WorldWideScience

Sample records for assess health risks

  1. Exploration Health Risks: Probabilistic Risk Assessment

    Science.gov (United States)

    Rhatigan, Jennifer; Charles, John; Hayes, Judith; Wren, Kiley

    2006-01-01

    Maintenance of human health on long-duration exploration missions is a primary challenge to mission designers. Indeed, human health risks are currently the largest risk contributors to the risks of evacuation or loss of the crew on long-duration International Space Station missions. We describe a quantitative assessment of the relative probabilities of occurrence of the individual risks to human safety and efficiency during space flight to augment qualitative assessments used in this field to date. Quantitative probabilistic risk assessments will allow program managers to focus resources on those human health risks most likely to occur with undesirable consequences. Truly quantitative assessments are common, even expected, in the engineering and actuarial spheres, but that capability is just emerging in some arenas of life sciences research, such as identifying and minimize the hazards to astronauts during future space exploration missions. Our expectation is that these results can be used to inform NASA mission design trade studies in the near future with the objective of preventing the higher among the human health risks. We identify and discuss statistical techniques to provide this risk quantification based on relevant sets of astronaut biomedical data from short and long duration space flights as well as relevant analog populations. We outline critical assumptions made in the calculations and discuss the rationale for these. Our efforts to date have focussed on quantifying the probabilities of medical risks that are qualitatively perceived as relatively high risks of radiation sickness, cardiac dysrhythmias, medically significant renal stone formation due to increased calcium mobilization, decompression sickness as a result of EVA (extravehicular activity), and bone fracture due to loss of bone mineral density. We present these quantitative probabilities in order-of-magnitude comparison format so that relative risk can be gauged. We address the effects of

  2. Health effects of risk-assessment categories

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, C.F.; Rybicka, K.; Knutson, A.; Morris, S.C.

    1983-10-01

    Environmental and occupational health effects associated with exposures to various chemicals are a subject of increasing concern. One recently developed methodology for assessing the health impacts of various chemical compounds involves the classification of similar chemicals into risk-assessment categories (RACs). This report reviews documented human health effects for a broad range of pollutants, classified by RACs. It complements other studies that have estimated human health effects by RAC based on analysis and extrapolation of data from animal research.

  3. Assessment of health risks of policies

    Energy Technology Data Exchange (ETDEWEB)

    Ádám, Balázs, E-mail: badam@cmss.sdu.dk [Unit for Health Promotion Research, Faculty of Health Sciences, University of Southern Denmark, Niels Bohrs Vej 9, DK-6700 Esbjerg (Denmark); Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, P.O. Box 9, H-4012 Debrecen (Hungary); Molnár, Ágnes, E-mail: MolnarAg@smh.ca [Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, P.O. Box 9, H-4012 Debrecen (Hungary); Centre for Research on Inner City Health, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael' s Hospital, Victoria 209, Rm. 3-26.22, M5B 1C6 Toronto, Ontario (Canada); Ádány, Róza, E-mail: adany.roza@sph.unideb.hu [Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, P.O. Box 9, H-4012 Debrecen (Hungary); Bianchi, Fabrizio, E-mail: Fabriepi@ifc.cnr.it [Unit of Environmental Epidemiology, Institute of Clinical Physiology, National Council of Research, Moruzzi 1, 56124 Pisa (Italy); Bitenc, Katarina, E-mail: katarina.bitenc@ivz-rs.si [National Institute of Public Health, Trubarjeva 2, SI-1000 Ljubljana (Slovenia); Chereches, Razvan, E-mail: razvan.m.chereches@gmail.com [Faculty of Political, Administrative and Communication Sciences, Babes-Bolyai University, Strada Mihail Kogalniceanu 1, 3400 Cluj (Romania); Cori, Liliana, E-mail: liliana.cori@ifc.cnr.it [Unit of Environmental Epidemiology, Institute of Clinical Physiology, National Council of Research, Moruzzi 1, 56124 Pisa (Italy); Fehr, Rainer, E-mail: rainer.fehr@uni-bielefeld.de [NRW Centre for Health, Westerfeldstr. 35-37, 33611 Bielefeld (Germany); Kobza, Joanna, E-mail: koga1@poczta.onet.pl [Public Health Department, Silesian Medical University, 18 Medykow Street, 40-752 Katowice (Poland); Kollarova, Jana, E-mail: janakollarova@yahoo.com [Department of Health Promotion, Regional Public Health Authority, Ipelska 1, 04011 Kosice (Slovakia); and others

    2014-09-15

    The assessment of health risks of policies is an inevitable, although challenging prerequisite for the inclusion of health considerations in political decision making. The aim of our project was to develop a so far missing methodological guide for the assessment of the complex impact structure of policies. The guide was developed in a consensual way based on experiences gathered during the assessment of specific national policies selected by the partners of an EU project. Methodological considerations were discussed and summarized in workshops and pilot tested on the EU Health Strategy for finalization. The combined tool, which includes a textual guidance and a checklist, follows the top-down approach, that is, it guides the analysis of causal chains from the policy through related health determinants and risk factors to health outcomes. The tool discusses the most important practical issues of assessment by impact level. It emphasises the transparent identification and prioritisation of factors, the consideration of the feasibility of exposure and outcome assessment with special focus on quantification. The developed guide provides useful methodological instructions for the comprehensive assessment of health risks of policies that can be effectively used in the health impact assessment of policy proposals. - Highlights: • Methodological guide for the assessment of health risks of policies is introduced. • The tool is developed based on the experiences from several case studies. • The combined tool consists of a textual guidance and a checklist. • The top-down approach is followed through the levels of the full impact chain. • The guide provides assistance for the health impact assessment of policy proposals.

  4. Risk assessment in support of plant health

    DEFF Research Database (Denmark)

    Jeger, Michael; Schans, Jan; Lövei, Gabor L.

    2012-01-01

    types and plants in the environment. There has been an increasing trend towards producing scientific opinions which are full pest risk assessments for the whole EU territory. In its work, and as a contribution to the wider development of risk assessment methodology, the Panel has developed a series......-evaluation of quantitative pathway analyses, and in statistical modelling of experimental data. A Plant Health Network has been established to facilitate interaction with EU Member States, especially in relation to data collection and co-ordination of risk assessment activities. At the current time a revision of the EU...

  5. Assessment factors for human health risk assessment: A discussion paper

    NARCIS (Netherlands)

    Vermeire, T.; Stevenson, H.; Pieters, M.N.; Rennen, M.; Slob, W.; Hakkert, B.C.

    1999-01-01

    The general goal of this discussion paper is to contribute toward the further harmonization of human health risk assessment. It first discusses the development of a formal, harmonized set of assessment factors. The status quo with regard to assessment factors is reviewed, that is, the type of factor

  6. The relation of risk assessment and health impact assessment

    DEFF Research Database (Denmark)

    Ádám, Balázs; Gulis, Gabriel

    2013-01-01

    as a powerful tool for the evaluation of potential health consequences of planned measures. It is often discussed whether HIA is not just another term or form of risk assessment and what is their relation. Our aim is to discuss similarities and differences between the two methods so as to clarify......The level and distribution of health risks in a society is substantially influenced by measures of various policies, programmes or projects. Risk assessment can evaluate the nature, likelihood and severity of an adverse effect. Health impact assessment (HIA) provides similar function when used...... standardised scientific methods to characterise the probability and magnitude of harm caused by a hazard, preferably in a quantitative manner. In turn, HIA is a process to assess future impacts of recent proposals and is dominated by qualitative evaluation. It makes a projection for a future scenario rather...

  7. A dynamic human health risk assessment system.

    Science.gov (United States)

    Prasad, Umesh; Singh, Gurmit; Pant, A B

    2012-05-01

    An online human health risk assessment system (OHHRAS) has been designed and developed in the form of a prototype database-driven system and made available for the population of India through a website - www.healthriskindia.in. OHHRAS provide the three utilities, that is, health survey, health status, and bio-calculators. The first utility health survey is functional on the basis of database being developed dynamically and gives the desired output to the user on the basis of input criteria entered into the system; the second utility health status is providing the output on the basis of dynamic questionnaire and ticked (selected) answers and generates the health status reports based on multiple matches set as per advise of medical experts and the third utility bio-calculators are very useful for the scientists/researchers as online statistical analysis tool that gives more accuracy and save the time of user. The whole system and database-driven website has been designed and developed by using the software (mainly are PHP, My-SQL, Deamweaver, C++ etc.) and made available publically through a database-driven website (www.healthriskindia.in), which are very useful for researchers, academia, students, and general masses of all sectors.

  8. Assessing Your Weight and Health Risk

    Science.gov (United States)

    ... 0–29.9 Obesity 30.0 and Above Waist Circumference Measuring waist circumference helps screen for possible health risks that come ... Risks of Obesity-Associated Diseases by BMI and Waist Circumference provides you with an idea of whether your ...

  9. Study of occupation health risk assessment on Chinese coal mine

    Institute of Scientific and Technical Information of China (English)

    XIAO Guo-qing; YAN Xiang-nong

    2007-01-01

    Factors of occupation health hazard were identified and analyzed, and indexes system of occupation health risk assessment were established by applying fuzzy theory and system safety technique, the weights of index system were obtained by AHP, finally a reasonable mathematics model of occupation health risk assessment was accomplished by an example.

  10. 2011 Behavioral Health Risk Assessment Data Report (BH-RADR)

    Science.gov (United States)

    2015-09-01

    Approved for public release, distribution unlimited General Medicine: 500A, Public Health Data 2011 Behavioral Health Risk Assessment Data...REPORT DATE 30 SEP 2015 2. REPORT TYPE Annual 3. DATES COVERED 01 JAN 2011 - 31 DEC 2011 4. TITLE AND SUBTITLE 2011 Behavioral Health Risk...ABSTRACT This publication describes characteristics of Soldiers who completed a behavioral health (BH) screening at the two post-deployment Touch Points

  11. Risk assessment and toxicology databases for health effects assessment

    Energy Technology Data Exchange (ETDEWEB)

    Lu, P.Y.; Wassom, J.S. [Oak Ridge National Laboratory, TN (United States)

    1990-12-31

    Scientific and technological developments bring unprecedented stress to our environment. Society has to predict the results of potential health risks from technologically based actions that may have serious, far-reaching consequences. The potential for error in making such predictions or assessment is great and multiplies with the increasing size and complexity of the problem being studied. Because of this, the availability and use of reliable data is the key to any successful forecasting effort. Scientific research and development generate new data and information. Much of the scientific data being produced daily is stored in computers for subsequent analysis. This situation provides both an invaluable resource and an enormous challenge. With large amounts of government funds being devoted to health and environmental research programs and with maintenance of our living environment at stake, we must make maximum use of the resulting data to forecast and avert catastrophic effects. Along with the readily available. The most efficient means of obtaining the data necessary for assessing the health effects of chemicals is to utilize applications include the toxicology databases and information files developed at ORNL. To make most efficient use of the data/information that has already been prepared, attention and resources should be directed toward projects that meticulously evaluate the available data/information and create specialized peer-reviewed value-added databases. Such projects include the National Library of Medicine`s Hazardous Substances Data Bank, and the U.S. Air Force Installation Restoration Toxicology Guide. These and similar value-added toxicology databases were developed at ORNL and are being maintained and updated. These databases and supporting information files, as well as some data evaluation techniques are discussed in this paper with special focus on how they are used to assess potential health effects of environmental agents. 19 refs., 5 tabs.

  12. Assessing human health risk in the USDA forest service

    Energy Technology Data Exchange (ETDEWEB)

    Hamel, D.R. [Department of Agriculture-Forest Service, Washington, DC (United States)

    1990-12-31

    This paper identifies the kinds of risk assessments being done by or for the US Department of Agriculture (USDA) Forest Service. Summaries of data sources currently in use and the pesticide risk assessments completed by the agency or its contractors are discussed. An overview is provided of the agency`s standard operating procedures for the conduct of toxicological, ecological, environmental fate, and human health risk assessments.

  13. Editorial: Lead Risk Assessment and Health Effects.

    Science.gov (United States)

    Mielke, Howard W

    2016-06-14

    In 1980, Clair C. Patterson stated: "Sometime in the near future it probably will be shown that the older urban areas of the United States have been rendered more or less uninhabitable by the millions of tons of poisonous industrial lead residues that have accumulated in cities during the past century". We live in the near future about which this quote expressed concern. This special volume of 19 papers explores the status of scientific evidence regarding Dr. Patterson's statement on the habitability of the environments of communities. Authors from 10 countries describe a variety of lead issues in the context of large and small communities, smelter sites, lead industries, lead-based painted houses, and vehicle fuel treated with lead additives dispersed by traffic. These articles represent the microcosm of the larger health issues associated with lead. The challenges of lead risk require a concerted global action for primary prevention.

  14. Editorial: Lead Risk Assessment and Health Effects

    Directory of Open Access Journals (Sweden)

    Howard W. Mielke

    2016-06-01

    Full Text Available In 1980, Clair C. Patterson stated: “Sometime in the near future it probably will be shown that the older urban areas of the United States have been rendered more or less uninhabitable by the millions of tons of poisonous industrial lead residues that have accumulated in cities during the past century”. We live in the near future about which this quote expressed concern. This special volume of 19 papers explores the status of scientific evidence regarding Dr. Patterson’s statement on the habitability of the environments of communities. Authors from 10 countries describe a variety of lead issues in the context of large and small communities, smelter sites, lead industries, lead-based painted houses, and vehicle fuel treated with lead additives dispersed by traffic. These articles represent the microcosm of the larger health issues associated with lead. The challenges of lead risk require a concerted global action for primary prevention.

  15. Selection of reproductive health end points for environmental risk assessment.

    OpenAIRE

    Savitz, D A; Harlow, S D

    1991-01-01

    In addition to the challenges inherent in environmental health risk assessment, the study of reproductive health requires thorough consideration of the very definition of reproductive risk. Researchers have yet to determine which end points need to be considered to comprehensively evaluate a community's reproductive health. Several scientific issues should be considered in the selection of end points: the severity of the outcomes, with a trade-off between clinical severity and statistical or ...

  16. Integrating a quantitative risk appraisal in a health impact assessment

    DEFF Research Database (Denmark)

    Adám, Balázs; Molnár, Agnes; Gulis, Gabriel;

    2013-01-01

    BACKGROUND: Although the quantification of health outcomes in a health impact assessment (HIA) is scarce in practice, it is preferred by policymakers, as it assists various aspects of the decision-making process. This article provides an example of integrating a quantitative risk appraisal in an ...... a practical example of applying quantification in an HIA, thereby promoting its incorporation into political decision making.......BACKGROUND: Although the quantification of health outcomes in a health impact assessment (HIA) is scarce in practice, it is preferred by policymakers, as it assists various aspects of the decision-making process. This article provides an example of integrating a quantitative risk appraisal...

  17. An economic assessment of population health risk in region

    Directory of Open Access Journals (Sweden)

    Nina Vladimirovna Zaytseva

    2012-06-01

    Full Text Available This paper proposes a method of economic assessment of population health risk as a tool of life qualitymanagement and qualityof labor resources in the region (as factors of a region’s economic security. The technique is based on the cost of reducing the period of disability in the implementation of population health risk and takes into account the effects of risk prevention on levels of the budgetary system of the Russian Federation. The method intends to support making decisions on planning measures to reduce population health risk at the level of regions, territories and separate objects to assess their cost-performance, optimization of investment and operating costs to reduce the population health risk and sustainable development of the territory

  18. Human health risk assessment of heavy metals in urban stormwater.

    Science.gov (United States)

    Ma, Yukun; Egodawatta, Prasanna; McGree, James; Liu, An; Goonetilleke, Ashantha

    2016-07-01

    Toxic chemical pollutants such as heavy metals (HMs) are commonly present in urban stormwater. These pollutants can pose a significant risk to human health and hence a significant barrier for urban stormwater reuse. The primary aim of this study was to develop an approach for quantitatively assessing the risk to human health due to the presence of HMs in stormwater. This approach will lead to informed decision making in relation to risk management of urban stormwater reuse, enabling efficient implementation of appropriate treatment strategies. In this study, risks to human health from heavy metals were assessed as hazard index (HI) and quantified as a function of traffic and land use related parameters. Traffic and land use are the primary factors influencing heavy metal loads in the urban environment. The risks posed by heavy metals associated with total solids and fine solids (heavy metal does not pose a significant risk, the presence of multiple heavy metals could be detrimental to human health. These findings suggest that stormwater guidelines should consider the combined risk from multiple heavy metals rather than the threshold concentration of an individual species. Furthermore, it was found that risk to human health from heavy metals in stormwater is significantly influenced by traffic volume and the risk associated with stormwater from industrial areas is generally higher than that from commercial and residential areas.

  19. Who comes to a workplace health risk assessment?

    Science.gov (United States)

    Dobbins, T A; Simpson, J M; Oldenburg, B; Owen, N; Harris, D

    1998-01-01

    Workplace health promotion initiatives have proliferated, but there are difficulties in recruiting employees of lower socioeconomic status and at higher risk of disease. A survey of health behaviors and attitudes was administered in 20 worksites and the opportunity to attend a health risk assessment promoted. Those more likely to attend were women, those of higher occupational prestige, and those from a non-English-speaking background. After adjustment for these variables, the only health behavior associated with attendance was smoking status. Perceived risk of lung cancer was significant, even after adjustment for smoking status. Stage of readiness to change health behaviors was associated with attendance, with those in the preparation stage being more likely to attend than those in the precontemplation stage. However, this association was statistically significant only for fruit and vegetable consumption. There was no relation between attendance and support for health promotion, perceived general health, or other perceived risk of disease. These findings suggest that additional risk communication strategies and environmental support are required to involve those with less prestigious occupations.

  20. Survey of Ambient Air Pollution Health Risk Assessment Tools.

    Science.gov (United States)

    Anenberg, Susan C; Belova, Anna; Brandt, Jørgen; Fann, Neal; Greco, Sue; Guttikunda, Sarath; Heroux, Marie-Eve; Hurley, Fintan; Krzyzanowski, Michal; Medina, Sylvia; Miller, Brian; Pandey, Kiran; Roos, Joachim; Van Dingenen, Rita

    2016-09-01

    Designing air quality policies that improve public health can benefit from information about air pollution health risks and impacts, which include respiratory and cardiovascular diseases and premature death. Several computer-based tools help automate air pollution health impact assessments and are being used for a variety of contexts. Expanding information gathered for a May 2014 World Health Organization expert meeting, we survey 12 multinational air pollution health impact assessment tools, categorize them according to key technical and operational characteristics, and identify limitations and challenges. Key characteristics include spatial resolution, pollutants and health effect outcomes evaluated, and method for characterizing population exposure, as well as tool format, accessibility, complexity, and degree of peer review and application in policy contexts. While many of the tools use common data sources for concentration-response associations, population, and baseline mortality rates, they vary in the exposure information source, format, and degree of technical complexity. We find that there is an important tradeoff between technical refinement and accessibility for a broad range of applications. Analysts should apply tools that provide the appropriate geographic scope, resolution, and maximum degree of technical rigor for the intended assessment, within resources constraints. A systematic intercomparison of the tools' inputs, assumptions, calculations, and results would be helpful to determine the appropriateness of each for different types of assessment. Future work would benefit from accounting for multiple uncertainty sources and integrating ambient air pollution health impact assessment tools with those addressing other related health risks (e.g., smoking, indoor pollution, climate change, vehicle accidents, physical activity).

  1. The Relation between Adolescent Self Assessment of Health and Risk Behaviours: Could a Global Measure of Health Provide Indications of Health Risk Exposures?

    Science.gov (United States)

    Nkansah-Amankra, Stephen; Walker, Ashley Dawn

    2012-01-01

    Objective: Self-rated health (SRH) has become a key organizing construct for assessing multiple dimensions of populations' physical and psychosocial health functioning. However, it is unclear how adolescents' subjective self assessment of health reflects health risk exposures, co-occurring health risks (problem behaviours) and other pre-existing…

  2. Health Risk Assessment for Cyanobacterial Toxins in Seafood

    Directory of Open Access Journals (Sweden)

    Andrew Humpage

    2012-03-01

    Full Text Available Cyanobacteria (blue-green algae are abundant in fresh, brackish and marine waters worldwide. When toxins produced by cyanobacteria are present in the aquatic environment, seafood harvested from these waters may present a health hazard to consumers. Toxicity hazards from seafood have been internationally recognised when the source is from marine algae (dinoflagellates and diatoms, but to date few risk assessments for cyanobacterial toxins in seafood have been presented. This paper estimates risk from seafood contaminated by cyanobacterial toxins, and provides guidelines for safe human consumption.

  3. Assessing Community Health Risks: Proactive Vs Reactive Sampling

    Directory of Open Access Journals (Sweden)

    Sarah Taylor

    2009-01-01

    Full Text Available Problem statement: A considerable number of native birds died in the West Australian coastal town of Esperance and surroundings during late 2006 and early 2007, which raised community concerns about environmental contamination. Forensic investigations of dead birds suggested that lead may have been the causative agent. At the time, lead and nickel, as well as iron ore and other materials, were being exported through the Port of Esperance (port. Government agencies undertook a targeted environmental sampling programme to identify the exposure sources and the extent of contamination. Results of ambient air monitoring, blood lead level investigations and analysis of metals in rainwater tanks suggested widespread contamination of the Esperance town site with lead and nickel. The Department of Environment and Conservation (DEC retained Golder Associates Pty Ltd., (Golder to undertake a human health and ecological risk assessment (risk assessment using the information collected through the investigation of lead and nickel contamination in Esperance. The quantity and quality of exposure data are an important contributor to the uncertainty associated with the outcomes of a risk assessment. Conclusion: As the data were collected essentially as part of the emergency response to the events in Esperance, there was some uncertainty about the suitability and completeness of the data for risk assessment. The urgent nature of the emergency response meant that sampling was opportunistic and not necessarily sufficient or suitable for risk assessment from a methodical and scientific perspective. This study demonstrated the need for collecting ‘meaningful and reliable’ data for assessing risks from environmental contamination.

  4. Environmental health risk assessment and management for global climate change

    Science.gov (United States)

    Carter, P.

    2014-12-01

    This environmental health risk assessment and management approach for atmospheric greenhouse gas (GHG) pollution is based almost entirely on IPCC AR5 (2014) content, but the IPCC does not make recommendations. Large climate model uncertainties may be large environmental health risks. In accordance with environmental health risk management, we use the standard (IPCC-endorsed) formula of risk as the product of magnitude times probability, with an extremely high standard of precaution. Atmospheric GHG pollution, causing global warming, climate change and ocean acidification, is increasing as fast as ever. Time is of the essence to inform and make recommendations to governments and the public. While the 2ºC target is the only formally agreed-upon policy limit, for the most vulnerable nations, a 1.5ºC limit is being considered by the UNFCCC Secretariat. The Climate Action Network International (2014), representing civil society, recommends that the 1.5ºC limit be kept open and that emissions decline from 2015. James Hansen et al (2013) have argued that 1ºC is the danger limit. Taking into account committed global warming, its millennial duration, multiple large sources of amplifying climate feedbacks and multiple adverse impacts of global warming and climate change on crops, and population health impacts, all the IPCC AR5 scenarios carry extreme environmental health risks to large human populations and to the future of humanity as a whole. Our risk consideration finds that 2ºC carries high risks of many catastrophic impacts, that 1.5ºC carries high risks of many disastrous impacts, and that 1ºC is the danger limit. IPCC AR4 (2007) showed that emissions must be reversed by 2015 for a 2ºC warming limit. For the IPCC AR5 only the best-case scenario RCP2.6, is projected to stay under 2ºC by 2100 but the upper range is just above 2ºC. It calls for emissions to decline by 2020. We recommend that for catastrophic environmental health risk aversion, emissions decline

  5. Risk managment of complex aquifers contaminated by chemical mixtures : numerical tools and human health risk assessment

    OpenAIRE

    Henri, Christopher

    2015-01-01

    Human impact on groundwater resources has led to a rapid growth of social concerns worldwide owing to an increasing presence of toxic chemicals released in the subsurface. Risk assessment provides the scientific tool needed to quantify the actual thread that these potential hazards pose to human health. Specifically, risk analysis enables decision makers to answer: What can happen? How likely is it to happen? What can be the consequences? Risk assessment is in this context essential. However,...

  6. Assessment of mercury health risks to adults from coal combustion

    Energy Technology Data Exchange (ETDEWEB)

    Lipfert, F.W.; Moskowitz, P.D.; Fthenakis, V.M.; DePhillips, M.P.; Viren, J.; Saroff, L.

    1994-05-01

    The U.S. Environmental Protection Agency (EPA) is preparing, for the U.S. Congress, a report evaluating the need to regulate mercury (Hg) emissions from electric utilities. This study, to be completed in 1995, will have important health and economic implications. In support of these efforts, the U.S. Department of Energy, Office of Fossil Energy, sponsored a risk assessment project at Brookhaven National Laboratory (BNL) to evaluate methylmercury (MeHg) hazards independently. In the BNL study, health risks to adults resulting from Hg emissions from a hypothetical 1000 MW{sub e} coal-fired power plant were estimated using probabilistic risk assessment techniques. The approach draws on the extant knowledge in each of the important steps in the calculation chain from emissions to health effects. Estimated results at key points in the chain were compared with actual measurements to help validate the modeled estimates. Two cases were considered: the baseline case (no local impacts), and the impact case (maximum local power-plant impact). The BNL study showed that the effects of emissions of a single power plant may double the background exposures to MeHg resulting from consuming fish obtained from a localized area near the power plant. Many implicit and explicit sources of uncertainty exist in this analysis. Those that appear to be most in need of improvement include data on doses and responses for potentially sensitive subpopulations (e.g., fetal exposures). Rather than considering hypothetical situations, it would also be preferable to assess the risks associated with actual coal-fired power plants and the nearby sensitive water bodies and susceptible subpopulations. Finally, annual total Hg emissions from coal burning and from other anthropogenic sources are still uncertain; this makes it difficult to estimate the effects of U.S. coal burning on global Hg concentration levels, especially over the long term.

  7. Risk assessment of genetically modified crops for nutrition and health.

    Science.gov (United States)

    Magaña-Gómez, Javier A; de la Barca, Ana M Calderón

    2009-01-01

    The risk assessment of genetically modified (GM) crops for human nutrition and health has not been systematic. Evaluations for each GM crop or trait have been conducted using different feeding periods, animal models, and parameters. The most common result is that GM and conventional sources induce similar nutritional performance and growth in animals. However, adverse microscopic and molecular effects of some GM foods in different organs or tissues have been reported. Diversity among the methods and results of the risk assessments reflects the complexity of the subject. While there are currently no standardized methods to evaluate the safety of GM foods, attempts towards harmonization are on the way. More scientific effort is necessary in order to build confidence in the evaluation and acceptance of GM foods.

  8. Relationships Between Animal Health Monitoring and the Risk Assessment Process

    Directory of Open Access Journals (Sweden)

    Salman MD

    2001-03-01

    Full Text Available Risk assessment is part of the risk analysis process as it is used in veterinary medicine to estimate risks related to international trade and food safety. Data from monitoring and surveillance systems (MO&SS are used throughout the risk assessment process for hazard identification, release assessment, exposure assessment and consequence assessment. As the quality of risk assessments depends to a large extent on the availability and quality of input data, there is a close relationship between MO&SS and risk assessment. In order to improve the quality of risk assessments, MO&SS should be designed according to minimum quality standards. Second, recent scientific developments on state-of-the-art design and analysis of surveys need to be translated into field applications and legislation. Finally, knowledge about the risk assessment process among MO&SS planners and managers should be promoted in order to assure high-quality data.

  9. Advanced korean industrial safety and health policy with risk assessment.

    Science.gov (United States)

    Kwon, Hyuckmyun; Cho, Jae Hyun; Moon, Il; Choi, Jaewook; Park, Dooyong; Lee, Youngsoon

    2010-09-01

    This article describes a systematic roadmap master plan for advanced industrial safety and health policy in Korea, with an emphasis on. Since Korean industries had first emergence of industrial safety and health policy in 1953, enormous efforts have been made on upgrading the relevant laws in order to reflect real situation of industrial work environment in accordance with rapid changes of Korean and global business over three decades. Nevertheless, current policy has major defects; too much techniques-based articles, diverged contents in less organization, combined enforcement and punishments and finally enforcing regulations full of commands and control. These deficiencies have make it difficult to accommodate changes of social, industrial and employment environment in customized fashion. The approach to the solution must be generic at the level of paradigm-shift rather than local modifications and enhancement. The basic idea is to establish a new system integrated with a risk assessment scheme, which encourages employers to apply to their work environment under comprehensive responsibility. The risk assessment scheme is designed to enable to inspect employers' compliances afterwards. A project comprises four yearly phases based on applying zones; initially designating and operating a specified risk zone, gradually expanding the special zones during a period of 3 years (2010-2012) and the final zone expanded to entire nation. In each phase, the intermediate version of the system is updated through a process of precise and unbiased validation in terms of its operability, feasibility and sustainability with building relevant infrastructures as needed.

  10. Environmental Health and Aging: Activity, Exposure and Biological Models to Improve Risk Assessment and Health Promotion

    Science.gov (United States)

    The US Environmental Protection Agency (EPA) and other public health agencies are concerned that the environmental health of America’s growing population of older adults has not been taken into consideration in current approaches to risk assessment. The reduced capacity to respo...

  11. Body burdens: an integrated approach to health risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Gasper, J. R.; Dauzvardis, P. A.

    1979-01-01

    Monitoring, modeling, and laboratory data are being integrated with physiological data in order to assess the impact of the release of environmental contaminants on the human receptor. The methodology described in this paper is intended primarily for use as a screening method to identify relative health risks. Comparison of body burdens and critical organ burdens can identify the relative contribution from different sources of exposure, exposure pathways, and routes of entry. These two burdens may be used in conjunction with monitoring data and environmental modeling techniques to assess the relative risk of effluent releases from natural and industrial sources or from different effluent control technologies or waste disposal methods. The relative impact of different levels of regional economic growth or regulatory plans can also be assessed. Body burdens may also serve to indicate where effluent control efforts will be most successful in reducing impacts on humans. The example projects the relative contributions to body burdens of arsenic, cadmium, chromium, mercury and lead resulting from background air and water quality, effluent releases from a coal-fired steam electric power plant, and from diet.

  12. ARIES: System for Health effects Assessment in industrial risk

    Energy Technology Data Exchange (ETDEWEB)

    Rabago, I.; Vidania, R. de; Inmaculada, S.

    1992-07-01

    . (Application lo Industrial Risk for Health Effects Assessment) (Author)

  13. Risk management assessment of Health Maintenance Organisations participating in the National Health Insurance Scheme

    Science.gov (United States)

    Campbell, Princess Christina; Korie, Patrick Chukwuemeka; Nnaji, Feziechukwu Collins

    2014-01-01

    Background: The National Health Insurance Scheme (NHIS), operated majorly in Nigeria by health maintenance organisations (HMOs), took off formally in June 2005. In view of the inherent risks in the operation of any social health insurance, it is necessary to efficiently manage these risks for sustainability of the scheme. Consequently the risk-management strategies deployed by HMOs need regular assessment. This study assessed the risk management in the Nigeria social health insurance scheme among HMOs. Materials and Methods: Cross-sectional survey of 33 HMOs participating in the NHIS. Results: Utilisation of standard risk-management strategies by the HMOs was 11 (52.6%). The other risk-management strategies not utilised in the NHIS 10 (47.4%) were risk equalisation and reinsurance. As high as 11 (52.4%) of participating HMOs had a weak enrollee base (less than 30,000 and poor monthly premium and these impacted negatively on the HMOs such that a large percentage 12 (54.1%) were unable to meet up with their financial obligations. Most of the HMOs 15 (71.4%) participated in the Millennium development goal (MDG) maternal and child health insurance programme. Conclusions: Weak enrollee base and poor monthly premium predisposed the HMOs to financial risk which impacted negatively on the overall performance in service delivery in the NHIS, further worsened by the non-utilisation of risk equalisation and reinsurance as risk-management strategies in the NHIS. There is need to make the scheme compulsory and introduce risk equalisation and reinsurance. PMID:25298605

  14. Risk management assessment of Health Maintenance Organisations participating in the National Health Insurance Scheme

    Directory of Open Access Journals (Sweden)

    Princess Christina Campbell

    2014-01-01

    Full Text Available Background: The National Health Insurance Scheme (NHIS, operated majorly in Nigeria by health maintenance organisations (HMOs, took off formally in June 2005. In view of the inherent risks in the operation of any social health insurance, it is necessary to efficiently manage these risks for sustainability of the scheme. Consequently the risk-management strategies deployed by HMOs need regular assessment. This study assessed the risk management in the Nigeria social health insurance scheme among HMOs. Materials and Methods: Cross-sectional survey of 33 HMOs participating in the NHIS. Results: Utilisation of standard risk-management strategies by the HMOs was 11 (52.6%. The other risk-management strategies not utilised in the NHIS 10 (47.4% were risk equalisation and reinsurance. As high as 11 (52.4% of participating HMOs had a weak enrollee base (less than 30,000 and poor monthly premium and these impacted negatively on the HMOs such that a large percentage 12 (54.1% were unable to meet up with their financial obligations. Most of the HMOs 15 (71.4% participated in the Millennium development goal (MDG maternal and child health insurance programme. Conclusions: Weak enrollee base and poor monthly premium predisposed the HMOs to financial risk which impacted negatively on the overall performance in service delivery in the NHIS, further worsened by the non-utilisation of risk equalisation and reinsurance as risk-management strategies in the NHIS. There is need to make the scheme compulsory and introduce risk equalisation and reinsurance.

  15. Health risk assessment for chemical exposures of military interest

    NARCIS (Netherlands)

    Langenberg, J.P.; Polhuijs, M.; Sijbranda, T.

    2016-01-01

    Participation in military operations is accompanied by health hazards resulting from exposure to chemical substances from natural and anthropogenic sources. Historically, focus on toxicological risks has been on the health effects of exposure to chemical warfare agents (CW A). In recent years the aw

  16. Information resources used in health risk assessment by the New Jersey Department of Environmental Protection

    Energy Technology Data Exchange (ETDEWEB)

    Post, G.B.; Baratta, M.; Wolfson, S.; McGeorge, L. [New Jersey Department of Environmental Protection, Trenton (United States)

    1990-12-31

    The New Jersey Department of Environmental Protection`s responsibilities related to health-based risk assessment are described, including its research projects and its development of health based compound specific standards and guidance levels. The resources used by the agency to support health risk assessment work are outlined.

  17. Aluminium: Food-related health risk assessment of the consumers

    Directory of Open Access Journals (Sweden)

    О.V. Bagryantseva

    2016-03-01

    Full Text Available Aluminum is the most abundant metal in the lithosphere, constituting 8 % of the earth's crust. Aluminum enters the food from the various objects of environment such as water, food contact materials (packaging materials, cooking vessels, aluminum-containing food additives. In raw food products the content of aluminum is less than 5.7 mg/kg of the product. Normally, aluminum is not practically found in a human body. However, within the last decade various toxic effects of aluminum on human body have been revealed, and they are able to cause the risk of various diseases. The analysis of the available data has demonstrated that the excessive entry of aluminum in human body with food items is associated first of all with the content of aluminum-containing food additives, as well as with the use of materials and products made of aluminum and its alloys intended for contact with food. High level of aluminum consumption has been also detected among children of all ages. At the same time, today, theprovisional tolerable weekly intake (PTWI of aluminum for children is not established. To reduce negative effect of aluminum on human body it is necessary to: * exclude from the list of Annex 2 of the Technical Regulations of the Customs Union "Requirements for Food Additives, Flavorings and Technological Aids” (TR TS 029/2012 the following food additives – potassium aluminum silicate (E555, bentonite (E558, sodium aluminum silicate (E554, potassium aluminum silicate (E555, calcium aluminum silicate (E556, aluminum silicate (kaolin (E559; * to develop requirements for the aluminum content in food products intended for children nutrition; * to obtain data on aluminum content in food items sold on the domestic market and to assess health risks to consumers.

  18. What Risk Assessments of Genetically Modified Organisms Can Learn from Institutional Analyses of Public Health Risks

    Directory of Open Access Journals (Sweden)

    S. Ravi Rajan

    2012-01-01

    Full Text Available The risks of genetically modified organisms (GMOs are evaluated traditionally by combining hazard identification and exposure estimates to provide decision support for regulatory agencies. We question the utility of the classical risk paradigm and discuss its evolution in GMO risk assessment. First, we consider the problem of uncertainty, by comparing risk assessment for environmental toxins in the public health domain with genetically modified organisms in the environment; we use the specific comparison of an insecticide to a transgenic, insecticidal food crop. Next, we examine normal accident theory (NAT as a heuristic to consider runaway effects of GMOs, such as negative community level consequences of gene flow from transgenic, insecticidal crops. These examples illustrate how risk assessments are made more complex and contentious by both their inherent uncertainty and the inevitability of failure beyond expectation in complex systems. We emphasize the value of conducting decision-support research, embracing uncertainty, increasing transparency, and building interdisciplinary institutions that can address the complex interactions between ecosystems and society. In particular, we argue against black boxing risk analysis, and for a program to educate policy makers about uncertainty and complexity, so that eventually, decision making is not the burden that falls upon scientists but is assumed by the public at large.

  19. What risk assessments of genetically modified organisms can learn from institutional analyses of public health risks.

    Science.gov (United States)

    Rajan, S Ravi; Letourneau, Deborah K

    2012-01-01

    The risks of genetically modified organisms (GMOs) are evaluated traditionally by combining hazard identification and exposure estimates to provide decision support for regulatory agencies. We question the utility of the classical risk paradigm and discuss its evolution in GMO risk assessment. First, we consider the problem of uncertainty, by comparing risk assessment for environmental toxins in the public health domain with genetically modified organisms in the environment; we use the specific comparison of an insecticide to a transgenic, insecticidal food crop. Next, we examine normal accident theory (NAT) as a heuristic to consider runaway effects of GMOs, such as negative community level consequences of gene flow from transgenic, insecticidal crops. These examples illustrate how risk assessments are made more complex and contentious by both their inherent uncertainty and the inevitability of failure beyond expectation in complex systems. We emphasize the value of conducting decision-support research, embracing uncertainty, increasing transparency, and building interdisciplinary institutions that can address the complex interactions between ecosystems and society. In particular, we argue against black boxing risk analysis, and for a program to educate policy makers about uncertainty and complexity, so that eventually, decision making is not the burden that falls upon scientists but is assumed by the public at large.

  20. Environmental Health Risk Assessment and Countermeasures on a Fire Extinguisher

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.K.; Jeong, D.W. [Korea Environment Institute, Seoul (Korea)

    2001-12-01

    Brominated flame retardants encompass a large number of different organic compounds sharing the common feature of containing bromine, which has an inhibitory effect on the development of fire. The substances are added to plastic materials, insulation foam, and other materials so as to enable the products to comply with fire safety requirements and wishes. The most problematic groups of compounds are polybrominated biphenyls(PBBs) and polybrominated diphenyl ethers(PBDEs). The objective of this project is to develop a management strategy for all problematic brominated flame retardants. A number of studies have shown that several of the brominated flame retardants occur in increasing concentrations in nature and in human beings. This is of concern because certain of the brominated flame retardants are suspected of having undesirable effects on the environment and health. The substances are generally very stable, especially so in the case of PBBs and PBDEs. These are strong reasons for hastening the phase-out of PBBs and PBDEs as group. Moreover, PBBs and PBDEs have attracted international attention. Within the OECD, business organisations have made voluntary agreements concerning PBBs and PBDEs. Rules of the EU forbid the use of PBBs in textiles coming into contact with the skin. The environmental and health risks of PBDEs are currently being evaluated as a part of an EU programme for existing substances. In Germany, PBBs and PBDEs are restricted through the Dioxin Ordinance and voluntary agreements with industry. Brominated flame retardants encompass a large number of different organic compounds sharing the common feature of containing bromine, which has an inhibitory effect on the development of fire. The substances are added to plastic materials, insulation foam, and other materials so as to enable the products to comply with fire safety requirements and wishes. The most problematic groups of compounds are polybrominated biphenyls(PBBs) and polybrominated diphenyl

  1. Environmental Health Risk Assessment and Countermeasures on a Fire Extinguisher

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.K.; Jeong, D.W. [Korea Environment Institute, Seoul (Korea)

    2001-12-01

    Brominated flame retardants encompass a large number of different organic compounds sharing the common feature of containing bromine, which has an inhibitory effect on the development of fire. The substances are added to plastic materials, insulation foam, and other materials so as to enable the products to comply with fire safety requirements and wishes. The most problematic groups of compounds are polybrominated biphenyls(PBBs) and polybrominated diphenyl ethers(PBDEs). The objective of this project is to develop a management strategy for all problematic brominated flame retardants. A number of studies have shown that several of the brominated flame retardants occur in increasing concentrations in nature and in human beings. This is of concern because certain of the brominated flame retardants are suspected of having undesirable effects on the environment and health. The substances are generally very stable, especially so in the case of PBBs and PBDEs. These are strong reasons for hastening the phase-out of PBBs and PBDEs as group. Moreover, PBBs and PBDEs have attracted international attention. Within the OECD, business organisations have made voluntary agreements concerning PBBs and PBDEs. Rules of the EU forbid the use of PBBs in textiles coming into contact with the skin. The environmental and health risks of PBDEs are currently being evaluated as a part of an EU programme for existing substances. In Germany, PBBs and PBDEs are restricted through the Dioxin Ordinance and voluntary agreements with industry. Brominated flame retardants encompass a large number of different organic compounds sharing the common feature of containing bromine, which has an inhibitory effect on the development of fire. The substances are added to plastic materials, insulation foam, and other materials so as to enable the products to comply with fire safety requirements and wishes. The most problematic groups of compounds are polybrominated biphenyls(PBBs) and polybrominated diphenyl

  2. 76 FR 52945 - Chlorpyrifos Registration Review; Preliminary Human Health Risk Assessment; Extension of Comment...

    Science.gov (United States)

    2011-08-24

    ... AGENCY Chlorpyrifos Registration Review; Preliminary Human Health Risk Assessment; Extension of Comment... availability of the chlorpyrifos registration review; preliminary human health risk assessment. This document extends the comment period for 30 days, from Tuesday, September 6, 2011 to Thursday, October 6,...

  3. Proposals for enhanced health risk assessment and stratification in an integrated care scenario

    Science.gov (United States)

    Dueñas-Espín, Ivan; Vela, Emili; Pauws, Steffen; Bescos, Cristina; Cano, Isaac; Cleries, Montserrat; Contel, Joan Carles; de Manuel Keenoy, Esteban; Garcia-Aymerich, Judith; Gomez-Cabrero, David; Kaye, Rachelle; Lahr, Maarten M H; Lluch-Ariet, Magí; Moharra, Montserrat; Monterde, David; Mora, Joana; Nalin, Marco; Pavlickova, Andrea; Piera, Jordi; Ponce, Sara; Santaeugenia, Sebastià; Schonenberg, Helen; Störk, Stefan; Tegner, Jesper; Velickovski, Filip; Westerteicher, Christoph; Roca, Josep

    2016-01-01

    Objectives Population-based health risk assessment and stratification are considered highly relevant for large-scale implementation of integrated care by facilitating services design and case identification. The principal objective of the study was to analyse five health-risk assessment strategies and health indicators used in the five regions participating in the Advancing Care Coordination and Telehealth Deployment (ACT) programme (http://www.act-programme.eu). The second purpose was to elaborate on strategies toward enhanced health risk predictive modelling in the clinical scenario. Settings The five ACT regions: Scotland (UK), Basque Country (ES), Catalonia (ES), Lombardy (I) and Groningen (NL). Participants Responsible teams for regional data management in the five ACT regions. Primary and secondary outcome measures We characterised and compared risk assessment strategies among ACT regions by analysing operational health risk predictive modelling tools for population-based stratification, as well as available health indicators at regional level. The analysis of the risk assessment tool deployed in Catalonia in 2015 (GMAs, Adjusted Morbidity Groups) was used as a basis to propose how population-based analytics could contribute to clinical risk prediction. Results There was consensus on the need for a population health approach to generate health risk predictive modelling. However, this strategy was fully in place only in two ACT regions: Basque Country and Catalonia. We found marked differences among regions in health risk predictive modelling tools and health indicators, and identified key factors constraining their comparability. The research proposes means to overcome current limitations and the use of population-based health risk prediction for enhanced clinical risk assessment. Conclusions The results indicate the need for further efforts to improve both comparability and flexibility of current population-based health risk predictive modelling approaches

  4. [The operational role of the occupational health physician in the assessment and management of health risks related to night risks].

    Science.gov (United States)

    Mucci, Nicola; Giorgi, Gabriele; Gonnelli, Irene Margherita; Garbarino, Sergio; Cupelli, Vincenzo; Arcangelil, Giulio

    2016-01-01

    The operational role of the occupational health physician in the assessment and management of health risks related to night work. Night work, in the last 30-40 years, has been extended to almost all areas of employment. The potential effects on workers' health--related to the disruption of circadian rhythms--are now well defined and studied in the Literature. All issues about the protection of safety and health for night workers are governed by the Italian Legislative Decree no. 66/2003 and subsequent amendments. The management of night work hasn't been included into the main Law on Occupational Safety and Health (Italian Legislative Decree no. 81/2008 and subsequent amendments) and a coordination between the two disciplines is desirable. The occupational health physician, as a global consultant for the protection of all health issues into a company, has to evaluate the potential effects of night work on health, both individually and as a group of workers. In this way, the physician may use either traditional tools (history, physical examination, blood tests) or innovative tools (questionnaires, health promotion programs, interventions on shift schedules). In the management of night work is useful to employ schedules that respect both psychophysical integrity and social welfare of workers and the needs of the production. The occupational health physician plays a significant role in information and training of workers, both individually and as a group of workers, and in the organization of health promotion programs (whit a voluntary participation by the workers).

  5. Assessing adaptation to the health risks of climate change: what guidance can existing frameworks provide?

    Science.gov (United States)

    Füssel, Hans-Martin

    2008-02-01

    Climate change adaptation assessments aim at assisting policy-makers in reducing the health risks associated with climate change and variability. This paper identifies key characteristics of the climate-health relationship and of the adaptation decision problem that require consideration in climate change adaptation assessments. It then analyzes whether these characteristics are appropriately considered in existing guidelines for climate impact and adaptation assessment and in pertinent conceptual models from environmental epidemiology. The review finds three assessment guidelines based on a generalized risk management framework to be most useful for guiding adaptation assessments of human health. Since none of them adequately addresses all key challenges of the adaptation decision problem, actual adaptation assessments need to combine elements from different guidelines. Established conceptual models from environmental epidemiology are found to be of limited relevance for assessing and planning adaptation to climate change since the prevailing toxicological model of environmental health is not applicable to many climate-sensitive health risks.

  6. Bridging the gap between academic research and regulatory health risk assessment of Endocrine Disrupting Chemicals.

    Science.gov (United States)

    Beronius, Anna; Hanberg, Annika; Zilliacus, Johanna; Rudén, Christina

    2014-12-01

    Regulatory risk assessment is traditionally based primarily on toxicity studies conducted according to standardized and internationally validated test guidelines. However, health risk assessment of endocrine disrupting chemicals (EDCs) is argued to rely on the efficient integration of findings from academic research. The aim of this review was to provide an overview of current developments to facilitate the use of academic research in regulatory risk assessment of chemicals and how certain aspects of study design and reporting are particularly important for the risk assessment process. By bridging the gap between academic research and regulatory health risk assessment of EDCs, scientific uncertainty in risk assessment conclusions can be reduced, allowing for better targeted policy decisions for chemical risk reduction.

  7. Proposals for enhanced health risk assessment and stratification in an integrated care scenario

    OpenAIRE

    Dueñas-Espín, Ivan; Vela, Emili; Pauws, Steffen; Bescos, Cristina; Cano, Isaac; Cleries, Montserrat; Contel, Joan Carles; de Manuel Keenoy, Esteban; Garcia-Aymerich, Judith; Gomez-Cabrero, David; Kaye, Rachelle; Lahr, Maarten M H; Lluch-Ariet, Magí; Moharra, Montserrat; Monterde, David

    2016-01-01

    Objectives: Population-based health risk assessment and stratification are considered highly relevant for large-scale implementation of integrated care by facilitating services design and case identification. The principal objective of the study was to analyse five health-risk assessment strategies and health indicators used in the five regions participating in the Advancing Care Coordination and Telehealth Deployment (ACT) programme (http://www.act-programme.eu). The second purpose was to el...

  8. SAFETY ANALYSIS AND RISK ASSESSMENT FOR BRIDGES HEALTH MONITORING WITH MONTE CARLO METHODS

    OpenAIRE

    2016-01-01

    With the increasing requirements of building safety in the past few decades, healthy monitoring and risk assessment of structures is of more and more importance. Especially since traffic loads are heavier, risk Assessment for bridges are essential. In this paper we take advantage of Monte Carlo Methods to analysis the safety of bridge and monitoring the destructive risk. One main goal of health monitoring is to reduce the risk of unexpected damage of artificial objects

  9. Quantitative approaches for health risk assessment of environmental pollutants : estimation of differences in sensitivity, relative potencies, and margins of exposure

    OpenAIRE

    Kalantari, Fereshteh

    2012-01-01

    Historically, quantitative health risk assessment of chemical substances is based on deterministic approaches. For a more realistic and informative health risk assessment, however, the variability and uncertainty inherent in measurements should be taken into consideration. The variability and uncertainty may be assessed by applying probabilistic methods when performing dose-response assessment, exposure assessment and risk characterization. The benchmark dose (BMD) method has b...

  10. [Health Risk Assessment of Drinking Water Quality in Tianjin Based on GIS].

    Science.gov (United States)

    Fu, Gang; Zeng, Qiang; Zhao, Liang; Zhang, Yue; Feng, Bao-jia; Wang, Rui; Zhang, Lei; Wang, Yang; Hou, Chang-chun

    2015-12-01

    This study intends to assess the potential health hazards of drinking water quality and explore the application of geographic information system( GIS) in drinking water safety in Tianjin. Eight hundred and fifty water samples from 401 sampling points in Tianjin were measured according to the national drinking water standards. The risk assessment was conducted using the environmental health risk assessment model recommended by US EAP, and GIS was combined to explore the information visualization and risk factors simultaneously. The results showed that the health risks of carcinogens, non-carcinogens were 3.83 x 10⁻⁵, 5.62 x 10⁻⁹ and 3.83 x 10⁻⁵ for total health risk respectively. The rank of health risk was carcinogen > non-carcinogen. The rank of carcinogens health risk was urban > new area > rural area, chromium (VI) > cadmium > arsenic > trichlormethane > carbon tetrachloride. The rank of non-carcinogens health risk was rural area > new area > urban, fluoride > cyanide > lead > nitrate. The total health risk level of drinking water in Tianjin was lower than that of ICRP recommended level (5.0 x 10⁻⁵), while was between US EPA recommended level (1.0 x 10⁻⁴-1.0 x 10⁻⁶). It was at an acceptable level and would not cause obvious health hazards. The main health risks of drinking water came from carcinogens. More attentions should be paid to chromium (VI) for carcinogens and fluoride for non-carcinogens. GIS can accomplish information visualization of drinking water risk assessment and further explore of risk factors.

  11. Waste area Grouping 2 Phase I task data report: Human health risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Purucker, S.T.; Douthat, D.M.

    1996-06-01

    This report is one of five reports issued in 1996 that provide follow- up information to the Phase 1 Remedial Investigation (RI) Report for Waste Area Grouping (WAG) 2 at Oak Ridge National Laboratory (ORNL). The five reports address areas of concern that could cause potential human health risk and ecological risk within WAG2 at ORNL. The purpose of this report is to present a summary of the human health risk assessment results based on the data collected for the WAG 2 Phase 1 RI. Estimates of risk are provided based on measured concentrations in the surface water, floodplain soil, and sediment of White Oak Creek, Melton Branch, and their tributaries. The human health risk assessment methodology used in this risk assessment is based on Risk Assessment Guidance for Superfund (RAGS). First, the data for the different media are elevated to determine usability for risk assessment. Second, through the process of selecting chemicals of potential concern (COPCs), contaminants to be considered in the risk assessment are identified for each assessment of exposure potential is performed, and exposure pathways are identified. Subsequently, exposure is estimated quantitatively, and the toxicity of each of the COPCs is determined. The results of these analyses are combined and summarized in a risk characterization.

  12. [Future built-up area zoning by applying the methodology for assessing the population health risk].

    Science.gov (United States)

    Bobkova, T E

    2009-01-01

    Using the methodology for assessing the population health risk provides proposals on the functional zoning of the reorganized area of a plastics-works. An area has been allocated for possible house-building.

  13. Health benefits of 'grow your own' food in urban areas: implications for contaminated land risk assessment and risk management?

    LENUS (Irish Health Repository)

    2009-12-21

    Abstract Compelling evidence of major health benefits of fruit and vegetable consumption, physical activity, and outdoor interaction with \\'greenspace\\' have emerged in the past decade - all of which combine to give major potential health benefits from \\'grow-your-own\\' (GYO) in urban areas. However, neither current risk assessment models nor risk management strategies for GYO in allotments and gardens give any consideration to these health benefits, despite their potential often to more than fully compensate the risks. Although urban environments are more contaminated by heavy metals, arsenic, polyaromatic hydrocarbons and dioxins than most rural agricultural areas, evidence is lacking for adverse health outcomes of GYO in UK urban areas. Rarely do pollutants in GYO food exceed statutory limits set for commercial food, and few people obtain the majority of their food from GYO. In the UK, soil contamination thresholds triggering closure or remediation of allotment and garden sites are based on precautionary principles, generating \\'scares\\' that may negatively impact public health disproportionately to the actual health risks of exposure to toxins through own-grown food. By contrast, the health benefits of GYO are a direct counterpoint to the escalating public health crisis of \\'obesity and sloth\\' caused by eating an excess of saturated fats, inadequate consumption of fresh fruit and vegetables combined with a lack of exercise. These are now amongst the most important preventable causes of illness and death. The health and wider societal benefits of \\'grow-your-own\\' thus reveal a major limitation in current risk assessment methodologies which, in only considering risks, are unable to predict whether GYO on particular sites will, overall, have positive, negative, or no net effects on human health. This highlights a more general need for a new generation of risk assessment tools that also predict overall consequences for health to more effectively guide

  14. Public health risk assessment of groundwater contamination in Batman, Turkey.

    Science.gov (United States)

    Nalbantcilar, M Tahir; Pinarkara, Sukru Yavuz

    2016-08-01

    In this study, a comprehensive analysis of groundwater was performed to assess contamination and phenol content in Batman, Turkey, particularly in residential areas near agriculture, livestock and oil industry facilities. From these areas, where potentially contaminated groundwater used for drinking and irrigation threatens public health, 30 groundwater samples were collected and analyzed for heavy metal concentrations (Al, As, B, Ba, Ca, Cd, Cl, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn, Mo, Na, Ni, NO3, P, Pb, phenol, S, Sb, Se, SO4, Sr, U, and Zn). Compared with the standards of the Environmental Protection Agency, Al, Fe, and Mn concentrations in groundwater exceeded secondary drinking water regulations, NO3 concentrations were high for maximum contaminant levels, and As, Pb, and U concentrations exceeded maximum contaminant level goals in all samples. Ni, Sb, and Se concentrations also exceeded limits set by the Turkish Standards Institution. Nearly all samples revealed concentrations of Se, Sb, Hg, and phenol due to nearby petroleum refineries, oil storage plants, and agricultural and livestock areas. The results obtained from this study indicate that the groundwater in Batman contains elements in concentrations that approach or exceed limits and thus threatens public health with increased blood cholesterol, decreased blood sugar, and circulatory problems.

  15. Health risk assessment standards of cyanobacteria bloom occurrence in bathing sites

    Directory of Open Access Journals (Sweden)

    Agnieszka Stankiewicz

    2011-03-01

    Full Text Available Threat for human health appears during a massive cyanobacteria bloom in potable water used for human consumption or in basins used for recreational purposes. General health risk assessment standards and preventive measures to be taken by sanitation service were presented in scope of: – evaluation of cyanobacteria bloom occurrence in bathing sites / water bodies, – procedures in case of cyanobacteria bloom, including health risk assessment and decision making process to protect users’ health at bathing sites, – preventive measures, to be taken in case of cyanobacteria bloom occurrence in bathing sites and basins, where bathing sites are located.

  16. Assessing Heat Health Risk for Sustainability in Beijing’s Urban Heat Island

    Directory of Open Access Journals (Sweden)

    Weihua Dong

    2014-10-01

    Full Text Available This research is motivated by the increasing threat of urban heat waves that are likely worsened by pervasive global warming and urbanization. Different regions of the city including urban, borderland and rural area will experience different levels of heat health risk. In this paper, we propose an improved approach to quantitatively assess Beijing’s heat health risk based on three factors from hazard, vulnerability and especially environment which is considered as an independent factor because different land use/cover types have different influence on ambient air temperatures under the Urban Heat Island effect. The results show that the heat health risk of Beijing demonstrates a spatial-temporal pattern with higher risk in the urban area, lower risk in the borderland between urban and rural area, and lowest risk in the rural area, and the total risk fluctuated dramatically during 2008–2011. To be more specific, the heat health risk was clearly higher in 2009 and 2010 than in 2008 and 2011. Further analysis with the urban area at sub-district level signifies that the impervious surface (urban area such as buildings, roads, et al. ratio is of high correlation with the heat health risk. The validation results show that the proposed method improved the accuracy of heat health risk assessment. We recommend that policy makers should develop efficient urban planning to accomplish Beijing’s sustainable development.

  17. An instrument for broadened risk assessment in antenatal health care including non-medical issues

    OpenAIRE

    Amber Amanda Vos; Mieke J van Veen; Erwin Birnie; Semiha Denktas; Eric AP Steegers; Bonsel, Gouke J

    2015-01-01

    Introduction: Growing evidence on the risk contributing role of non-medical factors on pregnancy outcomes urged for a new approach in early antenatal risk selection. The evidence invites to more integration, in particular between the clinical working area and the public health domain. We developed a non-invasive, standardized instrument for comprehensive antenatal risk assessment. The current study presents the application-oriented development of a risk screening instrument for early antenata...

  18. The impact of behavioral and mental health risk assessments on goal setting in primary care.

    Science.gov (United States)

    Krist, Alex H; Glasgow, Russell E; Heurtin-Roberts, Suzanne; Sabo, Roy T; Roby, Dylan H; Gorin, Sherri N Sheinfeld; Balasubramanian, Bijal A; Estabrooks, Paul A; Ory, Marcia G; Glenn, Beth A; Phillips, Siobhan M; Kessler, Rodger; Johnson, Sallie Beth; Rohweder, Catherine L; Fernandez, Maria E

    2016-06-01

    Patient-centered health risk assessments (HRAs) that screen for unhealthy behaviors, prioritize concerns, and provide feedback may improve counseling, goal setting, and health. To evaluate the effectiveness of routinely administering a patient-centered HRA, My Own Health Report, for diet, exercise, smoking, alcohol, drug use, stress, depression, anxiety, and sleep, 18 primary care practices were randomized to ask patients to complete My Own Health Report (MOHR) before an office visit (intervention) or continue usual care (control). Intervention practice patients were more likely than control practice patients to be asked about each of eight risks (range of differences 5.3-15.8 %, p set goals for six risks (range of differences 3.8-16.6 %, p controls, intervention patients felt clinicians cared more for them and showed more interest in their concerns. Patient-centered health risk assessments improve screening and goal setting.Trial RegistrationClinicaltrials.gov identifier: NCT01825746.

  19. Indicators for Environment Health Risk Assessment in the Jiangsu Province of China

    Directory of Open Access Journals (Sweden)

    Shujie Zhang

    2015-09-01

    Full Text Available According to the framework of “Pressure-State-Response”, this study established an indicator system which can reflect comprehensive risk of environment and health for an area at large scale. This indicator system includes 17 specific indicators covering social and economic development, pollution emission intensity, air pollution exposure, population vulnerability, living standards, medical and public health, culture and education. A corresponding weight was given to each indicator through Analytical Hierarchy Process (AHP method. Comprehensive risk assessment of the environment and health of 58 counties was conducted in the Jiangsu province, China, and the assessment result was divided into four types according to risk level. Higher-risk counties are all located in the economically developed southern region of Jiangsu province and relatively high-risk counties are located along the Yangtze River and Xuzhou County and its surrounding areas. The spatial distribution of relatively low-risk counties is dispersive, and lower-risk counties mainly located in the middle region where the economy is somewhat weaker in the province. The assessment results provide reasonable and scientific basis for Jiangsu province Government in formulating environment and health policy. Moreover, it also provides a method reference for the comprehensive risk assessment of environment and health within a large area (provinces, regions and countries.

  20. Public Health and Epidemiological Considerations For Avian Influenza Risk Mapping and Risk Assessment

    Directory of Open Access Journals (Sweden)

    Joseph P. Dudley

    2008-12-01

    Full Text Available Avian influenza viruses are now widely recognized as important threats to agricultural biosecurity and public health, and as the potential source for pandemic human influenza viruses. Human infections with avian influenza viruses have been reported from Asia (H5N1, H5N2, H9N2, Africa (H5N1, H10N7, Europe (H7N7, H7N3, H7N2, and North America (H7N3, H7N2, H11N9. Direct and indirect public health risks from avian influenzas are not restricted to the highly pathogenic H5N1 "bird flu" virus, and include low pathogenic as well as high pathogenic strains of other avian influenza virus subtypes, e.g., H1N1, H7N2, H7N3, H7N7, and H9N2. Research has shown that the 1918 Spanish Flu pandemic was caused by an H1N1 influenza virus of avian origins, and during the past decade, fatal human disease and human-to-human transmission has been confirmed among persons infected with H5N1 and H7N7 avian influenza viruses. Our ability to accurately assess and map the potential economic and public health risks associated with avian influenza outbreaks is currently constrained by uncertainties regarding key aspects of the ecology and epidemiology of avian influenza viruses in birds and humans, and the mechanisms by which highly pathogenic avian influenza viruses are transmitted between and among wild birds, domestic poultry, mammals, and humans. Key factors needing further investigation from a risk management perspective include identification of the driving forces behind the emergence and persistence of highly pathogenic avian influenza viruses within poultry populations, and a comprehensive understanding of the mechanisms regulating transmission of highly pathogenic avian influenza viruses between industrial poultry farms and backyard poultry flocks. More information is needed regarding the extent to which migratory bird populations to contribute to the transnational and transcontinental spread of highly pathogenic avian influenza viruses, and the potential for wild bird

  1. There is more to risk and safety planning than dramatic risks: Mental health nurses' risk assessment and safety-management practice.

    Science.gov (United States)

    Higgins, Agnes; Doyle, Louise; Downes, Carmel; Morrissey, Jean; Costello, Paul; Brennan, Michael; Nash, Michael

    2016-04-01

    Risk assessment and safety planning are considered a cornerstone of mental health practice, yet limited research exists into how mental health nurses conceptualize 'risk' and how they engage with risk assessment and safety planning. The aim of the present study was to explore mental health nurses' practices and confidence in risk assessment and safety planning. A self-completed survey was administered to 381 mental health nurses in Ireland. The findings indicate that nurses focus on risk to self and risk to others, with the risk of suicide, self-harm, substance abuse, and violence being most frequently assessed. Risk from others and 'iatrogenic' risk were less frequently considered. Overall, there was limited evidence of recovery-oriented practice in relation to risk. The results demonstrate a lack of meaningful engagement with respect to collaborative safety planning, the identification and inclusion of protective factors, and the inclusion of positive risk-taking opportunities. In addition, respondents report a lack of confidence working with positive risk taking and involving family/carers in the risk-assessment and safety-planning process. Gaps in knowledge about risk-assessment and safety-planning practice, which could be addressed through education, are identified, as are the implications of the findings for practice and research.

  2. Health Risk Assessment of Inhalable Particulate Matter in Beijing Based on the Thermal Environment

    Directory of Open Access Journals (Sweden)

    Lin-Yu Xu

    2014-11-01

    Full Text Available Inhalable particulate matter (PM10 is a primary air pollutant closely related to public health, and an especially serious problem in urban areas. The urban heat island (UHI effect has made the urban PM10 pollution situation more complex and severe. In this study, we established a health risk assessment system utilizing an epidemiological method taking the thermal environment effects into consideration. We utilized a remote sensing method to retrieve the PM10 concentration, UHI, Normalized Difference Vegetation Index (NDVI, and Normalized Difference Water Index (NDWI. With the correlation between difference vegetation index (DVI and PM10 concentration, we utilized the established model between PM10 and thermal environmental indicators to evaluate the PM10 health risks based on the epidemiological study. Additionally, with the regulation of UHI, NDVI and NDWI, we aimed at regulating the PM10 health risks and thermal environment simultaneously. This study attempted to accomplish concurrent thermal environment regulation and elimination of PM10 health risks through control of UHI intensity. The results indicate that urban Beijing has a higher PM10 health risk than rural areas; PM10 health risk based on the thermal environment is 1.145, which is similar to the health risk calculated (1.144 from the PM10 concentration inversion; according to the regulation results, regulation of UHI and NDVI is effective and helpful for mitigation of PM10 health risk in functional zones.

  3. Risk assessment

    DEFF Research Database (Denmark)

    Pedersen, Liselotte; Rasmussen, Kirsten; Elsass, Peter

    2010-01-01

    ). All patients were assessed for risk of future violence utilizing a structured professional judgment model: the Historical-Clinical-Risk Management-20 (HCR-20) violence risk assessment scheme. After a follow-up period of 5.6 years, recidivism outcome were obtained from the Danish National Crime...... predictive of violent recidivism compared to static items. In sum, the findings support the use of structured professional judgment models of risk assessment and in particular the HCR-20 violence risk assessment scheme. Findings regarding the importance of the (clinical) structured final risk judgment......International research suggests that using formalized risk assessment methods may improve the predictive validity of professionals' predictions of risk of future violence. This study presents data on forensic psychiatric patients discharged from a forensic unit in Denmark in year 2001-2002 (n=107...

  4. Effects on cardiovascular disease risk of a web-based health risk assessment with tailored health advice: A follow-up study

    NARCIS (Netherlands)

    E.B. Colkesen (Ersen); B.S. Ferket (Bart); J.G.P. Tijssen (Jan); R.A. Kraaijenhagen (Roderik); C.K. Kalken (Coenraad); R.J. Peters (Ron)

    2011-01-01

    textabstractIntroduction: A large proportion of the cardiovascular disease (CVD) burden can potentially be prevented by primary prevention programs addressing major causal risk factors. A Web- based health risk assessment (HRA) with tailored feedback for individual health promotion is a promising st

  5. Analysis of family health history based risk assessment algorithms: classification and data requirements.

    Science.gov (United States)

    Ranade-Kharkar, Pallavi; Del Fiol, Guilherme; Williams, Janet L; Hulse, Nathan C; Haug, Peter

    2013-01-01

    Family Health History (FHH) is a valuable and potentially low-cost tool for risk assessment and diagnosis in patient-centered healthcare. In this study, we identified and analyzed existing FHH-based risk assessment algorithms (RAAs) for cardio-vascular disease (CVD) and colorectal cancer (CRC) to guide implementers of electronic health record (EHR) systems regarding the data requirements for computing risk using these algorithms. We found a core set of data elements that are required by most RAAs. While some of these data are available in EHR systems, the patients can be empowered to contribute the remainder.

  6. [The application of two occupation health risk assessment models in a wooden furniture manufacturing industry].

    Science.gov (United States)

    Wang, A H; Leng, P B; Bian, G L; Li, X H; Mao, G C; Zhang, M B

    2016-10-20

    Objective: To explore the applicability of 2 different models of occupational health risk assessment in wooden furniture manufacturing industry. Methods: American EPA inhalation risk model and ICMM model of occupational health risk assessment were conducted to assess occupational health risk in a small wooden furniture enterprises, respectively. Results: There was poor protective measure and equipment of occupational disease in the plant. The concentration of wood dust in the air of two workshops was over occupational exposure limit (OEL) , and the CTWA was 8.9 mg/m(3) and 3.6 mg/m(3), respectively. According to EPA model, the workers who exposed to benzene in this plant had high risk (9.7×10(-6) ~34.3×10(-6)) of leukemia, and who exposed to formaldehyde had high risk (11.4 × 10(-6)) of squamous cell carcinoma. There were inconsistent evaluation results using the ICMM tools of standard-based matrix and calculated risk rating. There were very high risks to be attacked by rhinocarcinoma of the workers who exposed to wood dust for the tool of calculated risk rating, while high risk for the tool of standard-based matrix. For the workers who exposed to noise, risk of noise-induced deafness was unacceptable and medium risk using two tools, respectively. Conclusion: Both EPA model and ICMM model can appropriately predict and assessthe occupational health risk in wooden furniture manufactory, ICMM due to the relatively simple operation, easy evaluation parameters, assessment of occupational- disease-inductive factors comprehensively, and more suitable for wooden furniture production enterprise.

  7. Risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Gittus, J.H.

    1986-03-01

    The article deals with the calculation of risks, as applied to living near to a) a nuclear reactor or b) an industrial complex. The application of risk assessment techniques to the pressurised water reactor (PWR) is discussed with respect to: containment, frequencies of degraded core accidents, release of radioisotopes, consequences and risk to society, and uncertainties. The risk assessment for an industrial complex concerns the work of the Safety and Reliability Directorate for the chemical complex on Canvey Island. (U.K.).

