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Sample records for articular inflamatoria del

  1. Enfermedad inflamatoria intestinal : papel del análisis molecular de los virus de la familia herpes sobre material tisular

    OpenAIRE

    Azueta Etxebarria, Ainara

    2014-01-01

    RESUMEN: Los virus de la familia del herpes humano afectan al hombre de manera ubicua lo que hace discutible su papel patogenético en ciertas enfermedades a pesar de demostrarse su presencia. Por otro lado, la dificultad para interpretar las técnicas de laboratorio disponibles para su detección y llegar a un diagnóstico preciso impide en la mayor parte de los casos la detección precoz de la infección y el tratamiento eficaz. Existen casos de enfermedad inflamatoria intestinal en los que...

  2. Pharmacological Nutrition in Inflammatory Bowel Diseases Nutrición farmacológica en las enfermedades inflamatorias del instestino

    Directory of Open Access Journals (Sweden)

    F. G. Campos

    2003-04-01

    Full Text Available Inflammatory Bowel Diseases - ulcerative colitis and Crohn’s disease- are chronic gastrointestinal inflammatory diseases of unknown etiology. Decreased oral intake, malabsorption, accelerated nutrient losses, increased requirements, and drug-nutrient interactions cause nutritional and functional deficiencies that require proper correction by nutritional therapy. The goals of the different forms of nutritional therapy are to correct nutritional disturbances and to modulate inflammatory response, thus influencing disease activity. Nutritional intervention may improve outcome in certain individuals; however, because of the costs and complications of such therapy, careful selection is warranted. Total parenteral nutrition has been used to correct and prevent nutritional disturbances and to promote bowel rest during active disease, mainly in cases of digestive fistulae with a high output. Its use should be reserved for patients who cannot tolerate enteral nutrition. Enteral nutrition is effective in inducing clinical remission of disease in adults and promoting growth in children. Recent research has focused on the use of specific nutrients as primary treatment agents. Although some reports have indicated that glutamine, short-chain fatty acids, antioxidants and immunonutrition with omega-3 fatty acids are an important therapeutic alternative in the management of inflammatory bowel diseases, the beneficial reported effects have yet to be translated into the clinical practice. The real efficacy of these nutrients still need further evaluation through prospective and randomized trials.Las enfermedades inflamatorias del intestino -colitis ulcerosa y enfermedad de Crohn- son enfermedades crónicas de causa desconocida. La disminución de la ingesta, la malabsorción, la pérdida acelerada de nutrientes, el aumento de los requerimientos y las interacciones entre medicamentos y nutrientes determinan carencias nutricionales y funcionales que obligan a una

  3. Rescate articular con colgajo anterolateral del muslo

    OpenAIRE

    F.J. García-Bernal; P. Zayas-Pinedo; J. Regalado-Bilbao; C. Jul-Vázquez; R. Fuentes-Gastañaga

    2015-01-01

    La preservación del nivel de amputación tanto de la extremidad superior como de la inferior, puede mejorar la función residual y el proceso de rehabilitación protésica de la misma. Ambas van a estar condicionadas por la longitud restante de la extremidad, la presencia o no de articulaciones operativas y la calidad de la cobertura del muñón. Presentamos 2 casos de amputaciones. El primero es un caso agudo de amputación traumática de extremidad superior a la altura del tercio proximal de antebr...

  4. Rescate articular con colgajo anterolateral del muslo

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    F.J. García-Bernal

    2015-06-01

    Full Text Available La preservación del nivel de amputación tanto de la extremidad superior como de la inferior, puede mejorar la función residual y el proceso de rehabilitación protésica de la misma. Ambas van a estar condicionadas por la longitud restante de la extremidad, la presencia o no de articulaciones operativas y la calidad de la cobertura del muñón. Presentamos 2 casos de amputaciones. El primero es un caso agudo de amputación traumática de extremidad superior a la altura del tercio proximal de antebrazo, que asocia avulsión cutánea circular desde el tercio medio del brazo y con articulación de codo conservada. El segundo, es la secuela de una amputación infracondílea de extremidad inferior por osteosarcoma que presenta fístulas cutáneas con drenaje supurativo por osteomielitis en el muñón tibial. En ambos pacientes realizamos cobertura con colgajo anterolateral de muslo anastomosado a la arteria radial en el caso de la extremidad superior, y a la arteria genicular descendente en la extremidad inferior. En los dos casos el postoperatorio transcurrió sin complicaciones, logrando preservar las articulaciones del codo y de la rodilla respectivamente, así como la posterior rehabilitación protésica. Consideramos que el colgajo anterolateral del muslo permite aportar tejido de buena calidad como cobertura del muñón de amputación. Dadas las características del tejido aportado y su volumen, es idóneo tanto para cobertura de defectos agudos como de déficits de almohadillado en casos crónicos.

  5. Valor del estudio celular del esputo en el seguimiento de las enfermedades inflamatorias de la vía aérea

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    Juan Antonio Mazzei

    2012-08-01

    Full Text Available El análisis celular del esputo, espontáneo u obtenido mediante la técnica de esputo inducido, se ha transformado en una herramienta ampliamente difundida para la evaluación y orientación del tratamiento de las enfermedades inflamatorias de la vía aérea, principalmente asma, enfermedad pulmonar obstructiva crónica y bronquitis eosinofílica. Se han aportado evidencias sobre la utilidad de la técnica del esputo inducido, validada y estandarizada, para ser empleada en pacientes con dificultades para expectorar. Numerosas investigaciones dieron cuenta de la efectividad de basar las decisiones terapéuticas en el componente inflamatorio de la vía aérea mediante el recuento de células en el esputo. Varios estudios mostraron que, en pacientes con asma el análisis celular de esputo guía en la determinación de estrategias para disminuir las exacerbaciones y para mejorar la función pulmonar, aun en pacientes con asma grave, para disminuir el remodelamiento; también se ha descrito su utilidad en pacientes con EPOC, para la disminución de las exacerbaciones.

  6. Caracterización hemodinámica doppler e inflamatoria de las preeclámpticas: análisis del efecto del tratamiento con parches de nitroglicerina

    OpenAIRE

    Reyna Villasmil,Eduardo

    2012-01-01

    De esta investigación prospectiva de la caracterización hemodinámica Doppler e inflamatoria de pacientes con preeclampsia y de un grupo control de embarazadas normotensas sanas, así como el análisis del efecto del tratamiento con parches de nitroglicerina en las preeclámpticas, se concluye que: Las preeclámpticas tiene valores significativamente más latos de velocimetría Doppler en las arterias uterinas, umbilical, renal fetal y hepática fetal y más bajos de la arteria cerebral media fetal co...

  7. Tratamiento de los defectos del cartílago articular en la rodilla

    OpenAIRE

    Reverté Vinaixa, María Mercedes

    2015-01-01

    Las lesiones condrales y osteocondrales en la rodilla aparecen en gente joven, activa y con gran expectativa de vida. Estás suponen un gran problema, puesto que este una vez destruido, ya no se repara. Debido a la escasa capacidad intrínseca de curación del cartílago, sus lesiones tienden a causar morbilidad en forma de dolor articular y disfunción. Existen diferentes técnicas quirúrgicas que mejoran la sintomatología y la historia natural de las lesiones condrales. Las lesiones del cartílago...

  8. Hiperplasia Fibrosa Inflamatoria: reporte de un caso

    OpenAIRE

    Casian Romero,A; Trejo Quiroz,P; De León Torres,C; D Carmona Ruiz

    2011-01-01

    Introducción: La Hiperplasia Fibrosa Inflamatoria es una alteración caracterizada por un agrandamiento del tejido conectivo; se considera una lesión reactiva ya que se presenta como respuesta a una irritante crónico local; es una lesión común en pacientes adolescentes y de edad adulta debido a que su etiología principal se asocia a maloclusión, al uso de aparatología protésica u ortodóntica mal ajustada, así como a la presencia de biofilm. Sin embargo, la población infantil, principalmente en...

  9. MODELADO MATEMÁTICO DEL COMPORTAMIENTO MECÁNICO DE UN FRAGMENTO DE CARTÍLAGO ARTICULAR

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    NANCY STELLA LANDÍNEZ

    2009-01-01

    Full Text Available El cartílago articular es un material biológico poroelástico que permite la distribución de las cargas mecánicas y el movimiento de las articulaciones. Como material bifásico, en presencia de carga, el cartílago articular deforma su matriz sólida y modifica la presión hidrostática del fluido en su interior. El objetivo del presente trabajo es implementar numéricamente un modelo matemático que predice el comportamiento mecánico del cartílago articular teniendo en cuenta la dualidad entre la matriz sólida y el líquido articular, y la característica de poroelasticidad. Utilizando una metodología basada en el método de los elementos finitos, se simuló el comportamiento de un fragmento de cartílago articular en una y dos dimensiones, ante cargas mecánicas de tensión, compresión y oscilación. El análisis de los resultados permite validar cualitativamente el comportamiento poroelástico del modelo debido a la deformación de la matriz sólida y a la salida de fluido que modifica la presión del mismo de manera similar a lo reportado en trabajos experimentales. Se concluye que el modelo matemático permite realizar predicciones sobre el comportamiento biomecánico del cartílago articular, contribuyendo al proceso investigativo en áreas como la biomecánica y la ingeniería de tejidos.

  10. Valor del estudio celular del esputo en el seguimiento de las enfermedades inflamatorias de la vía aérea Value of sputum analysis in the management of inflammatory airway diseases

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    Juan Antonio Mazzei

    2012-08-01

    Full Text Available El análisis celular del esputo, espontáneo u obtenido mediante la técnica de esputo inducido, se ha transformado en una herramienta ampliamente difundida para la evaluación y orientación del tratamiento de las enfermedades inflamatorias de la vía aérea, principalmente asma, enfermedad pulmonar obstructiva crónica y bronquitis eosinofílica. Se han aportado evidencias sobre la utilidad de la técnica del esputo inducido, validada y estandarizada, para ser empleada en pacientes con dificultades para expectorar. Numerosas investigaciones dieron cuenta de la efectividad de basar las decisiones terapéuticas en el componente inflamatorio de la vía aérea mediante el recuento de células en el esputo. Varios estudios mostraron que, en pacientes con asma el análisis celular de esputo guía en la determinación de estrategias para disminuir las exacerbaciones y para mejorar la función pulmonar, aun en pacientes con asma grave, para disminuir el remodelamiento; también se ha descrito su utilidad en pacientes con EPOC, para la disminución de las exacerbaciones.Cellular analysis of sputum either spontaneous or by induced sputum technique, has become a widespread tool for the evaluation and guidance of treatment of inflammatory diseases of the airway, primarily asthma, COPD and eosinophilic bronchitis. Induced sputum method is a validated, standardized and non-invasive technique, useful in patients with difficulties to expectorate. Its implementation is simple and cost effective. Numerous investigations have shown the effectiveness of basing treatment decisions on the inflammatory component of the airway by counting cells in sputum. Several studies have demonstrated that in patients with asthma, results of this analysis can guide in defining strategies to reduce exacerbations and to improve lung function even in patients with severe asthma, as well as to decrease the remodeling; in addition, a reduction in exacerbations in COPD patients

  11. Hiperplasia fibrosa inflamatoria y posibles factores asociados en adultos mayores

    OpenAIRE

    Rodríguez Zegarra, Anita F.; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Sacsaquispe-Contreras, Sonia; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    El propósito del estudio fue determinar la prevalencia de hiperplasia fibrosa inflamatoria (HFI)asociada al uso de prótesis dental removible y sus factores asociados como: sexo, grado deinstrucción, edad, compromiso sistémico, estado nutricional e higiene oral del sujeto; tipo ytiempo de uso de la prótesis, tamaño y ubicación de la lesión en adultos mayores residentes delAlbergue Central “Ignacia Rodulfo Vda. de Canevaro”. Se evaluaron 91 sujetos mayores de 60años (80,67+7,65), que portaban p...

  12. Cambios osteoartrósicos condíleos relacionados al espesor de la superficie articular del temporal y espacio articular temporomandibular según tomografía computarizada Cone Beam

    OpenAIRE

    2014-01-01

    Objetivo. Determinar los cambios osteoartrósicos condíleos (COC) relacionados al espesor de la superficie articular del temporal (ESAT) y al espesor del espacio articular temporomandibular (EATM) en tomografía computarizada Cone Beam, según sus signos radiográficos, edad, sexo y localización. Materiales y métodos. Se analizaron 77 casos de un centro de diagnóstico por imágenes. Se evaluaron las articulaciones temporomandibulares (ATM) derecha e izquierda de forma independiente. Todos...

  13. Anemia y enfermedad inflamatoria intestinal Anemia and inflammatory bowel disease

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    F. de la Morena

    2008-05-01

    Full Text Available La anemia es una de las complicaciones más comunes de la enfermedad inflamatoria intestinal. La alta frecuencia de valores bajos de hemoglobina en estos enfermos provoca en muchas ocasiones una infravaloración por parte del médico de esta circunstancia, lo que se traduce en la falta de un tratamiento eficaz. Por otro lado, el carácter complejo de los mecanismos de producción de la anemia en la enfermedad inflamatoria intestinal con frecuencia plantea dudas acerca del tratamiento más adecuado. La identificación correcta de los pacientes con anemia así como la instauración del tratamiento más idóneo serán los dos pilares fundamentales para la mejoría de la calidad de vida de los enfermos. El uso correcto de los suplementos de hierro y las nuevas formulaciones de hierro parenteral, con o sin eritropoyetina asociada, han revolucionado nuestro abordaje de esta complicación evolutiva de la enfermedad inflamatoria intestinalAnemia is a most common complication of inflammatory bowel disease. A high frequency of low hemoglobin values in these patients often leads physicians to subestimate this condition, which translates into ineffective treatment. On the other hand, the complex nature of anemia-inducing mechanisms in inflammatory bowel disease frequently raises doubt about the most appropriate therapy. A correct identification of patients with anemia, and adequate therapy are the essential pillars for improved quality of life. The right use of iron supplementation, and novel parenteral iron formulations, either with or without associated erythropoietin, have revolutionized our approach of this complication in the course of inflammatory bowel disease

  14. Tratamiento kinésico de la ruptura total del tendón del músculo supraespinoso con y sin intervención quirúrgica

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    Aldana, Emauel

    2015-01-01

    La ruptura total del tendón del músculo del supraespinoso es una lesión que ocurre por la existencia anterior de un proceso de naturaleza traumática, inflamatoria o degenerativa, quedando una zona vulnerable y dolorosa, presentando limitaciones articulares y debilidad muscular. Esta patología afecta con mayor frecuencia a personas de edades avanzadas. Objetivo general: Evaluar la evolución de los pacientes que sufrieron rupturas totales tendinosas del músculo supraespinoso con ...

  15. Luxaciones discales y los problemas por interferencia del disco articular en la articulación temporomandibular

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    Martínez Verdú, Jesús; Martínez Gil, José LUis; Fuster Antón, Iván

    2007-01-01

    Introducción y objetivos: Los trastornos temporomandibulares incluyen un conjunto de patologías de origen multifactorial, que tienen en común la posibilidad de alterar funcionalmente el aparato masticatorio. Los objetivos planteados se basan en realizar un estudio de las diferentes patologías de la mandíbula provocadas por la interferencia del disco articular. Material y método: Se han utilizado bases de datos como Medlina, Science Direct, Bvs. Catalogos electrónicos como O.P.A...

  16. Rol de galectina-1 en la fisiopatología de las Enfermedades Inflamatorias Intestinales

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    Papa Gobbi, Rodrigo

    2015-01-01

    Las Enfermedades Inflamatorias Intestinales (EII) son un conjunto de patologías crónicas multifactoriales en las cuales se produce una respuesta inmune aberrante contra componentes de la microbiota intestinal. Dentro de las EII, la colitis ulcerosa (CU) y la enfermedad de Crohn (EC) son las dos formas más estudiadas. Si bien existen diferencias en la presentación clínica de estas patologías, en ambos casos los linfocitos T (LT) de la mucosa sobre-expresan citoquinas pro-inflamatorias del perf...

  17. Capacidad condrogénica de injertos libres de periostio en la reparación de defectos del cartílago articular: estudio experimental en conejos

    OpenAIRE

    1996-01-01

    Ante la incapacidad de reparación de las lesiones del cartílago articular, hemos diseñado un modelo experimental, consistente en la realización de una úlcera condral de 8 mm, en la superficie articular de la rótula, en 48 conejos distribuidos en 2 series. Mientras en la serie control (24 conejos) dicha úlcera se dejó a evolución espontánea, en la experimental (24 conejos) fue cubierta con plastia libre de periostio tibial para poder investigar la posibilidad de regeneración del...

  18. Response of first attack of inflammatory bowel disease requiring hospital admission to steroid therapy Respuesta al tratamiento esteroideo del primer brote de enfermedad inflamatoria intestinal que requiere ingreso hospitalario

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    M. Abu-Suboh Abadía

    2004-08-01

    buena en caso de remisión completa o mala si la remisión es parcial o ausente. Se realizó estudio univariado y multivariado según estadística no paramétrica de diferentes variables sociodemográficas y biológicas. Resultados: se han incluido 45 pacientes con EC y 41 con CU. La tasa de buena respuesta fue del 64,4% en la EC y del 60,9% en la CU. El análisis univariado demostró que los pacientes con buena respuesta tienen un tiempo de evolución más corto y un menor número de brotes previos (p < 0,05 para la EC. Sin embargo, el análisis multivariado no demostró que alguna variable de las analizadas tuviera valor predictivo. Conclusión: la respuesta de los brotes graves de enfermedad inflamatoria intestinal a los corticoides es alrededor del 60% en la EC y CU. Los datos del presente estudio no permiten predecir qué pacientes son los que responderán al tratamiento.

  19. Efecto del uso de exoprótesis sobre la distribución de esfuerzos del cartílago articular de la cadera

    OpenAIRE

    2015-01-01

    Resumen: Se desarrolla un modelo numérico para la comparación del estado de esfuerzos en la articulación coxofemoral en amputados transfemorales. Su enfoque está en comparar la pierna sana y la amputada durante la fase de bipedestación. Para la ejecución, se reconstruyen las geometrías de los huesos involucrados a partir de tomografía axial, mientras que los cartílagos fueron creados con base en las respectivas superficies articulares. Con base en la literatura se definen las propiedades m...

  20. Citocinas anti-inflamatorias y sus acciones y efectos en la sepsis y el choque séptico - Anti-inflammatory cytokines and their actions and effects in the sepsis and septic shock

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    González Álvarez, Ricardo; Zamora Rodríguez, Zullit; Alonso González, Yaima

    2009-01-01

    ResumenLas citocinas anti- inflamatorias reconocidas son las interleucinas (IL) IL-4, IL-10, IL-6, IL-13, el factor estimulante de colonia granulocito –macrófago (FEC-GM) y el interferón alfa (IFN-alfa), los cuales tienen la capacidad de inhibir la liberación de las citocinas pro-inflamatorias y de inducir la producción del antagonista del receptor de la IL-1 y la liberación del receptor soluble del FNT, los cuales limitan algunas de las actividades de las citocinas pro-inflamatorias IL-1 y F...

  1. Valoración de la eficacia terapeútica del lavado articular en el tratamiento sintomático de pacientes con artrosis de rodilla

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    Frías Tejederas, Gabriel

    2011-01-01

    En el tratamiento de la osteoartrosis de orilla (OA) se están ensayando diferentes modalidades terapéuticas, siendo el lavado articular, técnica consistente en hacer pasar suero fisiológico, frío a través de la articulación de la rodilla, un procedimiento ampliamente aceptado para el tratamiento de esta patología. OBJETIVOS Valorar la eficacia del lavado articular en el tratamiento sintomático de pacientes con artrosis de rodilla. PACIENTES Y MÉTODOS Estudio prospectivo de 145 pacientes delos...

  2. Efectividad de la laserterapia en el tratamiento del dolor articular temporomandibular en pacientes atendidos en Amancio, 2012-2013

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    Carmen de los Milagros García Alguacil

    2014-08-01

    Full Text Available La alta prevalencia de pacientes que acuden con trastornos temporomandibulares aquejados de dolor resultó ser la motivación para realizar este estudio descriptivo, en la clínica estomatológica del policlínico “Luis Aldana Palomino”, en el periodo comprendido de enero de 2012 a enero de 2013, con el propósito de determinar la efectividad de la laserterapia en el tratamiento del dolor articular temporomandibular. La muestra quedó conformada por 75 pacientes, atendidos en el servicio de prótesis de dicha institución. Se analizó la edad, sexo y efecto analgésico, el número de sesiones recibidas con esta terapia, así como la duración del efecto. Predominó el dolor en el grupo de 40 – 59 años y el sexo femenino fue el más afectado. A partir de la tercera sesión se comenzaron a remitir los síntomas en la mitad de los pacientes y en la mayoría el efecto analgésico se mantuvo por más de tres meses después de concluido el tratamiento. No se encontraron efectos adversos durante el tratamiento con el láser

  3. Polirradiculopatía inflamatoria crónica sensitiva

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    Paz Zuberbuhler

    2013-06-01

    Full Text Available La polirradiculopatía inflamatoria crónica sensitiva es una entidad definida, frecuentemente subdiagnosticada y potencialmente tratable. Debe ser sospechada en pacientes con ataxia sensitiva, estudios de conducción nerviosa normales y una resonancia magnética que muestre engrosamiento y realce con gadolinio de las raíces lumbosacras. Presentamos el caso de un hombre de 57 años de edad con marcada ataxia sensitiva en pierna izquierda. Al examen físico presentaba fuerza conservada, reflejos osteotendinosos disminuidos, tacto fino y superficial reducidos por debajo de las rodillas; abatiestesia y apalestesia en ambos pies. Los estudios de conducción nerviosa eran normales, los potenciales evocados somatosensitivos tibiales con ausencia de respuesta bilateral. El líquido cefalorraquídeo presentaba hiperproteinorraquia sin células. La resonancia magnética mostró engrosamiento y realce con gadolinio de las raíces lumbosacras. El paciente fue tratado con inmunoglobulina endovenosa (IgEV a 2 g/kg durante 5 días, con buena respuesta. La evolución clínica, la hiperproteinorraquia, el realce de raíces en la resonancia magnética, la buena respuesta a la inmunoterapia y la exclusión de otras causas de ataxia sensitiva fueron compatibles con el diagnóstico de polirradiculopatía inflamatoria crónica sensitiva. Para el diagnóstico de esta enfermedad se requiere la identificación del compromiso aislado de las raíces sensitivas.

  4. Osteoporosis y enfermedad inflamatoria intestinal Osteoporosis and inflammatory bowel disease

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    L. Menchén

    2005-02-01

    Full Text Available La enfermedad inflamatoria intestinal es una entidad crónica de etiología desconocida en cuyo desarrollo influyen múltiples variables, como son la susceptibilidad individual, genética e inmunológica, así como diferentes factores ambientales. Sus manifestaciones clínicas son muy variadas y pueden afectar a otros órganos diferentes del tracto digestivo, convirtiéndose por tanto en una enfermedad multisistémica. En los últimos años existe un interés creciente por una de estas manifestaciones, la osteoporosis y la osteopenia, que puede afectar hasta al 42% de los pacientes y condiciona un importante aumento de la morbilidad. La inactividad, el tratamiento corticoideo prolongado, las deficiencias nutricionales y la propia enfermedad pueden favorecer el desarrollo de esta complicación. En esta revisión se repasan aspectos clínicos y etiológicos de la osteoporosis asociada a la enfermedad inflamatoria intestinal y se ofrecen pautas para su diagnóstico y tratamiento.Inflammatory bowel disease is a chronic disease with an unknown ethiology although multiple factors intervene such as individual, genetic and immunologic susceptibility, as well as different environmental factors. Like other multisystemic diseases, its clinical manifestations are diverse and it may affect other organs besides the gastrointestinal tract. In the last few years there is a growing interest for one of these extraintestinal manifestations, osteoporosis and osteopenia that may affect up to 42% of patients and can condition an important increase in morbility. Inactivity, prolonged corticosteroid treatment, nutritional deficiencies and the disease per se have an important role in the development of this complication. This article reviews clinical and ethiological aspects of inflammatory bowel disease associated osteoporosis and offers a strategy for diagnosis and treatment.

  5. Análisis a largo plazo del cartílago producido por injertos libres de periostio tibial en lesiones articulares del cóndilo femoral del conejo

    OpenAIRE

    1999-01-01

    Propósito de estudio: Analizar la reparación de lesiones del cartílago articular con injertos libres de periostio. Material y Métodos: 36 conejos de Nueva Zelanda, de 4 a 6 semanas. Creación de úlcera condral en cóndilo femoral interno. Evolución espontánea en 18 animales. Tratamiento con injerto libre de periostio tibial fijado con Tissucol R en otros 18 animales. Sacrificio en grupos de 67 animales a las 8, 12 y 24 semanas. Valoración de resultados macroscópicos, histológicos e histoquímico...

  6. Nutrición y enfermedad inflamatoria intestinal Nutrition and inflammatory bowel disease

    OpenAIRE

    2007-01-01

    En este artículo se revisan las causas y consecuencias de los déficits nutricionales en la enfermedad inflamatoria intestinal, con especial énfasis en sus implicaciones fisiopatológicas. Además, se sientan las bases de la intervención nutricional en estos pacientes tanto desde la perspectiva del consejo dietético como del uso de soporte nutricional especializado. Se hace un especial hincapié en la discusión de las evidencias existentes en favor de un papel terapéutico primario de la nutrición...

  7. Caracterización de las células mesenquimales del paquete adiposo de Hoffa en pacientes con diferente grado de afectación articular

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    Argüello Cuenca, José Manuel

    2016-01-01

    Desde la antigüedad es conocida la problemática que ocasionan las lesiones condrales y su dificultad de tratamiento por el escaso poder reparativo que presenta el cartílago. Hoy día son muchas las técnicas, algunas de ellas de complejidad y coste muy elevados, que tratan de dar solución a esta situación, dando idea de la magnitud del problema al que nos enfrentamos. El gran caballo de batalla al que nos enfrentamos en la lucha contra la degeneración articular o artrosis, no es otro que tratar...

  8. Reparación de lesiones del cartílago articular de la rótula de conejos con injertos libres de pericondrio costal y periostio tibial: Estudio histológico comparativo

    OpenAIRE

    1998-01-01

    El propósito del presente, estudio experimental es comparar la capacidad condrogénica de injertos libres de pericondrio y periostio en lesiones que afectan a todo el espesor del cartílago articular rotuliano. Para ellos, se eligieron 18 conejos adolescentes de Nueva Zelanda con un peso comprendido entre los 2400 y 3600 gramos, a los que se realizó una lesión de 6 mm de diámetro y 3 mm de espesor en la superficie articular de la rótula, y se distribuyeron de modo aleatorio en tres grupos: con...

  9. Tratamiento del paciente con artrosis

    Directory of Open Access Journals (Sweden)

    Francisco Vargas Negrín

    2014-01-01

    Full Text Available El manejo terapéutico del paciente con artrosis tiene como objetivo disminuir la sintomatología dolorosa e inflamatoria, mejorar la capacidad funcional del paciente y la aplicación de intervenciones terapéuticas eficaces y lo más seguras posibles. Un enfoque centrado en el paciente implica su participación activa en el diseño del plan terapéutico y en la toma de decisiones informadas oportunas en todas las etapas de la enfermedad. La educación terapéutica, la actividad física y el ejercicio terapéutico junto con el control de peso, en caso de sobrepeso u obesidad, constituyen el núcleo central del tratamiento. Los autocuidados individuales y por los familiares son fundamentales en el control del día a día del paciente. El uso de terapias físicas, ayudas técnicas (bastón, etc. y de fármacos tipo analgésicos simples, opioides y antiinflamatorios tiene evidencias demostradas en el control del dolor, mejora la funcionalidad y la calidad de vida del paciente y una clara recomendación de uso en el tratamiento de la artrosis. La cirugía conservadora y la de reemplazo articular se indican en los casos en los que no se logran los objetivos terapéuticos en casos concretos.

  10. Variables psicológicas y calidad de vida en la enfermedad inflamatoria intestinal

    OpenAIRE

    Iglesias Rey, Marta

    2013-01-01

    Antecedentes: Bajo la denominación de enfermedad inflamatoria intestinal se incluyen un grupo de enfermedades crónicas del tracto gastrointestinal entre las que destacan por su gravedad y prevalencia, la enfermedad de Crohn y la colitis ulcerosa. El curso clínico se caracteriza por la aparición de brotes de reagudización de diversa gravedad y periodos de remisión en los que el paciente se encuentra clínicamente estable. El comienzo en edades tempranas, la cronicidad, necesidad de cirugía y ho...

  11. Hipnosis clínica en un caso de enfermedad inflamatoria intestinal

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    J. C. FERNÁNDEZ MÉNDEZ

    2000-01-01

    Full Text Available Un sujeto de veinte años con una enfermedad inflamatoria intestinal fue tratado con hipnosis. Hasta donde sabemos es el primer informe que documenta el empleo de la hipnosis clínica en un paciente con enfermedad de Crohn, para reducir el estrés y afrontar las demandas originadas por la patología digestiva. Además, otro aspecto importante en el presente trabajo, es el registro exhaustivo y consecutivo de la sintomatología gastrointestinal, un punto débil en la gran mayoría de los trabajos precedentes. Al finalizar la intervención psicológica disminuyó notablemente el nivel de intensidad del estrés, el número de deposiciones diarias así como la intensidad del dolor abdominal. Estos resultados se mantuvieron a lo largo del seguimiento.

  12. FACTORES BIOQUÍMICOS Y CELULARES EN LA RESPUESTA INFLAMATORIA PULPAR EN LOS EQUINOS Y SU IMPORTANCIA EN LA FARMACOTERAPIA ACTUAL PARA LA ABOLICIÓN DEL DOLOR PRE, INTRA Y POSOPERATORIO ENDODÓNTICO

    OpenAIRE

    Rafael Argueta López; Rafael Argueta García; Ana María Berlín Gómez

    2013-01-01

    La enfermedad pulpar dental es un de sorden bucal común de los caballos y de gran impacto en la práctica de la clínica del dolor y anestesiología estomatológica veterinaria en equinos. Desafortunadamente, el examen oral realizado por la mayor parte de los médico veterinarios especialistas en equinos consiste sólo en separar los labios, observar los incisivos y colocar un dedo en el carrillo para palpar puntas sobre los primeros dientes superiores del carrillo. Este tipo de examen dete cta sól...

  13. Neuritis óptica inflamatoria Inflammatory optic neuritis

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    T. Ayuso

    2009-08-01

    Full Text Available La neuritis óptica inflamatoria (NO es la causa más frecuente de pérdida visual aguda en adultos jóvenes. Aunque el pronóstico visual es excelente en la mayoría de los casos, muchos pacientes desarrollarán otra patología como esclerosis múltiple en la evolución posterior. La historia natural de la NO ha sido estudiada en múltiples trabajos en los últimos años; uno de los más importantes es el Optic Neuritis Treatment Trial. La Resonancia Magnética tiene un papel fundamental en el diagnóstico etiológico de la NO y en la predicción del riesgo de conversión a esclerosis múltiple. Recientemente se han incorporado nuevas técnicas exploratorias como la tomografia de coherencia óptica, útil para el diagnóstico y pronóstico; se han identificado biomarcadores séricos que ayudan en el diagnóstico de otras patologías de naturaleza autoinmune que producen NO. Un mejor conocimiento de los datos clínicos y exploratorios de la NO típica permitirá un estudio diagnóstico más rápido y certero. El tratamiento de la NO con esteroides debe ser individualizado teniendo en cuenta que no modifican el pronóstico a largo plazo y en pacientes con alto riesgo de conversión a esclerosis múltiple debe plantearse terapia inmunomoduladora. Este trabajo revisa los datos existentes en la literatura referentes a las manifestaciones clínicas, el diagnóstico etiológico y diferencial y tratamiento de la NO inflamatoria.Inflammatory Optic Neuritis (ON is the most frequent cause of acute visual loss in young adults. Although the visual prognosis is excellent in the majority of cases, many patients develop pathology, such as multiple sclerosis, in its subsequent evolution. The natural history of ON has been studied in numerous works in recent years; one of the most important of which is Optic Neuritis Treatment Trial. Magnetic Resonance plays a fundamental role in the etiological diagnosis of ON and in predicting the risk of conversion into

  14. Traducción, adaptación y validación al español del cuestionario de calidad de vida de 32 ítems (IBDQ-32 de la enfermedad inflamatoria intestinal Spanish translation, adaptation, and validation of the 32-item questionnaire on quality of life for inflammatory bowel disease (IBDQ-32

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    M. Masachs

    2007-09-01

    Full Text Available Introducción: la medida de la calidad de vida relacionada con la salud (CVRS tiene una reconocida importancia en la evaluación, el manejo y el seguimiento de la enfermedad inflamatoria intestinal. El instrumento de medida más utilizado es la versión de 32 ítems del Inflammatory Bowel Disease Questionnaire (IBDQ-32, que no está adaptado al español. Objetivo: traducir la versión del IBDQ-32 al español y determinar su validez, fiabilidad y sensibilidad tanto en la colitis ulcerosa como en la enfermedad de Crohn. Método: estudio prospectivo en dos fases: traducción y posterior validación del IBDQ-32 al español. La traducción se ha basado en la versión al español validada del IBDQ-36, y los ítems del IBDQ-32 no incluidos en el IBDQ-36 se tradujeron "de novo". Una vez terminada la traducción del IBDQ32, se aplicó un cuestionario específico de comprensión. Para determinar las propiedades psicométricas del IBDQ-32, un grupo de pacientes completó el IBDQ-36 ya validado al español y el IBDQ-32. Resultados: se han incluido 84 pacientes (53 con enfermedad de Crohn y 31 con colitis ulcerosa. La mediana de la puntuación global de ambos cuestionarios en los 84 pacientes no fue diferente (6,1 vs. 6,2, p = ns y su correlación de Spearman fue muy significativa (r = 0,97, p Introduction: the measurement of health-related quality of life (HRQoL has an established relevance in the assessment, management, and follow-up of inflammatory bowel disease. The most commonly used measuring instrument is the 32-item version of Inflammatory Bowel Disease Questionnaire (IBDQ-32, which has never been adapted to Spanish. Objective: to translate IBDQ-32 into Spanish, and to establish its validity, reliability, and sensitivity both in ulcerative colitis and Crohn's disease. Method: a prospective study in two phases -translation into Spanish and subsequent validation of IBDQ-32. Translation was based on the validated Spanish version of IBDQ-36, and IBDQ-32

  15. Amiloidosis secundaria en la enfermedad inflamatoria intestinal Secondary amyloidosis in Chrohn's disease

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    S. Seijo Ríos

    2008-12-01

    Full Text Available La amiloidosis es una entidad clínica que se produce a consecuencia del depósito a nivel extracelular de un material proteico amorfo, causando una desorganización de la arquitectura normal de múltiples órganos y tejidos y, por tanto, una alteración funcional de los mismos. La amiloidosis secundaria es una complicación infrecuente pero muy grave que aparece en el contexto de neoplasias, enfermedades infecciosas e inflamatorias de curso crónico, como es el caso de la enfermedad inflamatoria intestinal, principalmente enfermedad de Crohn, ensombreciendo el pronóstico de estos pacientes. A continuación presentamos dos casos clínicos correspondientes a dos pacientes con enfermedad de Crohn que desarrollaron amiloidosis secundaria.Amyloidosis is a clinical entity that results from the deposition of an extracellular protein material that causes disruption in the normal architecture of multiple organs and tissues, and impairs their function. Secondary amyloidosis is a rare but serious complication that may worsen the prognosis of patients with cancer, infection or chronic inflammatory disease, including inflammatory bowel disease, particularly Crohn's disease. We report two cases of Crohn's disease associated with secondary amyloidosis.

  16. Manifestaciones reumatológicas de la enfermedad inflamatoria intestinal Rheumatologic manifestations of inflammatory bowel disease

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    Octavio Germán Muñoz Maya

    2006-01-01

    Full Text Available La enfermedad inflamatoria intestinal (EII se caracteriza por la activación inapropiada del sistema inmune de la mucosa intestinal y sus dos formas de presentación son: la colitis ulcerativa y la enfermedad de Crohn. Las manifestaciones extraintestinales se presentan hasta en el 36% de los pacientes y pueden comprometer cualquier órgano o sistema. La disfunción inmune se caracteriza por el desequilibrio entre los mediadores proinflamatorios y los antinflamatorios y se expresa como una enfermedad sistémica. Las manifestaciones reumatológicas asociadas a la EII son de tres tipos: la artritis periférica, la espondiloartropatía y una tercera categoría que incluye lesiones dérmicas, oftálmicas y del metabolismo óseo, entre otras. El manejo de estas manifestaciones se basa en la terapia sistémica para el control de la actividad inflamatoria local utilizando esteroides, derivados de la 5-ASA, inmunomoduladores y, en los últimos años, terapia anti-TNF. The main feature of inflammatory bowel disease (IBD is the continuous activation of the mucosa-associated immune system; the disease has two major forms of presentation: ulcerative colitis and Crohn´s disease. The extraintestinal manifestations are present in 36% of patients, and any organ can be affected. There is an imbalance between proinflammatory and antinflammatory cytokines leading to a systemic disease. The rheumatologic manifestations of the IBD are: Peripheral arthritis, spondyloarthropathy and a third category that includes dermic and ocular lesions as well as metabolic bone disease. Control of the extraintestinal manifestations is based on systemic therapy with steroids, 5-ASA derivatives and biological anti-TNF therapy.

  17. Biomecánica del codo y sus implicaciones en el diseño de recambios articulares

    OpenAIRE

    Antuña, S.

    2004-01-01

    Los resultados de la artroplastia de codo han mejorado sustancialmente coincidiendo con el mejor conocimiento de la biomecánica del codo. El diseño y los resultados clínicos de las prótesis de codo se basan en un conocimiento preciso de la cinemática, los estabilizadores y las fuerzas que atraviesan esta articulación.

  18. Tratamiento psicológico protocolizado en grupo de las enfermedades inflamatorias intestinales: efectos sobre la calidad de vida

    OpenAIRE

    Miguel Ángel Díaz-Sibaja; María Isabel Comeche-Moreno; Blanca Mas-Hesse; Marta Díaz García; Miguel Ángel Vallejo Pareja

    2008-01-01

    La enfermedad inflamatoria intestinal (EII) es una enfermedad crónica que afecta notablemente a la calidad de vida del paciente. El principal objetivo de este estudio fue demostrar la eficacia de un programa de tratamiento psicológico protocolizado para mejorar la calidad de vida de estos pacientes. La muestra estuvo constituida por 57 pacientes diagnosticados de EII (33 programa de tratamiento en grupo y 24 grupo control en lista de espera). Las variables dependientes fueron: síntomas digest...

  19. Estudio Transversal sobre la Relación entre Neuroticismo y Curso Clínico en Pacientes con Enfermedades Inflamatorias Intestinales

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    Juan Carlos Fernández Méndez

    2010-01-01

    Full Text Available En el presente trabajo se analiza la relación que existe entre neuroticismo y diversas condiciones médicas que hacen referencia al curso clínico de las enfermedades inflamatorias intestinales. Para desarrollar la investigación se tomaron medidas en neuroticismo mediante el Inventario de Personalidad de Eysenck a 106 participantes diagnosticados de colitis ulcerosa y enfermedad de Crohn. Los resultados reflejaron que la muestra global de pacientes con enfermedades inflamatorias intestinales mostraba valores en neuroticismo que se hallaban dentro de la normalidad; sin embargo, se pudo verificar que los valores diferían dependiendo del curso clínico de la patología. El estudio sugiere que las variaciones en neuroticismo son considerables cuando se analizan los datos de la muestra general y cuando se tienen en cuenta diversas condiciones del curso clínico.

  20. Modelos animales para el estudio de la respuesta inflamatoria sistémica y de nutrición parenteral Animal models for the study of systemic inflammatory response and parenteral nutrition

    OpenAIRE

    J. M. Morán Penco

    2007-01-01

    El Síndrome de Respuesta Inflamatoria Sistémica (SRIS) parece desencadenarse por la activación de un tipo de receptores llamados Toll-Like, propios de las células de respuesta inflamatoria y que, a través de señales citosólicas específicas, producen una cascada de reacciones que activan las Citocinas, Factores de Crecimiento y otros mediadores inflamatorios. En este trabajo, repasamos y discutimos varias clasificaciones de Modelos Animales para el estudio del SRIS y proponemos que estos model...

  1. Efficacy of intravenous iron in treating iron deficiency anaemia in patients with inflammatory bowel disease: Are there predictors of response? Eficacia del hierro intravenoso en el tratamiento de la anemia ferropénica en pacientes con enfermedad inflamatoria intestinal: ¿Existen factores predictivos de respuesta?

    Directory of Open Access Journals (Sweden)

    Rocío Ferreiro Iglesias

    2011-05-01

    Full Text Available Introduction: in inflammatory bowel disease (IBD iron deficiency anaemia (IDA is a very common disorder. Until recently, oral iron has been the mainstay therapy, nevertheless it has been associated with intolerance and noncompliance. Therefore, the goal of our study was to evaluate the efficacy of intravenous iron in IDA in IBD patients and the secondary aim was to investigate whether other potential factors could influence in the response to the treatment. Design: an open-label, prospective, consecutive, single centre study. Material and methods: we performed our study in patients with ulcerative colitis (UC or Crohn's disease (CD with severe anaemia or intolerance with oral iron. All of them received intravenous sacarose iron and did biochemistry profile with haemoglobin (Hb. Moreover, the correlation with other variables was studied: age, sex, smoking habit, IBD type, previous surgery and type of surgery and other treatments. Response was defined as Hb increase of ≥ 2 g/dL or normalization of the levels. Results: fifty-four patients were included into the study, 34 (63% with UC y 20 (37% with CD, 18 (33.3% men and 36 women (66.6% and the average was 48 ± 14 years. The total proportion of responders was 52% (SD ± 05; 43% of the patients reached Hb ≥ 2 g/dl and y 9% of them normalized Hb. Only the utilization of 5-ASA was associated with low response to iron treatment (p Introducción: la anemia por déficit de hierro es un problema frecuente en la enfermedad inflamatoria intestinal (EII. Un número no despreciable de pacientes no responde o presenta intolerancia al hierro oral. El objetivo de nuestro estudio es evaluar la eficacia del hierro sacarosa intravenoso (Venofer® en los pacientes con EII así como los potenciales factores que pueden influir en la respuesta al mismo. Diseño: estudio abierto, unicéntrico y con una inclusión consecutiva de casos. Material y métodos: se incluyeron pacientes con colitis ulcerosa (CU y enfermedad

  2. Recomendaciones de vacunación en pacientes con enfermedad inflamatoria intestinal (EII

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    C. Rodríguez

    2013-04-01

    Full Text Available El concepto de enfermedad inflamatoria intestinal (EII engloba tres entidades: la colitis ulcerosa (CU, la enfermedad de Crohn (EC y la colitis inclasificable (CI. Estas enfermedades tienen en común el curso crónico y recidivante, alternando épocas de marcada actividad inflamatoria con otras quiescentes, en las que el paciente permanece asintomático. Durante muchos años la base del tratamiento, sobre todo en las fases agudas, se basó en el uso de corticoides. Sin embargo, a lo largo de las últimas décadas hemos asistido a avances importantes desde el punto de vista terapéutico. Así se estima que, a lo largo de la evolución de la enfermedad, el 80% de los pacientes van a precisar corticoides, el 40% inmunomoduladores (IMM y hasta un 20% necesitará un fármaco biológico para el control de su enfermedad. Si bien todo ello se acompaña de una mejora en la calidad de vida, disminuyendo la necesidad de ingresos e intervenciones quirúrgicas, su uso implica también un incremento en el riesgo de sufrir infecciones, bien por gérmenes habituales en la comunidad o por gérmenes oportunistas. Las infecciones, además, son causa de morbimortalidad asociada a EII y algunas de ellas son prevenibles con vacunas, de ahí la importancia que los programas de vacunación están adquiriendo en este grupo de pacientes. Presentamos una revisión de la literatura al respecto y proponemos unas recomendaciones de vacunación para los pacientes diagnosticados de EII.

  3. Tratamiento psicológico protocolizado en grupo de las enfermedades inflamatorias intestinales: efectos sobre la calidad de vida

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Díaz-Sibaja

    2008-01-01

    Full Text Available La enfermedad inflamatoria intestinal (EII es una enfermedad crónica que afecta notablemente a la calidad de vida del paciente. El principal objetivo de este estudio fue demostrar la eficacia de un programa de tratamiento psicológico protocolizado para mejorar la calidad de vida de estos pacientes. La muestra estuvo constituida por 57 pacientes diagnosticados de EII (33 programa de tratamiento en grupo y 24 grupo control en lista de espera. Las variables dependientes fueron: síntomas digestivos, síntomas sistémicos, afectación funcional, función emocional y afectación social (Cuestionario de calidad de vida en la enfermedad inflamatoria intestinal (SIBDQ, López-Vivancos y cols., 1999. Los resultados revelan que el programa de tratamiento psicológico resultó eficaz para producir una mejoría significativa en todas las variables de calidad de vida a la finalización del mismo, al compararlo con el grupo control en lista de espera. Si bien las diferencias se mantienen en 4 de los 5 aspectos evaluados a los 3 meses de seguimiento, a los 12 sólo se mantienen las diferencias en uno de ellos.

  4. Manifestaciones orales y periodontales de la enfermedad inflamatoria intestinal

    OpenAIRE

    2001-01-01

    La Enfermedad Inflamatoria Intestinal (EII) incluye la enfermedad de Crohn y la colitis ulcerosa. Numerosos estudios relacionan dichas afectaciones con la manifestación de determinadas lesiones orales. Respecto a la enfermedad periodontal algunos autores la correlacionan con la EII tanto en su prevalencia como en su grado de actividad. Se ha apuntado la alteración de los PMN como posible factor común en la patogénesis de ambas entidades. El propósito de nuestro artículo es revisar las manifes...

  5. Eficácia analgésica do uso de dose alta de morfina intra-articular em pacientes submetidos à artroplastia total de joelho Eficacia analgésica del uso de dosis alta de morfina intra-articular en pacientes sometidos a la artroplastia total de rodilla Analgesic efficacy of the intra-articular administration of high Doses of morphine in patients undergoing total knee arthroplasty

    Directory of Open Access Journals (Sweden)

    João Batista Santos Garcia Garcia

    2010-02-01

    demostrado que las dosis mayores generan mejores resultados y consecuentemente, un menor consumo postoperatorio de analgésico, caracterizando así, el efecto dosis-dependiente en la acción periférica. Fue realizado un estudio controlado, aleatorio y doble ciego para evaluar la eficacia de 10 mg de morfina por vía intraarticular en pacientes sometidos a la artroplastia total de rodilla. MÉTODO: Se evaluaron 50 pacientes sometidos a la artroplastia total de rodilla, distribuidos aleatoriamente en dos grupos: el grupo tratamiento recibió 10 mg (1 mL de morfina por vía intra-articular diluido en 19 mL de solución fisiológica al 0,9% (SF, mientras que el grupo control recibió una inyección intra-articular con 20 mL de SF, ambos después del cierre de la cápsula articular, al final de la operación. La morfina subcutánea bajo demanda, estuvo disponible para el dolor residual. Se evaluaron las siguientes variables: intensidad del dolor graduada en la Escala Numérica (EN a las 2h (M1, 6h (M2, 12h (M3 y 24h (M4, después de la inyección IA; tiempo para la primera solicitación de analgésico; y consumo de analgésicos y efectos adversos. CONCLUSIONES: El grupo tratamiento presentó menores valores en la EN que el grupo control en M1 y M2, mientras que en los otros momentos, no se registró ninguna diferencia significativa. El intervalo para la primera solicitación de analgésicos fue significantemente mayor en el grupo tratamiento y el consumo de analgésicos en las primeras 24 horas fue menor en ese grupo. No hubo diferencia entre la incidencia de efectos adversos entre los grupos. Llegamos a la conclusión, de que 10 mg de morfina redujeron el dolor del postoperatorio entre 2 y 6 horas después de aplicada la inyección IA, y se generó un periodo mayor sin analgésico de rescate reduciendo su consumo en las primeras 24 horas.BACKGROUND AND OBJECTIVES: Although the efficacy of intraarticular (IA morphine is still controversial, it has been shown that higher doses

  6. Nutrición y enfermedad inflamatoria intestinal Nutrition and inflammatory bowel disease

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    E. Cabré Gelada

    2007-05-01

    Full Text Available En este artículo se revisan las causas y consecuencias de los déficits nutricionales en la enfermedad inflamatoria intestinal, con especial énfasis en sus implicaciones fisiopatológicas. Además, se sientan las bases de la intervención nutricional en estos pacientes tanto desde la perspectiva del consejo dietético como del uso de soporte nutricional especializado. Se hace un especial hincapié en la discusión de las evidencias existentes en favor de un papel terapéutico primario de la nutrición artificial y algunos nutrientes específicos en la enfermedad de Crohn.In this paper, the causes and consequences of nutritional deficiencies in inflammatory bowel disease are reviewed. Particular emphasis is made on their pathophysiological implications. In addition, the basis for nutritional intervention in these patients are described (both in terms of dietary counseling and the use of specialized nutritional support. Particular mention is made on the current evidences in favour of a primary therapeutic role of artificial nutrition and some specific nutrients in Crohn's disease.

  7. Condrocalcinose articular familiar Familial articular chondrocalcinosis

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    Mittermayer Barreto Santiago

    2004-08-01

    Full Text Available Condrocalcinose articular familiar é uma condição clínica caracterizada pela deposição de cristais de pirofosfato de cálcio no líquido sinovial e cartilagens articulares levando à artrite. Descrevemos três membros de uma família com condrocalcinose cujo quadro clínico era caracterizado por artrite intermitente em dois e artrite crônica lembrando artrite reumatóide em um. A avaliação radiológica mostrou calcificações em cartilagens de diversas articulações, particularmente de joelhos. A utilização de colchicina foi suficiente para prevenir as crises de artrite em dois pacientes e o paciente com a forma crônica necessitou uso contínuo de antiinflamatórios não-hormonais. Embora aparentemente rara no Brasil, não afastamos a possibilidade desse dado estar subestimado e sugerimos que seja realizada uma avaliação radiológica articular dos familiares de todo paciente com diagnóstico de condrocalcinose esporádica.Familial articular chondrocalcinosis is a disorder characterized by deposition of calcium pyrophosphate dihydrate crystal in synovial fluid and articular cartilage that can cause joint pain and arthritis. We have identified three members of the same family with chondrocalcinosis. The clinical features of the disease were intermittent episodes of arthritis in two patients and polyarthritis resembling rheumatoid arthritis in one member. The radiological evaluation showed calcification in several joints, particularly in cartilages of the knees. Therapy with colchicine was enough to prevent arthritic crisis in two patients and continous NSAID use was necessary to control symptoms in the last one. Familial chondrocalcinosis seems to be rare in Brazil, but we do not exclude the possibility that this figure is underestimated and suggest that in cases of sporadic chondrocalcinosis other members of the family should be fully investigated.

  8. Eficacia histopatológica en la fase inflamatoria, proliferativa y osteogénica en la cicatrización alveolar post exodoncia aplicando matico (Piper angustifolium)

    OpenAIRE

    Pérez, Aurelia

    2016-01-01

    El presente estudio tiene como finalidad determinar la eficacia histopatológica en la fase inflamatoria, proliferativa y osteogénica de la cicatrización post exodoncia tratadas con Matico (Piper angustifolium). El estudio fue experimental, tuvo por finalidad saber el nivel de cicatrización histopatológica del Matico (Piper angustifolium) dentro de los alveolos post exodoncia, con un grupo de estudio de 15 conejos machos con un peso de 2.5 Kg, divididos en grupo control y grupo experimental (s...

  9. Cooperación oncogénica entre la citoquina pro-inflamatoria SP y el receptor tirosina quinasa ErbB-2/HER2

    OpenAIRE

    Garcia Recio, Susana

    2012-01-01

    INTRODUCCIÓN: La inflamación es un sello distintivo del cáncer. La inflamación crónica está fuertemente relacionada con el desarrollo y la progresión tumoral y suministra al tumor múltiples citoquinas proinflamatorias que pueden modular la señalización de la célula tumoral. Este es el caso de la Sustancia P (SP), una citoquina pro-inflamatoria/neuropéptido presente en el microambiente tumoral perteneciente a la familia de las taquiquininas y que señaliza principalmente a través de su receptor...

  10. Pelvic inflammatory disease Enfermedad inflamatoria pélvica

    Directory of Open Access Journals (Sweden)

    Regla Fang Mederos

    2007-02-01

    Full Text Available

    A bibliographical revision on the main topics referred to the acute pelvic inflammatory disease which includes definition, risk factors, diagnosis, and treatment with the objective to create a supporting educational aid to the teaching of students of 4th and 6th year of the medicine and nursing specialty in their rounds on the services of gynecology and obstetrics.

    Revisión bibliográfica sobre los principales temas referidos a la enfermedad inflamatoria pélvica aguda que incluye concepto, factores de riesgo, cuadro clínico, diagnóstico y tratamiento, con el objetivo de crear un material de apoyo a la docencia de estudiantes de cuarto y sexto año de la especialidad de medicina y de enfermería en su rotación por los Servicios de Ginecología y Obstetricia.

  11. [Intra-articular injections].

    Science.gov (United States)

    Chapelle, Ch

    2015-09-01

    It is not unusual for a specialist or general practitioner to be presented with a pathology which necessitates the use of an intra-articular injection of corticosteroids, hyaluronic acid or a local anaesthetic. It would seem to be interesting to update and to precise the techniques and methods of intraarticular injections which have appeared in recent international publications, when we know that 30 % of the injections given into the knee and so called "dry" are incorrect and, therefore, inefficient. The indication of an articular injection depends, firstly, on the diagnosis which should be done with great care; after which should be an objective analysis complete with secondary effects linked to both the injection and the product used. The conditions of asepsis, the choice of needles and quantities of the injection and even the ways of the injections should be reviewed in detail. The last studies clearly question the secondary effects of the cartilage degradations of the cortisone given as an intra-articular injection and shows its efficiency on the pain and inflammatory phenomonen in osteoarthritis. Studies on hyaluronic acid are often contradictory going from a modest result to an important pain relief but it is necessary to be aware that the objective criteria are difficult to interpret. The use of local anaesthetics in intra-articular is limited by the few indications in view of the major risk of aggravating the pre-existing lesions by the disappearing signs of pain.

  12. Hiperplasia Fibrosa Inflamatoria: reporte de un caso Inflammatory Fibrous Hyperplasia: case report

    Directory of Open Access Journals (Sweden)

    A Casian Romero

    2011-08-01

    Full Text Available Introducción: La Hiperplasia Fibrosa Inflamatoria es una alteración caracterizada por un agrandamiento del tejido conectivo; se considera una lesión reactiva ya que se presenta como respuesta a una irritante crónico local; es una lesión común en pacientes adolescentes y de edad adulta debido a que su etiología principal se asocia a maloclusión, al uso de aparatología protésica u ortodóntica mal ajustada, así como a la presencia de biofilm. Sin embargo, la población infantil, principalmente en dentición mixta, no está exenta de presentar esta alteración, aunque en menor proporción. Objetivo: Presentar el caso clínico de un paciente en dentición mixta que presenta una Hiperplasia Fibrosa Inflamatoria con el fin de presentar las características clínicas e histopatológicas de la lesión, enfatizando la importancia de un temprano y correcto diagnóstico. Presentación del Caso: Paciente masculino de 8 años de edad que se presenta a la clínica por presentar lesiones cariosas y malposición dental. A la exploración se observa un agrandamiento gingival localizado, en el órgano dentario 41. Se decide tomar una biopsia de la lesión para establecer el diagnóstico. Conclusión: Debido a que existen varias lesiones con características clínicas muy similares a las que presentaba el paciente, es necesario conocer los diagnósticos diferenciales, así como realizar el diagnóstico temprano de la lesión para poder llevar a cabo un tratamiento eficaz y adecuado.Introduction: The Inflammatory Fibrous Hyperplasia (IFH is a disorder consisting in a connective tissue overgrowth; it is considered a reactive lesion because it appears in response to a chronic and local irritant; this is a very common oral lesion in adolescents and adults, its etiology is associated with dental malocclusion, use of over-extended prosthetic and orthodontic appliances, and with the presence of biofilm (plaque. Nevertheless, child population, mainly patients

  13. Enfermedad inflamatoria intestinal: situación actual de las alternativas terapéuticas

    Directory of Open Access Journals (Sweden)

    Lucrecia Suárez

    2007-03-01

    Full Text Available La enfermedad inflamatoria intestinal (EII se caracteriza por tener un curso clínico impredecible alternando recaídas con períodos de inactividad, una respuesta muy variable a la terapia y la constante aparición de complicaciones diversas. Su manejo es particularmente complejo en el niño y si bien existen diferentes guías y recomendaciones disponibles, los ensayos clínicos realizados en este grupo de edad son limitados y la evidencia científica es contradictoria, por lo cual aún no se cuenta con un consenso terapéutico aceptado internacionalmente. Los objetivos generales del tratamiento consisten en inducir y mantener la enfermedad en remisión el mayor tiempo posible, conseguir un adecuado crecimiento y prevenir posibles complicaciones. En años recientes, la aparición de nuevas alternativas terapéuticas ha permitido darle un enfoque más integral al manejo de estos pacientes tomando también en consideración el estado nutricional y psicológico además de su calidad de vida. Estos tratamientos, si bien consiguen en muchos casos controlar la inflamación intestinal curando las lesiones de la mucosa, no están exentos de efectos secundarios a corto y largo plazo, motivo por el cual es imprescindible tomar en cuenta las características de cada paciente para poder ofrecer un tratamiento individualizado que sea capaz de modificar la evolución natural de la enfermedad.

  14. Tratamiento nutricional en la enfermedad inflamatoria intestinal Nutritional management of inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    C. Pérez Tárrago

    2008-10-01

    Full Text Available Los pacientes con enfermedad inflamatoria intestinal presentan mayor riesgo de malnutrición. Por este motivo es muy frecuente que se precise un adecuado soporte nutricional. En estos pacientes se debe utilizar la nutrición enteral a menos que existan contraindicaciones. El soporte nutricional como tratamiento primario no está indicado en adultos (al haberse demostrado una mayor eficacia del tratamiento esteroideo salvo en caso de intolerancia o falta de respuesta al tratamiento médico. Por el contrario, la nutrición enteral se considera el tratamiento de primera línea en niños. No existe un claro beneficio con el uso de fórmulas específicas (grasa modificada, glutamina... por lo que no se aconseja su uso rutinario. A pesar de los grandes avances técnicos y científicos existen aún numerosos campos en los que ampliar conocimientos; algunos de los mismos se esbozan en la presente publicación.Patients with inflammatory bowel disease present higher risk for hyponutrition. For this reason, an adequate nutritional support is frequently needed. In these patients, enteral nutrition should be used unless there exist contraindications. Nutritional support as the primary therapy is no indicated in adults (since steroidal therapy has shown to be more effective but in the case of intolerance or lack of response to medical treatment. By contrast, enteral nutrition is considered a first line therapy in children. There is no clear benefit with the use of specific formulas (modified fat, glutamine..., so that their routine use is not recommended. In spite of the great technical and scientific advances, there are still many fields in which knowledge should be broaden; some of them are pointed out in this publication.

  15. Respuesta inflamatoria esplácnica en la colestasis microquirúrgica experimental

    OpenAIRE

    García Domínguez, José

    2008-01-01

    La colestasis extrahepática en la rata cursa con alteraciones esplácnicas y sistémicas en cuya producción podrían estar implicados mecanismos patogénicos de naturaleza inflamatoria. Con el objeto de caracterizar el tipo de respuesta inflamatoria esplácnica secundaria a la colestasis obstructiva, se utilizó un modelo experimental de colestasis extrahepática microquirúrgica, para estudiar en una fase evolutiva considerada crónica, la concentración de citoquinas tipo Th1 (TNFα e IL-1) y Th2 (...

  16. El concepto de contacto articular alternativo de la rodilla

    OpenAIRE

    1994-01-01

    La observación radioscópica de la interlínea articular de rodillas de cadáveres sin anomalías anatómicas durante movimientos de abducción y adducción, realizada en estudios previos del autor, permitió apreciar la aparición de pérdida de contacto entre las superficies articulares mediales o laterales respectivamente. El presente artículo tuvo como objetivo rememorar dichos estudios y documentar las apreciaciones visuales mediante el análisis de neumoartrografías seriada...

  17. Nuevos mecanismos protectores en la enfermedad inflamatoria intestinal sistema endocannabinoide y haptoglobina /

    OpenAIRE

    Márquez Mosquera, Lucía

    2012-01-01

    La Enfermedad Inflamatoria Intestinal (EII) (enfermedad de Crohn (EC) y Colitis Ulcerosa (CU)), es una enfermedad crónica, poligénica y compleja, de curso recurrente, que afecta al tracto gastrointestinal. Estudios recientes in vitro y modelos experimentales en animales sugieren que el Sistema Endocannabinoide (SE) y la Haptoglobina (Hp) pueden tener un papel protector en la EII. Estudio 1: Sistema Endocannabinoide y EII Se analizó, mediante Western-Blot e inmunohistoquímica, la presencia de ...

  18. Citocinas anti-inflamatorias y sus acciones y efectos en la sepsis y el choque séptico (Anti-inflammatory cytokines and their actions and effects in the sepsis and septic shock.

    Directory of Open Access Journals (Sweden)

    González Álvarez, Ricardo

    2009-08-01

    Full Text Available ResumenLas citocinas anti- inflamatorias reconocidas son las interleucinas (IL IL-4, IL-10, IL-6, IL-13, el factor estimulante de colonia granulocito –macrófago (FEC-GM y el interferón alfa (IFN-alfa, los cuales tienen la capacidad de inhibir la liberación de las citocinas pro-inflamatorias y de inducir la producción del antagonista del receptor de la IL-1 y la liberación del receptor soluble del FNT, los cuales limitan algunas de las actividades de las citocinas pro-inflamatorias IL-1 y FNT-α. Sin embargo, los eventos que ocurren durante la inflamación y la sepsis no son tan simples como parajustificar siempre acciones antagonistas entre las citocinas proinflamatorias y las anti-inflamatorias, las cuales, pueden tener acorde con las circunstancias un comportamiento dual y/o antagónico en el choque séptico. Así por ejemplo la IL-10 tiene propiedades anti-inflamatorias, lo cual ocurre en la diabetes auto-inmune cuyo comienzo y desarrollo son acelerados en ratones transgénicos que sobre-expresan la IL-10 en los islotes pancreáticos. Esto también ocurre con la IL-10 en un modelo de uveítis en el que se incrementó la inflamación ocular. Ejemplos como los anteriores son extensivos a otras citocinas anti-inflamatorias como la IL-4, IL-13, el factor estimulante de colonia granulocito –macrófago y el factor beta transformante del crecimiento (FβTC, y que serán mencionadas y descritas en el presente artículo de revisión, así como los factores que determinan ese comportamiento dual de las citocinas.Summaryinterleucinas. The anti-inflammatory cytokines which are recognized are the interleukins (IL IL-4, IL-10, IL-13, interferon-alpha (IFN-α and because they are able to inhibit the release of pro inflammatory cytokines, to induce the production of IL-1 receptor antagonist (IL-ra and the release of soluble TNF receptor and to limit some of the pro-inflammatory activities of IL-1 and TNF. However the events which occur during

  19. Donador exógeno de óxido nítrico en la respuesta inflamatoria hepática y hemodinámica después de choque hemorrágico

    OpenAIRE

    Roberto Anaya-Prado; Toledo-Pereyra, Luis H; Ren Feng Guo; Jayne Reuben; Ward, Peter A.

    2008-01-01

    Introducción: El choque hemorrágico resulta en estrés oxidativo celular e inducción de respuesta inflamatoria. Investigamos la capacidad del nitroprusiato de sodio para reducir la lesión tisular en un modelo animal de choque hemorrágico no controlado. Material y métodos: 72 ratas Sprague-Dawley distribuidas en cuatro grupos: sham/salina, sham/nitroprusiato de sodio, choque/ salina, choque/nitroprusiato de sodio. Se provocó choque hemorrágico (3 ml/100 g) en un periodo de 15 minutos; corte de ...

  20. Caracterización de la respuesta inflamatoria en la neumonía comunitaria grave. Efecto de los corticoides en la contención de dicha respuesta y en el curso evolutivo de la infección

    OpenAIRE

    Fernández Serrano, Silvia

    2012-01-01

    [spa] La neumonía adquirida en la comunidad (NAC) continúa siendo en la actualidad una enfermedad potencialmente grave, que con frecuencia presenta una evolución desfavorable, a pesar del tratamiento antibiótico adecuado. La hipótesis de la tesis plantea que es posible monitorizar la respuesta inflamatoria que tiene lugar durante la NAC y, que dicha respuesta, puede ser influenciada por los antibióticos utilizados en su tratamiento, así como modulada mediante una terapia adyuvante con co...

  1. Caracterización de la Artritis reumatoidea en el consultorio de especialidades del ISSS

    OpenAIRE

    2012-01-01

    La Artritis Reumatoidea (AR)es una enfermedad inflamatoria crónica, poliarticular e incapacitante. En la consulta de Reumatologia del Consultorio de Especialidades del Instituto Salvadoreño del Seguro Social(ISSS), es una de las principales causas de consulta y es responsable de muchas discapacidades y muertes prematuras.

  2. Actividad inflamatoria en múltiples placas ateroscleróticas en pacientes fallecidos por infarto agudo de miocardio

    Directory of Open Access Journals (Sweden)

    Alejandro García Escudero

    2009-01-01

    Full Text Available IntroducciónEstudios clínicos y anatomopatológicos sugieren que los procesos inflamatorios tienen un papel importante en la inestabilidad de la placa aterosclerótica, dado que en pacientes con síndromes coronarios agudos se observan infiltrados inflamatorios difusos en las arterias coronarias.ObjetivosEvaluar y localizar la distribución de placas vulnerables e infiltrados inflamatorios en pacientes fallecidos por infarto agudo de miocardio.Material y métodosMediante microscopia óptica se estudiaron las arterias coronarias de 58 pacientes fallecidos por infarto de miocardio. En las arterias coronarias relacionadas con el infarto y en las no relacionadas se registraron las siguientes variables: presencia de trombo, rotura de placa, hemorragia intraplaca y presencia de infiltrado inflamatorio.ResultadosAl analizar las diferencias existentes entre las arterias responsables del infarto y en las no responsables se encontraron diferencias significativas con respecto a la presencia de trombo (69% versus 38%; p < 0,008 y de hemorragia intraplaca (69% versus 50%; p < 0,03. No se encontró una diferencia significativa entre la arteria responsable y la no responsable al evaluar la presencia de infiltrado inflamatorio en las placas ateroscleróticas (77% versus 71%; p = ns.ConclusiónEn el infarto agudo de miocardio se comprobó la presencia de actividad inflamatoria que afectaba a más de un vaso, con compromiso de otras arterias además de la responsable del infarto. Se detectó también accidente agudo de placa en más de una arteria coronaria.REV ARGENT CARDIOL 2009;77:81-87.

  3. Comparación de los efectos de dos técnicas de electroanalgesia en la enfermedad articular degenerativa tarsometatarsiana del equino Comparison between the effects of two electroanalgesical technics in the tarsometatarsal degenerative joint disease

    Directory of Open Access Journals (Sweden)

    J.A. García Liñeiro

    2006-12-01

    Full Text Available Se realizó una experiencia para comparar los resultados analgésicos entre TENS (cuyas siglas derivan de la expresión en inglés: transcutaneus electrical neuromuscular stimulation y el EMAR (estimulación mecánica por acción refleja de efectividad comprobada en medicina equina, sobre un modelo clínico de 10 equinos afectados por enfermedad articular degenerativa tarsometatarsiana con un protocolo diagnóstico estandarizado. Sobre la misma población se hicieron los dos tratamientos con intervalos de 6 meses entre uno y otro comparándose luego los resultados. Las aplicaciones en cada tratamiento fueron diarias y el control clínico se realizó post-tratamientos cada dos días (5 controles totales por los mismos tres profesionales para mantener el mismo esquema de evaluación, considerándose como parámetros: a- Trote en línea recta y en círculo, terreno blando y duro b­Flexión forzada c- Test del tarso (test de Churchill. Se realizó la prueba de Mc Nemar para comparar los grados de claudicación y respuestas a la flexión forzada, observados durante el 5to control, obtenidos luego de aplicar EMAR y TENS, y no se encontraron diferencias significativas entre ambos tratamientos (p=0,2568. También, se comparó el resultado del Test del Tarso (Test de Churchill luego de aplicar EMAR y TENS, con la prueba de Mc Nemar, no encontrándose diferencias significativas entre ambos (p= 0,7055. Se determina que hay muy poca diferencia entre ambos tratamientos fisioterápicos, observándose una disminución importante a partir del control 2. De estos resultados podemos inferir que ambos métodos pueden utilizarse con éxito en forma indistinta, seleccionándolos de acuerdo con las ventajas y desventajas de su aplicación.A clinical model was designed in order to compare the analgesic effects of TENS (transcutaneous electrical neuromuscular stimulation and RAME (reflex action mechanical electrostimulation, since both methods have been proven

  4. Adherence to treatment in inflammatory bowel disease Adhesión al tratamiento en la enfermedad inflamatoria intestinal

    Directory of Open Access Journals (Sweden)

    A. López San Román

    2005-04-01

    Full Text Available Aim: adherence to therapy is important to ensure success. We wanted to explore this feature in patients with inflammatory bowel disease. Patients and methods: we explored adherence to treatment and its modifiers in 40 patients with inflammatory bowel disease using a battery of tests. Results: a 67% of patients (95% CI: 51-81% acknowledged a certain degree of involuntary nonadherence, and 35% (95% CI: 20-51% of voluntary nonadherence. Overall, 72% (95% CI: 56-85% of patients had some form of nonadherence. An objective correlation of these self-reported data was assessed by the determination of urine salicylate levels in the subset of patients treated with mesalazine or its derivatives (15 cases. Two of them (13% had no detectable urinary drug levels, indicating complete nonadherence. Voluntary nonadherence was higher in patients with lower scores in the intestinal (p = 0.02 and social areas (p = 0.015 of IBDQ-32, as well as in those with less active Crohn's disease (p Objetivo: la adhesión al tratamiento es importante para el éxito del mismo. Quisimos conocer este dato en pacientes con enfermedad inflamatoria intestinal. Pacientes y métodos: hemos explorado la adhesión al tratamiento y sus condicionantes en 40 pacientes con enfermedad inflamatoria intestinal, aplicando una batería de pruebas. Resultados: un 67% (IC 95%: 51-81% de los pacientes presentaba algún grado de falta involuntaria de adhesión. A su vez, un 35% (20-51% de los pacientes presentaba algún grado de falta voluntaria de adhesión. Globalmente, un 72% (56-85% de los pacientes presentó uno u otro tipo de falta de adhesión. El correlato objetivo, se obtuvo mediante la determinación de salicilatos en orina en el subgrupo de pacientes bajo tratamiento con mesalazina o derivados (15 casos. Dos de ellos (13%, no tenían niveles detectables, traduciendo falta absoluta de adhesión al tratamiento. La adhesión intencionada era tanto más baja cuanto menores eran las

  5. La reacción inflamatoria en la fisiopatogenia de la obesidad

    OpenAIRE

    Ma Victoria Domínguez García; Gerardo Gabriel Huitrón Bravo; Anaí A. Mendoza López

    2012-01-01

    La obesidad se caracteriza por inflamación crónica. Entre los biomarcadores de inflamación encontramos las citocinas producidas por los adipocitos y los macrófagos: TNF - a, IL - 6, leptina, adiponectina y resistina. La relación adipocito-macrófago impacta la respuesta inflamatoria observada en la obesidad, la cual tiene una relación directa con la cantidad de macrófagos acumulados en el tejido adiposo blanco, que contribuye a la producción de mediadores de la inflamación. En este documento s...

