesia, a tourniquet was placed around the rat left ankle joint, producing 3 hours of ischemia, followed by rapid reperfusion (IR injury). NFkappaB was measured in nuclear extracts of muscle and spinal cord tissue using ELISA. Moreover, the anti-allodynic (mechanical and cold) effect was tested for systemic, intrathecal, or intraplantar treatment with the NFkappaB inhibitor pyrrolidine dithiocarbamate (PDTC). At 2 and 48 hours after IR injury, NFkappaB was elevated in muscle and spinal cord of CPIP rats compared to shams. At 7 days, NFkappaB levels were normalized in muscle, but still elevated in spinal cord tissue. Systemic PDTC treatment relieved mechanical and cold allodynia in a dose-dependent manner, lasting for at least 3 hours. Intrathecal-but not intraplantar-administration also relieved mechanical allodynia. The results suggest that muscle and spinal NFkappaB plays a role in the pathogenesis of CPIP and potentially of human CRPS. Using the CPIP model, we demonstrate that NFkappaB is involved in the development of allodynia after a physical injury (ischemia and reperfusion) without direct nerve trauma. Since CPIP animals exhibit many features of human CRPS-I, this observation indicates a potential role for NFkappaB in human CRPS.

  11. [Supply and demand of medical specialists in the health facilities of the Ministry of Health: national, regional and by type of specialty gaps].

    Science.gov (United States)

    Zevallos, Leslie; Pastor, Reyna; Moscoso, Betsy

    2011-06-01

    To characterize the supply, demand and the gap of medical specialists in facilities of the Ministry of Health of Peru (MINSA) at the national, regional and specialty type levels. Observational, descriptive study through which we calculated the supply of medical specialists using secondary sources of MINSA. The analysis of the demand for medical specialists was based on two methodologies: the need for specialists according to the guidelines of classification of the health facilities and according to the epidemiological and demographic profile. The arithmetic difference between the estimated demand and the supply was the procedure used to calculate the gap of medical specialists. The Ministry of Health has a total supply at the national level of 6,074 medical specialists of which 61.5% belong to the clinical specialties, 33.2% to the surgical specialties, 4.9% specialities related to aid to diagnosis and treatment and 0.4% to public health specialties. According to the categorization guideline there is a total demand of 11,176 medical specialists and according to the epidemiological and demographic profile of 11,738. The national estimated gaps found are similar in both methods, although they differ widely across regions and by type of specialty. At the regional level, the gaps are greater in Loreto, Piura, Puno and Madre de Dios when estimating the defficit in relation to the supply. Regarding the speciality, the gap is greater in the four basic specialties: gynecology and obstetrics, pediatrics, internal medicine and general surgery. There is a waid gap between supply and demand of medical specialists at the national and regional levels, as a whole representing approximately 45% of the current offer, regardless of the estimation method.

  12. Consortium for Osteogenesis Imperfecta Mutations in the Helical Domain of Type I Collagen: Regions Rich in Lethal Mutations Align With Collagen Binding Sites for Integrins and Proteoglycans

    Science.gov (United States)

    Marini, Joan C.; Forlino, Antonella; Cabral, Wayne A.; Barnes, Aileen M.; San Antonio, James D.; Milgrom, Sarah; Hyland, James C.; Körkkö, Jarmo; Prockop, Darwin J.; De Paepe, Anne; Coucke, Paul; Symoens, Sofie; Glorieux, Francis H.; Roughley, Peter J.; Lund, Alan M.; Kuurila-Svahn, Kaija; Hartikka, Heini; Cohn, Daniel H.; Krakow, Deborah; Mottes, Monica; Schwarze, Ulrike; Chen, Diana; Yang, Kathleen; Kuslich, Christine; Troendle, James; Dalgleish, Raymond; Byers, Peter H.

    2014-01-01

    Osteogenesis imperfecta (OI) is a generalized disorder of connective tissue characterized by fragile bones and easy susceptibility to fracture. Most cases of OI are caused by mutations in type I collagen. We have identified and assembled structural mutations in type I collagen genes (COL1A1 and COL1A2, encoding the proα1(I) and proα2(I) chains, respectively) that result in OI. Quantitative defects causing type I OI were not included. Of these 832 independent mutations, 682 result in substitution for glycine residues in the triple helical domain of the encoded protein and 150 alter splice sites. Distinct genotype–phenotype relationships emerge for each chain. One-third of the mutations that result in glycine substitutions in α1(I) are lethal, especially when the substituting residues are charged or have a branched side chain. Substitutions in the first 200 residues are nonlethal and have variable outcome thereafter, unrelated to folding or helix stability domains. Two exclusively lethal regions (helix positions 691–823 and 910–964) align with major ligand binding regions (MLBRs), suggesting crucial interactions of collagen monomers or fibrils with integrins, matrix metalloproteinases (MMPs), fibronectin, and cartilage oligomeric matrix protein (COMP). Mutations in COL1A2 are predominantly nonlethal (80%). Lethal substitutions are located in eight regularly spaced clusters along the chain, supporting a regional model. The lethal regions align with proteoglycan binding sites along the fibril, suggesting a role in fibril–matrix interactions. Recurrences at the same site in α2(I) are generally concordant for outcome, unlike α1(I). Splice site mutations comprise 20% of helical mutations identified in OI patients, and may lead to exon skipping, intron inclusion, or the activation of cryptic splice sites. Splice site mutations in COL1A1 are rarely lethal; they often lead to frameshifts and the mild type I phenotype. In α2(I), lethal exon skipping events are