  8. Determinants of participation in a web-based health risk assessment and consequences for health promotion programs

    NARCIS (Netherlands)

    M.A.J. Niessen (Maurice); E.L. Laan (Eva); S.J.W. Robroek (Suzan); M.L.E. Essink-Bot (Marie-Louise); N. Peek (Niels); R.A. Kraaijenhagen (Roderik); C.K. van Kalken (Coen); A. Burdorf (Alex)

    2013-01-01

    textabstractBackground: The health risk assessment (HRA) is a type of health promotion program frequently offered at the workplace. Insight into the underlying determinants of participation is needed to evaluate and implement these interventions. Objective: To analyze whether individual characterist

  9. Thoracic and respirable particle definitions for human health risk assessment

    Science.gov (United States)

    Provides estimates of the thoracic and respirable fractions, for adults and children during typical activities during both nasal and oral inhalation, that may be used in the design of experimental studies and interpretation of evidence of health effects.

  10. Air pollution epidemiology. Assessment of health effects and risks

    Energy Technology Data Exchange (ETDEWEB)

    Katsouyanni, K. [Athens Univ. (Greece). Dept. of Hygiene and Epidemiology

    1995-12-31

    Air pollution epidemiology is the study of the occurrence and distribution of health outcomes in association with community air pollution exposure. It is therefore specific in the exposure variable. Air pollution health effects became evident during high air pollution episodes which occurred in the first decades of our century. Since then, legal and other control measures have led to lower air pollution levels. However, recent results from several studies indicate that lower levels of air pollution than the previously considered safe have serious adverse health effects. Although, there is increasingly agreement that air pollution, at levels measured today, affects health, there is still a lot to be understood concerning specific causal pollutants, biologic mechanisms involved and sensitive groups of individuals. The extent of potential confounding, time-considerations in air pollution effects, individual variation in air pollution exposure and exposure misclassification are some factors which complicate the study of these issues. (author)

  11. Energy Drinks: An Assessment of the Potential Health Risks in the Canadian Context

    OpenAIRE

    Rotstein, Joel; Barber, Jennifer; Strowbridge, Carl; Hayward, Stephen; Huang, Rong; Godefroy, Samuel Benrejeb

    2013-01-01

    The purpose of this document is to develop a health risk assessment on energy drinks, based on health hazard and exposure assessments when consumed as a food in Canada. In this document, a typical energy drink is exemplified by the product known as Red Bull, where a single can serving of 250 ml contains 80 mg of caffeine, 1000 mg of taurine, 600 mg of glucuronolactone and several B vitamins. Health hazard data on energy drinks were found to be limited and therefore the hazard assessment w...

  12. Molecular biomarkers to assess health risks due to environmental contaminants exposure.

    Science.gov (United States)

    Poblete-Naredo, Irais; Albores, Arnulfo

    2016-06-03

    Biomarkers, or bioindicators, are metric tools that, when compared with reference values, allow specialists to perform risk assessments and provide objective information to decision makers to design effective strategies to solve health or environmental problems by efficiently using the resources assigned. Health risk assessment is a multidisciplinary exercise, and molecular biology is a discipline that greatly contributes to these evaluations because the genome, transcriptome, proteome and metabolome could be affected by xenobiotics causing measurable changes that might be useful biomarkers. Such changes may greatly depend on individual genetic background; therefore, the polymorphic distribution of exposed populations becomes an essential feature for adequate data interpretation. The aim of this paper is to offer an up-to-date review of the role of different molecular biomarkers in health risk assessments.

  13. Human health risk assessment: selected Internet and world wide web resources.

    Science.gov (United States)

    Patterson, Jacqueline; Hakkinen, P J Bert; Wullenweber, Andrea E

    2002-04-25

    The world wide web (WWW) has become a valuable source of 24 hour-a-day access to information needed by human health risk assessors. Various web sites and other Internet resources provide information needed for human hazard identification, dose-response evaluation, exposure assessment, risk characterization, and risk management. Information on risk communication is also available. Substantial collections of information on multiple aspects of risk assessment are found in sites sponsored by RiskWorld, the (US) EPA's National Center for Environmental Assessment (NCEA), the (US) National Library of Medicine's TOXNET, the (US) Agency for Toxic Substances and Disease Registry (ATSDR), and the International Programme on Chemical Safety (IPCS). Also valuable are various web sites providing information on the physical and chemical properties of chemicals, the environmental fate and transport of chemicals, government regulations, and guidance and training for performing risk assessments. Several professional societies and other organizations have web sites addressing risk assessment issues and information, and there are Internet mailing lists for online help and for sharing information and perspectives. We classify selected web sites according to user needs and provide the reader with a collection of selected sites that can serve as entry points to risk assessment-related web resources.

  14. U.S. Department of Energy worker health risk evaluation methodology for assessing risks associated with environmental restoration and waste management

    Energy Technology Data Exchange (ETDEWEB)

    Blaylock, B.P.; Legg, J.; Travis, C.C. [Oak Ridge National Lab., TN (United States). Center for Risk Management; Simek, M.A.; Sutherland, J. [Univ. of Tennessee, Knoxville, TN (United States); Scofield, P.A. [Office of Environmental Compliance and Documentation (United States)

    1995-06-01

    This document describes a worker health risk evaluation methodology for assessing risks associated with Environmental Restoration (ER) and Waste Management (WM). The methodology is appropriate for estimating worker risks across the Department of Energy (DOE) Complex at both programmatic and site-specific levels. This document supports the worker health risk methodology used to perform the human health risk assessment portion of the DOE Programmatic Environmental Impact Statement (PEIS) although it has applications beyond the PEIS, such as installation-wide worker risk assessments, screening-level assessments, and site-specific assessments.

  15. Review of various approaches for assessing public health risks in regulatory decision making: choosing the right approach for the problem.

    Science.gov (United States)

    Dearfield, Kerry L; Hoelzer, Karin; Kause, Janell R

    2014-08-01

    Stakeholders in the public health risk analysis community can possess differing opinions about what is meant by "conduct a risk assessment." In reality, there is no one-size-fits-all risk assessment that can address all public health issues, problems, and regulatory needs. Although several international and national organizations (e.g., Codex Alimentarius Commission, Office International des Epizooties, Food and Agricultural Organization, World Health Organization, National Research Council, and European Food Safety Authority) have addressed this issue, confusion remains. The type and complexity of a risk assessment must reflect the risk management needs to appropriately inform a regulatory or nonregulatory decision, i.e., a risk assessment is ideally "fit for purpose" and directly applicable to risk management issues of concern. Frequently however, there is a lack of understanding by those not completely familiar with risk assessment regarding the specific utility of different approaches for assessing public health risks. This unfamiliarity can unduly hamper the acceptance of risk assessment results by risk managers and may reduce the usefulness of such results for guiding public health policies, practices, and operations. Differences in interpretation of risk assessment terminology further complicate effective communication among risk assessors, risk managers, and stakeholders. This article provides an overview of the types of risk assessments commonly conducted, with examples primarily from the food and agricultural sectors, and a discussion of the utility and limitations of these specific approaches for assessing public health risks. Clarification of the risk management issues and corresponding risk assessment design needs during the formative stages of the risk analysis process is a key step for ensuring that the most appropriate assessment of risk is developed and used to guide risk management decisions.

  16. Health risk assessment of jobs involving ionizing radiation sources

    Directory of Open Access Journals (Sweden)

    Spasojević-Tišma Vera D.

    2011-01-01

    Full Text Available The study included 75 subjects exposed to low doses of external ionizing radiation and 25 subjects from the control group, all male. The first group (A consisted of 25 subjects employed in the production of technetium, with an average job experience of 15 years. The second group (B consisted of 25 subjects exposed to ionizing radiation from enclosed sources, working in jobs involving the control of X-ray devices and americium smoke detectors, their average work experience being 18.5 years. The third group (C consisted of 25 subjects involved in the decontamination of the terrain at Borovac from radioactive rounds with depleted uranium left over after the NATO bombing of Serbia in 1999, their average job experience being 18.5 years. The control group (K consisted of 25 subjects who have not been in contact with sources of ionizing radiation and who hold administrative positions. Frequencies of chromosome aberrations were determined in lymphocytes of peripheral blood and compared to the control group. The average annual absorbed dose determined by thermoluminescent dosimeters for all three groups did not exceed 2 mSv. In the present study, the largest number of observed changes are acentric fragments and chromosome breaks. The highest occupational risk appears to involve subjects working in manufacturing of the radio-isotope technetium.

  17. Exploring the relationship between criminogenic risk assessment and mental health court program completion.

    Science.gov (United States)

    Bonfine, Natalie; Ritter, Christian; Munetz, Mark R

    2016-01-01

    The two primary goals of mental health courts are to engage individuals with severe mental illness in the criminal justice system with clinical mental health services and to prevent future involvement with the criminal justice system. An important factor in helping to achieve both goals is to identify participants' level of clinical needs and criminogenic risk/needs. This study seeks to better understand how criminogenic risk affects outcomes in a mental health court. Specifically, we explore if high criminogenic risk is associated with failure to complete mental health court. Our subjects are participants of a municipal mental health court (MHC) who completed the Level of Services Inventory-Revised (LSI-R) upon entry to the program (N=146). We used binary logistic regression to determine the association between termination from the program with the total LSI-R. Our findings suggest that, net of prior criminal history, time in the program and clinical services received, high criminogenic risk/need is associated with failure to complete mental health court. In addition to providing clinical services, our findings suggest the need for MHCs to include criminogenic risk assessment to identify criminogenic risk. For participants to succeed in MHCs, both their clinical and criminogenic needs should be addressed.

  18. A probabilistic assessment of health risks associated with short-term exposure to tropospheric ozone

    Energy Technology Data Exchange (ETDEWEB)

    Whitfield, R.G; Biller, W.F.; Jusko, M.J.; Keisler, J.M.

    1996-06-01

    The work described in this report is part of a larger risk assessment sponsored by the U.S. Environmental Protection Agency. Earlier efforts developed exposure-response relationships for acute health effects among populations engaged in heavy exertion. Those efforts also developed a probabilistic national ambient air quality standards exposure model and a general methodology for integrating probabilistic exposure-response relation- ships and exposure estimates to calculate overall risk results. Recently published data make it possible to model additional health endpoints (for exposure at moderate exertion), including hospital admissions. New air quality and exposure estimates for alternative national ambient air quality standards for ozone are combined with exposure-response models to produce the risk results for hospital admissions and acute health effects. Sample results explain the methodology and introduce risk output formats.

  19. Health Risk-Based Assessment and Management of Heavy Metals-Contaminated Soil Sites in Taiwan

    Directory of Open Access Journals (Sweden)

    Zueng-Sang Chen

    2010-10-01

    Full Text Available Risk-based assessment is a way to evaluate the potential hazards of contaminated sites and is based on considering linkages between pollution sources, pathways, and receptors. These linkages can be broken by source reduction, pathway management, and modifying exposure of the receptors. In Taiwan, the Soil and Groundwater Pollution Remediation Act (SGWPR Act uses one target regulation to evaluate the contamination status of soil and groundwater pollution. More than 600 sites contaminated with heavy metals (HMs have been remediated and the costs of this process are always high. Besides using soil remediation techniques to remove contaminants from these sites, the selection of possible remediation methods to obtain rapid risk reduction is permissible and of increasing interest. This paper discusses previous soil remediation techniques applied to different sites in Taiwan and also clarified the differences of risk assessment before and after soil remediation obtained by applying different risk assessment models. This paper also includes many case studies on: (1 food safety risk assessment for brown rice growing in a HMs-contaminated site; (2 a tiered approach to health risk assessment for a contaminated site; (3 risk assessment for phytoremediation techniques applied in HMs-contaminated sites; and (4 soil remediation cost analysis for contaminated sites in Taiwan.

  20. Health Risk-Based Assessment and Management of Heavy Metals-Contaminated Soil Sites in Taiwan

    Science.gov (United States)

    Lai, Hung-Yu; Hseu, Zeng-Yei; Chen, Ting-Chien; Chen, Bo-Ching; Guo, Horng-Yuh; Chen, Zueng-Sang

    2010-01-01

    Risk-based assessment is a way to evaluate the potential hazards of contaminated sites and is based on considering linkages between pollution sources, pathways, and receptors. These linkages can be broken by source reduction, pathway management, and modifying exposure of the receptors. In Taiwan, the Soil and Groundwater Pollution Remediation Act (SGWPR Act) uses one target regulation to evaluate the contamination status of soil and groundwater pollution. More than 600 sites contaminated with heavy metals (HMs) have been remediated and the costs of this process are always high. Besides using soil remediation techniques to remove contaminants from these sites, the selection of possible remediation methods to obtain rapid risk reduction is permissible and of increasing interest. This paper discusses previous soil remediation techniques applied to different sites in Taiwan and also clarified the differences of risk assessment before and after soil remediation obtained by applying different risk assessment models. This paper also includes many case studies on: (1) food safety risk assessment for brown rice growing in a HMs-contaminated site; (2) a tiered approach to health risk assessment for a contaminated site; (3) risk assessment for phytoremediation techniques applied in HMs-contaminated sites; and (4) soil remediation cost analysis for contaminated sites in Taiwan. PMID:21139851

  1. Integration of quantitative risk assessment in the health impact assessment of the recently amended Hungarian anti-smoking policy

    DEFF Research Database (Denmark)

    Ádám, Balázs; Molnár, Ágnes; Gulis, Gabriel

    2011-01-01

    . In the frame of the Risk Assessment from Policy to Impact Dimension EU project, quantitative assessment of several health outcomes has been integrated in the HIA of the recently prepared anti-smoking policy of Hungary, which had the primary goal of protecting non-smokers from environmental tobacco smoke...... experiences, while outcome assessment calculated measures of disease burden, like attributable death and disability adjusted life years, for a baseline and a predicted situation after the proposed changes take place. The major impact of the proposal was identified to decreases prevalence of active and passive...... population of Hungary. As demonstrated by the results, providing smoke-free public places has an unambiguous positive impact on the health of the public that has been confirmed by the quantified health gain. The demonstrated methodology offers a practicable example for applying quantitative risk assessment...

  2. A Risk Assessment Matrix for Public Health Principles: The Case for E-Cigarettes.

    Science.gov (United States)

    Saitta, Daniela; Chowdhury, Azim; Ferro, Giancarlo Antonio; Nalis, Federico Giuseppe; Polosa, Riccardo

    2017-03-31

    Besides nicotine replacement therapies, a realistic alternative for smoking cessation or for smoking substitution may come from electronic cigarettes (ECs), whose popularity has been steadily growing. As for any emerging behaviour associated with exposure to inhalational agents, there is legitimate cause for concern and many health organizations and policy makers have pushed for restrictive policy measures ranging from complete bans to tight regulations of these products. Nonetheless, it is important to reframe these concerns in context of the well-known harm caused by cigarette smoking. In this article, we discuss key public health principles that should be considered when regulating ECs. These include the concept of tobacco harm reduction, importance of relative risk and risk continuum, renormalization of smoking, availability of low-risk product, proportionate taxation, and reassessment of the role of non-tobacco flavours. These public health principles may be systematically scrutinized using a risk assessment matrix that allows: (1) to determine the measure of certainty that a risk will occur; and (2) to estimate the impact of such a risk on public health. Consequently, the ultimate goal of responsible ECs regulation should be that of maximizing the favourable impact of these reduced-risk products whilst minimizing further any potential risks. Consumer perspectives, sound EC research, continuous post-marketing surveillance and reasonable safety and quality product standards should be at the very heart of future regulatory schemes that will address concerns while minimizing unintended consequences of ill-informed regulation.

  3. Factsheets for the (eco)toxicological risk assessment strategy of the National Institute of Public Health and the Environment (RIVM)

    NARCIS (Netherlands)

    Luttik R; Raaij MTM van; CSR

    2001-01-01

    Eight fact sheets describing risk assessment methods used at the Centre of Substances and Risk assessment (CSR) of the National Institute for Public Health and the Environment (RIVM) are presented here with the main aim of promoting greater transparency in the risk assessment methods used at the Ins

  4. Integrated Environmental Health Impact Assessment for Risk Governance Purposes; Across What Do We Integrate?

    NARCIS (Netherlands)

    Lebret, Erik

    2016-01-01

    Integrated Environmental Health Impact Assessment (IEHIA) can be considered as an element in the third phase of environmental risk management. Its focus is on providing inclusive descriptions of multiple impacts from multiple stressors in such a way that they can be evaluated against the potential s

  5. Human health risk assessment (HHRA) for environmental development and transfer of antibiotic resistance

    Science.gov (United States)

    Objective: Here we present possible approaches and identify research needs to enable human health risk assessments that focus on the role the environment plays in antibiotic treatment failure of patients. Methods: The authors participated in a workshop sub-committee to define t...

  6. Acrylamide in Romanian food using HPLC-UV and a health risk assessment.

    Science.gov (United States)

    Oroian, Mircea; Amariei, Sonia; Gutt, Gheorghe

    2015-01-01

    The aim of this study was to investigate the level of acrylamide from coffee, potato chips and French fries in Romanian food. According to the European Food Safety Authority, coffee beans, potato chips and French fries have the highest levels of acrylamide. For this survey, 50 samples of coffee beans, 50 samples of potato chips and 25 samples of French fries were purchased from different producers from the Romanian market. Acrylamide levels have been quantified using high-performance liquid chromatography with a diode array detector (HPLC-DAD) method, using water as mobile phase. Health risk assessment was achieved by computing the average daily intake, hazard quotient, cumulative risk, carcinogenic risk and cancer risk. For coffee, potato chips and French fries, acrylamide was not shown to pose a health risk in Romanian food.

  7. Health risk assessment linked to filling coastal quarries with treated dredged seaport sediments

    Energy Technology Data Exchange (ETDEWEB)

    Perrodin, Yves, E-mail: yves.perrodin@entpe.fr [Université de Lyon, ENTPE, UMR CNRS 5023, Laboratoire LEHNA, 2 rue Maurice Audin, 69518 Vaulx-en-Velin (France); Donguy, Gilles [Université de Lyon, ENTPE, UMR CNRS 5023, Laboratoire LEHNA, 2 rue Maurice Audin, 69518 Vaulx-en-Velin (France); Emmanuel, Evens [Laboratoire de Qualité de l' Eau et de l' Environnement, Université Quisqueya, BP 796 Port-au-Prince (Haiti); Winiarski, Thierry [Université de Lyon, ENTPE, UMR CNRS 5023, Laboratoire LEHNA, 2 rue Maurice Audin, 69518 Vaulx-en-Velin (France)

    2014-07-01

    Dredged seaport sediments raise complex management problems since it is no longer possible to discharge them into the sea. Traditional waste treatments are poorly adapted for these materials in terms of absorbable volumes and cost. In this context, filling quarries with treated sediments appears interesting but its safety regarding human health must be demonstrated. To achieve this, a specific methodology for assessing health risks has been developed and tested on three seaport sediments. This methodology includes the development of a conceptual model of the global scenario studied and the definition of specific protocols for each of its major steps. The approach proposed includes in particular the use of metrological and experimental tools that are new in this context: (i) an experimental lysimeter for characterizing the deposit emissions, and (ii) a geological radar for identifying potential preferential pathways between the sediment deposit and the groundwater. The application of this approach on the three sediments tested for the scenario studied showed the absence of health risk associated with the consumption of groundwater for substances having a “threshold effect” (risk quotient < 1), and an acceptable risk for substances having a “non-threshold effect”, with the notable exception of arsenic (individual risk equal to 3.10{sup −6}). - Highlights: • The release of polluted dredged seaport sediments into the sea must be avoided. • Their use after treatment for the filling-up of quarries is proposed by managers. • An original health risk assessment methodology was created to validate this option. • It includes the use of a lysimeter and a georadar for the exposure assessment stage. • The example studied concludes to a health risk linked to arsenic in the groundwater.

  8. Perceived Preparedness of Health Care Students for Providing Cardiovascular Disease Risk Assessment and Management

    Directory of Open Access Journals (Sweden)

    Monica Zolezzi

    2017-02-01

    Full Text Available Early assessment and management of risk factors is known to have significant impact in preventing cardiovascular disease (CVD and its associated burden. Cardiovascular disease risk assessment and management (CVDRAM is best approached by teamwork across health care professionals. This study aimed at assessing health care students’ (HCSs knowledge about the parameters needed for estimating CVD risk, their self-assessed preparedness/confidence and perceived barriers for the provision of CVDRAM services through a survey administered to third and fourth year pharmacy, medical, and nursing students in Qatar. Although all student cohorst achieved similar knowledge scores, less than half (n = 38, 47% were able to identify all of the six main risk factors necessary to estimate absolute CVD risk, and a third (32% were unable to identify total cholesterol as an independent risk factor necessary to estimate CVD risk. Training on the use of CVD risk assessment tools differed among the three student cohorts. All student cohorts also perceived similar levels of preparedness in CVDRAM. However, pharmacy students reported the highest preparedness/confidence with the use of the latest CVDRAM guidelines. The majority of statements listed under the barriers scale were perceived by the students as being moderate (median score = 3. Poor public acceptance or unawareness of importance of estimating CVD risk was the only barrier perceived as major by nursing students. Future integration of interprofessional educational (IPE activities in the CVDRAM curricula of HCSs may be a suitable strategy to minimize barriers and foster collaborative practice for the provision of CVDRAM services in Qatar.

  9. An instrument for broadened risk assessment in antenatal health care including non-medical issues

    Directory of Open Access Journals (Sweden)

    Amber Amanda Vos

    2015-03-01

    Full Text Available Introduction: Growing evidence on the risk contributing role of non-medical factors on pregnancy outcomes urged for a new approach in early antenatal risk selection. The evidence invites to more integration, in particular between the clinical working area and the public health domain. We developed a non-invasive, standardized instrument for comprehensive antenatal risk assessment. The current study presents the application-oriented development of a risk screening instrument for early antenatal detection of risk factors and tailored prevention in an integrated care setting.Methods: A review of published instruments complemented with evidence from cohort studies. Selection and standardization of risk factors associated with small for gestational age, preterm birth, congenital anomalies and perinatal mortality. Risk factors were weighted to obtain a cumulative risk score. Responses were then connected to corresponding care pathways. A cumulative risk threshold was defined, which can be adapted to the population and the availability of preventive facilities. A score above the threshold implies multidisciplinary consultation between caregivers.Results: The resulting digital score card consisted of 70 items, subdivided into four non-medical and two medical domains. Weighing of risk factors was based on existing evidence. Pilot-evidence from a cohort of 218 pregnancies in a multi-practice urban setting showed a cut-off of 16 points would imply 20% of all pregnant women to be assessed in a multidisciplinary setting. A total of 28 care pathways were defined.Conclusion: The resulting score card is a universal risk screening instrument which incorporates recent evidence on non-medical risk factors for adverse pregnancy outcomes and enables systematic risk management in an integrated antenatal health care setting.

  10. An instrument for broadened risk assessment in antenatal health care including non-medical issues

    Directory of Open Access Journals (Sweden)

    Amber Amanda Vos

    2015-03-01

    Full Text Available Introduction: Growing evidence on the risk contributing role of non-medical factors on pregnancy outcomes urged for a new approach in early antenatal risk selection. The evidence invites to more integration, in particular between the clinical working area and the public health domain. We developed a non-invasive, standardized instrument for comprehensive antenatal risk assessment. The current study presents the application-oriented development of a risk screening instrument for early antenatal detection of risk factors and tailored prevention in an integrated care setting. Methods: A review of published instruments complemented with evidence from cohort studies. Selection and standardization of risk factors associated with small for gestational age, preterm birth, congenital anomalies and perinatal mortality. Risk factors were weighted to obtain a cumulative risk score. Responses were then connected to corresponding care pathways. A cumulative risk threshold was defined, which can be adapted to the population and the availability of preventive facilities. A score above the threshold implies multidisciplinary consultation between caregivers. Results: The resulting digital score card consisted of 70 items, subdivided into four non-medical and two medical domains. Weighing of risk factors was based on existing evidence. Pilot-evidence from a cohort of 218 pregnancies in a multi-practice urban setting showed a cut-off of 16 points would imply 20% of all pregnant women to be assessed in a multidisciplinary setting. A total of 28 care pathways were defined. Conclusion: The resulting score card is a universal risk screening instrument which incorporates recent evidence on non-medical risk factors for adverse pregnancy outcomes and enables systematic risk management in an integrated antenatal health care setting.

  11. Human health risk assessment of potentially toxic elements (PTEs) from environmental matrices

    OpenAIRE

    Elom, Nwabueze

    2012-01-01

    In assessing human health risk of potentially toxic elements (PTEs), it is not the concentration of PTEs in the environmental matrices that is of greatest concern but the fraction that is absorbed into the body via the exposure pathways. The determination of this fraction (i.e. the bioaccessible fraction) through the application of bioaccessibility protocols is the focus of this work. The study investigated human health risk of PTEs (As, Cd, Cr, Cu, Pb, Mn, Ni and Zn) from oral ingestion of s...

  12. Volatile compounds emission and health risk assessment during composting of organic fraction of municipal solid waste

    DEFF Research Database (Denmark)

    Mustafa, Muhammad Farooq; Liu, Yanjun; Duan, Zhenhan;

    2017-01-01

    Degradation of mechanically sorted organic fraction (MSOF) of municipal solid waste in composting facilities is among the major contributors of volatile compounds (VCs) generation and emission, causes nuisance problems and health risks on site as well as in the vicinages. The aim of current study...... was to determine the seasonal (summer and winter) variation and human health risk assessment of VCs in the ambient air of different processing units in MSOF at composting plant in China. Average concentration of VCs was 58.50 and 138.03 mg/m3 in summer and winter respectively. Oxygenated compounds were found...

  13. Pollution Characteristics and Health Risk Assessment of Airborne Heavy Metals Collected from Beijing Bus Stations.

    Science.gov (United States)

    Zheng, Xiaoxia; Zhao, Wenji; Yan, Xing; Shu, Tongtong; Xiong, Qiulin; Chen, Fantao

    2015-08-17

    Airborne dust, which contains high levels of toxic metals, is recognized as one of the most harmful environment component. The purpose of this study was to evaluate heavy metals pollution in dustfall from bus stations in Beijing, and to perform a risk assessment analysis for adult passengers. The concentrations of Cd, Co, Cr, Cu, Mo, Ni, Pb, V and Zn were determined by inductively coupled plasma mass spectroscopy (ICP-MS). The spatial distribution, pollution level and potential health risk of heavy metals were analyzed by Geographic Information System (GIS) mapping technology, geo-accumulation index and health risk assessment model, respectively. The results indicate that dust samples have elevated metal concentrations, especially for Cd, Cu, Pb and Zn. The nine metals can be divided into two categories in terms of spatial distribution and pollution level. Cd, Cr, Cu, Mo, Pb and Zn reach contaminated level and have similar spatial patterns with hotspots distributed within the Fifth Ring Road. While the hot spot areas of Co and V are always out of the Fifth Ring Road. Health risk assessment shows that both carcinogenic and non-carcinogenic risks of selected metals were within the safe range.

  14. GM Risk Assessment

    Science.gov (United States)

    Sparrow, Penny A. C.

    GM risk assessments play an important role in the decision-making process surrounding the regulation, notification and permission to handle Genetically Modified Organisms (GMOs). Ultimately the role of a GM risk assessment will be to ensure the safe handling and containment of the GMO; and to assess any potential impacts on the environment and human health. A risk assessment should answer all ‘what if’ scenarios, based on scientific evidence.

  15. A review of soil heavy metal pollution from mines in China: pollution and health risk assessment.

    Science.gov (United States)

    Li, Zhiyuan; Ma, Zongwei; van der Kuijp, Tsering Jan; Yuan, Zengwei; Huang, Lei

    2014-01-15

    Heavy metal pollution has pervaded many parts of the world, especially developing countries such as China. This review summarizes available data in the literature (2005-2012) on heavy metal polluted soils originating from mining areas in China. Based on these obtained data, this paper then evaluates the soil pollution levels of these collected mines and quantifies the risks these pollutants pose to human health. To assess these potential threat levels, the geoaccumulation index was applied, along with the US Environmental Protection Agency (USEPA) recommended method for health risk assessment. The results demonstrate not only the severity of heavy metal pollution from the examined mines, but also the high carcinogenic and non-carcinogenic risks that soil heavy metal pollution poses to the public, especially to children and those living in the vicinity of heavily polluted mining areas. In order to provide key management targets for relevant government agencies, based on the results of the pollution and health risk assessments, Cd, Pb, Cu, Zn, Hg, As, and Ni are selected as the priority control heavy metals; tungsten, manganese, lead-zinc, and antimony mines are selected as the priority control mine categories; and southern provinces and Liaoning province are selected as the priority control provinces. This review, therefore, provides a comprehensive assessment of soil heavy metal pollution derived from mines in China, while identifying policy recommendations for pollution mitigation and environmental management of these mines.

  16. Source apportionment and health risk assessment of trace metals in surface soils of Beijing metropolitan, China.

    Science.gov (United States)

    Chen, Haiyang; Teng, Yanguo; Lu, Sijin; Wang, Yeyao; Wu, Jin; Wang, Jinsheng

    2016-02-01

    Understanding the exposure risks of trace metals in contamination soils and apportioning their sources are the basic preconditions for soil pollution prevention and control. In this study, a detailed investigation was conducted to assess the health risks of trace metals in surface soils of Beijing which is one of the most populated cities in the world and to apportion their potential sources. The data set of metals for 12 elements in 240 soil samples was collected. Pollution index and enrichment factor were used to identify the general contamination characteristic of soil metals. The probabilistic risk model was employed for health risk assessment, and a chemometrics technique, multivariate curve resolution-weighted alternating least squares (MCR-WALS), was applied to apportion sources. Results suggested that the soils in Beijing metropolitan region were contaminated by Hg, Cd, Cu, As, and Pb in varying degree, lying in the moderate pollution level. As a whole, the health risks posed by soil metals were acceptable or close to tolerable. Comparatively speaking, children and adult females were the relatively vulnerable populations for the non-carcinogenic and carcinogenic risks, respectively. Atmospheric deposition, fertilizers and agrochemicals, and natural source were apportioned as the potential sources determining the contents of trace metals in soils of Beijing area with contributions of 15.5%-16.4%, 5.9%-7.7% and 76.0%-78.6%, respectively.

  17. Environmental health risk assessment of ambient lead levels in Lisbon, Portugal: A full chain study approach

    DEFF Research Database (Denmark)

    Casimiro, E.; Philippe Ciffroy, P.; Serpa, P.;

    2011-01-01

    The multi-causality interactions between environment and health are complex and call for an integrated multidisciplinary study approach. Emerging computational toxicology tools that link toxicology, chemistry, environmental sciences, biostatistics, and computer sciences are proving to be very...... useful for integrated full-chain human health risk assessments. In this study we use a newly developed computational tool – the 2FUN player to conduct a full-chain assessment combining measured ambient air lead concentrations with multi-media modelling and PBPK simulations to estimate the health risks...... from ambient air levels of lead in air-borne particulates (PM10) in Lisbon, Portugal. Ambient air Pb concentrations were used together with local climate variables in the 2FUN atmospheric model to calculate the amount of Pb deposited (wet and dry) onto soil. The 2FUN environmental and PBPK models were...

  18. A tiered assessment framework to evaluate human health risk of contaminated sediment.

    Science.gov (United States)

    Greenfield, Ben K; Melwani, Aroon R; Bay, Steven M

    2015-07-01

    For sediment contaminated with bioaccumulative pollutants (e.g., PCBs and organochorine pesticides), human consumption of seafood that contain bioaccumulated sediment-derived contaminants is a well-established exposure pathway. Historically, regulation and management of this bioaccumulation pathway has focused on site-specific risk assessment. The state of California (United States) is supporting the development of a consistent and quantitative sediment assessment framework to aid in interpreting a narrative objective to protect human health. The conceptual basis of this framework focuses on 2 key questions: 1) do observed pollutant concentrations in seafood from a given site pose unacceptable health risks to human consumers? and 2) is sediment contamination at a site a significant contributor to seafood contamination? The first question is evaluated by interpreting seafood tissue concentrations at the site, based on health risk calculations. The second question is evaluated by interpreting site-specific sediment chemistry data using a food web bioaccumulation model. The assessment framework includes 3 tiers (screening assessment, site assessment, and refined site assessment), which enables the assessment to match variations in data availability, site complexity, and study objectives. The second and third tiers use a stochastic simulation approach, incorporating information on variability and uncertainty of key parameters, such as seafood contaminant concentration and consumption rate by humans. The framework incorporates site-specific values for sensitive parameters and statewide values for difficult to obtain or less sensitive parameters. The proposed approach advances risk assessment policy by incorporating local data into a consistent region-wide problem formulation, applying best available science in a streamlined fashion.

  19. Effects on cardiovascular disease risk of a web-based health risk assessment with tailored health advice: a follow-up study

    Directory of Open Access Journals (Sweden)

    Colkesen

    2011-02-01

    Full Text Available Ersen B Colkesen1,2, Bart S Ferket2,3, Jan GP Tijssen1, Roderik A Kraaijenhagen2, Coenraad K van Kalken2, Ron JG Peters11Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; 2NDDO Institute for Prevention and Early Diagnostics (NIPED, Amsterdam, the Netherlands; 3Department of Epidemiology, Erasmus Medical Center, Rotterdam, the NetherlandsIntroduction: A large proportion of the cardiovascular disease (CVD burden can potentially be prevented by primary prevention programs addressing major causal risk factors. A Web-based health risk assessment (HRA with tailored feedback for individual health promotion is a promising strategy. We evaluated the effect on CVD risk of such a program among employees of a Dutch worksite.Methods: We conducted a prospective follow-up study among 368 employees who voluntarily participated in a Web-based HRA program at a single Dutch worksite in 2008. The program included a multicomponent HRA through a Web-based electronic questionnaire, biometrics, and laboratory evaluation. The results were combined with health behavior change theory to generate tailored motivational and educational health advice. On request, a health counseling session with the program physician was available. Follow-up data on CVD risk were collected 1 year after initial participation. The primary outcome was a change in Framingham CVD risk at 6 months relative to baseline. We checked for a possible background effect of an increased health consciousness as a consequence of program introduction at the worksite by comparing baseline measurements of early program participants with baseline measurements of participants who completed the program 6 months later.Results: A total of 176 employees completed follow-up measurements after a mean of 7 months. There was a graded relation between CVD risk changes and baseline risk, with a relative reduction of 17.9% (P = 0.001 in the high-risk category (baseline

  20. DALY-Based Health Risk Assessment of Construction Noise in Beijing, China.

    Science.gov (United States)

    Xiao, Jun; Li, Xiaodong; Zhang, Zhihui

    2016-10-26

    Noise produced by construction activities has become the second most serious acoustic polluting element in China. To provide industry practitioners with a better understanding of the health risks of construction noise and to aid in creating environmentally friendly construction plans during early construction stages, we developed a quantitative model to assess the health impairment risks (HIA) associated with construction noise for individuals living adjacent to construction sites. This model classifies noise-induced health impairments into four categories: cardiovascular disease, cognitive impairment, sleep disturbance, and annoyance, and uses disability-adjusted life years (DALYs) as an indicator of damage. Furthermore, the value of a statistical life (VSL) is used to transform DALYs into a monetary value based on the affected demographic characteristics, thereby offering policy makers a reliable theoretical foundation for establishing reasonable standards to compensate residents suffering from construction noise. A practical earthwork project in Beijing is used as a case study to demonstrate the applicability of the proposed model. The results indicate that construction noise could bring significant health risks to the neighboring resident community, with an estimated 34.51 DALYs of health damage and 20.47 million yuan in social costs. In particular, people aged 45-54 are most vulnerable to construction noise, with the greatest health risks being caused by sleep disturbance.

  1. Coronary artery disease risk assessment from unstructured electronic health records using text mining.

    Science.gov (United States)

    Jonnagaddala, Jitendra; Liaw, Siaw-Teng; Ray, Pradeep; Kumar, Manish; Chang, Nai-Wen; Dai, Hong-Jie

    2015-12-01

    Coronary artery disease (CAD) often leads to myocardial infarction, which may be fatal. Risk factors can be used to predict CAD, which may subsequently lead to prevention or early intervention. Patient data such as co-morbidities, medication history, social history and family history are required to determine the risk factors for a disease. However, risk factor data are usually embedded in unstructured clinical narratives if the data is not collected specifically for risk assessment purposes. Clinical text mining can be used to extract data related to risk factors from unstructured clinical notes. This study presents methods to extract Framingham risk factors from unstructured electronic health records using clinical text mining and to calculate 10-year coronary artery disease risk scores in a cohort of diabetic patients. We developed a rule-based system to extract risk factors: age, gender, total cholesterol, HDL-C, blood pressure, diabetes history and smoking history. The results showed that the output from the text mining system was reliable, but there was a significant amount of missing data to calculate the Framingham risk score. A systematic approach for understanding missing data was followed by implementation of imputation strategies. An analysis of the 10-year Framingham risk scores for coronary artery disease in this cohort has shown that the majority of the diabetic patients are at moderate risk of CAD.

  2. Risk Assessment of Physical Health Hazards in Al-Azhar University Hospital in New Damietta, Egypt

    Directory of Open Access Journals (Sweden)

    Mohammed El-Hady Imam*, Raed Mohammed Alazab**,

    2013-10-01

    Full Text Available Introduction: Personnel working in hospitals are exposed to many occupational hazards that may threaten their health and safety. Physical hazards that are encountered in hospital working environment include temperature, illumination, noise, electrical injuries, and radiation. Objectives: The objectives of this study were to identify physical health hazards in all departments of Al-Azhar University Hospital in new Damietta, to measure risk level of these hazards, and to recognize safety measures in these departments. Study Site: The study was conducted in Al-Azhar University Hospital in Damietta Governorate. Study Subjects: All personnel (328 working in the hospital were recruited. Study Methods: Interview forms; a workplace inspection checklist, assess physical health hazards in the hospital and a modified checklist (workplace safety and health risk management, assess leadership commitment towards workplace safety and health. Risk assessment matrix was used to describe the risk level. Also, environmental measurements of noise, temperature, relative humidity, and lighting were taken in all departments including auxiliary service offices. Results: Majority of the staffs reported stairways were free of obstacles, emergency lighting worked properly, and temperature was suitable. Minority of the staffs reported stairways were slippery, they were informed on hazards of noise and non-ionizing radiation, and they were given radiation safety training. Measurements of physical agents revealed noise levels were above standard of the WHO in all wards and above slandered of OSHA as in laundry, kitchen, etc. Range of noise level was from 58 dB in renal dialysis unit to 88 dB in kitchen. Lighting level was from 290 to 1150 Lux, temperature level was from 25 to 31°C, relative humidity level was from 45 to 59%, and heat index was low in all departments except kitchen and boiler room, it was moderate. Risk level of electrical and fire hazards was medium 22 (B

  3. Critical elements for human health risk assessment of less than lifetime exposures.

    Science.gov (United States)

    Geraets, Liesbeth; Nijkamp, Monique M; Ter Burg, Wouter

    2016-11-01

    Less than lifetime exposure has confronted risk assessors as to how to interpret the risks for human health in case a chronic health-based limit is exceeded. Intermittent, fluctuating and peak exposures do not match with the basis of the chronic limit values possibly leading to conservative outcomes. This paper presents guidance on how to deal with human risk assessment of less than lifetime exposure. Important steps to be considered are characterization of the human exposure situation, evaluation whether the human less than lifetime exposure scenario corresponds to a non-chronic internal exposure: toxicokinetic and toxicodynamic considerations, and, finally, re-evaluation of the risk assessment. Critical elements for these steps are the mode of action, Haber's rule, and toxicokinetics (ADME) amongst others. Previous work for the endpoints non-genotoxic carcinogenicity and developmental toxicity is included in the guidance. The guidance provides a way to consider the critical elements, without setting default factors to correct for the less than lifetime exposure in risk assessment.

  4. Human and animal health risk assessments of chemicals in the food chain: Comparative aspects and future perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Dorne, J.L.C.M., E-mail: jean-lou.dorne@efsa.europa.eu [Emerging Risk Unit, Via Carlo Magno 1A, 43126 Parma (Italy); Fink-Gremmels, J. [Utrecht University, Faculty of Veterinary Medicine, Institute for Risk Assessment Sciences, Yalelaan 104, 3584 CM Utrecht (Netherlands)

    2013-08-01

    Chemicals from anthropogenic and natural origins enter animal feed, human food and water either as undesirable contaminants or as part of the components of a diet. Over the last five decades, considerable efforts and progress to develop methodologies to protect humans and animals against potential risks associated with exposure to such potentially toxic chemicals have been made. This special issue presents relevant methodological developments and examples of risk assessments of undesirable substances in the food chain integrating the animal health and the human health perspective and refers to recent Opinions of the Scientific Panel on Contaminants in the Food Chain (CONTAM) of the European Food Safety Authority (EFSA). This introductory review aims to give a comparative account of the risk assessment steps used in human health and animal health risk assessments for chemicals in the food chain and provides a critical view of the data gaps and future perspectives for this cross-disciplinary field. - Highlights: ► Principles of human and animal health risk assessment. ► Data gaps for each step of animal health risk assessment. ► Implications of animal risk assessment on human risk assessment. ► Future perspectives on chemical risk assessment.

  5. Measuring compliance of conducting an occupational health risk assessment in the occupational health nurse’s practice

    Directory of Open Access Journals (Sweden)

    Nicolene de Jager

    2014-09-01

    Full Text Available Occupational health nurses (OHNs are qualified registered nurses with a postgraduate qualification in occupational health nursing. An important activity of OHNs is to identify and assess health risks in the workplace. Health risk assessments (HRAs are conducted by OHNs to determine all the occupational health stressors, for example noise, vibration and chemical substances. The authors conducted legal compliance occupational health audits and observed that 85% (n = 23 of OHNs in different settings conduct HRAs only to a limited extent. The following objective was formulated for the study: To explore and describe the extent to which OHNs conduct HRAs as it is a legal requirement for compliance; and the possible reasons for not adhering to the regulation and conduct them only to a limited extent. A quantitative, descriptive design was used in this study. A sampling frame was developed from a list of all the members of the South African Society of Occupational Health Nursing Practitioners (SASOHN in Gauteng. From the target population of OHNs in Gauteng, a systematic cluster sampling method was used. A self-developed questionnaire was distributed by mail and e-mail, and authors sent respondents reminders. The authors ensured that validity, reliability and ethical standards were adhered to. The findings revealed that OHNs are mature, experienced, predominately female practitioners who operate on behalf of a disproportionately large number of workers. Four factors influencing these nurses in conducting an HRA to a limited extent were identified: competence, ignorance about the role of the OHN, workload and attitude.

  6. Health risk assessment of organic micropollutants in greywater for potable reuse.

    Science.gov (United States)

    Etchepare, Ramiro; van der Hoek, Jan Peter

    2015-04-01

    In light of the increasing interest in development of sustainable potable reuse systems, additional research is needed to elucidate the risks of producing drinking water from new raw water sources. This article investigates the presence and potential health risks of organic micropollutants in greywater, a potential new source for potable water production introduced in this work. An extensive literature survey reveals that almost 280 organic micropollutants have been detected in greywater. A three-tiered approach is applied for the preliminary health risk assessment of these chemicals. Benchmark values are derived from established drinking water standards for compounds grouped in Tier 1, from literature toxicological data for compounds in Tier 2, and from a Threshold of Toxicological Concern approach for compounds in Tier 3. A risk quotient is estimated by comparing the maximum concentration levels reported in greywater to the benchmark values. The results show that for the majority of compounds, risk quotient values were below 0.2, which suggests they would not pose appreciable concern to human health over a lifetime exposure to potable water. Fourteen compounds were identified with risk quotients above 0.2 which may warrant further investigation if greywater is used as a source for potable reuse. The present findings are helpful in prioritizing upcoming greywater quality monitoring and defining the goals of multiple barriers treatment in future water reclamation plants for potable water production.

  7. Initiation of health-behaviour change among employees participating in a web-based health risk assessment with tailored feedback

    Directory of Open Access Journals (Sweden)

    Kraaijenhagen Roderik A

    2011-03-01

    Full Text Available Abstract Background Primary prevention programs at the worksite can improve employee health and reduce the burden of cardiovascular disease. Programs that include a web-based health risk assessment (HRA with tailored feedback hold the advantage of simultaneously increasing awareness of risk and enhancing initiation of health-behaviour change. In this study we evaluated initial health-behaviour change among employees who voluntarily participated in such a HRA program. Methods We conducted a questionnaire survey among 2289 employees who voluntarily participated in a HRA program at seven Dutch worksites between 2007 and 2009. The HRA included a web-based questionnaire, biometric measurements, laboratory evaluation, and tailored feedback. The survey questionnaire assessed initial self-reported health-behaviour change and satisfaction with the web-based HRA, and was e-mailed four weeks after employees completed the HRA. Results Response was received from 638 (28% employees. Of all, 86% rated the program as positive, 74% recommended it to others, and 58% reported to have initiated overall health-behaviour change. Compared with employees at low CVD risk, those at high risk more often reported to have increased physical activity (OR 3.36, 95% CI 1.52-7.45. Obese employees more frequently reported to have increased physical activity (OR 3.35, 95% CI 1.72-6.54 and improved diet (OR 3.38, 95% CI 1.50-7.60. Being satisfied with the HRA program in general was associated with more frequent self-reported initiation of overall health-behaviour change (OR 2.77, 95% CI 1.73-4.44, increased physical activity (OR 1.89, 95% CI 1.06-3.39, and improved diet (OR 2.89, 95% CI 1.61-5.17. Conclusions More than half of the employees who voluntarily participated in a web-based HRA with tailored feedback, reported to have initiated health-behaviour change. Self-reported initiation of health-behaviour change was more frequent among those at high CVD risk and BMI levels. In

  8. Health Risk Assessments of Waste Combustion Emissions Using Surrogate Analyte Models

    Science.gov (United States)

    2013-03-01

    exhaustive study between burn pit exposures and long -term health effects was unable to conclude burn pit exposures as etiological factors (IOM, 2011...periodic occupational and environmental monitoring summary ( POEMS ), summarizing the measured risk assessments for an installation, as outlined by DoD...instructions (DoD, 2008; DoD, 2011). The LER differs from the POEMS in that the LER is an established record for an individual, based upon his or her

  9. Assessing risk: professional perspectives on work involving mental health and child care services.

    Science.gov (United States)

    Barbour, Rosaline S; Stanley, Nicky; Penhale, Bridget; Holden, Sue

    2002-11-01

    The assessment of risk is central to work with families where parental mental health needs and child care concerns coexist. This article reports on the findings of three interprofessional focus groups which examined professionals' experiences of working with such families. Specialisation and differing thresholds and codes were identified as factors which contributed to difficulties for practitioners and families and scepticism was expressed concerning the feasibility of a key worker system for this group. The issue of psychiatric diagnosis evoked ambivalent responses and was both valued as offering direction for planning interventions and seen as a means of labelling and excluding individuals from services. The focus group participants were aware that assessing risk placed families under considerable pressure, but practitioners themselves also appeared to experience an emphasis on risk as restrictive.

  10. Health Risk Assessment of Dietary Cadmium Intake: Do Current Guidelines Indicate How Much is Safe?

    Science.gov (United States)

    Satarug, Soisungwan; Vesey, David A.; Gobe, Glenda C.

    2017-01-01

    Background: Cadmium (Cd), a food-chain contaminant, is a significant health hazard. The kidney is one of the primary sites of injury after chronic Cd exposure. Kidney-based risk assessment establishes the urinary Cd threshold at 5.24 μg/g creatinine, and tolerable dietary intake of Cd at 62 μg/day per 70-kg person. However, cohort studies show that dietary Cd intake below a threshold limit and that tolerable levels may increase the risk of death from cancer, cardiovascular disease, and Alzheimer’s disease. Objective: We evaluated if the current tolerable dietary Cd intake guideline and urinary Cd threshold limit provide sufficient health protection. Discussion: Staple foods constitute 40–60% of total dietary Cd intake by average consumers. Diets high in shellfish, crustaceans, mollusks, spinach, and offal add to dietary Cd sources. Modeling studies predict the current tolerable dietary intake corresponding to urinary Cd of 0.70–1.85 μg/g creatinine in men and 0.95–3.07 μg/g creatinine in women. Urinary Cd levels of protection from this pervasive toxic metal. Citation: Satarug S, Vesey DA, Gobe GC. 2017. Health risk assessment of dietary cadmium intake: do current guidelines indicate how much is safe? Environ Health Perspect 125:284–288; http://dx.doi.org/10.1289/EHP108 PMID:28248635

  11. Application of data fusion in human health risk assessment for hydrocarbon mixtures on contaminated sites.

    Science.gov (United States)

    Dyck, Roberta; Islam, M Shafiqul; Zargar, Amin; Mohapatra, Asish; Sadiq, Rehan

    2013-11-16

    The exposure and toxicological data used in human health risk assessment are obtained from diverse and heterogeneous sources. Complex mixtures found on contaminated sites can pose a significant challenge to effectively assess the toxicity potential of the combined chemical exposure and to manage the associated risks. A data fusion framework has been proposed to integrate data from disparate sources to estimate potential risk for various public health issues. To demonstrate the effectiveness of the proposed data fusion framework, an illustrative example for a hydrocarbon mixture is presented. The Joint Directors of Laboratories Data Fusion architecture was selected as the data fusion architecture and Dempster-Shafer Theory (DST) was chosen as the technique for data fusion. For neurotoxicity response analysis, neurotoxic metabolites toxicological data were fused with predictive toxicological data and then probability-boxes (p-boxes) were developed to represent the toxicity of each compound. The neurotoxic response was given a rating of "low", "medium" or "high". These responses were then weighted by the percent composition in the illustrative F1 hydrocarbon mixture. The resulting p-boxes were fused according to DST's mixture rule of combination. The fused p-boxes were fused again with toxicity data for n-hexane. The case study for F1 hydrocarbons illustrates how data fusion can help in the assessment of the health effects for complex mixtures with limited available data.

  12. Human health risk assessment (HHRA) for environmental development and transfer of antibiotic resistance

    DEFF Research Database (Denmark)

    Ashbolt, Nicholas J.; Amézquita, Alejandro; Backhaus, Thomas

    2013-01-01

    ) identifying and describing rates of horizontal gene transfer (HGT) in the relevant environmental "hot spot" compartments; and c) modifying traditional dose-response approaches to address doses of ARB for various health outcomes and pathways. Conclusions: We propose that environmental aspects of antibiotic......Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks. Objective: We examined possible approaches and sought to identify research needs...

  13. Aggregate human health risk assessment from dust of daily life in the urban environment of Beijing.

    Science.gov (United States)

    Xu, L Y; Shu, X

    2014-04-01

    Because of the high emissions of polycyclic aromatic hydrocarbons (PAHs) into the environment by the increasing number of vehicles in Beijing and the absorption of these PAHs onto particulates, the performance of a preliminary health risk assessment of the aggregate exposure to PAHs of urban citizens in daily life is very important. Urban dust can be used to examine the aggregation of atmospheric particulates from local pollution sources over a long time period and the direct exposure of the urban human population. The environment's correlative with clothing, dining, residing, and traveling in urban daily life was assessed using exposure-receptor-oriented analysis. The multipathway exposure model was used to simulate the lifetime exposure of a female citizen to PAHs in dust. All of the PAH concentrations in dust for each behavior and its correlative environment in Beijing were acceptable because all of the carcinogenic risks of PAHs in the dust were approximately 1.0 × 10(-6). The dominant induced carcinogenic risks in the dust were Benzo(a)pyrene and Dibenzo(a,h)anthracene. The main carcinogenic risk routes for humans were dermal contact and oral intake, which contributed on average 99.78% of the risk. Indoor risk is especially important, as the decoration and height within the building were important impact factors for carcinogenic risk induced by indoor PAHs. For people living in an urban area, a healthy lifestyle includes less decoration per room, living on a low floor, wearing a respirator, and reducing exposed skin area when traveling.

  14. Access and use of information resources in assessing health risks from chemical exposure: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1990-12-31

    Health risk assessment is based on access to comprehensive information about potentially hazardous agents in question. Relevant information is scattered throughout the literature, and often is not readily accessible. To be useful in assessment efforts, emerging scientific findings, risk assess parameters, and associated data must be compiled and evaluated systemically. The US Environmental Protection Agency (EPA) and Oak Ridge National Laboratory (ORNL) are among the federal agencies heavily involved in this effort. This symposium was a direct response by EPA and ORNL to the expressed needs of individuals involved in assessing risks from chemical exposure. In an effort to examine the state of the risk assessment process, the availability of toxicological information, and the future development and transfer of this information, the symposium provided an excellent cadre of speakers and participants from state and federal agencies, academia and research laboratories to address these topics. This stimulating and productive gathering discussed concerns associated with (1) environmental contamination by chemicals; (2) laws regulating chemicals; (3) information needs and resources; (4) applications; (5) challenges and priorities; and (6)future issues. Individual reports are processed separately for the data bases.

  15. Assessment of health risks due to arsenic from iron ore lumps in a beach setting.

    Science.gov (United States)

    Swartjes, Frank A; Janssen, Paul J C M

    2016-09-01

    In 2011, an artificial hook-shaped peninsula of 128ha beach area was created along the Dutch coast, containing thousands of iron ore lumps, which include arsenic from natural origin. Elemental arsenic and inorganic arsenic induce a range of toxicological effects and has been classified as proven human carcinogens. The combination of easy access to the beach and the presence of arsenic raised concern about possible human health effects by the local authorities. The objective of this study is therefore to investigate human health risks from the presence of arsenic-containing iron ore lumps in a beach setting. The exposure scenarios underlying the human health-based risk limits for contaminated land in The Netherlands, based on soil material ingestion and a residential setting, are not appropriate. Two specific exposure scenarios related to the playing with iron ore lumps on the beach ('sandcastle building') are developed on the basis of expert judgement, relating to children in the age of 2 to 12years, i.e., a worst case exposure scenario and a precautionary scenario. Subsequently, exposure is calculated by the quantification of the following factors: hand loading, soil-mouth transfer effectivity, hand-mouth contact frequency, contact surface, body weight and the relative oral bioavailability factor. By lack of consensus on a universal reference dose for arsenic for use in the stage of risk characterization, three different types of assessments have been evaluated: on the basis of the current Provisional Tolerable Daily Intake (PTWI), on the basis of the Benchmark Dose Lower limit (BMDL), and by a comparison of exposure from the iron ore lumps with background exposure. It is concluded, certainly from the perspective of the conservative exposure assessment, that unacceptable human health risks due to exposure to arsenic from the iron ore lumps are unlikely and there is no need for risk management actions.

  16. Addressing Human Variability in Next-Generation Human Health Risk Assessments of Environmental Chemicals

    Science.gov (United States)

    Bois, Frederic Y.; Chiu, Weihsueh A.; Hattis, Dale; Rusyn, Ivan; Guyton, Kathryn Z.

    2012-01-01

    Background: Characterizing variability in the extent and nature of responses to environmental exposures is a critical aspect of human health risk assessment. Objective: Our goal was to explore how next-generation human health risk assessments may better characterize variability in the context of the conceptual framework for the source-to-outcome continuum. Methods: This review was informed by a National Research Council workshop titled “Biological Factors that Underlie Individual Susceptibility to Environmental Stressors and Their Implications for Decision-Making.” We considered current experimental and in silico approaches, and emerging data streams (such as genetically defined human cells lines, genetically diverse rodent models, human omic profiling, and genome-wide association studies) that are providing new types of information and models relevant for assessing interindividual variability for application to human health risk assessments of environmental chemicals. Discussion: One challenge for characterizing variability is the wide range of sources of inherent biological variability (e.g., genetic and epigenetic variants) among individuals. A second challenge is that each particular pair of health outcomes and chemical exposures involves combinations of these sources, which may be further compounded by extrinsic factors (e.g., diet, psychosocial stressors, other exogenous chemical exposures). A third challenge is that different decision contexts present distinct needs regarding the identification—and extent of characterization—of interindividual variability in the human population. Conclusions: Despite these inherent challenges, opportunities exist to incorporate evidence from emerging data streams for addressing interindividual variability in a range of decision-making contexts. PMID:23086705

  17. Human health risk assessment in restoring safe and productive use of abandoned contaminated sites.

    Science.gov (United States)

    Wcisło, Eleonora; Bronder, Joachim; Bubak, Anicenta; Rodríguez-Valdés, Eduardo; Gallego, José Luis R

    2016-09-01

    In Europe soil contamination has been recognized as a serious problem. The needs to remediate contaminated sites are not questionable, although the remediation actions are often hindered by their very high financial costs. On the other hand, the abandoned contaminated sites may have the potential for redevelopment and creating conditions appropriate for their productive reuse bringing social, economic and environmental benefits. The main concern associated with the contaminated sites is their potential adverse health impact. Therefore, in the process of contaminated site redevelopment the risk assessment and the subsequent risk management decisions will play a crucial role. The main objective of this study was to illustrate the role of the human health risk assessment (HRA) in supporting site remediation and reuse decisions. To exemplify the significance of the HRA process in this field the Nitrastur site, located in Asturias, Spain was used. Risks resulting from soil contamination with arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), nickel (Ni), mercury (Hg), zinc (Zn) and lead (Pb) were assessed under three potential future land use patterns: industrial, residential and recreational. The results of the study indicated that soil at the Nitrastur site might pose non-cancer and cancer risks to potential future receptors - industrial workers, residents and recreational users. Arsenic and lead are the main substances responsible for the health risk and the primary drivers of remedial decisions at the site. The highest total cancer risks were observed under the residential scenario, followed in descending order by the recreational and industrial ones. The remedial maps illustrate in which areas remediation activities are required, depending on a given land use pattern. The obtained results may be used to develop, analyse, compare and select the remedial options within the intended land use pattern. They may also be used to support the decisions concerning the

  18. Accumulation of Heavy Metals in Vegetable Species Planted in Contaminated Soils and the Health Risk Assessment.

    Science.gov (United States)

    Zhou, Hang; Yang, Wen-Tao; Zhou, Xin; Liu, Li; Gu, Jiao-Feng; Wang, Wen-Lei; Zou, Jia-Ling; Tian, Tao; Peng, Pei-Qin; Liao, Bo-Han

    2016-03-04

    The objectives of the present study were to investigate heavy metal accumulation in 22 vegetable species and to assess the human health risks of vegetable consumption. Six vegetable types were cultivated on farmland contaminated with heavy metals (Pb, Cd, Cu, Zn, and As). The target hazard quotient (THQ) method was used to assess the human health risks posed by heavy metals through vegetable consumption. Clear differences were found in the concentrations of heavy metals in edible parts of the different vegetables. The concentrations of heavy metals decreased in the sequence as leafy vegetables > stalk vegetables/root vegetables/solanaceous vegetables > legume vegetables/melon vegetables. The ability of leafy vegetables to uptake and accumulate heavy metals was the highest, and that of melon vegetables was the lowest. This indicated that the low accumulators (melon vegetables) were suitable for being planted on contaminated soil, while the high accumulators (leafy vegetables) were unsuitable. In Shizhuyuan area, China, the total THQ values of adults and children through consumption of vegetables were 4.12 and 5.41, respectively, suggesting that the residents may be facing health risks due to vegetable consumption, and that children were vulnerable to the adverse effects of heavy metal ingestion.

  19. An assessment of mercury emissions and health risks from a coal-fired power plant

    Energy Technology Data Exchange (ETDEWEB)

    Fthenakis, V.M.; Lipfert, F.W.; Moskowitz, P.D.; Saroff, L. [Brookhaven National Laboratory, Upton, NY (United States)

    1995-12-01

    Title III of the 1990 Clean Air Act Amendments (CAAA) directed the US Environmental Protection Agency (EPA) to evaluate the rate and effect of mercury emissions in the atmosphere and technologies to control the emissions. The US DOE sponsored a risk assessment project at Brookhaven (BNL) to evaluate health risks of mercury emissions from coal combustion. Methylmercury (MeHg) is the compound predominantly responsible for human exposure to atmospheric mercury in the United States, through fish ingestion. In the BNL study, health risks to adults resulting from Hg emissions from a hypothetical coal-fired power plant were estimated using probabilistic risk assessment techniques. This study showed that the effects of emissions of a single large power plant may double the background exposures to MeHg resulting from consuming fish obtained from a localized are near the power plant. Even at these more elevated exposure levels, the attributable incidence in mild neurological symptoms (paresthesia) was estimated to be quite small, especially when compared with the estimated background incidence in the population. 29 refs., 5 figs., 2 tabs.

  20. Bioavailability and health risk assessment of potentially toxic elements in Thriasio Plain, near Athens, Greece.

    Science.gov (United States)

    Antoniadis, Vasileios; Golia, Evangelia E; Shaheen, Sabry M; Rinklebe, Jörg

    2017-04-01

    Elevated concentrations of potentially toxic elements (PTEs) are usually found in areas of intense industrial activity. Thriasio Plain is a plain near Athens, Greece, where most of the heavy industry of the country has been situated for decades, but it also is a residential and horticultural area. We aimed at measuring the levels of PTEs in soils and indigenous plant species and assessing the health risk associated with direct soil ingestion. Samples of soils at roadsides and growing plants were collected from 31 sites of that area. Concentrations of Al, As, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, V and Zn were measured in both soils (as pseudo-total) and aerial plant tissues. We found that As, Cd, Cr, Cu, Ni, Pb and Zn were higher than maximum regulatory limits. Element concentrations in plants were rather lower than expected, probably because indigenous plants have developed excluder behaviour over time. Copper and Zn soil-to-plant coefficients were highest among the other elements; for Cu this was unexpected, and probably associated with recent Cu-releasing industrial activity. Risk assessment analysis indicated that As was the element contributing more than 50 % of the health risk related to direct soil ingestion, followed by Cr, Pb, and, surprisingly, Mn. We concluded that in a multi-element contamination situation, elevated risk of PTEs (such as As, Cr and Pb) may reduce the tolerance limits of exposure to less-toxic elements (here, Mn).

  1. PS2-6: Using Health Risk Assessments to Understand Older Adult Sedentary Time

    Science.gov (United States)

    Rosenberg, Dori; Grothaus, Louis; Gell, Nancy; Renz, Anne; Arterburn, David

    2014-01-01

    Background/Aims Sedentary time (ST) is independently associated with cardio-metabolic conditions and mortality. Older adults have the highest levels of ST of all age groups. Little is known about how ST relates to BMI, health conditions, and health costs in older adults. Our aim was to use electronic health records (EHR) to better explore these relationships. Methods We extracted health risk assessment data (HRA), outpatient visit diagnosis codes, and total healthcare costs from the EHR of a large health plan in WA State (Group Health). All members aged 65–99 who completed an HRA in 2011 and were continuously enrolled for 2 years, did not reside in long-term care, or have a terminal health condition were included (N = 3967; ~10% of all eligible members). ST was assessed by the International Physical Activity (PA) Questionnaire sitting item. BMI was calculated using most recent weight and height from the EHR. Cardiovascular disease and diabetes were identified using ICD-9 codes. We used regression analysis to determine how mean ST varied with factors such as diabetes, while controlling for age, gender, race, ethnicity, BMI, diet, and hours of PA per week. Results Age and PA were strongly related to ST. Obese participants (BMI >30 (24% of the sample) had significantly higher mean ST (6.75 hours/day, P <.001) compared to overweight (6.06) and normal weight (5.67) older adults. Those with diabetes (14% of the sample), had significantly higher ST (6.42 hours/day) than those without (6 hours/day; P = .01). Total healthcare costs increase on average $139 for each additional hour of sitting (P = .03). Conclusions After adjusting for demographic, health behaviors, and health conditions, older adults with a higher BMI, diabetes, and higher total healthcare costs had greater self-reported ST. These patterns indicate that ST may be an important health behavior to target for intervention as people age.

  2. Assessment of public health risk associated with viral contamination in harvested urban stormwater for domestic applications

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Keah-Ying [Department of Civil and Environmental Engineering, University of California, Irvine, CA 92617-2175 (United States); Hamilton, Andrew J. [Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Dookie Campus, Currawa, VIC 3647 (Australia); Federation University Australia, Mt Helen Campus, VIC 3353 (Australia); Jiang, Sunny C., E-mail: sjiang@uci.edu [Department of Civil and Environmental Engineering, University of California, Irvine, CA 92617-2175 (United States)

    2015-08-01

    Capturing stormwater is becoming a new standard for sustainable urban stormwater management, which can be used to supplement water supply portfolios in water-stressed cities. The key advantage of harvesting stormwater is to use low impact development (LID) systems for treatment to meet water quality requirement for non-potable uses. However, the lack of scientific studies to validate the safety of such practice has limited its adoption. Microbial hazards in stormwater, especially human viruses, represent the primary public health threat. Using adenovirus and norovirus as target pathogens, we investigated the viral health risk associated with a generic scenario of urban stormwater harvesting practice and its application for three non-potable uses: 1) toilet flushing, 2) showering, and 3) food-crop irrigation. The Quantitative Microbial Risk Assessment (QMRA) results showed that food-crop irrigation has the highest annual viral infection risk (median range: 6.8 × 10{sup −4}–9.7 × 10{sup −1} per-person-per-year or pppy), followed by showering (3.6 × 10{sup −7}–4.3 × 10{sup −2} pppy), and toilet flushing (1.1 × 10{sup −7}–1.3 × 10{sup −4} pppy). Disease burden of each stormwater use was ranked in the same order as its viral infection risk: food-crop irrigation > showering > toilet flushing. The median and 95th percentile risk values of toilet-flushing using treated stormwater are below U.S. EPA annual risk benchmark of ≤ 10{sup −4} pppy, whereas the disease burdens of both toilet-flushing and showering are within the WHO recommended disease burdens of ≤ 10{sup −6} DALYs pppy. However, the acceptability of showering risk interpreted based on the U.S. EPA and WHO benchmarks is in disagreement. These results confirm the safety of stormwater application in toilet flushing, but call for further research to fill the data gaps in risk modeling as well as risk benchmarks. - Highlights: • Human health risks for three non-potable uses of treated

  3. Occurrence of pharmaceuticals in a water supply system and related human health risk assessment.

    Science.gov (United States)

    de Jesus Gaffney, Vanessa; Almeida, Cristina M M; Rodrigues, Alexandre; Ferreira, Elisabete; Benoliel, Maria João; Cardoso, Vitor Vale

    2015-04-01

    A monitoring study of 31 pharmaceuticals along Lisbon's drinking water supply system was implemented, which comprised the analysis of 250 samples including raw water (surface water and groundwater), and drinking water. Of the 31 pharmaceutical compounds, only sixteen were quantified in the analyzed samples, with levels ranging from 0.005 to 46 ng/L in raw water samples and 0.09-46 ng/L in drinking water samples. The human health risk assessment performed showed that appreciable risks to the consumer's health arising from exposure to trace levels of pharmaceuticals in drinking water are extremely unlikely, as RQs values were all below 0.001. Also, pharmaceuticals were selected as indicators to be used as a tool to control the quality of raw water and the treatment efficiency in the drinking water treatment plants.

  4. Health Risk Assessment using in vitro digestion model in assessing bioavailability of heavy metal in rice: A preliminary study.

    Science.gov (United States)

    Omar, N A; Praveena, S M; Aris, A Z; Hashim, Z

    2015-12-01

    Little is known about the bioavailability of heavy metal contamination and its health risks after rice ingestion. This study aimed to determine bioavailability of heavy metal (As, Cd, Cu, Cr, Co, Al, Fe, Zn and Pb) concentrations in cooked rice and human Health Risk Assessment (HRA). The results found Zn was the highest (4.3±0.1 mg/kg), whereas As showed the lowest (0.015±0.001 mg/kg) bioavailability of heavy metal concentration in 22 varieties of cooked rice. For single heavy metal exposure, no potential of non carcinogenic health risks was found, while carcinogenic health risks were found only for As. Combined heavy metal exposures found that total Hazard Quotient (HQtotal) values for adult were higher than the acceptable range (HQTotal1×10(-4)) for both adult and children. This study is done to understand that the inclusion of bioavailability heavy metal into HRA produces a more realistic estimation of human heavy metal exposure.

  5. Spatial Analysis Based Health and Safety Risk Assessment for Linear Construction Projects

    Science.gov (United States)

    Atay, H.; Toz, G.

    2012-07-01

    This paper describes an on-going study that aims to develop a web-based spatial decision support system model for proactive health and safety management in linear construction projects. Currently, health and safety management is usually performed reactively instead of proactive management since hazard identification and risk assessment is mostly performed on paper based documents that are not effectively used at site. This leads to accidents and fatalities at construction sites. The proposed system automatically identifies the spatial risks according to the topographic and layout map of the site, project specification and health and safety regulations by means of spatial analysis. It enables the workers and management personnel to access the possible hazards and thematic risk map of any portion of the construction site for linear projects. Finally, the described approach provides the proposed mitigation measures for the identified hazards. The developed system is expected to raise awareness in H&S among workers and engineers, and increase participation of workers to health and safety management.

  6. SPATIAL ANALYSIS BASED HEALTH AND SAFETY RISK ASSESSMENT FOR LINEAR CONSTRUCTION PROJECTS

    Directory of Open Access Journals (Sweden)

    H. Atay

    2012-07-01

    Full Text Available This paper describes an on-going study that aims to develop a web-based spatial decision support system model for proactive health and safety management in linear construction projects. Currently, health and safety management is usually performed reactively instead of proactive management since hazard identification and risk assessment is mostly performed on paper based documents that are not effectively used at site. This leads to accidents and fatalities at construction sites. The proposed system automatically identifies the spatial risks according to the topographic and layout map of the site, project specification and health and safety regulations by means of spatial analysis. It enables the workers and management personnel to access the possible hazards and thematic risk map of any portion of the construction site for linear projects. Finally, the described approach provides the proposed mitigation measures for the identified hazards. The developed system is expected to raise awareness in H&S among workers and engineers, and increase participation of workers to health and safety management.