  6. Miopatía inflamatoria con compromiso inicial de músculos respiratorios y artritis reumatoidea

    OpenAIRE

    Martín Hunter; Irene Telias; Victoria Collado; Judith Sarano; Clarisa Álvarez; Juan Pablo Suárez

    2014-01-01

    Las miopatías inflamatorias constituyen un grupo heterogéneo de enfermedades musculares adquiridas de presentación subaguda, crónica y a veces aguda. Las entidades clínicas más frecuentes son la dermatomiositis, la polimiositis, la miositis necrotizante autoinmune y la miositis por cuerpos de inclusión. Suelen presentarse con debilidad muscular con predominio proximal y simétrica, pero rara vez comprometen los músculos respiratorios. Presentamos el caso de una mujer de 39 años con miopatía in...

  7. CORIOAMNIONITIS HISTOLÓGICA Y MORBIMORTALIDAD NEONATAL: APROXIMACIÓN AL SÍNDROME DE RESPUESTA INFLAMATORIA FETAL

    OpenAIRE

    Rincón Ricote,M. Inmaculada; Magdaleno Dans, Fernando; Sancha Naranjo,Marta; Omeñaca Teres,Félix; González González,Antonio

    2010-01-01

    Antecedentes: El síndrome de respuesta inflamatoria fetal (SRIF) es una entidad relacionada con la presencia de inflamación intrauterina y suele asociarse a infección intraamniótica. Su consecuencia más grave es la lesión cerebral y posterior desarrollo de parálisis cerebral. Objetivo: Evaluar la relación entre el síndrome de respuesta inflamatoria fetal y el desarrollo de complicaciones neonatales. Método: Estudio descriptivo y retrospectivo, realizado en el Hospital Universitario La Paz de ...

  8. Enfermedad inflamatoria pélvica: un reto en el diagnóstico y tratamiento precoz

    OpenAIRE

    Baquedano Mainar,Laura; Lamarca Ballestero,Marta; Puig Ferrer,Fernando; Ruiz Conde,Miguel Angel

    2014-01-01

    Objetivo: Actualizar los datos disponibles en referencia a la enfermedad inflamatoria pélvica para poder unificar criterios diagnósticos y terapéuticos y así minimizar las complicaciones que a corto y/o largo plazo puedan derivar. Método: Revisión de la literatura en Pubmed atendiendo sobre todo a las guías clínicas más actualizadas y ensayos clínicos aleatorizados. Resultados: La enfermedad inflamatoria pélvica es un cuadro infeccioso común entre las mujeres en edad fértil. Su mecanismo de t...

  9. Citocinas anti-inflamatorias y sus acciones y efectos en la sepsis y el choque séptico - Anti-inflammatory cytokines and their actions and effects in the sepsis and septic shock

    Directory of Open Access Journals (Sweden)

    González Álvarez, Ricardo

    2009-09-01

    Full Text Available ResumenLas citocinas anti- inflamatorias reconocidas son las interleucinas (ILIL-4, IL-10, IL-6, IL-13, el factor estimulante de colonia granulocito – macrófago (FEC-GM y el interferón alfa (IFN-alfa, los cuales tienen la capacidad de inhibir la liberación de las citocinas pro-inflamatorias y de inducir la producción del antagonista del receptor de la IL-1 y la liberación del receptor soluble del FNT, los cuales limitan algunas de las actividades de las citocinas pro-inflamatorias IL-1 y FNT-α. Sin embargo, los eventos que ocurren durante la inflamación y la sepsis no son tan simples como para justificar siempre acciones antagonistas entre las citocinas pro-inflamatorias y las antiinflamatorias, las cuales, pueden tener acorde con las circunstancias un comportamiento dual y/o antagónico en el choque séptico. Así por ejemplo la IL-10 tiene propiedades anti-inflamatorias, lo cual ocurre en la diabetes auto-inmune cuyo comienzo y desarrollo son acelerados en ratones transgénicos que sobre-expresan la IL-10 en los islotes pancreáticos. Esto también ocurre con la IL-10 en un modelo de uveítis en el que se incrementó la inflamación ocular. Ejemplos como los anteriores son extensivos a otras citocinas antiinflamatorias como la IL-4, IL-13, el factor estimulante de colonia granulocito –macrófago y el factor beta transformante del crecimiento (FβTC, y que serán mencionadas y descritas en el presente artículo de revisión, así como los factores que determinan ese comportamiento dual de las citocinas.SummaryThe anti-inflammatory cytokines which are recognized are theinterleukins (IL IL-4, IL-10, IL-13, interferon-alpha (IFN-α andbecause they are able to inhibit the release of pro inflammatorycytokines, to induce the production of IL-1 receptor antagonist (IL-raand the release of soluble TNF receptor and to limit some of the proinflammatory activities of IL-1 and TNF. However the events whichoccur during inflammation and sepsis are

  10. Propioceptores articulares y musculares

    OpenAIRE

    Vega, José A.

    1999-01-01

    La función de los mecanorreceptores de las articulaciones y músculos se considera asociada a la propiocepción. Sin embargo, existen evidencias de que la propiocepción no sólo depende del morfotipo de mecanorreceptor presente en dichos tejidos sino también de las propiedades de las neuronas sensitivas primarias y las fibras sensitivas asociadas a ellos, así como de su proyección sobre el asta posterior de la médula espinal. Este artículo resume las bases morfológicas de la propi...

  11. Postnatal development of articular cartilage

    NARCIS (Netherlands)

    Turnhout, van M.C.

    2010-01-01

    Articular cartilage (AC) is the thin layer of tissue that covers the ends of the bones in the synovial joints in mammals. Functional adult AC has depth-dependent mechanical properties that are not yet present at birth. These depth-dependent mechanical properties in adult life are the result of a dep

  12. Miopatía inflamatoria con compromiso inicial de músculos respiratorios y artritis reumatoidea

    Directory of Open Access Journals (Sweden)

    Martín Hunter

    2014-10-01

    Full Text Available Las miopatías inflamatorias constituyen un grupo heterogéneo de enfermedades musculares adquiridas de presentación subaguda, crónica y a veces aguda. Las entidades clínicas más frecuentes son la dermatomiositis, la polimiositis, la miositis necrotizante autoinmune y la miositis por cuerpos de inclusión. Suelen presentarse con debilidad muscular con predominio proximal y simétrica, pero rara vez comprometen los músculos respiratorios. Presentamos el caso de una mujer de 39 años con miopatía inflamatoria inespecífica que presentó insuficiencia respiratoria secundaria a hipoventilación alveolar por debilidad muscular y requirió asistencia respiratoria mecánica. Respondió favorablemente y de forma rápida tras el tratamiento instaurado con inmunosupresores (corticoides y metotrexato e inmunoglobulina humana endovenosa. Se utilizó ventilación no invasiva como alternativa a la intubación orotraqueal con adecuada tolerancia.

  13. Estudio de la dinámica embrionaria aplicando técnicas de registro de vibraciones. Correlación morfofuncional del desarrollo articular del embrión de pollo

    OpenAIRE

    Llusá Pérez, Manuel

    1986-01-01

    Utilizando un sensor de vibraciones (disco cerámico piezoeléctrico) y aparatos de medición y registro, se han estudiado las señales u ondas vibratorias producidas por los movimientos somáticos del embrión de pollo y su frecuencia cardiaca a lo largo de todo el periodo de desarrollo y bajo condiciones normales. Se obtuvieron datos dinámicos por tres vías diferentes que se complementan entre si: 1) Distribución temporal de los movimientos (periodos de actividad-inactividad de intensidad); 2) Di...

  14. Acil coenzima-a sintetasas de cadena larga (acsls) como biomarcadores citoserológicos en enfermedades inflamatorias o autoinmunes

    OpenAIRE

    Matesanz, F.; Fedetz, María; Ndagire, D.; Alcina, Antonio; Sabio, José Mario

    2010-01-01

    [ES] Uso de las Acil-Coenzima-A sintetasas de cadena larga (ACSL) como biomarcadores cito-serológicos de enfennedades inflamatorias o autoinmunes, y especialmente de lupus eritematoso sistémico, y método de obtención de datos útiles para el diagnóstico y seguimiento de dichas enfennedades.

  15. Dislipidemia del paciente críticamente enfermo

    OpenAIRE

    Raúl Carrillo-Esper; Roberto Carvajal-Ramos

    2005-01-01

    La dislipidemia del paciente críticamente enfermo es una entidadfrecuente y poco conocida. Los estados de choque, sepsis,respuesta inflamatoria sistémica de diversa etiología e isquemia-reperfusión se asocian a alteraciones en el metabolismo, com-posición y concentración de los lípidos plasmáticos, principal-mente colesterol, lipoproteínas de alta densidad y apolipoproteínaA-I, lo que resulta en incremento en el riesgo de infecciones,activación de la respuesta inflamatoria sistémica, disfunci...

  16. Luxación intra-articular de rótula Intra-articular dislocation of patella

    OpenAIRE

    2006-01-01

    Presentamos el caso de una paciente de 73 años de edad que, tras una caída accidental en las escaleras, sufrió una luxación intra-articular aguda de rótula de la rodilla izquierda. Esta luxación excepcional presentaba incarceración del polo proximal rotuliano en el surco intercondíleo femoral. Se realizó reducción bajo anestesia general debido al dolor y contractura muscular en los intentos de reducción sin anestesia. Realizamos revision quirúrgica que descartó lesiones asociadas del aparato ...

  17. FACTOR NUCLEAR κB (NF-κB: SIGNALOSOMA Y SU IMPORTANCIA EN ENFERMEDADES INFLAMATORIAS Y CÁNCER

    Directory of Open Access Journals (Sweden)

    Nancy P Echeverri R

    2008-06-01

    Full Text Available El factor nuclear κB (NF-κB es un dímero constituido por proteínas de la familia Rel. El NF-κB se encuentra en el citoplasma unido a proteínas inhibidoras (IkB. Las IkB son fosforiladas por diferentes cinasas que hacen parte del signalosoma como las cinasas de IKKα e IKKP y el modulador esencial de NF-κB (NEMO, la proteína cinasa activadora de mitosis (MAPK o p38 y la cinasa inductora de NF-κB (NIK. Estas cinasas al ser activadas por señales dependientes de citocinas y luz ultravioleta, fosforilan las IkB provocando su ubiquitinación, su degradación por proteosoma y la subsecuente liberación y translocación al núcleo de NF-κB. Recientemente se le ha dado una gran importancia al NF- k B en la vía de señalización desencadenada por estrés oxidativo, estrés genotóxico y daño en el DNA. A diferencia de la vía denominada clásica, en esta ruta ocurre una SUMOilación de NEMO y translocación al núcleo. En el núcleo NEMO interactúa con la proteína de la ataxia telangiectasia mutada (ATM activada en respuesta a modificaciones en la cromatina y daño en el DNA. El complejo ATM/NEMO es translocado al citoplasma donde la ATM fosforila a las IKK llevando a la ubiquitinación y posterior liberación de NF-κB que es translocado al núcleo. NF-κB desencadena procesos de supervivencia incluyendo el aumento de la transcripción de enzimas antioxidantes como la superóxido dismutasa, catalasa y glutatión. Estas enzimas participan en el control de los niveles de especies reactivas de oxígeno en la célula. La sobreactivación de NF-κB se relaciona con inflamación y cáncer. En la actualidad se desarrolla una búsqueda de fármacos que actúen sobre moléculas del signalosoma de NF-κB, no sólo para el manejo de enfermedades inflamatorias sino también para el uso durante el tratamiento de tumores resistentes a radio y quimioterapia.

  18. Classification of primary articular chondrocalcinosis.

    Science.gov (United States)

    Zitnan, D; Sitaj, S

    1979-01-01

    Based on long-term observations the authors submit a categorization of primary (hereditary and solitary) articular chondrocalcinosis into three different sub-populations. Attention is drawn to the fact that the extent of the qualitative disorder of the articular cartilage, obviously conditioned genetically, is linked with the age factor and determines the quantitative differences of pyrophosphate arthropathy in primary chondrocalcinosis. In young age, as a rule in the third decade, severe polyarticular condrocalcinosis (first sub-population) develops which causes relatively soon invalidity, in middle age (5th and 6th decade) milder condrocalcinosis develops (second sub-population) which combines with extraarticular, tendinous and tissue calcifacations, and finally in advanced age oligoarticular chondrocalcinosis develops (third sub-population) which is usually associated with ankylosing hyperostosis of the spine. Articular chondrocalcinosis (CCA) which we described by this term as a special metabolic arthropathy which occurs in families and solitary and which we defined as a special nosological unit (35, 36,) has become generally known and firmly established in rheumatology. As ensues from numerous publications, primary (idiopathic) CCA which comprises the hereditary and solitary (sporadic) form is characterized by pyrophosphate arthropathy which develops on articular cartilages not damaged by another process (13, 25, 26, 37); on the other hand as secondary CCA we consider pyrophosphate arthropathies which are associated with metabolic, endocrine or other diseases (9, 30). The common sign of both basic forms of CCA is the presence of microcrystals of calcium pyrophosphate dihydrate (CaPD) in articular cartilages, synovial fluid, or other articular structures (capsules, tendons, ligaments), characterized originally by McCarty et al. (11, 18) and later by other authors (2, 23, 27, 32). In addition to semantic (terminological) problems there were also questions of the

  19. Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes.

    Science.gov (United States)

    Rosenthal, Ann K; Gohr, Claudia M; Mitton-Fitzgerald, Elizabeth; Grewal, Rupinder; Ninomiya, James; Coyne, Carolyn B; Jackson, William T

    2015-05-22

    Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Factors affecting ACV formation and release remain poorly characterized; although in some cell types, the generation of extracellular vesicles is associated with up-regulation of autophagy. We sought to determine the role of autophagy in ACV production by primary articular chondrocytes. Using an innovative dynamic model with a light scatter nanoparticle counting apparatus, we determined the effects of autophagy modulators on ACV number and content in conditioned medium from normal adult porcine and human osteoarthritic chondrocytes. Healthy articular chondrocytes release ACVs into conditioned medium and show significant levels of ongoing autophagy. Rapamycin, which promotes autophagy, increased ACV numbers in a dose- and time-dependent manner associated with increased levels of autophagy markers and autophagosome formation. These effects were suppressed by pharmacologic autophagy inhibitors and short interfering RNA for ATG5. Caspase-3 inhibition and a Rho/ROCK inhibitor prevented rapamycin-induced increases in ACV number. Osteoarthritic chondrocytes, which are deficient in autophagy, did not increase ACV number in response to rapamycin. SMER28, which induces autophagy via an mTOR-independent mechanism, also increased ACV number. ACVs induced under all conditions had similar ecto-enzyme specific activities and types of RNA, and all ACVs contained LC3, an autophagosome-resident protein. These findings identify autophagy as a critical participant in ACV formation, and augment our understanding of ACVs in cartilage disease and repair.

  20. Tratamiento del paciente con artrosis

    OpenAIRE

    2014-01-01

    El manejo terapéutico del paciente con artrosis tiene como objetivo disminuir la sintomatología dolorosa e inflamatoria, mejorar la capacidad funcional del paciente y la aplicación de intervenciones terapéuticas eficaces y lo más seguras posibles. Un enfoque centrado en el paciente implica su participación activa en el diseño del plan terapéutico y en la toma de decisiones informadas oportunas en todas las etapas de la enfermedad. La educación terapéutica, la actividad física y el ejercicio t...

  1. Arthoscopy La artroscopia y las lesiones articulares

    Directory of Open Access Journals (Sweden)

    Raúl J. Naranjo

    1991-01-01

    Full Text Available

    A general view is presented on arthroscopy; its history, indications and limitations are described and analyzed; its advantages in comparison with open surgery are emphasized.

    La artroscopia es un procedimiento que permite, mediante un instrumento óptico, evaluar el Interior de las cavidades articulares. Comenzó a desarrollarse como un procedimiento diagnóstico y pronto sus grandes ventajas frente a las exploraciones abiertas aceleraron el desarrollo de las técnicas y del instrumental. La minimización del trauma a los tejidos y la menor morbilidad posoperatoria permiten que la deambulación y la recuperación funcional sean precoces lo cual, sumado a un mejor resultado estético, ha colocado a la artroscopia como procedimiento de elección para el diagnóstico y el tratamiento de múltiples estados patológicos intraarticulares.

  2. Tensorial electrokinetics in articular cartilage.

    Science.gov (United States)

    Reynaud, Boris; Quinn, Thomas M

    2006-09-15

    Electrokinetic phenomena contribute to biomechanical functions of articular cartilage and underlie promising methods for early detection of osteoarthritic lesions. Although some transport properties, such as hydraulic permeability, are known to become anisotropic with compression, the direction-dependence of cartilage electrokinetic properties remains unknown. Electroosmosis experiments were therefore performed on adult bovine articular cartilage samples, whereby fluid flows were driven by electric currents in directions parallel and perpendicular to the articular surface of statically compressed explants. Magnitudes of electrokinetic coefficients decreased slightly with compression (from approximately -7.5 microL/As in the range of 0-20% compression to -6.0 microL/As in the 35-50% range) consistent with predictions of microstructure-based models of cartilage material properties. However, no significant dependence on direction of the electrokinetic coupling coefficient was detected, even for conditions where the hydraulic permeability tensor is known to be anisotropic. This contrast may also be interpreted using microstructure-based models, and provides insights into structure-function relationships in cartilage extracellular matrix and physical mediators of cell responses to tissue compression. Findings support the use of relatively simple isotropic modeling approaches for electrokinetic phenomena in cartilage and related materials, and indicate that measurement of electrokinetic properties may provide particularly robust means for clinical evaluation of cartilage matrix integrity.

  3. La reacción inflamatoria en la fisiopatogenia de la obesidad

    Directory of Open Access Journals (Sweden)

    Ma. Victoria Domínguez García

    2012-01-01

    Full Text Available La obesidad se caracteriza por inflamación crónica. Entre los biomarcadores de inflamación encontramos las citocinas producidas por los adipocitos y los macrófagos: TNF - a, IL - 6, leptina, adiponectina y resistina. La relación adipocito-macrófago impacta la respuesta inflamatoria observada en la obesidad, la cual tiene una relación directa con la cantidad de macrófagos acumulados en el tejido adiposo blanco, que contribuye a la producción de mediadores de la inflamación. En este documento se hará una revisión de las principales moléculas involucradas en la generación de inflamación en la obesidad, y la relación entre macrófagos y adipocitos.

  4. Inestabilidad crónica de tobillo: tratamiento mediante movilizaciones articulares y un programa de entrenamiento propioceptivo. Validación de la versión española del cuestionario "Cumberland Ankle Instability Tool"

    OpenAIRE

    Cruz-Díaz, David

    2013-01-01

    [ES] La inestabilidad crónica de tobillo CAI es una patología muy frecuente debido a que hasta un 80% de todos los pacientes que sufren un esguince de tobillo desarrollan secuelas relacionadas con la inestabilidad mecánica y funcional. Basándonos en la fisioterapia basada en la evidencia, el tratamiento de esta patología mediante la aplicación de técnicas de movilización articular y entrenamiento propioceptivo parece ser el más acertado para mejorar los déficits funcionales de estos pacientes...

  5. Comparación de los efectos de dos técnicas de electroanalgesia en la enfermedad articular degenerativa tarsometatarsiana del equino Comparison between the effects of two electroanalgesical technics in the tarsometatarsal degenerative joint disease

    OpenAIRE

    2006-01-01

    Se realizó una experiencia para comparar los resultados analgésicos entre TENS (cuyas siglas derivan de la expresión en inglés: transcutaneus electrical neuromuscular stimulation) y el EMAR (estimulación mecánica por acción refleja) de efectividad comprobada en medicina equina, sobre un modelo clínico de 10 equinos afectados por enfermedad articular degenerativa tarsometatarsiana con un protocolo diagnóstico estandarizado. Sobre la misma población se hicieron los dos tratamientos con interval...

  6. Intra-articular chondroma of the knee

    Energy Technology Data Exchange (ETDEWEB)

    Talwalkar, S.C.; Kambhampati, S.B.S.; Lang Stevenson, A.I. [Oldchurch Hospital, Romford, Essex (United Kingdom); Whitehouse, R. [Manchester University, Department of Radiology, Manchester (United Kingdom); Freemont, A. [University of Manchester, Department of Osteoarticular Pathology, Manchester (United Kingdom)

    2005-06-01

    Chondromas are tumours that develop in relation to the periosteum and, although they are common around the knee, most reports deal with soft tissue chondromas in para-articular locations or intracortical tumours in extra-articular regions. We report a rare case of an intra-articular chondroma in a 16-year-old boy of Asian origin developing in the region of the medial femoral condyle of the femur and extending into the femoral sulcus and the patellofemoral joint. (orig.)

  7. Characterization of patient’s inflammatory pulpal diseases. Caracterización de pacientes con afecciones pulpares inflamatorias

    Directory of Open Access Journals (Sweden)

    Ana Isabel Palenque Guillemí

    2008-06-01

    Full Text Available Background: Pulpal diseases are the most common entities in the dentist emergency consultation. For a correct indication of the treatment, it is very important to establish an accurate diagnosis. Objective: to characterize carrier patients with inflammatory pulpal disease. Methods: a descriptive, prospective cases series study which included 222 patients who came to the dentistry emergency consultation in Area I health policlinic. Age, type of disease, cause, more implicated teeth in the disease, visits, and previous treatments were the variables included. Results: there was no difference at all regarding sex. The most affected group of age was from 35 to 59 years old. The inferior molars were the most affected teeth. The main cause was dental cavities. Obturation was the previous treatment more presented. 46% of the patients attended the dentist in more than one occasion with the same process. Acute irreversible pulpitis was the most predominant pulpal disease. Conclusions: The most common pulpal diseases in our milieu was the acute irreversible pulpitis among the ages 35 and 59 years old.
    Fundamento: Las afecciones pulpares son las enfermedades que más llevan a los pacientes a una consulta de urgencia estomatológica. En estos casos, para una correcta indicación de tratamiento, es de suma importancia el establecimiento de un diagnóstico preciso. Objetivo: Caracterizar pacientes portadores de afectaciones pulpares inflamatorias. Métodos: Estudio descriptivo, prospectivo de serie de casos que incluyó 222 pacientes que asistieron a consulta de urgencia estomatológica en la policlínica del Área 1. Se incluyeron las siguientes variables: edad, tipo de afectación, causa, dientes más afectados, visitas y tratamientos previos. Resultados: No hubo diferencias en cuanto al sexo, el

  8. Tratamiento farmacológico invasivo articular en la artrosis

    Directory of Open Access Journals (Sweden)

    D. Benítez Pareja

    2016-04-01

    Full Text Available La degeneración de las articulaciones axiales y periféricas va unida al propio envejecimiento del ser humano. Es responsable del dolor e impotencia funcional, y su fisiopatología es compleja y no del todo conocida. El denominador común en la artrosis es la degeneración del cartílago articular, junto a otras alteraciones secundarias. Su abordaje y manejo del dolor supone todo un reto para las Unidades del Dolor. Históricamente, el tratamiento intervencionista se llevó a cabo mediante infiltraciones a ciegas de diferentes sustancias que alivian el dolor. En la actualidad, la fluoroscopia, y más recientemente los ultrasonidos, son los métodos de elección para la guía de nuestros procedimientos. En cuanto a los fármacos utilizados más comúnmente en nuestras técnicas invasivas articulares destacaremos el ácido hialurónico (AH y el plasma rico en plaquetas (PRP. Los esteroides siguen siendo, en prácticamente todos los estudios, el estándar de oro o fármaco de referencia y sobre los que se comparan el resto de familias de fármacos. Una exploración exhaustiva del paciente, y un algoritmo de decisiones en cuanto a la decisión de realización de estas técnicas, se antoja necesario, adecuándose a cada lugar de trabajo.

  9. Tratamiento cognitivo-conductual protocolizado en grupo de las enfermedades inflamatorias intestinales Protocolized cognitive-behavioural group therapy for inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    M. A. Díaz Sibaja

    2007-10-01

    Full Text Available Introducción: los pacientes con enfermedades inflamatorias intestinales presentan una mayor tasa de alteraciones psicopatológicas que la población normal, predominantemente ansiedad y depresión. Objetivo: el principal objetivo de este estudio fue diseñar, poner en práctica y validar un programa de tratamiento psicológico protocolizado, basado en el modelo de competencias y con una metodología psicoeducativa, en el que se incluyeron los siguientes módulos de intervención: información de la enfermedad, modelo de afrontamiento, solución de problemas, técnicas de relajación, entrenamiento en habilidades sociales, técnicas de distracción y técnicas de reestructuración cognitiva. Todas estás técnicas fueron adaptadas a la problemática característica de la enfermedad inflamatoria intestinal. Método: la muestra estuvo constituida por 57 pacientes diagnosticados de enfermedad inflamatoria intestinal de la Asociación de Enfermos de Crohn y Colitis Ulcerosa de España. La muestra se distribuyó aleatoriamente en dos grupos experimentales, 33 formaron parte del programa de tratamiento en grupo y 24 fueron asignados al grupo control en lista de espera. Las variables emocionales medidas fueron: ansiedad y depresión. Resultados: los resultados reflejaron una mejoría clínica y estadísticamente significativa en las variables de ansiedad (p Introduction: patients affected by inflammatory bowel disease have a high rate of psychiatric disorders such as depression and anxiety. Objective: the main goal of this study was to design, to put into practice, and to validate a protocolized psychological treatment program based on the coping model, and a psycho-educational methodology in which the following intervention modules were included- illness information, coping model, problem solving techniques, relaxation, social skill training, distraction, and cognitive restructuring techniques. All these techniques were adapted to the characteristic

  10. Importancia de los lípidos en el tratamiento nutricional de las patologías de base inflamatoria Importance of lipids in the nutritional treatment of inflammatory diseases

    Directory of Open Access Journals (Sweden)

    M. D. Mesa García

    2006-05-01

    Full Text Available En las últimas décadas, el conocimiento acerca de las propiedades antiinflamatorias de los lípidos ha facilitado el desarrollo de productos adaptados a la nutrición enteral y parenteral que han sido utilizados como terapia en numerosas enfermedades de base inflamatoria. En esta revisión se ofrece una visión general de los efectos de los lípidos utilizados en nutrición enteral, sobre ciertas patologías en cuya base están implicados procesos inflamatorios, como es el caso de las enfermedades inflamatorias intestinales, la aterosclerosis, la fibrosis pulmonar y la artritis reumatoide, entre otras. Durante los procesos inflamatorios se producen mediadores químicos, como los eicosanoides, a partir de ácidos grasos poliinsaturados presentes en las membranas celulares. La actividad inflamatoria de estas moléculas depende del ácido graso precursor. Los derivados del ácido araquidónico (de la serie n-6 tienen una elevada actividad proinflamatoria, mientras que los derivados del eicosapentaenoico (de la serie n-3 son débilmente inflamatorios. Así, al ingerir aceites de pescado, ricos en ácidos grasos n-3, aumenta el contenido de eicosapentaenoico y disminuye el araquidónico en las células del sistema inmune, por lo que se reduce la estimulación inflamatoria debido a la presencia de mediadores menos activos. Éste parece ser el mecanismo inmunomodulador fundamental de las dietas ricas en n-3. Asimismo, pero mediante mecanismos de acción diferentes, se ha demostrado que el ácido oleico disminuye la intensidad de algunos procesos inflamatorios, al disminuir la producción de mediadores quimiotácticos de inflamación. Podemos concluir que la suplementación de dietas para nutrición enteral con ácidos grasos poliinsaturados n-3 y oleico resulta beneficiosa para el tratamiento de ciertas patologías donde los procesos inflamatorios participan activamente en su desarrollo, mejorando su evolución y disminuyendo las dosis de f

  11. Evaluación del riesgo cardiovascular en pacientes con espondiloartritis predominantemente axial

    OpenAIRE

    Rueda Gotor, Javier

    2016-01-01

    RESUMEN: La presente tesis confirma la existencia en la espondilitis anquilosante (EA) de un proceso de aterogénesis acelerada equiparable al de otras enfermedades inflamatorias crónicas. Dicho proceso no fue observado sin embargo en la espondiloartritis axial no radiológica, probablemente por su inferior respuesta inflamatoria. Estos hallazgos fueron objetivados mediante 2 trabajos a través del estudio ultrasonográfico de placas carotideas y espesor íntima-media carotídea tanto en pacientes ...

  12. Efecto de las cargas articulares sobre el flujo y pH salival

    OpenAIRE

    Castro,RJ; Bravo, C; Alcaino,V; Giacaman,RA

    2011-01-01

    Una alteración del flujo salival es clave en el desarrollo de caries, enfermedad periodontal e infecciones oportunistas. El flujo salival está determinado por diversos estímulos que actúan sobre receptores de distinta naturaleza, entre ellos mecanoreceptores articulares. Algunos estudios demuestran que las cargas articulares actúan sobre estos receptores, modificando cualitativa y cuantitativamente la secreción salival. El objetivo de este estudio fue determinar si existe una relación entre l...

  13. Estabilidade articular: abordagem biomecânica

    OpenAIRE

    Alex Sandra Oliveira de Cerqueira Soares

    2015-01-01

    A instabilidade articular é responsável pelo desenvolvimento de lesões degenerativas incapacitantes que comprometem o desempenho funcional. Compreender os processos desenvolvidos para estabilização dinâmica articular é um desafio para pesquisadores das mais diversas áreas. O presente estudo propõe o uso da abordagem Biomecânica para reconhecer os mecanismos relacionadas ao processo de estabilização dinâmica articular, por meio de três diferentes condições experimentais. No experimento 1 foi a...

  14. Imaging of intra-articular osteoid osteoma

    Energy Technology Data Exchange (ETDEWEB)

    Allen, S.D.; Saifuddin, A. E-mail: asaifuddin@aol.com

    2003-11-01

    Intra-articular osteoid osteoma accounts for approximately 13% of all osteoid osteomas and presents as a monoarthropathy. Radiographs commonly do not identify the nidus, and in this event, MRI is likely to be the next imaging investigation. MRI may show a variety of appearances depending upon the age of the lesion. This article illustrates the imaging features of intra-articular osteoid osteoma, with emphasis on MRI. CT remains the investigation of choice for identifying the nidus.

  15. Human stem cells and articular cartilage regeneration.

    Science.gov (United States)

    Inui, Atsuyuki; Iwakura, Takashi; Reddi, A Hari

    2012-11-05

    The regeneration of articular cartilage damaged due to trauma and posttraumatic osteoarthritis is an unmet medical need. Current approaches to regeneration and tissue engineering of articular cartilage include the use of chondrocytes, stem cells, scaffolds and signals, including morphogens and growth factors. Stem cells, as a source of cells for articular cartilage regeneration, are a critical factor for articular cartilage regeneration. This is because articular cartilage tissue has a low cell turnover and does not heal spontaneously. Adult stem cells have been isolated from various tissues, such as bone marrow, adipose, synovial tissue, muscle and periosteum. Signals of the transforming growth factor beta superfamily play critical roles in chondrogenesis. However, adult stem cells derived from various tissues tend to differ in their chondrogenic potential. Pluripotent stem cells have unlimited proliferative capacity compared to adult stem cells. Chondrogenesis from embryonic stem (ES) cells has been studied for more than a decade. However, establishment of ES cells requires embryos and leads to ethical issues for clinical applications. Induced pluripotent stem (iPS) cells are generated by cellular reprogramming of adult cells by transcription factors. Although iPS cells have chondrogenic potential, optimization, generation and differentiation toward articular chondrocytes are currently under intense investigation.

  16. Human Stem Cells and Articular Cartilage Regeneration

    Directory of Open Access Journals (Sweden)

    A. Hari Reddi

    2012-11-01

    Full Text Available  The regeneration of articular cartilage damaged due to trauma and posttraumatic osteoarthritis is an unmet medical need. Current approaches to regeneration and tissue engineering of articular cartilage include the use of chondrocytes, stem cells, scaffolds and signals, including morphogens and growth factors. Stem cells, as a source of cells for articular cartilage regeneration, are a critical factor for articular cartilage regeneration. This is because articular cartilage tissue has a low cell turnover and does not heal spontaneously. Adult stem cells have been isolated from various tissues, such as bone marrow, adipose, synovial tissue, muscle and periosteum. Signals of the transforming growth factor beta superfamily play critical roles in chondrogenesis. However, adult stem cells derived from various tissues tend to differ in their chondrogenic potential. Pluripotent stem cells have unlimited proliferative capacity compared to adult stem cells. Chondrogenesis from embryonic stem (ES cells has been studied for more than a decade. However, establishment of ES cells requires embryos and leads to ethical issues for clinical applications. Induced pluripotent stem (iPS cells are generated by cellular reprogramming of adult cells by transcription factors. Although iPS cells have chondrogenic potential, optimization, generation and differentiation toward articular chondrocytes are currently under intense investigation.

  17. La modulación de sentencias como medio para articular la oportunidad política de la Corte Constitucional colombiana. El caso de las parejas del mismo sexo

    Directory of Open Access Journals (Sweden)

    Juan Pablo Sarmiento E.

    2012-01-01

    Full Text Available En el marco de la trasformación que ha sufrido el régimen de derecho de familia hacia la inclusión de parejas del mismo sexo, la Corte Constitucional ha jugado un papel central y quizá solitario. En este artículo se analizan los principales fallos de la Corte Constitucional relativos a la unificación en el ámbito de protección a las parejas del mismo sexo, extrayendo de cada uno de ellos los elementos de creación jurisprudencial más relevantes. Con lo anterior se argumentará, entonces, que por medio de diversos instrumentos interpretativos, la Corte ha instrumentalizado sus fallos para ejercer su oportunidad política en dirección a la opinión prevalente por medio del condicionamiento de las sentencias de constitucionalidad.

  18. Impacto de la fatiga en la percepción de salud en la enfermedad inflamatoria intestinal.

    OpenAIRE

    Castillo Cejas, María Dolores

    2011-01-01

    La salud de los pacientes con enfermedad inflamatoria intestinal (EII) está afectada por la fatiga, que condiciona una baja calidad de vida. Este estudio administró cuestionarios de calidad de vida y fatiga a 110 pacientes con EII, cuantificando fatiga y correlacionándola con la actividad, se determinó la afectación de la calidad de vida. Los resultados mostraron relación inversa entre fatiga y actividad de EII, con diferencias estadísticamente significativas según brote o remisión de la enfe...

  19. Análisis y aplicación de estrategias para modular la respuesta inflamatoria en patologías intestinales

    OpenAIRE

    Orsini Delgado, María Lucía

    2016-01-01

    Durante las últimas décadas se ha reportado un importante incremento en la incidencia de patologías inmunes inflamatorias, no infecciosas, fundamentalmente en países desarrollados o en vías de desarrollo. Debido a la velocidad con que se ha incrementado la incidencia de estas patologías, sólo los cambios en los factores ambientales son capaces de explicarlo. Estudios epidemiológicos han permitido observar una asociación entre el incremento en patologías inflamatorias no infecciosas y la dismi...

  20. Articular chondrocyte metabolism and osteoarthritis

    Energy Technology Data Exchange (ETDEWEB)

    Leipold, H.R.

    1989-01-01

    The three main objectives of this study were: (1) to determine if depletion of proteoglycans from the cartilage matrix that occurs during osteoarthritis causes a measurable increase of cartilage proteoglycan components in the synovial fluid and sera, (2) to observe what effect intracellular cAMP has on the expression of matrix components by chondrocytes, and (3) to determine if freshly isolated chondrocytes contain detectable levels of mRNA for fibronectin. Canine serum keratan sulfate and hyaluronate were measured to determine if there was an elevation of these serum glycosaminoglycans in a canine model of osteoarthritis. A single intra-articular injection of chymopapain into a shoulder joint increased serum keratan sulfate 10 fold and hyaluronate less than 2 fold in 24 hours. Keratan sulfate concentrations in synovial fluids of dogs about one year old were unrelated to the presence of spontaneous cartilage degeneration in the joints. High keratan sulfate in synovial fluids correlated with higher keratan sulfate in serum. The mean keratan sulfate concentration in sera of older dogs with osteoarthritis was 37% higher than disease-free controls, but the difference between the groups was not statistically significant. Treatment of chondrocytes with 0.5 millimolar (mM) dibutyryl cAMP (DBcAMP) caused the cells to adopt a more rounded morphology. There was no difference between the amount of proteins synthesized by cultures treated with DBcAMP and controls. The amount of fibronectin (FN) in the media of DBcAMP treated cultures detected by an ELISA was specifically reduced, and the amount of {sup 35}S-FN purified by gelatin affinity chromatography decreased. Moreover, the percentage of FN containing the extra domain. A sequence was reduced. Concomitant with the decrease in FN there was an increase in the concentration of keratan sulfate.

  1. Asma bronquial. Estado del arte.

    OpenAIRE

    Jorge Salazar

    2009-01-01

    Para infinidad de personas el asma es su problema de salud. El diagnóstico y el tratamiento varían dependiendo de la magnitud del compromiso y la causa que produce la reacción inflamatoria en los pulmones. La prevención y el tratamiento serán mejores si la población y los pacientes reconocen la necesidad de evitar determinadas exposiciones ambientales y el uso de medicamentos con la frecuencia necesaria. Ahora los médicos generales conocen mejor la fisiología y patología de esta enfermedad y ...

  2. Imaging of the cervical articular pillar

    Energy Technology Data Exchange (ETDEWEB)

    Yeomans, E. [Orange Base Hospital, Orange, NSW (Australia)

    1998-12-01

    The cervical articular pillar, due to the complex anatomical structure of the cervical spine, is not well demonstrated in routine plain radiographic views. Dedicated views have been devised to demonstrate the pillar, yet their performance has abated considerably since the inception of Computed Tomography (CT) in the 1970`s. It is the consideration that CT does not image the articular pillar with a 10 per cent accuracy that poses the question: Is there still a need for plain radiography of the cervical articular pillar? This paper studies the anatomy, plain radiography, and incidence of injury to the cervical articular pillar. It discusses (with reference to current and historic literature) the efficacy of current imaging protocols in depicting this injury. It deals with plain radiography, CT, complex tomography, and Magnetic Resonance Imaging (MRI) of the cervical spine to conclude there may still be a position in current imaging protocols for plain radiography of the cervical articular pillar. Copyright (1998) Australian Institute of Radiography 43 refs., 5 figs.

  3. Enfermedad inflamatoria intestinal en pacientes celíacos Inflammatory bowel disease in celiac patients

    Directory of Open Access Journals (Sweden)

    M. Masachs

    2007-08-01

    Full Text Available Introducción: se ha sugerido una potencial asociación entre la enfermedad celíaca y la enfermedad inflamatoria intestinal, que puede justificar que ambas enfermedades puedan presentarse en un mismo enfermo o en sus familiares de primer orden con mayor frecuencia de lo esperado. Objetivo: determinar la prevalencia de la enfermedad de Crohn y la colitis ulcerosa en los enfermos celíacos y en sus familiares. Método: estudio epidemiológico prospectivo transversal en un grupo de pacientes celíacos, sus familiares de primer grado y un grupo control de características epidemiológicas similares, constituido por familiares de pacientes que acuden al Servicio de Urgencias por un problema agudo. Para detectar la existencia de colitis ulcerosa y enfermedad de Crohn en los celíacos y sus familiares, se realizó una entrevista semiestructurada. Resultados: se han incluido 86 celíacos y 432 familiares, que se han comparado con 809 controles (129 pacientes con una enfermedad aguda y 680 familiares de primer grado suyos. Se han detectado 3 casos de enfermedad de Crohn en el grupo de los enfermos celíacos y 4 casos de enfermedad de Crohn en sus familiares. Sólo se ha detectado 1 caso de enfermedad de Crohn en el grupo control (p Introduction: a potential association between celic disease and inflammatory bowel disease hs been suggested, which may explain the fact that both disorders occasionally present in one patient or in his/her first-degree relatives more frequently than expected. Objective: to establish the prevalence of Crohn's disease and ulcerative colitis in celiac patients and their relatives. Method: a cross-sectional, prospective epidemiological study in a group of celiac patients, their first-degree relatives, and a control group with similar epidemiological characteristics including the relatives of patients presenting at the ER for acute conditions. A semistructured interview was used to identify the presence of Crohn's disease and

  4. Estudio PET/TC en patología inflamatoria-infecciosa PET/CT in infectious and inflammatory pathology

    Directory of Open Access Journals (Sweden)

    Cecilia Carrera

    2012-06-01

    Full Text Available Objetivo. Demostrar la utilidad del examen PET/TC en patología inflamatoria-infecciosa. Materiales y Métodos. Evaluación retrospectiva (enero de 2009 - mayo de 2011 de los exámenes de tomografía por Emisión de Positrones/ Tomografía Computada (PET/TC, realizados en nuestra institución con un equipo híbrido SIEMENS-BIOGRAPH 16 (Siemens, Erlangen, Alemania. Se seleccionaron 5 pacientes. Resultados. Caso 1: paciente de 68 años de edad con fiebre de 6 meses de duración, fatiga y pérdida de peso. El examen reumatológico demostró disminución en pulsos radiales sin otros síntomas asociados. La paciente fue sometida a biopsia de arteria temporal. Ésta confirmó una arteritis de la arteria temporal y el estudio PET/TC demostró hipermetabolismo en la aorta torácica y ramas principales. Caso 2: paciente de 85 años con fiebre de origen desconocido (FOD y sospecha de osteomielitis de cadera. En contraposición, el PET/TC demostró un foco ávido de celulitis glútea y neumopatía. Caso 3: paciente de 35 años con fiebre vespertina. El PET/TC mostró múltiples adenomegalias ávidas por fluorodexosiglucosa (FDG en mediastino, axilas y retroperitoneo, y compromiso difuso esplénico asociado a calcificaciones. Se confirmó infección por citomegalovirus por inmuno-globulina G y M. Caso 4: paciente de 39 años con infección por HIV que consultó por hipercalcemia. El PET/TC mostró implantes de silicona en glúteos con proceso inflamatorio ávido asociado. Se confirmó por la biopsia de uno de ellos. Caso 5: paciente de 45 años con historia de cáncer de mama en control presentó en los últimos estudios tomográficos aumento del tamaño de los ganglios supraclaviculares y mediastínicos, y compromiso esplénico multifocal difuso. Estos resultaron ávidos en el examen PET/TC. Se confirmó el diagnóstico de sarcoidosis por el estudio anatomopatológico de un ganglio supraclavicular. Conclusiones. El PET/TC es un método no invasivo de

  5. Development of artificial articular cartilage

    Indian Academy of Sciences (India)

    Biswajit Bera

    2009-10-01

    The present study describes the development of artificial articular cartilage on the basis of mimicking structural gel properties and mechanical gel properties of natural articular cartilage. It is synthesized from PVA/Si nanocomposite containing 20% Tetra ethoxy silane (TEOS) by sol–gel method. Mechanical strength of Poly(vinyl alcohol), PVA is improved up to 35 MPa. Manufacturing method is adopted considering colloidal stability of nano silica particle in PVA sol at specific pH = 1. An adhesive is also prepared from PVA/Si nanocomposite containing 40% TEOS for firm attachment of artificial articular cartilage on underlying bone with high bond strength.

  6. Acil Coenzima-A sintetasas de cadena larga (ACSLs) como biomarcadores cito-serológicos en enfermedades inflamatorias o autoinmunes

    OpenAIRE

    Matesanz, F.; Fedetz, María; Ndagire, D.; Alcina, Antonio; Sabio, José Mario

    2010-01-01

    Uso de las Acil-Coenzima-A sintetasas de cadena larga (ACSL) como biomarcadores cito-serológicos de enfermedades inflamatorias o autoinmunes, y especialmente de lupus eritematoso sistémico, y método de obtención de datos útiles para el diagnóstico y seguimiento de dichas enfermedades. Venta

  7. Intra-articular angiolipoma of the knee: a case report

    Directory of Open Access Journals (Sweden)

    Nishimori Makoto

    2010-04-01

    Full Text Available Abstract We report a case of intra-articular angiolipoma of the knee. This case report describes our experience in excising an intra-articular angiolipoma of the knee joint. Complete resection under arthroscopy was performed in a 30-year-old man. Two years after the surgery, no evidence of recurrence was seen. Intra-articular angiolipomas should be considered in the differential diagnosis of intra-articular masses in adolescents with recurrent hemarthrosis without trauma.

  8. Comportamiento de variables epidemiológicas en la neuropatía óptica inflamatoria infecciosa. Centro Oftalmológico de Holguín. 2009

    Directory of Open Access Journals (Sweden)

    Enma Estrella de la Torre-Rodríguez

    2012-01-01

    Full Text Available Abordó un estudio descriptivo del comportamiento de algunas variables epidemiológicas en un universo de 18 pacientes con neuropatía óptica inflamatoria en el Centro Oftalmológico de Holguín de enero a diciembre de 2009. La muestra estuvo representada por 12 pacientes con etiología infecciosa. El mayor número de pacientes se incluyó en el grupo de edad de 15 a 29 años. Las ocupaciones de riesgo más frecuentes fueron los estudiantes, las amas de casa y criadores de palomas. Los perros, gatos y cerdos fueron los animales más frecuentes en contacto con los casos. La etiología parasitaria representó el grupo más frecuente como causa de la neuropatía y el agente que predominó fue Bartonella henselae. Se recomendó realizar estudios que incluyan confirmación serológica y/o del agente causal en este grupo de enfermedades.

  9. Preparation of Articular Cartilage Specimens for Scanning Electron Microscopy.

    Science.gov (United States)

    Stupina, T A

    2016-08-01

    We developed and adapted a technology for preparation of articular cartilage specimens for scanning electron microscopy. The method includes prefixation processing, fixation, washing, and dehydration of articular cartilage specimens with subsequent treatment in camphene and air-drying. The technological result consists in prevention of deformation of the articular cartilage structures. The method is simpler and cheaper than the known technologies.

  10. Luxación intra-articular de rótula Intra-articular dislocation of patella

    Directory of Open Access Journals (Sweden)

    S. García-Mata

    2006-08-01

    Full Text Available Presentamos el caso de una paciente de 73 años de edad que, tras una caída accidental en las escaleras, sufrió una luxación intra-articular aguda de rótula de la rodilla izquierda. Esta luxación excepcional presentaba incarceración del polo proximal rotuliano en el surco intercondíleo femoral. Se realizó reducción bajo anestesia general debido al dolor y contractura muscular en los intentos de reducción sin anestesia. Realizamos revision quirúrgica que descartó lesiones asociadas del aparato extensor, partes blandas, estructuras articulares y osteofitos. Presentaba artrosis avanzada, sobre todo fémoro-patelar. Tras dos semanas de inmovilización reinició movilidad. No ha presentado recidiva u otro tipo de complicaciones.The case of a patient aged 73 years who, following an accidental fall on a staircase, suffered an acute intraarticular dislocation in the left knee-cap is presented. This exceptional dislocation presented incarceration of the proximal kneecap pole in the femoral intercondylar groove. A reduction was carried out under general anaesthetic due to pain and muscular contraction in the attempts at reduction without anaesthetic. We made a surgical check that ruled out associated lesions to the extensor apparatus, soft parts, joint structures and osteophytes. The patient presented advanced arthrosis, above all femoral-patellar. Following two weeks of immobilisation, the patient restarted mobility. There has been no relapse or other type of complication.

  11. Determinación de citoquinas en espondiloartropatías inflamatorias: valoración de la actividad clínico-biológica en la artropatía psoriásica

    OpenAIRE

    Turrión Nieves, Ana Isabel

    2015-01-01

    Las espondiloartritis o espondiloartropatías inflamatorias constituyen un grupo de enfermedades reumáticas inflamatorias que afectan fundamentalmente a la columna vertebral. De estas la espondilitis anquilosante (EAnq) y la artropatía psoriásica (Aps), son las afectaciones más frecuentes. Los niveles de citoquinas y/o reactantes de fase aguda son marcadores biológicos de actividad clínica inflamatoria. Por ello siendo estas moléculas cuantificables en el laboratorio, su determinación puntual ...

  12. Advanced Strategies for Articular Cartilage Defect Repair

    Directory of Open Access Journals (Sweden)

    Fergal J. O'Brien

    2013-02-01

    Full Text Available Articular cartilage is a unique tissue owing to its ability to withstand repetitive compressive stress throughout an individual’s lifetime. However, its major limitation is the inability to heal even the most minor injuries. There still remains an inherent lack of strategies that stimulate hyaline-like articular cartilage growth with appropriate functional properties. Recent scientific advances in tissue engineering have made significant steps towards development of constructs for articular cartilage repair. In particular, research has shown the potential of biomaterial physico-chemical properties significantly influencing the proliferation, differentiation and matrix deposition by progenitor cells. Accordingly, this highlights the potential of using such properties to direct the lineage towards which such cells follow. Moreover, the use of soluble growth factors to enhance the bioactivity and regenerative capacity of biomaterials has recently been adopted by researchers in the field of tissue engineering. In addition, gene therapy is a growing area that has found noteworthy use in tissue engineering partly due to the potential to overcome some drawbacks associated with current growth factor delivery systems. In this context, such advanced strategies in biomaterial science, cell-based and growth factor-based therapies that have been employed in the restoration and repair of damaged articular cartilage will be the focus of this review article.

  13. Body weight independently affects articular cartilage catabolism.

    Science.gov (United States)

    Denning, W Matt; Winward, Jason G; Pardo, Michael Becker; Hopkins, J Ty; Seeley, Matthew K

    2015-06-01

    Although obesity is associated with osteoarthritis, it is unclear whether body weight (BW) independently affects articular cartilage catabolism (i.e., independent from physiological factors that also accompany obesity). The primary purpose of this study was to evaluate the independent effect of BW on articular cartilage catabolism associated with walking. A secondary purpose was to determine how decreased BW influenced cardiovascular response due to walking. Twelve able-bodied subjects walked for 30 minutes on a lower-body positive pressure treadmill during three sessions: control (unadjusted BW), +40%BW, and -40%BW. Serum cartilage oligomeric matrix protein (COMP) was measured immediately before (baseline) and after, and 15 and 30 minutes after the walk. Heart rate (HR) and rate of perceived exertion (RPE) were measured every three minutes during the walk. Relative to baseline, average serum COMP concentration was 13% and 5% greater immediately after and 15 minutes after the walk. Immediately after the walk, serum COMP concentration was 14% greater for the +40%BW session than for the -40%BW session. HR and RPE were greater for the +40%BW session than for the other two sessions, but did not differ between the control and -40%BW sessions. BW independently influences acute articular cartilage catabolism and cardiovascular response due to walking: as BW increases, so does acute articular cartilage catabolism and cardiovascular response. These results indicate that lower-body positive pressure walking may benefit certain individuals by reducing acute articular cartilage catabolism, due to walking, while maintaining cardiovascular response. Key pointsWalking for 30 minutes with adjustments in body weight (normal body weight, +40% and -40% body weight) significantly influences articular cartilage catabolism, measured via serum COMP concentration.Compared to baseline levels, walking with +40% body weight and normal body weight both elicited significant increases in

  14. Selenio en los pacientes críticos con Respuesta Inflamatoria Sistémica Selenium in critically ill patients with systemic inflammatory response

    Directory of Open Access Journals (Sweden)

    W. Manzanares Castro

    2007-06-01

    Full Text Available El Selenio es un micronutriente esencial para el hombre. Los estados de Respuesta Inflamatoria Sistémica (RIS y Disfunción Orgánica Múltiple (DOM tales como la sepsis severa, el trauma grave, la pancreatitis severa y quemaduras críticas se caracterizan por la existencia de estrés oxidativo. En este contexto, la depleción del estado nutricional de Selenio es una característica distintiva; la misma se traduce por una reducción de los niveles séricos de Selenio y de las diferentes selenoenzimas, en especial la Glutatión Peroxidasa y la Selenoproteína P. Estas selenoproteínas antioxidantes cumplen un rol protectivo frente a la lipoperoxidación de las membranas celulares participando además en el proceso de regulación de la respuesta inflamatoria. Ha sido demostrada la existencia de una correlación directa entre el grado de depleción de Selenio y la severidad de la enfermedad crítica. En los últimos años, numerosos estudios clínicos han investigado los efectos de la suplementación de Selenio en pacientes críticos con RIS -DOM. Esta estrategia terapéutica sería capaz de mejorar los resultados optimizando el pronóstico de la enfermedad crítica. En tal sentido, algunos pequeños estudios clínicos han demostrado una disminución del número de complicaciones infecciosas y de la estadía hospitalaria en los grupos de pacientes críticos suplementados con Selenio. Sin embargo, hasta el momento actual no existen datos concluyentes que permitan definitivamente afirmar la existencia de una reducción significativa de la mortalidad con el uso de Selenio en Terapia Intensiva. El objetivo del presente artículo de revisión es estudiar el metabolismo y estado nutricional del Selenio, evaluar el rol de las selenoenzimas durante la enfermedad crítica y repasar los estudios de suplementación de Selenio como estrategia antioxidante en Terapia Intensiva analizando por último la evidencia actual. Las recomendaciones actuales parecen

  15. Pharmacological Nutrition in Inflammatory Bowel Diseases Nutrición farmacológica en las enfermedades inflamatorias del instestino

    OpenAIRE

    F. G. Campos; D. L. Waitzberg; Teixeira,M. G.; D. R. Mucerino; D. R. Kiss; Habr-Gama, A.

    2003-01-01

    Inflammatory Bowel Diseases - ulcerative colitis and Crohn’s disease- are chronic gastrointestinal inflammatory diseases of unknown etiology. Decreased oral intake, malabsorption, accelerated nutrient losses, increased requirements, and drug-nutrient interactions cause nutritional and functional deficiencies that require proper correction by nutritional therapy. The goals of the different forms of nutritional therapy are to correct nutritional disturbances and to modulate inflammatory respons...

  16. Calidad de vida relacionada con la salud en pacientes con enfermedad inflamatoria intestinal

    Directory of Open Access Journals (Sweden)

    R. López Cortés

    Full Text Available Fundamento. Determinar la calidad de vida relacionada con la salud en pacientes con enfermedad de Crohn y colitis ulcerosa, así como evaluar las diferencias en función del sexo, tipo de enfermedad y otras variables sociodemográficas. Método. Estudio observacional, descriptivo y transversal en 100 pacientes atendidos en el servicio de Digestivo del Complejo Hospitalario de Navarra. Se empleó un cuestionario con variables sociodemográficas y clínicas, además del Inflammatory Bowel Disease Questionnaire-32, en su versión adaptada al castellano, para medir la calidad de vida. Resultados. La media de la puntuación total del cuestionario de calidad vida es de 166 puntos (D.T.=40,06 sobre un máximo de 232. Se han hallado diferencias estadísticamente significativas en función del tipo de enfermedad (p=0,005 y el sexo (p=0,001. Conclusiones. Las personas con enfermedad de Crohn o sexo femenino perciben peor calidad de vida relacionada con la salud respecto a pacientes con colitis ulcerosa u hombres.

  17. Avaliação do impacto da aplicação de manobra de hiperinsuflação pulmonar sobre a resposta inflamatória sistêmica e colapso pulmonar em pacientes submetidos a procedimentos cirúrgicos sob ventilação espontânea Evaluación del impacto de la aplicación de maniobra de hiperinsuflación pulmonar sobre la respuesta inflamatoria sistémica y colapso pulmonar en pacientes sometidos a procedimientos quirúrgicos bajo ventilación espontánea Assessing the impact of lung hyperinflation maneuver on systemic inflammatory response and lung collapse in patients undergoing surgeries under spontaneous ventilation

    Directory of Open Access Journals (Sweden)

    Luiz Marcelo Sá Malbouisson

    2010-06-01

    puede conllevar a una respuesta inflamatoria sistémica de origen pulmonar. Los objetivos de este estudio fueron comprobar el impacto de la aplicación de MHP sobre la respuesta inflamatoria sistémica y sobre la estructura pulmonar en pacientes sometidos a la anestesia subaracnoidea. MÉTODO: Después de la aprobación del Comité de Ética institucional y de la obtención del consentimiento informado, 20 pacientes sometidos a procedimientos quirúrgicos de pequeño y mediano porte, se separaron aleatoriamente en dos grupos: 1 control (GC y 2 MHP (GMHP. Una hora después de la instalación del bloqueo espinal, fue realizada MHP en el GMHP aplicando una presión positiva en las vías aéreas en los niveles (BIPAP con una presión espiratoria de 20 cmH2O y una presión inspiratoria de 20 cmH2O durante 1 a 2 minutos. FNTα, IL-1, IL-6, IL-8, IL-10 y IL-12 se midieron en la sangre a través de la técnica de citometría de flujo en los momentos basal, 90, 180 y 780 minutos. Los volúmenes y el peso pulmonares fueron computados a partir de tomografías computadorizadas obtenidas inmediatamente después de la operación. RESULTADOS: La aplicación de MHP resultó en una reducción de la fracción del parénquima pulmonar no aerado (7,5 ± 4,3% en el Grupo Control vs 4 ± 2,1% en el Grupo MHP, p = 0,02, sin alteraciones en los volúmenes pulmonares. Se observó una elevación progresiva en los valores plasmáticos de las interleucinas IL-1, IL-6, IL-8 y IL-10, similar en los dos grupos. Los niveles plasmáticos de FNTBACKGROUND AND OBJECTIVES: Lung hyperinflation maneuvers (LHM reverse intraoperative atelectasis; however, they can lead to pulmonary-induced systemic inflammatory response. The objective of this study was to determine the impact of LHM on systemic inflammatory response and lung structure in patients undergoing subarachnoid block. METHODS: After approval by the Ethics Committee of the institution and signing the informed consent, 20 patients undergoing small and

  18. The minor collagens in articular cartilage

    DEFF Research Database (Denmark)

    Luo, Yunyun

    2017-01-01

    Articular cartilage is a connective tissue consisting of a specialized extracellular matrix (ECM) that dominates the bulk of its wet and dry weight. Type II collagen and aggrecan are the main ECM proteins in cartilage. However, little attention has been paid to less abundant molecular components......, especially minor collagens, including type IV, VI, IX, X, XI, XII, XIII, and XIV, etc. Although accounting for only a small fraction of the mature matrix, these minor collagens not only play essential structural roles in the mechanical properties, organization, and shape of articular cartilage, but also...... fulfil specific biological functions. Genetic studies of these minor collagens have revealed that they are associated with multiple connective tissue diseases, especially degenerative joint disease. The progressive destruction of cartilage involves the degradation of matrix constituents including...

  19. Pure waterjet drilling of articular bone

    OpenAIRE

    Biskup, Christian; Dunnen, Steven den; Kraaij, Gert; Kerkhoffs, Gino M. M. J.; Tuijthof, Gabrielle J. M.

    2015-01-01

    The clinical application of waterjet technology for machining tough human tissues, such as articular bone, has advantages, as it produces clean sharp cuts without tissue heating. Additionally, water supply is possible via flexible tubing, which enables minimally invasive surgical access. This pilot study investigates whether drilling bony tissue with pure waterjets is feasible. Water pressures between 20 and 120 MPa with an orifice of 0.6 mm were used to create waterjets to drill blind boring...

  20. Impacto de la nutrición en la evolución de la enfermedad inflamatoria intestinal Impact of nutritional treatment in the evolution of inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    M.ª D. Ballesteros Pomar

    2010-04-01

    Full Text Available La enfermedad inflamatoria intestinal es una entidad de etiopatogenia aún no bien conocida, con importantes implicaciones nutricionales y metabólicas, por la alta prevalencia de malnutrición que conlleva; por la posible implicación de factores dietéticos en su patogenia; y por la hipótesis de que la intervención nutricional pudiera ser un tratamiento primario de la enfermedad. Algunos nutrientes, además de su función exclusivamente nutricional, podrían inducir un bajo estímulo antigénico, regular respuestas inflamatorias e inmunológicas y estimular el trofismo de la mucosa intestinal. La evidencia disponible actual apoya el empleo de nutrición enteral en enfermedad de Crohn como terapia primaria en adultos si el tratamiento con corticoides no es posible (fracaso o contraindicación (grado de recomendación A o bien en terapia combinada con fármacos en pacientes malnutridos y estenosis inflamatoria del intestino. En los pacientes en remisión clínica duradera no se ha demostrado beneficio de la nutrición enteral o suplementos en ausencia de déficits nutricionales. No se recomienda el uso de fórmulas elementales ni modificadas (glutamina, ácidos grasos omega 3. En colitis ulcerosa, no se ha demostrado la influencia de la nutrición sobre la actividad de la enfermedad, aunque disponemos de datos prometedores sobre el papel de los ácidos grasos w3 con cubierta entérica y de un posible papel de los probióticos. En el tratamiento y profilaxis de la pouchitis crónica, el empleo de probióticos puede tener un papel (VSL#3. La nutrición debe considerarse un componente integral en el manejo de los pacientes con EII.Inflammatory bowel disease is an entity with not wellknown pathogenesis, and important nutritional and metabolic implications because of the high prevalence of malnutrition, the possible implication of dietary factors in its pathogenesis and because of the hypothesis that nutritional intervention could be a primary

  1. Oxygen, nitric oxide and articular cartilage

    Directory of Open Access Journals (Sweden)

    B Fermor

    2007-04-01

    Full Text Available Molecular oxygen is required for the production of nitric oxide (NO, a pro-inflammatory mediator that is associated with osteoarthritis and rheumatoid arthritis. To date there has been little consideration of the role of oxygen tension in the regulation of nitric oxide production associated with arthritis. Oxygen tension may be particularly relevant to articular cartilage since it is avascular and therefore exists at a reduced oxygen tension. The superficial zone exists at approximately 6% O2, while the deep zone exists at less than 1% O2. Furthermore, oxygen tension can alter matrix synthesis, and the material properties of articular cartilage in vitro.The increase in nitric oxide associated with arthritis can be caused by pro-inflammatory cytokines and mechanical stress. Oxygen tension significantly alters endogenous NO production in articular cartilage, as well as the stimulation of NO in response to both mechanical loading and pro-inflammatory cytokines. Mechanical loading and pro-inflammatory cytokines also increase the production of prostaglandin E2 (PGE2. There is a complex interaction between NO and PGE2, and oxygen tension can alter this interaction. These findings suggest that the relatively low levels of oxygen within the joint may have significant influences on the metabolic activity, and inflammatory response of cartilage as compared to ambient levels. A better understanding of the role of oxygen in the production of inflammatory mediators in response to mechanical loading, or pro-inflammatory cytokines, may aid in the development of strategies for therapeutic intervention in arthritis.

  2. Tratamiento, mediante bloqueo de moléculas CD20 con Rituximab, en miopatías Inflamatorias Idiopáticas refractarias a tratamiento convencional

    OpenAIRE

    Chinchilla Palomares, Eduardo

    2012-01-01

    Las miopatías inflamatorias idiopáticas (MII) constituyen un grupo heterogéneo de enfermedades adquiridas, de probable mecanismo inflamatorio autoinmune, que se caracterizan por debilidad muscular e infiltrado inflamatorio local o difuso, junto con necrosis de las fibras musculares, en la biopsia muscular. Afectan preferentemente a la musculatura estriada. Dentro de este grupo se incluyen tres variantes principales: la dermatomiositis (DM), la polimiositis (PM) y la miositis con cuerpos de in...

  3. Aftas severas como manifestación de enteropatía inflamatoria

    OpenAIRE

    Roude, A.; Maganini, C.; Tauler, T.

    2015-01-01

    la Celiaquía es un desorden sistémico con base inmunológica causado por la ingesta de gluten y otras proteínas similares que afecta a personas con predisposición genética. La interacción entre el gluten y el sistema inmunológico del paciente puede manifestarse además a diferentes niveles: piel, articulaciones, riñón y en la mucosa oral (estomatitis aftosa redicivante). Descripción del caso: se presenta a la consulta derivada por su odontóloga particular, un paciente de sexo femenino, 39 años ...

  4. Intra-Articular Osteoid Osteoma Mimicking Juvenile Arthritis

    Directory of Open Access Journals (Sweden)

    Sidi Yaya Traore

    2014-01-01

    Full Text Available In case of intra-articular osteoid osteoma, misdiagnosis as juvenile arthritis may occur, delaying adequate treatment. We report cases of intra-articular osteoid osteomas in children that were misdiagnosed and initially inappropriately treated with intra-articular corticoid injection. Diagnosis of osteoid osteoma was finally given by CT-scan and appropriate treatment by radiofrequency ablation or surgical ablation was performed. Clinicians and radiologists should be aware of the potentially confusing clinical and imaging findings associated with intra-articular osteoid osteoma.

  5. Metric analysis of loading magnitudes at articular and non-articular weight-bearing surfaces in human calcaneus.

    Science.gov (United States)

    Mahato, Niladri Kumar; Murthy, S Sathiya Narayana

    2013-03-01

    The calcaneus is axially loaded at its articular interface with the talus. A large bulk of this load is transmitted to the ground across the non-articular tubercles at the plantar surface of the bone. A small part of the incumbent load sustained by the calcaneus is directed towards the forefoot at the calcaneo-cuboid junction. This study investigates the proportion of load distributed across the articular and non-articular surfaces of the calcaneus. The present study demonstrates strong and significant correlation between some of the load bearing variables and suggests the need for further investigations to understand the effect of angular aspects of axial loading on the calcaneus. Accounting for the relative distribution of weight across the articular and non-articular areas may enable us to appreciate the internal trabecular structure of the calcaneus in light of its clinical importance.

  6. Efectividad y seguridad de la viscosuplementación con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA para el tratamiento del dolor secundario a gonartrosis Efficacy and safety of single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA for gonarthrosis pain treatment

    Directory of Open Access Journals (Sweden)

    M. M. Monerris Tabasco

    2012-10-01

    Full Text Available Objetivos: valorar la efectividad y seguridad de la inyección de dosis única de ácido hialurónico estabilizado de origen no animal (NASHA para el tratamiento del dolor secundario a gonartrosis. Material y métodos: se han incluido un total de 37 pacientes afectos de gonartrosis diagnosticada previamente por el Traumatólogo/Reumatólogo en los que ha fracasado el tratamiento conservador y/o que no son tributarios de tratamiento quirúrgico. Se les ha efectuado una infiltración en dosis única de ácido hialurónico estabilizado no animal (NASHA, Durolane®. Se han recogido datos demográficos, efectos adversos e intensidad del dolor (valorada mediante escala verbal numérica y puntuación en los cuestionarios Western Ontario and McMaster Universities Osteoartritis Index (WOMAC y Barthel -basal, a las 2 semanas, a los 3 meses y a los 6 meses de la infiltración-. Se ha considerado efectiva una disminución ≥ 30% durante más de 3 meses en las puntuaciones basales. Resultados: los pacientes son mayoritariamente mujeres (83,8%, con una edad media de 72,8 años (desviación típica -S- = 8,4 e índice de masa corporal medio (IMC 31,9 (S = 6,9. La rodilla infiltrada es izquierda en el 51,7%, derecha en el 41,4% y bilateral en el 6,9% de los pacientes. Han presentado efectos adversos en forma de artralgias bien toleradas el 11,1% de los pacientes. En base a los resultados, la infiltración con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA por gonalgia de origen artrósico provoca una reducción estadísticamente significativa en la intensidad del dolor (escala verbal numérica y WOMAC y de la capacidad funcional (WOMAC en todos los intervalos valorados. Se ha producido una reducción ≥ 30% en la intensidad del dolor en el 54% (valor que coincide con la reducción en la puntuación WOMAC de dolor, en la rigidez en el 62,1% y en la capacidad funcional en el 48,6% de los pacientes. Conclusiones: en nuestros

  7. Fisiopatología celular de la osteoartritis: el condrocito articular como protagonista = Osteoarthritis cellular pathophysiology: The articular chondrocyte as a central player

    Directory of Open Access Journals (Sweden)

    Sánchez Naranjo, Julio César

    2011-06-01

    Full Text Available La osteoartritis es una de las enfermedades más prevalentes y que más discapacidad produce en todo el mundo, lo que ocasiona costos altos para el paciente y la sociedad. En años recientes se ha venido obteniendo información importante sobre el funcionamiento normal del condrocito, la única célula presente en el cartílago articular y responsable de la síntesis de matriz extracelular. El condrocito responde a las condiciones fluctuantes del medio, generadas por los cambios de presión, modificando su composición iónica y alterando el transporte de solutos y agua en su membrana. Esta capacidad de respuesta es clave para el mantenimiento de la matriz extracelular y, por ende, de un cartílago funcional. Diversos factores relacionados con enfermedades crónicas metabólicas inician una cascada de eventos que termina con una respuesta inadecuada del condrocito ante la carga mecánica, lo cual lleva a un predominio del catabolismo de la matriz y a un cartílago defectuoso que es la base del desarrollo de la osteoartritis. En este proceso están implicadas diversas citocinas y hormonas que afectan la homeostasis del cartílago y que pueden constituirse en blancos terapéuticos prometedores.

  8. Pérdida del sentido del olfato: profundizando en su epidemiología, causas rinosinusales y posibilidades terapéuticas

    OpenAIRE

    Mariño, Franklin

    2014-01-01

    [spa] FUNDAMENTO: A pesar de la importancia del olfato para la nutrición, seguridad y calidad de vida, la prevalencia y factores de riesgo del deterioro olfativo en nuestra población no han sido bien estudiados. La patología inflamatoria nasosinusal (rinitis/rinosinusitis) causa disfunción olfatoria y, aunque existe asociación entre patología nasosinusal y bronquial, se desconoce si la pérdida del olfato puede constituir un factor diagnóstico. También se desconoce si el tratamiento médico me...

  9. Modulación inflamatoria en el shock traumático

    OpenAIRE

    MATEO DE ACOSTA A,DAVID A; BEDOLLA O,EDGAR; MAKIPOUR J,JOHN; WAISSBLUTH G,JHONELLE A

    2010-01-01

    Universalmente se considera el Shock hipovolémico de origen hemorrágico como una importante causa de morbi-mortalidad. Durante los últimos años se ha redefinido los conceptos de la reanimación con líquidos intravenosos en los pacientes con choque hipovolémico y establecido los conceptos de reanimación hipotensa con el uso de nuevos coloides derivados del almidón, tales como el hidroxietil-almidón en solución electrolítica balanceada (Hextend®). Así mismo, se ha reportado el beneficio que conl...

  10. Dolor osteomuscular y reumatológico Osteomuscular and rheumatic pain

    OpenAIRE

    J. L. Rodríguez-Hernández

    2004-01-01

    Dentro del dolor osteomuscular y reumatológico encontramos varias entidades. La osteoartrosis u osteoartritis es una enfermedad inflamatoria articular que produce alteraciones estructurales en el cartílago hialino articular y esclerosis del hueso subcondral. Tiene origen multifactorial con síntomas localizados en las articulaciones afectadas y su tratamiento va dirigido al dolor, inflamación, funcionalidad y prevención de deformidades. La artritis reumatoide es una enfermedad crónica que afec...

  11. Efectos de la Acumulación del Péptido Beta Amiloide en Tejido Cerebral de Ratones PS1xAPP modelos de la Enfermedad del Alzheimer.

    OpenAIRE

    Jiménez Muñoz, Sebastián

    2017-01-01

    OBJETIVOS 1. Estudio de la respuesta inflamatoria en hipocampo del doble transgénico, modelo de la Enfermedad de Alzheimer, PS1M146L/APP751SL. Evaluación de la misma con el transcurso de la edad del animal, y caracterización del cambio fenotípico sufrido en la activación de la microglial.   2. Evaluación del efecto tóxico producido por la acumulación de formas oligoméricas solubles a edades avanzadas en el modelo trans...