  13. A Regional Multi-scale 3D Geological Model of the Eastern Sub-Athabasca Basement, Canada: Implications for Vectoring towards Unconformity-type Uranium Deposits

    International Nuclear Information System (INIS)

    Annesley, Irvine R.; Reilkoff, Brian; Takacs, Erno; Hajnal, Zoltan; Pandit, Bhaskar

    2014-01-01

    Summary and Conclusions • The GOCAD common earth environment allows integration of multiple geological, geophysical, geochemical, and petrophysical data sets from surface to depth. • We are able to manipulate and visualize the regional to district scale architecture of the Wollaston fold-and-thrust belt, especially with the aid of high-resolution seismic profiles. • High-resolution seismic and diamond drilling constrain the 3rd dimension. • The GOCAD model can be used in other modelling applications. • Our research is bringing new insight(s) to the role of the basement in the genesis of unconformity-type U deposits.

  14. A special type of neutron-proton pairing interaction and the moments of inertia of some deformed even-even nuclei in the rare earth region

    International Nuclear Information System (INIS)

    Meftunoglu, E.; Gerceklioglu, M.; Erbil, H.H.; Kuliev, A.A.

    1998-01-01

    In this work, the effect of a special type of neutron-proton pairing interaction on the moments of inertia of some deformed nuclei in the rare earth region is investigated. First, making a perturbative approximation, we assume that the form of the equations of the BCS theory and usual Bogolyubov transformations are unchanged. Second, we use a phenomenological method for the strength of this neutron-proton pairing interaction introducing a parameter. Calculations show that this interaction is important for the ground-state moments of inertia and that it could be effectual in other nuclear phenomena. (author)

  15. Rapid identification and typing of Yersinia pestis and other Yersinia species by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.

    Science.gov (United States)

    Ayyadurai, Saravanan; Flaudrops, Christophe; Raoult, Didier; Drancourt, Michel

    2010-11-12

    Accurate identification is necessary to discriminate harmless environmental Yersinia species from the food-borne pathogens Yersinia enterocolitica and Yersinia pseudotuberculosis and from the group A bioterrorism plague agent Yersinia pestis. In order to circumvent the limitations of current phenotypic and PCR-based identification methods, we aimed to assess the usefulness of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) protein profiling for accurate and rapid identification of Yersinia species. As a first step, we built a database of 39 different Yersinia strains representing 12 different Yersinia species, including 13 Y. pestis isolates representative of the Antiqua, Medievalis and Orientalis biotypes. The organisms were deposited on the MALDI-TOF plate after appropriate ethanol-based inactivation, and a protein profile was obtained within 6 minutes for each of the Yersinia species. When compared with a 3,025-profile database, every Yersinia species yielded a unique protein profile and was unambiguously identified. In the second step of analysis, environmental and clinical isolates of Y. pestis (n = 2) and Y. enterocolitica (n = 11) were compared to the database and correctly identified. In particular, Y. pestis was unambiguously identified at the species level, and MALDI-TOF was able to successfully differentiate the three biotypes. These data indicate that MALDI-TOF can be used as a rapid and accurate first-line method for the identification of Yersinia isolates.

  16. Effects of solid-medium type on routine identification of bacterial isolates by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry.

    Science.gov (United States)

    Anderson, Neil W; Buchan, Blake W; Riebe, Katherine M; Parsons, Lauren N; Gnacinski, Stacy; Ledeboer, Nathan A

    2012-03-01

    Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) is a rapid method for the identification of bacteria. Factors that may alter protein profiles, including growth conditions and presence of exogenous substances, could hinder identification. Bacterial isolates identified by conventional methods were grown on various media and identified using the MALDI Biotyper (Bruker Daltonics, Billerica, MA) using a direct smear method and an acid extraction method. Specimens included 23 Pseudomonas isolates grown on blood agar, Pseudocel (CET), and MacConkey agar (MAC); 20 Staphylococcus isolates grown on blood agar, colistin-nalidixic acid agar (CNA), and mannitol salt agar (MSA); and 25 enteric isolates grown on blood agar, xylose lysine deoxycholate agar (XLD), Hektoen enteric agar (HE), salmonella-shigella agar (SS), and MAC. For Pseudomonas spp., the identification rate to genus using the direct method was 83% from blood, 78% from MAC, and 94% from CET. For Staphylococcus isolates, the identification rate to genus using the direct method was 95% from blood, 75% from CNA, and 95% from MSA. For enteric isolates, the identification rate to genus using the direct method was 100% from blood, 100% from MAC, 100% from XLD, 92% from HE, and 87% from SS. Extraction enhanced identification rates. The direct method of MALDI-TOF analysis of bacteria from selective and differential media yields identifications of varied confidence. Notably, Staphylococci spp. from CNA exhibit low identification rates. Extraction enhances identification rates and is recommended for colonies from this medium.