  7. Nitrate and nitrite in the diet: how to assess their benefit and risk for human health.

    Science.gov (United States)

    Habermeyer, Michael; Roth, Angelika; Guth, Sabine; Diel, Patrick; Engel, Karl-Heinz; Epe, Bernd; Fürst, Peter; Heinz, Volker; Humpf, Hans-Ulrich; Joost, Hans-Georg; Knorr, Dietrich; de Kok, Theo; Kulling, Sabine; Lampen, Alfonso; Marko, Doris; Rechkemmer, Gerhard; Rietjens, Ivonne; Stadler, Richard H; Vieths, Stefan; Vogel, Rudi; Steinberg, Pablo; Eisenbrand, Gerhard

    2015-01-01

    Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However, their relevance for human health has not been adequately explored up to now. Nitrate and nitrite are per se not carcinogenic, but under conditions that result in endogenous nitrosation, it cannot be excluded that ingested nitrate and nitrite may lead to an increased cancer risk and may probably be carcinogenic to humans. In this review, the known beneficial and detrimental health effects related to dietary nitrate/nitrite intake are described and the identified gaps in knowledge as well as the research needs required to perform a reliable benefit/risk assessment in terms of long-term human health consequences due to dietary nitrate/nitrite intake are presented.

  8. A review of soil cadmium contamination in China including a health risk assessment.

    Science.gov (United States)

    Wang, Lin; Cui, Xiangfen; Cheng, Hongguang; Chen, Fei; Wang, Jiantong; Zhao, Xinyi; Lin, Chunye; Pu, Xiao

    2015-11-01

    Cadmium (Cd) is one of the most serious soil contaminants in China, and it poses an increasing risk to human health as large amounts of Cd are emitted into the environment. However, knowledge about soil Cd concentrations and the human health risks of these concentrations at a national scale is limited. In this study, we conducted a review of 190 articles about soil Cd concentrations during 2001 to 2010. The study involved 146 cities in China, and we quantified the risks to human health according to different regions. The results showed that elevated Cd levels were present compared to the background value of soil in 1990, and the soil Cd concentrations in the Guangxi province exceeded even the class III Soil Environmental Quality standard, which is the limit for the normal growth of plants. The Chinese soil Cd concentrations ranged from 0.003 mg kg(-1) to 9.57 mg kg(-1). The soil Cd concentrations had the following trend: northwest > southwest > south central > east > northeast > north. The sources of soil Cd are mainly from smelting, mining, waste disposal, fertilizer and pesticide application, and vehicle exhaust, etc. but differentiated in various regions. The soil Cd contamination in urban areas was more serious than contamination in the agricultural areas. Currently, there is no significant non-carcinogenic risk in any of the provinces. Regarding the different exposure pathways, the dermal pathway is the primary source of soil Cd exposure, and the risk associated with this pathway is generally hundreds of times higher than the risk for an ingestion pathway. For most of the provinces, the health risk to the urban population was higher than the risk to the rural population. For each population, the carcinogenic risk was less than 10(-6) in most of the provinces, except for the urban population in the Hunan province. If the other exposure pathways are fully considered, then the people in these areas may have a higher carcinogenic risk. This

  9. [Pollution evaluation and health risk assessment of heavy metals from atmospheric deposition in Lanzhou].

    Science.gov (United States)

    Li, Ping; Xue, Su-Yin; Wang, Sheng-Li; Nan, Zhong-Ren

    2014-03-01

    In order to evaluate the contamination and health risk of heavy metals from atmospheric deposition in Lanzhou, samples of atmospheric deposition were collected from 11 sampling sites respectively and their concentrations of heavy metals were determined. The results showed that the average contents of Cu, Pb, Cd, Cr, Ni, Zn and Mn were 82.22, 130.31, 4.34, 88.73, 40.64, 369.23 and 501.49 mg x kg(-1), respectively. There was great difference among different functional areas for all elements except Mn. According to the results, the enrichment factor score of Mn was close to 1, while the enrichment of Zn, Ni, Cu and Cr was more serious, and Pb and Cd were extremely enriched. The assessment results of geoaccumulation index of potential ecological risk indicated that the pollution of Cd in the atmospheric deposition of Lanzhou should be classified as extreme degree, and that of Cu, Ni, Zn, Pb as between slight and extreme degrees, and Cr as practically uncontaminated. Contaminations of atmospheric dust by heavy metals in October to the next March were more serious than those from April to August. Health risk assessment indicated that the heavy metals in atmospheric deposition were mainly ingested by human bodies through hand-mouth ingestion. The non-cancer risk was higher for children than for adults. The order of non-cancer hazard indexes of heavy metals was Pb > Cr > Cd > Cu > Ni > Zn. The non-cancer hazard indexes and carcinogen risks of heavy metals were both lower than their threshold values, suggesting that they will not harm the health.

  10. Occupational health risk assessment and exposure to floor dust PAHs inside an educational building.

    Science.gov (United States)

    Maragkidou, Androniki; Arar, Sharif; Al-Hunaiti, Afnan; Ma, Yuning; Harrad, Stuart; Jaghbeir, Omar; Faouri, Dina; Hämeri, Kaarle; Hussein, Tareq

    2017-02-01

    Polycyclic aromatic hydrocarbons (PAHs) settled in floor dust play an important role in human health. Although many studies investigated occupational exposure to PAHs, no attempts have been made to report PAHs concentrations as well as their health risk assessment inside an educational building in Jordan. Therefore, the main objective of this study is to report the PAHs concentrations in floor dust and evaluate their exposure and health risk inside the Department of Physics of the University of Jordan. The total PAHs concentrations ranged from 714 to 5246ng/g. The high concentrations were observed inside some offices, where tobacco smoking took place. One of those offices was previously renovated and some petrochemical liquids were used to remove the remaining glue from a previous carpet. Interestingly, the PAHs inside these offices were higher than those reported inside lecture rooms and the workshop area, where extensive activates of heavy machinery and use of petroleum products (such as lubricating oils). This implies that the health effects of exposure to tobacco smoking inside small micro-environmental places that are poorly ventilated can be very harmful. We also made a simple exposure and health risk assessment for the ingested dust (hand-to-mouth) by calculating the Estimated Daily Intake (EDI) and benzo(a)pyrene equivalent carcinogenic power (BaPE). The total EDI was less than 3.75ng/kg-bw/day whereas the BaPE was less than 385ng/g. These values are lower than what was reported in some previous studies in Europe and Asia.

  11. The relevance of the early history of probability theory to current risk assessment practices in mental health care.

    Science.gov (United States)

    Large, Matthew

    2013-12-01

    Probability theory is at the base of modern concepts of risk assessment in mental health. The aim of the current paper is to review the key developments in the early history of probability theory in order to enrich our understanding of current risk assessment practices.

  12. Health risk assessments of heavy metal exposure via consumption of marine mussels collected from anthropogenic sites

    Energy Technology Data Exchange (ETDEWEB)

    Yap, Chee Kong, E-mail: yapckong@hotmail.com [Department of Biology, Faculty of Science, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor (Malaysia); Cheng, Wan Hee [Inti International University, Persiaran Perdana BBN, 71800 Nilai, Negeri Sembilan (Malaysia); Karami, Ali [Laboratory of Aquatic Toxicology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor (Malaysia); Ismail, Ahmad [Department of Biology, Faculty of Science, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor (Malaysia)

    2016-05-15

    A total of 40 marine mussel Perna viridis populations collected (2002–2009) from 20 geographical sites located in two busy shipping lanes namely the Straits of Malacca (10 sites; 16 populations) and the Straits of Johore (8 sites; 21 populations) and three populations (2 sites) on the east coast of Peninsular Malaysia, was determined for Cd, Cu, Fe, Ni, Pb and Zn concentrations. In comparison with the maximum permissible limits (MPLs) set by existing food safety guidelines, all metal concentrations found in all the mussel populations were lower than the prescribed MPLs. In terms of the provisional tolerable weekly intake prescribed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) and oral reference doses (ORDs) by the USEPA, all the studied metals (except for Pb) were unlikely to become the limiting factors or unlikely to pose a risk for the consumption of the mussel populations. The estimated daily intake (EDI) for average level mussel (ALM) and high level mussel (HLM) consumers of mussels was found to be lower than the ORD guidelines for Cd, Cu, Fe, Ni and Zn. Furthermore, the target hazard quotient (THQ) was found to be less than 1 for ALM consumers but higher than 1 for HLM consumers in some sites. Therefore, there were no potential human health risks to the ALM consumers of the mussels. However, for Pb THQ values, the Pb levels in some mussel populations could create a health risk problem. Present results indicate that the consumption amounts of mussels should be limited for minimizing potential health risks of heavy metals to the HLM consumers. - Highlights: • Human health risk assessments of heavy metals in Perna viridis were investigated. • All metals in the mussels were below the established seafood safety guidelines. • Pb in mussels could easily reach the percentage of prescribed PTWI value of Pb. • Potential health risk with Pb exposure was found for the mussel consumers. • Consumption rate of mussels should be limited to

  13. Human Health and Ecological Risk Assessment Work Plan Mud Pit Release Sites, Amchitka Island, Alaska

    Energy Technology Data Exchange (ETDEWEB)

    DOE/NV

    2001-03-12

    This Work Plan describes the approach that will be used to conduct human health and ecological risk assessments for Amchitka Island, Alaska, which was utilized as an underground nuclear test site between 1965 and 1971. During this period, the U.S. Atomic Energy Commission (now the U.S. Department of Energy) conducted two nuclear tests (known as Long Shot and Milrow) and assisted the U.S. Department of Defense with a third test (known as Cannikin). Amchitka Island is approximately 42 miles long and located 1,340 miles west-southwest of Anchorage, Alaska, in the western end of the Aleutian Island archipelago in a group of islands known as the Rat Islands. Historically including deep drilling operations required large volumes of drilling mud, a considerable amount of which was left on the island in exposed mud pits after testing was completed. Therefore, there is a need for drilling mud pit remediation and risk assessment of historical mud pit releases. The scope of this work plan is to document the environmental objectives and the proposed technical site investigation strategies that will be utilized for the site characterization of the constituents in soil, surface water, and sediment at these former testing sites. Its goal is the collection of data in sufficient quantity and quality to determine current site conditions, support a risk assessment for the site surfaces, and evaluate what further remedial action is required to achieve permanent closure of these three sites that will protect both human health and the environment. Suspected compounds of potential ecological concern for investigative analysis at these sites include diesel-range organics, polyaromatic hydrocarbons, polychlorinated biphenyls, volatile organic compounds, and chromium. The results of these characterizations and risk assessments will be used to evaluate corrective action alternatives to include no further action, the implementation of institutional controls, capping on site, or off-sit e

  14. Health Risk Assessment of Cyanobacterial (Blue-green Algal Toxins in Drinking Water

    Directory of Open Access Journals (Sweden)

    Andrew R. Humpage

    2005-04-01

    Full Text Available Cyanobacterial toxins have caused human poisoning in the Americas, Europe and Australia. There is accumulating evidence that they are present in treated drinking water supplies when cyanobacterial blooms occur in source waters. With increased population pressure and depleted groundwater reserves, surface water is becoming more used as a raw water source, both from rivers and lakes/reservoirs. Additional nutrients in water which arise from sewage discharge, agricultural run-off or storm water result in overabundance of cyanobacteria, described as a ‘water bloom’. The majority of cyanobacterial water-blooms are of toxic species, producing a diversity of toxins. The most important toxins presenting a risk to the human population are the neurotoxic alkaloids (anatoxins and paralytic shellfish poisons, the cyclic peptide hepatotoxins (microcystins and the cytotoxic alkaloids (cylindrospermopsins. At the present time the only cyanobacteral toxin family that have been internationally assessed for health risk by the WHO are the microcystins, which cause acute liver injury and are active tumour promoters. Based on sub-chronic studies in rodents and pigs, a provisional Guideline Level for drinking water of 1μg/L of microcystin-LR has been determined. This has been adopted in legislation in countries in Europe, South America and Australasia. This may be revised in the light of future teratogenicity, reproductive toxicity and carcinogenicity studies. The other cyanobacterial toxin which has been proposed for detailed health risk assessment is cylindrospermopsin, a cytotoxic compound which has marked genotoxicity, probable mutagenicity, and is a potential carcinogen. This toxin has caused human poisoning from drinking water, and occurs in water supplies in the USA, Europe, Asia, Australia and South America. An initial health risk assessment is presented with a proposed drinking water Guideline Level of 1μg/L. There is a

  15. Application of GIS and modelling in health risk assessment for urban road mobility.

    Science.gov (United States)

    Vu, Van-Hieu; Le, Xuan-Quynh; Pham, Ngoc-Ho; Hens, Luc

    2013-08-01

    Transport is an essential sector in modern societies. It connects economic sectors and industries. Next to its contribution to economic development and social interconnection, it also causes adverse impacts on the environment and results in health hazards. Transport is a major source of ground air pollution, especially in urban areas, and therefore contributes to the health problems, such as cardiovascular and respiratory diseases, cancer and physical injuries. This paper presents the results of a health risk assessment that quantifies the mortality and the diseases associated with particulate matter pollution resulting from urban road transport in Haiphong City, Vietnam. The focus is on the integration of modelling and geographic information system approaches in the exposure analysis to increase the accuracy of the assessment and to produce timely and consistent assessment results. The modelling was done to estimate traffic conditions and concentrations of particulate matters based on geo-referenced data. The study shows that health burdens due to particulate matter in Haiphong include 1,200 extra deaths for the situation in 2007. This figure can double by 2020 as the result of the fast economic development the city pursues. In addition, 51,000 extra hospital admissions and more than 850,000 restricted activity days are expected by 2020.

  16. A Bayesian Approach to Integrated Ecological and Human Health Risk Assessment for the South River, Virginia Mercury-Contaminated Site.

    Science.gov (United States)

    Harris, Meagan J; Stinson, Jonah; Landis, Wayne G

    2017-01-25

    We conducted a regional-scale integrated ecological and human health risk assessment by applying the relative risk model with Bayesian networks (BN-RRM) to a case study of the South River, Virginia mercury-contaminated site. Risk to four ecological services of the South River (human health, water quality, recreation, and the recreational fishery) was evaluated using a multiple stressor-multiple endpoint approach. These four ecological services were selected as endpoints based on stakeholder feedback and prioritized management goals for the river. The BN-RRM approach allowed for the calculation of relative risk to 14 biotic, human health, recreation, and water quality endpoints from chemical and ecological stressors in five risk regions of the South River. Results indicated that water quality and the recreational fishery were the ecological services at highest risk in the South River. Human health risk for users of the South River was low relative to the risk to other endpoints. Risk to recreation in the South River was moderate with little spatial variability among the five risk regions. Sensitivity and uncertainty analysis identified stressors and other parameters that influence risk for each endpoint in each risk region. This research demonstrates a probabilistic approach to integrated ecological and human health risk assessment that considers the effects of chemical and ecological stressors across the landscape.

  17. Syndromes associated with children exposure to mycotoxins and health risk assessment to multiple mycotoxins in infant foods

    OpenAIRE

    Alvito, Paula; Martins, Carla; Assunção, Ricardo; Pires, M.J.; Calhau, Maria Antónia

    2015-01-01

    1. Children health and mycotoxins; 2. Routes of exposure; 3. Syndromes Syndromes associated associated with children children exposure exposure to mycotoxins: to mycotoxins: ingestion and inhalation; 4. Health risk assessment to multiple mycotoxins in infant foods -MYCOMIX project (PTDC/DTP-FTO/0417/2012); 5. Critical role of health professionals

  18. Health risk assessment for exposure to nitrate in drinking water from village wells in Semarang, Indonesia.

    Science.gov (United States)

    Sadler, Ross; Maetam, Brooke; Edokpolo, Benjamin; Connell, Des; Yu, Jimmy; Stewart, Donald; Park, M-J; Gray, Darren; Laksono, Budi

    2016-09-01

    The levels of nitrate in 52 drinking water wells in rural Central Java, Indonesia were evaluated in April 2014, and the results were used for a health risk assessment for the local populations by using probabilistic techniques. The concentrations of nitrate in drinking water had a range of 0.01-84 mg/L, a mean of 20 mg/L and a medium of 14 mg/L. Only two of the 52 samples exceeded the WHO guideline values of 50 mg/L for infant methaemoglobinaemia. The hazard quotient values as evaluated against the WHO guideline value at the 50 and 95 percentile points were HQ50 at 0.42 and HQ95 at 1.2, respectively. These indicated a low risk of infant methaemoglobinaemia for the whole population, but some risk for the sensitive portion of the population. The HQ50 and HQ95 values based on WHO acceptable daily intake dose for adult male and female were 0.35 and 1.0, respectively, indicating a generally a low level of risk. A risk characterisation linking birth defects to nitrate levels in water consumed during the first three months of pregnancy resulted in a HQ50/50 values of 1.5 and a HQ95/5 value of 65. These HQ values indicated an elevated risk for birth defects, in particular for the more sensitive population. A sanitation improvement program in the study area had a positive effect in reducing nitrate levels in wells and the corresponding risk for public health. For example, the birth defect HQ50/50 values for a subset of wells surveyed in both 2014 and 2015 was reduced from 1.1 to 0.71.

  19. Risk assessment in travel medicine.

    Science.gov (United States)

    Leggat, Peter A

    2006-01-01

    Risk assessment is an integral part of pre-travel and post- assessment. Risk assessment largely determines what health and safety advice and interventions are given within the relevant prevailing travel health guidelines. Risk assessment needs time and depends on information, including that given by the traveller. Risk assessment also needs to be documented. Risk assessment of the traveller preferably starts before they enter the consulting room, where travellers may complete a pre-travel health questionnaire. Armed with this information, risk assessment may be assisted by access to computerised travel health databases and the published literature. Experience of travel to the destination may also assist in risk assessment and the tour operator, overseas employer or agency, the traveller or even the travel health advisers themselves may provide this information.

  20. Distribution, sources and health risk assessment of mercury in kindergarten dust

    Science.gov (United States)

    Sun, Guangyi; Li, Zhonggen; Bi, Xiangyang; Chen, Yupeng; Lu, Shuangfang; Yuan, Xin

    2013-07-01

    Mercury (Hg) contamination in urban area is a hot issue in environmental research. In this study, the distribution, sources and health risk of Hg in dust from 69 kindergartens in Wuhan, China, were investigated. In comparison with most other cities, the concentrations of total mercury (THg) and methylmercury (MeHg) were significantly elevated, ranging from 0.15 to 10.59 mg kg-1 and from 0.64 to 3.88 μg kg-1, respectively. Among the five different urban areas, the educational area had the highest concentrations of THg and MeHg. The GIS mapping was used to identify the hot-spot areas and assess the potential pollution sources of Hg. The emissions of coal-power plants and coking plants were the main sources of THg in the dust, whereas the contributions of municipal solid waste (MSW) landfills and iron and steel smelting related industries were not significant. However, the emission of MSW landfills was considered to be an important source of MeHg in the studied area. The result of health risk assessment indicated that there was a high adverse health effect of the kindergarten dust in terms of Hg contamination on the children living in the educational area (Hazard index (HI) = 6.89).

  1. Health risk assessment for arsenic in water sources of cankiri province of Turkey

    Energy Technology Data Exchange (ETDEWEB)

    Caylak, Emrah [Department of Biochemistry, School of Health, Karatekin University, Cankiri (Turkey)

    2012-07-15

    To investigate the levels of arsenic (As) in the water sources of Cankiri Province, the samples were collected from the stations of central Cankiri (n = 27) and Kursunlu town (n = 12) during 2009 and 2010. The concentrations of As were analyzed with an atomic absorption spectrophotometer, and then compared with permissible limit, 10 {mu}g/L in drinking water, by Turkish legislation and World Health Organization (WHO). The As levels were higher than this limit (mean value 10-30 {mu}g/L in 26 stations), whereas, they were found to be >30 {mu}g/L in 12 sampling points. The water sources were categorized for health risk assessment such as reservoir, tap, well, and spring, and then chronic daily intake for oral and dermal exposure to As via drinking water, hazard quotient (HQ), and hazard index were calculated by using indices. The HQ values were found to be >1 in all samples of Cankiri Province. The effects of As on human health were then evaluated using carcinogenic risk (CR). CR values for As were also estimated to be >10{sup -5} in drinking water samples of Cankiri Province and might exert potential CR for people. These assessments would point out required drinking water treatment strategy to ensure safety of consumers. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  2. Environmental Health Risk Assessment of Dioxin Exposure through Foods in a Dioxin Hot Spot—Bien Hoa City, Vietnam

    OpenAIRE

    Tran Thi Tuyet-Hanh; Le Vu-Anh; Nguyen Ngoc-Bich; Thomas Tenkate

    2010-01-01

    This study used the Australian Environmental Health Risk Assessment Framework to assess the human health risk of dioxin exposure through foods for local residents in two wards of Bien Hoa City, Vietnam. These wards are known hot-spots for dioxin and a range of stakeholders from central government to local levels were involved in this process. Publications on dioxin characteristics and toxicity were reviewed and dioxin concentrations in local soil, mud, foods, milk and blood samples were used ...

  3. Assessment of arsenic (As) occurrence in arable soil and its related health risk in China.

    Science.gov (United States)

    Zhang, Xiuying; Zhong, Taiyang; Chen, Dongmei; Cheng, Min; Liu, Lei; Zhang, Xiaomin; Li, Xinhui

    2016-06-01

    Arsenic (As) is a major global environmental pollutant due to its high toxicity on human and animal health. This study collected 427 relevant papers to study As concentrations in Chinese arable soil and evaluate the health risk of exposure to As for humans. Results showed that the average of As concentration was 9.46 mg/kg in Chinese arable soil. Soil As concentrations in Hunan Province and Guangxi Zhuang Autonomous Region posed high carcinogenic and non-cancer risks on human health through diet, Yunnan, Guizhou, Guangdong, and Xinjiang provinces had relative high health risks, while As concentrations in the other provinces posed low health risks on humans. The physical factors controlled the spatial pattern of health risk on a provincial scale, but the As-related human activities introduced high health risk on people, particularly the agricultural activities such as sewage irrigation and fertilizer application should be given more attention due to its large area.

  4. Rapid health-risk assessment of effluent irrigation on an Australian university campus.

    Science.gov (United States)

    Derry, Chris; Attwater, Roger; Booth, Sandy

    2006-03-01

    Rapid health-risk assessment of chlorinated sewage-effluent irrigation of lawns, fields and crops adjacent to populated areas at the University of Western Sydney was carried out in response to warnings from the supplying authority of deteriorating bacteriological quality of the water. Irrigation with low-quality effluent offered potential for the contamination of a range of foodstuffs and the exposure of staff, students and visitors. The need for early investigation was emphasised by eutrophication presenting as sudden algal bloom in one of the campus dams and an odour suggestive of anaerobic proteolysis on irrigation. No baseline data existed regarding improvement or deterioration in water quality with passage through the dams, or relating to potential for direct or indirect exposure. The assessment design incorporated three methodologies to generate biophysical, environmental and social data. Environmental and social data were used to augment short-term data for biophysical indicators in the estimation of risk. Where required qualitative information was converted to quantitative data using categorical ranking tables, and risk evaluation was carried out using ranked risk and uncertainty values. Results for biophysical indicators showed a steady improvement in water quality with passage through campus dams, emphasising a need to regard the impoundments as part of a treatment chain, rather than as passive storage units. Effluent quality at most irrigation sites marginally exceeded regional action thresholds for relevant crop types, suggesting a need for risk management through revised irrigation practice, system design, distribution management and risk communication. Problems requiring urgent intervention included the concentration of contaminants of bovine faecal origin in one dam as the result of a closed loop within the reticulation. Also of concern was the exposure of certain most susceptible individuals including crèche children who visited pasture land and

  5. Integrated Environmental Health Impact Assessment for Risk Governance Purposes; Across What Do We Integrate?

    Science.gov (United States)

    Lebret, Erik

    2015-12-23

    Integrated Environmental Health Impact Assessment (IEHIA) can be considered as an element in the third phase of environmental risk management. Its focus is on providing inclusive descriptions of multiple impacts from multiple stressors in such a way that they can be evaluated against the potential societal benefits of the causes of the stressors. This paper emphasises some differences and difficulties in the integration across professional paradigms and scientific fields, across stakeholder perspectives and differences in impact indicators that emanate from these different fields and paradigms.

  6. An assessment of mercury emissions and health risks from a coal-fired power plant

    Energy Technology Data Exchange (ETDEWEB)

    Fthenakis, V.M.; Lipfert, F.; Moskowitz, P. [Brookhaven National Lab., Upton, NY (United States). Analytical Sciences Div.

    1994-12-01

    Title 3 of the 1990 Clean Air Act Amendments (CAAA) mandated that the US Environmental Protection Agency (EPA) evaluate the need to regulate mercury emissions from electric utilities. In support of this forthcoming regulatory analysis the U.S. DOE, sponsored a risk assessment project at Brookhaven (BNL) to evaluate methylmercury (MeHg) hazards independently. In the US MeHg is the predominant way of exposure to mercury originated in the atmosphere. In the BNL study, health risks to adults resulting from Hg emissions from a hypothetical 1,000 MW coal-fired power plant were estimated using probabilistic risk assessment techniques. This study showed that the effects of emissions of a single power plant may double the background exposures to MeHg resulting from consuming fish obtained from a localized area near the power plant. Even at these more elevated exposure levels, the attributable incidence in mild neurological symptoms was estimated to be quite small, especially when compared with the estimated background incidence in the population. The current paper summarizes the basic conclusions of this assessment and highlights issues dealing with emissions control and environmental transport.

  7. Heavy metal pollution and health risk assessment in the Wei River in China.

    Science.gov (United States)

    Yang, Xuefu; Duan, Jinming; Wang, Lei; Li, Wei; Guan, Jianling; Beecham, Simon; Mulcahy, Dennis

    2015-03-01

    From data collected monthly at 26 monitoring cross sections in the Wei River in the Shaanxi Region of China during the period 2008-2012, the temporal pollution characteristics of heavy metals (Hg, Cd, Cr(VI), Pb, and As) were analyzed based on a heavy metal pollution index (HPI). The monthly HPI values of the five heavy metals in the river fluctuated greatly in 2008 and then declined gradually with time. This general trend of reduction in HPI appears not to have a seasonal variation and most likely resulted from the continued improvement in heavy metal pollution control strategies implemented by local environmental agencies combined with a significant improvement in wastewater treatment capacities. Among the five heavy metals, Cd and Pb were below 0.1 and 3 μg L(-1), respectively, at all the sampling points in the studied areas in the year 2012. The detection rates of As, Hg, and Cr(VI) were in the order of Hg > Cr(VI) > As. Hg, Cr(VI), and As exceeded, in a month of the dry season in 2012, the standard limits for category III surface waters according to the China Environment Quality Standards for Surface Water (CEQSSW). Based on the assessment using the HPI method, the pollution status of these heavy metals in water of the Wei River in the Shaanxi Region was generally at an acceptable level, but exhibited distinctive characteristics between the main stream river and tributaries. Most of the tributaries were more seriously polluted than the main river. A health risk assessment was conducted based on the Human Health Risk Assessment (HHRA) method recommended by the United States Environmental Protection Agency (USEPA). Apart from As, the health risk for the five heavy metals in the region were at acceptable levels for drinking water sources (hazard quotient (HQ) pollutant of concern among the five heavy metals; both its values of the HQ and CR indicated potentially adverse health risks for the local population.

  8. Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins

    Science.gov (United States)

    Benner, W. Henry; Krauss, Ronald M.; Blanche, Patricia J.

    2010-12-14

    A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.

  9. Genetically modified lactic acid bacteria: applications to food or health and risk assessment.

    Science.gov (United States)

    Renault, Pierre

    2002-11-01

    Lactic acid bacteria have a long history of use in fermented food products. Progress in gene technology allows their modification by introducing new genes or by modifying their metabolic functions. These modifications may lead to improvements in food technology (bacteria better fitted to technological processes, leading to improved organoleptic properties em leader ), or to new applications including bacteria producing therapeutic molecules that could be delivered by mouth. Examples in these two fields will be discussed, at the same time evaluating their potential benefit to society and the possible risks associated with their use. Risk assessment and expected benefits will determine the future use of modified bacteria in the domains of food technology and health.

  10. Determination of the health of Lunyangwa wetland using Wetland Classification and Risk Assessment Index

    Science.gov (United States)

    Wanda, Elijah M. M.; Mamba, Bhekie B.; Msagati, Titus A. M.; Msilimba, Golden

    2016-04-01

    Wetlands are major sources of various ecological goods and services including storage and distribution of water in space and time which help in ensuring the availability of surface and groundwater throughout the year. However, there still remains a poor understanding of the range of values of water quality parameters that occur in wetlands either in its impacted state or under natural conditions. It was thus imperative to determine the health of Lunyangwa wetland in Mzuzu City in Malawi in order to classify and determine its state. This study used the Escom's Wetland Classification and Risk Assessment Index Field Guide to determine the overall characteristics of Lunyangwa wetland and to calculate its combined Wetland Index Score. Data on site information, field measurements (i.e. EC, pH, temperature and DO) and physical characteristics of Lunyangwa wetland were collected from March, 2013 to February, 2014. Results indicate that Lunyangwa wetland is a largely open water zone which is dominated by free-floating plants on the water surface, beneath surface and emergent in substrate. Furthermore, the wetland can be classified as of a C ecological category (score = 60-80%), which has been moderately modified with moderate risks of the losses and changes occurring in the natural habitat and biota in the wetland. It was observed that the moderate modification and risk were largely because of industrial, agricultural, urban/social catchment stressors on the wetland. This study recommends an integrated and sustainable management approach coupled with continuous monitoring and evaluation of the health of the wetland for all stakeholders in Mzuzu City. This would help to maintain the health of Lunyangwa wetland which is currently at risk of being further modified due to the identified catchment stressors.

  11. Health risk assessment of cadmium pollution emergency for urban populations in Foshan City, China.

    Science.gov (United States)

    Dou, Ming; Zhao, Peipei; Wang, Yanyan; Li, Guiqiu

    2017-03-01

    With rapid socioeconomic development, water pollution emergency has become increasingly common and could potentially harm the environment and human health, especially heavy metal pollution. In this paper, we investigate the Cd pollution emergency that occurred in the Pearl River network, China, in 2005, and we build a migration and transformation model for heavy metals to simulate the spatiotemporal distribution of Cd concentrations under various scenarios of Cd pollution emergency in Foshan City. Moreover, human health hazard and carcinogenic risk for local residents of Foshan City were evaluated. The primary conclusions were as follows: (1) the number of carcinogen-affected people per year under scenario 1 reached 254.41 when the frequency was 0.1 year/time; specifically, the number of people with cancer per year in the area of the Datang, Lubao, and Nanbian waterworks was 189.36 accounting for 74% of the total number per year; (2) at the frequency of 5 years/time, the Lubao waterwork is the only one in extremely high- or high-risk grade, while besides it, the risk grade in the Datang, Nanbian, Xinan, Shitang, and Jianlibao waterworks is in the extremely high or high grade when the frequency is 0.1 year/time; (3) when Cd pollution accidents with the same level occurs again, Cd concentration decreases to a low level in the water only if the migration distance of Cd is at least 40-50 km. Based on the health risk assessment of Cd pollution, this study gives the recommendation that the distance should keep above 50 km in tidal river network of the Pearl River Delta between those factories existing the possibility of heavy metal pollution and the drinking water source. Only then can the public protect themselves from hazardous effects of higher levels of heavy metal.

  12. Elucidation of endocrine disrupting mechanism of dioxin and related compounds for health risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Tohyama, Chiharu [National Institute for Environmental Studies, Tsukuba (Japan)

    2004-09-15

    The important point on health risk assessment for dioxins as well as environmental endocrine disruptors is that we should scientifically evaluate whether the actual exposure level from food and environment may pose a threat to human health not only for the present but also for the future generations. We formulated a research project, called CREST project with support from the Japan Science and Technology Agency, in order to obtain experimental evidence for risk assessment as well as for the mechanism of toxicity. We thus investigated the dose-response relationships of certain 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD)-like compounds for eliciting various endpoints. First, we administered TCDD or coplanar polychlorinated biphenyl (PCB) to rats and mice during the sensitive period from fertilization to birth. Second, we studied what kinds of adverse effects could be observed in terms of reproductive/developmental effects, cognitive/learning abilities and immune functions. Third, we focused on the actual toxicity phenotypes found at the whole body and organ/tissue levels by a forward toxicology approach, and tried to narrow down appropriate phenomena, to study the mechanism on the molecular basis by the reverse toxicology approach. In this presentation, I will summarize the outcome of the CREST project.

  13. Health Risk Assessment of Pesticide Residues via Dietary Intake of Market Vegetables from Dhaka, Bangladesh

    Directory of Open Access Journals (Sweden)

    Md. Shakhaoat Hossain

    2013-02-01

    Full Text Available The present study was designed to assess the health risk of pesticide residues via dietary intake of vegetables collected from four top agro-based markets of Dhaka, Bangladesh. High performance liquid chromatography with a photo diode array detector (HPLC-PDA was used to determine six organophosphorus (chlorpyrifos, fenitrothion, parathion, ethion, acephate, fenthion, two carbamate (carbaryl and carbofuran and one pyrethroid (cypermethrin pesticide residues in twelve samples of three common vegetables (tomato, lady’s finger and brinjal. Pesticide residues ranged from below detectable limit (<0.01 to 0.36 mg/kg. Acephate, chlorpyrifos, ethion, carbaryl and cypermethrin were detected in only one sample, while co-occurrence occurred twice for fenitrothion and parathion. Apart from chlorpyrifos in tomato and cypermethrin in brinjal, all pesticide residues exceeded the maximum residue limit (MRL. Hazard risk index (HRI for ethion (10.12 and carbaryl (1.09 was found in lady’s finger and tomato, respectively. Rest of the pesticide residues were classified as not a health risk. A continuous monitoring and strict regulation should be enforced regarding control of pesticide residues in vegetables and other food commodities.

  14. Dust-Metal Sources in an Urbanized Arid Zone: Implications for Health-Risk Assessments.

    Science.gov (United States)

    García-Rico, Leticia; Meza-Figueroa, Diana; Gandolfi, A Jay; Del Río-Salas, Rafael; Romero, Francisco M; Meza-Montenegro, Maria Mercedes

    2016-04-01

    The available information concerning metal pollution in different dust sources and the health effects in children remains limited in Mexico. This study focuses on Hermosillo, which is an urbanized area located in the Sonoran Desert in which soil resuspension and dust emission processes are common. The metal content of arsenic (As), chromium (Cr), manganese (Mn), and lead (Pb) were determined in three dust sources (playgrounds, roofs, and roads), each representing different exposure media (EM) for these elements. The metal levels in dust were found in the order of Mn > Cr > Pb > As with the highest metal content found in road dust. Despite the similar average metal distributions, principal component analysis shows a clear separation of the three EM with playground dust related to Cr and Mn and road dust to As and Pb. However, the geoaccumulation index results indicate that dust samples are uncontaminated to moderately polluted, except for Pb in road dust, which is considerably high. In addition, the enrichment factor suggests an anthropogenic origin for all of the studied metals except for Mn. In this context, the hazard index (HI) for noncarcinogenic risk is >1 in this population and thus represents a potential health risk. The spatial distribution for each metal on EM and the HI related to the marginality index could represent a more accurate decision-making tool in risk assessment studies.

  15. Impact of artificial waterfall using reclaimed water to VOCs and its health risk assessment

    Institute of Scientific and Technical Information of China (English)

    MA Jin-jun; ZHU Hong-liang; ZHAO San-ping; WANG Yong-jie; ZHU Yong-bing

    2008-01-01

    To study the impact of an artificial waterfall using reclaimed water on volatile organic compounds(VOCs) in air, air samples around the waterfall sight and over the CASS pond of a wastewater treatment plant were collected and VOCs were analyzed by MC-MS with USEPA Method TO-14. The total volatile organic com-pounds (TOVCs) concentration of a background sample is 2112μg/m3, and the sample over the CASS pond has a TVOC concentration of 1858μg/m3. The TVOC concentrations of air samples within 10 m of the artificial waterfall are between 3216μg/m3 and 6362μg/m3, which are 1.52-3.0 times that of the background sample. The VOCs in air sample impacted by reclaimed water or waste water exhibit a relatively high proportion of toluene but low proportion of benzene. B/T/E/X (Benzene/Toluene/Ethylbenzene/Xylene) ratio of the air sample around the artificial water fall is(0.36/11.78/1/1.10). Health risk assessment (HRA) was done with the USEPA four-step approach. The result indicates that the artificial waterfall using reclaimed water indeed leads to the increase of human risk value. The total risk value of the sample around the waterfall is 2.8-1.6times that of the background sample. However, the total risk value of the air sample around the waterfall (2.8×10-6) for common people is still lower, compared to the acceptable public risk level( 10-5). For occupation-al workers of the wastewater treatment plant, the sum of lifetime non-carcinogenic and carcinogenic risk values(1.26×10-5) is higher than that of the acceptable public risk level.

  16. Heavy metals bioconcentration from soil to vegetables and assessment of health risk caused by their ingestion.

    Science.gov (United States)

    Garg, V K; Yadav, Poonam; Mor, Suman; Singh, Balvinder; Pulhani, Vandana

    2014-03-01

    The present study was undertaken to assess the non-carcinogenic human health risk of heavy metals through the ingestion of locally grown and commonly used vegetables viz. Raphanus sativus (root vegetable), Daucus carota (root vegetable), Benincasa hispida (fruit vegetable) and Brassica campestris leaves (leafy vegetable) in a semi-urbanized area of Haryana state, India. Heavy metal quantification of soil and vegetable samples was done using flame atomic absorption spectrophotometer. Lead, cadmium and nickel concentration in vegetable samples varied in range of 0.12-6.54 mg kg(-1), 0.02-0.67 mg kg(-1) and vegetable samples exceeded maximum permissible limit given by World Health Organization/Food and Agriculture Organization and Indian standards. Much higher concentrations of Pb (40-190.5 mg kg(-1)), Cd (0.56-9.85 mg kg(-1)) and Ni (3.21-45.87 mg kg(-1)) were reported in corresponding vegetable fields' soils. Correlation analysis revealed the formation of three primary clusters, i.e. Cu-Cd, Cd-Pb and Ni-Zn in vegetable fields' soils further supported by cluster analysis and principal component analysis. Bioconcentration factor revealed that heavy metals' uptake was more by leafy vegetable than root and fruit vegetables. Hazard index of all the vegetables was less than unity; thus, the ingestion of these vegetables is unlikely to pose health risks to the target population.

  17. A decision support system for drinking water production integrating health risks assessment.

    Science.gov (United States)

    Delpla, Ianis; Monteith, Donald T; Freeman, Chris; Haftka, Joris; Hermens, Joop; Jones, Timothy G; Baurès, Estelle; Jung, Aude-Valérie; Thomas, Olivier

    2014-07-18

    The issue of drinking water quality compliance in small and medium scale water services is of paramount importance in relation to the 98/83/CE European Drinking Water Directive (DWD). Additionally, concerns are being expressed over the implementation of the DWD with respect to possible impacts on water quality from forecast changes in European climate with global warming and further anticipated reductions in north European acid emissions. Consequently, we have developed a decision support system (DSS) named ARTEM-WQ (AwaReness Tool for the Evaluation and Mitigation of drinking Water Quality issues resulting from environmental changes) to support decision making by small and medium plant operators and other water stakeholders. ARTEM-WQ is based on a sequential risk analysis approach that includes consideration of catchment characteristics, climatic conditions and treatment operations. It provides a holistic evaluation of the water system, while also assessing human health risks of organic contaminants potentially present in treated waters (steroids, pharmaceuticals, pesticides, bisphenol-a, polychlorobiphenyls, polycyclic aromatic hydrocarbons, petrochemical hydrocarbons and disinfection by-products; n = 109). Moreover, the system provides recommendations for improvement while supporting decision making in its widest context. The tool has been tested on various European catchments and shows a promising potential to inform water managers of risks and appropriate mitigative actions. Further improvements should include toxicological knowledge advancement, environmental background pollutant concentrations and the assessment of the impact of distribution systems on water quality variation.

  18. Human health risk assessment of nitrosamines and nitramines for potential application in CO2 capture.

    Science.gov (United States)

    Ravnum, S; Rundén-Pran, E; Fjellsbø, L M; Dusinska, M

    2014-07-01

    Emission and accumulation of carbon dioxide (CO2) in the atmosphere exert an environmental and climate change challenge. An attempt to deal with this challenge is made at Mongstad by application of amines for CO2 capture and storage (CO2 capture Mongstad (CCM) project). As part of the CO2 capture process, nitrosamines and nitramines may be emitted. Toxicological testing of nitrosamines and nitramines indicate a genotoxic potential of these substances. Here we present a risk characterization and assessment for five nitrosamines (N-Nitrosodi-methylamine (NDMA) N-Nitrosodi-ethylamine (NDEA), N-Nitroso-morpholine (NNM), N-Nitroso-piperidine (NPIP), and Dinitroso-piperazine (DNP)) and two nitramines (N-Methyl-nitramine (NTMA), Dimethyl-nitramine (NDTMA)), which are potentially emitted from the CO2 capture plant (CCP). Human health risk assessment of genotoxic non-threshold substances is a heavily debated topic, and no consensus methodology exists internationally. Extrapolation modeling from high-dose animal exposures to low-dose human exposures can be crucial for the final risk calculation. In the work presented here, different extrapolation models are discussed, and suggestions on applications are given. Then, preferred methods for calculating derived minimal effect level (DMEL) are presented with the selected nitrosamines and nitramines.

  19. A Decision Support System for Drinking Water Production Integrating Health Risks Assessment

    Directory of Open Access Journals (Sweden)

    Ianis Delpla

    2014-07-01

    Full Text Available The issue of drinking water quality compliance in small and medium scale water services is of paramount importance in relation to the 98/83/CE European Drinking Water Directive (DWD. Additionally, concerns are being expressed over the implementation of the DWD with respect to possible impacts on water quality from forecast changes in European climate with global warming and further anticipated reductions in north European acid emissions. Consequently, we have developed a decision support system (DSS named ARTEM-WQ (AwaReness Tool for the Evaluation and Mitigation of drinking Water Quality issues resulting from environmental changes to support decision making by small and medium plant operators and other water stakeholders. ARTEM-WQ is based on a sequential risk analysis approach that includes consideration of catchment characteristics, climatic conditions and treatment operations. It provides a holistic evaluation of the water system, while also assessing human health risks of organic contaminants potentially present in treated waters (steroids, pharmaceuticals, pesticides, bisphenol-a, polychlorobiphenyls, polycyclic aromatic hydrocarbons, petrochemical hydrocarbons and disinfection by-products; n = 109. Moreover, the system provides recommendations for improvement while supporting decision making in its widest context. The tool has been tested on various European catchments and shows a promising potential to inform water managers of risks and appropriate mitigative actions. Further improvements should include toxicological knowledge advancement, environmental background pollutant concentrations and the assessment of the impact of distribution systems on water quality variation.

  20. Urban flooding and health risk analysis by use of quantitative microbial risk assessment

    DEFF Research Database (Denmark)

    Andersen, Signe Tanja

    according to location, as demonstrated for microbial, chemical and physical parameters between sub-catchments. Variations in wastewater quality, as well as rainfall, system and environmental effects (solar radiation), cause knock-on variations in floodwater composition, because they are functions...... of these parameters. Variations between locations have been demonstrated through measurements of microbial concentrations in flooding episodes, while changes in microbial concentrations over time have been demonstrated through a survival and decay study, where decay was substantial in the presence of UV light......, the drainage model was validated by comparison of modelled and measured microbial concentrations in CSOs. The model result was used in the analysis of the risk of infection from exposure to urban flooding which resulted in a risk of 10.3 to 10-1 from exposure to flooding, both from cleaning up flooding...

  1. Hygienic assessment of drinking water quality and risks to public health in Krasnoyarsk region

    Directory of Open Access Journals (Sweden)

    D.V. Goryaev

    2016-09-01

    Full Text Available The article presents the hygienic assessment of water quality in water sources of the Krasnoyarsk region used for centralized drinking water supply. It is shown that the exceeding of hygienic standards was registered at such indicators as iron (iron content is noted at the level to 1.8 mg/dm 3 or 6 MPC; fluorine (up to 6 MPC; ammonia and ammonium nitrogen (up to 2 MPC, nitrates (up to 5 MPC, organochlorine compounds (chloroform, carbon tetrachloride up to 5 MPC, manganese (up to 5.5 MPC, aluminium (up to 2 MPC. In water carcinogenic contaminants are recorded in significant concentrations: benzo(apyrene, cadmium, arsenic, nickel, lead. It is determined that the total lifetime carcinogenic risk to public health in the cities and districts of the Krasnoyarsk region due to oral intake from drinking water of chemicals of carcinogenic nature is negligible in 22 areas, and requires no additional measures to reduce. 23 territories of the region have carcinogenic risk ranged 1.0E-6 to 1.0E-5, which meets the criteria of acceptable risk. 9 territories (the town of Borodino, Lesosibirsk, Yeniseisk, Kazachinskiy, Partizansky, Pirovskiy, Rybinskiy, Sayanskiy, Uyarskiy areas show the level of lifetime individual cancer risk from 1.0E-5 to 2.0E-4, which is unacceptable for the population in general. The main contribution to the risk level (80.8–98.4 % makes the contents of arsenic in the drinking water. There is an increased risk of district (NI=1.2 and NI=1.17, respectively; bone and teeth from residents of the Sukhobuzimsky district (NI=1.04. High hazard indexes due to the nitrate and fluoride. Providing the population of urban districts and municipal districts of the Krasnoyarsk region with safe drinking water requires a set of various measures with the development and implementation of programs on improvement of water supply of populated areas

  2. Risk assessment and cost-effectiveness of animal health certification methods for livestock export in Somalia.

    Science.gov (United States)

    Knight-Jones, T J D; Njeumi, F; Elsawalhy, A; Wabacha, J; Rushton, J

    2014-03-01

    Livestock export is vital to the Somali economy. To protect Somali livestock exports from costly import bans used to control the international spread of disease, better certification of livestock health status is required. We performed quantitative risk assessment and cost-effectiveness analysis on different health certification protocols for Somali livestock exports for six transboundary diseases. Examining stock at regional markets alone without port inspection and quarantine was inexpensive but was ineffective for all but contagious bovine pleuropneumonia, contagious caprine pleuropneumonia and peste des petits ruminants. While extended pre-export quarantine improves detection of infections that cause clinical disease, if biosecurity is suboptimal quarantine provides an opportunity for transmission and increased risk. Clinical examination, laboratory screening and vaccination of animals for key diseases before entry to the quarantine station reduced the risk of an exported animal being infected. If vaccination could be reliably performed weeks before arrival at quarantine its effect would be greatly enhanced. The optimal certification method depends on the disease. Laboratory diagnostic testing was particularly important for detecting infections with limited clinical signs in male animals (only males are exported); for Rift Valley fever (RVF) the probability of detection was 99% or 0% with and without testing. Based on our findings animal inspection and certification at regional markets combined with quarantine inspection and certification would reduce the risk of exporting infected animals and enhance disease control at the regional level. This is especially so for key priority diseases, that is RVF, foot-and-mouth disease and Brucellosis. Increased data collection and testing should be applied at point of production and export.

  3. Risk of completed suicide in 89,049 young males assessed by a mental health professional.

    Science.gov (United States)

    Weiser, Mark; Goldberg, Shira; Werbeloff, Nomi; Fenchel, Daphna; Reichenberg, Abraham; Shelef, Leah; Large, Matthew; Davidson, Michael; Fruchter, Eyal

    2016-02-01

    In an individual who seeks help or is referred to a mental health professional it is common sense and clinical practice to assume that suicidal thoughts and previous attempts constitute risk factors for imminent suicide. However, this assumption has not been supported by large, population-based longitudinal studies. The current study investigated whether reports of current suicidal ideation and a history of suicide attempts indeed increase risk for later completed suicide in a historical prospective study design. Sequential records on 89,049 young males assessed by mental health professionals were screened for suicidal ideation and a history of suicide attempts. The data were linked with death records from the Israeli Central Bureau of Statistics. Over a follow-up period ranging from 2 months to 9.8 years, 54 individuals died by suicide, constituting an average suicide rate of 6.48 per 100,000 person-years. Overall, neither reporting current suicidal ideation (without a history of suicide attempts; HR=1.29, 95% CI=0.57-2.90) nor reporting a history of suicide attempts (with or without current suicidal ideation; HR=1.67, 95% CI=0.71-3.97) were significantly associated with increased risk for later completed suicide. However, young males with a previously diagnosed psychiatric disorder who reported current suicidal ideation (HR=4.52, 95% CI=1.08-18.91) or a history of suicide attempts (HR=6.43, 95% CI=1.54-26.90) were at increased risk of death by suicide. These findings indicate that in this particular population reports of current suicidal ideation or of a history of suicide attempts are helpful in predicting future suicide only among those with a previous diagnosis of a psychiatric disorder.

  4. Exposure to toxicants in soil and bottom ash deposits in Agbogbloshie, Ghana: human health risk assessment.

    Science.gov (United States)

    Obiri, S; Ansa-Asare, O D; Mohammed, S; Darko, H F; Dartey, A G

    2016-10-01

    Recycling of e-waste using informal or crude techniques poses serious health risk not only to the workers but also to the environment as whole. It is against this background that this paper sought to measure health risk faced by informal e-waste workers from exposure to toxicants such as lead, cadmium, chromium, copper, arsenic, tin, zinc and cobalt via oral and dermal contact with bottom ash and soil. Using random sampling techniques, 3 separate sites each (where burning and manual dismantling of e-wastes are usually carried) were identified, and a total of 402 samples were collected. The samples were analysed using standard methods for chemical analysis prescribed by the American Water Works Association (AWWA). Concentrations of Pb, Cd, Cr, Cu, As, Sn, Zn and Co in bottom ash samples from location ASH1 are 5388 ± 0.02 mg/kg (Pb), 2.39 ± 0.01 mg/kg (Cd), 42 ± 0.05 mg/kg (Cr), 7940 ± 0.01 mg/kg (Cu), 20 ± 0.07 mg/kg (As), 225 ± 0.04 mg/kg (Sn), 276 ± 0.04 mg/kg (Zn) and 123 ± 0.04 mg/kg (Co), while concentrations of the aforementioned toxicants in soil samples at location ASG1 are as follows: 1685 ± 0.14 mg/kg (Pb), 26.89 ± 0.30 mg/kg (Cd), 36.86 ± 0.02 mg/kg (Cr), 1427 ± 0.08 mg/kg (Cu), 1622 ± 0.12 mg/kg (As), 234 ± 0.25 mg/kg (Sn), 783 ± 0.31 mg/kg (Zn) and 135 ± 0.01 mg/kg (Co); used as input parameters in assessing health risk faced by workers. The results of cancer health risk faced by e-waste workers due to accidental ingestion of As in bottom ash at ASH1 is 4.3 × 10(-3) (CTE) and 6.5 × 10(-2) (RME), i.e. approximately 4 out of 1000 e-waste workers are likely to suffer from cancer-related diseases via central tendency exposure (CTE parameters), and 7 out of every 100 e-waste worker is also likely to suffer from cancer cases by reasonable maximum exposure (RME) parameters, respectively. The cancer health risk results for the other sampling sites were found to have exceeded the acceptable

  5. Documentary analysis of risk-assessment and safety-planning policies and tools in a mental health context.

    Science.gov (United States)

    Higgins, Agnes; Doyle, Louise; Morrissey, Jean; Downes, Carmel; Gill, Ailish; Bailey, Sive

    2016-08-01

    Despite the articulated need for policies and processes to guide risk assessment and safety planning, limited guidance exists on the processes or procedures to be used to develop such policies, and there is no body of research that examines the quality or content of the risk-management policies developed. The aim of the present study was to analyse the policies of risk and safety management used to guide mental health nursing practice in Ireland. A documentary analysis was performed on 123 documents received from 22 of the 23 directors of nursing contacted. Findings from the analysis revealed a wide variation in how risk, risk assessment, and risk management were defined. Emphasis within the risk documentation submitted was on risk related to self and others, with minimal attention paid to other types of risks. In addition, there was limited evidence of recovery-focused approaches to positive risk taking that involved service users and their families within the risk-related documentation. Many of the risk-assessment tools had not been validated, and lacked consistency or guidance in relation to how they were to be used or applied. The tick-box approach and absence of space for commentary within documentation have the potential to impact severely on the quality of information collected and documented, and subsequent clinical decision-making. Managers, and those tasked with ensuring safety and quality, need to ensure that policies and processes are, where possible, informed by best evidence and are in line with national mental health policy on recovery.

  6. Estrogenic endocrine disruptors present in sports supplements. A risk assessment for human health.

    Science.gov (United States)

    Plotan, Monika; Elliott, Christopher T; Frizzell, Caroline; Connolly, Lisa

    2014-09-15

    Sports supplements are becoming a regular dietary addition for consumers who view such products as a means of improving their health and performance. Previously estrogenic endocrine disruptors (EDs) were detected in 80% of 116 sports supplements investigated by biological in vitro reporter gene assays (RGAs). The aim of this study was to quantify the hormonal activity in 50 of these sports supplement samples using a validated estrogen RGA and perform an exposure and risk assessment for human health. Results showed that 17β-estradiol equivalent levels were higher than those reported as being present in the typical human omnivore diet in 33 of the sports supplements and higher than the acceptable daily intake (ADI) in 13 of these products. The highest activity samples presented a potential to influence the human daily exposure to 17β-estradiol like activity in various risk groups with a predicted hormonal impact of greatest concern in young boys and postmenopausal women. In conclusion, consumers of sports supplements may be exposed to high levels of estrogenic EDs.

  7. Human health risk assessment of heavy metals in cosmetics in Nigeria.

    Science.gov (United States)

    Nduka, John K; Odiba; Orisakwe, Orish E; Ukaebgu, Linda D; Sokaibe, Chinwetuto; Udowelle, Nnaemeka A

    2015-01-01

    Forty two different cosmetics were purchased from supermarkets and cosmetic shops within Unitsha Main Market and Eke-Awka markets in Anambra, Nigeria. Of the cosmetics, 16% were locally manufactured in Nigeria while 83.33% were imported into Nigeria. The cosmetics were ashed before digestion and filtration. The filtrates were assayed for lead, cadmium, manganese, nickel, chromium, mercury, and arsenic with atomic absorption spectrophotometry at 205 Å. The health risk assessment methods developed by the United States Environmental Protection Agency were employed to explore the potential human health risk of heavy metals in cosmetics. About 61.91% of the cosmetic samples contained lead with concentration in the range of 0.10-42.12 mg/kg. Cadmium levels of the cosmetics ranged from 0.01 to 1.32 mg/kg, manganese from 0.02 to 67.65 mg/kg, nickel from 0.05 to 17.34 mg/kg, chromium from 0.11 to 9.81 mg/kg, mercury from 0.003 to 0.07 mg/kg, and arsenic from 0.002 to 0.005 mg/kg. Although the target hazard quotients and the hazard indices suggest a measure of safety, cosmetics may add to the body burden of potential toxic metals after chronic exposure.

  8. Urinary antibiotics of pregnant women in Eastern China and cumulative health risk assessment.

    Science.gov (United States)

    Wang, Hexing; Wang, Na; Qian, Junhua; Hu, Lingyun; Huang, Peixin; Su, Meifang; Yu, Xin; Fu, Chaowei; Jiang, Feng; Zhao, Qi; Zhou, Ying; Lin, Haijiang; He, Gengsheng; Chen, Yue; Jiang, Qingwu

    2017-02-23

    Exposure to antibiotics during pregnancy can pose a systematic effect on human health. A few bio-monitoring studies have demonstrated an extensive exposure of children to antibiotics, but there is still lack of data for pregnant women. To assess the exposure of pregnant women to antibiotics and potential health risk, we investigated 536 pregnant women aged 16-42 years from two geographically different study sites in Eastern China in 2015. We measured 21 antibiotics of five categories (seven fluoroquinolones, three phenicols, four tetracyclines, three macrolides, and four sulfonamides) in urines by using the isotope dilution ultra-performance liquid chromatography coupled to quadrupole time of-flight mass spectrometry. Hazard index (HI) was calculated based on estimated daily exposure dose and acceptable daily intakes. Sixteen antibiotics were found in urines with detection frequencies between 0.2% and 16.0%. Antibiotics were overall detected in 41.6% of urines, and two or more antibiotics were detected in 13.1% of urines. Ciprofloxacin, ofloxacin, and trimethoprim were most frequently detected in urine with detection frequencies between 10% and 20%. The majority of the antibiotics tested had an estimated daily exposure dose less than 1μg/kg/day and 4.3% of pregnant women had a HI value more than one. These findings indicated that pregnant women were frequently exposed to antibiotics and some individuals were in the potential risk of adverse microbiological effects induced by antibiotics.

  9. Assessment of the BTEX concentrations and health risk in urban nursery schools in Gliwice, Poland

    Directory of Open Access Journals (Sweden)

    Anna Mainka

    2016-12-01

    Full Text Available Indoor air quality (IAQ in nursery school is believed to be different from elementary school. Moreover, younger children are more vulnerable to air pollution than higher grade children because they spend more time indoors, and their immune systems and bodies are less mature. The purpose of this study was to compare the concentrations of the monoaromatic volatile benzene, toluene, ethylbenzene m,p-xylene and o-xylene (BTEX in urban nursery schools located in Gliwice, Poland. The nursery schools were chosen to include areas with different urbanization and traffic density characteristics in order to gather a more diverse picture of exposure risks in the various regions of the city. BTEX were sampled during winter and spring seasons in older and younger children classrooms. The samples were thermally desorbed (TD and then analyzed with use of gas chromatography (GC. In addition, outdoor measurements were carried out in the playground at each nursery school. BTEX quantification, indoor/outdoor concentration, and correlation coefficients were used to identify pollutant sources. Elevated levels of o-xylene and ethylbenzene were found in all monitored classrooms during the winter season. Outdoor concentrations were lower than indoors for each classroom. Indicators based on health risk assessment for chronic health effects associated with carcinogenic benzene or non-carcinogenic BTEX were proposed to rank sites according to their hazard level.

  10. Effect of health risk assessment and counselling on health behaviour and survival in older people: a pragmatic randomised trial.

    Directory of Open Access Journals (Sweden)

    Andreas E Stuck

    2015-10-01

    Full Text Available Potentially avoidable risk factors continue to cause unnecessary disability and premature death in older people. Health risk assessment (HRA, a method successfully used in working-age populations, is a promising method for cost-effective health promotion and preventive care in older individuals, but the long-term effects of this approach are unknown. The objective of this study was to evaluate the effects of an innovative approach to HRA and counselling in older individuals for health behaviours, preventive care, and long-term survival.This study was a pragmatic, single-centre randomised controlled clinical trial in community-dwelling individuals aged 65 y or older registered with one of 19 primary care physician (PCP practices in a mixed rural and urban area in Switzerland. From November 2000 to January 2002, 874 participants were randomly allocated to the intervention and 1,410 to usual care. The intervention consisted of HRA based on self-administered questionnaires and individualised computer-generated feedback reports, combined with nurse and PCP counselling over a 2-y period. Primary outcomes were health behaviours and preventive care use at 2 y and all-cause mortality at 8 y. At baseline, participants in the intervention group had a mean ± standard deviation of 6.9 ± 3.7 risk factors (including unfavourable health behaviours, health and functional impairments, and social risk factors and 4.3 ± 1.8 deficits in recommended preventive care. At 2 y, favourable health behaviours and use of preventive care were more frequent in the intervention than in the control group (based on z-statistics from generalised estimating equation models. For example, 70% compared to 62% were physically active (odds ratio 1.43, 95% CI 1.16-1.77, p = 0.001, and 66% compared to 59% had influenza vaccinations in the past year (odds ratio 1.35, 95% CI 1.09-1.66, p = 0.005. At 8 y, based on an intention-to-treat analysis, the estimated proportion alive was 77.9% in

  11. Phase 1 data summary report for the Clinch River Remedial Investigation: Health risk and ecological risk screening assessment

    Energy Technology Data Exchange (ETDEWEB)

    Cook, R.B.; Adams, S.M.; Beauchamp, J.J.; Bevelhimer, M.S.; Blaylock, B.G.; Brandt, C.C.; Ford, C.J.; Frank, M.L.; Gentry, M.J.; Holladay, S.K.; Hook, L.A.; Levine, D.A.; Longman, R.C.; McGinn, C.W.; Skiles, J.L.; Suter, G.W.; Williams, L.F.

    1992-12-01

    The Clinch River Remedial Investigation (CRRI) is designed to address the transport, fate, and distribution of waterborne contaminants released from the US Department of Energy's (DOE's) Oak Ridge Reservation (ORR) and to assess potential risks to human health and the environment associated with these contaminants. The contaminants released since the early 1940s include a variety of radionuclides, metals, and organic compounds. The purpose of this report is to summarize the results of Phase 1 of the CRRI. Phase 1 was designed to (1) obtain high-quality data to confirm existing historical data for contaminant levels in fish, sediment, and water from the CR/WBR; (2) determine the in the range of contaminant concentrations present river-reservoir system; (3) identify specific contaminants of concern; and (4) establish the reference (background) concentrations for those contaminants.

  12. Bioaccumulation of heavy metals in mollusca species and assessment of potential risks to human health.

    Science.gov (United States)

    Abdallah, Maha Ahmed Mohamed

    2013-05-01

    Along the Alexandria coast of the Egyptian Mediterranean Sea, five edible species of bivalve molluscs and one gastropoda species (Mactra coralline, Ruditapes decussates, Paphia undulate, Venerupis rhomboids, Crista pectinata and Coralliophila meyendorffi) were analyzed for content of metals (Cadmium, Chromium, Lead, Cobalt and Nickel) in the muscle and in the sediments where they live. The potential health risks of metals to humans via consumption of seafood were assessed by estimated daily intake and target hazard quotient. Significant positive correlations (p < 0.05) were obtained between tissue concentrations for all pairs of metals, with the exception of Cadmium. Significant positive correlations were also obtained for the concentrations of Cd and Ni in tissues of all studied species relative to their concentrations in surface sediments. However, correlations between tissue and sediment concentrations for Chromium, Lead and Cobalt were negative. Ruditapes decussates and C. meyendorffi had the highest values for the summed target hazard quotient and may pose a potential risk to local inhabitants through their consumption in the diet. The potential risk would arise from exposure to high tissue concentrations of Cd and Pb, which exceeded published guidelines for safety of seafood products in some cases. Chromium contributed a considerable fraction of the total target hazard quotient for all metals combined, but did not exceed the published guidelines. Cobalt and Ni did not contribute greatly overall to the target hazard quotient, except in the case of Ni in V. rhomboids.

  13. Cadmium and lead in seafood from the Aratu Bay, Brazil and the human health risk assessment.

    Science.gov (United States)

    Silva da Araújo, Cecilia Freitas; Lopes, Mariângela Vieira; Vaz Ribeiro, Mirian Rocha; Porcino, Thiago Santos; Vaz Ribeiro, Amanda Santos; Rodrigues, Juliana Lima Gomes; do Prado Oliveira, Sérgio Soares; Menezes-Filho, José Antonio

    2016-04-01

    This study aimed to evaluate cadmium (Cd) and lead (Pb) levels in seafood and perform a risk assessment based on individual food consumption frequency of inhabitants of the Aratu Bay, Brazil. From December 2013 to November 2014, ready-to-market seafood, including fish [pititinga (Lile piquitinga) and small green eel (Gobionellus oceanicus)], mollusks [mussel (Mytella guyanensis) and oyster (Crassostrea rhizophorae)], and crustaceans [white shrimp (Litopenaeus schmitti) and blue crab (Callinectes exasperatus)], were purchased bimonthly from a local artisanal shellfish harvester. Metal levels were analyzed by graphite furnace atomic absorption spectrometry (GFAAS). Based on the volunteer’ seafood consumption, estimates of the non-carcinogenic target hazard quotients (THQs) were calculated. The annual concentrations (μg/g, w/w) of Cd were 0.007 (±0.001) in crustaceans, 0.001 (±0.0003) in fish, and 0.446 (±0.034) in mollusks. Lead levels were fish, and 0.111 (±0.009) in mollusks. All values were within the international guidelines. We observed that 90.9 % of the responders presented an average THQ < 1, which is classified as negligible risk; however, 9.1 % presented THQs between ≥1 and <9.9. These data are important to inform the community of the imminent exposure risk through communication strategies, with the purpose of minimizing exposure and, consequently, the health effects associated with it.

  14. Integrated frameworks for assessing and managing health risks in the context of managed aquifer recharge with river water.

    Science.gov (United States)

    Assmuth, Timo; Simola, Antti; Pitkänen, Tarja; Lyytimäki, Jari; Huttula, Timo

    2016-01-01

    Integrated assessment and management of water resources for the supply of potable water is increasingly important in light of projected water scarcity in many parts of the world. This article develops frameworks for regional-level waterborne human health risk assessment of chemical and microbiological contamination to aid water management, incorporating economic aspects of health risks. Managed aquifer recharge with surface water from a river in Southern Finland is used as an illustrative case. With a starting point in watershed governance, stakeholder concerns, and value-at-risk concepts, we merge common methods for integrative health risk analysis of contaminants to describe risks and impacts dynamically and broadly. This involves structuring analyses along the risk chain: sources-releases-environmental transport and fate-exposures-health effects-socio-economic impacts-management responses. Risks attributed to contaminants are embedded in other risks, such as contaminants from other sources, and related to benefits from improved water quality. A set of models along this risk chain in the case is presented. Fundamental issues in the assessment are identified, including 1) framing of risks, scenarios, and choices; 2) interaction of models and empirical information; 3) time dimension; 4) distributions of risks and benefits; and 5) uncertainties about risks and controls. We find that all these combine objective and subjective aspects, and involve value judgments and policy choices. We conclude with proposals for overcoming conceptual and functional divides and lock-ins to improve modeling, assessment, and management of complex water supply schemes, especially by reflective solution-oriented interdisciplinary and multi-actor deliberation.

  15. Evaluation of the public health impacts of traffic congestion: a health risk assessment

    Directory of Open Access Journals (Sweden)

    Buonocore Jonathan J

    2010-10-01

    Full Text Available Abstract Background Traffic congestion is a significant issue in urban areas in the United States and around the world. Previous analyses have estimated the economic costs of congestion, related to fuel and time wasted, but few have quantified the public health impacts or determined how these impacts compare in magnitude to the economic costs. Moreover, the relative magnitudes of economic and public health impacts of congestion would be expected to vary significantly across urban areas, as a function of road infrastructure, population density, and atmospheric conditions influencing pollutant formation, but this variability has not been explored. Methods In this study, we evaluate the public health impacts of ambient exposures to fine particulate matter (PM2.5 concentrations associated with a business-as-usual scenario of predicted traffic congestion. We evaluate 83 individual urban areas using traffic demand models to estimate the degree of congestion in each area from 2000 to 2030. We link traffic volume and speed data with the MOBILE6 model to characterize emissions of PM2.5 and particle precursors attributable to congestion, and we use a source-receptor matrix to evaluate the impact of these emissions on ambient PM2.5 concentrations. Marginal concentration changes are related to a concentration-response function for mortality, with a value of statistical life approach used to monetize the impacts. Results We estimate that the monetized value of PM2.5-related mortality attributable to congestion in these 83 cities in 2000 was approximately $31 billion (2007 dollars, as compared with a value of time and fuel wasted of $60 billion. In future years, the economic impacts grow (to over $100 billion in 2030 while the public health impacts decrease to $13 billion in 2020 before increasing to $17 billion in 2030, given increasing population and congestion but lower emissions per vehicle. Across cities and years, the public health impacts range from

  16. Health risk of low-dose pesticides mixtures: a review of the 1985-1998 literature on combination toxicology and health risk assessment.

    Science.gov (United States)

    Carpy, S A; Kobel, W; Doe, J

    2000-01-01

    A literature review covering the last 14 yr has been performed in the field of combination toxicology and human risk assessment from exposure to chemical mixtures, with special emphasis on mixtures of pesticides at low doses, that is, at levels likely to occur in human diet and environment. Despite a large body of knowledge in the field of risk assessment methodologies for exposure to chemical and pesticide mixtures, there is no single methodological approach in "combination toxicology" and health risk assessment of chemical mixtures, and therefore professional judgment is still required. Generally, the dose or response additivity approach that may be applied to evaluate potential risk for chemical mixtures in human toxicology overestimates the risk of a combination of chemicals. The recent endocrine disrupter issue demonstrated the difficulty of reproducibility of data when testing environmental toxicants at very low levels, and the need for more basic work in this field. The use of integrated methodological approaches may provide more reliable predictive data in the risk assessment of chemical mixtures in future. Yet data have demonstrated that exposure to a combination of compounds does not cause effects stronger than the ones of their most active component, provided components are present at low concentration levels, like acceptable daily intake (ADI) or reference dose (RfD) levels, well below their respective no-observed-adverse-effect levels (NOAELs). Although it has been demonstrated that a combination of compounds with the same target organ and the same or very similar mechanisms of action may cause additive or synergistic effects, the chance of such effects will most likely diminish with decreasing exposure levels to such combinations. Synergism and antagonism may both occur at the same time at different organs or targets in the same organism. However, and despite some exceptions, it has been demonstrated that interaction between components is not a common

  17. CADMIUM IN OCTOPUS VULGARIS: AN INPUT TO ASSESS HUMAN HEALTH RISK

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    E. Ceci

    2009-12-01

    Full Text Available Cadmium concentrations has been evaluated in Octopus vulgaris sampled from two sites of Apulian coast (South Italy and compared with import cephalopods to estimate if maximum levels of cadmium established for these organisms by the European Commission were exceed. In all local samples mean cadmium concentrations were higher in hepatopancreas than in flesh, this is an important evaluation if consider the traditional and unusual consumption in certain population of Mediterranean region of raw and whole cephalopods. The cadmium estimated weekly intake for whole cephalopods between 2,25 and 2,84 g Kg -1 of body weight underlines the necessity to determine the real risk and implications for public health through a correct assessment of contribution made by this specie among certain consumers group to the TWI set by the EFSA. A particular attention from competent authorities to prevent human toxicity is required.