  12. [Extra-articular manifestations of seronegative spondylarthritis].

    Science.gov (United States)

    Cammelli, Daniele

    2006-05-01

    Seronegative spondylarthritis are frequently characterised by extra-articular manifestations. They are frequently in recurrent uveitis. Between the cutaneous manifestations should be mentioned erythema nodosum, typical of inflammatory bowel diseases, and keratoderma blenorrhagicum, in the Reiter's syndrome. Cardiac complications in ankylosing spondylitis (AS) include aortic valvular regurgitation and arrhythmia and, more rarely, mitral valvulopathy, cardiomyopathy and pericarditis. Pulmonary involvement in AS includes ventilatory restrictive syndrome and fibro-bullous disease of the apex. Vertebral osteoporosis is a very important extra-articular manifestation because of the possibility of spontaneous fractures of the vertebrae. Central neurological manifestations include medullary compression from cervical sub-luxation while the most important peripheral involvements are lumbar stenosis and the cauda equina syndrome. Type AA amyloidosis is a rare late complication of the AS, possible cause of death especially in patients with aggressive disease. Kidney complications can be observed as consequences of prolonged anti-inflammatory therapy, but the most frequent renal complications are amyloidosis and mesangial IgA segmental and focal glomerulonephritis.

  13. PRP and Articular Cartilage: A Clinical Update

    Directory of Open Access Journals (Sweden)

    Antonio Marmotti

    2015-01-01

    Full Text Available The convincing background of the recent studies, investigating the different potentials of platelet-rich plasma, offers the clinician an appealing alternative for the treatment of cartilage lesions and osteoarthritis. Recent evidences in literature have shown that PRP may be helpful both as an adjuvant for surgical treatment of cartilage defects and as a therapeutic tool by intra-articular injection in patients affected by osteoarthritis. In this review, the authors introduce the trophic and anti-inflammatory properties of PRP and the different products of the available platelet concentrates. Then, in a complex scenario made of a great number of clinical variables, they resume the current literature on the PRP applications in cartilage surgery as well as the use of intra-articular PRP injections for the conservative treatment of cartilage degenerative lesions and osteoarthritis in humans, available as both case series and comparative studies. The result of this review confirms the fascinating biological role of PRP, although many aspects yet remain to be clarified and the use of PRP in a clinical setting has to be considered still exploratory.

  14. PRP and Articular Cartilage: A Clinical Update

    Science.gov (United States)

    Rossi, Roberto; Castoldi, Filippo; Michielon, Gianni

    2015-01-01

    The convincing background of the recent studies, investigating the different potentials of platelet-rich plasma, offers the clinician an appealing alternative for the treatment of cartilage lesions and osteoarthritis. Recent evidences in literature have shown that PRP may be helpful both as an adjuvant for surgical treatment of cartilage defects and as a therapeutic tool by intra-articular injection in patients affected by osteoarthritis. In this review, the authors introduce the trophic and anti-inflammatory properties of PRP and the different products of the available platelet concentrates. Then, in a complex scenario made of a great number of clinical variables, they resume the current literature on the PRP applications in cartilage surgery as well as the use of intra-articular PRP injections for the conservative treatment of cartilage degenerative lesions and osteoarthritis in humans, available as both case series and comparative studies. The result of this review confirms the fascinating biological role of PRP, although many aspects yet remain to be clarified and the use of PRP in a clinical setting has to be considered still exploratory. PMID:26075244

  15. Toward patient-specific articular contact mechanics.

    Science.gov (United States)

    Ateshian, Gerard A; Henak, Corinne R; Weiss, Jeffrey A

    2015-03-18

    The mechanics of contacting cartilage layers is fundamentally important to understanding the development, homeostasis and pathology of diarthrodial joints. Because of the highly nonlinear nature of both the materials and the contact problem itself, numerical methods such as the finite element method are typically incorporated to obtain solutions. Over the course of five decades, we have moved from an initial qualitative understanding of articular cartilage material behavior to the ability to perform complex, three-dimensional contact analysis, including multiphasic material representations. This history includes the development of analytical and computational contact analysis methods that now provide the ability to perform highly nonlinear analyses. Numerical implementations of contact analysis based on the finite element method are rapidly advancing and will soon enable patient-specific analysis of joint contact mechanics using models based on medical image data. In addition to contact stress on the articular surfaces, these techniques can predict variations in strain and strain through the cartilage layers, providing the basis to predict damage and failure. This opens up exciting areas for future research and application to patient-specific diagnosis and treatment planning applied to a variety of pathologies that affect joint function and cartilage homeostasis.

  16. Mapeo linfático y biopsia del ganglio centinela en cáncer de pene. Estudio de factibilidad y reporte preliminar

    OpenAIRE

    Narciso Hernández-Toris; Joel Quintero-Becerra; José Francisco Gallegos-Hernández; Ramiro Flores-Ojeda; Isabel Alvarado-Cabrero; Donaciano Flores-López; Pablo Pichardo-Romero

    2007-01-01

    La mayoría de los pacientes con carcinoma epidermoide invasor de pene no tiene metástasis ganglionares inguinales al momento del diagnóstico; en 50 % de los ganglios palpables la causa es inflamatoria. El tratamiento del cáncer peneano implica resección del tumor primario y linfadenectomía inguinal, sin embargo, la morbilidad derivada del procedimiento es alta y la utilidad cuestionable en pacientes sin metástasis en ganglios disecados. El mapeo linfático con biopsia del ganglio centinela (ML...

  17. Artritis reumatoide y tabaco. Efecto del tabaco sobre la actividad, discapacidad y daño radiológico en la artritis reumatoide y su relación con los marcadores serológicos de la enfermedad

    OpenAIRE

    2012-01-01

    [spa] La artritis reumatoide (AR) es la artropatía inflamatoria crónica más frecuente, afecta aproximadamente el 0.5% - 1% de la población general y causa una progresiva destrucción articular, discapacidad y disminución de la expectativa de vida. La etiología de la AR es desconocida y su patogenia solo parcialmente conocida al día de hoy. En los últimos años se han estudiado e identificado múltiples factores de riesgo para su desarrollo. Sabemos que intervienen factores genéticos y ambientale...

  18. Tratamiento con electrocauterización de las lesiones premalignas del cérvix

    OpenAIRE

    Israel Meza G.

    2014-01-01

    Se presentaron los resultados del tratamiento con electrocauterización de las neoplasias intraepiteliales del cérvix en 430 pacientes atendidas en el Hospital Universitario del Valle, en el Hospital San Juan de Dios y en el Centro Hospital Cañaveralejo en Cali, Colombia, entre 1982 y 1992. Inicialmente se seleccionaron 455 mujeres que consultaron con citologías anormales (inclusive Papanicolau II) con cambios coilocíticos y atipias inflamatorias. Para el análisis final sólo se incluyeron 430 ...

  19. Enfermería y artritis reumatoide. Revisión bibliográfica

    OpenAIRE

    Pasquier Álvarez, Miriam

    2016-01-01

    La artritis reumatoide es una enfermedad inflamatoria crónica, autoinmune sistémica y multiorgánica, de origen desconocido. Afecta de esta manera, a multitud de tejidos y órganos, comprometiendo principalmente a las articulaciones con sinovitis inflamatoria y proliferativa no supurativa, que progresa a destrucción del cartílago articular y anquilosis articular (predominando de 3 a 5 veces más en mujeres). El paciente con AR necesita ser evaluado de forma individualizada por el profesional de ...

  20. Color Doppler US in extra-articular rheumatoid arthritis. Early results; L'eco Doppler nell'artrite reumatoide con localizzazione extra-articolare: esperienza preliminare

    Energy Technology Data Exchange (ETDEWEB)

    Midiri, M. [Bari Politcenico, Bari (Italy). Ist. di Radiologia; Iovane, A.; Finazzo, M.; Brancatelli, G.; Gallo, C.; Lagalla, R. [Palermo Politecnico Universitario Paolo Giaccone, Palermo (Italy). Ist. di Radiologia

    1999-09-01

    The paper investigates the role of color and power Doppler imaging in staging extra-articular involvement, monitoring local inflammatory changes and drug treatment response. [Italian] Scopo del lavoro e' quello di analizzare l'introduzione dell'ecografia con color power Doppler, che offre possibilita' di integrazione dell'ecografia, con particolare riferimento alla dimostrazione del grado di coinvolgimento extra-articolare, allo stato evolutivo, della flogrosi locale e alla risposta al trattamento farmacologico.

  1. Vitiligo, con énfasis en su variante inflamatoria Vitiligo, with emphasis in its inflammatory variant

    Directory of Open Access Journals (Sweden)

    C I Vera

    2009-03-01

    Full Text Available El vitiligo inflamatorio es un trastorno melanocitopénico adquirido, de baja frecuencia con características clínicas e histológicas propias. Ocurre en ambos sexos, a cualquier edad. Su fisiopatogenia parece involucrar mecanismos autoinmunes. En su evolución es frecuente la desaparición del componente inflamatorio que resulta en una mácula hipopigmentada clásica; a ello debe anticiparse también nuestra elección terapéutica. Se describe un paciente con vitiligo inflamatorio de resolución espontánea, junto a una revisión crítica de la bibliografía. Se discute si representa una variante de vitiligo vulgar o una entidad independiente.Inflammatory vitiligo is a low frequency melanocytopenic acquired entity with clinical and histological features of it 's own. It occurs in both sexes at any age. Fisiopathogenesis may involve autoimmune mechanisms. It's evolution most commonly ends up in a classic hypopigmented maculae, therefore our therapeutic choice has to be oriented to this outcome. A patient with inflammatory vitiligo is described along a critical review of the literature. It is discussed if it represents a variant of common vitiligo or an independent entity.

  2. Ozonoterapia sistémica e intra-articular en la artritis de la articulación temporomandibular por artritis reumatoide

    Directory of Open Access Journals (Sweden)

    Ivonne Méndez-Pérez

    2010-01-01

    Full Text Available Se estudió el efecto de la ozonoterapia intra-articular combinada con la vía sistémica (vía rectal y se comparó con la sola aplicación por vía intra-articular en pacientes con artritis de la articulación temporomandibular (ATM por artritis reumatoide (AR mediante la evaluación clínica del dolor a la masticación, chasquido y trismo. Fueron estudiados veinte pacientes, divididos en dos grupos de diez cada uno, el primero recibió ozonoterapia intra-articular (concentración de ozono 10 mg/L y volumen de 3 mL, a razón de dos aplicaciones por semana, durante cinco semanas, y el segundo, terapia combinada (igual al primer grupo más ozono administrado por insuflación rectal, a una concentración de 30 hasta 40 mg/L y un volumen de 100 hasta 200 mL, veinte aplicaciones. Se evaluó el grosor del cartílago articular (por ultrasonido, al inicio y al final del tratamiento al igual que los síntomas clínicos: dolor a la masticación, chasquido y trismo. Como resultado, se obtuvo una disminución significativa de todos los síntomas estudiados, así como del grosor del cartílago articular diagnosticado en el estudio ultrasonográfico, teniendo una respuesta más rápida en el grupo de la terapia combinada. Se concluyó que ambas formas de tratamiento demuestran efectos beneficiosos en la artritis de la articulación temporomandibular de pacientes con artritis reumatoide, aunque la terapia combinada resulta la más eficiente, resultado que no ha sido reportado con anterioridad.

  3. Efecto de las cargas articulares sobre el flujo y pH salival Effect of TMJ loading on salivary flow and pH

    OpenAIRE

    RJ Castro; Bravo, C; Alcaino,V; RA Giacaman

    2011-01-01

    Una alteración del flujo salival es clave en el desarrollo de caries, enfermedad periodontal e infecciones oportunistas. El flujo salival está determinado por diversos estímulos que actúan sobre receptores de distinta naturaleza, entre ellos mecanoreceptores articulares. Algunos estudios demuestran que las cargas articulares actúan sobre estos receptores, modificando cualitativa y cuantitativamente la secreción salival. El objetivo de este estudio fue determinar si existe una relación entre l...

  4. Effects of intra articular tramadol on articular cartilage and synovium of rats

    Directory of Open Access Journals (Sweden)

    Musa Kola

    2015-12-01

    Full Text Available Objective: To investigate the effects of intra articular tramadol injection on articular cartilage and synovium in rat knee joint. Methods: After Animal Ethical Committee approval, a total of 20 Sprague-Dawley rats were used and divided into 4 groups. Each group was composed of 5 rats. 0.2 ml of tramadol HCl was injected into the right knee joints and left knee joints of all the rats were considered as control. Control side joints received saline injection. Rats were sacrificed with ketamin on 1st, 7th, 14th and 21st days and knee joints were removed. Obtained tissue samples were decalcified and were dyed with Hematoxylin-eosin and Masson’s trichrome stain and examined by light microscopy for the presence of inflammation in periarticular area and synovia. Results: Congestion of synovial veins and perivascular cell infiltration were observed in tramadol group on days 1 and 7 (P < 0.05. The inflammation process was replaced by fibrosis on day 14 and fibrosis was significantly decreased on day 21. Conclusion: Intra articular tramadol should be used cautiously, keeping in mind that it may cause synovial inflammation in early phases and fibrosis in late phases. J Clin Exp Invest 2015; 6 (4: 337-342

  5. A population-based study on the incidence of inflammatory bowel disease in Oviedo (Northern Spain Incidencia de la enfermedad inflamatoria intestinal (EII en población general en el área de Oviedo

    Directory of Open Access Journals (Sweden)

    L. Rodrigo

    2004-05-01

    Full Text Available Objective: to assess the incidence of inflammatory bowel disease in Oviedo (Northern Spain, and to describe the clinical features of new patients. Patients and methods: a prospective population-based study was made at the Health Area IV, Principality of Asturias (Oviedo, 312,324 inhabitants. All new diagnosed patients with inflammatory bowel disease were registered over a 2-year period. Results: a total of 85 patients were included, 47 of these with ulcerative colitis (UC, 37 with Crohn's disease (CD, and 1 with undetermined colitis. The overall adjusted incidence rate of UC and CD per 10(5 inhabitants between 15-64 years was 9.1 (95% CI: 5-13.1 and 7.5 (95% CI: 3.8-11.2, respectively. The global male/female ratio was 0.9, without significant differences between both diseases. CD patients were younger than those with UC (33 ± 15 years vs 45 ± 20 years; p Objetivo: conocer la incidencia de enfermedad inflamatoria intestinal en el área de Oviedo y describir las características clínicas de los nuevos pacientes. Pacientes y métodos: estudio prospectivo poblacional en el Área Sanitaria IV del Principado de Asturias (Oviedo, 312.324 habitantes. Fueron registrados todos los pacientes nuevos diagnosticados de enfermedad inflamatoria intestinal en un periodo de 2 años consecutivos. Resultados: se incluyeron un total de 85 pacientes, 47 con colitis ulcerosa (CU, 37 con enfermedad de Crohn (EC y 1 con colitis indeterminada (CI. La tasa de incidencia ajustada por 10(5 habitantes entre 15 y 64 años, de CU y EC, fue de 9,1 para CU (IC95%: 5-13,1 y 7,5 para la EC (IC95%: 3,8-11,2. La proporción hombre/mujer fue de 0,9, sin diferencias significativas entre ambas enfermedades. Los pacientes con EC eran más jóvenes que los que tenían CU (33 ± 15 años vs 45 ± 20 años; p<0,05. La mayor parte de los pacientes con EC tenían menos de 35 años (65%, mientras que los que presentaban CU fueron diagnosticados entre los 25 y 64 años (81%. La extensi

  6. Is safety infliximab during pregnancy in patients with inflammatory bowel disease? ¿El tratamiento con infliximab es seguro durante el embarazo en pacientes con enfermedad inflamatoria intestinal?

    Directory of Open Access Journals (Sweden)

    Federico Argüelles-Arias

    2012-02-01

    foetus. In fact, in our study and in some cases, its withdrawal may lead to a worsening of the disease. However, further control studies are required with larger samples to obtain more representative findings.Introducción: la enfermedad inflamatoria intestinal (EII es un trastorno crónico que debuta en la mayoría de los casos durante la edad reproductiva. Existen pocos datos sobre la seguridad durante el embarazo de los tratamientos disponibles, entre ellos los denominados biológicos, y estos están basados en resultados de casos esporádicos. Objetivos: determinar la seguridad del tratamiento con infliximab (IFX durante el embarazo en mujeres con EII. Un segundo objetivo es observar el efecto que sobre la actividad de la enfermedad tiene el abandono del tratamiento. Material y métodos: se trata de un estudio retrospectivo en el que se incluyeron mujeres con EII embarazadas y que estaban en tratamiento con IFX durante el embarazo. Se incluyeron en el estudio a 5 hospitales de España. La actividad de la enfermedad se midió según el CDAI en la enfermedad de Crohn (EC y la de la colitis ulcerosa (CU según el índice de Truelove-Witts en cada trimestre del embarazo. La edad gestacional, el peso y las enfermedades del feto se determinaron al nacimiento. Resultados: se incluyeron doce mujeres con una edad media de 29 años, 4 diagnosticadas de CU y 8 de EC, con una duración media de la enfermedad de 7 años. Todas salvo una, que se diagnosticó durante el embarazo estaban siendo tratadas con IFX en el momento de la concepción. Seis pacientes recibieron el tratamiento de forma ininterrumpida durante todo el embarazo, 2 suspendieron el tratamiento de forma voluntaria y a tres se les suspendió el tratamiento en el tercer trimestre. Recibieron una dosis media de IFX de 400 mg cada 8 semanas. De las 6 pacientes que recibieron tratamiento continuo, el 50% se mantuvo en remisión. De las pacientes que abandonaron el tratamiento, un 83,3% (todas menos una presentaron un

  7. Consecuencias clínicas de la persistencia de actividad inflamatoria en la arteritis de células gigantes. Estudio de factores implicados

    OpenAIRE

    García Martínez, Ana

    2010-01-01

    La arteritis de células gigantes (ACG) afecta arterias de mediano y gran calibre. La inflamación de la carótida y sus ramas da lugar a los síntomas craneales típicos de la enfermedad. Las lesiones inflamatorias expresan gran cantidad de mediadores que provocan la muerte celular y la destrucción de fibras elásticas. El remodelado de la pared arterial puede dar lugar a alteraciones estructurales vasculares, como la aparición de estenosis arteriales que producen síntomas isquémicos o el desarrol...

  8. Moléculas de adhesión endotelial: nuevas dianas terapéuticas en la enfermedad inflamatoria intestinal

    OpenAIRE

    Soriano Izquierdo, Antonio

    2004-01-01

    INTRODUCCIÓN: El tratamiento de la enfermedad inflamatoria intestinal se ha basado en el uso de aminosalicilatos corticoides e inmunosupresores, que ayudan a controlar los brotes de la enfermedad, aunque no consiguen su curación. El bloqueo de las moléculas de adhesión endotelial, que permiten el reclutamiento de leucocitos desde el lecho vascular hacia el área inflamada, podría ser una diana terapéutica útil en esta enfermedad.OBJETIVOS: 1. Determinar el valor de las moléculas de adhesión en...

  9. Papel de la ventilación mecánica durante la circulación extracorporea sobre los mediadores de la respuesta inflamatoria

    OpenAIRE

    López Gomez, Amparo

    2015-01-01

    RESUMEN TESIS: PAPEL DE LA VENTILACIÓN MECÁNICA DURANTE LA CIRCULACIÓN EXTRACORPÓREA SOBRE LOS MEDIADORES DE LA RESPUESTA INFLAMATORIA. La Cardiopatía Isquémica (CI) representa la mayor causa de mortalidad en países desarrollados. En España, supone el mayor número de muertes cardiovasculares, siendo el infarto agudo de miocardio (IMA) la enfermedad isquémica más frecuente. Datos recientes sugieren que se ha producido un aumento de la prevalencia de pacientes con CI . La revasculariza...

  10. [Familial articular chondrocalcinosis: study of an Alsatian family].

    Science.gov (United States)

    Netter, P; Loeuille, D; Jouzeau, J Y; Gillet, P; Peterschmitt, J; Pourel, J; Gaucher, A

    2001-01-01

    Familial articular chondrocalcinosis is a chronic articular disease characterized by acute intermittent attacks of arthritis, presence of calcium pyrophosphate dihydrate crystal in synovial fluid, cartilage and periarticular soft tissue and by x rays calcium deposition in articular cartilage. A family originating from Alsace, with an autosomal dominant transmission has been studied. As in English and Argentinean families, a linkage to the short arm of chromosome 5p has been found. These results suggest that a defective gene at this location may be related to the chondrocalcinosis in these families.

  11. Asma bronquial. Estado del arte.

    Directory of Open Access Journals (Sweden)

    Jorge Salazar

    2009-10-01

    Full Text Available Para infinidad de personas el asma es su problema de salud. El diagnóstico y el tratamiento varían dependiendo de la magnitud del compromiso y la causa que produce la reacción inflamatoria en los pulmones. La prevención y el tratamiento serán mejores si la población y los pacientes reconocen la necesidad de evitar determinadas exposiciones ambientales y el uso de medicamentos con la frecuencia necesaria. Ahora los médicos generales conocen mejor la fisiología y patología de esta enfermedad y los mecanismos de acción de los diferentes medicamentos. El tratamiento con aerosol debe comprenderse mejor para evitar efectos colaterales en los pacientes y darles una mejor calidad de vida. Se discuten los nuevos tratamientos para el estado asmático y en las unidades de cuidados intensivos.

  12. Ozonoterapia sistémica e intra-articular en la artritis de la articulación temporomandibular por artritis reumatoide

    OpenAIRE

    Ivonne Méndez-Pérez; Alejandro del Cerro-Montesino; Roosevelt Cámbara-Peña; Julio Martínez-Godíne; Silvia Menéndez-Cepero

    2010-01-01

    Se estudió el efecto de la ozonoterapia intra-articular combinada con la vía sistémica (vía rectal) y se comparó con la sola aplicación por vía intra-articular en pacientes con artritis de la articulación temporomandibular (ATM) por artritis reumatoide (AR) mediante la evaluación clínica del dolor a la masticación, chasquido y trismo. Fueron estudiados veinte pacientes, divididos en dos grupos de diez cada uno, el primero recibió ozonoterapia intra-articular (concentración de ozono 10 mg/L y ...

  13. Fibroma aponeurótico calcificante intra articular. Presentación de un caso.

    Directory of Open Access Journals (Sweden)

    José Ramón Hernández Puerto

    2010-02-01

    Full Text Available El fibroma aponeurótico juvenil es un tumor infrecuente del tejido blando que se localiza con mayor periodicidad en niños y adolescentes en la región distal de las extremidades, aunque se reportan casos en otras edades y localización. Se presenta un paciente de 18 años de edad, masculino con fibroma aponeurótico calcificante en la rodilla derecha intra articular, con una localización poco común. El diagnóstico se realizó por exéresis quirúrgica del tumor. Se hace referencia al cuadro clínico, terapéutica efectuada y seguimiento por 3 años. Se revisó literatura actualizada referente al tema. Por ser un caso infrecuente se decide su publicación.

  14. Patología infecciosa: vulvovaginitis, enfermedades de transmisión sexual, enfermedad inflamatoria pélvica, abscesos tubo-ováricos Infectious pathology: vulvovaginitis, sexually transmitted diseases, pelvic inflammatory disease, tubo-ovarian abscesses

    Directory of Open Access Journals (Sweden)

    M. Ibarrola

    2009-01-01

    Full Text Available Las enfermedades de transmisión sexual son aquellas en las que la principal vía de infección es el contacto íntimo. Son numerosas las pacientes que acuden a urgencias por esta causa, tanto por la clínica como por las implicaciones sociales. Los síntomas más frecuentes son dolor abdominal bajo, sangrados vaginales, o flujo vaginal excesivo o molesto. Las vulvovaginitis son uno de los problemas principales en la práctica clínica diaria del ginecólogo. La úlcera genital cuya etiología principal es el herpes, seguida de la sífilis y el chancroide incrementa el riesgo para contraer la infección por el VIH y modifica el curso de otras enfermedades de transmisión sexual. La enfermedad pélvica inflamatoria engloba a las infecciones del tracto genital superior femenino. La importancia del diagnóstico precoz y su tratamiento adecuado reside tanto por las complicaciones en la fase aguda como por las secuelas, que incluyen el dolor crónico y la esterilidad.Sexually transmitted diseases are those where the principal path of infection is through intimate contact. Numerous patients attend Accidents and emergencies for this reason, both because of the clinical features and because of social implications. The most frequent symptoms are lower abdominal pain, vaginal bleeding or excessive or troubling vaginal flow. Vulvovaginites are one of the principal problems in the everyday clinical practice of gynaecology. A genital ulcer whose principal aetiology is herpes, followed by syphilis and chancroid, increases the risk of contracting HIV infection and alters the course of other sexually transmitted diseases. Inflammatory pelvic disease encompasses infections of the upper female genital tract. The importance of early diagnosis and suitable treatment is both due to the complications in its acute phase and to its sequels, which include chronic pain and sterility.

  15. La p67-PHOX como un elemento esencial del sistema NADPH oxidasa de las células fagocíticas

    OpenAIRE

    1999-01-01

    Las células fagocíticas cumplen un papel fundamental en la defensa innata del huésped contra la invasión de microorganismos. Luego de ser fagocitados, uno de lo~ mecanismos utilizados para destruir dichos microorganismos es la producción de metabolitos intermedios del oxígeno generados a través del sistema NADPH oxidasa. Los radicales libres del oxígeno están al mismo tiempo involucrados en el daño tisular, que ocurre en muchas condiciones inflamatorias. La NADPH oxidasa es un complejo protei...

  16. [Structure of the articular cartilage in the middle aged].

    Science.gov (United States)

    Kop'eva, T N; Mul'diiarov, P Ia; Bel'skaia, O B; Pastel', V B

    1983-10-01

    In persons 17-83 years of age having no articular disorders 39 samples of the patellar articular cartilage, the articulated surface and the femoral head have been studied histochemically, histometrically and electron microscopically. Age involution of the articular cartilage is revealed after 40 years of age as a progressive decrease in chondrocytes density in the superficial and (to a less degree) in the intermediate zones. This is accompanied with a decreasing number of 3- and 4-cellular lacunae and with an increasing number of unicellular and hollow lacunae. In some chondrocytes certain distrophic and necrotic changes are revealed. In the articular matrix the zone with the minimal content of glycosaminoglycans becomes thicker and keratansulfate content in the territorial matrix of the cartilage deep zone grows large.

  17. Nuevas estrategias en el diagnóstico del cáncer asociado a las dermatomiositis y polimiositis

    OpenAIRE

    Trallero Araguás, Ernesto

    2012-01-01

    Descripció del recurs: el 01 setembre 2012 El diagnóstico de cáncer constituye un indicador de mal pronóstico en pacientes con dermatomiositis (DM) y polimiositis (PM) y se relaciona, además, con una parte importante de la mortalidad observada en estas entidades. Se estima que entre un 15% y un 30% de las DM y PM tienen un comportamiento paraneoplásico. La afectación inflamatoria del músculo y/o la piel parece originarse a partir de una reacción inmunológica cruzada entre antígenos del tej...

  18. The Frictional Coefficient of Bovine Knee Articular Cartilage

    Institute of Scientific and Technical Information of China (English)

    Qian Shan-hua; Ge Shi-rong; Wang Qing-liang

    2006-01-01

    The normal displacement of articular cartilage was measured under load and in sliding, and the coefficient of friction during sliding was measured using a UMT-2 Multi-Specimen Test System. The maximum normal displacement under load and the start-up frictional coefficient have similar tendency of variation with loading time. The sliding speed does not significantly influence the frictional coefficient of articular cartilage.

  19. Expresiones del CD44 en tejidos periapicales inflamados.

    OpenAIRE

    Siragusa, Martha; Dietrich, Gustavo; Pisterna, Gabriela; D'Arrigo, Mabel

    2012-01-01

    Recibido: Noviembre 2011 - Aceptado: Marzo 2012 El granuloma periapical es una lesión inflamatoria crónica causada por una infección poli bacteriana. Las moléculas de adhesión del CD44 están fuertemente expresadas en células variadas tales como los leucocitos, células parenquimatosas e incluyendo células endoteliales, en células epiteliales y en células musculares. Tiene interacción con el Acido Hialurónico, con el colágeno, lamininas y fibronectina y juega un rol importante en la migraci...

  20. Manejo clínico del quiste periapical

    OpenAIRE

    Clara Vergara Hernández

    2013-01-01

    ResumenEl quiste periapical es una lesión inflamatoria de los maxilares formada en el periápice de dientes con pulpa necrótica e infectada siendo una secuela directa de un granuloma apical, están asociados a la raíz dentaria y se encuentran con mayor frecuencia en el maxilar superior. Por lo general no provocan síntomas y su lenta evolución hace que el paciente no se percate del mismo hasta que aparece la asimetría facial. Se presenta un caso correspondiente a un paciente masculino con lesión...

  1. Estudio descriptivo de las células madre mesenquimales en la articulación artrósica y su aplicación en terapia celular para reparar cartílago articular humano

    OpenAIRE

    Hermida Gómez, Tamara

    2011-01-01

    [Resumen] La artrosis es una patología articular degenerativa caracterizada por el deterioro y la pérdida del cartílago articular. Dada su sintomatología, se trata de una de las enfermedades reumáticas más dolorosas e incapacitantes en la actualidad. Esta patología afecta a un elevado porcentaje de la población, por lo que se han desarrollado opciones terapéuticas para frenar y/o retardar su progresión y, además, regenerar la superficie del cartílago. No obstante, ninguna de ellas conduce a l...

  2. Lavado articular en el tratamiento de la artrosis de la rodilla: descripción de una nueva técnica y valoración de la eficacia y tolerancia de la misma

    OpenAIRE

    Caracuel Ruiz, Miguel Ángel

    2011-01-01

    El Lavado Articular (LA) es una medida terapéutica utilizada para el tratamiento de la patología articular, sobre articulaciones accesibles y desarrollada fundamentalmente en la patología de rodilla. El efecto del LA ha sido estudiado en pocas indicaciones concretas: artritis séptica, artritis reumatoide, condrocalcinosis y artrosis. Los objetivos de esta tesis son: 1) Valorar la eficacia del LA en pacientes con patología osteoarticular de rodilla (artrosis, condrocalcinosis y artritis). 2) C...

  3. Epidemiology of chronic inflammatory bowel disease in the Northern area of Huelva Estudio epidemiológico de la enfermedad inflamatoria intestinal en la zona norte de Huelva

    Directory of Open Access Journals (Sweden)

    A. Garrido

    2004-10-01

    Full Text Available Objective: to know the different epidemiologic aspects of chronic inflammatory bowel disease (IBD in the Northern area of the province of Huelva. Material and methods: we carried out a retrospective (1980-1996 and prospective (1996-2003 study of all patients diagnosed with IBD in the Northern area of Huelva, with 77,856 inhabitants. The distribution of Crohn's disease (CD and ulcerative colitis (UC was analyzed, as well as sex, age and smoking habit at the time of diagnosis, familial aggregation, appendicectomy rate, phenotype (anatomical site and clinical types, extraintestinal manifestations, and immunosuppressive therapy or surgical requirements. Results: 70 patients with IBD were studied, 40 with UC and 30 with CD. Sex distribution was 39 (55.7% males (55% with CD vs 56.6% with UC; NS and 31 (44.3% females (45% with CD vs 43.3% with UC; NS. Mean age at presentation was 44.7 ± 19.32 years in UC vs 32.3 ± 16.43 in CD; p Objetivo: conocer los distintos aspectos epidemiológicos de la enfermedad inflamatoria intestinal (EII en la zona norte de la provincia de Huelva. Material y métodos: se realizó un estudio retrospectivo (1980-1996 y prospectivo (1996-2003 sobre los pacientes diagnosticados de EII en la zona norte de Huelva con 77.856 habitantes. Se ha analizado la distribución de enfermedad de Crohn (EC y colitis ulcerosa (CU, sexo, edad y hábito tabáquico en el momento del diagnóstico, agregación familiar, antecedentes de apendicetomía, fenotipo (extensión y tipos clínicos, manifestaciones extraintestinales y necesidad de tratamiento inmunosupresor y/o quirúrgico. Resultados: se estudiaron 70 pacientes con EII, 40 con CU y 30 con EC. Un total de 39 (55,7% eran varones (55% en EC frente a 56,6% en CU; NS y 31 (44,3% mujeres (45% en EC frente a 43,3% en CU; NS. La media de edad en el momento de diagnóstico fue de 44,7±19,32 para CU frente a 32,3±16,43 para EC (p<0,001. La asociación familiar fue del 7,1%. Referían apendicectom

  4. Modelos animales para el estudio de la respuesta inflamatoria sistémica y de nutrición parenteral Animal models for the study of systemic inflammatory response and parenteral nutrition

    Directory of Open Access Journals (Sweden)

    J. M. Morán Penco

    2007-04-01

    Full Text Available El Síndrome de Respuesta Inflamatoria Sistémica (SRIS parece desencadenarse por la activación de un tipo de receptores llamados Toll-Like, propios de las células de respuesta inflamatoria y que, a través de señales citosólicas específicas, producen una cascada de reacciones que activan las Citocinas, Factores de Crecimiento y otros mediadores inflamatorios. En este trabajo, repasamos y discutimos varias clasificaciones de Modelos Animales para el estudio del SRIS y proponemos que estos modelos se dividan según los objetivos concretos a estudiar; que podrían ser los siguientes: 1º Para el estudio de los genes reguladores de los receptores Innatos y Adaptativos, de la respuesta inmunoinflamatoria. 2º Para el estudio de los receptores de señalización (Citocinas y Factores de Crecimiento. 3º Para el estudio de la respuesta frente a los señalizadores. 4º Para el estudio de tratamientos mediante bloqueo anti-inflamatorio específico (ILs, TNF y otros. 5º Modelos específicos de Sepsis. 6º Otros Modelos Inductores de SRIS. 7º Para el estudio de Modelos Terapéuticos diversos: -Tratamientos Anti-Inflamatorios. -Tratamientos Anticoagulantes: Inhibición de la Coagulación en ensayos Humanos-Fase II, con anticoagulantes: Antitrombina III, PCA y TFPI. -Tratamientos Antibióticos. -Tratamientos con Reposición de Volúmenes. -Tratamientos Quirúrgicos. En lo que respecta al apartado de Modelos animales para el estudio de la Nutrición Parenteral, podríamos hacer la siguiente clasificación y resumen de lo tratado: 1. Modelos Animales para el estudio de la Vía Parenteral de Administración. 2. Modelos para el estudio de la viabilidad, absorción y tolerancia locales en la vía de administración. 3. Modelos para el estudio de las Complicaciones. 4. Modelos animales para el estudio de la farmacodinamia, metabolización e investigación de la tolerancia de nuevas moléculas o substratos.The systemic inflammatory response syndrome (SRIS

  5. Estudo comparativo da analgesia entre bupivacaína e morfina intra-articular em osteoartrite de joelho Estudio comparativo de la analgesia entre bupivacaína y morfina intra-articular en osteoartritis de la rodilla Intra-articular bupivacaine and morphine for knee osteoarthritis analgesia. Comparative study

    Directory of Open Access Journals (Sweden)

    Miriam C B Gazi

    2005-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A osteoartrite é a mais freqüente entre as doenças articulares em pessoas idosas. O objetivo do estudo foi comparar o efeito analgésico da bupivacaína e da morfina por via intra-articular em pacientes portadores de osteoartrite de joelho. MÉTODO: Foram avaliados 39 pacientes em estudo duplamente encoberto, divididos de forma aleatória, em dois grupos: os do G1 (n = 18 receberam 1 mg (1 mL de morfina diluída em 9 mL de solução fisiológica a 0,9% e os do G2 (n = 21, 25 mg (10 mL de bupivacaína a 0,25% sem vasoconstritor, por via intra-articular. A intensidade da dor foi avaliada pela escala numérica e verbal nos momentos 0, 30, 60 minutos e 7 dias, em repouso e em movimento. Foram avaliados a necessidade de complementação analgésica com paracetamol (500 mg, a dose total de analgésico utilizado, a duração da analgesia e a qualidade da analgesia (pelo paciente. RESULTADOS: Dos 39 pacientes, 31 completaram o estudo. Não houve diferença significativa da intensidade da dor em repouso e em movimento entre os dois grupos nos momentos estudados. Não houve diferença entre os dois grupos no tempo entre a administração da solução e a necessidade de complementação analgésica. A dose média do paracetamol utilizada no primeiro dia da semana foi de 796 mg do G1 e de 950 mg no G2; a complementação na semana foi de 3578 mg no G1 e 5333 mg no G2. CONCLUSÕES: O efeito analgésico de 1 mg de morfina e de 25 mg de bupivacaína a 0,25% sem vasoconstritor intra-articular foram semelhantes.JUSTIFICATIVA Y OBJETIVOS: La osteoartritis es la más frecuente entre las enfermedades articulares en personas de edad. El objetivo del estudio fue comparar el efecto analgésico de la bupivacaína y de la morfina por vía intra-articular en pacientes portadores de osteoartritis de rodilla. MÉTODO: Fueron evaluados 39 pacientes en estudio doblemente encubierto, divididos de forma aleatoria, en dos grupos: los del G1 (n = 18

  6. Eficacia de las inyecciones de corticosteroides en el tratamiento de la tendinitis del manguito rotador

    OpenAIRE

    Garcés Echevarría, Berezi

    2013-01-01

    El hombro doloroso u omalgia, es una de las principales causas de dolor osteoarticular que se presentan en la práctica clínica cotidiana y a menudo provoca discapacidad funcional considerable. La principal causa de dolor de hombro es la patología inflamatoria o degenerativa del manguito rotador (Milgrom 1995), que puede ser responsable de hasta un 65% de los casos de hombro doloroso del adulto (Veccio 1995). El 12% de todos los contactos paciente-médico a causa de trastornos...

  7. Biologic therapies for chronic inflammatory bowel disease Tratamientos biológicos en la enfermedad inflamatoria crónica intestinal

    Directory of Open Access Journals (Sweden)

    M. P. Martínez-Montiel

    2006-04-01

    Full Text Available Crohn's disease (CD and ulcerative colitis (UC make up the so-called chronic inflammatory bowel disease (IBD. Advances in the understanding of IBD pathophysiologic mechanisms in the last few years have allowed the development of novel therapies such as biologic therapies, which at least theoretically represent a more specific management of this disease with fewer side effects. Currently, the only effective and widely accepted biologic therapy for the treatment of intraluminal, fistulizing CD, both for remission induction and maintenance, is infliximab. The role of other monoclonal antibodies such as adalimumab is not clearly established. It could be deemed an alternative for patients with allergic reactions to infliximab, and for those with lost response because of anti-infliximab antibody development. However, relevant issues such as dosage and administration regimen remain to be established. Anti-integrin α4 therapies, despite encouraging results in phase-3 studies, are still unavailable, as their marketing authorization was held back in view of a number of reports regarding progressive multifocal leukoencephalopathy cases. Immunostimulating therapy may be highly relevant in the near future, as it represents a novel strategy against disease with the inclusion of granulocyte-monocyte colony-stimulating factors. Regarding ulcerative colitis, results from the ACT-1 and ACT-2 studies showed that infliximab is also useful for the management of serious UC flare-ups not responding to standard treatment, which will lead to a revision of therapeutic algorithms, where this drug should be given preference before intravenous cyclosporine. In the next few years, the role of anti-CD3 drugs (vilisilizumab, T-cell inhibiting therapies, and epithelial repair and healing stimulating factors will be established.La enfermedad de Crohn (EC y la colitis ulcerosa (CU constituyen la denominada enfermedad inflamatoria crónica intestinal (EII. Los avances producidos

  8. Relationship between socio-demographic and clinical variables, and health-related quality of life in patients with inflammatory bowel disease Relación entre variables sociodemográficas y clínicas y calidad de vida relacionada con la salud en pacientes con enfermedad inflamatoria intestinal

    Directory of Open Access Journals (Sweden)

    B. López Blanco

    2005-12-01

    Full Text Available Objective: the principal aim of the present study is to evaluate the influence of socio-demographic and clinical variables on health-related quality of life (HRQL in patients with inflammatory bowel disease. Patients and method: this was a cross-sectional study. health-related quality of life was measured with the Inflammatory Bowel Disease Questionnaire (IBDQ. A total of 120 patients, 60 with ulcerative colitis and 60 with Crohn's disease, participated in the study. Results: no significant differences were observed between ulcerative colitis and Crohn's disease patients in IBDQ dimensions. However, a multivariate analysis revealed that sex, type of treatment, extraintestinal symptoms, number of relapses in previous year, satisfaction with surgery, and need for psychological support were related to HRQL. Conclusions: the identification of these variables associated with HRQL in patients with inflammatory bowel disease shows them to be basically non-disease factors. Knowledge of such elements can turn out to be very useful in order to guide future research and modify specific factors in further interventions.Objetivo: el objetivo principal del presente trabajo consiste en evaluar la influencia de las variables sociodemográficas y clínicas en la calidad de vida relacionada con la salud de los pacientes con enfermedad inflamatoria intestinal. Pacientes y método: se trata de un estudio transversal. La calidad de vida relacionada con la salud se investigó utilizando el "Inflammatory Bowel Disease Questionnaire" (IBDQ. Un total de 120 pacientes, 60 con colitis ulcerosa y 60 con enfermedad de Crohn participaron en el estudio. Resultados: no se apreciaron diferencias significativas en la calidad de vida relacionada con la salud en las dimensiones del IBDQ en función de la enfermedad, sin embargo, tras el análisis multivariante, el sexo, el tipo de tratamiento, las manifestaciones extradigestivas, el número de recaídas anual, la satisfacción con

  9. Ángulo óptimo articular y ejercicio: bases y aplicaciones

    Directory of Open Access Journals (Sweden)

    Pablo Antonio Rubio-Sobrino

    2012-09-01

    Full Text Available El ángulo óptimo se refiere a la posición articular en la que se produce el pico máximo de momento de fuerza, dentro de la curva ángulo-momento articular. Este parámetro puede utilizarse para estimar las modificaciones en la curva fuerza-longitud de un grupo muscular. El ángulo óptimo puede ser obtenido a partir de medidas en tests isométricos o dinámicos, y esto debe ser tenido en cuenta a la hora de establecer comparaciones. El ángulo óptimo puede ser modificado tanto de forma aguda como crónica. Los principales factores que lo modifican son la intensidad y el volumen del ejercicio, la longitud muscular, el modo de contracción y la velocidad de contracción. La capacidad para evaluar y modificar el ángulo óptimo puede utilizarse en programas de prevención de lesiones musculares, especialmente en deportes de equipo como el fútbol. Esta revisión analiza y discute los estudios que se encuentran en la bibliografía relacionados con este tema.

  10. Neurophysiological basis for neurogenic-mediated articular cartilage anabolism alteration.

    Science.gov (United States)

    Gouze-Decaris, E; Philippe, L; Minn, A; Haouzi, P; Gillet, P; Netter, P; Terlain, B

    2001-01-01

    This study was designed to investigate the pathways involved in neurogenic-mediated articular cartilage damage triggered by a nonsystemic distant subcutaneous or intra-articular inflammation. The cartilage damage was assessed 24 h after subcutaneous or intra-articular complete Freund's adjuvant (CFA) injection measuring patellar proteoglycan (PG) synthesis (ex vivo [Na(2)(35)SO(4)] incorporation) in 96 Wistar rats. Unilateral subcutaneous or intra-articular injection of CFA induced significant decrease (25-29%) in PG synthesis in both patellae. Chronic administration of capsaicin (50 mg. kg(-1). day(-1) during 4 days), which blunted the normal response of C fiber stimulation, prevented the bilateral significant decrease in cartilage synthesis. Similarly, intrathecal injection of MK-801 (10 nmol/day during 5 days), which blocked the glutamatergic synaptic transmission at the dorsal horn of signal originating in primary afferent C fibers, eliminated the CFA-induced PG synthesis decrease in both patellae. Chemical sympathectomy, induced by guanethidine (12.5 mg. kg(-1). day(-1) during 6 wk), also prevented PG synthesis alteration. Finally, compression of the spinal cord at the T3-T5 level had a similar protective effect on the reduction of [Na(2)(35)SO(4)] incorporation. It is concluded that the signal that triggers articular cartilage synthesis damage induced by a distant local inflammation 1) is transmitted through the afferent C fibers, 2) makes glutamatergic synaptic connections with the preganglionic neurons of the sympathetic system, and 3) involves spinal and supraspinal pathways.

  11. The Functions of BMP3 in Rabbit Articular Cartilage Repair

    Directory of Open Access Journals (Sweden)

    Zhe Zhang

    2015-10-01

    Full Text Available Bone morphogenetic proteins (BMPs play important roles in skeletal development and repair. Previously, we found fibroblast growth factor 2 (FGF2 induced up-regulation of BMP2, 3, 4 in the process of rabbit articular cartilage repair, which resulted in satisfactory repair effects. As BMP2/4 show a clearly positive effect for cartilage repair, we investigated the functions of BMP3 in rabbit articular cartilage repair. In this paper, we find that BMP3 inhibits the repair of partial-thickness defect of articular cartilage in rabbit by inducing the degradation of extracellular matrix, interfering with the survival of chondrocytes surrounding the defect, and directly inhibiting the expression of BMP2 and BMP4. Meanwhile BMP3 suppress the repair of full-thickness cartilage defect by destroying the subchondral bone through modulating the proliferation and differentiation of bone marrow stem cells (BMSCs, and directly increasing the expression of BMP4. Although BMP3 has different functions in the repair of partial and full-thickness defects of articular cartilage in rabbit, the regulation of BMP expression is involved in both of them. Together with our previous findings, we suggest the regulation of the BMP signaling pathway by BMP3 is essential in articular cartilage repair.

  12. Modulación de la respuesta inflamatoria esplácnica en la colestasis microquirúrgica experimental con ketotifén

    OpenAIRE

    Cruz Cidoncha, Arturo

    2013-01-01

    "Introducción". El desarrollo de fibrosis hepática e hipertensión portal en múltiples hepatopatías crónicas de etiología diversa es un proceso multifuncional, mediado por células inflamatorias que, al liberar mediadores fibrogénicos, activan a las células estrelladas y a los miofibroblastos. La administración de ketotifén, un fármaco estabilizador de células cebadas, que inhibe la síntesis y liberación de sus mediadores inflamatorios, en un modelo experimental microquirúrgico de colesta...

  13. Chronic Inflammatory Periodontal Disease in Patients with Human Immunodeficiency Virus. Enfermedad periodontal inflamatoria crónica en pacientes infectados con el virus de inmunodeficiencia humana.

    Directory of Open Access Journals (Sweden)

    Iralys Benítez Guzmán

    2009-07-01

    Full Text Available Background: The Chronic Inflammatory Periodontal Disease is related with multiple risk factors. Those patients with human immunodeficiency virus have higher risk of presenting this disease and it is usually more serious in these cases. Objective: To describe the prevalence of Chronic Inflammatory Periodontal Disease in patients with HIV. Methods: Descriptive, observational, cross-sectional study including patients with HIV in Sancti Spiritus province. The occurrence of the disease was determined after the Periodontics Cuban Standards, and oral hygiene was assessed through the simplified oral hygiene index. Other variables were measured, such as smoking habits, T CD4+ lymphocyte counting and virus load. The independent association of each risk factor with the disease was determined through a logistic regression model. Results: The 56, 5 % of the 154 patients presented Chronic Inflammatory Periodontal Disease; 60 (39.0% gingivitis and 27 (17,5% periodontitis. Gingivitis was associated with poor oral hygiene (OR: 3,71 and periodontitis with smoking habit (OR: 5,20. The severe forms of periodontitis occurred mainly in patients with lymphocyte counting lower than 500 cells/mm3 . Conclusions: The prevalence of Chronic Inflammatory Periodontal Disease in patients with HIV in Sancti Spiritus province is linked to known risk factors such as smoking habits and oral hygiene.Fundamento: La enfermedad periodontal inflamatoria crónica es un trastorno relacionado con diversidad de factores de riesgo. Los pacientes infectados con el virus de inmunodeficiencia humana tienen mayor riesgo para padecerla y en ellos muchas veces se agrava.  Objetivo: Describir la prevalencia de la enfermedad periodontal inflamatoria crónica en pacientes infectados con el virus de inmunodeficiencia humana. Métodos: Estudio observacional

  14. Rehabilitación del sistema vestibular como tratamiento para mejorar el equilibrio en pacientes con esclerosis múltiple. Revisión bibliográfica.

    OpenAIRE

    Gomez Jareño, Iera

    2016-01-01

    Antecedentes: La esclerosis múltiple es la enfermedad inflamatoria más frecuente del sistema nervioso central, y la segunda causa de discapacidad neurológica en adultos jóvenes. En este tipo de pacientes, el vértigo y la falta de equilibrio debida a alteraciones del sistema vestibular son síntomas muy comunes. Se han empleado distintos programas de entrenamiento del equilibrio entre los cuales se encuentra la rehabilitación vestibular. Objetivos: El objetivo de esta revisión es...

  15. REGENERATION OF ARTICULAR CARTILAGE UNDER THE IMPLANTATION OF BONE MATRIX

    Directory of Open Access Journals (Sweden)

    Yuri M. Iryanov, Nikolay A. Kiryanov, Olga V. Dyuriagina , Tatiana Yu. Karaseva, Evgenii A. Karasev

    2015-07-01

    Full Text Available Background: The damage or loss of articular cartilage is costly medical problem. The purpose of this work – morphological analysis of reparative chondrogenesis when implanted in the area of the knee joint cartilage of granulated mineralized bone matrix. Material and Methods: The characteristic features of the knee cartilage regeneration studied experimentally in pubertal Wistar rats after modeling a marginal perforated defect and implantation of granulated mineralized bone matrix obtained according to original technology without heat and demineralizing processing into the injury zone. Results: This biomaterial established to have pronounced chondro- and osteoinductive properties, and to provide prolonged activation of reparative process, accelerated organotypical remodeling and restoration of the articular cartilage injured. Conclusion: The data obtained demonstrate the efficacy of МВМ in clinical practice for the treatment of diseases and injuries of the articular cartilage.

  16. Experimental articular cartilage repair in the Göttingen minipig

    DEFF Research Database (Denmark)

    Christensen, Bjørn Borsøe; Foldager, Casper Bindzus; Olesen, Morten Lykke;

    2015-01-01

    BACKGROUND: A gold standard treatment for articular cartilage injuries is yet to be found, and a cost-effective and predictable large animal model is needed to bridge the gap between in vitro studies and clinical studies. Ideally, the animal model should allow for testing of clinically relevant...... treatments and the biological response should be reproducible and comparable to humans. This allows for a reliable translation of results to clinical studies.This study aimed at verifying the Göttingen minipig as a pre-clinical model for articular cartilage repair by testing existing clinical cartilage...

  17. Intra-Articular Osteotomy for Distal Humerus Malunion

    Directory of Open Access Journals (Sweden)

    René K. Marti

    2009-01-01

    Full Text Available Intra-articular osteotomy is considered in the rare case of malunion after a fracture of the distal humerus to restore humeral alignment and gain a functional arc of elbow motion. Traumatic and iatrogenic disruption of the limited blood flow to the distal end of the humerus resulting in avascular necrosis of capitellum or trochlea is a major pitfall of the this technically challenging procedure. Two cases are presented which illustrate the potential problems of intra-articular osteotomy for malunion of the distal humerus.

  18. EFECTO DE UN PROGRAMA DE HIDROQUINESIA Y ACONDICIONAMIENTO FÍSICO EN LA MOVILIDAD ARTICULAR DE ADULTAS MAYORES

    OpenAIRE

    Cinthya Campos Salazar; Luis Solano Mora

    2001-01-01

    El propósito de este estudio fue determinar el efecto de un programa combinado de hidroquinesia y acondicionamiento físico y otro de acondicionamiento físico solamente en la movilidad articular en las caderas de un grupo de adultas mayores. Sesenta y tres sujetos (edad promedio = 66.06 años, S.D. ±6.77) fueron asignados a los grupos control, hidroterapia y acondicionamiento físico y solo acondicionamiento físico. La duración del programa fue de una hora por sesión, dos veces a la semana duran...

  19. Nutrición artificial en la insuficiencia intestinal: síndrome de intestino corto: Enfermedad inflamatoria intestinal Artificial nutrition in intestinal failure: short bowel syndrome. Intestinal inflammatory disease

    Directory of Open Access Journals (Sweden)

    T. Grau Carmona

    2005-06-01

    Full Text Available La resección intestinal amplia produce suficientes alteraciones como para requerir soporte nutricional especializado. Las medidas básicas de tratamiento, especial-mente en la fase aguda tras la resección intestinal o en presencia de complicaciones graves sobre pacientes con intestino corto, incluyen la repleción de fluidos y electro-litos y la instauración de soporte nutricional con el fin de prevenir la malnutrición. La nutrición enteral es el principal factor estimulador de la adaptación del intestino remanente. No obstante, su aplicación presenta dificultades en las fases agudas, por lo que los pacientes deben ser tratados frecuentemente con nutrición parenteral. La presencia de desnutrición puede ser también de importancia en los pacientes con enfermedad inflamatoria intestinal. El soporte nutricional está indicado en estos casos como tratamiento primario de la enfermedad, como tratamiento de la desnutrición o como tratamiento perioperatorio en los pacientes que requieren cirugía. A pesar de la patología digestiva, existen datos para recomendar la nutrición enteral como método inicial para el aporte de nutrientes en los pacientes que lo precisen.Large intestinal resection produces a sufficient number of impairments as to require specialized nutritional support. Basic treatment measures, especially during the acute phase after intestinal resection or in the presence of severe complications in patients with short bowel syndrome, include fluid and electrolytes reposition and nutritional support implementation in order to prevent hyponutrition. Enteral nutrition is the main stimulating factor for adaptation of the remaining bowel. However, its application has some difficulties during the acute phase, and thus patients must be frequently treated with parenteral nutrition. The presence of hyponutrition may be also important in patients with intestinal inflammatory disease. Nutritional support is indicated in these cases as the

  20. Hallazgo de una leucorrea vaginal de carácter no inflamatoria en hembras bovinas. I. Examen macroscópico y microscópico (Finding of a vaginal leucorrhea of non-inflammatory character in bovine females. I. Macroscopic and microscopic examination

    Directory of Open Access Journals (Sweden)

    Luis O. Alba Gómez,

    2005-10-01

    Full Text Available Con el objetivo de demostrar la existencia de una leucorrea vaginal no inflamatoria en hembras bovinas, se examinaron macroscópicamente los órganos genitales de 350 novillas y 800 vacas Cebú comercial y mestizas Holstein x Cebú sacrificadas en el matadero. Se colectaron secreciones leucorréicas en las vaginas o cuernos uterinos del 12 y 20% de las novillas y vacas respectivamente. Ninguno de los órganos genitales de estos animales mostraron signos de inflamación en sus mucosas. El examen histológico se realizó en 80 muestras de vagina y de cuernos uterinos leucorréicos y solamente el 6,3% de los cortes histológicos de vaginas y el 8,8% de los de úteros presentaron lesiones microscópicas leves. El pH vaginal promedió 6,85  0,2. No se encontraron diferencias en el espectro electroforético entre las secreciones mucosas y las leucorréicas. Tampoco se encontraron células inflamatorias en los frotis teñidos. Los resultados indican que las secreciones leucorréicas observadas no son verdaderos exudados, sino secreciones mucosas modificadas que no tienen un origen inflamatorio. With the objective of demonstrating the existence of a non-inflammatory vaginal leucorrhea in bovine females, the genital organs of 350 heifers and 800 Zebu cows and of the crossing Holstein x Zebu, slaughterhouse, were examined macroscopically. Mucopurulent and purulent exudates were collected in vaginas or uterine horns of the 12 and 20% of heifers and cows respectively. In none of the genital organs of these animals were observed inflammation signs in their mucous membranes. For the histological examination 80 samples of those vagina and uterine horns were used; only 6.3% of the histological preparations from vagina and 8.8% from the uterus presented slight microscopic lesions. The vaginal pH averaged 6,85  0,2. There were not differences in the electrophoretic spectrum between the mucous secretions and the leucorrheic one. Inflammatory cells in the

  1. Chondrogenic potential of articular chondrocytes depends on their original location

    NARCIS (Netherlands)

    Bekkers, Joris E J; Saris, Daniel B F; Tsuchida, Anika Iris; van Rijen, Mattie H P; Dhert, Wouter J A; Creemers, Laura B

    2014-01-01

    OBJECTIVE: This study aimed to investigate the regenerative capacity of chondrocytes derived from debrided defect cartilage and healthy cartilage from different regions in the joint to determine the best cell source for regenerative cartilage therapies. METHODS: Articular cartilage was obtained from

  2. Clinical Outcome Scoring of Intra-articular Calcaneal Fractures

    NARCIS (Netherlands)

    T. Schepers (Tim); M.J. Heetveld (Martin); P.G.H. Mulder (Paul); P. Patka (Peter)

    2008-01-01

    textabstractOutcome reporting of intra-articular calcaneal fractures is inconsistent. This study aimed to identify the most cited outcome scores in the literature and to analyze their reliability and validity. A systematic literature search identified 34 different outcome scores. The most cited outc

  3. The epidemiology of extra-articular manifestations in ankylosing spondylitis

    DEFF Research Database (Denmark)

    Stolwijk, Carmen; Essers, Ivette; van Tubergen, Astrid

    2015-01-01

    OBJECTIVE: To assess the incidence and risks of common extra-articular manifestations (EAMs), that is, acute anterior uveitis (AAU), psoriasis and inflammatory bowel disease (IBD), in patients with ankylosing spondylitis (AS) compared with population-based controls. METHODS: All incident patients...

  4. Early micromovement of the Articular Surface Replacement (ASR) femoral component

    DEFF Research Database (Denmark)

    Penny, J O; Ding, M; Varmarken, J E;

    2012-01-01

    Radiostereometric analysis (RSA) can detect early micromovement in unstable implant designs which are likely subsequently to have a high failure rate. In 2010, the Articular Surface Replacement (ASR) was withdrawn because of a high failure rate. In 19 ASR femoral components, the mean micromovemen...

  5. Computational aspects in mechanical modeling of the articular cartilage tissue.

    Science.gov (United States)

    Mohammadi, Hadi; Mequanint, Kibret; Herzog, Walter

    2013-04-01

    This review focuses on the modeling of articular cartilage (at the tissue level), chondrocyte mechanobiology (at the cell level) and a combination of both in a multiscale computation scheme. The primary objective is to evaluate the advantages and disadvantages of conventional models implemented to study the mechanics of the articular cartilage tissue and chondrocytes. From monophasic material models as the simplest form to more complicated multiscale theories, these approaches have been frequently used to model articular cartilage and have contributed significantly to modeling joint mechanics, addressing and resolving numerous issues regarding cartilage mechanics and function. It should be noted that attentiveness is important when using different modeling approaches, as the choice of the model limits the applications available. In this review, we discuss the conventional models applicable to some of the mechanical aspects of articular cartilage such as lubrication, swelling pressure and chondrocyte mechanics and address some of the issues associated with the current modeling approaches. We then suggest future pathways for a more realistic modeling strategy as applied for the simulation of the mechanics of the cartilage tissue using multiscale and parallelized finite element method.

  6. Evidence for a negative Pasteur effect in articular cartilage.

    Science.gov (United States)

    Lee, R B; Urban, J P

    1997-01-01

    Uptake of external glucose and production of lactate were measured in freshly-excised bovine articular cartilage under O2 concentrations ranging from 21% (air) to zero (N2-bubbled). Anoxia (O2 concentration Pasteur effect in bovine articular cartilage. Anoxia also suppressed glycolysis in articular cartilage from horse, pig and sheep. Inhibitors acting on the glycolytic pathway (2-deoxy-D-glucose, iodoacetamide or fluoride) strongly decreased aerobic lactate production and ATP concentration, consistent with the belief that articular cartilage obtains its principal supply of ATP from substrate-level phosphorylation in glycolysis. Azide or cyanide lowered the ATP concentration in aerobic cartilage to approximately the same extent as did anoxia but, because glycolysis (lactate production) was also inhibited by these treatments, the importance of any mitochondrial ATP production could not be assessed. A negative Pasteur effect would make chondrocytes particularly liable to suffer a shortage of energy under anoxic conditions. Incorporation of [35S]sulphate into proteoglycan was severely curtailed by treatments, such as anoxia, which decreased the intracellular concentration of ATP.

  7. Surgery for extra-articular trismus : a systematic review

    NARCIS (Netherlands)

    Bouman, M A; Dijkstra, P U; Reintsema, H; Roodenburg, J L N; Werker, P M N

    2015-01-01

    The aim of this systematic review was to identify operations that are used to improve mouth opening in patients with extra-articular trismus (caused by cancer and its treatment, oral submucous fibrosis, or noma) and to find out if they work. We searched the electronic databases PubMed, Embase, Cinah

  8. Surgery for extra-articular trismus : a systematic review

    NARCIS (Netherlands)

    Bouman, M. A.; Dijkstra, P. U.; Reintsema, H.; Roodenburg, J. L. N.; Werkera, P. M. N.

    2016-01-01

    The aim of this systematic review was to identify operations that are used to improve mouth opening in patients with extra-articular trismus (caused by cancer and its treatment, oral submucous fibrosis, or noma) and to find out if they work. We searched the electronic databases PubMed, Embase, Cinah

  9. Doxycycline inhibits collagen synthesis by differentiated articular chondrocytes.

    NARCIS (Netherlands)

    TeKoppele, J.M.; Beekman, B.; Verzijl, N.; Koopman, J.L.; Groot, J. de; Bank, R.A.

    1998-01-01

    Doxycycline (DOX) profoundly inhibited collagen synthesis by differentiated articular chondrocytes. At 25 microM, the rate of collagen synthesis was suppressed by more than 50% without affecting cell proliferation (DNA levels) and general protein synthesis (35S-Met and 35S-Cys incorporation). Steady

  10. La membrana amniótica humana : caracterización de las células madre y su aplicación en terapia celular para reparar lesiones de cartílago articular humano

    OpenAIRE

    Muiños López, Emma

    2011-01-01

    [Resumen] La capacidad de reparación del cartílago articular es muy limitada, debidoprincipalmente a que es un tejido avascular. Actualmente no existentratamientos farmacológicos eficaces para curar la artrosis (osteoarthritis, OA),aunque algunos fármacos podrían retardar su progresión. La mayoría de losesfuerzos realizados hasta la actualidad con la finalidad de reparar una lesiónde cartílago articular van encaminados a superar las limitaciones que poseeeste tejido para cicatrizar las lesion...

  11. The Effectiveness of Ultrasound-Guided Steroid Injection for Femoroacetabular Impingement: A Comparison between the Extra-Articular and Intra-Articular Approaches

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Chang Ho; Lee, Joon Woo [Dept. of Radiology, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of)

    2013-03-15

    To assess the effectiveness of pain control using ultrasound-guided steroid injection by the extra-articular and intra-articular approaches to femoroacetabular impingement patients. From September through December 2010, 18 patients with clinical suspicion of femoroacetabular impingement syndrome underwent ultrasound-guided steroid and local anesthetics injection: a total of 20 cases, including 16 cases of ipsilateral and 2 cases of bilateral injection. Extra-articular or intra-articular approach was selected for each patient, randomly and alternately. Nine cases were performed by extra-articular approach and 11 cases were performed by intra-articular approach. Every patient was observed in the outpatient clinic and visual analogue scale (VAS) was taken and compared before and after the procedure in all patients. Pre-injection average VAS value of extra-articular approached cases was 5.22 {+-} 1.99 and post-injection average VAS value was 4.11 {+-} 1.96, which is statistically insignificant (p < 0.156). The average VAS value of intra-articular approached cases was decreased from 5.72 {+-} 2.15 to 2.91 {+-} 2.30 after injection, which is statistically significant (p < 0.006). Ultrasound guided intra-articular approached steroid and local anesthetics injection could be effective in controlling pain for patients with femoroacetabular impingement syndrome.

  12. Modificaciones de la amplitud articular de tobillo durante la marcha en niños afectos de PCI y pie equino tratados con TBA

    OpenAIRE

    Barceló, O.; Guijarro, I.; García-Muro, F.; Busturia, I.; García, P; Pascual-Pascual, I.; García-Rama, L.; Vergara, F.

    2001-01-01

    El objetivo de este estudio fue comprobar el efecto de la TBA (BOTOXâ) en la amplitud articular del tobillo durante la marcha en pacientes afectos de PCI. La muestra estuvo formada por 9 niños con una media de 6 años de edad distribuyéndose en 4 grupos de estudio: control, hemipléjico, dipléjico I y dipléjico II. Las variables cuantificadas fueron la máxima flexión dorsal y plantar realizadas durante la marcha (calzados y descalzos) así como los porcentajes del CM en el que se ...

  13. Rotura aguda completa del ligamento colateral metacarpo-falángico radial del pulgar: una lesión grave infrecuente

    OpenAIRE

    Pellicer García, V.; Gutiérrez Carbonell, Pedro; Moril Peñalver, L.

    2012-01-01

    El ligamento colateral radial es el principal estabilizador articular contra las fuerzas de estrés en aducción de la articulación metacarpofalángica del pulgar. Esta lesión infrecuente, pasa a menudo desapercibida, desarrollándose una inestabilidad articular sintomática y, posteriormente, una artrosis secundaria. Aunque tradicionalmente se ha recomendado el tratamiento conservador de estas lesiones, estudios recientes han documentado mejores resultados funcionales cuando se realiza su repa...

  14. Eficacia del entrenamiento excéntrico en tendinopatía aquílea

    OpenAIRE

    Martínez Martínez, Daniel

    2013-01-01

    La tendinopatía aquilea se produce cuando se forman pequeños desgarros en las fibras que conforman el tendón. Independientemente de si la lesión es inflamatoria o degenerativa, o si el asiento de la lesión está en la inserción o en el cuerpo del tendón, un alto porcentaje de personas, hasta un 60%, que presenta una Tendinopatía de Aquiles tiene problemas de apoyo podal o de mala alineación de la extremidad inferior. No se sabe cual es mejor tratamiento para ella. Objetivo...

  15. Estudio de la fisiopatología del sistema inmune en la enfermedad de Fabry

    OpenAIRE

    2013-01-01

    La hipótesis que proponemos y evaluamos a lo largo de este trabajo de tesis está centrada en la existencia de un estado proinflamatorio en la Enfermedad de Fabry, que involucra células del sistema inmune y es causado por la acumulación de globotriaosilceramida (Gb3) a nivel lisosomal. Esos depósitos de Gb3 generarían el desencadenamiento de mecanismos patogénicos que producen un aumento de apoptosis y una respuesta inmune inflamatoria. Estas respuestas serían las responsables de alteraciones ...

  16. EFECTO DE UN PROGRAMA DE HIDROQUINESIA Y ACONDICIONAMIENTO FÍSICO EN LA MOVILIDAD ARTICULAR DE ADULTAS MAYORES

    Directory of Open Access Journals (Sweden)

    Cinthya Campos Salazar

    2001-12-01

    Full Text Available El propósito de este estudio fue determinar el efecto de un programa combinado de hidroquinesia y acondicionamiento físico y otro de acondicionamiento físico solamente en la movilidad articular en las caderas de un grupo de adultas mayores. Sesenta y tres sujetos (edad promedio = 66.06 años, S.D. ±6.77 fueron asignados a los grupos control, hidroterapia y acondicionamiento físico y solo acondicionamiento físico. La duración del programa fue de una hora por sesión, dos veces a la semana durante 16 semanas. Se aplicó un pretest y un postest de movilidad articular para medir la movilidad global de las caderas (flexión, abducción, aducción, rotación interna y externa. Las variables independientes fueron lado izquierdo y derecho vs. grupos de tratamiento. Los resultados indicaron lo siguiente: el grupo control no varío la movilidad articular en las mediciones de flexión, rotación interna y externa (p>0.05 mientras que para la mediciones de abducción y aducción disminuyó significativamente (p<0.05. En cuanto a los grupos de tratamiento, el grupo que realizó el programa combinado de hidroquinesia y acondicionamiento físico aumentó significativamente (p<0.05 la movilidad articular a nivel de flexión, abducción y aducción, en tanto el grupo que realizó el programa de acondicionamiento físico solamente, mejoró significativamente (p<0.05 en flexión, abducción, aducción, rotación interna como externa. En conclusión se recomienda la práctica de actividad física tanto en el agua como fuera de ella, pues mejora los rangos de movilidad articular en cadera, a nivel global en personas adultas mayores.

  17. Dano muscular: resposta inflamatória sistêmica após ações excêntricas máximas Daño muscular: respuesta inflamatoria sistémica después de acciones excéntricas máximas Muscle damage: systemic inflammatory response after maximal eccentric actions

    Directory of Open Access Journals (Sweden)

    Ricardo Paes de Barros Berton

    2012-09-01

    Full Text Available O objetivo deste estudo foi analisar a resposta inflamatória induzida por grande número de ações excêntricas (AE máximas realizadas pelos flexores do cotovelo. Participaram do estudo nove homens jovens, que realizaram 35 séries de seis AE nos flexores de cotovelo, com intervalo de um minuto, utilizando um dinamômetro isocinético em uma velocidade de 210º.s-1. As variáveis mensuradas foram: a contração isométrica voluntaria máxima (CIVM, a amplitude de movimento (AM, a dor muscular de inicio tardio (DMIT, a interleucina-6 (IL-6 e o fator de necrose tumoral alfa (TNF-α. Alterações significantes foram observadas para os marcadores indiretos de dano muscular (CIVM, AM e DMIT, entretanto não houve modificações para os marcadores inflamatórios (IL-6 e TNF-α. Em conclusão, os resultados demonstraram que mesmo com alterações nos marcadores indiretos de dano muscular após a realização de um grande número de AE não foram observadas alterações na resposta inflamatória sistêmica.El objetivo del presente estudio fue analizar la magnitud de la respuesta inflamatoria inducida por un gran número de acciones excéntricas (AE de los flexores del codo. Han participado del estudio nueve jóvenes que llevaron a cabo 35 series de seis AE de los flexores del codo, con un intervalo de un minuto, utilizando un dinamómetro isocinético a 210º.s-1. Fueran mensurados la máxima contracción voluntaria isométrica (CIVM, la amplitud de movimiento (AM, el dolor muscular de aparición tardía (DMIT, la interleucina 6 (IL-6 y el factor de necrosis tumoral alfa (TNF-α. Se observaron cambios significativos para los marcadores de daño muscular (CIVM, AM y DMIT, sin embargo, no hubo cambios en los marcadores de inflamación IL-6 y TNF-α. En conclusión, los resultados indican que mismo con un gran número de AE y cambios en los marcadores indirectos de daño muscular, no se observaron cambios en la respuesta inflamatoria sist

  18. One intra-articular injection of hyaluronan prevents cell death and improves cell metabolism in a model of injured articular cartilage in the rabbit

    NARCIS (Netherlands)

    Jansen, Edwin J. P.; Ernans, Pieter J.; Douw, Conny M.; Guidemond, Nick A.; Van Rhijn, Lodewijk W.; Bulstra, Sjoerd K.; Kuijer, Roell

    2008-01-01

    The purpose of this study was to determine the effect of one intra-articular injection of hyaluronan on chondrocyte death and metabolism in injured cartilage. Twenty-three 6-month-old rabbits received partial-thickness articular cartilage defects created on each medial femoral condyle. In order to e

  19. La influencia de la superficie articular y la membrana sinovial en la evolución de pacientes afectos por bloqueo crónico de la articulación temporomandibular tratados mediante artroscopia Influence of the joint surface and the synovial membrane on the evolution of patients affected by chronic temporomandibular joint block who were treated with arthroscopic surgery

    OpenAIRE

    R. González-García; J. Sastre-Pérez; F.J. Rodríguez-Campo

    2010-01-01

    Introducción: Se ha referido la artroscopia de la articulación temporomandibular (ATM) como una técnica efectiva en el tratamiento del bloqueo crónico (BC) articular. El propósito del presente estudio es evaluar si el estado de la superficie articular y la membrana sinovial directamente visualizados por artroscopia pueden determinar el resultado posoperatorio de pacientes afectos por BC de la ATM. Pacientes y método: Doscientos cincuenta y siete de 500 pacientes (344 articulaciones) cumpliero...

