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Sample records for articular inflamatoria del

  1. Abordaje psicológico del paciente con enfermedad inflamatoria intestinal

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    Amo Mateos, Beatriz del

    2015-01-01

    La enfermedad inflamatoria intestinal es un término en el que se engloban dos trastornos, colitis ulcerosa y enfermedad de Crohn, que se caracterizan por una inflamación crónica del tubo digestivo y que cursan con periodos de exacerbaciones y recidivas. Su incidencia ha aumentado mucho en las últimas décadas sobre todo en países desarrollados, y el pico máximo de diagnóstico se encuentra entre los 20 y los 35 años. Estos pacientes además de todos los síntomas físicos producidos por la enferme...

  2. Estudio del metabolismo mineral y óseo en pacientes pediátricos afectos de enfermedad inflamatoria intestinal

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    Aguilar Quintero, María

    2014-01-01

    INTRODUCCIÓN Y MOTIVACIÓN DE LA TESIS En los últimos años ha aumentado el interés por conocer las alteraciones del metabolismo osteomineral en los pacientes afectos de enfermedad inflamatoria intestinal (EII), debido entre otras razones a que un gran número estos pacientes presentan una enfermedad metabólica ósea como epifenómeno de su proceso de base. Así, se estima que la prevalencia de EII subyacente estaría en torno al 40-50% en caso de osteopenia y al 5 al 30% en caso de o...

  3. Valor del estudio celular del esputo en el seguimiento de las enfermedades inflamatorias de la vía aérea

    OpenAIRE

    2012-01-01

    El análisis celular del esputo, espontáneo u obtenido mediante la técnica de esputo inducido, se ha transformado en una herramienta ampliamente difundida para la evaluación y orientación del tratamiento de las enfermedades inflamatorias de la vía aérea, principalmente asma, enfermedad pulmonar obstructiva crónica y bronquitis eosinofílica. Se han aportado evidencias sobre la utilidad de la técnica del esputo inducido, validada y estandarizada, para ser empleada en pacientes con dificultades p...

  4. Estudio de la respuesta inflamatoria del ácido poliláctico

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    Josa, Célia

    2011-01-01

    Doble titulació El ácido poliláctico (PLA) es un polímero biodegradable ampliamente utilizado en la fabricación de dispositivos médicos y más recientemente en la fabricación de andamios para ingeniería de tejidos. Una de las respuestas desencadenadas al implantar un biomaterial en el cuerpo es la respuesta inmune. Esta puede conllevar a su vez a la respuesta inflamatoria que es llevada a cabo principalmente por monocitos que posteriormente se transforman en macrófagos. Los macr...

  5. Pharmacological Nutrition in Inflammatory Bowel Diseases Nutrición farmacológica en las enfermedades inflamatorias del instestino

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    F. G. Campos

    2003-04-01

    Full Text Available Inflammatory Bowel Diseases - ulcerative colitis and Crohn’s disease- are chronic gastrointestinal inflammatory diseases of unknown etiology. Decreased oral intake, malabsorption, accelerated nutrient losses, increased requirements, and drug-nutrient interactions cause nutritional and functional deficiencies that require proper correction by nutritional therapy. The goals of the different forms of nutritional therapy are to correct nutritional disturbances and to modulate inflammatory response, thus influencing disease activity. Nutritional intervention may improve outcome in certain individuals; however, because of the costs and complications of such therapy, careful selection is warranted. Total parenteral nutrition has been used to correct and prevent nutritional disturbances and to promote bowel rest during active disease, mainly in cases of digestive fistulae with a high output. Its use should be reserved for patients who cannot tolerate enteral nutrition. Enteral nutrition is effective in inducing clinical remission of disease in adults and promoting growth in children. Recent research has focused on the use of specific nutrients as primary treatment agents. Although some reports have indicated that glutamine, short-chain fatty acids, antioxidants and immunonutrition with omega-3 fatty acids are an important therapeutic alternative in the management of inflammatory bowel diseases, the beneficial reported effects have yet to be translated into the clinical practice. The real efficacy of these nutrients still need further evaluation through prospective and randomized trials.Las enfermedades inflamatorias del intestino -colitis ulcerosa y enfermedad de Crohn- son enfermedades crónicas de causa desconocida. La disminución de la ingesta, la malabsorción, la pérdida acelerada de nutrientes, el aumento de los requerimientos y las interacciones entre medicamentos y nutrientes determinan carencias nutricionales y funcionales que obligan a una

  6. Rescate articular con colgajo anterolateral del muslo

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    F.J. García-Bernal

    2015-06-01

    Full Text Available La preservación del nivel de amputación tanto de la extremidad superior como de la inferior, puede mejorar la función residual y el proceso de rehabilitación protésica de la misma. Ambas van a estar condicionadas por la longitud restante de la extremidad, la presencia o no de articulaciones operativas y la calidad de la cobertura del muñón. Presentamos 2 casos de amputaciones. El primero es un caso agudo de amputación traumática de extremidad superior a la altura del tercio proximal de antebrazo, que asocia avulsión cutánea circular desde el tercio medio del brazo y con articulación de codo conservada. El segundo, es la secuela de una amputación infracondílea de extremidad inferior por osteosarcoma que presenta fístulas cutáneas con drenaje supurativo por osteomielitis en el muñón tibial. En ambos pacientes realizamos cobertura con colgajo anterolateral de muslo anastomosado a la arteria radial en el caso de la extremidad superior, y a la arteria genicular descendente en la extremidad inferior. En los dos casos el postoperatorio transcurrió sin complicaciones, logrando preservar las articulaciones del codo y de la rodilla respectivamente, así como la posterior rehabilitación protésica. Consideramos que el colgajo anterolateral del muslo permite aportar tejido de buena calidad como cobertura del muñón de amputación. Dadas las características del tejido aportado y su volumen, es idóneo tanto para cobertura de defectos agudos como de déficits de almohadillado en casos crónicos.

  7. Valor del estudio celular del esputo en el seguimiento de las enfermedades inflamatorias de la vía aérea

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    Juan Antonio Mazzei

    2012-08-01

    Full Text Available El análisis celular del esputo, espontáneo u obtenido mediante la técnica de esputo inducido, se ha transformado en una herramienta ampliamente difundida para la evaluación y orientación del tratamiento de las enfermedades inflamatorias de la vía aérea, principalmente asma, enfermedad pulmonar obstructiva crónica y bronquitis eosinofílica. Se han aportado evidencias sobre la utilidad de la técnica del esputo inducido, validada y estandarizada, para ser empleada en pacientes con dificultades para expectorar. Numerosas investigaciones dieron cuenta de la efectividad de basar las decisiones terapéuticas en el componente inflamatorio de la vía aérea mediante el recuento de células en el esputo. Varios estudios mostraron que, en pacientes con asma el análisis celular de esputo guía en la determinación de estrategias para disminuir las exacerbaciones y para mejorar la función pulmonar, aun en pacientes con asma grave, para disminuir el remodelamiento; también se ha descrito su utilidad en pacientes con EPOC, para la disminución de las exacerbaciones.

  8. Valor del estudio celular del esputo en el seguimiento de las enfermedades inflamatorias de la vía aérea Value of sputum analysis in the management of inflammatory airway diseases

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    Juan Antonio Mazzei; Adriana E. Rocher; Luis Palaoro

    2012-01-01

    El análisis celular del esputo, espontáneo u obtenido mediante la técnica de esputo inducido, se ha transformado en una herramienta ampliamente difundida para la evaluación y orientación del tratamiento de las enfermedades inflamatorias de la vía aérea, principalmente asma, enfermedad pulmonar obstructiva crónica y bronquitis eosinofílica. Se han aportado evidencias sobre la utilidad de la técnica del esputo inducido, validada y estandarizada, para ser empleada en pacientes con dificultades p...

  9. Tratamiento no protésico de las lesiones del cartílago articular

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    Carranza Bencano, A.

    1997-01-01

    Las alteraciones del cartílago articular constituyen un gran reto planteado a la Cirugía Ortopédica actual, por el aumento de traumatismos articulares y ante el incremento del porvenir de la vida de la población con el consiguiente envejecimiento del aparato locomotor y el desarrollo de artrosis degenerativas. Los éxitos de las prótesis articulares quedan ensombrecidos por su porvenir incierto en largos períodos de seguimiento. Por ello, en este artículo se revisa la situación actual de los m...

  10. Elaboración y validación de un cuestionario reducido de la versión española del cuestionario de calidad de vida específico para la enfermedad inflamatoria intestinal

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    Alcalá Escriche, María José

    2003-01-01

    Los cuestionarios de medida de calidad de vida en la enfermedad inflamatoria intestinal (EII), están constituidos habitualmente por un gran número de preguntas precisando tiempo para su cumplimentación y posterior análisis, lo que dificulta su utilización en la práctica clínica. El objetivo del trabajo de investigación es la elaboración y posterior validación, de un cuestionario reducido de la versión española del ¨Inflammatory Bowel Disease Questionnaire¨, Cuestionario de Calidad de Vida en ...

  11. Enfermedad inflamatoria crónica intestinal canina: hallazgos endoscópicos, bioquímicos y anatomopatológicos del tracto gastrointestinal anterior

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    R Crespo

    2015-01-01

    Full Text Available Se ha realizado un estudio retrospectivo a 26 perros, machos y hembras, que acudieron al Servicio de Medicina Interna (Unidad de Endoscopia del Hospital Clínico Veterinario de la Facultad de Veterinaria de la Universidad de Murcia (España, a los que se les diagnosticó enfermedad inflamatoria crónica intestinal del tracto gastrointestinal anterior. Los casos se eligieron en función del diagnóstico clínico, endoscópico y anatomopatológico realizado, con el objetivo de evaluar potenciales correlaciones entre estos parámetros. La disminución de proteínas totales y la albúmina no fue estadísticamente significativa en relación con el grado de inflamación de la mucosa gastrointestinal, no obstante, los animales que presentaban un infiltrado de tipo linfoplasmocitario tenían tendencia a la pérdida de albúmina. Se encontró una correlación estadísticamente significativa (P < 0,05 entre el tipo de infiltrado y la presencia de congestión en la mucosa de estómago y duodeno. Una mayor congestión a estos niveles se corresponde con el infiltrado linfoplasmocitario. También se obtuvo un resultado que, a pesar de no ser estadísticamente significativo, sí se aproxima a la significación estadística (P < 0,1 entre el grado de congestión y la intensidad del infiltrado, ya que un grado de congestión mayor de la mucosa se corresponde con una mayor intensidad de infiltrado linfoplasmocitario, tanto a nivel gástrico como duodenal. Además se vio que la friabilidad está asociada a inflamación en duodeno, y los animales que no tenían un correcto cierre del cardias presentaban esofagitis por reflujo.

  12. Tratamiento de los defectos del cartílago articular en la rodilla

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    Reverté Vinaixa, María Mercedes

    2015-01-01

    Las lesiones condrales y osteocondrales en la rodilla aparecen en gente joven, activa y con gran expectativa de vida. Estás suponen un gran problema, puesto que este una vez destruido, ya no se repara. Debido a la escasa capacidad intrínseca de curación del cartílago, sus lesiones tienden a causar morbilidad en forma de dolor articular y disfunción. Existen diferentes técnicas quirúrgicas que mejoran la sintomatología y la historia natural de las lesiones condrales. Las lesiones del cartílago...

  13. Valor pronóstico de la expresión de las metaloproteinasas y de sus inhibidores tisulares en células inflamatorias del estroma peritumoral estudiada mediante micromatices tisulares en piezas de prostatectomía radical

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    Rodríguez Corcos, Ángel

    2015-01-01

    Introducción: Hay nuevas evidencias que la inflamación prostática puede contribuir al carcinoma de próstata. La gran mayoría de las muestras quirúrgicas de tejido prostático muestran alguna evidencia de inflamación prostática. La identificación de un fenotipo de células mononucleares inflamatorias asociadas con el riesgo de cáncer de próstata y/o comportamiento agresivo del tumor puede ser de un gran interés, nos permitiría identificar a hombres en riesgo de desarrollar cáncer de próstata que...

  14. Valor del estudio celular del esputo en el seguimiento de las enfermedades inflamatorias de la vía aérea Value of sputum analysis in the management of inflammatory airway diseases

    Directory of Open Access Journals (Sweden)

    Juan Antonio Mazzei

    2012-08-01

    Full Text Available El análisis celular del esputo, espontáneo u obtenido mediante la técnica de esputo inducido, se ha transformado en una herramienta ampliamente difundida para la evaluación y orientación del tratamiento de las enfermedades inflamatorias de la vía aérea, principalmente asma, enfermedad pulmonar obstructiva crónica y bronquitis eosinofílica. Se han aportado evidencias sobre la utilidad de la técnica del esputo inducido, validada y estandarizada, para ser empleada en pacientes con dificultades para expectorar. Numerosas investigaciones dieron cuenta de la efectividad de basar las decisiones terapéuticas en el componente inflamatorio de la vía aérea mediante el recuento de células en el esputo. Varios estudios mostraron que, en pacientes con asma el análisis celular de esputo guía en la determinación de estrategias para disminuir las exacerbaciones y para mejorar la función pulmonar, aun en pacientes con asma grave, para disminuir el remodelamiento; también se ha descrito su utilidad en pacientes con EPOC, para la disminución de las exacerbaciones.Cellular analysis of sputum either spontaneous or by induced sputum technique, has become a widespread tool for the evaluation and guidance of treatment of inflammatory diseases of the airway, primarily asthma, COPD and eosinophilic bronchitis. Induced sputum method is a validated, standardized and non-invasive technique, useful in patients with difficulties to expectorate. Its implementation is simple and cost effective. Numerous investigations have shown the effectiveness of basing treatment decisions on the inflammatory component of the airway by counting cells in sputum. Several studies have demonstrated that in patients with asthma, results of this analysis can guide in defining strategies to reduce exacerbations and to improve lung function even in patients with severe asthma, as well as to decrease the remodeling; in addition, a reduction in exacerbations in COPD patients

  15. Traducción, adaptación y validación al español del cuestionario de calidad de vida de 32 ítems (IBDQ-32) de la enfermedad inflamatoria intestinal Spanish translation, adaptation, and validation of the 32-item questionnaire on quality of life for inflammatory bowel disease (IBDQ-32)

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    M. Masachs; F. Casellas; Malagelada, J.R.

    2007-01-01

    Introducción: la medida de la calidad de vida relacionada con la salud (CVRS) tiene una reconocida importancia en la evaluación, el manejo y el seguimiento de la enfermedad inflamatoria intestinal. El instrumento de medida más utilizado es la versión de 32 ítems del Inflammatory Bowel Disease Questionnaire (IBDQ-32), que no está adaptado al español. Objetivo: traducir la versión del IBDQ-32 al español y determinar su validez, fiabilidad y sensibilidad tanto en la colitis ulcerosa como en la e...

  16. Tratamiento kinésico de la ruptura total del tendón del músculo supraespinoso con y sin intervención quirúrgica

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    Aldana, Emauel

    2015-01-01

    La ruptura total del tendón del músculo del supraespinoso es una lesión que ocurre por la existencia anterior de un proceso de naturaleza traumática, inflamatoria o degenerativa, quedando una zona vulnerable y dolorosa, presentando limitaciones articulares y debilidad muscular. Esta patología afecta con mayor frecuencia a personas de edades avanzadas. Objetivo general: Evaluar la evolución de los pacientes que sufrieron rupturas totales tendinosas del músculo supraespinoso con ...

  17. Valoración isocinética de los músculos rotadores del complejo articular del hombro en jugadores de balonmano playa

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    Zapardiel Cortés, Juan Carlos

    2015-01-01

    En el presente estudio se ha realizado una valoración de la fuerza de los músculos rotadores del complejo articular del hombro mediante dinamometría isocinética. La valoración se llevó a cabo en tres grupos: un grupo de mujeres que no practican deportes de lanzamiento o remate por encima de la cabeza, un grupo de hombres en la misma situación que el grupo anterior, y un grupo de jugadores de balonmano playa. Para que la investigación se realizase de forma fiable, válida y objetiva se utilizó ...

  18. Response of first attack of inflammatory bowel disease requiring hospital admission to steroid therapy Respuesta al tratamiento esteroideo del primer brote de enfermedad inflamatoria intestinal que requiere ingreso hospitalario

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    M. Abu-Suboh Abadía

    2004-08-01

    buena en caso de remisión completa o mala si la remisión es parcial o ausente. Se realizó estudio univariado y multivariado según estadística no paramétrica de diferentes variables sociodemográficas y biológicas. Resultados: se han incluido 45 pacientes con EC y 41 con CU. La tasa de buena respuesta fue del 64,4% en la EC y del 60,9% en la CU. El análisis univariado demostró que los pacientes con buena respuesta tienen un tiempo de evolución más corto y un menor número de brotes previos (p < 0,05 para la EC. Sin embargo, el análisis multivariado no demostró que alguna variable de las analizadas tuviera valor predictivo. Conclusión: la respuesta de los brotes graves de enfermedad inflamatoria intestinal a los corticoides es alrededor del 60% en la EC y CU. Los datos del presente estudio no permiten predecir qué pacientes son los que responderán al tratamiento.

  19. Valoración de la eficacia terapeútica del lavado articular en el tratamiento sintomático de pacientes con artrosis de rodilla

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    Frías Tejederas, Gabriel

    2006-01-01

    En el tratamiento de la osteoartrosis de orilla (OA) se están ensayando diferentes modalidades terapéuticas, siendo el lavado articular, técnica consistente en hacer pasar suero fisiológico, frío a través de la articulación de la rodilla, un procedimiento ampliamente aceptado para el tratamiento de esta patología. OBJETIVOS Valorar la eficacia del lavado articular en el tratamiento sintomático de pacientes con artrosis de rodilla. PACIENTES Y MÉTODOS Estudio prospectivo de 145 pacientes delos...

  20. Respuesta inflamatoria de la Célula Acinar a diferentes lípidos generados en grasa necrotica durante la pancreatitit aguda

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    Mateu Rico, Alberto

    2016-01-01

    [ES] La pancreatitis aguda (PA) es una enfermedad inflamatoria del páncreas en la que tiene lugar la secreción anormal al intersticio pancreático de enzimas digestivas como lipasas y fosfolipasas. Durante la PA se liberan grandes cantidades de ácidos grasos (AGs) y fosfolípidos (FLs) desde grasa peripancreática, habiéndose demostrado su capacidad para modular la respuesta inflamatoria. Como resultado del daño inicial del páncreas, se produce un reclutamiento masivo de leucocitos hacia la glán...

  1. Osteoporosis y enfermedad inflamatoria intestinal Osteoporosis and inflammatory bowel disease

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    L. Menchén

    2005-02-01

    Full Text Available La enfermedad inflamatoria intestinal es una entidad crónica de etiología desconocida en cuyo desarrollo influyen múltiples variables, como son la susceptibilidad individual, genética e inmunológica, así como diferentes factores ambientales. Sus manifestaciones clínicas son muy variadas y pueden afectar a otros órganos diferentes del tracto digestivo, convirtiéndose por tanto en una enfermedad multisistémica. En los últimos años existe un interés creciente por una de estas manifestaciones, la osteoporosis y la osteopenia, que puede afectar hasta al 42% de los pacientes y condiciona un importante aumento de la morbilidad. La inactividad, el tratamiento corticoideo prolongado, las deficiencias nutricionales y la propia enfermedad pueden favorecer el desarrollo de esta complicación. En esta revisión se repasan aspectos clínicos y etiológicos de la osteoporosis asociada a la enfermedad inflamatoria intestinal y se ofrecen pautas para su diagnóstico y tratamiento.Inflammatory bowel disease is a chronic disease with an unknown ethiology although multiple factors intervene such as individual, genetic and immunologic susceptibility, as well as different environmental factors. Like other multisystemic diseases, its clinical manifestations are diverse and it may affect other organs besides the gastrointestinal tract. In the last few years there is a growing interest for one of these extraintestinal manifestations, osteoporosis and osteopenia that may affect up to 42% of patients and can condition an important increase in morbility. Inactivity, prolonged corticosteroid treatment, nutritional deficiencies and the disease per se have an important role in the development of this complication. This article reviews clinical and ethiological aspects of inflammatory bowel disease associated osteoporosis and offers a strategy for diagnosis and treatment.

  2. Tuberculosis extrapulmonar: Forma articular

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    Julio C Escarpanter Buliés; Yoel García Rodríguez; Marta A. Gutiérrez Guillén

    2008-01-01

    Se realizó una revisión del tema de la Tuberculosis extrapulmonar de forma articular, por haber encontrado un paciente con esta patología de presentación "pura" sin otras manifestaciones sistémicas. Se trata del primer paciente diagnosticado en el Hospital Comunitario Integral de "San Andrés", del municipio de Caracollo, provincia Cercado, en el departamento de Oruro, Bolivia. En la revisión del tema se demuestra la infrecuencia de esta forma de presentación de la enfermedad a pesar de ser la...

  3. Enfermedad inflamatoria pélvica y adolescencia Pelvis inflammatory disease and the adolescence

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    Jorge Peláez Mendoza

    2012-01-01

    Se conoce como enfermedad inflamatoria pélvica (EIP) a la infección del tracto genital superior, incluye las distintas fases evolutivas del proceso infeccioso, así como la participación de cualquiera de sus localizaciones, la inflamación de las trompas de Falopio es la forma más común. Esta entidad puede aparecer en cualquier momento de la vida reproductiva de la mujer, pero es mucho más alto el riesgo de aparición durante la adolescencia y juventud, se acepta que en las menores de 20 años es...

  4. Lesiones del cartílago articular de la rodilla en zona de carga. Artroscopia en 120 pacientes: Arthroscopy in 120 patients Lesions of the articular cartilage of the knee in a burden zone

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    Guillermo Reyes Chirino

    2005-03-01

    Full Text Available Se realizó un estudio retrospectivo en el Hospital Universitario "Abel Santamaría Cuadrado" de Pinar del Río en el periodo de enero/1999 a enero/2003 en 120 pacientes atendidos en el servicio de Ortopedia y Traumatología que presentaron lesiones del cartílago articular de las rodillas en zonas de carga de peso, tratados por cirugía artroscópica; con el objetivo de evaluar los factores que influyeron en la evolución de estos pacientes. De la muestra solo el 13.3 % fueron excelentes, el 35 % se evaluaron de bien, mientras el 38.3 % fueron regular y el 13.3 % con malos resultados. El peso corporal, las deformidades angulares de las rodillas, otras lesiones mecánicas asociadas, el estado de la masa muscular y la extensión y profundidad de las lesiones cartilaginosas influyeron notablemente en la evolución de estos pacientes según nuestros resultados así como la edad y el sexo.A retrospective study is performed at Abel Santamaría Cuadrado Hospital in Pinar del Río from January 1999 to January 2003 in 120 patients assisted in the Service of Orthopedics and Traumatology who presented with lesions in the articular cartilage of the knee in weight load areas, managed with asthroscopic surgery, in order to evaluate the factor which influenced the progress of these patients. Out of the sample, only 13.3 % was excellent, 35 % was good, whereas 38.3 % was not good and 13.3 % was poor. Body weight, knee angular deformities, other related mechanic lesions significantly influenced the progress of these patients, according to our results as well as age and sex.

  5. Tratamiento del paciente con artrosis

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    Francisco Vargas Negrín

    2014-01-01

    Full Text Available El manejo terapéutico del paciente con artrosis tiene como objetivo disminuir la sintomatología dolorosa e inflamatoria, mejorar la capacidad funcional del paciente y la aplicación de intervenciones terapéuticas eficaces y lo más seguras posibles. Un enfoque centrado en el paciente implica su participación activa en el diseño del plan terapéutico y en la toma de decisiones informadas oportunas en todas las etapas de la enfermedad. La educación terapéutica, la actividad física y el ejercicio terapéutico junto con el control de peso, en caso de sobrepeso u obesidad, constituyen el núcleo central del tratamiento. Los autocuidados individuales y por los familiares son fundamentales en el control del día a día del paciente. El uso de terapias físicas, ayudas técnicas (bastón, etc. y de fármacos tipo analgésicos simples, opioides y antiinflamatorios tiene evidencias demostradas en el control del dolor, mejora la funcionalidad y la calidad de vida del paciente y una clara recomendación de uso en el tratamiento de la artrosis. La cirugía conservadora y la de reemplazo articular se indican en los casos en los que no se logran los objetivos terapéuticos en casos concretos.

  6. Ingeniería tisular en el cartílago articular: Estudio in vivo del proceso de regeneración mediante Scaffolds bioestables.

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    Forriol Brocal, Francisco

    2010-01-01

    La prevalencia de las lesiones del cartílago articular tanto degenerativas como post-traumáticas se considera elevada. Teniendo en cuenta que se trata de un tejido avascular e hipocelular, su capacidad de respuesta reparativa mediante mecanismos biológicos se encuentra limitada. Muchas de las técnicas quirúrgicas empleadas en la actualidad para el tratamiento de dichas lesiones permiten obtener tejido fibrocartilaginoso. Las técnicas en las que se emplean soportes macroporosos, andamiaje...

  7. Hiperplasia Fibrosa Inflamatoria: reporte de un caso Inflammatory Fibrous Hyperplasia: case report

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    A Casian Romero; P Trejo Quiroz; C De León Torres; D Carmona Ruiz

    2011-01-01

    Introducción: La Hiperplasia Fibrosa Inflamatoria es una alteración caracterizada por un agrandamiento del tejido conectivo; se considera una lesión reactiva ya que se presenta como respuesta a una irritante crónico local; es una lesión común en pacientes adolescentes y de edad adulta debido a que su etiología principal se asocia a maloclusión, al uso de aparatología protésica u ortodóntica mal ajustada, así como a la presencia de biofilm. Sin embargo, la población infantil, principalmente en...

  8. Desarrollo de un nuevo medicamento con acetato de hidrocortisona para el tratamiento de la enfermedad inflamatoria intestinal (EII)

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    Ascaso Anglés, Magda

    2015-01-01

    El objetivo principal de este estudio consiste en la investigación y desarrollo de la formulación de un nuevo medicamento semisólido con acetato de hidrocortisona en forma farmacéutica de enema rectal. Esta formulación pretende cubrir un vacío terapéutico en el tratamiento de la Enfermedad inflamatoria intestinal, en concreto la colitis ulcerosa. Para ello es necesario tener en cuenta las especificaciones indicadas en la modificación de la Ley del Medicamento y posteriores circulares del Mini...

  9. Traducción, adaptación y validación al español del cuestionario de calidad de vida de 32 ítems (IBDQ-32 de la enfermedad inflamatoria intestinal Spanish translation, adaptation, and validation of the 32-item questionnaire on quality of life for inflammatory bowel disease (IBDQ-32

    Directory of Open Access Journals (Sweden)

    M. Masachs

    2007-09-01

    Full Text Available Introducción: la medida de la calidad de vida relacionada con la salud (CVRS tiene una reconocida importancia en la evaluación, el manejo y el seguimiento de la enfermedad inflamatoria intestinal. El instrumento de medida más utilizado es la versión de 32 ítems del Inflammatory Bowel Disease Questionnaire (IBDQ-32, que no está adaptado al español. Objetivo: traducir la versión del IBDQ-32 al español y determinar su validez, fiabilidad y sensibilidad tanto en la colitis ulcerosa como en la enfermedad de Crohn. Método: estudio prospectivo en dos fases: traducción y posterior validación del IBDQ-32 al español. La traducción se ha basado en la versión al español validada del IBDQ-36, y los ítems del IBDQ-32 no incluidos en el IBDQ-36 se tradujeron "de novo". Una vez terminada la traducción del IBDQ32, se aplicó un cuestionario específico de comprensión. Para determinar las propiedades psicométricas del IBDQ-32, un grupo de pacientes completó el IBDQ-36 ya validado al español y el IBDQ-32. Resultados: se han incluido 84 pacientes (53 con enfermedad de Crohn y 31 con colitis ulcerosa. La mediana de la puntuación global de ambos cuestionarios en los 84 pacientes no fue diferente (6,1 vs. 6,2, p = ns y su correlación de Spearman fue muy significativa (r = 0,97, p Introduction: the measurement of health-related quality of life (HRQoL has an established relevance in the assessment, management, and follow-up of inflammatory bowel disease. The most commonly used measuring instrument is the 32-item version of Inflammatory Bowel Disease Questionnaire (IBDQ-32, which has never been adapted to Spanish. Objective: to translate IBDQ-32 into Spanish, and to establish its validity, reliability, and sensitivity both in ulcerative colitis and Crohn's disease. Method: a prospective study in two phases -translation into Spanish and subsequent validation of IBDQ-32. Translation was based on the validated Spanish version of IBDQ-36, and IBDQ-32

  10. Neuritis óptica inflamatoria Inflammatory optic neuritis

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    T. Ayuso

    2009-08-01

    Full Text Available La neuritis óptica inflamatoria (NO es la causa más frecuente de pérdida visual aguda en adultos jóvenes. Aunque el pronóstico visual es excelente en la mayoría de los casos, muchos pacientes desarrollarán otra patología como esclerosis múltiple en la evolución posterior. La historia natural de la NO ha sido estudiada en múltiples trabajos en los últimos años; uno de los más importantes es el Optic Neuritis Treatment Trial. La Resonancia Magnética tiene un papel fundamental en el diagnóstico etiológico de la NO y en la predicción del riesgo de conversión a esclerosis múltiple. Recientemente se han incorporado nuevas técnicas exploratorias como la tomografia de coherencia óptica, útil para el diagnóstico y pronóstico; se han identificado biomarcadores séricos que ayudan en el diagnóstico de otras patologías de naturaleza autoinmune que producen NO. Un mejor conocimiento de los datos clínicos y exploratorios de la NO típica permitirá un estudio diagnóstico más rápido y certero. El tratamiento de la NO con esteroides debe ser individualizado teniendo en cuenta que no modifican el pronóstico a largo plazo y en pacientes con alto riesgo de conversión a esclerosis múltiple debe plantearse terapia inmunomoduladora. Este trabajo revisa los datos existentes en la literatura referentes a las manifestaciones clínicas, el diagnóstico etiológico y diferencial y tratamiento de la NO inflamatoria.Inflammatory Optic Neuritis (ON is the most frequent cause of acute visual loss in young adults. Although the visual prognosis is excellent in the majority of cases, many patients develop pathology, such as multiple sclerosis, in its subsequent evolution. The natural history of ON has been studied in numerous works in recent years; one of the most important of which is Optic Neuritis Treatment Trial. Magnetic Resonance plays a fundamental role in the etiological diagnosis of ON and in predicting the risk of conversion into

  11. Amiloidosis secundaria en la enfermedad inflamatoria intestinal Secondary amyloidosis in Chrohn's disease

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    S. Seijo Ríos

    2008-12-01

    Full Text Available La amiloidosis es una entidad clínica que se produce a consecuencia del depósito a nivel extracelular de un material proteico amorfo, causando una desorganización de la arquitectura normal de múltiples órganos y tejidos y, por tanto, una alteración funcional de los mismos. La amiloidosis secundaria es una complicación infrecuente pero muy grave que aparece en el contexto de neoplasias, enfermedades infecciosas e inflamatorias de curso crónico, como es el caso de la enfermedad inflamatoria intestinal, principalmente enfermedad de Crohn, ensombreciendo el pronóstico de estos pacientes. A continuación presentamos dos casos clínicos correspondientes a dos pacientes con enfermedad de Crohn que desarrollaron amiloidosis secundaria.Amyloidosis is a clinical entity that results from the deposition of an extracellular protein material that causes disruption in the normal architecture of multiple organs and tissues, and impairs their function. Secondary amyloidosis is a rare but serious complication that may worsen the prognosis of patients with cancer, infection or chronic inflammatory disease, including inflammatory bowel disease, particularly Crohn's disease. We report two cases of Crohn's disease associated with secondary amyloidosis.

  12. Estudio Transversal sobre la Relación entre Neuroticismo y Curso Clínico en Pacientes con Enfermedades Inflamatorias Intestinales

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    Juan Carlos Fernández Méndez

    2010-01-01

    Full Text Available En el presente trabajo se analiza la relación que existe entre neuroticismo y diversas condiciones médicas que hacen referencia al curso clínico de las enfermedades inflamatorias intestinales. Para desarrollar la investigación se tomaron medidas en neuroticismo mediante el Inventario de Personalidad de Eysenck a 106 participantes diagnosticados de colitis ulcerosa y enfermedad de Crohn. Los resultados reflejaron que la muestra global de pacientes con enfermedades inflamatorias intestinales mostraba valores en neuroticismo que se hallaban dentro de la normalidad; sin embargo, se pudo verificar que los valores diferían dependiendo del curso clínico de la patología. El estudio sugiere que las variaciones en neuroticismo son considerables cuando se analizan los datos de la muestra general y cuando se tienen en cuenta diversas condiciones del curso clínico.

  13. Manifestaciones reumatológicas de la enfermedad inflamatoria intestinal Rheumatologic manifestations of inflammatory bowel disease

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    Octavio Germán Muñoz Maya

    2006-01-01

    Full Text Available La enfermedad inflamatoria intestinal (EII se caracteriza por la activación inapropiada del sistema inmune de la mucosa intestinal y sus dos formas de presentación son: la colitis ulcerativa y la enfermedad de Crohn. Las manifestaciones extraintestinales se presentan hasta en el 36% de los pacientes y pueden comprometer cualquier órgano o sistema. La disfunción inmune se caracteriza por el desequilibrio entre los mediadores proinflamatorios y los antinflamatorios y se expresa como una enfermedad sistémica. Las manifestaciones reumatológicas asociadas a la EII son de tres tipos: la artritis periférica, la espondiloartropatía y una tercera categoría que incluye lesiones dérmicas, oftálmicas y del metabolismo óseo, entre otras. El manejo de estas manifestaciones se basa en la terapia sistémica para el control de la actividad inflamatoria local utilizando esteroides, derivados de la 5-ASA, inmunomoduladores y, en los últimos años, terapia anti-TNF. The main feature of inflammatory bowel disease (IBD is the continuous activation of the mucosa-associated immune system; the disease has two major forms of presentation: ulcerative colitis and Crohn´s disease. The extraintestinal manifestations are present in 36% of patients, and any organ can be affected. There is an imbalance between proinflammatory and antinflammatory cytokines leading to a systemic disease. The rheumatologic manifestations of the IBD are: Peripheral arthritis, spondyloarthropathy and a third category that includes dermic and ocular lesions as well as metabolic bone disease. Control of the extraintestinal manifestations is based on systemic therapy with steroids, 5-ASA derivatives and biological anti-TNF therapy.