  18. Probabilistic Health Risk Assessment of Chemical Mixtures: Importance of Travel Times and Connectivity

    Science.gov (United States)

    Henri, Christopher V.; Fernàndez-Garcia, Daniel; de Barros, Felipe P. J.

    2014-05-01

    Subsurface contamination cases giving rise to groundwater pollutions are extensively found in all industrialized countries. Under this pressure, risk assessment methods play an important role in population protection by (1) quantifying the potential impact on human health of an aquifer contamination and (2) helping and driving decisions of groundwater-resource managers. Many reactive components such as chlorinated solvents or nitrates potentially experience attenuation processes under common geochemical conditions. This represents an attractive and extensively used remediation solution but leads often to the production of by-products before to reach a harmless chemical form. This renders mixtures of contaminants a common issue for groundwater resources managers. In this case, the threat posed by these contaminants to human health at a given sensitive location greatly depends on the competition between reactive and advective-dispersive characteristic times. However, hydraulic properties of the aquifer are known to be spatially variable, which can lead to the formation of preferential flow channels and fast contamination pathways. Therefore, the uncertainty on the spatial distribution of the aquifer properties controlling the plume travel time may then play a particular role in the human health risk assessment of chemical mixtures. We investigate here the risk related to a multispecies system in response to different degrees of heterogeneity of the hydraulic conductivity (K or Y =ln(K)). This work focuses on a Perchloroethylene (PCE) contamination problem followed by the sequential first-order production/biodegradation of its daughter species Trichloroethylene (TCE), Dichloroethylene (DCE) and Vinyl Chlorine (VC). For this specific case, VC is known to be a highly toxic contaminant. By performing numerical experiments, we evaluate transport through three-dimensional mildly (σY 2=1.0) and highly (σY 2=4.0) heterogeneous aquifers. Uncertainty on the hydraulic

  19. Health Risk Assessment for Transport Corridors in Delhi through Vehicular Air Polluting Mapping

    Directory of Open Access Journals (Sweden)

    Nitin Kumar

    2016-09-01

    Full Text Available Vehicles are recognized as one of the major sources of air pollution. Delhi having  a very large number of vehicles produces a lot of air pollution. There is an utter need to ascertain the concentration of the pollutants and their impact on the health of the people of the concerned region. This paper makes an attempt towards such an examination. The method employed here is based on Epidemiology. The assessment of health risks due to increased levels of various pollutants on people represented in this paper is based on the spreadsheet model, Risk of Mortality/Morbidity due to Air Pollution (Ri–MAP. This paper presents the findings of the study that evaluates the Impact of increasing air pollution on human health, especially vehicular pollution, in the monitored region, i.e., National Capital Territory of Delhi (NCT Delhi during the year 2015 by choosing fifteen study sites from different parts of the capital city. The findings are in terms of  excess number of cases of cardiovascular and respiratory mortality, and cardiovascular and respiratory morbidity for all fifteen transport corridors. Among others, Noida link road recorded highest excess number of cases of cardiovascular mortality and morbidity and respiratory Morbidity. In case of respiratory mortality, Wazirabad road recorded maximum excess number of cases. With respect to least excess number of cases, it was Connaught Place (Outer circle. The excess number of cases are directly proportional to the population density of the respective region. Also, the regions showing smaller excess number of cases are the planned, less crowded and posh regions of the national capital territory of Delhi.

  20. Risk assessment of coccidostatics during feed cross-contamination: Animal and human health aspects

    Energy Technology Data Exchange (ETDEWEB)

    Dorne, J.L.C.M., E-mail: jean-lou.dorne@efsa.europa.eu [European Food Safety Authority, Unit on Contaminants in the Food Chain, Parma (Italy); Fernández-Cruz, M.L. [Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Madrid (Spain); Bertelsen, U. [European Food Safety Authority, Unit on Contaminants in the Food Chain, Parma (Italy); Renshaw, D.W. [Food Standards Agency, London (United Kingdom); Peltonen, K. [Finnish Food Safety Authority, EVIRA, Helsinki (Finland); Anadon, A. [Universidad Complutense de Madrid, Facultad de Veterinaria, Madrid (Spain); Feil, A. [ForschungsinstitutFuttermitteltechnik, Braunschweig (Germany); Sanders, P. [AFSSA, LERMVD, Fougères (France); Wester, P. [RIVM, Food and Consumer Safety, Bilthoven (Netherlands); Fink-Gremmels, J. [Utrecht University, Veterinary Medicine, Utrecht (Netherlands)

    2013-08-01

    Coccidiosis, an intestinal plasmodium infection, is a major infectious disease in poultry and rabbits. Eleven different coccidiostats are licensed in the EU for the prevention of coccidiosis in these animal species. According to their chemical nature and main biological activity, these compounds can be grouped as ionophoric (monensin, lasalocid sodium, salinomycin, narasin, maduramicin and semduramicin) or non-ionophoric (robenidine, decoquinate, nicarbazin, diclazuril, and halofuginone) substances. Coccidiostats are used as feed additives, mixed upon request into the compounded feed. During the technical process of commercial feed production, cross-contamination of feed batches can result in the exposure of non-target animals and induce adverse health effects in these animals due to a specific sensitivity of mammalian species as compared to poultry. Residue formation in edible tissues of non-target species may result in unexpected human exposure through the consumption of animal products. This review presents recent risk assessments performed by the Scientific Panel on Contaminants in the Food Chain (CONTAM) of the European Food Safety Authority (EFSA). The health risk to non-target species that would result from the consumption of cross-contaminated feed with coccidostats at levels of 2, 5 or 10% was found to be negligible for most animal species with the exception of salinomycin and monensin in horses because of the particular sensitivity for which toxicity may occur when cross-contamination exceeds 2% and 5% respectively. Kinetic data and tissue analyses showed that residues of coccidiostats may occur in the liver and eggs in some cases. However, the level of residues of each coccidiostat in edible animal tissues remained sufficiently low that the aggregate exposure of consumers would not exceed the established acceptable daily intake (ADI) of each coccidiostat. It could be concluded that technical cross-contamination of animal feeds would not be expected to

  1. Falls risk assessment begins with hello: lessons learned from the use of one home health agency's fall risk tool.

    Science.gov (United States)

    Flemming, Patricia J; Ramsay, Katherine

    2012-10-01

    Identifying older adults at risk for falls is a challenge all home healthcare agencies (HHAs) face. The process of assessing for falls risk begins with the initial home visit. One HHA affiliated with an academic medical center describes its experience in development and use of a Falls Risk Assessment (FRA) tool over a 10-year period. The FRA tool has been modified since initial development to clarify elements of the tool based on research and to reflect changes in the Outcome and Assessment Information Set (OASIS) document. The primary purpose of this article is to share a validated falls risk assessment tool to facilitate identification of fall-related risk factors in the homebound population. A secondary purpose is to share lessons learned by the HHA during the 10 years using the FRA.

  2. Site specific risk assessment of an energy-from-waste thermal treatment facility in Durham Region, Ontario, Canada. Part A: Human health risk assessment.

    Science.gov (United States)

    Ollson, Christopher A; Knopper, Loren D; Whitfield Aslund, Melissa L; Jayasinghe, Ruwan

    2014-01-01

    The regions of Durham and York in Ontario, Canada have partnered to construct an energy-from-waste thermal treatment facility as part of a long term strategy for the management of their municipal solid waste. This paper presents the results of a comprehensive human health risk assessment for this facility. This assessment was based on extensive sampling of baseline environmental conditions (e.g., collection and analysis of air, soil, water, and biota samples) as well as detailed site specific modeling to predict facility-related emissions of 87 identified contaminants of potential concern. Emissions were estimated for both the approved initial operating design capacity of the facility (140,000 tonnes per year) and for the maximum design capacity (400,000 tonnes per year). For the 140,000 tonnes per year scenario, this assessment indicated that facility-related emissions are unlikely to cause adverse health risks to local residents, farmers, or other receptors (e.g., recreational users). For the 400,000 tonnes per year scenarios, slightly elevated risks were noted with respect to inhalation (hydrogen chloride) and infant consumption of breast milk (dioxins and furans), but only during predicted 'upset conditions' (i.e. facility start-up, shutdown, and loss of air pollution control) that represent unusual and/or transient occurrences. However, current provincial regulations require that additional environmental screening would be mandatory prior to expansion of the facility beyond the initial approved capacity (140,000 tonnes per year). Therefore, the potential risks due to upset conditions for the 400,000 tonnes per year scenario should be more closely investigated if future expansion is pursued.

  3. Effectiveness of a web-based health risk assessment with individually-tailored feedback on lifestyle behaviour: study protocol

    Directory of Open Access Journals (Sweden)

    Laan Eva K

    2012-03-01

    Full Text Available Abstract Background Physical inactivity, unhealthy dietary habits, smoking and high alcohol consumption are recognized risk factors for cardiovascular disease and cancer. Web-based health risk assessments with tailored feedback seem promising in promoting a healthy lifestyle. This study evaluates the effectiveness of a web-based health risk assessment with individually-tailored feedback on lifestyle behaviour, conducted in a worksite setting. Methods/Design The web-based health risk assessment starts with a questionnaire covering socio-demographic variables, family and personal medical history, lifestyle behaviour and psychological variables. Prognostic models are used to estimate individual cardiovascular risks. In case of high risk further biometric and laboratory evaluation is advised. All participants receive individually-tailored feedback on their responses to the health risk assessment questionnaire. The study uses a quasi-experimental design with a waiting list control group. Data are collected at baseline (T0 and after six months (T1. Within each company, clusters of employees are allocated to either the intervention or the control group. Primary outcome is lifestyle behaviour, expressed as the sum of five indicators namely physical activity, nutrition, smoking behaviour, alcohol consumption, and symptoms of burnout. Multilevel regression analysis will be used to answer the main research question and to correct for clustering effects. Baseline differences between the intervention and control group in the distribution of characteristics with a potential effect on lifestyle change will be taken into account in further analyses using propensity scores. Discussion This study will increase insight into the effectiveness of health risk assessments with tailored feedback and into conditions that may modify the effectiveness. This information can be used to design effective interventions for lifestyle behaviour change among employees. Trial

  4. Combining spatial distribution with oral bioaccessibility of metals in smelter-impacted soils: implications for human health risk assessment.

    Science.gov (United States)

    Pelfrêne, Aurélie; Détriché, Sébastien; Douay, Francis

    2015-02-01

    Geostatistical analysis and GIS-based spatial mapping have been widely used for risk assessment of environmental pollution. The objectives of this study were to: (1) investigate the spatial variability of pseudototal concentrations of Cd, Pb, and Zn; (2) estimate the degree of contamination on the basis of pollution indexes; and (3) combine geostatistical analysis with oral bioaccessibility to better assess the population's exposure to metals in smelter-impacted soils. Implications for human health risks were assessed by considering soil as a contaminant source, a release mechanism of contaminated soil to the hands, ingestion as an exposure route, and metal bioaccessibility. The bioaccessibility data in the gastric (G) and gastrointestinal (GI) phases were integrated into the standard hazard quotient-based risk assessment method. Using pollution indices showed that the entire area studied was highly polluted in terms of soil metal concentrations. However, the spatial pattern of health risk levels did not coincide with the spatial distribution of the degree of soil contamination. Introducing the bioaccessible fraction of metals from soils into the exposure calculations resulted in a substantial decrease in calculated risk (HI, hazard index) and provided a more realistic estimate of exposure to the three metals. For the highly exposed population, 46% of the soils studied provided an HI-G > 1.0 and 15% provided an HI-GI > 1.0, suggesting probable adverse health effects in children. The present study highlights the importance of conducting studies taking into account metal bioaccessible values in risk assessment.

  5. Environmental health risk assessment of dioxin exposure through foods in a dioxin hot spot-Bien Hoa City, Vietnam.

    Science.gov (United States)

    Tuyet-Hanh, Tran Thi; Vu-Anh, Le; Ngoc-Bich, Nguyen; Tenkate, Thomas

    2010-05-01

    This study used the Australian Environmental Health Risk Assessment Framework to assess the human health risk of dioxin exposure through foods for local residents in two wards of Bien Hoa City, Vietnam. These wards are known hot-spots for dioxin and a range of stakeholders from central government to local levels were involved in this process. Publications on dioxin characteristics and toxicity were reviewed and dioxin concentrations in local soil, mud, foods, milk and blood samples were used as data for this risk assessment. A food frequency survey of 400 randomly selected households in these wards was conducted to provide data for exposure assessment. Results showed that local residents who had consumed locally cultivated foods, especially fresh water fish and bottom-feeding fish, free-ranging chicken, duck, and beef were at a very high risk, with their daily dioxin intake far exceeding the tolerable daily intake recommended by the WHO. Based on the results of this assessment, a multifaceted risk management program was developed and has been recognized as the first public health program ever to have been implemented in Vietnam to reduce the risks of dioxin exposure at dioxin hot-spots.

  6. Environmental Health Risk Assessment of Dioxin Exposure through Foods in a Dioxin Hot Spot—Bien Hoa City, Vietnam

    Directory of Open Access Journals (Sweden)

    Tran Thi Tuyet-Hanh

    2010-05-01

    Full Text Available This study used the Australian Environmental Health Risk Assessment Framework to assess the human health risk of dioxin exposure through foods for local residents in two wards of Bien Hoa City, Vietnam. These wards are known hot-spots for dioxin and a range of stakeholders from central government to local levels were involved in this process. Publications on dioxin characteristics and toxicity were reviewed and dioxin concentrations in local soil, mud, foods, milk and blood samples were used as data for this risk assessment. A food frequency survey of 400 randomly selected households in these wards was conducted to provide data for exposure assessment. Results showed that local residents who had consumed locally cultivated foods, especially fresh water fish and bottom-feeding fish, free-ranging chicken, duck, and beef were at a very high risk, with their daily dioxin intake far exceeding the tolerable daily intake recommended by the WHO. Based on the results of this assessment, a multifaceted risk management program was developed and has been recognized as the first public health program ever to have been implemented in Vietnam to reduce the risks of dioxin exposure at dioxin hot-spots.

  7. [Results of health risk assessment due to exposure to contaminants in drinking water in Russia population (review of literature)].

    Science.gov (United States)

    Unguryanu, T N; Novikov, S M

    2014-01-01

    With the purpose of the analysis of general trends in the development of risk assessment methodology in Russia the results obtained with the her help, as well as existing methodological problems, there was performed a review of 68 published works concerning the assessment of the health risk for population under the exposure to chemicals in drinking water carried out in 42 cities and regions of the country. There was made the grouping of Russian cities on individual carcinogenic risk level and ranking on the values for the population carcinogenic risk. A list of prioritized carcinogens in tap water has been made. By the values of the risk indices to adverse effects of chemicals tap water there are exposed central nervous system, kidneys, liver, skin and mucous membranes, blood, bone, immune system, hormone homeostasis, blood circulation and digestion organs. There are identified methodological problems leading to an underestimation of the actual risk to public health under exposure of chemicals in drinking water: there are no used regional and age differences in exposure factors, virtually there is no assessed health risk for children population; there is ignored age sensitivity to carcinogens, there is rarely estimated exposure for all the real exposing routes of income and there are no carried out risk calculations at the upper limit (90- 95th percentile) of the exposure.

  8. An instrument for broadened risk assessment in antenatal health care including non-medical issues.

    NARCIS (Netherlands)

    A.A. Vos (Amber); M.J. van Veen (Mieke); E. Birnie (Erwin); S. Denktaş (Semiha); E.A.P. Steegers (Eric); G.J. Bonsel (Gouke)

    2015-01-01

    markdownabstractGrowing evidence on the risk contributing role of non-medical factors on pregnancy outcomes urged for a new approach in early antenatal risk selection. The evidence invites to more integration, in particular between the clinical working area and the public health domain. We developed

  9. Assessment of OEP health's risk in nuclear medicine

    Energy Technology Data Exchange (ETDEWEB)

    Santacruz-Gomez, K.; Manzano, C.; Melendrez, R.; Castaneda, B.; Barboza-Flores, M.; Pedroza-Montero, M. [Departamento de Fisica, Universidad de Sonora. A.P. 1626 Hermosillo, Sonora, Mexico and Centro de Investigacion en Materiales Avanzados CIMAV, A.C. Chihuahua, Chihuahua (Mexico); Centro de Diagnostico Integral del Noroeste, Luis Donaldo Colosio 23 83000 Centro Hermosillo, Sonora (Mexico); Departamento de Investigacion en Fisica, Universidad de Sonora. A. P. 5-088 Hermosillo, Sonora (Mexico); Departamento de Fisica, Universidad de Sonora. A.P. 1626 Hermosillo, Sonora (Mexico); Departamento de Investigacion en Fisica, Universidad de Sonora. A. P. 5-088 Hermosillo, Sonora (Mexico)

    2012-10-23

    The use of ionizing radiation has been increased in recent years within medical applications. Nuclear Medicine Department offers both treatment and diagnosis of diseases using radioisotopes to controlled doses. Despite the great benefits to the patient, there is an inherent risk to workers which remains in contact with radiation sources for long periods. These personnel must be monitored to avoid deterministic effects. In this work, we retrospectively evaluated occupationally exposed personnel (OEP) to ionizing radiation in nuclear medicine during the last five years. We assessed both area and personal dosimetry of this department in a known Clinic in Sonora. Our results show an annual equivalent dose average of 4.49 {+-} 0.70 mSv in OEP without showing alarming changes in clinical parameters analyzed. These results allow us to conclude that health of OEP in nuclear medicine of this clinic has not been at risk during the evaluated period. However, we may suggest the use of individual profiles based on specific radiosensitivity markers.

  10. Hygienic assessment of priority risk factors of environment and health condition of the population of Moscow

    Directory of Open Access Journals (Sweden)

    E.E. Andreeva

    2016-09-01

    Full Text Available The article describes the results of work on the dual hygienic assessment of priority risk factors of the environment and the health condition of the population of Moscow. It is shown that in the territory of the metropolis the impact of conditions of negative factors on human health is retained. These trends are confirmed by the excess of the hygienic standards of pollutants in ambient air (up to 6.6 TLVc.e., by the substantial increase (up to 65.8 % of share of the centralized sources of water supply, water quality does not meet the hygienic standards due to the high level of non-standard samples of soil (more than 50 % on a number of sanitary-chemical and microbiological parameters in the territories of certain administrative districts. At the same time there is a tendency to a decrease in non-standard drinking water samples taken from the distribution network of centralized drinking water supply (from 4.36 % to 2.45 %. It was established that the primary morbidity have a number of positive trends to decrease, but exceeds the average indicators for individual classes and nosology, including the classes of "Respiratory diseases", "Diseases of the skin and subcutaneous tissue", "Neoplasms" and etc. by 4.1–68.3 %. Analysis of causality (about 50 significant biologically-based mathematical models were received on the system of "quality of habitat (a risk factor – health status (morbidity, mortality " showed that the impact of negative environmental factors probably shape up to 29.2 ‰ of additional cases and up to 0.056 ‰ of the additional deaths per year. The largest contribution to the formation of the probability of additional cases is made by the excess of morbidity by hygienic standards of air quality and soil, mortality and air quality. Risk factors are phenol, benzo a pyrene, nitrogen dioxide, suspended solids, ammonia, chlorine and its compounds, and sulfur dioxide, etc., coming from the atmospheric air, and cadmium

  11. Assessing patient safety risk before the injury occurs: an introduction to sociotechnical probabilistic risk modelling in health care.

    Science.gov (United States)

    Marx, D A; Slonim, A D

    2003-12-01

    Since 1 July 2001 the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) has required each accredited hospital to conduct at least one proactive risk assessment annually. Failure modes and effects analysis (FMEA) was recommended as one tool for conducting this task. This paper examines the limitations of FMEA and introduces a second tool used by the aviation and nuclear industries to examine low frequency, high impact events in complex systems. The adapted tool, known as sociotechnical probabilistic risk assessment (ST-PRA), provides an alternative for proactively identifying, prioritizing, and mitigating patient safety risk. The uniqueness of ST-PRA is its ability to model combinations of equipment failures, human error, at risk behavioral norms, and recovery opportunities through the use of fault trees. While ST-PRA is a complex, high end risk modelling tool, it provides an opportunity to visualize system risk in a manner that is not possible through FMEA.

  12. [Risk assessment of health disorders and quality of life in employees of modern polyvinyl chloride production].

    Science.gov (United States)

    Meshchakova, N M; D'iakovich, M P; Shaiakhmetov, S F; D'iakovich, O A; Telezhkin, V V

    2014-01-01

    The authors analyse changes in exposure load and associated occupational risk, health state of workers engaged into contemporary polyvinyl chloride production. Consideration covered objective parameters--results of thorough medical examinations -and subjective ones--results of quantitative risk evaluation of general pathologic syndromes and life quality caused by health state. The latter were compared with general working population unexposed to the hazards. Findings are statistically significant increase of functional disorders risk connected with cardiovascular and nervous diseases. Correlation was found between cardiovascular diseases prevalence and exposure chemical load. Statistically significant differences were seen in all life quality components between the workers groups compared.

  13. Developing an Evidence-Based Epilepsy Risk Assessment eHealth Solution: From Concept to Market

    Science.gov (United States)

    Shankar, Rohit; Hanna, Jane; McLean, Brendan; Osland, Alex; Milligan, Cathryn; Ball, Abbie; Jory, Caryn; Walker, Matthew

    2016-01-01

    Introduction Sudden unexpected death in epilepsy (SUDEP) is possibly the most common cause of death as a result of complications from epilepsy. The need to educate and regularly review risk for all patients with epilepsy is paramount, but rarely delivered in actual clinical practice. Evidence suggests that education around SUDEP and modifiable risk variables translate into better self-management of epilepsy. Objective We aimed to develop and implement an eHealth solution to support education and self-management of risks, in epilepsy. Methods We undertook an innovation pathways approach, including problem identification, feasibility assessment, design, implementation, and marketing. People with epilepsy were provided a smartphone-based app (Epilepsy Self-Monitor, EpSMon), which translates the clinical risk assessment tool into an educational and self-monitoring platform, for the self-management of epilepsy. Results Results include the success of the marketing campaign, and in what areas, with an estimated reach of approximately 38 million people. EpSMon has proved a success in academic and clinical circles, attracting awards and nominations for awards. The number of users of EpSMon, after 3 months, turned out to be lower than expected (N=221). A 4-month trial of the app in use in the United Kingdom, and the success of the marketing strategy, point to necessary changes to the model of delivery and marketing, summarized in this paper. These include the marketing message, user cost model, and need for the availability of an Android version. Conclusions EpSMon has proven a success in respect to its reception by academics, clinicians, stakeholder groups, and the patients who use it. There is work needed to promote the model and increase its acceptability/attractiveness, including broadening the marketing message, increasing its availability, and reducing its cost. Future development and promotion of the tool will hopefully inform iterative design of its core features for

  14. A novel land use approach for assessment of human health: The relationship between urban structure types and cardiorespiratory disease risk.

    Science.gov (United States)

    Réquia Júnior, Weeberb João; Roig, Henrique Llacer; Koutrakis, Petros

    2015-12-01

    Extensive evidence shows that in addition to lifestyle factors, environmental aspects are an important risk factor for human health. Numerous approaches have been used to estimate the relationship between environment and health. For example, the urban characteristics, especially the types of land use, are considered a potential proxy indicator to evaluate risk of disease. Although several studies have used land use variables to assess human health, none of them has used the concept of Urban Morphology by Urban Structure Types (USTs) as indicators of land use. The aim of this study was to assess the relationship between USTs and cardiorespiratory disease risks in the Federal District, Brazil. Toward this end, we used a quantile regression model to estimate risk. We used 21 types of UST. Income and population density were used as covariates in our sensitivity analysis. Our analysis showed an association between cardiorespiratory diseases risk and 10 UST variables (1 related to rural area, 6 related to residential area, 1 recreational area, 1 public area and 1 commercial area). Our findings suggest that the conventional land use method may be missing important information about the effect of land use on human health. The use of USTs can be an approach to complement the conventional method. This should be of interest to policy makers in order to enhance public health policies and to create future strategies in terms of urban planning, land use and environmental health.

  15. Microbiological Quantitative Risk Assessment

    Science.gov (United States)

    Dominguez, Silvia; Schaffner, Donald W.

    The meat and poultry industry faces ongoing challenges due to the natural association of pathogens of concern (e.g., Salmonella, Campylobacter jejuni, Escherichia coli O157:H7) with a variety of domesticated food animals. In addition, pathogens such as Listeria monocytogenes pose a significant cross-contamination risk during further meat and poultry processing, distribution, and storage. Furthermore, the meat and poultry industries are constantly changing with the addition of new products, use of new raw materials, and targeting of new consumer populations, each of which may give rise to potential new risks. National and international regulations are increasingly using a “risk-based” approach to food safety (where the regulatory focus is driven by the magnitude of the risk), so risk assessment is becoming a valuable tool to systematically organize and evaluate the potential public health risk posed by food processing operations.

  16. Preliminary Assessment of Health Risks of Potentially Toxic Elements in Settled Dust over Beijing Urban Area

    Directory of Open Access Journals (Sweden)

    Dejun Wan

    2016-05-01

    Full Text Available To examine levels, health risks, sources, and spatial distributions of potentially toxic elements in settled dust over Beijing urban area, 62 samples were collected mostly from residential building outdoor surfaces, and their <63 μm fractions were measured for 12 potentially toxic elements. The results show that V, Cr, Mn, Co, Ni, and Ba in dust are from predominantly natural sources, whereas Cu, Zn, As, Cd, Sb, and Pb mostly originate from anthropogenic sources. Exposure to these elements in dust has significant non-cancer risks to children but insignificant to adults. Cancer risks of Cr, Co, Ni, As, and Cd via inhalation and dermal contact are below the threshold of 10−6–10−4 but As via dust ingestion shows a tolerable risk. The non-cancer risks to children are contributed mainly (75% by As, Pb, and Sb, and dominantly (92% via dust ingestion, with relatively higher risks mainly occurring in the eastern and northeastern Beijing urban areas. Although Cd, Zn, and Cu in dust are heavily affected by anthropogenic sources, their health risks are insignificant. Source appointments suggest that coal burning emissions, the dominant source of As, are likely the largest contributors to the health risk, and traffic-related and industrial emissions are also important because they contribute most of the Pb and Sb in dust.

  17. Health risk assessment along the wastewater and faecal sludge management and reuse chain of Kampala, Uganda: a visualization.

    Science.gov (United States)

    Fuhrimann, Samuel; Winkler, Mirko S; Schneeberger, Pierre H H; Niwagaba, Charles B; Buwule, Joseph; Babu, Mohammed; Medlicott, Kate; Utzinger, Jürg; Cissé, Guéladio

    2014-11-01

    Reuse of wastewater in agriculture is a common feature in the developing world. While this strategy might contribute to the livelihood of farming communities, there are health risks associated with the management and reuse of wastewater and faecal sludge. We visualise here an assessment of health risks along the major wastewater channel in Kampala, Uganda. The visualization brings to bear the context of wastewater reuse activities in the Nakivubo wetlands and emphasises interconnections to disease transmission pathways. The contextual features are complemented with findings from environmental sampling and a cross-sectional epidemiological survey in selected exposure groups. Our documentation can serve as a case study for a step-by-step implementation of risk assessment and management as described in the World Health Organization's 2006 guidelines for the safe use of wastewater, greywater and excreta in light of the forthcoming sanitation safety planning approach.

  18. Health risk assessment along the wastewater and faecal sludge management and reuse chain of Kampala, Uganda: a visualization

    Directory of Open Access Journals (Sweden)

    Samuel Fuhrimann

    2014-11-01

    Full Text Available Reuse of wastewater in agriculture is a common feature in the developing world. While this strategy might con- tribute to the livelihood of farming communities, there are health risks associated with the management and reuse of wastewater and faecal sludge. We visualise here an assessment of health risks along the major wastewater channel in Kampala, Uganda. The visualization brings to bear the context of wastewater reuse activities in the Nakivubo wetlands and emphasises interconnections to disease transmission pathways. The contextual features are complemented with findings from environmental sampling and a cross-sectional epidemiological survey in selected exposure groups. Our documentation can serve as a case study for a step-by-step implementation of risk assessment and management as described in the World Health Organization’s 2006 guidelines for the safe use of wastewater, greywater and excreta in light of the forthcoming san- itation safety planning approach.

  19. Failures in risk assessment and risk management for cosmetic preservatives in Europe and the impact on public health

    DEFF Research Database (Denmark)

    Schwensen, Jakob F; White, Ian R; Thyssen, Jacob P

    2015-01-01

    BACKGROUND: In view of the current and unprecedented increase in contact allergy to methylisothiazolinone (MI), we characterized and evaluated two recent epidemics of contact allergy to preservatives used in cosmetic products to address failures in risk assessment and risk management. OBJECTIVE...... the proportion of patients with current clinical disease attributable to methyldibromo glutaronitrile contact allergy decreased significantly following the ban on its use in cosmetic products (p ....001). CONCLUSIONS: The introduction of new preservatives in Europe with inadequate pre-market risk assessment has rapidly increased the overall burden of cutaneous disease caused by preservatives. We suggest that the cosmetic industry has a responsibility to react faster and replace troublesome preservatives when...

  20. Assessing perceived health risks of climate change : Canadian public opinion 2008

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-03-15

    This paper discussed a survey conducted to evaluate the awareness, knowledge, attitudes, and behaviours of Canadians in relation to climatic change. A total of 1600 telephone surveys were conducted with a broad range of age groups. The study showed that climate change is considered by many Canadians to pose a significant threat at both local and global levels. Evidence of climate change has been noted in many communities. However, relatively few Canadians understand how climate change may impact human health. While many Canadians associated climatic change with air pollution hazards and ozone depletion, most Canadians were not aware of the potential negative health impacts related to changes in disease vectors, extreme weather events, and coastal flooding. The strongest awareness and concern about health impacts were expressed by Canadians concerned about global warming. Individuals with chronic health conditions were more likely to be attuned to the potential health impacts of climatic change. Seniors viewed climate change as a longer term problem. Only 10 per cent of Canadians viewed global warming as a major health risk. Sixty-nine per cent of Canadians believed that global warming was happening, while 63 per cent attributed climate change to human activity. Nearly half of all respondents believed that an extreme weather disaster would affect their community during the course of their lifetime. The report suggested that marketing or communications campaigns should build public awareness of the health risks associated with direct or proximal environmental risks. Information about health risks should be specific, and communications should be tailored to age cohorts. Television and print media should be used to build awareness of the health risks of climate change. Provincial concerns related to climatic change were also outlined. tabs., figs.

  1. Assessing Aggression Risks in Patients of the Ambulatory Mental Health Crisis Team

    NARCIS (Netherlands)

    Penterman, E.J.M.; Nijman, H.L.I.

    2011-01-01

    During outreaching crisis visits, crisis team members run the risk of being confronted with aggressive behavior from their patients. To prevent dangerous situations, a method to assess risks in advance, on the basis of information received before the visit to the patient in crisis, could prove usefu

  2. Screening Assessment of Potential Human-Health Risk from Future Natural-Gas Drilling Near Project Rulison in Western Colorado

    Energy Technology Data Exchange (ETDEWEB)

    Daniels Jeffrey I.,Chapman Jenny B.

    2012-01-01

    The Project Rulison underground nuclear test was conducted in 1969 at a depth of 8,400 ft in the Williams Fork Formation of the Piceance Basin, west-central Colorado (Figure 1). The U.S. Department of Energy Office of Legacy Management (LM) is the steward of the site. Their management is guided by data collected from past site investigations and current monitoring, and by the results of calculations of expected behavior of contaminants remaining in the deep subsurface. The purpose of this screening risk assessment is to evaluate possible health risks from current and future exposure to Rulison contaminants so the information can be factored into LM's stewardship decisions. For example, these risk assessment results can inform decisions regarding institutional controls at the site and appropriate monitoring of nearby natural-gas extraction activities. Specifically, the screening risk analysis can provide guidance for setting appropriate action levels for contaminant monitoring to ensure protection of human health.

  3. [Attaching importance to study on acute health risk assessment and adaptation of air pollution and climate change].

    Science.gov (United States)

    Shi, X M

    2017-03-10

    Air pollution and climate change have become key environmental and public health problems around the world, which poses serious threat to human health. How to assess and mitigate the health risks and increase the adaptation of the public have become an urgent topic of research in this area. The six papers in this issue will provide important and rich information on design, analysis method, indicator selection and setting about acute health risk assessment and adaptation study of air pollution and climate change in China, reflecting the advanced conceptions of multi-center and area-specific study and multi-pollutant causing acute effect study. However, the number and type of the cities included in these studies were still limited. In future, researchers should further expand detailed multi-center and multi-area study coverage, conduct area specific predicting and early warning study and strengthen adaptation study.

  4. Assessment of cancer and noncancer health risks from exposure to PAHs in street dust in the Tamale Metropolis, Ghana.

    Science.gov (United States)

    Obiri, Samuel; Cobbina, Samuel J; Armah, Frederick A; Luginaah, Isaac

    2013-01-01

    This study is part of a broader initiative to characterize, quantify and assess the human health risk associated with exposure to polycyclic aromatic hydrocarbons (PAHs) in street dust along the Trans-ECOWAS highway in West Africa. In the first part, PAHs were characterized and quantified in low- and high-traffic zones. In this study, cancer and noncancer human health risks from exposure to (PAHs) in street dust in the Tamale metropolis, Ghana were assessed in accordance with the USEPA risk assessment guidelines. The results of the study as obtained from inhalation of benzo [a] anthracene (BaA), benzo [a] pyrene (BaP), benzo [k] fluoranthene (BkF) and chrysene via central tendency exposure parameters (CTE) by trespassers (street hawkers including children and adults) in street dust within low traffic zones in the Tamale metropolis are 1.6E-02, 4.7E-02, 1.8E-03, and 1.6E-04 respectively. For reasonable maximum exposure parameters (RME), risk values of 1.2E-01, 3.5E-01, 1.3E-02 and 1.2E-03 respectively were obtained for benzo [a] anthracene, benzo [a] pyrene, benzo [k] fluoranthene and chrysene. Hazard index for acenaphthene, anthracene, fluoranthene, fluorine, naphthalene and pyrene in the CTE and RME scenarios were 2.2, 3.E-01, 2.6, 2.6, 100, 38 and 12, 1.7,15, 14, 550, 210 respectively. Generally, the cancer health risk associated with inhalation of benzo [a] anthracene, benzo [a] pyrene, benzo [k] fluoranthene and chrysene revealed that resident adults and children in the Tamale metropolis are at risk from exposure to these chemicals. The results of this preliminary assessment that quantified PAH related health risks along this part of the Trans-ECOWAS highway revealed that, there is the need for regulatory agencies to put in comprehensive measures to mitigate the risks posed to these categories of human receptors.

  5. Sensitivity of key factors and uncertainties in health risk assessment of benzene pollutant

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Predicting long-term potential human health risks from contaminants in the multimedia environment requires the use of models.However, there is uncertainty associated with these predictions of many parameters which can be represented by ranges or probability distributions rather than single value. Based on a case study with information from an actual site contaminated with benzene, this study describes the application of MMSOILS model to predict health risk and distributions of those predictions generated using Monte Carlo techniques. A sensitivity analysis was performed to evaluate which of the random variables are most important in producing the predicted distributions of health risks. The sensitivity analysis shows that the predicted distributions can be accurately reproduced using a small subset of the random variables. The practical implication of this analysis is the ability to distinguish between important versus unimportant random variables in terms of their sensitivity to selected endpoints. This directly translates into a reduction in data collection and modeling effort. It was demonstrated that how correlation coefficient could be used to evaluate contributions to overall uncertainty from each parameter. The integrated uncertainty analysis shows that although drinking groundwater risk is similar with inhalation air risk, uncertainties of total risk come dominantly from drinking groundwater route. Most percent of the variance of total risk comes from four random variables.

  6. Health risk assessment of exposures to a high molecular weight plasticizer present in automobile interiors.

    Science.gov (United States)

    Perez, Angela L; Liong, Monty; Plotkin, Kevin; Rickabaugh, Keith P; Paustenbach, Dennis J

    2017-01-01

    This study provides an exposure and risk assessment of diundecyl phthalate (DUP), a high molecular weight phthalate plasticizer present in automobile interiors. Total daily intake of DUP was calculated from DUP measured in wipe samples from vehicle seats from six automobiles. Four of the vehicles exhibited atypical visible surface residue on the seats. Two vehicles with no visible surface residue were sampled as a comparison. DUP was the predominant organic compound identified in each of the wipes from all seats. A risk assessment of DUP via oral, dermal, and inhalation routes resulting from contact with automobile seats was conducted. The mean, standard deviation, and maximum DUP concentrations on the seats with visible surface residue were 6983 ± 7823 μg/100 cm(2) and 38300 μg/100 cm(2), respectively. The mean and 95th percentile of the mean for daily cumulative dose of DUP for all exposure routes for the seats with no visible surface residue ranged from 7 × 10(-4) to 4 × 10(-3) mg/kg-day and from 8 × 10(-4) to 5 × 10(-3) mg/kg-day, respectively. For seats with visible surface residue, cumulative doses ranged from 2 × 10(-3) to 2 × 10(-2) mg/kg-day and from 4 × 10(-3) to 2 × 10(-2) mg/kg-day, respectively. The estimated daily intake (contact or absorbed dose) of DUP from automobile seats were far lower than the NOAELs reported in and derived from animal studies, and are well below the reported Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Derived No Effect Levels (DNELs) for the general population. Based on this analysis, using virtually any benchmark for evaluating safety, exposure to DUP via automobile seat covers did not pose a measureable increased health-risk in any population under any reasonably plausible exposure scenario.

  7. Factsheets for the (eco)toxicological risk assessment strategy of the National Institute for Public Health and the Environment (RIVM), Part II

    NARCIS (Netherlands)

    Luttik R; Pelgrom SMGJ; CSR

    2002-01-01

    Five factsheets describing risk assessment methods used at the Centre of Substances and Risk assessment (CSR) of the National Institute for Public Health and the Environment (RIVM) are presented here with the main aim of promoting greater transparency in the risk assessment methods used at the Insti

  8. A dynamic process of health risk assessment for business continuity management during the World Exposition Shanghai, China, 2010.

    Science.gov (United States)

    Sun, Xiaodong; Keim, Mark; Dong, Chen; Mahany, Mollie; Guo, Xiang

    2014-01-01

    Reports of health issues related to mass gatherings around the world have indicated a potential for public health and medical emergencies to occur on a scale that could place a significant impact on business continuity for national and international organisations. This paper describes a risk assessment process for business continuity management that was performed as part of the planning efforts related to the World Expo 2010 Shanghai China (Expo), the world's largest mass gathering to date. Altogether, 73 million visitors attended the Expo, generating over US$2bn of revenue. During 2008 to 2010, the Shanghai Municipal Center for Disease Control and Prevention performed a dynamic series of four disaster risk assessments before and during the Expo. The purpose of this assessment process was to identify, analyse and evaluate risks for public health security during different stages of the Expo. This paper describes an overview of the novel approach for this multiple and dynamic process of assessment of health security risk for ensuring business continuity.

  9. Human health risk assessment in relation to environmental pollution of two artificial freshwater lakes in The Netherlands.

    OpenAIRE

    Albering, H J; Rila, J P; Moonen, E J; Hoogewerff, J A; Kleinjans, J.C.

    1999-01-01

    A human health risk assessment has been performed in relation to recreational activities on two artificial freshwater lakes along the river Meuse in The Netherlands. Although the discharges of contaminants into the river Meuse have been reduced in the last decades, which is reflected in decreasing concentrations of pollutants in surface water and suspended matter, the levels in sediments are more persistent. Sediments of the two freshwater lakes appear highly polluted and may pose a health ri...

  10. Heavy metals contamination and human health risk assessment around Obuasi gold mine in Ghana.

    Science.gov (United States)

    Bempah, Crentsil Kofi; Ewusi, Anthony

    2016-05-01

    Gold mining has increased the prevalence and occurrence of heavy metals contamination at the Earth's surface and is causing major concern due to the potential risk involved. This study investigated the impact of gold mine on heavy metals (As, Cd, Cr, Cu, Pb, Hg, Ni, Fe, Mn, and Zn) pollution and evaluated the potential health risks to local residents via consumption of polluted groundwater, agricultural soils, and vegetable crops grown at three community farms surrounding the mine at Obuasi municipality of Ghana. The results showed levels of As, Cd, Cr, Hg, Fe, and Mn higher than the allowable drinking water standards. The vegetable samples analyzed showed high accumulation of As and Ni above the normal value. Bioaccumulation factors of heavy metals were significantly higher for vegetables grown in the Sanso soils. Estimated average daily intake and hazard quotient for As in drinking water as well as As, Pb, and Hg in vegetable samples exceeded permissible limit. Unacceptable non-cancer health risk levels were found in vegetable samples analyzed for As, Pb, and Hg. An unacceptable cancer risk was found via drinking of groundwater, in consumption of vegetables, and in soil. The hazard index for vegetables was higher than 1, indicating very high health risk to heavy metals contamination through consumption of vegetables grown around the sampling sites. The results recommend the need for regular monitoring of groundwater and food crops to protect consumers' health.

  11. Assessing risk to human health from tropical leafy vegetables grown on contaminated urban soils

    Energy Technology Data Exchange (ETDEWEB)

    Nabulo, G.; Young, S.D.; Black, C.R., E-mail: colin.black@nottingham.ac.uk [School of Biosciences, University of Nottingham, Nottingham, NG7 2RD (United Kingdom)

    2010-10-15

    Fifteen tropical leafy vegetable types were sampled from farmers' gardens situated on nine contaminated sites used to grow vegetables for commercial or subsistence consumption in and around Kampala City, Uganda. Trace metal concentrations in soils were highly variable and originated from irrigation with wastewater, effluent discharge from industry and dumping of solid waste. Metal concentrations in the edible shoots of vegetables also differed greatly between, and within, sites. Gynandropsis gynandra consistently accumulated the highest Cd, Pb and Cu concentrations, while Amaranthus dubius accumulated the highest Zn concentration. Cadmium uptake from soils with contrasting sources and severity of contamination was consistently lowest in Cucurbita maxima and Vigna unguiculata, suggesting these species were most able to restrict Cd uptake from contaminated soil. Concentrations of Pb and Cr were consistently greater in unwashed, than in washed, vegetables, in marked contrast to Cd, Ni and Zn. The risk to human health, expressed as a 'hazard quotient' (HQ{sub M}), was generally greatest for Cd, followed successively by Pb, Zn, Ni and Cu. Nevertheless, it was apparent that urban cultivation of leafy vegetables could be safely pursued on most sites, subject to site-specific assessment of soil metal burden, judicious choice of vegetable types and adoption of washing in clean water prior to cooking.

  12. Human health impact of Salmonella contamination in imported soybean products: A semiquantitative risk assessment

    DEFF Research Database (Denmark)

    Hald, Tine; Wingstrand, Anne; Brondsted, T.

    2006-01-01

    The objectives of our study were to estimate the number of reported cases of human salmonellosis in Denmark that can be attributed to the occurrence of Salmonella in soy-based animal feed and to assess whether certain serotypes can be considered of less importance to human health. The assessment ...

  13. Microbial Risk Assessment

    Science.gov (United States)

    Ott, C. M.; Mena, K. D.; Nickerson, C.A.; Pierson, D. L.

    2009-01-01

    Historically, microbiological spaceflight requirements have been established in a subjective manner based upon expert opinion of both environmental and clinical monitoring results and the incidence of disease. The limited amount of data, especially from long-duration missions, has created very conservative requirements based primarily on the concentration of microorganisms. Periodic reevaluations of new data from later missions have allowed some relaxation of these stringent requirements. However, the requirements remain very conservative and subjective in nature, and the risk of crew illness due to infectious microorganisms is not well defined. The use of modeling techniques for microbial risk has been applied in the food and potable water industries and has exceptional potential for spaceflight applications. From a productivity standpoint, this type of modeling can (1) decrease unnecessary costs and resource usage and (2) prevent inadequate or inappropriate data for health assessment. In addition, a quantitative model has several advantages for risk management and communication. By identifying the variable components of the model and the knowledge associated with each component, this type of modeling can: (1) Systematically identify and close knowledge gaps, (2) Systematically identify acceptable and unacceptable risks, (3) Improve communication with stakeholders as to the reasons for resource use, and (4) Facilitate external scientific approval of the NASA requirements. The modeling of microbial risk involves the evaluation of several key factors including hazard identification, crew exposure assessment, dose-response assessment, and risk characterization. Many of these factors are similar to conditions found on Earth; however, the spaceflight environment is very specialized as the inhabitants live in a small, semi-closed environment that is often dependent on regenerative life support systems. To further complicate modeling efforts, microbial dose

  14. Chemical speciation of trace metals emitted from Indonesian peat fires for health risk assessment

    Science.gov (United States)

    Betha, Raghu; Pradani, Maharani; Lestari, Puji; Joshi, Umid Man; Reid, Jeffrey S.; Balasubramanian, Rajasekhar

    2013-03-01

    Regional smoke-induced haze in Southeast Asia, caused by uncontrolled forest and peat fires in Indonesia, is of major environmental and health concern. In this study, we estimated carcinogenic and non-carcinogenic health risk due to exposure to fine particles (PM2.5) as emitted from peat fires at Kalimantan, Indonesia. For the health risk analysis, chemical speciation (exchangeable, reducible, oxidizable, and residual fractions) of 12 trace metals (Al, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Ti, V and Zn) in PM2.5 was studied. Results indicate that Al, Fe and Ti together accounted for a major fraction of total metal concentrations (~ 83%) in PM2.5 emissions in the immediate vicinity of peat fires. Chemical speciation reveals that a major proportion of most of the metals, with the exception of Cr, Mn, Fe, Ni and Cd, was present in the residual fraction. The exchangeable fraction of metals, which represents their bioavailability, could play a major role in inducing human health effects of PM2.5. This fraction contained carcinogenic metals such as Cd (39.2 ng m- 3) and Ni (249.3 ng m- 3) that exceeded their WHO guideline values by several factors. Health risk estimates suggest that exposure to PM2.5 emissions in the vicinity of peat fires poses serious health threats.

  15. Health risks of electromagnetic fields. Part I: Evaluation and assessment of electric and magnetic fields.

    Science.gov (United States)

    Habash, Riadh W Y; Brodsky, Lynn M; Leiss, William; Krewski, Daniel; Repacholi, Michael

    2003-01-01

    Exposure to electric and magnetic fields (EMF) emanating from the generation, distribution, and utilization of electricity is widespread. The major debate in recent years has focused on the possibility that exposure to EMF may result in adverse health consequences, including the development of cancer. This article provides a review and evaluation of potential health risks associated with residential and occupational exposure to EMF. In addition to reviewing data from laboratory, epidemiology, and clinical studies, we examine exposure data from field measurement surveys and exposure guidelines that have been established for EMF. Currently, the evidence in support of an association between EMF and childhood cancer is limited, although this issue warrants further investigation. Evidence of an association between EMF exposure and adult cancers, derived largely from occupational settings, is inconsistent, precluding clear conclusions. There is little evidence of an association between EMF and noncancer health effects. Epidemiological studies of EMF and population health are limited by exposure measurement error and the lack of a clear dose/response relationship in studies suggesting possible health risks. Further research is needed to clarify the ambiguous findings from present studies and to determine if EMF exposure poses a health risk.

  16. Risk posed by the Ebola epidemic to the Pacific islands: findings of a recent World Health Organization assessment

    Directory of Open Access Journals (Sweden)

    Adam T Craig

    2015-04-01

    Full Text Available Objective: To assess the public health risk posed by the ongoing Ebola virus disease (EVD epidemic in West Africa to Pacific island countries and areas and to highlight priority risk management actions for preparedness and response. Method: The likelihood of EVD importation and the magnitude of public health impact in Pacific island countries and areas were assessed to determine overall risk. Literature about the hazard, epidemiology, exposure and contextual factors associated with EVD was collected and reviewed. Epidemiological information from the current EVD outbreak was assessed. Results: As of 11 March 2015, there have been more than 24 200 reported cases of EVD and at least 9976 deaths in six West African countries. Three EVD cases have been infected outside of the West African region, and all have epidemiological links to the outbreak in West Africa. Pacific island countries’ and areas’ relative geographic isolation and lack of travel or trade links between countries with transmission means that EVD importation is very unlikely. However, should a case be imported, the health and non-health consequences would be major. The capacity of Pacific island countries and areas to respond adequately varies greatly between (and within states but in general is limited. Discussion: This risk assessment highlights the needs to enhance preparedness for EVD in the Pacific by strengthening the capacities outlined in the World Health Organization Framework for Action on Ebola. Priority areas include the ability to detect and respond to suspected EVD cases quickly, isolation and management of cases in appropriately resourced facilities and the prevention of further cases through infection prevention and control. These efforts for Ebola should enhance all-hazards public health preparedness in line with the International Health Regulations (2005.

  17. Mercury contamination in fish from gold mining areas in Indonesia and human health risk assessment.

    Science.gov (United States)

    Castilhos, Zuleica C; Rodrigues-Filho, Saulo; Rodrigues, Ana Paula C; Villas-Bôas, Roberto C; Siegel, Shefa; Veiga, Marcello M; Beinhoff, Christian

    2006-09-01

    This study investigates the effects on fish and assesses human health hazards from mercury released in two gold mining areas in Indonesia: Tatelu (North Sulawesi Province) and Galangan (Katingan District, Central Kalimatan Province). In Tatelu, 154 fish specimens of 10 freshwater species were collected, as well as five marine species from the fish market. The mean concentration of total mercury in muscles of freshwater fish from this area was 0.58+/-0.44 microg/g, with more than 45% of fish having Hg levels above the WHO guideline for human consumption of 0.5 microg/g. In Galangan, where 263 fish specimens of 25 species were collected, the total mercury in muscles averaged 0.25+/-0.69 microg/g. Excluding data from flooded open pits in sub-area P4, mean Hg levels in fish from Galangan were 2 to 4 times lower than 0.5 microg/g, while fewer than 10% of fish from Galangan exceeded WHO guidelines. The Hazard Quotient (HQ) was applied to both areas to determine the threat of MeHg exposure for communities in both areas. The HQ is a risk assessment indicator which defines the ratio of exposure level to a single substance in relation to a reference dose. Samples from Tatelu (excluding marine species) had an HQ above one, while those from Galangan resulted in values of 2.4 for the whole area and 9.9 for sub-area P4, pointing to potentially harmful fish consumption for the local population. By using the single-compartment model to estimate mercury levels in blood and hair from daily intake dose, sub-area P4 showed the highest levels, higher than the upper limit guideline for pregnant women, but still lower than threshold levels associated with observed clinical effects.

  18. Health disorders related to learning the welding trade: assessment of approaches to risk communication

    Directory of Open Access Journals (Sweden)

    Clarice Alves Bonow

    2014-01-01

    Full Text Available OBJECTIVE: to assess the identification of health disorders as self-reported by apprentices of welding and to analyze the strength of the relationship between age and time of experience with self-reported health disorders before and after a socio-environmental nursing intervention. METHOD: this quasi-experimental, non-randomized, before-and-after study was conducted with 86 welding apprentices from a private entity. RESULTS: the results show a significant difference for the pre- and post-test means and an increase in the post-test mean score for the cardiovascular, respiratory and cutaneous systems. There was also a negative correlation between the apprentices' ages and the identification of health disorders. CONCLUSION: the socio-environmental nursing intervention enabled obtaining information on health disorders related to welding. In turn, such information enabled the apprentices to assess information and self-report health disorders.

  19. A comparison of risk modeling tools and a case study for human health risk assessment of volatile organic compounds in contaminated groundwater.

    Science.gov (United States)

    Han, Lu; Qian, Linbo; Yan, Jingchun; Liu, Rongqin; Du, Yihua; Chen, Mengfang

    2016-01-01

    In order to promote the risk-based strategy in the investigation, assessment, and remediation of Chinese brownfield sites, the Health and Environmental Risk Assessment (HERA) software was developed. It is vital to validate the HERA model and compare the inter-model differences of HERA model against other available risk assessment tools. This paper discusses the similarities and differences between the Risk-Based Corrective Action (RBCA) Tool Kit and the HERA model by evaluating the health risk of organic contaminated groundwater sources for a chemical works in China for the first time. Consequently, the HERA and RBCA models yielded the identical results for Site-Specific Assessment Criteria (SSAC) under the commercial redevelopment. However, the HERA estimated more conservative and stringent SSACs under the residential scenario based on the different exposure calculations. The inhalation of indoor vapors was the most predominated exposure pathway for all the volatile organic compounds (VOCs) determined using the RBCA and HERA models. According to the HERA model, inhalation of chloroform may cause the highest unacceptable carcinogenic risk at 2.31 × 10(-3) under the residential scenario. Therefore, it is recommended that a risk-based remedial strategy be developed to ensure the safe and sustainable redevelopment of the site.

  20. Consideration on the health risk reduction related to attainment of the new particulate matter standards in Poland: A top-down policy risk assessment approach.

    Science.gov (United States)

    Kobza, Joanna; Pastuszka, Józef S; Gulis, Gabriel

    2016-01-01

    Policies can influence health of a population in various ways. Numerous epidemiological studies supported by toxicological investigations demonstrate a positive association between ambient concentrations of airborne particulate matter and increased adverse cardio-respiratory events, including morbidity and mortality. The aim of this paper was to present the concept of the top-down health policy risk assessment approach model developed to estimate the expected health risk reduction associated with policy aiming at attaining the new particulate matter ≤ 10 μm in diameter (PM10) standards in Poland. The top-down approach guides the analysis of causal chains from the policy to health outcomes. In this case study we tried to estimate the predicted health effects of the policy change over the past 20 years. Since Polish annual standard for PM10 changed from 50 μg/m³ in 1990 to 40 μg/m³ in 2010, we calculated the relative risk associated with decreasing PM10 in diameter to 10 μg/m3 in the annual level of PM10 for 6 adverse health effects. The relative risk slightly decreased for almost all adverse health effects, which means that the relative decrease in the incidence of health effects from the baseline incidence should range from about 0.5-0.6% for heart disease admissions to > 1% for respiratory admissions. The obtained results indicate that implementation of the new ambient air standards could influence improvement of the health status of Polish population. A top-down policy health risk assessment model can be one of the main tools in this process, providing harmonized guidance how to seek evidence-based information, which could serve policy-makers.

  1. Methylmercury risk assessment issues

    Energy Technology Data Exchange (ETDEWEB)

    Lipfert, F.W. [Brookhaven National Lab., Upton, NY (United States); Saroff, L. [USDOE, Washington, DC (United States)

    1996-07-01

    This paper reviews the general background of health risks associated with mercury (Hg), primarily methylmercury (MeHg), with a view towards application to advanced technologies that could reduce any contributions from coal combustion. The need for accurate assessment of such risks is discussed, since Hg is now widely dispersed in the environment and cannot easily be eliminated. The primary pathway of MeHg intake is through eating contaminated fish. The issues of concern include identification of critical health outcomes (various neurological indices) and their confounding factors, accurate assessment of MeHg intake rates, and appropriate use of dose-response functions. Ultimately, such information will be used to evaluate alternative coal combustion systems.

  2. [Health risk assessment of heavy metals in typical township water sources in DongjianG River basin].

    Science.gov (United States)

    Wang, Ruo-Shi; Xu, Qiu-Jin; Zhang, Xian; Wei, Qun-Shan; Yan, Chang-Zhou

    2012-09-01

    In order to clarify the distribution characteristics and risk levels of heavy metals in typical drinking water sources of towns in Dongjiang River Basin, several regular water quality indexes as well as concentrations of Fe, Cu, Mn, Zn, As, Cr, Hg, Pb and Cd were analyzed in the 45 random water samples of 9 towns in the study area. The risk assessment was conducted according to different drinking water types using the environmental health risk assessment model recommended by U. S. EPA. The results indicated that the metal carcinogenic risk is relatively high in this area. The highest carcinogenic risk was from Cr in reservoir water, with the risk for adult people reaching 1.14 x 10(-4) x(-1) and the risk of children reaching 2.14 x 10(-4) x a(-1). Total carcinogenic risk of reservoir, river and underground water exceeded the accepted level of 5.0 x 10(5) x a(-1) as suggested by ICRP while all the non-carcinogenic risk levels were within the acceptable range. The primary control sequence of metal pollution in this area was Cr > As > Pb > Fe > Zn; the risk value of different drinking water sources descended in this order: reservoir > river > underground water > mountain spring.

  3. Assessment of health risk due to PM 10 using fuzzy linear membership kriging with particle swarm optimization

    Energy Technology Data Exchange (ETDEWEB)

    Singh, Jeetendra B.; Reddy, Vijay S.; Jana, Soumya [Indian Institute of Technology, Hyderabad (India). Dept. of Electrical Engineering; De, Swades [Indian Institute of Technology, Delhi (India). Dept. of Electrical Engineering

    2013-07-01

    Air quality is an important determinant of individual as well as broader well-being. Major pollutants include gasses as well as assorted suspended particulate matter (PM). In this paper, we focus on PM10, which are a collection of particles with median aerodynamic diameter less than 10 {mu}m that remains suspended in the air for long periods. PM10, usually consist of smoke, dirt and dust particles, as well as spores and pollen, could easily be inhaled deep into lung. As a result, high outdoor PM10 concentration poses significant health hazard, and accurate modeling and prediction of health risk due to PM10 assume importance in pollution and public health management. In this backdrop, we propose an improved health risk assessment technique, and demonstrate its efficacy using widely used California PM10 database. At the heart of the proposed method lies indicator kriging, a well-known risk estimation technique. However, improved assessment of subjective health risk is achieved by posing the problem in a fuzzy setting, and optimizing the associated membership functions. In particular, we employ particle swarm optimization (PSO) algorithm, which has been motivated by natural behavior of organisms such as fish-schooling and bird flocking, and proven effective in various optimization contexts. We apply the fuzzy PSO membership grade kriging technique to predict the PM10 spatial distribution over the entire California state. (orig.)

  4. Dietary patterns in transition can inform health risk, but detailed assessments are needed to guide recommendations

    Science.gov (United States)

    Most research on diet and health has historically focused on single nutrients or foods and their effect on disease outcomes. In recent years, this focus has shifted to include the total dietary pattern as a risk factor in epidemiologic studies. This change has occurred for several reasons. First, as...

  5. A simplified method for quantitative assessment of the relative health and safety risk of environmental management activities

    Energy Technology Data Exchange (ETDEWEB)

    Eide, S.A.; Smith, T.H.; Peatross, R.G.; Stepan, I.E.

    1996-09-01

    This report presents a simplified method to assess the health and safety risk of Environmental Management activities of the US Department of Energy (DOE). The method applies to all types of Environmental Management activities including waste management, environmental restoration, and decontamination and decommissioning. The method is particularly useful for planning or tradeoff studies involving multiple conceptual options because it combines rapid evaluation with a quantitative approach. The method is also potentially applicable to risk assessments of activities other than DOE Environmental Management activities if rapid quantitative results are desired.

  6. Human health risk assessment: heavy metals contamination of vegetables in Bahawalpur, Pakistan

    Directory of Open Access Journals (Sweden)

    Hafiza Hira Iqbal

    2016-01-01

    Full Text Available Dietary exposure of toxic metals is of vital concern for human health through vegetable consumption, especially in developing countries. Aim of the current study was to determine the health risk associated with vegetables contamination by heavy metals being irrigated with sewage and turbine water. The water sources, soils and vegetables were analyzed for selected metals viz: Pb, Cd, Cr and Ni. Heavy metals in water samples are found to be lower than the international norms except Cd in sewage water. By contrast, concentration of heavy metals in soil and vegetables irrigated with turbine water were lower than the safe limits. In case of vegetables irrigated with sewage water, Cd was higher in soil while Pb, Cd and Cr were higher in most of the vegetables. Furthermore, health risk index values for Cd, Pb and Ni were exceeded the permissible limits (European Union, 2002. Bio-concentration factor (BCF was found to be maximum (16.4 mg/kg in Coriandrum sativum, cultivated with sewage water. Raphanus caudatus, Coriandrum sativum, Daucus carota, Allium sativum and Solanum tuberosum showed Health Risk Index of Cd > 1 in adults and children. Allium sativum also showed HRI of Pb > 1 in children. We conclude that the quality of vegetables irrigated with sewage water is poor and not fit for human health, evident from the high concentration of Pb, Cd and Cr. Urgent measures are required to prevent consumption and production vegetables irrigated with of sewage water in the study area.

  7. Municipal solid waste management health risk assessment from air emissions for China by applying life cycle analysis.

    Science.gov (United States)

    Li, Hua; Nitivattananon, Vilas; Li, Peng

    2015-05-01

    This study is to quantify and objectively evaluate the extent of environmental health risks from three waste treatment options suggested by the national municipal solid waste management enhancing strategy (No [2011] 9 of the State Council, promulgated on 19 April 2011), which includes sanitary landfill, waste-to-energy incineration and compost, together with the material recovery facility through a case study in Zhangqiu City of China. It addresses potential chronic health risks from air emissions to residential receptors in the impacted area. It combines field survey, analogue survey, design documents and life cycle inventory methods in defining the source strength of chemicals of potential concern. The modelling of life cycle inventory and air dispersion is via integrated waste management(IWM)-2 and Screening Air Dispersion Model (Version 3.0) (SCREEN3). The health risk assessment is in accordance with United States Environmental Protection Agency guidance Risk Assessment Guidance for Superfund (RAGS), Volume I: Human Health Evaluation Manual (Part F, Supplemental Guidance for Inhalation Risk Assessment). The exposure concentration is based on long-term exposure to the maximum ground level contaminant in air under the 'reasonable worst situation' emissions and then directly compared with reference for concentration and unit risk factor/cancer slope factor derived from the national air quality standard (for a conventional pollutant) and toxicological studies (for a specific pollutant). Results from this study suggest that the option of compost with material recovery facility treatment may pose less negative health impacts than other options; the sensitivity analysis shows that the landfill integrated waste management collection rate has a great influence on the impact results. Further investigation is needed to validate or challenge the findings of this study.

  8. Data warehouse for assessing animal health, welfare, risk management and -communication.

    Science.gov (United States)

    Nielsen, Annette Cleveland

    2011-01-01

    The objective of this paper is to give an overview of existing databases in Denmark and describe some of the most important of these in relation to establishment of the Danish Veterinary and Food Administrations' veterinary data warehouse. The purpose of the data warehouse and possible use of the data are described. Finally, sharing of data and validity of data is discussed. There are databases in other countries describing animal husbandry and veterinary antimicrobial consumption, but Denmark will be the first country relating all data concerning animal husbandry, -health and -welfare in Danish production animals to each other in a data warehouse. Moreover, creating access to these data for researchers and authorities will hopefully result in easier and more substantial risk based control, risk management and risk communication by the authorities and access to data for researchers for epidemiological studies in animal health and welfare.

  9. Human health risk assessment with spatial analysis: Study of a population chronically exposed to arsenic through drinking water from Argentina

    Energy Technology Data Exchange (ETDEWEB)

    Navoni, J.A., E-mail: jnavoni@ffyb.uba.ar [Cátedra de Toxicología y Química Legal, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, C1113AAD Ciudad Autónoma de Buenos Aires (Argentina); De Pietri, D., E-mail: depietrid@hotmail.com [Dirección Nacional de Determinantes de la Salud e Investigación, Ministerio de Salud de la Nación, Av. 9 de Julio 1925, C1073ABA Ciudad Autónoma de Buenos Aires (Argentina); Olmos, V. [Cátedra de Toxicología y Química Legal, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, C1113AAD Ciudad Autónoma de Buenos Aires (Argentina); Gimenez, C. [Cátedra Química Analítica I, Universidad Nacional del Chaco Austral. Cmte., Fernández 755 (3700), Pres. Roque Sáenz Peña, Chaco (Argentina); Bovi Mitre, G. [Grupo INQA (Investigación Química Aplicada) Facultad de Ciencias Agrarias, Universidad Nacional de Jujuy, Alberdi 47, piso 1, San Salvador de Jujuy, Jujuy CP 4600 (Argentina); and others

    2014-11-15

    Arsenic (As) is a ubiquitous element widely distributed in the environment. This metalloid has proven carcinogenic action in man. The aim of this work was to assess the health risk related to As exposure through drinking water in an Argentinean population, applying spatial analytical techniques in addition to conventional approaches. The study involved 650 inhabitants from Chaco and Santiago del Estero provinces. Arsenic in drinking water (Asw) and urine (UAs) was measured by hydride generation atomic absorption spectrophotometry. Average daily dose (ADD), hazard quotient (HQ), and carcinogenic risk (CR) were estimated, geo-referenced and integrated with demographical data by a health composite index (HI) applying geographic information system (GIS) analysis. Asw covered a wide range of concentration: from non-detectable (ND) to 2000 μg/L. More than 90% of the population was exposed to As, with UAs levels above the intervention level of 100 μg/g creatinine. GIS analysis described an expected level of exposure lower than the observed, indicating possible additional source/s of exposure to inorganic arsenic. In 68% of the locations, the population had a HQ greater than 1, and the CR ranged between 5·10{sup −5} and 2,1·10{sup −2}. An environmental exposure area through ADD geo-referencing defined a baseline scenario for space-time risk assessment. The time of residence, the demographic density and the potential health considered outcomes helped characterize the health risk in the region. The geospatial analysis contributed to delimitate and analyze the change tendencies of risk in the region, broadening the scopes of the results for a decision-making process. - Highlights: • Risk assessment (RA) to As using deterministic procedures • Integration of RA through deterministic procedures with GIS tools • Analysis of the time-space behavior of the risk area • Analysis of As effect outcomes through HI • Broaden the scopes of deterministic approaches.

  10. [Assessment of children's health risk posed by traffic-related air pollution as exemplified by the city of Salekhard].

    Science.gov (United States)

    Lezhnin, V L; Konshina, L G; Sergeyeva, M V

    2014-01-01

    With the aim of determination of the levels of children's health risk from chemical air pollution caused by vehicle emissions, on the territory of the municipal district of the city of Salekhard there was carried out the work on the study of the intensity and the chemical structure of traffic-related air pollution in the locations of 16 children's preschool institutions. There was used the technique of the counting campaign for the structure and intensity of road traffic flows, children's health detriment was calculated according to the method of risk assessment. The main danger in the emissions of vehicles is belonged to nitrogen dioxide (43.6%), benzo(a)pyrene (37.4%), carbon monoxide (6.57%), formaldehyde (4.43%). Being detected at the level of I0(-4)-10(-5) and corresponding to the maximum permissible risk estimated cancer risk is a subject for continuous monitoring.

  11. mHealth and mobile medical Apps: a framework to assess risk and promote safer use.

    Science.gov (United States)

    Lewis, Thomas Lorchan; Wyatt, Jeremy C

    2014-09-15

    The use of mobile medical apps by clinicians and others has grown considerably since the introduction of mobile phones. Medical apps offer clinicians the ability to access medical knowledge and patient data at the point of care, but several studies have highlighted apps that could compromise patient safety and are potentially dangerous. This article identifies a range of different kinds of risks that medical apps can contribute to and important contextual variables that can modify these risks. We have also developed a simple generic risk framework that app users, developers, and other stakeholders can use to assess the likely risks posed by a specific app in a specific context. This should help app commissioners, developers, and users to manage risks and improve patient safety.