  20. Epidemiology of extra-articular manifestations in rheumatoid arthritis.

    Science.gov (United States)

    Turesson, C; Jacobsson, L T H

    2004-01-01

    Extra-articular RA (ExRA) includes a wide variety of disease manifestations. Although rheumatologists in general are aware that such events are clinically important, the heterogeneity of available data, including discrepancies in case definitions, has complicated constructive discussions on this aspect of the RA disease phenotype. In recent years, there has been a growing recognition of the importance of co-morbidity in patients with RA. ExRA manifestations are not uncommon, explain excess mortality in RA and are predicted by smoking and autoantibodies. Further studies of the mechanisms underlying these associations are likely to be important in improving our understanding of the systemic nature of RA. This article discusses the methodological issues involved in the study of ExRA manifestations, presents suggested criteria that have been used in clinical studies, and reviews important surveys of the epidemiology of extra-articular RA.

  1. Caracterización de las acciones protectoras del ácido oleanólico en modelos experimentales de patologías con base inflamatoria

    OpenAIRE

    Pereira Córdova Marcos, Cláudia Manuela

    2015-01-01

    La Esclerosis Múltiple y la Miocarditis son dos enfermedades autoinmunes que se deben a la alteración en la respuesta inmune donde el organismo no reconoce el propio de lo extraño. La Conjuntivitis Alérgica se debe a alteraciones de la respuesta inmune asociada a reacciones de hipersensibilidad y es una respuesta inmune exagerada a un agente inocuo. El ácido oleanólico (AO) es un compuesto natural que se encuentra en numerosas plantas entre las cuales el olivo y presenta propiedades: cardiopr...

  2. Frecuencia de anticuerpos para diagnóstico de enfermedad celíaca en pacientes con enfermedades del tejido conectivo y artropatías inflamatorias

    OpenAIRE

    Rodríguez,Graciela Rita; Zazzetti, Federico; da Representaçao,Silvia Raquel; Lencina,María Verónica; Barreira,Juan Carlos; Álvarez,Karina Elizabeth

    2014-01-01

    Background: The detection of anti-transglutaminase IgA (tTG) and anti-endomysial (EMA) is used for screening of celiac disease (CD) with a sensitivity and specificity of 90 and 99% respectively. There is an association between CD and connective tissue diseases (CTD). Aim: To report the frequency of IgA tTG and EMA in patients with a definite diagnosis of CTD and inflammatory arthropathies (IA). Material and Methods: One hundred forty nine patients, aged 19 to 86 years (133 females) with CTD a...

  3. Spontaneous Redifferentiation of Dedifferentiated Human Articular Chondrocytes on Hydrogel Surfaces

    OpenAIRE

    2010-01-01

    Chondrocytes rapidly dedifferentiate into a more fibroblastic phenotype on a two-dimensional polystyrene substratum. This impedes fundamental research on these cells as well as their clinical application. This study investigated the redifferentiation behavior of dedifferentiated chondrocytes on a hydrogel substratum. Dedifferentiated normal human articular chondrocyte–knee (NHAC-kn) cells were released from the sixth-passage monolayer cultured on a polystyrene surface. These cells were then s...

  4. Parasitosis intestinal extrema en la infancia previa al desarrollo de enfermedades reumáticas inflamatorias/autoinmunes

    OpenAIRE

    F. Javier Jiménez-Balderas; Adolfo Camargo-Coronel; Talavera, Juan O; José Gutiérrez; Abraham Zonana-Nacach; Ernesto A. Jiménez-Balderas

    2008-01-01

    Objetivo. Investigar la asociación del antecedente de parasitosis intestinal extrema (PIE) durante la infancia enpacientes ahora adultos con enfermedades reumáticas/ autoinmunes (ERAI). Métodos. Se estudiaron 54 pacientes consecutivos con ERAI, (27 con espondilitis anquilosante 9 con artritis reumatoide, 19 con lupus eritematoso sistémico) y 54 controles sanos; 27 hombres y 27 mujeres. Todos los sujetos tenían padres que informaran de eventos PIE durante la infancia, previos al inicio de la E...

  5. The biochemical content of articular cartilage: an original MRI approach.

    Science.gov (United States)

    Loeuille, Damien; Olivier, Pierre; Watrin, Astrid; Grossin, Laurent; Gonord, Patrick; Guillot, Geneviève; Etienne, Stéphanie; Blum, Alain; Netter, Patrick; Gillet, Pierre

    2002-01-01

    The MR aspect of articular cartilage, that reflects the interactions between protons and macromolecular constituents, is affected by the intrinsic tissue structure (water content, the content of matrix constituents, collagen network organization), imager characteristics, and acquisition parameters. On the T1-weighted sequences, the bovine articular cartilage appears as an homogeneous tissue in high signal intensity, whatever the age of animals considered, whereas on the T2-weighted sequences, the articular bovine cartilage presents variations of its imaging pattern (laminar appearance) well correlated to the variations of its histological and biochemical structure. The T2 relaxation time measurement (T2 mapping), which reflects quantitatively the signal intensity variations observed on T2 weighted sequences, is a way to evaluate more precisely the modifications of cartilage structure during the aging and maturation processes (rat's study). This technique so far confined to experimental micro-imagers is now developed on clinical imagers. Consequently, it may permit to depict the early stages of osteoarthritic disease (OA) or to evaluate the chondroprotective effect of drugs.

  6. Sonographic evaluation of femoral articular cartilage in the knee

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Sung Hwan [College of Medicine, Hallym University, Seoul (Korea, Republic of); Kong Keun Young; Chung, Hye Won; Choi, Young Ho; Song, Yeong Wook; Kang, Heung Sik [College of Medicine and the Institute of Radiation Medicine, Seoul National University, Seoul (Korea, Republic of)

    2000-06-01

    To investigate the usefulness of sonography for the evaluation of osteoarthritic articular cartilage. Ten asymptomatic volunteers and 20 patients with osteoarthritis of the knee underwent sonographic evaluation. For this, the knee was maintained of full flexion in order to expose the deep portion of femoral condylar cartilage. Both transverse and longitudinal scans were obtained in standardized planes. Sonographic images of the articular cartilages were analyzed in terms of surface sharpness, echogenicity and thickness, along with associated bone changes. Normal cartilages showed a clearly-defined surface, homogeneously low echogenicity and regular thickness. Among 20 patients, the findings for medial and lateral condyles, respectively, were as follows: poorly defined cartilage surface, 16 (80%) and ten (50%); increased echogenicity of cartilage, 17 (85%) and 16 (80%); cartilage thinning, 16 (80%) and 14 (70%) (two medial condyles demonstrated obvious cartilage thickening); the presence of thick subchondral hyperechoic bands, five (25%) and four (20%); the presence of osteophytes, 13 (65%) and 12 (60%). Sonography is a convenient and accurate modality for the evaluation of femoral articular cartilage. In particular, it can be useful for detecting early degenerative cartilaginous change and for studying such change during clinical follow-up. (author)

  7. Ultrasonic quantitation of superficial degradation of articular cartilage.

    Science.gov (United States)

    Saarakkala, Simo; Töyräs, Juha; Hirvonen, Jani; Laasanen, Mikko S; Lappalainen, Reijo; Jurvelin, Jukka S

    2004-06-01

    Ultrasound (US) has been suggested as a means for the quantitative detection of early osteoarthrotic changes in articular cartilage. In this study, the ability of quantitative US 2-D imaging (20 MHz) to reveal superficial changes in bovine articular cartilage after mechanical or enzymatic degradation was investigated in vitro. Mechanical degradation was induced by grinding samples against an emery paper with the grain size of 250 microm, 106 microm, 45 microm or 23 microm. For enzymatic degradation, samples were digested with collagenase, trypsin or chondroitinase ABC. Variations of the US reflection coefficient induced by the degradation were investigated. Furthermore, two novel parameters, the US roughness index (URI) and the spatial variation of the US reflection coefficient (SVR), were established to quantitate the integrity of the cartilage surface. Statistically significant decreases (p < 0.05) in US reflection coefficient were observed after mechanical degradations or enzymatic digestion with collagenase. Increases (p < 0.05) in URI were also revealed after these treatments. We conclude that quantitative US imaging may be used to detect collagen disruption and increased roughness in the articular surface. These structural damages are typical of early osteoarthrosis.

  8. Photogrammetric analysis of the articular surface of the distal radius.

    Science.gov (United States)

    Ege, A; Seker, D Z; Tuncay, I; Duran, Z

    2004-01-01

    Three-dimensional measurements made using photogrammetry have recently gained popularity with the development of real-time detection facilities and up-to-date equipment. The modelling of human bones presents a particular challenge as the measurements required are difficult to obtain, especially from uneven surfaces. In this study, the articular surfaces of 12 radius bones were evaluated using photogrammetry to obtain three-dimensional coordinates of certain points. Morphometric characteristics of the digital topography of the articular surface were analysed using three-dimensional data from more than 200 points for each specimen. The coronal plane curve, from the tip of the styloid process to the centre of the distal radioulnar articular notch, was found to be similar to the fourth degree polynomial function. A mathematical expression representing the sagittal curve passing through scapholunate border could not be found. Close-range photogrammetry is a safe and precise technique that can provide reliable, reproducible and accurate data for evaluating complex morphological surfaces.

  9. Influência de diferentes ângulos articulares obtidos na posição inicial do exercício pressão de pernas e final do exercício puxada frontal sobre os valores de 1RM Influencia en los diferentes ángulos articulares obtenidos en la posición inicial del ejercicio de presión de piernas y al final del ejercicio de puje frontal sobre los valores de 1RM The influence of different joint angles obtained in the starting position of leg press exercise and at the end of the frontal pull exercise on the values of 1RM

    Directory of Open Access Journals (Sweden)

    João Augusto Reis de Moura

    2004-08-01

    Full Text Available O teste de uma repetição máxima (1RM tem sido aplicado sobre várias circunstâncias e em diversos objetivos, sendo que variáveis potencialmente influenciadoras deste teste têm sido constantemente estudadas. Este estudo buscou avaliar a influência de diferentes ângulos na posição inicial de execução dos exercícios pressão de pernas e posição final do exercício puxada frontal sobre os resultados de 1RM. Para tal foram mensurados no teste de 1RM dos exercícios pressão de pernas e puxada frontal 20 sujeitos voluntários do sexo masculino (médias de idade 24,5 anos, estatura 1,75 metros e massa corporal de 72,0kg. Após consentimento de participação e a adaptação ao treinamento resistido com pesos, foi aplicado o teste de 1RM no exercício pressão de pernas em três diferentes ângulos de testagem na posição inicial (80º, 90º e 100º de flexão do joelho e também no exercício puxada frontal posição final (60º, 70º e 80º de flexão do cotovelo, sendo que cada ângulo foi testado em dias diferentes, porém com os dois exercícios. Os resultados indicam que as médias de 1RM para o exercício pressão de pernas são estatisticamente diferentes (F = 30,199; p = 0,000 entre si (post hoc de Tukey. Já para o exercício puxada frontal, embora existam diferenças, estas não foram estatisticamente significativas (F = 1,330; p = 0,281. Conclui-se que diferentes técnicas de execução dos exercícios que envolvam angulações diversas, principalmente nas posições iniciais destes, devem ser rigorosamente controladas, pois podem afetar a quilagem levantada.El test de Repetición Máxima (1RM ha sido aplicado en varias circunstancias y en diversos objetivos siendo que variable potencialmente influyentes en este test vienen siendo constantemente estudiadas. Este estudio buscó evaluar la influencia de diferentes ángulos en la posición final del ejercicio de presión de piernas y de puje frontal sobre los resultados de 1RM

  10. En bloc joystick reduction of a comminuted intra-articular distal radius fracture: a technical trick.

    Science.gov (United States)

    Siegall, Evan; Ziran, Bruce

    2014-08-01

    A patient with a 1-month-old intra-articular distal radius fracture (treated closed in a splint) presented with an unacceptable degree of pain and stiffness caused by shortening and dorsal angulation of the distal radius. The fracture was comminuted with 4 or 5 distinct fragments, several involving the articular surface. Surgical correction was attempted. During the procedure, it was noted that, though the distal radius was shortened and angulated, there was actually acceptable congruity of the articular surface itself, despite the intra-articular nature of the fracture. Bone quality was poor and healing incomplete. Thus, we were concerned the currently congruous articular surface would fall apart with manipulation. Given this situation, we used a unique scaffolding technique with Kirschner wires placed in perpendicular fashion to both hold the articular surface intact and manipulate it en bloc. This technique is a simple way to turn a complex fracture into an easily reduced 2-part fracture.

  11. Intra-articular osteoid osteoma at the femoral trochlea treated with osteochondral autograft transplantation

    Science.gov (United States)

    Leeman, Joshua J; Motamedi, Daria; Wildman-Tobriner, Ben; O’Donnell, Richard J; Link, Thomas M

    2016-01-01

    We present the case of an intra-articular osteoid osteoma at the femoral trochlea. Intra-articular osteoid osteoma can present a diagnostic challenge both clinically and with imaging because it presents differently from the classic cortical osteoid osteoma. Given the lesion’s proximity to overlying cartilage, the patient underwent resection of the lesion with osteochondral autograft transplantation at the surgical defect. A comprehensive literature review and discussion of intra-articular osteoma will be provided. PMID:27761182

  12. Effects of Articular Cartilage Constituents on Phosphotungstic Acid Enhanced Micro-Computed Tomography

    Science.gov (United States)

    Karhula, Sakari S.; Finnilä, Mikko A.; Lammi, Mikko J.; Ylärinne, Janne H.; Kauppinen, Sami; Rieppo, Lassi; Pritzker, Kenneth P. H.; Nieminen, Heikki J.; Saarakkala, Simo

    2017-01-01

    Contrast-enhanced micro-computed tomography (CEμCT) with phosphotungstic acid (PTA) has shown potential for detecting collagen distribution of articular cartilage. However, the selectivity of the PTA staining to articular cartilage constituents remains to be elucidated. The aim of this study was to investigate the dependence of PTA for the collagen content in bovine articular cartilage. Adjacent bovine articular cartilage samples were treated with chondroitinase ABC and collagenase to degrade the proteoglycan and the collagen constituents in articular cartilage, respectively. Enzymatically degraded samples were compared to the untreated samples using CEμCT and reference methods, such as Fourier-transform infrared imaging. Decrease in the X-ray attenuation of PTA in articular cartilage and collagen content was observed in cartilage depth of 0–13% and deeper in tissue after collagen degradation. Increase in the X-ray attenuation of PTA was observed in the cartilage depth of 13–39% after proteoglycan degradation. The X-ray attenuation of PTA-labelled articular cartilage in CEμCT is associated mainly with collagen content but the proteoglycans have a minor effect on the X-ray attenuation of the PTA-labelled articular cartilage. In conclusion, the PTA labeling provides a feasible CEμCT method for 3D characterization of articular cartilage. PMID:28135331

  13. Estudios clínicos de neumonitis por hipersensibilidad: Espartosis, suberosis y pulmón del cuidador de aves

    OpenAIRE

    Roger Reig, Àlex

    2013-01-01

    Las neumonitis por hipersensibilidad (NH) son un grupo de enfermedades producidas por la exposición a diferentes sustancias orgánicas, y por su consecuente inhalación, caracterizadas por la presencia de una reacción inflamatoria, en individuos susceptibles, que tiene lugar en alveolos, bronquiolos e intersticio pulmonar. En España, las NH ocupan el 5º lugar en el listado de enfermedades pulmonares intersticiales más frecuentemente diagnosticadas. El pulmón del cuidador de aves (PCA) es la ent...

  14. Asociación HLA y artritis reumatoidea juvenil en busca de las bases moleculares dependiente del MHC /

    OpenAIRE

    Garavito de Egea, Gloria

    2004-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada Artritis reumatoidea Juvenil (ARJ) es una enfermedad inflamatoria crónica, autoinmune que afecta a mas de una articulación en lugar y numero. Es una de las enfermedades más comunes en la consulta pediátrica reumatológica y una de las menos estudiadas desde el punto de vista inmunogenetico. En la literatura se ha reportado varias asociaciones de (HLA) Antigenos de Leucocitos Humanos y ARJ con diferentes grupos étnicos, so...

  15. El estudio de la edad para la identificación humana: estudio antropológico forense en el complejo articular del hombro y en el esternón para la estimación de la mayoría de edad legal y de la edad de la muerte

    OpenAIRE

    Benito Sánchez, María

    2015-01-01

    La reciente demanda de estudios que requieren la estimación de la edad en la Administración de Justicia, ha hecho que tengan que aumentar las investigaciones en el campo de la Antropología Forense, con el fin de responder de la manera más eficaz a las preguntas que se formulan. La Antropología Forense es una subdisciplina reciente, que se remonta a principios del siglo XX, que se encuentra incluida dentro de la Antropología Física y muy vinculada a la Medicina Legal, cuyo objetivo principal e...

  16. Uso de concentrados autólogos de plaquetas intraarticulares como coadyuvantes en el tratamiento quirúrgico de la rotura del ligamento cruzado anterior en una perra Use of intra-articular autologous platelet concentrates as coadjutants in the surgical treatment of a cranial cruciate ligament rupture in a bitch

    OpenAIRE

    RF Silva; CMF Rezende; JU Carmona

    2011-01-01

    La ruptura del ligamento cruzado anterior (RLCA) es uno de los principales problemas ortopédicos que producen cojera de los miembros posteriores en perros. A pesar de que este problema sea tratado quirúrgicamente el desarrollo y progresión de la osteoartritis son típicamente característicos. Se describe un caso de un perro que recibió inyecciones intraarticulares de concentrados autólogos de plaquetas (APCs) durante el posoperatorio después de la reparación quirúrgica de una RLCA. Los resulta...

  17. Efectividad y seguridad de la viscosuplementación con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA) para el tratamiento del dolor secundario a gonartrosis Efficacy and safety of single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) for gonarthrosis pain treatment

    OpenAIRE

    2012-01-01

    Objetivos: valorar la efectividad y seguridad de la inyección de dosis única de ácido hialurónico estabilizado de origen no animal (NASHA) para el tratamiento del dolor secundario a gonartrosis. Material y métodos: se han incluido un total de 37 pacientes afectos de gonartrosis diagnosticada previamente por el Traumatólogo/Reumatólogo en los que ha fracasado el tratamiento conservador y/o que no son tributarios de tratamiento quirúrgico. Se les ha efectuado una infiltración en dosis única de ...

  18. Metabolic Effects of Avocado/Soy Unsaponifiables on Articular Chondrocytes

    Directory of Open Access Journals (Sweden)

    Louis Lippiello

    2008-01-01

    Full Text Available Avocado/soy unsaponifiable (ASU components are reported to have a chondroprotective effect by virtue of anti-inflammatory and proanabolic effects on articular chondrocytes. The identity of the active component(s remains unknown. In general, sterols, the major component of unsaponifiable plant material have been demonstrated to be anti-inflammatory in vitro and in animal models. These studies were designed to clarify whether the sterol content of ASU preparations were the primary contributors to biological activity in articular chondrocytes. ASU samples were analyzed by high pressure liquid chromatography (HPLC and GC mass spectrometry. The sterol content was normalized between diverse samples prior to in vitro testing on bovine chondrocytes. Anabolic activity was monitored by uptake of 35-sulfate into proteoglycans and quantitation of labeled hydroxyproline and proline content after incubation with labeled proline. Anti-inflammatory activity was assayed by measuring reduction of interleukin-1 (IL-1-induced synthesis of PGE2 and metalloproteases and release of label from tissue prelabeled with S-35.All ASU samples exerted a similar time-dependent up-regulation of 35-sulfate uptake in bovine cells reaching a maximum of greater than 100% after 72 h at sterol doses of 1–10 μg/ml. Non-collagenous protein (NCP and collagen synthesis were similarly up-regulated. All ASU were equally effective in dose dependently inhibiting IL-1-induced MMP-3 activity (23–37%, labeled sulfate release (15–23% and PGE2 synthesis (45–58%. Up-regulation of glycosaminoglycan and collagen synthesis and reduction of IL-1 effects in cartilage are consistent with chondroprotective activity. The similarity of activity of ASU from diverse sources when tested at equal sterol levels suggests sterols are important for biologic effects in articular chondrocytes.

  19. Biochemical composition of the superficial layer of articular cartilage.

    Science.gov (United States)

    Crockett, R; Grubelnik, A; Roos, S; Dora, C; Born, W; Troxler, H

    2007-09-15

    To gain more information on the mechanism of lubrication in articular joints, the superficial layer of bovine articular cartilage was mechanically removed in a sheet of ice that formed on freezing the cartilage. Freeze-dried samples contained low concentrations of chondroitin sulphate and protein. Analysis of the protein by SDS PAGE showed that the composition of the sample was comparable to that of synovial fluid (SF). Attenuated total reflection infrared (ATR-IR) spectroscopy of the dried residue indicated that the sample contained mostly hyaluronan. Moreover, ATR-IR spectroscopy of the upper layer of the superficial layer, adsorbed onto silicon, showed the presence of phospholipids. A gel could be formed by mixing hyaluronan and phosphatidylcholine in water with mechanical properties similar to those of the superficial layer on cartilage. Much like the superficial layer of natural cartilage, the surface of this gel became hydrophobic on drying out. Thus, it is proposed that the superficial layer forms from hyaluronan and phospholipids, which associate by hydrophobic interactions between the alkyl chains of the phospholipids and the hydrophobic faces of the disaccharide units in hyaluronan. This layer is permeable to material from the SF and the cartilage, as shown by the presence of SF proteins and chondroitin sulphate. As the cartilage dries out after removal from the joint, the phospholipids migrate towards the surface of the superficial layer to reduce the surface tension. It is also proposed that the highly efficient lubrication in articular joints can, at least in part, be attributed to the ability of the superficial layer to adsorb and hold water on the cartilage surface, thus creating a highly viscous boundary protection.

  20. Progression of articular cartilage degeneration after application of muscle stretch.

    Science.gov (United States)

    Dias, Carolina Náglio Kalil; Renner, Adriana Frias; dos Santos, Anderson Amaro; Vasilceac, Fernando Augusto; Mattiello, Stela Márcia

    2012-01-01

    The aim of study was to evaluate the progression of the ankle articular cartilage alterations after a post-immobilization muscle stretching. Twenty-nine Wistar rats were separated into five groups: C--control, S--stretched, SR--stretch recovery, IS--immobilized and stretched, and ISR--immobilized stretched recovery. The immobilization was maintained for 4 weeks and the left ankle was then stretched manually through a full dorsal flexion for 10 times for 60 s with a 30 s interval between each 60 s period, 7 days/week for 3 weeks. The recovery period was of 7 weeks. At the end of the experiment, the left ankles were removed, processed in paraffin, and stained in hematoxylin-eosin and safranin O. Two blinded observers evaluated the articular cartilage using the Mankin grading system (cellularity, chondrocyte cloning, and proteoglycan content) through light microscopy, and performed the morphometry (cellularity, total thickness, non-calcified thickness, and calcified thickness measures). Both the Mankin grading system and the morphometric analysis showed that the ISR group presented the most increased cellularity among the groups. The IS and SR groups showed the highest proteoglycan loss, and the ISR group showed the same content of proteoglycan observed in the C group. No significant differences were found in the chondrocyte cloning, the total cartilage thickness, the non-calcified cartilage thickness, and the calcified cartilage thickness among the groups. The results suggest that the cartilage can recover the proteoglycan loss caused by immobilization and stretching, probably because of the increased chondrocyte density. Therefore, the ankle articular cartilage responded as to repair the metabolic deficits.

  1. Metabolic Effects of Avocado/Soy Unsaponifiables on Articular Chondrocytes

    Science.gov (United States)

    Nardo, Joseph V.; Harlan, Robert; Chiou, Tiffany

    2008-01-01

    Avocado/soy unsaponifiable (ASU) components are reported to have a chondroprotective effect by virtue of anti-inflammatory and proanabolic effects on articular chondrocytes. The identity of the active component(s) remains unknown. In general, sterols, the major component of unsaponifiable plant material have been demonstrated to be anti-inflammatory in vitro and in animal models. These studies were designed to clarify whether the sterol content of ASU preparations were the primary contributors to biological activity in articular chondrocytes. ASU samples were analyzed by high pressure liquid chromatography (HPLC) and GC mass spectrometry. The sterol content was normalized between diverse samples prior to in vitro testing on bovine chondrocytes. Anabolic activity was monitored by uptake of 35-sulfate into proteoglycans and quantitation of labeled hydroxyproline and proline content after incubation with labeled proline. Anti-inflammatory activity was assayed by measuring reduction of interleukin-1 (IL-1)-induced synthesis of PGE2 and metalloproteases and release of label from tissue prelabeled with S-35.All ASU samples exerted a similar time-dependent up-regulation of 35-sulfate uptake in bovine cells reaching a maximum of greater than 100% after 72 h at sterol doses of 1–10 μg/ml. Non-collagenous protein (NCP) and collagen synthesis were similarly up-regulated. All ASU were equally effective in dose dependently inhibiting IL-1-induced MMP-3 activity (23–37%), labeled sulfate release (15–23%) and PGE2 synthesis (45–58%). Up-regulation of glycosaminoglycan and collagen synthesis and reduction of IL-1 effects in cartilage are consistent with chondroprotective activity. The similarity of activity of ASU from diverse sources when tested at equal sterol levels suggests sterols are important for biologic effects in articular chondrocytes. PMID:18604259

  2. ROCK inhibitor prevents the dedifferentiation of human articular chondrocytes

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Emi [Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kitaku, Okayama 700-8558 (Japan); Furumatsu, Takayuki, E-mail: matino@md.okayama-u.ac.jp [Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kitaku, Okayama 700-8558 (Japan); Kanazawa, Tomoko; Tamura, Masanori; Ozaki, Toshifumi [Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikatacho, Kitaku, Okayama 700-8558 (Japan)

    2012-03-30

    Highlights: Black-Right-Pointing-Pointer ROCK inhibitor stimulates chondrogenic gene expression of articular chondrocytes. Black-Right-Pointing-Pointer ROCK inhibitor prevents the dedifferentiation of monolayer-cultured chondrocytes. Black-Right-Pointing-Pointer ROCK inhibitor enhances the redifferentiation of cultured chondrocytes. Black-Right-Pointing-Pointer ROCK inhibitor is useful for preparation of un-dedifferentiated chondrocytes. Black-Right-Pointing-Pointer ROCK inhibitor may be a useful reagent for chondrocyte-based regeneration therapy. -- Abstract: Chondrocytes lose their chondrocytic phenotypes in vitro. The Rho family GTPase ROCK, involved in organizing the actin cytoskeleton, modulates the differentiation status of chondrocytic cells. However, the optimum method to prepare a large number of un-dedifferentiated chondrocytes is still unclear. In this study, we investigated the effect of ROCK inhibitor (ROCKi) on the chondrogenic property of monolayer-cultured articular chondrocytes. Human articular chondrocytes were subcultured in the presence or absence of ROCKi (Y-27632). The expression of chondrocytic marker genes such as SOX9 and COL2A1 was assessed by quantitative real-time PCR analysis. Cellular morphology and viability were evaluated. Chondrogenic redifferentiation potential was examined by a pellet culture procedure. The expression level of SOX9 and COL2A1 was higher in ROCKi-treated chondrocytes than in untreated cells. Chondrocyte morphology varied from a spreading form to a round shape in a ROCKi-dependent manner. In addition, ROCKi treatment stimulated the proliferation of chondrocytes. The deposition of safranin O-stained proteoglycans and type II collagen was highly detected in chondrogenic pellets derived from ROCKi-pretreated chondrocytes. Our results suggest that ROCKi prevents the dedifferentiation of monolayer-cultured chondrocytes, and may be a useful reagent to maintain chondrocytic phenotypes in vitro for chondrocyte

  3. Relation between shape of the articular eminence and disc displacement in the temporomandibular joint

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Heung Ki; Hwang, Eui Hwan; Lee, Sang Rae [Kyung Hee Univ. College of Dentistry, Seoul (Korea, Republic of)

    2001-09-15

    To investigate the hypothesis that the morphology of the articular eminence of the temporomandibular joint is a predisposing factor for disc displacement. MR images of 126 temporomandibular joints in 94 patients were analyzed to assess for morphology of the articular eminence and disc displacement. The displaced disc was further categorized as disc displacement with reduction (DDWR) and disc displacement without reduction (DDWOR). The morphology of the articular eminence was classified into four types; box, sigmoid, flattened, and deformed. The relationship between the four types of shape of the articular eminence and the two types of disc position was assessed. In the DDWR and DDWOR groups, the morphology of articular eminence were a box type in 40.5%, a sigmoid type in 30.2%, a flattened type in 24.6%, and a deformed type in 4.7%. The box type of the articular eminence were 34.3% in the DDWR group and 42.9% in the DDWOR group. The sigmoid type of the articular eminence were 34.3% in the DDWR group and 28.6% in the DDWOR group. The flattened type of the articular eminence were 28.6% in the DDWR group and 23.1% in the DDWOR group. The deformed type of the articular eminence were 2.9% in the DDWR group and 5.5% in the DDWOR group. Disc displacement in more likely to be found in the temporomandibular joints with a box-shaped articular eminence. It can be considered that shape of the articular eminence is related to the development of disc displacement.

  4. Extra-articular Synovial Chondromatosis Eroding and Penetrating the Acromion

    Science.gov (United States)

    El Rassi, George; Matta, Jihad; Hijjawi, Ayman; Khair, Ousama Abou; Fahs, Sara

    2015-01-01

    Synovial chondromatosis of the shoulder is an uncommon disorder. It usually affects the glenohumeral joint and is characterized by metaplasia of the synovium leading to the formation of osteochondral loose bodies. Few cases of extra-articular subacromial synovial chondromatosis involving the rotator cuff tendon have been reported in the literature. The treatment of previously reported cases consisted of open bursectomy and removal of loose bodies. We report a case of subacromial synovial chondromatosis without rotator cuff involvement but with severe erosion and fracture of the acromion. Treatment consisted of shoulder arthroscopy to remove all loose bodies, total bursectomy, and debridement of the acromion. Potential benefits of arthroscopy were also evaluated. PMID:26697302

  5. Papel de la cascada del ácido araquidónico en la función epitelial de barrera en un modelo de células intestinales Caco-2

    OpenAIRE

    Rodríguez Lagunas, M. José

    2013-01-01

    [spa] El epitelio intestinal forma una barrera que permite el paso de nutrientes pero restringe el de substancias potencialmente nocivas. La alteración de dicha función se relación a con enfermedades gastrointestinales como la enfermedad inflamatoria intestinal (IBD) en la que, además, la producción de eicosanoides en la mucosa intestinal se encuentra incrementada. Por ese motivo, el objetivo del presente trabajo ha sido investigar el papel de los eicosanoides producidos en la cascada del áci...

  6. Influencia del entrenamiento del equilibrio con plataforma dinamométrica en artroplastia total de rodilla

    OpenAIRE

    Roig-Casasús, Sergio

    2015-01-01

    Introducción: Debido al en envejecimiento de la población y al aumento en la esperanza de vida, en la actualidad la artroplastia de rodilla es una de las cirugías más frecuentes en el primer mundo. Las causas más frecuentes del reemplazo protésico son la artrosis y la artritis reumatoidea. Dependiendo del dolor, la limitación articular y la impotencia funcional, el cirujano determina dicha cirugía. Gran parte del éxito de esta cirugía tanto a nivel motor como funcional depende en gran medida ...

  7. Miopatías inflamatorias idiopáticas : Caracterización clínica, de laboratorio y patológica de una serie de 35 pacientes.

    OpenAIRE

    Sahuquillo Hernández, Patricia

    2012-01-01

    Estudio descriptivo y retrospectivo de una serie de 35 pacientes con miopatía inflamatoria idiopática, que a partir de la recogida de variables clínicas, de laboratorio y patológicas, se propone los siguientes objetivos: caracterizar a este grupo de enfermedades, clasificar a los pacientes en subgrupos en función de criterios histopatológicos y caracterizar los distintos subgrupos analizando qué variables permiten diferenciar mejor cada categoría. Estudi descriptiu y retrospectiu de una se...

  8. Cirugía bariátrica en enfermedad inflamatoria intestinal: presentación de un caso clínico y revisión de la literatura

    OpenAIRE

    Carmen Tenorio Jiménez; Gregorio Manzano García; Inmaculada Prior Sánchez; María Sierra Corpas Jiménez; María José Molina Puerta; Pedro Benito López

    2013-01-01

    La Enfermedad Inflamatoria Intestinal (EII) raramente se asocia a obesidad, ya que la malabsorción es una característica frecuente de este grupo de patologías (1). Sin embargo, algunos pacientes pueden padecer obesidad mórbida asociada a complicaciones y refractaria a tratamiento dietético y beneficiarse de la cirugía bariátrica. Incluso se ha postulado que podría producirse una mejoría de la EII al disminuir los marcadores inflamatorios tras la cirugía (2). No obstante, los pacientes pueden ...

  9. Impacto de la nutrición en la evolución de la enfermedad inflamatoria intestinal Impact of nutritional treatment in the evolution of inflammatory bowel disease

    OpenAIRE

    M.ª D. Ballesteros Pomar; A. Vidal Casariego; A. Calleja Fernández; J. J. López Gómez; A. Urioste Fondo; I. Cano Rodríguez

    2010-01-01

    La enfermedad inflamatoria intestinal es una entidad de etiopatogenia aún no bien conocida, con importantes implicaciones nutricionales y metabólicas, por la alta prevalencia de malnutrición que conlleva; por la posible implicación de factores dietéticos en su patogenia; y por la hipótesis de que la intervención nutricional pudiera ser un tratamiento primario de la enfermedad. Algunos nutrientes, además de su función exclusivamente nutricional, podrían inducir un bajo estímulo antigénico, reg...

  10. Importancia de los lípidos en el tratamiento nutricional de las patologías de base inflamatoria Importance of lipids in the nutritional treatment of inflammatory diseases

    OpenAIRE

    M. D. Mesa García; C. M. Aguilera García; A. Gil Hernández

    2006-01-01

    En las últimas décadas, el conocimiento acerca de las propiedades antiinflamatorias de los lípidos ha facilitado el desarrollo de productos adaptados a la nutrición enteral y parenteral que han sido utilizados como terapia en numerosas enfermedades de base inflamatoria. En esta revisión se ofrece una visión general de los efectos de los lípidos utilizados en nutrición enteral, sobre ciertas patologías en cuya base están implicados procesos inflamatorios, como es el caso de las enfermedades in...

  11. Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage

    NARCIS (Netherlands)

    Chen, A.C.; Temple, M.M.; Ng, D.M.; Verzijl, N.; Groot, J. de; TeKoppele, J.M.; Sah, R.L.

    2002-01-01

    Objective. To determine whether increasing advanced glycation end products (AGEs) in bovine articular cartilage to levels present in aged human cartilage modulates the tensile biomechanical properties of the tissue. Methods. Adult bovine articular cartilage samples were incubated in a buffer solutio

  12. Pseudomonas aeruginosa septic arthritis of knee after intra-articular ozone injection.

    Science.gov (United States)

    Seyman, Derya; Ozen, Nevgun Sepin; Inan, Dilara; Ongut, Gozde; Ogunc, Dilara

    2012-07-01

    We describe a case of septic arthritis caused by Pseudomonas aeruginosa in an immunocompetent patient following intra-articular ozone injection into the knee. To the best of our knowledge, and after considering the current literature,we believe this case is unique as no other reports of septic arthritis caused by P. aeruginosa following intra-articular ozone injection has been made.

  13. [Systematization of the articular surfaces of the carpometacarpal joints (author's transl)].

    Science.gov (United States)

    el Bacha, A; Maillot, C

    1977-01-01

    A study, done on 100 hands, of the systematization of the articular surfaces of the carpometacarpal joints, clearly delineates the variability of circumference, dimesions, and relief of the articular facets. An attempt to draw general conclusions from this morphological study, in terms of arthrokinetics, leads to an understanding of the nature of the joints and the movements that are performed at this site.

  14. Detailed Analysis of the Articular Domain in Patients with Primary Sjögren Syndrome

    NARCIS (Netherlands)

    Arends, Suzanne; Meiners, Petra M; Moerman, Rada V; Vissink, Arjan; Spijkervet, Frederik K L; Kroese, Frans G M; Brouwer, Elisabeth; Bootsma, Hendrika

    2017-01-01

    OBJECTIVE: We used the 28-joint Disease Activity Score (DAS28) and the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) articular domain to assess the effect of rituximab (RTX) and abatacept (ABA) on articular involvement in primary Sjögren syndrome (pSS). METHOD

  15. Non-linear model for compression tests on articular cartilage.

    Science.gov (United States)

    Grillo, Alfio; Guaily, Amr; Giverso, Chiara; Federico, Salvatore

    2015-07-01

    Hydrated soft tissues, such as articular cartilage, are often modeled as biphasic systems with individually incompressible solid and fluid phases, and biphasic models are employed to fit experimental data in order to determine the mechanical and hydraulic properties of the tissues. Two of the most common experimental setups are confined and unconfined compression. Analytical solutions exist for the unconfined case with the linear, isotropic, homogeneous model of articular cartilage, and for the confined case with the non-linear, isotropic, homogeneous model. The aim of this contribution is to provide an easily implementable numerical tool to determine a solution to the governing differential equations of (homogeneous and isotropic) unconfined and (inhomogeneous and isotropic) confined compression under large deformations. The large-deformation governing equations are reduced to equivalent diffusive equations, which are then solved by means of finite difference (FD) methods. The solution strategy proposed here could be used to generate benchmark tests for validating complex user-defined material models within finite element (FE) implementations, and for determining the tissue's mechanical and hydraulic properties from experimental data.

  16. Intra-articular Implantation of Mesenchymal Stem Cells, Part 2

    Science.gov (United States)

    Kraeutler, Matthew J.; Mitchell, Justin J.; Chahla, Jorge; McCarty, Eric C.; Pascual-Garrido, Cecilia

    2017-01-01

    Knee osteoarthritis (OA) after partial or total meniscectomy is a prevalent issue that patients must face. Various methods of replacing meniscal tissue have been studied to avoid this progression, including meniscal allograft transplantation, meniscal scaffolds, and synthetic meniscus replacement. Studies have shown that meniscal scaffolds may improve symptoms but have not been shown to prevent progression of OA. Recently, mesenchymal stem cells (MSCs) have been proposed as a possible biological therapy for meniscal regeneration. Several animal studies and 1 human study have evaluated the effect of transplanting MSCs into the knee joint after partial meniscectomy. The purpose of this review was to assess the outcomes of intra-articular transplantation of MSCs on meniscal regeneration in animals and humans after partial meniscectomy. Limited results from animal studies suggest that there is some potential for intra-articular injection of MSCs for the regeneration of meniscal tissue. However, further studies are necessary to determine the quality of regenerated meniscal tissue through histological and biomechanical testing. PMID:28203596

  17. Roturas tendinosas y musculares en el hombro del deportista

    OpenAIRE

    Sanchis, V.; Gastaldi Orquin, E.; Ferrando, F; Diago, T.; Deltoro López, A.

    1991-01-01

    El complejo articular del hombro está sometido a solicitaciones mecánicas en la mayoría de las modalidades deportivas; así el 10-15% de los traumatismos sufridos por los atletas afectan a esta articulación (1). La "patología reina" del hombro del deportista es la inestabilidad, por su frecuencia, importantes implicaciones funcionales y tratamiento problemático. Por el contrario, las roturas musculares y tendinosas del hombro son lesiones poco frecuentes en el dep...

  18. Topographic matching of distal radius and proximal fibula articular surface for distal radius osteoarticular reconstruction.

    Science.gov (United States)

    Zhang, H; Chen, S; Wang, Z; Guo, Y; Liu, B; Tong, D

    2016-07-01

    During osteoarticular reconstruction of the distal radius with the proximal fibula, congruity between the two articular surfaces is an important factor in determining the quality of the outcome. In this study, a three-dimensional model and a coordinate transformation algorithm were developed on computed tomography scanning. Articular surface matching was performed and parameters for the optimal position were determined quantitatively. The mean radii of best-fit spheres of the articular surfaces of the distal radius and proximal fibula were compared quantitatively. The radial inclination and volar tilt following reconstruction by an ipsilateral fibula graft, rather than the contralateral, best resembles the values of the native distal radius. Additionally, the ipsilateral fibula graft reconstructed a larger proportion of the distal radius articular surface than did the contralateral. The ipsilateral proximal fibula graft provides a better match for the reconstruction of the distal radius articular surface than the contralateral, and the optimal position for graft placement is quantitatively determined.

  19. Extra-articular hip impingement: a narrative review of the literature

    Science.gov (United States)

    Cheatham, Scott W.

    2016-01-01

    There is growing subgroup of patients with poor outcomes after hip arthroscopy for intra-articular pathology suggesting unrecognized cause(s) of impingement may exist. Extra-articular hip impingement (EHI) is an emerging group of conditions that have been associated with intra-articular causes of impingement and may be an unrecognized source of pain. EHI is caused by abnormal contact between the extra-articular regions of the proximal femur and pelvis. This review discusses the most common forms for EHI including: central iliopsoas impingement, subspine impingement, ischiofemoral impingement, and greater trochanteric-pelvic impingement. The clinical presentation of each pathology will be discussed since EHI conditions share similar clinical features as the intra-articular pathology but also contain some unique characteristics. PMID:27069266

  20. Secondary knee instability caused by fracture of the stabilizing insert in a dual-articular total knee

    DEFF Research Database (Denmark)

    Boesen, Morten P; Jensen, Tim Toftgaard; Husted, Henrik

    2004-01-01

    A case of a fractured polyethylene stabilizing insert causing secondary knee instability in a Dual-articular total knee arthroplasty (TKA) is presented. A 65-year-old woman who underwent surgery with a Dual-articular TKA 4 years earlier had a well-functioning prosthesis until a fall, after which......-articular knee....

  1. Intra-articular injection of tenoxicam in rats: assessment of the local effects on the articular cartilage and synovium.

    Science.gov (United States)

    Ozyuvaci, H; Bilgic, B; Ozyuvaci, E; Altan, A; Altug, T; Karaca, C

    2004-01-01

    This study investigated the possible local adverse effects of intra-articular administration of tenoxicam in the rat knee joint. A total of 50 rats were given 0.25 ml of a standard preparation of tenoxicam by injection into the right knee joint and 0.25 ml of 0.9% saline solution by injection into the left knee joint as a control. Groups of 10 rats were killed 24 h, 48 h, 7 days, 14 days and 21 days after tenoxicam administration. Two rats were sham operated; one was killed on the first day and the other on the second day after this procedure. All the joints were prepared and sectioned for histological examination. Tissue loss and oedema were observed in the specimens obtained 24 h and 48 h after treatment with tenoxicam. No pathological changes were observed in the 7-day, 14-day and 21-day specimens, or in the control joints. Caution should be exercised when using intra-articular tenoxicam for post-operative analgesia.

  2. Enfermedades articulares y uveítis Articular diseases and uveitis

    Directory of Open Access Journals (Sweden)

    J.M. Benítez del Castillo

    2008-01-01

    Full Text Available La inflamación ocular es una manifestación clínica frecuente de múltiples enfermedades sistémicas autoinmunes, siendo de gran relevancia en las espondiloartropatías. Dentro del grupo de las espondiloartropatías existen diferentes entidades clínicas, asociándose a diferentes patrones de uveítis. Se han definido una serie de patrones discriminativos que relacionan formas concretas de uveítis con determinadas enfermedades sistémicas u oculares. La uveítis anterior aguda unilateral recidivante es la más frecuente en las espondiloartropatías, y puede ser la forma de inicio de una espondiloartropatía no diagnosticada previamente. La colaboración entre oftalmólogos y reumatólogos o internistas es fundamental para el correcto manejo y tratamiento de estos pacientes.Ocular inflammation is a common clinical manifestation related to several autoimmune systemic disorders, specially spondyloarthropaties. In this group, there are different clinical diseases that are related to special uveitic patterns. Several discriminative patterns have been defined that closely link uveitis with certain systemic or ophthalmic diseases. Unilateral recurrent anterior acute uveitis is the most frequent form of uveitis related to spondyloarthropaties, and is sometimes the initial manifestation of an undiagnosed spondyloarthropaty. The collaboration of ophthalmologists, rheumatologists and internal medicine specialists is very important for the correct management and treatment of these patients.

  3. Articular cartilage repair and the evolving role of regenerative medicine

    Directory of Open Access Journals (Sweden)

    Pieter K Bos

    2010-10-01

    Full Text Available Pieter K Bos1, Marloes L van Melle1, Gerjo JVM van Osch1,21Department of Orthopaedic Surgery, Erasmus MC, Rotterdam, the Netherlands; 2Department of Otorhinolaryngology, Erasmus MC, Rotterdam, the NetherlandsAbstract: Among the growing applications of regenerative medicine, clinical articular cartilage repair has now been used for 2 decades and forms a successful example of translational medicine. Cartilage is characterized by a limited intrinsic repair capacity following injury. Articular cartilage defects cause symptoms, are not spontaneously repaired, and are generally believed to result in early osteoarthritis. Marrow stimulation techniques, osteochondral transplantation, and cell-based therapies, such as autologous chondrocyte implantation (ACI and use of mesenchymal stem cells (MSCs, are used for tissue regeneration, symptom relief, and prevention of further joint degeneration. The exact incidence of cartilage defects and the natural outcome of joints with these lesions are unclear. Currently available cartilage repair techniques are designed for defect treatment in otherwise healthy joints and limbs, mostly in young adults. The natural history studies presented in this review estimated that the prevalence of cartilage lesions in this patient group ranges from 5% to 11%. The background and results from currently available randomized clinical trials of the three mostly used cartilage repair techniques are outlined in this review. Osteochondral transplantation, marrow stimulation, and ACI show improvement of symptoms with an advantage for cell-based techniques, but only a suggestion that risk for joint degeneration can be reduced. MSCs, characterized by their good proliferative capacity and the potential to differentiate into different mesenchymal lineages, form an attractive alternative cell source for cartilage regeneration. Moreover, MSCs provide a regenerative microenvironment by the secretion of bioactive factors. This trophic activity

  4. Estudio del estado de salud oral y salival en relación con las complicaciones de diabéticos tipo 1

    OpenAIRE

    Hontanilla Estruch, Estela

    2014-01-01

    En la actualidad está reconocido que la patogénesis de la diabetes está muy influenciada por una activación del sistema inmune y por un bajo grado de inflamación. Las principales citoquinas que participan en la patogénesis de la diabetes son la IL-1, el TNF- , y la IL-6. Además, algunos estudios recientes han demostrado que la inflamación, y más concretamente las citoquinas inflamatorias, son determinantes en el desarrollo de las complicaciones microvasculares de la diabetes: neuropatía, reti...

  5. Esclerosis múltiple en una mujer fallecida por quemaduras en el incendio del domicilio Multiple sclerosis in a woman died by burns in a house fire

    OpenAIRE

    J. Lucena; M. Salguero; A. Rico; Blanco, M.; Marín, R.; E. Barrero; F. Heredia

    2004-01-01

    La esclerosis múltiple (EM) o esclerosis en placas es la más común de las enfermedades inflamatorias desmielinizantes del SNC y el trastorno neurológico más incapacitante en los adultos jóvenes. Se caracteriza por la aparición de lesiones focales diseminadas en la sustancia blanca denominadas placas en las que lo más llamativo es la pérdida de la mielina (desmielinización) con preservación relativa de los axones. Es infrecuente que esta enfermedad entre en el campo de investigación médico-for...

  6. Biomecánica del complejo periastragalino

    OpenAIRE

    Angulo Carrere, Mª. T.; Llanos Alcazar, L.F.

    1994-01-01

    Bajo el concepto funcional de «COMPLEJO PERIASTRAGALINOD, se realiza una revisión de las característifas biomecánicas de las articulaciones que lo constituye. Se estudia la movilidad de la articulación del tobillo, haciendo referencia a su papel en la transmisión de cargas y a su importancia en el mantenimiento de la estabilidad y congruencia articular de la unión del pie al extremo dista1 de la pierna, a traves de la existencia de un potente sistema ligamentoso. ...

  7. Condromatosis sinovial del hombro.

    OpenAIRE

    2012-01-01

    La osteocondromatosis sinovial es una metaplasia idiopática benigna de la membrana sinovial. Las manifestaciones están en relación con los cuerpos libres intra-articulares y la excesiva actividad física, las que pueden hacer que esta condición sea sintomática y potencialmente ser causa de artropatía degenerativa. Un varón de 32 años refirió dolor periódico del hombro izquierdo, en la radiografía se encontró el signo de “la tormenta de nieve”, fue tratado con cirugía y la anatomía patológica m...

  8. Immortalization of human articular chondrocytes and induction of their phenotype

    Institute of Scientific and Technical Information of China (English)

    何清义; 李起鸿; 杨柳; 许建中

    2003-01-01

    Objective To immortalize human articular chondrocytes (HACs) using gene transfection and to maintain stable phenotype of transformed HACs after induction.Methods HACs were transfected with the retroviral vector pLXSN encoding human papillomavirus 16E7 (HPV16E7), and the transformed clones were sorted and proliferated. Karyotype analysis, clone forming tests and nude mice tumor forming tests were applied to check the characteristics of the transformation. Type Ⅱ collagen of transformed chondrocytes was inducted with free serum medium (FSM) supplemented with nutridoma-sp and ascorbate. Results Immortalized HACs were isolated with fifty passages achieved. The HPV16E7 transformed cells were confirmed to be benign. Induction of FSM with nutridoma-sp and ascorbate promoted type Ⅱ collagen of transformed chondrocytes to the high levels of normal chondrocytes. Conclusion HACs transformed with HPV16E7 survive for long periods in vitro, and type Ⅱ collagen can maintain stability after induction.

  9. [Gait analysis after intra-articular calcaneus fractures].

    Science.gov (United States)

    Siegmeth, A; Petje, G; Mittlmeier, T; Vécsei, V

    1996-01-01

    We retrospectively compared 20 patients with displaced intra-articular calcaneal fractures by clinical assessment and dynamic pedography. Eleven were treated operatively, 9 conservatively. The purpose was to identify differences in post-traumatic gait performance and to correlate the pedographic data to a clinical score to show its reliability. Twenty individuals without a history of foot injuries were used as a control group. Both groups had restricted motion in the subtalar joint, increased hindfoot and midfoot loading and decreased forefoot loading. Furthermore, they showed prolonged contact phases and an impaired ability to speed up gait during the toe-off phase. Load transfer from the hindfoot to the forefoot showed typical distribution patterns. The operatively treated group showed better functional results with fewer subjective complaints.

  10. bFGF influences human articular chondrocyte differentiation

    DEFF Research Database (Denmark)

    Schmal, H; Zwingmann, J; Fehrenbach, M

    2007-01-01

    FGF concentrations in supernatants of primary human articular chondrocytes peaked immediately after isolation and then declined. In a dose-dependent manner, bFGF enhanced cell amplification and viability. BFGF induced a decrease in the apoptotic cell population, while the number of proliferating cells remained...... in monolayer. bFGF-dependent cell proliferation, production of collagen type II and aggrecan were monitored 10 days after isolation. Furthermore, effect of bFGF on cell cycle, cell morphology, and mRNA expression of integrins and chondrogenic markers determined by real time PCR were analyzed. RESULTS: b...... unchanged. Supplementation of cell culture with bFGF reduced collagen type II mRNA by 49%, but increased expression of the integrin alpha(2) by 70%. bFGF did not significantly regulate the integrins alpha(1), alpha(5), alpha(10), alpha(v) and type I collagen. bFGF reduced the amount of collagen type II...

  11. Contact mechanics of articular cartilage layers asymptotic models

    CERN Document Server

    Argatov, Ivan

    2015-01-01

    This book presents a comprehensive and unifying approach to articular contact mechanics with an emphasis on frictionless contact interaction of thin cartilage layers. The first part of the book (Chapters 1–4) reviews the results of asymptotic analysis of the deformational behavior of thin elastic and viscoelastic layers. A comprehensive review of the literature is combined with the authors’ original contributions. The compressible and incompressible cases are treated separately with a focus on exact solutions for asymptotic models of frictionless contact for thin transversely isotropic layers bonded to rigid substrates shaped like elliptic paraboloids. The second part (Chapters 5, 6, and 7) deals with the non-axisymmetric contact of thin transversely isotropic biphasic layers and presents the asymptotic modelling methodology for tibio-femoral contact. The third part of the book consists of Chapter 8, which covers contact problems for thin bonded inhomogeneous transversely isotropic elastic layers, and Cha...

  12. Effects of Cryoprotective Agents on the Bovine Articular Chondrocyte Viability

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Cryopreservation is the process of choice for long term preservation of cells and tissues. In this study, the effects of cryoprotective agents, dimethyl sulfoxide(DMSO), glycerol and 1,2-propanediol on the bovine articular chondrocyte viability were examined experimentally. The CPA was added at the concentrations of 0. 6. 0.9, 1.2 and 1.5 mol/I and at 4℃ and 37℃ and removed at 37℃ in one-step. CPA stepwise addition and removal at 0. 6 and 1. 2 mol/L and at 37℃ was also tested as an alternative protocol. Cell volume excursion during DMSO addition and removal was estimated and correlated well with cell survival rates. Solution makeup affects cell survival rate and a stepwise protocol can improve the cell survival rates significantly.

  13. Multiphysical modelling of fluid transport through osteo-articular media

    Directory of Open Access Journals (Sweden)

    Thibault Lemaire

    2010-03-01

    Full Text Available In this study, a multiphysical description of fluid transport through osteo-articular porous media is presented. Adapted from the model of Moyne and Murad, which is intended to describe clayey materials behaviour, this multiscale modelling allows for the derivation of the macroscopic response of the tissue from microscopical information. First the model is described. At the pore scale, electrohydrodynamics equations governing the electrolyte movement are coupled with local electrostatics (Gauss-Poisson equation, and ionic transport equations. Using a change of variables and an asymptotic expansion method, the macroscopic description is carried out. Results of this model are used to show the importance of couplings effects on the mechanotransduction of compact bone remodelling.Neste estudo uma descrição multifísica do transporte de fluidos em meios porosos osteo articulares é apresentada. Adaptado a partir do modelo de Moyne e Murad proposto para descrever o comportamento de materiais argilosos a modelagem multiescala permite a derivação da resposta macroscópica do tecido a partir da informação microscópica. Na primeira parte o modelo é apresentado. Na escala do poro as equações da eletro-hidrodinâmica governantes do movimento dos eletrolitos são acopladas com a eletrostática local (equação de Gauss-Poisson e as equações de transporte iônico. Usando uma mudança de variáveis e o método de expansão assintótica a derivação macroscópica é conduzida. Resultados do modelo proposto são usados para salientar a importância dos efeitos de acoplamento sobre a transdução mecânica da remodelagem de ossos compactados.

  14. Partial rotator cuff injury in athletes: bursal or articular?

    Directory of Open Access Journals (Sweden)

    Cassiano Diniz Carvalho

    2015-08-01

    Full Text Available ABSTRACTA painful shoulder is a very common complaint among athletes, especially in the case of those in sports involving throwing. Partial lesions of the rotator cuff may be very painful and cause significant functional limitation to athletes' sports practice. The incidence of partial lesions of the cuff is variable (13-37%. It is difficult to make the clinical and radiological diagnosis, and this condition should be borne in mind in the cases of all athletes who present symptoms of rotator cuff syndrome, including in patients who are diagnosed only with tendinopathy. OBJECTIVE: To evaluate the epidemiological behavior of partial lesions of the rotator cuff in both amateur and professional athletes in different types of sports. METHODS: We evaluated 720 medical files on athletes attended at the shoulder service of the Discipline of Sports Medicine at the Sports Traumatology Center, Federal University of São Paulo. The majority of them were men (65%. Among all the patients, 83 of them were diagnosed with partial lesions of the rotator cuff, by means of ultrasonography or magnetic resonance, or in some cases using both. We applied the binomial test to compare the proportions found. RESULT: It was observed that intra-articular lesions predominated (67.6% and that these occurred more frequently in athletes in sports involving throwing (66%. Bursal lesions occurred in 32.4% of the athletes, predominantly in those who did muscle building (75%. CONCLUSION: Intra-articular lesions are more frequent than bursal lesions and they occur predominantly in athletes in sports involving throwing, while bursal lesions were more prevalent in athletes who did muscle building.

  15. Extra-Articular Manifestations of Rheumatoid Arthritis, Now

    Directory of Open Access Journals (Sweden)

    Paloma Vela

    2014-06-01

    Full Text Available Rheumatoid arthritis (RA is a chronic systemic inflammatory disease, characterised by polyarthritis and extra-articular organ disease, including rheumatoid nodules, ophthalmologic manifestations, cardiopulmonary disease, vasculitis, neuropathy, glomerulonephritis, Felty’s syndrome, and amyloidosis. Extra-articular manifestations of RA (ExRA occur in 17.8–40.9% of RA patients, 1.5–21.5% of them presenting as severe forms and usually associated with increased morbidity and mortality. They can develop at any time during the course of the disease, even in the early stages, and are associated with certain predisposing factors, such as the presence of rheumatoid factor, smoking, and long-standing severe disease. Rheumatoid nodules, the most common ExRA, have been found to be associated with the development of severe features, such as vasculitis, rheumatoid lung disease, pericarditis, and pleuritis, especially in those patients who develop them within 2 years from RA diagnosis. There is no uniformity in the definition of the term ExRA, which limits comparability between different studies. Several recent surveys suggest a lower frequency, probably due to a better control of disease activity. Diagnosis of ExRA is a challenge for clinicians, given its variable and complex presentation, and the lack of specific diagnostic tests; it must be based on clinical recognition and exclusion of other causes of the signs and symptoms. Furthermore, management continues to be difficult with a bad prognosis in many conditions. This article reviews the clinical aspects of major ExRA, focusing on incidence, clinical features, and therapeutic approaches, and how modern immunosuppressive therapy can change the outcome.

  16. Initial approach of patients admitted to third level hospitals with systemic inflamatory response syndrome Enfoque inicial de los pacientes admitidos a hospitales de tercer nivel con síndrome de respuesta inflamatoria sistémica (SRIS

    Directory of Open Access Journals (Sweden)

    Fabián Alberto Jaimes Barragán

    2000-04-01

    . Laboratory requests and microbiological studies did not in every case correlate with the initial diagnosis and the empirical antibiotic therapy. Objetivo: conocer el enfoque inicial de los pacientes con diagnóstico de síndrome de respuesta inflamatoria sistémica de origen infeccioso (SRIS en unidades de urgencias. Diseño: estudio observacional analítico en una cohorte concurrente. Lugar de estudio: servicios de urgencias del Hospital Universitario San Vicente de Paúl (HUSVP y el Hospital General de Medellín Luz Castro de Gutiérrez (HGM. Pacientes: admitidos por urgencias con SRIS de etiología no traumática entre agosto de 1998 y marzo de 1999, de edad igual o superior a 14 años, y con sospecha de infección como uno de los principales diagnósticos de admisión. Mediciones: descripción de la frecuencia de enfermedades asociadas, factores de riesgo y exploración física básica, determinación y utilidad de ayudas diagnósticas más usadas; y asociación entre foco infeccioso, microbiología, uso previo de antibióticos y antibioterapia empírica inicial en la admisión. Se utilizaron Chi cuadrado o prueba exacta de Fisher para la comparación de proporciones. Resultados: fueron admitidos 502 pacientes. Los principales antecedentes fueron EPOC (21.5% y trauma o cirugía previa (18.7%. La toma de signos vitales se determinó de la siguiente forma: frecuencia cardíaca en 100%, frecuencia respiratoria en 94.8%, presión arterial en 99.2%, temperatura en 80.3% y escala de Glasgow en 75.7% de los pacientes. Las solicitudes de laboratorio fueron: recuento de leucocitos en 98.4%, radiografía de tórax en 71.1%, recuento de plaquetas en 94.4% y creatinina en 89% de pacientes. En 26.5% de los pacientes no se solicitó ningún tipo de cultivo; en los restantes los más solicitados fueron los hemocultivos en 48.8% del total de la cohorte, de los cuales hubo crecimiento en 19.2% de las muestras. En 22.3% de los pacientes había habido consumo previo de antibióticos y

  17. Granulocitoaféresis en la enfermedad inflamatoria intestinal: Eficacia a 32 semanas con protocolo de inducción y sesiones de mantenimiento Granulocytapheresis in inflamatory bowel disease: Efficacy of an induction plus maintenance sessions protocol at 32 weeks

    Directory of Open Access Journals (Sweden)

    F. J. Fernández Pérez

    2007-11-01

    Full Text Available Introducción: la granulocitoaféresis (GCAF retira de la circulación granulocitos-monocitos activados, modificando el pool circulante e induciendo una reducción en la inflamación intestinal. Objetivo: valorar la eficacia de la GCAF en la enfermedad inflamatoria intestinal (EII mediante sesiones de inducción y mantenimiento. Material y método: análisis retrospectivo en pacientes con EII activa corticodependiente y corticorrefractaria. Aplicamos 5 sesiones de inducción en colitis ulcerosa (CU y 7 en enfermedad de Crohn (EC y 1 sesión mensual hasta semana 32. Evaluamos indices clínicos de actividad y empleo de corticoides. Resultados: incluimos a 18 pacientes (10 CU, 8 EC, 10 de ellos corticodependientes y 8 corticorrefractarios. Catorce pacientes eran refractarios y 4 intolerantes a inmunosupresores (IS. No completaron la inducción 2-CU (brotes graves y 1-EC (secundarismos. Abandonaron el mantenimiento 1-CU y 3-EC. De aquellos que completaron inducción alcanzaron respuesta o remisión el 87,5% de las CU (2 y 5 pacientes, y el 71,4% de EC (1 y 4 pacientes respectivamente. Estos resultados a 32 semanas eran del 75% en CU (3 y 3 pacientes y del 42,8% en EC (1 y 2 pacientes respectivamente. De los que completaron la inducción, suprimieron corticoides el 14,2% de EC por el 62,5% de CU (25% de estas en remisión y 37,5% en respuesta. Registramos 2 secundarismos graves (tromboflebitis y síncope. Ninguna CU que completó inducción sufrió colectomía tras 97,6 (72-128 semanas de seguimiento. Conclusiones: tanto CU como EC responden bien a inducción con GCAF pero mientras la CU mantiene tras 32 semanas tasas similares de respuesta-remisión (87,5 vs. 75% casi 1/3 de los pacientes con EC recaen tras alcanzar respuesta. La granulocitoaféresis es una alternativa de tratamiento para inducir y mantener remision en CU, ahorrando corticoides, pero en la EC se precisa una adecuada selección de pacientes y un esquema de mantenimiento aún por

  18. Estructuras articulares, funcionales y anatómicas en la técnica de rotura de poder en el Taekwon-do

    OpenAIRE

    Bulens, Marlene

    2013-01-01

    El objetivo de la siguiente ponencia, es examinar aspectos anatómicos-funcionales y biomecánicos necesarios para lograr un correcto gesto técnico de la muñeca y de la mano, durante el desarrollo de la técnica de rotura de poder con golpe de puño en el Taekwon-do que conlleva a una excesiva fuerza de compresión articular que resiste la muñeca y la mano además del constante ajuste de la técnica para reestablecer la estabilidad. Hay tensiones musculares producidas por los músculos del antebra...

  19. Reemplazo total de rodilla en gonartrosis asociada a deformidad extraarticular. [Total knee replacement inosteoarthritis associated with extra-articular deformity

    Directory of Open Access Journals (Sweden)

    Hernan del Sel

    2012-12-01

    Full Text Available Introducción El éxito a largo plazo de un reemplazo total de rodilla (RTR depende de la restitución del eje mecánico del miembro, de la correcta colocación del implante y del balance de partes blandas. Los pacientes con gonartrosis asociada a una deformidad extraarticular, femoral o tibial, requieren de una cuidadosa evaluación y planificación preoperatoria con el objeto de decidir si la corrección del eje podrá realizarse mediante la resección ósea intraarticular, o si deberá asociarse una osteotomía extraarticular. Material y Método Se evaluaron 22 RTR (en 20 pacientes por gonartrosis asociada a deformidad extraarticular. La etiología de la deformidad extraarticular fue postraumática en 8 casos y postosteotomía en 14 (8 femorales y 6 tibiales. Resultados En todos los casos se realizó la corrección del eje del miembro mediante un RTR con cortes óseos intra articulares “inusuales”, sin que fuera necesario realizar una osteotomía. La evaluación clínica y funcional se realizó mediante el sistema de puntaje de la Knee Society2. El promedio de la evaluación clínica fue de 24,3 puntos en el prequirúrgico y 86 al año postoperatorio. Con respecto al puntaje funcional, paso de un promedio de 34 puntos en el prequirúrgico a 85,3 puntos al año. Conclusión No hay un criterio único en relación al tratamiento del paciente con gonartrosis sintomática asociada a una deformidad extraarticular. La corrección de la deformidad extraarticular por medio de cortes óseos intraarticulares ¨inusuales¨ es posible si estos no afectan las inserciones ligamentarias femorales ni tibiales. Este método puede aplicarse en desejes femorales de hasta 20° y tibiales de hasta 30° en el plano coronal. Mediante esta técnica hemos obtenido buenos resultados, a más de 5 años de seguimiento, en 20 de los 22 casos operados.

  20. Acute changes in hamstrings musculo-articular dissipative properties induced by cyclic and static stretching.

    Science.gov (United States)

    Nordez, A; McNair, P; Casari, P; Cornu, C

    2008-05-01

    This study was designed to measure changes in musculo-articular dissipative properties related to viscosity that were induced by passive cyclic and static stretching. Musculo-articular dissipative properties were assessed by calculating a dissipation coefficient using potential elastic energies stored and restituted during cyclic stretching. Eight subjects performed five passive knee extensions/flexions cycles on a Biodex dynamometer at 5 degrees . s (-1) to 80 % of their maximal range of motion before and after a static stretching protocol. Electromyographic activity from the hamstring muscles was monitored and remained constant during cyclic stretching and after static stretching (p > 0.05). The dissipation coefficient decreased during cyclic stretching (- 28.8 +/- 6.0 %, p musculo-articular dissipative properties were primarily affected by a single cycle of motion, and were not influenced by static stretching procedures. The decrease in dissipation coefficient following cyclic motion indicates that the musculo-articular system displays thixotropic behavior.

  1. Effects of immobilization on thickness of superficial zone of articular cartilage of patella in rats

    Directory of Open Access Journals (Sweden)

    Khadija Iqbal

    2012-01-01

    Conclusion: Each segment of superficial zone behaves differentially on immobilization and remobilization. Perhaps a much longer duration of remobilization is required to reverse changes of immobilization in articular cartilage and plays a significant role in knee joint movements.

  2. El control de las omisiones del poder público en materia de Derechos fundamentales.

    OpenAIRE

    Gavara de Cara, Juan Carlos

    2007-01-01

    En este trabajo se analizan las consecuencias del control de las omisiones del poder público en materia de derechos fundamentales, tanto en relación con la actividad del poder legislativo como de los poderes ejecutivo y judicial tras la reciente reforma de la Ley Orgánica del Tribunal Constitucional. Particularmente se examinan las posibilidades de articular un control de carácter material de la insuficiencia normativa de la ley a través del principio de defecto de protección de los...

  3. Intra-Articular Blockade of P2X7 Receptor Reduces the Articular Hyperalgesia and Inflammation in the Knee Joint Synovitis Especially in Female Rats.

    Science.gov (United States)

    Teixeira, Juliana Maia; Dias, Elayne Vieira; Parada, Carlos Amílcar; Tambeli, Cláudia Herrera

    2017-02-01

    Synovitis is a key factor in joint disease pathophysiology, which affects a greater proportion of women than men. P2X7 receptor activation contributes to arthritis, but whether it plays a role in articular inflammatory pain in a sex-dependent manner is unknown. We investigated whether the P2X7 receptor blockade in the knee joint of male and female rats reduces the articular hyperalgesia and inflammation induced by a carrageenan knee joint synovitis model. Articular hyperalgesia was quantified using the rat knee joint incapacitation test and the knee joint inflammation, characterized by the concentration of cytokines tumor necrosis factor-α, interleukin-1β, interleukin-6, and cytokine-induced neutrophil chemoattractant-1, and by neutrophil migration, was quantified using enzyme-linked immunosorbent assay and by myeloperoxidase enzyme activity measurement, respectively. P2X7 receptor blockade by the articular coadministration of selective P2X7 receptor antagonist A740003 with carrageenan significantly reduced articular hyperalgesia, pro-inflammatory cytokine concentrations, and myeloperoxidase activity induced by carrageenan injection into the knee joint of male and estrus female rats. However, a lower dose of P2X7 receptor antagonist was sufficient to significantly induce the antihyperalgesic and anti-inflammatory effects in estrus female but not in male rats. These results suggest that P2X7 receptor activation by endogenous adenosine 5'-triphosphate is essential to articular hyperalgesia and inflammation development in the knee joint of male and female rats. However, female rats are more responsive than male rats to the antihyperalgesic and anti-inflammatory effects induced by P2X7 receptor blockade.