  17. A novel typing method for Listeria monocytogenes using high-resolution melting analysis (HRMA) of tandem repeat regions.

    Science.gov (United States)

    Ohshima, Chihiro; Takahashi, Hajime; Iwakawa, Ai; Kuda, Takashi; Kimura, Bon

    2017-07-17

    Listeria monocytogenes, which is responsible for causing food poisoning known as listeriosis, infects humans and animals. Widely distributed in the environment, this bacterium is known to contaminate food products after being transmitted to factories via raw materials. To minimize the contamination of products by food pathogens, it is critical to identify and eliminate factory entry routes and pathways for the causative bacteria. High resolution melting analysis (HRMA) is a method that takes advantage of differences in DNA sequences and PCR product lengths that are reflected by the disassociation temperature. Through our research, we have developed a multiple locus variable-number tandem repeat analysis (MLVA) using HRMA as a simple and rapid method to differentiate L. monocytogenes isolates. While evaluating our developed method, the ability of MLVA-HRMA, MLVA using capillary electrophoresis, and multilocus sequence typing (MLST) was compared for their ability to discriminate between strains. The MLVA-HRMA method displayed greater discriminatory ability than MLST and MLVA using capillary electrophoresis, suggesting that the variation in the number of repeat units, along with mutations within the DNA sequence, was accurately reflected by the melting curve of HRMA. Rather than relying on DNA sequence analysis or high-resolution electrophoresis, the MLVA-HRMA method employs the same process as PCR until the analysis step, suggesting a combination of speed and simplicity. The result of MLVA-HRMA method is able to be shared between different laboratories. There are high expectations that this method will be adopted for regular inspections at food processing facilities in the near future. Copyright © 2017. Published by Elsevier B.V.

  18. Stroke Incidence by Major Pathological Type and Ischemic Subtypes in the Auckland Regional Community Stroke Studies: Changes Between 2002 and 2011.

    Science.gov (United States)

    Krishnamurthi, Rita V; Barker-Collo, Suzanne; Parag, Varsha; Parmar, Priyakumari; Witt, Emma; Jones, Amy; Mahon, Susan; Anderson, Craig S; Barber, P Alan; Feigin, Valery L

    2018-01-01

    Major pathological stroke types (ischemic stroke [IS], primary intracerebral hemorrhage [ICH], and subarachnoid hemorrhage) and IS subtypes, have differing risk factors, management, and prognosis. We report changes in major stroke types and IS subtypes incidence during 10 years using data from the ARCOS (Auckland Regional Community Stroke Study) III performed during 12 months in 2002 to 2003 and the fourth ARCOS study (ARCOS-IV) performed in 2011 to 2012. ARCOS-III and ARCOS-IV were population-based registers of all new strokes in the greater Auckland region (population aged >15 years, 1 119 192). Strokes were classified into major pathological types (IS, ICH, subarachnoid hemorrhage, and undetermined type). Crude annual age-, sex-, and ethnic-specific stroke incidence with 95% confidence intervals was calculated. ISs were subclassified using TOAST (Trial of ORG 10172 in Acute Stroke Treatment) criteria into 5 etiologic groups. Rate ratios with 95% confidence intervals were calculated for differences in age-standardized rates between the 2 studies. In ARCOS-IV, there were 1329 (81%) ISs, 211 (13%) ICHs, 79 (5%) subarachnoid hemorrhages, and 24 (1%) undetermined type strokes. The proportional distribution of IS subtypes was 29% cardioembolism, 21% small-vessel occlusion, 15% large-artery atherosclerosis, 5% other determined etiology, and 31% undetermined type. Between 2002 and 2011, age-standardized incidence decreased for subarachnoid hemorrhage (rate ratios, 0.73; 95% confidence intervals, 0.54-0.99) and undetermined type (rate ratios, 0.14; 95% confidence intervals, 0.09-0.22). Rates were stable for IS and ICH. Among IS subtypes, large-artery atherosclerosis and small-vessel occlusion rates increased significantly. The frequency of all risk factors increased in IS. Ethnic differences were observed for both stroke subtype rates and their risk factor frequencies. A lack of change in IS and ICH incidence may reflect a trend toward increased incidence of younger

  19. A curative treatment option for Complex Regional Pain Syndrome (CRPS) Type I: dorsal root entry zone operation (report of two cases).

    Science.gov (United States)

    Kanpolat, Yucel; Al-Beyati, Eyyub; Ugur, Hasan Caglar; Akpinar, Gokhan; Kahilogullari, Gokmen; Bozkurt, Melih

    2014-01-01

    Complex Regional Pain Syndrome Type I (CRPS-I) is a debated health problem concerning its pathophysiology and treatment strategies. A 12-year-old boy and a 35-year-old woman were diagnosed with CRPS-I at different times. They had previously undergone various types of interventions with no success. After one year of follow-up and observation, DREZ lesioning operation was performed. Afterwards, both cases had transient lower extremity ataxia. The first case was followed for 60 months with no recurrence and total cure. The second case was pain-free until the 6th month, when she required psychological support; she was followed for 33 months with partial satisfactory outcome. Although not a first-line option, DREZ lesioning procedure can be chosen and may be a curative option in selected cases of CRPS-I who are unresponsive to conventional therapies.