  14. Tuberculosis extrapulmonar: Forma articular

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    Julio C. Escarpanter Buliés

    2008-06-01

    Full Text Available Se realizó una revisión del tema de la Tuberculosis extrapulmonar de forma articular, por haber encontrado un paciente con esta patología de presentación "pura" sin otras manifestaciones sistémicas. Se trata del primer paciente diagnosticado en el Hospital Comunitario Integral de "San Andrés", del municipio de Caracollo, provincia Cercado, en el departamento de Oruro, Bolivia. En la revisión del tema se demuestra la infrecuencia de esta forma de presentación de la enfermedad a pesar de ser la Tuberculosis pulmonar frecuente en la región por sumarse los factores: frío, altura con poco tenor de oxígeno, desnutrición, tormentas de polvo, muchos trabajadores mineros, etc. Se realiza la presentación del paciente, se muestra su evolución satisfactoria en cuanto a la patología de base y se arriban a conclusiones dentro de las que se destacan que la Tuberculosis en su forma articular es infrecuente en apariencia y su diagnóstico se hace difícil al no existir, por la misma razón, patrones ecográficos o radiográficos definidos. El diagnóstico anatomopatológico es el único que puede definir la etiología de la Tuberculosis de una lesión proliferativa de la sinovial y que la sinovectomía es una intervención generalmente invalidante por lo que un diagnóstico precoz y un tratamiento médico adecuado, a tiempo, evitaría limitaciones funcionales a posteriori. Se recomienda que en todo caso portador de una sinovitis de rodilla de larga evolución, se le realice una ecografía diagnóstica, y en los pacientes en los que se observen imágenes complejas de bordes regulares, del tipo "copos de nieve", se le efectúen estudios específicos para la detección de la Tuberculosis.

  15. Proyecciones radiológicas de muñeca para visualizar adecuadamente la superficie articular del radio en fracturas de radio distal “de acuerdo a ángulos hallados mediante modelos virtuales 3D”

    OpenAIRE

    Penagos López, Rodrigo Alberto

    2012-01-01

    La fractura del radio distal es una patología frecuente que muchas veces requiere tratamiento quirúrgico. Este puede realizarse con placas y tornillos, en donde es importante visualizar la adecuada posición del material de osteosíntesis. Se necesita tener unas proyecciones radiológicas que permitan ver adecuadamente la superficie articular sin interposición de estructuras para tener plena seguridad de la posición de los tornillos extraarticulares, para lo cual se propone una nueva proye...

  16. Recomendaciones de vacunación en pacientes con enfermedad inflamatoria intestinal (EII

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    C. Rodríguez

    2013-04-01

    Full Text Available El concepto de enfermedad inflamatoria intestinal (EII engloba tres entidades: la colitis ulcerosa (CU, la enfermedad de Crohn (EC y la colitis inclasificable (CI. Estas enfermedades tienen en común el curso crónico y recidivante, alternando épocas de marcada actividad inflamatoria con otras quiescentes, en las que el paciente permanece asintomático. Durante muchos años la base del tratamiento, sobre todo en las fases agudas, se basó en el uso de corticoides. Sin embargo, a lo largo de las últimas décadas hemos asistido a avances importantes desde el punto de vista terapéutico. Así se estima que, a lo largo de la evolución de la enfermedad, el 80% de los pacientes van a precisar corticoides, el 40% inmunomoduladores (IMM y hasta un 20% necesitará un fármaco biológico para el control de su enfermedad. Si bien todo ello se acompaña de una mejora en la calidad de vida, disminuyendo la necesidad de ingresos e intervenciones quirúrgicas, su uso implica también un incremento en el riesgo de sufrir infecciones, bien por gérmenes habituales en la comunidad o por gérmenes oportunistas. Las infecciones, además, son causa de morbimortalidad asociada a EII y algunas de ellas son prevenibles con vacunas, de ahí la importancia que los programas de vacunación están adquiriendo en este grupo de pacientes. Presentamos una revisión de la literatura al respecto y proponemos unas recomendaciones de vacunación para los pacientes diagnosticados de EII.

  17. Efficacy of intravenous iron in treating iron deficiency anaemia in patients with inflammatory bowel disease: Are there predictors of response? Eficacia del hierro intravenoso en el tratamiento de la anemia ferropénica en pacientes con enfermedad inflamatoria intestinal: ¿Existen factores predictivos de respuesta?

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    Rocío Ferreiro Iglesias

    2011-05-01

    Full Text Available Introduction: in inflammatory bowel disease (IBD iron deficiency anaemia (IDA is a very common disorder. Until recently, oral iron has been the mainstay therapy, nevertheless it has been associated with intolerance and noncompliance. Therefore, the goal of our study was to evaluate the efficacy of intravenous iron in IDA in IBD patients and the secondary aim was to investigate whether other potential factors could influence in the response to the treatment. Design: an open-label, prospective, consecutive, single centre study. Material and methods: we performed our study in patients with ulcerative colitis (UC or Crohn's disease (CD with severe anaemia or intolerance with oral iron. All of them received intravenous sacarose iron and did biochemistry profile with haemoglobin (Hb. Moreover, the correlation with other variables was studied: age, sex, smoking habit, IBD type, previous surgery and type of surgery and other treatments. Response was defined as Hb increase of ≥ 2 g/dL or normalization of the levels. Results: fifty-four patients were included into the study, 34 (63% with UC y 20 (37% with CD, 18 (33.3% men and 36 women (66.6% and the average was 48 ± 14 years. The total proportion of responders was 52% (SD ± 05; 43% of the patients reached Hb ≥ 2 g/dl and y 9% of them normalized Hb. Only the utilization of 5-ASA was associated with low response to iron treatment (p Introducción: la anemia por déficit de hierro es un problema frecuente en la enfermedad inflamatoria intestinal (EII. Un número no despreciable de pacientes no responde o presenta intolerancia al hierro oral. El objetivo de nuestro estudio es evaluar la eficacia del hierro sacarosa intravenoso (Venofer® en los pacientes con EII así como los potenciales factores que pueden influir en la respuesta al mismo. Diseño: estudio abierto, unicéntrico y con una inclusión consecutiva de casos. Material y métodos: se incluyeron pacientes con colitis ulcerosa (CU y enfermedad

  18. Impacto de la enfermedad inflamatoria intestinal sobre la sexualidad

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    Carrera Alonso, Elisa

    2015-01-01

    Introducción. La enfermedad inflamatoria intestinal (EII) tiene un impacto significativo en la calidad de vida de los pacientes que la padecen. Aunque parece razonable pensar que la enfermedad puede tener un impacto negativo sobre la sexualidad, existe escasa evidencia sobre este tema. Con nuestro estudio pretendemos aclarar algunas de estas incógnitas. Hipótesis y Objetivos. Se planteó si los pacientes con EII tenían una calidad de vida sexual alterada en los momentos en los que su enfermed...

  19. Nutrición y enfermedad inflamatoria intestinal Nutrition and inflammatory bowel disease

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    E. Cabré Gelada

    2007-05-01

    Full Text Available En este artículo se revisan las causas y consecuencias de los déficits nutricionales en la enfermedad inflamatoria intestinal, con especial énfasis en sus implicaciones fisiopatológicas. Además, se sientan las bases de la intervención nutricional en estos pacientes tanto desde la perspectiva del consejo dietético como del uso de soporte nutricional especializado. Se hace un especial hincapié en la discusión de las evidencias existentes en favor de un papel terapéutico primario de la nutrición artificial y algunos nutrientes específicos en la enfermedad de Crohn.In this paper, the causes and consequences of nutritional deficiencies in inflammatory bowel disease are reviewed. Particular emphasis is made on their pathophysiological implications. In addition, the basis for nutritional intervention in these patients are described (both in terms of dietary counseling and the use of specialized nutritional support. Particular mention is made on the current evidences in favour of a primary therapeutic role of artificial nutrition and some specific nutrients in Crohn's disease.

  20. Imaging of articular cartilage

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    Bhawan K Paunipagar

    2014-01-01

    Full Text Available We tried to review the role of magnetic resonance imaging (MRI in understanding microscopic and morphologic structure of the articular cartilage. The optimal protocols and available spin-echo sequences in present day practice are reviewed in context of common pathologies of articular cartilage. The future trends of articular cartilage imaging have been discussed with their appropriateness. In diarthrodial joints of the body, articular cartilage is functionally very important. It is frequently exposed to trauma, degeneration, and repetitive wear and tear. MRI has played a vital role in evaluation of articular cartilage. With the availability of advanced repair surgeries for cartilage lesions, there has been an increased demand for improved cartilage imaging techniques. Recent advances in imaging strategies for native and postoperative articular cartilage open up an entirely new approach in management of cartilage-related pathologies.

  1. Eficácia analgésica do uso de dose alta de morfina intra-articular em pacientes submetidos à artroplastia total de joelho Eficacia analgésica del uso de dosis alta de morfina intra-articular en pacientes sometidos a la artroplastia total de rodilla Analgesic efficacy of the intra-articular administration of high Doses of morphine in patients undergoing total knee arthroplasty

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    João Batista Santos Garcia Garcia

    2010-02-01

    demostrado que las dosis mayores generan mejores resultados y consecuentemente, un menor consumo postoperatorio de analgésico, caracterizando así, el efecto dosis-dependiente en la acción periférica. Fue realizado un estudio controlado, aleatorio y doble ciego para evaluar la eficacia de 10 mg de morfina por vía intraarticular en pacientes sometidos a la artroplastia total de rodilla. MÉTODO: Se evaluaron 50 pacientes sometidos a la artroplastia total de rodilla, distribuidos aleatoriamente en dos grupos: el grupo tratamiento recibió 10 mg (1 mL de morfina por vía intra-articular diluido en 19 mL de solución fisiológica al 0,9% (SF, mientras que el grupo control recibió una inyección intra-articular con 20 mL de SF, ambos después del cierre de la cápsula articular, al final de la operación. La morfina subcutánea bajo demanda, estuvo disponible para el dolor residual. Se evaluaron las siguientes variables: intensidad del dolor graduada en la Escala Numérica (EN a las 2h (M1, 6h (M2, 12h (M3 y 24h (M4, después de la inyección IA; tiempo para la primera solicitación de analgésico; y consumo de analgésicos y efectos adversos. CONCLUSIONES: El grupo tratamiento presentó menores valores en la EN que el grupo control en M1 y M2, mientras que en los otros momentos, no se registró ninguna diferencia significativa. El intervalo para la primera solicitación de analgésicos fue significantemente mayor en el grupo tratamiento y el consumo de analgésicos en las primeras 24 horas fue menor en ese grupo. No hubo diferencia entre la incidencia de efectos adversos entre los grupos. Llegamos a la conclusión, de que 10 mg de morfina redujeron el dolor del postoperatorio entre 2 y 6 horas después de aplicada la inyección IA, y se generó un periodo mayor sin analgésico de rescate reduciendo su consumo en las primeras 24 horas.BACKGROUND AND OBJECTIVES: Although the efficacy of intraarticular (IA morphine is still controversial, it has been shown that higher doses

  2. Intra articular synovial sarcoma

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    Sistla Radha

    2010-01-01

    Full Text Available Synovial sarcoma is a soft tissue neoplasm with a characteristic biphasic pattern. Incidence in soft tissues is 5-10%. Intra articularly synovial sarcoma is extremely rare. Fewer than 5% of all synovial sarcomas arise within the joint space. We report a case of intra articular synovial sarcoma in a young male who presented as internal derangement of the knee.

  3. Intra articular synovial sarcoma

    OpenAIRE

    Sistla Radha; Tameem Afroz; Vidyasagar JVS

    2010-01-01

    Synovial sarcoma is a soft tissue neoplasm with a characteristic biphasic pattern. Incidence in soft tissues is 5-10%. Intra articularly synovial sarcoma is extremely rare. Fewer than 5% of all synovial sarcomas arise within the joint space. We report a case of intra articular synovial sarcoma in a young male who presented as internal derangement of the knee.

  4. Estudio PET/TC en patología inflamatoria-infecciosa PET/CT in infectious and inflammatory pathology

    OpenAIRE

    Cecilia Carrera; Silvina de Luca; Laura Tisser; Mariana Jakubowicz; Emilia Casalini Vañek; Eduardo Eyheremendy

    2012-01-01

    Objetivo. Demostrar la utilidad del examen PET/TC en patología inflamatoria-infecciosa. Materiales y Métodos. Evaluación retrospectiva (enero de 2009 - mayo de 2011) de los exámenes de tomografía por Emisión de Positrones/ Tomografía Computada (PET/TC), realizados en nuestra institución con un equipo híbrido SIEMENS-BIOGRAPH 16 (Siemens, Erlangen, Alemania). Se seleccionaron 5 pacientes. Resultados. Caso 1: paciente de 68 años de edad con fiebre de 6 meses de duración, fatiga y pérdida de pes...

  5. Síndrome de respuesta inflamatoria sistémica como indicador pronóstico en pacientes cirróticos hospitalizados

    OpenAIRE

    Nancy Roxana Machaca Quea; Sonia Salazar Ventura; Pedro Montes Teves

    2014-01-01

    Objetivo: La inflamación sistémica empeora los trastornos circulatorios en el paciente cirrótico y recientemente el síndrome de respuesta inflamatoria sistémica (SRIS) podría ser un indicador pronóstico en ellos. El objetivo del estudio fue determinar si la presencia de SRIS al ingreso en pacientes cirróticos hospitalizados está asociada a complicaciones o mortalidad. Materiales y métodos: Estudio de cohortes retrospectiva, realizado en el Hospital Nacional Daniel Alcides Carrión. Se admitier...

  6. CARACTERÍSTICAS INFLAMATORIAS DE LA OBESIDAD INFLAMMATORY CHARACTERISTICS OF OBESITY

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    Marcela Reyes J

    2010-12-01

    Full Text Available Actualmente la obesidad es considerada una enfermedad inflamatoria crónica, de intensidad leve. Las alteraciones que ocurren en el tejido adiposo en expansión son muy similares a las de una inflamación clásica, sin embargo se desconoce aún el agente lesivo que lo gatilla. La activación del sistema inmune no se da solamente en el tejido adiposo, sino que es identificable a nivel circulatorio y en los diferentes órganos relacionados con el metabolismo de sustratos como son hígado, páncreas y músculo. Los antecedentes actuales permiten plantear que tanto la génesis como la evolución de las enfermedades crónicas asociadas a la obesidad tienen un componente inflamatorio. El objetivo de este ensayo es revisar el conocimiento actual sobre el tema. Una cabal comprensión de la activación del sistema inmune en condiciones de exceso nutricional posibilitará su monitorización y eventual intervención.Currently, obesity is considered a low chronic inflammatory state. The alterations that occur into the expanding adipose tissue parallel the ones seen in a classic inflammatory process. However, the stimulus that triggers inflammation is still unknown. The consequences of the immune system activation are poorly understood. The inflammatory process is not just present at the adipose tissue level. In fact, it can be found in circulation, pancreas, liver and muscle (among other organs. Moreover, inflammation is playing a role on the path physiology of most of cardiovascular risk factors linked to obesity. The aim of this article was to review the current knowledge about this important topic. The understanding of the immune process linked to obesity would allow its clinic study and even the intervention.

  7. Pelvic inflammatory disease Enfermedad inflamatoria pélvica

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    Regla Fang Mederos

    2007-02-01

    Full Text Available

    A bibliographical revision on the main topics referred to the acute pelvic inflammatory disease which includes definition, risk factors, diagnosis, and treatment with the objective to create a supporting educational aid to the teaching of students of 4th and 6th year of the medicine and nursing specialty in their rounds on the services of gynecology and obstetrics.

    Revisión bibliográfica sobre los principales temas referidos a la enfermedad inflamatoria pélvica aguda que incluye concepto, factores de riesgo, cuadro clínico, diagnóstico y tratamiento, con el objetivo de crear un material de apoyo a la docencia de estudiantes de cuarto y sexto año de la especialidad de medicina y de enfermería en su rotación por los Servicios de Ginecología y Obstetricia.

  8. Enfermedad inflamatoria intestinal: situación actual de las alternativas terapéuticas

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    Lucrecia Suárez

    2007-03-01

    Full Text Available La enfermedad inflamatoria intestinal (EII se caracteriza por tener un curso clínico impredecible alternando recaídas con períodos de inactividad, una respuesta muy variable a la terapia y la constante aparición de complicaciones diversas. Su manejo es particularmente complejo en el niño y si bien existen diferentes guías y recomendaciones disponibles, los ensayos clínicos realizados en este grupo de edad son limitados y la evidencia científica es contradictoria, por lo cual aún no se cuenta con un consenso terapéutico aceptado internacionalmente. Los objetivos generales del tratamiento consisten en inducir y mantener la enfermedad en remisión el mayor tiempo posible, conseguir un adecuado crecimiento y prevenir posibles complicaciones. En años recientes, la aparición de nuevas alternativas terapéuticas ha permitido darle un enfoque más integral al manejo de estos pacientes tomando también en consideración el estado nutricional y psicológico además de su calidad de vida. Estos tratamientos, si bien consiguen en muchos casos controlar la inflamación intestinal curando las lesiones de la mucosa, no están exentos de efectos secundarios a corto y largo plazo, motivo por el cual es imprescindible tomar en cuenta las características de cada paciente para poder ofrecer un tratamiento individualizado que sea capaz de modificar la evolución natural de la enfermedad.

  9. Tratamiento nutricional en la enfermedad inflamatoria intestinal Nutritional management of inflammatory bowel disease

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    C. Pérez Tárrago

    2008-10-01

    Full Text Available Los pacientes con enfermedad inflamatoria intestinal presentan mayor riesgo de malnutrición. Por este motivo es muy frecuente que se precise un adecuado soporte nutricional. En estos pacientes se debe utilizar la nutrición enteral a menos que existan contraindicaciones. El soporte nutricional como tratamiento primario no está indicado en adultos (al haberse demostrado una mayor eficacia del tratamiento esteroideo salvo en caso de intolerancia o falta de respuesta al tratamiento médico. Por el contrario, la nutrición enteral se considera el tratamiento de primera línea en niños. No existe un claro beneficio con el uso de fórmulas específicas (grasa modificada, glutamina... por lo que no se aconseja su uso rutinario. A pesar de los grandes avances técnicos y científicos existen aún numerosos campos en los que ampliar conocimientos; algunos de los mismos se esbozan en la presente publicación.Patients with inflammatory bowel disease present higher risk for hyponutrition. For this reason, an adequate nutritional support is frequently needed. In these patients, enteral nutrition should be used unless there exist contraindications. Nutritional support as the primary therapy is no indicated in adults (since steroidal therapy has shown to be more effective but in the case of intolerance or lack of response to medical treatment. By contrast, enteral nutrition is considered a first line therapy in children. There is no clear benefit with the use of specific formulas (modified fat, glutamine..., so that their routine use is not recommended. In spite of the great technical and scientific advances, there are still many fields in which knowledge should be broaden; some of them are pointed out in this publication.

  10. Articular cartilage stem cell signalling

    OpenAIRE

    Karlsson, Camilla; Lindahl, Anders

    2009-01-01

    The view of articular cartilage as a non-regeneration organ has been challenged in recent years. The articular cartilage consists of distinct zones with different cellular and molecular phenotypes, and the superficial zone has been hypothesized to harbour stem cells. Furthermore, the articular cartilage demonstrates a distinct pattern regarding stem cell markers (that is, Notch-1, Stro-1, and vascular cell adhesion molecule-1). These results, in combination with the positive identification of...

  11. Citocinas anti-inflamatorias y sus acciones y efectos en la sepsis y el choque séptico (Anti-inflammatory cytokines and their actions and effects in the sepsis and septic shock.

    Directory of Open Access Journals (Sweden)

    González Álvarez, Ricardo

    2009-08-01

    Full Text Available ResumenLas citocinas anti- inflamatorias reconocidas son las interleucinas (IL IL-4, IL-10, IL-6, IL-13, el factor estimulante de colonia granulocito –macrófago (FEC-GM y el interferón alfa (IFN-alfa, los cuales tienen la capacidad de inhibir la liberación de las citocinas pro-inflamatorias y de inducir la producción del antagonista del receptor de la IL-1 y la liberación del receptor soluble del FNT, los cuales limitan algunas de las actividades de las citocinas pro-inflamatorias IL-1 y FNT-α. Sin embargo, los eventos que ocurren durante la inflamación y la sepsis no son tan simples como parajustificar siempre acciones antagonistas entre las citocinas proinflamatorias y las anti-inflamatorias, las cuales, pueden tener acorde con las circunstancias un comportamiento dual y/o antagónico en el choque séptico. Así por ejemplo la IL-10 tiene propiedades anti-inflamatorias, lo cual ocurre en la diabetes auto-inmune cuyo comienzo y desarrollo son acelerados en ratones transgénicos que sobre-expresan la IL-10 en los islotes pancreáticos. Esto también ocurre con la IL-10 en un modelo de uveítis en el que se incrementó la inflamación ocular. Ejemplos como los anteriores son extensivos a otras citocinas anti-inflamatorias como la IL-4, IL-13, el factor estimulante de colonia granulocito –macrófago y el factor beta transformante del crecimiento (FβTC, y que serán mencionadas y descritas en el presente artículo de revisión, así como los factores que determinan ese comportamiento dual de las citocinas.Summaryinterleucinas. The anti-inflammatory cytokines which are recognized are the interleukins (IL IL-4, IL-10, IL-13, interferon-alpha (IFN-α and because they are able to inhibit the release of pro inflammatory cytokines, to induce the production of IL-1 receptor antagonist (IL-ra and the release of soluble TNF receptor and to limit some of the pro-inflammatory activities of IL-1 and TNF. However the events which occur during

  12. Donador exógeno de óxido nítrico en la respuesta inflamatoria hepática y hemodinámica después de choque hemorrágico

    OpenAIRE

    Roberto Anaya-Prado; Luis H. Toledo-Pereyra; Ren Feng Guo; Jayne Reuben; Ward, Peter A.

    2008-01-01

    Introducción: El choque hemorrágico resulta en estrés oxidativo celular e inducción de respuesta inflamatoria. Investigamos la capacidad del nitroprusiato de sodio para reducir la lesión tisular en un modelo animal de choque hemorrágico no controlado. Material y métodos: 72 ratas Sprague-Dawley distribuidas en cuatro grupos: sham/salina, sham/nitroprusiato de sodio, choque/ salina, choque/nitroprusiato de sodio. Se provocó choque hemorrágico (3 ml/100 g) en un periodo de 15 minutos; corte de ...

  13. Comportamiento de variables epidemiológicas en la neuropatía óptica inflamatoria infecciosa. Centro Oftalmológico de Holguín. 2009

    OpenAIRE

    Enma Estrella de la Torre-Rodríguez; María Eugenia Escobar-Pérez; Lismay Grin-Pupo; Félix Fuentes-Díaz

    2012-01-01

    Abordó un estudio descriptivo del comportamiento de algunas variables epidemiológicas en un universo de 18 pacientes con neuropatía óptica inflamatoria en el Centro Oftalmológico de Holguín de enero a diciembre de 2009. La muestra estuvo representada por 12 pacientes con etiología infecciosa. El mayor número de pacientes se incluyó en el grupo de edad de 15 a 29 años. Las ocupaciones de riesgo más frecuentes fueron los estudiantes, las amas de casa y criadores de palomas. Los perros, gatos y...

  14. Nuevos mecanismos protectores en la enfermedad inflamatoria intestinal sistema endocannabinoide y haptoglobina /

    OpenAIRE

    Márquez Mosquera, Lucía

    2012-01-01

    La Enfermedad Inflamatoria Intestinal (EII) (enfermedad de Crohn (EC) y Colitis Ulcerosa (CU)), es una enfermedad crónica, poligénica y compleja, de curso recurrente, que afecta al tracto gastrointestinal. Estudios recientes in vitro y modelos experimentales en animales sugieren que el Sistema Endocannabinoide (SE) y la Haptoglobina (Hp) pueden tener un papel protector en la EII. Estudio 1: Sistema Endocannabinoide y EII Se analizó, mediante Western-Blot e inmunohistoquímica, la pre...

  15. El concepto de contacto articular alternativo de la rodilla

    OpenAIRE

    Pichel Moure, C.M.

    1994-01-01

    La observación radioscópica de la interlínea articular de rodillas de cadáveres sin anomalías anatómicas durante movimientos de abducción y adducción, realizada en estudios previos del autor, permitió apreciar la aparición de pérdida de contacto entre las superficies articulares mediales o laterales respectivamente. El presente artículo tuvo como objetivo rememorar dichos estudios y documentar las apreciaciones visuales mediante el análisis de neumoartrografías seriada...

  16. Actividad inflamatoria en múltiples placas ateroscleróticas en pacientes fallecidos por infarto agudo de miocardio

    Directory of Open Access Journals (Sweden)

    Alejandro García Escudero

    2009-01-01

    Full Text Available IntroducciónEstudios clínicos y anatomopatológicos sugieren que los procesos inflamatorios tienen un papel importante en la inestabilidad de la placa aterosclerótica, dado que en pacientes con síndromes coronarios agudos se observan infiltrados inflamatorios difusos en las arterias coronarias.ObjetivosEvaluar y localizar la distribución de placas vulnerables e infiltrados inflamatorios en pacientes fallecidos por infarto agudo de miocardio.Material y métodosMediante microscopia óptica se estudiaron las arterias coronarias de 58 pacientes fallecidos por infarto de miocardio. En las arterias coronarias relacionadas con el infarto y en las no relacionadas se registraron las siguientes variables: presencia de trombo, rotura de placa, hemorragia intraplaca y presencia de infiltrado inflamatorio.ResultadosAl analizar las diferencias existentes entre las arterias responsables del infarto y en las no responsables se encontraron diferencias significativas con respecto a la presencia de trombo (69% versus 38%; p < 0,008 y de hemorragia intraplaca (69% versus 50%; p < 0,03. No se encontró una diferencia significativa entre la arteria responsable y la no responsable al evaluar la presencia de infiltrado inflamatorio en las placas ateroscleróticas (77% versus 71%; p = ns.ConclusiónEn el infarto agudo de miocardio se comprobó la presencia de actividad inflamatoria que afectaba a más de un vaso, con compromiso de otras arterias además de la responsable del infarto. Se detectó también accidente agudo de placa en más de una arteria coronaria.REV ARGENT CARDIOL 2009;77:81-87.

  17. Comparación de los efectos de dos técnicas de electroanalgesia en la enfermedad articular degenerativa tarsometatarsiana del equino Comparison between the effects of two electroanalgesical technics in the tarsometatarsal degenerative joint disease

    Directory of Open Access Journals (Sweden)

    J.A. García Liñeiro

    2006-12-01

    Full Text Available Se realizó una experiencia para comparar los resultados analgésicos entre TENS (cuyas siglas derivan de la expresión en inglés: transcutaneus electrical neuromuscular stimulation y el EMAR (estimulación mecánica por acción refleja de efectividad comprobada en medicina equina, sobre un modelo clínico de 10 equinos afectados por enfermedad articular degenerativa tarsometatarsiana con un protocolo diagnóstico estandarizado. Sobre la misma población se hicieron los dos tratamientos con intervalos de 6 meses entre uno y otro comparándose luego los resultados. Las aplicaciones en cada tratamiento fueron diarias y el control clínico se realizó post-tratamientos cada dos días (5 controles totales por los mismos tres profesionales para mantener el mismo esquema de evaluación, considerándose como parámetros: a- Trote en línea recta y en círculo, terreno blando y duro b­Flexión forzada c- Test del tarso (test de Churchill. Se realizó la prueba de Mc Nemar para comparar los grados de claudicación y respuestas a la flexión forzada, observados durante el 5to control, obtenidos luego de aplicar EMAR y TENS, y no se encontraron diferencias significativas entre ambos tratamientos (p=0,2568. También, se comparó el resultado del Test del Tarso (Test de Churchill luego de aplicar EMAR y TENS, con la prueba de Mc Nemar, no encontrándose diferencias significativas entre ambos (p= 0,7055. Se determina que hay muy poca diferencia entre ambos tratamientos fisioterápicos, observándose una disminución importante a partir del control 2. De estos resultados podemos inferir que ambos métodos pueden utilizarse con éxito en forma indistinta, seleccionándolos de acuerdo con las ventajas y desventajas de su aplicación.A clinical model was designed in order to compare the analgesic effects of TENS (transcutaneous electrical neuromuscular stimulation and RAME (reflex action mechanical electrostimulation, since both methods have been proven

  18. Detección de glicosaminoglicanos de la matriz del cartílago articular en el líquido sinovial de carpo equino con fractura en esquirla Detection of glycosaminoglycans of the articular cartilage matrix in the synovial fluid of equine carpal joint with chip fracture

    Directory of Open Access Journals (Sweden)

    H Adarmes

    2008-01-01

    Full Text Available El objetivo de este estudio fue determinar si la duración de la fractura en esquirla de carpo en equinos Fina Sangre de Carrera afecta la concentración sinovial de glicosaminoglicanos totales (GAGsT y de una fracción de éstos, que corresponde a los GAGs diferentes del ácido hialurónico o GAGs sulfatados (GAGsS. Se analizaron dos grupos de equinos con fractura en esquirla de distinta duración: uno con un período menor a los 30 días desde el diagnóstico hasta la artrocéntesis (grupo I (n = 14 y otro, con un período igual o mayor a los 60 días (grupo II (n = 14, y como grupo control se obtuvo líquido sinovial de articulaciones de carpo sanas al examen visual post mortem, de equinos de matadero luego del sacrificio (n = 14. La concentración de proteínas, GAGsT y GAGsS en el líquido sinovial se realizó espectrofotométricamente. La concentración de proteínas fue significativamente mayor (P The purpose of this study was to establish if the duration of chip fracture in equine carpal joint of purebred horses, affects the synovial concentration of total glycosaminoglycans (GAGsT and glycosaminoglycans that are different from hyaluronic acid or sulfated GAGs (GAGsS. Two groups of horses with different duration of fracture period were analyzed: one group (group I with a period of less than 30 days from carpal fracture diagnosis to arthrocentesis (n=14, and another group (group II with a period similar or longer than 60 days (n=14. Normal synovial fluid was collected from healthy carpal joints of crossbred horses immediately after slaughter (n=14, without any major damage at post mortem examination. The synovial fluid concentration of protein and GAGs was determined spectrophotometrically. Protein concentration showed a significant increase (P 0.05 between control group (0.19 ± 0.12 g/L and both fracture groups (0.15 ± 0.09 g/L (group I and 0.17 ± 0.17 g/L (group II. The concentration of hyaluronic acid, obtained by the difference

  19. Revisión de la casuística neurológica de naturaleza inflamatoria reportada en equinos durante los años 2005 a 2009 en el Laboratorio de Diagnóstico del Instituto Colombiano Agropecuario (ICA) / Histologic review of cases with neurological siymtoms in horses reported at the Instituto Colombiano Agropecuario (ica) Bogota during 2005 to 2009

    OpenAIRE

    Urrea Quiroga, Martha Isabel

    2012-01-01

    Como parte de la práctica de interés académico, en este trabajo se realizó una revisión y profundización histopatológica de las lesiones de cada una de las enfermedades de tipo inflamatorio del SNC, diagnosticadas en el ICA sede Bogotá, entre los años 2005 a 2009 en la especie equina. Durante el periodo de tiempo predeterminado, se remitieron al laboratorio 115 casos (cadáveres o tejidos) de equinos que presentaron, según la historia de remisión, sintomatología nerviosa; de estos casos, no se...