  12. A GIS-based human health risk assessment for urban green space planning--an example from Grugliasco (Italy).

    Science.gov (United States)

    Poggio, Laura; Vrscaj, Borut

    2009-11-15

    The need to develop approaches for risk-based management of soil contamination, as well as the integration of the assessment of the human health risk (HHR) due to the soil contamination in the urban planning procedures has been the subject of recent attention of scientific literature and policy makers. The spatial analysis of environmental data offers multiple advantages for studying soil contamination and HHR assessment, facilitating the decision making process. The aim of this study was to explore the possibilities and benefits of spatial implementation of a quantitative HHR assessment methodology for a planning case in a typical urban environment where the soil is contaminated. The study area is located in the city of Grugliasco a part of the Turin (Italy) metropolitan area. The soils data were derived from a site specific soil survey and the land-use data from secondary sources. In the first step the soil contamination data were geo-statistically analysed and a spatial soil contamination data risk modelling procedure designed. In order to spatially assess the HHR computer routines were developed using GIS raster tools. The risk was evaluated for several different land uses for the planned naturalistic park area. The HHR assessment indicated that the contamination of soils with heavy metals in the area is not sufficient to induce considerable health problems due to typical human behaviour within the variety of urban land uses. An exception is the possibility of direct ingestion of contaminated soil which commonly occurs in playgrounds. The HHR evaluation in a planning case in the Grugliasco Municipality confirms the suitability of the selected planning option. The construction of the naturalistic park presents one solution for reducing the impacts of soil contamination on the health of citizens. The spatial HHR evaluation using GIS techniques is a diagnostic procedure for assessing the impacts of urban soil contamination, with which one can verify planning

  13. Seafood consumption among Chinese coastal residents and health risk assessment of heavy metals in seafood.

    Science.gov (United States)

    Zhao, Ran; Yan, Shuangshuang; Liu, Min; Wang, Bi; Hu, Dong; Guo, Dongbei; Wang, Juan; Xu, Wanting; Fan, Chun

    2016-08-01

    The aims of the present study were to obtain the seafood dietary patterns of coastal residents, to determine the concentrations of heavy metals, and to evaluate the possible health risks caused by seafood intake. The daily food intakes of 24 types of seafood were collected from 738 participants from Xiamen, a southern Chinese coastal city, using food frequency questionnaire (FFQ) and dietary history method. One hundred and fifty-six samples of 14 types of highest intake seafood were collected from local markets for lead (Pb), cadmium (Cd), chromium (Cr), mercury (Hg), and arsenic (As) determination. Health risks via seafood consumption were evaluated by calculating the target hazard quotient (THQ) and the total hazard index (HI) for carcinogenic and non-carcinogenic effects recommended by the US Environmental Protection Agency. The results showed that the seafood daily intake of Xiamen residents was 61.5 (2.14, 115) g/day. The concentrations of Pb, Cd, Cr, Hg, and As in seafood were ND-0.45 mg/kg, ND-0.19 mg/kg, ND-0.80 mg/kg, ND-0.70 mg/kg, and 0.32-16.9 mg/kg, respectively. Concentrations of Cd and As in some samples were higher than national limitation standards. Consumption of 14 common types of seafood would not pose non-carcinogenic risk. However, some types, such as sparuslatus, oyster, and porphyra tenera, would form a carcinogenic risk. Regardless of a carcinogenic or non-carcinogenic risk, As posed the highest risk on humans. The observed HI value for non-carcinogenic effect of all metals in all seafood reached 0.69-2.20, and the metal orders of risk can be listed as As > Hg > Cr > Cd > Pb, reiterating the risk of As is a matter of concern in seafood from Xiamen markets.

  14. [Interview instrument provides no reliable assessment of suicide risk. Scientific support is lacking according to report from the Swedish Council on Health Technology Assessment (SBU)].

    Science.gov (United States)

    Runeson, Bo

    2015-12-08

    Identifying individuals at risk of future suicide or suicide attempts is of clinical importance. Instruments have been developed to facilitate the assessment of the risk of future suicidal acts. A systematic review was conducted using the standard methods of the Swedish Council on Health Technology Assessment (SBU). The ability of the instrument to predict risk for future suicide/suicide attempt was assessed at follow up. The methodological quality of eligible studies was assessed; studies with moderate or low risk of bias were analysed in accordance with GRADE. None of the included studies provided scientific evidence to support that any instrument had sufficient accuracy to predict future suicidal behaviour. There is strong evidence to support that the SAD PERSONS Scale has very low sensitivity; most persons who make future suicidal acts are not identified.

  15. Industrial metal pollution in water and probabilistic assessment of human health risk.

    Science.gov (United States)

    Saha, Narottam; Rahman, M Safiur; Ahmed, Mohammad Boshir; Zhou, John L; Ngo, Huu Hao; Guo, Wenshan

    2016-10-28

    Concentration of eight heavy metals in surface and groundwater around Dhaka Export Processing Zone (DEPZ) industrial area were investigated, and the health risk posed to local children and adult residents via ingestion and dermal contact was evaluated using deterministic and probabilistic approaches. Metal concentrations (except Cu, Mn, Ni, and Zn) in Bangshi River water were above the drinking water quality guidelines, while in groundwater were less than the recommended limits. Concentration of metals in surface water decreased as a function of distance. Estimations of non-carcinogenic health risk for surface water revealed that mean hazard index (HI) values of As, Cr, Cu, and Pb for combined pathways (i.e., ingestion and dermal contact) were >1.0 for both age groups. The estimated risk mainly came from the ingestion pathway. However, the HI values for all the examined metals in groundwater were probabilistically estimated 95th percentile values of TCR exceeded the benchmark, mean TCR values were less than 1 × 10(-4). Simulated results showed that 20.13% and 5.43% values of TCR for surface water were >1 × 10(-4) for adult and children, respectively. Deterministic and probabilistic estimations of cancer risk through exposure to groundwater were well below the safety limit. Overall, the population exposed to Bangshi River water remained at carcinogenic and non-carcinogenic health threat and the risk was higher for adults. Sensitivity analysis identified exposure duration (ED) and ingestion rate (IR) of water as the most relevant variables affecting the probabilistic risk estimation model outcome.

  16. Environmental Exposure to Cadmium: Health Risk Assessment and its Associations with Hypertension and Impaired Kidney Function

    Science.gov (United States)

    Wu, Haiyun; Liao, Qilin; Chillrud, Steven N.; Yang, Qiang; Huang, Lei; Bi, Jun; Yan, Beizhan

    2016-07-01

    Cadmium (Cd) is a toxic metal. This study was aimed to estimate the potential health risks in a Cd-polluted district in China, and examine the relationship between urinary cadmium(UCd) and hypertension and impaired kidney function at low exposure levels (UCd: GM 1.3 μg/g creatinine). Blood pressure measurement, questionnaires, and collection of urinary samples were conducted from 217 residents. Environmental samples, food, and cigarette samples were collected and detected to estimate the risks posed by Cd and the contribution of inhalation, ingestion, and dermal contact pathways to these risks. A logistic regression model was used in examining associations between exposure and hypertension and impaired kidney function. Results show that this population is at high risk. For non-smokers, incremental lifetime cancer risk (ILCR) and hazard quotient (HQ) are 1.74E-04 and 2.96, and for smokers, they are 1.07E-03 and 52.5, respectively. Among all exposure pathways, smoking and foods cause the major increases in ILCR and HQ. UCd is significantly associated with hypertension (odds ratio (OR) = 1.468 95% confidence interval (CI): 1.104, 1.953; P = 0.008) and impaired kidney function (OR = 1.902, 95% CI: 1.054, 3.432; P = 0.033). The results demonstrate that Cd can potentially lead to adverse health effects.

  17. Occurrence, distribution, and dechlorination of polychlorinated biphenyls and health risk assessment in Selangor River basin.

    Science.gov (United States)

    Sakai, Nobumitsu; Dayana, Emmy; Abu Bakar, Azizi; Yoneda, Minoru; Nik Sulaiman, Nik Meriam; Ali Mohd, Mustafa

    2016-10-01

    Polychlorinated biphenyls (PCBs) were monitored in surface water collected in the Selangor River basin, Malaysia, to identify the occurrence, distribution, and dechlorination process as well as to assess the potential adverse effects to the Malaysian population. Ten PCB homologs (i.e., mono-CBs to deca-CBs) were quantitated by using gas chromatography-mass spectrometry (GC/MS). The total concentration of PCBs in the 10 sampling sites ranged from limit of detection to 7.67 ng L(-1). The higher chlorinated biphenyls (tetra-CBs to deca-CBs) were almost not detected in most of the sampling sites, whereas lower chlorinated biphenyls (mono-CBs, di-CBs, and tri-CBs) dominated more than 90 % of the 10 homologs in all the sampling sites. Therefore, the PCB load was estimated to be negligible during the sampling period because PCBs have an extremely long half-life. The PCBs, particularly higher chlorinated biphenyls, could be thoroughly dechlorinated to mono-CBs to tri-CBs by microbial decomposition in sediment or could still be accumulated in the sediment. The lower chlorinated biphenyls, however, could be resuspended or desorbed from the sediment because they have faster desorption rates and higher solubility, compared to the higher chlorinated biphenyls. The health risk for the Malaysia population by PCB intake that was estimated from the local fish consumption (7.2 ng kg(-1) bw day(-1)) and tap water consumption (1.5 × 10(-3)-3.1 × 10(-3) ng kg(-1) bw day(-1)) based on the detected PCB levels in the surface water was considered to be minimal. The hazard quotient based on the tolerable daily intake (20 ng kg(-1) bw day(-1)) was estimated at 0.36.

  18. Drinking water studies: a review on heavy metal, application of biomarker and health risk assessment (a special focus in Malaysia).

    Science.gov (United States)

    Ab Razak, Nurul Hafiza; Praveena, Sarva Mangala; Aris, Ahmad Zaharin; Hashim, Zailina

    2015-12-01

    Malaysia has abundant sources of drinking water from river and groundwater. However, rapid developments have deteriorated quality of drinking water sources in Malaysia. Heavy metal studies in terms of drinking water, applications of health risk assessment and bio-monitoring in Malaysia were reviewed from 2003 to 2013. Studies on heavy metal in drinking water showed the levels are under the permissible limits as suggested by World Health Organization and Malaysian Ministry of Health. Future studies on the applications of health risk assessment are crucial in order to understand the risk of heavy metal exposure through drinking water to Malaysian population. Among the biomarkers that have been reviewed, toenail is the most useful tool to evaluate body burden of heavy metal. Toenails are easy to collect, store, transport and analysed. This review will give a clear guidance for future studies of Malaysian drinking water. In this way, it will help risk managers to minimize the exposure at optimum level as well as the government to formulate policies in safe guarding the population.

  19. 'Gay boy talk' meets 'girl talk': HIV risk assessment assumptions in young gay men's sexual health communication with best friends.

    Science.gov (United States)

    Mutchler, Matt G; McDavitt, Bryce

    2011-06-01

    Young adults, particularly young gay men (YGM), are vulnerable to human immunodeficiency virus (HIV). Yet, little is known about how YGM discuss sexual health issues with their friends ('gay boy talk'). We conducted semi-structured interviews with YGM and their best friends (11 YGM/YGM dyads and 13 YGM/heterosexual female dyads). In this paper, we examine risk assessment assumptions conveyed within YGM's communication about sexual health with their friends and how, if at all, the sexual scripts guiding these assumptions may differ between YGM and young women. Findings demonstrated that, while these young adults clearly intended to support their friends and promote safer sex, they also conveyed assumptions about HIV risk assessment, especially regarding sexual partner selection, that may actually increase their friends' risk for HIV infection. Since inaccurate HIV risk assessment assumptions were transmitted via sexual health communication between peers, it is suggested that such assumptions may need to be addressed in HIV prevention programs working with YGM and their friends. Further, gender differences were identified within the sexual scripts shared between YGM and their friends, suggesting that such interventions should be tailored to the specific needs of different friendship networks.

  20. Stage of change is associated with assessment of the health risks of maternal smoking among pregnant women.

    Science.gov (United States)

    Haslam, C; Draper, E

    2000-10-01

    This study explored pregnant women's assessment of the health risks associated with maternal smoking. The aim was to determine if stage of change relating to smoking is associated with risk assessment. A cross-sectional survey (employing a self-completion questionnaire) was conducted of all women who attended antenatal clinics at Leicester Royal Infirmary, National Health Service Trust, UK over a 2 week period. Questionnaires were completed by 254 respondents. Twenty seven percent of non-smokers agreed with more than 75% of a series of statements about the dangers of maternal smoking compared to 5% of smokers and 44% of women in social class I (highest social class) agreed with more than 75% of the statements compared with only 10% of women in social classes IV and V (lower social class groups). Married women were twice as likely to concur with more than 75% of the health risks compared to single or cohabiting women and 29% of women intending to breastfeed agreed with more than 75% of the statements compared with only 8.7% of women not intending to breastfeed. There was no significant effect of age, whether the pregnancy was planned, previous obstetric complications or whether the woman had a child with asthma or respiratory infections. A multiple regression analysis indicated that smokers were much less likely to agree with the health risks than their non-smoking counterparts (p = 0.034). Stage of change was related to both the number of health risks agreed with and the level of conviction. A woman's stage of change could be assessed at the start of antenatal care so that appropriate smoking cessation advice can be offered.

  1. Environmental health-risk assessment for tritium releases from the National Tritium Labeling Facility (NTLF) at Lawrence Berkeley Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    McKone, T.E.; Brand, K.P.

    1994-12-01

    This report is a health risk assessment that addresses continuous releases of tritium to the environment from the National Tritium Labeling Facility (NTLF) at the Lawrence Berkeley Laboratory (LBL). The NTLF contributes approximately 95% of all tritium releases from LBL. Transport and transformation models were used to determine the movement of tritium releases from the NRLF to the air, surface water, soils, and plants and to determine the subsequent doses to humans. These models were calibrated against environmental measurements of tritium levels in the vicinity of the NTLF and in the surrounding community. Risk levels were determined for human populations in each of these zones. Risk levels to both individuals and populations were calculated. In this report population risks and individual risks were calculated for three types of diseases--cancer, heritable genetic effects, and developmental and reproductive effects.

  2. Health risk assessment from contaminated foodstuffs: a field study in chromite mining-affected areas northern Pakistan.

    Science.gov (United States)

    Nawab, Javed; Li, Gang; Khan, Sardar; Sher, Hassan; Aamir, Muhammad; Shamshad, Isha; Khan, Anwarzeb; Khan, Muhammad Amjad

    2016-06-01

    This study aimed to investigate the potential health risk associated with toxic metals in contaminated foodstuffs (fruits, vegetables, and cereals) collected from various agriculture fields present in chromite mining-affected areas of mafic and ultramafic terrains (northern Pakistan). The concentrations of Cr, Ni, Zn, Cd, and Pb were quantified in both soil and food samples. The soil samples were highly contaminated with Cr (320 mg/kg), Ni (108 mg/kg), and Cd (2.55 mg/kg), which exceeded their respective safe limits set by FAO/WHO. Heavy metal concentrations in soil were found in the order of Cr>Ni>Pb>Zn>Cd and showed significantly (p risk assessment revealed no potential risk for both adults and children for the majority of heavy metals, except Cd, which showed health risk index (HRI) >1 for children and can pose potential health threats for local inhabitants. Graphical Abstract Heavy metals released from chromite mining lead to soil and foodstuff contamination and human health risk.

  3. [Application of ICP-mS in the health risk assessment of heavy metals for drinking water sources in reservoirs].

    Science.gov (United States)

    Gao, Bo; Li, Qiang; Zhou, Huai-Dong; Gao, Ji-Jun; Zou, Xiao-Wen; Yong, Huang

    2014-05-01

    The six heavy metal concentrations (Cr, Cr, As, Cd, Cu, Zn and Pb) in water samples collected from five reservoirs of Liao River Basin were studied. The health risk assessment for heavy metals pollution in reservoirs was conducted based on the environmental health risk assessment model recommended by U. S. Environmental Protection Agency. The results showed that the average concentrations of Cr, Cu, Zn, As, Cd and Pb in five reservoirs of Liao River Basin were 3.36, 1.03, 2. 70, 1.23, 0. 02 and 0. 03 microg L-1, respectively. In fact, these heavy metals concentrations were obviously lower than the Standard of National Drinking Water in China (GB 5749-2006). The results also showed that the metal carcinogenic risk was relatively high in this region. The order of the risk level of carcinogenic metals was Cr>As>Cd. The highest carcinogenic risk was from Cr, with the risk for adults ranging from 4. 50 X 10(-5) approximately 7. 53 X 10(-5) a-1' and the risk for children ranging from 6. 29 X 10(-5) to 1. 05 X 10(-4) a-1. The health risk levels caused by non-carcinogenic metals ranging from 10-13 to 10(-10) a-1 were lower than the acceptable range suggested by International Commission on Radiological Protection (ICRP) and the order of the risk level of non-carcinogenic metals was Cu>Zn>Pb. The total health risk of heavy metals for adults ranging from 1. 07X 10(-4) to 1. 72X 10(-4) a-1 and for children ranging from 1. 49 X 10(-4) to 2. 40 X 10(-4) a-1 exceeded the accepted level of 5 X 10(-5) a-1 as suggested by ICRP. The health risk levels of carcinogenic metals were significantly higher than those of non-carcinogenic metals in the reservoirs for Liao River Basin.

  4. Human Health Risk Assessment Simulations in a Distributed Environment for Shuttle Launch

    Science.gov (United States)

    Thirumalainambi, Rajkumar; Bardina, Jorge

    2004-01-01

    During the launch of a rocket under prevailing weather conditions, commanders at Cape Canaveral Air Force station evaluate the possibility of whether wind blown toxic emissions might reach civilian and military personnel in the near by area. In our model, we focused mainly on Hydrogen chloride (HCL), Nitrogen oxides (NOx) and Nitric acid (HNO3), which are non-carcinogenic chemicals as per United States Environmental Protection Agency (USEPA) classification. We have used the hazard quotient model to estimate the number of people at risk. It is based on the number of people with exposure above a reference exposure level that is unlikely to cause adverse health effects. The risk to the exposed population is calculated by multiplying the individual risk and the number in exposed population. The risk values are compared against the acceptable risk values and GO or NO-go situation is decided based on risk values for the Shuttle launch. The entire model is simulated over the web and different scenaria can be generated which allows management to choose an optimum decision.

  5. Health Risk Assessment for Inhalation Exposure to Methyl Tertiary Butyl Ether at Petrol Stations in Southern China

    Directory of Open Access Journals (Sweden)

    Dalin Hu

    2016-02-01

    Full Text Available Methyl tertiary butyl ether (MTBE, a well known gasoline additive, is used in China nationwide to enhance the octane number of gasoline and reduce harmful exhaust emissions, yet  little is known regarding the potential health risk associated with occupational exposure to MTBE in petrol stations. In this study, 97 petrol station attendants (PSAs in southern China were recruited for an assessment of the health risk associated with inhalation exposure to MTBE. The personal exposure levels of MTBE were analyzed by Head Space Solid Phase Microextraction GC/MS, and the demographic characteristics of the PSAs were investigated. Cancer and non-cancer risks were calculated with the methods recommended by the United States Environmental Protection Agency. The results showed that the exposure levels of MTBE in operating workers were much higher than among support staff (p < 0.01 and both were lower than 50 ppm (an occupational threshold limit value. The calculated cancer risks (CRs at the investigated petrol stations was 0.170 to 0.240 per 106 for operating workers, and 0.026 to 0.049 per 106 for support staff, which are below the typical target range for risk management of 1 × 10−6 to 1 × 10−4; The hazard quotients (HQs for all subjects were <1. In conclusion, our study indicates that the MTBE exposure of PSAs in southern China is in a low range which does not seem to be a significant health risk.

  6. Risk assessment and management: a community forensic mental health practice model.

    Science.gov (United States)

    Kelly, Teresa; Simmons, Warren; Gregory, Esther

    2002-12-01

    In Victoria, the Crimes (Mental Impairment and Unfitness to be Tried) Act (1997) reformed legal practice in relation to the detention, management and release of persons found by a court to be not guilty on the grounds of insanity or unfit to be tried. This Act provides a legal structure for such 'forensic patients' to move from secure inpatient facilities into the community. This new legislative landscape has generated challenges for all stakeholders and has provided the impetus for the development of a risk assessment and management model. The key components of the model are the risk profile, assessment and management plan. The discussion comprises theory, legislation, practice implications and limitations of the model. Practice implications concern the provision of objective tools, which identify risk and document strategic interventions to support clinical management. Some of the practice limitations include the model's applicability to risk assessment and management and its dependence on a mercurial multi-service interface in after-hours crisis situations. In addition to this, the paper articulates human limitations implicit in the therapeutic relationship that necessarily underpins the model. The paper concludes with an exploration of the importance of evaluative processes as well as the need for formal support and education for clinicians.

  7. Health risk assessment based on anthropometric indicators in men in New Belgrade

    Directory of Open Access Journals (Sweden)

    Stanković Veroslava

    2013-12-01

    Full Text Available Introduction: There is little data on the association of metabolic syndrome and health status in Serbian men, so our intention was to investigate the prevalence of the metabolic syndrome in men with no history of diabetes or cardiovascular disease in New Belgrade, Serbia; to determine which of the anthropometric parameters (body mass index - BMI and waist circumference - WC is best for the evaluation of health risks in primary care, especially the risk factors for metabolic syndrome. Research Methods and Procedures: The study involved 132 healthy men ages 44.73 ± 9.37 years. Anthropometric values were measured in all the patients. Blood pressure, blood biochemistry (high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglycerides, blood glucose and analysis of their medical records were also done. Analysis of consistency has been used in testing hypothesis. Results: The sample consisted of 132 patients with mean age 44.73 ± 9.37 years. The prevalence of the metabolic syndrome was 44.7%. Analysis of consistence showed differences in the combined predictive ability of anthropometric indicators and other factors of MetS. Conclusions: BMI and WC are the simple measures of adiposity most strongly associated with metabolic abnormalities. Our findings suggest that WC can not be used as a complementary measurement to identify health risks in any group of men.

  8. Health Risk Assessment of Heavy Metals in Soils from Witwatersrand Gold Mining Basin, South Africa.

    Science.gov (United States)

    Kamunda, Caspah; Mathuthu, Manny; Madhuku, Morgan

    2016-01-01

    The study evaluates the health risk caused by heavy metals to the inhabitants of a gold mining area. In this study, 56 soil samples from five mine tailings and 17 from two mine villages were collected and analyzed for Asernic (As), Lead (Pb), Mercury (Hg), Cadmium (Cd), Chromium (Cr), Cobalt (Co), Nickel (Ni), Copper (Cu) and Zinc (Zn) using ICP-MS. Measured concentrations of these heavy metals were then used to calculate the health risk for adults and children. Their concentrations were such that Cr > Ni > As > Zn > Cu > Co > Pb > Hg > Cd, with As, Cr and Ni higher than permissible levels. For the adult population, the Hazard Index value for all pathways was found to be 2.13, making non-carcinogenic effects significant to the adult population. For children, the Hazard Index value was 43.80, a value >1, which poses serious non-carcinogenic effect to children living in the gold mining area. The carcinogenic risk was found to be 1.7 × 10(-4) implying that 1 person in every 5882 adults may be affected. In addition, for children, in every 2725 individuals, 1 child may be affected (3.67 × 10(-4)). These carcinogenic risk values were both higher than acceptable values.

  9. Particulate Matter and Health Risk under a Changing Climate: Assessment for Portugal

    Directory of Open Access Journals (Sweden)

    Daniela Dias

    2012-01-01

    Full Text Available The potential impacts of climate-induced changes in air pollution levels and its impacts on population health were investigated. The IPCC scenario (SRES A2 was used to analyse the effects of climate on future PM10 concentrations over Portugal and their impact on short-term population exposure and mortality. The air quality modelling system has been applied with high spatial resolution looking on climate changes at regional scale. To quantify health impacts related to air pollution changes, the WHO methodology for health impact assessment was implemented. The results point to 8% increase of premature mortality attributed to future PM10 levels in Portugal. The pollution episodes with daily average PM10 concentration above the current legislated value (50 μg·m−3 would be responsible for 81% of attributable cases. The absolute number of deaths attributable to PM10 under future climate emphasizes the importance of indirect effects of climate change on human health.

  10. Air pollution, health and social deprivation: A fine-scale risk assessment.

    Science.gov (United States)

    Morelli, Xavier; Rieux, Camille; Cyrys, Josef; Forsberg, Bertil; Slama, Rémy

    2016-05-01

    Risk assessment studies often ignore within-city variations of air pollutants. Our objective was to quantify the risk associated with fine particulate matter (PM2.5) exposure in 2 urban areas using fine-scale air pollution modeling and to characterize how this risk varied according to social deprivation. In Grenoble and Lyon areas (0.4 and 1.2 million inhabitants, respectively) in 2012, PM2.5 exposure was estimated on a 10×10m grid by coupling a dispersion model to population density. Outcomes were mortality, lung cancer and term low birth weight incidences. Cases attributable to air pollution were estimated overall and stratifying areas according to the European Deprivation Index (EDI), taking 10µg/m(3) yearly average as reference (counterfactual) level. Estimations were repeated assuming spatial homogeneity of air pollutants within urban area. Median PM2.5 levels were 18.1 and 19.6μg/m(3) in Grenoble and Lyon urban areas, respectively, corresponding to 114 (5.1% of total, 95% confidence interval, CI, 3.2-7.0%) and 491 non-accidental deaths (6.0% of total, 95% CI 3.7-8.3%) attributable to long-term exposure to PM2.5, respectively. Attributable term low birth weight cases represented 23.6% of total cases (9.0-37.1%) in Grenoble and 27.6% of cases (10.7-42.6%) in Lyon. In Grenoble, 6.8% of incident lung cancer cases were attributable to air pollution (95% CI 3.1-10.1%). Risk was lower by 8 to 20% when estimating exposure through background stations. Risk was highest in neighborhoods with intermediate to higher social deprivation. Risk assessment studies relying on background stations to estimate air pollution levels may underestimate the attributable risk.

  11. Human and animal health risk assessment of metal contamination in soil and plants from Ait Ammar abandoned iron mine, Morocco.

    Science.gov (United States)

    Nouri, Mohamed; Haddioui, Abdelmajid

    2016-01-01

    The goal of this paper is to investigate metal pollution in food chain and assess the resulting health risks to native citizens in Ait Ammar village. The results showed that cadmium (Cd), lead (Pb), and copper (Cu) concentrations in animal organs were above the metal concentration safety limit. Nevertheless, soils and plants from mining area were contaminated with iron (Fe), chromium (Cr), zinc (Zn), and Cr, Cu, Zn respectively. Cd concentrations in almost animal organs were higher than the acceptable daily upper limit, suggesting human consumption of this livestock meat and offal may pose a health risk. The estimated intake of Pb and Cd for Ait Ammar population could be a cause of concern because it exceeded the Provisional Tolerable Weekly Intake (PTWI) proposed by Joint Expert Committee on Food Additives (JECFA) in this area. Thus, conducting regular periodic studies to assess the dietary intake of mentioned elements are recommended.

  12. Assessment of volatile organic compounds and particulate matter in a dental clinic and health risks to clinic personnel.

    Science.gov (United States)

    Hong, Yu-Jue; Huang, Yen-Ching; Lee, I-Long; Chiang, Che-Ming; Lin, Chitsan; Jeng, Hueiwang Anna

    2015-01-01

    This study was conducted to assess (1) levels of volatile organic compounds (VOCs) and particulate matter (PM) in a dental clinic in southern Taiwan and (2) dental care personnel's health risks associated with due to chronic exposure to VOCs. An automatic, continuous sampling system and a multi-gas monitor were employed to quantify the air pollutants, along with environmental comfort factors, including temperature, CO2, and relative humidity at six sampling sites in the clinic over eight days. Specific VOC compounds were identified and their concentrations were quantified. Both non-carcinogenic and carcinogenic VOC compounds were assessed based on the US Environmental Protection Agency's Principles of Health Risk Assessment in terms of whether those indoor air pollutants increased health risks for the full-time dental care professionals at the clinic. Increased levels of VOCs were recorded during business hours and exceeded limits recommended by the Taiwan Environmental Protection Agency. A total of 68 VOC compounds were identified in the study area. Methylene methacrylate (2.8 ppm) and acetone (0.176 ppm) were the only two non-carcinogenic compounds that posed increased risks for human health, yielding hazard indexes of 16.4 and 4.1, respectively. None of the carcinogenic compounds increased cancer risk. All detected PM10 levels ranged from 20 to 150 μg/m(3), which met the Taiwan EPA and international limits. The average PM10 level during business hours was significantly higher than that during non-business hours (P = 0.04). Improved ventilation capacity in the air conditioning system was recommended to reduce VOCs and PM levels.

  13. Geochemistry and health risk assessment of arsenic exposure to street dust in the zinc smelting district, Northeast China.

    Science.gov (United States)

    Xu, Sujuan; Zheng, Na; Liu, Jingshuang; Wang, Yang; Chang, Shouzhi

    2013-02-01

    The aim of this study was to investigate arsenic (As) accumulation in street dust and health risk of population. The investigation concentrated on: a. pollution levels of As in street dust; b. spatial distribution of As in street dust; c. physicochemical properties analysis of street dust; and d. assessment of population health risk due to As exposure to street dust. As concentration in street dust ranged from 3.33 to 185.1 mg kg(-1), with a mean of 33.10 mg kg(-1), which was higher than the background value of Liaoning soil. As contamination level of the area closing to Huludao Zinc Plant (HZP) was highest. Spatial variation showed that the pollution center was close to HZP, formed radial distribution pattern and extended to the northeast and southwest of HZP. The pH and organic matter of street dust were both higher than the background values of soil in Liaoning. There was significantly negative correlation between As concentration and the pH. The mass percentages of particles 180-100, 63, and 63 μm were 29.8, 3.7, 21.3, and 4.2 %, respectively. The highest of As concentration was found in the smallest particle size (63 μm). As loadings in the particles of grain size 180-100 and 63 μm were higher than other particle fractions. Results of the risk assessment indicated that the highest risk was associated with the ingestion of street dust particles. Health risk for different use scenarios to human decreased in the order of HZP > Industrial district > School > Commercial center > Residential area. Around HZP, Hazard Index (HI) for children and cancer risk of As by street dust exposure exceeded the acceptable values. It indicated that there was a potential adverse effect on children health by As exposure to the street dust of Huludao.

  14. Congener specific distribution and health risk assessment of polychlorinated biphenyls in urban soils

    Directory of Open Access Journals (Sweden)

    Bhupander Kumar

    2012-10-01

    Full Text Available Polychlorinated biphenyls (PCBs were primarily used in transformers and capacitors, lubricants, flame retardants, plasticizers, paint, carbonless papers, etc. These are capable of long-range atmospheric transport and have been designated as persistent organic pollutants by the Stockholm Convention. Due to their characteristic properties, PCBs are found worldwide in all environmental matrices (including human and biota. Soils are usually considered to be the source as well as sink for environmental pollutants, with cumulative effects of long-range atmospheric transport and local sources. Around the world, comparatively higher concentrations of PCBs have been reported in urban soils than suburban or rural soils. Higher amount of PCBs in urban soils may cause toxicological health risks to urban residents through ingestion, inhalation and skin contact. This paper presents the PCB distribution in soils from Delhi, India, and exposure risk estimates for human health through soil ingestion. The concentration of ΣPCBs ranged between 1.08-100.67 ng g–1 (mean 21.16 ng g–1±5.24 ng g–1, which was much lower than the Canadian soil quality guideline value of 1.3 mg/kg or 1300 ng g–1. Human health risk estimates through the soil ingestion pathway were made in terms of lifetime average daily dose (LADD, incremental lifetime cancer risks and non-carcinogenic hazard quotient (HQ. The LADD for Delhi adults and children was 3.02x10–8 mg kg–1 d–1 and 1.57x10–7 mg kg–1 d–1, respectively, which corresponds to toxic equivalent quotients (TEQ intake of 0.105 pg TEQ kg–1 d–1 (0.735 pg TEQ kg–1 week–1 and 0.543 pg TEQ kg–1 d–1 (3.801 pg TEQ kg–1 week–1, respectively. The estimated LADD for Delhi residents was lower than the acceptable

  15. Pollution characteristics and health risk assessment of volatile organic compounds emitted from different plastic solid waste recycling workshops.

    Science.gov (United States)

    He, Zhigui; Li, Guiying; Chen, Jiangyao; Huang, Yong; An, Taicheng; Zhang, Chaosheng

    2015-04-01

    The pollution profiles of volatile organic compounds (VOCs) emitted from different recycling workshops processing different types of plastic solid waste (PSW) and their health risks were investigated. A total of 64 VOCs including alkanes, alkenes, monoaromatics, oxygenated VOCs (OVOCs), chlorinated VOCs (ClVOCs) and acrylonitrile during the melting extrusion procedure were identified and quantified. The highest concentration of total VOCs (TVOC) occurred in the poly(acrylonitrile-butadiene styrene) (ABS) recycling workshop, followed by the polystyrene (PS), polypropylene (PP), polyamide (PA), polyvinyl chloride (PVC), polyethylene (PE) and polycarbonate (PC) workshops. Monoaromatics were found as the major component emitted from the ABS and PS recycling workshops, while alkanes were mainly emitted from the PE and PP recycling processes, and OVOCs from the PVC and PA recycling workshops. According to the occupational exposure limits' (OEL) assessment, the workers suffered acute and chronic health risks in the ABS and PS recycling workshops. Meanwhile, it was found that most VOCs in the indoor microenvironments were originated from the melting extrusion process, while the highest TVOC concentration was observed in the PS rather than in the ABS recycling workshop. Non-cancer hazard indices (HIs) of all individual VOCs were <1.0, whereas the total HI in the PS recycling workshop was 1.9, posing an adverse chronic health threat. Lifetime cancer risk assessment suggested that the residents also suffered from definite cancer risk in the PS, PA, ABS and PVC recycling workshops.

  16. Human health risk assessment of dissolved metals in groundwater and surface waters in the Melen watershed, Turkey.

    Science.gov (United States)

    Çelebi, Ahmet; Sengörür, Bülent; Kløve, Bjørn

    2014-01-01

    Determination of metal risk levels in potable water and their effects on human health are vital in assessment of water resources. Risk assessment of metals to human health in a watershed, which has not been studied before, is the main objective of the present study. Surface and groundwater sampling was carried out between September 2010 and August 2011 in the Melen Watershed, Turkey, an important drinking water resource for millions of people. Metals were analyzed in the laboratory using inductively coupled plasma. Of the 26 different metals monitored, Al, B, Ba, Cr, Cu, Fe, Mn, Mo and V were found in surface water and As, B, Ba, Cr, Cu, Mn, Mo, V and Zn in groundwater. In groundwater, unitless hazard quotient (HQ) values were 6 for As, 2.7 for Mn and 1 for Zn, while in surface water all metals were below the risk level (HQ watersheds can pose a risk to human health and that potential carcinogenic impacts should receive more attention.

  17. Grouping chemicals for health risk assessment: A text mining-based case study of polychlorinated biphenyls (PCBs).

    Science.gov (United States)

    Ali, Imran; Guo, Yufan; Silins, Ilona; Högberg, Johan; Stenius, Ulla; Korhonen, Anna

    2016-01-22

    As many chemicals act as carcinogens, chemical health risk assessment is critically important. A notoriously time consuming process, risk assessment could be greatly supported by classifying chemicals with similar toxicological profiles so that they can be assessed in groups rather than individually. We have previously developed a text mining (TM)-based tool that can automatically identify the mode of action (MOA) of a carcinogen based on the scientific evidence in literature, and it can measure the MOA similarity between chemicals on the basis of their literature profiles (Korhonen et al., 2009, 2012). A new version of the tool (2.0) was recently released and here we apply this tool for the first time to investigate and identify meaningful groups of chemicals for risk assessment. We used published literature on polychlorinated biphenyls (PCBs)-persistent, widely spread toxic organic compounds comprising of 209 different congeners. Although chemically similar, these compounds are heterogeneous in terms of MOA. We show that our TM tool, when applied to 1648 PubMed abstracts, produces a MOA profile for a subgroup of dioxin-like PCBs (DL-PCBs) which differs clearly from that for the rest of PCBs. This suggests that the tool could be used to effectively identify homogenous groups of chemicals and, when integrated in real-life risk assessment, could help and significantly improve the efficiency of the process.

  18. A health risk assessment of Arabian incense (Bakhour) smoke in the United Arab Emirates.

    Science.gov (United States)

    Dalibalta, Sarah; Elsayed, Yehya; Alqtaishat, Fareedah; Gomes, Ioline; Fernandes, Nagelle

    2015-04-01

    Burning Arabian incense (Bakhour) is a common practice in the Middle East and Arabian Gulf. Although the incense generates large amounts of chemicals and air pollutants, little is known with regard to the nature of these chemicals and their potential health risks. The aim of this study is to provide a comprehensive characterization of the chemical constituents emitted in Bakhour smoke, and subsequently to examine the associated health implications of these components. Thermo-gravimetric analysis was used to investigate the presence and the thermal profile of volatile organic compounds in three different samples of Bakhour smoke. Thermal desorption-gas chromatography-mass spectrometry was then applied to isolate all the volatile and semi-volatile compounds present in the Bakhour smoke samples. Using a spectral library and an extensive literature search, all organic compounds detected were analyzed for potential health risks. A total of 859 compounds were emitted from burning the different Bakhour samples. The novel finding of this research shows that 42 detected compounds are suspected/known carcinogens, 20 are known to have toxic effects, and at least 200 compounds are known irritants to the eyes, skin, respiratory and digestive tracts, as reported in human and/or animal studies. Our study suggests that inhaled Bakhour smoke contains a substantial number of adverse compounds, which are known to be detrimental to human health. Moreover, the evidence presented shows that incense burning is a significant source of environmental pollution; with the potential of significant health concerns particularly with long term exposure. As the majority of the compounds detected have no reported clinical data, there is an urgent need for significant research in this field.

  19. Health Risk Assessment Research on Heavy Metals Ingestion Through Groundwater Drinking Pathway for the Residents in Baotou, China.

    Science.gov (United States)

    Bai, Liping; Wang, Yeyao; Guo, Yongli; Zhou, Youya; Liu, Li; Yan, Zengguang; Li, Fasheng; Xie, Xuefeng

    2016-01-01

    Drinking groundwater is a significant pathway for human exposure to heavy metals. To evaluate the health effect of some heavy metals ingestion through the groundwater drinking pathway, the authors collected 35 groundwater samples from the drinking water wells of local residents and the exploitation wells of waterworks in Baotou, China. The monitoring results indicate that the groundwater had been polluted by heavy metals in some regions of the study area. A health risk assessment model derived from the U.S. Environmental Protection Agency was used to determine the noncarcinogenic and carcinogenic effects to residents who drink groundwater. All the respondents in the study area were at potential risk of carcinogenic health effects from arsenic when using the lowest safe standard for carcinogenic risk (1E-06). The hazard quotient values for noncarcinogenic health risk of arsenic exceeded 1 in 14.3% of the sampling wells in the study area. The research results could provide baseline data for groundwater utilization and supervision in the Baotou plain area.

  20. Bioaccumulation of Antimony and Arsenic in Vegetables and Health Risk Assessment in the Superlarge Antimony-Mining Area, China

    Directory of Open Access Journals (Sweden)

    Defang Zeng

    2015-01-01

    Full Text Available Heavy metal pollution in soils caused by mining and smelting has attracted worldwide attention for its potential health risks to residents. This paper studies the concentrations and accumulations of Sb and As in both soils and vegetables and the human health risks of Sb and As in vegetables from Xikuangshan (XKS Sb mine, Hunan, China. Results showed that the soils were severely polluted by Sb and As; Sb and As have significant positive correlation. Sb and As concentrations in vegetables were quite different: Coriandrum sativum L. was the highest in Sb, Allium fistulosum L. was the highest in As, and Brassica pekinensis L. was the lowest in both Sb and As; Daucus carota L. and Coriandrum sativum L. showed advantage in accumulating Sb and As; Coriandrum sativum L. had higher capacity of redistributing Sb and As within the plant. Health risk assessment results showed that the hazard quotient (HQ values of Sb and As in vegetables were in the ranges of 1.61–3.33 and 0.09–0.39, respectively; the chronic daily intake (CDI and hazard quotient (HQ values of Sb were over the safe limit recommended by FAO and WHO, indicating that long-term consumption of vegetables from the surrounding soils of XKS mine may bring health risks to residents.

  1. The Validity of a Brief Risk Assessment Tool for Predicting Suicidal Behavior in Veterans Utilizing VHA Mental Health Care.

    Science.gov (United States)

    Doran, Neal; De Peralta, Sharon; Depp, Colin; Dishman, Ben; Gold, Lindsay; Marshall, Robert; Miller, Dawn; Vitale, Shannon; Tiamson-Kassab, Maria

    2016-08-01

    Suicide risk among military veterans is an important and ongoing concern. The Veterans Administration (VA) mandates suicide risk screening of all veterans seen for mental health issues, but little is known about the effectiveness of this screening. A retrospective chart review to examine all suicide risk screens at VA San Diego between October and December 2012 (n = 3,365) was conducted to assess whether results were associated with suicidal behavior over the subsequent 12 months. Patients judged to be at increased risk for suicide were 3 to 16 times more likely to attempt suicide and 7 to 25 times more likely to engage in self-directed violence over the next 12 months compared with others. The screening tool may be a useful addition to clinical practice.

  2. Assessment of groundwater quality and health risk in drinking water basin using GIS.

    Science.gov (United States)

    Şener, Şehnaz; Şener, Erhan; Davraz, Ayşen

    2017-02-01

    Eğirdir Lake basin was selected as the study area because the lake is the second largest freshwater lake in Turkey and groundwater in the basin is used as drinking water. In the present study, 29 groundwater samples were collected and analyzed for physico-chemical parameters to determine the hydrochemical characteristics, groundwater quality, and human health risk in the study area. The dominant ions are Ca(2+), Mg(2+), HCO3(2-), and SO4(2). According to Gibbs plot, the predominant samples fall in the rock-water interaction field. A groundwater quality index (WQI) reveals that the majority of the samples falls under good to excellent category of water, suggesting that the groundwater is suitable for drinking and other domestic uses. The Ca-Mg-HCO3, Ca-HCO3, Ca-SO4-HCO3, and Ca-Mg-HCO3-SO4 water types are the dominant water types depending on the water-rock interaction in the investigation area. Risk of metals to human health was then evaluated using hazard quotients (HQ) by ingestion and dermal pathways for adults and children. It was indicated that As with HQ ingestion >1 was the most important pollutant leading to non-carcinogenic concerns. It can be concluded that the highest contributors to chronic risks were As and Cr for both adults and children.

  3. Pipeline risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Kariyawasam, S. [TransCanada PipeLines Ltd., Calgary, AB (Canada); Weir, D. [Enbridge Pipelines Inc., Calgary, AB (Canada)] (comps.)

    2009-07-01

    Risk assessments and risk analysis are system-wide activities that include site-specific risk and reliability-based decision-making, implementation, and monitoring. This working group discussed the risk management process in the pipeline industry, including reliability-based integrity management and risk control processes. Attendants at the group discussed reliability-based decision support and performance measurements designed to support corporate risk management policies. New developments and technologies designed to optimize risk management procedures were also presented. The group was divided into 3 sessions: (1) current practice, strengths and limitations of system-wide risk assessments for facility assets; (2) accounting for uncertainties to assure safety; and (3) reliability based excavation repair criteria and removing potentially unsafe corrosion defects. Presentations of risk assessment procedures used at various companies were given. The role of regulators, best practices, and effective networking environments in ensuring the success of risk assessment policies was discussed. Risk assessment models were also reviewed.

  4. Health Risk Assessment for Inhalation Exposure to Methyl Tertiary Butyl Ether at Petrol Stations in Southern China.

    Science.gov (United States)

    Hu, Dalin; Yang, Jianping; Liu, Yungang; Zhang, Wenjuan; Peng, Xiaowu; Wei, Qinzhi; Yuan, Jianhui; Zhu, Zhiliang

    2016-02-06

    Methyl tertiary butyl ether (MTBE), a well known gasoline additive, is used in China nationwide to enhance the octane number of gasoline and reduce harmful exhaust emissions, yet little is known regarding the potential health risk associated with occupational exposure to MTBE in petrol stations. In this study, 97 petrol station attendants (PSAs) in southern China were recruited for an assessment of the health risk associated with inhalation exposure to MTBE. The personal exposure levels of MTBE were analyzed by Head Space Solid Phase Microextraction GC/MS, and the demographic characteristics of the PSAs were investigated. Cancer and non-cancer risks were calculated with the methods recommended by the United States Environmental Protection Agency. The results showed that the exposure levels of MTBE in operating workers were much higher than among support staff (p operating workers, and 0.026 to 0.049 per 10⁶ for support staff, which are below the typical target range for risk management of 1 × 10(-6) to 1 × 10(-4); The hazard quotients (HQs) for all subjects were exposure of PSAs in southern China is in a low range which does not seem to be a significant health risk.

  5. The Distribution and Health Risk Assessment of Metals in Soils in the Vicinity of Industrial Sites in Dongguan, China

    Science.gov (United States)

    Liu, Chao; Lu, Liwen; Huang, Ting; Huang, Yalin; Ding, Lei; Zhao, Weituo

    2016-01-01

    Exponential industrialization and rapid urbanization have resulted in contamination of soil by metals from anthropogenic sources in Dongguan, China. The aims of this research were to determine the concentration and distribution of various metals (arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), nickel (Ni), lead (Pb) and zinc (Zn)) in soils and identify their potential health risks for local residents. A total of 106 soil samples were collected from the vicinity of industrial sites in Dongguan. Two types of samples were collected from each site: topsoil (0–20 cm, TS) and shallow soil (20–50 cm, SS). Results showed that the soils were contaminated by metals and pollution was mainly focused on TS. The geoaccumulation index (Igeo) and pollution indexes (PI) implied that there was a slight increase in the concentrations of Cd, Cu, Hg, Ni, and Pb, but the metal pollution caused by industrial activities was less severe, and elements of As and Cr exhibited non-pollution level. The risk assessment results suggested that there was a potential health risk associated with As and Cr exposure for residents because the carcinogenic risks of As and Cr via corresponding exposure pathways exceeded the safety limit of 10−6 (the acceptable level of carcinogenic risk for humans). Furthermore, oral ingestion and inhalation of soil particles are the main exposure pathways for As and Cr to enter the human body. This study may provide basic information of metal pollution control and human health protection in the vicinity of industrial regions. PMID:27548198

  6. Implications of global climate change for the assessment and management of human health risks of chemicals in the natural environment.

    Science.gov (United States)

    Balbus, John M; Boxall, Alistair B A; Fenske, Richard A; McKone, Thomas E; Zeise, Lauren

    2013-01-01

    Global climate change (GCC) is likely to alter the degree of human exposure to pollutants and the response of human populations to these exposures, meaning that risks of pollutants could change in the future. The present study, therefore, explores how GCC might affect the different steps in the pathway from a chemical source in the environment through to impacts on human health and evaluates the implications for existing risk-assessment and management practices. In certain parts of the world, GCC is predicted to increase the level of exposure of many environmental pollutants due to direct and indirect effects on the use patterns and transport and fate of chemicals. Changes in human behavior will also affect how humans come into contact with contaminated air, water, and food. Dietary changes, psychosocial stress, and coexposure to stressors such as high temperatures are likely to increase the vulnerability of humans to chemicals. These changes are likely to have significant implications for current practices for chemical assessment. Assumptions used in current exposure-assessment models may no longer apply, and existing monitoring methods may not be robust enough to detect adverse episodic changes in exposures. Organizations responsible for the assessment and management of health risks of chemicals therefore need to be more proactive and consider the implications of GCC for their procedures and processes.

  7. Quantitative health risk assessment of Cryptosporidium in rivers of southern China based on continuous monitoring.

    Science.gov (United States)

    An, Wei; Zhang, Dongqing; Xiao, Shumin; Yu, Jianwei; Yang, Min

    2011-06-01

    The concentrations of Cryptosporidium in the source water of several cities of Zhejiang Province, China were determined to be in the range of 0-17 oocysts/10 L in the rainy season in 2008, with a mean value of 7 oocysts/10 L. Based on the investigation data, comprehensive risk assessment of Cryptosporidium infection was performed by considering different water intake routes as well as water consumption. Intakes of unboiled tapwater (including drinking and tooth-brushing and food and dish washing) and source water (through swimming in rivers) were estimated to be 2.59-25.9 and 0.32-0.74 L/year-person, respectively. The mortality due to Cryptosporidium infection for people in this region, excluding HIV-infected patients, was calculated as 0-0.0146 per 10(5) persons using a conditional probability formula. Disability-adjusted life years (DALYs) were used to quantify the risk of Cryptosporidium infection, for which uncertainty was analyzed. For people who consumed conventionally treated water, the DALYs due to Cryptosporidium infection were 6.51 per 10(5) (95% CI: 2.16 × 10(-5)-22.35 × 10(-5)) persons, which were higher than a risk judged acceptable by some (1.97 × 10(-5) DALYs per year), and the risk for those consuming ozone-treated water became 0.0689 × 10(-5) DALYs per year. The major risk of infection resulted from swimming in the river. This study provides a method to establish the risk of Cryptosporidium infection and optimize the scheme for reducing the risk effectively, which is useful for the modification of water quality standards based on cost utility analysis given use of DALYs.

  8. Health-safety and environmental risk assessment of power plants using multi criteria decision making method

    Directory of Open Access Journals (Sweden)

    Jozi Ali Seyed

    2011-01-01

    Full Text Available Growing importance of environmental issues at global and regional levels including pollution of water, air etc. as well as the outcomes such as global warming and climate change has led to being considered environmental aspects as effective factors for power generation. Study ahead, aims at examination of risks resulting from activities of Yazd Combined Cycle Power Plant located in Iran. Method applied in the research is analytical hierarchy process. After identification of factors causing risk, the analytical hierarchy structure of the power plant risks were designed and weight of the criteria and sub-criteria were calculated by intensity probability product using Eigenvector Method and EXPERT CHOICE Software as well. Results indicate that in technological, health-safety, biophysical and socio economic sections of the power plant, factors influenced by the power plant activities like fire and explosion, hearing loss, quantity of groundwater, power generation are among the most important factors causing risk in the power plant. The drop in underground water levels is the most important natural consequence influenced on Yazd Combined Cycle Power Plant.

  9. Advice of the Italian CCTN on the health risk assessment relative to exposure to automobile emissions

    Energy Technology Data Exchange (ETDEWEB)

    Camoni, I. [ed.] [Istituto Superiore di Sanita`, Rome (Italy). Lab. di Tossicologia Applicata; Mucci, N. [ed.] [ISPESL, Monteporzio Catone, Roma (Italy). Dip. di Medicina del Lavoro; Foa`, V. [ed.] [Milan Univ. (Italy). Clinica del lavoro Luigi Devoto

    1998-06-01

    The period 1990-1995 are reported, they concern the health impact of exposure to benzene and polycyclic aromatic hydrocarbons (PAHs), resulting from automobile exhaust products, for Italian general and occupationally exposed populations. The first recommendation takes into consideration the possible long-term effects of the unleaded gasoline, recently introduced in Italy. The latter two recommendations concern the quantitative evaluation of the risk of leukaemia and of the risk of lung cancer from exposure to benzene and PAHs, resulting from automobile exhaust. [Italiano] Sono riportati i pareri espressi dalla Commissione Consultiva Tossicologica Nazionale (CCTN) nel periodo 1990-1995 riguardanti la valutazione del rischio cancerogeno per esposizione a sostanze contenute nelle emissioni autoveicolari. In particolare, viene stimato il rischio aggiuntivo di leucemia per esposizione a benzene e di cancro polmonare per esposizione a idrocarburi policiclici aromatici (IPA), sia per la popolazione generale che per quella professionalmente esposta.

  10. Environmental health-risk assessment for tritium releases at the National Tritium Labeling Facility at Lawrence Berkeley National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    McKone, T.E.; Brand, K.P. [Lawrence Livermore National Lab., CA (United States). Health and Ecological Assessment Div.; Shan, C. [Lawrence Berkeley National Lab., CA (United States). Earth Sciences Div.

    1997-04-01

    This risk assessment calculates the probability of experiencing health effects, including cancer incidence due to tritium exposure for three groups of people: (1) LBNL workers near the LBNL facility--Building 75--that uses tritium; (2) other workers at LBNL and nearby neighbors; and (3) people who use the UC Berkeley campus area, and some Berkeley residents. All of these groups share the same probability of health effects from the background radiation from natural sources in the Berkeley area environment, including an increased risk of developing a cancer of 11,000 chances per million. In calculating risk the authors assumed continuous operation in Building 75 for at least a human lifetime. Under this assumption, LBNL workers located near Building 75 have an additional risk of 60 chances out of one million to suffer a cancer; other workers at LBNL and people who live near LBNL have an additional risk of six chances out of one million over a lifetime of exposure; and users of the UC Berkeley campus area and other residents of Berkeley have an additional risk of less than once chance out of one million over a lifetime.

  11. Assessment of Ecological and Human Health Risks of Heavy Metal Contamination in Agriculture Soils Disturbed by Pipeline Construction

    Science.gov (United States)

    Shi, Peng; Xiao, Jun; Wang, Yafeng; Chen, Liding

    2014-01-01

    The construction of large-scale infrastructures such as nature gas/oil pipelines involves extensive disturbance to regional ecosystems. Few studies have documented the soil degradation and heavy metal contamination caused by pipeline construction. In this study, chromium (Cr), cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb) and zinc (Zn) levels were evaluated using Index of Geo-accumulation (Igeo) and Potential Ecological Risk Index (RI) values, and human health risk assessments were used to elucidate the level and spatial variation of heavy metal pollution risks. The results showed that the impact zone of pipeline installation on soil heavy metal contamination was restricted to pipeline right-of-way (RoW), which had higher Igeo of Cd, Cu, Ni and Pb than that of 20 m and 50 m. RI showed a declining tendency in different zones as follows: trench > working zone > piling area > 20 m > 50 m. Pipeline RoW resulted in higher human health risks than that of 20 m and 50 m, and children were more susceptible to non-carcinogenic hazard risk. Cluster analysis showed that Cu, Ni, Pb and Cd had similar sources, drawing attention to the anthropogenic activity. The findings in this study should help better understand the type, degree, scope and sources of heavy metal pollution from pipeline construction to reduce pollutant emissions, and are helpful in providing a scientific basis for future risk management. PMID:24590049

  12. Assessment of ecological and human health risks of heavy metal contamination in agriculture soils disturbed by pipeline construction.

    Science.gov (United States)

    Shi, Peng; Xiao, Jun; Wang, Yafeng; Chen, Liding

    2014-02-28

    The construction of large-scale infrastructures such as nature gas/oil pipelines involves extensive disturbance to regional ecosystems. Few studies have documented the soil degradation and heavy metal contamination caused by pipeline construction. In this study, chromium (Cr), cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb) and zinc (Zn) levels were evaluated using Index of Geo-accumulation (Igeo) and Potential Ecological Risk Index (RI) values, and human health risk assessments were used to elucidate the level and spatial variation of heavy metal pollution risks. The results showed that the impact zone of pipeline installation on soil heavy metal contamination was restricted to pipeline right-of-way (RoW), which had higher Igeo of Cd, Cu, Ni and Pb than that of 20 m and 50 m. RI showed a declining tendency in different zones as follows: trench > working zone > piling area > 20 m > 50 m. Pipeline RoW resulted in higher human health risks than that of 20 m and 50 m, and children were more susceptible to non-carcinogenic hazard risk. Cluster analysis showed that Cu, Ni, Pb and Cd had similar sources, drawing attention to the anthropogenic activity. The findings in this study should help better understand the type, degree, scope and sources of heavy metal pollution from pipeline construction to reduce pollutant emissions, and are helpful in providing a scientific basis for future risk management.

  13. Assessment of Ecological and Human Health Risks of Heavy Metal Contamination in Agriculture Soils Disturbed by Pipeline Construction

    Directory of Open Access Journals (Sweden)

    Peng Shi

    2014-02-01

    Full Text Available The construction of large-scale infrastructures such as nature gas/oil pipelines involves extensive disturbance to regional ecosystems. Few studies have documented the soil degradation and heavy metal contamination caused by pipeline construction. In this study, chromium (Cr, cadmium (Cd, copper (Cu, nickel (Ni, lead (Pb and zinc (Zn levels were evaluated using Index of Geo-accumulation (Igeo and Potential Ecological Risk Index (RI values, and human health risk assessments were used to elucidate the level and spatial variation of heavy metal pollution risks. The results showed that the impact zone of pipeline installation on soil heavy metal contamination was restricted to pipeline right-of-way (RoW, which had higher Igeo of Cd, Cu, Ni and Pb than that of 20 m and 50 m. RI showed a declining tendency in different zones as follows: trench > working zone > piling area > 20 m > 50 m. Pipeline RoW resulted in higher human health risks than that of 20 m and 50 m, and children were more susceptible to non-carcinogenic hazard risk. Cluster analysis showed that Cu, Ni, Pb and Cd had similar sources, drawing attention to the anthropogenic activity. The findings in this study should help better understand the type, degree, scope and sources of heavy metal pollution from pipeline construction to reduce pollutant emissions, and are helpful in providing a scientific basis for future risk management.

  14. A comprehensive assessment of arsenic in commonly consumed foodstuffs to evaluate the potential health risk in Bangladesh

    Energy Technology Data Exchange (ETDEWEB)

    Ahmed, Md. Kawser [Faculty of Earth & Environmental Sciences, University of Dhaka, Dhaka 1000 (Bangladesh); Shaheen, Nazma [Institute of Nutrition and Food Science (INFS), University of Dhaka, Dhaka 1000 (Bangladesh); Islam, Md. Saiful [Department of Risk Management and Environmental Sciences, Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama, Kanagawa 240-8501 (Japan); Habibullah-Al-Mamun, Md., E-mail: habibullah-al-sj@ynu.jp [Department of Risk Management and Environmental Sciences, Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama, Kanagawa 240-8501 (Japan); Department of Fisheries, University of Dhaka, Dhaka 1000 (Bangladesh); Islam, Saiful [Institute of Nutrition and Food Science (INFS), University of Dhaka, Dhaka 1000 (Bangladesh); Islam, Md. Monirul [Department of Fisheries, University of Dhaka, Dhaka 1000 (Bangladesh); School of Earth and Environment, Leeds University, Leeds LS2, 9JT (United Kingdom); Kundu, Goutam Kumar [Department of Fisheries, University of Dhaka, Dhaka 1000 (Bangladesh); Bhattacharjee, Lalita [National Food Policy Capacity Strengthening Programme, Food and Agriculture Organization of the United Nations (Bangladesh)

    2016-02-15

    Arsenic (As), particularly of its inorganic form (iAs) is highly toxic, and its presence in food composites is a matter of concern for the public health safety, specifically in Bangladesh which is regarded as the most arsenic affected country throughout the world. This study was carried out to investigate the levels of As in the composite samples of commonly consumed foodstuffs collected from 30 different agro-ecological zones for the first time in Bangladesh. Most of the individual food composites contain a considerable amount of As which was, as a whole, in the range of 0.077–1.5 mg/kg fw which was lower than those reported from Spain, EU, France, Korea, whereas higher than those of Mexico, Chile, Japan, Cambodia, Hong Kong, Serbia, respectively. Cereals, vegetables, milk, and fish contribute about 90% to the daily intake of inorganic arsenic. Human health risk of dietary iAs was assessed separately for both the rural and urban adults. The estimated daily dietary intakes (EDI) of iAs for the exposed rural (3.5) and urban residents (3.2 μg/kg-BW/day) clearly exceeded the previous provisional tolerable daily intake (PTDI) value of 2.1 μg/kg-BW/day, recommended by the World Health Organization (WHO). From the health point of view, this study concluded that both the rural and urban residents of Bangladesh are exposed to carcinogenic and non-carcinogenic risks who consume As-contaminated water and foodstuffs. - Highlights: • A comprehensive health risk assessment from dietary arsenic exposure was evaluated. • Sample collected from 30 agro-ecological zones for the first time in Bangladesh. • Rural and urban adults are consuming more arsenic through food than the safe limit. • Cereals, vegetables, milk, and fish contribute about 90% to EDI of inorganic As. • Inhabitants are exposed chronically to arsenic induced risks.

  15. Analysis of indoor air pollutants checklist using environmetric technique for health risk assessment of sick building complaint in nonindustrial workplace

    Science.gov (United States)

    Syazwan, AI; Rafee, B Mohd; Juahir, Hafizan; Azman, AZF; Nizar, AM; Izwyn, Z; Syahidatussyakirah, K; Muhaimin, AA; Yunos, MA Syafiq; Anita, AR; Hanafiah, J Muhamad; Shaharuddin, MS; Ibthisham, A Mohd; Hasmadi, I Mohd; Azhar, MN Mohamad; Azizan, HS; Zulfadhli, I; Othman, J; Rozalini, M; Kamarul, FT

    2012-01-01

    Purpose To analyze and characterize a multidisciplinary, integrated indoor air quality checklist for evaluating the health risk of building occupants in a nonindustrial workplace setting. Design A cross-sectional study based on a participatory occupational health program conducted by the National Institute of Occupational Safety and Health (Malaysia) and Universiti Putra Malaysia. Method A modified version of the indoor environmental checklist published by the Department of Occupational Health and Safety, based on the literature and discussion with occupational health and safety professionals, was used in the evaluation process. Summated scores were given according to the cluster analysis and principal component analysis in the characterization of risk. Environmetric techniques was used to classify the risk of variables in the checklist. Identification of the possible source of item pollutants was also evaluated from a semiquantitative approach. Result Hierarchical agglomerative cluster analysis resulted in the grouping of factorial components into three clusters (high complaint, moderate-high complaint, moderate complaint), which were further analyzed by discriminant analysis. From this, 15 major variables that influence indoor air quality were determined. Principal component analysis of each cluster revealed that the main factors influencing the high complaint group were fungal-related problems, chemical indoor dispersion, detergent, renovation, thermal comfort, and location of fresh air intake. The moderate-high complaint group showed significant high loading on ventilation, air filters, and smoking-related activities. The moderate complaint group showed high loading on dampness, odor, and thermal comfort. Conclusion This semiquantitative assessment, which graded risk from low to high based on the intensity of the problem, shows promising and reliable results. It should be used as an important tool in the preliminary assessment of indoor air quality and as a

  16. Information security governance: a risk assessment approach to health information systems protection.

    Science.gov (United States)

    Williams, Patricia A H

    2013-01-01

    It is no small task to manage the protection of healthcare data and healthcare information systems. In an environment that is demanding adaptation to change for all information collection, storage and retrieval systems, including those for of e-health and information systems, it is imperative that good information security governance is in place. This includes understanding and meeting legislative and regulatory requirements. This chapter provides three models to educate and guide organisations in this complex area, and to simplify the process of information security governance and ensure appropriate and effective measures are put in place. The approach is risk based, adapted and contextualized for healthcare. In addition, specific considerations of the impact of cloud services, secondary use of data, big data and mobile health are discussed.

  17. Health risks in perspective: Judging health risks of energy technologies

    Energy Technology Data Exchange (ETDEWEB)

    Rowe, M.D.

    1992-09-18

    Almost daily, Americans receive reports from the mass news media about some new and frightening risk to health and welfare. Most such reports emphasize the newsworthiness of the risks -- the possibility of a crisis, disagreements among experts, how things happened, who is responsible for fixing them, how much will it cost, conflict among parties involved, etc. As a rule, the magnitudes of the risks, or the difficulty of estimating those magnitudes, have limited newsworthiness, and so they are not mentioned. Because of this emphasis in the news media, most people outside the risk assessment community must judge the relative significance of the various risks to which we all are exposed with only that information deemed newsworthy by reporters. This information is biased and shows risks in isolation. There is no basis for understanding and comparing the relative importance of risks among themselves, or for comparing one risk, perhaps a new or newly-discovered one, in the field of all risks. The purpose of this report is to provide perspective on the various risks to which we are routinely exposed. It serves as a basis for understanding the meaning of quantitative risk estimates and for comparing new or newly-discovered risks with other, better-understood risks. Specific emphasis is placed on health risks of energy technologies.

  18. Arsenic exposure in Latin America: biomarkers, risk assessments and related health effects.

    Science.gov (United States)

    McClintock, Tyler R; Chen, Yu; Bundschuh, Jochen; Oliver, John T; Navoni, Julio; Olmos, Valentina; Lepori, Edda Villaamil; Ahsan, Habibul; Parvez, Faruque

    2012-07-01

    In Latin America, several regions have a long history of widespread arsenic (As) contamination from both natural and anthropological sources. Yet, relatively little is known about the extent of As exposure from drinking water and its related health consequences in these countries. It has been estimated that at least 4.5 million people in Latin America are chronically exposed to high levels of As (>50 μg/L), some to as high as 2000 μg/L--200 times higher than the World Health Organization (WHO) provisional standard for drinking water. We conducted a systematic review of 82 peer reviewed papers and reports to fully explore the current understanding of As exposure and its health effects, as well as the influence of genetic factors that modulate those effects in the populations of Latin America. Despite some methodological limitations, these studies suggested important links between the high levels of chronic As exposure and elevated risks of numerous adverse health outcomes in Latin America--including internal and external cancers, reproductive outcomes, and childhood cognitive function. Several studies demonstrated genetic polymorphisms that influence susceptibility to these and other disease states through their modulation of As metabolism, with As methyltransferase (AS3MT), glutathione S-transferase (GST), and genes of one-carbon metabolism being specifically implicated. While the full extent and nature of the health burden are yet to be known in Latin America, these studies have significantly enriched knowledge of As toxicity and led to subsequent research. Targeted future studies will not only yield a better understanding of the public health impact of As in Latin America populations, but also allow for effective and timely mitigation efforts.

  19. Potential molecular tools for assessing the public health risk associated with waterborne Cryptosporidium oocysts.

    Science.gov (United States)

    Kothavade, Rajendra J

    2012-08-01

    The use of multiple barrier stages at water and wastewater treatment facilities allows for the effective removal of the vast majority of coliforms and other enteric and non-enteric microbes. Subsequent disinfection steps (chlorine, ozone and UV irradiation) are utilized to inactivate microbes that escape the preceding treatment stages. Most viruses, bacteria and protozoa, such as Giardia, are effectively inactivated by chlorination; however, Cryptosporidium is relatively more resistant to environmental conditions and to chlorination. Therefore, UV disinfection has been introduced at many water and wastewater treatment plants to increase log inactivation. Any accidental treatment failure may pose a significant risk to public health. Waterborne transmission of coccidian parasites such as Cryptosporidium and Giardia continues to be a major public health concern. No effective therapies currently exist to treat cryptosporidiosis and the global increase in immunocompromised populations has emphasized the need for water utilities and public health laboratories to have immediate and reliable access to highly sensitive test methods that can determine the host specificity, viability and infectivity of protozoa in the water supply. The most common method used for monitoring Cryptosporidium oocysts and Giardia cysts at intermediate treatment stages and in finished drinking water is the US EPA Method 1623. Although Cryptosporidium species are morphologically indistinguishable, they differ greatly in their host specificity and infectivity. Method 1623 provides quantitative information about Cryptosporidium and Giardia contamination but cannot distinguish between species for intervention purposes in outbreak situations, nor is this method reliable for determining whether the oocyst on the slide is infective for humans. Molecular methods have proven valuable in diagnosing infectious diseases, especially those for which the causative agent is difficult to grow in culture, and

  20. Fine particulate matter in the tropical environment: monsoonal effects, source apportionment, and health risk assessment

    Science.gov (United States)

    Khan, M. F.; Latif, M. T.; Saw, W. H.; Amil, N.; Nadzir, M. S. M.; Sahani, M.; Tahir, N. M.; Chung, J. X.

    2016-01-01

    The health implications of PM2.5 in the tropical region of Southeast Asia (SEA) are significant as PM2.5 can pose serious health concerns. PM2.5 concentration and sources here are strongly influenced by changes in the monsoon regime from the south-west quadrant to the north-east quadrant in the region. In this work, PM2.5 samples were collected at a semi-urban area using a high-volume air sampler at different seasons on 24 h basis. Analysis of trace elements and water-soluble ions was performed using inductively coupled plasma mass spectroscopy (ICP-MS) and ion chromatography (IC), respectively. Apportionment analysis of PM2.5 was carried out using the United States Environmental Protection Agency (US EPA) positive matrix factorization (PMF) 5.0 and a mass closure model. We quantitatively characterized the health risks posed to human populations through the inhalation of selected heavy metals in PM2.5. 48 % of the samples collected exceeded the World Health Organization (WHO) 24 h PM2.5 guideline but only 19 % of the samples exceeded 24 h US EPA National Ambient Air Quality Standard (NAAQS). The PM2.5 concentration was slightly higher during the north-east monsoon compared to south-west monsoon. The main trace metals identified were As, Pb, Cd, Ni, Mn, V, and Cr while the main ions were SO42-, NO3-, NH4+, and Na. The mass closure model identified four major sources of PM2.5 that account for 55 % of total mass balance. The four sources are mineral matter (MIN) (35 %), secondary inorganic aerosol (SIA) (11 %), sea salt (SS) (7 %), and trace elements (TE) (2 %). PMF 5.0 elucidated five potential sources: motor vehicle emissions coupled with biomass burning (31 %) were the most dominant, followed by marine/sulfate aerosol (20 %), coal burning (19 %), nitrate aerosol (17 %), and mineral/road dust (13 %). The hazard quotient (HQ) for four selected metals (Pb, As, Cd, and Ni) in PM2.5 mass was highest in PM2.5 mass from the coal burning source and least in PM2.5 mass

  1. Predicting suicides after outpatient mental health visits in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)

    Science.gov (United States)

    Kessler, Ronald C.; Stein, Murray B.; Petukhova, Maria V.; Bliese, Paul; Bossarte, Robert M.; Bromet, Evelyn J.; Fullerton, Carol S.; Gilman, Stephen E.; Ivany, Christopher; Lewandowski-Romps, Lisa; Bell, Amy Millikan; Naifeh, James A.; Nock, Matthew K.; Reis, Benjamin Y.; Rosellini, Anthony J.; Sampson, Nancy A.; Zaslavsky, Alan M.; Ursano, Robert J.