  20. Use of reconstructed CT images for evaluation of the position of screw-type temporary anchorage devices implanted in the maxillary molar region

    International Nuclear Information System (INIS)

    Hashimoto, Kazuya

    2007-01-01

    Temporary anchorage devices (TAD) have recently been employed for orthodontic treatment. I attempted to find the safest position for placing the screw-type TAD in the maxillary molar region. Using reconstructed CT images, I investigated the buccolingual and mesiodistal lengths of the interalveolar septums between the maxillary first premolar, second premolar, first molar, and the second molar. For the first and second molars, I measured the distance from the alveolar crest to the maxillary sinus. The results indicated that the safest position for placing a screw-type TAD was the interalveolar septum between the maxillary first molar and the second premolar at about a depth of 4-6 mm from the alveolar crest on the buccal side, and at about a depth of 2-6 mm from the alveolar crest on the palatal side. (author)

  1. Assessment of carbon pools in two soils from the Campania region (Southwest, Italy) under different forest types

    Science.gov (United States)

    Álvarez-Romero, Marta; Papa, Stefania; Lozano-García, Beatriz; Parras-Alcántara, Luis; González-Pérez, José A.; Jordán, Antonio; Zavala, Lorena M.; González-Vila, Francisco J.; Coppola, Elio

    2014-05-01

    Soil is the largest carbon reservoir of terrestrial ecosystems, this reservoir is not inert, but it is constantly in a dynamic phase of accumulation an depletion. After the addition, in the soil, of organic residues of different origin and nature, two processes can occur in charge of SOM (Soil Organic Matter) during the pedogenesis: mineralization and humification. The accumulation of SOM in soil is controlled by the balance between carbon inputs and losses through mineralization and/or leaching. In particular the humification process leads to the formation of organic compounds (in some cases even complex organo-mineral) chemically stable able to distribute itself in the soil second rules of site-specific pedogenesis. The transport process along the profile can take very different forms which may extend in the formation of Bh horizons of accumulation in depth also strongly cemented (so-called ortstein). The transport process along the profile occurs for the occurrence of certain conditions such as deposition of high amounts of organic residues on the top of the profile, high porosity of the soil for the presence of coarse solid fractions (coarse sands or skeleton) that determinate a strong infiltrating capacity of the circulating waters, extreme temperatures can slow or stop the process of mineralization and/or humification in one intermediate step of the degradation process releasing organic metabolites with high or medium solubility and high loads of percolating water related to intense rainfall. The nature of the forest cover influence the quantity and quality of the organic materials deposited with marked differences between coniferous and deciduous especially in relation to resistance to degradation and production of intermediate metabolites. Two soils from Campania region located in Monte Santa Croce (Caserta, Italy) with andic properties, different forest cover (pine and chestnut) and that meets the requirements of the place and pedological formation

  2. Complex regional pain syndrome type I in the upper extremity - how efficient physical therapy and rehabilitation are.

    Science.gov (United States)

    Zečević Luković, Tanja; Ristić, Branko; Jovanović, Zorica; Rančić, Nemanja; Ignjatović Ristić, Dragana; Cuković, Saša

    2012-08-01

    To evaluate the effects of early started combined therapy in Complex Regional Pain Syndrome-1 (CRPS-1) on the upper extremities. The study included 36 patients in the first stadium of CRPS-1 on the upper extremities The mean age of patients was 42.6±14.6, the majority of them (26 of 36) were females. The right side of the upper extremity was affected much more then the left side. They were treated by combined therapy including analgetics, electrotherapy, magneto therapy and kinesitherapy. The average length of observation was 172.1 days (from 90 to 250 days). The average length of treatment was 91.5±42.16 days. Intensity of pain, swelling of the extremity, the change in skin coloration and cutaneous manifestations were assessed three times, at the beginning of the treatment, after 6 weeks and at the end of the treatment. The pain was registered in all patients at visit 1 (average pain intensity was 5.70 ±1.44 on 100 mm visual analogue scale), and it was progressively decreased during the treatment from 3.60±1.22 at the second visit to 0.34±0.68 at the third visit. Vasodilatation was registered in 30 (83.33%) patients and skin temperature asymmetries was found in 21 (58.33%) patients. The difference of size was detected in 30 (83.33%) patients at the first visit compared to four (11.11%) patients at the end of the treatment. There were six (16.66%) patients without swelling at the beginning compared to 26 (72.22%) at the end of the treatment (p less than 0.000). Complete healing was achieved in 32 patients (88.88%). The carefully chosen physical agents in combination with analgesic and non-steroidal anti-inflammatory drugs may benefit in patients with CRPS-1 on the upper extremity if the treatment starts as soon as possible.