  4. Partial-thickness articular surface rotator cuff tears in patients over the age of 35: Etiology and intra-articular associations

    Directory of Open Access Journals (Sweden)

    Chetan S Modi

    2012-01-01

    Full Text Available Purpose: Partial-thickness articular-sided rotator cuff tears have a multifactorial etiology and are associated with degeneration of the tendon. They are often described as an injury of the young athlete, although they are also found in the older population. The aim of this study was to investigate the frequency and associations of partial-thickness articular-sided tears in patients over the age of 35 years. Design: Retrospective Materials and Methods: A retrospective study of all arthroscopic procedures for rotator cuff pathology in patients over the age of 35 years over a 2-year period by a single surgeon was performed. The included patients were divided into two groups based on the arthroscopic findings: those with a partial-thickness articular-sided rotator cuff tear and those with pure tendinopathy. The groups were then compared to identify the associated pathology with the rotator cuff lesions. 2×2 contingency table analysis and unpaired Student′s t-test were used for statistical analysis. Results: One hundred patients were included in the study of whom 62 had a partial articular-sided tear. Those with a partial articular-sided tear were older (P=0.0001, were more commonly associated with a documented injury (P=0.03, and more commonly had biceps degeneration (P=0.001 and synovitis (P=0.02 within the joint. Conclusion: Partial-thickness articular-sided tears are a common occurrence in patients requiring arthroscopic surgery for rotator cuff pathology over the age of 35 years. This probably reflects an injury in an already degenerate cuff. This would support the theory of intrinsic degeneration of the tendon in this age group and probably represent a different etiology to those seen in the young athletes. Level of Evidence: Level 3

  5. Tratamiento del dolor en la artritis reumatoide fundamentado en medicina basada en la evidencia Pain treatment in rheumatoid arthritis and evidence-based medicine

    Directory of Open Access Journals (Sweden)

    F. Neira

    2006-11-01

    , ciclosporina, sales de oro, azatioprina, infliximab, leflunomida y ciclofosfamida. La combinación de uno o más son eficaces y no más tóxicos que por separado. Los glucocorticoides a dosis bajas disminuyen la evolución del daño articular, no deben ser recomendados de rutina (R B. La infiltración articular con corticoides puede ser útil en el tratamiento de la AR. Se utiliza concomitantemente la administración de calcio, vitamina D y bifosfonatos (R B. El tratamiento quirúrgico está indicado cuando el dolor no mejora con medidas médicas y hay pérdida de función. Entre las complicaciones de la AR se encuentran: síndrome del túnel del carpo, vasculitis reumatoide, ataque de la región cervical y artritis séptica. No se deben olvidar las medidas nutricionales, terapia ocupacional (NE I, ejercicios, protección de las articulaciones y psicoterapia (NE I.The objective has been the elaboration of a practical document, based on the best available scientific evidence, that allows physicians to adopt adequately founded diagnostic techniques and effective treatment in Rheumatoid Arthritis (RA. A systematic search in Internet has been made, using the term "rheumatoid arthritis" and "artritis reumatoide", in different groups of elaboration and storage of clinical practice quides: National Guideline Clearinghouse HTTP://www.guideline.gov/compares/compares.aspx, CMA infobase, Primary Care Clinical Practice Guidelines and Fisterra - Directory of Clinical Guides in Spanish. Guides of clinical practice (GPC based in the evidence, meta-analysis and articles of greater relevance have been reviewed. RA is an inflammatory poliarthritis of undetermined aetiology, usually involving peripheral joints, with a symmetrical distribution. It affects functional and work capacity and increases mortality. The usual symptoms are arthralgia, morning stiffness, fatigue, weight loss and fever. It is considered that RA is present when 4 of the following 7 criteria are observed (American Rheumatism

  6. Transcriptional profiling differences for articular cartilage and repair tissue in equine joint surface lesions

    Directory of Open Access Journals (Sweden)

    Stromberg Arnold J

    2009-09-01

    Full Text Available Abstract Background Full-thickness articular cartilage lesions that reach to the subchondral bone yet are restricted to the chondral compartment usually fill with a fibrocartilage-like repair tissue which is structurally and biomechanically compromised relative to normal articular cartilage. The objective of this study was to evaluate transcriptional differences between chondrocytes of normal articular cartilage and repair tissue cells four months post-microfracture. Methods Bilateral one-cm2 full-thickness defects were made in the articular surface of both distal femurs of four adult horses followed by subchondral microfracture. Four months postoperatively, repair tissue from the lesion site and grossly normal articular cartilage from within the same femorotibial joint were collected. Total RNA was isolated from the tissue samples, linearly amplified, and applied to a 9,413-probe set equine-specific cDNA microarray. Eight paired comparisons matched by limb and horse were made with a dye-swap experimental design with validation by histological analyses and quantitative real-time polymerase chain reaction (RT-qPCR. Results Statistical analyses revealed 3,327 (35.3% differentially expressed probe sets. Expression of biomarkers typically associated with normal articular cartilage and fibrocartilage repair tissue corroborate earlier studies. Other changes in gene expression previously unassociated with cartilage repair were also revealed and validated by RT-qPCR. Conclusion The magnitude of divergence in transcriptional profiles between normal chondrocytes and the cells that populate repair tissue reveal substantial functional differences between these two cell populations. At the four-month postoperative time point, the relative deficiency within repair tissue of gene transcripts which typically define articular cartilage indicate that while cells occupying the lesion might be of mesenchymal origin, they have not recapitulated differentiation to

  7. Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage

    OpenAIRE

    Chen, A C; Temple, M.M.; Ng, D.M.; Verzijl, N; de Groot, J.; TeKoppele, J.M.; Sah, R.L.

    2002-01-01

    Objective. To determine whether increasing advanced glycation end products (AGEs) in bovine articular cartilage to levels present in aged human cartilage modulates the tensile biomechanical properties of the tissue. Methods. Adult bovine articular cartilage samples were incubated in a buffer solution with ribose to induce the formation of AGEs or in a control solution. Portions of cartilage samples were assayed for biochemical indices of AGEs and tested to assess their tensile biomechanical p...

  8. Patellar Articular Overlap on MRI Is a Simple Alternative to Conventional Measurements of Patellar Height

    Science.gov (United States)

    Munch, Jacqueline L.; Sullivan, Jaron P.; Nguyen, Joseph T.; Mintz, Douglas; Green, Daniel W.; Shubin Stein, Beth E.; Strickland, Sabrina

    2016-01-01

    Background: Patella alta describes an abnormally high-riding patella in relationship to the femur and has been shown to correlate with patellofemoral pain, instability, chondromalacia, and arthrosis. Conventional measurements of patella alta involve multiple measurements and are often not defined on cross-sectional imaging as related to radiographs. Hypothesis: Patellar articular overlap on sagittal magnetic resonance imaging (MRI) will correlate well with conventional measurements of patella alta as measured by a standardized technique defined by our group. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: MRIs of 239 knees were reviewed by 3 attending surgeons with practices focusing on patellofemoral disease, as well as 2 sports medicine fellows and 1 musculoskeletal radiologist. Measurements included articular overlap, percentage of articular coverage, Caton-Deschamps index, Blackburne-Peel index, and modified Insall-Salvati index. Results: Interrater reliability was high for Caton-Deschamps, Blackburne-Peel, and modified Insall-Salvati indices (intraclass correlation coefficient [ICC], 0.877, 0.828, and 0.787, respectively). Articular overlap and percentage articular coverage correlated well with each other (ICC, 0.961; P < .001) and with the Caton-Deschamps (overlap r = –0.271, P < .001; coverage r = –0.131, P = .037) and Blackburne-Peel (overlap r = 0.343, P < .001; coverage r = –0.238, P < .001) indices. Articular overlap and percentage coverage failed to correlate with the modified Insall-Salvati index (overlap r = –0.117, P = .091; coverage r = 0.007, P = .918). Conclusion: Patellar articular overlap and percentage of patellar articular coverage show promise as a simpler alternative to conventional, ratio-based measurements of patellar height. Future studies are needed to evaluate the range of normal and the relationship to our traditionally used measurements. PMID:27482530

  9. Functional anatomy of the equine temporomandibular joint: Collagen fiber texture of the articular surfaces.

    Science.gov (United States)

    Adams, K; Schulz-Kornas, E; Arzi, B; Failing, K; Vogelsberg, J; Staszyk, C

    2016-11-01

    In the last decade, the equine masticatory apparatus has received much attention. Numerous studies have emphasized the importance of the temporomandibular joint (TMJ) in the functional process of mastication. However, ultrastructural and histological data providing a basis for biomechanical and histopathological considerations are not available. The aim of the present study was to analyze the architecture of the collagen fiber apparatus in the articular surfaces of the equine TMJ to reveal typical morphological features indicating biomechanical adaptions. Therefore, the collagen fiber alignment was visualized using the split-line technique in 16 adult warmblood horses without any history of TMJ disorders. Within the central two-thirds of the articular surfaces of the articular tubercle, the articular disc and the mandibular head, split-lines ran in a correspondent rostrocaudal direction. In the lateral and medial aspects of these articular surfaces, the split-line pattern varied, displaying curved arrangements in the articular disc and punctual split-lines in the bony components. Mediolateral orientated split-lines were found in the rostral and caudal border of the articular disc and in the mandibular fossa. The complex movements during the equine chewing cycle are likely assigned to different areas of the TMJ. The split-line pattern of the equine TMJ is indicative of a relative movement of the joint components in a preferential rostrocaudal direction which is consigned to the central aspects of the TMJ. The lateral and medial aspects of the articular surfaces provide split-line patterns that indicate movements particularly around a dorsoventral axis.

  10. Diagnosis and management of an intra-articular foreign body in the foot.

    LENUS (Irish Health Repository)

    Mulhall, K J

    2002-10-01

    We describe a case of a small intra-articular foreign body in the foot presenting 48 hours following injury, which at operation showed early evidence of septic arthritis. It is essential to accurately localise periarticular foreign bodies in the foot and proceed to arthrotomy and debridement in all cases where there is radiological or clinical evidence to suggest intra-articular retention of a foreign body.

  11. Anticuerpo anticitrulina y manifestaciones extra articulares en artritis reumatoidea

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    María Jezabel Haye Salinas

    2013-02-01

    Full Text Available Los pacientes con artritis reumatidea (AR pueden desarrollar manifestaciones extra articulares (MExA, relacionadas a su morbi-mortalidad. Los anticuerpos anti-péptidos citrulinados cíclicos (ACCP son específicos para la AR y estan relacionados con el daño articular; y podrían tener rol patogénico en las MExA. Nuestro objetivo fue determinar la relación entre los anticuerpos ACCP y MExA en pacientes con AR. Se incluyeron 74 pacientes con diagnóstico de AR (ACR 1987 mayores de 18 años, de más de 6 meses de evolución, con MExA, y un control apareado por sexo y edad sin MExA por cada paciente. Las variables demográficas, clínicas y de laboratorio se compararon con test t, chi cuadrado o Mann-Whitney. Se realizó análisis multivariado; p ≤ 0.05. Los pacientes con MExA presentaron mayor título de anticuerpo ACCP (116 vs. 34, p < 0.01 y de factor reumatoideo (FR (108 vs. 34.5, p < 0.01. En el análisis multivariado hubo asociación entre la presencia de MExA y tabaquismo activo (p = 0.02, OR: 3.78, IC 95%: 1.17-12.2, FR positivo (p = 0.04, OR: 3.23, IC95%: 1.04-11.8 y anticuerpo ACCP positivo (p = 0.04, OR: 3.23, IC 95%: 1.04-10. Presentaron mayor título de anticuerpo ACCP que los controles los pacientes con xerostomía (109 vs. 34, p = 0.04, xeroftalmia (150 vs. 34, p < 0.01, nódulos sub-cutáneos (NSC (141 vs. 34, p < 0.01 y fibrosis pulmonar (158 vs. 34, p = 0.04. En conclusión, el anticuerpo ACCP positivo, el FR positivo y el tabaquismo activo fueron factores de riesgo independientes para el desarrollo de MExA.

  12. Determination of piroxicam from rat articular tissue and plasma based on LC-MS/MS.

    Science.gov (United States)

    Kim, Han Sol; Cho, Ha Ra; Ho, Myoung Jin; Kang, Myung Joo; Choi, Yong Seok

    2016-12-01

    Osteoarthritis (OA) is the most common type of arthritis. To manage OA, in general, oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) is used. Recently, the analgesic and anti-inflammatory efficacy of piroxicam (PX), a long-acting NSAID, by intra-articular (IA) administration in OA was reported, and the possibility that PX is distributed in articular tissues at a certain concentration was raised. Thus, herein, novel LC-MS/MS methods to detect PX in rat articular tissue and plasma are presented. For articular tissue, solvent extraction with acetonitrile for 12 h was employed and a protein precipitation method was used for the preparation of a plasma sample. The developed methods were validated by following the FDA guidelines, and the validated methods were successfully applied to a PK study of IA PX. The present study presents, to our knowledge, the first method of determining a drug in articular tissue. Additionally, the level of PX in articular tissue after IA PX administration was experimentally confirmed for the first time using the present methods. Therefore, the present methods provide a new direction for in vivo evaluation for IA PX formulations and contribute to the development of alternative IA PX formulations with better effects for the treatment of OA.

  13. Human Adipose-Derived Mesenchymal Progenitor Cells Engraft into Rabbit Articular Cartilage

    Directory of Open Access Journals (Sweden)

    Wen Wang

    2015-05-01

    Full Text Available Mesenchymal stem cells (MSCs are known to have the potential for articular cartilage regeneration, and are suggested for the treatment of osteoarthritis (OA. Here, we investigated whether intra-articular injection of xenogeneic human adipose-derived mesenchymal progenitor cells (haMPCs promoted articular cartilage repair in rabbit OA model and engrafted into rabbit articular cartilage. The haMPCs were cultured in vitro, and phenotypes and differentiation characteristics of cells were evaluated. OA was induced surgically by anterior cruciate ligament transection (ACLT and medical meniscectomy of knee joints. At six weeks following surgery, hyaluronic acid (HA or haMPCs was injected into the knee joints, the contralateral knee served as normal control. All animals were sacrificed at the 16th week post-surgery. Assessments were carried out by macroscopic examination, hematoxylin/eosin (HE and Safranin-O/Fast green stainings and immunohistochemistry. The data showed that haMPC treatment promoted cartilage repair. Signals of human mitochondrial can be directly detected in haMPC treated cartilage. The haMPCs expressed human leukocyte antigen I (HLA-I but not HLA-II-DR in vivo. These results suggest that intra-articular injection of haMPCs promotes regeneration of articular cartilage in rabbit OA model, and support the notion that MPCs are transplantable between HLA-incompatible individuals.

  14. Asociación entre porphyromona gingivalis y proteína C reactiva en enfermedades sistémicas inflamatorias Association between porphyromonas gingivalis and C-reactive protein in systemic inflammatory diseases

    OpenAIRE

    C.M. Ardila Medina; G.I. Lafaurie Villamil

    2010-01-01

    La proteína C reactiva (PCR) es un marcador serológico de la inflamación asociado con incremento en el riesgo de enfermedades sistémicas inflamatorias (ESI). La periodontitis también se relaciona con niveles elevados de PCR en adultos y con una reducción de la misma después de su tratamiento. Así, se ha postulado que la PCR puede ser un posible mediador de la asociación entre periodontitis y ESI. Los patógenos periodontales además de inducir inflamación local y destrucción tisular están invol...

  15. Tribology approach to the engineering and study of articular cartilage.

    Science.gov (United States)

    Wimmer, Markus A; Grad, Sibylle; Kaup, Thomas; Hänni, Markus; Schneider, Erich; Gogolewski, Sylwester; Alini, Mauro

    2004-01-01

    This study has been based on the assumption that articular motion is an important aspect of mechanotransduction in synovial joints. For this reason a new bioreactor concept, able to reproduce joint kinematics more closely, has been designed. The prototype consists of a rotating scaffold and/or cartilage pin, which is pressed onto an orthogonally rotating ball. By oscillating pin and ball in phase difference, elliptical displacement trajectories are generated that are similar to the motion paths occurring in vivo. Simultaneously, dynamic compression may be applied with a linear actuator, while two-step-motors generate the rotation of pin and ball. The whole apparatus is placed in an incubator. The control station is located outside. Preliminary investigations at the gene expression level demonstrated promising results. Compared with free-swelling control and/or simply compression-loaded samples, chondrocyte-seeded scaffolds as well as nasal cartilage explants exposed to interface motion both showed elevated levels of cartilage oligomeric matrix protein mRNA. The final design of the bioreactor will include four individual stations in line, which will facilitate the investigation of motion-initiated effects at the contacting surfaces in more detail.

  16. Study of cryopreservation of articular chondrocytes using the Taguchi method.

    Science.gov (United States)

    Lyu, Shaw-Ruey; Wu, Wei Te; Hou, Chien Chih; Hsieh, Wen-Hsin

    2010-04-01

    This study evaluates the effect of control factors on cryopreservation of articular cartilage chondrocytes using the Taguchi method. Freeze-thaw experiments based on the L(8)(2(7)) two-level orthogonal array of the Taguchi method are conducted, and ANOVA (analysis of variables) is adopted to determine the statistically significant control factors that affect the viability of the cell. Results show that the type of cryoprotectant, freezing rate, thawing rate, and concentration of cryoprotectant (listed in the order of influence) are the statistically significant control factors that affect the post-thaw viability. The end temperature and durations of the first and second stages of freezing do not affect the post-thaw viability. Within the ranges of the control factors studied in this work, the optimal test condition is found to be a freezing rate of 0.61+/-0.03 degrees C/min, a thawing rate of 126.84+/-5.57 degrees C/min, Me(2)SO cryoprotectant, and a cryoprotectant concentration of 10% (v/v) for maximum cell viability. In addition, this study also explores the effect of cryopreservation on the expression of type II collagen using immunocytochemical staining and digital image processing. The results show that the ability of cryopreserved chondrocytes to express type II collagen is reduced within the first five days of monolayer culture.

  17. Intracortical chondroblastoma mimicking intra-articular osteoid osteoma

    Energy Technology Data Exchange (ETDEWEB)

    Ishida, Tsuyoshi; Mukai, Kiyoshi [First Department of Pathology, Tokyo Medical University, Shinjuku 6-1-1, Shinjuku-ku, Tokyo 160-8402 (Japan); Goto, Takahiro [Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo (Japan); Motoi, Noriko [Department of Pathology, Toranomon Hospital, Tokyo (Japan)

    2002-10-01

    We report a case of intra-articular intracortical chondroblastoma of the femoral condyle which radiologically appeared to be osteoid osteoma. A 19-year-old woman presented with a 3-year history of gradually increasing pain in the right knee and had been on nonsteroidal anti-inflammatory drugs for pain relief. Laboratory data were within normal limits. Radiographs showed a well-demarcated lucent lesion in the medial condyle of the right femur. A nidus-like lesion with calcifications and a sclerotic rim located in the cortex was imaged by computed tomography scan. Magnetic resonance imaging revealed bone marrow edema and soft tissue swelling around the lesion, with low signal intensity of the nidus-like lesion on both T1- and T2-weighted images. The lesion was excised en bloc and the histological diagnosis of chondroblastoma was made. A mild inflammatory reaction was observed in the bone marrow and synovium around the tumor. The chondroblastoma cells were shown to express cyclooxygenase-2 with immunohistochemistry. (orig.)

  18. A study of crystalline biomaterials for articular cartilage bioengineering

    Energy Technology Data Exchange (ETDEWEB)

    Gross-Aviv, Talia [Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer Sheva, 84105 (Israel)], E-mail: taliag@bgu.ac.il; DiCarlo, Bryan B. [Department of Bioengineering, Rice University, Houston, TX 77003 (United States)], E-mail: bdicarlo@rice.edu; French, Margaret M. [Department of Bioengineering, Rice University, Houston, TX 77003 (United States)], E-mail: mmfrench@rice.edu; Athanasiou, Kyriacos A. [Department of Bioengineering, Rice University, Houston, TX 77003 (United States)], E-mail: athanasiou@rice.edu; Vago, Razi [Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer Sheva, 84105 (Israel)], E-mail: rvago@bgu.ac.il

    2008-12-01

    This study examines the suitability of marine origin coral species, Porites lutea (POR) and the hydrozoan Millepora dichotoma (MIL), for use as novel three dimensional growth matrices in the field of articular cartilage tissue engineering. Therefore, mesenchymal stem cells (MSCs) and chondrocytes were grown on the skeletal material obtained from each of these two organisms to investigate their potential use as three dimensional scaffolding for cartilage tissue growth. Chondrogenic induction of MSCs was achieved by addition of transforming growth factor-{beta}1 (TGF-{beta}1) and insulin growth factor-I (IGF-I). Cell adherence, proliferation, differentiation and tissue development were investigated through six weeks of culture. Cartilage tissue growth and chondrocytic phenotype maintenance of each cell type were examined by cell morphology, histochemical analyses, expression of collagen type II and quantitative measures of glycosaminoglycan (GAG) content. The MSCs and the chondrocytes were shown good adherence to the scaffolds and maintenance of the chondrocytic phenotype in the initial stages of culture. However after two weeks of culture on MIL and three weeks on POR these cultures began to exhibit signs of further differentiation and phenotypic loss. The shown results indicated that POR was a better substrate for chondrocytes phenotype maintenance than MIL. We believe that surface modification of POR combined with mechanical stimuli will provide a suitable environment for chondrogenic phenotype maintenance. Further investigation of POR and other novel coralline biomatrices is indicated and warranted in the field of cartilage tissue engineering applications.

  19. Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage

    Directory of Open Access Journals (Sweden)

    Charlotte M. Beddoes

    2016-06-01

    Full Text Available Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are used. This results in undesirable side effects, including inadequate lubrication, wear debris, wear of the opposing articular cartilage, and weakening of the surrounding tissue. With the number of surgeries for cartilage repair increasing, a need for materials that can better mimic cartilage, and support the surrounding material in its typical function, is becoming evident. Here, we present a brief overview of the structure and properties of the hyaline cartilage and the current methods for cartilage repair. We then highlight some of the alternative materials under development as potential methods of repair; this is followed by an overview of the development of tough hydrogels. In particular, double network (DN hydrogels are a promising replacement material, with continually improving physical properties. These hydrogels are coming closer to replicating the strength and toughness of the hyaline cartilage, while offering excellent lubrication. We conclude by highlighting several different methods of integrating replacement materials with the native joint to ensure stability and optimal behaviour.

  20. Bilateral Intra-Articular Radiofrequency Ablation for Cervicogenic Headache

    Science.gov (United States)

    Tang, Teresa; Taftian, David; Chhatre, Akhil

    2017-01-01

    Introduction. Cervicogenic headache is characterized by unilateral neck or face pain referred from various structures such as the cervical joints and intervertebral disks. A recent study of patients with cervical pain showed significant pain relief after cervical medial branch neurotomy but excluded patients with C1-2 joint pain. It remains unclear whether targeting this joint has potential for symptomatic relief. To address this issue, we present a case report of C1-2 joint ablation with positive outcomes. Case Presentation. A 27-year-old female presented with worsening cervicogenic headache. Her pain was 9/10 by visual analog scale (VAS) and described as cramping and aching. Pain was localized suboccipitally with radiation to her jaw and posterior neck, worse on the right. Associated symptoms included clicking of her temporomandibular joint, neck stiffness, bilateral headaches with periorbital pain, numbness, and tingling. History, physical exam, and diagnostic studies indicated localization to the C1-2 joint with 80% decrease in pain after C1-2 diagnostic blocks. She underwent bilateral intra-articular radiofrequency ablation of the C1-C2 joint. Follow-up at 2, 4, 8, and 12 weeks showed improved function and pain relief with peak results at 12 weeks. Conclusion. Clinicians may consider C1-C2 joint ablation as a viable long-term treatment option for cervicogenic headaches. PMID:28149652

  1. Spectrocolorimetric evaluation of repaired articular cartilage after a microfracture

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    Dohi Yoshihiro

    2008-09-01

    Full Text Available Abstract Background In clinical practice, surgeons differentiate color changes in repaired cartilage compared with surrounding intact cartilage, but cannot quantify these color changes. Objective assessments are required. A spectrocolorimeter was used to evaluate whether intact and repaired cartilage can be quantified. Findings We investigated the use of a spectrocolorimeter and the application of two color models (L* a* b* colorimetric system and spectral reflectance distribution to describe and quantify articular cartilage. In this study, we measured the colors of intact and repaired cartilage after a microfracture. Histologically, the repaired cartilage was a mixture of fibrocartilage and hyaline cartilage. In the L* a* b* colorimetric system, the L* and a* values recovered to close to the values of intact cartilage, whereas the b* value decreased over time after the operation. Regarding the spectral reflectance distribution at 12 weeks after the operation, the repaired cartilage had a higher spectral reflectance ratio than intact cartilage between wavelengths of 400 to 470 nm. Conclusion This study reports the first results regarding the relationship between spectrocolorimetric evaluation and the histological findings of repair cartilage after a microfracture. Our findings demonstrate the ability of spectrocolorimetric measurement to judge the repair cartilage after treatment on the basis of objective data such as the L*, a* and b* values and the SRP as a coincidence index of the spectral reflectance curve.

  2. Early Intra-Articular Complement Activation in Ankle Fractures

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    Hagen Schmal

    2014-01-01

    Full Text Available Cytokine regulation possibly influences long term outcome following ankle fractures, but little is known about synovial fracture biochemistry. Eight patients with an ankle dislocation fracture were included in a prospective case series and matched with patients suffering from grade 2 osteochondritis dissecans (OCD of the ankle. All fractures needed external fixation during which joint effusions were collected. Fluid analysis was done by ELISA measuring aggrecan, bFGF, IL-1β, IGF-1, and the complement components C3a, C5a, and C5b-9. The time periods between occurrence of fracture and collection of effusion were only significantly associated with synovial aggrecan and C5b-9 levels (P<0.001. Furthermore, synovial expressions of both proteins correlated with each other (P<0.001. Although IL-1β expression was relatively low, intra-articular levels correlated with C5a (P<0.01 and serological C-reactive protein concentrations 2 days after surgery (P<0.05. Joint effusions were initially dominated by neutrophils, but the portion of monocytes constantly increased reaching 50% at day 6 after fracture (P<0.02. Whereas aggrecan and IL-1β concentrations were not different in fracture and OCD patients, bFGF, IGF-1, and all complement components were significantly higher concentrated in ankle joints with fractures (P<0.01. Complement activation and inflammatory cell infiltration characterize the joint biology following acute ankle fractures.

  3. Efectos del tratamiento con anti-TNF-α, infliximab, sobre la resistencia insulínica, adipocinas (visfatina, leptina, adiponectina, resistina y apelina) y angiopoyetina-2 en pacientes con espondilitis anquilosante

    OpenAIRE

    Miranda Filloy, José Alberto

    2014-01-01

    RESUMEN: La Espondilitis Anquilosante (EA) es una enfermedad inflamatoria crónica que afecta fundamentalmente a la columna vertebral produciendo sacroileítis. Estos pacientes presentan una aterogénesis acelerada y resistencia insulínica, lo que favorece la disfunción endotelial e incrementa el riesgo cardiovascular. Hemos documentado que la infusión del anti-TNF-α infliximab en pacientes no diabéticos con EA mejora la sensibilidad insulínica y disminuye las concentraciones séricas de angio...

  4. The opinion of patients with inflammatory bowel disease on healthcare received Opinión de los pacientes con enfermedad inflamatoria intestinal sobre la atención sanitaria recibida

    Directory of Open Access Journals (Sweden)

    F. Casellas

    2004-03-01

    information, care of family members, and healthcare resources accessibility/agility.Fundamento: un elemento a tener en cuenta al analizar un modelo de atención sanitaria dirigido a un grupo de población afecta de una enfermedad crónica es el de los recursos sanitarios necesarios, su utilización y la valoración que tienen los usuarios de ellos. En la enfermedad inflamatoria intestinal (EII los recursos sanitarios utilizados por los enfermos son numerosos y variados, pero no han sido evaluados. Diseño: se ha realizado una encuesta autorrellenable anónima de 24 preguntas básicas a cerca de datos generales de la enfermedad, quién les controla, cómo se programan las visitas, necesidad de atención urgente, cómo creen que se puede mejorar su control, etc. La encuesta se remitió al domicilio de 393 pacientes para su contestación y se les pidió que la devolvieran por correo. Resultados: doscientos treinta y siete pacientes devolvieron la encuesta cumplimentada. La mayoría de los pacientes eran controlados en un hospital, y sólo el 8,8% lo eran por el médico de cabecera o especialista de zona. El 92% de pacientes refieren que las visitas se programan de forma rutinaria, independientemente del estado clínico. El 79,6% de pacientes refiere haber acudido alguna vez a urgencias, siendo el motivo en el 25,2% de las ocasiones no saber qué hacer o no tener otro recurso disponible. Ello explica que el 38% de visitas al servicio de urgencias se podrían haber evitado con un mejor conocimiento de la enfermedad o una consulta telefónica. El 30% de pacientes refiere que la actual atención sanitaria es inadecuada, ya sea por su contenido, la forma o el tiempo de espera. El 97,8% de pacientes cree que la información y conocimiento de la enfermedad ayudarían a su control, de forma que el 69,6% considera que con la información adecuada podrían iniciar el tratamiento ya antes de la visita médica. Otro aspecto poco atendido, y que el 74,6% de pacientes opina que ayudaría al

  5. Avaliação microbiológica e molecular de líquidos articulares e peri-articulares de suínos

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    Ana Carolina S. Faria

    2011-08-01

    Full Text Available No presente estudo coletaram-se 115 amostras de líquido articular e peri-articular de suínos com suspeita clínica de doença articular oriundos de maternidade (30,43%, creche (44,35% e crescimento/terminação (25,22% de Sistemas Intensivos de Produção de Suínos (SIPs para avaliação microbiológica e molecular. Observaram-se 57 (49,5% amostras positivas em pelo menos uma das técnicas. No isolamento microbiano, 39,13% das amostras foram positivas, sendo Streptococcus spp. (19,72%, Arcabobacterium pyogenes (18,13% e Escherichia coli (12,68% os mais frequentes, havendo também a presença de Candida sp. (2,6%. Na técnica de Reação em Cadeia da Polimerase (PCR, em 20% das amostras foram detectados microrganismos com uma maior ocorrência de Mycoplasma hyosinoviae (34,09%, Erysipelotrix tonsilarum (20,45% e Haemophilus parasuis (15,90%. Os microrganismos mais frequentemente isolados em animais com artrite, apresentaram distribuição em todas as faixas etárias, entretanto a fase de crescimento/terminação apresentou maior percentual (69% de amostras positivas. Streptococcus spp. ocorreu em todas as fases sendo o microrganismo mais detectado. M. hyosinoviae foi observado principalmente em animais de creche. Na fase de crescimento/terminação as bactérias predominantes foram A. pyogenes, H. parasuis e E. tonsilarum. Aproximadamente metade dos casos foi negativo o que indica a provável ocorrência de processos degenerativos como a osteocondrose, embora a participação de infecções articulares e peri-articulares possam representar grandes perdas com menor ou maior impacto dependendo da fase de criação. Problemas articulares e/ou peri-articulares de origem infecciosas foram encontrados em todas as propriedades estudadas. O principal agente foi M. hyosynoviae, principalmente na creche, porém não se pode descartar o envolvimento de problemas degenerativos em associação.

  6. Usefulness of fluoroscopy-guided intra-articular injection of the knee

    Energy Technology Data Exchange (ETDEWEB)

    Myung, Jae Sung; Lee, Joon Woo [Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Lee, Ji Yeon [Kangwon National University College of Medicine, Chuncheon (Korea, Republic of)] (and others)

    2007-06-15

    To determine the accuracy of the intra-articular location of hyaluronic acid injection using a blind approach and to establish the usefulness of fluoroscopy-guided intra-articular injection. A fluoroscopy unit was used for 368 intra-articular injections of hyaluronic acid to 93 knees in 65 patients. Initially, blind needle positioning was conducted on the fluoroscopy table. The failure rate of the blind approach among the 368 injections was evaluated, and a relationship between the Kellgren-Lawrence grade (K-L grade) and the incidence of repeated failures using the blind approach was determined for injections to 52 knees in 37 patients who received a complete cycle of injections (five consecutive injections with a one-week interval between injections). Using a blind approach, 298 of 368 trials (81.2%) resulted in a needle tip being placed in an intra-articular location, while 70 of 368 trials resulted in an extra-articular placement of the needle tip. Among 52 knees to which a complete cycle of injection (five consecutive injections with a one-week interval between injections) was administered, repeated failure of intra-articular placement using the blind approach was seen for 18 knees (34.6%); a more severe K-L grade assigned was associated with a higher rate of repeated failure. However, the trend was not statistically significant based on the Chi-squared test ({rho} value = 0.14). Fluoroscopy-guided needle placement may be helpful to ensure therapeutic intra-articular injection of the knee.

  7. Effects of freezing rates and cryoprotectant on thermal expansion of articular cartilage during freezing process.

    Science.gov (United States)

    Xu, Y; Sun, H J; Lv, Y; Zou, J C; Lin, B L; Hua, T C

    2013-01-01

    The intact articular cartilage has not yet been successfully preserved at low temperature most likely due to the volume expansion from water to ice during freezing. The objective of this current study focuses on examining thermal expansion behavior of articular cartilage (AC) during freezing from 0 degree C to -100 degree C. Thermo Mechanical Analysis (TMA) was used to investigate the effects of different concentrations of dimethyl sulphoxide (DMSO) (0%, 10%, 30% and 60% v/v) and different freezing rates (1 C/min, 3 C/min and 5 C/min). The results showed that: (1) the inhomogeneous thermal expansion (or contraction) presents due to inhomogeneous water distributions in articular cartilage during freezing, which also may be the most likely reason that the matrix has been damaged in cryopreserved intact articular cartilage; (2) at the phase transition temperature range, the maximum thermal strain change value for 5C/min is approximately 1.45 times than that for 1 C/min, but the maximum thermal expansion coefficient of the later is about six times than that of the former; (3) the thermal expansion coefficient decreases with increasing cooling rate at the unfrozen temperature region, but some opposite results are obtained at the frozen temperature region; (4) the higher the DMSO concentration is, at the phase change temperature region, the smaller the thermal strain change as well as the maximum thermal expansion coefficient are, but DMSO concentration exhibits little effect on the thermal expansion coefficient at both unfrozen and frozen region. Once the DMSO concentration increasing enough, e.g. 60% v/v, the thermal strain decreases linearly and smoothly without any abrupt change due to little or no ice crystal forms (i.e. vitrification) in frozen articular cartilage. This study may improve our understanding of the thermal expansion (or contraction) behavior of cryopreserved articular cartilage and it may be useful for the future study on cryopreservation of intact

  8. OPERATIVE MANAGEMENT OF INTRA-ARTICULAR DISTAL HUMERAL FRACTURES WITH LOCKING PLATES

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    Abhilekh

    2015-11-01

    Full Text Available BACKGROUND: Intra-articular distal humeral fractures are common, but complex elbow injuries. To obtain good results, anatomical reduction with rigid fixation and early range of mobilization is required. Treatment of these fractures with conventional plates is associated with many complications such as non-anatomic reduction of articular surfaces, malunion, non-union, loosening of implant, residual stiffness of the elbow and post-traumatic osteoarthrosis. In this situation the application of locking plates having a fixed angle plate screw construct can minimise most of the above complications. OBJECTIVE: To evaluate radiological and functional outcome of locking plate application for the management of intra-articular distal humeral fractures. MATERIAL AND METHODS: This prospective study was conducted from January 2013 to December 2014. We operated 20 patients of AO type-C intra-articular distal humeral fractures. Fracture was exposed using modified Campbell’s posterior approach in less comminuted fractures and a V-shaped Olecranon osteotomy was done to get better exposure of the articular surface in cases with severe articular comminution. The fracture was stabilized using an intercondylar screw, pre-contoured locking compression plates and/or locking reconstruction plates as per preoperative planning. Patients were reviewed at monthly interval for clinical-radiological evaluation. Final outcome measures included radiological assessment, range of motion and Mayo elbow performance score (MEPS. RESULTS: All the fractures were united at an average 12 weeks. Two patients developed numbness in the distribution of ulnar nerve and one patient developed superficial infection in immediate postoperative period. None of the patients had malunion and loosening of implant. The average arc of flexion-extension was 105`, although no patient had loss of supination/pronation. Mayo Elbow Performance Score was excellent in 15 (75%, good in 3 (15%, fair in 1 (5

  9. Efecto de las cargas articulares sobre el flujo y pH salival Effect of TMJ loading on salivary flow and pH

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    RJ Castro

    2011-04-01

    Full Text Available Una alteración del flujo salival es clave en el desarrollo de caries, enfermedad periodontal e infecciones oportunistas. El flujo salival está determinado por diversos estímulos que actúan sobre receptores de distinta naturaleza, entre ellos mecanoreceptores articulares. Algunos estudios demuestran que las cargas articulares actúan sobre estos receptores, modificando cualitativa y cuantitativamente la secreción salival. El objetivo de este estudio fue determinar si existe una relación entre la aplicación controlada de cargas articulares y cambios en el flujo y pH salival. 30 voluntarios fueron seleccionados según criterios de inclusión establecidos. Se elaboró un dispositivo interoclusal que en relación a piezas 1.5 y 2.5, tenía botones acrílicos de 1 mm de espesor, los que al ejercer fuerzas sobre ellos provocan cargas reversibles sobre la ATM. Antes de usar el dispositivo, en cada individuo se midió flujo salival no estimulado (FSNE el flujo salival estimulado (FSE y el pH de ambos. Tras un periodo de adaptación diaria por una semana, cada participante usó el dispositivo durante 1 hora, ejerciendo fuerza masticatoria sostenida. Luego se midieron ambos flujos y el pH correspondiente. El procedimiento fue repetido por 7 días, bajo supervisión. No se observó una relación aparente entre la aplicación controlada de cargas articulares y cambios volumétricos de flujo salival. Las mujeres tuvieron un FSE y FSNE menor al de los hombres. La aplicación de sobrecargas articulares por un breve período de tiempo provoca una caída del pH del FSE luego de 3 días de aplicación.Altered salivary flow is key for the onset of dental caries, periodontal disease and opportunistic infections. Salivary flow is determined by various stimuli on several receptors, including joint mechanoreceptors. Some studies show that loads on the TMJ affect these receptors causing changes on the quality and quantity of saliva secretion. The aim of this

  10. Arthroscopic laser in intra-articular knee cartilage disorders

    Science.gov (United States)

    Nosir, Hany R.; Siebert, Werner E.

    1996-12-01

    Different assemblies have endeavored to develop arthroscopic laser surgery. Various lasers have been tried in the treatment of orthopaedic problems, and the most useful has turned out to be the Hol-YAG laser 2.1 nm which is a near- contact laser. By using the laser as a powerful tool, and cutting back on the power level, one is able to better achieve the desired treatment effect. Clinical studies to evaluating the role of the laser in different arthroscopic knee procedures, comparing to conventional techniques, showed that the overall outcome attains a momentous confidence level which is shifted to the side of the laser versus the conventional for all maneuvers, barring meniscectomy where there is not perceiving disparity between laser versus the conventional. Meniscectomy continues to be one of the most commonly performed orthopaedic procedures. Laser provides a single tool which can ablate and debride meniscal rims with efficiency and safety. Chondroplasty can also be accomplished with ease using defocused laser energy. Both lateral release and soft tissue cermilization benefit from the cutting effect of laser along with its hemostatic effect. Synovial reduction with a defocused laser is also easily accomplished. By one gadget, one can cut, ablate, smooth, coagulate, congeal and with authentic tissue depth control The future of laser arthroscopic surgery lies in its ability to weld or repair tissues. Our research study has shown that laser activated photoactive dyes can produce a molecular bonding of collagen fibers, and therefore a repair 'weld' can be achieved with both meniscal tissues and with articular cartilage lesions.

  11. Serum-free media for articular chondrocytes in vitro expansion

    Institute of Scientific and Technical Information of China (English)

    SHAO Xin-xin; Neil A.Duncan; LIN Lin; FU Xin; ZHANG Ji-ying; YU Chang-long

    2013-01-01

    Background In vitro chondrocyte expansion is a major challenge in cell-based therapy for human articular cartilage repair.Classical culture conditions usually use animal serum as a medium supplement,which raises a number of undesirable questions.In the present study,two kinds of defined,serum-free media were developed to expand chondrocytes in monolayer culture for the purpose of cartilage tissue engineering.Methods Bovine chondrocytes were expanded in serum-free media supplemented with fibroblast growth factor-2 and platelet-derived growth factor or fibroblast growth factor-2 and insulin-like growth factor.Expansion culture in a conventional 10% fetal bovine serum (FBS) medium served as control.Fibronectin coating was used to help cell adhesion in serum-free medium.Next,in vitro three-dimensional pellet culture was used to evaluate the chondrocyte capacity.Cell pellets were expanded in different media to re-express the differentiated phenotype (re-differentiation) and to form cartilaginous tissue.The pellets were assessed by glycosaminoglycans contents,collagen II,collagen I and collagen X immunohistological staining.Results Chondrocytes cultured in serum-free media showed no proliferation difference than cells grown with 10% FBS medium.In addition,chondrocytes expanded in both serum-free media expressed more differentiated phenotypes at the end of monolayer culture,as indicated by higher gene expression ratios of collagen type Ⅱ to collagen type Ⅰ.Pellets derived from chondrocytes cultured in both serum-free media displayed comparable chondrogenic capacities to pellets from cells expanded in 10% FBS medium.Conclusion These findings provide alternative culture approaches for chondrocytes in vitro expansion,which may benefit the clinical use of autologous chondrocytes implantation.

  12. Lubrication mode analysis of articular cartilage using Stribeck surfaces.

    Science.gov (United States)

    Gleghorn, Jason P; Bonassar, Lawrence J

    2008-01-01

    Lubrication of articular cartilage occurs in distinct modes with various structural and biomolecular mechanisms contributing to the low-friction properties of natural joints. In order to elucidate relative contributions of these factors in normal and diseased tissues, determination and control of lubrication mode must occur. The objectives of these studies were (1) to develop an in vitro cartilage on glass test system to measure friction coefficient, mu; (2) to implement and extend a framework for the determination of cartilage lubrication modes; and (3) to determine the effects of synovial fluid on mu and lubrication mode transitions. Patellofemoral groove cartilage was linearly oscillated against glass under varying magnitudes of compressive strain utilizing phosphate buffered saline (PBS) and equine and bovine synovial fluid as lubricants. The time-dependent frictional properties were measured to determine the lubricant type and strain magnitude dependence for the initial friction coefficient (mu(0)=mu(t-->0)) and equilibrium friction coefficient (mu(eq)=mu(t-->infinity)). Parameters including tissue-glass co-planarity, normal strain, and surface speed were altered to determine the effect of the parameters on lubrication mode via a 'Stribeck surface'. Using this testing apparatus, cartilage exhibited biphasic lubrication with significant influence of strain magnitude on mu(0) and minimal influence on mu(eq), consistent with hydrostatic pressurization as reported by others. Lubrication analysis using 'Stribeck surfaces' demonstrated clear regions of boundary and mixed modes, but hydrodynamic or full film lubrication was not observed even at the highest speed (50mm/s) and lowest strain (5%).

  13. Adaptive mechanically controlled lubrication mechanism found in articular joints.

    Science.gov (United States)

    Greene, George W; Banquy, Xavier; Lee, Dong Woog; Lowrey, Daniel D; Yu, Jing; Israelachvili, Jacob N

    2011-03-29

    Articular cartilage is a highly efficacious water-based tribological system that is optimized to provide low friction and wear protection at both low and high loads (pressures) and sliding velocities that must last over a lifetime. Although many different lubrication mechanisms have been proposed, it is becoming increasingly apparent that the tribological performance of cartilage cannot be attributed to a single mechanism acting alone but on the synergistic action of multiple "modes" of lubrication that are adapted to provide optimum lubrication as the normal loads, shear stresses, and rates change. Hyaluronic acid (HA) is abundant in cartilage and synovial fluid and widely thought to play a principal role in joint lubrication although this role remains unclear. HA is also known to complex readily with the glycoprotein lubricin (LUB) to form a cross-linked network that has also been shown to be critical to the wear prevention mechanism of joints. Friction experiments on porcine cartilage using the surface forces apparatus, and enzymatic digestion, reveal an "adaptive" role for an HA-LUB complex whereby, under compression, nominally free HA diffusing out of the cartilage becomes mechanically, i.e., physically, trapped at the interface by the increasingly constricted collagen pore network. The mechanically trapped HA-LUB complex now acts as an effective (chemically bound) "boundary lubricant"--reducing the friction force slightly but, more importantly, eliminating wear damage to the rubbing/shearing surfaces. This paper focuses on the contribution of HA in cartilage lubrication; however, the system as a whole requires both HA and LUB to function optimally under all conditions.

  14. Binding and lubrication of biomimetic boundary lubricants on articular cartilage.

    Science.gov (United States)

    Samaroo, Kirk J; Tan, Mingchee; Putnam, David; Bonassar, Lawrence J

    2017-03-01

    The glycoprotein, lubricin, is the primary boundary lubricant of articular cartilage and has been shown to prevent cartilage damage after joint injury. In this study, a library of eight bottle-brush copolymers were synthesized to mimic the structure and function of lubricin. Polyethylene glycol (PEG) grafted onto a polyacrylic acid (pAA) core mimicked the hydrophilic mucin-like domain of lubricin, and a thiol terminus anchored the polymers to cartilage surfaces much like lubricin's C-terminus. These copolymers, abbreviated as pAA-g-PEG, rapidly bound to cartilage surfaces with binding time constants ranging from 20 to 39 min, and affected lubrication under boundary mode conditions with coefficients of friction ranging from 0.140 ± 0.024 to 0.248 ± 0.030. Binding and lubrication were highly correlated (r(2)  = 0.89-0.99), showing that boundary lubrication in this case strongly depends on the binding of the lubricant to the surface. Along with time-dependent and dose-dependent behavior, lubrication and binding of the lubricin-mimetics also depended on copolymer structural parameters including pAA backbone length, PEG side chain length, and PEG:AA brush density. Polymers with larger backbone sizes, brush sizes, or brush densities took longer to bind (p lubricate and protect cartilage in vivo. In copolymers with shorter pAA backbones, increasing hydrodynamic size inhibited lubrication (p lubricating efficacy as recombinant lubricins and as such have potential for in vivo treatment of post-traumatic osteoarthritis. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:548-557, 2017.

  15. Cartilage tissue engineering using pre-aggregated human articular chondrocytes

    Directory of Open Access Journals (Sweden)

    F Wolf

    2008-12-01

    Full Text Available In this study, we first aimed at determining whether human articular chondrocytes (HAC proliferate in aggregates in the presence of strong chondrocyte mitogens. We then investigated if the aggregated cells have an enhanced chondrogenic capacity as compared to cells cultured in monolayer. HAC from four donors were cultured in tissue culture dishes either untreated or coated with 1% agarose in the presence of TGFb-1, FGF-2 and PDGF-BB. Proliferation and stage of differentiation were assessed by measuring respectively DNA contents and type II collagen mRNA. Expanded cells were induced to differentiate in pellets or in Hyaff®-11 meshes and the formed tissues were analysed biochemically for glycosaminoglycans (GAG and DNA, and histologically by Safranin O staining. The amount of DNA in aggregate cultures increased significantly from day 2 to day 6 (by 3.2-fold, but did not further increase with additional culture time. Expression of type II collagen mRNA was about two orders of magnitude higher in aggregated HAC as compared to monolayer expanded cells. Pellets generated by aggregated HAC were generally more intensely stained for GAG than those generated by monolayer-expanded cells. Scaffolds seeded with aggregates accumulated more GAG (1.3-fold than scaffolds seeded with monolayer expanded HAC. In conclusion, this study showed that HAC culture in aggregates does not support a relevant degree of expansion. However, aggregation of expanded HAC prior to loading into a porous scaffold enhances the quality of the resulting tissues and could thus be introduced as an intermediate culture phase in the manufacture of engineered cartilage grafts.

  16. Sources of variability in musculo-articular stiffness measurement.

    Science.gov (United States)

    Ditroilo, Massimiliano; Watsford, Mark; Murphy, Aron; De Vito, Giuseppe

    2013-01-01

    The assessment of musculo-articular stiffness (MAS) with the free-oscillation technique is a popular method with a variety of applications. This study examined the sources of variability (load applied and frequency of oscillation) when MAS is assessed. Over two testing occasions, 14 healthy men (27.7±5.2 yr, 1.82±0.04 m, 79.5±8.4 kg) were measured for isometric maximum voluntary contraction and MAS of the knee flexors using submaximal loads relative to the individual's maximum voluntary contraction (MAS%MVC) and a single absolute load (MASABS). As assessment load increased, MAS%MVC (coefficient of variation (CV)  =  8.1-12.1%; standard error of measurement (SEM)  =  51.6-98.8 Nm⁻¹) and frequency (CV  =  4.8-7.0%; SEM  =  0.060-0.075 s⁻¹) variability increased consequently. Further, similar levels of variability arising from load (CV  =  6.7%) and frequency (CV  =  4.8-7.0%) contributed to the overall MAS%MVC variability. The single absolute load condition yielded better reliability scores for MASABS (CV  =  6.5%; SEM  =  40.2 Nm⁻¹) and frequency (CV  =  3.3%; SEM  =  0.039 s⁻¹). Low and constant loads for MAS assessment, which are particularly relevant in the clinical setting, exhibited superior reliability compared to higher loads expressed as a percentage of maximum voluntary contraction, which are more suitable for sporting situations. Appropriate sample size and minimum detectable change can therefore be determined when prospective studies are carried out.

  17. Multi-parametric MRI characterization of enzymatically degraded articular cartilage.

    Science.gov (United States)

    Nissi, Mikko J; Salo, Elli-Noora; Tiitu, Virpi; Liimatainen, Timo; Michaeli, Shalom; Mangia, Silvia; Ellermann, Jutta; Nieminen, Miika T

    2016-07-01

    Several laboratory and rotating frame quantitative MRI parameters were evaluated and compared for detection of changes in articular cartilage following selective enzymatic digestion. Bovine osteochondral specimens were subjected to 44 h incubation in control medium or in collagenase or chondroitinase ABC to induce superficial collagen or proteoglycan (glycosaminoglycan) alterations. The samples were scanned at 9.4 T for T1 , T1 Gd (dGEMRIC), T2 , adiabatic T1 ρ , adiabatic T2 ρ , continuous-wave T1 ρ , TRAFF2 , and T1 sat relaxation times and for magnetization transfer ratio (MTR). For reference, glycosaminoglycan content, collagen fibril orientation and biomechanical properties were determined. Changes primarily in the superficial cartilage were noted after enzymatic degradation. Most of the studied parameters were sensitive to the destruction of collagen network, whereas glycosaminoglycan depletion was detected only by native T1 and T1 Gd relaxation time constants throughout the tissue and by MTR superficially. T1 , adiabatic T1 ρ , adiabatic T2 ρ , continuous-wave T1 ρ , and T1 sat correlated significantly with the biomechanical properties while T1 Gd correlated with glycosaminoglycan staining. The findings indicated that most of the studied MRI parameters were sensitive to both glycosaminoglycan content and collagen network integrity, with changes due to enzymatic treatment detected primarily in the superficial tissue. Strong correlation of T1 , adiabatic T1ρ , adiabatic T2 ρ , continuous-wave T1 ρ , and T1 sat with the altered biomechanical properties, reflects that these parameters were sensitive to critical functional properties of cartilage. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1111-1120, 2016.

  18. Role of computer aided detection (CAD) integration: case study with meniscal and articular cartilage CAD applications

    Science.gov (United States)

    Safdar, Nabile; Ramakrishna, Bharath; Saiprasad, Ganesh; Siddiqui, Khan; Siegel, Eliot

    2008-03-01

    Knee-related injuries involving the meniscal or articular cartilage are common and require accurate diagnosis and surgical intervention when appropriate. With proper techniques and experience, confidence in detection of meniscal tears and articular cartilage abnormalities can be quite high. However, for radiologists without musculoskeletal training, diagnosis of such abnormalities can be challenging. In this paper, the potential of improving diagnosis through integration of computer-aided detection (CAD) algorithms for automatic detection of meniscal tears and articular cartilage injuries of the knees is studied. An integrated approach in which the results of algorithms evaluating either meniscal tears or articular cartilage injuries provide feedback to each other is believed to improve the diagnostic accuracy of the individual CAD algorithms due to the known association between abnormalities in these distinct anatomic structures. The correlation between meniscal tears and articular cartilage injuries is exploited to improve the final diagnostic results of the individual algorithms. Preliminary results from the integrated application are encouraging and more comprehensive tests are being planned.

  19. Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.

    Science.gov (United States)

    Sacchetti, Cristiano; Liu-Bryan, Ru; Magrini, Andrea; Rosato, Nicola; Bottini, Nunzio; Bottini, Massimo

    2014-12-23

    Osteoarthritis (OA) is a common and debilitating degenerative disease of articular joints for which no disease-modifying medical therapy is currently available. Inefficient delivery of pharmacologic agents into cartilage-resident chondrocytes after systemic administration has been a limitation to the development of anti-OA medications. Direct intra-articular injection enables delivery of high concentrations of agents in close proximity to chondrocytes; however, the efficacy of this approach is limited by the fast clearance of small molecules and biomacromolecules after injection into the synovial cavity. Coupling of pharmacologic agents with drug delivery systems able to enhance their residence time and cartilage penetration can enhance the effectiveness of intra-articularly injected anti-OA medications. Herein we describe an efficient intra-articular delivery nanosystem based on single-walled carbon nanotubes (SWCNTs) modified with polyethylene glycol (PEG) chains (PEG-SWCNTs). We show that PEG-SWCNTs are capable to persist in the joint cavity for a prolonged time, enter the cartilage matrix, and deliver gene inhibitors into chondrocytes of both healthy and OA mice. PEG-SWCNT nanoparticles did not elicit systemic or local side effects. Our data suggest that PEG-SWCNTs represent a biocompatible and effective nanocarrier for intra-articular delivery of agents to chondrocytes.

  20. X-ray dark field imaging of human articular cartilage: Possible clinical application to orthopedic surgery

    Energy Technology Data Exchange (ETDEWEB)

    Kunisada, Toshiyuki [Department of Medical Materials for Musculoskeletal Reconstruction, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558 (Japan); Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558 (Japan)], E-mail: toshi-kunisada@umin.ac.jp; Shimao, Daisuke [Department of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki 300-2394 (Japan); Sugiyama, Hiroshi [Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Ibaraki 305-0801 (Japan); Takeda, Ken; Ozaki, Toshifumi [Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558 (Japan); Ando, Masami [Research Institute for Science and Technology, Tokyo University of Science, Chiba 278-8510 (Japan)

    2008-12-15

    Despite its convenience and non-invasiveness on daily clinical use, standard X-ray radiography cannot show articular cartilage. We developed a novel type of X-ray dark field imaging (DFI), which forms images only by a refracted beam with very low background illumination. We examined a disarticulated distal femur and a shoulder joint with surrounding soft tissue and skin, both excised from a human cadaver at the BL20B2 synchrotron beamline at SPring-8. The field was 90 mm wide and 90 mm high. Articular cartilage of the disarticulated distal femur was obvious on DFI, but not on standard X-ray images. Furthermore, DFI allowed visualization in situ of articular cartilage of the shoulder while covered with soft tissue and skin. The gross appearance of the articular cartilage on the dissected section of the proximal humerus was identical to the cartilage shown on the DFI image. These results suggested that DFI could provide a clinically accurate method of assessing articular cartilage. Hence, DFI would be a useful imaging tool for diagnosing joint disease such as osteoarthritis.

  1. [Basophilic line of the articular cartilage in normal and various pathological states].

    Science.gov (United States)

    Gongadze, L R

    1987-04-01

    Epiphyses of long tubular bones in the man and animals of various age, as well as experimental material of the adjuvant arthritis, with special reference to the basal part of the articular cartilage have been studied by means of histological, histochemical and histometrical methods. The structural-chemical organization of the basophilic line (tidemark) of the articular cartilage ensures its barrier role and participation in regulating selective permeability. Reconstruction of the tidemark in the process of physiological ageing and in cases of the articular pathology is aimed to preserve its integrity and in this way a complete differentiation of the noncalcified and calcified structures is secured. Disturbance of the basophilic line results in changes of the articular selective permeability, in invasion of vessels and structural elements of the bone marrow, and in development of profound distrophic and destructive changes of the cartilage--in deforming artrosis. Deflations in the structural-chemical organization of the tidemark indicate certain disturbances in the state of the system articular cartilage--subchondral bone. These data can be of prognostic importance.

  2. El área del trabajo del estado peronista frente a las negociaciones colectivas: de la expansión de las capacidades estatales a la ley 14.250

    OpenAIRE

    Luciani, María Paula

    2012-01-01

    Hace ya tiempo que la historiografía ha realizado una reinterpretación del papel del Estado y del propio movimiento obrero de los años ‘30 en cuanto a la capacidad para articular relaciones colectivas en el mundo del trabajo, más allá de los dispositivos de intervención del Estado. Estos estudios desafiaron la imagen rupturista que el peronismo había construido de sí mismo, según la cual las convenciones colectivas como medio de articulación de las relaciones laborales eran una consecuencia d...

  3. Análise da sintomatologia em pacientes com disfunções intra-articulares da articulação temporomandibular Analysis of symptomatology in patients with intra-articular disorders of the temporomandibular joint

    Directory of Open Access Journals (Sweden)

    Sílvio Henrique de Paula DONEGÁ

    1997-01-01

    Full Text Available Foi realizado estudo analisando a sintomatologia em pacientes com disfunções intra-articulares da articulação temporomandibular. A queixa mais citada foi de dor na região pré-auricular (40,7%. Sintomatologia dolorosa articular (63,2% e ruídos articulares (83,3% foram os achados mais comuns ao exame clínico. Os ruídos articulares mais freqüentes foram os estalos (66,6%. Dor muscular ocorreu, em especial, nos músculos pterigóideo medial e lateral e na inserção do temporal. Houve decréscimo na amplitude para a protrusão dentre os movimentos mandibulares máximosThe study analyzed the symptomatology in patients with intra-articular disorders of the temporomandibular joint. The most frequent complaint was pain in the preauricular region (40.7%. Articular pain (63.2% and articular sounds (83.3% were the most common findings during clinical examination. Muscular pain occurred particularly in the medial and lateral pterygoid muscles and at the insertion of the temporalis muscle. The most frequent articular sound was clicking (66.6%. There was a decrease in extent of protrusion among the mandibular border positions.

  4. Necrotizing Faciitis after shoulder mobilization and intra-articular infiltration with betametasone.

    Science.gov (United States)

    Bento-Rodrigues, Joana; Judas, Fernando; Pedrosa Rodrigues, Jorge; Oliveira, João; Simões, Pedro; Lucas, Francisco; Pais Lopes, António

    2013-01-01

    Necrotizing Fasciitis is a rapidly progressive, potentially fatal infection of superficial fasciae and subcutaneous tissue, usually resulting from an inciting trauma to the skin. Medical literature refers few cases of necrotizing fasciitis related to intra-articular infiltrations, that often lead to patients death. This report describes the clinical events on a 55 year-old diabetic patient who developed upper extremity Necrotizing Fasciitis, 18 days after shoulder mobilization and intra-articular infiltration, due to Staphylococcus epidermidis. An early surgical debridement was performed and antibiotherapy was established, resulting in a successful outcome, despite the functional disability. We point out, through this case, the possibility of intra-articular injections of drugs causing Necrotizing Fasciitis, especially in risk patients.

  5. Quantitative characterization of articular cartilage using Mueller matrix imaging and multiphoton microscopy

    Science.gov (United States)

    Ellingsen, Pa˚L. Gunnar; Lilledahl, Magnus Borstad; Aas, Lars Martin Sandvik; Davies, Catharina De Lange; Kildemo, Morten

    2011-11-01

    The collagen meshwork in articular cartilage of chicken knee is characterized using Mueller matrix imaging and multiphoton microscopy. Direction and degree of dispersion of the collagen fibers in the superficial layer are found using a Fourier transform image-analysis technique of the second-harmonic generated image. Mueller matrix images are used to acquire structural data from the intermediate layer of articular cartilage where the collagen fibers are too small to be resolved by optical microscopy, providing a powerful multimodal measurement technique. Furthermore, we show that Mueller matrix imaging provides more information about the tissue compared to standard polarization microscopy. The combination of these techniques can find use in improved diagnosis of diseases in articular cartilage, improved histopathology, and additional information for accurate biomechanical modeling of cartilage.

  6. Extra-Articular Lateral Tenodesis for Anterior Cruciate Ligament Deficient Knee: A Case Report

    Science.gov (United States)

    García-Germán, Diego; Menéndez, Pablo; de la Cuadra, Pablo; Rodríguez-Arozena, Ricardo

    2013-01-01

    We present the case of an extra-articular lateral tenodesis for an anterior cruciate ligament (ACL) deficient knee. A 46-year-old male patient sustained an ACL graft rupture after a motorcycle accident. He complained of rotational instability and giving-way episodes. His previous graft was fixed by an intra-articular femoral staple that was not possible to remove at the time of the ACL revision. A modified Lemaire procedure was then performed. He gained rotational stability and was able to resume his sporting activities. We believe that isolated extra-articular reconstructions may still have a role in selected indications including moderate-demand patients complaining of rotational instability after ACL graft failure. PMID:24369517

  7. Comparison of analgesic effects of intra-articular tenoxicam and morphine in anterior cruciate ligament reconstruction.

    Science.gov (United States)

    Guler, Gulen; Karaoglu, Sinan; Velibasoglu, Hediye; Ramazanogullari, Nesrin; Boyaci, Adem

    2002-07-01

    This study compared the analgesic effect of intra-articular injection of tenoxicam with that of morphine on postoperative pain after anterior cruciate ligament (ACL) reconstruction. Forty-two patients undergoing arthroscopically ACL reconstructions using hamstring tendons underwent the same anesthetic protocol. The patients were randomized to receive 25 ml normal saline, 20 mg tenoxicam in 25 ml normal saline, or 2 mg morphine in 25 ml normal saline. Postoperative pain was assessed using a visual analogue scale and measuring analgesic requirements. We found both that both intra-articular tenoxicam and intra-articular morphine provided better analgesia than that in the control group. Although pain scores were similar between tenoxicam and morphine groups 30 min postoperative, the analgesic requirements in with tenoxicam were significantly lower than those with morphine group 3-6 h postoperatively.

  8. Extra-Articular Lateral Tenodesis for Anterior Cruciate Ligament Deficient Knee: A Case Report

    Directory of Open Access Journals (Sweden)

    Diego García-Germán

    2013-01-01

    Full Text Available We present the case of an extra-articular lateral tenodesis for an anterior cruciate ligament (ACL deficient knee. A 46-year-old male patient sustained an ACL graft rupture after a motorcycle accident. He complained of rotational instability and giving-way episodes. His previous graft was fixed by an intra-articular femoral staple that was not possible to remove at the time of the ACL revision. A modified Lemaire procedure was then performed. He gained rotational stability and was able to resume his sporting activities. We believe that isolated extra-articular reconstructions may still have a role in selected indications including moderate-demand patients complaining of rotational instability after ACL graft failure.

  9. Couple Control Model Implementation on Antagonistic Mono- and Bi-Articular Actuators

    CERN Document Server

    Prattico, Flavio; Yamamoto, Shin-ichiroh

    2014-01-01

    Recently, robot assisted therapy devices are increasingly used for spinal cord injury (SCI) rehabilitation in assisting handicapped patients to regain their impaired movements. Assistive robotic systems may not be able to cure or fully compensate impairments, but it should be able to assist certain impaired functions and ease movements. In this study, a couple control model for lower-limb orthosis of a body weight support gait training system is proposed. The developed leg orthosis implements the use of pneumatic artificial muscle as an actuation system. The pneumatic muscle was arranged antagonistically to form two pair of mono-articular muscles (i.e., hip and knee joints), and a pair of bi-articular actuators (i.e., rectus femoris and hamstring). The results of the proposed couple control model showed that, it was able to simultaneously control the antagonistic mono- and bi-articular actuators and sufficiently performed walking motion of the leg orthosis.

  10. STRUCTURAL ANALYSIS OF ARTICULAR CARTILAGE OF THE HIP JOINT USING FINITE ELEMENT METHOD

    Directory of Open Access Journals (Sweden)

    Robert Karpiński

    2016-09-01

    Full Text Available The paper presents the results of a preliminary study on the structural analysis of the hip joint, taking into account changes in the mechanical properties of the articular cartilage of the joint. Studies have been made due to the need to determine the tension distribution occurring in the cartilage of the human hip. These distribution are the starting point for designing custom made human hip prosthesis. Basic anatomy, biomechanical analysis of the hip joint and articular cartilage are introduced. The mechanical analysis of the hip joint model is conducted. Final results of analysis are presented. Main conclusions of the study are: the capability of absorbing loads by articular cartilage of the hip joint is preliminary determined as decreasing with increasing degenerations of the cartilage and with age of a patient. Without further information on changes of cartilage’s mechanical parameters in time it is hard to determine the nature of relation between mentioned capability and these parameters.

  11. BMP receptor signaling is required for postnatal maintenance of articular cartilage.

    Directory of Open Access Journals (Sweden)

    Ryan B Rountree

    2004-11-01

    Full Text Available Articular cartilage plays an essential role in health and mobility, but is frequently damaged or lost in millions of people that develop arthritis. The molecular mechanisms that create and maintain this thin layer of cartilage that covers the surface of bones in joint regions are poorly understood, in part because tools to manipulate gene expression specifically in this tissue have not been available. Here we use regulatory information from the mouse Gdf5 gene (a bone morphogenetic protein [BMP] family member to develop new mouse lines that can be used to either activate or inactivate genes specifically in developing joints. Expression of Cre recombinase from Gdf5 bacterial artificial chromosome clones leads to specific activation or inactivation of floxed target genes in developing joints, including early joint interzones, adult articular cartilage, and the joint capsule. We have used this system to test the role of BMP receptor signaling in joint development. Mice with null mutations in Bmpr1a are known to die early in embryogenesis with multiple defects. However, combining a floxed Bmpr1a allele with the Gdf5-Cre driver bypasses this embryonic lethality, and leads to birth and postnatal development of mice missing the Bmpr1a gene in articular regions. Most joints in the body form normally in the absence of Bmpr1a receptor function. However, articular cartilage within the joints gradually wears away in receptor-deficient mice after birth in a process resembling human osteoarthritis. Gdf5-Cre mice provide a general system that can be used to test the role of genes in articular regions. BMP receptor signaling is required not only for early development and creation of multiple tissues, but also for ongoing maintenance of articular cartilage after birth. Genetic variation in the strength of BMP receptor signaling may be an important risk factor in human osteoarthritis, and treatments that mimic or augment BMP receptor signaling should be

  12. MORPHOMETRIC AND MORPHOLOGICAL STUDY OF ARTICULAR FACETS OF THE THORACOLUMBAR VERTEBRAL COLUMN IN NORTH INDIAN POPULATION

    Directory of Open Access Journals (Sweden)

    Rimpi Gupta

    2015-09-01

    Full Text Available Background: The articular processes of thoracolumbar vertebral column play an important role in weight transmission and determining the range and direction of movements between any two vertebrae. Size of these facets has been correlated with the magnitude of stress imposed on them. Purpose of study: The present study has been conducted on the articular processes of 510 vertebrae (thoracic: 360; lumbar:150 with the aim to provide high quality data sets for constructing the models of spine to study mechanics of spinal instrumentation. The length , width and the distance between the right & left superior & inferior articular processes have been measured with the vernier callipers. The presence/ absence of mamillary tubercle has been observed in the present study. Results: The length of thoracic SAFs was almost same at all levels whereas that of the lumbar SAFs increased gradually from L1-L5. However the width showed a variable trend. In case of thoracic IAFs both these parameters showed a variable trend. Whereas in lumbar region, these increased gradually from L1-L5. The distance between two inferior articular processes was more than that between two superior articular processes at almost all levels except T1-T3 & L1-L4 where reverse was true. The mamillary tubercle/process was altogether absent from T-1 to T-8. From T-9 to T-11, the number of vertebral column showing mamillary tubercle increased from 4-19. However at T-12, it was seen in 29 Vertebral columns. In lumbar region, it was well developed in all vertebrae and termed as mamillary process. Conclusion: The measurements obtained by present study reveals the importance of articular facets in understanding basic spinal mechanics and its application with respect to weight transmission.

  13. The rigid curette technique for the application of fibrin bioadhesive during hip arthroscopy for articular cartilage lesions.

    Science.gov (United States)

    Asopa, Vipin; Singh, Parminder J

    2014-04-01

    Encouraging midterm results have recently been reported for the arthroscopic treatment of delaminating articular cartilage lesions at the capsulolabral junction of the hip joint using fibrin bioadhesive. The needle used to introduce the bioadhesive is long, flexible, and often difficult to position. We describe a novel technique for introducing the needle that allows accurate placement behind the delaminated articular cartilage pocket during hip arthroscopy.

  14. Secondary knee instability caused by fracture of the stabilizing insert in a dual-articular total knee

    DEFF Research Database (Denmark)

    Boesen, Morten P; Jensen, Tim Toftgaard; Husted, Henrik

    2004-01-01

    A case of a fractured polyethylene stabilizing insert causing secondary knee instability in a Dual-articular total knee arthroplasty (TKA) is presented. A 65-year-old woman who underwent surgery with a Dual-articular TKA 4 years earlier had a well-functioning prosthesis until a fall, after which ...

  15. Mapping the Articular Contact Area of the Long Head of the Biceps Tendon on the Humeral Head

    Directory of Open Access Journals (Sweden)

    Brent J. Morris

    2014-01-01

    Full Text Available The purpose of this investigation was to calculate the contact surface area of the long head of the biceps (LHB in neutral position and abduction. We sought to determine whether the LHB articulates with the humeral head in a consistent pattern comparing articular contact area in neutral position and abduction. Eleven fresh frozen matched cadaveric shoulders were analyzed. The path of the biceps tendon on the articular surface of the humeral head and the total articular surface were digitized using a MicronTracker 2 H3-60 three-dimensional optical tracker. Contact surface area was significantly less in abduction than in neutral position (P=0.002 with a median ratio of 41% (36%, 47.5%. Ratios of contact area in neutral position to full articular surface area were consistent between left and right shoulders (rho=1, P=0.017 as were ratios of abduction area to full articular surface area (rho= 0.97, P=0.005. The articular contact surface area is significantly greater in neutral position than abduction. The ratios of articular contact surface areas to total humeral articular surface areas have a narrow range and are consistent between left and right shoulders of the same cadaver.

  16. The influence of surface porosity on gap-healing around intra-articular implants in the presence of migrating particles

    DEFF Research Database (Denmark)

    Rahbek, Ole; Kold, Soren; Zippor, Berit;

    2005-01-01

    -pore coating (Fi) were inserted intra-articular in exact fit or with a 0.75 mm peri-implant gap. A weight-loaded implant device in the distal femur was used. We used a randomized paired design in eight dogs. PE particles were injected repeatedly intra-articular in the knee until the dogs were killed after 8...

  17. Rigidez articular - doi: 10.5102/ucs.v3i1.550

    OpenAIRE

    Gustavo Rocha Velloso

    2008-01-01

    As causas da rigidez articulatória devem ser bem avaliadas quando presentes na história clínica dos pacientes. Fatores intrínsecos e extrínsecos devem ser considerados com cuidado. A qualidade da superfície articulatória, o nivelamento da cartilagem e a fibrose são causas comuns da queixa de rigidez articular. O aumento do líquido sinovial e a hipertrofia sinovial podem ser fatores importantes na restrição do movimento articular.

  18. Rigidez articular - doi: 10.5102/ucs.v3i1.550

    Directory of Open Access Journals (Sweden)

    Gustavo Rocha Velloso

    2008-04-01

    Full Text Available As causas da rigidez articulatória devem ser bem avaliadas quando presentes na história clínica dos pacientes. Fatores intrínsecos e extrínsecos devem ser considerados com cuidado. A qualidade da superfície articulatória, o nivelamento da cartilagem e a fibrose são causas comuns da queixa de rigidez articular. O aumento do líquido sinovial e a hipertrofia sinovial podem ser fatores importantes na restrição do movimento articular.

  19. Interrelationship between mandibular congealer head position in trasncranial view and articular disc position

    Energy Technology Data Exchange (ETDEWEB)

    Ko, Jae Hee; Choi, Soon Chul; You, Dong Soo [Dept. of Oral and Maxillofacial Radiology, Graduate School, Seoul National University, Seoul (Korea, Republic of)

    1995-08-15

    This study was designed to evaluate the interrelationship between the congealer head position in transcranial view and the articular disc position in the arthrography. The condylar positions were assessed by subjective method and linear measurement method on the transcranial view. The subjects for this study consisted of 24 symptomatic joints with normal disc position, 37 joints with anterior disc displacement with reduction and 44 joints with anterior disc displacement without reduction that were classified by arthrotomography under the fluoroscopic guidance. The interrelationship between the condylar head position in transcranial view and the articualr disc position in the arthrography was evaluated by Chi square test. The following results were obtained: 1. There was no significant interrelationship between the position of congealer head in closed mouth state on transcranial view and articular disc position in the arthrography (p>0.05). 2. There was no significant interrelationship between the changes of interarticular distance in 1 inch opening state and articular disc position in the arthrography (p>0.05). 3. There was no significant interrelationship between the position of condylar head related to the apex of articular eminence in 1 inch opening state and articular disc position in the arthrography (p>0.05). 4. There was significant interrelationship between the changes of interarticular distance that is assessed by linear measurement method in maximum opening state and articular disc position in the arthrography (p<0.05), but there was no significant interrelationship when the condylar head position was assessed by subjective method (p>0.05). 5. There was significant interrelationship between the degree of condylar translation in maximum opening state and articular disc position in the arthrography (p<0.01). 6. The correlation coefficient between two methods to assess the position of condylar head were 0.7989: the condylar head position in articular fossa

  20. A Case of Recurrent Acute Pancreatitis Due to Intra-Articular Corticosteroid Injection

    Directory of Open Access Journals (Sweden)

    Patompong Ungprasert

    2014-03-01

    Full Text Available Context Corticosteroid is a well-established cause of drug-induced pancreatitis. However, acute pancreatitis from intraarticularinjection of corticosteroid has never been described. Case report A 69-year-old male presented with acuteabdominal pain and was diagnosed with acute pancreatitis. The patient had one episode of acute pancreatitis two yearearlier. Both episodes occurred after intra-articular cortisone injection. Investigations for other causes of pancreatitis werenegative. Conclusion We report the first case of acute pancreatitis from intra-articular corticosteroid injection. Physiciansshould be aware of this adverse reaction of corticosteroid that can even occur with local administration.