    2016-01-01

    The 2013 U.S. Veterans Administration/Department of Defense Clinical Practice Guidelines (VA/DoD CPG) require comprehensive suicide risk assessments for VA/DoD patients with mental disorders but provide minimal guidance on how to carry out these assessments. Given that clinician-based assessments are known not to be strong predictors of suicide, we investigated whether a precision medicine model using administrative data after outpatient mental health specialty visits could be developed to predict suicides among outpatients. We focused on male non-deployed Regular U.S. Army soldiers because they account for the vast majority of such suicides. Four machine learning classifiers (naïve Bayes, random forests, support vector regression, elastic net penalized regression) were explored. 41.5% of Army suicides in 2004-2009 occurred among the 12.0% of soldiers seen as outpatient by mental health specialists, with risk especially high within 26 weeks of visits. An elastic net classifier with 10-14 predictors optimized sensitivity (45.6% of suicide deaths occurring after the 15% of visits with highest predicted risk). Good model stability was found for a model using 2004-2007 data to predict 2008-2009 suicides, although stability decreased in a model using 2008-2009 data to predict 2010-2012 suicides. The 5% of visits with highest risk included only 0.1% of soldiers (1047.1 suicides/100,000 person-years in the 5 weeks after the visit). This is a high enough concentration of risk to have implications for targeting preventive interventions. An even better model might be developed in the future by including the enriched information on clinician-evaluated suicide risk mandated by the VA/DoD CPG to be recorded. PMID:27431294

  2. Polycyclic aromatic hydrocarbons (PAHs) in multimedia environment of Heshan coal district, Guangxi: distribution, source diagnosis and health risk assessment.

    Science.gov (United States)

    Huang, Huan-Fang; Xing, Xin-Li; Zhang, Ze-Zhou; Qi, Shi-Hua; Yang, Dan; Yuen, Dave A; Sandy, Edward H; Zhou, Ai-Guo; Li, Xiao-Qian

    2016-10-01

    Mining activities are among the major culprits of the wide occurrences of soil and water pollution by PAHs in coal district, which have resulted in ecological fragilities and health risk for local residents. Sixteen PAHs in multimedia environment from the Heshan coal district of Guangxi, South China, were measured, aiming to investigate the contamination level, distribution and possible sources and to estimate the potential health risks of PAHs. The average concentrations of 16 PAHs in the coal, coal gangue, soil, surface water and groundwater were 5114.56, 4551.10, 1280.12 ng g(-1), 426.98 and 381.20 ng L(-1), respectively. Additionally, higher soil and water PAH concentrations were detected in the vicinities of coal or coal gangue dump. Composition analysis, isomeric ratio, Pearson correlation analysis and principal component analysis were performed to diagnose the potential sources of PAHs in different environmental matrices, suggesting the dominant inputs of PAHs from coal/coal combustion and coal gangue in the soil and water. Soil and water guidelines and the incremental lifetime risk (ICLR) were used to assess the health risk, showing that soil and water were heavily contaminated by PAHs, and mean ICLRcoal/coal-gangue and mean ICLRsoil were both significantly higher than the acceptable levels (1 × 10(-4)), posing high potential carcinogenic risk to residents, especially coal workers. This study highlights the environmental pollution problems and public health concerns of coal mining, particularly the potential occupational health hazards of coal miners exposed in Heshan.

  3. Health risk assessment of heavy metals in soil-plant system amended with biogas slurry in Taihu basin, China.

    Science.gov (United States)

    Bian, Bo; Lin, Cheng; Lv, Lin

    2016-09-01

    Biogas slurry is a product of anaerobic digestion of manure that has been widely used as a soil fertilizer. Although the use for soil fertilizer is a cost-effective solution, it has been found that repeated use of biogas slurry that contains high heavy metal contents can cause pollution to the soil-plant system and risk to human health. The objective of this study was to investigate effects of biogas slurry on the soil-plant system and the human health. We analyzed the heavy metal concentrations (including As, Pb, Cu, Zn, Cr and Cd) in 106 soil samples and 58 plant samples in a farmland amended with biogas slurry in Taihu basin, China. Based on the test results, we assessed the potential human health risk when biogas slurry containing heavy metals was used as a soil fertilizer. The test results indicated that the Cd and Pb concentrations in soils exceeded the contamination limits and Cd exhibited the highest soil-to-root migration potential. Among the 11 plants analyzed, Kalimeris indica had the highest heavy metal absorption capacity. The leafy vegetables showed higher uptake of heavy metals than non-leafy vegetables. The non-carcinogenic risks mainly resulted from As, Pb, Cd, Cu and Zn through plant ingestion exposure. The integrated carcinogenic risks were associated with Cr, As and Cd in which Cr showed the highest risk while Cd showed the lowest risk. Among all the heavy metals analyzed, As and Cd appeared to have a lifetime health threat, which thus should be attenuated during production of biogas slurry to mitigate the heavy metal contamination.

  4. Including the urban heat island in spatial heat health risk assessment strategies: a case study for Birmingham, UK

    Directory of Open Access Journals (Sweden)

    Thornes John E

    2011-06-01

    Full Text Available Abstract Background Heatwaves present a significant health risk and the hazard is likely to escalate with the increased future temperatures presently predicted by climate change models. The impact of heatwaves is often felt strongest in towns and cities where populations are concentrated and where the climate is often unintentionally modified to produce an urban heat island effect; where urban areas can be significantly warmer than surrounding rural areas. The purpose of this interdisciplinary study is to integrate remotely sensed urban heat island data alongside commercial social segmentation data via a spatial risk assessment methodology in order to highlight potential heat health risk areas and build the foundations for a climate change risk assessment. This paper uses the city of Birmingham, UK as a case study area. Results When looking at vulnerable sections of the population, the analysis identifies a concentration of "very high" risk areas within the city centre, and a number of pockets of "high risk" areas scattered throughout the conurbation. Further analysis looks at household level data which yields a complicated picture with a considerable range of vulnerabilities at a neighbourhood scale. Conclusions The results illustrate that a concentration of "very high" risk people live within the urban heat island, and this should be taken into account by urban planners and city centre environmental managers when considering climate change adaptation strategies or heatwave alert schemes. The methodology has been designed to be transparent and to make use of powerful and readily available datasets so that it can be easily replicated in other urban areas.

  5. Quantitative analysis and health risk assessment of polycyclic aromatic hydrocarbons in edible vegetable oils marketed in Shandong of China.

    Science.gov (United States)

    Jiang, Dafeng; Xin, Chenglong; Li, Wei; Chen, Jindong; Li, Fenghua; Chu, Zunhua; Xiao, Peirui; Shao, Lijun

    2015-09-01

    This work studies on the quantitative analysis and health risk assessment of polycyclic aromatic hydrocarbons (PAHs) in edible vegetable oils in Shandong, China. The concentrations of 15 PAHs in 242 samples were determined by high performance liquid chromatography coupled with fluorescence detection. The results indicated that the mean concentration of 15 PAHs in oil samples was 54.37 μg kg(-1). Low molecular weight PAH compounds were the predominant contamination. Especially, the carcinogenic benzo(a)pyrene (BaP) was detected at a mean concentration of 1.28 μg kg(-1), which was lower than the limit of European Union and China. A preliminary evaluation of human health risk assessment for PAHs was accomplished using BaP toxic equivalency factors and the incremental lifetime cancer risk (ILCR). The ILCR values for children, adolescents, adults, and seniors were all larger than 1 × 10(-6), indicating a high potential carcinogenic risk on the dietary exposed populations.

  6. Source identification and health risk assessment of metals in indoor dust in the vicinity of phosphorus mining, Guizhou Province, China.

    Science.gov (United States)

    Yang, Qin; Chen, Huaguo; Li, Baizhan

    2015-01-01

    An investigation was performed to identify the sources of arsenic (As) and heavy metals in house dust and to assess the associated human health risks in the vicinity of phosphorus (P) mining in Guizhou, China. The concentrations and spatial distributions of mercury (Hg), As, cadmium (Cd), lead (Pb), iron (Fe), copper (Cu), manganese (Mn), and P in 23 house dust samples from the study area were determined. Greater concentrations of As and Pb were found compared with values in other investigations in various countries. Pollution sources were identified using multivariate statistical analysis. As, Pb, Mn, and Hg pollution was mainly attributed to mining activities, and Mn and Cd levels were largely associated with automobile emissions. The dominant wind direction and the distance of the residence from the mining region were found to play an important role in element distributions. A health risk assessment showed that As and Pb should be paid more attention, although the noncancer risks of the studied elements were within the safe range and the cancer risks of As and Cd are within the acceptable range under present conditions.

  7. Assessment of Health Risk from Historical Use of Cosmetic Talcum Powder.

    Science.gov (United States)

    Anderson, Elizabeth L; Sheehan, Patrick J; Kalmes, Renee M; Griffin, John R

    2016-07-09

    This study's objective is to assess the risk of asbestos-related disease being contracted by past users of cosmetic talcum powder.  To our knowledge, no risk assessment studies using exposure data from historical exposures or chamber simulations have been published. We conducted activity-based sampling with cosmetic talcum powder samples from five opened and previously used containers that are believed to have been first manufactured and sold in the 1960s and 1970s.  These samples had been subject to conflicting claims of asbestos content; samples with the highest claimed asbestos content were tested.  The tests were conducted in simulated-bathroom controlled chambers with volunteers who were talc users.  Air sampling filters were prepared by direct preparation techniques and analyzed by phase contrast microscopy (PCM), transmission electron microscopy (TEM) with energy-dispersive x-ray (EDX) spectra, and selective area diffraction (SAED).  TEM analysis for asbestos resulted in no confirmed asbestos fibers and only a single fiber classified as "ambiguous."  Hypothetical treatment of this fiber as if it were asbestos yields a risk of 9.6 × 10(-7) (under one in one million) for a lifetime user of this cosmetic talcum powder.  The exposure levels associated with these results range from zero to levels far below those identified in the epidemiology literature as posing a risk for asbestos-related disease, and substantially below published historical environmental background levels.  The approaches used for this study have potential application to exposure evaluations of other talc or asbestos-containing materials and consumer products.

  8. Health risk assessment of dioxin exposure in the City of Menen (Belgium)

    Energy Technology Data Exchange (ETDEWEB)

    Nouwen, J.; Provoost, J.; Cornelis, C.; Bronders, J. [Flemish Inst. for Tech. Research (VITO) (Belgium)

    2004-09-15

    The City of Menen is a well-outlined residential area located in the neighbourhood of two waste incinerators. The waste incinerators (Menen (Belgium) and Roncq (France)) were in full operation since the eighties. Both waste incinerators are still operational and emission measurements indicate that they fulfil the European Union dioxin emission standard of 0.1 ng TEQ/m{sup 3}. Despite of this, new deposition measurements and analysis of milk in this region indicate a high burdening of the local environment with dioxin-like polychlorinated biphenyls (dioxin-like PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). It should be noted that formerly the City of Menen was also surrounded by other potential dioxin sources, among them a dye factory, some small illegal cable burning houses, a pressed board manufacturer, and a metal recycling plant. In the past, before 1984, fly ashes of the waste incinerator were locally valorized as road materials and transported. This could be a secondary source. Additionally the Environmental Inspection has regularly noticed some large open wastefires in this region and follows up the situation. On request of the Public Waste Agency of Flanders (OVAM) an inventory of all measurements in this area was made. An additional sampling of soil, vegetables and eggs was carried out in order to achieve an optimal human risk assessment for the City of Menen. At first instance this risk assessment was carried out by using a deterministic approach. The used human exposure model calculates point estimates based on a combination of unique parameter values. This, however, gives no indication of the variation of the model output. The value of a model parameter is chosen such that a conservative point estimate is obtained for the risk index. Due to variation, it is often unclear how conservative this estimate really is. Hence the variation of the calculated risk index is not known. The calculations of the risk index are subjected to

  9. Integrated modelling for assessing the risk of groundwater contaminants to human health and surface water ecosystems

    DEFF Research Database (Denmark)

    McKnight, Ursula S.; Rasmussen, Jes; Funder, Simon G.

    2010-01-01

    of contamination. In particular, adaptive management tools designed to work with sparse data sets from preliminary site assessments are needed which can explicitly link contaminant point sources with groundwater, surface water and ecological impacts. Here, a novel integrated modelling approach was employed......The practical implementation of the European Water Framework Directive has resulted in an increased focus on the groundwater-surface water interaction zone. A gap exists with respect to preliminary assessment methodologies that are capable of evaluating and prioritising point sources...... volatilisation model for the stream. The model is tested on a Danish case study involving a 750 m long TCE groundwater plume discharging into a stream. The initial modelling results indicate that TCE contaminant plumes with μgL-1 concentrations entering surface water systems do not pose a significant risk...

  10. Endocrine disruptor phthalates in bottled water: daily exposure and health risk assessment in pregnant and lactating women.

    Science.gov (United States)

    Jeddi, Maryam Zare; Rastkari, Noushin; Ahmadkhaniha, Reza; Yunesian, Masud

    2016-09-01

    Over the last decade, the consumption of water bottled in polyethylene terephthalate (PET) has considerably increased, raising concerns over water quality and packaged materials. This study aims to investigate the levels of the anti-androgenic phthalates including bis-(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and benzyl butyl phthalate (BBP), in bottled water and its corresponding health risks in pregnant and lactating women. The phthalate levels were measured in six different brands of bottled water exposed to temperatures ranging between -18 and 40 °C and sunlight for 45 days. The phthalate was quantified using the gas chromatography-mass spectrometry (GC-MS). In addition, the non-carcinogenic effects were assessed using hazard quotient (HQ) approach, and cumulative health risk assessment was performed on the basis of hazard index (HI) calculation. In order to assess the carcinogenic risk due to the possible carcinogen DEHP (group 2B), the excess lifetime cancer risk (ELCR) was used. DEHP and DBP contaminants were detected at different storage conditions in all of the bottled water samples during the storage time. BBP was only detected at high temperature (≥25 °C) and outdoor conditions. The maximum concentrations of all phthalates were observed when water samples were kept at 40 °C. In contrast, storage at freezing conditions had no significant effect on the concentration level of all phthalates. The estimated intake by women was between 0.0021 μg/kg/day for BBP and 0.07 μg/kg/day for DEHP. The highest HQ for phthalate intake via bottled water consumption was much lower than 1 (HQ bottled water are not a health concern for pregnant and lactating women. Consequently, PET-bottled water is not a major contributor to phthalate intake for most individuals.

  11. Cloud-Based Smart Health Monitoring System for Automatic Cardiovascular and Fall Risk Assessment in Hypertensive Patients.

    Science.gov (United States)

    Melillo, P; Orrico, A; Scala, P; Crispino, F; Pecchia, L

    2015-10-01

    The aim of this paper is to describe the design and the preliminary validation of a platform developed to collect and automatically analyze biomedical signals for risk assessment of vascular events and falls in hypertensive patients. This m-health platform, based on cloud computing, was designed to be flexible, extensible, and transparent, and to provide proactive remote monitoring via data-mining functionalities. A retrospective study was conducted to train and test the platform. The developed system was able to predict a future vascular event within the next 12 months with an accuracy rate of 84 % and to identify fallers with an accuracy rate of 72 %. In an ongoing prospective trial, almost all the recruited patients accepted favorably the system with a limited rate of inadherences causing data losses (<20 %). The developed platform supported clinical decision by processing tele-monitored data and providing quick and accurate risk assessment of vascular events and falls.

  12. Assessment of cardiovascular risk.

    LENUS (Irish Health Repository)

    Cooney, Marie Therese

    2010-10-01

    Atherosclerotic cardiovascular disease (CVD) is the most common cause of death worldwide. Usually atherosclerosis is caused by the combined effects of multiple risk factors. For this reason, most guidelines on the prevention of CVD stress the assessment of total CVD risk. The most intensive risk factor modification can then be directed towards the individuals who will derive the greatest benefit. To assist the clinician in calculating the effects of these multiple interacting risk factors, a number of risk estimation systems have been developed. This review address several issues regarding total CVD risk assessment: Why should total CVD risk be assessed? What risk estimation systems are available? How well do these systems estimate risk? What are the advantages and disadvantages of the current systems? What are the current limitations of risk estimation systems and how can they be resolved? What new developments have occurred in CVD risk estimation?

  13. Development and Psychometric Assessment of the Measure of Globalization Influence on Health Risk (MGIHR) Among Mexican Women with Breast Cancer.

    Science.gov (United States)

    Nodora, Jesse N; Carvajal, Scott C; Robles-Garcia, Rebeca; Agraz, Francisco Páez; Daneri-Navarro, Adrian; Meza-Montenegro, Maria Mercedes; Gutierrez-Millan, Luis Enrique; Martinez, Maria Elena

    2015-08-01

    Lacking in the literature are data addressing the extent to which changes in reproductive and lifestyle factors predispose women in developing nations to higher breast cancer rates, and the degree to which these are due to globalization influences. This article describes the development and psychometric assessment of an instrument intended to measure global, predominantly U.S., influences on breast cancer risk profile among women residing in Mexico. Using investigator consensus and a focus group methodology, the Measure of Globalization Influence on Health Risk (MGIHR) was developed and completed by 341 women. Psychometric analysis support the use of an 11-item Consumerism and Modernity scale and 7-item Reproductive Control and Gender Role scale. The MGIHR is a valid and reliable instrument for understanding changing lifestyle and reproductive factors for breast cancer risk and may provide a more complete understanding of breast cancer development and needed interventions.

  14. Wildlife Trade and Human Health in Lao PDR: An Assessment of the Zoonotic Disease Risk in Markets.

    Directory of Open Access Journals (Sweden)

    Zoe F Greatorex

    Full Text Available Although the majority of emerging infectious diseases can be linked to wildlife sources, most pathogen spillover events to people could likely be avoided if transmission was better understood and practices adjusted to mitigate risk. Wildlife trade can facilitate zoonotic disease transmission and represents a threat to human health and economies in Asia, highlighted by the 2003 SARS coronavirus outbreak, where a Chinese wildlife market facilitated pathogen transmission. Additionally, wildlife trade poses a serious threat to biodiversity. Therefore, the combined impacts of Asian wildlife trade, sometimes termed bush meat trade, on public health and biodiversity need assessing. From 2010 to 2013, observational data were collected in Lao PDR from markets selling wildlife, including information on volume, form, species and price of wildlife; market biosafety and visitor origin. The potential for traded wildlife to host zoonotic diseases that pose a serious threat to human health was then evaluated at seven markets identified as having high volumes of trade. At the seven markets, during 21 observational surveys, 1,937 alive or fresh dead mammals (approximately 1,009 kg were observed for sale, including mammals from 12 taxonomic families previously documented to be capable of hosting 36 zoonotic pathogens. In these seven markets, the combination of high wildlife volumes, high risk taxa for zoonoses and poor biosafety increases the potential for pathogen presence and transmission. To examine the potential conservation impact of trade in markets, we assessed the status of 33,752 animals observed during 375 visits to 93 markets, under the Lao PDR Wildlife and Aquatic Law. We observed 6,452 animals listed by Lao PDR as near extinct or threatened with extinction. The combined risks of wildlife trade in Lao PDR to human health and biodiversity highlight the need for a multi-sector approach to effectively protect public health, economic interests and

  15. Wildlife Trade and Human Health in Lao PDR: An Assessment of the Zoonotic Disease Risk in Markets.

    Science.gov (United States)

    Greatorex, Zoe F; Olson, Sarah H; Singhalath, Sinpakone; Silithammavong, Soubanh; Khammavong, Kongsy; Fine, Amanda E; Weisman, Wendy; Douangngeun, Bounlom; Theppangna, Watthana; Keatts, Lucy; Gilbert, Martin; Karesh, William B; Hansel, Troy; Zimicki, Susan; O'Rourke, Kathleen; Joly, Damien O; Mazet, Jonna A K

    2016-01-01

    Although the majority of emerging infectious diseases can be linked to wildlife sources, most pathogen spillover events to people could likely be avoided if transmission was better understood and practices adjusted to mitigate risk. Wildlife trade can facilitate zoonotic disease transmission and represents a threat to human health and economies in Asia, highlighted by the 2003 SARS coronavirus outbreak, where a Chinese wildlife market facilitated pathogen transmission. Additionally, wildlife trade poses a serious threat to biodiversity. Therefore, the combined impacts of Asian wildlife trade, sometimes termed bush meat trade, on public health and biodiversity need assessing. From 2010 to 2013, observational data were collected in Lao PDR from markets selling wildlife, including information on volume, form, species and price of wildlife; market biosafety and visitor origin. The potential for traded wildlife to host zoonotic diseases that pose a serious threat to human health was then evaluated at seven markets identified as having high volumes of trade. At the seven markets, during 21 observational surveys, 1,937 alive or fresh dead mammals (approximately 1,009 kg) were observed for sale, including mammals from 12 taxonomic families previously documented to be capable of hosting 36 zoonotic pathogens. In these seven markets, the combination of high wildlife volumes, high risk taxa for zoonoses and poor biosafety increases the potential for pathogen presence and transmission. To examine the potential conservation impact of trade in markets, we assessed the status of 33,752 animals observed during 375 visits to 93 markets, under the Lao PDR Wildlife and Aquatic Law. We observed 6,452 animals listed by Lao PDR as near extinct or threatened with extinction. The combined risks of wildlife trade in Lao PDR to human health and biodiversity highlight the need for a multi-sector approach to effectively protect public health, economic interests and biodiversity.

  16. Bioaccessibility of metals and human health risk assessment in community urban gardens.

    Science.gov (United States)

    Izquierdo, M; De Miguel, E; Ortega, M F; Mingot, J

    2015-09-01

    Pseudo-total (i.e. aqua regia extractable) and gastric-bioaccessible (i.e. glycine+HCl extractable) concentrations of Ca, Co, Cr, Cu, Fe, Mn, Ni, Pb and Zn were determined in a total of 48 samples collected from six community urban gardens of different characteristics in the city of Madrid (Spain). Calcium carbonate appears to be the soil property that determines the bioaccessibility of a majority of those elements, and the lack of influence of organic matter, pH and texture can be explained by their low levels in the samples (organic matter) or their narrow range of variation (pH and texture). A conservative risk assessment with bioaccessible concentrations in two scenarios, i.e. adult urban farmers and children playing in urban gardens, revealed acceptable levels of risk, but with large differences between urban gardens depending on their history of land use and their proximity to busy areas in the city center. Only in a worst-case scenario in which children who use urban gardens as recreational areas also eat the produce grown in them would the risk exceed the limits of acceptability.

  17. Distribution and health risk assessment of some organic and inorganic substances in a petroleum facility in central Mexico

    Science.gov (United States)

    Flores-Serrano, R. M.; Torres, L. G.; Flores, C.; Castro, A.; Iturbe, R.

    An oil distribution and storage station was subjected to an Environmental Auditory and results showed soil contamination in part of the surface. An assessment of the site was required in order to fulfill a complete characterization of the contaminants present in soil and groundwater, as well as to establish the probable sources of contamination. Besides, a health risk assessment was performed to set remediation goals. The aim of this work is to show how the entire characterization and risk assessment process performed in this storage station from central Mexico, regarding to subsoil and groundwater. Thirty sample points were examined. Total petroleum hydrocarbons concentrations in soil were in a very low range (20-268 mg/kg). Ethylbenzene, methyl tert-butyl ether, tert-amyl methyl ether, and lead were identified in one sampling point. Iron and zinc were found in all soil samples. There was no correlation between total petroleum hydrocarbons and any of the metals or between both metals. Only two out of four monitoring wells showed total petroleum hydrocarbons levels (1.4 and 66 mg/L, respectively). Regarding lead, all four monitored wells showed lead concentrations (0.043-0.15 mg/L). Results suggested that metal concentrations were not associated to petroleum contamination, but to iron scrap deposits placed over the soil; nevertheless more data is needed to make a clear conclusion. Health risk assessment showed that none of the evaluated contaminants represented a risk either for the on-site or the off-site receptors, since the hazardous quotients estimated did not exceed the acceptable values.

  18. Analysis of indoor air pollutants checklist using environmetric technique for health risk assessment of sick building complaint in nonindustrial workplace

    Directory of Open Access Journals (Sweden)

    Syazwan AI

    2012-09-01

    Full Text Available AI Syazwan,1 B Mohd Rafee,1 Hafizan Juahir,2 AZF Azman,1 AM Nizar,3 Z Izwyn,4 K Syahidatussyakirah,1 AA Muhaimin,5 MA Syafiq Yunos,6 AR Anita,1 J Muhamad Hanafiah,1 MS Shaharuddin,7 A Mohd Ibthisham,8 I Mohd Hasmadi,9 MN Mohamad Azhar,1 HS Azizan,1 I Zulfadhli,10 J Othman,11 M Rozalini,12 FT Kamarul131Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, 2Department of Environmental Science/ Environmental Forensics Research Center (ENFORCE, Universiti Putra Malaysia, Selangor, 3Pharmacology Unit, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, 4Department of Therapy and Rehabilitation, Faculty of Health Science and Biomedical Engineering, Universiti Teknologi Malaysia, Johor, 5Department of Environmental Management, Faculty of Environmental Studies, Universiti Putra Malaysia, Selangor, 6Plant Assessment Technology (PAT, Industrial Technology Division, Malaysian Nuclear Agency, Bangi, 7Department of Environmental and Occupational Health Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, 8Department of Mechanical Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, Johor, 9Department of Forest Production, Faculty of Forestry, Universiti Putra Malaysia, Selangor, 10Faculty of Built Environment and Architect, Universiti Teknologi Malaysia, Johor, 11Department of Counselor Education and Psychology Counseling, Faculty of Educational Studies, Universiti Putra Malaysia, Selangor, 12Occupational Safety, Health and Environment Unit, Multimedia University, Jalan Multimedia 63100 Cyberjaya, Selangor, 13ERALAB SDN. BHD. (Environmental Research and Analytical Laboratory Sdn. Bhd., Selangor, MALAYSIAPurpose: To analyze and characterize a multidisciplinary, integrated indoor air quality checklist for evaluating the health risk of building occupants in a nonindustrial

  19. Prognostic Health Monitoring System: Component Selection Based on Risk Criteria and Economic Benefit Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Binh T. Pham; Vivek Agarwal; Nancy J Lybeck; Magdy S Tawfik

    2012-05-01

    Prognostic health monitoring (PHM) is a proactive approach to monitor the ability of structures, systems, and components (SSCs) to withstand structural, thermal, and chemical loadings over the SSCs planned service lifespans. The current efforts to extend the operational license lifetime of the aging fleet of U.S. nuclear power plants from 40 to 60 years and beyond can benefit from a systematic application of PHM technology. Implementing a PHM system would strengthen the safety of nuclear power plants, reduce plant outage time, and reduce operation and maintenance costs. However, a nuclear power plant has thousands of SSCs, so implementing a PHM system that covers all SSCs requires careful planning and prioritization. This paper therefore focuses on a component selection that is based on the analysis of a component's failure probability, risk, and cost. Ultimately, the decision on component selection depend on the overall economical benefits arising from safety and operational considerations associated with implementing the PHM system.

  20. Assessment of heavy metal pollution and human health risk in urban soils of steel industrial city (Anshan), Liaoning, Northeast China.

    Science.gov (United States)

    Qing, Xiao; Yutong, Zong; Shenggao, Lu

    2015-10-01

    The purpose of this study was to determine the concentrations and health risk of heavy metals in urban soils from a steel industrial district in China. A total of 115 topsoil samples from Anshan city, Liaoning, Northeast China were collected and analyzed for Cr, Cd, Pb, Zn, Cu, and Ni. The geoaccumulation index (Igeo), pollution index (PI), and potential ecological risk index (PER) were calculated to assess the pollution level in soils. The hazard index (HI) and carcinogenic risk (RI) were used to assess human health risk of heavy metals. The average concentration of Cr, Cd, Pb, Zn, Cu, and Ni were 69.9, 0.86, 45.1, 213, 52.3, and 33.5mg/kg, respectively. The Igeo and PI values of heavy metals were in the descending order of Cd>Zn>Cu>Pb>Ni>Cr. Higher Igeo value for Cd in soil indicated that Cd pollution was moderate. Pollution index indicated that urban soils were moderate to highly polluted by Cd, Zn, Cu, and Pb. The spatial distribution maps of heavy metals revealed that steel industrial district was the contamination hotspots. Principal component analysis (PCA) and matrix cluster analysis classified heavy metals into two groups, indicating common industrial sources for Cu, Zn, Pb, and Cd. Matrix cluster analysis classified the sampling sites into four groups. Sampling sites within steel industrial district showed much higher concentrations of heavy metals compared to the rest of sampling sites, indicating significant contamination introduced by steel industry on soils. The health risk assessment indicated that non-carcinogenic values were below the threshold values. The hazard index (HI) for children and adult has a descending order of Cr>Pb>Cd>Cu>Ni>Zn. Carcinogenic risks due to Cr, Cd, and Ni in urban soils were within acceptable range for adult. Carcinogenic risk value of Cr for children is slightly higher than the threshold value, indicating that children are facing slight threat of Cr. These results provide basic information of heavy metal pollution control

  1. Assessment of health risks brought about by transportation of spent fuel; Kaeytetyn ydinpolttoaineen kuljetusten terveysriskien arviointi

    Energy Technology Data Exchange (ETDEWEB)

    Suolanen, V.; Lautkaski, R.; Rossi, J. [VTT Energy, Espoo (Finland)

    1999-03-01

    In the study health risks caused by transportation of spent fuel from Olkiluoto and from Loviisa NPP`s to the planned disposal site have been evaluated. The Olkiluoto NPP is owned by Teollisuuden Voima Oy (TVO) and the Loviisa NPP, situated at Haestholmen, by Fortum Power and Heat Oy. According to the base scenario of 40 years use of the current NPP`s the total amount of spent fuel will be 1840 tU (TVO) and 860 tU (Fortum). Annually, 110 tU on the average and at most 250 tU will be transported to the disposal site. The considered transportation routes are from Olkiluoto to Haestholmen, from Olkiluoto to Kivetty, from Olkiluoto to Romuvaara, from Haestholmen to Olkiluoto, from Haestholmen to Kivetty and from Haestholmen to Romuvaara. The considered transportation modes are truck, rail or ship, or combinations of these modes. Each transportation route has been divided into homogenised sequences with respect to population density and/or route type. Total amount of analysed route options were 40, some route sequences are overlapping. Radiation exposures to the population along the routes have been calculated in normal, incident and accident situations during transportation. Occupational radiation doses to the personnel have been estimated for normal transportation only. The consequences of normal transportation have been evaluated based on RADTRAN-model, developed by the Sandia National Laboratories. As incidents, stopping of spent fuel transportation for an exceptionally long period of time, and in another case contamination of outer surface of spent fuel cask have been considered. Expected collective doses and health risks of transportation accidents connected to the routes have been calculated with RADTRAN-model. Single hypothetical transport accidents with pessimistic release assumptions have been further analysed in more detail with the ARANO-model, developed by VTT (Technical Research Centre of Finland). (orig.) 9 refs.

  2. Occurrence and health risk assessment of halogenated disinfection byproducts in indoor swimming pool water.

    Science.gov (United States)

    Hang, Chen; Zhang, Beibei; Gong, Tingting; Xian, Qiming

    2016-02-01

    Swimming pool disinfection byproducts (DBPs) have become a concern in many countries all over the world. In this study, the concentrations of several categories of DBPs, including trihalomethanes (THMs), haloacetic acids (HAAs), haloacetonitriles (HANs), haloketones (HKs) and trichloronitromethane (TCNM), in 13 public indoor swimming pools in Nanjing, China were determined, the correlations between DBPs and water quality parameters as well as between different DBP categories were evaluated, and the health risks of the DBPs to human were examined. The results indicate that the DBP levels in the swimming pools in Nanjing were relatively high, with HAAs as the most dominant category, followed by THMs, HANs, HKs and TCNM sequentially. Bromochloroacetic acid (BCAA), trichloromethane (TCM), dichloroacetonitrile (DCAN), and 1,1,1-trichloropropanone (1,1,1-TCP) were the most dominant species among HAAs, THMs, HANs, and HKs, respectively. For all the different categories of DBPs, the concentrations in the pool disinfected with ozonation/chlorination were lower than those in the pool disinfected with chlorination. The DBP levels were generally not affected by the number of swimmers and the DBP levels on different dates were relatively stable. Besides, the chlorine residual seemed to be a critical concern in most of the swimming pools in this study. Moreover, there were some correlations between DBPs and water quality parameters as well as between different DBP categories. It is to be noted that the predicted cancer and health risks of the DBPs in these swimming pools were generally higher than the regulatory limits by USEPA, and thus DBPs in these swimming pools should be concerned.

  3. An assessment of health risks associated with arsenic exposure via consumption of homegrown vegetables near contaminated glassworks sites.

    Science.gov (United States)

    Uddh-Söderberg, Terese E; Gunnarsson, Sara J; Hogmalm, K Johan; Lindegård, M I Boel G; Augustsson, Anna L M

    2015-12-01

    The health risk posed by arsenic in vegetables grown in private gardens near 22 contaminated glassworks sites was investigated in this study. Firstly, vegetable (lettuce and potato) and soil samples were collected and arsenic concentrations measured to characterize the arsenic uptake in the selected crops. Secondly, a probabilistic exposure assessment was conducted to estimate the average daily intake (ADIveg), which was then evaluated against toxicological reference values by the calculation of hazard quotients (HQs) and cancer risks (CRs). The results show that elevated arsenic concentrations in residential garden soils are mirrored by elevated concentrations in vegetables, and that consumption of these vegetables alone may result in an unacceptable cancer risk; the calculated reasonable maximum exposure, for example, corresponded to a cancer incidence 20 times higher than the stated tolerance limit. However, the characterization of risk depends to a great extent on which toxicological reference value is used for comparison, as well as how the exposure is determined. Based on the assumptions made in the present study, the threshold levels for chronic non-carcinogenic or acute effects were not exceeded, but the cancer risks indicated highlight the need for further exposure studies, as dietary intake involves more than just homegrown vegetables and total exposure is a function of more than just one exposure pathway. In addition, glassworks sites--and contaminated sites in general--contain multiple contaminants, affecting the final and total risk.

  4. Arsenic contamination in the freshwater fish ponds of Pearl River Delta: bioaccumulation and health risk assessment.

    Science.gov (United States)

    Cheng, Zhang; Chen, Kun-Ci; Li, Kai-Bin; Nie, Xiang-Ping; Wu, Sheng Chun; Wong, Chris Kong-Chu; Wong, Ming-Hung

    2013-07-01

    This study investigated the extent of arsenic (As) contamination in five common species of freshwater fish (northern snakehead [Channa argus], mandrarin fish [Siniperca chuatsi], largemouth bass [Lepomis macrochirous], bighead carp [Aristichthys nobilis] and grass carp [Ctenopharyngodon idellus]) and their associated fish pond sediments collected from 18 freshwater fish ponds around the Pearl River Delta (PRD). The total As concentrations detected in fish muscle and sediment in freshwater ponds around the PRD were 0.05-3.01 mg kg(-1) wet weight (w. wt) and 8.41-22.76 mg kg(-1) dry weight (d. wt), respectively. In addition, the As content was positively correlated (p < 0.05) to total organic carbon (TOC) contents in sediments. Biota sediment accumulation factor (BSAF) showed that omnivorous fish and zooplankton accumulated higher concentrations of heavy metals from the sediment than carnivorous fish. In addition, feeding habits of fish also influence As accumulation in different fish species. In this study, two typical food chains of the aquaculture ponds were selected for investigation: (1) omnivorous food chain (zooplankton, grass carp and bighead carp) and (2) predatory food chain (zooplankton, mud carp and mandarin fish). Significant linear relationships were obtained between log As and δ (15)N. The slope of the regression (-0.066 and -0.078) of the log transformed As concentrations and δ (15)N values, as biomagnifications power, indicated there was no magnification or diminution of As from lower trophic levels (zooplankton) to fish in the aquaculture ponds. Consumption of largemouth bass, northern snakehead and bighead carp might impose health risks of Hong Kong residents consuming these fish to the local population, due to the fact that its cancer risk (CR) value exceeded the upper limit of the acceptable risk levels (10(-4)) stipulated by the USEPA.

  5. [Contamination of Organophosphorus Pesticides Residue in Fresh Vegetables and Related Health Risk Assessment in Changchun, China].

    Science.gov (United States)

    Yu, Rui; Liu, Jing-shuang; Wang, Qi-cun; Liu, Qiang; Wang, Yang

    2015-09-01

    This study aims to investigate the concentrations of organophosphorus pesticides (OPs) in fresh vegetables. A total of Z14 samples from seven types of vegetables were collected from the suburb in Changchun City. The OPs were analyzed by gas chromatography coupled with flame photometric detector (GC-FPD). Target hazard quotients (THQ) were applied to estimate the potential health risk to inhabitants. Results showed that OPs concentrations exceeded the Maximum Residue Limit (MRL) in more than 23. 4% samples, and were not detected in only 7. 9% samples. Detection rates of OPs was as follow in the decreased order: diazinon (82. 2%) > phorate (45. 8%) > dimethoate (29. 4%) > parathion-methyl (27. 6%) > omethoate (23. 8%) > dichlorvos (22. 9%) > fenitrothion (21%) > fenthion (18. 7%) > parathion (18. 2%) > methamidophos (17. 3%) > malathion (12. 1%). The percentages above MRL for leaves were higher than for non-leafy vegetables. The order of percentages of OPs above MRL was as follows: green onion (82. 5%) > radish (37. 5%) > red pepper (17. 2%) > Chinese vegetable (14. 3%) > cucumber (3. 2%) > eggplant (2. 9%) > tomato (0%). 49. 5% vegetables samples showed more than one OP. The average target hazard quotients (ave THQ) were all less than one and the average Hazard Index (ave HI) was 0. 462, so that inhabitants who expose average OP levels may not experience adverse health effects.

  6. Heart health risk assessment system: a nonintrusive proposal using ontologies and expert rules.

    Science.gov (United States)

    Garcia-Valverde, Teresa; Muñoz, Andrés; Arcas, Francisco; Bueno-Crespo, Andrés; Caballero, Alberto

    2014-01-01

    According to the World Health Organization, the world's leading cause of death is heart disease, with nearly two million deaths per year. Although some factors are not possible to change, there are some keys that help to prevent heart diseases. One of the most important keys is to keep an active daily life, with moderate exercise. However, deciding what a moderate exercise is or when a slightly abnormal heart rate value is a risk depends on the person and the activity. In this paper we propose a context-aware system that is able to determine the activity the person is performing in an unobtrusive way. Then, we have defined ontology to represent the available knowledge about the person (biometric data, fitness status, medical information, etc.) and her current activity (level of intensity, heart rate recommended for that activity, etc.). With such knowledge, a set of expert rules based on this ontology are involved in a reasoning process to infer levels of alerts or suggestions for the users when the intensity of the activity is detected as dangerous for her health. We show how this approach can be accomplished by using only everyday devices such as a smartphone and a smartwatch.

  7. Heart Health Risk Assessment System: A Nonintrusive Proposal Using Ontologies and Expert Rules

    Directory of Open Access Journals (Sweden)

    Teresa Garcia-Valverde

    2014-01-01

    Full Text Available According to the World Health Organization, the world’s leading cause of death is heart disease, with nearly two million deaths per year. Although some factors are not possible to change, there are some keys that help to prevent heart diseases. One of the most important keys is to keep an active daily life, with moderate exercise. However, deciding what a moderate exercise is or when a slightly abnormal heart rate value is a risk depends on the person and the activity. In this paper we propose a context-aware system that is able to determine the activity the person is performing in an unobtrusive way. Then, we have defined ontology to represent the available knowledge about the person (biometric data, fitness status, medical information, etc. and her current activity (level of intensity, heart rate recommended for that activity, etc.. With such knowledge, a set of expert rules based on this ontology are involved in a reasoning process to infer levels of alerts or suggestions for the users when the intensity of the activity is detected as dangerous for her health. We show how this approach can be accomplished by using only everyday devices such as a smartphone and a smartwatch.

  8. An assessment of health risks and mortality from exposure to secondhand smoke in Chinese restaurants and bars.

    Directory of Open Access Journals (Sweden)

    Ruiling Liu

    Full Text Available INTRODUCTION: Smoking is generally not regulated in restaurants or bars in China, or the restrictions are not fully implemented if there are any, while the related hazard health effects are not recognized by the majority of the Chinese population. OBJECTIVES: This study aims to assess the excess health risks and mortality attributed to secondhand smoke (SHS exposure in restaurants and bars for both servers and patrons to provide necessary evidence for advancing tobacco control in this microenvironment. METHODS: Two approaches were used for the assessment. One is a continuous approach based on existing field measurements and Repace and Lowrey's dose-response model, and the other is a categorical approach based on exposure or not and epidemiological studies. RESULTS: Based on the continuous approach, servers were estimated to have a lifetime excess risk (LER of lung cancer death (LCD of 730 to 1,831×10(-6 for working five days a week for 45 years in smoking restaurants and 1,862 to 8,136×10(-6 in smoking bars, and patrons could have a LER of LCD of 47 to 117×10(-6 due to visiting smoking restaurants for an average of 13 minutes a day for 60 years, and 119 to 522×10(-6 due to visiting smoking bars. The categorical approach estimated that SHS exposure in restaurants and bars alone caused 84 LCD and 57 ischemic heart disease (IHD deaths among nonsmoking servers and 1,2419 LCDs and 1,689 IHD deaths among the nonsmoking patron population. CONCLUSIONS: SHS exposure in restaurants and bars alone can impose high lifetime excess risks of lung cancer death and ischemic heart disease deaths to both servers and patrons, and can cause a significant number of deaths each year in China. These health risks and deaths can be prevented by banning smoking in restaurants and bars and effectively implementing these smoking bans.

  9. An Integrated Approach to Assess Exposure and Health-Risk from Polycyclic Aromatic Hydrocarbons (PAHs in a Fastener Manufacturing Industry

    Directory of Open Access Journals (Sweden)

    Hsin-I Hsu

    2014-09-01

    Full Text Available An integrated approach was developed to assess exposure and health-risk from polycyclic aromatic hydrocarbons (PAHs contained in oil mists in a fastener manufacturing industry. One previously developed model and one new model were adopted for predicting oil mist exposure concentrations emitted from metal work fluid (MWF and PAHs contained in MWF by using the fastener production rate (Pr and cumulative fastener production rate (CPr as predictors, respectively. By applying the annual Pr and CPr records to the above two models, long-term workplace PAH exposure concentrations were predicted. In addition, true exposure data was also collected from the field. The predicted and measured concentrations respectively served as the prior and likelihood distributions in the Bayesian decision analysis (BDA, and the resultant posterior distributions were used to determine the long-term exposure and health-risks posed on workers. Results show that long term exposures to PAHs would result in a 3.1%, 96.7%, and 73.4% chance of exceeding the PEL-TWA (0.2 mg/m3, action level (0.1 mg/m3, and acceptable health risk (10−3, respectively. In conclusion, preventive measures should be taken immediately to reduce workers’ PAH exposures.

  10. Dispersion modeling and health risk assessment of dioxin emissions from a municipal solid waste incinerator in Hangzhou, China

    Institute of Scientific and Technical Information of China (English)

    Xiao-jun MA; Xu-guang JIANG; Yu-qi JIN; Hong-mei LIU; Xiao-dong LI; Tong CHEN; Jian-hua YAN

    2012-01-01

    The emission of dioxins from municipal solid waste incinerators (MSWIs) has become a widespread concern.The effect of meteorological parameters (wind speed,atmospheric stability and mixing height) on the hourly ground level concentration (GLC) of dioxins was estimated using air dispersion models.Moreover,the health risks of dioxin exposure were evaluated for children and adults using the Nouwen equation.The total environmental exposure via air inhalation and food mgestion was calculated,based on linear fit equations.The results indicate that potentially severe pollution from dioxins occurs at a wind speed of 1.5 m/s with atmospheric stability class F.In addition,local residents in the study area are exposed to severe weather conditions most of the time,and the risk exposures for children are far higher than those for adults.The total exposure for children far exceeds the tolerable daily intake of dioxin recommended by the World Health Organization (WHO) of 1-4 pg TEQ/(kg·d) under severe weather conditions.Results from modeling calculations of health risk assessment were consistent with dioxin levels obtained during actual monitoring of emissions.

  11. Dose-response modeling : Evaluation, application, and development of procedures for benchmark dose analysis in health risk assessment of chemical substances

    OpenAIRE

    Sand, Salomon

    2005-01-01

    In this thesis, dose-response modeling and procedures for benchmark dose (BMD) analysis in health risk assessment of chemical substances have been investigated. The BMD method has been proposed as an alternative to the NOAEL (no-observedadverse- effect-level) approach in health risk assessment of non-genotoxic agents. According to the BMD concept, a dose-response model is fitted to data and the BMD is defined as the dose causing a predetermined change in response. A lowe...

  12. Wastewater treatment and public health in Nunavut: a microbial risk assessment framework for the Canadian Arctic

    DEFF Research Database (Denmark)

    Daley, Kiley; Jamieson, Rob; Rainham, Daniel

    2017-01-01

    . This review offers a conceptual framework and evaluation of current knowledge to enable the first microbial risk assessment of exposure scenarios associated with food-harvesting and recreational activities in Arctic communities, where simplified wastewater systems are being operated.......Wastewater management in Canadian Arctic communities is influenced by several geographical factors including climate, remoteness, population size, and local food-harvesting practices. Most communities use trucked collection services and basic treatment systems, which are capable of only low...... into the terrestrial and aquatic environment at random times. Northern communities rely heavily on their local surroundings as a source of food, drinking water, and recreation, thus creating the possibility of human exposure to wastewater effluent. Human exposure to microbial hazards present in municipal wastewater...

  13. Issues in the assessment of congenital health risks from mercury in coal

    Energy Technology Data Exchange (ETDEWEB)

    Lipfert, F.W.; Moskowitz, P.D. [Brookhaven National Lab., Upton, NY (United States); Saroff, L. [USDOE Assistant Secretary for Fossil Energy, Washington, DC (United States). Clean Coal Technology Program

    1995-04-01

    This paper describes a probabilistic assessment of congenital neurological risks associated with consumption of fish and shellfish containing MeHg and the effects that local coal combustion might have on those risks. Two scenarios were considered with this model: the ``baseline`` scenario (MeHg from fish consumption without local impacts), and the ``impact`` scenario (baseline plus local power-plant impact on freshwater fish). In this paper, we describe the framework and application of the model, including parameters and statistical linkages, the distributions used to represent the parameters, and the statistical methods used to characterize the inherent variability in each individual`s diet and the distribution of individuals within a hypothetical population. These factors define the baseline, which is then compared to observations of MeHg in hair in order to demonstrate the model`s validity. The incremental effect of local coal combustion is represented by augmenting the distribution of Hg in local freshwater fish by a prescribed amount, which we refer to as the ``impact factor.`` Conventional air pollution dispersion modeling is then used to relate this factor to an appropriate range of powerplant characteristics.

  14. A comprehensive assessment of arsenic in commonly consumed foodstuffs to evaluate the potential health risk in Bangladesh.

    Science.gov (United States)

    Ahmed, Md Kawser; Shaheen, Nazma; Islam, Md Saiful; Habibullah-Al-Mamun, Md; Islam, Saiful; Islam, Md Monirul; Kundu, Goutam Kumar; Bhattacharjee, Lalita

    2016-02-15

    Arsenic (As), particularly of its inorganic form (iAs) is highly toxic, and its presence in food composites is a matter of concern for the public health safety, specifically in Bangladesh which is regarded as the most arsenic affected country throughout the world. This study was carried out to investigate the levels of As in the composite samples of commonly consumed foodstuffs collected from 30 different agro-ecological zones for the first time in Bangladesh. Most of the individual food composites contain a considerable amount of As which was, as a whole, in the range of 0.077-1.5mg/kg fw which was lower than those reported from Spain, EU, France, Korea, whereas higher than those of Mexico, Chile, Japan, Cambodia, Hong Kong, Serbia, respectively. Cereals, vegetables, milk, and fish contribute about 90% to the daily intake of inorganic arsenic. Human health risk of dietary iAs was assessed separately for both the rural and urban adults. The estimated daily dietary intakes (EDI) of iAs for the exposed rural (3.5) and urban residents (3.2 μg/kg-BW/day) clearly exceeded the previous provisional tolerable daily intake (PTDI) value of 2.1 μg/kg-BW/day, recommended by the World Health Organization (WHO). From the health point of view, this study concluded that both the rural and urban residents of Bangladesh are exposed to carcinogenic and non-carcinogenic risks who consume As-contaminated water and foodstuffs.

  15. Cancer Genetics Risk Assessment and Counseling (PDQ®)—Health Professional Version

    Science.gov (United States)

    Expert-reviewed information summary in which cancer risk perception, risk communication, and risk counseling are discussed. The summary also contains information about recording and analyzing a family history of cancer and factors to consider when offering genetic testing.

  16. Human health risk assessment of heavy metals in soil–vegetable system: A multi-medium analysis

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xingmei; Song, Qiujin; Tang, Yu; Li, Wanlu [College of Environmental and Natural Resource Sciences, Zhejiang Provincial Key Laboratory of Subtropical Soil and Plant Nutrition, Zhejiang University, Hangzhou 310058 (China); Xu, Jianming, E-mail: jmxu@zju.edu.cn [College of Environmental and Natural Resource Sciences, Zhejiang Provincial Key Laboratory of Subtropical Soil and Plant Nutrition, Zhejiang University, Hangzhou 310058 (China); Wu, Jianjun, E-mail: wujianjun@zju.edu.cn [College of Environmental and Natural Resource Sciences, Zhejiang Provincial Key Laboratory of Subtropical Soil and Plant Nutrition, Zhejiang University, Hangzhou 310058 (China); Wang, Fan [College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036 (China); Brookes, Philip Charles [College of Environmental and Natural Resource Sciences, Zhejiang Provincial Key Laboratory of Subtropical Soil and Plant Nutrition, Zhejiang University, Hangzhou 310058 (China)

    2013-10-01

    Vegetable fields near villages in China are suffering increasing heavy metal damages from various pollution sources including agriculture, traffic, mining and Chinese typical local private family-sized industry. 268 vegetable samples which included rape, celery, cabbages, carrots, asparagus lettuces, cowpeas, tomatoes and cayenne pepper and their corresponding soils in three economically developed areas of Zhejiang Province, China were collected, and the concentrations of five heavy metals (Pb, Cd, Cr, Hg and As) in all the samples were determined. The health risk assessment methods developed by the United States Environmental Protection Agency (US EPA) were employed to explore the potential health hazards of heavy metals in soils growing vegetables. Results showed that heavy metal contaminations in investigated vegetables and corresponding soils were significant. Pollution levels varied with metals and vegetable types. The highest mean soil concentrations of heavy metals were 70.36 mg kg{sup −1} Pb, 47.49 mg kg{sup −1} Cr, 13.51 mg kg{sup −1} As, 0.73 mg kg{sup −1} for Cd and 0.67 mg kg{sup −1} Hg, respectively, while the metal concentrations in vegetables and corresponding soils were poorly correlated. The health risk assessment results indicated that diet dominated the exposure pathways, so heavy metals in soil samples might cause potential harm through food-chain transfer. The total non-cancer and cancer risk results indicated that the investigated arable fields near industrial and waste mining sites were unsuitable for growing leaf and root vegetables in view of the risk of elevated intakes of heavy metals adversely affecting food safety for local residents. Chromium and Pb were the primary heavy metals posing non-cancer risks while Cd caused the greatest cancer risk. It was concluded that more effective controls should be focused on Cd and Cr to reduce pollution in this study area. - Highlights: • Flourishing private economy caused increasing

  17. [Health risk assessment in the metal scrap recycle: the case of Brescia].

    Science.gov (United States)

    Corsaro, G B; Gabusi, V; Pilisi, A

    2012-01-01

    The recycle of metal scraps is one of the most important industrial activity of Brescia: almost 40% of the metal scraps produced in Italy are reprocessed in this Province. The melting process currently used produces air emissions containing dioxins, PCB and other pollutants which are dispersed in the atmosphere giving a contribution to the general environment pollution. This contribution has been and is being extensively studied in terms of air concentration and soil deposition but, because of its complexity and the difficulty to gather the necessary data, very little investigation has been made up to now on its impact on the health of workers and population. The difficulties are overcome by RAMET, a research Consortium established and financed by the main 24 metallurgical and siderurgical companies of Brescia, which can take advantage of the availability of the production facilities of its shareholders as pilot plants and has access to their database and experience. Starting from this unique favourable condition and in collaboration with the University of Brescia, RAMET is working on a research project having as main objective the assessment of the POPs dose adsorbed and the relevant consequences on workers and public health. The general scheme and organization of this project are given in this paper together with the outlines and the results of the main activities already completed or in progress.

  18. Quantitative microbiological risk assessment.

    Science.gov (United States)

    Hoornstra, E; Notermans, S

    2001-05-21

    The production of safe food is being increasingly based on the use of risk analysis, and this process is now in use to establish national and international food safety objectives. It is also being used more frequently to guarantee that safety objectives are met and that such guarantees are achieved in a cost-effective manner. One part of the overall risk analysis procedure-risk assessment-is the scientific process in which the hazards and risk factors are identified, and the risk estimate or risk profile is determined. Risk assessment is an especially important tool for governments when food safety objectives have to be developed in the case of 'new' contaminants in known products or known contaminants causing trouble in 'new' products. Risk assessment is also an important approach for food companies (i) during product development, (ii) during (hygienic) process optimalization, and (iii) as an extension (validation) of the more qualitative HACCP-plan. This paper discusses these two different types of risk assessment, and uses probability distribution functions to assess the risks posed by Escherichia coli O157:H7 in each case. Such approaches are essential elements of risk management, as they draw on all available information to derive accurate and realistic estimations of the risk posed. The paper also discusses the potential of scenario-analysis in simulating the impact of different or modified risk factors during the consideration of new or improved control measures.

  19. Human health risk assessment of CO2 leakage into overlying aquifers using a stochastic, geochemical reactive transport approach.

    Science.gov (United States)

    Atchley, Adam L; Maxwell, Reed M; Navarre-Sitchler, Alexis K

    2013-06-04

    Increased human health risk associated with groundwater contamination from potential carbon dioxide (CO2) leakage into a potable aquifer is predicted by conducting a joint uncertainty and variability (JUV) risk assessment. The approach presented here explicitly incorporates heterogeneous flow and geochemical reactive transport in an efficient manner and is used to evaluate how differences in representation of subsurface physical heterogeneity and geochemical reactions change the calculated risk for the same hypothetical aquifer scenario where a CO2 leak induces increased lead (Pb(2+)) concentrations through dissolution of galena (PbS). A nested Monte Carlo approach was used to take Pb(2+) concentrations at a well from an ensemble of numerical reactive transport simulations (uncertainty) and sample within a population of potentially exposed individuals (variability) to calculate risk as a function of both uncertainty and variability. Pb(2+) concentrations at the well were determined with numerical reactive transport simulation ensembles using a streamline technique in a heterogeneous 3D aquifer. Three ensembles with variances of log hydraulic conductivity (σ(2)lnK) of 1, 3.61, and 16 were simulated. Under the conditions simulated, calculated risk is shown to be a function of the strength of subsurface heterogeneity, σ(2)lnK and the choice between calculating Pb(2+) concentrations in groundwater using equilibrium with galena and kinetic mineral reaction rates. Calculated risk increased with an increase in σ(2)lnK of 1 to 3.61, but decreased when σ(2)lnK was increased from 3.61 to 16 for all but the highest percentiles of uncertainty. Using a Pb(2+) concentration in equilibrium with galena under CO2 leakage conditions (PCO2 = 30 bar) resulted in lower estimated risk than the simulations where Pb(2+) concentrations were calculated using kinetic mass transfer reaction rates for galena dissolution and precipitation. This study highlights the importance of

  20. Risk Assessment Overview

    Science.gov (United States)

    Prassinos, Peter G.; Lyver, John W., IV; Bui, Chinh T.

    2011-01-01

    Risk assessment is used in many industries to identify and manage risks. Initially developed for use on aeronautical and nuclear systems, risk assessment has been applied to transportation, chemical, computer, financial, and security systems among others. It is used to gain an understanding of the weaknesses or vulnerabilities in a system so modification can be made to increase operability, efficiency, and safety and to reduce failure and down-time. Risk assessment results are primary inputs to risk-informed decision making; where risk information including uncertainty is used along with other pertinent information to assist management in the decision-making process. Therefore, to be useful, a risk assessment must be directed at specific objectives. As the world embraces the globalization of trade and manufacturing, understanding the associated risk become important to decision making. Applying risk assessment techniques to a global system of development, manufacturing, and transportation can provide insight into how the system can fail, the likelihood of system failure and the consequences of system failure. The risk assessment can identify those elements that contribute most to risk and identify measures to prevent and mitigate failures, disruptions, and damaging outcomes. In addition, risk associated with public and environment impact can be identified. The risk insights gained can be applied to making decisions concerning suitable development and manufacturing locations, supply chains, and transportation strategies. While risk assessment has been mostly applied to mechanical and electrical systems, the concepts and techniques can be applied across other systems and activities. This paper provides a basic overview of the development of a risk assessment.

  1. Ecological risk assessment of heavy metals in sediment and human health risk assessment of heavy metals in fishes in the middle and lower reaches of the Yangtze River basin

    Energy Technology Data Exchange (ETDEWEB)

    Yi Yujun [State Key Laboratory of Water Environment Simulation and Pollution Control, School of Environment, Beijing Normal University, Beijing 100875 (China); Yang Zhifeng, E-mail: zfyang@bnu.edu.cn [State Key Laboratory of Water Environment Simulation and Pollution Control, School of Environment, Beijing Normal University, Beijing 100875 (China); Zhang Shanghong [Renewable Energy School, North China Electric Power University, Beijing 102206 (China)

    2011-10-15

    The concentrations of heavy metals (Cr, Cd, Hg, Cu, Zn, Pb and As) in the water, sediment, and fish were investigated in the middle and lower reaches of the Yangtze River, China. Potential ecological risk analysis of sediment heavy metal concentrations indicated that six sites in the middle reach, half of the sites in the lower reach, and two sites in lakes, posed moderate or considerable ecological risk. Health risk analysis of individual heavy metals in fish tissue indicated safe levels for the general population and for fisherman but, in combination, there was a possible risk in terms of total target hazard quotients. Correlation analysis and PCA found that heavy metals (Hg, Cd, Pb, Cr, Cu, and Zn) may be mainly derived from metal processing, electroplating industries, industrial wastewater, and domestic sewage. Hg may also originate from coal combustion. Significant positive correlations between TN and As were observed. - Highlights: > Field survey, test and relationship of the concentrations of heavy metals in the water, sediment, and fish. > Potential ecological risk assessment of heavy metals in sediment. > Non-cancer health risk assessment of heavy metals in fish tissue. > Possible pollution source of heavy metals analyzed. - Possible ecological risk of sediment and slight non-cancer health risk of eating fish were found in the middle and lower reaches of the Yangtze River.

  2. Biomass burning in the Amazon region: Aerosol source apportionment and associated health risk assessment

    Science.gov (United States)

    de Oliveira Alves, Nilmara; Brito, Joel; Caumo, Sofia; Arana, Andrea; de Souza Hacon, Sandra; Artaxo, Paulo; Hillamo, Risto; Teinilä, Kimmo; Batistuzzo de Medeiros, Silvia Regina; de Castro Vasconcellos, Pérola

    2015-11-01

    The Brazilian Amazon represents about 40% of the world's remaining tropical rainforest. However, human activities have become important drivers of disturbance in that region. The majority of forest fire hotspots in the Amazon arc due to deforestation are impacting the health of the local population of over 10 million inhabitants. In this study we characterize western Amazonia biomass burning emissions through the quantification of 14 Polycyclic Aromatic Hydrocarbons (PAHs), Organic Carbon, Elemental Carbon and unique tracers of biomass burning such as levoglucosan. From the PAHs dataset a toxic equivalence factor is calculated estimating the carcinogenic and mutagenic potential of biomass burning emissions during the studied period. Peak concentration of PM10 during the dry seasons was observed to reach 60 μg m-3 on the 24 h average. Conversely, PM10 was relatively constant throughout the wet season indicating an overall stable balance between aerosol sources and sinks within the filter sampling resolution. Similar behavior is identified for OC and EC components. Levoglucosan was found in significant concentrations (up to 4 μg m-3) during the dry season. Correspondingly, the estimated lung cancer risk calculated during the dry seasons largely exceeded the WHO health-based guideline. A source apportionment study was carried out through the use of Absolute Principal Factor Analysis (APFA), identifying a three-factor solution. The biomass burning factor is found to be the dominating aerosol source, having 75.4% of PM10 loading. The second factor depicts an important contribution of several PAHs without a single source class and therefore was considered as mixed sources factor, contributing to 6.3% of PM10. The third factor was mainly associated with fossil fuel combustion emissions, contributing to 18.4% of PM10. This work enhances the knowledge of aerosol sources and its impact on climate variability and local population, on a site representative of the

  3. Using Campylobacter spp. and Escherichia coli data and Bayesian microbial risk assessment to examine public health risks in agricultural watersheds under tile drainage management.

    Science.gov (United States)

    Schmidt, P J; Pintar, K D M; Fazil, A M; Flemming, C A; Lanthier, M; Laprade, N; Sunohara, M D; Simhon, A; Thomas, J L; Topp, E; Wilkes, G; Lapen, D R

    2013-06-15

    Human campylobacteriosis is the leading bacterial gastrointestinal illness in Canada; environmental transmission has been implicated in addition to transmission via consumption of contaminated food. Information about Campylobacter spp. occurrence at the watershed scale will enhance our understanding of the associated public health risks and the efficacy of source water protection strategies. The overriding purpose of this study is to provide a quantitative framework to assess and compare the relative public health significance of watershed microbial water quality associated with agricultural BMPs. A microbial monitoring program was expanded from fecal indicator analyses and Campylobacter spp. presence/absence tests to the development of a novel, 11-tube most probable number (MPN) method that targeted Campylobacter jejuni, Campylobacter coli, and Campylobacter lari. These three types of data were used to make inferences about theoretical risks in a watershed in which controlled tile drainage is widely practiced, an adjacent watershed with conventional (uncontrolled) tile drainage, and reference sites elsewhere in the same river basin. E. coli concentrations (MPN and plate count) in the controlled tile drainage watershed were statistically higher (2008-11), relative to the uncontrolled tile drainage watershed, but yearly variation was high as well. Escherichia coli loading for years 2008-11 combined were statistically higher in the controlled watershed, relative to the uncontrolled tile drainage watershed, but Campylobacter spp. loads for 2010-11 were generally higher for the uncontrolled tile drainage watershed (but not statistically significant). Using MPN data and a Bayesian modelling approach, higher mean Campylobacter spp. concentrations were found in the controlled tile drainage watershed relative to the uncontrolled tile drainage watershed (2010, 2011). A second-order quantitative microbial risk assessment (QMRA) was used, in a relative way, to identify

  4. [Risk assessment of chemical agents].

    Science.gov (United States)

    Cottica, Danilo; Grignani, Elena; Bartolucci, Giovanni Battista

    2011-01-01

    The risk assessment of chemical agents is a well known and applied process carried out by Industrial Hygienists and Occupational Physicians based on exposure evaluation. The application of REACH (CE 1907/2006), CLP (CE 1272/2008) and SDS (UE 453/2010) introduces some changes and instruments to carry out the occupational exposure assessment, like new classification of substances, Exposure Scenario, suggested control measures that the Industrial Hygienist and the Occupational Physician must evaluate. If there is not a similar Exposure Scenario to apply a new risk assessment must carried out also by recommended software (ECETOC Targeted Risk Assessment; Easy to use workplace EMKG; Stoffenmanager). Looking at the relevance of the control measures and evaluation of Exposure Scenario we report the flowchart of risk assessment and management by the Method of Organisational Congruencies carried out with the Prevention and Protection Service and Occupational Physician Office of the Health Service of the Azienda Provinciale of Trento.

  5. Biosafety Risk Assessment Methodology

    Energy Technology Data Exchange (ETDEWEB)

    Caskey, Susan Adele [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). International Biological Threat Reduction Program; Gaudioso, Jennifer M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). International Biological Threat Reduction Program; Salerno, Reynolds Mathewson [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). International Biological Threat Reduction Program; Wagner, Stefan M. [Public Health Agency of Canada, Winnipeg, MB (Canada). Canadian Science Centre for Human and Animal Health (CSCHAH); Shigematsu, Mika [National Inst. of Infectious Diseases (NIID), Tokyo (Japan); Risi, George [Infectious Disease Specialists, P.C, Missoula, MT (United States); Kozlovac, Joe [US Dept. of Agriculture (USDA)., Beltsville, MD (United States); Halkjaer-Knudsen, Vibeke [Statens Serum Inst., Copenhagen (Denmark); Prat, Esmeralda [Bayer CropScience, Monheim am Rhein (Germany)

    2010-10-01

    Laboratories that work with biological agents need to manage their safety risks to persons working the laboratories and the human and animal community in the surrounding areas. Biosafety guidance defines a wide variety of biosafety risk mitigation measures, which include measures which fall under the following categories: engineering controls, procedural and administrative controls, and the use of personal protective equipment; the determination of which mitigation measures should be used to address the specific laboratory risks are dependent upon a risk assessment. Ideally, a risk assessment should be conducted in a manner which is standardized and systematic which allows it to be repeatable and comparable. A risk assessment should clearly define the risk being assessed and avoid over complication.

  6. Offshore risk assessment

    CERN Document Server

    Vinnem, Jan-Erik

    2014-01-01

      Offshore Risk Assessment was the first book to deal with quantified risk assessment (QRA) as applied specifically to offshore installations and operations. Risk assessment techniques have been used for more than three decades in the offshore oil and gas industry, and their use is set to expand increasingly as the industry moves into new areas and faces new challenges in older regions.   This updated and expanded third edition has been informed by a major R&D program on offshore risk assessment in Norway and summarizes research from 2006 to the present day. Rooted with a thorough discussion of risk metrics and risk analysis methodology,  subsequent chapters are devoted to analytical approaches to escalation, escape, evacuation and rescue analysis of safety and emergency systems.   Separate chapters analyze the main hazards of offshore structures: fire, explosion, collision, and falling objects as well as structural and marine hazards. Risk mitigation and control are discussed, as well as an illustrat...

  7. Initial clinical validation of Health Heritage, a patient-facing tool for personal and family history collection and cancer risk assessment.

    Science.gov (United States)

    Baumgart, Leigh A; Postula, Kristen J Vogel; Knaus, William A

    2016-04-01

    Personal and family health histories remain important independent risk factors for cancer; however they are currently not being well collected or used effectively. Health Heritage was designed to address this need. The purpose of this study was to validate the ability of Health Heritage to identify patients appropriate for further genetic evaluation and to accurately stratify cancer risk. A retrospective chart review was conducted on 100 random patients seen at an adult genetics clinic presenting with concern for an inherited predisposition to cancer. Relevant personal and family history obtained from the patients' medical records was entered into Health Heritage. Recommendations by Health Heritage were compared to national guidelines of eligibility for genetic evaluation. Agreement between Health Heritage referral for genetic evaluation and guideline eligibility for genetic evaluation was 97% (sensitivity 98% and specificity 88%). Risk stratification for cancer was also compared between Health Heritage and those documented by a geneticist. For patients at increased risk for breast, ovarian, or colorectal cancer as determined by the geneticist, risk stratification by Health Heritage agreed 90, 93, and 75%, respectively. Discordances in risk stratification were attributed to both complex situations better handled by the geneticist and Health Heritage's adherence to incorporating all information into its algorithms. Health Heritage is a clinically valid tool to identify patients appropriate for further genetic evaluation and to encourage them to confirm the assessment and management recommendations with cancer genetic experts. Health Heritage also provides an estimate of cancer risk that is complementary to a genetics team.

  8. Hazards identified and the need for health risk assessment in the South African mining industry.

    Science.gov (United States)

    Utembe, W; Faustman, E M; Matatiele, P; Gulumian, M

    2015-12-01

    Although mining plays a prominent role in the economy of South Africa, it is associated with many chemical hazards. Exposure to dust from mining can lead to many pathological effects depending on mineralogical composition, size, shape and levels and duration of exposure. Mining and processing of minerals also result in occupational exposure to toxic substances such as platinum, chromium, vanadium, manganese, mercury, cyanide and diesel particulate. South Africa has set occupational exposure limits (OELs) for some hazards, but mine workers are still at a risk. Since the hazard posed by a mineral depends on its physiochemical properties, it is recommended that South Africa should not simply adopt OELs from other countries but rather set her own standards based on local toxicity studies. The limits should take into account the issue of mixtures to which workers could be exposed as well as the health status of the workers. The mining industry is also a source of contamination of the environment, due inter alia to the large areas of tailings dams and dumps left behind. Therefore, there is need to develop guidelines for safe land-uses of contaminated lands after mine closure.

  9. Dietary exposure to aluminium and health risk assessment in the residents of Shenzhen, China.

    Directory of Open Access Journals (Sweden)

    Mei Yang

    Full Text Available Although there are great changes of dietary in the past few decades in China, few are known about the aluminium exposure in Chinese diet. The aim of this study is to systematically evaluate the dietary aluminium intake level in residents of Shenzhen, China. A total of 853 persons from 244 household were investigated their diet by three days food records. Finally, 149 kinds of foods in 17 food groups were selected to be the most consumed foods. From them, 1399 food samples were collected from market to test aluminium concentration. High aluminium levels were found in jellyfish (median, 527.5 mg/kg, fried twisted cruller (median, 466.0 mg/kg, shell (median, 107.1 mg/kg. The Shenzhen residents' average dietary aluminium exposure was estimated at 1.263 mg/kg bw/week which is lower than the PTWI (provisional tolerable weekly intake. But 0-2 and 3-13 age groups have the highest aluminium intake exceeding the PTWI (3.356 mg/kg bw/week and 3.248 mg/kg bw/week than other age groups. And the main dietary aluminium exposure sources are fried twisted cruller, leaf vegetables and bean products. Our study suggested that even three decades rapid economy development, children in Shenzhen still have high dietary aluminium exposure risk. How to control high dietary aluminium exposure still is a great public health challenge in Shenzhen, China.