  3. Why not Commercial Assistance for Suicide? On the Question of Argumentative Coherence of Endorsing Assisted Suicide.

    Science.gov (United States)

    Kipke, Roland

    2015-09-01

    Most people who endorse physician-assisted suicide are against commercially assisted suicide - a suicide assisted by professional non-medical providers against payment. The article questions if this position - endorsement of physician-assisted suicide on the one hand and rejection of commercially assisted suicide on the other hand - is a coherent ethical position. To this end the article first discusses some obvious advantages of commercially assisted suicide and then scrutinizes six types of argument about whether they can justify the rejection of commercially assisted suicide while simultaneously endorsing physician-assisted suicide. The conclusion is that they cannot provide this justification and that the mentioned position is not coherent. People who endorse physician-assisted suicide have to endorse commercially assisted suicide as well, or they have to revise their endorsement of physician-assisted suicide. © 2014 John Wiley & Sons Ltd.

  4. 25 CFR 41.10 - Technical assistance.

    Science.gov (United States)

    2010-04-01

    ... Community College's request in writing. In any case, where the type and source of technical assistance is... for technical assistance under this section shall be made in writing and sent to the applicant within... 25 Indians 1 2010-04-01 2010-04-01 false Technical assistance. 41.10 Section 41.10 Indians BUREAU...

  5. Foreign assistance

    International Nuclear Information System (INIS)

    1991-07-01

    This paper reports that providing energy assistance to developing countries remains a relatively low priority of the Agency for International Development. AID is helping some developing countries meet their energy needs, but this assistance varies substantially because of the agency's decentralized structure. Most AID energy funding has gone to a handful of countries-primarily Egypt and Pakistan. With limited funding in most other countries, AID concentrates on providing technical expertise and promoting energy policy reforms that will encourage both energy efficiency and leverage investment by the private sector and other donors. Although a 1989 congressional directive to pursue a global warming initiative has had a marginal impact on the agency's energy programming, many AID energy programs, including those directed at energy conservation, help address global warming concerns

  6. Neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress in rats with streptozotocin-induced type 1 diabetes

    Directory of Open Access Journals (Sweden)

    Sang Gun Lee

    2015-01-01

    Full Text Available In this study, we investigated the effects of streptozotocin-induced type 1 diabetes on antioxidant-like protein-1 immunoreactivity, protein carbonyl levels, and malondialdehyde formation, a marker for lipid peroxidation, in the hippocampus. For this study, streptozotocin (75 mg/kg was intraperitoneally injected into adult rats to induce type 1 diabetes. The three experimental parameters were determined at 2, 3, 4 weeks after streptozotocin treatment. Fasting blood glucose levels significantly increased by 20.7-21.9 mM after streptozotocin treatment. The number of antioxidant-like protein-1 immunoreactive neurons significantly decreased in the hippocampal CA1 region, but not the dentate gyrus, 3 weeks after streptozotocin treatment compared to the control group. Malondialdehyde and protein carbonyl levels, which are modified by oxidative stress, significantly increased with a peak at 3 weeks after malondialdehyde treatment, and then decreased 4 weeks after malondialdehyde treatment. These results suggest that neurons in the hippocampal CA1 region, but not the dentate gyrus, are susceptible to oxidative stress 3 weeks after malondialdehyde treatment.

  7. Prevalence and clinical presentation at the onset of type 1 diabetes mellitus among children and adolescents in AL-Baha region, Saudi Arabia.

    Science.gov (United States)

    Al-Ghamdi, Ahmed Hassan; Fureeh, Abdelhameed Ahmed

    2018-03-28

    The objectives were to describe the frequency of clinical presentation at the onset of type 1 diabetes mellitus (T1DM) and to estimate the prevalence of T1DM among children and adolescents in the AL-Baha region, Saudi Arabia, aiming for early diagnosis of T1DM. The clinical and laboratory data of 471 children and adolescents who presented with T1DM and received medical care at an AL-Baha diabetic center during the period from 2007 to 2016 were retrospectively analyzed based on the records. The prevalence of T1DM in the AL-Baha region was 355 per 100,000 population in participants aged from 0 to 19 years. T1DM was more common among girls than boys (57.5% vs. 42.5%, respectively; p=0.3), and the female/male ratio was 1.36 in favor of girls. Hyperglycemic symptoms were the most frequent symptoms at presentation [59.2% vs. 40.8% with diabetic ketoacidosis (DKA)], and 37% of them presented with loss of weight. Most of the ketoacidosis was mild to moderate (80.2%), while only 19.8% of children had the severe type and DKA was more common (55.2%) among females. The mean age at diagnosis of T1DM was 8.2±3.5 years for all patients, and 8.3±3.9 and 8.9±3.6 years for boys and girls, respectively (p=0.06). Hyperglycemic symptoms were more common in spring (15.9%). The prevalence of type 1 diabetes in the AL-Baha region was 355 per 100,000 population, which is one of the highest reported prevalences in this age group. Hyperglycemic symptoms were the most encountered symptoms at the onset of the presentation of T1DM and this may help in early detection of diabetic symptoms by patients and physicians to avoid the more severe types of presentation.