  20. Citocinas anti-inflamatorias y sus acciones y efectos en la sepsis y el choque séptico - Anti-inflammatory cytokines and their actions and effects in the sepsis and septic shock

    Directory of Open Access Journals (Sweden)

    González Álvarez, Ricardo

    2009-09-01

    Full Text Available ResumenLas citocinas anti- inflamatorias reconocidas son las interleucinas (ILIL-4, IL-10, IL-6, IL-13, el factor estimulante de colonia granulocito – macrófago (FEC-GM y el interferón alfa (IFN-alfa, los cuales tienen la capacidad de inhibir la liberación de las citocinas pro-inflamatorias y de inducir la producción del antagonista del receptor de la IL-1 y la liberación del receptor soluble del FNT, los cuales limitan algunas de las actividades de las citocinas pro-inflamatorias IL-1 y FNT-α. Sin embargo, los eventos que ocurren durante la inflamación y la sepsis no son tan simples como para justificar siempre acciones antagonistas entre las citocinas pro-inflamatorias y las antiinflamatorias, las cuales, pueden tener acorde con las circunstancias un comportamiento dual y/o antagónico en el choque séptico. Así por ejemplo la IL-10 tiene propiedades anti-inflamatorias, lo cual ocurre en la diabetes auto-inmune cuyo comienzo y desarrollo son acelerados en ratones transgénicos que sobre-expresan la IL-10 en los islotes pancreáticos. Esto también ocurre con la IL-10 en un modelo de uveítis en el que se incrementó la inflamación ocular. Ejemplos como los anteriores son extensivos a otras citocinas antiinflamatorias como la IL-4, IL-13, el factor estimulante de colonia granulocito –macrófago y el factor beta transformante del crecimiento (FβTC, y que serán mencionadas y descritas en el presente artículo de revisión, así como los factores que determinan ese comportamiento dual de las citocinas.SummaryThe anti-inflammatory cytokines which are recognized are theinterleukins (IL IL-4, IL-10, IL-13, interferon-alpha (IFN-α andbecause they are able to inhibit the release of pro inflammatorycytokines, to induce the production of IL-1 receptor antagonist (IL-raand the release of soluble TNF receptor and to limit some of the proinflammatory activities of IL-1 and TNF. However the events whichoccur during inflammation and sepsis are

  1. Enfermedad Inflamatoria Intestinal. Un caso clínico

    Directory of Open Access Journals (Sweden)

    Rubén M. Gatti

    2005-04-01

    Full Text Available e presenta a la consulta un felino tipo Europeo de pelo largo de 6 años de edad, y con un peso histórico de 6,200 kg en condiciones normales, vive en un departamento con otro gato, no sale a la calle y come alimento balanceado comercial de bajas calorías tipo premiun. Tiene una historia previa de vómitos intermitentes que se acentuaron en los últimos meses a pesar de utilizar mediación sintomática como metoclopramida, ranitidina y sucralfato.Además de los vómitos, hay hiporexia y se observa en la consulta un peso de 4,500 kg. A la palpación del abdomen se sienten algunas asas intestinales engrosadas, por lo cual se indica hacer una ecografía, análisis de materia fecal conservada con formol y tres muestras en fresco (para buscar giardias y criptosporidium y una rutina de sangre, cuyos resultados se dan a continuación:Los análisis de materia fecal fueron ambos negativos.

  2. La reacción inflamatoria en la fisiopatogenia de la obesidad

    OpenAIRE

    Ma Victoria Domínguez García; Gerardo Gabriel Huitrón Bravo; Anaí A. Mendoza López

    2012-01-01

    La obesidad se caracteriza por inflamación crónica. Entre los biomarcadores de inflamación encontramos las citocinas producidas por los adipocitos y los macrófagos: TNF - a, IL - 6, leptina, adiponectina y resistina. La relación adipocito-macrófago impacta la respuesta inflamatoria observada en la obesidad, la cual tiene una relación directa con la cantidad de macrófagos acumulados en el tejido adiposo blanco, que contribuye a la producción de mediadores de la inflamación. En este documento s...

  3. Miopatía inflamatoria con compromiso inicial de músculos respiratorios y artritis reumatoidea

    OpenAIRE

    Martín Hunter; Irene Telias; Victoria Collado; Judith Sarano; Clarisa Álvarez; Juan Pablo Suárez

    2014-01-01

    Las miopatías inflamatorias constituyen un grupo heterogéneo de enfermedades musculares adquiridas de presentación subaguda, crónica y a veces aguda. Las entidades clínicas más frecuentes son la dermatomiositis, la polimiositis, la miositis necrotizante autoinmune y la miositis por cuerpos de inclusión. Suelen presentarse con debilidad muscular con predominio proximal y simétrica, pero rara vez comprometen los músculos respiratorios. Presentamos el caso de una mujer de 39 años con miopatía in...

  4. Fracture of articular cartilage.

    Science.gov (United States)

    Chin-Purcell, M V; Lewis, J L

    1996-11-01

    Crack formation and propagation is a significant element of the degeneration process in articular cartilage. In order to understand this process, and separate the relative importance of structural overload and material failure, methods for measuring the fracture toughness of cartilage are needed. In this paper, two such methods are described and used to measure fracture properties of cartilage from the canine patella. A modified single edge notch (MSEN) specimen was used to measure J, and a trouser tear test was used to measure T, both measures of fracture toughness with units of kN/m. A pseudo-elastic modulus was also obtained from the MSEN test. Several potential error sources were examined, and results for the MSEN test compared with another method for measuring the fracture parameter for urethane rubber. Good agreement was found. The two test methods were used to measure properties of cartilage from the patellae of 12 canines: 4-9 specimens from each of 12 patellae, with 5 right-left pairs were tested. Values of J ranged from 0.14-1.2 kN/m. J values correlated with T and were an average of 1.7 times larger than T. A variety of failure responses was seen in the MSEN tests, consequently a grade of 0 to 3 was assigned to each test, where 0 represented a brittle-like crack with minimal opening and 3 represented plastic flow with no crack formation. The initial cracks in 12/82 specimens did not propagate and were assigned to grade 3. The method for reducing data in the MSEN test assumed pseudo-elastic response and could not be used for the grade 3 specimens. Stiffness did not correlate with J. Neither J nor T was statistically different between right-left pairs, but varied between animals. The test methods appear useful for providing a quantitative measure of fracture toughness for cartilage and other soft materials. PMID:8950659

  5. Tratamiento del paciente con artrosis

    OpenAIRE

    Francisco Vargas Negrín; María D. Medina Abellán; Juan Carlos Hermosa Hernán; Ricardo de Felipe Medina

    2014-01-01

    El manejo terapéutico del paciente con artrosis tiene como objetivo disminuir la sintomatología dolorosa e inflamatoria, mejorar la capacidad funcional del paciente y la aplicación de intervenciones terapéuticas eficaces y lo más seguras posibles. Un enfoque centrado en el paciente implica su participación activa en el diseño del plan terapéutico y en la toma de decisiones informadas oportunas en todas las etapas de la enfermedad. La educación terapéutica, la actividad física y el ejercicio t...

  6. Miopatía inflamatoria con compromiso inicial de músculos respiratorios y artritis reumatoidea

    Directory of Open Access Journals (Sweden)

    Martín Hunter

    2014-10-01

    Full Text Available Las miopatías inflamatorias constituyen un grupo heterogéneo de enfermedades musculares adquiridas de presentación subaguda, crónica y a veces aguda. Las entidades clínicas más frecuentes son la dermatomiositis, la polimiositis, la miositis necrotizante autoinmune y la miositis por cuerpos de inclusión. Suelen presentarse con debilidad muscular con predominio proximal y simétrica, pero rara vez comprometen los músculos respiratorios. Presentamos el caso de una mujer de 39 años con miopatía inflamatoria inespecífica que presentó insuficiencia respiratoria secundaria a hipoventilación alveolar por debilidad muscular y requirió asistencia respiratoria mecánica. Respondió favorablemente y de forma rápida tras el tratamiento instaurado con inmunosupresores (corticoides y metotrexato e inmunoglobulina humana endovenosa. Se utilizó ventilación no invasiva como alternativa a la intubación orotraqueal con adecuada tolerancia.

  7. DIFFERENTIAL DIAGNOSIS OF ARTICULAR SYNDROME IN PSORIASIS

    OpenAIRE

    VAISOV ADKHAM SHAVKATOVICH; ALLAEVA MUASSAR JALALADINOVNA

    2015-01-01

    Articular syndrome in psoriasis is an urgent problem to date. By the way, not always articular syndrome in psoriasis is a manifestation of the disease. And so, below is a case osteochondropathy patient with psoriasis.

  8. Development of artificial articular cartilage.

    Science.gov (United States)

    Oka, M; Ushio, K; Kumar, P; Ikeuchi, K; Hyon, S H; Nakamura, T; Fujita, H

    2000-01-01

    Attempts have been made to develop an artificial articular cartilage on the basis of a new viewpoint of joint biomechanics in which the lubrication and load-bearing mechanisms of natural and artificial joints are compared. Polyvinyl alcohol hydrogel (PVA-H), 'a rubber-like gel', was investigated as an artificial articular cartilage and the mechanical properties of this gel were improved through a new synthetic process. In this article the biocompatibility and various mechanical properties of the new improved PVA-H is reported from the perspective of its usefulness as an artificial articular cartilage. As regards lubrication, the changes in thickness and fluid pressure of the gap formed between a glass plate and the specimen under loading were measured and it was found that PVA-H had a thicker fluid film under higher pressures than polyethylene (PE) did. The momentary stress transmitted through the specimen revealed that PVA-H had a lower peak stress and a longer duration of sustained stress than PE, suggesting a better damping effect. The wear factor of PVA-H was approximately five times that of PE. Histological studies of the articular cartilage and synovial membranes around PVA-H implanted for 8-52 weeks showed neither inflammation nor degenerative changes. The artificial articular cartilage made from PVA-H could be attached to the underlying bone using a composite osteochondral device made from titanium fibre mesh. In the second phase of this work, the damage to the tibial articular surface after replacement of the femoral surface in dogs was studied. Pairs of implants made of alumina, titanium or PVA-H on titanium fibre mesh were inserted into the femoral condyles. The two hard materials caused marked pathological changes in the articular cartilage and menisci, but the hydrogel composite replacement caused minimal damage. The composite osteochondral device became rapidly attached to host bone by ingrowth into the supporting mesh. The clinical implications of

  9. Acil coenzima-a sintetasas de cadena larga (acsls) como biomarcadores citoserológicos en enfermedades inflamatorias o autoinmunes

    OpenAIRE

    Matesanz, F; Fedetz, María; Ndagire, D.; Alcina, Antonio; Sabio, José Mario

    2010-01-01

    [ES] Uso de las Acil-Coenzima-A sintetasas de cadena larga (ACSL) como biomarcadores cito-serológicos de enfennedades inflamatorias o autoinmunes, y especialmente de lupus eritematoso sistémico, y método de obtención de datos útiles para el diagnóstico y seguimiento de dichas enfennedades.

  10. La peroxidación lipídica en la etiopatogenia de la enfermedad periodontal inflamatoria

    Directory of Open Access Journals (Sweden)

    Bárbara E García Triana

    1998-04-01

    Full Text Available Las especies reactivas del oxígeno están implicadas en la etiopatogenia de la inflamación. Durante la activación de los leucocitos, se liberan grandes cantidades de estas especies, cuya función es la eliminación de los agentes patógenos. Si las defensas antioxidantes de los tejidos no funcionan eficientemente, son inducidas reacciones radicálicas que afectan a las biomoléculas. El ataque a los lípidos de la membrana celular provoca su peroxidación, con la consiguiente formación de nuevas especies radicálicas y metabolitos tóxicos. La presencia de un fuerte infiltrado inflamatorio en los tejidos periodontales, durante la enfermedad periodontal inflamatoria, ha sugerido la posible participación de las especies reactivas del oxígeno en la etiopatogenia de esta enfermedad. Se supone que el ataque de estas sustancias a los tejidos periodontales con deficiente defensa antioxidante, provoca la aparición de la peroxidación lipídica, que puede conducir a la lisis celular y la activación de proteasas.The reative oxygen species are involved in the pathogenesis of inflammation. Leukocyte activation released a great amount of these species the function of which is to eliminate pathogen agents. If antioxidant tissue defenses do not act properly, then radical reactions affecting biomolecules are induced. The attack on cell membrane lipids caused their peroxidation followed by the formation of new radical species and toxic metabolites. The existence of a strong inflammatory infiltrate in periodontal tissues in the course of the periodontal disease suggest the possible involvement of reactive oxygen species in the pathogenesis of this disease. It is supposed that the attack of these substances on the poorly antioxidant defended periodontal tissues makes the lipid peroxidation take place, which may lead to cellular lysis and proteases activation.

  11. Postnatal development of articular cartilage

    NARCIS (Netherlands)

    Turnhout, van M.C.

    2010-01-01

    Articular cartilage (AC) is the thin layer of tissue that covers the ends of the bones in the synovial joints in mammals. Functional adult AC has depth-dependent mechanical properties that are not yet present at birth. These depth-dependent mechanical properties in adult life are the result of a dep

  12. Propioceptores articulares y musculares

    OpenAIRE

    Vega, José A.

    1999-01-01

    La función de los mecanorreceptores de las articulaciones y músculos se considera asociada a la propiocepción. Sin embargo, existen evidencias de que la propiocepción no sólo depende del morfotipo de mecanorreceptor presente en dichos tejidos sino también de las propiedades de las neuronas sensitivas primarias y las fibras sensitivas asociadas a ellos, así como de su proyección sobre el asta posterior de la médula espinal. Este artículo resume las bases morfológicas de la propi...

  13. Incidencia de la cervicalgia de origen no articular en las actividades de la vida diaria.

    OpenAIRE

    Prioletto, Matías

    2010-01-01

    El presente trabajo de investigación se refiere a la “Incidencia de la cervicalgia de origen no articular en las actividades de la vida diaria”. La cervicalgia de origen no articular es una manifestación de dolor en las partes posterior y posteroloaterales del cuello, con o sin irradiación a las zonas y segmentos adyacentes, que encuentra su origen en las alteraciones de las partes blandas extraarticulares del raquis cervical. Considerando las relaciones entre las diferente...

  14. Hidrogeles biodegradables para la regeneración de cartílago articular

    OpenAIRE

    CANTÓ LORAS, PETRA

    2015-01-01

    [CAT] El cartílag articular és un teixit connectiu molt especialitzat present a les articulacions, que actua com amortidor suportant enormes carregues y proporcionant una superfície de lliscament de baixa fricció. Les patologies del cartílag articular suposen la pèrdua de l’estructura i de la funció del teixit i són una de les principals causes de discapacitat en persones grans. Es tracta d’un teixit avascular que presenta una capacitat d’autoreparació limitada. S’han desenvolupat nombrosos p...

  15. Uso de concentrados autólogos de plaquetas intraarticulares como coadyuvantes en el tratamiento quirúrgico de la rotura del ligamento cruzado anterior en una perra Use of intra-articular autologous platelet concentrates as coadjutants in the surgical treatment of a cranial cruciate ligament rupture in a bitch

    Directory of Open Access Journals (Sweden)

    RF Silva

    2011-01-01

    Full Text Available La ruptura del ligamento cruzado anterior (RLCA es uno de los principales problemas ortopédicos que producen cojera de los miembros posteriores en perros. A pesar de que este problema sea tratado quirúrgicamente el desarrollo y progresión de la osteoartritis son típicamente característicos. Se describe un caso de un perro que recibió inyecciones intraarticulares de concentrados autólogos de plaquetas (APCs durante el posoperatorio después de la reparación quirúrgica de una RLCA. Los resultados clínicos y radiográficos y el análisis de la marcha mediante plataforma de fuerza podrían potencialmente soportar la utilización posoperatoria de inyecciones intraarticulares de APCs como terapia coadyuvante en el tratamiento quirúrgico de la RLCA en perros.Cranial cruciate ligament rupture (CCLR is one of the main orthopedic problems that could produce hind limb lameness in dogs. Even though this problem can be surgically treated the development and progression of osteoarthritis are typical features. A case of a dog that received postoperative intra-articular injections of autologous platelet concentrates (APCs after the surgical reparation of a CCLR is described. The clinical, radiographic, and gait analysis results could potentially support the postoperative use of intra-articular injections of APCs as an adjunctive therapy in the CCLR surgical reparation.

  16. La reacción inflamatoria en la fisiopatogenia de la obesidad

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    Ma. Victoria Domínguez García

    2012-01-01

    Full Text Available La obesidad se caracteriza por inflamación crónica. Entre los biomarcadores de inflamación encontramos las citocinas producidas por los adipocitos y los macrófagos: TNF - a, IL - 6, leptina, adiponectina y resistina. La relación adipocito-macrófago impacta la respuesta inflamatoria observada en la obesidad, la cual tiene una relación directa con la cantidad de macrófagos acumulados en el tejido adiposo blanco, que contribuye a la producción de mediadores de la inflamación. En este documento se hará una revisión de las principales moléculas involucradas en la generación de inflamación en la obesidad, y la relación entre macrófagos y adipocitos.

  17. Enfermedad inflamatoria pélvica tumoral en adolescentes Imflammatory pelvic tumoral disease in adolescents

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    Valentín Martínez Camilo

    2002-08-01

    Full Text Available Se realizó un estudio descriptivo, longitudinal y prospectivo en el hospital materno de Guanabacoa durante el período de 1995 al 2000 con el objetivo de estudiar el comportamiento de la enfermedad pélvica inflamatoria tumoral en las pacientes adolescentes. La muestra estuvo constituida por 40 pacientes que fueron atendidas en nuestro centro a las que se le realizó una encuesta de donde se obtuvieron los datos para el estudio. El antecedente de enfermedad pélvica inflamatoria, el DIU como método anticonceptivo y el aborto fueron los factores epidemiológicos más sobresalientes; de igual forma el dolor, fiebre, trastorno menstrual y leucocitosis, así como eritrosedimentación fueron los elementos clínicos más destacados. El tratamiento que más se realizó fue el médico y la obstrucción tubaria fue la secuela principal. Se concluyó que el pronóstico es desfavorable para la fertilidad aún en los casos en el que el tratamiento médico fue eficaz.A descriptive, longitudinal and prospective study was conducted at the Maternal Hospital of Guanabacoa aimed at studying the behavior of the inflammatory pelvic tumoral disease in adolescent patients. The sample was composed of 40 patients that received attention in our center, where they were surveyed to obtain the data for the study. The history of inflammatory pelvic tumoral disease, the IUD as a contraceptive method and abortion were the most significant epidemiological factors. Likewise, pain, fever, menstrual disorder and leukocytosis as well as erythrosedimentation were the most remarkable clinical elements. The medical treatment was the most used and the tubal obstruction was the main sequela. It was concluded that the prognosis is unfavorable for fertility even in those cases whose medical treatment proved to be efficient.

  18. Arthoscopy La artroscopia y las lesiones articulares

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    Raúl J. Naranjo

    1991-01-01

    Full Text Available

    A general view is presented on arthroscopy; its history, indications and limitations are described and analyzed; its advantages in comparison with open surgery are emphasized.

    La artroscopia es un procedimiento que permite, mediante un instrumento óptico, evaluar el Interior de las cavidades articulares. Comenzó a desarrollarse como un procedimiento diagnóstico y pronto sus grandes ventajas frente a las exploraciones abiertas aceleraron el desarrollo de las técnicas y del instrumental. La minimización del trauma a los tejidos y la menor morbilidad posoperatoria permiten que la deambulación y la recuperación funcional sean precoces lo cual, sumado a un mejor resultado estético, ha colocado a la artroscopia como procedimiento de elección para el diagnóstico y el tratamiento de múltiples estados patológicos intraarticulares.

  19. Characterization of patient’s inflammatory pulpal diseases. Caracterización de pacientes con afecciones pulpares inflamatorias

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    Ana Isabel Palenque Guillemí

    2008-06-01

    Full Text Available Background: Pulpal diseases are the most common entities in the dentist emergency consultation. For a correct indication of the treatment, it is very important to establish an accurate diagnosis. Objective: to characterize carrier patients with inflammatory pulpal disease. Methods: a descriptive, prospective cases series study which included 222 patients who came to the dentistry emergency consultation in Area I health policlinic. Age, type of disease, cause, more implicated teeth in the disease, visits, and previous treatments were the variables included. Results: there was no difference at all regarding sex. The most affected group of age was from 35 to 59 years old. The inferior molars were the most affected teeth. The main cause was dental cavities. Obturation was the previous treatment more presented. 46% of the patients attended the dentist in more than one occasion with the same process. Acute irreversible pulpitis was the most predominant pulpal disease. Conclusions: The most common pulpal diseases in our milieu was the acute irreversible pulpitis among the ages 35 and 59 years old.
    Fundamento: Las afecciones pulpares son las enfermedades que más llevan a los pacientes a una consulta de urgencia estomatológica. En estos casos, para una correcta indicación de tratamiento, es de suma importancia el establecimiento de un diagnóstico preciso. Objetivo: Caracterizar pacientes portadores de afectaciones pulpares inflamatorias. Métodos: Estudio descriptivo, prospectivo de serie de casos que incluyó 222 pacientes que asistieron a consulta de urgencia estomatológica en la policlínica del Área 1. Se incluyeron las siguientes variables: edad, tipo de afectación, causa, dientes más afectados, visitas y tratamientos previos. Resultados: No hubo diferencias en cuanto al sexo, el

  20. Estudio Transversal sobre la Relación entre Neuroticismo y Curso Clínico en Pacientes con Enfermedades Inflamatorias Intestinales

    OpenAIRE

    Juan Carlos Fernández Méndez; José Andrés Pérez Vidal; Berta Fernández Méndez

    2010-01-01

    En el presente trabajo se analiza la relación que existe entre neuroticismo y diversas condiciones médicas que hacen referencia al curso clínico de las enfermedades inflamatorias intestinales. Para desarrollar la investigación se tomaron medidas en neuroticismo mediante el Inventario de Personalidad de Eysenck a 106 participantes diagnosticados de colitis ulcerosa y enfermedad de Crohn. Los resultados reflejaron que la muestra global de pacientes con enfermedades inflamatorias intestinales mo...

  1. Tratamiento cognitivo-conductual protocolizado en grupo de las enfermedades inflamatorias intestinales Protocolized cognitive-behavioural group therapy for inflammatory bowel disease

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    M. A. Díaz Sibaja

    2007-10-01

    Full Text Available Introducción: los pacientes con enfermedades inflamatorias intestinales presentan una mayor tasa de alteraciones psicopatológicas que la población normal, predominantemente ansiedad y depresión. Objetivo: el principal objetivo de este estudio fue diseñar, poner en práctica y validar un programa de tratamiento psicológico protocolizado, basado en el modelo de competencias y con una metodología psicoeducativa, en el que se incluyeron los siguientes módulos de intervención: información de la enfermedad, modelo de afrontamiento, solución de problemas, técnicas de relajación, entrenamiento en habilidades sociales, técnicas de distracción y técnicas de reestructuración cognitiva. Todas estás técnicas fueron adaptadas a la problemática característica de la enfermedad inflamatoria intestinal. Método: la muestra estuvo constituida por 57 pacientes diagnosticados de enfermedad inflamatoria intestinal de la Asociación de Enfermos de Crohn y Colitis Ulcerosa de España. La muestra se distribuyó aleatoriamente en dos grupos experimentales, 33 formaron parte del programa de tratamiento en grupo y 24 fueron asignados al grupo control en lista de espera. Las variables emocionales medidas fueron: ansiedad y depresión. Resultados: los resultados reflejaron una mejoría clínica y estadísticamente significativa en las variables de ansiedad (p Introduction: patients affected by inflammatory bowel disease have a high rate of psychiatric disorders such as depression and anxiety. Objective: the main goal of this study was to design, to put into practice, and to validate a protocolized psychological treatment program based on the coping model, and a psycho-educational methodology in which the following intervention modules were included- illness information, coping model, problem solving techniques, relaxation, social skill training, distraction, and cognitive restructuring techniques. All these techniques were adapted to the characteristic

  2. Importancia de los lípidos en el tratamiento nutricional de las patologías de base inflamatoria Importance of lipids in the nutritional treatment of inflammatory diseases

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    M. D. Mesa García

    2006-05-01

    Full Text Available En las últimas décadas, el conocimiento acerca de las propiedades antiinflamatorias de los lípidos ha facilitado el desarrollo de productos adaptados a la nutrición enteral y parenteral que han sido utilizados como terapia en numerosas enfermedades de base inflamatoria. En esta revisión se ofrece una visión general de los efectos de los lípidos utilizados en nutrición enteral, sobre ciertas patologías en cuya base están implicados procesos inflamatorios, como es el caso de las enfermedades inflamatorias intestinales, la aterosclerosis, la fibrosis pulmonar y la artritis reumatoide, entre otras. Durante los procesos inflamatorios se producen mediadores químicos, como los eicosanoides, a partir de ácidos grasos poliinsaturados presentes en las membranas celulares. La actividad inflamatoria de estas moléculas depende del ácido graso precursor. Los derivados del ácido araquidónico (de la serie n-6 tienen una elevada actividad proinflamatoria, mientras que los derivados del eicosapentaenoico (de la serie n-3 son débilmente inflamatorios. Así, al ingerir aceites de pescado, ricos en ácidos grasos n-3, aumenta el contenido de eicosapentaenoico y disminuye el araquidónico en las células del sistema inmune, por lo que se reduce la estimulación inflamatoria debido a la presencia de mediadores menos activos. Éste parece ser el mecanismo inmunomodulador fundamental de las dietas ricas en n-3. Asimismo, pero mediante mecanismos de acción diferentes, se ha demostrado que el ácido oleico disminuye la intensidad de algunos procesos inflamatorios, al disminuir la producción de mediadores quimiotácticos de inflamación. Podemos concluir que la suplementación de dietas para nutrición enteral con ácidos grasos poliinsaturados n-3 y oleico resulta beneficiosa para el tratamiento de ciertas patologías donde los procesos inflamatorios participan activamente en su desarrollo, mejorando su evolución y disminuyendo las dosis de f

  3. Inestabilidad crónica de tobillo: tratamiento mediante movilizaciones articulares y un programa de entrenamiento propioceptivo. Validación de la versión española del cuestionario "Cumberland Ankle Instability Tool"

    OpenAIRE

    Cruz-Díaz, David

    2013-01-01

    [ES] La inestabilidad crónica de tobillo CAI es una patología muy frecuente debido a que hasta un 80% de todos los pacientes que sufren un esguince de tobillo desarrollan secuelas relacionadas con la inestabilidad mecánica y funcional. Basándonos en la fisioterapia basada en la evidencia, el tratamiento de esta patología mediante la aplicación de técnicas de movilización articular y entrenamiento propioceptivo parece ser el más acertado para mejorar los déficits funcionales de estos pacientes...

  4. Tratamiento farmacológico invasivo articular en la artrosis

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    D. Benítez Pareja

    2016-04-01

    Full Text Available La degeneración de las articulaciones axiales y periféricas va unida al propio envejecimiento del ser humano. Es responsable del dolor e impotencia funcional, y su fisiopatología es compleja y no del todo conocida. El denominador común en la artrosis es la degeneración del cartílago articular, junto a otras alteraciones secundarias. Su abordaje y manejo del dolor supone todo un reto para las Unidades del Dolor. Históricamente, el tratamiento intervencionista se llevó a cabo mediante infiltraciones a ciegas de diferentes sustancias que alivian el dolor. En la actualidad, la fluoroscopia, y más recientemente los ultrasonidos, son los métodos de elección para la guía de nuestros procedimientos. En cuanto a los fármacos utilizados más comúnmente en nuestras técnicas invasivas articulares destacaremos el ácido hialurónico (AH y el plasma rico en plaquetas (PRP. Los esteroides siguen siendo, en prácticamente todos los estudios, el estándar de oro o fármaco de referencia y sobre los que se comparan el resto de familias de fármacos. Una exploración exhaustiva del paciente, y un algoritmo de decisiones en cuanto a la decisión de realización de estas técnicas, se antoja necesario, adecuándose a cada lugar de trabajo.

  5. Alteraciones del compartimento epitelial del sistema inmune de la mucosa ocular en la queratoconjuntivitis vernal

    OpenAIRE

    Rubio Martínez, Soledad

    2013-01-01

    Cada vez son más los estudios que demuestran el papel del tejido linfoide asociado a la conjuntiva (CALT) en la regulación de la respuesta inmune de la superficie ocular. Nuestro grupo de investigación ya ha establecido un mapa topográfico del componente epitelial del CALT en adultos sanos y, además, en pacientes afectados por una enfermedad inflamatoria de la superficie ocular, el síndrome de ojo seco. Este trabajo preliminar pretende iniciar el mismo tipo de análisis en una enfermedad cl...

  6. Influencia del ambiente sobre la microbiota comensal del intestino de la rata: Implicaciones en la inflamación y en mecanismos sensoriales

    OpenAIRE

    Terán Ventura, Demetria Evangelina

    2009-01-01

    Evidencias recientes sugieren que la microbiota comensal del intestino constituye un factor dinámico que se relaciona activamente con el hospedador, mediante sistemas específicos de reconocimiento bacteriano, y participa en la regulación de funciones sensoriales, motoras y secretoras gastrointestinales. En particular, la microbiota comensal del intestino se ha implicado en los mecanismos fisiopatológicos de la enfermedad inflamatoria intestinal. Este trabajo de investigación tiene como objeti...

  7. Efectos de la suplementación con membrana de cáscara de huevo sobre alteraciones tendinopáticas, articulares y variables mecánicas del tendón de Aquiles en deportistas de crossfit.

    OpenAIRE

    Jauregui Bidegain, Lucas

    2016-01-01

    Introducción: En la patología del tendón de aquiles es determinante el análisis de los factores mecánicos que ayudan a explicar el comportamiento del tendón, siendo de los más estudiados el stiffness lineal. No existe actualmente evidencia acerca de los efectos de la suplementación con membrana de cáscara de huevo en el stiffness. Únicamente se ha examinado mediante escalas de valoración subjetiva, por lo que la medición mediante ecografía del stiffness tendinoso como variable direc...

  8. Asma bronquial. Estado del arte.

    OpenAIRE

    Jorge Salazar

    2009-01-01

    Para infinidad de personas el asma es su problema de salud. El diagnóstico y el tratamiento varían dependiendo de la magnitud del compromiso y la causa que produce la reacción inflamatoria en los pulmones. La prevención y el tratamiento serán mejores si la población y los pacientes reconocen la necesidad de evitar determinadas exposiciones ambientales y el uso de medicamentos con la frecuencia necesaria. Ahora los médicos generales conocen mejor la fisiología y patología de esta enfermedad y ...

  9. Impacto de la fatiga en la percepción de salud en la enfermedad inflamatoria intestinal.

    OpenAIRE

    Castillo Cejas, María Dolores; Casellas Jordà, Francesc

    2011-01-01

    La salud de los pacientes con enfermedad inflamatoria intestinal (EII) está afectada por la fatiga, que condiciona una baja calidad de vida. Este estudio administró cuestionarios de calidad de vida y fatiga a 110 pacientes con EII, cuantificando fatiga y correlacionándola con la actividad, se determinó la afectación de la calidad de vida. Los resultados mostraron relación inversa entre fatiga y actividad de EII, con diferencias estadísticamente significativas según brote o remisión de la enfe...

  10. Análisis y aplicación de estrategias para modular la respuesta inflamatoria en patologías intestinales

    OpenAIRE

    Orsini Delgado, María Lucía

    2016-01-01

    Durante las últimas décadas se ha reportado un importante incremento en la incidencia de patologías inmunes inflamatorias, no infecciosas, fundamentalmente en países desarrollados o en vías de desarrollo. Debido a la velocidad con que se ha incrementado la incidencia de estas patologías, sólo los cambios en los factores ambientales son capaces de explicarlo. Estudios epidemiológicos han permitido observar una asociación entre el incremento en patologías inflamatorias no infecciosas y la dismi...

  11. La modulación de sentencias como medio para articular la oportunidad política de la Corte Constitucional colombiana. El caso de las parejas del mismo sexo

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    Juan Pablo Sarmiento E.

    2012-01-01

    Full Text Available En el marco de la trasformación que ha sufrido el régimen de derecho de familia hacia la inclusión de parejas del mismo sexo, la Corte Constitucional ha jugado un papel central y quizá solitario. En este artículo se analizan los principales fallos de la Corte Constitucional relativos a la unificación en el ámbito de protección a las parejas del mismo sexo, extrayendo de cada uno de ellos los elementos de creación jurisprudencial más relevantes. Con lo anterior se argumentará, entonces, que por medio de diversos instrumentos interpretativos, la Corte ha instrumentalizado sus fallos para ejercer su oportunidad política en dirección a la opinión prevalente por medio del condicionamiento de las sentencias de constitucionalidad.

  12. Characterization of cutaneous and articular sensory neurons

    OpenAIRE

    da Silva Serra, I.; Husson, Z.; Bartlett, J.D.; Smith, E.S.J.

    2016-01-01

    Background A wide range of stimuli can activate sensory neurons and neurons innervating specific tissues often have distinct properties. Here, we used retrograde tracing to identify sensory neurons innervating the hind paw skin (cutaneous) and ankle/knee joints (articular), and combined immunohistochemistry and electrophysiology analysis to determine the neurochemical phenotype of cutaneous and articular neurons, as well as their electrical and chemical excitability. Results Immunohistoche...

  13. Fisiopatología celular de la osteoartritis: el condrocito articular como protagonista = Osteoarthritis cellular pathophysiology: The articular chondrocyte as a central player

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    Sánchez Naranjo, Julio César; López Zapata, Diego Fernando

    2011-01-01

    La osteoartritis es una de las enfermedades más prevalentes y que más discapacidad produce en todo el mundo, lo que ocasiona costos altos para el paciente y la sociedad. En años recientes se ha venido obteniendo información importante sobre el funcionamiento normal del condrocito, la única célula presente en el cartílago articular y responsable de la síntesis de matriz extracelular. El condrocito responde a las condiciones fluctuantes del medio, generadas por los cambios de presión, modifican...