  1. COOPER (COupled OPEration Robot): control de una estructura articular RRR acoplada a un manipulador

    OpenAIRE

    Perea Fuentes, Iván; García Gómez, Gabriel Jesús; Jara Bravo, Carlos Alberto; Pomares Baeza, Jorge; Candelas Herías, Francisco Andrés; Torres Medina, Fernando

    2011-01-01

    Pendiente de publicación en las actas de las XXXII Jornadas de Automática, Sevilla, 7-9 septiembre 2011. Este artículo presenta el modelado, construcción y control de un robot articular tipo RRR, especialmente diseñado para ser acoplado al extremo de un robot antropomórfico PA-10 de Mitsubishi. A este robot articular de tres grados de libertad se le ha asignado como nombre el acrónimo COOPER (COupled OPEration Robot), y su principal finalidad es dotar al PA-10 de la capacidad de visualizac...

  2. Tratamiento con electrocauterización de las lesiones premalignas del cérvix

    Directory of Open Access Journals (Sweden)

    Israel Meza G

    2014-11-01

    Full Text Available Se presentaron los resultados del tratamiento con electrocauterización de las neoplasias intraepiteliales del cérvix en 430 pacientes atendidas en el Hospital Universitario del Valle, en el Hospital San Juan de Dios y en el Centro Hospital Cañaveralejo en Cali, Colombia, entre 1982 y 1992. Inicialmente se seleccionaron 455 mujeres que consultaron con citologías anormales (inclusive Papanicolau II con cambios coilocíticos y atipias inflamatorias. Para el análisis final sólo se incluyeron 430 pacientes. A todas se les practicó colposcopia y biopsia dirigida y se confirmaba el diagnóstico de neoplasia intraepitelial del cérvix. Se hizo seguimiento con citología y colposcopia. Se obtuvo una respuesta global de 90.1% al primer tratamiento, respuesta que aumenta a 96.8% cuando se incluyeron las pacientes que respondieron a un segundo tratamiento. Se discuten las ventajas y desventajas del método con respeto a otros métodos existentes.

  3. Analgesic effects of intra-articular botulinum toxin Type B in a murine model of chronic degenerative knee arthritis pain

    Directory of Open Access Journals (Sweden)

    Stephanie Anderson

    2010-09-01

    Full Text Available Stephanie Anderson1,2, Hollis Krug1,2, Christopher Dorman1, Pari McGarraugh1, Sandra Frizelle1, Maren Mahowald1,21Rheumatology Section, Veteran’s Affairs Medical Center, Minneapolis, Minnesota; 2Division of Rheumatology and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, Minnesota, USAObjective: To evaluate the analgesic effectiveness of intra-articular botulinum toxin Type B (BoNT/B in a murine model of chronic degenerative arthritis pain.Methods and materials: Chronic arthritis was produced in adult C57Bl6 mice by intra-articular injection of Type IV collagenase into the left knee. Following induction of arthritis, the treatment group received intra-articular BoNT/B. Arthritic control groups were treated with intra-articular normal saline or sham injections. Pain behavior testing was performed prior to arthritis, after induction of arthritis, and following treatments. Pain behavior measures included analysis of gait impairment (spontaneous pain behavior and joint tenderness evaluation (evoked pain response. Strength was measured as ability to grasp and cling.Results: Visual gait analysis showed significant impairment of gait in arthritic mice that improved 43% after intra-articular BoNT/B, demonstrating a substantial articular analgesic effect. Joint tenderness, measured with evoked pain response scores, increased with arthritis induction and decreased 49.5% after intra-articular BoNT/B treatment. No improvement in visual gait scores or decrease in evoked pain response scores were found in the control groups receiving intra-articular normal saline or sham injections. Intra-articular BoNT/B was safe, and no systemic effects or limb weakness was noted.Conclusions: This study is the first report of intra-articular BoNT/B for analgesia in a murine model of arthritis pain. The results of this study validate prior work using intra-articular neurotoxins in murine models. Our findings show chronic degenerative arthritis

  4. Infección Activa por el Citomegalovirus (CMV) en el trasplante alogénico de precursores hematopoyéticos:Investigación de nuevos factores biológicos para la estimación del riesgo y análisis integral de los mecanismos inmunitarios que la previenen y controlan

    OpenAIRE

    Giménez Quiles, Estela Berenice

    2016-01-01

    Citomegalovirus (CMV) es causa frecuente de morbididad y mortalidad en el marco del trasplante alogénico de precursores hematopoyéticos (alo-TPH). CMV puede ocasionar enfermedad orgánica o tisular (neumonía intersticial o enfermedad gastrointestinal, con mayor frecuencia), en virtud de su “citopatogenicidad” . CMV también puede causar morbididad a través de mecanismos indirectos, relacionados con su capacidad inmunosupresora y pro-inflamatoria; en ese contexto, CMV parece incrementar el ries...

  5. Problemas de Sociología del Deporte

    OpenAIRE

    2011-01-01

    El presente artículo es una apuesta por reconstruir, articular y problematizar los aportes y los avances de investigación en torno a los estudios sociales del deporte y el tiempo libre, puestos en discusiones en el marco de la mesa de trabajo sobre problemáticas de la sociología del deporte, llevada a cabo durante el 9no Congreso Argentino y 4to Latinoamericano de Educación Física y Ciencias. La lectura holística e integral de las diferentes producciones académicas, y los diálogos que de ella...

  6. Historia del mundo contemporáneo (1870-2008)

    OpenAIRE

    Béjar Puche, María Dolores

    2015-01-01

    Este libro es el producto del esfuerzo y el compromiso de un grupo de docentes de la Facultad de Humanidades y Ciencias de la Educación de la UNLP que desde hace mucho tiempo viene apostando a la elaboración de materiales especialmente pensados para los estudiantes universitarios y basados en la firme voluntad de articular los resultados de la investigación con las necesidades y objetivos de la enseñanza en un campo de enorme complejidad como es el de la historia del siglo XX. En efecto, los ...

  7. Asociación entre porphyromona gingivalis y proteína C reactiva en enfermedades sistémicas inflamatorias Association between porphyromonas gingivalis and C-reactive protein in systemic inflammatory diseases

    Directory of Open Access Journals (Sweden)

    C.M. Ardila Medina

    2010-04-01

    Full Text Available La proteína C reactiva (PCR es un marcador serológico de la inflamación asociado con incremento en el riesgo de enfermedades sistémicas inflamatorias (ESI. La periodontitis también se relaciona con niveles elevados de PCR en adultos y con una reducción de la misma después de su tratamiento. Así, se ha postulado que la PCR puede ser un posible mediador de la asociación entre periodontitis y ESI. Los patógenos periodontales además de inducir inflamación local y destrucción tisular están involucrados en el aumento de la respuesta sistémica inflamatoria e inmunológica. Diferentes autores han investigado la relación entre los anticuerpos para algunos patógenos periodontales y la PCR, pero la asociación se ha notificado firmemente para IgG a Porphyromona gingivalis. Es escasa la evidencia de asociación de una medida directa entre patógenos periodontales y PCR, sin embargo es muy importante debido a que la presencia de anticuerpos no necesariamente es un indicador de infección activa.C-reactive protein (CRP is a serological marker of systemic inflammation that has been associated with increased risk systemic inflammatory diseases. Periodontitis has also been linked to elevated CRP levels in adults as well as with a reduction in PCR after its treatment. It is thus postulated that CRP might be a possible mediator of the association between periodontitis and systemic inflammatory diseases. Periodontal pathogens do not induce only local inflammation and tissue destruction. They are also involved in systemic increases in inflammatory and inmmune responses. Several studies have investigated antibodies to various periodontal pathogens in relation to CRP, but the association has been reported consistently only for IgG to Porphyromonas gingivalis. Evidence is sparse on the association between a direct measure of periodontal pathogens and CRP, while it is more important because the presence of antibody titers is not necessarily indicative

  8. Efectividad a corto plazo del vendaje neuromuscular y vendaje funcional en la corrección del retropié pronado y supinado

    OpenAIRE

    Luque Suárez, Alejandro

    2011-01-01

    La utilización de métodos de corrección articular de las dealineaciones del pie en el plano frontal dentro del campo de la medicina, fisioterapia o la podología se encuentra ampliamente documentado y ha sido comúnmente empleado. Dentro de estos dispositivos se encuentran el vendaje funcional y el vendaje neuromuscular (también denominado kinesiotaping, medical taping, neurotaping o balance taping). Objetivos: 1.Comparar la efectividad del vendaje funcional y el vendaje neuromuscular en la...

  9. Inestabilidad compleja del codo

    Directory of Open Access Journals (Sweden)

    Héctor Gabriel Díaz Carrillo

    2014-08-01

    Full Text Available La inestabilidad compleja del codo es de reciente descripción y controversial en sus resultados; es el estado que se deriva del daño estructural y funcional, producido por la incongruencia de las superficies articulares y las estructuras ligamentosas que estabilizan el codo. Se realizó un estudio descriptivo prospectivo, en el período comprendido entre enero de 2011 y abril de 2013, en una muestra no probabilística de ocho pacientes (diez codos, seleccionados según criterios de inclusión y exclusión. Los objetivos fundamentales del estudio fueron: la actualización de conocimientos para el manejo de la enfermedad y la caracterización de los resultados obtenidos en los afectados por esta dolencia que fueron operados en el Hospital Dr. Ernesto Guevara de la Serna de la provincia de Las Tunas. Se analizaron los datos mediante técnicas estadísticas descriptivas y se realizó la evaluación clínica y radiográfica de los lesionados. El tratamiento se ejecutó según los hallazgos y consistió en: reparación ligamentosa, actuación sobre las partes óseas dañadas y colocación de osteosíntesis diversas. La edad promedio fue de 39,2 años y predominó el sexo masculino. A todos se les practicó reparación ligamentosa, siete cupulectomías y seis aplicaciones de cerclajes anti-distractores. Existieron dos reluxaciones y una sepsis local. La amplitud de movimientos fue aceptable dentro del rango compatible, con una buena función ergonómica; de acuerdo a las comparaciones bibliográficas actualizadas que se realizaron. La fijación y reparación de los estabilizadores del codo brindan buenos resultados funcionales. La sistematización en el manejo de la enfermedad, la detección de complicaciones y el arsenal terapéutico disponible son factores a tener en cuenta

  10. Presence and mechanism of knee articular cartilage degeneration after meniscal reconstruction in dogs

    NARCIS (Netherlands)

    van Tienen, TG; Heijkants, RGJC; de Groot, JH; Pennings, AJ; Poole, AR; Veth, RPH; Buma, P

    2003-01-01

    Objective: Partial meniscectomy is the golden standard for treating a bucket-handle tear in the meniscus of the knee, but it inevitably leads to articular cartilage degeneration. Surgical creation of an access channel between the lesion and the vascularized synovial lining is intended to induce ingr

  11. Porous polymers for repair and replacement of the knee joint meniscus and articular cartilage

    NARCIS (Netherlands)

    Klompmaker, Jan

    1992-01-01

    The studies presented here were initiated to answer a variety of questions concerning firstly the repair and replacement of the knee joint meniscus and, secondly, the repair of full-thickness defects of articular cartilage. AIMS OF THE STUDIES I To assess the effect of implantation of a porous polym

  12. Presence and mechanism of knee articular cartilage degeneration after meniscal reconstruction in dogs.

    NARCIS (Netherlands)

    Tienen, Tony van; Heijkants, R.G.J.C.; Groot, J.H. de; Pennings, A.J.; Poole, A.R.; Veth, R.P.H.; Buma, P.

    2003-01-01

    OBJECTIVE: Partial meniscectomy is the golden standard for treating a bucket-handle tear in the meniscus of the knee, but it inevitably leads to articular cartilage degeneration. Surgical creation of an access channel between the lesion and the vascularized synovial lining is intended to induce ingr

  13. Chondrogenic differentiation of human articular chondrocytes differs in biodegradable PGA/PLA scaffolds

    DEFF Research Database (Denmark)

    Zwingmann, Joern; Mehlhorn, Alexander T; Südkamp, Norbert

    2007-01-01

    Cartilage tissue engineering is applied clinically to cover and regenerate articular cartilage defects. Two bioresorbable nonwoven scaffolds, polyglycolic acid (PGA) and poly(lactic-co-glycolic acid) (PLGA) (90/10 copolymer of L-lactide and glycolide), were seeded with human chondrocytes after in...

  14. Glucosamine:chondroitin or ginger root extract have little effect on articular cartilage in swine

    Science.gov (United States)

    Sows are culled at a high rate from breeding herds due to musclo-skeletal problems and lameness. Research in our laboratory has shown that even first-parity sows have significant amounts of osteochondritic lesions of their articular cartilage. Glusoamine chondroitin and ginger root extract have both...

  15. Intra-Articular Analgesia and Steroid Reduce Pain Sensitivity in Knee OA Patients

    DEFF Research Database (Denmark)

    Jørgensen, Tanja Schjødt; Graven-Nielsen, Thomas; Ellegaard, Karen;

    2014-01-01

    before, immediately after, and two weeks after ultrasound guided intra-articular injection of lidocaine combined with glucocorticosteroid. Computer-controlled and manual pressure algometers were used to assess PPT on the knee, vastus lateralis, tibialis anterior, and the extensor carpi radialis longus...

  16. Preliminary investigation of intrinsic UV fluorescence spectroscopic changes associated with proteolytic digestion of bovine articular cartilage

    Science.gov (United States)

    Lewis, William; Padilla-Martinez, Juan-Pablo; Ortega-Martinez, Antonio; Franco, Walfre

    2016-03-01

    Degradation and destruction of articular cartilage is the etiology of osteoarthritis (OA), an entity second only to cardiovascular disease as a cause of disability in the United States. Joint mechanics and cartilage biochemistry are believed to play a role in OA; an optical tool to detect structural and chemical changes in articular cartilage might offer benefit for its early detection and treatment. The objective of the present study was to identify the spectral changes in intrinsic ultraviolet (UV) fluorescence of cartilage that occur after proteolytic digestion of cartilage. Bovine articular cartilage samples were incubated in varying concentrations of collagenase ranging from 10ug/mL up to 5mg/mL for 18 hours at 37°C, a model of OA. Pre- and post-incubation measurements were taken of the UV excitation-emission spectrum of each cartilage sample. Mechanical tests were performed to determine the pre- and post-digestion force/displacement ratio associated with indentation of each sample. Spectral changes in intrinsic cartilage fluorescence and stiffness of the cartilage were associated with proteolytic digestion. In particular, changes in the relative intensity of fluorescence peaks associated with pentosidine crosslinks (330 nm excitation, 390 nm emission) and tryptophan (290 nm excitation, 340 nm emission) were found to correlate with different degrees of cartilage digestion and cartilage stiffness. In principle, it may be possible to use UV fluorescence spectral data for early detection of damage to articular cartilage, and as a surrogate measure for cartilage stiffness.

  17. THE EFFECT IN-VITRO OF IRRIGATING SOLUTIONS ON INTACT RAT ARTICULAR-CARTILAGE

    NARCIS (Netherlands)

    Bulstra, Sjoerd K; KUIJER, R; EERDMANS, P; VANDERLINDEN, AJ

    1994-01-01

    Rat patellae were preincubated with culture medium M199 for one hour and then with either fresh culture medium or Ringer's solution, Ringer lactate, Ringer glucose, normal saline or Betadine for another hour. The rate of proteoglycan synthesis in the articular cartilage was then measured by uptake o

  18. Intra-Articular Lubricin Gene Therapy for Post-Traumatic Arthritis

    Science.gov (United States)

    2015-09-01

    develop a survival animal model of intra-articular fracture (IAF) in which all major pathophysiological attributes of corresponding human clinical...Y, Gandhi V, Prasad M, Yu W, Wang X, Zhu Q, et al. Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar

  19. Evaluation of influence of proteoglycans on hydration of articular cartilage with the use of ultrasound

    Directory of Open Access Journals (Sweden)

    Yi-yi YANG

    2015-04-01

    Full Text Available Objective To monitor the changes in hydration behaviour of articular cartilage induced by degradation of proteoglycans, and to explore the effect of proteoglycans on hydration behaviour of articular cartilage by using high-frequency ultrasound. Methods Twelve porcine patellae with smooth cartilage surface were prepared and equally divided into two groups: normal group without any enzyme treatment, and trypsin group they were treated with 0.25% trypsin for 8h to digest proteoglycan in the cartilage. The hydration behaviour of the cartilage tissue was scanned by high-frequency ultrasound system with a central frequency of 25MHz. Parameters including cartilage hydration strain and cartilage thickness were measured. The histopathological changes in the articular cartilage were observed under a light microscope. Results It took approximately 20min to reach equilibrium during the hydration process in the normal cartilages, while proteoglycan-degraded cartilage took only about 5min to achieve equilibrium. The equilibrium strain of normal cartilage was 3.5%±0.5%. The degradation of proteoglycans induced a significant decrease in equilibrium strain (1.8%±0.2%, P0.05. Conclusion Proteoglycans play an important role in hydration behaviour of articular cartilage. The degradation of proteoglycans could induce degeneration of cartilage structure and decrease in hydration behaviour after dehydration. DOI: 10.11855/j.issn.0577-7402.2015.03.03

  20. Differences in articular-eminence inclination between medieval and contemporary human populations.

    Science.gov (United States)

    Kranjčić, Josip; Vojvodić, Denis; Žabarović, Domagoj; Vodanović, Marin; Komar, Daniel; Mehulić, Ketij

    2012-08-01

    The articular-eminence inclination is an important element in the biomechanics of the temporomandibular joint and the entire masticatory system; however, very little is known about this inclination in archaeological human populations. Therefore, the aim of this study was to determine the values of, in addition to the differences between, the articular-eminence inclination in medieval and contemporary human populations. The study was carried out on two dry skull groups. The first group consisted of 14 dry skulls from the medieval culture group Bijelo Brdo (BB) of East Croatia, and the other consisted of 137 recent dry skulls from the osteologic collection of the Institute of Anatomy (IA) in Zagreb. All BB skulls were dentulous, whereas the IA skulls were divided into dentulous and edentulous groups. The articular-eminence inclination was measured in relation to the Frankfurt horizontal plane on digital images of the skull's two lateral views using AutoCAD computer software. The mean value of the articular-eminence inclination in the BB sample group (49.57°) was lower, with a statistical significance (pmedieval specimens are needed to confirm the results obtained from this study.

  1. Increasing lateral tibial slope: is there an association with articular cartilage changes in the knee?

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Nasir; Shepel, Michael; Leswick, David A.; Obaid, Haron [University of Saskatchewan, Department of Medical Imaging, Royal University Hospital, and College of Medicine, Saskatoon, Saskatchewan (Canada)

    2014-04-15

    The geometry of the lateral tibial slope (LTS) plays an important role in the overall biomechanics of the knee. Through this study, we aim to assess the impact of LTS on cartilage degeneration in the knee. A retrospective analysis of 93 knee MRI scans (1.5 T or 3 T) for patients aged 20-45 years with no history of trauma or knee surgery, and absence of internal derangement. The LTS was calculated using the circle method. Chondropathy was graded from 0 (normal) to 3 (severe). Linear regression analysis was used for statistical analysis (p < 0.05). In our cohort of patients, a statistically significant association was seen between increasing LTS and worsening cartilage degenerative changes in the medial patellar articular surface and the lateral tibial articular surface (p < 0.05). There was no statistically significant association between increasing LTS and worsening chondropathy of the lateral patellar, medial trochlea, lateral trochlea, medial femoral, lateral femoral, and medial tibial articular surfaces. Our results show a statistically significant association between increasing LTS and worsening cartilage degenerative changes in the medial patella and the lateral tibial plateau. We speculate that increased LTS may result in increased femoral glide over the lateral tibial plateau with subsequent increased external rotation of the femur predisposing to patellofemoral articular changes. Future arthroscopic studies are needed to further confirm our findings. (orig.)

  2. Is magnetic resonance imaging reliable in predicting clinical outcome after articular cartilage repair of the knee?

    NARCIS (Netherlands)

    Windt, de T.S.; Welsch, G.H.; Brittberg, M.; Vonk, L.A.; Marlovits, S.; Trattnig, S.; Saris, D.B.F.

    2013-01-01

    Background: While MRI can provide a detailed morphological evaluation after articular cartilage repair, its additional value in determining clinical outcome has yet to be determined. Purpose: To evaluate the correlation between MRI and clinical outcome after cartilage repair and to identify parame

  3. Articular Cartilage Thickness Measured with US is Not as Easy as It Appears

    DEFF Research Database (Denmark)

    Torp-Pedersen, Søren; Bartels, E. M.; Wilhjelm, Jens E.;

    2011-01-01

    Background: Theoretically, the high spatial resolution of US makes it well suited to monitor the decrease in articular cartilage thickness in osteoarthritis. A requirement is, however, that the borders of the cartilage are correctly identified and that the cartilage ismeasured under orthogonal in...

  4. Articular cartilage thickness measured with US is not as easy as it appears

    DEFF Research Database (Denmark)

    Torp-Pedersen, S; Bartels, E M; Wilhjelm, Jens E.;

    2011-01-01

    Theoretically, the high spatial resolution of US makes it well suited to monitor the decrease in articular cartilage thickness in osteoarthritis. A requirement is, however, that the borders of the cartilage are correctly identified and that the cartilage is measured under orthogonal insonation. I...

  5. THE FUNCTIONAL EFFECTIVENESS OF A CELL-ENGINEERED CONSTRUCT FOR THE REGENERATION OF ARTICULAR CARTILAGE

    Directory of Open Access Journals (Sweden)

    V. I. Sevastianov

    2015-01-01

    Full Text Available The aim of this study is an analysis of the functional effectiveness of a biomedical cell product consisting of a biopolymer microheterogeneous collagen-containing hydrogel (BMCH, human adipose-derived mesenchymal stromal cells (hADMSCs, and chondrogenic induction medium in the regeneration of articular cartilage. Materials and methods. The test model of the adjuvant arthritis was used (female Soviet Chinchilla rabbits with the further development into osteoarthrosis (OA combined with the clinical, biochemical, radiological, and histochemical trials. Results. On Day 92 of the OA model it has been found that the intra-articular introduction of a BMCH with hADMSCs into the left knee joint (n = 3 30 days after the OA modeling, as opposed to the right joint (negative control, n = 3, stimulates the regenerative processes of the cartilaginous tissue structure characterized by the formation of chondrocyte «columns», the emergence of isogenic groups in the intracellular matrix and the regeneration of its structure. Upon the intra-articular introduction of a BMCH (n = 3 such effects are markedly less pronounced. Conclusions. A significant regenerative potential of a cell-engineered construct of human articular tissue (CEC ATh has been proven. It is possible to presume that biostimulating properties of CEC ATh are due to the activating effect of a biomedical cell product on the stem cell migration processes from the surrounding tissue into the injured area with their subsequent differentiation. 

  6. Topographical mapping of biochemical properties of articular cartilage in the equine fetlock joint

    NARCIS (Netherlands)

    Brama, P.A.J.; Tekoppele, J.M.; Bank, R.A.; Karssenberg, D.; Barneveld, A.; Weeren, P.R. van

    2000-01-01

    The aim of this study was to evaluate topographical differences in the biochemical composition of the extracellular matrix of articular cartilage of the normal equine fetlock joint. Water content, DNA content, glycosaminoglycan (GAG) content and a number of characteristics of the collagen network (t

  7. Intra-articular injection of tenoxicam in osteoarthritic knee joints with effusion.

    Science.gov (United States)

    Oztuna, Volkan; Eskandari, Metin; Bugdayci, Resul; Kuyurtar, Fehmi

    2007-12-01

    Thirty patients who had grade II to III osteoarthritis according to Kellgren-Lawrence system and presenting with acute effusion of the knee joint were randomly assigned to 2 groups. All patients were treated with aspiration of the synovial fluid, cold application, and rest. Fifteen patients received an intra-articular injection of tenoxicam 20 mg following aspiration. The other group was administered oral tenoxicam 20 mg a day for 10 days. Patients were examined at 2, 4, and 8 weeks and then in 3-month intervals. At followup visits, pain was assessed using visual analog scale: range of motion, and effusion of the knee joint were recorded. A repeated measure test was used to determine the significance of changes in pain and mobility between the groups. Student's Neyman Keuls test was used to determine the significance of differences within the groups. Chi-square test was used for the number of episodes. The intra-articular injection group had more rapid pain relief than the oral treatment group (P < .01). At the end of 1 year, the number of effusions was significantly lower in the intra-articular treatment group (P < .01). These results indicate that intra-articular injection of tenoxicam provides rapid pain relief in the patients with acute flare-up of knee osteoarthritis and helps to prevent effusion.

  8. Chondrogenic potential of articular chondrocytes depends on their original location in the knee

    NARCIS (Netherlands)

    Bekkers, J.E.J.; Saris, D.B.F.; Tsuchida, A.I.; Rijen, van M.H.P.; Dhert, W.J.A.; Creemers, L.

    2014-01-01

    Objective: This study aimed to investigate the regenerative capacity of chondrocytes derived from debrided defect cartilage and healthy cartilage from different regions in the joint in order to determine the best cell source for regenerative cartilage therapies. Methods: Articular cartilage was obta

  9. Adverse effects of extra-articular corticosteroid injections: A systematic review

    NARCIS (Netherlands)

    A. Brinks (Tineke); B.W. Koes (Bart); A.C. Volkers (Aloysius); J.A.N. Verhaar (Jan); S.M. Bierma-Zeinstra (Sita)

    2010-01-01

    textabstractBackground. To estimate the occurrence and type of adverse effects after application of an extra-articular (soft tissue) corticosteroid injection. Methods. A systematic review of the literature was made based on a PubMed and Embase search covering the period 1956 to January 2010. Case re

  10. Age-related accumulation of Maillard reaction products in human articular cartilage collagen

    NARCIS (Netherlands)

    Verzijl, N.; Groot, J. de; Oldehinkel, E.; Bank, R.A.; Thorpe, S.R.; Baynes, J.W.; Bayliss, M.T.; Bijlsma, J.W.J.; Lafeber, F.P.J.G.; TeKoppele, J.M.

    2000-01-01

    Non-enzymic modification of tissue proteins by reducing sugars, the so-called Maillard reaction, is a prominent feature of aging. In articular cartilage, relatively high levels of the advanced glycation end product (AGE) pentosidine accumulate with age. Higher pentosidine levels have been associated

  11. Accuracy of ultrasound-guided injections of thoracolumbar articular process joints in horses

    DEFF Research Database (Denmark)

    Fuglbjerg, Vibeke; Nielsen, J.V.; Thomsen, Preben Dybdahl

    2010-01-01

    in the literature. Objectives: To evaluate factors of affecting the accuracy of intra-articular injections of the APJs in the caudal thoracolumbar region. Method: One-hundred-and-fifty-four injections with blue dye were performed on APJs including the T14-L6 region in 12 horses subjected to euthanasia for reasons...

  12. Is nephrolithiasis an unrecognized extra-articular manifestation in ankylosing spondylitis?

    DEFF Research Database (Denmark)

    Jakobsen, Ane Krag; Jacobsson, Lennart T H; Patschan, Oliver;

    2014-01-01

    BACKGROUND: Ankylosing spondylitis (AS) is associated with several extra-articular manifestations. Nephrolithiasis (NL) has not been recognized as one of those, however, several factors known to increase the risk of NL are at play in AS patients. The objective was to estimate rates and predictors...

  13. Displaced Intra-articular Fractures of the Calcaneus: with an emphasis on minimally invasive surgery

    NARCIS (Netherlands)

    T. Schepers (Tim)

    2009-01-01

    textabstractDisplaced intra-articular calcaneal fractures are complex injuries. Classically these fractures are treated with open reduction and internal fixation (ORIF) or conservatively. When comparing these two treatment modalities, ORIF has a significantly higher rate of wound complications and c

  14. Acute and chronic response of articular cartilage to Ho:YAG laser irradiation

    Science.gov (United States)

    Trauner, Kenneth B.; Nishioka, Norman S.; Flotte, Thomas J.; Patel, Dinesh K.

    1992-06-01

    A Ho:YAG laser system operating at a wavelength of 2.1 microns has recently been introduced for use in arthroscopic surgery. The acceptability of this new tool will be determined not only by its ability to resect tissue, but also by its long term effects on articular surfaces. In order to investigate these issues further, we performed two studies to evaluate the acute and chronic effects of the laser on cartilaginous tissue. We evaluated the acute, in vitro effects of 2.1 micron laser irradiation on articular and fibrocartilage. This included the measurement of ablation efficiency, ablation threshold and thermal damage in both meniscus and articular cartilage. To document the chronic effects on articular cartilage in vivo, we next performed a ten week healing study. Eight sheep weighing 30 - 40 kg underwent bilateral arthrotomy procedures. Multiple full thickness and partial thickness defects were created. Animals were sacrificed at 0, 2, 4, and 10 weeks. The healing study demonstrated: (1) no healing of full or partial thickness defects at 10 weeks with hyaline cartilage; (2) fibrocartilaginous granulation tissue filling full thickness defects at two and four weeks, but no longer evident at ten weeks; (3) chondrocyte necrosis extending to greater than 900 microns distal to ablation craters at four weeks with no evidence of repair at later dates; and (4) chondrocyte hyperplasia at the borders of the damage zone at two weeks but no longer evident at later sacrifice dates.

  15. [Indirect articular lymphography using Tc 99m-labeled Dextran in animals].

    Science.gov (United States)

    Albuquerque, M; Pedroso de Lima, J; Cardoso, A; Mendes, F; Pires, J; Canha, N; Branco, R

    1990-01-01

    Looking for a standardization of the articular lymphoscintigraphy, an experimental research was conducted on 14 dogs injected in the ankle, with 2.5 mCi of 99m Tc-labeled dextran (P.M. = 70,000). Good scintigraphic images of the lymphatic system have been obtained. After having collected blood samples during the experimentation as well as aliquots of organs and of tissues, after the necropsy of the animal, it was verified that the 99m Tc-labeled dextran was useful for quantitative studies of the articular lymphatic drainage. The activities attained, in the drainage lymph nodes of injected articulation, are 152 times superior to those obtained in the kidney and one gramma of popliteal ganglion was 8929 times more active than one gramma of blood. The dextran 70,000, widely used in our clinical routine, can be injected to the human being, without any risk, and it may be the tracer which permits studies of the articular lymphatic drainage and the usage of the lymphoscintigraphy, already in expansion in many other Medicine branches, in the articular studies, nowadays.

  16. Anatomía funcional del cuerpo estriado y la corteza cerebral: su relación con el movimiento

    OpenAIRE

    Buffone, Gabriel Darío; Dalto, Carlos

    2013-01-01

    El objetivo de la siguiente ponencia es revalorizar y reconocer aquellos aspectos anatómicos y funcionales de algunos elementos del sistema nervioso imprescindibles para el correcto funcionamiento del cuerpo humano, tanto en los movimientos deportivos, como en la variedad infinita de los actos motores resumidos en las contracciones musculares. Ante los diferentes rangos articulares posibles y las determinadas acciones musculares específicas, la corteza cerebral y el cuerpo estriado partici...

  17. EFECTO DE LA ROSIGLITAZONA SOBRE LA RESPUESTA CELULAR INFLAMATORIA EN LA CICATRIZACIÓN DE PACIENTES CON DIABETES MELLITUS TIPO 2.

    OpenAIRE

    Villaseñor Figueroa, Omar Abraham

    2012-01-01

    INTRODUCCIÓN: La Diabetes Mellitus tipo 2 (DM2), está condicionada por múltiples mecanismos fisiopatológicos, asociada a factores ambientales y genéticos, provocando resistencia a la insulina y disfunción de la célula β del páncreas; la cicatrización se encuentra alterada por presentar un estado inflamatorio persistente, produciendo señales químicas alteradas y disfunción celular para reparar los tejidos. OBJETIVO: Evaluar el efecto de la Rosiglitazona sobre la respuesta cel...

  18. Patogénesis de la enfermedad pélvica inflamatoria. Modelo animal con la biovariedad murina de Chlamydia trachomatis

    Directory of Open Access Journals (Sweden)

    Fabio Carmona Velásquez

    2009-10-01

    Full Text Available Se inocularon hembras de ratones blancos suizo (Balb/c, entre 4 y 6 semanas con la serovariedad MoPn de Chlamydia trachomatis para producirles una salpingitis clamidial experimental. Directamente en la rama uterina izquierda se inyectaron 30 µl equivalente a 6 x 104 UFI. La misma cantidad se inyectó en la bursa del ovario del mismo lado, a través del tejido graso que se encuentra en este sitio. Se sacrificaron grupos de hembras a los 7 y 14 días después de la inoculación para buscar inflamación, hidrosálpinx y respuesta de anticuerpos tipo IgG e IgM. Otras hembras inoculadas se aparearon para observar la tasa de infertilidad bilateral que ocasionaba la infección. Un tercer grupo de animales se trató con tetraciclina, ibuprofén y prostaglandina E1. El tratamiento temprano, hacia el segundo día después de la inoculación, impidió la inflamación, la formación de hidrosálpinx y la infertilidad normal bilateral. Los agentes antiinflamatorios, usados solos, no tuvieron ningún efecto para prevenir la inflamación, ni aun en combinación con tetraciclina. Un cuarto grupo se trató con anticuerpos monoclonales dirigidos contra la subpoblación linfocítica L3T4 (equivalente en seres humanos a CD4. En los ratones con L3T4 se observó un agotamiento (depleción total de la población linfocítica L3T4 hacia el segundo día después de la inoculación. El agotamiento persistió por lo menos hasta el día 20, pero no alteró significativamente los porcentajes de células expresadas por Thy 1.2 (célula de antígeno T o Lyt2 (célula de antígeno T supresor/citotóxico, que equivale a los CD8 en el hombre. Se concluye que los continuos inóculos con Chlamydia, generan una respuesta inmune que termina con daño del tejido y conduce a la infertilidad.

  19. Análisis de la reacción inflamatoria y los procesos degenerativos provocados por la inyección intracerebroventricular de neuraminidasa en rata

    OpenAIRE

    Granados-Durán, Pablo

    2014-01-01

    Las infecciones víricas y bacterianas del sistema nervioso central (SNC) y la neuroinflamación han sido relacionadas en los últimos años con en el desarrollo de ciertas enfermedades neurodegenerativas, tales como la esclerosis múltiple, la enfermedad de Alzheimer, la esclerosis lateral amiotrófica o trastornos neurocognitivos como la demencia asociada al VIH o la esquizofrenia. Muchas de estas enfermedades continúan hoy sin tratamiento, incluyendo aquellas que son sospechosas de ser consecuen...

  20. Análisis de la reacción inflamatoria y los procesos degenerativos provocados por la inyección intracerebroventricular de neuraminidasa en rata

    OpenAIRE

    Granados-Durán, Pablo

    2015-01-01

    Las infecciones víricas y bacterianas del sistema nervioso central (SNC) y la neuroinflamación han sido relacionadas en los últimos años con en el desarrollo de ciertas enfermedades neurodegenerativas, tales como la esclerosis múltiple, la enfermedad de Alzheimer, la esclerosis lateral amiotrófica o trastornos neurocognitivos como la demencia asociada al VIH o la esquizofrenia. Muchas de estas enfermedades continúan hoy sin tratamiento, incluyendo aquellas que son sospechosas de ser consecuen...

  1. Cirugía bariátrica en enfermedad inflamatoria intestinal: presentación de un caso clínico y revisión de la literatura

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    Carmen Tenorio Jiménez

    2013-06-01

    Full Text Available La Enfermedad Inflamatoria Intestinal (EII raramente se asocia a obesidad, ya que la malabsorción es una característica frecuente de este grupo de patologías (1. Sin embargo, algunos pacientes pueden padecer obesidad mórbida asociada a complicaciones y refractaria a tratamiento dietético y beneficiarse de la cirugía bariátrica. Incluso se ha postulado que podría producirse una mejoría de la EII al disminuir los marcadores inflamatorios tras la cirugía (2. No obstante, los pacientes pueden experimentar mayor incidencia de complicaciones tras la cirugía en el contexto de terapias inmunosupresoras y agravamiento de la malabsorción previa. Por ello, si se realiza la cirugía, la cuidadosa selección de los pacientes y la individualización de la técnica a realizar son imprescindibles. Presentamos una paciente diagnosticada de Colitis Ulcerosa que presenta desnutrición proteica severa tras cirugía bariátrica tipo derivación bilio-pancreática y realizamos una revisión de la literatura disponible.

  2. Regeneration of Articular Cartilage in Lizard Knee from Resident Stem/Progenitor Cells.

    Science.gov (United States)

    Alibardi, Lorenzo

    2015-09-01

    The epiphysis of femur and tibia in the lizard Podarcis muralis can extensively regenerate after injury. The process involves the articular cartilage and metaphyseal (growth) plate after damage. The secondary ossification center present between the articular cartilage and the growth plate is replaced by cartilaginous epiphyses after about one month of regeneration at high temperature. The present study analyzes the origin of the chondrogenic cells from putative stem cells located in the growing centers of the epiphyses. The study is carried out using immunocytochemistry for the detection of 5BrdU-labeled long retaining cells and for the localization of telomerase, an enzyme that indicates stemness. The observations show that putative stem cells retaining 5BrdU and positive for telomerase are present in the superficial articular cartilage and metaphyseal growth plate located in the epiphyses. This observation suggests that these areas represent stem cell niches lasting for most of the lifetime of lizards. In healthy long bones of adult lizards, the addition of new chondrocytes from the stem cells population in the articular cartilage and the metaphyseal growth plate likely allows for slow, continuous longitudinal growth. When the knee is injured in the adult lizard, new populations of chondrocytes actively producing chondroitin sulfate proteoglycan are derived from these stem cells to allow for the formation of completely new cartilaginous epiphyses, possibly anticipating the re-formation of secondary centers in later stages. The study suggests that in this lizard species, the regenerative ability of the epiphyses is a pre-adaptation to the regeneration of the articular cartilage.

  3. Low-intensity infrared laser effects on zymosan-induced articular inflammatory response

    Science.gov (United States)

    Januária dos Anjos, Lúcia Mara; da Fonseca, Adenilson d. S.; Gameiro, Jacy; de Paoli, Flávia

    2015-03-01

    Low-level therapy laser is a phototherapy treatment that involves the application of low power light in the red or infrared wavelengths in various diseases such as arthritis. In this work, we investigated whether low-intensity infrared laser therapy could cause death by caspase-6 apoptosis or DNA damage pathways in cartilage cells after zymosaninduced articular inflammatory process. Inflammatory process was induced in C57BL/6 mouse by intra-articular injection of zymosan into rear tibio-tarsal joints. Thirty animals were divided in five groups: (I) control, (II) laser, (III) zymosan-induced, (IV) zymosan-induced + laser and (V). Laser exposure was performed after zymosan administration with low-intensity infrared laser (830 nm), power 10 mW, fluence 3.0 J/cm2 at continuous mode emission, in five doses. Twenty-four hours after last irradiation, the animals were sacrificed and the right joints fixed and demineralized. Morphological analysis was observed by hematoxylin and eosin stain, pro-apoptotic (caspase-6) was analyzed by immunocytochemistry and DNA fragmentation was performed by TUNEL assay in articular cartilage cells. Inflammatory process was observed in connective tissue near to articular cartilage, in IV and V groups, indicating zymosan effect. This process was decreased in both groups after laser treatment and dexamethasone. Although groups III and IV presented higher caspase-6 and DNA fragmentation percentages, statistical differences were not observed when compared to groups I and II. Our results suggest that therapies based on low-intensity infrared lasers could reduce inflammatory process and could not cause death by caspase-6 apoptosis or DNA damage pathways in cartilage cells after zymosan-induced articular inflammatory process.

  4. Viscosupplementation with intra-articular hyaluronic acid for treatment of osteoarthritis in the elderly.

    Science.gov (United States)

    Abate, M; Pulcini, D; Di Iorio, A; Schiavone, C

    2010-01-01

    Osteoarthritis (OA) is very disabling condition in the elderly. The current therapeutic approaches (analgesics, NSAIDs, COX-2 inhibitors, steroids) do not delay the OA progression or reverse joint damage. Moreover, they may cause relevant systemic side effects. Hyaluronic acid (HA) is a physiologic component of the synovial fluid and is reduced in OA joints. Therefore, intra-articular injection of HA, due to its viscoelastic properties and protective effect on articular cartilage and soft tissue surfaces of joints, can restore the normal articular homoeostasis. These effects are evident when HA is properly administered into the articular space; therefore, the use of "image-guided" infiltration techniques is mandatory. Viscosupplementation (VS), with different HA preparations (Low and High molecular weight), can be considered when the patient has not found pain relief from other therapies or is intolerant to analgesics or NSAIDs. A 3-5 doses regimen is usually recommended with 1 week interval between each injection. Several studies have shown the efficacy of HA for the treatment of knee OA, with positive effects on pain, articular function (Western Ontario and Mc Master Universities Osteoarthritis Index [WOMAC], Lequesne Index [LI], Range of Motion [ROM]), subjective global assessment and reduction in NSAIDs consumption. In general, the benefit is evident within 3 months and persists in the following 6-12 months. Encouraging but inconclusive results have also been observed for the treatment of shoulder, carpo-metacarpal, hip and ankle OA. However there is the need of better designed studies to prove the effectiveness of these medications, in order to rule out a placebo effect. The therapy is well tolerated with absence of systemic side effects and only with limited local discomfort.

  5. Regeneration of Articular Cartilage in Lizard Knee from Resident Stem/Progenitor Cells

    Directory of Open Access Journals (Sweden)

    Lorenzo Alibardi

    2015-09-01

    Full Text Available The epiphysis of femur and tibia in the lizard Podarcis muralis can extensively regenerate after injury. The process involves the articular cartilage and metaphyseal (growth plate after damage. The secondary ossification center present between the articular cartilage and the growth plate is replaced by cartilaginous epiphyses after about one month of regeneration at high temperature. The present study analyzes the origin of the chondrogenic cells from putative stem cells located in the growing centers of the epiphyses. The study is carried out using immunocytochemistry for the detection of 5BrdU-labeled long retaining cells and for the localization of telomerase, an enzyme that indicates stemness. The observations show that putative stem cells retaining 5BrdU and positive for telomerase are present in the superficial articular cartilage and metaphyseal growth plate located in the epiphyses. This observation suggests that these areas represent stem cell niches lasting for most of the lifetime of lizards. In healthy long bones of adult lizards, the addition of new chondrocytes from the stem cells population in the articular cartilage and the metaphyseal growth plate likely allows for slow, continuous longitudinal growth. When the knee is injured in the adult lizard, new populations of chondrocytes actively producing chondroitin sulfate proteoglycan are derived from these stem cells to allow for the formation of completely new cartilaginous epiphyses, possibly anticipating the re-formation of secondary centers in later stages. The study suggests that in this lizard species, the regenerative ability of the epiphyses is a pre-adaptation to the regeneration of the articular cartilage.

  6. Effects of Chondroitinase ABC-Mediated Proteoglycan Digestion on Decellularization and Recellularization of Articular Cartilage.

    Directory of Open Access Journals (Sweden)

    Catherine A Bautista

    Full Text Available Articular cartilage has a limited capacity to heal itself and thus focal defects often result in the development of osteoarthritis. Current cartilage tissue engineering strategies seek to regenerate injured tissue by creating scaffolds that aim to mimic the unique structure and composition of native articular cartilage. Decellularization is a novel strategy that aims to preserve the bioactive factors and 3D biophysical environment of the native extracellular matrix while removing potentially immunogenic factors. The purpose of this study was to develop a procedure that can enable decellularization and recellularization of intact articular cartilage matrix. Full-thickness porcine articular cartilage plugs were decellularized with a series of freeze-thaw cycles and 0.1% (w/v sodium dodecyl sulfate detergent cycles. Chondroitinase ABC (ChABC was applied before the detergent cycles to digest glycosaminoglycans in order to enhance donor chondrocyte removal and seeded cell migration. Porcine synovium-derived mesenchymal stem cells were seeded onto the decellularized cartilage scaffolds and cultured for up to 28 days. The optimized decellularization protocol removed 94% of native DNA per sample wet weight, while collagen content and alignment were preserved. Glycosaminoglycan depletion prior to the detergent cycles increased removal of nuclear material. Seeded cells infiltrated up to 100 μm into the cartilage deep zone after 28 days in culture. ChABC treatment enhances decellularization of the relatively dense, impermeable articular cartilage by reducing glycosaminoglycan content. ChABC treatment did not appear to affect cell migration during recellularization under static, in vitro culture, highlighting the need for more dynamic seeding methods.

  7. Anatomical study of the ligamentous attachments and articular surfaces of the trapeziometacarpal joint. Consequences on surgical management of its osteoarthrosis.

    Science.gov (United States)

    Maes-Clavier, C; Bellemère, P; Gabrion, A; David, E; Rotari, V; Havet, E

    2014-04-01

    In the goal to optimize conservative surgical techniques of the trapeziometacarpal joint in cases of moderate osteoarthritis, we have defined the relationships between the ligamentous attachments and the articular surfaces onto the trapezium and the first metacarpal bone on the one hand, and the dorsovolar and the transverse diameters of the articular surfaces on the other hand. Thirty-six trapeziometacarpal joints (from 18 fresh cadavers) were studied. They were separated into two groups depending on the macroscopic assessment of chondral disease. Group A included stages I to III (no osteoarthritis or moderate osteoarthritis), group B included stages IV (major cartilage destruction). The dorsovolar and transverse sizes of the articular surfaces were measured. Dorsoradial ligament (DRL), posterior oblique ligament (POL), intermetacarpal ligament (IML), ulnar collateral ligament (UCL) and anterior oblique ligament (AOL) were dissected and the distance between their attachments and the articular surfaces were measured. Group A included 17 joints (71% males) and group B included 19 joints (95% females). For the first metacarpal bone, the average ratio between the dorsovolar diameter and the transverse diameter of metacarpal articular surfaces was significantly higher in group B and the average distance between the ligamentous attachments and the articular surface was more than two millimeters, except for the DRL in group B. For the trapezium, only the posterior ligaments (DRL and POL) of group A were inserted at a mean distance more than two millimeters from the articular surfaces. Dorsovolar length of the metacarpal articular surface was higher for osteoarthritis cases. This difference can be explained by the existence of a palmar osteophyte that was always found in stage IV. Describing a map of the ligamentous attachment distance from the articular surface could help surgeons to avoid the ligamentous injury during minimal osteochondral resection.

  8. Variante faringo-cérvico-braquial del síndrome de Guillain-Barré

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    Iago Pinal-Fernández

    2014-12-01

    Full Text Available El síndrome de Guillain-Barré es una polineuropatía desmielinizante inflamatoria aguda, existiendo variantes locorregionales poco frecuentes como la faringo-cérvico-braquial. Presentamos el caso de un varón de 63 años de edad que acudió a urgencias por debilidad de extremidades superiores y a nivel cervical, con incapacidad para deglutir y masticar, y una insuficiencia respiratoria aguda rápidamente progresiva por debilidad de músculos respiratorios, todo ello secundario a la variante faringo-cérvico-braquial del síndrome de Guillain-Barré. Esta variante, aunque poco frecuente, presenta un patrón clínico y unos criterios diagnósticos bien definidos, importantes de reconocer para poder así iniciar de forma precoz el tratamiento y mejorar el pronóstico, no siempre favorable, de estos pacientes.

  9. A new building block: costo-osteochondral graft for intra-articular incongruity after distal radius fracture.

    Science.gov (United States)

    Tang, Chris Yuk Kwan; Fung, Boris; Poon, T L; Fok, Margaret

    2014-01-01

    Even with the invention of locking plates, intra-articular fractures of distal radius with extreme comminution remain a challenge for orthopaedic surgeons. Osteochondral graft is a potential choice to reconstruct the articular defect. We report a patient who had a fracture of distal radius with costo-osteochondral graft for articular reconstruction which has not yet been described in the English literature. At nine-year follow-up, he was pain free and had full range of movement of the wrist. The authors suggest that costo-osteochondral graft could be an option with satisfactory result.

  10. Actividad fibrinolítica sinovial en caballos adultos y potros con patología articular

    OpenAIRE

    Ribera Townsend, Thaïs

    2012-01-01

    La patología articular en el caballo provoca, a corto o largo plazo, cojera en el caballo y es motivo de importantes pérdidas económicas en el mundo deportivo ecuestre. La fisiopatología articular en el caballo comporta una serie de procesos biopatológicos que, si no se detectan y tratan a tiempo, generan un ciclo catabólico autodestructivo que induce la degradación de los propios tejidos articulares. Estudios de medicina humana hace tiempo que han demostrado mediante la determinación de marc...

  11. Actividad fibrinolítica sinovial en caballos adultos y potros con patología articular

    OpenAIRE

    Ribera Townsend, Thaïs

    2013-01-01

    La patología articular en el caballo provoca, a corto o largo plazo, cojera en el caballo y es motivo de importantes pérdidas económicas en el mundo deportivo ecuestre. La fisiopatología articular en el caballo comporta una serie de procesos biopatológicos que, si no se detectan y tratan a tiempo, generan un ciclo catabólico autodestructivo que induce la degradación de los propios tejidos articulares. Estudios de medicina humana hace tiempo que han demostrado mediante la determinación de marc...

  12. Artritis séptica del pubis en dos deportistas

    Directory of Open Access Journals (Sweden)

    José A. Andrews

    2012-06-01

    Full Text Available La artritis séptica de pubis u osteomielitis púbica es la infección que compromete la sínfisis pubiana y su articulación. Es poco frecuente, representando menos del 1% de las osteomielitis. Afecta más a menudo a atletas jóvenes y a mujeres que se someten a cirugía ginecológica o urológica. Se presenta con fiebre y dolor púbico, irradiado a genitales, que aumenta con la movilización de la cadera lo que produce claudicación de la marcha. Debe hacerse el diagnóstico diferencial con la osteítis del pubis que es una condición inflamatoria estéril. La punción guiada por imagen suele ser necesaria para el diagnóstico diferencial con la osteítis del pubis. El diagnóstico se basa en la clínica apoyada en el aislamiento microbiológico, métodos por imágenes e incremento de las proteínas de fase aguda. Los agentes etiológicos más comúnmente encontrados son Staphylococcus aureus, seguidos de bacilos gram negativos, o pueden ser polimicrobianos en posquirúrgicos. El tratamiento antibiótico se ajusta al germen aislado por cultivo, además de antiinflamatorios y reposo. El desbridamiento quirúrgico se requiere hasta en el 55% de los casos. Se recomiendan antibióticos por 6 semanas. Se presentan dos casos de osteomielitis del pubis por S. aureus, con buena respuesta al tratamiento. Ambos pacientes eran jóvenes y deportistas.

  13. Intra-articular changes precede extra-articular changes in the biceps tendon following rotator cuff tears in a rat model

    Science.gov (United States)

    Peltz, Cathryn D.; Hsu, Jason E.; Zgonis, Miltiadis H.; Trasolini, Nicholas A.; Glaser, David L.; Soslowsky, Louis J.

    2011-01-01

    Background Biceps tendon pathology is common with rotator cuff tears. The mechanisms for biceps changes, and therefore its optimal treatment, are unknown. Our objective was to determine the effect of rotator cuff tears on regional biceps tendon pathology. We hypothesized that histological and compositional changes would appear before organizational changes, both would appear before mechanical changes, and changes would begin at the tendon’s insertion site. Methods Sixty-five Sprague-Dawley rats received either detachment of supraspinatus and infraspinatus tendons or sham surgery. Rats were sacrificed at 1, 4 or 8 weeks for regional measurements of histological, compositional, organizational (1, 4 and 8 weeks) or mechanical properties (4 and 8 weeks only). Results One week following tendon detachments, decreased organization and more rounded cell shape were found in the intra-articular space of the biceps tendon. Aggrecan expression was increased along the entire length of the tendon while all other compositional changes were at the tendon’s proximal insertion into bone only. With time, this disorganization and more rounded cell shape extended the length of the tendon. Organizational and cell shape changes also preceded detrimental mechanical changes, as decreased modulus in the intra-articular space was found after 8 weeks. Conclusions Results support a degenerative component to pathology in the biceps tendon. Additionally, changes resembling a tendon exposed to compressive loading occurring first in the intra-articular space indicate that the biceps tendon plays an increased role as a load bearing structure against the humeral head in the presence of rotator cuff tears. PMID:21816629

  14. Bloqueos diagnóstico-terapéuticos de carillas articulares cervicales Diagnostic-therapeutic cervical facet joint blocks

    Directory of Open Access Journals (Sweden)

    M.L. Franco

    2009-03-01

    Full Text Available El 66% de los adultos experimenta dolor cervical a lo largo de su vida y el 54% lo ha experimentado durante los pasados 6 meses. Sólo el 5% presentará dolor crónico intenso acompañado de incapacidad funcional. El 80% del dolor cervical se produce por lesiones óseas o musculares como consecuencia de la degeneración discal y facetaria, a lo que se pueden sumar agentes externos, como traumatismo, sobrepeso, sobrecargas laborales, estrés, etc. El diagnóstico del dolor cervical se basa, fundamentalmente, en la exploración física y en la clínica del paciente. Ante la presencia de dolor cervical irradiado a nuca, cintura escapulohumeral y miembro superior derecho sin patrón radicular con exploración positiva en carillas articulares, están indicados los bloqueos diagnóstico-terapéuticos de éstas. En el trabajo se describe la anatomía de la región cervical, cuyo conocimiento es imprescindible tanto para garantizar los buenos resultados, como para minimizar los riesgos, así como las indicaciones y práctica de la técnica.Cervical pain is experienced by 66% of adults during their lifetime and by 54% in the previous 6 months. Only 5% will experience intense chronic pain with functional disability. Eighty percent of cervical pain is produced by skeletal or muscular lesions as a result of disc and facet degeneration. External causative agents include trauma, overweight, occupational demands, stress, etc. Diagnosis of cervical pain is mainly based on physical examination and clinical findings. In cervical pain radiating to the neck, scapulohumeral girdle and upper right arm without a radicular pattern and positive examination of the facet joints, diagnostic-therapeutic facet joint blocks are indicated. The present article describes the anatomy of the cervical region. Knowledge of this region is essential to guarantee good results and to minimize risks. The indications and practical features of the technique are also discussed.

  15. Experience of emplying extracorporal shock-wave therapy for treating limb enthesopathies in patients with articular hypermobility syndrome

    OpenAIRE

    2014-01-01

    Purpose: to study the efficiency of extracorporal shock-wave therapy and the affected area orthopedic relief for treating pain syndrome associated with enthesopathies in patients with articular hypermobility syndrome.75 patients with enthesopathies of various localizations and diagnosed articular hypermobility were observed in 2008-2011, their age varying from 35 to 55 years (median age: 37.5±0.4 years). The treatment mode was out-patient, with a shockwave device PIEZOSON-100 (manufacturer: R...

  16. Geometry of the articular facets of the lateral atlanto-axial joints in the case of occipitalization.

    Science.gov (United States)

    Ryniewicz, A M; Skrzat, J; Ryniewicz, A; Ryniewicz, W; Walocha, J

    2010-08-01

    This study investigates if atlanto-occipital fusion affects the size and geometrical configuration of the articular facets of the atlanto-axial joint. Morphometric analysis was performed on the male adult skull, the occipital bone of which is assimilated with the first cervical vertebrae (the atlas). The perimeter, Feret's diameter, surface area, and circularity of the inferior articular fa-cets were measured. However, we did not observe significant bilateral differences in size of the inferior articular facets of the assimilated atlas compared to normal first cervical vertebrae. Geometrical conformation of the articular facets of the atlas and axis was assessed using a coordinate measuring machine (PMM - 12106, Leitz). The results obtained from this machine indicated that the inferior articular facets of the assimilated atlas presented asymmetrical orientation compared to the normal anatomy of the atlas. Hence, in the case of occipitalization, the gap between the articulating facets of the atlas and the axis was measured to be greater than in the normal atlanto-axial joint. Computer assisted tomography was applied to visualise the anatomical relationship between the inferior articular facets of the assimilated atlas and the corresponding facets located on the axis. In this case, radiographic examination revealed that the bilaterally articulating facets (inferior and superior) showed disproportion in their adjustment within the lateral atlanto-axial joints. Thus, we concluded that the fusion of the atlas with the occipital bone altered the geometry of the inferior articular facets of the atlas and influenced the orientation of the superior articular facets of the axis.

  17. Tendinopathy of the long head of the biceps tendon: histopathologic analysis of the extra-articular biceps tendon and tenosynovium

    OpenAIRE

    Streit JJ; Shishani Y; Rodgers M; Gobezie R

    2015-01-01

    Jonathan J Streit,1 Yousef Shishani,1 Mark Rodgers,2 Reuben Gobezie1 1The Cleveland Shoulder Institute, 2Department of Pathology, University Hospitals of Cleveland, Cleveland, OH, USA Background: Bicipital tendinitis is a common cause of anterior shoulder pain, but there is no evidence that acute inflammation of the extra-articular long head of the biceps (LHB) tendon is the root cause of this condition. We evaluated the histologic findings of the extra-articular portion of the LHB tendon an...

  18. Effects of low-intensity pulsed ultrasound in repairing injured articular cartilage

    Institute of Scientific and Technical Information of China (English)

    JIA Xiao-lin; CHEN Wen-zhi; ZHOU Kun; WANG Zhi-biao

    2005-01-01

    Objective: To investigate the effects of low-intensity pulsed ultrasound in repairing injured articular cartilage. Methods: Ten adult New Zealand rabbits with bilateral full-thickness osteochondral defects on the cartilage surface of intercondylar fossas were used in this study. The wounds in the left knees were treated with low-intensity pulsed ultrasound as the experimental group. The right knees received no treatment as the control group. All the animals were killed at 8 weeks after injury and the tissues in the wounds were collected for gross appearance grading, histological grading and proteoglycan quantity. Results: The scores of the gross appearance grades, histological grades and the optical density of toluidine blue of the tissues in the experimental group were significantly higher than those of the controls at 8 weeks after injury (P<0.05). Conclusions: Low-intensity pulsed ultrasound can accelerate the repair of injured articular cartilage.

  19. Closed reduction versus Kapandji-pinning for extra-articular distal radial fractures.

    Science.gov (United States)

    Stoffelen, D V; Broos, P L

    1999-02-01

    In a randomized prospective trial, treatment of extra-articular distal radial fractures by closed reduction and plaster application was compared with Kapandji-pinning. Closed reduction and plaster cast was used in 50 patients, Kapandji-pinning in 48 patients. According to the Cooney score, good and excellent results were found in the closed reduction and plaster cast group in 74%, compared with 75% in the Kapandji-pinning group. After measuring the maintenance of reduction as well as the functional outcome at 1 year follow-up, no statistically significant differences could be found between the two groups. We conclude that both techniques can be used in treating extra-articular fractures of the distal radius.

  20. Andrographolide Enhances Proliferation and Prevents Dedifferentiation of Rabbit Articular Chondrocytes: An In Vitro Study

    Directory of Open Access Journals (Sweden)

    Li-ke Luo

    2015-01-01

    Full Text Available As the main active constituent of Andrographis paniculata that was applied in treatment of many diseases including inflammation in ancient China, andrographolide (ANDRO was found to facilitate reduction of edema and analgesia in arthritis. This suggested that ANDRO may be promising anti-inflammatory agent to relieve destruction and degeneration of cartilage after inflammation. In this study, the effect of ANDRO on rabbit articular chondrocytes in vitro was investigated. Results showed that not more than 8 μM ANDRO did no harm to chondrocytes (P0.05. The viability assay, hematoxylin-eosin, safranin O, and immunohistochemical staining also showed better performances in ANDRO groups. As to the doses, 3 μM ANDRO showed the best performance. The results indicate that ANDRO can accelerate proliferation of rabbit articular chondrocytes in vitro and meanwhile maintain the phenotype, which may provide valuable references for further exploration on arthritis.

  1. Ángulo óptimo articular y ejercicio: bases y aplicaciones

    OpenAIRE

    Pablo Antonio Rubio-Sobrino; Raúl Rodríguez-Casares; Xavier Aguado; Luis M. Alegre

    2012-01-01

    El ángulo óptimo se refiere a la posición articular en la que se produce el pico máximo de momento de fuerza, dentro de la curva ángulo-momento articular. Este parámetro puede utilizarse para estimar las modificaciones en la curva fuerza-longitud de un grupo muscular. El ángulo óptimo puede ser obtenido a partir de medidas en tests isométricos o dinámicos, y esto debe ser tenido en cuenta a la hora de establecer comparaciones. El ángulo óptimo puede ser modificado tanto de forma aguda como cr...

  2. Large Intra-Articular Anterior Cruciate Ligament Ganglion Cyst, Presenting with Inability to Flex the Knee

    Directory of Open Access Journals (Sweden)

    Jake Sloane

    2010-01-01

    Full Text Available A 41-year-old female presented with a 3-month history of gradually worsening anterior knee pain, swelling and inability to flex the knee. Magnetic resonance imaging (MRI revealed a large intra-articular cystic swelling anterior to the anterior cruciate ligament (ACL, extending into the Hoffa's infrapatellar fat pad. Following manipulation under anaesthesia and arthroscopic debridement of the cyst, the patient's symptoms were relieved with restoration of normal knee motion. ACL ganglion cysts are uncommon intra-articular pathological entities, which are usually asymptomatic and diagnosed incidentally by MRI. This is the first reported case of an ACL cyst being so large as to cause a mechanical block to knee flexion.

  3. Interferon beta-1a in chronic inflammatory demyelinating polyneuropathy: case report Interferon beta en polineuropatía crónica inflamatoria desmienlinizante: caso clínico

    Directory of Open Access Journals (Sweden)

    Andrés Maria Villa

    2004-09-01

    Full Text Available Chronic inflammatory demyelinating polyneuropathy (CIDP is an acquired immune-mediated neuropathy. It presents with a course of progression which may be slow and steady or step-wise or relapsing. Sensory ataxic polyneuropathy may be the only clinical manifestation of this disease. Treatment with interferon beta1a (INF beta1a has been tried with different results in patients who were refractory to other, more conventional, immunomodulatory therapies. Here we report on a patient who had a relapsing form of pure sensory ataxic CIDP and who failed to respond to intravenous human immunoglobulin. He was put on INF beta1a for 3 years. During this period he suffered no relapses while his condition stabilized.La polineuropatía crónica inflamatoria desmielinizante (PCID es una neuropatía inmuno-mediada, que presenta un curso clínico primariamente progresivo o en forma de recaídas. Las manifestaciones sensoriales pueden ser su unica forma de expresión clínica. El tratamiento con interferon beta 1a (IFN beta1a ha sido ensayado en varias oportunidades, con diferentes respuestas terapéuticas, en pacientes refractarios a las terapias inmunomoduladoras convencionales. Nosotros comunicamos un paciente con una forma ataxica recurrente de PCID, que no respondió al tratamiento con inmunoglobulina endovenosa. Posteriormente fue tratado con IFN beta 1 a por tres años. Durante el período de seguimiento no mostró nuevas recaídas y su cuadro neurológico se estabilizó.

  4. Manifestações articulares em pacientes com doença de Crohn e retocolite ulcerativa Articular manifestations in patients with Crohn's disease and ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Cristina Costa Duarte Lanna

    2006-06-01

    Full Text Available Os sintomas articulares constituem a manifestação extra-intestinal mais comum em pacientes com doença de Crohn e com retocolite ulcerativa. Reconhecida como artrite colítica, e mais recentemente, artrite enteropática, está classificada como uma das doenças do grupo das espondiloartropatias. Reconhecidamente, há dois padrões de acometimento articular: 1 periférico, habitualmente, associado aos períodos de atividade da doença intestinal e sem associação com o antígeno HLA B27, e 2 axial, caracterizado por espondilite e sacroiliíte, com curso clínico e radiográfico independente da doença intestinal e associado ao HLA B27.Joint involvement is the most commom extraintestinal manifestation in patients with Crohn's disease and ulcerative colitis. The colitic arthritis, lately called enteropathic arthritis, is classified as one of the diseases of the spondyloarthropathies group. There are two patterns of joint involvement: 1 peripheral arthritis, usually coincides with exacerbations of the inflammatory bowel disease and is not associated with the HLA B27 antigen; and 2 axial involvement, characterized by spondylitis and sacroiliitis, which the clinical course is independent of the intestinal disease, and has an association with HLA B27.

  5. Effect of low-level helium-neon laser therapy on histological and ultrastructural features of immobilized rabbit articular cartilage.

    Science.gov (United States)

    Bayat, Mohammad; Ansari, Enayatallah; Gholami, Narges; Bayat, Aghdas

    2007-05-25

    The present study investigates whether low-level helium-neon laser therapy can increase histological parameters of immobilized articular cartilage in rabbits or not. Twenty five rabbits were divided into three groups: the experiment group, which received low-level helium-neon laser therapy with 13J/cm(2) three times a week after immobilization of their right knees; the control group which did not receive laser therapy after immobilization of their knees; and the normal group which received neither immobilization nor laser therapy. Histological and electron microscopic examinations were performed at 4 and 7 weeks after immobilization. Depth of the chondrocyte filopodia in four-week immobilized experiment group, and depth of articular cartilage in seven-week immobilized experiment group were significantly higher than those of relevant control groups (exact Fisher test, p=0.001; student's t-test, p=0.031, respectively). The surfaces of articular cartilages of the experiment group were relatively smooth, while those of the control group were unsmooth. It is therefore concluded that low-level helium-neon laser therapy had significantly increased the depth of the chondrocyte filopodia in four-week immobilized femoral articular cartilage and the depth of articular cartilage in seven-week immobilized knee in comparison with control immobilized articular cartilage.

  6. Innervation and functional characteristics of connective tissues, especially elastic fibers, in human fetal thoracic intervertebral articular capsule and its surroundings.

    Science.gov (United States)

    Shiraishi, Yosuke; Kobayashi, Miya; Yasui, Masaya; Ozaki, Noriyuki; Sugiura, Yasuo

    2003-05-01

    The articular capsules between the thoracic vertebrae, which have physiologically different functions from those of other levels of the vertebrae, have yet to be subjected to neuro-anatomical and fine structural analysis. In the present study, we analyzed serial frozen sections of decalcified thoracic vertebrae in human fetuses, and identified the articular capsule tissue with its unique distribution of elastic fibers. The fine structure of the elastic fibers was studied by transmission electron microscopy. In the early-stage fetus, the fibrous membrane forming the lateral intervertebral articular capsule contained abundant thin elastic fibers consisting of microfibrils. In the late-stage fetus, the lateral capsule of fibrous membrane was occupied by thick elastic fibers. A medial articular capsule, namely the ligamenta flava, contained numerous thick elastic fibers in both early and late-stage fetuses. The distributional differences in nerve fibers between early and late-stage fetuses were determined by immunostaining, using antibodies raised against protein gene product 9.5 (PGP 9.5; ubiquitin carboxyl-terminal hydrolase). Innervation by PGP 9.5 immunoreactive fibers was limited to the areas of the articular capsules near the blood vessels, which may indicate their functional relation with blood flow. No PGP 9.5 immunoreactive fibers were found in the ligamenta flava of the late-stage fetus. Innervation might be directly involved in the development of the intervertebral articular capsules in normal human fetuses.

  7. Viscoelastic properties of bovine articular cartilage attached to subchondral bone at high frequencies

    Directory of Open Access Journals (Sweden)

    Shepherd Duncan ET

    2009-06-01

    Full Text Available Abstract Background Articular cartilage is a viscoelastic material, but its exact behaviour under the full range of physiological loading frequencies is unknown. The objective of this study was to measure the viscoelastic properties of bovine articular cartilage at loading frequencies of up to 92 Hz. Methods Intact tibial plateau cartilage, attached to subchondral bone, was investigated by dynamic mechanical analysis (DMA. A sinusoidally varying compressive force of between 16 N and 36 N, at frequencies from 1 Hz to 92 Hz, was applied to the cartilage surface by a flat indenter. The storage modulus, loss modulus and phase angle (between the applied force and the deformation induced were determined. Results The storage modulus, E', increased with increasing frequency, but at higher frequencies it tended towards a constant value. Its dependence on frequency, f, could be represented by, E' = Aloge (f + B where A = 2.5 ± 0.6 MPa and B = 50.1 ± 12.5 MPa (mean ± standard error. The values of the loss modulus (4.8 ± 1.0 MPa mean ± standard deviation were much less than the values of storage modulus and showed no dependence on frequency. The phase angle was found to be non-zero for all frequencies tested (4.9 ± 0.6°. Conclusion Articular cartilage is viscoelastic throughout the full range of frequencies investigated. The behaviour has implications for mechanical damage to articular cartilage and the onset of osteoarthritis. Storage modulus increases with frequency, until the plateau region is reached, and has a higher value than loss modulus. Furthermore, loss modulus does not increase with loading frequency. This means that more energy is stored by the tissue than is dissipated and that this effect is greater at higher frequencies. The main mechanism for this excess energy to be dissipated is by the formation of cracks.

  8. Contrast Agent-Enhanced Computed Tomography of Articular Cartilage: Association with Tissue Composition and Properties

    Energy Technology Data Exchange (ETDEWEB)

    Silvast, T.S.; Jurvelin, J.S.; Aula, A.S.; Lammi, M.J.; Toeyraes, J. (Dept. of Clinical Neurophysiology, Kuopio Univ. Hospital, Kuopio (Finland))

    2009-01-15

    Background: Contrast agent-enhanced computed tomography may enable the noninvasive quantification of glycosaminoglycan (GAG) content of articular cartilage. It has been reported that penetration of the negatively charged contrast agent ioxaglate (Hexabrix) increases significantly after enzymatic degradation of GAGs. However, it is not known whether spontaneous degradation of articular cartilage can be quantitatively detected with this technique. Purpose: To investigate the diagnostic potential of contrast agent-enhanced cartilage tomography (CECT) in quantification of GAG concentration in normal and spontaneously degenerated articular cartilage by means of clinical peripheral quantitative computed tomography (pQCT). Material and Methods: In this in vitro study, normal and spontaneously degenerated adult bovine cartilage (n=32) was used. Bovine patellar cartilage samples were immersed in 21 mM contrast agent (Hexabrix) solution for 24 hours at room temperature. After immersion, the samples were scanned with a clinical pQCT instrument. From pQCT images, the contrast agent concentration in superficial as well as in full-thickness cartilage was calculated. Histological and functional integrity of the samples was quantified with histochemical and mechanical reference measurements extracted from our earlier study. Results: Full diffusion of contrast agent into the deep cartilage was found to take over 8 hours. As compared to normal cartilage, a significant increase (11%, P<0.05) in contrast agent concentration was seen in the superficial layer of spontaneously degenerated samples. Significant negative correlations were revealed between the contrast agent concentration and the superficial or full-thickness GAG content of tissue (|R|>0.5, P<0.01). Further, pQCT could be used to measure the thickness of patellar cartilage. Conclusion: The present results suggest that CECT can be used to diagnose proteoglycan depletion in spontaneously degenerated articular cartilage with a

  9. In Vivo Dynamic Deformation of Articular Cartilage in Intact Joints Loaded by Controlled Muscular Contractions

    OpenAIRE

    2016-01-01

    When synovial joints are loaded, the articular cartilage and the cells residing in it deform. Cartilage deformation has been related to structural tissue damage, and cell deformation has been associated with cell signalling and corresponding anabolic and catabolic responses. Despite the acknowledged importance of cartilage and cell deformation, there are no dynamic data on these measures from joints of live animals using muscular load application. Research in this area has typically been done...