  8. Regional specific binding of [11C]RO 15 1788 to central type benzodiazepine receptors in human brain: quantitative evaluation by PET

    International Nuclear Information System (INIS)

    Pappata, S.; Samson, Y.; Chavoix, C.; Prenant, C.; Maziere, M.; Baron, J.C.

    1988-01-01

    The central type benzodiazepine receptors were studied in 17 healthy human subjects with 11 C-RO 15 1788 and positron emission tomography (PET). The brain regional distribution of the tracer in eight control studies performed after injection of trace doses of 11 C-RO 15 1788 was consistent with that of benzodiazepine receptors. Saturation studies with co-injected cold RO 15 1788 in the remaining subjects showed a dose-dependent decrease of brain radiotracer until full inhibition of specific binding was achieved with doses above 0.1 mg/kg (four studies). Based on the results, a simple method to estimate the specifically bound 11 C-RO 15 1788 regionally in a single PET study is proposed, using the data from the full-saturation studies as a stable estimate of the nondisplaceable radioligand concentration. Using this method, it was found that quasiequilibrium between the estimated specifically bound and nondisplaceable components was achieved at times equal to or longer than 20 min after tracer administration. The validity of this method was partly supported by further results, showing a good agreement between the regional specific binding so calculated and postmortem data of receptor density

  9. Dietary sodium deprivation evokes activation of brain regional neurons and down-regulation of angiotensin II type 1 receptor and angiotensin-convertion enzyme mRNA expression.

    Science.gov (United States)

    Lu, B; Yang, X J; Chen, K; Yang, D J; Yan, J Q

    2009-12-15

    Previous studies have indicated that the renin-angiotensin-aldosterone system (RAAS) is implicated in the induction of sodium appetite in rats and that different dietary sodium intakes influence the mRNA expression of central and peripheral RAAS components. To determine whether dietary sodium deprivation activates regional brain neurons related to sodium appetite, and changes their gene expression of RAAS components of rats, the present study examined the c-Fos expression after chronic exposure to low sodium diet, and determined the relationship between plasma and brain angiotensin I (ANG I), angiotensin II (ANG II) and aldosterone (ALD) levels and the sodium ingestive behavior variations, as well as the effects of prolonged dietary sodium deprivation on ANG II type 1 (AT1) and ANG II type 2 (AT2) receptors and angiotensin-convertion enzyme (ACE) mRNA levels in the involved brain regions using the method of real-time polymerase chain reaction (PCR). Results showed that the Fos immunoreactivity (Fos-ir) expression in forebrain areas such as subfornical organ (SFO), paraventricular hypothalamic nuclei (PVN), supraoptic nucleus (SON) and organum vasculosum laminae terminalis (OVLT) all increased significantly and that the levels of ANG I, ANG II and ALD also increased in plasma and forebrain in rats fed with low sodium diet. In contrast, AT1, ACE mRNA in PVN, SON and OVLT decreased significantly in dietary sodium depleted rats, while AT2 mRNA expression did not change in the examined areas. These results suggest that many brain areas are activated by increased levels of plasma and/or brain ANG II and ALD, which underlies the elevated preference for hypertonic salt solution after prolonged exposure to low sodium diet, and that the regional AT1 and ACE mRNA are down-regulated after dietary sodium deprivation, which may be mediated by increased ANG II in plasma and/or brain tissue.

  10. Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes.

    Science.gov (United States)

    Roshandel, Delnaz; Gubitosi-Klug, Rose; Bull, Shelley B; Canty, Angelo J; Pezzolesi, Marcus G; King, George L; Keenan, Hillary A; Snell-Bergeon, Janet K; Maahs, David M; Klein, Ronald; Klein, Barbara E K; Orchard, Trevor J; Costacou, Tina; Weedon, Michael N; Oram, Richard A; Paterson, Andrew D

    2018-05-01

    The aim of this study was to identify genetic variants associated with beta cell function in type 1 diabetes, as measured by serum C-peptide levels, through meta-genome-wide association studies (meta-GWAS). We performed a meta-GWAS to combine the results from five studies in type 1 diabetes with cross-sectionally measured stimulated, fasting or random C-peptide levels, including 3479 European participants. The p values across studies were combined, taking into account sample size and direction of effect. We also performed separate meta-GWAS for stimulated (n = 1303), fasting (n = 2019) and random (n = 1497) C-peptide levels. In the meta-GWAS for stimulated/fasting/random C-peptide levels, a SNP on chromosome 1, rs559047 (Chr1:238753916, T>A, minor allele frequency [MAF] 0.24-0.26), was associated with C-peptide (p = 4.13 × 10 -8 ), meeting the genome-wide significance threshold (p C>T, MAF 0.07-0.10, p = 8.43 × 10 -8 ). In the stimulated C-peptide meta-GWAS, rs61211515 (Chr6:30100975, T/-, MAF 0.17-0.19) in the MHC region was associated with stimulated C-peptide (β [SE] = - 0.39 [0.07], p = 9.72 × 10 -8 ). rs61211515 was also associated with the rate of stimulated C-peptide decline over time in a subset of individuals (n = 258) with annual repeated measures for up to 6 years (p = 0.02). In the meta-GWAS of random C-peptide, another MHC region, SNP rs3135002 (Chr6:32668439, C>A, MAF 0.02-0.06), was associated with C-peptide (p = 3.49 × 10 -8 ). Conditional analyses suggested that the three identified variants in the MHC region were independent of each other. rs9260151 and rs3135002 have been associated with type 1 diabetes, whereas rs559047 and rs61211515 have not been associated with a risk of developing type 1 diabetes. We identified a locus on chromosome 1 and multiple variants in the MHC region, at least some of which were distinct from type 1 diabetes risk loci, that were associated with C