  14. Estudio PET/TC en patología inflamatoria-infecciosa PET/CT in infectious and inflammatory pathology

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    Cecilia Carrera

    2012-06-01

    Full Text Available Objetivo. Demostrar la utilidad del examen PET/TC en patología inflamatoria-infecciosa. Materiales y Métodos. Evaluación retrospectiva (enero de 2009 - mayo de 2011 de los exámenes de tomografía por Emisión de Positrones/ Tomografía Computada (PET/TC, realizados en nuestra institución con un equipo híbrido SIEMENS-BIOGRAPH 16 (Siemens, Erlangen, Alemania. Se seleccionaron 5 pacientes. Resultados. Caso 1: paciente de 68 años de edad con fiebre de 6 meses de duración, fatiga y pérdida de peso. El examen reumatológico demostró disminución en pulsos radiales sin otros síntomas asociados. La paciente fue sometida a biopsia de arteria temporal. Ésta confirmó una arteritis de la arteria temporal y el estudio PET/TC demostró hipermetabolismo en la aorta torácica y ramas principales. Caso 2: paciente de 85 años con fiebre de origen desconocido (FOD y sospecha de osteomielitis de cadera. En contraposición, el PET/TC demostró un foco ávido de celulitis glútea y neumopatía. Caso 3: paciente de 35 años con fiebre vespertina. El PET/TC mostró múltiples adenomegalias ávidas por fluorodexosiglucosa (FDG en mediastino, axilas y retroperitoneo, y compromiso difuso esplénico asociado a calcificaciones. Se confirmó infección por citomegalovirus por inmuno-globulina G y M. Caso 4: paciente de 39 años con infección por HIV que consultó por hipercalcemia. El PET/TC mostró implantes de silicona en glúteos con proceso inflamatorio ávido asociado. Se confirmó por la biopsia de uno de ellos. Caso 5: paciente de 45 años con historia de cáncer de mama en control presentó en los últimos estudios tomográficos aumento del tamaño de los ganglios supraclaviculares y mediastínicos, y compromiso esplénico multifocal difuso. Estos resultaron ávidos en el examen PET/TC. Se confirmó el diagnóstico de sarcoidosis por el estudio anatomopatológico de un ganglio supraclavicular. Conclusiones. El PET/TC es un método no invasivo de

  15. Hallazgo de una leucorrea vaginal de carácter no inflamatoria en hembras bovinas. I. Examen macroscópico y microscópico (Finding of a vaginal leucorrhea of non-inflammatory character in bovine females. I. Macroscopic and microscopic examination

    Directory of Open Access Journals (Sweden)

    Luis O. Alba Gómez; Guadalupe Hernández Breto.

    2005-07-01

    Full Text Available Con el objetivo de demostrar la existencia de una leucorrea vaginal no inflamatoria en hembras bovinas, se examinaron macroscópicamente los órganos genitales de 350 novillas y 800 vacas Cebú comercial y mestizas Holstein x Cebú sacrificadas en el matadero. Se colectaron secreciones leucorréicas en las vaginas o cuernos uterinos del 12 y 20% de las novillas y vacas respectivamente. Ninguno de los órganos genitales de estos animales mostraron signos de inflamación en sus mucosas. El examen histológico se realizó en 80 muestras de vagina y de cuernos uterinos leucorréicos y solamente el 6,3% de los cortes histológicos de vaginas y el 8,8% de los de úteros presentaron lesiones microscópicas leves. El pH vaginal promedió 6,85  0,2. No se encontraron diferencias en el espectro electroforético entre las secreciones mucosas y las leucorréicas. Tampoco se encontraron células inflamatorias en los frotis teñidos. Los resultados indican que las secreciones leucorréicas observadas no son verdaderos exudados, sino secreciones mucosas modificadas que no tienen un origen inflamatorio.

  16. Comportamiento de variables epidemiológicas en la neuropatía óptica inflamatoria infecciosa. Centro Oftalmológico de Holguín. 2009

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    Enma Estrella de la Torre-Rodríguez

    2012-01-01

    Full Text Available Abordó un estudio descriptivo del comportamiento de algunas variables epidemiológicas en un universo de 18 pacientes con neuropatía óptica inflamatoria en el Centro Oftalmológico de Holguín de enero a diciembre de 2009. La muestra estuvo representada por 12 pacientes con etiología infecciosa. El mayor número de pacientes se incluyó en el grupo de edad de 15 a 29 años. Las ocupaciones de riesgo más frecuentes fueron los estudiantes, las amas de casa y criadores de palomas. Los perros, gatos y cerdos fueron los animales más frecuentes en contacto con los casos. La etiología parasitaria representó el grupo más frecuente como causa de la neuropatía y el agente que predominó fue Bartonella henselae. Se recomendó realizar estudios que incluyan confirmación serológica y/o del agente causal en este grupo de enfermedades.

  17. Enfermedad inflamatoria intestinal en pacientes celíacos Inflammatory bowel disease in celiac patients

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    M. Masachs

    2007-08-01

    Full Text Available Introducción: se ha sugerido una potencial asociación entre la enfermedad celíaca y la enfermedad inflamatoria intestinal, que puede justificar que ambas enfermedades puedan presentarse en un mismo enfermo o en sus familiares de primer orden con mayor frecuencia de lo esperado. Objetivo: determinar la prevalencia de la enfermedad de Crohn y la colitis ulcerosa en los enfermos celíacos y en sus familiares. Método: estudio epidemiológico prospectivo transversal en un grupo de pacientes celíacos, sus familiares de primer grado y un grupo control de características epidemiológicas similares, constituido por familiares de pacientes que acuden al Servicio de Urgencias por un problema agudo. Para detectar la existencia de colitis ulcerosa y enfermedad de Crohn en los celíacos y sus familiares, se realizó una entrevista semiestructurada. Resultados: se han incluido 86 celíacos y 432 familiares, que se han comparado con 809 controles (129 pacientes con una enfermedad aguda y 680 familiares de primer grado suyos. Se han detectado 3 casos de enfermedad de Crohn en el grupo de los enfermos celíacos y 4 casos de enfermedad de Crohn en sus familiares. Sólo se ha detectado 1 caso de enfermedad de Crohn en el grupo control (p Introduction: a potential association between celic disease and inflammatory bowel disease hs been suggested, which may explain the fact that both disorders occasionally present in one patient or in his/her first-degree relatives more frequently than expected. Objective: to establish the prevalence of Crohn's disease and ulcerative colitis in celiac patients and their relatives. Method: a cross-sectional, prospective epidemiological study in a group of celiac patients, their first-degree relatives, and a control group with similar epidemiological characteristics including the relatives of patients presenting at the ER for acute conditions. A semistructured interview was used to identify the presence of Crohn's disease and

  18. Uso de anticuerpos contra proteínas extracelulares de bacterias de la microbiota intestinal como biomarcadores de Enfermedad Inflamatoria Intestinal

    OpenAIRE

    Hevia González, Arancha

    2012-01-01

    En este trabajo se pretende utilizar los niveles de anticuerpos dirigidos contra bacterias ingeridas con los alimentos, representantes de la microbiota intestinal, como posibles biomarcadores para uso en la Enfermedad Inflamatoria Intestinal con el fin de facilitar el desarrollo de mejores métodos de diagnóstico precoz.

  19. Acil Coenzima-A sintetasas de cadena larga (ACSLs) como biomarcadores cito-serológicos en enfermedades inflamatorias o autoinmunes

    OpenAIRE

    Matesanz, F; Fedetz, María; Ndagire, D.; Alcina, Antonio; Sabio, José Mario

    2010-01-01

    Uso de las Acil-Coenzima-A sintetasas de cadena larga (ACSL) como biomarcadores cito-serológicos de enfermedades inflamatorias o autoinmunes, y especialmente de lupus eritematoso sistémico, y método de obtención de datos útiles para el diagnóstico y seguimiento de dichas enfermedades. Venta

  20. Determinación de citoquinas en espondiloartropatías inflamatorias: valoración de la actividad clínico-biológica en la artropatía psoriásica

    OpenAIRE

    Turrión Nieves, Ana Isabel

    2015-01-01

    Las espondiloartritis o espondiloartropatías inflamatorias constituyen un grupo de enfermedades reumáticas inflamatorias que afectan fundamentalmente a la columna vertebral. De estas la espondilitis anquilosante (EAnq) y la artropatía psoriásica (Aps), son las afectaciones más frecuentes. Los niveles de citoquinas y/o reactantes de fase aguda son marcadores biológicos de actividad clínica inflamatoria. Por ello siendo estas moléculas cuantificables en el laboratorio, su determinación puntual ...

  1. Articular chondrocyte metabolism and osteoarthritis

    Energy Technology Data Exchange (ETDEWEB)

    Leipold, H.R.

    1989-01-01

    The three main objectives of this study were: (1) to determine if depletion of proteoglycans from the cartilage matrix that occurs during osteoarthritis causes a measurable increase of cartilage proteoglycan components in the synovial fluid and sera, (2) to observe what effect intracellular cAMP has on the expression of matrix components by chondrocytes, and (3) to determine if freshly isolated chondrocytes contain detectable levels of mRNA for fibronectin. Canine serum keratan sulfate and hyaluronate were measured to determine if there was an elevation of these serum glycosaminoglycans in a canine model of osteoarthritis. A single intra-articular injection of chymopapain into a shoulder joint increased serum keratan sulfate 10 fold and hyaluronate less than 2 fold in 24 hours. Keratan sulfate concentrations in synovial fluids of dogs about one year old were unrelated to the presence of spontaneous cartilage degeneration in the joints. High keratan sulfate in synovial fluids correlated with higher keratan sulfate in serum. The mean keratan sulfate concentration in sera of older dogs with osteoarthritis was 37% higher than disease-free controls, but the difference between the groups was not statistically significant. Treatment of chondrocytes with 0.5 millimolar (mM) dibutyryl cAMP (DBcAMP) caused the cells to adopt a more rounded morphology. There was no difference between the amount of proteins synthesized by cultures treated with DBcAMP and controls. The amount of fibronectin (FN) in the media of DBcAMP treated cultures detected by an ELISA was specifically reduced, and the amount of {sup 35}S-FN purified by gelatin affinity chromatography decreased. Moreover, the percentage of FN containing the extra domain. A sequence was reduced. Concomitant with the decrease in FN there was an increase in the concentration of keratan sulfate.

  2. Development of artificial articular cartilage

    Indian Academy of Sciences (India)

    Biswajit Bera

    2009-10-01

    The present study describes the development of artificial articular cartilage on the basis of mimicking structural gel properties and mechanical gel properties of natural articular cartilage. It is synthesized from PVA/Si nanocomposite containing 20% Tetra ethoxy silane (TEOS) by sol–gel method. Mechanical strength of Poly(vinyl alcohol), PVA is improved up to 35 MPa. Manufacturing method is adopted considering colloidal stability of nano silica particle in PVA sol at specific pH = 1. An adhesive is also prepared from PVA/Si nanocomposite containing 40% TEOS for firm attachment of artificial articular cartilage on underlying bone with high bond strength.

  3. Luxación intra-articular de rótula Intra-articular dislocation of patella

    Directory of Open Access Journals (Sweden)

    S. García-Mata

    2006-08-01

    Full Text Available Presentamos el caso de una paciente de 73 años de edad que, tras una caída accidental en las escaleras, sufrió una luxación intra-articular aguda de rótula de la rodilla izquierda. Esta luxación excepcional presentaba incarceración del polo proximal rotuliano en el surco intercondíleo femoral. Se realizó reducción bajo anestesia general debido al dolor y contractura muscular en los intentos de reducción sin anestesia. Realizamos revision quirúrgica que descartó lesiones asociadas del aparato extensor, partes blandas, estructuras articulares y osteofitos. Presentaba artrosis avanzada, sobre todo fémoro-patelar. Tras dos semanas de inmovilización reinició movilidad. No ha presentado recidiva u otro tipo de complicaciones.The case of a patient aged 73 years who, following an accidental fall on a staircase, suffered an acute intraarticular dislocation in the left knee-cap is presented. This exceptional dislocation presented incarceration of the proximal kneecap pole in the femoral intercondylar groove. A reduction was carried out under general anaesthetic due to pain and muscular contraction in the attempts at reduction without anaesthetic. We made a surgical check that ruled out associated lesions to the extensor apparatus, soft parts, joint structures and osteophytes. The patient presented advanced arthrosis, above all femoral-patellar. Following two weeks of immobilisation, the patient restarted mobility. There has been no relapse or other type of complication.

  4. Avaliação do impacto da aplicação de manobra de hiperinsuflação pulmonar sobre a resposta inflamatória sistêmica e colapso pulmonar em pacientes submetidos a procedimentos cirúrgicos sob ventilação espontânea Evaluación del impacto de la aplicación de maniobra de hiperinsuflación pulmonar sobre la respuesta inflamatoria sistémica y colapso pulmonar en pacientes sometidos a procedimientos quirúrgicos bajo ventilación espontánea Assessing the impact of lung hyperinflation maneuver on systemic inflammatory response and lung collapse in patients undergoing surgeries under spontaneous ventilation

    Directory of Open Access Journals (Sweden)

    Luiz Marcelo Sá Malbouisson

    2010-06-01

    puede conllevar a una respuesta inflamatoria sistémica de origen pulmonar. Los objetivos de este estudio fueron comprobar el impacto de la aplicación de MHP sobre la respuesta inflamatoria sistémica y sobre la estructura pulmonar en pacientes sometidos a la anestesia subaracnoidea. MÉTODO: Después de la aprobación del Comité de Ética institucional y de la obtención del consentimiento informado, 20 pacientes sometidos a procedimientos quirúrgicos de pequeño y mediano porte, se separaron aleatoriamente en dos grupos: 1 control (GC y 2 MHP (GMHP. Una hora después de la instalación del bloqueo espinal, fue realizada MHP en el GMHP aplicando una presión positiva en las vías aéreas en los niveles (BIPAP con una presión espiratoria de 20 cmH2O y una presión inspiratoria de 20 cmH2O durante 1 a 2 minutos. FNTα, IL-1, IL-6, IL-8, IL-10 y IL-12 se midieron en la sangre a través de la técnica de citometría de flujo en los momentos basal, 90, 180 y 780 minutos. Los volúmenes y el peso pulmonares fueron computados a partir de tomografías computadorizadas obtenidas inmediatamente después de la operación. RESULTADOS: La aplicación de MHP resultó en una reducción de la fracción del parénquima pulmonar no aerado (7,5 ± 4,3% en el Grupo Control vs 4 ± 2,1% en el Grupo MHP, p = 0,02, sin alteraciones en los volúmenes pulmonares. Se observó una elevación progresiva en los valores plasmáticos de las interleucinas IL-1, IL-6, IL-8 y IL-10, similar en los dos grupos. Los niveles plasmáticos de FNTBACKGROUND AND OBJECTIVES: Lung hyperinflation maneuvers (LHM reverse intraoperative atelectasis; however, they can lead to pulmonary-induced systemic inflammatory response. The objective of this study was to determine the impact of LHM on systemic inflammatory response and lung structure in patients undergoing subarachnoid block. METHODS: After approval by the Ethics Committee of the institution and signing the informed consent, 20 patients undergoing small and

  5. Juxta-articular myxoma of the palm

    OpenAIRE

    Irving, AK; Gwynne-Jones, D; Osipov, V.; Nicholson, ML

    2012-01-01

    We present a case of juxta-articular myxoma of the hand in a 63-year-old man with an enlarging mass over the palmar radial aspect of the index metacarpophalangeal joint. Usually seen in men, this benign soft tissue tumour is normally found around large joints. To our knowledge this is the first reported case in the hand.

  6. Advanced Strategies for Articular Cartilage Defect Repair

    Directory of Open Access Journals (Sweden)

    Fergal J. O'Brien

    2013-02-01

    Full Text Available Articular cartilage is a unique tissue owing to its ability to withstand repetitive compressive stress throughout an individual’s lifetime. However, its major limitation is the inability to heal even the most minor injuries. There still remains an inherent lack of strategies that stimulate hyaline-like articular cartilage growth with appropriate functional properties. Recent scientific advances in tissue engineering have made significant steps towards development of constructs for articular cartilage repair. In particular, research has shown the potential of biomaterial physico-chemical properties significantly influencing the proliferation, differentiation and matrix deposition by progenitor cells. Accordingly, this highlights the potential of using such properties to direct the lineage towards which such cells follow. Moreover, the use of soluble growth factors to enhance the bioactivity and regenerative capacity of biomaterials has recently been adopted by researchers in the field of tissue engineering. In addition, gene therapy is a growing area that has found noteworthy use in tissue engineering partly due to the potential to overcome some drawbacks associated with current growth factor delivery systems. In this context, such advanced strategies in biomaterial science, cell-based and growth factor-based therapies that have been employed in the restoration and repair of damaged articular cartilage will be the focus of this review article.

  7. Impacto de la nutrición en la evolución de la enfermedad inflamatoria intestinal Impact of nutritional treatment in the evolution of inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    M.ª D. Ballesteros Pomar

    2010-04-01

    Full Text Available La enfermedad inflamatoria intestinal es una entidad de etiopatogenia aún no bien conocida, con importantes implicaciones nutricionales y metabólicas, por la alta prevalencia de malnutrición que conlleva; por la posible implicación de factores dietéticos en su patogenia; y por la hipótesis de que la intervención nutricional pudiera ser un tratamiento primario de la enfermedad. Algunos nutrientes, además de su función exclusivamente nutricional, podrían inducir un bajo estímulo antigénico, regular respuestas inflamatorias e inmunológicas y estimular el trofismo de la mucosa intestinal. La evidencia disponible actual apoya el empleo de nutrición enteral en enfermedad de Crohn como terapia primaria en adultos si el tratamiento con corticoides no es posible (fracaso o contraindicación (grado de recomendación A o bien en terapia combinada con fármacos en pacientes malnutridos y estenosis inflamatoria del intestino. En los pacientes en remisión clínica duradera no se ha demostrado beneficio de la nutrición enteral o suplementos en ausencia de déficits nutricionales. No se recomienda el uso de fórmulas elementales ni modificadas (glutamina, ácidos grasos omega 3. En colitis ulcerosa, no se ha demostrado la influencia de la nutrición sobre la actividad de la enfermedad, aunque disponemos de datos prometedores sobre el papel de los ácidos grasos w3 con cubierta entérica y de un posible papel de los probióticos. En el tratamiento y profilaxis de la pouchitis crónica, el empleo de probióticos puede tener un papel (VSL#3. La nutrición debe considerarse un componente integral en el manejo de los pacientes con EII.Inflammatory bowel disease is an entity with not wellknown pathogenesis, and important nutritional and metabolic implications because of the high prevalence of malnutrition, the possible implication of dietary factors in its pathogenesis and because of the hypothesis that nutritional intervention could be a primary

  8. Dolor osteomuscular y reumatológico Osteomuscular and rheumatic pain

    OpenAIRE

    J. L. Rodríguez-Hernández

    2004-01-01

    Dentro del dolor osteomuscular y reumatológico encontramos varias entidades. La osteoartrosis u osteoartritis es una enfermedad inflamatoria articular que produce alteraciones estructurales en el cartílago hialino articular y esclerosis del hueso subcondral. Tiene origen multifactorial con síntomas localizados en las articulaciones afectadas y su tratamiento va dirigido al dolor, inflamación, funcionalidad y prevención de deformidades. La artritis reumatoide es una enfermedad crónica que afec...

  9. Oxygen, nitric oxide and articular cartilage

    OpenAIRE

    Fermor, B.; Christensen, S. E.; I Youn; J M Cernanec; C M Davies; Weinberg, J. B.

    2007-01-01

    Molecular oxygen is required for the production of nitric oxide (NO), a pro-inflammatory mediator that is associated with osteoarthritis and rheumatoid arthritis. To date there has been little consideration of the role of oxygen tension in the regulation of nitric oxide production associated with arthritis. Oxygen tension may be particularly relevant to articular cartilage since it is avascular and therefore exists at a reduced oxygen tension. The superficial zone exists at approximately 6% O...

  10. Articular hypermobility simulating chronic rheumatic disease.

    OpenAIRE

    Lewkonia, R M; Ansell, B M

    1983-01-01

    A retrospective survey of 54 children with symptoms associated with articular hypermobility showed only occasional recognition of the syndrome before referral; some patients had been treated for inflammatory arthritis. Of the patients, 78% were girls; their mean age at onset of symptoms (11 years) was 3 years older than the mean age of the boys. Hypermobility was localised rather than generalised in most patients, and this may be an important reason for the apparent under recognition of the s...

  11. Articular cartilage collagen: an irreplaceable framework?

    OpenAIRE

    Eyre, D. R.; Weis, M A; J-J Wu

    2006-01-01

    Adult articular cartilage by dry weight is two-thirds collagen. The collagen has a unique molecular phenotype. The nascent type II collagen fibril is a heteropolymer, with collagen IX molecules covalently linked to the surface and collagen XI forming the filamentous template of the fibril as a whole. The functions of collagens IX and XI in the heteropolymer are far from clear but, evidently, they are critically important since mutations in COLIX and COLXI genes can result in chondrodysplasia ...

  12. Oxygen, nitric oxide and articular cartilage

    Directory of Open Access Journals (Sweden)

    B Fermor

    2007-04-01

    Full Text Available Molecular oxygen is required for the production of nitric oxide (NO, a pro-inflammatory mediator that is associated with osteoarthritis and rheumatoid arthritis. To date there has been little consideration of the role of oxygen tension in the regulation of nitric oxide production associated with arthritis. Oxygen tension may be particularly relevant to articular cartilage since it is avascular and therefore exists at a reduced oxygen tension. The superficial zone exists at approximately 6% O2, while the deep zone exists at less than 1% O2. Furthermore, oxygen tension can alter matrix synthesis, and the material properties of articular cartilage in vitro.The increase in nitric oxide associated with arthritis can be caused by pro-inflammatory cytokines and mechanical stress. Oxygen tension significantly alters endogenous NO production in articular cartilage, as well as the stimulation of NO in response to both mechanical loading and pro-inflammatory cytokines. Mechanical loading and pro-inflammatory cytokines also increase the production of prostaglandin E2 (PGE2. There is a complex interaction between NO and PGE2, and oxygen tension can alter this interaction. These findings suggest that the relatively low levels of oxygen within the joint may have significant influences on the metabolic activity, and inflammatory response of cartilage as compared to ambient levels. A better understanding of the role of oxygen in the production of inflammatory mediators in response to mechanical loading, or pro-inflammatory cytokines, may aid in the development of strategies for therapeutic intervention in arthritis.

  13. Fisiopatología celular de la osteoartritis: el condrocito articular como protagonista = Osteoarthritis cellular pathophysiology: The articular chondrocyte as a central player

    Directory of Open Access Journals (Sweden)

    Sánchez Naranjo, Julio César

    2011-06-01

    Full Text Available La osteoartritis es una de las enfermedades más prevalentes y que más discapacidad produce en todo el mundo, lo que ocasiona costos altos para el paciente y la sociedad. En años recientes se ha venido obteniendo información importante sobre el funcionamiento normal del condrocito, la única célula presente en el cartílago articular y responsable de la síntesis de matriz extracelular. El condrocito responde a las condiciones fluctuantes del medio, generadas por los cambios de presión, modificando su composición iónica y alterando el transporte de solutos y agua en su membrana. Esta capacidad de respuesta es clave para el mantenimiento de la matriz extracelular y, por ende, de un cartílago funcional. Diversos factores relacionados con enfermedades crónicas metabólicas inician una cascada de eventos que termina con una respuesta inadecuada del condrocito ante la carga mecánica, lo cual lleva a un predominio del catabolismo de la matriz y a un cartílago defectuoso que es la base del desarrollo de la osteoartritis. En este proceso están implicadas diversas citocinas y hormonas que afectan la homeostasis del cartílago y que pueden constituirse en blancos terapéuticos prometedores.

  14. Efectividad y seguridad de la viscosuplementación con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA para el tratamiento del dolor secundario a gonartrosis Efficacy and safety of single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA for gonarthrosis pain treatment

    Directory of Open Access Journals (Sweden)

    M. M. Monerris Tabasco

    2012-10-01

    Full Text Available Objetivos: valorar la efectividad y seguridad de la inyección de dosis única de ácido hialurónico estabilizado de origen no animal (NASHA para el tratamiento del dolor secundario a gonartrosis. Material y métodos: se han incluido un total de 37 pacientes afectos de gonartrosis diagnosticada previamente por el Traumatólogo/Reumatólogo en los que ha fracasado el tratamiento conservador y/o que no son tributarios de tratamiento quirúrgico. Se les ha efectuado una infiltración en dosis única de ácido hialurónico estabilizado no animal (NASHA, Durolane®. Se han recogido datos demográficos, efectos adversos e intensidad del dolor (valorada mediante escala verbal numérica y puntuación en los cuestionarios Western Ontario and McMaster Universities Osteoartritis Index (WOMAC y Barthel -basal, a las 2 semanas, a los 3 meses y a los 6 meses de la infiltración-. Se ha considerado efectiva una disminución ≥ 30% durante más de 3 meses en las puntuaciones basales. Resultados: los pacientes son mayoritariamente mujeres (83,8%, con una edad media de 72,8 años (desviación típica -S- = 8,4 e índice de masa corporal medio (IMC 31,9 (S = 6,9. La rodilla infiltrada es izquierda en el 51,7%, derecha en el 41,4% y bilateral en el 6,9% de los pacientes. Han presentado efectos adversos en forma de artralgias bien toleradas el 11,1% de los pacientes. En base a los resultados, la infiltración con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA por gonalgia de origen artrósico provoca una reducción estadísticamente significativa en la intensidad del dolor (escala verbal numérica y WOMAC y de la capacidad funcional (WOMAC en todos los intervalos valorados. Se ha producido una reducción ≥ 30% en la intensidad del dolor en el 54% (valor que coincide con la reducción en la puntuación WOMAC de dolor, en la rigidez en el 62,1% y en la capacidad funcional en el 48,6% de los pacientes. Conclusiones: en nuestros

  15. Intra-Articular Osteoid Osteoma Mimicking Juvenile Arthritis

    Directory of Open Access Journals (Sweden)

    Sidi Yaya Traore

    2014-01-01

    Full Text Available In case of intra-articular osteoid osteoma, misdiagnosis as juvenile arthritis may occur, delaying adequate treatment. We report cases of intra-articular osteoid osteomas in children that were misdiagnosed and initially inappropriately treated with intra-articular corticoid injection. Diagnosis of osteoid osteoma was finally given by CT-scan and appropriate treatment by radiofrequency ablation or surgical ablation was performed. Clinicians and radiologists should be aware of the potentially confusing clinical and imaging findings associated with intra-articular osteoid osteoma.

  16. Vitiligo, con énfasis en su variante inflamatoria Vitiligo, with emphasis in its inflammatory variant

    OpenAIRE

    C I Vera; Díaz, M. C.

    2009-01-01

    El vitiligo inflamatorio es un trastorno melanocitopénico adquirido, de baja frecuencia con características clínicas e histológicas propias. Ocurre en ambos sexos, a cualquier edad. Su fisiopatogenia parece involucrar mecanismos autoinmunes. En su evolución es frecuente la desaparición del componente inflamatorio que resulta en una mácula hipopigmentada clásica; a ello debe anticiparse también nuestra elección terapéutica. Se describe un paciente con vitiligo inflamatorio de resolución espont...

  17. Monografía sobre el intestino grueso : enfermedades inflamatorias intestinales

    OpenAIRE

    López Mora, Gema

    2014-01-01

    El intestino grueso es un órgano con forma de tubo, de aproximadamente un metro y medio de largo, que forma parte del sistema digestivo. Consta de varias partes llamadas ciego (con su apéndice vermiforme); colon, en donde ponemos diferenciar colon ascendente, transverso, descendente y sigmoide; recto y ano. Sus paredes están cubiertas por un epitelio simple cilíndrico, que no presenta pliegues ni vellosidades y, que forma numerosas glándulas mucosas tubulares llamadas criptas de Lierberkühn, ...

  18. Fracturas articulares de calcáneo: tratamiento incruento versus quirúrgico

    OpenAIRE

    Gracia Rodríguez, Indalecio; Pérez Aznar, A. T.; Sanz Reig, J.; Lizaur Utrilla, A.

    1997-01-01

    Se analiza la problemática que supone el tratamiento de las fracturas articulares de calcáneo. Han sido revisadas 85 fracturas tratadas, 43 ortopédicamente, y 42 según técnica de Westhues-Ehalt. El seguimiento medio fue de 24 meses. Los resultados clínicos fueron satisfactorios en el 43,5 %, no existiendo correlación con la disminución radiográfica del ángulo de Bóhler. El tipo de tratamiento empleado no influyó significativamente en el resultado clínico final, pero sí el grado...

  19. Asma bronquial. Estado del arte.

    Directory of Open Access Journals (Sweden)

    Jorge Salazar

    2009-10-01

    Full Text Available Para infinidad de personas el asma es su problema de salud. El diagnóstico y el tratamiento varían dependiendo de la magnitud del compromiso y la causa que produce la reacción inflamatoria en los pulmones. La prevención y el tratamiento serán mejores si la población y los pacientes reconocen la necesidad de evitar determinadas exposiciones ambientales y el uso de medicamentos con la frecuencia necesaria. Ahora los médicos generales conocen mejor la fisiología y patología de esta enfermedad y los mecanismos de acción de los diferentes medicamentos. El tratamiento con aerosol debe comprenderse mejor para evitar efectos colaterales en los pacientes y darles una mejor calidad de vida. Se discuten los nuevos tratamientos para el estado asmático y en las unidades de cuidados intensivos.

  20. Phosphorylation of proteoglycans from human articular cartilage

    International Nuclear Information System (INIS)

    Previous studies have shown that sulfated proteoglycans from human articular and epiphyseal cartilage were phosphorylated. These macromolecules contribute to the stiffness and resiliency of this tissue. We demonstrate here that the phosphate moieties are an integral part of proteoglycan subunits. Specifically, evidence is presented which indicates that proteoglycan monomers contain 3 to 4 phosphate moieties per core protein and that these appear to exist as phosphoserine residues. Furthermore, the data illustrate that human articular cartilage also contains more than 20 different phosphoproteins, some of which are closely associated with proteoglycan aggregates. Proteoglycan subunits were purified from extracts of articular cartilage or from media fractions which had been used to label tissue specimens with 32P-orthophosphate. Chemical and radiographic analyses revealed that the phosphate concentration with respect to sulfate and uronic acid content remained constant when purified proteoglycan monomers were subjected to equilibrium ultracentrifugation and size-exclusion chromatography. That the phosphate moieties were bound to proteoglycan monomers via monoester linkages was indicated by the release of 32P-orthophosphate from proteoglycan subunits incubated under mild alkaline conditions or reacted with acid or alkaline phosphatases. Identification of serine residues in the core protein as the sites of phosphorylation was made by autoradiography of thin layer plates on which hydrolyzed samples of purified 32P-proteoglycan subunits had been subjected to 2-dimensional electrophoresis/chromatography. Quantification of 3 to 4 phosphate moieties per core protein of 200,000 daltons was made by chemical analysis of inorganic phosphate released from proteoglycans by acid hydrolysis

  1. Advances in treatment of articular cartilage injuries

    Directory of Open Access Journals (Sweden)

    Yuan-cheng LI

    2013-05-01

    Full Text Available Cartilage is a kind of terminally differentiated tissue devoid of vessel or nerve, and it is difficult to repair by itself after damage. Many studies for the treatment of cartilage injuries were performed in recent years aiming at repair of the structure and restoration of its function for injured joint. This article reviews the traditional methods of treatment for cartilage injuries, such as joint lavage with the aid of arthroscope, abrasion chondroplasty, laser abrasion and chondroplasty, and drilling of the subchondral bone-marrow space. The research advances in treatment of articular cartilage injuries with tissue engineering were summarized.

  2. Viral articular deformations in a goat

    International Nuclear Information System (INIS)

    A goat belonging to an animal aid association was presented for bilateral deformation of the tarsus and carpus and signs of high-grade pain. ELISA serology was positive for Caprine Arthritis-Encephalitis Virus. Radiography revealed marked osseous remodelling of the tarsus. The blood fibrinogen concentration was very elevated. On infected commercial farms, it is recommended that both seropositive animals and their offspring are culled when the level of infected is low, or to separate the kids from the mothers at an early age. In this case, palliative treatment was prescribed based on non-steroidal anti-inflammatory drugs, antibiotics and articular puncture-lavages

  3. A population-based study on the incidence of inflammatory bowel disease in Oviedo (Northern Spain Incidencia de la enfermedad inflamatoria intestinal (EII en población general en el área de Oviedo

    Directory of Open Access Journals (Sweden)

    L. Rodrigo

    2004-05-01

    Full Text Available Objective: to assess the incidence of inflammatory bowel disease in Oviedo (Northern Spain, and to describe the clinical features of new patients. Patients and methods: a prospective population-based study was made at the Health Area IV, Principality of Asturias (Oviedo, 312,324 inhabitants. All new diagnosed patients with inflammatory bowel disease were registered over a 2-year period. Results: a total of 85 patients were included, 47 of these with ulcerative colitis (UC, 37 with Crohn's disease (CD, and 1 with undetermined colitis. The overall adjusted incidence rate of UC and CD per 10(5 inhabitants between 15-64 years was 9.1 (95% CI: 5-13.1 and 7.5 (95% CI: 3.8-11.2, respectively. The global male/female ratio was 0.9, without significant differences between both diseases. CD patients were younger than those with UC (33 ± 15 years vs 45 ± 20 years; p Objetivo: conocer la incidencia de enfermedad inflamatoria intestinal en el área de Oviedo y describir las características clínicas de los nuevos pacientes. Pacientes y métodos: estudio prospectivo poblacional en el Área Sanitaria IV del Principado de Asturias (Oviedo, 312.324 habitantes. Fueron registrados todos los pacientes nuevos diagnosticados de enfermedad inflamatoria intestinal en un periodo de 2 años consecutivos. Resultados: se incluyeron un total de 85 pacientes, 47 con colitis ulcerosa (CU, 37 con enfermedad de Crohn (EC y 1 con colitis indeterminada (CI. La tasa de incidencia ajustada por 10(5 habitantes entre 15 y 64 años, de CU y EC, fue de 9,1 para CU (IC95%: 5-13,1 y 7,5 para la EC (IC95%: 3,8-11,2. La proporción hombre/mujer fue de 0,9, sin diferencias significativas entre ambas enfermedades. Los pacientes con EC eran más jóvenes que los que tenían CU (33 ± 15 años vs 45 ± 20 años; p<0,05. La mayor parte de los pacientes con EC tenían menos de 35 años (65%, mientras que los que presentaban CU fueron diagnosticados entre los 25 y 64 años (81%. La extensi

  4. Ozonoterapia sistémica e intra-articular en la artritis de la articulación temporomandibular por artritis reumatoide

    Directory of Open Access Journals (Sweden)

    Ivonne Méndez-Pérez

    2010-01-01

    Full Text Available Se estudió el efecto de la ozonoterapia intra-articular combinada con la vía sistémica (vía rectal y se comparó con la sola aplicación por vía intra-articular en pacientes con artritis de la articulación temporomandibular (ATM por artritis reumatoide (AR mediante la evaluación clínica del dolor a la masticación, chasquido y trismo. Fueron estudiados veinte pacientes, divididos en dos grupos de diez cada uno, el primero recibió ozonoterapia intra-articular (concentración de ozono 10 mg/L y volumen de 3 mL, a razón de dos aplicaciones por semana, durante cinco semanas, y el segundo, terapia combinada (igual al primer grupo más ozono administrado por insuflación rectal, a una concentración de 30 hasta 40 mg/L y un volumen de 100 hasta 200 mL, veinte aplicaciones. Se evaluó el grosor del cartílago articular (por ultrasonido, al inicio y al final del tratamiento al igual que los síntomas clínicos: dolor a la masticación, chasquido y trismo. Como resultado, se obtuvo una disminución significativa de todos los síntomas estudiados, así como del grosor del cartílago articular diagnosticado en el estudio ultrasonográfico, teniendo una respuesta más rápida en el grupo de la terapia combinada. Se concluyó que ambas formas de tratamiento demuestran efectos beneficiosos en la artritis de la articulación temporomandibular de pacientes con artritis reumatoide, aunque la terapia combinada resulta la más eficiente, resultado que no ha sido reportado con anterioridad.