  10. Dietary exposure to aluminium and health risk assessment in the residents of Shenzhen, China.

    Science.gov (United States)

    Yang, Mei; Jiang, Lixin; Huang, Huiping; Zeng, Shengbo; Qiu, Fen; Yu, Miao; Li, Xiaorong; Wei, Sheng

    2014-01-01

    Although there are great changes of dietary in the past few decades in China, few are known about the aluminium exposure in Chinese diet. The aim of this study is to systematically evaluate the dietary aluminium intake level in residents of Shenzhen, China. A total of 853 persons from 244 household were investigated their diet by three days food records. Finally, 149 kinds of foods in 17 food groups were selected to be the most consumed foods. From them, 1399 food samples were collected from market to test aluminium concentration. High aluminium levels were found in jellyfish (median, 527.5 mg/kg), fried twisted cruller (median, 466.0 mg/kg), shell (median, 107.1 mg/kg). The Shenzhen residents' average dietary aluminium exposure was estimated at 1.263 mg/kg bw/week which is lower than the PTWI (provisional tolerable weekly intake). But 0-2 and 3-13 age groups have the highest aluminium intake exceeding the PTWI (3.356 mg/kg bw/week and 3.248 mg/kg bw/week) than other age groups. And the main dietary aluminium exposure sources are fried twisted cruller, leaf vegetables and bean products. Our study suggested that even three decades rapid economy development, children in Shenzhen still have high dietary aluminium exposure risk. How to control high dietary aluminium exposure still is a great public health challenge in Shenzhen, China.

  11. An exploration of spatial human health risk assessment of soil toxic metals under different land uses using sequential indicator simulation.

    Science.gov (United States)

    Huang, Jin-Hui; Liu, Wen-Chu; Zeng, Guang-Ming; Li, Fei; Huang, Xiao-Long; Gu, Yan-Ling; Shi, Li-Xiu; Shi, Ya-Hui; Wan, Jia

    2016-07-01

    A modified method was proposed which integrates the spatial patterns of toxic metals simulated by sequential indicator simulation, different exposure models and local current land uses extracted by remote-sensing software into a dose-response model for human health risk assessment of toxic metals. A total of 156 soil samples with a various land uses containing farm land (F1-F25), forest land (W1-W12) and residential land (U1-U15) were collected in a grid pattern throughout Xiandao District (XDD), Hunan Province, China. The total Cr and Pb in topsoil were analyzed. Compared with Hunan soil background values, the elevated concentrations of Cr were mainly located in the east of XDD, and the elevated concentrations of Pb were scattered in the areas around F1, F6, F8, F13, F14, U5, U14, W2 and W11. For non-carcinogenic effects, the hazard index (HI) of Cr and Pb overall the XDD did not exceed the accepted level to adults. While to children, Cr and Pb exhibited HI higher than the accepted level around some areas. The assessment results indicated Cr and Pb should be regarded as the priority pollutants of concern in XDD. The first priority areas of concern were identified in region A with a high probability (>0.95) of risk in excess of the accepted level for Cr and Pb. The areas with probability of risk between 0.85 and 0.95 in region A were identified to be the secondary priority areas for Cr and Pb. The modified method was proved useful due to its improvement on previous studies and calculating a more realistic human health risk, thus reducing the probability of excessive environmental management.

  12. Distribution, possible sources, and health risk assessment of SVOC pollution in small streams in Pearl River Delta, China.

    Science.gov (United States)

    Sun, Hongwei; An, Taicheng; Li, Guiying; Qiao, Meng; Wei, Dongbin

    2014-09-01

    The pollution levels of typical semivolatile organic compounds (SVOCs) consisting of 15 polycyclic aromatic hydrocarbons (PAHs), 20 organic chlorinated pesticides (OCPs), and 15 phthalate esters (PAEs) were investigated in small rivers running through the flourishing cities in Pearl River Delta region, China. The concentrations of ∑15PAHs were 2.0-48 ng/L and 29-1.2 × 10(3) ng/g in the water and sediment samples, respectively. The ∑20OCPs were 6.6-57 ng/L and 9.3-6.0 × 10(2) ng/g in the water and sediment samples, respectively. The concentrations of ∑15PAEs were much higher both in the water and sediments. The partition process of the detected SVOCs between the water and sediment did not reach the equilibrium state at most of the sites when sampling. The combustion of petroleum products and coal was the major source of the detected PAHs. The OCPs were mainly historical residue, whereas the new inputs of dichlorodiphenyltrichloroethane (DDT), chlordane, and endosulfan were possible at several sites. The industrial and domestic sewage were the major source for the PAEs; storm water runoff accelerated the input of PAEs. No chronic risk of the SVOCs was identified by a health risk assessment through daily water consumption, except for the ∑20OCPs that might cause cancer at several sites. Nevertheless, the integrated health risk of the SVOCs should not be neglected and need intensive investigations.

  13. Origin and assessment of groundwater pollution and associated health risk: a case study in an industrial park, northwest China.

    Science.gov (United States)

    Li, Peiyue; Wu, Jianhua; Qian, Hui; Lyu, Xinsheng; Liu, Hongwei

    2014-08-01

    Groundwater quality which relates closely to human health has become as important as its quantity due to the demand for safe water. In the present study, an entropy-weighted fuzzy water quality index (WQI) has been proposed for performing groundwater quality assessment in and around an industrial park, northwest China, where domestic water requirements are solely met by groundwater. The human health risk was assessed with the model recommended by the United States Environmental Protection Agency. In addition, the sources of major ions and main contaminants were also analyzed. The study shows that groundwater in the study area has been contaminated conjunctively by natural processes and industrial and agricultural activities. Nitrate, manganese (Mn), fluoride, total dissolved solids, total hardness and sulfate are major contaminants influencing groundwater quality. Nitrate and heavy metals such as Mn are mainly affected by human agricultural activities and industrial production, while other contaminants are mainly originated from mineral weathering and water-rock interactions. The results of water quality assessment suggest that half of the groundwater samples collected are of medium quality thus require pretreatment before human consumption. The mean health risk caused by the consumption of contaminated groundwater in the area is 8.42 × 10(-5) per year which surpasses the maximum acceptable level (5 × 10(-5) per year) recommended by the International Commission on Radiologic Protection. The entropy-weighted fuzzy WQI proposed in this study can not only assign proper weights to parameters but also treat uncertainties associated with water quality classification. This study will be of interest to international environmentalists and hydrogeologists. It will also be useful in regional groundwater management and protection.

  14. Health risk assessment of heavy metals in soils and vegetables from wastewater irrigated area, Beijing-Tianjin city cluster, China

    Institute of Scientific and Technical Information of China (English)

    Yanchun Wang; Min Qiao; Yunxia Liu; Yongguan Zhu

    2012-01-01

    The possible health risks of heavy metals contamination to local population through food chain were evaluated in Beijing and Tianjin city cluster,China,where have a long history of sewage irrigation.The transfer factors (TF) for heavy metals from soil to vegetables for six elements including Cu,Zn,Pb,Cr,As and Cd were calculated and the pollution load indexes (PLI) were also assessed.Results indicate that only Cd exceeded the maximum acceptable limit in these sites.So far,the heavy metal concentrations in soils and vegetables were all below the permissible limits set by the Ministry of Environmental Protection of China and World Health Organization.The transfer factors of six heavy metals showed the trend as Cd > Zn > Cu > Pb > As > Cr,which were dependent on the vegetable species.The estimated dietary intakes of Cu,Zn,Pb,Cr,As and Cd were far below the tolerable limits and the target hazard quotient (THQ) values were less than 1,which suggested that the health risks of heavy metals exposure through consuming vegetables were generally assumed to be safe.

  15. Ultraviolet Radiation: Human Exposure and Health Risks.

    Science.gov (United States)

    Tenkate, Thomas D.

    1998-01-01

    Provides an overview of human exposure to ultraviolet radiation and associated health effects as well as risk estimates for acute and chronic conditions resulting from such exposure. Demonstrates substantial reductions in health risk that can be achieved through preventive actions. Also includes a risk assessment model for skin cancer. Contains 36…

  16. Approaches to advancing quantitative human health risk assessment of environmental chemicals in the post-genomic era

    Energy Technology Data Exchange (ETDEWEB)

    Chiu, Weihsueh A., E-mail: chiu.weihsueh@epa.gov [National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington DC, 20460 (United States); Euling, Susan Y.; Scott, Cheryl Siegel; Subramaniam, Ravi P. [National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington DC, 20460 (United States)

    2013-09-15

    The contribution of genomics and associated technologies to human health risk assessment for environmental chemicals has focused largely on elucidating mechanisms of toxicity, as discussed in other articles in this issue. However, there is interest in moving beyond hazard characterization to making more direct impacts on quantitative risk assessment (QRA) — i.e., the determination of toxicity values for setting exposure standards and cleanup values. We propose that the evolution of QRA of environmental chemicals in the post-genomic era will involve three, somewhat overlapping phases in which different types of approaches begin to mature. The initial focus (in Phase I) has been and continues to be on “augmentation” of weight of evidence — using genomic and related technologies qualitatively to increase the confidence in and scientific basis of the results of QRA. Efforts aimed towards “integration” of these data with traditional animal-based approaches, in particular quantitative predictors, or surrogates, for the in vivo toxicity data to which they have been anchored are just beginning to be explored now (in Phase II). In parallel, there is a recognized need for “expansion” of the use of established biomarkers of susceptibility or risk of human diseases and disorders for QRA, particularly for addressing the issues of cumulative assessment and population risk. Ultimately (in Phase III), substantial further advances could be realized by the development of novel molecular and pathway-based biomarkers and statistical and in silico models that build on anticipated progress in understanding the pathways of human diseases and disorders. Such efforts would facilitate a gradual “reorientation” of QRA towards approaches that more directly link environmental exposures to human outcomes.

  17. Monitoring of cotton dust and health risk assessment in small-scale weaving industry.

    Science.gov (United States)

    Tahir, Muhammad Wajid; Mumtaz, Muhammad Waseem; Tauseef, Shanza; Sajjad, Muqadas; Nazeer, Awais; Farheen, Nazish; Iqbal, Muddsar

    2012-08-01

    The present study describes the estimation of particulate matter (cotton dust) with different sizes, i.e., PM(1.0), PM(2.5), PM(4.0), and PM(10.0 μm) in small-scale weaving industry (power looms) situated in district Hafizabad, Punjab, Pakistan, and the assessment of health problems of workers associated with these pollutants. A significant difference was found in PM(1.0), PM(2.5), PM(4.0), and PM(10.0) with reference to nine different sampling stations with p values 4.0), and PM(10.0), depict that PM(1.0) differs significantly from PM(2.5), PM(4.0), and PM(10.0), with p values 4.0), with a p value >0.05 in defined sampling stations on an average basis. Majority of the workers were facing several diseases due to interaction with particulate matter (cotton dust) during working hours. Flue, cough, eye, and skin infections were the most common diseases among workers caused by particulate matter (cotton dust).

  18. Health and environmental risk assessment associated with a potential recovery of the Russian submarine K-27

    Energy Technology Data Exchange (ETDEWEB)

    Hosseini, A.; Amundsen, I.; Brown, J.E.; Dowdall, M.; Standring, W. [Norwegian Radiation Protection Authority/CERAD CoE (Norway); Bartnicki, J. [Norwegian Meteorological Institute/CERAD CoE (Norway); Karcher, M. [O.A.Sys - Ocean Atmosphere Systems GmbH (Germany); Lind, O.C.; Salbu, B. [Norwegian University of Life Sciences/CERAD CoE (Norway)

    2014-07-01

    terrestrial ecosystems. The modelling will provide information of the spatial and temporal distribution of the activity concentrations in water and / air of various radionuclides as a function of the source term (activity released). The outputs from these dispersion models will act as inputs to food-chain transfer and environmental dosimetry models such as ERICA and other well developed pathways-based type of models for the environment and health assessment. The paper will provide an overview of this study along with presenting the main results achieved. (authors)

  19. Heavy metal content in vegetables and fruits cultivated in Baia Mare mining area (Romania) and health risk assessment.

    Science.gov (United States)

    Roba, Carmen; Roşu, Cristina; Piştea, Ioana; Ozunu, Alexandru; Baciu, Călin

    2016-04-01

    Information about heavy metal concentrations in food products and their dietary intake are essential for assessing the health risk of local inhabitants. The main purposes of the present study were (1) to investigate the concentrations of Zn, Cu, Pb, and Cd in several vegetables and fruits cultivated in Baia Mare mining area (Romania); (2) to assess the human health risk associated with the ingestion of contaminated vegetables and fruits by calculating the daily intake rate (DIR) and the target hazard quotient (THQ); and (3) to establish some recommendations on human diet in order to assure an improvement in food safety. The concentration order of heavy metals in the analyzed vegetable and fruit samples was Zn > Cu > Pb > Cd. The results showed the heavy metals are more likely to accumulate in vegetables (10.8-630.6 mg/kg dw for Zn, 1.4-196.6 mg/kg dw for Cu, 0.2-155.7 mg/kg dw for Pb, and 0.03-6.61 mg/kg dw for Cd) than in fruits (4.9-55.9 mg/kg dw for Zn, 1.9-24.7 mg/kg dw for Cu, 0.04-8.82 mg/kg dw for Pb, and 0.01-0.81 mg/kg dw for Cd). Parsley, kohlrabi, and lettuce proved to be high heavy metal accumulators. By calculating DIR and THQ, the data indicated that consumption of parsley, kohlrabi, and lettuce from the area on a regular basis may pose high potential health risks to local inhabitants, especially in the area located close to non-ferrous metallurgical plants (Romplumb SA and Cuprom SA) and close to Tăuții de Sus tailings ponds. The DIR for Zn (85.3-231.6 μg/day kg body weight) and Cu (25.0-44.6 μg/day kg body weight) were higher in rural areas, while for Pb (0.6-3.1 μg/day kg body weight) and Cd (0.22-0.82 μg/day kg body weight), the DIR were higher in urban areas, close to the non-ferrous metallurgical plants SC Romplumb SA and SC Cuprom SA. The THQ for Zn, Cu, Pb, and Cd was higher than 5 for health risks.

  20. Validation of self-reported maternal and infant health indicators in the Pregnancy Risk Assessment Monitoring System.

    Science.gov (United States)

    Dietz, Patricia; Bombard, Jennifer; Mulready-Ward, Candace; Gauthier, John; Sackoff, Judith; Brozicevic, Peggy; Gambatese, Melissa; Nyland-Funke, Michael; England, Lucinda; Harrison, Leslie; Taylor, Allan

    2014-12-01

    To assess the validity of self-reported maternal and infant health indicators reported by mothers an average of 4 months after delivery. Three validity measures-sensitivity, specificity and positive predictive value (PPV)-were calculated for pregnancy history, pregnancy complications, health care utilization, and infant health indicators self-reported on the Pregnancy Risk Assessment Monitoring System (PRAMS) questionnaire by a representative sample of mothers delivering live births in New York City (NYC) (n = 603) and Vermont (n = 664) in 2009. Data abstracted from hospital records served as gold standards. All data were weighted to be representative of women delivering live births in NYC or Vermont during the study period. Most PRAMS indicators had >90 % specificity. Indicators with >90 % sensitivity and PPV for both sites included prior live birth, any diabetes, and Medicaid insurance at delivery, and for Vermont only, infant admission to the NICU and breastfeeding in the hospital. Indicators with poor sensitivity and PPV (urinary tract infection or kidney infection, and for NYC only, preterm labor, prior low-birth-weight birth, and prior preterm birth. For Vermont only, receipt of an HIV test during pregnancy had poor sensitivity and PPV. Mothers accurately reported information on prior live births and Medicaid insurance at delivery; however, mothers' recall of certain pregnancy complications and pregnancy history was poor. These findings could be used to prioritize data collection of indicators with high validity.

  1. Heavy metals in road dust from Xiandao District, Changsha City, China: characteristics, health risk assessment, and integrated source identification.

    Science.gov (United States)

    Li, Fei; Zhang, Jingdong; Huang, Jinhui; Huang, Dawei; Yang, Jun; Song, Yongwei; Zeng, Guangming

    2016-07-01

    The physicochemical properties and the contents of metals (Cu, Zn, Pb, Cd, Cr, and Fe) in 51 road dust samples from Xiandao District (XDD) were investigated. Enrichment factor (EF), multivariate statistics, geostatistics, and health risk assessment model were adopted to study the spatial pollution pattern and to identify the priority pollutants and regions of concern and sources of studied metals. The mean EFs revealed the following order: Cd > Zn ≈ Pb ≈ Cu > Cr. For non-carcinogenic effects, the exposure pathway which resulted in the highest levels of exposure risk for children and adults was ingestion, followed by dermal contact and inhalation. Hazard index (HI) values for the studied metals at each site were within the safe level of 1 except maximum HI Cr (1.08) for children. The carcinogenic risk (CR) for Cd and Cr at each site was within the acceptable risk level (1E-06) except CR Cr (1.08E-06) for children in the road intersection between the Changchang highway and the Yuelin highway. Cr was identified as the priority pollutant followed by Pb and Cd with consideration of the local population distribution. Spatially, northwest and northeast of XDD were regarded as the priority regions of concern. Results based on the proposed integrated source identification method indicated that Pb was probably sourced from traffic-related sources, Cd was associated with the dust organic material mainly originated from industrial sources, and Cr was mainly derived from both sources.

  2. Using risk analysis in Health Impact Assessment: the impact of different relative risks for men and women in different socio-economic groups.

    Science.gov (United States)

    Nilunger, Louise; Diderichsen, Finn; Burström, Bo; Ostlin, Piroska

    2004-02-01

    The aim of this study is to contribute to the emerging field of quantification of Health Impact Assessment (HIA), by analysing how different relative risks affect the burden of disease for various socio-economic groups (SES). Risk analysis, utilising attributable and impact fraction, raises several methodological considerations. The present study illustrates this by measuring the impact of changed distribution levels of smoking on lung cancer, ischemic heart disease (IHD), chronic obstructive lung disorder (COLD) and stroke for the highest and lowest socio-economic groups measured in disability adjusted life years (DALY). The material is based on relative risks obtained from various international studies, smoking prevalence (SP) data and the number of DALY based on data available for Sweden. The results show that if smoking would have been eliminated (attributable fraction, AF), the inequality between the highest and lowest socio-economic groups may decrease by 75% or increase by 21% depending on the size of the relative risk. Assuming the same smoking prevalence for the lowest socio-economic group as for the highest (impact fraction), then the inequality may decrease by 7-26%. Consequently, the size of the relative risk used may have a significant impact, leading to substantial biases and therefore should be taken into serious consideration in HIA.

  3. Cumulative health risk assessment of co-occurring mycotoxins of deoxynivalenol and its acetyl derivatives in wheat and maize: case study, Shanghai, China.

    Science.gov (United States)

    Han, Zheng; Nie, Dongxia; Ediage, Emmanuel Njumbe; Yang, Xianli; Wang, Jianhua; Chen, Bo; Li, Shuguang; On, Stephen L W; De Saeger, Sarah; Wu, Aibo

    2014-12-01

    Humans are naturally and frequently exposed to a multitude of mycotoxins, but health risk assessments are usually performed on individual mycotoxins, which may underestimate the total risks. In this study, we assessed for the first time the cumulative health risks of concomitant exposure via dietary intake (DI) to multiple mycotoxins, namely deoxynivalenol (DON) and its acetyl derivatives of 3-acetyldeoxynivalenol (3-ADON) and 15-acetyldeoxynivalenol (15-ADON), based on the concentration addition (CA) concept. A cross-sectional study was conducted in seven districts in Shanghai, China with 1269 participants and 330 wheat and maize samples analyzed. After probabilistic analysis using Monte Carlo simulation, the results showed no health risks to the population in Shanghai considering individual mycotoxins. However, if the cumulative health risks were calculated based on the combined consideration of DON with either 3-ADON or 15-ADON or both, the DI values in 95th percentile were up to 1087 ng/kg body weight/day, exceeding the Provisional Maximum Tolerable Daily Intake (PMTDI) of 1000 ng/kg body weight/day and hence representing potential health risks to the population in Shanghai. The integrated study proposed here could be a model strategy for cumulative health risk assessment on the co-occurring hazards in the fields of food safety combined with environmental contaminants.

  4. Health Risk Assessment of Pesticide Usage in Menia El-Kamh Province of Sharkia Governorate in Egypt

    Directory of Open Access Journals (Sweden)

    Jean-Claude Assad

    2002-10-01

    Full Text Available Abstract: Menia El-Kamh province of the Sharkia Governorate constitutes one of the largest agricultural areas in Egypt. About 88% of the nearly 472,000 people living in this province rely on agricultural activities for subsistence. Several pesticides including organochloride, organophosphorus, carbamate, and pyrethroid insecticides, fungicides, and herbicides are commonly used in citrus, vegetable and other crop-growing areas to increase agricultural productivity. However, their use has also been associated with several cases of pesticide poisoning. In this research, we conducted a field survey to assess the knowledge, attitudes, and practices of the farmer’s community regarding the safe use of pesticides. We also evaluated the residual concentrations of selected pesticides in water, soil, milk, fish, and orange samples, and estimated the potential health risks associated with the exposure to these pesticides. Data obtained from the field survey indicate that more than 95% of farm workers do not practice safety precautions during pesticide formulation and application; leading to a considerable prevalence of pesticide-related illnesses in this agricultural community. Pesticide residues in various environmental samples varied greatly; from below detection levels (3-5 ng to as high as 325 ppb depending on the matrix of interest, and the specific pesticide of concern. The analysis of health risk estimates indicated that chlorpyrifos, DDT, dimethoate, methomyl, and larvin did not pose a direct hazard to human health, although present in water, milk, orange, and/or fish. However, aldicarb, and carbosulfan levels exceeded the reference doses, indicating a great potential for systemic toxicity, especially in children who are considered to be the most vulnerable population subgroup. The upper-bound values of cancer risk from DDT exposure were estimated to be about 8 (adults, and 55 (children excess cancers in a population of one million.

  5. Are seasonal correction factors useful in assessing the health risk from domestic radon

    Energy Technology Data Exchange (ETDEWEB)

    Denman, A.R.; Groves-Kirkby, C.J. [Northampton General Hospital, Medical Physics Dept. (United Kingdom); Crockett, R.G.M.; Phillips, P.S.; Woolridge, A.C. [Northampton Univ., School of Applied Sciences (United Kingdom); Gillmore, G.K. [Bradford Univ., School of Archaeological, Geographical and Environmental Sciences (United Kingdom)

    2006-07-01

    Following an intensive survey of domestic radon levels in the UK, the former National Radiological Protection Board (N.R.P.B.), now the Radiation Protection Division of the Health Protection Agency (H.P.A.-R.P.D.) established a measurement protocol and promulgated a set of Seasonal Correction Factors (S.C.F.) applicable to the United Kingdom as a whole. Radon levels are assumed to exhibit systematic repeatable annual variation, generally higher in winter than in summer, and the S.C.F. comprise numerical multipliers which convert a one-month oree-month radon measurement, commencing in any month of the year, to an effective annual mean radon concentration. In a recent project to assess the utility of short-term exposures in quantifying domestic radon levels, radon variability in a set of 34 houses on common radon-rich geology was found to depart significantly from that predicted by the H.P.A.-R.P.D. seasonal correction factors, with year-end discontinuities at both 1-month and 3- month measurement resolutions. Following this study, monitoring with electrets was continued in four properties, with weekly radon concentration data now available for a total duration of three years. Analysis of this data has permitted the derivation of reliable local seasonal correction factors. Overall, these are significantly lower than those recommended by H.P.A.-R.P.D., but are comparable with other results from the UK and from abroad, particularly those that recognise geological diversity and are consequently prepared on a regional rather than a national basis. The discussion calls into question the validity of using nationally aggregated factors, especially for shorter exposures. (authors)

  6. Uncertainty in environmental health risk assessment: a framework for analysis and an application to a chronic exposure situation involving a chemical carcinogen

    Energy Technology Data Exchange (ETDEWEB)

    Bogen, K.T.

    1986-01-01

    The impact of uncertainty and inter-individual variability is not rigorously addressed in current environmental health risk assessments performed for regulatory purposes. The availability of such information on a systematic basis would not only serve to clarify technical assumptions underlying risk assessment, but would also greatly facilitate the application of more-sophisticated quantitative approaches to risk management decision making. Here, focusing on the particular context of regulatory risk assessment for chemical carcinogens, a taxonomy of uncertainty and variability in the elements of risk assessment is developed, potential generic sources are reviewed and a critical overview of some current approaches to incorporating uncertainty and variability into risk assessment is offered. The general problems of compounded uncertainty and creeping safety - regarding the degree to which uncertainty or safety assumed in each component of a risk assessment may be compounded or magnified in a final risk prediction - are described. A formal methodology is developed for qualitative uncertainty analysis, i.e., the quantitative analysis of the impact that modeled uncertainty and/or variability in each component of a risk assessment has on uncertainty and variability in final predicted risk.

  7. Assessing potential health risks to fish and humans using mercury concentrations in inland fish from across western Canada and the United States

    Science.gov (United States)

    Lepak, Jesse M; Hooten, Mevin B.; Eagles-Smith, Collin A.; Tate, Michael T.; Lutz, Michelle A.; Ackerman, Joshua T.; Willacker, James J.; Jackson, Allyson K.; Evers, David C.; Wiener, James G.; Pritz, Colleen Flanagan; Davis, Jay

    2016-01-01

    Fish represent high quality protein and nutrient sources, but Hg contamination is ubiquitous in aquatic ecosystems and can pose health risks to fish and their consumers. Potential health risks posed to fish and humans by Hg contamination in fish were assessed in western Canada and the United States. A large compilation of inland fish Hg concentrations was evaluated in terms of potential health risk to the fish themselves, health risk to predatory fish that consume Hg contaminated fish, and to humans that consume Hg contaminated fish. The probability that a fish collected from a given location would exceed a Hg concentration benchmark relevant to a health risk was calculated. These exceedance probabilities and their associated uncertainties were characterized for fish of multiple size classes at multiple health-relevant benchmarks. The approach was novel and allowed for the assessment of the potential for deleterious health effects in fish and humans associated with Hg contamination in fish across this broad study area. Exceedance probabilities were relatively common at low Hg concentration benchmarks, particularly for fish in larger size classes. Specifically, median exceedances for the largest size classes of fish evaluated at the lowest Hg concentration benchmarks were 0.73 (potential health risks to fish themselves), 0.90 (potential health risk to predatory fish that consume Hg contaminated fish), and 0.97 (potential for restricted fish consumption by humans), but diminished to essentially zero at the highest benchmarks and smallest fish size classes. Exceedances of benchmarks are likely to have deleterious health effects on fish and limit recommended amounts of fish humans consume in western Canada and the United States. Results presented here are not intended to subvert or replace local fish Hg data or consumption advice, but provide a basis for identifying areas of potential health risk and developing more focused future research and monitoring efforts.

  8. Uncertainties in risk assessment at USDOE facilities

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, L.D.; Holtzman, S.; Meinhold, A.F.; Morris, S.C.; Rowe, M.D.

    1994-01-01

    The United States Department of Energy (USDOE) has embarked on an ambitious program to remediate environmental contamination at its facilities. Decisions concerning cleanup goals, choices among cleanup technologies, and funding prioritization should be largely risk-based. Risk assessments will be used more extensively by the USDOE in the future. USDOE needs to develop and refine risk assessment methods and fund research to reduce major sources of uncertainty in risk assessments at USDOE facilities. The terms{open_quote} risk assessment{close_quote} and{open_quote} risk management{close_quote} are frequently confused. The National Research Council (1983) and the United States Environmental Protection Agency (USEPA, 1991a) described risk assessment as a scientific process that contributes to risk management. Risk assessment is the process of collecting, analyzing and integrating data and information to identify hazards, assess exposures and dose responses, and characterize risks. Risk characterization must include a clear presentation of {open_quotes}... the most significant data and uncertainties...{close_quotes} in an assessment. Significant data and uncertainties are {open_quotes}...those that define and explain the main risk conclusions{close_quotes}. Risk management integrates risk assessment information with other considerations, such as risk perceptions, socioeconomic and political factors, and statutes, to make and justify decisions. Risk assessments, as scientific processes, should be made independently of the other aspects of risk management (USEPA, 1991a), but current methods for assessing health risks are based on conservative regulatory principles, causing unnecessary public concern and misallocation of funds for remediation.

  9. [Residues and health risk assessment of sulfonamides in sediment and fish from typical marine aquaculture regions of Guangdong Province, China].

    Science.gov (United States)

    He, Xiu-Ting; Wang, Qi; Nie, Xiang-Ping; Yang, Yong-Tao; Cheng, Zhang

    2014-07-01

    Concentrations of sulfonamides including sulfadiazine (SDZ), sulfadimidin (SM2) and sulfamethoxazole (SMX) in sediments, muscle and liver tissues of 7 kinds of fish species collected from two marine aquaculture regions along the coast of Guangdong Provice were determined by high performance liquid chromatography (HPLC) equipped with a ultraviolet detector. Assessment of the health risks were conducted based on the values of maximum residue limits (MRL) and acceptable daily intake (ADI). The results showed that sulfonamides were found in all the sediment samples. The concentrations (dry wet) ranged from 2.1 - 35.2 ng x g(-1), the detected frequency of the 3 sulfonamide antibiotics ranked as SDZ (85.7%) > SM2 (71.4%) > SMX (28.6%). The detection rate of sulfonamides in samples from Daya Bay was higher than that from Hailing Island. Higher concentrations were detected in liver tissues rather than in muscle tissues (P < 0.05). The residues of SDZ, SM2 and SMX in fish muscle tissues (wet weight) ranged from 11.6-37.9, 16.3-27.8 and 4.9-20.0 ng x g(-1), respectively. The calculated daily intakes of sulfonamides in the present study ranged from 3.37-36.72 ng x kg(-1), which accounted for 0.007% -0.073% of the ADI (50 microg x kg(-1)). Health risks to human body were negligible as the estimated intake was less than 1% ADI, therefore the security of dietary was high.

  10. Estimate of dietary intake of chloropropanols (3-MCPD and 1,3-DCP and health risk assessment

    Directory of Open Access Journals (Sweden)

    Adriana Pavesi Arisseto

    2013-02-01

    Full Text Available Chloropropanols, including 3-monochloropropane-1,2-diol (3-MCPD and 1,3-dichloropropan-2-ol (1,3-DCP, comprise a group of chemical contaminants with carcinogenic and genotoxic properties. They have been found in a variety of processed foods and food ingredients, such as hydrolyzed vegetable protein, soy sauce, cereal-based products, malt-derived ingredients, and smoked foods. This study aimed to assess the dietary exposure to 3-MCPD and 1,3-DCP in Brazil and verify whether the presence of these substances in foods could represent health risks. The intake was calculated by combining data on food consumption, provided by the Consumer Expenditure Survey 2008-2009, with the levels of contaminant occurrence determined by gas chromatography-mass spectrometry. The exposure to 3-MCPD ranged from 0.06 to 0.51 µg.kg bw-1.day-1 considering average and high consumers, while the intake of 1,3-DCP was estimated to be 0.0036 µg.kg bw-1.day-1 in the worst case scenario evaluated. Based on these results, it was verified that the Brazilians' exposure to chloropropanols does not present a significant health risk. However, the consumption of specific foods containing high levels of 3-MCPD could exceed the provisional maximum tolerable daily intake of 2 µg.kg bw-1 established for this compound and, therefore, represent a potential concern.

  11. Landslide risk assessment

    Science.gov (United States)

    Lessing, P.; Messina, C.P.; Fonner, R.F.

    1983-01-01

    Landslide risk can be assessed by evaluating geological conditions associated with past events. A sample of 2,4 16 slides from urban areas in West Virginia, each with 12 associated geological factors, has been analyzed using SAS computer methods. In addition, selected data have been normalized to account for areal distribution of rock formations, soil series, and slope percents. Final calculations yield landslide risk assessments of 1.50=high risk. The simplicity of the method provides for a rapid, initial assessment prior to financial investment. However, it does not replace on-site investigations, nor excuse poor construction. ?? 1983 Springer-Verlag New York Inc.

  12. Patient caries risk assessment

    DEFF Research Database (Denmark)

    Twetman, Svante; Fontana, Margherita

    2009-01-01

    Risk assessment is an essential component in the decision-making process for the correct prevention and management of dental caries. Multiple risk factors and indicators have been proposed as targets in the assessment of risk of future disease, varying sometimes based on the age group at which...... for prediction purposes, as measured until now in the literature, is at best questionable in schoolchildren, adolescents and adults. That is not to say these additional factors should not be assessed to help understand the strength of their associations with the disease experience in a particular patient......, and aid in the development of an individualized and targeted preventive and management plan....

  13. Health risk assessment and applied action level of toluene. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Reed, N.R.; Reed, W.A.; Weir, K.; Encomienda, I.; Beltran, L.M.

    1989-05-16

    The purpose of the document is to provide information on the toxicity of toluene and to estimate Applied Action Levels (AALs) for toluene in water, air, and soil. The information provided will aid the California Dept. of Health Services manage hazardous waste sites and protect the health of California residents.

  14. Pollution level and human health risk assessment of some pesticides and polychlorinated biphenyls in Nantong of Southeast China

    Institute of Scientific and Technical Information of China (English)

    Na Wang; Li Yi; Lili Shi; Deyang Kong; Daoji Cai; Donghua Wang; Zhengjun Shan

    2012-01-01

    Food consumption is one of the key exposure routes of humans to contaminants.This article evaluated the residue levels of 51 pesticides and 16 polychlorinated biphenyls (PCBs) in selected fish and food items which were commonly consumed in the Nantong area of Jiangsu Province,Southeast China.The 51 pesticides and 16 PCBs were analyzed by highly sensitive gas chromatographytandem mass spectrometry (GC-MS/MS).The results showed that organochlorine pesticides such as dichlorodiphenyltrichloroethanes (DDTs),hexachlorocyclohexanes (HCHs),hexachlorobenzene (HCB) and mirex and other pesticides including chlorpyrifos,pyrethroid pesticides,metolachlor,pyridaben and trifluralin were frequently detected in the samples,which was consistent with the accumulation level and characteristics of these toxic chemicals in human adipose tissue of people living in Nantong.Meanwhile,correlation of the residue level of toxic chemicals with their physical chemical properties and historic use pattern in Nantong area was observed.Combined with dietary survey results at the same sampling locations,human health risk assessment of ingestion through the dietary route was performed.The results suggested that the non-cancer risks of the chemicals investigated can be considered negligible in the Nantong area,however,the cancer risks from lifetime dietary exposure to DDTs and HCB have exceeded the acceptable levels.

  15. Systemic Approach for Health Risk Assessment of Ambient Air Concentrations of Benzene in Petrochemical Environments: Integration of Fuzzy Logic, Artificial Neural Network, and IRIS Toxicity Method

    OpenAIRE

    Vahid NOVIN; Givehchi, Saeed; HOVEIDI, Hassan

    2016-01-01

    Background: Reliable methods are crucial to cope with uncertainties in the risk analysis process. The aim of this study is to develop an integrated approach to assessing risks of benzene in the petrochemical plant that produces benzene. We offer an integrated system to contribute imprecise variables into the health risk calculation.Methods: The project was conducted in Asaluyeh, southern Iran during the years from 2013 to 2014. Integrated method includes fuzzy logic and artificial neural netw...

  16. Exploring the Life Expectancy Increase in Poland in the Context of CVD Mortality Fall: The Risk Assessment Bottom-Up Approach, From Health Outcome to Policies.

    Science.gov (United States)

    Kobza, Joanna; Geremek, Mariusz

    2015-01-01

    Life expectancy at birth is considered the best mortality-based summary indicator of the health status of the population and is useful for measuring long-term health changes. The objective of this article was to present the concept of the bottom-up policy risk assessment approach, developed to identify challenges involved in analyzing risk factor reduction policies and in assessing how the related health indicators have changed over time. This article focuses on the reasons of the significant life expectancy prolongation in Poland over the past 2 decades, thus includes policy context. The methodology details a bottom-up risk assessment approach, a chain of relations between the health outcome, risk factors, and health policy, based on Risk Assessment From Policy to Impact Dimension project guidance. A decline in cardiovascular disease mortality was a key factor that followed life expectancy prolongation. Among basic factors, tobacco and alcohol consumption, diet, physical activity, and new treatment technologies were identified. Poor health outcomes of the Polish population at the beginning of 1990s highlighted the need of the implementation of various health promotion programs, legal acts, and more effective public health policies. Evidence-based public health policy needs translating scientific research into policy and practice. The bottom-up case study template can be one of the focal tools in this process. Accountability for the health impact of policies and programs and legitimization of the decisions of policy makers has become one of the key questions nowadays in European countries' decision-making process and in EU public health strategy.

  17. Potential for Incorporation of Genetic Polymorphism Data in Human Health Risk Assessment

    Science.gov (United States)

    This overview summarizes several EPA assessment publications evaluating the potential impact of genetic polymorphisms in ten metabolizing enzymes on the variability in enzyme function across ethnically diverse populations.

  18. Adenovirus-associated health risks for recreational activities in a multi-use coastal watershed based on site-specific quantitative microbial risk assessment.

    Science.gov (United States)

    Kundu, Arti; McBride, Graham; Wuertz, Stefan

    2013-10-15

    We used site-specific quantitative microbial risk assessment (QMRA) to assess the probability of adenovirus illness for three groups of swimmers: adults with primary contact, children with primary contact, and secondary contact regardless of age. Human enteroviruses and adenoviruses were monitored by qPCR in a multi-use watershed and Adenovirus type 40/41 was detected in 11% of 73 samples, ranging from 147 to 4117 genomes per liter. Enterovirus was detected only once (32 genomes per liter). Seven of eight virus detections occurred when E. coli concentrations were below the single sample maximum water quality criterion for contact recreation, and five of eight virus detections occurred when fecal coliforms were below the corresponding criterion. We employed dose-harmonization to convert viral genome measurements to TCID50 values needed for dose-response curves. The three scenarios considered different amounts of water ingestion and Monte Carlo simulation was used to account for the variability associated with the doses. The mean illness risk in children based on adenovirus measurements obtained over 11 months was estimated to be 3.5%, which is below the 3.6% risk considered tolerable by the current United States EPA recreational criteria for gastrointestinal illnesses (GI). The mean risks of GI illness for adults and secondary contact were 1.9% and 1.0%, respectively. These risks changed appreciably when different distributions were fitted to the data as determined by Monte Carlo simulations. In general, risk was at a maximum for the log-logistic distribution and lowest for the hockey stick distribution in all three selected scenarios. Also, under default assumptions, the risk was lowered considerably when assuming that only a small proportion of Adenovirus 40/41 (3%) was as infectious as Adenovirus type 4, compared to the assumption that all genomes were Adenovirus 4. In conclusion, site-specific QMRA on water-borne adenoviruses in this watershed provided a similar

  19. VA telemental health: suicide assessment.

    Science.gov (United States)

    Godleski, Linda; Nieves, J Edwin; Darkins, Adam; Lehmann, Laurent

    2008-01-01

    The Department of Veterans Affairs (VA) encompasses one of the largest telemental health networks in the world, with over 45,000 videoconferencing and over 5,000 home telemental health encounters annually. Recently, the VA designated suicide prevention as a major priority, with telehealth modalities providing opportunities for remote interventions. Suicide risk assessments, using videoconferencing, are now documented in the literature, as are current studies that find telemental health to be equivalent to face-to-face treatment. Remote assessment of suicidality, however, involves complex legal issues: licensing requirements for remote delivery of care, legal procedures for involuntary detainment and commitment of potentially harmful patients, and liability questions related to the remote nature of the mental health service. VA best practices for remote suicide risk assessment include paradigms for establishing procedures in the context of legal challenges (licensing and involuntary detainment/commitment), for utilizing clinical assessment and triage decision protocols, and for contingency planning to optimize patient care and reduce liability.

  20. Commentary on "The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)": Army STARRS: a Framingham-like study of psychological health risk factors in soldiers.

    Science.gov (United States)

    Ressler, Kerry J; Schoomaker, Eric B

    2014-01-01

    Although historically the Army suicide rate has been significantly lower than the civilian rate, in 2004, the suicide and accidental death rates began trending upward. By 2008, the Army suicide rate had risen above the national average (20.2 per 100,000). In 2009, 160 active duty Soldiers took their lives, making suicide the third leading cause of death among the Army population. If accidental death, frequently the result of high-risk behavior, is included, then more Soldiers died by their own actions than in combat in 2009. The Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) was thus created in 2009 to begin to address these problems. The Army STARRS project is a large consortium of seven different studies to develop data-driven methods for mitigating or preventing suicide behaviors and improving the overall mental health and behavioral functioning of Army Soldiers during and after their Army service. The first research articles from the Army STARRS project were published in late 2013 and early 2014. This work has already begun to outline important facets of risk in the military, and it is helping to drive an empirically derived approach to improvements in understanding mental disorders and risk behavior and to improve prevention and support of mental health and resilience. The Framingham Heart Study, started in the 1940s, marked a watershed event in utilizing large cross-sectional and prospective longitudinal collaborative research to identify and understand risk factors for cardiovascular disease. The Army STARRS project, through its collaborative, prospective, and robust innovative design and implementation, may provide the beginning of a similar scientific cohort in mental disorders. The work of this project will help understand biological and psychological aspects of military service, including those leading to suicide. When coupled with timely feedback to Army leadership, it permits near real-time steps to diagnose, mitigate, and

  1. Assessing the concentration and potential health risk of heavy metals in China’s main deciduous fruits

    Institute of Scientific and Technical Information of China (English)

    NIE Ji-yun; ZHAO Duo-yong; WU Yong-long; CHENG Yang; KUANG Li-xue; LI Zhi-xia; XU Wei-hua; WANG Cheng; CHEN Qiu-sheng; LI An; ZHAO Xu-bo; XIE Han-zhong

    2016-01-01

    To assess levels of contamination and human health risk, we analyzed the concentrations of the heavy metals lead (Pb), cadmium (Cd), chromium (Cr), and nickel (Ni) in China’s main deciduous fruits-apple, pear, peach, grape, and jujube. The concentration order of the heavy metals was Ni>Cr>Pb>Cd. In 97.5% of the samples, heavy metal concentrations were within the maximum permissible limits. Among the fruits studied, the heavy metal concentrations in jujube and peach proved to be the highest, and those in grape proved to be the lowest. Only 2.2% of the samples were poluted by Ni, only 0.4% of the samples were poluted by Pb, and no samples were poluted by Cd or Cr. Compared with the other fruits, the combined heavy metal polution was signiifcantly higher (PCr>Pb>Cd. The highest DIR came from apple, while the lowest DIR came from grape. For each of the heavy metals, the total DIR from ifve studied fruits corresponded to no more than 1.1% of the tolerable daily intake, indicating that no signiifcant adverse health effects are expected from the heavy metals and the fruits studied. The target hazard quotients and the total target hazard quotients demonstrated that none of the analyzed heavy metals may pose risk to consumers through the fruits studied. The highest risk was posed by apple, folowed in decreasing order by peach and pear, jujube, and grape. We suggest that the main deciduous fruits (apple, pear, peach, grape, and jujube) of China’s main producing areas are safe to eat.

  2. Cardiac Risk Assessment

    Science.gov (United States)

    ... Risk Assessment Related tests: Lipid Profile , VLDL Cholesterol , hs-CRP , Lp(a) Overview | Common Questions | Related Pages What ... cardiac risk include: High-sensitivity C-reactive protein (hs-CRP) : Studies have shown that measuring CRP with a ...

  3. Are Metals Emitted from Electronic Cigarettes a Reason for Health Concern? A Risk-Assessment Analysis of Currently Available Literature

    Directory of Open Access Journals (Sweden)

    Konstantinos E. Farsalinos

    2015-05-01

    Full Text Available Background: Studies have found that metals are emitted to the electronic cigarette (EC aerosol. However, the potential health impact of exposure to such metals has not been adequately defined. The purpose of this study was to perform a risk assessment analysis, evaluating the exposure of electronic cigarette (EC users to metal emissions based on findings from the published literature. Methods: Two studies were found in the literature, measuring metals emitted to the aerosol from 13 EC products. We estimated that users take on average 600 EC puffs per day, but we evaluated the daily exposure from 1200 puffs. Estimates of exposure were compared with the chronic Permissible Daily Exposure (PDE from inhalational medications defined by the U.S. Pharmacopeia (cadmium, chromium, copper, lead and nickel, the Minimal Risk Level (MRL defined by the Agency for Toxic Substances and Disease Registry (manganese and the Recommended Exposure Limit (REL defined by the National Institute of Occupational Safety and Health (aluminum, barium, iron, tin, titanium, zinc and zirconium. Results: The average daily exposure from 13 EC products was 2.6 to 387 times lower than the safety cut-off point of PDEs, 325 times lower than the safety limit of MRL and 665 to 77,514 times lower than the safety cut-off point of RELs. Only one of the 13 products was found to result in exposure 10% higher than PDE for one metal (cadmium at the extreme daily use of 1200 puffs. Significant differences in emissions between products were observed. Conclusions: Based on currently available data, overall exposure to metals from EC use is not expected to be of significant health concern for smokers switching to EC use, but is an unnecessary source of exposure for never-smokers. Metal analysis should be expanded to more products and exposure can be further reduced through improvements in product quality and appropriate choice of materials.

  4. Human health risk assessment of mercury vapor around artisanal small-scale gold mining area, Palu city, Central Sulawesi, Indonesia.

    Science.gov (United States)

    Nakazawa, Koyomi; Nagafuchi, Osamu; Kawakami, Tomonori; Inoue, Takanobu; Yokota, Kuriko; Serikawa, Yuka; Cyio, Basir; Elvince, Rosana

    2016-02-01

    Emissions of elemental mercury, Hg(0), from artisanal small-scale gold mining activities accounted for 37% of total global Hg(0) emissions in 2010. People who live near gold-mining areas may be exposed to high concentrations of Hg(0). Here, we assessed the human health risk due to Hg(0) exposure among residents of Palu city (Central Sulawesi Province, Indonesia). The area around the city has more than 60t of gold reserves, and the nearby Poboya area is the most active gold-mining site in Indonesia. Owing to its geography, the city experiences alternating land and sea breezes. Sampling was done over a period of 3 years (from 2010 Aug. to 2012 Dec.) intermittently with a passive sampler for Hg(0), a portable handheld mercury analyzer, and a mercury analyzer in four areas of the city and in the Poboya gold-processing area, as well as wind speeds and directions in one area of the city. The 24-h average concentration, wind speed, and wind direction data show that the ambient air in both the gold-processing area and the city was always covered by high concentration of mercury vapor. The Hg(0) concentration in the city was higher at night than in the daytime, owing to the effect of land breezes. These results indicate that the inhabitants of the city were always exposed to high concentrations of Hg(0). The average daytime point-sample Hg(0) concentrations in the city, as measured with a handheld mercury analyzer over 3 days in July 2011, ranged from 2096 to 3299ngm(-3). In comparison, the average daytime Hg(0) concentration in the Poboya gold-processing area was 12,782ngm(-3). All of these concentrations are substantially higher than the World Health Organization air-quality guideline for annual average Hg exposure (1000ngm(-3)). We used the point-sample concentrations to calculate hazard quotient ratios by means of a probabilistic risk assessment method. The results indicated that 93% of the sample population overall was at risk (hazard quotient ratio ≥1 and cut off at

  5. Future research needs associated with the assessment of potential human health risks from exposure to toxic ambient air pollutants

    DEFF Research Database (Denmark)

    Möller, Lennart; Schuetzle, Dennis; Autrup, Herman

    1994-01-01

    This paper presents key conclusions and future research needs from a Workshop on the Risk Assessment of Urban Air, Emissions, Exposure, Risk Identification, and Quantification, which was held in Stockholm during June 1992 by 41 participants from 13 countries. Research is recommended in the areas...... of identification and quantification of toxics in source emissions and ambient air, atmospheric transport and chemistry, exposure level assessment, the development of improved in vitro bioassays, biomarker development, the development of more accurate epidemiological methodologies, and risk quantification...

  6. Overeating: the health risks.

    Science.gov (United States)

    Prentice, A M

    2001-11-01

    Overeating is a relative term. It refers to the consumption of an energy intake that is inappropriately large for a given energy expenditure, thus, leading to obesity. There are several key environmental and cultural factors that have converged in the past few decades to markedly increase the risk of both active and passive (inadvertent) overeating. Chief among these are the increased availability and promotion of cheap energy-dense diets (usually high in fat) and the transition toward extremely sedentary lifestyles. The importance of considering these factors together must be stressed. Data ranging from highly controlled metabolic studies to large-scale epidemiological and ecological analysis illustrate the strong interactions between diet and physical activity in relationship to the over-consumption of energy. Overeating of certain specific dietary components may also lead to health risks. Obvious examples are saturated and trans-fatty acids. More recently attention has switched to high glycemic foods and to n-6 fatty acids. Theories that excess consumption of these may be independent risk factors for obesity and ill health remain controversial but merit closer examination and additional research. The main barriers to changing widely prevalent overeating include the following: public and corporate ignorance about the effects of energy-dense diets in inducing passive over-consumption, commercial willfulness concerning energy density and portion sizes, and public ignorance about the profound health effects of inactive lifestyles. These represent key targets for the design of public health initiatives.

  7. Health Risk Assessment for Uranium in Groundwater - An Integrated Case Study Based on Hydrogeological Characterization and Dose Calculation

    Science.gov (United States)

    Franklin, M. R.; Veiga, L. H.; Py, D. A., Jr.; Fernandes, H. M.

    2010-12-01

    The uranium mining and milling facilities of Caetité (URA) is the only active uranium production center in Brazil. Operations take place at a very sensitive semi-arid region in the country where water resources are very scarce. Therefore, any contamination of the existing water bodies may trigger critical consequences to local communities because their sustainability is closely related to the availability of the groundwater resources. Due to the existence of several uranium anomalies in the region, groundwater can present radionuclide concentrations above the world average. The radiological risk associated to the ingestion of these waters have been questioned by members of the local communities, NGO’s and even regulatory bodies that suspected that the observed levels of radionuclide concentrations (specially Unat) could be related to the uranium mining and milling operations. Regardless the origin of these concentrations the fear that undesired health effects were taking place (e.g. increase in cancer incidence) remain despite the fact that no evidence - based on epidemiological studies - is available. This paper intends to present the connections between the local hydrogeology and the radiological characterization of groundwater in the neighboring areas of the uranium production center to understand the implications to the human health risk due to the ingestion of groundwater. The risk assessment was performed, taking into account the radiological and the toxicological risks. Samples from 12 wells have been collected and determinations of Unat, Thnat, 226Ra, 228Ra and 210Pb were performed. The radiation-related risks were estimated for adults and children by the calculation of the annual effective doses. The potential non-carcinogenic effects due to the ingestion of uranium were evaluated by the estimation of the hazard index (HI). Monte Carlo simulations were used to calculate the uncertainty associated with these estimates, i.e. the 95% confidence interval

  8. Distribution of heavy metals in muscles and internal organs of Korean cephalopods and crustaceans: risk assessment for human health.

    Science.gov (United States)

    Mok, Jong Soo; Kwon, Ji Young; Son, Kwang Tae; Choi, Woo Seok; Shim, Kil Bo; Lee, Tae Seek; Kim, Ji Hoe

    2014-12-01

    Samples of seven species of cephalopods and crustaceans were collected from major fish markets on the Korean coast and analyzed for mercury (Hg) using a direct Hg analyzer and for the metals cadmium (Cd), lead (Pb), chromium, silver, nickel, copper, and zinc using inductively coupled plasma mass spectrometry. The distributions of heavy metals in muscles, internal organs, and whole tissues were determined, and a risk assessment was conducted to provide information concerning consumer safety. The heavy metals accumulated to higher levels (P organs than in muscles for all species. The mean concentrations of Cd, which had the highest concentrations of the three hazardous metals (Cd, Pb, and Hg), in all internal organs (except those of blue crab) exceeded the regulatory limits set by Korea and the European Union. The Cd concentrations in all whole tissues of squid and octopus (relatively large cephalopods), red snow crab, and snow crab exceeded the European Union limits. The estimated dietary intake of Cd, Pb, and Hg for each part of all species accounted for 1.73 to 130.57%, 0.03 to 0.39%, and 0.93 to 1.67%, respectively, of the provisional tolerable daily intake adopted by the Joint Food and Agriculture Organization and World Health Organization Expert Committee on Food Additives; the highest values were found in internal organs. The hazard index (HI) is recognized as a reasonable parameter for assessing the risk of heavy metal consumption associated with contaminated food. Because of the high HI (>1.0) of the internal organs of cephalopods and the maximum HI for whole tissue of 0.424, consumers eating internal organs or whole tissues of cephalopods could be at risk of high heavy metal exposure. Therefore, the internal organs of relatively large cephalopods and crabs (except blue crab) are unfit for consumption. However, consumption of flesh after removing internal organs is a suitable approach for decreasing exposure to harmful metals.

  9. Determination of the bioaccessibility of chromium in Glasgow soil and the implications for human health risk assessment.

    Science.gov (United States)

    Broadway, Andrew; Cave, Mark R; Wragg, Joanna; Fordyce, Fiona M; Bewley, Richard J F; Graham, Margaret C; Ngwenya, Bryne T; Farmer, John G

    2010-12-15

    The Unified Bioaccessibility Method (UBM), which simulates the fluids of the human gastrointestinal tract, was used to assess the oral bioaccessibility of Cr in 27 Glasgow soils. These included several contaminated with Cr(VI), the most toxic form of Cr, from the past disposal of chromite ore processing residue (COPR). The extraction was employed in conjunction with the subsequent determination of the bioaccessible Cr by ICP-OES and Cr(VI) by the diphenylcarbazide complexation colorimetric procedure. In addition, Cr(III)-containing species were determined by (i) HPLC-ICP-MS and (ii) ICP-OES analysis of gel electrophoretically separated components of colloidal and dissolved fractions from centrifugal ultrafiltration of extracts. Similar analytical procedures were applied to the determination of Cr and its species in extracts of the complexes. Insertion of oral bioaccessible fraction data into the SNIFFER human health risk assessment model identified site-specific assessment criteria (for residential land without plant uptake) that were exceeded by the soil total Cr (3680 mg kg(-1)) and Cr(VI) (1485 mg kg(-1)) concentration at only the most COPR-Cr(VI)-contaminated location. However, the presence of measurable Cr(VI) in the <10 μm fraction of the two most highly Cr(VI)-contaminated soils demonstrated that inhalation of Cr(VI)-containing dust remains the most potentially harmful exposure route.

  10. Ranking of fungicides according to risk assessments for health and environment

    DEFF Research Database (Denmark)

    Jørgensen, Lise Nistrup; Ørum, Jens Erik

    2014-01-01

    Denmark has introduced a new indicator for ranking the potential impact of pesticides on health and environment. The new Pesticide Load (PL) makes it possible for farmers to choose the least harmful fungicides and substitute between products which have an equally good efficacy profile. In practic...... system it is expected that the system could lead to more problems related to pesticide resistance.......Denmark has introduced a new indicator for ranking the potential impact of pesticides on health and environment. The new Pesticide Load (PL) makes it possible for farmers to choose the least harmful fungicides and substitute between products which have an equally good efficacy profile. In practice...... PL varies for fungicide standard rates by a factor of 10. Products including epoxiconazole generally have higher PL's due to the human health profile of this active. PL's per area, crop or product will supplement the previous pesticide statistics based on treatment frequency index (TFI). PL has also...

  11. Chapter 6: Ecotoxicology, Environmental Risk Assessment & Potential Impact on Human Health

    Science.gov (United States)

    This chapter examines potential risks posed by pharmaceuticals present in the aquatic environment to humans and aquatic life. We begin by describing the mechanisms by which pharmaceuticals enter the vertebrate body, produce effects and leave the body. Then we describe theoretical...

  12. Nitrate and nitrite in the diet: How to assess their benefit and risk for human health

    NARCIS (Netherlands)

    Habermeyer, M.; Roth, A.; Guth, S.; Rietjens, I.M.C.M.

    2015-01-01

    Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction

  13. Ranking of fungicides according to risk assessments for health and environment

    DEFF Research Database (Denmark)

    Jørgensen, Lise Nistrup; Ørum, Jens Erik

    2014-01-01

    Denmark has introduced a new indicator for ranking the potential impact of pesticides on health and environment. The new Pesticide Load (PL) makes it possible for farmers to choose the least harmful fungicides and substitute between products which have an equally good efficacy profile. In practice...... PL varies for fungicide standard rates by a factor of 10. Products including epoxiconazole generally have higher PL's due to the human health profile of this active. PL's per area, crop or product will supplement the previous pesticide statistics based on treatment frequency index (TFI). PL has also...

  14. Krypton-85 health risk assessment for a nuclear fuel reprocessing plant

    Energy Technology Data Exchange (ETDEWEB)

    Mellinger, P.J.; Brackenbush, L.W.; Tanner, J.E.; Gilbert, E.S.

    1984-08-01

    The risks involved in the routine release of /sup 85/Kr from nuclear fuel reprocessing operations to the environment were compared to those resulting from the capture and storage of /sup 85/Kr. Instead of releasing the /sup 85/Kr to the environment when fuel is reprocessed, it can be captured, immobilized and stored. Two alternative methods of capturing /sup 85/Kr (cryogenic distillation and fluorocarbon absorption) and one method of immobilizing the captured gas (ion implantation/sputtering) were theoretically incorporated into a representative fuel reprocessing plant, the Barnwell Nuclear Fuel Plant, even though there are no known plans to start up this facility. Given the uncertainties in the models used to generate lifetime risk numbers (0.02 to 0.027 radiation induced fatal cancers expected in the occupational workforce and 0.017 fatal cancers in the general population), the differences in total risks for the three situations, (i.e., no-capture and two-capture alternatives) cannot be considered meaningful. It is possible that no risks would occur from any of the three situations. There is certainly no reason to conclude that risks from /sup 85/Kr routinely released to the environment are greater than those that would result from the other two situations considered. Present regulations mandate recovery and disposal of /sup 85/Kr from the off gases of a facility reprocessing spent fuel from commercial sources. Because of the lack of a clear-cut indication that recovery woud be beneficial, it does not seem prudent to burden the facilities with a requirement for /sup 85/Kr recovery, at least until operating experience demonstrates the incentive. The probable high aging of the early fuel to be processed and the higher dose resulting from the release of the unregulated /sup 3/H and /sup 14/C also encourage delaying implementation of the /sup 85/Kr recovery in the early plants.

  15. Source, distribution, and health risk assessment of polycyclic aromatic hydrocarbons in urban street dust from Tianjin, China.

    Science.gov (United States)

    Yu, Binbin; Xie, Xiujie; Ma, Lena Q; Kan, Haidong; Zhou, Qixing

    2014-02-01

    To better assess and understand potential health risk of urban residents exposed to urban street dust, the total concentration, sources, and distribution of 16 polycyclic aromatic hydrocarbons (PAHs) in 87 urban street dust samples from Tianjin as a Chinese megacity that has undergone rapid urbanization were investigated. In the meantime, potential sources of PAHs were identified using the principal component analysis (PCA), and the risk of residents' exposure to PAHs via urban street dust was calculated using the Incremental Lifetime Cancer Risk (ILCR) model. The results showed that the total PAHs (∑PAHs) in urban street dust from Tianjin ranged from 538 μg kg(-1) to 34.3 mg kg(-1), averaging 7.99 mg kg(-1). According to PCA, the two to three- and four to six-ring PAHs contributed 10.3 and 89.7 % of ∑PAHs, respectively. The ratio of the sum of major combustion specific compounds (ΣCOMB) / ∑PAHs varied from 0.57 to 0.79, averaging 0.64. The ratio of Ant/(Ant + Phe) varied from 0.05 to 0.41, averaging 0.10; Fla/(Fla + Pyr) from 0.40 to 0.68, averaging 0.60; BaA/(BaA + Chry) from 0.29 to 0.51, averaging 0.38; and IcdP/(IcdP + BghiP) from 0.07 to 0.37, averaging 0.22. The biomass combustion, coal combustion, and traffic emission were the main sources of PAHs in urban street dust with the similar proportion. According to the ILCR model, the total cancer risk for children and adults was up to 2.55 × 10(-5) and 9.33 × 10(-5), respectively.

  16. Integrated modelling for assessing the risk of groundwater contaminants to human health and surface water ecosystems

    DEFF Research Database (Denmark)

    McKnight, Ursula S.; Rasmussen, Jes; Funder, Simon G.;

    2010-01-01

    for evaluating the impact of a TCE groundwater plume, located in an area with protected drinking water interests, to human health and surface water ecosystems. This is accomplished by coupling the system dynamicsbased decision support system CARO-Plus to the aquatic ecosystem model AQUATOX via an analytical...

  17. Ranking of fungicides according to risk assessments for health and environment

    DEFF Research Database (Denmark)

    Jørgensen, Lise Nistrup; Ørum, Jens Erik

    2014-01-01

    Denmark has introduced a new indicator for ranking the potential impact of pesticides on health and environment. The new Pesticide Load (PL) makes it possible for farmers to choose the least harmful fungicides and substitute between products which have an equally good efficacy profile. In practice...

  18. Health risk assessment of pentachlorophenol (pcp) in California drinking water. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Reed, N.R.; Reed, W.A.; Encomienda, I.; Beltran, L.; Araba-Owoyele, L.

    1990-03-08

    The purpose of the document is to review the toxicology of PCP and to estimate the exposure of California residents to PCP found in drinking water. The information provided will help the California Dept. of Health Services develop drinking water standards for PCP.

  19. Influence of environmental chemicals on epigenetic programming and its applicability in human health risk assessment.

    Science.gov (United States)

    The field of epigenetics is rapidly evolving in response to the growing concern that heritable changes in gene expression may be involved in chemically-mediated adverse health outcomes, such as cancer. Although human and animal studies have shown a strong involvement of epigeneti...

  20. Human health risk assessment of the mixture of pharmaceuticals in Dutch drinking water and its sources based on frequent monitoring data.

    Science.gov (United States)

    Houtman, Corine J; Kroesbergen, Jan; Lekkerkerker-Teunissen, Karin; van der Hoek, Jan Peter

    2014-10-15

    The presence of pharmaceuticals in drinking water is a topic of concern. Previous risk assessments indicate that their low concentrations are very unlikely to pose risks to human health, however often conclusions had to be based on small datasets and mixture effects were not included. The objectives of this study were to a) investigate if pharmaceuticals in surface and polder water penetrate in drinking water, b) assess the lifelong exposure of consumers to pharmaceuticals via drinking water and c) assess the possible individual and mixture health risks associated with this exposure. To fulfill these aims, a 2-year set of 4-weekly monitoring data of pharmaceuticals was used from three drinking water production plants. The 42 pharmaceuticals that were monitored were selected according to their consumption volume, earlier detection, toxicity and representation of the most relevant therapeutic classes. Lifelong exposures were calculated from concentrations and compared with therapeutic doses. Health risks were assessed by benchmarking concentrations with provisional guideline values. Combined risks of mixtures of pharmaceuticals were estimated using the concept of Concentration Addition. The lifelong exposure to pharmaceuticals via drinking water was calculated to be extremely low, i.e. a few mg, in total corresponding to risk of adverse health effects appeared to be negligibly low. Application of Concentration Addition confirmed this for the mixture of pharmaceuticals simultaneously present. The investigated treatment plants appeared to reduce the (already negligible) risk up to 80%. The large available monitoring dataset enabled the performance of a realistic risk assessment. It showed that working with maximum instead of average concentrations may overestimate the risk considerably.

  1. Screening Health Risk Assessment Burn Pit Exposures, Balad Air Base, Iraq and Addendum Report

    Science.gov (United States)

    2008-05-01

    http://deploymenthealthlibrary.fhp.osd.mil/accessLog.jsp?prodid=313). ii. Health Effects of Dioxin Exposure for Service Members, (http...uncertainty, regulatory agencies try to lower dioxin exposure levels in human populations as much as possible. g. Recent research has shown that some...pit, time spent indoors versus outdoors, frequency of meteorological conditions promoting exposure, or other factors that could impact dioxin

  2. HEALTH CONCERNS ON FISHERY PRODUCTS: ANTIBIOTIC RESISTANCE AND PARASITE RISK ASSESSMENT IN FISH PRODUCTION VALUE CHAINS

    OpenAIRE

    Smaldone, Giorgio

    2014-01-01

    Capture fisheries and aquaculture supplied the world with about 148 million tonnes of fish in 2010, of which about 128 million tonnes were utilized as food for people. The fishery market is becoming much more complex and stratified, with greater diversification among species and product forms and for this reason food safety remains a major concern facing the seafood industry. Along fish value chain there are a lot of concern regarding public health and for this reason the aim of this work was...

  3. Phase 1 data summary report for the Clinch River Remedial Investigation: Health risk and ecological risk screening assessment. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Cook, R.B.; Adams, S.M.; Beauchamp, J.J.; Bevelhimer, M.S.; Blaylock, B.G.; Brandt, C.C.; Ford, C.J.; Frank, M.L.; Gentry, M.J.; Holladay, S.K.; Hook, L.A.; Levine, D.A.; Longman, R.C.; McGinn, C.W.; Skiles, J.L.; Suter, G.W.; Williams, L.F.

    1992-12-01

    The Clinch River Remedial Investigation (CRRI) is designed to address the transport, fate, and distribution of waterborne contaminants released from the US Department of Energy`s (DOE`s) Oak Ridge Reservation (ORR) and to assess potential risks to human health and the environment associated with these contaminants. The contaminants released since the early 1940s include a variety of radionuclides, metals, and organic compounds. The purpose of this report is to summarize the results of Phase 1 of the CRRI. Phase 1 was designed to (1) obtain high-quality data to confirm existing historical data for contaminant levels in fish, sediment, and water from the CR/WBR; (2) determine the in the range of contaminant concentrations present river-reservoir system; (3) identify specific contaminants of concern; and (4) establish the reference (background) concentrations for those contaminants.

  4. Pollution distribution and health risk assessment of heavy metals in indoor dust in Anhui rural, China.

    Science.gov (United States)

    Lin, Yuesheng; Fang, Fengman; Wang, Fei; Xu, Minglu

    2015-09-01

    Zn, Pb, Cu, Cr, V, Ni, Co, and As concentrations of indoor dust in Anhui rural were determined by inductively coupled plasma-optical emission spectroscopy (ICP-OES). The degrees of metal pollution in indoor dust ranked as follows: Zn > Pb > Cr > Cu > V > Ni > Co > As, on average. The arithmetic means of Zn, Pb, Cu, Cr, V, Ni, Co, and As were 427.17, 348.73, 107.05, 113.68, 52.64, 38.93, 10.29, and 4.46 mg/kg, respectively. These were higher than background values of Anhui soil for Zn, Pb, Cu, Cr, and Ni, especially for Pb with the mean value of 13.21 times the background value. Heavy metal concentrations of indoor dust were different from different rural areas. House type (bungalows or storied house), sweeping frequency, and external environment around the house (such as the road grade) affected heavy metal concentrations in indoor dust. The results of factor analysis and correlation analysis indicated that Cu, Cr, Ni, Zn, and Co concentrations were mainly due to interior paint, metal objects, and building materials. Pb and As concentrations were due to vehicle emissions. V concentration was mainly of natural source. Average daily doses for the exposure pathway of the studied heavy metals decreased in children in the following order: hand-to-mouth ingestion > dermal contact > inhalation. The non-carcinogenic risks of heavy metals ranked as Pb > V > Cr > Cu > Zn > As > Co > Ni, and the carcinogenic risks of metals decreased in the order of Cr > Co > As > Ni. The non-carcinogenic hazard indexes and carcinogenic risks of metals in indoor dust were both lower than the safe values.

  5. Respiratory health risk assessment of children living close to industrial areas in Indonesia.

    Science.gov (United States)

    Salami, Indah R S; As, Zulfikar A; Marselina, Mariana; Roosmini, Dwina

    2014-01-01

    Industrial areas are considered to have higher risk of air pollution impact especially to children living close to the industry. Two separate industrial areas in Indonesia were compared. The first location was in the area of coal transportation activity in South Kalimantan, and the second location was in the area of Bogor, West Java where used battery processing industry was often found. Fifty children (boys and girls, aged 6-15 years) were involved in South Kalimantan whereas in West Java there were 48 children (boys and girls, aged 10-12 years) involved. The control groups were also studied in both areas. Predicted average daily intake (ADD) of respirable particulate was estimated and respiratory function was measured using spirometer. The study showed that the PM2.5 concentration in industrial area was 3 times higher than those found in the control location. As a result, the predicted ADD of particulate of children living close to industry in South Kalimantan was 25.45±10.55 µg/kg.day whereas in West Java, the ADD was 1.5 times higher. For both studied area, boys' respirable particulate intake was shown to have higher intake than those in girls. Lung function of children revealed that more than 68% of children in the coal transportation area had decreased pulmonary function. The study also noted that some children in West Java had indicated an obstructive and restrictive respiratory condition. The risk of girls having mild lung disease was found to be 1.3 times greater than those in the control group whereas in boys, the risk was 1.9 times than those in control area. Respiratory function of children in West Java study area was considered to worsen by the higher Pb emission from used battery processing activity.