  11. n-type dopants in (001) β-Ga2O3 grown on (001) β-Ga2O3 substrates by plasma-assisted molecular beam epitaxy

    Science.gov (United States)

    Han, Sang-Heon; Mauze, Akhil; Ahmadi, Elaheh; Mates, Tom; Oshima, Yuichi; Speck, James S.

    2018-04-01

    Ge and Sn as n-type dopants in (001) β-Ga2O3 films were investigated using plasma-assisted molecular beam epitaxy. The Ge concentration showed a strong dependence on the growth temperature, whereas the Sn concentration remains independent of the growth temperature. The maximum growth temperature at which a wide range of Ge concentrations (from 1017 to 1020 cm-3) could be achieved was 675 °C while the same range of Sn concentration could be achieved at growth temperature of 750 °C. Atomic force microscopy results revealed that higher growth temperature shows better surface morphology. Therefore, our study reveals a tradeoff between higher Ge doping concentration and high quality surface morphology on (001) β-Ga2O3 films grown by plasma-assisted molecular beam epitaxy. The Ge doped films had an electron mobility of 26.3 cm2 V-1 s-1 at the electron concentration of 6.7 × 1017 cm-3 whereas the Sn doped films had an electron mobility of 25.3 cm2 V-1 s-1 at the electron concentration of 1.1 × 1018 cm-3.

  12. Randomized trial of technology-assisted self-monitoring of blood glucose by low-income seniors: improved glycemic control in type 2 diabetes mellitus.

    Science.gov (United States)

    Levine, Jason C; Burns, Edith; Whittle, Jeffrey; Fleming, Raymond; Knudson, Paul; Flax, Steve; Leventhal, Howard

    2016-12-01

    Self-monitoring of blood glucose (SMBG) has been recommended for people with type 2 diabetes mellitus. This trial tested an automated self-management monitor (ASMM) that reminds patients to perform SMBG, provides feedback on results of SMBG, and action tips for improved self-management. This delayed-start trial randomized participants to using the ASMM immediately (IG), or following a delay of 6 months (DG). Glycated hemoglobin (HgbA1c) level and survey data was collected at home visits every 3 months. 44 diabetic men and women, mean age 70, completed the 12-month trial. Baseline HgbA1c was 8.1 % ± 1.0, dropping to 7.3 ± 1.0 by 9 months, with a 3-month lag in the DG (F = 3.56, p = 0.004). Decrease in HgbA1c was significantly correlated to increased frequency of SMBG, R = 0.588, p better glycemic control. This type of technology may provide real-time feedback not only to patient users, but to the health care system, allowing better integration of provider recommendations with patient-centered action.

  13. Assessment of Non-Point Source Total Phosphorus Pollution from Different Land Use and Soil Types in a Mid-High Latitude Region of China

    Directory of Open Access Journals (Sweden)

    Zhiwei Wang

    2016-11-01

    Full Text Available The transport characteristics of phosphorus in soil and the assessment of its environmental risk have become hot topics in the environmental and agricultural fields. The Sanjiang Plain is an important grain production base in China, and it is characterised by serious land use change caused by large-scale agricultural exploitation. Agricultural inputs and tillage management have destroyed the soil nutrient balance formed over long-term conditions. There are few studies on non-point source phosphorus pollution in the Sanjiang Plain, which is the largest swampy low plain in a mid-high-latitude region in China. Most studies have focused on the water quality of rivers in marsh areas, or the export mechanism of phosphorus from specific land uses. They were conducted using experimental methods or empirical models, and need further development towards mechanism models and the macro-scale. The question is how to find a way to couple processes in phosphorus cycling and a distributed hydrological model considering local hydrological features. In this study, we report an attempt to use a distributed phosphorus transport model to analyse non-point source total phosphorus pollution from different land uses and soil types on the Sanjiang Plain. The total phosphorus concentration generally shows an annually increasing trend in the study area. The total phosphorus load intensity is heterogeneous in different land use types and different soil types. The average total phosphorus load intensity of different land use types can be ranked in descending order from paddy field, dry land, wetlands, grassland, and forestland. The average total phosphorus load intensity of different soil types can be ranked in descending order: paddy soil, bog soil, planosol, meadow soil, black soil, and dark brown earth. The dry land and paddy fields account for the majority of total phosphorus load in the study area. This is mainly caused by extensive use of phosphate fertilizer on the