  5. Manejo clínico del quiste periapical

    OpenAIRE

    Clara Vergara Hernández

    2013-01-01

    ResumenEl quiste periapical es una lesión inflamatoria de los maxilares formada en el periápice de dientes con pulpa necrótica e infectada siendo una secuela directa de un granuloma apical, están asociados a la raíz dentaria y se encuentran con mayor frecuencia en el maxilar superior. Por lo general no provocan síntomas y su lenta evolución hace que el paciente no se percate del mismo hasta que aparece la asimetría facial. Se presenta un caso correspondiente a un paciente masculino con lesión...

  6. Is safety infliximab during pregnancy in patients with inflammatory bowel disease? ¿El tratamiento con infliximab es seguro durante el embarazo en pacientes con enfermedad inflamatoria intestinal?

    Directory of Open Access Journals (Sweden)

    Federico Argüelles-Arias

    2012-02-01

    foetus. In fact, in our study and in some cases, its withdrawal may lead to a worsening of the disease. However, further control studies are required with larger samples to obtain more representative findings.Introducción: la enfermedad inflamatoria intestinal (EII es un trastorno crónico que debuta en la mayoría de los casos durante la edad reproductiva. Existen pocos datos sobre la seguridad durante el embarazo de los tratamientos disponibles, entre ellos los denominados biológicos, y estos están basados en resultados de casos esporádicos. Objetivos: determinar la seguridad del tratamiento con infliximab (IFX durante el embarazo en mujeres con EII. Un segundo objetivo es observar el efecto que sobre la actividad de la enfermedad tiene el abandono del tratamiento. Material y métodos: se trata de un estudio retrospectivo en el que se incluyeron mujeres con EII embarazadas y que estaban en tratamiento con IFX durante el embarazo. Se incluyeron en el estudio a 5 hospitales de España. La actividad de la enfermedad se midió según el CDAI en la enfermedad de Crohn (EC y la de la colitis ulcerosa (CU según el índice de Truelove-Witts en cada trimestre del embarazo. La edad gestacional, el peso y las enfermedades del feto se determinaron al nacimiento. Resultados: se incluyeron doce mujeres con una edad media de 29 años, 4 diagnosticadas de CU y 8 de EC, con una duración media de la enfermedad de 7 años. Todas salvo una, que se diagnosticó durante el embarazo estaban siendo tratadas con IFX en el momento de la concepción. Seis pacientes recibieron el tratamiento de forma ininterrumpida durante todo el embarazo, 2 suspendieron el tratamiento de forma voluntaria y a tres se les suspendió el tratamiento en el tercer trimestre. Recibieron una dosis media de IFX de 400 mg cada 8 semanas. De las 6 pacientes que recibieron tratamiento continuo, el 50% se mantuvo en remisión. De las pacientes que abandonaron el tratamiento, un 83,3% (todas menos una presentaron un

  7. Efecto de las cargas articulares sobre el flujo y pH salival Effect of TMJ loading on salivary flow and pH

    OpenAIRE

    RJ Castro; C. Bravo; V Alcaino; RA Giacaman

    2011-01-01

    Una alteración del flujo salival es clave en el desarrollo de caries, enfermedad periodontal e infecciones oportunistas. El flujo salival está determinado por diversos estímulos que actúan sobre receptores de distinta naturaleza, entre ellos mecanoreceptores articulares. Algunos estudios demuestran que las cargas articulares actúan sobre estos receptores, modificando cualitativa y cuantitativamente la secreción salival. El objetivo de este estudio fue determinar si existe una relación entre l...

  8. [Articular chondrocalcinosis after 80 years of age].

    Science.gov (United States)

    Memin, Y; Monville, C; Ryckewaert, A

    1978-02-01

    In 108 women over 80 (mean age 88,4 years, extremes 80 and 99 years) hospitalized in a geriatric service for various reasons, radiograms were made of both knees in the frontal aspect on standard film to detect calcinosis of the meniscus and chondrocalcinosis of the joint. In 25 women (23.1%) the radiographs revealed calcinosis of the meniscus with or without chondrocalcinosis. In these 25 cases a lateral X-ray was also made of the two knees, frontal X-rays were made of the pelvis, thumbs and shoulders. In 22 cases (88%) these revealed calcification of the fibrocartilages or articular cartilages in joints other than the knee. Seven of the 25 women had at least one attack of articular inflammation (especially of the knee) resembling a pseudo-gout crisis. The frequency of chronic arthropathies resembling arthroses was high in the 25 patients with chondrocalcinosis: 8 (32%) had an internal or external femoro-tibial arthrosis, as against 11 of the 83 patients (13%) of the same age without chondrocalcinosis, a significant difference. Eleven of the 25 women had signs of femororotular arthrosis on the lateral X-rays of the knees, 5 had coxarthrosis (with in 3 cases a radiological image of fibrocartilaginous or coxofemoral cartilaginous calcification). One women had chronic radiocarpal arthropathy evocative or chondrocalcinosis. Ten had a scaphotrapezoidal arthrosis, 5 arthrosis of the shoulder, 3 with radiological aspect of glenohumeral chondrocalcinosis. PMID:644241

  9. Papel de la ventilación mecánica durante la circulación extracorporea sobre los mediadores de la respuesta inflamatoria

    OpenAIRE

    López Gomez, Amparo

    2015-01-01

    RESUMEN TESIS: PAPEL DE LA VENTILACIÓN MECÁNICA DURANTE LA CIRCULACIÓN EXTRACORPÓREA SOBRE LOS MEDIADORES DE LA RESPUESTA INFLAMATORIA. La Cardiopatía Isquémica (CI) representa la mayor causa de mortalidad en países desarrollados. En España, supone el mayor número de muertes cardiovasculares, siendo el infarto agudo de miocardio (IMA) la enfermedad isquémica más frecuente. Datos recientes sugieren que se ha producido un aumento de la prevalencia de pacientes con CI . La revasculariza...

  10. Inflamación intestinal y dismotilidad en un modelo experimental de enfermedad inflamatoria intestinal en la rata mecanismos de acción implicados en la ciclicidad y cronicidad /

    OpenAIRE

    Porras Pardo, Mònica

    2006-01-01

    Bajo el nombre de Enfermedad Inflamatoria Intestinal (EII) se agrupan dos patologías inflamatorias crónicas y recidivantes de etiología desconocida: la enfermedad de Crohn y la colitis ulcerosa. La relativamente elevada incidencia de estas patologías hace que estudiar su etiopatogenia sea un objetivo importante, ya que actualmente no existe ningún tratamiento curativo y/o que prevenga la recidiva A pesar de que los pacientes afectados de EII presentan síntomas relacionados con alteraciones de...

  11. Patología infecciosa: vulvovaginitis, enfermedades de transmisión sexual, enfermedad inflamatoria pélvica, abscesos tubo-ováricos Infectious pathology: vulvovaginitis, sexually transmitted diseases, pelvic inflammatory disease, tubo-ovarian abscesses

    Directory of Open Access Journals (Sweden)

    M. Ibarrola

    2009-01-01

    Full Text Available Las enfermedades de transmisión sexual son aquellas en las que la principal vía de infección es el contacto íntimo. Son numerosas las pacientes que acuden a urgencias por esta causa, tanto por la clínica como por las implicaciones sociales. Los síntomas más frecuentes son dolor abdominal bajo, sangrados vaginales, o flujo vaginal excesivo o molesto. Las vulvovaginitis son uno de los problemas principales en la práctica clínica diaria del ginecólogo. La úlcera genital cuya etiología principal es el herpes, seguida de la sífilis y el chancroide incrementa el riesgo para contraer la infección por el VIH y modifica el curso de otras enfermedades de transmisión sexual. La enfermedad pélvica inflamatoria engloba a las infecciones del tracto genital superior femenino. La importancia del diagnóstico precoz y su tratamiento adecuado reside tanto por las complicaciones en la fase aguda como por las secuelas, que incluyen el dolor crónico y la esterilidad.Sexually transmitted diseases are those where the principal path of infection is through intimate contact. Numerous patients attend Accidents and emergencies for this reason, both because of the clinical features and because of social implications. The most frequent symptoms are lower abdominal pain, vaginal bleeding or excessive or troubling vaginal flow. Vulvovaginites are one of the principal problems in the everyday clinical practice of gynaecology. A genital ulcer whose principal aetiology is herpes, followed by syphilis and chancroid, increases the risk of contracting HIV infection and alters the course of other sexually transmitted diseases. Inflammatory pelvic disease encompasses infections of the upper female genital tract. The importance of early diagnosis and suitable treatment is both due to the complications in its acute phase and to its sequels, which include chronic pain and sterility.

  12. Deslumbramientos del mercado

    OpenAIRE

    Monique Selim

    2006-01-01

    Con eje en los diferentes aspectos que adopta el actual proceso de mundialización de la lógica del mercado y expansión capitalista, aún en países socialistas, el presente artículo plantea la necesidad de una reflexión antropológica susceptible de articular el surgimiento de nuevas formas de dominación y representación simbólicas. Se discute el aparente efecto de unificación intelectual producido por la hegemonía del mercado respecto de hechos sociales heterogéneos dados en la historia recient...

  13. Inestabilidad compleja del codo

    OpenAIRE

    Héctor Gabriel Díaz Carrillo; José A. Meriño Labrada; Nelson Leyva Pérez

    2014-01-01

    La inestabilidad compleja del codo es de reciente descripción y controversial en sus resultados; es el estado que se deriva del daño estructural y funcional, producido por la incongruencia de las superficies articulares y las estructuras ligamentosas que estabilizan el codo. Se realizó un estudio descriptivo prospectivo, en el período comprendido entre enero de 2011 y abril de 2013, en una muestra no probabilística de ocho pacientes (diez codos), seleccionados según criterios de inclusión y e...

  14. Imaging diagnosis of the articular cartilage disorders

    International Nuclear Information System (INIS)

    Objective: To evaluate the diagnosis and differential diagnosis among the chronic osteoarthritis, rheumatoid arthritis and other chronic cartilage lesions on the plain films and MR images. Methods: Eighty-nine cases, including 115 joints, underwent plain film and MRI examination, and enhanced MRI scan was performed on 32 of them, including 44 joints. MRI scan sequences consisted of T1WI, T2WI + PDWI, STIR, and 3D FS SPGR. There were 90 knee joints in this group and each of the articular cartilage was divided into four parts: patella, femoral medial condyle, femoral lateral condyle, and tibia facet on MR images. The cartilage disorders were classified according to the outerbridge method. In addition, 61 cases including 75 joints were observed as a control group on the plain films and MR images. Results: 115 cartilage lesions were found on MR images, in which thinness of the cartilage (58 cases, 50.4%), bone changes under the cartilage (22 cases, 19.7%), medullar edema (22 cases, 19.7%), and synovial hyperplasia (52 cases, 45.2%) were seen. The patella cartilage was the most likely affected part (81/90, 90%). So the patellar cartilage lesions were divided as group 1 (grade I-II) and group 2 (grade III-IV) on MR images, which were compared with the plain film signs. The narrowing of the joint space and saccules under the articular surface were statistically significant with each other, and χ2 values were 9.349 and 9.885, respectively (P=0.002). Conclusion: No constant signs could be seen on the plain films with grade I-II cartilage disorders. While the narrowing joint space and saccules under the joint surface could be seen on them with grade III-IV cartilage disorders, which were mainly correlated with the cartilage disorders and bone changes under the articular cartilages. A combination of the plain films and MR images is the best imaging method for examining the joints and joint cartilages. Enhanced MRI scan is very helpful on the diagnosis and differential

  15. Modelos animales para el estudio de la respuesta inflamatoria sistémica y de nutrición parenteral Animal models for the study of systemic inflammatory response and parenteral nutrition

    Directory of Open Access Journals (Sweden)

    J. M. Morán Penco

    2007-04-01

    Full Text Available El Síndrome de Respuesta Inflamatoria Sistémica (SRIS parece desencadenarse por la activación de un tipo de receptores llamados Toll-Like, propios de las células de respuesta inflamatoria y que, a través de señales citosólicas específicas, producen una cascada de reacciones que activan las Citocinas, Factores de Crecimiento y otros mediadores inflamatorios. En este trabajo, repasamos y discutimos varias clasificaciones de Modelos Animales para el estudio del SRIS y proponemos que estos modelos se dividan según los objetivos concretos a estudiar; que podrían ser los siguientes: 1º Para el estudio de los genes reguladores de los receptores Innatos y Adaptativos, de la respuesta inmunoinflamatoria. 2º Para el estudio de los receptores de señalización (Citocinas y Factores de Crecimiento. 3º Para el estudio de la respuesta frente a los señalizadores. 4º Para el estudio de tratamientos mediante bloqueo anti-inflamatorio específico (ILs, TNF y otros. 5º Modelos específicos de Sepsis. 6º Otros Modelos Inductores de SRIS. 7º Para el estudio de Modelos Terapéuticos diversos: -Tratamientos Anti-Inflamatorios. -Tratamientos Anticoagulantes: Inhibición de la Coagulación en ensayos Humanos-Fase II, con anticoagulantes: Antitrombina III, PCA y TFPI. -Tratamientos Antibióticos. -Tratamientos con Reposición de Volúmenes. -Tratamientos Quirúrgicos. En lo que respecta al apartado de Modelos animales para el estudio de la Nutrición Parenteral, podríamos hacer la siguiente clasificación y resumen de lo tratado: 1. Modelos Animales para el estudio de la Vía Parenteral de Administración. 2. Modelos para el estudio de la viabilidad, absorción y tolerancia locales en la vía de administración. 3. Modelos para el estudio de las Complicaciones. 4. Modelos animales para el estudio de la farmacodinamia, metabolización e investigación de la tolerancia de nuevas moléculas o substratos.The systemic inflammatory response syndrome (SRIS

  16. Lavado articular en el tratamiento de la artrosis de la rodilla: descripción de una nueva técnica y valoración de la eficacia y tolerancia de la misma

    OpenAIRE

    Caracuel Ruiz, Miguel Ángel

    2002-01-01

    El Lavado Articular (LA) es una medida terapéutica utilizada para el tratamiento de la patología articular, sobre articulaciones accesibles y desarrollada fundamentalmente en la patología de rodilla. El efecto del LA ha sido estudiado en pocas indicaciones concretas: artritis séptica, artritis reumatoide, condrocalcinosis y artrosis. Los objetivos de esta tesis son: 1) Valorar la eficacia del LA en pacientes con patología osteoarticular de rodilla (artrosis, condrocalcinosis y artritis). 2) C...

  17. Epidemiology of chronic inflammatory bowel disease in the Northern area of Huelva Estudio epidemiológico de la enfermedad inflamatoria intestinal en la zona norte de Huelva

    Directory of Open Access Journals (Sweden)

    A. Garrido

    2004-10-01

    Full Text Available Objective: to know the different epidemiologic aspects of chronic inflammatory bowel disease (IBD in the Northern area of the province of Huelva. Material and methods: we carried out a retrospective (1980-1996 and prospective (1996-2003 study of all patients diagnosed with IBD in the Northern area of Huelva, with 77,856 inhabitants. The distribution of Crohn's disease (CD and ulcerative colitis (UC was analyzed, as well as sex, age and smoking habit at the time of diagnosis, familial aggregation, appendicectomy rate, phenotype (anatomical site and clinical types, extraintestinal manifestations, and immunosuppressive therapy or surgical requirements. Results: 70 patients with IBD were studied, 40 with UC and 30 with CD. Sex distribution was 39 (55.7% males (55% with CD vs 56.6% with UC; NS and 31 (44.3% females (45% with CD vs 43.3% with UC; NS. Mean age at presentation was 44.7 ± 19.32 years in UC vs 32.3 ± 16.43 in CD; p Objetivo: conocer los distintos aspectos epidemiológicos de la enfermedad inflamatoria intestinal (EII en la zona norte de la provincia de Huelva. Material y métodos: se realizó un estudio retrospectivo (1980-1996 y prospectivo (1996-2003 sobre los pacientes diagnosticados de EII en la zona norte de Huelva con 77.856 habitantes. Se ha analizado la distribución de enfermedad de Crohn (EC y colitis ulcerosa (CU, sexo, edad y hábito tabáquico en el momento del diagnóstico, agregación familiar, antecedentes de apendicetomía, fenotipo (extensión y tipos clínicos, manifestaciones extraintestinales y necesidad de tratamiento inmunosupresor y/o quirúrgico. Resultados: se estudiaron 70 pacientes con EII, 40 con CU y 30 con EC. Un total de 39 (55,7% eran varones (55% en EC frente a 56,6% en CU; NS y 31 (44,3% mujeres (45% en EC frente a 43,3% en CU; NS. La media de edad en el momento de diagnóstico fue de 44,7±19,32 para CU frente a 32,3±16,43 para EC (p<0,001. La asociación familiar fue del 7,1%. Referían apendicectom

  18. Extra-Articular Ganglion Cysts around the Knee Joint

    OpenAIRE

    Park, Sang-Eun; Panchal, Karnav; Jeong, Jae-Jung; Kim, Young-Yul; Ji, Jong-Hun; Park, Sung-Ryeoll; Park, Min-Kyu

    2015-01-01

    Purpose The purpose of this study was to report clinical results of open excision of extra-articular ganglion cysts around the knee joint combined with arthroscopic management of intra-articular pathologies if present. Materials and Methods Of the total 107 cases of cystic lesions around the knee, 23 cases of extra-articular ganglion cysts were reviewed between January 2006 and July 2011. There were 13 males and 10 females with a mean age of 48 years (range, 30 to 73 years). The mean follow-u...

  19. Evolución del germen dental trasplantado heterotópicamente en la dermis: un estudio histológico en la rata

    OpenAIRE

    Mezadri, Telmo José; Rivero Tames, David; Boabaid, Fernanda; Armengol, José A.

    2004-01-01

    En este estudio hemos analizado la potencialidad de desarrollo del germen dental en fase de corona. Para ello, los gérmenes dentales de rata recién nacida fueron trasplantados en las bolsas dérmicas de la oreja de ratas isogénicas. Siete y catorce días después del trasplante, se desarrollaron las estructuras morfológicas dentales típicas, con ameloblastos y odontoblastos bien diferenciados. Ulteriormente, los procesos de reacción inflamatoria del tejido huésped con infilt...

  20. Intra-articular ganglion cysts of the cruciate ligaments

    Energy Technology Data Exchange (ETDEWEB)

    Tyrrell, P.N.M.; Cassar-Pullicino, V.N.; McCall, I.W. [Department of Diagnostic Imaging and The Institute of Orthopaedics, The Robert Jones and Agnes Hunt Orthopaedic and District Hospital, Oswestry, Shropshire (United Kingdom)

    2000-08-01

    Intra-articular ganglion cysts of the cruciate ligaments are associated with non-specific clinical signs and symptoms. Familiarity with the MR appearances in particular is important to make an accurate diagnosis, exclude associated abnormalities, and avoid misdiagnosis. (orig.)

  1. Intra-articular ganglion cysts of the cruciate ligaments

    International Nuclear Information System (INIS)

    Intra-articular ganglion cysts of the cruciate ligaments are associated with non-specific clinical signs and symptoms. Familiarity with the MR appearances in particular is important to make an accurate diagnosis, exclude associated abnormalities, and avoid misdiagnosis. (orig.)

  2. Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan

    Science.gov (United States)

    Yamada, Jun; Abula, Kahaer; Inoue, Makiko; Sekiya, Ichiro; Muneta, Takeshi

    2014-01-01

    Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint inflammation and cartilage degeneration. To test this hypothesis, we examined the effects of follistatin in a carrageenan-induced mouse arthritis model. Synovitis induced by intra-articular injection of carrageenan was significantly alleviated by preinjection with follistatin. Macrophage infiltration into the synovial membrane was significantly reduced in the presence of follistatin. In addition, follistatin inhibited proteoglycan erosion induced by carrageenan in articular cartilage. These data indicate that activin-follistatin signaling is involved in joint inflammation and cartilage homeostasis. Our data suggest that follistatin can be a new therapeutic target for inflammation-induced articular cartilage degeneration. PMID:25574420

  3. Simultaneous Magnetic Resonance Imaging and Consolidation Measurement of Articular Cartilage

    Directory of Open Access Journals (Sweden)

    Robert Mark Wellard

    2014-05-01

    Full Text Available Magnetic resonance imaging (MRI offers the opportunity to study biological tissues and processes in a non-disruptive manner. The technique shows promise for the study of the load-bearing performance (consolidation of articular cartilage and changes in articular cartilage accompanying osteoarthritis. Consolidation of articular cartilage involves the recording of two transient characteristics: the change over time of strain and the hydrostatic excess pore pressure (HEPP. MRI study of cartilage consolidation under mechanical load is limited by difficulties in measuring the HEPP in the presence of the strong magnetic fields associated with the MRI technique. Here we describe the use of MRI to image and characterize bovine articular cartilage deforming under load in an MRI compatible consolidometer while monitoring pressure with a Fabry-Perot interferometer-based fiber-optic pressure transducer.

  4. Insight into osteo-articular digital tomosynthesis: a pictorial essay

    International Nuclear Information System (INIS)

    The objectives of this pictorial essay are to describe osteo-articular imaging using digital tomosynthesis. We provide characteristic examples in eight patients. Digital tomosynthesis allows easy, fast and low-dose imaging, with excellent spatial resolution.

  5. Relationship between socio-demographic and clinical variables, and health-related quality of life in patients with inflammatory bowel disease Relación entre variables sociodemográficas y clínicas y calidad de vida relacionada con la salud en pacientes con enfermedad inflamatoria intestinal

    Directory of Open Access Journals (Sweden)

    B. López Blanco

    2005-12-01

    Full Text Available Objective: the principal aim of the present study is to evaluate the influence of socio-demographic and clinical variables on health-related quality of life (HRQL in patients with inflammatory bowel disease. Patients and method: this was a cross-sectional study. health-related quality of life was measured with the Inflammatory Bowel Disease Questionnaire (IBDQ. A total of 120 patients, 60 with ulcerative colitis and 60 with Crohn's disease, participated in the study. Results: no significant differences were observed between ulcerative colitis and Crohn's disease patients in IBDQ dimensions. However, a multivariate analysis revealed that sex, type of treatment, extraintestinal symptoms, number of relapses in previous year, satisfaction with surgery, and need for psychological support were related to HRQL. Conclusions: the identification of these variables associated with HRQL in patients with inflammatory bowel disease shows them to be basically non-disease factors. Knowledge of such elements can turn out to be very useful in order to guide future research and modify specific factors in further interventions.Objetivo: el objetivo principal del presente trabajo consiste en evaluar la influencia de las variables sociodemográficas y clínicas en la calidad de vida relacionada con la salud de los pacientes con enfermedad inflamatoria intestinal. Pacientes y método: se trata de un estudio transversal. La calidad de vida relacionada con la salud se investigó utilizando el "Inflammatory Bowel Disease Questionnaire" (IBDQ. Un total de 120 pacientes, 60 con colitis ulcerosa y 60 con enfermedad de Crohn participaron en el estudio. Resultados: no se apreciaron diferencias significativas en la calidad de vida relacionada con la salud en las dimensiones del IBDQ en función de la enfermedad, sin embargo, tras el análisis multivariante, el sexo, el tipo de tratamiento, las manifestaciones extradigestivas, el número de recaídas anual, la satisfacción con

  6. Imaging diagnosis of the juxta-articular bone cyst

    International Nuclear Information System (INIS)

    Objective: To investigate the imaging features of the juxta-articular bone cyst(intra- osseous ganglia). Methods: The imaging findings of 54 cases histopathologically confirmed were studied retrospectively. X-ray, CT, and MRI were performed in 46 eases, 30 cases, and 14 cases, respectively. Results: Of the 54 cases, 27 arised from the ankle (including multiple lesions), 16 from the knee joint, 7 from the hip joint, 1 from the proximate end of the humerus, ulna, trapezium bone, the first phalange in each, and 1 from the talus and the distal end of the tibia. There were 43 cases (44 lesions) in the ankle and knee joints, with 29 (65.9%) lesions located in the medial articular surface. Fifty-four cases had thinning sclerotic rim, showing a unilocular round osteolytic appearance in 44 cases and a multiloculated-cystic appearance with septa in 10 cases. Discontinuous articular surface were seen in 15 cases, reticular surface collapse in 1, gas density in 3 and fluid-fluid plane in 1. (1) On x-ray films, 46 cases (47 lesions) with well-defined sclerotic rim revealed round, arch or irregular lyric areas at the adjacent articular surface. The fissures were found at the adjacent articular surface in 6 lesions. No joint spaces were abnormal. (2)On CT, 30 cases with sclerotic rim showed round in 19 lesions, arch in 3, and irregular in 8. The fissures were seen at the adjacent articular surface in 14 lesions. The density showed homogeneous in 27 lesions, and gas existed in 3. (3) Fourteen cases (15 lesions)showed hypointense to isointense signal on MR T1WI and hyperintense signal on T2WI. Fluid-fluid plane was found in 1 case. The fissures were observed at the adjacent articular surface in 8 lesions. 7 cases showed swelling soft tissue. Conclusion: The characteristic locations combined with the typical imaging features may suggest the diagnosis of jaxta-articular bone cyst. (authors)

  7. The Classic: Chapter XVIII. Operative Treatment in Chronic Articular Ostitis

    OpenAIRE

    Gibney, Virgil P.

    2009-01-01

    This Classic article is a reprint of the original work by Virgil P. Gibney, Chapter XVIII. Operative Treatment in Chronic Articular Ostitis. An accompanying biographical sketch of Virgil P. Gibney, MD, is available at DOI 10.1007/s11999-009-1166-2. The Classic Article is ©1884 and is abridged from Gibney VP. Operative treatment in chronic articular ostitis. In: The Hip and Its Diseases. New York, NY, London, UK: Bermingham & Co; 1884:388–402.

  8. Type III Collagen, a Fibril Network Modifier in Articular Cartilage*

    OpenAIRE

    Wu, Jiann-Jiu; Weis, Mary Ann; Kim, Lammy S.; Eyre, David R.

    2010-01-01

    The collagen framework of hyaline cartilages, including articular cartilage, consists largely of type II collagen that matures from a cross-linked heteropolymeric fibril template of types II, IX, and XI collagens. In the articular cartilages of adult joints, type III collagen makes an appearance in varying amounts superimposed on the original collagen fibril network. In a study to understand better the structural role of type III collagen in cartilage, we find that type III collagen molecules...

  9. Biologic therapies for chronic inflammatory bowel disease Tratamientos biológicos en la enfermedad inflamatoria crónica intestinal

    Directory of Open Access Journals (Sweden)

    M. P. Martínez-Montiel

    2006-04-01

    Full Text Available Crohn's disease (CD and ulcerative colitis (UC make up the so-called chronic inflammatory bowel disease (IBD. Advances in the understanding of IBD pathophysiologic mechanisms in the last few years have allowed the development of novel therapies such as biologic therapies, which at least theoretically represent a more specific management of this disease with fewer side effects. Currently, the only effective and widely accepted biologic therapy for the treatment of intraluminal, fistulizing CD, both for remission induction and maintenance, is infliximab. The role of other monoclonal antibodies such as adalimumab is not clearly established. It could be deemed an alternative for patients with allergic reactions to infliximab, and for those with lost response because of anti-infliximab antibody development. However, relevant issues such as dosage and administration regimen remain to be established. Anti-integrin α4 therapies, despite encouraging results in phase-3 studies, are still unavailable, as their marketing authorization was held back in view of a number of reports regarding progressive multifocal leukoencephalopathy cases. Immunostimulating therapy may be highly relevant in the near future, as it represents a novel strategy against disease with the inclusion of granulocyte-monocyte colony-stimulating factors. Regarding ulcerative colitis, results from the ACT-1 and ACT-2 studies showed that infliximab is also useful for the management of serious UC flare-ups not responding to standard treatment, which will lead to a revision of therapeutic algorithms, where this drug should be given preference before intravenous cyclosporine. In the next few years, the role of anti-CD3 drugs (vilisilizumab, T-cell inhibiting therapies, and epithelial repair and healing stimulating factors will be established.La enfermedad de Crohn (EC y la colitis ulcerosa (CU constituyen la denominada enfermedad inflamatoria crónica intestinal (EII. Los avances producidos

  10. Articular cartilage: from formation to tissue engineering.

    Science.gov (United States)

    Camarero-Espinosa, Sandra; Rothen-Rutishauser, Barbara; Foster, E Johan; Weder, Christoph

    2016-05-26

    Hyaline cartilage is the nonlinear, inhomogeneous, anisotropic, poro-viscoelastic connective tissue that serves as friction-reducing and load-bearing cushion in synovial joints and is vital for mammalian skeletal movements. Due to its avascular nature, low cell density, low proliferative activity and the tendency of chondrocytes to de-differentiate, cartilage cannot regenerate after injury, wear and tear, or degeneration through common diseases such as osteoarthritis. Therefore severe damage usually requires surgical intervention. Current clinical strategies to generate new tissue include debridement, microfracture, autologous chondrocyte transplantation, and mosaicplasty. While articular cartilage was predicted to be one of the first tissues to be successfully engineered, it proved to be challenging to reproduce the complex architecture and biomechanical properties of the native tissue. Despite significant research efforts, only a limited number of studies have evolved up to the clinical trial stage. This review article summarizes the current state of cartilage tissue engineering in the context of relevant biological aspects, such as the formation and growth of hyaline cartilage, its composition, structure and biomechanical properties. Special attention is given to materials development, scaffold designs, fabrication methods, and template-cell interactions, which are of great importance to the structure and functionality of the engineered tissue. PMID:26923076

  11. Chronic Inflammatory Periodontal Disease in Patients with Human Immunodeficiency Virus. Enfermedad periodontal inflamatoria crónica en pacientes infectados con el virus de inmunodeficiencia humana.

    Directory of Open Access Journals (Sweden)

    Iralys Benítez Guzmán

    2009-07-01

    Full Text Available Background: The Chronic Inflammatory Periodontal Disease is related with multiple risk factors. Those patients with human immunodeficiency virus have higher risk of presenting this disease and it is usually more serious in these cases. Objective: To describe the prevalence of Chronic Inflammatory Periodontal Disease in patients with HIV. Methods: Descriptive, observational, cross-sectional study including patients with HIV in Sancti Spiritus province. The occurrence of the disease was determined after the Periodontics Cuban Standards, and oral hygiene was assessed through the simplified oral hygiene index. Other variables were measured, such as smoking habits, T CD4+ lymphocyte counting and virus load. The independent association of each risk factor with the disease was determined through a logistic regression model. Results: The 56, 5 % of the 154 patients presented Chronic Inflammatory Periodontal Disease; 60 (39.0% gingivitis and 27 (17,5% periodontitis. Gingivitis was associated with poor oral hygiene (OR: 3,71 and periodontitis with smoking habit (OR: 5,20. The severe forms of periodontitis occurred mainly in patients with lymphocyte counting lower than 500 cells/mm3 . Conclusions: The prevalence of Chronic Inflammatory Periodontal Disease in patients with HIV in Sancti Spiritus province is linked to known risk factors such as smoking habits and oral hygiene.Fundamento: La enfermedad periodontal inflamatoria crónica es un trastorno relacionado con diversidad de factores de riesgo. Los pacientes infectados con el virus de inmunodeficiencia humana tienen mayor riesgo para padecerla y en ellos muchas veces se agrava.  Objetivo: Describir la prevalencia de la enfermedad periodontal inflamatoria crónica en pacientes infectados con el virus de inmunodeficiencia humana. Métodos: Estudio observacional

  12. Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model

    Science.gov (United States)

    Cheng, N-T.; Cui, Y-P.