  10. Polylactate-coated carbon fiber in extra-articular reconstruction of the unstable knee.

    Science.gov (United States)

    King, J B; Bulstrode, C

    1985-06-01

    Fascia lata and carbon fiber were used in identical operations for the correction of a clearly defined knee instability in cases with a follow-up period of about one year. The early results suggest an improvement of the results in the carbon group, but free carbon has been found within the joint despite careful extra-articular implantation. The long-term consequences of this await evaluation.

  11. Intra-articular membranous interposition detected by MRI in developmental dysplasia of the hip

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, W.; Itoi, Eiji; Sato, Kozo [Akita Univ. (Japan). Dept. of Orthopedic Surgery

    2000-12-01

    Intra-articular membranous interposition was detected by MRI in the hip joint with residual subluxation of a girl aged 5 years 10 months. This structure, which had low signal intensity on both T1- and T2-weighted images, separated the femoral head from the acetabulum. Histological examination revealed chondrometaplasia, which suggested that this interposition might be transformed to a surface cartilaginous tissue of the secondary acetabulum often observed in residual subluxation of the hip. (orig.)

  12. Freeze-thaw treatment effects on the dynamic mechanical properties of articular cartilage

    Directory of Open Access Journals (Sweden)

    Muldrew Ken

    2010-10-01

    Full Text Available Abstract Background As a relatively non-regenerative tissue, articular cartilage has been targeted for cryopreservation as a method of mitigating a lack of donor tissue availability for transplant surgeries. In addition, subzero storage of articular cartilage has long been used in biomedical studies using various storage temperatures. The current investigation studies the potential for freeze-thaw to affect the mechanical properties of articular cartilage through direct comparison of various subzero storage temperatures. Methods Both subzero storage temperature as well as freezing rate were compared using control samples (4°C and samples stored at either -20°C or -80°C as well as samples first snap frozen in liquid nitrogen (-196°C prior to storage at -80°C. All samples were thawed at 37.5°C to testing temperature (22°C. Complex stiffness and hysteresis characterized load resistance and damping properties using a non-destructive, low force magnitude, dynamic indentation protocol spanning a broad loading rate range to identify the dynamic viscoelastic properties of cartilage. Results Stiffness levels remained unchanged with exposure to the various subzero temperatures. Hysteresis increased in samples snap frozen at -196°C and stored at -80°C, though remained unchanged with exposure to the other storage temperatures. Conclusions Mechanical changes shown are likely due to ice lens creation, where frost heave effects may have caused collagen damage. That storage to -20°C and -80°C did not alter the mechanical properties of articular cartilage shows that when combined with a rapid thawing protocol to 37.5°C, the tissue may successfully be stored at subzero temperatures.

  13. Intra-articular pathology associated with isolated posterior cruciate ligament injury on MRI

    Energy Technology Data Exchange (ETDEWEB)

    Ringler, Michael D.; Collins, Mark S.; Howe, B.M. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Shotts, Ezekiel E. [NEA Baptist Clinic, Jonesboro, AR (United States)

    2016-12-15

    Unlike with anterior cruciate ligament injury, little is known about the prevalence of intra-articular pathology associated with isolated posterior cruciate ligament (PCL) injury in the knee. The objectives of this study were to characterize and identify the frequency of meniscal tears and osteochondral injuries in these patients, and to see if management might be affected. Altogether, 48 knee MRI exams with isolated PCL tears were evaluated for the presence of: grade and location of PCL tear, meniscal tear, articular chondral lesion, bone bruise, and fracture. Comparisons between PCL tear grade and location, as well as mechanism of injury when known, with the presence of various intra-articular pathologies, were made using the chi-square or Fisher's exact test as appropriate. In all, 69 % of isolated PCL tears occur in the midsubstance, 27 % proximally. Meniscal tears were seen in 25 % of knees, involving all segments of both menisci, except for the anterior horn medial meniscus. Altogether, 23 % had focal cartilage lesions, usually affecting the central third medial femoral condyle and medial trochlea, while 12.5 % of knees had fractures, and 48 % demonstrated bone bruises, usually involving the central to anterior tibiofemoral joint. The presence of a fracture (p = 0.0123) and proximal location of PCL tear (p = 0.0016) were both associated with the hyperextension mechanism of injury. There were no statistically significant associations between PCL tear grade and presence of intra-articular abnormality. Potentially treatable meniscal tears and osteochondral injuries are relatively prevalent, and demonstrable on MRI in patients with isolated acute PCL injury of the knee. (orig.)

  14. The study on the mechanical characteristics of articular cartilage in simulated microgravity

    Science.gov (United States)

    Niu, Hai-Jun; Wang, Qing; Wang, Yue-Xiang; Li, Ang; Sun, Lian-Wen; Yan, Yan; Fan, Fan; Li, De-Yu; Fan, Yu-Bo

    2012-10-01

    The microgravity environment of a long-term space flight may induce acute changes in an astronaut's musculo-skeletal systems. This study explores the effects of simulated microgravity on the mechanical characteristics of articular cartilage. Six rats underwent tail suspension for 14 days and six additional rats were kept under normal earth gravity as controls. Swelling strains were measured using high-frequency ultrasound in all cartilage samples subject to osmotic loading. Site-specific swelling strain data were used in a triphasic theoretical model of cartilage swelling to determine the uniaxial modulus of the cartilage solid matrix. No severe surface irregularities were found in the cartilage samples obtained from the control or tail-suspended groups. For the tail-suspended group, the thickness of the cartilage at a specified site, as determined by ultrasound echo, showed a minor decrease. The uniaxial modulus of articular cartilage at the specified site decreased significantly, from (6.31 ± 3.37)MPa to (5.05 ± 2.98)MPa ( p < 0.05). The histology-stained image of a cartilage sample also showed a reduced number of chondrocytes and decreased degree of matrix staining. These results demonstrated that the 14 d simulated microgravity induced significant effects on the mechanical characteristics of articular cartilage. This study is the first attempt to explore the effects of simulated microgravity on the mechanical characteristics of articular cartilage using an osmotic loading method and a triphasic model. The conclusions may provide reference information for manned space flights and a better understanding of the effects of microgravity on the skeletal system.

  15. 4 mm cannulatedcancellous screws fixation in extra articular distal 1/3 radius fracture - A study

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    M.S. Patil

    2017-01-01

    Full Text Available Background: Distal radius fracture are extremely common and represents 16% of fractures treated by orthopaedic surgeons. Near anatomical reduction with restoration of radial length, radial tilt and ulnar variances are important for good functional results. Cannulated 4 mm long threaded using minimally invasive osteosynthesis technique are less aggressive towards soft tissue covering. It allows immediate range of motion of the wrist while maintaining alignment resulting in rapid and comfortable functional recovery. The objective of this study was to evaluate the clinical, radiological and functional efficacy of 4 mm cannulated screws in the management of extra articular distal radius fracture using the criteria of Gartland and Werley point system. Material & Method: 40 Patients with extra articular distal radius fracture were treated by minimally invasive osteosynthesis technique using 4 mm cannulatedcancellous screws in AL-Ameen Medical College Hospital, Bijapur between Nov 2013 to Oct 2015 which included 19 males and 21 female patients. The duration of follow-up was ranged from 12-18 months. Results: Using Demerit scoring system of Gartland and Werley, we had 45% excellent, 50% good, 0% fair and 5% poor results. As per our results, excellent to good results were found in 95% of patients. Conclusion: Cannulatedcancellous screws fixation is an effective means of fixation in distal 1/3 radius fracture, allowing immediate range of motion of the wrist, resulting in a rapid and comfortable functional recovery while maintaining alignment and bone healing. It has higher degree of purchase when treating extra articular distal radius fracture with poor bone quality. Being minimally invasive with minimal soft tissue dissection, less operative time, cost effective, cannulated screws is a good option for both young and elderly patients with extra articular distal radius fracture.

  16. The study on the mechanical characteristics of articular cartilage in simulated microgravity

    Institute of Scientific and Technical Information of China (English)

    Hai-Jun Niu; Qing Wang; Yue-Xiang Wang; Ang Li; Lian-Wen Sun; Yan Yan; Fan Fan; De-Yu Li; Yu-Bo Fan

    2012-01-01

    The microgravity environment of a long-term space flight may induce acute changes in an astronaut's musculo-skeletal systems.This study explores the effects of simulated microgravity on the mechanical characteristics of articular cartilage.Six rats underwent tail suspension for 14 days and six additional rats were kept under normal earth gravity as controls.Swelling strains were measured using high-frequency ultrasound in all cartilage samples subject to osmotic loading.Site-specific swelling strain data were used in a triphasic theoretical model of cartilage swelling to determine the uniaxial modulus of the cartilage solid matrix.No severe surface irregularities were found in the cartilage samples obtained from the control or tail-suspended groups.For the tail-suspended group,the thickness of the cartilage at a specified site,as determined by ultrasound echo,showed a minor decrease.The uniaxial modulus of articular cartilage at the specified site decreased significantly,from (6.31 ± 3.37) MPa to (5.05 ± 2.98) MPa (p < 0.05).The histology-stained image of a cartilage sample also showed a reduced number of chondrocytes and decreased degree of matrix staining.These results demonstrated that the 14 d simulated microgravity induced significant effects on the mechanical characteristics of articular cartilage.This study is the first attempt to explore the effects of simulated microgravity on the mechanical characteristics of articular cartilage using an osmotic loading method and a triphasic model.The conclusions may provide reference information for manned space flights and a better understanding of the effects of microgravity on the skeletal system.

  17. In vivo kinematics and articular surface congruency of total ankle arthroplasty during gait.

    Science.gov (United States)

    Yamaguchi, Satoshi; Tanaka, Yasuhito; Banks, Scott; Kosugi, Shinichi; Sasho, Takahisa; Takahashi, Kazuhisa; Takakura, Yoshinori

    2012-08-09

    Relatively high rates of loosening and implant failure have been reported after total ankle arthroplasty. Abnormal kinematics and incongruency of the articular surface may cause increased contact pressure and rotational torque applied to the implant, leading to loosening and implant failure. We measured in vivo kinematics of two-component total ankle arthroplasty (TNK ankle), and assessed congruency of the articular surface during the stance phase of gait. Eighteen ankles of 15 patients with a mean age of 75±6 years (mean±standard deviation) and follow-up of 44±38 months were enrolled. Lateral fluoroscopic images were taken during the stance phase of gait. 3D-2D model-image registration was performed using the fluoroscopic image and the implant models, and three-dimensional kinematics of the implant and incongruency of the articular surface were determined. The mean ranges of motion were 11.1±4.6°, 0.8±0.4°, and 2.6±1.5° for dorsi-/plantarflexion, inversion/eversion, and internal/external rotation, respectively. At least one type of incongruency of the articular surface occurred in eight of 18 ankles, including anterior hinging in one ankle, medial or lateral lift off in four ankles, and excessive axial rotation in five ankles. Among the four ankles in which lift off occurred during gait, only one ankle showed lift off in the static weightbearing radiograph. Our observations will provide useful data against which kinematics of other implant designs, such as three-component total ankle arthroplasty, can be compared. Our results also showed that evaluation of lift off in the standard weightbearing radiograph may not predict its occurrence during gait.

  18. Repair of articular cartilage defects in minipigs by microfracture surgery and BMSCs transplantation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To investigate the feasibility of minimal invasive repair of cartilage defect by arthroscope-aided microfracture surgery and autologous transplantation of mesenchymal stem cells. Methods: Bone marrow of minipigs was taken out and the bone marrow derived mesenchymal stem cells (BMSCs) were isolated and cultured to passage 3. Then 6 minipigs were randomly divided into 2 groups with 6 knees in each group. After the articular cartilage defect was induced in each knee. the left defect received microfracture surgery and was injected with 2. 5 ml BMSCs cells at a concentration of 3×107 cells/ml into the articular cavity; while right knee got single microfracture or served as blank control group. The animals were killed at 8 or 16 weeks, and the repair tissue was histologically and immunohistochemically examined for the presence of type Ⅱ collagen and glycosaminoglycans (GAGs) at 8 and 16 weeks. Results:Eight weeks after the surgery, the overlying articular surface of the cartilage defect showed normal color and integrated to adjacent cartilage. And 16 weeks after surgery, hyaline cartilage was observed at the repairing tissues and immunostaining indicated the diffuse presence of this type Ⅱ collagen and GAGs throughout the repair cartilage in the treated defects. Single microfracture group had the repairing of fibro-cartilage, while during the treatment, the defects of blank group were covered with fewer fiber tissues, and no blood capillary growth or any immunological rejection was observed. Conclusion:Microfracture technique and BMSCs transplantation to repair cartilage defect is characterized with minimal invasion and easy operation, and it will greatly promote the regeneration repair of articular cartilage defect.

  19. Fluid collections and juxta-articular cystic lesions of the shoulder: spectrum of MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Mellado, J.M.; Salvado, E.; Camins, A.; Ramos, A.; Sauri, A. [Institut de Diagnostic per la Imatge, Hospital Joan XXIII, Tarragona (Spain); Merino, X. [Institut de Diagnostic per la Imatge, Hospital Vall' Ebron, Barcelona (Spain); Calmet, J. [Orthopaedic Surgery, Hospital Joan XXIII, Carrer Doctor Mallafre Guasch, Tarragona (Spain)

    2002-03-01

    The MR imaging features of fluid collections and juxta-articular cystic lesions of the shoulder are discussed, with special focus on those related to subacromial impingement and rotator cuff tears. Other more unusual fluid collections and cystic lesions are described, including rice-bodies bursitis, idiopathic synovial osteochondromatosis, dialysis-related amyloid arthropathy, hemophilic arthropathy, infectious conditions, non-infectious inflammatory arthritis, and paralabral cysts. (orig.)

  20. Pure waterjet drilling of articular bone: an in vitro feasibility study:

    OpenAIRE

    Biskup, Christian; Dunnen, Steven den; Kerkhoffs, Gino M. M. J.; Kraaij, Gert; Tuijthof, Gabrielle J. M.

    2013-01-01

    The clinical application of waterjet technology for machining tough human tissues, such as articular bone, has advantages, as it produces clean sharp cuts without tissue heating. Additionally, water supply is possible via flexible tubing, which enables minimally invasive surgical access. This pilot study investigates whether drilling bony tissue with pure waterjets is feasible. Water pressures between 20 and 120 MPa with an orifice of 0.6 mm were used to create waterjets to drill blind boring...

  1. Functional anatomy of the equine temporomandibular joint: Collagen fiber texture of the articular surfaces

    OpenAIRE

    Adams, K.; Schulz-Kornas, E; Arzi, B.; Failing, K.; Vogelsberg, J; Staszyk, C

    2016-01-01

    In the last decade, the equine masticatory apparatus has received much attention. Numerous studies have emphasized the importance of the temporomandibular joint (TMJ) in the functional process of mastication. However, ultrastructural and histological data providing a basis for biomechanical and histopathological considerations are not available. The aim of the present study was to analyze the architecture of the collagen fiber apparatus in the articular surfaces of the equine TMJ to reveal ty...

  2. Safety of Intra-Articular Use of Atelocollagen for Enhanced Tissue Repair

    OpenAIRE

    Magarian, Elise M; Vavken, Patrick; Connolly, Susan A; Mastrangelo, Ashley N.; Murray, Martha M.

    2012-01-01

    Collagen is an important biomaterial in intra-articular tissue engineering, but there are unanswered questions about its safety. We hypothesize that the addition of type-I-collagen for primary repair of the Anterior Cruciate Ligament (ACL) might result in a local and systemic reaction in a porcine model after 15 weeks as demonstrated by joint effusion, synovial thickening, elevated intraarticular and systemic leukocyte counts. Further, this reaction might be aggravated by the addition of a pl...

  3. Behavioral Trait of Morningness-Eveningness in Association with Articular and Spinal Diseases in a Population

    OpenAIRE

    2014-01-01

    Earlier studies have revealed that the more the preference to schedule daily activities towards the evening hours is, the higher the odds for a range of health hazards are. Therefore, we wanted to analyze, whether the behavioral trait of morningness-eveningness is associated with articular and spinal diseases or those with musculoskeletal disorders. Participants (n = 6089), as part of the National FINRISK 2007 Study, were derived from the general population, aged 25 to 74 years, living in Fin...

  4. Efecto antiinflamatorio y antioxidante del extracto hidroalcohólico de Petiveria alliacea

    Directory of Open Access Journals (Sweden)

    César Zaa

    2013-06-01

    Full Text Available Los radicales libres y el daño oxidativo están relacionados con la muerte celular, siendo la peroxidación lipídica un mecanismo que lleva a la destrucción oxidativa de la membrana celular. Además, en procesos inflamatorios, uno de los primeros estadios es la permeabilidad vascular incrementada (formación del edema seguido de la extravasación de los fluídos, migración de leucocitos al sitio dañado y liberación de proteínas pro-inflamatorias. Evaluamos el efecto antioxidante y antiinflamatorio para Petiveria alliacea“mucura”. Para el efecto antioxidante, se evaluó la formación de especies reactivas al ácido tiobarbitúrico como indicador de la peroxidación lipídica. Dosis 200mg/mL de Petiveria alliaceadisminuyó significativamente en un 42% los niveles de MDA comparado con el agua (control negativo. En la evaluación antiinflamatoria, se indujo la inflamación por inyección de car-ragenina (solución al 1%, en la parte subplantar de ratones y en la “bolsa de aire subcutánea” de ratas para la inflamación aguda y crónica respectivamente. En la evaluación antiinflamatoria hay una máxima reducción del edema en un 23,26% a las 4 horas del tratamiento. Para la inflamación crónica hay una reducción del 25,9% y 29,5% del peso y volumen del exudado extraído, respectivamente, así como una reducción del 24% de peso de tejido fibroso. Estos resultados evidencian efecto antioxidante y antiinflamatorio de Petiveria alliacea.

  5. The imaging spectrum of peri-articular inflammatory masses following metal-on-metal hip resurfacing

    Energy Technology Data Exchange (ETDEWEB)

    Fang, Christopher S.J.; Ostlere, Simon [Nuffield Orthopaedic Centre, Department of Radiology, Oxford (United Kingdom); Harvie, Paul; Gibbons, Christopher L.M.H.; Whitwell, Duncan [Nuffield Orthopaedic Centre, Department of Orthopaedic Surgery, Oxford (United Kingdom); Athanasou, Nicholas A. [Nuffield Orthopaedic Centre, Department of Pathology, Oxford (United Kingdom)

    2008-08-15

    Resurfacing metal-on-metal hip arthroplasty is increasing in popularity, especially in younger patients. To date, studies indicate that the procedure is associated with a good outcome in the medium-term. Formation of a peri-articuar mass is a rarely reported complication. In this study we analyse the imaging findings in patients with resurfacing implants presenting to our institution with peri-articular masses identified on cross sectional imaging. All patients with documented peri-articular masses following resurfacing arthroplasty were included. The available imaging related to the masses was reviewed and the findings documented along with the patient's demographics. There were 10 patients (13 joints). All patients were female. Patients presented with periprosthetic anterior or posterolateral solid and cystic masses. The anterior masses involved psoas muscle and were predominately solid. The posterolateral masses were predominately cystic. In the three cases with bilateral arthroplasties, masses were detected in both hips. Histology in six cases showed features compatible with a type IV hypersensitivity reaction. The preponderance of females, the bilateral nature of the masses and the histological features suggest that peri-articular masses following resurfacing arthroplasty is due to the metal hypersensitivity. (orig.)

  6. Intra-Articular Corticosteroids in Addition to Exercise for Reducing Pain Sensitivity in Knee Osteoarthritis

    DEFF Research Database (Denmark)

    Soriano-Maldonado, Alberto; Klokker, Louise; Bartholdy, Cecilie

    2016-01-01

    OBJECTIVE: To assess the effects of one intra-articular corticosteroid injection two weeks prior to an exercise-based intervention program for reducing pain sensitivity in patients with knee osteoarthritis (OA). DESIGN: Randomized, masked, parallel, placebo-controlled trial involving 100 particip......OBJECTIVE: To assess the effects of one intra-articular corticosteroid injection two weeks prior to an exercise-based intervention program for reducing pain sensitivity in patients with knee osteoarthritis (OA). DESIGN: Randomized, masked, parallel, placebo-controlled trial involving 100...... the injections all participants undertook a 12-week supervised exercise program. Main outcomes were changes from baseline in pressure-pain sensitivity (pressure-pain threshold [PPT] and temporal summation [TS]) assessed using cuff pressure algometry on the calf. These were exploratory outcomes from a randomized....... The mean group difference in changes from baseline at week 14 was 0.6 kPa (95% CI: -1.7 to 2.8; P = 0.626) for PPT and 384 mm×sec (95% CI: -2980 to 3750; P = 0.821) for TS. CONCLUSIONS: These results suggest that adding intra-articular corticosteroid injection 2 weeks prior to an exercise program does...

  7. Growth differentiation factor-5 stimulates the growth and anabolic metabolism of articular chondrocytes

    Institute of Scientific and Technical Information of China (English)

    Xu Peng; Guo Xiong; Yao Jianfeng; Zhang Yingang; Klaus von der Mark

    2005-01-01

    Objective: To observe the effect of growth differentiation factor-5 (GDF-5) on the growth and anabolic metabolism of articular chondrocytes. Methods: The articular chondrocytes isolated from rats were treated with various concentrations of rmGDF-5, and the growth of chondrocytes measured by MTT assay, the cellular cartilage matrices formation detected sulfated glycosaminoglycan by Alcian blue staining and type Ⅱ collagen by RT-PCR,the collagen phenotypic expression of chondrocytes detected by immunofluorescence. Results: After 7 days culture,MTT assay showed that GDF-5 enhanced the growth of chondrocytes in a dose-dependent manner, RT-PCR showed that GDF-5 clearly induced the synthesis of type Ⅱ collagen because of the col2a1 mRNA band more and more strong in a dose-dependent. Chondrocytes were cultured with GDF-5 for 14 days, the intensity of Alcian blue staining was greatly enhanced, especially, at a high concentration of 1000ng/ml, and GDF-5 enhanced the accumulation of the Alcian blue-stainable material in a concentration-dependent manner and in a does-dependent manner. Chondrocytes were cultured with GDF-5 for 21 days, immunofluorescent staining of type Ⅱ collagen was clear, the type Ⅰ and X collagen were negative. Conclusion: GDF-5 enhanced the growth of mature articular chondrocytes, and stimulated the cellular cartilage matrices formation, but did not change the collagen phenotypic expression of chondrocytes in mono-layer culture.

  8. Growth Differentiation Factor-5 Stimulates the Growth and Anabolic Metabolism of Articular Chondrocytes

    Institute of Scientific and Technical Information of China (English)

    Xu Peng; Yao Jianfeng; Guo Xiong; Zhang Yingang; Klaus von der Mark

    2009-01-01

    Objective: To observe the effect of growth differentiation factor-5 (GDF-5) on the growth and anabolic metabolism of articular chondrocytes. Methods: The articular chondrocytes isolated from rats were treated with various concentrations of rmGDF-5, and the growth of chondrocytes measured by MTr assay, the cellular cartilage matrices formation detected sulfated glycosaminoglycan by Alcian blue staining and type 11 collagen by RT-PCR, the collagen phenotypic expression of chondrocytes detected by immunofluorescence. Results: After 7 days culture, MTF assay showed that GDF-5 enhanced the growth of ehondrocytes in a dose-dependent manner, RT-PCR showed that GDF-5 clearly induced the synthesis of type Ⅱ collagen because of the colal mRNA band more and more strong in a dose-dependent. Chondrocytes were cultured with GDF-5 for 14 days, the intensity of Alcian blue staining was gready enhanced, especially, at a high concentration of 1000ng/ml, and GDF-5 enhanced the accumulation of the Alcian blue-stainable material in a concentration-dependent manner and in a does-dependent manner. Chondrocytes were cultured with GDF-5 for 21 days, immunofluorescent staining of type Ⅱ collagen was clear, the type Ⅰ and Ⅹ collagen were negative. Conclusion: GDF-5 enhanced the growth of mature articular chon-drocytes, and stimulated the cellular cartilage matrices formation, but did not change the collagen phenotypic ex-pression of chondrocytes in mono-layer culture.

  9. Nitrous Oxide sedation for intra-articular injection in juvenile idiopathic arthritis

    Directory of Open Access Journals (Sweden)

    Harel Liora

    2008-01-01

    Full Text Available Abstract Background Intra-articular corticosteroid injection in juvenile idiopathic arthritis (JIA is often associated with anxiety and pain. Recent reports advocate the use of nitrous oxide (NO, a volatile gas with analgesic, anxiolytic and sedative properties. Objective To prospectively evaluate the effectiveness and safety of NO analgesia for intra-articular corticosteroid injection in JIA, and to assess patients and staff satisfaction with the treatment. Methods NO was administered to JIA patients scheduled for joint injection. The patient, parent, physician and nurse completed visual-analog scores (VAS (0–10 for pain, and a 5-point satisfaction scale. Change in heart rate (HR during the procedure was recorded in order to examine physiologic response to pain and stress. Patient's behavior and adverse reactions were recorded. Results 54 procedures (72 joints were performed, 41 females, 13 males; 39 Jewish, 13 Arab; mean age was 12.2 ± 4.7 year. The median VAS pain score for patients, parents, physicians and nurses was 3. The HR increased ≥ 15% in 10 patients. They had higher VAS scores as evaluated by the staff. The median satisfaction level of the parents and staff was 3.0 and 5.0 respectively. Adverse reactions were mild. Conclusion NO provides effective and safe sedation for JIA children undergoing intra-articular injections.

  10. Contact models of repaired articular surfaces: influence of loading conditions and the superficial tangential zone.

    Science.gov (United States)

    Owen, John R; Wayne, Jennifer S

    2011-07-01

    The superficial tangential zone (STZ) plays a significant role in normal articular cartilage's ability to support loads and retain fluids. To date, tissue engineering efforts have not replicated normal STZ function in cartilage repairs. This finite element study examined the STZ's role in normal and repaired articular surfaces under different contact conditions. Contact area and pressure distributions were allowed to change with time, tension-compression nonlinearity modeled collagen behavior in the STZ, and nonlinear geometry was incorporated to accommodate finite deformation. Responses to loading via impermeable and permeable rigid surfaces were compared to loading via normal cartilage, a more physiologic condition, anticipating the two rigid loading surfaces would bracket that of normal. For models loaded by normal cartilage, an STZ placed over the inferior repair region reduced the short-term axial compression of the articular surface by 15%, when compared to a repair without an STZ. Covering the repair with a normal STZ shifted the flow patterns and strain levels back toward that of normal cartilage. Additionally, reductions in von Mises stress (21%) and an increase in fluid pressure (13%) occurred in repair tissue under the STZ. This continues to show that STZ properties of sufficient quality are likely critical for the survival of transplanted constructs in vivo. However, response to loading via normal cartilage did not always fall within ranges predicted by the rigid surfaces. Use of more physiologic contact models is recommended for more accurate investigations into properties critical to the success of repair tissues.

  11. An Innovative Intra-articular Osteotomy in the Treatment of Posterolateral Tibial Plateau Fracture Malunion.

    Science.gov (United States)

    Wang, Yukai; Luo, Congfeng; Hu, Chengfang; Sun, Hui; Zhan, Yu

    2016-07-13

    Posterolateral tibial plateau fractures are not uncommon and the diagnosis can be easily missed. The treatment is technically demanding, which can easily lead to malunion of the posterolateral tibial plateau fracture. Here, we describe an innovative intra-articular osteotomy for the treatment of posterolateral tibial plateau fracture malunion. From 2010 through 2012, 13 patients with a posterolateral tibial plateau fracture malunion were treated in our trauma center. The patients were referred because of instability or knee pain. The instability was confirmed by physical examinations preoperatively. The depression malunion and lower limb alignment were evaluated on X-rays and computed tomography scans. All posterolateral tibial plateau fracture malunions were treated with an innovative intra-articular osteotomy via an extended anterolateral approach. The mean follow-up was 19.6 months (range, 14-28 months). The posterolateral osteotomy healed at an average of 15.1 weeks. The depression malunion was corrected in all patients, which was from 15.4 mm preoperatively to 3.3 mm at 12 months postoperatively. The average Lysholm, Knee Society Score, and visual analog scale scores were 91.7, 92.5, and 0.5, respectively. No loss of reduction, nonunion, or wound infection was observed. An innovative intra-articular osteotomy via an extended anterolateral approach is an effective treatment for posterolateral tibial plateau fracture malunion. The treatment achieved satisfactory functional results and knee stability restoration.

  12. Extreme Postinjection Flare in Response to Intra-Articular Triamcinolone Acetonide (Kenalog).

    Science.gov (United States)

    Young, Porter; Homlar, Kelly C

    2016-01-01

    As intra-articular corticosteroid injections (CSIs) are a common treatment for osteoarthritis, physicians must well understand their potential side effects. Postinjection flares are an acute side effect of intra-articular CSIs, with symptoms ranging from mild joint effusion to disabling pain. The present case involved a severe postinjection flare that occurred after the patient, a 56-year-old woman with moderate osteoarthritis in the left knee, received 2 mL of 1% lidocaine and 2 mL (40 mg) of triamcinolone acetonide (Kenalog). Two hours after injection, she experienced swelling and intense pain in the knee and was unable to ambulate. The knee was aspirated with a return of 25 mL of "butterscotch"-colored fluid. This case is novel in that its acuity of onset, severity of symptoms, and synovial fluid analysis mimicked septic arthritis, which was ultimately ruled out with negative cultures and confirmation of triamcinolone acetonide crystals in the synovial aspirate, viewed by polarized light microscopy. Thus, the patient's reaction represents an acute crystal-induced inflammatory response. Although reactions to an intra-articular CSI of this severity are rare, it is important for treating physicians to inform patients of this potential side effect.

  13. Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity.

    Science.gov (United States)

    Mäkelä, J T A; Korhonen, R K

    2016-06-14

    Modern fibril-reinforced computational models of articular cartilage can include inhomogeneous tissue composition and structure, and nonlinear mechanical behavior of collagen, proteoglycans and fluid. These models can capture well experimental single step creep and stress-relaxation tests or measurements under small strains in unconfined and confined compression. Yet, it is known that in indentation, especially at high strain velocities, cartilage can express highly nonlinear response. Different fibril reinforced poroelastic and poroviscoelastic models were used to assess measured highly nonlinear stress-relaxation response of rabbit articular cartilage in indentation. Experimentally measured depth-dependent volume fractions of different tissue constituents and their mechanical nonlinearities were taken into account in the models. In particular, the collagen fibril network was modeled using eight separate models that implemented five different constitutive equations to describe the nonlinearity. These consisted of linear elastic, nonlinear viscoelastic and multiple nonlinear elastic representations. The model incorporating the most nonlinearly increasing Young׳s modulus of collagen fibrils as a function of strain captured best the experimental data. Relative difference between the model and experiment was ~3%. Surprisingly, the difference in the peak forces between the experiment and the model with viscoelastic collagen fibrils was almost 20%. Implementation of the measured volume fractions did not improve the ability of the model to capture the measured mechanical data. These results suggest that a highly nonlinear formulation for collagen fibrils is needed to replicate multi-step stress-relaxation response of rabbit articular cartilage in indentation with high strain rates.

  14. Conservative treatment of temporomandibular joint osteoarthrosis: intra-articular injection of sodium hyaluronate.

    Science.gov (United States)

    Guarda-Nardini, L; Masiero, S; Marioni, G

    2005-10-01

    Promising short-term results in the treatment of temporomandibular joint osteoarthrosis with intra-articular injections of sodium hyaluronate (SH) have been reported in preliminary studies. The present prospective study compared long-term outcomes of temporomandibular joint SH injections with those of a conventional non-surgical treatment (bite-plane). Data from three groups of 20 patients with degenerative temporomandibular joint disease were considered. Group A underwent one cycle of five injections of 1 mL SH. Group B underwent a bite-plane treatment for at least 6 months. We considered a control group of 20 patients who refused any treatments. The description of the outcomes was based on objective and subjective parameters after a 6-month follow-up. Sodium hyaluronate and bite-plane treatments significantly improved patients conditions in all considered parameters. No significant differences in outcomes were confirmed by the statistical analysis. The tolerability of SH treatment resulted to be significantly higher. The analysis of results of serial controls in the SH treated group disclosed a significant worsening in pain at rest by comparing 1 and 6 months follow-up. Sodium hyaluronate infiltration resulted a valid non-surgical treatment for temporomandibular joint degenerative disease. Five well-tolerated intra-articular SH injections achieved equivalent results to those of a 6 months bite-plane treatment. We did not diagnose any complications of SH intra-articular injections. Longer time follow-up is necessary to determine the stability of SH properties.

  15. Intra-articular injection of tenoxicam following temporomandibular joint arthrocentesis: a pilot study.

    Science.gov (United States)

    Aktas, I; Yalcin, S; Sencer, S

    2010-05-01

    This study examined the clinical and radiological effects of intra-articular tenoxicam injection following arthrocentesis and compared them with arthrocentesis alone in patients with disc displacement without reduction (DDwoR). 24 temporomandibular joints (TMJs) in 21 patients with DDwoR were studied. Patients were divided randomly into Group A in which only arthrocentesis was performed (14 TMJs in 14 patients) and Group AT which received arthrocentesis plus intra-articular injection of tenoxicam (10 TMJs in 7 patients). Patients were evaluated before the procedure, on postoperative day 7, then 2, 3, 4 weeks, and 2, 3, 4, 5, 6 months postoperatively. Intensity of joint pain was assessed using a visual analog scale. Maximum mouth opening was recorded at each follow-up. TMJ sounds and palpation scores were noted as positive or negative. Magnetic resonance imaging (MRI) was performed before and 6 months after treatment in both groups. Disc form, disc location during neutral position, reduction with movement, joint effusion, structures of the articular surfaces, and bone marrow anomalies were evaluated all in MRIs. Both treatments succesfully increased maximum mouth opening and reduced TMJ pain; there were no complications. Difference between the groups was not statistically significant and a larger controlled study is necessary to clarify this use of tenoxicam.

  16. GROWTH DIFFERENTIATION FACTOR-5 STIMULATES THE GROWTH AND ANABOLIC METABOLISM OF ARTICULAR CHONDROCYTES

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Objective To observe the effect of growth differentiation factor-5 (GDF-5) on the growth and anabolic metabolism of articular chondrocytes. Methods The articular chondrocytes isolated from rats were treated with various concentrations of rmGDF-5, and the growth of chondrocytes measured by MTT assay, the cellular cartilage matrices formation detected sulfated glycosaminoglycan by Alcian blue staining and type Ⅱcollagen by RT-PCR. Results After 7 days culture, MTT assay showed that GDF-5 enhanced the growth of chondrocytes in a dose-dependent manner, RT-PCR showed that GDF-5 clearly induced the synthesis of type Ⅱ collagen because of the col2a1 mRNA band more and more strong in a dose-dependent. Chondrocytes were cultured with GDF-5 for 14 days, the intensity of Alcian blue staining was greatly enhanced, especially, at a high concentration of blue-stainable material in a concentration-dependent manner and in a does-dependent manner. Conclusion GDF-5 enhanced the growth of mature articular chondrocytes, and stimulated the cellular cartilage matrices formation in mono-layer culture.

  17. A superficial hyperechoic band in human articular cartilage on ultrasonography with histological correlation: preliminary observations

    Directory of Open Access Journals (Sweden)

    Tae Sun Han

    2015-04-01

    Full Text Available Purpose: To demonstrate the superficial hyperechoic band (SHEB in articular cartilage by using ultrasonography (US and to assess its correlation with histological images. Methods: In total, 47 regions of interest (ROIs were analyzed from six tibial osteochondral specimens (OCSs that were obtained after total knee arthroplasty. Ultrasonograms were obtained for each OCS. Then, matching histological sections from all specimens were obtained for comparison with the ultrasonograms. Two types of histological staining were used: Safranin-O stain (SO to identify glycosaminoglycans (GAG and Masson’s trichrome stain (MT to identify collagen. In step 1, two observers evaluated whether there was an SHEB in each ROI. In step 2, the two observers evaluated which histological staining method correlated better with the SHEB by using the ImageJ software. Results: In step 1 of the analysis, 20 out of 47 ROIs showed an SHEB (42.6%, kappa=0.579. Step 2 showed that the SHEB correlated significantly better with the topographical variation in stainability in SO staining, indicating the GAG distribution, than with MT staining, indicating the collagen distribution (P<0.05, kappa=0.722. Conclusion: The SHEB that is frequently seen in human articular cartilage on high-resolution US correlated better with variations in SO staining than with variations in MT staining. Thus, we suggest that a SHEB is predominantly related to changes in GAG. Identifying an SHEB by US is a promising method for assessing the thickness of articular cartilage or for monitoring early osteoarthritis.

  18. The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes.

    Science.gov (United States)

    Zhong, Leilei; Huang, Xiaobin; Karperien, Marcel; Post, Janine N

    2015-08-14

    Hypertrophic differentiation of chondrocytes is a main barrier in application of mesenchymal stem cells (MSCs) for cartilage repair. In addition, hypertrophy occurs occasionally in osteoarthritis (OA). Here we provide a comprehensive review on recent literature describing signal pathways in the hypertrophy of MSCs-derived in vitro differentiated chondrocytes and chondrocytes, with an emphasis on the crosstalk between these pathways. Insight into the exact regulation of hypertrophy by the signaling network is necessary for the efficient application of MSCs for articular cartilage repair and for developing novel strategies for curing OA. We focus on articles describing the role of the main signaling pathways in regulating chondrocyte hypertrophy-like changes. Most studies report hypertrophic differentiation in chondrogenesis of MSCs, in both human OA and experimental OA. Chondrocyte hypertrophy is not under the strict control of a single pathway but appears to be regulated by an intricately regulated network of multiple signaling pathways, such as WNT, Bone morphogenetic protein (BMP)/Transforming growth factor-β (TGFβ), Parathyroid hormone-related peptide (PTHrP), Indian hedgehog (IHH), Fibroblast growth factor (FGF), Insulin like growth factor (IGF) and Hypoxia-inducible factor (HIF). This comprehensive review describes how this intricate signaling network influences tissue-engineering applications of MSCs in articular cartilage (AC) repair, and improves understanding of the disease stages and cellular responses within an OA articular joint.

  19. Diffusion and near-equilibrium distribution of MRI and CT contrast agents in articular cartilage

    Science.gov (United States)

    Silvast, Tuomo S.; Kokkonen, Harri T.; Jurvelin, Jukka S.; Quinn, Thomas M.; Nieminen, Miika T.; Töyräs, Juha

    2009-11-01

    Charged contrast agents have been used both in vitro and in vivo for estimation of the fixed charge density (FCD) in articular cartilage. In the present study, the effects of molecular size and charge on the diffusion and equilibrium distribution of several magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents were investigated. Full thickness cartilage disks (Ø = 4.0 mm, n = 64) were prepared from fresh bovine patellae. Contrast agent (gadopentetate: Magnevist®, gadodiamide: Omniscan™, ioxaglate: Hexabrix™ or sodium iodide: NaI) diffusion was allowed either through the articular surface or through the deep cartilage. CT imaging of the samples was conducted before contrast agent administration and after 1, 5, 9, 16, 25 and 29 h (and with three samples after 2, 3, 4 and 5 days) diffusion using a clinical peripheral quantitative computed tomography (pQCT) instrument. With all contrast agents, the diffusion through the deep cartilage was slower when compared to the diffusion through the articular surface. With ioxaglate, gadopentetate and gadodiamide it took over 29 h for diffusion to reach the near-equilibrium state. The slow diffusion of the contrast agents raise concerns regarding the validity of techniques for FCD estimation, as these contrast agents may not reach the equilibrium state that is assumed. However, since cartilage composition, i.e. deep versus superficial, had a significant effect on diffusion, imaging of the nonequilibrium diffusion process might enable more accurate assessment of cartilage integrity.

  20. Mechanical Stimulation Protocols of Human Derived Cells in Articular Cartilage Tissue Engineering - A Systematic Review.

    Science.gov (United States)

    Khozoee, Baktash; Mafi, Pouya; Mafi, Reza; Khan, Wasim S

    2017-01-01

    Mechanical stimulation is a key factor in articular cartilage generation and maintenance. Bioreactor systems have been designed and built in order to deliver specific types of mechanical stimulation. The focus has been twofold, applying a type of preconditioning in order to stimulate cell differentiation, and to simulate in vivo conditions in order to gain further insight into how cells respond to different stimulatory patterns. Due to the complex forces at work within joints, it is difficult to simulate mechanical conditions using a bioreactor. The aim of this review is to gain a deeper understanding of the complexities of mechanical stimulation protocols by comparing those employed in bioreactors in the context of tissue engineering for articular cartilage, and to consider their effects on cultured cells. Allied and Complementary Medicine 1985 to 2016, Ovid MEDLINE[R] 1946 to 2016, and Embase 1974 to 2016 were searched using key terms. Results were subject to inclusion and exclusion criteria, key findings summarised into a table and subsequently discussed. Based on this review it is overwhelmingly clear that mechanical stimulation leads to increased chondrogenic properties in the context of bioreactor articular cartilage tissue engineering using human cells. However, given the variability and lack of controlled factors between research articles, results are difficult to compare, and a standardised method of evaluating stimulation protocols proved challenging. With improved standardisation in mechanical stimulation protocol reporting, bioreactor design and building processes, along with a better understanding of joint behaviours, we hope to perform a meta-analysis on stimulation protocols and methods.

  1. T2* mapping of articular cartilage: current status of research and first clinical applications.

    Science.gov (United States)

    Andreisek, Gustav; Weiger, Markus

    2014-01-01

    T2* mapping is a relatively new method for the compositional assessment of the articular cartilage. Typically, a multigradient echo or an ultrashort echo time imaging technique with a range of short and very short echo times is used. In most studies, imaging is performed at a high field strength, that is, 3 and 7 T. Postprocessing includes exponential fitting of relaxation decay and manual region-of-interest-based measurements of T2* times on T2* maps. Detailed analyses of T2* times of articular cartilage have shown distinct T2* components with shorter and longer T2* times. Moreover, there is a zonal distribution with a significant depthwise gradient of T2*, with relatively short times near the osteochondral junction and relatively long times at the cartilage's surface. T2* times of normal articular cartilage at the knee are, when averaged over the whole cartilage thickness and using monoexponential fitting, approximately 20 milliseconds. The results of recent studies have shown a good test-retest as well as interreader and intrareader reliabilities for T2* mapping. This article provides a descriptive review of the current literature, briefly discusses the technique itself, and provides an outlook on future research questions and possible clinical applications.

  2. Measurement of three-dimensional intra-articular kinematics: methodological and interpretation problems.

    Science.gov (United States)

    Baeyens, J-P; Cattrysse, E; Van Roy, P; Clarys, J-P

    Intra-articular kinematics evaluates joint motion in terms of the configuration of the joint. Therefore data are needed concerning joint kinematics as well as joint configuration. We have developed accurate measurement methods for both in vivo and in vitro evaluation. Interpretation of the processed data is more complex than simply setting up a coordinate system based on the joint configuration. Although the description of intra-articular motion in terms of Euler-Cardan or helical angles may be complete, the therapeutic interpretation may be doubtful. Using the the ulno-humeral joint during flexion-extension as an example, we found the combination of helical angles in the directions of extension/external rotation/varus. In the case of the Cardan angles, inconsistent patterns of rotation resulted from a different choice of sequence order and were different from the helical angles. The finite helical axis (FHA) provides a functional representation of the joint movement, i.e. pathways of motion, whereas the sequence dependency of Euler-Cardan angles produces problems in the therapeutic interpretation of the movement. Therefore we believe that an FHA approach should be used in intra-articular kinematics research.

  3. Composite articular cartilage engineered on a chondrocyte-seeded aliphatic polyurethane sponge.

    Science.gov (United States)

    Liu, Yanchun; Webb, Ken; Kirker, Kelly R; Bernshaw, Nicole J; Tresco, Patrick A; Gray, Steven D; Prestwich, Glenn D

    2004-01-01

    To circumvent the reconstructive disadvantages inherent in resorbable polyglycolic acid (PGA)/polylactic acid (PLA) used in cartilage engineering, a nonresorbable, and nonreactive polyurethane sponge (Tecoflex sponge, TS) was studied as both a cell delivery device and as an internal support scaffolding. The in vitro viability and proliferation of porcine articular chondrocytes (PACs) in TS, and the in vivo generation of new articular cartilage and long-term resorption, were examined. The initial cell attachment rate was 40%, and cell density increased more than 5-fold after 12 days of culture in vitro. PAC-loaded TS blocks were implanted into nude mice, became opalescent, and resembled native cartilage at weeks 12 and 24 postimplantation. The mass and volume of newly formed cartilage were not significantly different at week 24 from samples harvested at week 6 or week 12. Safranin O-fast green staining revealed that the specimens from cell-loaded TS groups at week 12 and week 24 consisted of mature cartilage. Collagen typing revealed that type II collagen was present in all groups of tissue-engineered cartilage. In conclusion, the implantation of PAC-TS resulted in composite tissue-engineered articular cartilage with TS as an internal support. Long-term observation (24 weeks) of mass and volume showed no evidence of resorption.

  4. Behavioral trait of morningness-eveningness in association with articular and spinal diseases in a population.

    Directory of Open Access Journals (Sweden)

    Ilona Merikanto

    Full Text Available Earlier studies have revealed that the more the preference to schedule daily activities towards the evening hours is, the higher the odds for a range of health hazards are. Therefore, we wanted to analyze, whether the behavioral trait of morningness-eveningness is associated with articular and spinal diseases or those with musculoskeletal disorders. Participants (n = 6089, as part of the National FINRISK 2007 Study, were derived from the general population, aged 25 to 74 years, living in Finland. Chronotype was assessed based on six items from the original Horne-Östberg Morningness-Eveningness Questionnaire. Information about risk factors and the diagnoses of articular and spinal diseases were based on the self-reported information. Our results suggest that Evening-types have higher odds for articular and spinal diseases as compared with Morning-types, and this risk is heightened especially regarding spinal disease and backache (odds ratios of 1.8 to 2.1, and 1.6 to 1.8, respectively and remains significant after controlling for the sex, age, education, civil status, physical activity, alcohol use, and smoking, and additionally for the body-mass index, insufficient sleep, or depressive symptoms.

  5. Analgesic efficacy of intra-articular morphine after arthroscopic knee surgery in sport injury patients

    Directory of Open Access Journals (Sweden)

    Mitra Yari

    2013-07-01

    Full Text Available BACKGROUND: Anterior Cruciate Ligament (ACL tearing is a common injury among football players. The present study aims to determine the best single-dose of intra-articular morphine for pain relief after arthroscopic knee surgery that, in addition to adequate and long-term analgesia, leads to fewer systemic side effects. METHODS: This clinical trial was conducted on 40 ASA-I athletes. After surgery, all participants received an injection of 20cc of 0.5% intra-articular bupivacaine. In addition, the first control group received a saline injection and 5, 10 and 15 mg of morphine were respectively injected into the joints of the second, third and fourth groups by use of Arthroscopic equipment before the Arthroscopic removal. The amount of pain based on VAS at 1, 2, 4, 6 and 24 hours after surgery, duration of analgesia and the consumption of narcotic drugs were recorded. RESULTS: The VAS scores in the fourth, sixth and twenty-fourth hours after surgery showed a significant difference between the study groups. The average time to the first analgesic request from the bupivacaine plus 15 mg morphine group was significantly longer than other groups and total analgesic requests were significantly lower than other groups. No drowsiness complications were observed in any of the groups in the first 24 hours after injection. CONCLUSION: Application of 15 mg intra-articular morphine after Arthroscopic knee surgery increases the analgesia level as well as its duration (IRCT138902172946N3 .

  6. Contribución al conocimiento del árbol de cirián (Crescentia alata Kunth.) variabilidad, selección, morfología, citogenética y fitoquímica.

    OpenAIRE

    Peralta Valverde, Gabriel

    2012-01-01

    El cirián es un árbol medicinal con frutos esféricos que contiene iridoides y polifenoles los que confieren propiedades anti-inflamatorias, antioxidantes y antimicrobianas. La presente investigación se realizó en la región de Tierra Caliente, Michoacán, México en la Depresión del Balsas, la cual es uno de los refugios pleistocénicos más extensos de Norteamérica y centro de origen y domesticación del maíz; el árbol de cirián, es una especie emblemática de esta región y probablemente constituyó...

  7. Hallazgo de una leucorrea vaginal de carácter no inflamatoria en hembras bovinas. III. Características clínicas y fertilidad (Finding of a vaginal leucorrhea of non-inflammatory character in bovine females. III.Clinical characteristics and fertility)

    OpenAIRE

    Luis O. Alba Gómez; Humberto Casañas Suárez; Enrique A. Silveira Prado; Eduardo Cruz Muñoz; Luis O. Maroto Martín;

    2005-01-01

    El objetivo de este trabajo fue el de demostrar que la leucorrea vaginal no inflamatoria encontrada en algunas hembras bovinas, no afectaba su eficiencia reproductiva. Para esto se utilizaron 159 novillas y 474 vacas de los genotipos ¾ x ¼ y 5/8 x 3/8 Holstein x Cebú, incorporadas al programa de inseminación artificial. En el 13,8 y 10,5% de las novillas y vacas respectivamente se encontraron colecciones de seudoexudados muco-purulentos y purulentos en sus vaginas. Ninguna de las hembras util...

  8. Nutrigenética de la respuesta lipídica, inflamatoria y del metabolismo de la glucosa en pacientes con síndrome metabólico

    OpenAIRE

    Gómez Delgado, Francisco

    2014-01-01

    Introducción: El síndrome metabólico es una enfermedad heterogénea, caracterizada por un bajo grado de inflamación crónica en el que permanecen inciertos los mecanismos responsables de la variabilidad individual en la expresión de sus manifestaciones y en la respuesta que se obtiene tras la intervención dietética. Nuestra hipótesis es que las variaciones en determinados genes candidatos podrían interaccionar con determinados modelos de alimentación modificando la respuesta s...

  9. Caracterización de la respuesta inmunitaria-inflamatoria sistémica a la infección respiratoria aguda. Análisis del patrón de respuesta en pacientes asmático

    OpenAIRE

    Giuffrida Villa, María Josefina

    2011-01-01

    El patrón de citoquinas en pacientes adultos asmáticos con IRA, y su asociación con el agente etiológico y la expresión clínica de la enfermedad aún no han sido bien establecidos. Para estudiar el patrón de citoquinas circulantes proinflamatorias (IL-1[beta], TNF[alfa]), de la inmunidad adaptativa (IL-4, IL-5) y quimiocinas (IL-8, MCP-1 y RANTES) en pacientes con IRA y su asociación con el agente etiológico y la expresión clínica de la enfermedad, se escogieron 39 pacientes con IRA de no más ...

  10. Recepción del evolucionismo en la epistemología jurídica argentina: aspectos de la iusfilosofía bungeana

    OpenAIRE

    Miranda, Marisa Adriana

    2004-01-01

    Siendo el pensamiento del argentino Carlos Octavio Bunge (1875-1918) una cabal expresión de la influencia de la ciencia europea en Latinoamérica, no resulta extraña la traspolación del evolucionismo darwiniano a la explicación de fenómenos sociales y jurídicos que nuestro autor se empeñara en articular a lo largo de su vida Instituto de Historia Argentina Dr. Ricardo Levene

  11. Role of magnetic resonance imaging in the evaluation of articular cartilage in painful knee joint

    Directory of Open Access Journals (Sweden)

    Digish Shah

    2014-01-01

    Full Text Available Aim: The aim of this study was to determine the role of the magnetic resonance imaging (MRI in patients with atraumatic knee pain. Background and Objectives: Knee pain is one of the most common problems faced by people from time immemorial. There is a wide range of disease ranging from traumatic to degenerative causing knee pain in which articular cartilage is involved. Over the past 15 years, MRI has become the premier, first-line imaging study that should be performed in the evaluation of the painful knee in particular in tears of menisci, cruciate and collateral ligaments, osteochondral abnormalities (chondromalacia, osteoarthritis and osteochondral defects, synovial cysts and bone bruises. MRI, by virtue of its superior soft-tissue contrast, lack of ionizing radiation and multiplanar capabilities, is superior to more conventional techniques for the evaluation of articular cartilage. Materials and Methods: A prospective study was carried out on 150 patients in the Department of Radio-diagnosis, Padmashree Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune over a period of 2 years from June 2011 to May 2013. Patients having fracture or dislocations of the knee joint were also excluded from the study. Detailed clinical history, physical and systemic examination findings of all patients were noted in addition to the laboratory investigations. All patients were subjected to radiograph of knee anterior-posterior and lateral view. MRI was performed with Siemens 1.5 Tesla MAGNETOM Avanto machine. Results: In our study of 150 patients with knee pain, articular cartilage defect was found in 90 patients (60%. Out of 90 patients with articular cartilage defect, 30 patients (20% had full thickness cartilage defects. Subchondral marrow edema was seen beneath 30 patients (20% with articular cartilage defects. 32 patients (21.1% had a complex or macerated meniscal tear. Complete anterior cruciate ligament tear was found in seven

  12. Efeitos do resfriamento e aquecimento articular no desempenho funcional do ombro

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    Dayane de Oliveira Estevam

    2015-06-01

    Full Text Available INTRODUÇÃO: Um dos recursos mais utilizados na reabilitação de lesões musculoesqueléticas é a termoterapia por subtração de calor (crioterapia, enquanto a termoterapia por adição de calor é considerada o procedimento mais antigo de reabilitação física. Entretanto, há poucas evidências que tenham investigado os efeitos desses recursos sobre o desempenho de membros superiores. OBJETIVO: Comparar o efeito do resfriamento e do aquecimento articular sobre o desempenho funcional do membro superior. MÉTODOS: Trinta e quatro voluntários (22,23 ± 2,17 anos; 22,39 ± 2,53 kg/m2, de ambos os sexos, foram divididos aleatoriamente em um dos três grupos: 1 grupo crioterapia GCR (n=10: submetidos ao resfriamento articular por compressas frias; 2 grupo termoterapia - GTE (n=10: submetidos ao aquecimento articular por ondas curtas e 3 grupo controle - GCO (n=14, não submetidos a qualquer intervenção. Os voluntários foram avaliados, pré e pós-intervenção, quanto ao desempenho funcional de membros superiores por meio dos testes de estabilidade da extremidade superior em cadeia cinética fechada (TEESCCF e das condições de equilíbrio em apoio bimanual sobre o baropodômetro. Ainda, os voluntários foram avaliados quanto ao desempenho funcional virtual por meio do jogo Mario Kart (Nintendo Wii (r . RESULTADOS: Houve melhora significativa nos valores pós-intervenção no TEESCCF para o GCR (p0,05. Entretanto, na condição de olhos fechados, houve piora de desempenho para GTE (p=0,04 e melhora de desempenho para o GCO (p=0,02. Não houve alteração significativa no desempenho funcional virtual para os três grupos (p>0,05. CONCLUSÃO: Embora não tenha favorecido o desempenho funcional em todos os testes reais e virtuais utilizados, o resfriamento articular foi mais efetivo que o aquecimento articular para manter o desempenho muscular do membro superior, especialmente nas condições de equilíbrio sobre membros superiores na condi

  13. Repairing articular cartilage defects with tissue-engineering cartilage in rabbits

    Institute of Scientific and Technical Information of China (English)

    SONG Hong-xing; LI Fo-bao; SHEN Hui-liang; LIAO Wei-ming; LIU Miao; WANG Min; CAO Jun-ling

    2006-01-01

    Objective: To investigate the effect of cancellous bone matrix gelatin (BMG) engineered with allogeneic chondrocytes in repairing articular cartilage defects in rabbits.Methods: Chondrocytes were seeded onto three-dimensional cancellous BMG and cultured in vitro for 12 days to prepare BMG-chondrocyte complexes. Under anesthesia with 2.5% pentobarbital sodium (1 ml/kg body weight), articular cartilage defects were made on the right knee joints of 38 healthy New Zealand white rabbits (regardless of sex, aged 4-5 months and weighing 2.5-3 kg) and the defects were then treated with 2.5 % trypsin.Then BMG-chondrocyte complex (Group A, n=18 ),BMG ( Group B, n=10), and nothing ( Group C, n=10)were implanted into the cartilage defects, respectively. The repairing effects were assessed by macroscopic, histologic,transmission electron microscopic (TEM) observation,immunohistochemical examination and in situ hybridization detection, respectively, at 2, 4, 8, 12 and 24 weeks after operation.Results: Cancellous BMG was degraded within 8 weeks after operation. In Group A, lymphocyte infiltration was observed around the graft. At 24 weeks after operation, the cartilage defects were repaired by cartilage tissues and the articular cartilage and subchondral bone were soundly healed. Proteoglycan and type Ⅱ collagen were detected in the matrix of the repaired tissues by Safranin-O staining and immunohistochemical staining,respectively. In situ hybridization proved gene expression of type Ⅱ collagen in the cytoplasm of chondrocytes in the repaired tissues. TEM observation showed that chondrocytes and cartilage matrix in repaired tissues were almost same as those in the normal articular cartilage. In Group B, the defects were repaired by cartilage-fibrous tissues. In Group C, the defects were repaired only by fibrous tissues.Conclusions : Cancellous BMG can be regarded as the natural cell scaffolds for cartilage tissue engineering.Articular cartilage defects can be repaired by

  14. Controversies in the management of intra-articular fractures of distal humerus in adults

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    Sudhir Babhulkar

    2011-01-01

    Full Text Available Background: The surgical approach, type of olecranon osteotomy, method of stabilization of osteotomy, type of fracture stabilization, orthogonal vs parallel plate fixation, need for transposition of ulnar nerve, place for primary total elbow replacement, and type of rehabilitation schedule after surgical fracture treatment are the controversial issues in the treatment of complex intra-articular distal humerus fractures (C2 and C3 in adults. Severe comminution, bone loss, and osteoporosis at the site of distal articular fractures of humerus often lead to unsatisfactory results due to inadequate fixation. We hereby report the outcome of a series of intracondylar fractures of the humerus treated by open reduction and internal fixation and discuss the controversies in light of published literature. Materials and Methods: One hundred and eighty-four patients of intra-articular fractures of distal humerus (C2 and C3 were operated by posterior transolecranon approach between January 1980 and December 2008. Initially, in the first part Chevron intra-articular osteotomy (n=108 was performed out of which 94 have been published in another publication. In later second part (1993 onward, extra-articular olecranon osteotomy (n=76 was routinely performed. Both columns were stably fixed by orthogonal methods; (n=174 however, during the last 2 years, in 10 patients with severe comminution with bone loss, stabilization was achieved by parallel plating. The osteotomy was routinely stabilized by tension band wiring with two parallel K-wires introduced up to the anterior ulnar cortex. The results were evaluated by the staging system of Caja et al. at a minimum follow-up of 2 years. Results: In the first part of the study (n=94, there was delayed union in 4% (n=4, with the fracture taking more than 20 weeks for union. There was delayed union of ulnar osteotomy (n=3 and failure of one tension band wiring, requiring revision. Some loss of motion was seen in 20% of

  15. Jürgen Habermas, democracia, inclusión del otro y patriotismo constitucional desde la ética del discurso

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    Jorge Araya Anabalón

    2011-07-01

    Full Text Available El presente trabajo sobre la ética del discurso de Jurgen Habermas, da cuentade las connotaciones y exigencias para una democracia con legitimidad políticay moral en nuestra sociedad. Entendiendo que una democracia radicalno es algo dado por una sola vez y para siempre, sino el resultado de unproceso comunicativo que permite articular intereses distintos, donde estánen juego la identidad, la solidaridad, la inclusión del “otro” y el patriotismoconstitucional, entre otras cosas. Es decir, se puede corregir y recuperar elideario normativo de la democracia moderna reduciendo la hegemonía de laracionalidad instrumental.

  16. Application of dynamic elect roneuro-stimulation at treatment of patients with deformations of dentitions complicated by muscular and articular dysfunction

    OpenAIRE

    2013-01-01

    The purpose: to evaluate the efficacy of dynamic electroneurostimulation in the complex treatment of patients with strains of dentition complicated by muscular and articular dysfunction. Material and methods. A total of 38 patients aged 25 to 49 years with the strains of dentition, complicated by muscular and articular dysfunction. Clinical, radiological and graphical methods have been applied. In the combined treatment of dentition deformities complicated by muscular and articular dysfunctio...

  17. Intra-articular temperatures of the knee in sports – An in-vivo study of jogging and alpine skiing

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    Cerulli Guiliano

    2008-04-01

    Full Text Available Abstract Background Up to date, no information exists about the intra-articular temperature changes of the knee related to activity and ambient temperature. Methods In 6 healthy males, a probe for intra-articular measurement was inserted into the notch of the right knee. Each subject was jogging on a treadmill in a closed room at 19°C room temperature and skiing in a ski resort at -3°C outside temperature for 60 minutes. In both conditions, temperatures were measured every fifteen minutes intra-articulary and at the skin surface of the knee. A possible influence on joint function and laxity was evaluated before and after activity. Statistical analysis of intra-articular and skin temperatures was done using nonparametric Wilcoxon's sign rank sum test and Mann-Whitney's-U-Test. Results Median intra-articular temperatures increased from 31.4°C before activity by 2.1°C, 4°C, 5.8°C and 6.1°C after 15, 30, 45 and 60 min of jogging (all p ≤ 0.05. Median intra-articular temperatures dropped from 32.2°C before activity by 0.5°C, 1.9°C, 3.6°C and 1.1°C after 15, 30, 45 and 60 min of skiing (all n.s.. After 60 minutes of skiing (jogging, the median intra-articular temperature was 19.6% (8.7% higher than the skin surface temperature at the knee. Joint function and laxity appeared not to be different before and after activity within both groups. Conclusion This study demonstrates different changes of intra-articular and skin temperatures during sports in jogging and alpine skiing and suggests that changes are related to activity and ambient temperature.

  18. Diagnostic Value of T-cell Interferon-γ Release Assays on Synovial Fluid for Articular Tuberculosis: A Pilot Study

    Institute of Scientific and Technical Information of China (English)

    Xin-He Cheng; Sai-Nan Bian; Yue-Qiu Zhang; Li-Fan Zhang; Xiao-Chun Shi; Bo Yang; Feng-Chun Zhang

    2016-01-01

    Background:Tuberculosis (TB) remains a major global public health challenge.Articular TB is an important form of extrapulmonary tuberculosis,and its diagnosis is difficult because of the low sensitivity of traditional methods.The aim of this study was to analyze the diagnostic value of T-SPOT.TB on synovial fluid for the diagnosis of articular TB.Methods:Patients with suspected articular TB were enrolled consecutively between August 2011 and December 2015.T-SPOT.TB was performed on both synovial fluid mononuclear cells (SFMCs) and peripheral blood mononuclear cells (PBMCs).The final diagnosis of articular TB was independent of the T-SPOT.TB result.The diagnostic sensitivity,specificity,predictive value,and likelihood ratio of T-SPOT.TB on SFMCs and PBMCs were analyzed.Results:Twenty patients with suspected articular TB were enrolled.Six were diagnosed with articular TB,and 14 patients were diagnosed with other diseases.Sensitivity and specificity were 83% and 86% for T-SPOT.TB on SFMCs,and 67% and 69% for T-SPOT.TB on PBMCs,respectively.The positive predictive value (PPV) and negative predictive value (NPV) of T-SPOT.TB on SFMCs were 71% and 92%,respectively.The PPV and NPV were 50% and 82% for T-SPOT.TB on PBMCs.Conclusion:Sensitivity,specificity,and NPV of T-SPOT.TB on SFMCs appeared higher than that on PBMCs,indicating that T-SPOT.TB on SFMCs might be a rapid and accurate diagnostic test for articular TB.

  19. Atualização em infecções em próteses articulares Update on infections in articular prosthesis

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    Ana Lucia Lei Munhoz Lima

    2010-01-01

    Full Text Available O implante de próteses articulares, principalmente de quadril e joelho, vem se tornando cada vez mais frequente, representando significante redução no desconforto e imensurável melhora na mobilidade dos pacientes. As revisões da literatura mundial revelam que 1 a 5% destas próteses tornam-se infectadas, sendo importante lembrar que, conforme cresce o número de cirurgias para implantação destas próteses, cresce também o número de casos deste tipo de infecção. As bactérias gram-positivas são predominantes nas contaminações das próteses articulares, em especial o Staphylococcus aureus e o Staphylococcus epidermidis. As infecções causadas por bacilos gram-negativos e fungos como Candida sp vêm sendo relatadas com maior frequência em todo o mundo. As infecções de próteses articulares apresentam sinais característicos que podem ser divididos em manifestações agudas (dor severa, febre alta, toxemia, calor, rubor e secreção na ferida operatória e crônicas (dor progressiva, formação de fístulas cutâneas, com drenagem de secreção purulenta, sem febre. O diagnóstico definitivo da infecção deve ser realizado através do isolamento em cultura do micro-organismo obtido a partir da punção do líquido articular, secreção da ferida cirúrgica e materiais colhidos durante desbridamento cirúrgico. É fundamental a cobertura de S.aureus meticilino-resistente, visto a importância epidemiológica deste agente nessas infecções. O tempo total da antibioticoterapia varia de seis semanas a seis meses, sendo que o tratamento deve ser readequado quando necessário, com base nos resultados das culturas colhidas.The implantation of artificial joints, especially the hip and knee, is becoming increasingly common, representing a significant reduction in discomfort and an immeasurable improvement in patient mobility. Reviews of the global literature indicate that 1-5% of these grafts become infected, though it is important to

  20. LA POSICIÓN DE LOS TRATADOS INTERNACIONALES EN EL SISTEMA DE FUENTES DEL ORDENAMIENTO JURÍDICO CHILENO A LA LUZ DEL DERECHO POSITIVO The role of international treaties in the chilean legal system of sources of law in the view of the positive law

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    Eduardo Aldunate Lizana

    2010-01-01

    Full Text Available El presente trabajo intenta articular un modelo que permita explicar la fuerza normativa de los tratados y su posición en el sistema interno de fuentes del derecho, a partir del derecho positivo vigente.This paper tries to develop a positive-law- grounded model for the explanation of the normative forcé of treaties and their position in the national system of sources of law.

  1. Osteotomía valguizante de tibia proximal en el tratamiento del genu varo artrósico

    OpenAIRE

    Eduardo García Pérez; Luís Mena Aymé; Yovanny Ferrer Lozano; Pablo Oquendo Vázquez

    2013-01-01

    Fundamento: la asimilación de fuerzas en una rodilla mal alineada implica dolor, deformidad y disminución del rango de movimiento. La corrección quirúrgica retarda la progresión de la afección degenerativa articular y la realización de una artroplastia total. Objetivo: evaluar los resultados de la osteotomía valguizante de tibia proximal en el tratamiento del genu varo artrósico. Métodos: estudio descriptivo sobre 21 pacientes atendidos en el Servicio de Ortopedia del Hospital Territorial Doc...

  2. DIAGNÓSTICO Y PROPUESTA PARA UNA GESTIÓN INTEGRAL DEL RIESGO EN EL VALLE DE ABURRA: RED RIESGOS

    OpenAIRE

    ARISTIZÁBAL EDIER; VARGAS RICHARD

    2010-01-01

    A partir del análisis de la situación organizacional de las diferentes instituciones en el Valle de Aburrá frente a la reducción de desastres y emergencias asociadas con los fenómenos de origen natural y antrópico, el Área Metropolitana del Valle de Aburrá, como autoridad ambiental y entidad planificadora, hace una propuesta que pretende articular todas las entidades, organizaciones e instituciones públicas y privadas hacia una gestión integral del riesgo, y la cual denominó: Red para la Gest...

  3. Modelo mecánico para el análisis biomecánico del servicio de tenis

    OpenAIRE

    Esperanza Navarro; Cristina López de Subijana Hernández

    2010-01-01

    El propósito de este artículo es plantear un nuevo modelo mecánico del cuerpo, adaptado a los gestos técnicos del tenis. El modelo consta de 28 puntos articulares, en él se definen barras y sólido-rígidos. Dicho modelo permite un estudio del gesto técnico completo. Se analizó un servicio filmado con dos cámaras a 250 fps de una jugadora con ranking WTA mundial 42. Los resulta...

  4. Estudio funcional del asentamiento oclusal post-ortodóncico

    OpenAIRE

    Cordero Acosta, Eugenio María

    2016-01-01

    Falta resumen y palabras clave Introducción: El estudio del periodo de asentamiento oclusal tras el tratamiento ortodóncico ha sido abordado por los investigadores desde una perspectiva morfológica, estudiando los contactos oclusales revelados mediante papel de articular (bien en modelos transferidos a articuladores semiajustables, bien directamente en el paciente, siendo este el caso más frecuente) tanto en máxima intercuspidación como en posiciones excéntricas fijas, y en algunos casos e...

  5. Coeficiente de fricción y mecanismos de degradación superficial en materiales usados para la construcción de implantes de juntas articulares

    Directory of Open Access Journals (Sweden)

    Juan Alejandro Uribe A.

    2004-01-01

    Full Text Available El presente estudio evaluó los materiales más usados en nuestro medio para la fabricación de implantes de juntas articulares, evidenciando los mecanismos de deterioro superficial presentes en tres tribosistemas: a pin de acero AISI 316LVM contra un disco de acero AISI 316L, b pin de acero inoxidable AISI 316LVM contra disco de polietileno de ultra alto peso molecular (UHMWPE y c pin de una aleación Ti6Al4V contra disco de polietileno de ultra alto peso molecular (UHMWPE, con velocidad de deslizamiento de 0.58 m/s y diferentes cargas normales. Se adaptó una máquina de ensayos de desgaste normalizada del tipo pin – disco (norma ASTM G 99, de tal forma que permitiera sumergir el sistema en una solución de suero de sangre de bovino con una concentración de proteínas de 0.03 g/ml, la cual simula el ataque corrosivo al que se ven sometidos los materiales en las juntas implantadas dentro del cuerpo humano. Se midieron la variación de la fuerza y el coeficiente de fricción en el tiempo para estudiar el comportamiento del tribosistema, caracterizando las superficies desgastadas macro y microscópicamente con el fin de identificar los fenómenos de deterioro superficial. La adhesión fue el mecanismo predominante en el deslizamiento de los pares metal – polímero, mientras que la combinación de adhesión y abrasión fue responsable por un daño mucho mayor en el sistema metal-metal.