  14. Mapping Distinct Forest Types Improves Overall Forest Identification Based on Multi-Spectral Landsat Imagery for Myanmar’s Tanintharyi Region

    Directory of Open Access Journals (Sweden)

    Grant Connette

    2016-10-01

    Full Text Available We investigated the use of multi-spectral Landsat OLI imagery for delineating mangrove, lowland evergreen, upland evergreen and mixed deciduous forest types in Myanmar’s Tanintharyi Region and estimated the extent of degraded forest for each unique forest type. We mapped a total of 16 natural and human land use classes using both a Random Forest algorithm and a multivariate Gaussian model while considering scenarios with all natural forest classes grouped into a single intact or degraded category. Overall, classification accuracy increased for the multivariate Gaussian model with the partitioning of intact and degraded forest into separate forest cover classes but slightly decreased based on the Random Forest classifier. Natural forest cover was estimated to be 80.7% of total area in Tanintharyi. The most prevalent forest types are upland evergreen forest (42.3% of area and lowland evergreen forest (21.6%. However, while just 27.1% of upland evergreen forest was classified as degraded (on the basis of canopy cover <80%, 66.0% of mangrove forest and 47.5% of the region’s biologically-rich lowland evergreen forest were classified as degraded. This information on the current status of Tanintharyi’s unique forest ecosystems and patterns of human land use is critical to effective conservation strategies and land-use planning.

  15. CT-guided stellate ganglion blockade vs. radiofrequency neurolysis in the management of refractory type I complex regional pain syndrome of the upper limb

    Energy Technology Data Exchange (ETDEWEB)

    Kastler, Adrian [University Hospital CHU Gabriel Montpied, Radiology Department, Clermont-Ferrand (France); Franche Comte University, I4S Laboratory-EA 4268-IFR 133, Besancon (France); CHU Clermont-Ferrand, Hopital Gabriel Montpied, Clermont-Ferrand (France); Aubry, Sebastien; Kastler, Bruno [University Hospital CHU Jean Minjoz, Radiology and Interventional Pain Unit, Besancon (France); Franche Comte University, I4S Laboratory-EA 4268-IFR 133, Besancon (France); Sailley, Nicolas; Michalakis, Demosthene [University Hospital CHU Jean Minjoz, Radiology and Interventional Pain Unit, Besancon (France); Siliman, Gaye [University Hospital CHU St Jacques, Clinical Investigation Center, Besancon (France); Gory, Guillaume [Franche Comte University, I4S Laboratory-EA 4268-IFR 133, Besancon (France); Lajoie, Jean-Louis [University Hospital CHU Jean Minjoz, Pain evaluation and Management Unit, Besancon (France)

    2013-05-15

    To describe and evaluate the feasibility and efficacy of CT-guided radiofrequency neurolysis (RFN) vs. local blockade of the stellate ganglion in the management of chronic refractory type I complex regional pain syndrome (CRPS) of the upper limb. Sixty-seven patients were included in this retrospective study between 2000 and 2011. All suffered from chronic upper limb type I CRPS refractory to conventional pain therapies. Thirty-three patients underwent stellate ganglion blockade and 34 benefited from radiofrequency neurolysis of the stellate ganglion. CT guidance was used in both groups. The procedure was considered effective when pain relief was {>=}50 %, lasting for at least 2 years. Thirty-nine women (58.2 %) and 28 men (41.8 %) with a mean age of 49.5 years were included in the study. Univariate analysis performed on the blockade and RFN groups showed a significantly (P < 0.0001) higher success rate in the RFN group (67.6 %, 23/34) compared with the blockade group (21.2 %, 7/33) with an odds ratio of 7.76. CT-guided radiofrequency neurolysis of the stellate ganglion is a safe and successful treatment of chronic refractory type I CRPS of the upper limb. It appears to be more effective than stellate ganglion blockade. (orig.)

  16. Radioactive waste management at WWER type reactors

    International Nuclear Information System (INIS)

    1993-05-01

    This report was prepared within the framework of the Technical Assistance Regional Project on Advice on Waste Management at WWER Type Reactors, which was initiated by the IAEA in 1991. The Regional Project is an integral part of the IAEA's activities directed towards improvement of the safety and reliability of nuclear power plants with WWER type reactors (Soviet designed PWRs). Forty-five WWER type units are currently in operation and twenty-five are under construction in Bulgaria, Czechoslovakia, Finland, Hungary and the former USSR. The idea of regional collaboration between eastern European countries under the auspices of the IAEA was discussed for the first time during the last meeting of the Council for Mutual Economic Assistance (CMEA) on spent fuel and radioactive waste management, held in Rez, Czechoslovakia, in October 1990. Since then, the CMEA and some of its former Member States have ceased to exist. However, there are many reasons for eastern European countries to continue their regional collaboration at a higher level. The USSR, the designer and supplier of WWER type reactors in eastern European countries, participated in the first phase of the project. The majority of WWER type reactors are situated in States of the former USSR (Russia and Ukraine). The main results of the first phase of the Regional Project are: (i) Re-establishment of communication channels among eastern European countries operating WWER type reactors by incorporating t