    2016-01-01

    Objectives Recent studies have shown that systemic injection of rapamycin can prevent the development of osteoarthritis (OA)-like changes in human chondrocytes and reduce the severity of experimental OA. However, the systemic injection of rapamycin leads to many side effects. The purpose of this study was to determine the effects of intra-articular injection of Torin 1, which as a specific inhibitor of mTOR which can cause induction of autophagy, is similar to rapamycin, on articular cartilage degeneration in a rabbit osteoarthritis model and to investigate the mechanism of Torin 1’s effects on experimental OA. Methods Collagenase (type II) was injected twice into both knees of three-month-old rabbits to induce OA, combined with two intra–articular injections of Torin 1 (400 nM). Degeneration of articular cartilage was evaluated by histology using the Mankin scoring system at eight weeks after injection. Chondrocyte degeneration and autophagosomes were observed by transmission electron microscopy. Matrix metallopeptidase-13 (MMP-13) and vascular endothelial growth factor (VEGF) expression were analysed by quantitative RT-PCR (qPCR).Beclin-1 and light chain 3 (LC3) expression were examined by Western blotting. Results Intra-articular injection of Torin 1 significantly reduced degeneration of the articular cartilage after induction of OA. Autophagosomes andBeclin-1 and LC3 expression were increased in the chondrocytes from Torin 1-treated rabbits. Torin 1 treatment also reduced MMP-13 and VEGF expression at eight weeks after collagenase injection. Conclusion Our results demonstrate that intra-articular injection of Torin 1 reduces degeneration of articular cartilage in collagenase-induced OA, at least partially by autophagy activation, suggesting a novel therapeutic approach for preventing cartilage degeneration and treating OA. Cite this article: N-T. Cheng, A. Guo, Y-P. Cui. Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a

  13. Nutrición artificial en la insuficiencia intestinal: síndrome de intestino corto: Enfermedad inflamatoria intestinal Artificial nutrition in intestinal failure: short bowel syndrome. Intestinal inflammatory disease

    Directory of Open Access Journals (Sweden)

    T. Grau Carmona

    2005-06-01

    Full Text Available La resección intestinal amplia produce suficientes alteraciones como para requerir soporte nutricional especializado. Las medidas básicas de tratamiento, especial-mente en la fase aguda tras la resección intestinal o en presencia de complicaciones graves sobre pacientes con intestino corto, incluyen la repleción de fluidos y electro-litos y la instauración de soporte nutricional con el fin de prevenir la malnutrición. La nutrición enteral es el principal factor estimulador de la adaptación del intestino remanente. No obstante, su aplicación presenta dificultades en las fases agudas, por lo que los pacientes deben ser tratados frecuentemente con nutrición parenteral. La presencia de desnutrición puede ser también de importancia en los pacientes con enfermedad inflamatoria intestinal. El soporte nutricional está indicado en estos casos como tratamiento primario de la enfermedad, como tratamiento de la desnutrición o como tratamiento perioperatorio en los pacientes que requieren cirugía. A pesar de la patología digestiva, existen datos para recomendar la nutrición enteral como método inicial para el aporte de nutrientes en los pacientes que lo precisen.Large intestinal resection produces a sufficient number of impairments as to require specialized nutritional support. Basic treatment measures, especially during the acute phase after intestinal resection or in the presence of severe complications in patients with short bowel syndrome, include fluid and electrolytes reposition and nutritional support implementation in order to prevent hyponutrition. Enteral nutrition is the main stimulating factor for adaptation of the remaining bowel. However, its application has some difficulties during the acute phase, and thus patients must be frequently treated with parenteral nutrition. The presence of hyponutrition may be also important in patients with intestinal inflammatory disease. Nutritional support is indicated in these cases as the

  14. Efecto antiinflamatorio y antioxidante del extracto hidroalcohólico de Petiveria alliacea

    OpenAIRE

    César Zaa; Martha Valdivia; Álvaro Marcelo

    2013-01-01

    Los radicales libres y el daño oxidativo están relacionados con la muerte celular, siendo la peroxidación lipídica un mecanismo que lleva a la destrucción oxidativa de la membrana celular. Además, en procesos inflamatorios, uno de los primeros estadios es la permeabilidad vascular incrementada (formación del edema) seguido de la extravasación de los fluídos, migración de leucocitos al sitio dañado y liberación de proteínas pro-inflamatorias. Evaluamos el efecto antioxidante y antiinflamat...

  15. Eficacia del entrenamiento excéntrico en tendinopatía aquílea

    OpenAIRE

    Martínez Martínez, Daniel

    2013-01-01

    La tendinopatía aquilea se produce cuando se forman pequeños desgarros en las fibras que conforman el tendón. Independientemente de si la lesión es inflamatoria o degenerativa, o si el asiento de la lesión está en la inserción o en el cuerpo del tendón, un alto porcentaje de personas, hasta un 60%, que presenta una Tendinopatía de Aquiles tiene problemas de apoyo podal o de mala alineación de la extremidad inferior. No se sabe cual es mejor tratamiento para ella. Objetivo...

  16. Estudio de proteínas reguladoras del ciclo celular en psoriasis mediante matrices tisulares

    OpenAIRE

    Roncero Riesco, Mónica

    2013-01-01

    [ES] Antecedentes. La psoriasis es una enfermedad inflamatoria crónica caracterizada histológicamente por la hiperproliferación y la diferenciación anómala de los queratinocitos epidérmicos. Los queratinocitos sufren alteraciones en la regulación del ciclo celular que pueden ser demostrables mediante el estudio de expresión de sus proteínas reguladoras. Los patrones de expresión de estas proteínas podrían ser empleados como herramienta diagnóstica en casos donde la clínica, la histopa...

  17. Manejo clínico odontológico integral del paciente con síndrome de Sjögren: una propuesta

    OpenAIRE

    G. Sturla Rojas; F Romo Ormazábal; M.A. Torres-Quintana

    2014-01-01

    El síndrome de Sjögren (SS) es una enfermedad autoinmune, crónica e inflamatoria caracterizada por infiltración de células plasmáticas y linfocitos en las glándulas exocrinas, particularmente en las salivales y oculares. La patogénesis del SS está relacionada con factores inmunológicos, neurológicos, genéticos, virales y hormonales. La deficiente calidad y cantidad de saliva trae consecuencias devastadoras para la salud dental y bucal, alteraciones del esmalte, caries en las superficies denta...

  18. Modulación del receptor nicotínico por moléculas de relevancia clínica

    OpenAIRE

    Alberola Die, Armando; Soriano Úbeda, Sergi; Ivorra Pastor, Isabel; Morales Calderón, Andrés

    2013-01-01

    El receptor nicotínico de acetilcolina (nAChR) es el miembro mejor caracterizado de la superfamilia de canales iónicos activados por ligando (LGICs). Las disfunciones del nAChR se han relacionado con graves alteraciones fisiopatológicas del sistema nervioso, así como con alteraciones inflamatorias e inmunológicas y con el desarrollo de ciertos tipos de cáncer. Por ello, el conocimiento de las moléculas que modulan la función de este receptor, el estudio de sus mecanismos de acción y la diluci...

  19. Terapias alternativas para el tratamiento del lupus eritematoso sistémico. Revisión sistemática, Enero 2000 – Diciembre 2010

    OpenAIRE

    Suaza Moreno, Jesús Salvador

    2011-01-01

    Osler describió por primera vez las manifestaciones generales del Lupus Eritematoso Sistémico (LES) en 1895. Antes de este tiempo era considerada como una enfermedad cutánea desfigurante pero no mortal. En la actualidad se sabe que es una enfermedad inflamatoria crónica generalizada que sigue un curso de afectación a múltiples órganos, de causa aún desconocida. Existe dificultad para valorar la eficacia y efectividad de los medicamentos empleados en el tratamiento del LES, porque en la may...

  20. REGENERATION OF ARTICULAR CARTILAGE UNDER THE IMPLANTATION OF BONE MATRIX

    Directory of Open Access Journals (Sweden)

    Yuri M. Iryanov, Nikolay A. Kiryanov, Olga V. Dyuriagina , Tatiana Yu. Karaseva, Evgenii A. Karasev

    2015-07-01

    Full Text Available Background: The damage or loss of articular cartilage is costly medical problem. The purpose of this work – morphological analysis of reparative chondrogenesis when implanted in the area of the knee joint cartilage of granulated mineralized bone matrix. Material and Methods: The characteristic features of the knee cartilage regeneration studied experimentally in pubertal Wistar rats after modeling a marginal perforated defect and implantation of granulated mineralized bone matrix obtained according to original technology without heat and demineralizing processing into the injury zone. Results: This biomaterial established to have pronounced chondro- and osteoinductive properties, and to provide prolonged activation of reparative process, accelerated organotypical remodeling and restoration of the articular cartilage injured. Conclusion: The data obtained demonstrate the efficacy of МВМ in clinical practice for the treatment of diseases and injuries of the articular cartilage.

  1. Magnetic resonance imaging of articular cartilage at 3 tesla

    International Nuclear Information System (INIS)

    Smooth motor function can be maintained by articular cartilage. When the cartilage is injured, edema occurs, and as degeneration progresses, the cartilage thins and the cartilage matrix decreases. Magnetic resonance (MR) imaging allows noninvasive evaluation of these changes. Fat suppression proton density- and T2-weighted imaging are useful in the morphologic evaluation of articular cartilage. High resolution, 3-tesla MR imaging provides more detailed evaluation. Biochemical information from T2 mapping, T1ρ mapping, and delayed gadolinium-enhanced MR imaging of cartilage (dGEMRIC) is useful for early diagnosis of cartilage injury and evaluation of cartilage repair. The role of MR imaging in evaluating articular cartilage will increase in the future aging society. (author)

  2. A method for measuring contact pressures instantaneously in articular joints.

    Science.gov (United States)

    Inaba, H; Arai, M

    1989-01-01

    A method whereby instrumented pipes are inserted part of the way into articular cartilage from the underlying subchondral bone has been developed for measuring instantaneous contact pressures acting within articular joints. Contact pressures developed between two specimens cut from fresh cadaveric knee joints were measured with this technique and then subsequently with pressure-sensitive paper. Average contact pressures (load/contact area) were also calculated. Comparisons of the three sets of data show that contact pressures measured with the pressure pipe system are linearly related (p less than 0.001) to both the contact pressures measured with the pressure-sensitive paper and the calculated average contact pressures. PMID:2625431

  3. Experimental articular cartilage repair in the Göttingen minipig

    DEFF Research Database (Denmark)

    Christensen, Bjørn Borsøe; Foldager, Casper Bindzus; Olesen, Morten Lykke;

    2015-01-01

    BACKGROUND: A gold standard treatment for articular cartilage injuries is yet to be found, and a cost-effective and predictable large animal model is needed to bridge the gap between in vitro studies and clinical studies. Ideally, the animal model should allow for testing of clinically relevant...... treatments and the biological response should be reproducible and comparable to humans. This allows for a reliable translation of results to clinical studies.This study aimed at verifying the Göttingen minipig as a pre-clinical model for articular cartilage repair by testing existing clinical cartilage...

  4. Rotura aguda completa del ligamento colateral metacarpo-falángico radial del pulgar: una lesión grave infrecuente

    OpenAIRE

    Pellicer García, V.; Gutiérrez Carbonell, Pedro; Moril Peñalver, L.

    2012-01-01

    El ligamento colateral radial es el principal estabilizador articular contra las fuerzas de estrés en aducción de la articulación metacarpofalángica del pulgar. Esta lesión infrecuente, pasa a menudo desapercibida, desarrollándose una inestabilidad articular sintomática y, posteriormente, una artrosis secundaria. Aunque tradicionalmente se ha recomendado el tratamiento conservador de estas lesiones, estudios recientes han documentado mejores resultados funcionales cuando se realiza su repa...

  5. The epidemiology of extra-articular manifestations in ankylosing spondylitis

    DEFF Research Database (Denmark)

    Stolwijk, Carmen; Essers, Ivette; van Tubergen, Astrid;

    2015-01-01

    OBJECTIVE: To assess the incidence and risks of common extra-articular manifestations (EAMs), that is, acute anterior uveitis (AAU), psoriasis and inflammatory bowel disease (IBD), in patients with ankylosing spondylitis (AS) compared with population-based controls. METHODS: All incident patients...

  6. Microscopic and spectroscopic characterization of articular surfaces of joint replacement

    Czech Academy of Sciences Publication Activity Database

    Pavlova, Ewa; Dybal, Jiří; Schmidt, Pavel; Brunclíková, Miroslava; Pokorný, D.; Sosna, A.; Šlouf, Miroslav

    Praha : Československá mikroskopická společnost, 2006. s. 40. [Konference Mikroskopie 2006. 16.02.2006-17.02.2006, Nové Město na Moravě] R&D Projects: GA ČR GA106/04/1118 Keywords : UHMWPE * articular surfaces Subject RIV: CD - Macromolecular Chemistry

  7. Early micromovement of the Articular Surface Replacement (ASR) femoral component

    DEFF Research Database (Denmark)

    Penny, J O; Ding, M; Varmarken, Jens-Erik;

    2012-01-01

    Radiostereometric analysis (RSA) can detect early micromovement in unstable implant designs which are likely subsequently to have a high failure rate. In 2010, the Articular Surface Replacement (ASR) was withdrawn because of a high failure rate. In 19 ASR femoral components, the mean micromovement...

  8. The Effectiveness of Ultrasound-Guided Steroid Injection for Femoroacetabular Impingement: A Comparison between the Extra-Articular and Intra-Articular Approaches

    Energy Technology Data Exchange (ETDEWEB)

    Jeon, Chang Ho; Lee, Joon Woo [Dept. of Radiology, Seoul National University Bundang Hospital, Seongnam (Korea, Republic of)

    2013-03-15

    To assess the effectiveness of pain control using ultrasound-guided steroid injection by the extra-articular and intra-articular approaches to femoroacetabular impingement patients. From September through December 2010, 18 patients with clinical suspicion of femoroacetabular impingement syndrome underwent ultrasound-guided steroid and local anesthetics injection: a total of 20 cases, including 16 cases of ipsilateral and 2 cases of bilateral injection. Extra-articular or intra-articular approach was selected for each patient, randomly and alternately. Nine cases were performed by extra-articular approach and 11 cases were performed by intra-articular approach. Every patient was observed in the outpatient clinic and visual analogue scale (VAS) was taken and compared before and after the procedure in all patients. Pre-injection average VAS value of extra-articular approached cases was 5.22 {+-} 1.99 and post-injection average VAS value was 4.11 {+-} 1.96, which is statistically insignificant (p < 0.156). The average VAS value of intra-articular approached cases was decreased from 5.72 {+-} 2.15 to 2.91 {+-} 2.30 after injection, which is statistically significant (p < 0.006). Ultrasound guided intra-articular approached steroid and local anesthetics injection could be effective in controlling pain for patients with femoroacetabular impingement syndrome.

  9. Asociación HLA y artritis reumatoidea juvenil en busca de las bases moleculares dependiente del MHC /

    OpenAIRE

    Garavito de Egea, Gloria

    2004-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada Artritis reumatoidea Juvenil (ARJ) es una enfermedad inflamatoria crónica, autoinmune que afecta a mas de una articulación en lugar y numero. Es una de las enfermedades más comunes en la consulta pediátrica reumatológica y una de las menos estudiadas desde el punto de vista inmunogenetico. En la literatura se ha reportado varias asociaciones de (HLA) Antigenos de Leucocitos Humanos y ARJ con diferentes grupos étnicos, so...

  10. Parasitosis intestinal extrema en la infancia previa al desarrollo de enfermedades reumáticas inflamatorias/autoinmunes

    OpenAIRE

    F. Javier Jiménez-Balderas; Adolfo Camargo-Coronel; Juan O. Talavera; José Gutiérrez; Abraham Zonana-Nacach; Ernesto A. Jiménez-Balderas

    2008-01-01

    Objetivo. Investigar la asociación del antecedente de parasitosis intestinal extrema (PIE) durante la infancia enpacientes ahora adultos con enfermedades reumáticas/ autoinmunes (ERAI). Métodos. Se estudiaron 54 pacientes consecutivos con ERAI, (27 con espondilitis anquilosante 9 con artritis reumatoide, 19 con lupus eritematoso sistémico) y 54 controles sanos; 27 hombres y 27 mujeres. Todos los sujetos tenían padres que informaran de eventos PIE durante la infancia, previos al inicio de la E...

  11. Caracterización de las acciones protectoras del ácido oleanólico en modelos experimentales de patologías con base inflamatoria

    OpenAIRE

    Pereira Córdova Marcos, Cláudia Manuela

    2015-01-01

    La Esclerosis Múltiple y la Miocarditis son dos enfermedades autoinmunes que se deben a la alteración en la respuesta inmune donde el organismo no reconoce el propio de lo extraño. La Conjuntivitis Alérgica se debe a alteraciones de la respuesta inmune asociada a reacciones de hipersensibilidad y es una respuesta inmune exagerada a un agente inocuo. El ácido oleanólico (AO) es un compuesto natural que se encuentra en numerosas plantas entre las cuales el olivo y presenta propiedades: cardiopr...

  12. One intra-articular injection of hyaluronan prevents cell death and improves cell metabolism in a model of injured articular cartilage in the rabbit

    NARCIS (Netherlands)

    Jansen, Edwin J. P.; Ernans, Pieter J.; Douw, Conny M.; Guidemond, Nick A.; Van Rhijn, Lodewijk W.; Bulstra, Sjoerd K.; Kuijer, Roell

    2008-01-01

    The purpose of this study was to determine the effect of one intra-articular injection of hyaluronan on chondrocyte death and metabolism in injured cartilage. Twenty-three 6-month-old rabbits received partial-thickness articular cartilage defects created on each medial femoral condyle. In order to e

  13. Intra-Articular Polyacrylamide Hydrogel Injections Are Not Innocent

    OpenAIRE

    Murat Tonbul; Mujdat Adas; Taner Bekmezci; Ahmet Duran Kara

    2014-01-01

    Osteoarthritis is a chronic disorder characterized by joint cartilage degeneration with concomitant changes in the synovium and subchondral bone metabolism. Many conservative treatment modalities, one of which is intra-articular injections, have been described for the treatment of this disorder. Traditionally, hyaluranic acid and corticosteroids are the agents that have been used for this purpose. Recently, polyacrylamide hydrogels are being used widely. Biocompatibility, nonbioabsorbability,...

  14. Resurfacing Damaged Articular Cartilage to Restore Compressive Properties

    OpenAIRE

    Grenier, Stephanie; Donnelly, Patrick E; Gittens, Jamila; Torzilli, Peter A.

    2014-01-01

    Surface damage to articular cartilage is recognized as the initial underlying process causing the loss of mechanical function in early-stage osteoarthritis. In this study, we developed structure-modifying treatments to potentially prevent, stabilize or reverse the loss in mechanical function. Various polymers (chondroitin sulfate, carboxymethylcellulose, sodium hyaluronate) and photoinitiators (riboflavin, irgacure 2959) were applied to the surface of collagenase-degraded cartilage and crossl...

  15. Advances in the Surgical Management of Articular Cartilage Defects

    OpenAIRE

    Stein, Spencer; Strauss, Eric; Bosco, Joseph

    2013-01-01

    Objective: The purpose of this review is to gain insight into the latest methods of articular cartilage implantation (ACI) and to detail where they are in the Food and Drug Administration approval and regulatory process. Design: A PubMed search was performed using the phrase “Autologous Chondrocyte Implantation” alone and with the words second generation and third generation. Additionally, clinicaltrials.gov was searched for the names of the seven specific procedures and the parent company we...

  16. Engineering articular cartilage using newly developed carrageenan basedhydrogels

    OpenAIRE

    Popa, Elena Geta

    2014-01-01

    Articular cartilage holds specific functionality in the human body creating smooth gliding areas and allowing the joints to move easily without pain. However, due to its avascular nature and to the low metabolic activity of the constituent cells-the chondrocytes, cartilage has a low regenerative potential. The current surgical options to treat damaged cartilage are not long lasting and involve frequent revisions. Tissue engineering may provide an alternative approach for cartilage...

  17. Articular facets syndrome: diagnostic grading and treatment options

    OpenAIRE

    Misaggi, B.; Gallazzi, M.; Colombo, M; Ferraro, M.

    2009-01-01

    Approximately 80% of the adult population suffers from chronic lumbar pain with episodes of acute back pain. The aetiology of this disorder can be very extensive: degenerative scoliosis, spondiloarthritis, disc hernia, spondylolysis, spondylolisthesis and, in the most serious cases, neoplastic or infectious diseases. For several years, the attention of surgeons was focused on the articular facets syndrome (Lilius et al. in J Bone Joint Surg (Br) 71-B:681–684, 1998), characterised clinically b...

  18. Intra-articular Lidocaine Injection for Shoulder Reductions

    OpenAIRE

    Waterbrook, Anna L; Paul, Stephen

    2011-01-01

    Context: The shoulder is the most commonly dislocated joint, and shoulder dislocations are very common in sports. Many of these dislocations present to the office or training room for evaluation. Usual practice is an attempt at manual reduction without analgesia and then transfer to the emergency department if unsuccessful. The clinical efficacy of intra-articular lidocaine for reduction of anterior shoulder dislocations in the outpatient setting was examined. Evidence Acquisition: An OVID ME...

  19. FACTOR NUCLEAR κB (NF-κB): SIGNALOSOMA Y SU IMPORTANCIA EN ENFERMEDADES INFLAMATORIAS Y CÁNCER

    OpenAIRE

    Nancy P Echeverri R; Ismena Mockus S

    2008-01-01

    El factor nuclear κB (NF-κB) es un dímero constituido por proteínas de la familia Rel. El NF-κB se encuentra en el citoplasma unido a proteínas inhibidoras (IkB). Las IkB son fosforiladas por diferentes cinasas que hacen parte del signalosoma como las cinasas de IKKα e IKKP y el modulador esencial de NF-κB (NEMO), la proteína cinasa activadora de mitosis (MAPK o p38) y la cinasa inductora de NF-κB (NIK). Estas cinasas al ser activadas por señales dependientes de citocinas y luz ultravioleta, ...

  20. Influência de diferentes ângulos articulares obtidos na posição inicial do exercício pressão de pernas e final do exercício puxada frontal sobre os valores de 1RM Influencia en los diferentes ángulos articulares obtenidos en la posición inicial del ejercicio de presión de piernas y al final del ejercicio de puje frontal sobre los valores de 1RM The influence of different joint angles obtained in the starting position of leg press exercise and at the end of the frontal pull exercise on the values of 1RM

    Directory of Open Access Journals (Sweden)

    João Augusto Reis de Moura

    2004-08-01

    Full Text Available O teste de uma repetição máxima (1RM tem sido aplicado sobre várias circunstâncias e em diversos objetivos, sendo que variáveis potencialmente influenciadoras deste teste têm sido constantemente estudadas. Este estudo buscou avaliar a influência de diferentes ângulos na posição inicial de execução dos exercícios pressão de pernas e posição final do exercício puxada frontal sobre os resultados de 1RM. Para tal foram mensurados no teste de 1RM dos exercícios pressão de pernas e puxada frontal 20 sujeitos voluntários do sexo masculino (médias de idade 24,5 anos, estatura 1,75 metros e massa corporal de 72,0kg. Após consentimento de participação e a adaptação ao treinamento resistido com pesos, foi aplicado o teste de 1RM no exercício pressão de pernas em três diferentes ângulos de testagem na posição inicial (80º, 90º e 100º de flexão do joelho e também no exercício puxada frontal posição final (60º, 70º e 80º de flexão do cotovelo, sendo que cada ângulo foi testado em dias diferentes, porém com os dois exercícios. Os resultados indicam que as médias de 1RM para o exercício pressão de pernas são estatisticamente diferentes (F = 30,199; p = 0,000 entre si (post hoc de Tukey. Já para o exercício puxada frontal, embora existam diferenças, estas não foram estatisticamente significativas (F = 1,330; p = 0,281. Conclui-se que diferentes técnicas de execução dos exercícios que envolvam angulações diversas, principalmente nas posições iniciais destes, devem ser rigorosamente controladas, pois podem afetar a quilagem levantada.El test de Repetición Máxima (1RM ha sido aplicado en varias circunstancias y en diversos objetivos siendo que variable potencialmente influyentes en este test vienen siendo constantemente estudiadas. Este estudio buscó evaluar la influencia de diferentes ángulos en la posición final del ejercicio de presión de piernas y de puje frontal sobre los resultados de 1RM

  1. Colonies in engineered articular cartilage express superior differentiation.

    Science.gov (United States)

    Selvaratnam, L; Abd Rahim, S; Kamarul, T; Chan, K Y; Sureshan, S; Penafort, R; Ng, C L L

    2005-07-01

    In view of poor regeneration potential of the articular cartilage, in-vitro engineering of cartilage tissue offers a promising option for progressive joint disease. This study aims to develop a biologically engineered articular cartilage for autologous transplantation. The initial work involved determination of chondrocyte yield and viability, and morphological analysis. Cartilage was harvested from the knee, hip and shoulder joints of adult New Zealand white rabbits and chondrocytes were isolated by enzymatic digestion of the extra-cellular matrix before serial cultivation in DMEM/Ham's F12 media as monolayer cultures. No differences were noted in cell yield. Although chondrocytes viability was optimal (>93%) following harvest from native cartilage, their viability tended to be lowered on passaging. Chondrocytes aggregated in isogenous colonies comprising ovoid cells with intimate intracellular contacts and readily exhibited Safranin-O positive matrix; features typically associated with articular cartilage in-vivo. However, chondrocytes also existed concurrently in scattered bipolar/multipolar forms lacking Safranin-O expression. Therefore, early data demonstrated successful serial culture of adult chondrocytes with differentiated morphology seen in established chondrocyte colonies synthesizing matrix proteoglycans. PMID:16381284

  2. Effects of vimentin disruption on the mechanoresponses of articular chondrocyte.

    Science.gov (United States)

    Chen, Cheng; Yin, Li; Song, Xiongbo; Yang, Hao; Ren, Xiang; Gong, Xiaoyuan; Wang, Fuyou; Yang, Liu

    2016-01-01

    Human articular cartilage is subjected to repetitive mechanical loading during life time. As the only cellular component of articular cartilage, chondrocytes play a key role in the mechanotransduction within this tissue. The mechanoresponses of chondrocytes are largely determined by the cytoskeleton. Vimentin intermediate filaments, one of the major cytoskeletal components, have been shown to regulate chondrocyte phenotype. However, the contribution of vimentin in chondrocyte mechanoresponses remains less studied. In this study, we seeded goat articular chondrocytes on a soft polyacrylamide gel, and disrupted the vimentin cytoskeleton using acrylamide. Then we applied a transient stretch or compression to the cells, and measured the changes of cellular stiffness and traction forces using Optical Magnetic Twisting Cytometry and Traction Force Microscopy, respectively. In addition, to study the effects of vimentin disruption on the intracellular force generation, we treated the cells with a variety of reagents that are known to increase or decrease cytoskeletal tension. We found that, after a compression, the contractile moment and cellular stiffness were not affected in untreated chondrocytes, but were decreased in vimentin-disrupted chondrocytes; after a stretch, vimentin-disrupted chondrocytes showed a lower level of fluidization-resolidification response compared to untreated cells. Moreover, vimentin-disrupted chondrocytes didn't show much difference to control cells in responding to reagents that target actin and ROCK pathway, but showed a weaker response to histamine and isoproterenol. These findings confirmed chondrocyte vimentin as a major contributor in withstanding compressive loading, and its minor role in regulating cytoskeletal tension. PMID:26616052

  3. Influencia del entrenamiento del equilibrio con plataforma dinamométrica en artroplastia total de rodilla

    OpenAIRE

    Roig-Casasús, Sergio

    2015-01-01

    Introducción: Debido al en envejecimiento de la población y al aumento en la esperanza de vida, en la actualidad la artroplastia de rodilla es una de las cirugías más frecuentes en el primer mundo. Las causas más frecuentes del reemplazo protésico son la artrosis y la artritis reumatoidea. Dependiendo del dolor, la limitación articular y la impotencia funcional, el cirujano determina dicha cirugía. Gran parte del éxito de esta cirugía tanto a nivel motor como funcional depende en gran medida ...

  4. INTERNAL FIXATION OF INTRA ARTICULAR CALCANEUM FRACTURES USING LOCKING COMPRESSION PLATE

    OpenAIRE

    Neelakrishnan; Balamurugavel; Barathiselvan; Viswanathan

    2014-01-01

    INTRODUCTION: Calcaneum is the most frequently fractured tarsal bone. Historically intra articular calcaneum fractures treated non-operatively which led to increased morbidity due to in congruency of articular surface resulting in subtalar arthritis. With advent of CT scan, better implants and improved methods of fixation. Operative treatment has now become a standard method. AIM OF THE STUDY: To study the functional and radiological outcome of intra articular calcaneum fr...

  5. Efecto del tratamiento con atorvastatina sobre los marcadores de inflamación en la cirugía de revascularización coronaria con arteria mamaria

    OpenAIRE

    Parraza Díez, Naiara

    2012-01-01

    INTRODUCCIÓN Recientes estudios muestran que la respuesta inflamatoria que tiene lugar durante la cirugía vascular está lejos de ser duradera, encontrando un aumento de hasta 20veces la concentración de los marcadores de inflamación y siendo detectable este aumento en algunos de ellos hasta 24h después de la cirugía. Mediciones seriadas de diferentes marcadores de inflamación parecen ser útiles para cuantificar el grado de daño tisular, la invasividad del procedimiento y la detección temprana...

  6. Estudio del estado de salud oral y salival en relación con las complicaciones de diabéticos tipo 1

    OpenAIRE

    Hontanilla Estruch, Estela

    2014-01-01

    En la actualidad está reconocido que la patogénesis de la diabetes está muy influenciada por una activación del sistema inmune y por un bajo grado de inflamación. Las principales citoquinas que participan en la patogénesis de la diabetes son la IL-1, el TNF- , y la IL-6. Además, algunos estudios recientes han demostrado que la inflamación, y más concretamente las citoquinas inflamatorias, son determinantes en el desarrollo de las complicaciones microvasculares de la diabetes: neuropatía, reti...

  7. Esclerosis múltiple en una mujer fallecida por quemaduras en el incendio del domicilio Multiple sclerosis in a woman died by burns in a house fire

    OpenAIRE

    J. Lucena; M. Salguero; A. Rico; Blanco, M.; Marín, R; E. Barrero; F. Heredia

    2004-01-01

    La esclerosis múltiple (EM) o esclerosis en placas es la más común de las enfermedades inflamatorias desmielinizantes del SNC y el trastorno neurológico más incapacitante en los adultos jóvenes. Se caracteriza por la aparición de lesiones focales diseminadas en la sustancia blanca denominadas placas en las que lo más llamativo es la pérdida de la mielina (desmielinización) con preservación relativa de los axones. Es infrecuente que esta enfermedad entre en el campo de investigación médico-for...

  8. Extra-articular triplane fracture of the distal tibia: a case report

    International Nuclear Information System (INIS)

    The triplane fracture of the distal tibia is anatomically complex. It typically consists of a coronal fracture of the metaphysis, a transverse fracture of the physis, and a sagittal, intra-articular fracture of the epiphysis. We report an unusual variation of the triplane fracture which includes an extra-articular epiphyseal component involving the medial malleolus. This is an important variant to recognize because it does not disrupt the distal tibial articular surface. This lack of articular involvement allows for non-surgical management in contrast to the usual triplane fracture which often requires open reduction and internal fixation. (orig.)

  9. Uso de concentrados autólogos de plaquetas intraarticulares como coadyuvantes en el tratamiento quirúrgico de la rotura del ligamento cruzado anterior en una perra Use of intra-articular autologous platelet concentrates as coadjutants in the surgical treatment of a cranial cruciate ligament rupture in a bitch

    OpenAIRE

    RF Silva; CMF Rezende; JU Carmona

    2011-01-01

    La ruptura del ligamento cruzado anterior (RLCA) es uno de los principales problemas ortopédicos que producen cojera de los miembros posteriores en perros. A pesar de que este problema sea tratado quirúrgicamente el desarrollo y progresión de la osteoartritis son típicamente característicos. Se describe un caso de un perro que recibió inyecciones intraarticulares de concentrados autólogos de plaquetas (APCs) durante el posoperatorio después de la reparación quirúrgica de una RLCA. Los resulta...

  10. Efectividad y seguridad de la viscosuplementación con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA) para el tratamiento del dolor secundario a gonartrosis Efficacy and safety of single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) for gonarthrosis pain treatment

    OpenAIRE

    M.M. Monerris Tabasco; I. Martí Acebedo; G. Roca Amatria; R. M. Rincón Párraga; M. Hinojosa Zaguirre; Y. Jiménez Capel; D. Samper Bernal

    2012-01-01

    Objetivos: valorar la efectividad y seguridad de la inyección de dosis única de ácido hialurónico estabilizado de origen no animal (NASHA) para el tratamiento del dolor secundario a gonartrosis. Material y métodos: se han incluido un total de 37 pacientes afectos de gonartrosis diagnosticada previamente por el Traumatólogo/Reumatólogo en los que ha fracasado el tratamiento conservador y/o que no son tributarios de tratamiento quirúrgico. Se les ha efectuado una infiltración en dosis única de ...

  11. Reacción inflamatoria asociada a infiltración cosmética facial múltiple: A propósito de un caso Inflammatory reaction associated with multiple cosmetic facial infiltration: Report of a case

    OpenAIRE

    B Tejedor Gómez; J.C. Coca Meneses; J.C. Melendres Romero; A. Eguía del Valle; J. López Vicente; R. Martínez-Conde

    2010-01-01

    El uso de sustancias para el aumento de los tejidos blandos con fines cosméticos puede ocasionar la aparición de diferentes efectos adversos, entre los que se encuentran las reacciones inflamatorias tardías. Se presenta un caso clínico de una de estas reacciones en una paciente de 41 años de edad que había sido infiltrada 4 años antes en ambos surcos nasogenianos y glabelar con un gel de poliacrilamida y posteriormente con toxoide botulínico tipo A. Se discuten los principales aspectos clínic...