  6. Evaluación del daño estructural de manos mediante RM en pacientes con artritis reumatoidea temprana, sin evidencia de erosiones radiográficas Assessment of structural damage of hands by MRI in patients with early rheumatoid arthritis, without evidence of erosions in radiography

    OpenAIRE

    Juan C. Spina (h); Silvina Dutruel; Osvaldo Colombo; Federico Badano; Leandro Aliaga; BARREIRA,JUAN C

    2009-01-01

    Introducción: La Artritis Reumatoidea (AR) se caracteriza por la inflamación crónica de las articulaciones, lo que lleva a la destrucción del cartílago articular y del hueso. Aproximadamente el 75% de los pacientes con AR desarrolla erosiones articulares dentro de los dos primeros años de comienzo de los síntomas. La presencia de erosiones tempranas expresa enfermedad más agresiva y se asocia a un pronóstico más desfavorable. Se ha demostrado que el daño erosivo puede observarse en resonancia...

  7. Deslumbramientos del mercado

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    Monique Selim

    2006-07-01

    Full Text Available Con eje en los diferentes aspectos que adopta el actual proceso de mundialización de la lógica del mercado y expansión capitalista, aún en países socialistas, el presente artículo plantea la necesidad de una reflexión antropológica susceptible de articular el surgimiento de nuevas formas de dominación y representación simbólicas. Se discute el aparente efecto de unificación intelectual producido por la hegemonía del mercado respecto de hechos sociales heterogéneos dados en la historia reciente de las sociedades contemporáneas. Así, la renovada atracción que ejercen los nuevos escenarios sociales reconfigurados en virtud de las modalidades específicas de encarnación y operación de los procesos globalizantes, llama al estudio antropológico de las coyunturas. La autora despliega una interpretación del socialismo de mercado, conjunción -siempre en tensión- de un monopolio político estatal y una liberalización del mercado económico. En esta perspectiva se reubica el interés de una antropología del presente en relevar localmente, en este caso en Vietnam del Norte, la conformación de un nuevo mercado de demandas simbólicas, donde la reaparición de las prácticas culturales de comunicación con los antepasados expresa la necesidad de reunificación familiar y reconciliación con los muertos en la "larga guerra".Tendo como eixo os aspectos diferentes que adota o processo atual de mundialização da lógica do mercado e de expansão capitalista, até mesmo nos países socialistas, este artigo propoe a necessidade de uma reflexão antropológica capaz de articular o aparecimento de novas formas de dominação e de representação simbólica. Discute-se o efeito de superfície de unificação intelectual causado pela hegemonia do mercado em fatos sociais diversos em sociedades contemporâneas. Assim, a atração renovada de novos fatos sociais pelos modos específicos de incorporação e operação de processos de globaliza

  8. Efeitos dos glicosaminoglicanos e sulfato de condroitina A sobre a cartilagem articular normal e com doença articular degenerativa em cães Glycosaminoglycans and chondroitin sulphate "A" effects on normal and osteoarthritic articular cartilage in dogs

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    N.T. Vieira

    2010-10-01

    Full Text Available Avaliaram-se os efeitos dos precursores dos glicosaminoglicanos (GAG e do sulfato de condroitina A (SC sobre a histomorfometria da cartilagem articular normal ou de cartilagem de cães com doença articular degenerativa (DAD experimental. Os grupos experimentais constituíram-se de animais com articulação direita normal, que não foi submetida a procedimento cirúrgico, e com articulação esquerda osteoartrótica e que foi submetida à intervenção cirúrgica. Os grupos foram subdivididos em animais com articulação não tratada e tratada, portanto: normais (N (n=5, NGAG (n=5 e NSC (n=4; e osteoartróticos (O (n=5, OGAG (n=5 e OSC (n=4. Secções de cartilagens do fêmur, da tíbia e da patela foram utilizadas neste estudo. Nos normais (N, NGAG e NSC, não se encontraram lesões que caracterizassem a DAD, embora tenha havido diminuição na celularidade nos de NGAG e NSC, em relação a N. Foram observadas alterações em graus variáveis entre os grupos osteoartróticos. Houve redução acentuada dos condrócitos no grupo O em comparação aos normais enquanto os grupos osteoartróticos tratados apresentaram celularidade semelhante aos normais tratados. Estes resultados foram confirmados pela análise do índice de proporção (IP, que se mostrou elevado em O, indicando menor síntese de proteoglicanos. Não houve diferença significativa entre os IPs dos grupos osteoartróticos tratados (OGAG, OSC apesar do comportamento distinto do OSC ao assemelhar-se aos grupos N e NSC. Estes resultados sugeriram que o SC agiu na cartilagem osteoartrótica de maneira mais eficaz, reduzindo a perda de proteoglicanos e estimulando a viabilidade celular e a atividade metabólica.The effects of precursors of glycosaminoglycans (GAG and chondroitin sulphate A (CS on the histomorphometry of normal articular cartilage and with experimental degenerative joint disease (DJD in dogs were evaluated. The groups were constituted as follows: normal joints were not

  9. Anàlisi reològica del líquid sinovial. Contribució del comportament reològic del líquid sinovial a la caracterització dels líquids mecànics i inflamatoris en diferents malalties reumàtiques

    OpenAIRE

    Tena Marsà, Xavier

    2009-01-01

    Descripció del recurs: 3 juny 2010 Precedents: La viscositat del líquid sinovial és inherent al seu contingut en àcid hialurònic. En condicions patològiques s'altera la viscositat en funció del grau d'inflamació articular. Hipòtesi: El comportament reològic del líquid sinovial pot contribuir a classificar un líquid com a inflamatori o mecànic, ser peculiar en alguna malaltia reumàtica i modificar-se amb l'evolució de la malaltia. Objectius: Determinar les característiques reològiques del l...

  10. Artritis psoriásica: Contribuciones al conocimiento de su patogenia, de sus comorbilidades y al perfil de seguridad de su tratamiento

    OpenAIRE

    Busquets Pérez, Noemí

    2014-01-01

    La artritis psoriásica (AP) es una enfermedad articular inflamatoria crónica, seronegativa, asociada a psoriasis. Esta tesis está compuesta por tres artículos publicados en revistas indexadas, sobre diferentes aspectos de la AP. El primer artículo presentado tuvo como objetivo evaluar la prevalencia de psoriasis moderada-grave (P-MG) en pacientes con AP y las relaciones entre la P-MG y otras variables relacionadas con la artritis. La prevalencia de P-MG en la cohorte fue del 31.3% (52 p...

  11. Hyaluronic acid-coated bovine serum albumin nanoparticles loaded with brucine as selective nanovectors for intra-articular injection

    Directory of Open Access Journals (Sweden)

    Chen Z

    2013-10-01

    Full Text Available Zhipeng Chen,* Juan Chen,* Li Wu, Weidong Li, Jun Chen, Haibo Cheng, Jinhuo Pan, Baochang CaiDepartment of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China*These authors contributed equally to this workObjective: To evaluate the potential of hyaluronic acid (HA-coated bovine serum albumin nanoparticles (BSANPs as a novel chondrocyte-targeting drug-delivery nanomedicine.Methods: The HA-BSANPs were characterized by dynamic light scattering, transmission electron microscopy, differential scanning calorimetry, and X-ray diffraction. Fluorescence imaging was used to visualize the distribution of nanoparticles after intra-articular injection. The chondrocyte-targeting efficiency and cellular uptake mechanism of HA-BSANPs were investigated using endocytic inhibitors.Results: HA-BSANPs were successfully prepared with HA coating the surface and amorphous drug in the core. Compared with BSANPs, HA-BSANPs exhibited improved uptake by chondrocytes through a receptor-mediated active uptake mechanism. The endocytosis process of BSANPs and HA-BSANPs involved clathrin-mediated endocytosis, caveolae-mediated endocytosis, and macropinocytosis. No apparent thickening or hyperplasia of the synovium was observed in either BSANPs or HA-BSANPs. The HA-BSANPs could reside in the articular cavity of rats for more than 14 days, which was significantly longer than BSANPs.Conclusion: HA-BSANPs are a promising carrier for articular-related diseases due to elongated articular residence and improved chondrocytic accumulation.Keywords: chondrocyte, intra-articular injection, hyaluronic acid, BSA, nanoparticles

  12. The effects of proteoglycan and type II collagen on T1rho relaxation time of articular cartilage

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Won Seok; Yoo, Hye Jin; Hong, Sung Hwan; Choi, Ja Young [Dept. of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2015-02-15

    To evaluate the effects of proteoglycan and type II collagen within articular cartilage on T1rho relaxation time of articular cartilage. This study was exempted by the institutional and animal review boards, and informed consent was not required. Twelve porcine patellae were assigned to three groups of control, trypsin-treated (proteoglycan-degraded), or collagenase-treated (collagen-degraded). The T1rho images were obtained with a 3 tesla magnetic resonance imaging scanner with a single loop coil. Statistical differences were detected by analysis of variance to evaluate the effects of the enzyme on T1rho relaxation time. Safranin-O was used to stain proteoglycan in the articular cartilage and immunohistochemical staining was performed for type II collagen. Mean T1rho values of the control, trypsin-treated, and collagenase-treated groups were 37.72 +/- 5.82, 57.53 +/- 8.24, and 45.08 +/- 5.31 msec, respectively (p < 0.001). Histology confirmed a loss of proteoglycan and type II collagen in the trypsin- and collagenase-treated groups. Degradation of proteoglycans and collagen fibers in the articular cartilage increased the articular cartilage T1rho value.

  13. In Vivo Dynamic Deformation of Articular Cartilage in Intact Joints Loaded by Controlled Muscular Contractions.

    Directory of Open Access Journals (Sweden)

    Ziad Abusara

    Full Text Available When synovial joints are loaded, the articular cartilage and the cells residing in it deform. Cartilage deformation has been related to structural tissue damage, and cell deformation has been associated with cell signalling and corresponding anabolic and catabolic responses. Despite the acknowledged importance of cartilage and cell deformation, there are no dynamic data on these measures from joints of live animals using muscular load application. Research in this area has typically been done using confined and unconfined loading configurations and indentation testing. These loading conditions can be well controlled and allow for accurate measurements of cartilage and cell deformations, but they have little to do with the contact mechanics occurring in a joint where non-congruent cartilage surfaces with different material and functional properties are pressed against each other by muscular forces. The aim of this study was to measure in vivo, real time articular cartilage deformations for precisely controlled static and dynamic muscular loading conditions in the knees of mice. Fifty and 80% of the maximal knee extensor muscular force (equivalent to approximately 0.4N and 0.6N produced average peak articular cartilage strains of 10.5±1.0% and 18.3±1.3% (Mean ± SD, respectively, during 8s contractions. A sequence of 15 repeat, isometric muscular contractions (0.5s on, 3.5s off of 50% and 80% of maximal muscular force produced cartilage strains of 3.0±1.1% and 9.6±1.5% (Mean ± SD on the femoral condyles of the mouse knee. Cartilage thickness recovery following mechanical compression was highly viscoelastic and took almost 50s following force removal in the static tests.

  14. Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses.

    Science.gov (United States)

    te Moller, N C R; Brommer, H; Liukkonen, J; Virén, T; Timonen, M; Puhakka, P H; Jurvelin, J S; van Weeren, P R; Töyräs, J

    2013-09-01

    Arthroscopy enables direct inspection of the articular surface, but provides no information on deeper cartilage layers. Optical coherence tomography (OCT), based on measurement of reflection and backscattering of light, is a diagnostic technique used in cardiovascular surgery and ophthalmology. It provides cross-sectional images at resolutions comparable to that of low-power microscopy. The aim of this study was to determine if OCT is feasible for advanced clinical assessment of lesions in equine articular cartilage during diagnostic arthroscopy. Diagnostic arthroscopy of 36 metacarpophalangeal joints was carried out ex vivo. Of these, 18 joints with varying degrees of cartilage damage were selected, wherein OCT arthroscopy was conducted using an OCT catheter (diameter 0.9 mm) inserted through standard instrument portals. Five sites of interest, occasionally supplemented with other locations where defects were encountered, were arthroscopically graded according to the International Cartilage Repair Society (ICRS) classification system. The same sites were evaluated qualitatively (ICRS classification and morphological description of the lesions) and quantitatively (measurement of cartilage thickness) on OCT images. OCT provided high resolution images of cartilage enabling determination of cartilage thickness. Comparing ICRS grades determined by both arthroscopy and OCT revealed poor agreement. Furthermore, OCT visualised a spectrum of lesions, including cavitation, fibrillation, superficial and deep clefts, erosion, ulceration and fragmentation. In addition, with OCT the arthroscopically inaccessible area between the dorsal MC3 and P1 was reachable in some cases. Arthroscopically-guided OCT provided more detailed and quantitative information on the morphology of articular cartilage lesions than conventional arthroscopy. OCT could therefore improve the diagnostic value of arthroscopy in equine orthopaedic surgery.

  15. The Role of Computed Tomography in Evaluating Intra-Articular Distal Humerus Fractures.

    Science.gov (United States)

    Nolan, Betsy M; Sweet, Stephan J; Ferkel, Eric; Udofia, Aniebet-Abasi; Itamura, John

    2015-09-01

    Computed tomography (CT) is often used to evaluate intra-articular distal humerus fracture patterns, but it increases radiation exposure and cost. We conducted a study to determine the effect of adding CT evaluation to plain radiographic evaluation on the classification of, and treatment plans for, intra-articular distal humerus fractures. Nine blinded orthopedic surgeons evaluated 30 consecutive fractures for classification and surgical approach. Evaluations were performed first using plain radiographs and then again using the same radiographs plus CT images. Statistical analysis was performed using the κ correlation coefficient and Cramer V testing. We hypothesized that adding CT images to plain radiographs would change the classification and treatment of these fractures and would improve interobserver agreement on classification and treatment. Intraobserver reliability (Cramer V) was fair (.393) for classification and moderate (.426) for treatment. Interobserver reliability (Cohen κ) did not improve with CT: For classification, κ was .21 without CT and .20 with CT; for treatment, κ was .28 without CT and .27 with CT. When classifying the fractures, attending surgeons chose the multiplanar fracture pattern 25.6% of the time without CT, and remained consistent at 23.3% with CT. Trainees chose this fracture pattern much less often without CT than with CT. Use of CT changed the treatment for multiplanar fractures (73.7% lateral approach vs 51.9% posterior approach with olecranon osteotomy). When added to plain radiographic evaluation, CT evaluation changes classification and treatment plans. Interobserver reliability did not improve. Less experienced surgeons were more likely to identify multiplanar fracture patterns with use of CT. We recommend performing CT for all intra-articular distal humerus fractures.

  16. Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis

    Directory of Open Access Journals (Sweden)

    Hanna Przepiera-Będzak

    2016-01-01

    Full Text Available Objectives. In this study, we assessed the extra-articular symptoms in constellation with selected serum cytokines and disease activity in spondyloarthritis (SpA. Patients and Methods. We studied 287 SpA patients: 131 had AS, 110 had PsA, and 46 had SAPHO. We assessed extra-articular symptoms in all cases. In 191 SpA patients, we measured serum interleukin-6 (IL-6, interleukin-18 (IL-18, interleukin-23 (IL-23, endothelin-1 (ET-1, vascular endothelial growth factor (VEGF, and epidermal growth factor (EGF. Results. Patients with acute anterior uveitis (AAU had higher VAS (P=0.0008, BADSDAI (P=0.0001, ASDAS-ESR (P=0.04, CRP (P=0.006, IL-6 (P=0.02, and IL-18 (P=0.03 levels. Patients with inflammatory bowel disease (IBD had higher VAS (P=0.03, CRP (P=0.0009, and IL-6 (P=0.0003 levels. Patients with skin psoriasis had lower VAS (P=0.001 and BASDAI (P=0.00007 levels. Patients with psoriatic onycholysis had lower VAS (P=0.006, BASDAI (P=0.00001, and CRP (P=0.02 and higher IL-23 (P=0.04 levels. Patients with PPP had lower BASDAI (P=0.04 and higher ET-1 (P=0.001 levels. Conclusions. SpA patients with increased serum IL-18 and decreased serum ET-1 had an increased risk of extra-articular symptoms. In SpA patients, increased disease activity was associated with an increased risk of AAU and IBD and a decreased risk of skin psoriasis, psoriatic onycholysis, and PPP.

  17. Forearm articular proportions and the antebrachial index in Homo sapiens, Australopithecus afarensis and the great apes.

    Science.gov (United States)

    Williams, Frank L'Engle; Cunningham, Deborah L; Amaral, Lia Q

    2015-12-01

    When hominin bipedality evolved, the forearms were free to adopt nonlocomotor tasks which may have resulted in changes to the articular surfaces of the ulna and the relative lengths of the forearm bones. Similarly, sex differences in forearm proportions may be more likely to emerge in bipeds than in the great apes given the locomotor constraints in Gorilla, Pan and Pongo. To test these assumptions, ulnar articular proportions and the antebrachial index (radius length/ulna length) in Homo sapiens (n=51), Gorilla gorilla (n=88), Pan troglodytes (n=49), Pongo pygmaeus (n=36) and Australopithecus afarensis A.L. 288-1 and A.L. 438-1 are compared. Intercept-adjusted ratios are used to control for size and minimize the effects of allometry. Canonical scores axes show that the proximally broad and elongated trochlear notch with respect to size in H. sapiens and A. afarensis is largely distinct from G. gorilla, P. troglodytes and P. pygmaeus. A cluster analysis of scaled ulnar articular dimensions groups H. sapiens males with A.L. 438-1 ulna length estimates, while one A.L. 288-1 ulna length estimate groups with Pan and another clusters most closely with H. sapiens, G. gorilla and A.L. 438-1. The relatively low antebrachial index characterizing H. sapiens and non-outlier estimates of A.L. 288-1 and A.L. 438-1 differs from those of the great apes. Unique sex differences in H. sapiens suggest a link between bipedality and forearm functional morphology.

  18. Intra-articular hip injection: does pain relief correlate with radiographic severity of osteoarthritis?

    Energy Technology Data Exchange (ETDEWEB)

    Deshmukh, Ajit J.; Rodriguez, Jose A. [North Shore LIJ Lenox Hill Hospital, Department of Orthopaedic Surgery, New York, NY (United States); Panagopoulos, Georgia [North Shore LIJ Lenox Hill Hospital, Department of Research, New York, NY (United States); Alizadeh, Ahmadreza; Klein, Devon A. [North Shore LIJ Lenox Hill Hospital, Department of Radiology, New York, NY (United States)

    2011-11-15

    Intra-articular injection is being used widely for both diagnostic and therapeutic purposes in the hip. However, its efficacy is not always predictable in patients with hip osteoarthritis (OA). The purpose of this study was to determine whether the degree of radiographic severity of OA was predictive of the response to intra-articular injection of local anesthetic with corticosteroid and to determine the relationship between immediate pain relief resulting from the anesthetic and delayed pain relief resulting from corticosteroid administration. This retrospective study included 217 patients (220 injections) with diagnosis of hip OA who underwent a fluoroscopically guided therapeutic hip injection of local anesthetic and corticosteroid. Hip radiographs were scored using the Kellgren-Lawrence scale. Immediate and delayed pain relief was documented using a visual analog scale. Logistic regression analysis was performed to investigate whether age, gender or radiographic severity of OA were independent predictors of pain relief. Degree of agreement between immediate and delayed response was assessed with the kappa coefficient. Immediate pain relief was reported in 68.2% of hips and delayed relief in 71.4% of hips. A high level of agreement was observed between immediate and delayed pain relief (kappa = 0.80, p < 0.001). 94% of patients reporting immediate relief also reported relief 2 weeks later. Univariate and multivariate analysis revealed that neither gender nor age was related to immediate or delayed pain relief. Only severity of OA (based on radiographic analysis) was observed to be predictive of pain relief. Pain relief following intra-articular hip injection correlated with radiographic severity of OA. This intervention may be of therapeutic and prognostic value in patients awaiting hip arthroplasty. (orig.)

  19. Open Reduction and Internal Fixation of Displaced Calcaneum, Intra-Articular Fractures by Locking Calcaneal Plate

    Science.gov (United States)

    Santosha; Singh, Arambam Mahendra; Waikhom, Sanjib; Pakhrin, Vishal; Mukherjee, Sagnik; Debbarma, Rajkumar; Prashant, Prabhu Shrinivas

    2016-01-01

    Introduction Calcaneal fractures constitute the most common fractures in hindfoot. Lots of controversies exist in the management of calcaneal fractures but now-a-days, it is preferable to perform open reduction and internal fixation and early mobilizatation. Aim To evaluate the functional outcome after open reduction and internal fixation of displaced intra-articular fractures of the calcaneum by locking calcaneal plate. Materials and Methods The study was conducted in the Department of Orthopaedic Surgery from September 2013 to April 2016. Thirty intra-articular fractures of the calcaneum were treated by locking calcaneal plate. Patients were followed up for a period of 24 months. Bohler’s angle was measured in preoperative, immediate Post-operative period and after 2 years, follow-up was compared. Results were evaluated according to American Orthopaedic Foot and Ankle Society (AOFAS) Score. Results After 24 months of follow-up, all 24 patients were available for evaluation. Radiological union was achieved in a mean time of 12.5 weeks. Mean duration of hospital stay was 21 days. Bohler’s angle was significantly higher after 2 years of follow-up when compared with preoperative x-ray. According to the AOFAS, Ankle–Hind foot Scale outcome score results were excellent in 43.3% of the patients, good in 33.3%, fair in 10%, and poor in 13.3% of patients. The mean AOFAS score was 79.9 (Range 49-96). Conclusion Open reduction and internal fixation of intra-articular fractures of the calcaneum with locking calcaneal plate gives good results. Maintenance of calcaneal height and Bohler’s angle helps to decrease the incidence of subtalar arthritis. PMID:28208957

  20. In Vivo Dynamic Deformation of Articular Cartilage in Intact Joints Loaded by Controlled Muscular Contractions.

    Science.gov (United States)

    Abusara, Ziad; Von Kossel, Markus; Herzog, Walter

    2016-01-01

    When synovial joints are loaded, the articular cartilage and the cells residing in it deform. Cartilage deformation has been related to structural tissue damage, and cell deformation has been associated with cell signalling and corresponding anabolic and catabolic responses. Despite the acknowledged importance of cartilage and cell deformation, there are no dynamic data on these measures from joints of live animals using muscular load application. Research in this area has typically been done using confined and unconfined loading configurations and indentation testing. These loading conditions can be well controlled and allow for accurate measurements of cartilage and cell deformations, but they have little to do with the contact mechanics occurring in a joint where non-congruent cartilage surfaces with different material and functional properties are pressed against each other by muscular forces. The aim of this study was to measure in vivo, real time articular cartilage deformations for precisely controlled static and dynamic muscular loading conditions in the knees of mice. Fifty and 80% of the maximal knee extensor muscular force (equivalent to approximately 0.4N and 0.6N) produced average peak articular cartilage strains of 10.5±1.0% and 18.3±1.3% (Mean ± SD), respectively, during 8s contractions. A sequence of 15 repeat, isometric muscular contractions (0.5s on, 3.5s off) of 50% and 80% of maximal muscular force produced cartilage strains of 3.0±1.1% and 9.6±1.5% (Mean ± SD) on the femoral condyles of the mouse knee. Cartilage thickness recovery following mechanical compression was highly viscoelastic and took almost 50s following force removal in the static tests.

  1. POSSIBILITIES OF CURRENT CELLULAR TECHNOLOGIES FOR ARTICULAR CARTILAGE REPAIR (ANALYTICAL REVIEW

    Directory of Open Access Journals (Sweden)

    M. S. Bozhokin

    2016-01-01

    Full Text Available Despite a wide variety of surgical procedures utilized in clinical practice for treatment of articular cartilage lesions, the search for other options of articular reconstruction remains a relevant and open issue at the current stage of medicine and biotechnologies development. The recent years demonstrated a strong belief in cellular methods of hyaline cartilage repair such as implantation of autologous chondrocytes (ACI or cultures of mesenchymal stem cells (MSC including techniques for genetic modification of cells.The purpose of presented review is to summarize the published scientific data on up to date results of perspective cellular technologies for articular cartilage repair that are being developed. Autologous chondrocyte transplantation originally performed by Swedish researchers in 1987 is considered the first clinically applied technique for restoration of hyaline cartilage using cellular technologies. However, the transplanted cell culture featured low proliferative capacity and inability to form a regenerate resistant to high physical activity. Another generation of methods originated at the turn of the century utilized mesenchymal stem cells instead of autologous chondrocytes. Preparation of MSCs is a less invasive procedure compared to chondrocytes harvesting and the culture is featured by a higher proliferative ability. Researchers use various biodegradable carriers (matrices to secure cell fixation. Despite good clinical mid-term outcomes the transplanted tissue-engineering structures deteriorate with time due to cellular de-differentiation. Next generation of techniques being currently under pre-clinical studies is featured by the preliminary chondrogenic modification of transplanted cell culture. Usage of various growth factors, modified cell product and gene-activated matrices allow to gain a stable regulatory and key proteins synthesis and achieve a focused influence on regenerate's chondrogenic proliferation and in result

  2. Intra-articular block for knee arthroscopy: a study on 41 patients

    Directory of Open Access Journals (Sweden)

    Emami A

    2009-07-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: During recent three decades, parallel to the improvement of arthroscopic techniques, intra-articular block by direct injection of anesthetics into the joint has been used in knee arthroscopy. In this study the efficacy of intra- articular block by complex of bupivacaine, lidocaine and adrenaline in knee arthroscopy has been assessed. "n"nMethods: Forty one healthy adults (age range: 18-55 years with knee problems selected for diagnostic arthroscopy. Anesthesia was induced by direct injection of 10ml 2% bupivacaine, 10ml 0.5% lidocaine plus 1/100000 adrenaline into the knee joint.  Duration of operation and volume of serum used for irrigation during the procedure; pain and analgesics requirement, during and after arthroscopy; VAS (Visual Analogue Scale score, at time of discharge from recovery and also patient's and surgeon's satisfaction were assessed. "n"n Results: Sixty eight percent and 29% of cases reported mild and moderate degree of pain perception during arthroscopy, respectively, and only one case for which general anesthesia was performed, reported severe pain. VAS mean was 2.78. Seventy eight percent of cases and the surgeon in 80% of procedures had excellent or good satisfaction with

  3. Intra-articular nodular fasciitis of the knee: a rare cause of recurrent hemarthrosis.

    Science.gov (United States)

    Matsuzaki, Tokio; Akisue, Toshihiro; Kishimoto, Kenta; Kishimoto, Shin-ichiro; Imabori, Masaya; Hara, Hitomi; Okada, Yoshiyuki; Hitora, Toshiaki; Kuroda, Ryosuke; Kurosaka, Masahiro; Yamamoto, Tetsuji

    2012-06-01

    A 20-year-old man presented with pain and recurrent hemarthrosis in the right knee. Magnetic resonance imaging of the knee showed a lesion with homogeneous low signal intensity on T1-weighted images and a heterogeneous, low to high signal intensity on T2-weighted images. At arthroscopy, the mass was located between the posterior cruciate ligament and the posterior knee joint capsule. The tumor was excised through a posterior approach and histologically diagnosed as a nodular fasciitis. Intra-articular nodular fasciitis is a very rare clinicopathologic entity. The current case showed the unique clinical feature of recurrent hemarthrosis at initial presentation, which has not been previously reported.

  4. An intra-articular ganglion cyst in a patient with juvenile idiopathic arthritis.

    Science.gov (United States)

    Deng, Donna Y; Yee, Keolamau; Burkhalter, William; Okimoto, Kelley Chinen; Kon, Kevin; Kurahara, David K

    2014-01-01

    We report an intra-articular ganglion cyst (IAGC) presenting as knee pain and a mass in a patient with longstanding Juvenile Idiopathic Arthritis (JIA). We could not find a similar case of an IAGC occurring in the knee of JIA patients in the literature. IAGC may need to be included as a possibility in patients with inflammatory arthritis with new-onset knee pain, especially in those with a palpable mass. MRI was useful in distinguishing IAGC from more worrisome causes of a knee mass. Orthopedic input was helpful in diagnosis and treatment. In addition, methotrexate therapy was effective in bringing about a long-lasting remission.

  5. Alterações hemoglobinicas e manifestações osteo-articulares

    OpenAIRE

    1981-01-01

    Resumo: Tendo em vista a importância da hemoglobina S em nossas populações, é lamentável que a literatura nacional disponha de poucos dados a respeito da participação das síndromes falcêmicas (anemia falciforme, hemoglobinopatia SC, microdrepanocitose, traço siclêmico, etc.) na etiologia das does ósteo-articulares em nosso meio. No presente trabalho, a presença da hemoglobina S e de outras alterações hemoglobínicas foi investigada em uma amostra de 200 pacientes (126 negróides e 74 caucasóide...

  6. Functional bracing for comminuted extra-articular fractures of the distal third of the humerus.

    Science.gov (United States)

    Sarmiento, A; Horowitch, A; Aboulafia, A; Vangsness, C T

    1990-03-01

    From 1982 to 1987 we treated 85 extra-articular comminuted distal third humeral fractures in adults with prefabricated plastic braces. Of these, 15% were open fractures and 18% had initial peripheral nerve injury. On average, the sleeve was applied 12 days after injury and used for 10 weeks. There was 96% union, with no infections. All nerve injuries resolved or were improving at the latest examination. At union there was varus deformity averaging 9 degrees in 81% of patients, but loss of range of movement was minimal and functional results were good.

  7. MRI findings in injured articular cartilage of the knee correlated with surgical findings

    Institute of Scientific and Technical Information of China (English)

    LI Xiao-ming; PENG Wen-jia; WU Hua; Kacher Daniel; XIA Li-ming; AI Fei; LI Feng; XIONG Wei

    2009-01-01

    Background There is a strong need for quick noninvasive diagnostic technique that can give a valid estimate of the status of the cartilage reliably,discriminating intact cartilage from various grades of impaired cartilage.The goal of this study was to assess the incidence of knee cartilage injuries and compare the accuracy of two-dimension spin echo(2D SE)and fast spin echo(FSE)(conventional MRI),three-dimensional spoiled gradient echo(3D SPGR),three-dimensional fast imaging employing steady state acquisition(3D FIESTA)MR imaging sequences with surgical examination of the articular cartilage.Methods One hundred and thirty-eight knees with history of knee trauma received conventional MRI,3D SPGR and 3D FIESTA MRI examination before surgery,and surgical examination of articular cartilage was used as reference standard.A modified version of the Noyes classification system was applied for the evaluation of the lateral femoral condyle(LFC),medial femoral condyle(MFC),lateral tibial plateau(LTP),medial tibial plateau(MTP),trochlea and patella.The incidence and distributions of different injured grades at different articular surfaces of knee were assessed.A series of assessment indeces of 3D SPGR,3D FIESTA,and the combination of the conventional MRI and 3D SPGR imaging were calculated.Results The incidence of cartilage defects(grade 2 to 4)was 22%(183/828),according to surgical examination.Grade 3 and 4 lesions were absent at the medial tibial plateau.The rates of exact match between the grading results of different MRI procedures and surgical examination were 49% of 3D SPGR,61% of 3D FIESTA,and 82% of the combination of 3D SPGR and conventional MRI.Also,the combination of 3D SPGR and conventional MR imaging provided the highest sensitivity,specificity,accuracy,positive and negative predictive values,at 71%,97%,90%,90% and 90%,respectively.Conclusions For all the articular surfaces of the traumatic knees,about one fifth(22%)were cartilage defects.Both 3D SPGR and 3D

  8. Benign osseous and articular abnormalities of the pelvis: a review of CT imaging findings.

    Science.gov (United States)

    Belfi, Lily M; Bartolotta, Roger J; Loftus, Michael L; Wladyka, Christopher; Hentel, Keith D

    2015-01-01

    Computed tomography (CT) has become the standard of care for evaluation and follow-up for a wide range of abdominal and pelvic pathology. Many incidental osseous and articular abnormalities of the pelvis are detected on these studies, most of which have a benign etiology. However, most of these studies are interpreted by nonmusculoskeletal radiologists, who may not be familiar with the CT appearances of these benign musculoskeletal abnormalities. Uncertainty often leads to mischaracterization or unnecessary follow-up, resulting in increased health care costs and patient anxiety. This article reviews the CT appearance of the benign musculoskeletal entities that occur in pelvis.

  9. Doença articular degenerativa da articulação temporomandibular

    OpenAIRE

    Carvalho, Joana Alexandra Alves de

    2009-01-01

    Monografia apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Medicina Dentária Este trabalho foi desenvolvido com o intuito de abordar diversas questões relacionadas com o desenvolvimento da Doença Articular Degenerativa (DAD) ao nível da Articulação Temporomandibular (ATM). Os eventos moleculares que estão na base da patogénese da DAD da ATM e as artralgias associadas são complexos. Modelos contemporâneos sugerem que excessivas ...

  10. Traumatic atlantoaxial rotatory fixation associated with C2 articular facet fracture in adult patient: Case report

    Directory of Open Access Journals (Sweden)

    Mehdi Bellil

    2014-01-01

    Full Text Available Traumatic atlantoaxial rotatory fixation is a very rare injury in adults which is often misdiagnosed initially. Its combination with C2 fractures is predominated by dens lesions. Therapeutic management is challenging because of the difficulty to achieve optimal reduction and permanent stability. We report a rare case of traumatic atlantoaxial rotatory fixation in a 56-year-old women associated with C2 articular facet fracture successfully treated by conservative means after patient-awake manual reduction with optimal functional and radiographic outcome.

  11. Hypersensitivity to mechanical and intra-articular electrical stimuli in persons with painful temporomandibular joints

    DEFF Research Database (Denmark)

    Ayesh, Emad; Jensen, Troels Staehelin; Svensson, P

    2007-01-01

    This study tested whether persons with TMJ arthralgia have a modality-specific and site-specific hypersensitivity to somatosensory stimuli assessed by quantitative sensory tests (QST). Forty-three healthy persons and 20 with TMJ arthralgia participated. The QST consisted of: sensory and pain...... detection thresholds and summation threshold to intra-articular electrical stimulation, tactile and pin-prick sensitivity in the TMJ area, pressure-pain threshold and tolerance on the lateral side of the TMJ and on the finger. Persons with TMJ arthralgia had lower pain detection and summation thresholds (P...

  12. Arthroscopic Excision of Juxta-articular Osteoid Osteoma of the Calcaneum

    Science.gov (United States)

    Tauheed, Mohammed; Korula, Ravi Jacob; Shankarnarayanan, Sriram

    2016-01-01

    Osteoid osteoma of the foot is a rare condition particularly of the calcaneum. This condition is difficult to diagnose and is more difficult to treat particularly if it involves deeper part of the joints. We present an arthroscopic technique to deal with a case of juxta-articular osteoid osteoma of the calcaneum using two portals: the anterolateral portal for instrumentation and the anterior anterolateral portal for visualization of the subtalar joint. Because this approach is minimally invasive, it offers early recovery and reduced morbidity compared with the conventional techniques. PMID:27073769

  13. LA LÓGICA DEL MERCADO Y EL COMPORTAMIENTO ÉTICO DE LA EMPRESA

    OpenAIRE

    1999-01-01

    El presente ensayo tiene como finalidad abordar el concepto de la Responsabilidad social dela empresa y como está evolucionando en el transcurso del tiempo hasta desembocar en la obligación existencial de la empresa de articular relaciones que sobrepasan el paradigma de la simplicidad y que se aborde la interacción con la sociedad civil desde una perspectiva multidimensional. Sin embargo, desde la perspectiva de la lógica del mercado no es fácil que la empresa capte las permutaciones que los ...

  14. Efectividad del vendaje neuromuscular en pacientes con retropié pronado

    OpenAIRE

    Bersano, Federico

    2012-01-01

    Por medio de una evaluación funcional del retropié, recolectaremos datos sobre su estado desde el punto de vista de la semiología clínica, de la osteocinemática, la artrocinemática y la miocinematica. A partir de aquí se procederá a realizar la aplicación de un Vendaje Neuromuscular para analizar el beneficio de la técnica de corrección articular. Objetivos: Determinar los efectos de la aplicación del vendaje neuromuscular en pacientes con retropié pronado. Sujetos de estudio: Pacientes...

  15. Effect of low-power helium-neon laser irradiation on 13-week immobilized articular cartilage of rabbits.

    Science.gov (United States)

    Bayat, Mohammad; Ansari, Anayatallah; Hekmat, Hossien

    2004-09-01

    Influence of low-power (632.8 nm, Helium-Neon, 13 J/cm2, three times a week) laser on 13-week immobilized articular cartilage was examined with rabbits knee model. Number of chondrocytes and depth of articular cartilage of experimental group were significantly higher than those of sham irradiated group. Surface morphology of sham-irradiated group had rough prominences, fibrillation and lacunae but surface morphology of experimental group had more similarities to control group than to sham irradiated group. There were marked differences between ultrastructure features of control group and experimental group in comparison with sham irradiated group. Low-power Helium-Neon laser irradiation on 13-week immobilized knee joints of rabbits neutrilized adverse effects of immobilization on articular cartilage.

  16. CLINICAL OBSERVATION ON THE THERAPEUTIC EFFECT OF ACUPUNCTURE PLUS MANUAL REPOSITION FOR TREATMENT OF ACUTE LUMBAR VERTEBRAL ARTICULAR DYSKINESIA

    Institute of Scientific and Technical Information of China (English)

    骆钧梵

    2003-01-01

    Objective: To observe the therapeutic effect of acupuncture plus manual reposition for treatment of acute lumbar vertebral articular dyskinesia for choosing a better remedy. Methods: 66 cases of acute lumbar vertebral articular dyskinesia were randomly divided into acupuncture plus manual reposition group (treatment group, n= 33) and routine manual reposition group (control group, n = 33). Yaotong-point was punctured, when, the patient was asked to move his or her waist simultaneously. Results: After one session of treatment, of the two 33 cases in treatment and control groups, 28 (84.85%) and20 (60.61%) were cured, 4 (12.12%) and 9 (27.27%) were improved, and 1 (3.03%) and 4 (12.12%) failed in the treatment. The therapeutic effect of treatment group was significantly superior to that of control group ( P< 0.05). Conclusion: Acupuncture combined with manual reposition is apparently superior to simple routine manual reposition in relieving acute lumbar vertebral articular dyskinesia.

  17. Chondrogenic Differentiation of Human Adipose-Derived Stem Cells: A New Path in Articular Cartilage Defect Management?

    Directory of Open Access Journals (Sweden)

    Jan-Philipp Stromps

    2014-01-01

    Full Text Available According to data published by the Centers for Disease Control and Prevention, over 6 million people undergo a variety of medical procedures for the repair of articular cartilage defects in the U.S. each year. Trauma, tumor, and age-related degeneration can cause major defects in articular cartilage, which has a poor intrinsic capacity for healing. Therefore, there is substantial interest in the development of novel cartilage tissue engineering strategies to restore articular cartilage defects to a normal or prediseased state. Special attention has been paid to the expansion of chondrocytes, which produce and maintain the cartilaginous matrix in healthy cartilage. This review summarizes the current efforts to generate chondrocytes from adipose-derived stem cells (ASCs and provides an outlook on promising future strategies.

  18. Intra-articular synovial sarcoma treated with a transfemoral amputation: a case report and review of the literature.

    Science.gov (United States)

    Gresswell, Steven D; Corsini, Anthony A; Balsamo, Luke H; Miles, Edward F

    2013-08-01

    A case of monophasic intra-articular synovial sarcoma in the right knee of a 39-year-old active duty serviceman treated with a transfemoral amputation is presented. The patient was evaluated for right knee pain and fullness. After further workup, the patient underwent computed tomography guided biopsy, with the tissue specimen consistent with intra-articular synovial sarcoma. The patient elected for a transfemoral amputation rather than limb or joint-sparing surgery. The gross specimen measured 3.5 × 3.0 × 1.7 cm in the posteromedial knee. No metastatic lesions were seen on positron emission tomography-computed tomography. Chemotherapy and radiation therapy have not been utilized. The transfemoral amputation adds to the uniqueness of this report and is discussed with a review of the multimodality treatment toward intra-articular synovial sarcoma in prior published literature.

  19. FIFTH LUMBAR VERTEBRA ASSOCIATED WITH ABSENCE OF SPINOUS PROCESS, LAMINAE AND INFERIOR ARTICULAR PROCESSES. – CASE REPORT

    Directory of Open Access Journals (Sweden)

    Prathap Kumar

    2013-09-01

    Full Text Available Background: The vertebral disorders are the ones which lead to disability and lot of health problems. Since the lumbar part of the vertebral column is the main weight bearing and weight transmitting region, if there is a defective development, the area for muscle attachment and the strong bony structure for the transmission of weight would be missing leading to instability at an early age. In the present case dry and processed fifth lumbar vertebra, of unknown sex which presented the features with absence of spinous process, laminae and the inferior articular processes on both sides which were obtained for teaching the medical undergraduate students in M.S.Ramaiah Medical College, Bangalore. There was absence of spinous process, laminae and the inferior articular processes of fifth lumbar vertebra leading to a wide spina bifida with absence of laminae, inferior articular processes on both sides and spinous process of fifth lumbar vertebra which could be a developmental anomaly.

  20. Assessment of range of motion and muscular shortening in female flamenco dancers. Valoración de las amplitudes articulares y acortamientos musculares en bailaoras de flamenco.

    Directory of Open Access Journals (Sweden)

    José L. Costa Sepúlveda

    2011-12-01

    Full Text Available The purpose of the study was to assess flexibility and range of motion in flamenco dancers of Cádiz, Sevilla and Jaén (Spain through a tests battery. The study population comprised 37 healthy flamenco dancers (25 ± 7,2 years, 1,6 ± 0,5 m y 56 ± 7,6 Kg. They performed a range of flexibility and motion tests (i.e. Kendall test, Nachlas test. Results has shown that there is muscle shortening in most of the tests that flamenco dancers has passed. We conclude that there are not many articles on physiological and fitness aspects of dance and we think that it is necessary a specific physical dancer training, to prevent injuries and to extend dancers life.El objetivo de este estudio es la valoración de la flexibilidad muscular y la amplitud articular en bailaoras de flamenco de la provincia de Cádiz, Sevilla y Jaén, a través de una batería de tests. En el estudio participaron 37 bailaoras de danza flamenca de 25 ± 7,2 años, con una altura con valores de 1,6 ± 0,5 m y 56 ± 7,6 Kg de peso. La batería está compuesta de las siguientes pruebas que se realizarán a través del protocolo de actuación especificado: Prueba de rotadores internos y aductores del hombro, Prueba de Kendall, Prueba de Diagonal Posterior, Prueba de Nachlas, Prueba de Ridge, Prueba de Flexión de cadera con rodilla en extensión, Prueba de Thomas y Prueba de Elongación de los flexores plantares. Los resultados demuestran que existen acortamientos en diferente musculatura implicada como los rotadores internos y aductores del hombro, dorsal ancho, pectoral mayor, redondo mayor, cintura escapular, psoas-ilíaco, recto anterior del muslo y sóleo. Concluir con la escasa existencia de artículos relacionados con la valoración de la condición física de bailarines de cualquier modalidad de danza y con la necesaria aplicación de un entrenamiento planificado complementario con una propuesta de ejercicios de mejora de la musculatura implicada y, así, poder prevenir futuras

  1. Phenotypes of articular disc cells in the rat temporomandibular joint as demonstrated by immunohistochemistry for nestin and GFAP.

    Science.gov (United States)

    Miyako, Hitoshi; Suzuki, Akiko; Nozawa-Inoue, Kayoko; Magara, Jin; Kawano, Yoshiro; Ono, Kazuhiro; Maeda, Takeyasu

    2011-10-01

    The articular disc is a dense collagenous tissue containing disc cells that are phenotypically described as chondrocyte-like cells or fibrochondrocytes. Despite the possible existence of these phenotypes in systemic joints, little is known about the detailed classification of the articular disc cells in the temporomandibular joint. In this immunocytochemical study we examined the localization and distribution patterns of nestin and glial fibrillary acidic protein (GFAP) in the articular disc of the rat temporomandibular joint at postnatal day 1, and weeks 1, 2, 4 and 8, based on the status of tooth eruption and occlusion. Nestin and GFAP are intermediate filament proteins whose expression patterns are closely related to cell differentiation and cell migration. Both types of immunopositive cell greatly increased postnatally to a stable level after postnatal week 4, but they showed different distribution patterns and cell morphologies. Nestin-reactive disc cells, which were characterized by a meagre cytoplasm and thin cytoplasmic processes, were scattered in the articular disc, whereas GFAP-positive cells, characterized by broader processes, existed exclusively in the deeper area. In mature discs, the major proportion of articular disc cells exhibited GFAP immunoreactivity. Furthermore, a double-immunostaining demonstrated that the nestin-negative cells, consisting of GFAP-positive and -negative cells, exhibited immunoreactions for heat shock protein 25. These findings indicate that the articular disc cells comprise at least three types in the rat temporomandibular joint and suggest that their expressions closely relate to mechanical loading forces within the joint, including occlusal force, as observed through postnatal development.

  2. A randomized controlled trial of nonoperative treatment versus open reduction and internal fixation for stable, displaced, partial articular fractures of the radial head: The RAMBO trial

    NARCIS (Netherlands)

    W. Bruinsma (Wendy); I.F. Kodde (Izaäk Frederik); R.-J. De Muinck Keizer (Robert-Jan); P. Kloen (Peter); A. Lindenhovius (Anneluuk); J.P.A.M. Vroemen (Jos); R. Haverlag (Robert); M.P.J. van den Bekerom (Michel); H.W. Bolhuis (Hugo); P. Bullens (Pieter); S.A.G. Meylaerts (Sven); P. van der Zwaal (Peer); E.P. Steller (Erick); G.S. Hageman (Gregory); D. Ring (David); D. den Hartog (Dennis); E.R. Hammacher (Eric); G. King (Graham); G. Athwal (George); K. Faber (Ken); D. Drosdowech (Darren); R. Grewal (Ruby); J.C. Goslings (Carel); N.W.L. Schep (Niels); D. Eygendaal (Denise)

    2014-01-01

    textabstractBackground: The choice between operative or nonoperative treatment is questioned for partial articular fractures of the radial head that have at least 2 millimeters of articular step-off on at least one radiograph (defined as displaced), but less than 2 millimeter of gap between the frag

  3. Efficacy of diagnostic magnetic resonance imaging for articular cartilage lesions of the glenohumeral joint in patients with instability

    Energy Technology Data Exchange (ETDEWEB)

    Hayes, Meredith L.; Collins, Mark S.; Wenger, Doris E. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Morgan, Joseph A.; Dahm, Diane L. [Mayo Clinic, Department of Orthopaedic Surgery, Rochester, MN (United States)

    2010-12-15

    The purpose of this study was primarily to assess the diagnostic performance of magnetic resonance imaging (MRI) in detecting articular cartilage injuries in patients with glenohumeral instability. A secondary purpose was to assess the diagnostic performance of MRI for detection of Hill-Sachs and Bankart lesions. A cohort of 87 consecutive patients who underwent diagnostic MRI and shoulder arthroscopy for instability from 1997 to 2006 were identified. Fifty-five patients (63.2%) underwent MRI with intra-articular contrast medium and 32 patients (36.8%) underwent MRI without contrast medium. MR images were reviewed by two radiologists and interpreted by consensus for the presence of articular cartilage lesions (including Hill-Sachs and Bankart lesions), which were then confirmed by reviewing the operative report and images recorded at arthroscopy. Mean patient age was 27.0 {+-} 10.2 years with a mean clinical and radiographic follow-up of 29 (range 3-72) months. Cartilage injuries were detected arthroscopically in 55 patients (63%). Bankart and Hill-Sachs lesions were identified arthroscopically in 66 patients (75.9%) and 55 patients (63.2%) respectively. The overall sensitivity and specificity for detection of glenohumeral articular cartilage lesions by MRI were 87.2% and 80.6% respectively. The sensitivity and specificity of MRI in detecting Bankart lesions was 98.4% (95% CI 91.9, 99.7) and 95.2% (95% CI 77.3, 99.2) respectively. The sensitivity and specificity of MRI in detecting Hill-Sachs lesions was 96.3% (95% CI 87.6, 98.9%) and 90.6% (95% CI 75.7, 96.9) respectively. No statistically significant difference was found between MRI examinations with and without intra-articular gadolinium (p = 0.89). Magnetic resonance imaging demonstrates high sensitivity and specificity for the diagnosis of articular cartilage injuries in patients with glenohumeral instability. MRI with or without intra-articular contrast medium in this study were equally reliable as a non

  4. Intra-articular fibroma of tendon sheath in a knee joint associated with iliotibial band friction syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Dong Ho; Choi, Sun Seob; Kim, Soo Jin; Lih, Wang [Dong-A University Medical Center, Busan (Korea, Republic of)

    2015-02-15

    Iliotibial band (ITB) friction syndrome is a common overuse injury typically seen in the active athlete population. A nodular lesion on the inner side of the ITB as an etiology or an accompanying lesion from friction syndrome has been rarely reported. A 45-year-old male presented with recurrent pain and a movable nodule at the lateral joint area, diagnosed as ITB friction syndrome. The nodule was confirmed as a rare intra-articular fibroma of the tendon sheath (FTS) on the basis of histopathologic findings. We describe the MRI findings, arthroscopic and pathologic features, in this case of intra-articular FTS presenting with ITB friction syndrome.

  5. Intra-articular fibroma of tendon sheath in a knee joint associated with iliotibial band friction syndrome.

    Science.gov (United States)

    Ha, Dong-Ho; Choi, Sunseob; Kim, Soo-Jin; Lih, Wang

    2015-01-01

    Iliotibial band (ITB) friction syndrome is a common overuse injury typically seen in the active athlete population. A nodular lesion on the inner side of the ITB as an etiology or an accompanying lesion from friction syndrome has been rarely reported. A 45-year-old male presented with recurrent pain and a movable nodule at the lateral joint area, diagnosed as ITB friction syndrome. The nodule was confirmed as a rare intra-articular fibroma of the tendon sheath (FTS) on the basis of histopathologic findings. We describe the MRI findings, arthroscopic and pathologic features, in this case of intra-articular FTS presenting with ITB friction syndrome.

  6. Horizontal intra-articular patellar dislocation resulting in quadriceps avulsion and medial patellofemoral ligament tear: a case report.

    Science.gov (United States)

    Kramer, Dennis E; Simoni, Michael K

    2013-07-01

    Intra-articular patellar dislocations are rare. We present a 13-year-old boy who sustained a complete horizontal intra-articular patellar dislocation following blunt trauma to the flexed knee. Closed reduction was unsuccessful and open reduction indicated a repairable quadriceps avulsion and medial patellofemoral ligament tear. He is the youngest patient to sustain a quadriceps rupture and the only patient to sustain a medial patellofemoral ligament tear to date. His flexed knee and the horizontally positioned patella (seen on lateral radiograph) were indicative of a complete rotational injury with extensor mechanism involvement. Open reduction allowed for the repair of both injuries and a favorable outcome.

  7. Quantitative ultrasound imaging detects degenerative changes in articular cartilage surface and subchondral bone

    Science.gov (United States)

    Saarakkala, Simo; Laasanen, Mikko S.; Jurvelin, Jukka S.; Töyräs, Juha

    2006-10-01

    Previous studies have suggested that quantitative ultrasound imaging could sensitively diagnose degeneration of the articular surface and changes in the subchondral bone during the development of osteoarthrosis (OA). We have recently introduced a new parameter, ultrasound roughness index (URI), for the quantification of cartilage surface roughness, and successfully tested it with normal and experimentally degraded articular surfaces. In this in vitro study, the applicability of URI was tested in bovine cartilage samples with spontaneously developed tissue degeneration. Simultaneously, we studied the sensitivity of quantitative ultrasound imaging to detect degenerative changes in the cartilage-bone interface. For reference, histological degenerative grade of the cartilage samples was determined. Mechanical reference measurements were also conducted. Cartilage surface roughness (URI) was significantly (p < 0.05) higher in histologically degenerated samples with inferior mechanical properties. Ultrasound reflection at the cartilage-bone interface was also significantly (p < 0.05) increased in degenerated samples. Furthermore, it was quantitatively confirmed that ultrasound attenuation in the overlying cartilage significantly affects the measured ultrasound reflection values from the cartilage-bone interface. To conclude, the combined ultrasound measurement of the cartilage surface roughness and ultrasound reflection at the cartilage-bone interface complement each other, and may together enable more sensitive and quantitative diagnosis of early OA or follow up after surgical cartilage repair.

  8. Quantitative ultrasound imaging detects degenerative changes in articular cartilage surface and subchondral bone

    Energy Technology Data Exchange (ETDEWEB)

    Saarakkala, Simo [Department of Nuclear Medicine, Etelae-Savo Hospital District, Mikkeli Central Hospital, Porrassalmenkatu 35-37, 50100 Mikkeli (Finland); Laasanen, Mikko S [Information Technology R and D Unit, Engineering Kuopio, Savonia Polytechnic, POB 1188, FIN-70211 Kuopio (Finland); Jurvelin, Jukka S [Department of Physics, University of Kuopio, POB 1627, FIN-70211 Kuopio (Finland); Toeyraes, Juha [Department of Clinical Neurophysiology, Kuopio University Hospital and University of Kuopio, POB 1777, FIN-70211 Kuopio (Finland)

    2006-10-21

    Previous studies have suggested that quantitative ultrasound imaging could sensitively diagnose degeneration of the articular surface and changes in the subchondral bone during the development of osteoarthrosis (OA). We have recently introduced a new parameter, ultrasound roughness index (URI), for the quantification of cartilage surface roughness, and successfully tested it with normal and experimentally degraded articular surfaces. In this in vitro study, the applicability of URI was tested in bovine cartilage samples with spontaneously developed tissue degeneration. Simultaneously, we studied the sensitivity of quantitative ultrasound imaging to detect degenerative changes in the cartilage-bone interface. For reference, histological degenerative grade of the cartilage samples was determined. Mechanical reference measurements were also conducted. Cartilage surface roughness (URI) was significantly (p < 0.05) higher in histologically degenerated samples with inferior mechanical properties. Ultrasound reflection at the cartilage-bone interface was also significantly (p < 0.05) increased in degenerated samples. Furthermore, it was quantitatively confirmed that ultrasound attenuation in the overlying cartilage significantly affects the measured ultrasound reflection values from the cartilage-bone interface. To conclude, the combined ultrasound measurement of the cartilage surface roughness and ultrasound reflection at the cartilage-bone interface complement each other, and may together enable more sensitive and quantitative diagnosis of early OA or follow up after surgical cartilage repair.

  9. Condensed cellular seeded collagen gel as an improved biomaterial for tissue engineering of articular cartilage.

    Science.gov (United States)

    Mueller-Rath, Ralf; Gavénis, Karsten; Andereya, Stefan; Mumme, Torsten; Albrand, Monique; Stoffel, Marcus; Weichert, Dieter; Schneider, Ulrich

    2010-01-01

    Three-dimensional autologous chondrocyte implantation based on collagen gel as matrix scaffold has become a clinically applied treatment for focal defects of articular cartilage. However, the low biomechanical properties of collagen gel makes intraoperative handling difficult and creates the risk of early damages to the vulnerable implant. The aim of the study was to create a stabilized form of collagen gel and to evaluate its biomechanical and biochemical properties.Collagen type-I gel was seeded with human articular chondrocytes. 20 samples were subject to condensation which was achieved mechanically by compression and filtration. Control samples were left uncondensed. From both types of gels 10 samples were used for initial biomechanical evaluation by means of unconfined compression and 10 samples were cultivated under standard conditions in vitro. Following cultivation the samples were evaluated by conventional histology and immunohistochemistry. The proliferation rate was calculated and matrix gene expression was quantified by real-time PCR.The biomechanical tests revealed a higher force carrying capacity of the condensed specimens. Strain rate dependency and relaxation was seen in both types of collagen gel representing viscoelastic material properties. Cells embedded within the condensed collagen gel were able to produce extracellular matrix proteins and showed proliferation.Condensed collagen gel represents a mechanically improved type of biomaterial which is suitable for three-dimensional autologous chondrocyte implantation.

  10. Study on the Microstructure of Human Articular Cartilage/Bone Interface

    Institute of Scientific and Technical Information of China (English)

    Yaxiong Liu; Qin Lian; Jiankang He; Jinna Zhao; Zhongmin Jin; Dichen Li

    2011-01-01

    For improving the theory of gradient microstructure of cartilage/bone interface, human distal femurs were studied. Scanning Electron Microscope (SEM), histological sections and MicroCT were used to observe, measure and model the microstructure of cartilage/bone interface. The results showed that the cartilage/bone interface is in a hierarchical structure which is composed of four different tissue layers. The interlocking of hyaline cartilage and calcified cartilage and that of calcified cartilage and subchondral bone are in the manner of"protrusion-pore" with average diameter of 17.0 μm and 34.1 μm respectively. In addition, the cancellous bone under the cartilage is also formed by four layer hierarchical structure, and the adjacent layers are connected by bone trabecula in the shape of H, I and Y, forming a complex interwoven network structure. Finally, the simplified structure model of the cartilage/bone interface was proposed according to the natural articular cartilage/bone interface. The simplified model is a 4-layer gradient biomimetic structure, which corresponds to four different tissues of natural cartilage/bone interface. The results of this work would be beneficial to the design of bionic scaffold for the tissue engineering of articular cartilage/bone.

  11. In-laboratory diffraction-enhanced X-ray imaging for articular cartilage.

    Science.gov (United States)

    Muehleman, Carol; Fogarty, Daniel; Reinhart, Benjamin; Tzvetkov, Tochko; Li, Jun; Nesch, Ivan

    2010-07-01

    The loss of articular cartilage characteristic of osteoarthritis can only be diagnosed by joint space narrowing when conventional radiography is used. This is due to the lack of X-ray contrast of soft tissues. Whereas conventional radiography harnesses the X-ray attenuation properties of tissues, Diffraction Enhanced Imaging (DEI), a novel radiographic technique, allows the visualization of soft tissues simultaneous with calcified tissues by virtue of its ability to not only harness X-ray attenuation but also the X-ray refraction from tissue boundaries. Previously, DEI was dependent upon synchrotron X-rays, but more recently, the development of nonsynchrotron DEI units has been explored. These developments serve to elaborate the full potential of radiography. Here, we tested the potential of an in-laboratory DEI system, called Diffraction-Enhanced X-ray Imaging (DEXI), to render images of articular cartilage displaying varying degrees of degradation, ex vivo. DEXI allowed visualization of even early stages of cartilage degeneration such as surface fibrillation. This may be of eventual clinical significance for the diagnosis of early stages of degeneration, or at the very least, to visualize soft tissue degeneration simultaneous with bone changes.

  12. Poly(dopamine) coating of scaffolds for articular cartilage tissue engineering.

    Science.gov (United States)

    Tsai, Wei-Bor; Chen, Wen-Tung; Chien, Hsiu-Wen; Kuo, Wei-Hsuan; Wang, Meng-Jiy

    2011-12-01

    A surface modification technique based on poly(dopamine) deposition developed from oxidative polymerization of dopamine is known to promote cell adhesion to several cell-resistant substrates. In this study this technique was applied to articular cartilage tissue engineering. The adhesion and proliferation of rabbit chondrocytes were evaluated on poly(dopamine)-coated polymer films, such as polycaprolactone, poly(L-lactide), poly(lactic-co-glycolic acid) and polyurethane, biodegradable polymers that are commonly used in tissue engineering. Cell adhesion was significantly increased by merely 15 s of dopamine incubation, and 4 min incubation was enough to reach maximal cell adhesion, a 1.35-2.69-fold increase compared with that on the untreated substrates. Cells also grew much faster on the poly(dopamine)-coated substrates than on untreated substrates. The increase in cell affinity for poly(dopamine)-coated substrates was demonstrated via enhancement of the immobilization of serum adhesive proteins such as fibronectin. When the poly(dopamine)-coating technique was applied to three-dimensional (3-D) polyurethane scaffolds, the proliferation of chondrocytes and the secretion of glycosaminoglycans were increased compared with untreated scaffolds. Our results show that the deposition of a poly(dopamine) layer on 3-D porous scaffolds is a simple and promising strategy for articular cartilage tissue engineering, and may be applied to other types of tissue engineering.

  13. A comparison of healthy human and swine articular cartilage dynamic indentation mechanics.

    Science.gov (United States)

    Ronken, S; Arnold, M P; Ardura García, H; Jeger, A; Daniels, A U; Wirz, D

    2012-05-01

    Articular cartilage is a multicomponent, poroviscoelastic tissue with nonlinear mechanical properties vital to its function. A consequent goal of repair or replacement of injured cartilage is to achieve mechanical properties in the repair tissue similar to healthy native cartilage. Since fresh healthy human articular cartilage (HC) is not readily available, we tested whether swine cartilage (SC) could serve as a suitable substitute for mechanical comparisons. To a first approximation, cartilage tissue and surgical substitutes can be evaluated mechanically as viscoelastic materials. Stiffness measurements (dynamic modulus, loss angle) are vital to function and are also a non-destructive means of evaluation. Since viscoelastic material stiffness is strongly strain rate dependent, stiffness was tested under different loading conditions related to function. Stiffness of healthy HC and SC specimens was determined and compared using two non-destructive, mm-scale indentation test modes: fast impact and slow sinusoidal deformation. Deformation resistance (dynamic modulus) and energy handling (loss angle) were determined. For equivalent anatomic locations, there was no difference in dynamic modulus. However, the HC loss angle was ~35% lower in fast impact and ~12% higher in slow sinusoidal mode. Differences seem attributable to age (young SC, older HC) but also to species anatomy and biology. Test mode-related differences in human-swine loss angle support use of multiple function-related test modes. Keeping loss angle differences in mind, swine specimens could serve as a standard of comparison for mechanical evaluation of e.g. engineered cartilage or synthetic repair materials.

  14. Mechanical vibrations increase the proliferation of articular chondrocytes in high-density culture.

    Science.gov (United States)

    Kaupp, J A; Waldman, S D

    2008-07-01

    Tissue engineering is a promising approach for articular cartilage repair; however, it still has proven a challenge to produce tissue from the limited number of cells that can be extracted from a single individual. Relatively few cell expansion methods exist without the problems of dedifferentiation and/or loss of potency. Previously, it has been shown that mechanical vibrations can enhance chondrocyte proliferation in monolayer culture. Thus, it was hypothesized that chondrocytes grown in high-density culture would respond in a similar fashion while maintaining phenotypic stability. Isolated bovine articular chondrocytes were seeded in high-density culture on Millicell filters and subjected to mechanical vibrations 48 h after seeding. Mechanical vibrations enhanced chondrocyte proliferation at frequencies above 350 Hz, with the peak response occurring at a 1g amplitude for a duration of 30 min. Under these conditions, the gene expression of cartilage-specific and dedifferentiation markers (collagen II, collagen I, and aggrecan) were unchanged by the imposed stimulus. To determine the effect of accumulated extracellular matrix (ECM) on this proliferative response, selected cultures were stimulated under the same conditions after varying lengths of preculture. The amount of accumulated ECM (collagen and proteoglycans) decreased this proliferative response, with the cultures becoming insensitive to the stimulus after 1 week of preculture. Thus, mechanical vibration can serve as an effective means preferentially to stimulate the proliferation of chondrocytes during culture, but its effects appear to be limited to the early stages where ECM accumulation is at a minimum.

  15. Wear and damage of articular cartilage with friction against orthopedic implant materials.

    Science.gov (United States)

    Oungoulian, Sevan R; Durney, Krista M; Jones, Brian K; Ahmad, Christopher S; Hung, Clark T; Ateshian, Gerard A

    2015-07-16

    The objective of this study was to measure the wear response of immature bovine articular cartilage tested against glass or alloys used in hemiarthroplasties. Two cobalt chromium alloys and a stainless steel alloy were selected for these investigations. The surface roughness of one of the cobalt chromium alloys was also varied within the range considered acceptable by regulatory agencies. Cartilage disks were tested in a configuration that promoted loss of interstitial fluid pressurization to accelerate conditions believed to occur in hemiarthroplasties. Results showed that considerably more damage occurred in cartilage samples tested against stainless steel (10 nm roughness) and low carbon cobalt chromium alloy (27 nm roughness) compared to glass (10 nm) and smoother low or high carbon cobalt chromium (10 nm). The two materials producing the greatest damage also exhibited higher equilibrium friction coefficients. Cartilage damage occurred primarily in the form of delamination at the interface between the superficial tangential zone and the transitional middle zone, with much less evidence of abrasive wear at the articular surface. These results suggest that cartilage damage from frictional loading occurs as a result of subsurface fatigue failure leading to the delamination. Surface chemistry and surface roughness of implant materials can have a significant influence on tissue damage, even when using materials and roughness values that satisfy regulatory requirements.

  16. Incomplete restoration of immobilization induced softening of young beagle knee articular cartilage after 50-week remobilization.

    Science.gov (United States)

    Haapala, J; Arokoski, J; Pirttimäki, J; Lyyra, T; Jurvelin, J; Tammi, M; Helminen, H J; Kiviranta, I

    2000-01-01

    The aim of this study was to characterize the biomechanical and structural changes in canine knee cartilage after an initial 11-week immobilization and subsequent remobilization period of 50 weeks. Cartilage from the immobilized and remobilized knee was compared with the tissue from age-matched control animals. Compressive stiffness, in the form of instant shear modulus (ISM) and equilibrium shear modulus (ESM) of articular cartilage, was investigated using an in situ indentation creep technique. The local variations in cartilage of glycosaminoglycan (GAG) concentration were measured with a microspectrophotometer after safranin O staining of histological sections. Using a computer-based quantitative polarized light microscopy method, collagen-related optical retardation, gamma, of cartilage zones were performed to investigate the collagen network of cartilage. Macroscopically, cartilage surfaces of the knee joint remained intact both after immobilization and remobilization periods. Immobilization caused significant softening of the lateral femoral and tibial cartilages, as expressed by ESM (up to 30%, p test points. The changes of ESM were positively correlated with the alterations in GAG content of the superficial and deep zones after immobilization and remobilization. This confirms the key role of protoglycans in the regulation of the equilibrium stiffness of articular cartilage. As a conclusion, immobilization of the joint of a young individual may cause long-term, if not permanent, alterations of cartilage biomechanical properties. This may predispose joint to degenerative changes later in life.

  17. Role of articular disc in cartilaginous growth of the mandible in rats

    Directory of Open Access Journals (Sweden)

    Fang Xiao

    2017-01-01

    Full Text Available Displacement of the temporomandibular joint (TMJ disc causes a lateral shift of the mandible and less-developed and/or distally located mandible unilaterally and bilaterally, respectively, if occurred in growing individuals. The purpose of this study was to evaluate mandibular condylar growth in growing rats after TMJ discectomy and to explore a certain significant role of articular disc in the TMJ in mandibular or cartilaginous growth. Eighteen 4-week-old Wistar strain male rats were divided into two groups with nine in each group, i.e., rats with TMJ discectomy (discectomy group and only sham operation (control group. Four weeks after initiating the experiment, morphometric analyses of the mandible were performed using a rat and mouse cephalometer and micro-computed tomography. Then, the mandibular condyles were subjected to histomorphometric analyses. Condylar and mandibular growth was reduced significantly in the discectomy group than in the control group. In the discectomy group, the condyle also became flatter and smaller. In addition, the 4-layer structure of condylar cartilage was unclear with thicker fibrous and thinner lower hypertrophic layers in the discectomy group when compared to the controls. It is shown that resection of the articular disc substantially affects condylar and mandibular growth in terms of the cartilaginous growth, suggesting that TMJ disc is indispensable for maintaining normal growth of the condyle and mandible, leading to optimal development of the TMJ and the entire mandible.

  18. Deginerative changes of femoral articular cartilage in the knee : comparative study of specimen sonography and pathology

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ju Youn; Hong, Sung Hwan; Sohn, Jin Hee; Wee, Young Hoon; Chang, Jun Dong; Park, Hong Seok; Lee, Eil Seoung; Kang Ik Won [Hallym Univ. College of Medicine, Seoul (Korea, Republic of)

    2001-04-01

    To determine the sonographic findings of degenerative change in femoral articular cartilage of the knee by comparative study of specimen sonography and pathology. We obtained 40 specimens of cartilage of the femur (20 medial and 20 lateral condylar) from 20 patients with osteoarthritis of the knee who had undergone total knee replacement. The specimens were placed in a saline-filled container and sonography was performed using a 10-MHz linear transducer. Sonographic abnormalities were evaluated at the cartilage surface, within the cartilage, and at the bone-cartilage interface, and were compared with the corresponding pathologic findings. In addition, cartilage thickness was measured at a representative portion of each femoral cartilage specimen and was compared with the thickness determined by sonography. 'Dot' lesions, irregularity or loss of the hyperechoic line, were demonstrated by sonography at the saline-cartilage interface of 14 cartilages. Pathologic examination showed that these findings corresponded to cleft, detachment, erosion, and degeneration. Irregularities in the hyperechoic line at the bone-cartilage interface were revealed by sonography in eight cartilages and were related to irregularity or loss of tidemark, downward displacement of the cartilage, and subchondral callus formation. Dot lesions, corresponding to cleft and degeneration, were noted within one cartilage. Cartilage thickness measured on specimen and by sonography showed no significant difference (p=0.446). Specimen sonography suggested that articular cartilage underwent degenerative histopathological change. Cartilage thickness measured by sonography exactly reflected real thickness.

  19. Stem cells and other innovative intra-articular therapies for osteoarthritis: what does the future hold?

    Directory of Open Access Journals (Sweden)

    Singh Jasvinder A

    2012-05-01

    Full Text Available Abstract Osteoarthritis (OA, the most common type of arthritis in the world, is associated with suffering due to pain, productivity loss, decreased mobility and quality of life. Systemic therapies available for OA are mostly symptom modifying and have potential gastrointestinal, renal, hepatic, and cardiac side effects. BMC Musculoskeletal Disorders recently published a study showing evidence of reparative effects demonstrated by homing of intra-articularly injected autologous bone marrow stem cells in damaged cartilage in an animal model of OA, along with clinical and radiographic benefit. This finding adds to the growing literature showing the potential benefit of intra-articular (IA bone marrow stem cells. Other emerging potential IA therapies include IL-1 receptor antagonists, conditioned autologous serum, botulinum toxin, and bone morphogenetic protein-7. For each of these therapies, trial data in humans have been published, but more studies are needed to establish that they are safe and effective. Several additional promising new OA treatments are on the horizon, but challenges remain to finding safe and effective local and systemic therapies for OA. Please see related article: http://www.biomedcentral.com/1471-2474/12/259

  20. Treatment of unstable extra-articular distal radius fractures by modified intrafocal Kapandji method.

    Science.gov (United States)

    Ruschel, Paulo Henrique; Albertoni, Walter Manna

    2005-03-01

    The authors prospectively assess the results of surgically treated, unstable extra-articular distal radius fractures from 29 patients with good bone quality. Mean age was 49 years, ranging from 22 to 69 years; the female gender was the most frequently affected (58.6% of the cases). Surgical fixation was indicated for fractures presenting an angulation above 20 degrees , marked dorsal comminution, and radius shortening in excess of 10 mm on initial x-rays (anteroposterior and lateral views). The Kapandji technique, with intrafocal, nonthreaded Kirschner wires, was employed. Clinical data assessed anatomic aspects according to Scheck, functional aspect after Gartland and Werley, strength by Scheck's methods, and esthetic by Frykman's criteria. Functional assessment, according to Gartland and Werley, revealed 72.1% of excellent and good results at 3 months; 89.7% at 6 months; and 96.6% at 12 months. Immediate postoperative reduction was not maintained at the final follow-up at 12 months; however, that loss was not severe, and the anatomic outcome was good and excellent in 96.6% of the cases. Six patients presented complications. Four patients presented reflex sympathetic dystrophy; 1 patient had a superficial Kirschner wire infection, and another patient had radial nerve superficial branch paresthesia. The employed technique showed to be effective in the treatment of unstable, extra-articular fractures of the distal radius. It is easy to learn and to perform. The device employed has a low cost and is widely available in operation rooms.