  6. Heavy metals health risk assessment for population via consumption of food crops and fruits in Owerri, South Eastern, Nigeria

    Directory of Open Access Journals (Sweden)

    Orisakwe Orish

    2012-08-01

    Full Text Available Abstract Background This study assessed lead, cadmium, and nickel level in food crops, fruits and soil samples from Ohaji and Umuagwo and Owerri in South Eastern Nigeria and estimated the potential health risks of metals. Samples were washed, oven-dried at 70–80°C for 24 h and powdered. Samples were digested with perchloric acid and nitric acid. Metals were analysed with Unicam Atomic Absorption Spectrophotometer. Result The concentration of Pb, Cd, and Ni in Ohaji exceeded the maximum allowable concentrations for agricultural soil as recommended by EU. Lead, Cd, and Ni in the food crops were highest in Oryza sativa, Glycine max, and Pentabacta microfila respectively. Highest levels of Pb, Cd, and Ni, in fruits were detected in Canarium schweinfurthii, Citrus reticulata, Ananas comosus respectively. The true lead and cadmium intake for the rice based meal were 3.53 and 0.034 g/kg respectively. Whereas the true intake of lead and cadmium for the cassava based meal were 19.42 and 0.049 g/kg respectively. Conclusion Local food stuff commonly available in South Eastern Nigeria villages may contribute to the body burden of heavy metal. This is of public health importance.

  7. Projection models for health-effects assessment in populations exposed to radioactive and nonradioactive pollutants. Volume I. Introduction to the SPAHR demographic model for health risk

    Energy Technology Data Exchange (ETDEWEB)

    Collins, J.J.; Lundy, R.T.; Grahn, D.; Ginevan, M.E.

    1982-09-01

    The Simulation Package for the Analysis of Health Risk (SPAHR) is a computer software package based upon a demographic model for health risk projections. The model extends several health risk projection models by making realistic assumptions about the population at risk, and thus represents a distinct improvement over previous models. Complete documentation for use of SPAHR is contained in this five-volume publication. The demographic model in SPAHR estimates population response to environmental toxic exposures. Latency of response, changing dose level over time, competing risks from other causes of death, and population structure can be incorporated into SPAHR to project health risks. Risks are measured by morbid years, number of deaths, and loss of life expectancy. Comparisons of estimates of excess deaths demonstrate that previous health risk projection models may have underestimated excess deaths by a factor of from 2 to 10, depending on the pollutant and the exposure scenario. The software supporting the use of the demographic model is designed to be user oriented. Complex risk projections are made by responding to a series of prompts generated by the package. The flexibility and ease of use of SPAHR make it an important contribution to existing models and software packages. The first volume presents the theory behind the SPAHR health risk projection model and several applications of the model to actual pollution episodes. The elements required for an effective health risk projection model are specified, and the models that have been used to date in health risk projections are outlined. These are compared with the demographic model, whose formulation is described in detail. Examples of the application of air pollution and radiation dose-response functions are included in order to demonstrate the estimation of future mortality and morbidity levels and the range of variation in excess deaths that occurs when populations structure is changed.

  8. Discussion on the method of health risk assessment of osteoporosis%骨质疏松健康风险评估方法探讨

    Institute of Scientific and Technical Information of China (English)

    杜天信; 赵移畛; 王春秋; 李文霞

    2015-01-01

    目的:结合国内健康管理发展的现状,构建骨质疏松健康风险评估的模型。方法:依托骨科医院的优势对骨质疏松症各项指标进行综合,以软件评估问卷形式对人员进行健康风险评估。结果:用骨质疏松健康风险评估方法的建立可以帮助预测骨质疏松症状并提供相应的预防或治疗措施。结论:该方法简便科学,并能快速评价病情症状,为疾病的预防及治疗提供便捷参考。%Objective:To build the model of health risk assessment of osteoporosis combined with the present situation in health risk assessment processing. Method:To sum up the indexes of osteoporosis in the orthopaedic hospital and evaluate the health risk assessment of osteoporosis by questionnaire. Result:It can help forecasting the risk of osteoporosis and providing prevention and treatment via health risk assessment of osteoporosis.Conclusion:It is convenient and scientific to evaluate the symptoms in order to provide the reference of treatment.

  9. Human health risk assessment of chloroxylenol in liquid hand soap and dishwashing soap used by consumers and health-care professionals.

    Science.gov (United States)

    Yost, Lisa J; Rodricks, Joseph D; Turnbull, Duncan; DeLeo, Paul C; Nash, J Frank; Quiñones-Rivera, Antonio; Carlson, Pete A

    2016-10-01

    A quantitative human risk assessment of chloroxylenol was conducted for liquid hand and dishwashing soap products used by consumers and health-care workers. The toxicological data for chloroxylenol indicate lack of genotoxicity, no evidence of carcinogenicity, and minimal systemic toxicity. No observed adverse effect levels (NOAEL) were established from chronic toxicity studies, specifically a carcinogenicity study that found no cancer excess (18 mg/kg-day) and studies of developmental and reproductive toxicity (100 mg/kg-day). Exposure to chloroxylenol for adults and children was estimated for two types of rinse-off cleaning products, one liquid hand soap, and two dishwashing products. The identified NOAELs were used together with exposure estimates to derive margin of exposure (MOE) estimates for chloroxylenol (i.e., estimates of exposure over NOAELs). These estimates were designed with conservative assumptions and likely overestimate exposure and risk (i.e., highest frequency, 100% dermal penetration). The resulting MOEs ranged from 178 to over 100, 000, 000 indicating negligibly small potential for harm related to consumer or health-care worker exposure to chloroxylenol in liquid soaps used in dish washing and hand washing.

  10. [The urgent problems of the improvement of the environment management system based on the analysis of health risk assessment].

    Science.gov (United States)

    Avaliani, S L; Novikov, S M; Shashina, T A; Dodina, N S; Kislitsin, V A; Mishina, A L

    2014-01-01

    The lack of adequate legislative and regulatory framework for ensuring minimization of the health risks in the field of environmental protection is the obstacle for the application of the risk analysis methodology as a leading tool for administrative activity in Russia. "Principles of the state policy in the sphere of ensuring chemical and biological safety of the Russian Federation for the period up to 2025 and beyond", approved by the President of the Russian Federation on 01 November 2013, No PR-25 73, are aimed at the legal support for the health risk analysis methodology. In the article there have been supposed the main stages of the operative control of the environmental quality, which lead to the reduction of the health risk to the acceptable level. The further improvement of the health risk analysis methodology in Russia should contribute to the implementation of the state policy in the sphere of chemical and biological safety through the introduction of complex measures on neutralization of chemical and biological threats to the human health and the environment, as well as evaluation of the economic effectiveness of these measures. The primary step should be the legislative securing of the quantitative value for the term: "acceptable risk".

  11. Health Risk Assessment of Ambient Air Concentrations of Benzene, Toluene and Xylene (BTX in Service Station Environments

    Directory of Open Access Journals (Sweden)

    Benjamin Edokpolo

    2014-06-01

    Full Text Available A comprehensive evaluation of the adverse health effects of human exposures to BTX from service station emissions was carried out using BTX exposure data from the scientific literature. The data was grouped into different scenarios based on activity, location and occupation and plotted as Cumulative Probability Distributions (CPD plots. Health risk was evaluated for each scenario using the Hazard Quotient (HQ at 50% (CEXP50 and 95% (CEXP95 exposure levels. HQ50 and HQ95 > 1 were obtained with benzene in the scenario for service station attendants and mechanics repairing petrol dispensing pumps indicating a possible health risk. The risk was minimized for service stations using vapour recovery systems which greatly reduced the benzene exposure levels. HQ50 and HQ95 < 1 were obtained for all other scenarios with benzene suggesting minimal risk for most of the exposed population. However, HQ50 and HQ95 < 1 was also found with toluene and xylene for all scenarios, suggesting minimal health risk. The lifetime excess Cancer Risk (CR and Overall Risk Probability for cancer on exposure to benzene was calculated for all Scenarios and this was higher amongst service station attendants than any other scenario.

  12. An Assessment of the Health Risks of Seven Pesticides Used for Termite Control.

    Science.gov (United States)

    1982-08-01

    N9SS±4-SI-C-S161 UNCLASSIFIED F/B 6/29 9L HIM AG1.8 11.25 . 1. MICROCOPY RESOLUIION TESI CHARI NAII A N A RIPAi 0 A flTA h ’N" AM ASSESSMENT OF THE...Three cases of aplastic anemia and three cases of acute leukemia associated with chlordane exposure were diagnosed in the same period. The five...investigators should look for signs of neurotoxicity--such as seizures, movement disorders, tremors, and chorea--and for signs of anemia and diseases

  13. Quantitative microbial risk assessment (QMRA) shows increased public health risk associated with exposure to river water under conditions of riverbed sediment resuspension.

    Science.gov (United States)

    Abia, Akebe Luther King; Ubomba-Jaswa, Eunice; Genthe, Bettina; Momba, Maggy Ndombo Benteke

    2016-10-01

    Although higher microbial concentrations have been reported in sediments than in the overlying water column, most quantitative microbial risk assessment (QMRA) studies have not clearly indicated the contribution of sediment-borne pathogens to estimated risks. Thus, the present study aimed at determining the public health risk associated with exposure to pathogenic bacteria in polluted river water under undisturbed conditions and conditions of sediment resuspension in the Apies River, Gauteng, South Africa. Microbial pathogens were isolated and identified using culture and molecular methods. The beta-Poisson dose-response model was used to estimate the probability of infection (Pi) with the various pathogens, following accidental/intentional ingestion of 1mL or 100mL (or 50mL) of untreated river water. Mean wet season Escherichia coli counts ranged between 5.8E+01 and 8.8E+04MPN/100mL (water column) and between 2.40E+03 and 1.28E+05MPN/100mL (sediments). Mean dry season E. coli counts ranged between 5.11E+00 and 3.40E+03MPN/100mL (water column) and between 5.09E+00 and 6.30E+03MPN/100mL (sediments). Overall (water and sediments) Vibrio cholerae was the most detected pathogen (58.8%) followed by Salmonella spp. (23.9%) and Shigella (10.1%). Ingestion of 1mL of river water could lead to 0%-4% and 1%-74% Pi with E. coli during the dry and wet season, respectively. During the dry season, the Pi with V. cholerae, Salmonella spp. and Shigella spp. were 0%-1.39%, 0%-4.11% and 0%-0.16% respectively, depending on volume of water ingested. The risks of infections with all microorganisms increased during the wet season. A 2-log increase in water E. coli count following sediments disturbance led to approximately 10 times higher Pi with E. coli than when sediments were undisturbed. Therefore, the use of the untreated water from the Apies River for drinking, household purposes or recreational activities poses a potential health risk to the users of the river.

  14. Global ozone and air quality: a multi-model assessment of risks to human health and crops

    Directory of Open Access Journals (Sweden)

    K. Ellingsen

    2008-02-01

    assessment of the risks to human health and vegetation from changing levels of surface ozone.

  15. Global ozone and air quality: a multi-model assessment of risks to human health and crops

    Science.gov (United States)

    Ellingsen, K.; Gauss, M.; van Dingenen, R.; Dentener, F. J.; Emberson, L.; Fiore, A. M.; Schultz, M. G.; Stevenson, D. S.; Ashmore, M. R.; Atherton, C. S.; Bergmann, D. J.; Bey, I.; Butler, T.; Drevet, J.; Eskes, H.; Hauglustaine, D. A.; Isaksen, I. S. A.; Horowitz, L. W.; Krol, M.; Lamarque, J. F.; Lawrence, M. G.; van Noije, T.; Pyle, J.; Rast, S.; Rodriguez, J.; Savage, N.; Strahan, S.; Sudo, K.; Szopa, S.; Wild, O.

    2008-02-01

    Within ACCENT, a European Network of Excellence, eighteen atmospheric models from the U.S., Europe, and Japan calculated present (2000) and future (2030) concentrations of ozone at the Earth's surface with hourly temporal resolution. Comparison of model results with surface ozone measurements in 14 world regions indicates that levels and seasonality of surface ozone in North America and Europe are characterized well by global models, with annual average biases typically within 5-10 nmol/mol. However, comparison with rather sparse observations over some regions suggest that most models overestimate annual ozone by 15-20 nmol/mol in some locations. Two scenarios from the International Institute for Applied Systems Analysis (IIASA) and one from the Intergovernmental Panel on Climate Change Special Report on Emissions Scenarios (IPCC SRES) have been implemented in the models. This study focuses on changes in near-surface ozone and their effects on human health and vegetation. Different indices and air quality standards are used to characterise air quality. We show that often the calculated changes in the different indices are closely inter-related. Indices using lower thresholds are more consistent between the models, and are recommended for global model analysis. Our analysis indicates that currently about two-thirds of the regions considered do not meet health air quality standards, whereas only 2-4 regions remain below the threshold. Calculated air quality exceedances show moderate deterioration by 2030 if current emissions legislation is followed and slight improvements if current emissions reduction technology is used optimally. For the "business as usual" scenario severe air quality problems are predicted. We show that model simulations of air quality indices are particularly sensitive to how well ozone is represented, and improved accuracy is needed for future projections. Additional measurements are needed to allow a more quantitative assessment of the risks to

  16. Arsenic and arsenic species in shellfish and finfish from the western Arabian Gulf and consumer health risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Krishnakumar, Periyadan K., E-mail: kkumarpk@kfupm.edu.sa [Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Qurban, Mohammad A. [Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Stiboller, Michael [Institute of Chemistry-Analytical Chemistry, NAWI Graz, University of Graz, A-8010 Graz (Austria); Nachman, Keeve E. [Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health Sciences, Baltimore, MD (United States); Joydas, Thadickal V.; Manikandan, Karuppasamy P.; Mushir, Shemsi Ahsan [Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 31261 (Saudi Arabia); Francesconi, Kevin A. [Institute of Chemistry-Analytical Chemistry, NAWI Graz, University of Graz, A-8010 Graz (Austria)

    2016-10-01

    the major fraction (~ 70%) of total arsenic. • Toxic inorganic arsenic presents at only low levels (< 1.84% of total As). • No significant relationship between the tissue concentrations of total As and iAs. • Health risk assessment shows non-negligible risks and the potential for hazards.

  17. Integration of an Evidence Base into a Probabilistic Risk Assessment Model. The Integrated Medical Model Database: An Organized Evidence Base for Assessing In-Flight Crew Health Risk and System Design

    Science.gov (United States)

    Saile, Lynn; Lopez, Vilma; Bickham, Grandin; FreiredeCarvalho, Mary; Kerstman, Eric; Byrne, Vicky; Butler, Douglas; Myers, Jerry; Walton, Marlei

    2011-01-01

    This slide presentation reviews the Integrated Medical Model (IMM) database, which is an organized evidence base for assessing in-flight crew health risk. The database is a relational database accessible to many people. The database quantifies the model inputs by a ranking based on the highest value of the data as Level of Evidence (LOE) and the quality of evidence (QOE) score that provides an assessment of the evidence base for each medical condition. The IMM evidence base has already been able to provide invaluable information for designers, and for other uses.

  18. Hygienic risk assessment of children with somatic health problems associated with vitamin deficiency

    Directory of Open Access Journals (Sweden)

    O.J. Ustinova

    2015-12-01

    Full Text Available A study of the seasonal provision of children attending pre-school organizations that implement the standard artificial diet fortification with vitamins A, C, D, E, В 6 and B 12 was performed. It was found that 75–85 % of children have a yearround vitamin deficiency and 40 % cases have the status of polyhypovitaminose. In autumn and winter the provision of children with vitamins corresponds to the physiological needs, but in the spring months 70 % of children have a deficit in vitamin C, and 15 % – in vitamin A. Even in autumn, every third child has a deficiency in vitamin B6, and every tenth – in vitamin D; in the spring the number of children with insufficient provision of these vitamins increases in 1.8–6.3 times. Half of the children, who attend pre-school organizations, have year-round vitamin B12 deficiency. Deficiency of vitamins up to 3 times increases the risk of developing disorders of physical development of children, dysfunction processes of vascular tone regulation and autonomic reactivity, and the incidence of chronic diseases of children is increased in 1.3–2.2 times.

  19. Nanocomposites in food packaging applications and their risk assessment for health.

    Science.gov (United States)

    Honarvar, Zohreh; Hadian, Zahra; Mashayekh, Morteza

    2016-06-01

    Nanotechnology has shown many advantages in different fields. As the uses of nanotechnology have progressed, it has been found to be a promising technology for the food packaging industry in the global market. It has proven capabilities that are valuable in packaging foods, including improved barriers; mechanical, thermal, and biodegradable properties; and applications in active and intelligent food packaging. Examples of the latter are anti-microbial agents and nanosensors, respectively. However, the use of nanocomposites in food packaging might be challenging due to the reduced particle size of nanomaterials and the fact that the chemical and physical characteristics of such tiny materials may be quite different from those of their macro-scale counterparts. In order to discuss the potential risks of nanoparticles for consumers, in addition to the quantification of data, a thorough investigation of their characteristics is required. Migration studies must be conducted to determine the amounts of nanomaterials released into the food matrices. In this article, different applications of nanocomposites in food packaging, migration issues, analyzing techniques, and the main concerns about their usage are discussed briefly.

  20. Risk assessment for human health and terrestrial ecosystem under chronic radioactive pollution near regional radioactive waste storage

    Science.gov (United States)

    Lavrentyeva, G. V.; Katkova, M. N.; Shoshina, R. R.; Synzynys, B. I.

    2017-01-01

    An impact of the radioactive waste storage facility at the regional population was assessed under supervision of IAEA. It was made in accordance with the methodology for assessment of doses and risks to human storage using different scenarios of radionuclides releases into the environment. The following scenarios were considered: leakage of fluid, resuspension of dust, fire, flooding. Thy evaluation of radiation doses received and the risks to the human showed that the risk has been acceptable for all scenarios. An approach for an ecological risk assessment for terrestrial ecosystem is presented as five modules: selection of the ecosystem-receptor of radiation effects; determination of reference species of living organisms and their survival indices; the critical load as an absorbed dose rate is calculated from the dependence between the absorbed Sr-90 radiation dose rate and the coefficient of radioactive strontium accumulation in mollusc shells; the critical dose; risk is assessed from a part of the ecosystem territory with increased mollusc loading; uncertainties appeared at each stage of risk assessment are characterized. The risk of exposure to the repository on the ecosystem should be characterized as unacceptable.

  1. Health risk assessment of lead for children in tinfoil manufacturing and e-waste recycling areas of Zhejiang Province, China

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiaofeng, E-mail: zjcdcwxf@gmail.com [Zhejiang Provincial Center for Disease Control and Prevention, 630 Xin Cheng Road, Binjiang District, Hangzhou 310051 (China); Centre for Environment and Population Health, Griffith School of Environment, Griffith University, 170 Kessels Road, Nathan, QLD 4111 (Australia); Miller, Greg [Centre for Environment and Population Health, Griffith School of Environment, Griffith University, 170 Kessels Road, Nathan, QLD 4111 (Australia); Ding, Gangqiang; Lou, Xiaoming; Cai, Delei; Chen, Zhijian; Meng, Jia; Tang, Jun [Zhejiang Provincial Center for Disease Control and Prevention, 630 Xin Cheng Road, Binjiang District, Hangzhou 310051 (China); Chu, Cordia [Centre for Environment and Population Health, Griffith School of Environment, Griffith University, 170 Kessels Road, Nathan, QLD 4111 (Australia); Mo, Zhe; Han, Jianlong [Zhejiang Provincial Center for Disease Control and Prevention, 630 Xin Cheng Road, Binjiang District, Hangzhou 310051 (China)

    2012-06-01

    Tinfoil manufacturing and electronic waste (e-waste) recycling remain rudimentary processes in Zhejing Province, China, which could account for elevated blood lead levels (BLLs) and health impacts on children. We assessed the potential health risks of lead in tinfoil manufacturing and e-waste recycling areas. 329 children in total aged 11-12 who lived in a tinfoil manufacturing area (Lanxi), an e-waste recycling area (Luqiao) and a reference area (Chun'an) were studied. Lead levels in children's blood were determined by inductively coupled plasma mass spectrometer (ICP-MS). Blood urea nitrogen (BUN), serum creatinine, serum calcium, {delta}-Aminolaevulinic acid ({delta}-ALA) and intelligence quotient (IQ) were also measured. Geometric mean of BLLs in Lanxi, Luqiao and Chun'an were 8.11 {mu}g/dL, 6.97 {mu}g/dL, and 2.78 {mu}g/dL respectively, with 35.1%, 38.9% and 0% of children who had BLLs above 10 {mu}g/dL. The BLLs in exposed areas were much higher than those in the control area. Lanxi children had higher creatinine and calcium than Chun'an children, and Luqiao children had higher {delta}-ALA and lower calcium than Chun'an children. No significant differences of IQ were observed between Lanxi, Luqiao and Chun'an, however a negative relationship between BLLs and IQ was shown for the study children. The results indicated that lead pollution from e-waste recycling and tinfoil processing appears to be a potential serious threat to children's health. - Highlights: Black-Right-Pointing-Pointer No report on tinfoil processing impact on children's health before. Black-Right-Pointing-Pointer Few studies reported health impacts of lead from e-waste processing. Black-Right-Pointing-Pointer Children with blood lead levels < 10 {mu}g/dL are associated with a decrease in IQ. Black-Right-Pointing-Pointer Threshold appears to exist at blood lead level of about 20 {mu}g/dL for urinary {delta}-ALA.

  2. Human health risk assessment of heavy metals in tropical fish and shellfish collected from the river Buriganga, Bangladesh.

    Science.gov (United States)

    Ahmed, Md Kawser; Baki, Mohammad Abdul; Islam, Md Saiful; Kundu, Goutam Kumar; Habibullah-Al-Mamun, Md; Sarkar, Santosh Kumar; Hossain, Md Muzammel

    2015-10-01

    Although fish, crustacean, and shellfish are significant sources of protein, they are currently affected by rapid industrialization, resulting in increased concentrations of heavy metals. Accumulation of heavy metals (V, Cr, Mn, Ni, Cu, Zn, As, Se, Mo, Ag, Cd, Sb, Ba, and Pb) and associated human health risk were investigated in three fish species, namely Ailia coila, Gagata youssoufi, and Mastacembelus pancalus; one crustacean (prawn), Macrobrachium rosenbergii; and one Gastropoda, Indoplanorbis exustus, collected from the Buriganga River, Bangladesh. Samples were collected from the professional fishermen. Cu was the most accumulated metal in M. rosenbergii. Ni, As, Ag, and Sb were in relatively lower concentrations, whereas relatively higher accumulation of Cr, Mn, Zn, and Se were recorded. Mn, Zn, and Pb were present in higher concentrations than the guidelines of various authorities. There were significant differences in metal accumulation among different fish, prawn, or shellfish species. Target hazard quotient (THQ) and target cancer risk (TR) were calculated to estimate the non-carcinogenic and carcinogenic health risks, respectively. The THQ for individual heavy metals were below 1 suggesting no potential health risk. But combined impact, estimated by hazard index (HI), suggested health risk for M. pancalus consumption. Although consumption of fish at current accumulation level is safe but continuous and excess consumption for a life time of more than 70 years has probability of target cancer risk.

  3. Fate of Radium in Marcellus Shale Flowback Water Impoundments and Assessment of Associated Health Risks.

    Science.gov (United States)

    Zhang, Tieyuan; Hammack, Richard W; Vidic, Radisav D

    2015-08-01

    Natural gas extraction from Marcellus Shale generates large quantities of flowback water that contain high levels of salinity, heavy metals, and naturally occurring radioactive material (NORM). This water is typically stored in centralized storage impoundments or tanks prior to reuse, treatment or disposal. The fate of Ra-226, which is the dominant NORM component in flowback water, in three centralized storage impoundments in southwestern Pennsylvania was investigated during a 2.5-year period. Field sampling revealed that Ra-226 concentration in these storage facilities depends on the management strategy but is generally increasing during the reuse of flowback water for hydraulic fracturing. In addition, Ra-226 is enriched in the bottom solids (e.g., impoundment sludge), where it increased from less than 10 pCi/g for fresh sludge to several hundred pCi/g for aged sludge. A combination of sequential extraction procedure (SEP) and chemical composition analysis of impoundment sludge revealed that Barite is the main carrier of Ra-226 in the sludge. Toxicity characteristic leaching procedure (TCLP) (EPA Method 1311) was used to assess the leaching behavior of Ra-226 in the impoundment sludge and its implications for waste management strategies for this low-level radioactive solid waste. Radiation exposure for on-site workers calculated using the RESRAD model showed that the radiation dose equivalent for the baseline conditions was well below the NRC limit for the general public.

  4. Distribution and health risk assessment of organochlorine pesticides (OCPs) in industrial site soils: A case study of urban renewal in Beijing, China

    Institute of Scientific and Technical Information of China (English)

    YANG Wenrui; WANG Rusong; ZHOU Chuanbin; LI Feng

    2009-01-01

    A field survey was conducted in a contaminated industrial site in southern Beijing, China to investigate theconcentrations and distribution of the organochlorine pesticides (α-, β-, γ-, δ-HCH, p,p'-DDT, p,p'-DDE, p,p'-DDD and o,p'-DDT) in the profiles of soil, and a health risk assessment was carried out with CalTOX multimedia exposure model. Results showed that mean concentrations of total hexachlorocyclohexane isomers (HCHs) and total dichlorodiphenyltrichloroethane isomers (DDXs) in soils ranged in 13.19-148.71 mg/kg, and 3.02-67.42 mg/kg, respectively. Organochlorine pesticides (OCPs) concentration peaked at the surface and declined in soil profile with depth and the amounts of HCHs in three profiles of soil were larger than DDXs. Composition analysis indicated that there was a trend of degradation of OCPs in the site, but the mean of HCHs and DDXs concentration were over the state warning standard limit (HCHs, 0.50 mg/kg; DDXs, 0.50 mg/kg). According to current land use development, health risk assessment with CalTOX and Monte Carlo analysis showed that health risks mainly came from two exposure pathways: dermal uptake and inhalation, and that the total risk values all exceeded the general acceptable health risk value (10-6). The sensitivity analysis indicated that five parameters significantly contributed to total risk.

  5. Using Mode of Action to Assess Health Risks from Mixtures of Chemical/Physical Agents

    Energy Technology Data Exchange (ETDEWEB)

    Bull, Richard J.; Lei, Xingye C.; Sasser, Lyle B.

    2003-01-20

    Interactions between tumor promoters with differing mechanisms of action were examined in male B6C3F1 mice treated with mixtures of dichloroacetate (DCA), trichloroacetate (TCA), and tetrachloride (CT), each of which acts by a different mode of action. Mice were initiated by vinyl carbamate (VC), and then promoted by DCA, TCA, CT, or the pair-wised combinations of the three compounds. The effect of each treatment or treatment combination on tumor number/animal and tumor size was individually assessed at 18, 24, 30 or 36 weeks of treatment. Dose-related increases in tumor size were observed with 20 & 50 mg/kg CT, but each produced equal number of tumors at 36 weeks with the main distinction being a decrease in tumor latency at the higher dose. Overall TCA treatment produced dose-related increases in tumor number at 36 weeks of treatment. Thus, the lower doses of CT and TCA treatments apparently affected tumor size rather than number. Results with DCA were not as clear as a true maximum tumor number was not clearly observed within the experimental period. Treatment of mice receiving a high dose of TCA (2 g/L of drinking water) combined with varying doses of DCA (0.1, 0.5 and 2 g/L) produced increased numbers of tumors at 24 weeks and 36 weeks. However, at 36 weeks of treatment DCA produced a dose-related decrease in the size of tumors promoted by TCA. The low dose of TCA (0.1 g/L) decreased the number of tumors produced by a high dose of DCA, however, higher doses of TCA produced the same number as observed with DCA alone. Since these two chemicals produce lesions with differing phenotypes, the combination would have been expected to be additive with respect to number, but this was obviously not the case. These data suggest that the induction of liver cancer from mixtures of solvents may have predictable outcomes. The major conclusion is that these interactions are generally no more than additive. It was most interesting to note that additivity was only observed when

  6. What is needed to implement a computer-assisted health risk assessment tool? An exploratory concept mapping study

    Directory of Open Access Journals (Sweden)

    Ahmad Farah

    2012-12-01

    Full Text Available Abstract Background Emerging eHealth tools could facilitate the delivery of comprehensive care in time-constrained clinical settings. One such tool is interactive computer-assisted health-risk assessments (HRA, which may improve provider-patient communication at the point of care, particularly for psychosocial health concerns, which remain under-detected in clinical encounters. The research team explored the perspectives of healthcare providers representing a variety of disciplines (physicians, nurses, social workers, allied staff regarding the factors required for implementation of an interactive HRA on psychosocial health. Methods The research team employed a semi-qualitative participatory method known as Concept Mapping, which involved three distinct phases. First, in face-to-face and online brainstorming sessions, participants responded to an open-ended central question: “What factors should be in place within your clinical setting to support an effective computer-assisted screening tool for psychosocial risks?” The brainstormed items were consolidated by the research team. Then, in face-to-face and online sorting sessions, participants grouped the items thematically as ‘it made sense to them’. Participants also rated each item on a 5-point scale for its ‘importance’ and ‘action feasibility’ over the ensuing six month period. The sorted and rated data was analyzed using multidimensional scaling and hierarchical cluster analyses which produced visual maps. In the third and final phase, the face-to-face Interpretation sessions, the concept maps were discussed and illuminated by participants collectively. Results Overall, 54 providers participated (emergency care 48%; primary care 52%. Participants brainstormed 196 items thought to be necessary for the implementation of an interactive HRA emphasizing psychosocial health. These were consolidated by the research team into 85 items. After sorting and rating, cluster analysis

  7. Assessment and management of human health risk from toxic metals and polycyclic aromatic hydrocarbons in urban stormwater arising from anthropogenic activities and traffic congestion.

    Science.gov (United States)

    Ma, Yukun; Liu, An; Egodawatta, Prasanna; McGree, James; Goonetilleke, Ashantha

    2017-02-01

    Toxic metals (TMs) and polycyclic aromatic hydrocarbons (PAHs) in urban stormwater pose risk to human health, thereby constraining its reuse potential. Based on the hypothesis that stormwater quality is primarily influenced by anthropogenic activities and traffic congestion, the primary focus of the research study was to analyse the impacts on human health risk from TMs and PAHs in urban stormwater and thereby develop a quantitative risk assessment model. The study found that anthropogenic activities and traffic congestion exert influence on the risk posed by TMs and PAHs in stormwater from commercial and residential areas. Motor vehicle related businesses (FVS) and traffic congestion (TC) were identified as two parameters which need to be included as independent variables to improve the model. Based on the study outcomes, approaches for mitigating the risk associated with TMs and PAHs in urban stormwater are discussed. Additionally, a roadmap is presented for the assessment and management of the risk arising from these pollutants. The study outcomes are expected to contribute to reducing the human health risk associated urban stormwater pollution and thereby enhance its reuse potential.

  8. Heart Rate Variability: New Perspectives on Physiological Mechanisms, Assessment of Self-regulatory Capacity, and Health risk.

    Science.gov (United States)

    McCraty, Rollin; Shaffer, Fred

    2015-01-01

    Heart rate variability, the change in the time intervals between adjacent heartbeats, is an emergent property of interdependent regulatory systems that operates on different time scales to adapt to environmental and psychological challenges. This article briefly reviews neural regulation of the heart and offers some new perspectives on mechanisms underlying the very low frequency rhythm of heart rate variability. Interpretation of heart rate variability rhythms in the context of health risk and physiological and psychological self-regulatory capacity assessment is discussed. The cardiovascular regulatory centers in the spinal cord and medulla integrate inputs from higher brain centers with afferent cardiovascular system inputs to adjust heart rate and blood pressure via sympathetic and parasympathetic efferent pathways. We also discuss the intrinsic cardiac nervous system and the heart-brain connection pathways, through which afferent information can influence activity in the subcortical, frontocortical, and motor cortex areas. In addition, the use of real-time HRV feedback to increase self-regulatory capacity is reviewed. We conclude that the heart's rhythms are characterized by both complexity and stability over longer time scales that reflect both physiological and psychological functional status of these internal self-regulatory systems.

  9. Semi-Quantitative Assessment of the Health Risk of Occupational Exposure to Chemicals and Evaluation of Spirometry Indices on the Staff of Petrochemical Industry

    Directory of Open Access Journals (Sweden)

    Hajar Dazi

    2017-01-01

    Full Text Available Background & Aims of the Study: Petrochemical industry is an important industry in the economic development of the country that causes employees have exposure with several kinds of contamination. The aim of this study was Semi-quantitative assessment of the health risk of occupational exposure to chemical materials and investigation of spirometry indices between employees of petrochemical industry. Material & Methods: This cross-sectional study was conducted in one of the petrochemical industry complex in a special area of Assaluyeh in Iran in 2016. Health risk assessment of exposure to harmful chemical agents was performed in all of units and during three stages (identification of harmful material, determination of hazard rate of the chemical material, exposure rate and estimate of risk rate. Spirometry indices were measured using spirometry. Results: The results of chemical materials risk assessment showed that Raffinate in Butadiene unit has identified the highest amount of risk rank among 27 chemical materials in investigated units. In comparison with spirometry indices in Olefine unit between age with FVC parameter and history work with FVC and FEV1 parameters has observed a significant and negative correlation (P<0.05. Conclusion: The results of risk assessment in all of the petrochemical units showed that 48.14% of materials were at low risk level, 29.62% medium risk, 18.51% high risk and 3.7% had very high risk level. The variables affecting on spirometry employees such as age and work experience play an important role in reducing the pulmonary function tests in exposed subjects.

  10. Long-term fate of depleted uranium at Aberdeen and Yuma Proving Grounds: Human health and ecological risk assessments

    Energy Technology Data Exchange (ETDEWEB)

    Ebinger, M.H.; Beckman, R.J.; Myers, O.B. [Los Alamos National Lab., NM (United States); Kennedy, P.L.; Clements, W.; Bestgen, H.T. [Colorado State Univ., Ft. Collins, CO (United States). Dept. of Fishery and Wildlife Biology

    1996-09-01

    The purpose of this study was to evaluate the immediate and long-term consequences of depleted uranium (DU) in the environment at Aberdeen Proving Ground (APG) and Yuma Proving Ground (YPG) for the Test and Evaluation Command (TECOM) of the US Army. Specifically, we examined the potential for adverse radiological and toxicological effects to humans and ecosystems caused by exposure to DU at both installations. We developed contaminant transport models of aquatic and terrestrial ecosystems at APG and terrestrial ecosystems at YPG to assess potential adverse effects from DU exposure. Sensitivity and uncertainty analyses of the initial models showed the portions of the models that most influenced predicted DU concentrations, and the results of the sensitivity analyses were fundamental tools in designing field sampling campaigns at both installations. Results of uranium (U) isotope analyses of field samples provided data to evaluate the source of U in the environment and the toxicological and radiological doses to different ecosystem components and to humans. Probabilistic doses were estimated from the field data, and DU was identified in several components of the food chain at APG and YPG. Dose estimates from APG data indicated that U or DU uptake was insufficient to cause adverse toxicological or radiological effects. Dose estimates from YPG data indicated that U or DU uptake is insufficient to cause radiological effects in ecosystem components or in humans, but toxicological effects in small mammals (e.g., kangaroo rats and pocket mice) may occur from U or DU ingestion. The results of this study were used to modify environmental radiation monitoring plans at APG and YPG to ensure collection of adequate data for ongoing ecological and human health risk assessments.

  11. Plastics and health risks.

    Science.gov (United States)

    Halden, Rolf U

    2010-01-01

    By 2010, the worldwide annual production of plastics will surpass 300 million tons. Plastics are indispensable materials in modern society, and many products manufactured from plastics are a boon to public health (e.g., disposable syringes, intravenous bags). However, plastics also pose health risks. Of principal concern are endocrine-disrupting properties, as triggered for example by bisphenol A and di-(2-ethylhexyl) phthalate (DEHP). Opinions on the safety of plastics vary widely, and despite more than five decades of research, scientific consensus on product safety is still elusive. This literature review summarizes information from more than 120 peer-reviewed publications on health effects of plastics and plasticizers in lab animals and humans. It examines problematic exposures of susceptible populations and also briefly summarizes adverse environmental impacts from plastic pollution. Ongoing efforts to steer human society toward resource conservation and sustainable consumption are discussed, including the concept of the 5 Rs--i.e., reduce, reuse, recycle, rethink, restrain--for minimizing pre- and postnatal exposures to potentially harmful components of plastics.

  12. Recovery in environmental risk assessment at EFSA

    NARCIS (Netherlands)

    Brock, T.C.M.

    2016-01-01

    EFSA performs environmental risk assessments (ERAs) for single potential stressors such as plant protection products, genetically modified organisms and feed additives and for invasive alien species that are harmful for plant health. In this risk assessment domain, the EFSA Scientific Committee reco

  13. Assessment of Industry-Induced Urban Human Health Risks Related to Benzo[a]pyrenebased on a Multimedia Fugacity Model: Case Study of Nanjing, China.

    Science.gov (United States)

    Xu, Linyu; Song, Huimin; Wang, Yan; Yin, Hao

    2015-05-29

    Large amounts of organic pollutants emitted from industries have accumulated and caused serious human health risks, especially in urban areas with rapid industrialization. This paper focused on the carcinogen benzo[a]pyrene (BaP) from industrial effluent and gaseous emissions, and established a multi-pathway exposure model based on a Level IV multimedia fugacity model to analyze the human health risks in a city that has undergone rapid industrialization. In this study, GIS tools combined with land-use data was introduced to analyze smaller spatial scales so as to enhance the spatial resolution of the results. An uncertainty analysis using a Monte Carlo simulation was also conducted to illustrate the rationale of the probabilistic assessment mode rather than deterministic assessment. Finally, the results of the case study in Nanjing, China indicated the annual average human cancer risk induced by local industrial emissions during 2002-2008 (lowest at 1.99x10(-6) in 2008 and highest at 3.34x10(-6) in 2004), which was lower than the USEPA prescriptive level (1x10(-6)-1x10(-4)) but cannot be neglected in the long term. The study results could not only instruct the BaP health risk management but also help future health risk prediction and control.

  14. Assessment of Industry-Induced Urban Human Health Risks Related to Benzo[a]pyrene based on a Multimedia Fugacity Model: Case Study of Nanjing, China

    Directory of Open Access Journals (Sweden)

    Linyu Xu

    2015-05-01

    Full Text Available Large amounts of organic pollutants emitted from industries have accumulated and caused serious human health risks, especially in urban areas with rapid industrialization. This paper focused on the carcinogen benzo[a]pyrene (BaP from industrial effluent and gaseous emissions, and established a multi-pathway exposure model based on a Level IV multimedia fugacity model to analyze the human health risks in a city that has undergone rapid industrialization. In this study, GIS tools combined with land-use data was introduced to analyze smaller spatial scales so as to enhance the spatial resolution of the results. An uncertainty analysis using a Monte Carlo simulation was also conducted to illustrate the rationale of the probabilistic assessment mode rather than deterministic assessment. Finally, the results of the case study in Nanjing, China indicated the annual average human cancer risk induced by local industrial emissions during 2002–2008 (lowest at 1.99´10–6 in 2008 and highest at 3.34´10–6 in 2004, which was lower than the USEPA prescriptive level (1´10–6–1´10–4 but cannot be neglected in the long term. The study results could not only instruct the BaP health risk management but also help future health risk prediction and control.

  15. Source contribution and risk assessment of airborne toxic metals by neutron activation analysis in Taejeon industrial complex area - Concentration analysis and health risk assessment of airborne toxic metals in Taejeon 1,2 industrial Complex

    Energy Technology Data Exchange (ETDEWEB)

    Lee, J. H.; Jang, M. S.; Nam, B. H.; Yun, M. J. [Chungnam National Univ., Taejeon (Korea)

    2000-04-01

    The study centers on one-year continual concentration analysis using ICP-MS and on health risk assessment of 15 airborne toxic metals in Taejeon 1,2 industrial complex. About 1-year arithmetic mean of human carcinogen, arsenic, hexavalent chromium and nickel subsulfide is 6.05, 2.40 and 2.81 ng/m{sup 3} while the mean of probable human carcinogen, beryllium, cadmium and lead is 0.06, 3.92, 145.99 ng/m{sup 3}, respectively. And the long-term arithmetic mean concentration of non-carcinogenic metal, manganese is 44.60 ng/m{sup 3}. The point risk estimate for the inhalation of carcinogenic metals is 7.0 X10{sup -5}, which is higher than a risk standard of 10{sup -5}. The risk from human carcinogens is 6.2X10{sup -5}, while that from probable human carcinogens is 8.0X10{sup -6}, respectively. About 86 % of the cancer risk is due to the inhalation of human carcinogens, arsenic and hexavalent chromium. Thus, it is necessary to properly manage both arsenic and hexavalent chromium risk in Taejeon 1,2 industrial complex. 37 refs., 13 figs., 9 tabs. (Author)

  16. Bioaccessibility and health risk assessment of arsenic in soil and indoor dust in rural and urban areas of Hubei province, China.

    Science.gov (United States)

    Liu, Yanzhong; Ma, Junwei; Yan, Hongxia; Ren, Yuqing; Wang, Beibei; Lin, Chunye; Liu, Xitao

    2016-04-01

    Incidental oral ingestion is the main exposure pathway by which human intake contaminants in both soil and indoor dust, and this is especially true for children as they frequently exhibit hand-to-mouth behaviour. Research on comprehensive health risk caused by incidental ingestion of both soil and indoor dust is limited. The aims of this study were to investigate the arsenic concentration and to characterize the health risks due to arsenic (As) exposure via soil and indoor dust in rural and urban areas of Hubei province within central China. Soil and indoor dust samples were collected from schools and residential locations and bioaccessibility of arsenic in these samples was determined by a simplified bioaccessibility extraction test (SBET). The total arsenic content in indoor dust samples was 1.78-2.60 times that measured in soil samples. The mean As bioaccessibility ranged from 75.4% to 83.2% in indoor dust samples and from 13.8% to 20.2% in soil samples. A Pearson's analysis showed that As bioaccessibility was significantly correlated with Fe and Al in soil and indoor dust, respectively, and activity patterns of children were utilised in the assessment of health risk via incidental ingestion of soil and indoor dust. The results suggest no non-carcinogenic health risks (HQ<1) or acceptable carcinogenic health risks (1×10(-6)health risk incurred during daily indoor and outdoor activities. The HQ and CR values for children in urban areas were 1.59-1.95 times those for children in rural areas. The HQ and CR values for children three to five years of age were 1.40-1.47 times those for children six to nine years of age. The health risk accounting for bioaccessibility was only 50.8-59.8% of that obtained without consideration of bioaccessibility.

  17. The Wild Wild West: A Framework to Integrate mHealth Software Applications and Wearables to Support Physical Activity Assessment, Counseling and Interventions for Cardiovascular Disease Risk Reduction.

    Science.gov (United States)

    Lobelo, Felipe; Kelli, Heval M; Tejedor, Sheri Chernetsky; Pratt, Michael; McConnell, Michael V; Martin, Seth S; Welk, Gregory J

    2016-01-01

    Physical activity (PA) interventions constitute a critical component of cardiovascular disease (CVD) risk reduction programs. Objective mobile health (mHealth) software applications (apps) and wearable activity monitors (WAMs) can advance both assessment and integration of PA counseling in clinical settings and support community-based PA interventions. The use of mHealth technology for CVD risk reduction is promising, but integration into routine clinical care and population health management has proven challenging. The increasing diversity of available technologies and the lack of a comprehensive guiding framework are key barriers for standardizing data collection and integration. This paper reviews the validity, utility and feasibility of implementing mHealth technology in clinical settings and proposes an organizational framework to support PA assessment, counseling and referrals to community resources for CVD risk reduction interventions. This integration framework can be adapted to different clinical population needs. It should also be refined as technologies and regulations advance under an evolving health care system landscape in the United States and globally.

  18. The Wild Wild West: A Framework to Integrate mHealth Software Applications and Wearables to Support Physical Activity Assessment, Counseling and Interventions for Cardiovascular Disease Risk Reduction

    Science.gov (United States)

    Lobelo, Felipe; Kelli, Heval M.; Tejedor, Sheri Chernetsky; Pratt, Michael; McConnell, Michael V.; Martin, Seth S.; Welk, Gregory J.

    2017-01-01

    Physical activity (PA) interventions constitute a critical component of cardiovascular disease (CVD) risk reduction programs. Objective mobile health (mHealth) software applications (apps) and wearable activity monitors (WAMs) can advance both assessment and integration of PA counseling in clinical settings and support community-based PA interventions. The use of mHealth technology for CVD risk reduction is promising, but integration into routine clinical care and population health management has proven challenging. The increasing diversity of available technologies and the lack of a comprehensive guiding framework are key barriers for standardizing data collection and integration. This paper reviews the validity, utility and feasibility of implementing mHealth technology in clinical settings and proposes an organizational framework to support PA assessment, counseling and referrals to community resources for CVD risk reduction interventions. This integration framework can be adapted to different clinical population needs. It should also be refined as technologies and regulations advance under an evolving health care system landscape in the United States and globally. PMID:26923067

  19. Novel Method for Recruiting Representative At-Risk Individuals into Cancer Prevention Trials: Online Health Risk Assessment in Employee Wellness Programs.

    Science.gov (United States)

    Hui, Siu-Kuen Azor; Miller, Suzanne M; Hazuda, Leah; Engelman, Kimberly; Ellerbeck, Edward F

    2016-09-01

    Participation in cancer prevention trials (CPT) is lower than 3 % among high-risk healthy individuals, and racial/ethnic minorities are the most under-represented. Novel recruitment strategies are therefore needed. Online health risk assessment (HRA) serves as a gateway component of nearly all employee wellness programs (EWPs) and may be a missed opportunity. This study aimed to explore employees' interest, willingness, motivators, and barriers of releasing their HRA responses to an external secure research database for recruitment purpose. We used qualitative research methods (focus group and individual interviews) to examine employees' interest and willingness in releasing their online HRA responses to an external, secure database to register as potential CPT participants. Fifteen structured interviews (40 % of study participants were of racial/ethnic minority) were conducted, and responses reached saturation after four interviews. All employees showed interest and willingness to release their online HRA responses to register as a potential CPT participant. Content analyses revealed that 91 % of participants were motivated to do so, and the major motivators were to (1) obtain help in finding personally relevant prevention trials, (2) help people they know who are affected by cancer, and/or (3) increase knowledge about CPT. A subset of participants (45 %) expressed barriers of releasing their HRA responses due to concerns about credibility and security of the external database. Online HRA may be a feasible but underutilized recruitment method for cancer prevention trials. EWP-sponsored HRA shows promise for the development of a large, centralized registry of racially/ethnically representative CPT potential participants.

  20. Risk communication, risk perception, and public health.

    Science.gov (United States)

    Aakko, Eric

    2004-01-01

    Risk communication is about building trust while deploying an interactive and ongoing communication process in which audience members are active participants. This interactive participation may not solve a public health crisis, but it will help reduce unwarranted fear, anxiety and distrust. Consequently, if a government agency fails to understand how to effectively communicate about health risks, their trustworthiness and credibility may suffer, and a crisis event may go from bad to worse.

  1. Review of assessments of the human health risk associated with the use of antimicrobial agents in agriculture.

    Science.gov (United States)

    Bailar, John C; Travers, Karin

    2002-06-01

    To our knowledge, no comprehensive risk assessment of agricultural uses of antimicrobial agents has been published. The published risk assessments of antimicrobial use in farm settings are all subject to multiple, serious limitations in scope, including (1) limitation to one species of microorganism; (2) limitation to one or a very few related antimicrobial agents; (3) limitation to a single outcome (death, hospital days, number of illnesses, etc.); (4) limitation to one species of farm animal (e.g., chicken or swine); and (5) limitation to therapeutic use, despite reason for concern about misstated, off-label, or illegal use. In addition, all of the risk assessments reviewed overlooked important issues by accepting 2 further limitations: (6) limiting the scope of the analysis to what has already happened and ignoring the effects of continuing the practices of recent years; and (7) examining only the effects on the species of microorganism that was initially affected and ignoring the cross-species spread of resistance by plasmid transfer. After our review of the risk assessments now available, we propose a comprehensive scheme for organizing existing knowledge and dealing with critical gaps.

  2. Conflicts of interests, confidentiality and censorship in health risk assessment: the example of an herbicide and a GMO.

    Science.gov (United States)

    Séralini, Gilles-Eric; Mesnage, Robin; Defarge, Nicolas; Spiroux de Vendômois, Joël

    2014-01-01

    We have studied the long-term toxicity of a Roundup-tolerant GM maize (NK603) and a whole Roundup pesticide formulation at environmentally relevant levels from 0.1 ppb. Our study was first published in Food and Chemical Toxicology (FCT) on 19 September, 2012. The first wave of criticisms arrived within a week, mostly from plant biologists without experience in toxicology. We answered all these criticisms. The debate then encompassed scientific arguments and a wave of ad hominem and potentially libellous comments appeared in different journals by authors having serious yet undisclosed conflicts of interests. At the same time, FCT acquired as its new assistant editor for biotechnology a former employee of Monsanto after he sent a letter to FCT to complain about our study. This is in particular why FCT asked for a post-hoc analysis of our raw data. On 19 November, 2013, the editor-in-chief requested the retraction of our study while recognizing that the data were not incorrect and that there was no misconduct and no fraud or intentional misinterpretation in our complete raw data - an unusual or even unprecedented action in scientific publishing. The editor argued that no conclusions could be drawn because we studied 10 rats per group over 2 years, because they were Sprague Dawley rats, and because the data were inconclusive on cancer. Yet this was known at the time of submission of our study. Our study was however never attended to be a carcinogenicity study. We never used the word 'cancer' in our paper. The present opinion is a summary of the debate resulting in this retraction, as it is a historic example of conflicts of interest in the scientific assessments of products commercialized worldwide. We also show that the decision to retract cannot be rationalized on any discernible scientific or ethical grounds. Censorship of research into health risks undermines the value and the credibility of science; thus, we republish our paper.

  3. In situ remediation-released zero-valent iron nanoparticles impair soil ecosystems health: A C. elegans biomarker-based risk assessment.

    Science.gov (United States)

    Yang, Ying-Fei; Cheng, Yi-Hsien; Liao, Chung-Min

    2016-11-01

    There is considerable concern over the potential ecotoxicity to soil ecosystems posed by zero-valent iron nanoparticles (Fe(0) NPs) released from in situ environmental remediation. However, a lack of quantitative risk assessment has hampered the development of appropriate testing methods used in environmental applications. Here we present a novel, empirical approach to assess Fe(0) NPs-associated soil ecosystems health risk using the nematode Caenorhabditis elegans as a model organism. A Hill-based dose-response model describing the concentration-fertility inhibition relationships was constructed. A Weibull model was used to estimate thresholds as a guideline to protect C. elegans from infertility when exposed to waterborne or foodborne Fe(0) NPs. Finally, the risk metrics, exceedance risk (ER) and risk quotient (RQ) of Fe(0) NPs in various depths and distances from remediation sites can then be predicted. We showed that under 50% risk probability (ER=0.5), upper soil layer had the highest infertility risk (95% confidence interval: 13.18-57.40%). The margins of safety and acceptable criteria for soil ecosystems health for using Fe(0) NPs in field scale applications were also recommended. Results showed that RQs are larger than 1 in all soil layers when setting a stricter threshold of ∼1.02mgL(-1) of Fe(0) NPs. This C. elegans biomarker-based risk model affords new insights into the links between widespread use of Fe(0) NPs and environmental risk assessment and offers potential environmental implications of metal-based NPs for in situ remediation.

  4. NON-CANCER HUMAN HEALTH RISK ASSESSMENT FROM EXPOSURE TO HEAVY METALS IN SURFACE AND GROUNDWATER IN IGUN IJESHA, SOUTHWEST NIGERIA

    Directory of Open Access Journals (Sweden)

    O. O. Ayantobo

    2014-01-01

    Full Text Available Non-cancer hazard index for inhabitants exposed to heavy metals in surface and groundwater of the abandoned metal mine in Igun-Ijesha area were evaluated. A total of thirty-eight water samples were collected from surface and ground water sources in the study area between September 2012 and February 2013 and the concentrations of heavy metals were determined using Atomic Absorption Spectrophotometer. Non-cancer risk assessments from possible exposure to heavy metals were evaluated using the United States Environmental Protection Agency’s human health risk assessment guidelines. Simple random sampling was used to administer questionnaires to investigate demographic characteristics and public health status of residents. Data obtained were subjected to descriptive statistics and ANOVA using SPSS for Windows version 16. Results indicated elevated levels of Cadmium (Cd, Chromium (Cr, Copper (Cu, lead (Pb, Manganese (Mn, Nickel (Ni and Zinc (Zn ranging from 0.01-1.20, 0.05-0.52, 0.80-34.80, 0.09-4.30, 0.09-8.30, 0.05-3.94, 0.05-19.60 and 1.80-29.90 mg L-1 respectively which exceeded national recommended limits with few exceptions. Hazard Quotients (HQ and Hazard Index (HI of heavy metals were calculated and results greater than 1 indicate non-carcinogenic adverse health effects of the observed metals. A daily intake of water by the local residents could pose a potential health threat from long-term heavy-metal exposure. The risk assessment provided by this study can be beneficially used and applied for risk communication to avoid negative public health impact. Similarly, Water Safety quality assurance strategic plan should be developed to safeguard source, water and public health within the mining community.

  5. Surgery Risk Assessment (SRA) Database

    Data.gov (United States)

    Department of Veterans Affairs — The Surgery Risk Assessment (SRA) database is part of the VA Surgical Quality Improvement Program (VASQIP). This database contains assessments of selected surgical...

  6. Metal uptake by homegrown vegetables – The relative importance in human health risk assessments at contaminated sites

    Energy Technology Data Exchange (ETDEWEB)

    Augustsson, Anna L.M., E-mail: anna.augustsson@lnu.se [Department of Biology and Environmental Science, Linnaeus University, SE-391 82 Kalmar (Sweden); Uddh-Söderberg, Terese E. [Department of Biology and Environmental Science, Linnaeus University, SE-391 82 Kalmar (Sweden); Hogmalm, K. Johan [Department of Earth Sciences, University of Gothenburg, Gothenburg (Sweden); Filipsson, Monika E.M. [Department of Biology and Environmental Science, Linnaeus University, SE-391 82 Kalmar (Sweden)

    2015-04-15

    Risk assessments of contaminated land often involve the use of generic bioconcentration factors (BCFs), which express contaminant concentrations in edible plant parts as a function of the concentration in soil, in order to assess the risks associated with consumption of homegrown vegetables. This study aimed to quantify variability in BCFs and evaluate the implications of this variability for human exposure assessments, focusing on cadmium (Cd) and lead (Pb) in lettuce and potatoes sampled around 22 contaminated glassworks sites. In addition, risks associated with measured Cd and Pb concentrations in soil and vegetable samples were characterized and a probabilistic exposure assessment was conducted to estimate the likelihood of local residents exceeding tolerable daily intakes. The results show that concentrations in vegetables were only moderately elevated despite high concentrations in soil, and most samples complied with applicable foodstuff legislation. Still, the daily intake of Cd (but not Pb) was assessed to exceed toxicological thresholds for about a fifth of the study population. Bioconcentration factors were found to vary more than indicated by previous studies, but decreasing BCFs with increasing metal concentrations in the soil can explain why the calculated exposure is only moderately affected by the choice of BCF value when generic soil guideline values are exceeded and the risk may be unacceptable. - Highlights: • Uptake of Cd and Pb by lettuce and potatoes increased with soil contamination. • Consumption of homegrown vegetables may lead to a daily Cd intake above TDIs. • The variability in the calculated BCFs is high when compared to previous studies. • Exposure assessments are most sensitive to the choice of BCFs at low contamination.

  7. Risk assessment of parents' concerns at 18 months in preventive child health care predicted child abuse and neglect

    NARCIS (Netherlands)

    I.I.E. Staal; J.M.A. Hermanns; A.J.P. Schrijvers; H.F. van Stel

    2013-01-01

    Objective: As child maltreatment has a major impact, prevention and early detection of parenting problems are of great importance. We have developed a structured interview which uses parents’ concerns for a joint needs assessment by parents and a child health care nurse, followed by a professional j

  8. Human health risk assessment of heavy metals via consumption of contaminated vegetables collected from different irrigation sources in Lahore, Pakistan

    Directory of Open Access Journals (Sweden)

    Adeel Mahmood

    2014-01-01

    Full Text Available Soil pollution with heavy metals due to discharge of untreated urban and industrial wastewater is a major threat to ecological integrity and human well-being. The presenting study aimed to determine human health risks associated via food chain contamination of heavy metals routing from irrigation of urban and industrial wastewater. Irrigated water, soil and vegetables were analyzed for Cr2+, Co2+, Ni2+, Cu2+, Pb2+, Cd2+, Mn2+ and Zn2+; transfer factor (TF, daily intake of metals (DIM and health risk index (HRI were also calculated. Cr2+, Pb2+ and Cd2+ in vegetables cultivated by wastewater exceeded the permissible limits (European Union, 2002 while TF was lower for all metals except Co2+ and HRI was found to be maximum for Spinacia oleracea (2.42 mg/kg and Brassica campestris (2.22 mg/kg cultivated by wastewater. S. oleracea, B. campestris, Coriandrum sativum posed a severe health risk with respect to Cd and Mn.

  9. Risk assessment of plant protection products

    Directory of Open Access Journals (Sweden)

    Hardy T

    2012-10-01

    Full Text Available

    EFSA’s Panel on Plant Protection Products and their Residues (PPR Panel provides independent scientific advice in the field of risk assessment of plant protection products (PPPs, pesticides. Since its establishment in 2003 under Regulation (EC No 178/2002, it has delivered a series of scientific outputs in support of evaluation of pesticide active substances, establishing scientific principles and guidance documents in the field of pesticide risk assessment and in support of decision making of European Union (EU law makers. Next to a series of scientific opinions evaluating specific adverse effects of PPPs for human health (like for instance carcinogenicity the Panel also delivered scientific opinions on general principles in the field of human health risk assessment (like reference value setting and is, in particular over the last years, very much engaged in development of methodologies to meet new challenges in regulatory risk assessments such as assessment of toxicity of pesticide metabolites and potential cumulative effects of pesticides to human health. Fate, behaviour and transformation of pesticides after their application and consequent release to the environment are a major aspect of pesticide risk assessment. The PPR Panel has achieved major accomplishments by delivering guidance and scientific opinions on degradation in soil, exposure of soil organisms and assessment of environmental risks by use of pesticides in greenhouses or grown under cover. A series of scientific opinions have been delivered also in the field of environmental risk assessment of pesticides. Scientific output covered specific issues arising in the peer review of specific active substances, revision of data requirements, development of risk assessment methodologies and the development of guidance documents. A major milestone of the PPR Panel was the development of the methodological framework for deriving specific protection goals for environmental risk

  10. [Health risks of oral contraceptives].

    Science.gov (United States)

    Meier, Christoph R

    2011-06-01

    smoking is also an important contributing factor to an increased VTE risk for women using OC. It is important that doctors and pharmacists inform new users of OC about potential health risks of OC use, and that the personal and family history of previous health risks is assessed thoroughly in order to rule out that important and relevant contraindications are present when a women starts taking OC.

  11. A methodology of the assessment of environmental and human health risks from amine emissions from post combustion CO2 capture technology

    Science.gov (United States)

    Korre, Anna; Manzoor, Saba; Simperler, Alexandra

    2015-04-01

    Post combustion CO2 capture (PCCC) technology in power plants using amines as solvent for CO2 capture, is one of the reduction technologies employed to combat escalating levels of CO2 in the atmosphere. However, amine solvents used for capturing CO2 produce negative emissions such as, nitrosamines and nitramines, which are suspected to be potent carcinogens. It is therefore essential to assess the atmospheric fate of these amine emissions in the atmosphere by studying their atmospheric chemistry, dispersion and transport pathways away from the source and deposition in the environment, so as to be able to assess accurately the risk posed to human health and the natural environment. An important knowledge gap until recently has been the consideration of the atmospheric chemistry of these amine emissions simultaneously with dispersion and deposition studies so as to perform reliable human health and environmental risk assessments. The authors have developed a methodology to assess the distribution of such emissions away from a post-combustion facility by studying the atmospheric chemistry of monoethanolamine, the most commonly used solvent for CO2 capture, and those of the resulting degradation amines, methylamine and dimethylamine. This was coupled with dispersion modeling calculations (Manzoor, et al., 2014; Manzoor et al,2015). Rate coefficients describing the entire atmospheric chemistry schemes of the amines studied were evaluated employing quantum chemical theoretical and kinetic modeling calculations. These coefficients were used to solve the advection-dispersion-chemical equation using an atmospheric dispersion model, ADMS 5. This methodology is applicable to any size of a power plant and at any geographical location. In this paper, the humman health risk assessment is integrated in the modelling study. The methodology is demonstrated on a case study on the UK's largest capture pilot plant, Ferrybridge CCPilot 100+, to estimate the dispersion, chemical

  12. Systems Toxicology: The Future of Risk Assessment.

    Science.gov (United States)

    Sauer, John Michael; Hartung, Thomas; Leist, Marcel; Knudsen, Thomas B; Hoeng, Julia; Hayes, A Wallace

    2015-01-01

    Risk assessment, in the context of public health, is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. With increasing public health concern regarding the potential risks associated with chemical exposure, there is a need for more predictive and accurate approaches to risk assessment. Developing such an approach requires a mechanistic understanding of the process by which xenobiotic substances perturb biological systems and lead to toxicity. Supplementing the shortfalls of traditional risk assessment with mechanistic biological data has been widely discussed but not routinely implemented in the evaluation of chemical exposure. These mechanistic approaches to risk assessment have been generally referred to as systems toxicology. This Symposium Overview article summarizes 4 talks presented at the 35th Annual Meeting of the American College of Toxicology.

  13. Risk assessment and risk management of mycotoxins.

    Science.gov (United States)

    2012-01-01

    Risk assessment is the process of quantifying the magnitude and exposure, or probability, of a harmful effect to individuals or populations from certain agents or activities. Here, we summarize the four steps of risk assessment: hazard identification, dose-response assessment, exposure assessment, and risk characterization. Risk assessments using these principles have been conducted on the major mycotoxins (aflatoxins, fumonisins, ochratoxin A, deoxynivalenol, and zearalenone) by various regulatory agencies for the purpose of setting food safety guidelines. We critically evaluate the impact of these risk assessment parameters on the estimated global burden of the associated diseases as well as the impact of regulatory measures on food supply and international trade. Apart from the well-established risk posed by aflatoxins, many uncertainties still exist about risk assessments for the other major mycotoxins, often reflecting a lack of epidemiological data. Differences exist in the risk management strategies and in the ways different governments impose regulations and technologies to reduce levels of mycotoxins in the food-chain. Regulatory measures have very little impact on remote rural and subsistence farming communities in developing countries, in contrast to developed countries, where regulations are strictly enforced to reduce and/or remove mycotoxin contamination. However, in the absence of the relevant technologies or the necessary infrastructure, we highlight simple intervention practices to reduce mycotoxin contamination in the field and/or prevent mycotoxin formation during storage.

  14. Groundwater contamination by microbiological and chemical substances released from hospital wastewater: health risk assessment for drinking water consumers.

    Science.gov (United States)

    Emmanuel, Evens; Pierre, Marie Gisèle; Perrodin, Yves

    2009-05-01

    Contamination of natural aquatic ecosystems by hospital wastewater is a major environmental and human health issue. Disinfectants, pharmaceuticals, radionuclides and solvents are widely used in hospitals for medical purposes and research. After application, some of these substances combine with hospital effluents and, in industrialised countries, reach the municipal sewer network. In certain developing countries, hospitals usually discharge their wastewater into septic tanks equipped with diffusion wells. The discharge of chemical compounds from hospital activities into the natural environment can lead to the pollution of water resources and risks for human health. The aim of this article is to present: (i) the steps of a procedure intended to evaluate risks to human health linked to hospital effluents discharged into a septic tank equipped with a diffusion well; and (ii) the results of its application on the effluents of a hospital in Port-au-Prince. The procedure is based on a scenario that describes the discharge of hospital effluents, via septic tanks, into a karstic formation where water resources are used for human consumption. COD, Chloroform, dichlomethane, dibromochloromethane, dichlorobromomethane and bromoform contents were measured. Furthermore, the presence of heavy metals (chrome, nickel and lead) and faecal coliforms were studied. Maximum concentrations were 700 NPP/100 ml for faecal coliforms and 112 mg/L for COD. A risk of infection of 10(-5) infection per year was calculated. Major chemical risks, particularly for children, relating to Pb(II), Cr(III), Cr(VI) and Ni(II) contained in the ground water were also characterised. Certain aspects of the scenario studied require improvement, especially those relating to the characterisation of drugs in groundwater and the detection of other microbiological indicators such as protozoa, enterococcus and viruses.

  15. Environmental levels of PCDD/Fs and metals around a cement plant in Catalonia, Spain, before and after alternative fuel implementation. Assessment of human health risks.

    Science.gov (United States)

    Rovira, Joaquim; Nadal, Martí; Schuhmacher, Marta; Domingo, José L

    2014-07-01

    The concentrations of As, Cd, Co, Cr, Cu, Hg, Mn, Ni, Pb, Sb, Sn, Tl, V, and Zn, and the levels of polychlorinated dibenzo-p-dioxins and dibenzofurans were determined in samples of soil, vegetation, and air, collected in the vicinity of a cement plant (Catalonia, Spain), before (January 2011 and July 2011) and after (January 2012 and June 2013) alternative fuel partial substitution (fossil fuels by sewage sludge). Seven sampling points were selected at different directions and distances to the facility including two background sampling points. The results were used to assess the health risk assessment for the population living near the facility. Only few significant differences were found before and after alternative fuel partial substitution (Mn in soils and Cd in vegetation). Non-carcinogenic risks were below the safety threshold (HQ<1), while carcinogenic risks were below 10(-5), or exceeding slightly that value, always in the range considered as assumable (10(-6)-10(-4)).

  16. The DYNAMO-HIA model: an efficient implementation of a risk factor/chronic disease Markov model for use in Health Impact Assessment (HIA).

    Science.gov (United States)

    Boshuizen, Hendriek C; Lhachimi, Stefan K; van Baal, Pieter H M; Hoogenveen, Rudolf T; Smit, Henriette A; Mackenbach, Johan P; Nusselder, Wilma J

    2012-11-01

    In Health Impact Assessment (HIA), or priority-setting for health policy, effects of risk factors (exposures) on health need to be modeled, such as with a Markov model, in which exposure influences mortality and disease incidence rates. Because many risk factors are related to a variety of chronic diseases, these Markov models potentially contain a large number of states (risk factor and disease combinations), providing a challenge both technically (keeping down execution time and memory use) and practically (estimating the model parameters and retaining transparency). To meet this challenge, we propose an approach that combines micro-simulation of the exposure information with macro-simulation of the diseases and survival. This approach allows users to simulate exposure in detail while avoiding the need for large simulated populations because of the relative rareness of chronic disease events. Further efficiency is gained by splitting the disease state space into smaller spaces, each of which contains a cluster of diseases that is independent of the other clusters. The challenge of feasible input data requirements is met by including parameter calculation routines, which use marginal population data to estimate the transitions between states. As an illustration, we present the recently developed model DYNAMO-HIA (DYNAMIC MODEL for Health Impact Assessment) that implements this approach.

  17. Risk assessment for carnitine.

    Science.gov (United States)

    Hathcock, John N; Shao, Andrew

    2006-10-01

    Carnitine is a conditionally essential amino acid-like compound involved in the transport of long-chain fatty acids into the mitochondria during the beta-oxidation process. Carnitine has become an increasingly popular ingredient in dietary supplements, especially weight loss and some sports nutrition products. A number of clinical trials have been conducted examining the effect of carnitine supplementation on weight loss and energy balance. Regarding safety, systematic evaluation of the research designs and data do not provide a basis for risk assessment and the usual safe upper level of intake (UL) derived from it unless the newer methods described as the observed safe level (OSL) or highest observed intake (HOI) are utilized. The OSL risk assessment method indicates that the evidence of safety is strong at intakes up to 2000mg/day l-carnitine equivalents for chronic supplementation, and this level is identified as the OSL. Although much higher levels have been tested without adverse effects and may be safe, the data for intakes above 2000mg/day are not sufficient for a confident conclusion of long-term safety.

  18. Quantitative assessment of possible human health risk associated with consumption of arsenic contaminated groundwater and wheat grains from Ropar Wetand and its environs.

    Science.gov (United States)

    Sharma, Sakshi; Kaur, Jagdeep; Nagpal, Avinash Kaur; Kaur, Inderpreet

    2016-09-01

    Arsenic (As) is a carcinogenic metalloid that enters food chain through food and water and poses health risk to living beings. It is important to assess the As status in the environment and risks associated with it. Hence, a risk assessment study was conducted across Ropar wetland, Punjab, India and its environs in pre-monsoon season of 2013, to estimate the risk posed to adults and children via daily consumption of As contaminated groundwater and wheat grains. Arsenic concentrations determined in groundwater, soil and wheat grain samples using atomic absorption spectrometer ranged from 2.90 to 10.56 μg L(-1), 0.06 to 0.12 mg kg(-1) and 0.03 to 0.21 mg kg(-1), respectively. Arsenic in wheat gra