  12. Metabolic Effects of Avocado/Soy Unsaponifiables on Articular Chondrocytes

    Directory of Open Access Journals (Sweden)

    Louis Lippiello

    2008-01-01

    Full Text Available Avocado/soy unsaponifiable (ASU components are reported to have a chondroprotective effect by virtue of anti-inflammatory and proanabolic effects on articular chondrocytes. The identity of the active component(s remains unknown. In general, sterols, the major component of unsaponifiable plant material have been demonstrated to be anti-inflammatory in vitro and in animal models. These studies were designed to clarify whether the sterol content of ASU preparations were the primary contributors to biological activity in articular chondrocytes. ASU samples were analyzed by high pressure liquid chromatography (HPLC and GC mass spectrometry. The sterol content was normalized between diverse samples prior to in vitro testing on bovine chondrocytes. Anabolic activity was monitored by uptake of 35-sulfate into proteoglycans and quantitation of labeled hydroxyproline and proline content after incubation with labeled proline. Anti-inflammatory activity was assayed by measuring reduction of interleukin-1 (IL-1-induced synthesis of PGE2 and metalloproteases and release of label from tissue prelabeled with S-35.All ASU samples exerted a similar time-dependent up-regulation of 35-sulfate uptake in bovine cells reaching a maximum of greater than 100% after 72 h at sterol doses of 1–10 μg/ml. Non-collagenous protein (NCP and collagen synthesis were similarly up-regulated. All ASU were equally effective in dose dependently inhibiting IL-1-induced MMP-3 activity (23–37%, labeled sulfate release (15–23% and PGE2 synthesis (45–58%. Up-regulation of glycosaminoglycan and collagen synthesis and reduction of IL-1 effects in cartilage are consistent with chondroprotective activity. The similarity of activity of ASU from diverse sources when tested at equal sterol levels suggests sterols are important for biologic effects in articular chondrocytes.

  13. Biochemical analysis of normal articular cartilage in horses.

    Science.gov (United States)

    Vachon, A M; Keeley, F W; McIlwraith, C W; Chapman, P

    1990-12-01

    Articular cartilage specimens from the distal articular surface of 32 radiocarpal bones from 24 2- to 5-year-old horses were analyzed. The total collagen content was determined on the basis of the 4-hydroxyproline content, using a colorimetric method. A method for estimating the proportions of types-I and -II collagen by measuring spectrophotometric densities of specific cyanogen bromide peptide bands from mixtures of types-I and -II collagen on sodium dodecyl sulfate-polyacrylamide gels was used. The cyanogen bromide peptides representative of each collagen types-I and -II were identified. The peptide ratios were then computed for each of several standards of type-I and -II mixtures. A standard curve was derived from the correlation between these ratios and the corresponding proportions of type-II collagen in standard mixtures. Galactosamine and glucosamine content (hexosamines) were measured by ion chromatography. The galactosamine-to-glucosamine ratio, chondroitin sulfate and keratan sulfate values, and total glycosaminoglycan content were derived from the measured hexosamine content. The total collagen content averaged 556 mg/g (55.6 mg/100 mg) of tissue (dry weight, [dw]). Type-II collagen was the major collagen type in normal articular cartilage specimens. The ratio of the area under the alpha 1 (II)CB10 peak to the area under the alpha 1 (I)CB 7,8 + alpha 1 (II)CB11 peak was a second-order polynomial function of the proportion of type-II collagen in the specimens. The mean galactosamine and glucosamine content were 20.6 mg/g and 7.9 mg/g (dw), respectively. The mean galactosamine-to-glucosamine ratio was 3.74 +/- 0.62.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2085215

  14. Pediatric and adolescent intra-articular fractures of the calcaneus

    Directory of Open Access Journals (Sweden)

    Marcel Dudda

    2013-06-01

    Full Text Available Calcaneal fractures in childhood are very rare, whereas particularly intra-articular displaced fractures are not typical in skeletally immature children. Various techniques of osteosynthesis have been described. This study aimed to determine clinical and radiological outcome after surgical treatment of intra-articular calcaneal fractures. Fourteen intra-articular fractures of the calcaneus were included in this retrospective study. Eleven children (2 girls and 9 boys aged 6-16 years (average age 11.5 years underwent surgical treatment. One child sustained a Type II open fracture of both calcanei. All injuries occurred after a high-energy trauma; 3 patients had multiple additional fractures. The clinical and radiological postoperative follow up was an average 44 months. In 4 cases, a reduction through a minimally invasive approach and fixation with K-wires or screws could be achieved. Eleven fractures were treated with open reduction and internal fixation with plate osteosynthesis, K-wires or screws. In one case with open fractures of both heel bones, an additional external fixator was applied. The surgical treatment approach adopted enabled the pre-operative Boehler’s angle (average 16° to be improved to an average 30°. In all cases, except for the patient with open fractures, a good functional result and outcome could be achieved. In calcaneal fractures in childhood, anatomical reduction is the determining factor, as in fractures in adults, whereas the surgical technique seems to have no influence on clinical outcome in children. The wound healing problems that have often been described were not observed in this age group.

  15. Analgesia intra-articular com sulfato de morfina em equinos

    OpenAIRE

    Nichele, Murilo

    2013-01-01

    Resumo: a resposta da articulação eqüina a uma injúria simples representa à soma dos processos fisiológicos normais direcionados a reparação das lesões originadas nas artropatias. Tais lesões podem limitar em caráter temporário ou definitivo a utilização dos eqüinos atletas em cada uma das modalidades a que se destinam. Neste experimento foram utilizados 15 eqüinos com idades variando de cinco a quatorze anos, apresentando afecções articulares. Os animais foram submetidos a artrocentese (arti...

  16. Listeria monocytogenes septic arthritis following intra-articular yttrium-90 therapy.

    OpenAIRE

    Wilson, A P; Prouse, P J; Gumpel, J. M.

    1984-01-01

    Listeria monocytogenes is a rare cause of septic arthritis, which usually occurs in a host compromised by systemic illness. Intra-articular irradiation with yttrium-90 is generally free of complication. We report a case of intra-articular sepsis of the knee joint by Listeria monocytogenes acquired under unusual circumstances.

  17. CLINICAL OUTCOME OF INTRA - ARTICULAR DISTAL RADIUS FRACTURES TREATED WITH PLATE AND SCREWS

    OpenAIRE

    Girish; Hosangadi; Suresh; Suryakanth

    2015-01-01

    BACKGROUND : Incidence of fractures of distal radius are increasing due to more geriatric population and road traffic accidents. The fundamental goal of distal radius fractures treatment is restoration of normal or near normal alignment and articular congruity. Restoration of the anatomy and articular surface may prevent the onset of arthritis ...

  18. A biphasic finite element study on the role of the articular cartilage superficial zone in confined compression

    OpenAIRE

    Guo, Hongqiang; Maher, Suzanne A; Torzilli, Peter A.

    2014-01-01

    The aim of this study was to investigate the role of the superficial zone on the mechanical behavior of articular cartilage. Confined compression of articular cartilage was modeled using a biphasic finite element analysis to calculate the one-dimensional deformation of the extracellular matrix (ECM) and movement of the interstitial fluid through the ECM and articular surface. The articular cartilage was modeled as an inhomogeneous, nonlinear hyperelastic biphasic material with depth and strai...

  19. Extra-articular hip impingement: a narrative review of the literature

    Science.gov (United States)

    Cheatham, Scott W.

    2016-01-01

    There is growing subgroup of patients with poor outcomes after hip arthroscopy for intra-articular pathology suggesting unrecognized cause(s) of impingement may exist. Extra-articular hip impingement (EHI) is an emerging group of conditions that have been associated with intra-articular causes of impingement and may be an unrecognized source of pain. EHI is caused by abnormal contact between the extra-articular regions of the proximal femur and pelvis. This review discusses the most common forms for EHI including: central iliopsoas impingement, subspine impingement, ischiofemoral impingement, and greater trochanteric-pelvic impingement. The clinical presentation of each pathology will be discussed since EHI conditions share similar clinical features as the intra-articular pathology but also contain some unique characteristics. PMID:27069266

  20. Secondary knee instability caused by fracture of the stabilizing insert in a dual-articular total knee

    DEFF Research Database (Denmark)

    Boesen, Morten P; Jensen, Tim Toftgaard; Husted, Henrik

    2004-01-01

    A case of a fractured polyethylene stabilizing insert causing secondary knee instability in a Dual-articular total knee arthroplasty (TKA) is presented. A 65-year-old woman who underwent surgery with a Dual-articular TKA 4 years earlier had a well-functioning prosthesis until a fall, after which......-articular knee....

  1. Outcome of ACL Reconstruction and Concomitant Articular Injury Treatment

    Directory of Open Access Journals (Sweden)

    Seyed Mohammad Tahami

    2015-09-01

    Full Text Available Background: Articular cartilage injuries are a common clinical problem at the time of ACL reconstruction with an incidence rate of 16-46%. Good results of ACL reconstruction combined with the treatment of chondral lesions have been published in some studies. Method: After statistical analysis 30 patients were selected and divided in 2 groups. TheFfirst group consisted of 15 patients wite isolated ACL tear without any other concomitant injuries and the second group consisted of 15 patients with ACL tear and concomitant high grade (grade 3 or 4 of outerbridge classification contained articular cartilage injuries during arthroscopy. Group 1 underwent ACL reconstruction and group 2 underwent ACL reconstruction combined with chondroplasty via the drilling and microfracture technique. For each patient the Lysholm knee score questionnaire was completed before surgery, 6 months and 1 year after surgery. Results: The mean Lysholm knee score in both groups improves: 9.6 points after 6 months and 16.06 points after 1 year in group 1 and 23.26 points after 6 months and 30.66 after 1 year in group 2, whict was statistically significant (Pvalue

  2. Delivering Agents Locally into Articular Cartilage by Intense MHz Ultrasound

    Science.gov (United States)

    Nieminen, Heikki J.; Ylitalo, Tuomo; Suuronen, Jussi-Petteri; Rahunen, Krista; Salmi, Ari; Saarakkala, Simo; Serimaa, Ritva; Hæggström, Edward

    2015-01-01

    There is no cure for osteoarthritis. Current drug delivery relies on systemic delivery or injections into the joint. Because articular cartilage (AC) degeneration can be local and drug exposure outside the lesion can cause adverse effects, localized drug delivery could permit new drug treatment strategies. We investigated whether intense megahertz ultrasound (frequency: 1.138 MHz, peak positive pressure: 2.7 MPa, Ispta: 5 W/cm2, beam width: 5.7 mm at −6 dB, duty cycle: 5%, pulse repetition frequency: 285 Hz, mechanical index: 1.1) can deliver agents into AC without damaging it. Using ultrasound, we delivered a drug surrogate down to a depth corresponding to 53% depth of the AC thickness without causing histologically detectable damage to the AC. This may be important because early osteoarthritis typically exhibits histopathologic changes in the superficial AC. In conclusion, we identify intense megahertz ultrasound as a technique that potentially enables localized non-destructive delivery of osteoarthritis drugs or drug carriers into articular cartilage. PMID:25922135

  3. Láser de baja potencia en el tratamiento de las calcificaciones de hombro Low power laser in the treatment of shoulder calcifications

    OpenAIRE

    A. Hernández Díaz; B. M. González Méndez; A. Orellana Molina; J.L. Martín Gil; J. Berty Tejeda

    2009-01-01

    Introducción: La artropatía o enfermedad por depósito de cristales es la entidad en la que el factor desencadenante de la respuesta inflamatoria es la presencia de microcristales en las estructuras articulares, pudiendo conducir con el tiempo a la lesión articular. No necesariamente se asocia a manifestaciones clínicas, y frecuentemente es un hallazgo radiológico casual. Objetivos: Se evaluó la eficacia del láser de baja potencia en pacientes con calcificaciones periarticulares de hombro con ...

  4. Tratamiento del dolor en la artritis reumatoide fundamentado en medicina basada en la evidencia Pain treatment in rheumatoid arthritis and evidence-based medicine

    Directory of Open Access Journals (Sweden)

    F. Neira

    2006-11-01

    , ciclosporina, sales de oro, azatioprina, infliximab, leflunomida y ciclofosfamida. La combinación de uno o más son eficaces y no más tóxicos que por separado. Los glucocorticoides a dosis bajas disminuyen la evolución del daño articular, no deben ser recomendados de rutina (R B. La infiltración articular con corticoides puede ser útil en el tratamiento de la AR. Se utiliza concomitantemente la administración de calcio, vitamina D y bifosfonatos (R B. El tratamiento quirúrgico está indicado cuando el dolor no mejora con medidas médicas y hay pérdida de función. Entre las complicaciones de la AR se encuentran: síndrome del túnel del carpo, vasculitis reumatoide, ataque de la región cervical y artritis séptica. No se deben olvidar las medidas nutricionales, terapia ocupacional (NE I, ejercicios, protección de las articulaciones y psicoterapia (NE I.The objective has been the elaboration of a practical document, based on the best available scientific evidence, that allows physicians to adopt adequately founded diagnostic techniques and effective treatment in Rheumatoid Arthritis (RA. A systematic search in Internet has been made, using the term "rheumatoid arthritis" and "artritis reumatoide", in different groups of elaboration and storage of clinical practice quides: National Guideline Clearinghouse HTTP://www.guideline.gov/compares/compares.aspx, CMA infobase, Primary Care Clinical Practice Guidelines and Fisterra - Directory of Clinical Guides in Spanish. Guides of clinical practice (GPC based in the evidence, meta-analysis and articles of greater relevance have been reviewed. RA is an inflammatory poliarthritis of undetermined aetiology, usually involving peripheral joints, with a symmetrical distribution. It affects functional and work capacity and increases mortality. The usual symptoms are arthralgia, morning stiffness, fatigue, weight loss and fever. It is considered that RA is present when 4 of the following 7 criteria are observed (American Rheumatism

  5. Efectos del tratamiento con anti-TNF-α, infliximab, sobre la resistencia insulínica, adipocinas (visfatina, leptina, adiponectina, resistina y apelina) y angiopoyetina-2 en pacientes con espondilitis anquilosante

    OpenAIRE

    Miranda Filloy, José Alberto

    2014-01-01

    RESUMEN: La Espondilitis Anquilosante (EA) es una enfermedad inflamatoria crónica que afecta fundamentalmente a la columna vertebral produciendo sacroileítis. Estos pacientes presentan una aterogénesis acelerada y resistencia insulínica, lo que favorece la disfunción endotelial e incrementa el riesgo cardiovascular. Hemos documentado que la infusión del anti-TNF-α infliximab en pacientes no diabéticos con EA mejora la sensibilidad insulínica y disminuye las concentraciones séricas de angio...

  6. Estudio del engrosamiento pleural residual en los derrames pleurales paraneumónicos y empiemas y su asociación con los marcadores de actividad neutrofílica

    OpenAIRE

    Soriano Sánchez, Teresa

    2009-01-01

    El derrame pleural paraneumónico es una causa frecuente de derrame pleural exudado. En la fisiopatología de los DP paraneumónicos se han implicado mecanismos inflamatorios y de alteración en el equilibrio de la fibrinolisis pleural. La respuesta inflamatoria pleural, iniciada por el mesotelio, provoca un aumento de la permeabilidad vascular y la liberación de mediadores inflamatorios, que favorecerá la formación de derrame pleural exudado y la invasión del espacio pleural por células inflamat...

  7. Caracterización del papel de los receptores de TNF en inflamación usando el pez cebra como modelo= Modelling the impact of TNF receptors in inflammation using the zebrafish.

    OpenAIRE

    Candel Camacho, Sergio

    2013-01-01

    INTRODUCTION: La psoriasis es una enfermedad inflamatoria crónica de la piel que afecta a millones de personas. Aunque en ratón no existen modelos de psoriasis, la facilidad para obtener muestras de piel de pacientes ha facilitado el estudio de las vías de señalización implicadas en la enfermedad, mostrando la importancia del sistema inmune en su desarrollo. Algunas terapias que utilizan anticuerpos específicos contra varias citoquinas, incluyendo TNFα, IL-23 y IL-17, son prometedoras, pe...

  8. Historias del arte y experiencias pedagógicas

    OpenAIRE

    Muñoz Cobeñas, Leticia Amelia

    2012-01-01

    El presente trabajo intenta articular la experiencia pedagógica con reflexiones en torno a la historia del arte, su renovación teórica y el acercamiento a diferentes mundos empíricos de las llamadas obras de arte. Desde la cátedra Epistemología de las ciencias sociales de la Facultad de Bellas Artes hemos reconocido los aportes interdisciplinares en la definición de una historia del arte que renueva e incorpora nuevas problemáticas y otros objetos de estudio surgidos al interior del propio...

  9. Granulocitoaféresis en la enfermedad inflamatoria intestinal: Eficacia a 32 semanas con protocolo de inducción y sesiones de mantenimiento Granulocytapheresis in inflamatory bowel disease: Efficacy of an induction plus maintenance sessions protocol at 32 weeks

    Directory of Open Access Journals (Sweden)

    F. J. Fernández Pérez

    2007-11-01

    Full Text Available Introducción: la granulocitoaféresis (GCAF retira de la circulación granulocitos-monocitos activados, modificando el pool circulante e induciendo una reducción en la inflamación intestinal. Objetivo: valorar la eficacia de la GCAF en la enfermedad inflamatoria intestinal (EII mediante sesiones de inducción y mantenimiento. Material y método: análisis retrospectivo en pacientes con EII activa corticodependiente y corticorrefractaria. Aplicamos 5 sesiones de inducción en colitis ulcerosa (CU y 7 en enfermedad de Crohn (EC y 1 sesión mensual hasta semana 32. Evaluamos indices clínicos de actividad y empleo de corticoides. Resultados: incluimos a 18 pacientes (10 CU, 8 EC, 10 de ellos corticodependientes y 8 corticorrefractarios. Catorce pacientes eran refractarios y 4 intolerantes a inmunosupresores (IS. No completaron la inducción 2-CU (brotes graves y 1-EC (secundarismos. Abandonaron el mantenimiento 1-CU y 3-EC. De aquellos que completaron inducción alcanzaron respuesta o remisión el 87,5% de las CU (2 y 5 pacientes, y el 71,4% de EC (1 y 4 pacientes respectivamente. Estos resultados a 32 semanas eran del 75% en CU (3 y 3 pacientes y del 42,8% en EC (1 y 2 pacientes respectivamente. De los que completaron la inducción, suprimieron corticoides el 14,2% de EC por el 62,5% de CU (25% de estas en remisión y 37,5% en respuesta. Registramos 2 secundarismos graves (tromboflebitis y síncope. Ninguna CU que completó inducción sufrió colectomía tras 97,6 (72-128 semanas de seguimiento. Conclusiones: tanto CU como EC responden bien a inducción con GCAF pero mientras la CU mantiene tras 32 semanas tasas similares de respuesta-remisión (87,5 vs. 75% casi 1/3 de los pacientes con EC recaen tras alcanzar respuesta. La granulocitoaféresis es una alternativa de tratamiento para inducir y mantener remision en CU, ahorrando corticoides, pero en la EC se precisa una adecuada selección de pacientes y un esquema de mantenimiento aún por

  10. Initial approach of patients admitted to third level hospitals with systemic inflamatory response syndrome Enfoque inicial de los pacientes admitidos a hospitales de tercer nivel con síndrome de respuesta inflamatoria sistémica (SRIS

    Directory of Open Access Journals (Sweden)

    Fabián Alberto Jaimes Barragán

    2000-04-01

    . Laboratory requests and microbiological studies did not in every case correlate with the initial diagnosis and the empirical antibiotic therapy. Objetivo: conocer el enfoque inicial de los pacientes con diagnóstico de síndrome de respuesta inflamatoria sistémica de origen infeccioso (SRIS en unidades de urgencias. Diseño: estudio observacional analítico en una cohorte concurrente. Lugar de estudio: servicios de urgencias del Hospital Universitario San Vicente de Paúl (HUSVP y el Hospital General de Medellín Luz Castro de Gutiérrez (HGM. Pacientes: admitidos por urgencias con SRIS de etiología no traumática entre agosto de 1998 y marzo de 1999, de edad igual o superior a 14 años, y con sospecha de infección como uno de los principales diagnósticos de admisión. Mediciones: descripción de la frecuencia de enfermedades asociadas, factores de riesgo y exploración física básica, determinación y utilidad de ayudas diagnósticas más usadas; y asociación entre foco infeccioso, microbiología, uso previo de antibióticos y antibioterapia empírica inicial en la admisión. Se utilizaron Chi cuadrado o prueba exacta de Fisher para la comparación de proporciones. Resultados: fueron admitidos 502 pacientes. Los principales antecedentes fueron EPOC (21.5% y trauma o cirugía previa (18.7%. La toma de signos vitales se determinó de la siguiente forma: frecuencia cardíaca en 100%, frecuencia respiratoria en 94.8%, presión arterial en 99.2%, temperatura en 80.3% y escala de Glasgow en 75.7% de los pacientes. Las solicitudes de laboratorio fueron: recuento de leucocitos en 98.4%, radiografía de tórax en 71.1%, recuento de plaquetas en 94.4% y creatinina en 89% de pacientes. En 26.5% de los pacientes no se solicitó ningún tipo de cultivo; en los restantes los más solicitados fueron los hemocultivos en 48.8% del total de la cohorte, de los cuales hubo crecimiento en 19.2% de las muestras. En 22.3% de los pacientes había habido consumo previo de antibióticos y

  11. Enfermedades articulares y uveítis Articular diseases and uveitis

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    J.M. Benítez del Castillo

    2008-01-01

    Full Text Available La inflamación ocular es una manifestación clínica frecuente de múltiples enfermedades sistémicas autoinmunes, siendo de gran relevancia en las espondiloartropatías. Dentro del grupo de las espondiloartropatías existen diferentes entidades clínicas, asociándose a diferentes patrones de uveítis. Se han definido una serie de patrones discriminativos que relacionan formas concretas de uveítis con determinadas enfermedades sistémicas u oculares. La uveítis anterior aguda unilateral recidivante es la más frecuente en las espondiloartropatías, y puede ser la forma de inicio de una espondiloartropatía no diagnosticada previamente. La colaboración entre oftalmólogos y reumatólogos o internistas es fundamental para el correcto manejo y tratamiento de estos pacientes.Ocular inflammation is a common clinical manifestation related to several autoimmune systemic disorders, specially spondyloarthropaties. In this group, there are different clinical diseases that are related to special uveitic patterns. Several discriminative patterns have been defined that closely link uveitis with certain systemic or ophthalmic diseases. Unilateral recurrent anterior acute uveitis is the most frequent form of uveitis related to spondyloarthropaties, and is sometimes the initial manifestation of an undiagnosed spondyloarthropaty. The collaboration of ophthalmologists, rheumatologists and internal medicine specialists is very important for the correct management and treatment of these patients.

  12. Articular cartilage repair and the evolving role of regenerative medicine

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    Pieter K Bos

    2010-10-01

    Full Text Available Pieter K Bos1, Marloes L van Melle1, Gerjo JVM van Osch1,21Department of Orthopaedic Surgery, Erasmus MC, Rotterdam, the Netherlands; 2Department of Otorhinolaryngology, Erasmus MC, Rotterdam, the NetherlandsAbstract: Among the growing applications of regenerative medicine, clinical articular cartilage repair has now been used for 2 decades and forms a successful example of translational medicine. Cartilage is characterized by a limited intrinsic repair capacity following injury. Articular cartilage defects cause symptoms, are not spontaneously repaired, and are generally believed to result in early osteoarthritis. Marrow stimulation techniques, osteochondral transplantation, and cell-based therapies, such as autologous chondrocyte implantation (ACI and use of mesenchymal stem cells (MSCs, are used for tissue regeneration, symptom relief, and prevention of further joint degeneration. The exact incidence of cartilage defects and the natural outcome of joints with these lesions are unclear. Currently available cartilage repair techniques are designed for defect treatment in otherwise healthy joints and limbs, mostly in young adults. The natural history studies presented in this review estimated that the prevalence of cartilage lesions in this patient group ranges from 5% to 11%. The background and results from currently available randomized clinical trials of the three mostly used cartilage repair techniques are outlined in this review. Osteochondral transplantation, marrow stimulation, and ACI show improvement of symptoms with an advantage for cell-based techniques, but only a suggestion that risk for joint degeneration can be reduced. MSCs, characterized by their good proliferative capacity and the potential to differentiate into different mesenchymal lineages, form an attractive alternative cell source for cartilage regeneration. Moreover, MSCs provide a regenerative microenvironment by the secretion of bioactive factors. This trophic activity

  13. Estructuras articulares, funcionales y anatómicas en la técnica de rotura de poder en el Taekwon-do

    OpenAIRE

    Bulens, Marlene

    2013-01-01

    El objetivo de la siguiente ponencia, es examinar aspectos anatómicos-funcionales y biomecánicos necesarios para lograr un correcto gesto técnico de la muñeca y de la mano, durante el desarrollo de la técnica de rotura de poder con golpe de puño en el Taekwon-do que conlleva a una excesiva fuerza de compresión articular que resiste la muñeca y la mano además del constante ajuste de la técnica para reestablecer la estabilidad. Hay tensiones musculares producidas por los músculos del antebra...

  14. Contact mechanics of articular cartilage layers asymptotic models

    CERN Document Server

    Argatov, Ivan

    2015-01-01

    This book presents a comprehensive and unifying approach to articular contact mechanics with an emphasis on frictionless contact interaction of thin cartilage layers. The first part of the book (Chapters 1–4) reviews the results of asymptotic analysis of the deformational behavior of thin elastic and viscoelastic layers. A comprehensive review of the literature is combined with the authors’ original contributions. The compressible and incompressible cases are treated separately with a focus on exact solutions for asymptotic models of frictionless contact for thin transversely isotropic layers bonded to rigid substrates shaped like elliptic paraboloids. The second part (Chapters 5, 6, and 7) deals with the non-axisymmetric contact of thin transversely isotropic biphasic layers and presents the asymptotic modelling methodology for tibio-femoral contact. The third part of the book consists of Chapter 8, which covers contact problems for thin bonded inhomogeneous transversely isotropic elastic layers, and Cha...

  15. Intra-Articular Polyacrylamide Hydrogel Injections Are Not Innocent

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    Murat Tonbul

    2014-01-01

    Full Text Available Osteoarthritis is a chronic disorder characterized by joint cartilage degeneration with concomitant changes in the synovium and subchondral bone metabolism. Many conservative treatment modalities, one of which is intra-articular injections, have been described for the treatment of this disorder. Traditionally, hyaluranic acid and corticosteroids are the agents that have been used for this purpose. Recently, polyacrylamide hydrogels are being used widely. Biocompatibility, nonbioabsorbability, and anti-infectious effect obtained by silver addition made polyacrylamide hydrogels more popular. In this paper, we present a case and the method of our management, in whom host tissue reaction (foreign body granuloma, edema, inflammation, and redness induration has been observed, as the first and unique adverse effect reported in the literature.

  16. Immortalization of human articular chondrocytes and induction of their phenotype

    Institute of Scientific and Technical Information of China (English)

    何清义; 李起鸿; 杨柳; 许建中

    2003-01-01

    Objective To immortalize human articular chondrocytes (HACs) using gene transfection and to maintain stable phenotype of transformed HACs after induction.Methods HACs were transfected with the retroviral vector pLXSN encoding human papillomavirus 16E7 (HPV16E7), and the transformed clones were sorted and proliferated. Karyotype analysis, clone forming tests and nude mice tumor forming tests were applied to check the characteristics of the transformation. Type Ⅱ collagen of transformed chondrocytes was inducted with free serum medium (FSM) supplemented with nutridoma-sp and ascorbate. Results Immortalized HACs were isolated with fifty passages achieved. The HPV16E7 transformed cells were confirmed to be benign. Induction of FSM with nutridoma-sp and ascorbate promoted type Ⅱ collagen of transformed chondrocytes to the high levels of normal chondrocytes. Conclusion HACs transformed with HPV16E7 survive for long periods in vitro, and type Ⅱ collagen can maintain stability after induction.

  17. Novel aspects to the structure of rabbit articular cartilage

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    ap Gwynn I.

    2002-12-01

    Full Text Available Applying cryo and modified chemical preparation techniques, mainly for scanning electron microscopy, revealed entirely new aspects to the structure of the radial zone of rabbit tibial plateau articular cartilage. The aggrecan component of the extracellular matrix was contained radially in columns, each with a diameter of 1-3mm, by a tightly packed matrix of collagen fibrils. The collagen fibrils were arranged radially, some straight and others in an opposed spiral arrangement, with regularly repeating patterns. This organization existed in the regions surrounding the columns of chondrocytes, known as chondrons. The load bearing property of the tissue was explained by the directed flow and containment of the interstitial fluid, modulated by the protein-carbohydrate complexes, along these collagen bounded tubular structures. The reason why such a structure has not been described previously may be that it is not retained by aldehyde fixation followed by dehydration, the method commonly used for tissue preparation for electron microscopy.

  18. CT dose optimisation and reduction in osteo-articular disease

    International Nuclear Information System (INIS)

    With an improvement in the temporal and spatial resolution, computed tomography (CT) is indicated in the evaluation of a great many osteo-articular diseases. New exploration techniques such as the dynamic CT and CT bone perfusion also provide new indications. However, CT is still an irradiating imaging technique and dose optimisation and reduction remains primordial. In this paper, the authors first present the typical doses delivered during CT in osteo-articular disease. They then discuss the different ways to optimise and reduce these doses by distinguishing the behavioural factors from the technical factors. Among the latter, the optimisation of the milli-amps and kilo-voltage is indispensable and should be adapted to the type of exploration and the morpho-type of each individual. These technical factors also benefit from recent technological evolutions with the distribution of iterative reconstructions. In this way, the dose may be divided by two and provide an image of equal quality. With these dose optimisation and reduction techniques, it is now possible, while maintaining an excellent quality of the image, to obtain low-dose or even very low-dose acquisitions with a dose sometimes similar that of a standard X-ray assessment. Nevertheless, although these technical factors provide a major reduction in the dose delivered, behavioural factors, such as compliance with the indications, remain fundamental. Finally, the authors describe how to optimise and reduce the dose with specific applications in musculoskeletal imaging such as the dynamic CT, CT bone perfusion and dual energy CT. (authors)

  19. Partial rotator cuff injury in athletes: bursal or articular?

    Directory of Open Access Journals (Sweden)

    Cassiano Diniz Carvalho

    2015-08-01

    Full Text Available ABSTRACTA painful shoulder is a very common complaint among athletes, especially in the case of those in sports involving throwing. Partial lesions of the rotator cuff may be very painful and cause significant functional limitation to athletes' sports practice. The incidence of partial lesions of the cuff is variable (13-37%. It is difficult to make the clinical and radiological diagnosis, and this condition should be borne in mind in the cases of all athletes who present symptoms of rotator cuff syndrome, including in patients who are diagnosed only with tendinopathy. OBJECTIVE: To evaluate the epidemiological behavior of partial lesions of the rotator cuff in both amateur and professional athletes in different types of sports. METHODS: We evaluated 720 medical files on athletes attended at the shoulder service of the Discipline of Sports Medicine at the Sports Traumatology Center, Federal University of São Paulo. The majority of them were men (65%. Among all the patients, 83 of them were diagnosed with partial lesions of the rotator cuff, by means of ultrasonography or magnetic resonance, or in some cases using both. We applied the binomial test to compare the proportions found. RESULT: It was observed that intra-articular lesions predominated (67.6% and that these occurred more frequently in athletes in sports involving throwing (66%. Bursal lesions occurred in 32.4% of the athletes, predominantly in those who did muscle building (75%. CONCLUSION: Intra-articular lesions are more frequent than bursal lesions and they occur predominantly in athletes in sports involving throwing, while bursal lesions were more prevalent in athletes who did muscle building.

  20. Extra-Articular Manifestations of Rheumatoid Arthritis, Now

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    Paloma Vela

    2014-06-01

    Full Text Available Rheumatoid arthritis (RA is a chronic systemic inflammatory disease, characterised by polyarthritis and extra-articular organ disease, including rheumatoid nodules, ophthalmologic manifestations, cardiopulmonary disease, vasculitis, neuropathy, glomerulonephritis, Felty’s syndrome, and amyloidosis. Extra-articular manifestations of RA (ExRA occur in 17.8–40.9% of RA patients, 1.5–21.5% of them presenting as severe forms and usually associated with increased morbidity and mortality. They can develop at any time during the course of the disease, even in the early stages, and are associated with certain predisposing factors, such as the presence of rheumatoid factor, smoking, and long-standing severe disease. Rheumatoid nodules, the most common ExRA, have been found to be associated with the development of severe features, such as vasculitis, rheumatoid lung disease, pericarditis, and pleuritis, especially in those patients who develop them within 2 years from RA diagnosis. There is no uniformity in the definition of the term ExRA, which limits comparability between different studies. Several recent surveys suggest a lower frequency, probably due to a better control of disease activity. Diagnosis of ExRA is a challenge for clinicians, given its variable and complex presentation, and the lack of specific diagnostic tests; it must be based on clinical recognition and exclusion of other causes of the signs and symptoms. Furthermore, management continues to be difficult with a bad prognosis in many conditions. This article reviews the clinical aspects of major ExRA, focusing on incidence, clinical features, and therapeutic approaches, and how modern immunosuppressive therapy can change the outcome.

  1. Multiphysical modelling of fluid transport through osteo-articular media

    Directory of Open Access Journals (Sweden)

    Thibault Lemaire

    2010-03-01

    Full Text Available In this study, a multiphysical description of fluid transport through osteo-articular porous media is presented. Adapted from the model of Moyne and Murad, which is intended to describe clayey materials behaviour, this multiscale modelling allows for the derivation of the macroscopic response of the tissue from microscopical information. First the model is described. At the pore scale, electrohydrodynamics equations governing the electrolyte movement are coupled with local electrostatics (Gauss-Poisson equation, and ionic transport equations. Using a change of variables and an asymptotic expansion method, the macroscopic description is carried out. Results of this model are used to show the importance of couplings effects on the mechanotransduction of compact bone remodelling.Neste estudo uma descrição multifísica do transporte de fluidos em meios porosos osteo articulares é apresentada. Adaptado a partir do modelo de Moyne e Murad proposto para descrever o comportamento de materiais argilosos a modelagem multiescala permite a derivação da resposta macroscópica do tecido a partir da informação microscópica. Na primeira parte o modelo é apresentado. Na escala do poro as equações da eletro-hidrodinâmica governantes do movimento dos eletrolitos são acopladas com a eletrostática local (equação de Gauss-Poisson e as equações de transporte iônico. Usando uma mudança de variáveis e o método de expansão assintótica a derivação macroscópica é conduzida. Resultados do modelo proposto são usados para salientar a importância dos efeitos de acoplamento sobre a transdução mecânica da remodelagem de ossos compactados.

  2. Asociación entre porphyromona gingivalis y proteína C reactiva en enfermedades sistémicas inflamatorias Association between porphyromonas gingivalis and C-reactive protein in systemic inflammatory diseases

    OpenAIRE

    C.M. Ardila Medina; G.I. Lafaurie Villamil

    2010-01-01

    La proteína C reactiva (PCR) es un marcador serológico de la inflamación asociado con incremento en el riesgo de enfermedades sistémicas inflamatorias (ESI). La periodontitis también se relaciona con niveles elevados de PCR en adultos y con una reducción de la misma después de su tratamiento. Así, se ha postulado que la PCR puede ser un posible mediador de la asociación entre periodontitis y ESI. Los patógenos periodontales además de inducir inflamación local y destrucción tisular están invol...

  3. The opinion of patients with inflammatory bowel disease on healthcare received Opinión de los pacientes con enfermedad inflamatoria intestinal sobre la atención sanitaria recibida

    Directory of Open Access Journals (Sweden)

    F. Casellas

    2004-03-01

    information, care of family members, and healthcare resources accessibility/agility.Fundamento: un elemento a tener en cuenta al analizar un modelo de atención sanitaria dirigido a un grupo de población afecta de una enfermedad crónica es el de los recursos sanitarios necesarios, su utilización y la valoración que tienen los usuarios de ellos. En la enfermedad inflamatoria intestinal (EII los recursos sanitarios utilizados por los enfermos son numerosos y variados, pero no han sido evaluados. Diseño: se ha realizado una encuesta autorrellenable anónima de 24 preguntas básicas a cerca de datos generales de la enfermedad, quién les controla, cómo se programan las visitas, necesidad de atención urgente, cómo creen que se puede mejorar su control, etc. La encuesta se remitió al domicilio de 393 pacientes para su contestación y se les pidió que la devolvieran por correo. Resultados: doscientos treinta y siete pacientes devolvieron la encuesta cumplimentada. La mayoría de los pacientes eran controlados en un hospital, y sólo el 8,8% lo eran por el médico de cabecera o especialista de zona. El 92% de pacientes refieren que las visitas se programan de forma rutinaria, independientemente del estado clínico. El 79,6% de pacientes refiere haber acudido alguna vez a urgencias, siendo el motivo en el 25,2% de las ocasiones no saber qué hacer o no tener otro recurso disponible. Ello explica que el 38% de visitas al servicio de urgencias se podrían haber evitado con un mejor conocimiento de la enfermedad o una consulta telefónica. El 30% de pacientes refiere que la actual atención sanitaria es inadecuada, ya sea por su contenido, la forma o el tiempo de espera. El 97,8% de pacientes cree que la información y conocimiento de la enfermedad ayudarían a su control, de forma que el 69,6% considera que con la información adecuada podrían iniciar el tratamiento ya antes de la visita médica. Otro aspecto poco atendido, y que el 74,6% de pacientes opina que ayudaría al

  4. The evolution of articular cartilage imaging and its impact on clinical practice

    International Nuclear Information System (INIS)

    Over the past four decades, articular cartilage imaging has developed rapidly. Imaging now plays a critical role not only in clinical practice and therapeutic decisions but also in the basic research probing our understanding of cartilage physiology and biomechanics. (orig.)

  5. Intra-articular ganglion arising from the meniscofemoral ligament of Humphrey

    International Nuclear Information System (INIS)

    We present a case of an intra-articular ganglion of the knee arising from the anterior meniscofemoral ligament of Humphrey. The MR imaging and arthroscopic appearance of the lesion are illustrated. (orig.)

  6. Effects of immobilization on thickness of superficial zone of articular cartilage of patella in rats

    Directory of Open Access Journals (Sweden)

    Khadija Iqbal

    2012-01-01

    Conclusion: Each segment of superficial zone behaves differentially on immobilization and remobilization. Perhaps a much longer duration of remobilization is required to reverse changes of immobilization in articular cartilage and plays a significant role in knee joint movements.

  7. Modulation of Apoptosis and Differentiation by the Treatment of Sulfasalazine in Rabbit Articular Chondrocytes

    OpenAIRE

    Lee, Won Kil; Kang, Jin Seok

    2016-01-01

    This study was conducted to examine the cellular regulatory mechanisms of sulfasalazine (SSZ) in rabbit articular chondrocytes treated with sodium nitroprusside (SNP). Cell phenotype was determined, and the MTT assay, Western blot analysis and immunofluorescence staining of type II collagen was performed in control, SNP-treated and SNP plus SSZ (50~200 μg/mL) rabbit articular chondrocytes. Cellular proliferation was decreased significantly in the SNP-treated group compared with that in the co...

  8. The Variations in Calcaneal Articular Facets In North Indian Population and its Clinical Implication

    OpenAIRE

    Deepinder Kaur Gandhi; Maninder Singh; Anupama Mahajan; Seema

    2012-01-01

    Aims and Objectives- To know the most common type of calcanei in North Indian population and itsclinical importance. There are three articular facets on superior surface of calcaneus- anterior, middle andposterior. Three types of calcanei are noted according to number and arrangement of the articular facets-type A, B and C. Methodology - The present studywas done on 300 dry adult human calcanei of unknownsex taken from Department of Anatomy Sri Guru Ram Das Institute of Medical Sciences and R...

  9. The use of dynamic culture devices in articular cartilage tissue engineering.

    OpenAIRE

    Akmal, M.

    2006-01-01

    Tissue engineered repair of articular cartilage has now become a clinical reality with techniques for cell culture having advanced from laboratory experimentation to clinical application. Despite the advances in the use of this technology in clinical applications, the basic cell culture techniques for autologous chondrocytes are still based on primitive in-vitro monolayer culture methods. Articular chondrocytes are known to undergo fibroblastic change in monolayer culture as this is not their...

  10. Development of a Valid and Reliable Knee Articular Cartilage Condition–Specific Study Methodological Quality Score

    OpenAIRE

    Joshua D Harris; Erickson, Brandon J.; Cvetanovich, Gregory L.; Abrams, Geoffrey D.; McCormick, Frank M.; Gupta, Anil K.; Nikhil N. Verma; Bach, Bernard R.; Cole, Brian J.

    2014-01-01

    Background: Condition-specific questionnaires are important components in evaluation of outcomes of surgical interventions. No condition-specific study methodological quality questionnaire exists for evaluation of outcomes of articular cartilage surgery in the knee. Purpose: To develop a reliable and valid knee articular cartilage–specific study methodological quality questionnaire. Study Design: Cross-sectional study. Methods: A stepwise, a priori–designed framework was created for developme...

  11. Intra-articular ganglion cysts of the knee: clinical and MR imaging features

    International Nuclear Information System (INIS)

    The purpose of this study was to present clinical and MR imaging features of intra-articular ganglion cysts of the knee. Retrospective review of 1685 consecutive medical records and MR examinations of the knee performed at three imaging centers allowed identification of 20 patients (13 men and 7 women; mean age 35 years), in whom evidence of intra-articular ganglion cyst was seen. Of the 20 ganglion cysts, 5 were found in the infrapatellar fat pad, 10 arose from the posterior cruciate ligament, and 5 from the anterior cruciate ligament. Three of five patients with ganglion cyst in the infrapatellar fat pad had a palpable mass. In 7 of 15 patients with ganglion cyst in the intercondylar notch, exacerbation of pain occurred in a squatting position. On four MR arthrographies, ganglion cysts were an intra-articular round, lobulated, low signal intensity lesion. Five cases of fat-suppressed contrast-enhanced T1-weighted SE images demonstrated peripheral thin rim enhancement. The clinical presentation of intra-articular ganglion cyst is varied according to its intra-articular location. The MR appearance of intra-articular ganglion cyst is characteristic and usually associated with the cruciate ligament or the infrapatellar fat pad. Magnetic resonance arthrography has no definite advantage over conventional MR in the evaluation of the lesion. For intra-articular ganglion cyst in the infrapatellar fat pad, fat-suppressed contrast-enhanced MR imaging could be useful, because a thin, rim-enhancing feature of intra-articular ganglion cyst allows it to be distinguished from synovial hemangioma and synovial sarcoma. (orig.)

  12. Intra-articular ganglion cysts of the knee: clinical and MR imaging features

    Energy Technology Data Exchange (ETDEWEB)

    Kim, M.G.; Cho, W.H. [Dept. of Radiology, Sanggye Paik Hospital, Inje University, Seoul (Korea); Kim, B.H.; Choi, J.A.; Lee, N.J.; Chung, K.B. [Dept. of Diagnostic Radiology, College of Medicine, Korea University, Seoul (Korea); Choi, Y.S.; Cho, S.B. [Dept. of Radiology, School of Medicine, Eulji University, Seoul (Korea); Lim, H.C. [Dept. of Orthopedic Surgery, College of Medicine, Korea University, Seoul (Korea)

    2001-05-01

    The purpose of this study was to present clinical and MR imaging features of intra-articular ganglion cysts of the knee. Retrospective review of 1685 consecutive medical records and MR examinations of the knee performed at three imaging centers allowed identification of 20 patients (13 men and 7 women; mean age 35 years), in whom evidence of intra-articular ganglion cyst was seen. Of the 20 ganglion cysts, 5 were found in the infrapatellar fat pad, 10 arose from the posterior cruciate ligament, and 5 from the anterior cruciate ligament. Three of five patients with ganglion cyst in the infrapatellar fat pad had a palpable mass. In 7 of 15 patients with ganglion cyst in the intercondylar notch, exacerbation of pain occurred in a squatting position. On four MR arthrographies, ganglion cysts were an intra-articular round, lobulated, low signal intensity lesion. Five cases of fat-suppressed contrast-enhanced T1-weighted SE images demonstrated peripheral thin rim enhancement. The clinical presentation of intra-articular ganglion cyst is varied according to its intra-articular location. The MR appearance of intra-articular ganglion cyst is characteristic and usually associated with the cruciate ligament or the infrapatellar fat pad. Magnetic resonance arthrography has no definite advantage over conventional MR in the evaluation of the lesion. For intra-articular ganglion cyst in the infrapatellar fat pad, fat-suppressed contrast-enhanced MR imaging could be useful, because a thin, rim-enhancing feature of intra-articular ganglion cyst allows it to be distinguished from synovial hemangioma and synovial sarcoma. (orig.)

  13. Diagnosis and management of an intra-articular foreign body in the foot.

    LENUS (Irish Health Repository)

    Mulhall, K J

    2002-10-01

    We describe a case of a small intra-articular foreign body in the foot presenting 48 hours following injury, which at operation showed early evidence of septic arthritis. It is essential to accurately localise periarticular foreign bodies in the foot and proceed to arthrotomy and debridement in all cases where there is radiological or clinical evidence to suggest intra-articular retention of a foreign body.

  14. Role of computerised tomography in management of intra-articular fractures of the os calcis

    OpenAIRE

    Kumar, V.; Hameed, A.; Bhattacharya, R.; McMurtry, I.

    2006-01-01

    This study aimed to look at the role played by the CT scan in decision making in the management of intra-articular fractures of the calcaneum. Twenty-four patients with intra-articular fractures of the calcaneum were included. Their initial radiographs and CT films were blinded and assessed by three independent observers. Based on this they were selected for operative or non-operative management. The actual management was also recorded. The data were then subjected to statistical analysis to ...

  15. The results of conservative treatment of intra-articular fractures in the calcaneum

    OpenAIRE

    Arslan, Huseyin; Subasi, Mehmet; Kesemenli, Cumhur; Necmioglu, Serdar

    2004-01-01

    Objectives: We evaluated the results of conservative treatment for displaced intra-articular fractures of the calcaneum and investigated the implications of radiologic and clinical signs on the outcome. Methods: Thirty-three patients (18 males, 15 females; mean age 38 years; range 18 to 61 years) with displaced intra-articular calcaneum fractures were treated with cast immobilization and non-weight bearing. According to the modified Essex-Lopresti classification, the fractures were type-a ...

  16. The classic: Chapter XVIII. Operative treatment in chronic articular ostitis. 1884.

    Science.gov (United States)

    Gibney, Virgil P

    2010-02-01

    This Classic article is a reprint of the original work by Virgil P. Gibney, Chapter XVIII. Operative Treatment in Chronic Articular Ostitis. An accompanying biographical sketch of Virgil P. Gibney, MD, is available at DOI 10.1007/s11999-009-1166-2 . The Classic Article is (c)1884 and is abridged from Gibney VP. Operative treatment in chronic articular ostitis. In: The Hip and Its Diseases. New York, NY, London, UK: Bermingham & Co; 1884:388-402. PMID:19936860

  17. Protein-based injectable hydrogels towards the regeneration of articular cartilage

    OpenAIRE

    Poveda Reyes, Sara

    2016-01-01

    [EN] Articular cartilage is a tissue with low capacity for self-restoration due to its avascularity and low cell population. It is located on the surface of the subchondral bone covering the diarthrodial joints. Degeneration of articular cartilage can appear in athletes, in people with genetic degenerative processes (osteoarthritis or rheumatoid arthritis) or due to a trauma; what produces pain, difficulties in mobility and progressive degeneration that finally leads to joint failure. Self-re...

  18. The Biological Effects of Sex Hormones on Rabbit Articular Chondrocytes from Different Genders

    OpenAIRE

    Shwu Jen Chang; Shyh Ming Kuo; Yen Ting Lin; Shan-Wei Yang

    2014-01-01

    The aim of this study was to investigate the biological effects of sex hormones (17 β -estradiol and testosterone) on rabbit articular chondrocytes from different genders. We cultured primary rabbit articular chondrocytes from both genders with varying concentration of sex hormones. We evaluate cell proliferation and biochemical functions by MTT and GAG assay. The chondrocyte function and phenotypes were analyzed by mRNA level using RT-PCR. Immunocytochemical staining was also used to evaluat...

  19. Manifestações articulares em pacientes com doença de Crohn e retocolite ulcerativa Articular manifestations in patients with Crohn's disease and ulcerative colitis

    OpenAIRE

    Cristina Costa Duarte Lanna; Maria de Lourdes Abreu Ferrari; Marco Antônio Parreiras de Carvalho; Aloísio Sales da Cunha

    2006-01-01

    Os sintomas articulares constituem a manifestação extra-intestinal mais comum em pacientes com doença de Crohn e com retocolite ulcerativa. Reconhecida como artrite colítica, e mais recentemente, artrite enteropática, está classificada como uma das doenças do grupo das espondiloartropatias. Reconhecidamente, há dois padrões de acometimento articular: 1) periférico, habitualmente, associado aos períodos de atividade da doença intestinal e sem associação com o antígeno HLA B27, e 2) axial, cara...

  20. T2 star relaxation times for assessment of articular cartilage at 3 T: a feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Mamisch, Tallal Charles [University Bern, Department of Orthopedic Surgery, Inselspital, Bern (Switzerland); University Bern, Magnetic Resonance Spectroscopy and Methodology, Department of Clinical Research, Bern (Switzerland); Hughes, Timothy [Siemens Medical Solutions, Erlangen (Germany); Mosher, Timothy J. [Penn State University College of Medicine, Musculoskeletal Imaging and MRI, Department of Radiology, Hershey, PA (United States); Mueller, Christoph [University of Erlangen, Department of Trauma Surgery, Erlangen (Germany); Trattnig, Siegfried [Medical University of Vienna, MR Center - High Field MR, Department of Radiology, Vienna (Austria); Boesch, Chris [University Bern, Magnetic Resonance Spectroscopy and Methodology, Department of Clinical Research, Bern (Switzerland); Welsch, Goetz Hannes [University of Erlangen, Department of Trauma Surgery, Erlangen (Germany); Medical University of Vienna, MR Center - High Field MR, Department of Radiology, Vienna (Austria)

    2012-03-15

    T2 mapping techniques use the relaxation constant as an indirect marker of cartilage structure, and the relaxation constant has also been shown to be a sensitive parameter for cartilage evaluation. As a possible additional robust biomarker, T2* relaxation time is a potential, clinically feasible parameter for the biochemical evaluation of articular cartilage. The knees of 15 healthy volunteers and 15 patients after microfracture therapy (MFX) were evaluated with a multi-echo spin-echo T2 mapping technique and a multi-echo gradient-echo T2* mapping sequence at 3.0 Tesla MRI. Inline maps, using a log-linear least squares fitting method, were assessed with respect to the zonal dependency of T2 and T2* relaxation for the deep and superficial regions of healthy articular cartilage and cartilage repair tissue. There was a statistically significant correlation between T2 and T2* values. Both parameters demonstrated similar spatial dependency, with longer values measured toward the articular surface for healthy articular cartilage. No spatial variation was observed for cartilage repair tissue after MFX. Within this feasibility study, both T2 and T2* relaxation parameters demonstrated a similar response in the assessment of articular cartilage and cartilage repair tissue. The potential advantages of T2*-mapping of cartilage include faster imaging times and the opportunity for 3D acquisitions, thereby providing greater spatial resolution and complete coverage of the articular surface. (orig.)

  1. T2 star relaxation times for assessment of articular cartilage at 3 T: a feasibility study

    International Nuclear Information System (INIS)

    T2 mapping techniques use the relaxation constant as an indirect marker of cartilage structure, and the relaxation constant has also been shown to be a sensitive parameter for cartilage evaluation. As a possible additional robust biomarker, T2* relaxation time is a potential, clinically feasible parameter for the biochemical evaluation of articular cartilage. The knees of 15 healthy volunteers and 15 patients after microfracture therapy (MFX) were evaluated with a multi-echo spin-echo T2 mapping technique and a multi-echo gradient-echo T2* mapping sequence at 3.0 Tesla MRI. Inline maps, using a log-linear least squares fitting method, were assessed with respect to the zonal dependency of T2 and T2* relaxation for the deep and superficial regions of healthy articular cartilage and cartilage repair tissue. There was a statistically significant correlation between T2 and T2* values. Both parameters demonstrated similar spatial dependency, with longer values measured toward the articular surface for healthy articular cartilage. No spatial variation was observed for cartilage repair tissue after MFX. Within this feasibility study, both T2 and T2* relaxation parameters demonstrated a similar response in the assessment of articular cartilage and cartilage repair tissue. The potential advantages of T2*-mapping of cartilage include faster imaging times and the opportunity for 3D acquisitions, thereby providing greater spatial resolution and complete coverage of the articular surface. (orig.)

  2. Un tren andino para la hidrovía del Magdalena

    OpenAIRE

    Duque Escobar, Gonzalo

    2015-01-01

    Para implementar la multimodalidad e integrar el sistema de transporte de carga de la Región Andina de Colombia, una solución viable es el Ferrocarril Cafetero, que contempla un túnel de 17 km perforando las rocas estables del norte de Cerro Bravo, a 2200 msnm entre Brasil y Mangabonita. Dicho tren entre La Dorada y el Km 41, articularía la Hidrovía del Magdalena con el Corredor Férreo del río Cauca, y a futuro permitiría el establecimiento del Corredor Bimodal Cafetero, facilitando la constr...

  3. Anticuerpo anticitrulina y manifestaciones extra articulares en artritis reumatoidea

    Directory of Open Access Journals (Sweden)

    María Jezabel Haye Salinas

    2013-02-01

    Full Text Available Los pacientes con artritis reumatidea (AR pueden desarrollar manifestaciones extra articulares (MExA, relacionadas a su morbi-mortalidad. Los anticuerpos anti-péptidos citrulinados cíclicos (ACCP son específicos para la AR y estan relacionados con el daño articular; y podrían tener rol patogénico en las MExA. Nuestro objetivo fue determinar la relación entre los anticuerpos ACCP y MExA en pacientes con AR. Se incluyeron 74 pacientes con diagnóstico de AR (ACR 1987 mayores de 18 años, de más de 6 meses de evolución, con MExA, y un control apareado por sexo y edad sin MExA por cada paciente. Las variables demográficas, clínicas y de laboratorio se compararon con test t, chi cuadrado o Mann-Whitney. Se realizó análisis multivariado; p ≤ 0.05. Los pacientes con MExA presentaron mayor título de anticuerpo ACCP (116 vs. 34, p < 0.01 y de factor reumatoideo (FR (108 vs. 34.5, p < 0.01. En el análisis multivariado hubo asociación entre la presencia de MExA y tabaquismo activo (p = 0.02, OR: 3.78, IC 95%: 1.17-12.2, FR positivo (p = 0.04, OR: 3.23, IC95%: 1.04-11.8 y anticuerpo ACCP positivo (p = 0.04, OR: 3.23, IC 95%: 1.04-10. Presentaron mayor título de anticuerpo ACCP que los controles los pacientes con xerostomía (109 vs. 34, p = 0.04, xeroftalmia (150 vs. 34, p < 0.01, nódulos sub-cutáneos (NSC (141 vs. 34, p < 0.01 y fibrosis pulmonar (158 vs. 34, p = 0.04. En conclusión, el anticuerpo ACCP positivo, el FR positivo y el tabaquismo activo fueron factores de riesgo independientes para el desarrollo de MExA.

  4. Infección Activa por el Citomegalovirus (CMV) en el trasplante alogénico de precursores hematopoyéticos:Investigación de nuevos factores biológicos para la estimación del riesgo y análisis integral de los mecanismos inmunitarios que la previenen y controlan

    OpenAIRE

    Giménez Quiles, Estela Berenice

    2016-01-01

    Citomegalovirus (CMV) es causa frecuente de morbididad y mortalidad en el marco del trasplante alogénico de precursores hematopoyéticos (alo-TPH). CMV puede ocasionar enfermedad orgánica o tisular (neumonía intersticial o enfermedad gastrointestinal, con mayor frecuencia), en virtud de su “citopatogenicidad” . CMV también puede causar morbididad a través de mecanismos indirectos, relacionados con su capacidad inmunosupresora y pro-inflamatoria; en ese contexto, CMV parece incrementar el ries...

  5. Análisis de polimorfismos de genes implicados en la regulación del endotelio y la inflamación en pacientes con insuficiencia cardíaca y su relación con el tipo de disfunción ventricular predominante

    OpenAIRE

    Ruiz Olgado, Maria Jose

    2010-01-01

    [ES] La insuficiencia cardiaca está determinada por factores genéticos y ambientales. El sistema endotelial y la respuesta inflamatoria son esenciales en el remodelado vascular en la insuficiencia cardiaca. Polimorfismos de genes que codifican la endotelina-1 (ET-1), la sintasa endotelial del óxido nítrico (NOS), la interleucina-6 (IL-6) y la ciclooxigenasa-2 (COX2) podrían estar relacionados con el remodelado ventricular en pacientes con insuficiencia cardiaca. Nuestro objetivo fue invest...

  6. ACTIVITY OF CANONICAL WNT SIGNAL SYSTEM IN HYALINE CARTILAGE ARTICULAR CHONDROCYTES IN PROCESS OF SYNOVIAL JOINT DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    A.O. Molotkov

    2009-03-01

    Full Text Available Canonical and non-canonical Wnt systems are essential regulators of chondrogenesis and bone development. However, the roles of these systems in synovial joint development are not well studied. To determine if canonical Wnt system is active in developing articular chondrocytes we used immunohistochemistry for в-galactosidase and doublecortin (cell-type specific marker for articular chondrocytes to double label sections through joint regions of E14.5, E18.5, P10 and adult mice. Here the following results are presented. Canonical Wnt signal system does not work in developing articular chondrocytes at early embryonic stages (E14.5; it is active in the articular chondrocytes at late embryonic stages (E16.5-E18.5 and during postnatal development (P7-P10, but is turned off again in the adult articular chondrocytes. These results suggest that canonical Wnt signaling is being regulated during articular chondrocytes differentiation and joint formation.

  7. Anticuerpo anticitrulina y manifestaciones extra articulares en artritis reumatoidea Anticitrulin antibody and the extra-articular manifestations in rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    María Jezabel Haye Salinas

    2013-02-01

    Full Text Available Los pacientes con artritis reumatidea (AR pueden desarrollar manifestaciones extra articulares (MExA, relacionadas a su morbi-mortalidad. Los anticuerpos anti-péptidos citrulinados cíclicos (ACCP son específicos para la AR y estan relacionados con el daño articular; y podrían tener rol patogénico en las MExA. Nuestro objetivo fue determinar la relación entre los anticuerpos ACCP y MExA en pacientes con AR. Se incluyeron 74 pacientes con diagnóstico de AR (ACR 1987 mayores de 18 años, de más de 6 meses de evolución, con MExA, y un control apareado por sexo y edad sin MExA por cada paciente. Las variables demográficas, clínicas y de laboratorio se compararon con test t, chi cuadrado o Mann-Whitney. Se realizó análisis multivariado; p ≤ 0.05. Los pacientes con MExA presentaron mayor título de anticuerpo ACCP (116 vs. 34, p A large proportion of rheumatoid arthritis (RA patients develop extra-articular manifestations (EAM, which are associated with morbidity and early mortality. Anti cyclic citrullinated peptide (ACCP antibody has proven to be highly specific for the diagnosis of RA, associated with severe joint damage and may have some role in the pathogenesis of EAM. The aim of this study was to determine the relationship between ACCP antibody and the presence of EAM in RA patients. Seventy four RA patients (ACR 1987 with EAM, > 18 years, more than 6 months duration were included, and an EAM free control, matched by sex and age, for each patient. Demographic, clinical and laboratory variables were compared using t-test, chi-square or Mann-Whitney test. Multivariate analysis was performed: p ≤ 0.05. Patients with EAM presented a greater value of ACCP antibody (116 vs. 34, p < 0.01 and rheumatoid factor (108 vs. 34.5, p < 0.01. Independent association with current smoking habit (p = 0.02, OR = 3.78, 95%: 1.17-12.2, RF positive (p = 0.04, OR 3.23, CI 95%: 1.04 to 11.8 and ACCP antibody positive (p = 0.04, OR 3.23, 95% CI: 1

  8. Early Intra-Articular Complement Activation in Ankle Fractures

    Directory of Open Access Journals (Sweden)

    Hagen Schmal

    2014-01-01

    Full Text Available Cytokine regulation possibly influences long term outcome following ankle fractures, but little is known about synovial fracture biochemistry. Eight patients with an ankle dislocation fracture were included in a prospective case series and matched with patients suffering from grade 2 osteochondritis dissecans (OCD of the ankle. All fractures needed external fixation during which joint effusions were collected. Fluid analysis was done by ELISA measuring aggrecan, bFGF, IL-1β, IGF-1, and the complement components C3a, C5a, and C5b-9. The time periods between occurrence of fracture and collection of effusion were only significantly associated with synovial aggrecan and C5b-9 levels (P<0.001. Furthermore, synovial expressions of both proteins correlated with each other (P<0.001. Although IL-1β expression was relatively low, intra-articular levels correlated with C5a (P<0.01 and serological C-reactive protein concentrations 2 days after surgery (P<0.05. Joint effusions were initially dominated by neutrophils, but the portion of monocytes constantly increased reaching 50% at day 6 after fracture (P<0.02. Whereas aggrecan and IL-1β concentrations were not different in fracture and OCD patients, bFGF, IGF-1, and all complement components were significantly higher concentrated in ankle joints with fractures (P<0.01. Complement activation and inflammatory cell infiltration characterize the joint biology following acute ankle fractures.

  9. Rice Body Formation Within a Peri-Articular Shoulder Mass.

    Science.gov (United States)

    Edison, Michele N; Caram, Anthony; Flores, Miguel; Scherer, Kurt

    2016-01-01

    Most commonly associated with chronic inflammatory conditions, rice bodies represent an uncommon, nonspecific, often intra-articular inflammatory process. Presumably, rice bodies represent the sequelae of microvascular infarcts of the joint synovium. However, rice bodies have been seen in pleural fluid, in the setting of bursitis, and within the tendon sheath. The etiology and prognostic significance of rice bodies are not clear. MRI is the diagnostic imaging modality of choice for the evaluation of rice body formation. Here we present a case of a 28-year-old female with a history of rheumatoid arthritis (RA) who presented to her primary care physician with a palpable mass around her right shoulder which was presumed to be a lipoma. An initial ultrasound showed a fluid filled structure with internal debris. Subsequent MRI evaluation was confirmatory for subacromial-subdeltoid bursitis with rice body formation. The salient point of this report is to highlight the importance of patient-specific differential diagnosis. While lipomas are a very common benign soft tissue tumor, patients with RA often have disease-specific sequelae that should be included in the diagnostic deliberation. Thus, when ordering diagnostic testing for patients with a palpable mass and rheumatoid arthritis, MRI--possibly preceded by conventional radiography--is the most appropriate diagnostic algorithm. PMID:27625904

  10. Regeneration of articular cartilage using adipose stem cells.

    Science.gov (United States)

    Im, Gun-Il

    2016-07-01

    Articular cartilage (AC) has limited potential for self-regeneration and damage to AC eventually leads to the development and progression of osteoarthritis (OA). Cell implantation strategies have emerged as a new treatment modality to regenerate AC. Adipose stem cells/adipose-derived stromal cells (ASCs) have gained attention due to their abundance, excellent proliferative potential, and minimal morbidity during harvest. These advantages lower the cost of cell therapy by circumventing time-consuming procedure of culture expansion. ASCs have drawn attention as a potential source for cartilage regeneration since the feasibility of chondrogenesis from ASCs was first reported. After several groups reported inferior chondrogenesis from ASCs, numerous methods were devised to overcome the intrinsic properties. Most in vivo animal studies have reported good results using predifferentiated or undifferentiated, autologous or allogeneic ASCs to regenerate cartilage in osteochondral defects or surgically-induced OA. In this review, we summarize literature on the isolation and in vitro differentiation processes of ASCs, in vivo studies to regenerate AC in osteochondral defects and OA using ASCs, and clinical applications of ASCs. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1830-1844, 2016. PMID:26990234

  11. Assessment of Intraoperative Intra-articular Morphine and Clonidine Injection in the Acute Postoperative Period After Hip Arthroscopy

    OpenAIRE

    Cogan, Charles J.; Knesek, Michael; Tjong, Vehniah K.; Nair, Rueben; Kahlenberg, Cynthia; Dunne, Kevin F.; Mark C. Kendall; Terry, Michael A.

    2016-01-01

    Background: Previous authors have suggested that intra-articular morphine and clonidine injections after knee arthroscopy have demonstrated equivocal analgesic effect in comparison with bupivacaine while circumventing the issue of chondrotoxicity. There have been no studies evaluating the effect of intra-articular morphine after hip arthroscopy. Purpose: To evaluate the efficacy of intra-articular morphine in combination with clonidine on postoperative pain and narcotic consumption after hip ...

  12. Efecto de las cargas articulares sobre el flujo y pH salival Effect of TMJ loading on salivary flow and pH

    Directory of Open Access Journals (Sweden)

    RJ Castro

    2011-04-01

    Full Text Available Una alteración del flujo salival es clave en el desarrollo de caries, enfermedad periodontal e infecciones oportunistas. El flujo salival está determinado por diversos estímulos que actúan sobre receptores de distinta naturaleza, entre ellos mecanoreceptores articulares. Algunos estudios demuestran que las cargas articulares actúan sobre estos receptores, modificando cualitativa y cuantitativamente la secreción salival. El objetivo de este estudio fue determinar si existe una relación entre la aplicación controlada de cargas articulares y cambios en el flujo y pH salival. 30 voluntarios fueron seleccionados según criterios de inclusión establecidos. Se elaboró un dispositivo interoclusal que en relación a piezas 1.5 y 2.5, tenía botones acrílicos de 1 mm de espesor, los que al ejercer fuerzas sobre ellos provocan cargas reversibles sobre la ATM. Antes de usar el dispositivo, en cada individuo se midió flujo salival no estimulado (FSNE el flujo salival estimulado (FSE y el pH de ambos. Tras un periodo de adaptación diaria por una semana, cada participante usó el dispositivo durante 1 hora, ejerciendo fuerza masticatoria sostenida. Luego se midieron ambos flujos y el pH correspondiente. El procedimiento fue repetido por 7 días, bajo supervisión. No se observó una relación aparente entre la aplicación controlada de cargas articulares y cambios volumétricos de flujo salival. Las mujeres tuvieron un FSE y FSNE menor al de los hombres. La aplicación de sobrecargas articulares por un breve período de tiempo provoca una caída del pH del FSE luego de 3 días de aplicación.Altered salivary flow is key for the onset of dental caries, periodontal disease and opportunistic infections. Salivary flow is determined by various stimuli on several receptors, including joint mechanoreceptors. Some studies show that loads on the TMJ affect these receptors causing changes on the quality and quantity of saliva secretion. The aim of this

  13. Usefulness of fluoroscopy-guided intra-articular injection of the knee

    Energy Technology Data Exchange (ETDEWEB)

    Myung, Jae Sung; Lee, Joon Woo [Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Lee, Ji Yeon [Kangwon National University College of Medicine, Chuncheon (Korea, Republic of)] (and others)

    2007-06-15

    To determine the accuracy of the intra-articular location of hyaluronic acid injection using a blind approach and to establish the usefulness of fluoroscopy-guided intra-articular injection. A fluoroscopy unit was used for 368 intra-articular injections of hyaluronic acid to 93 knees in 65 patients. Initially, blind needle positioning was conducted on the fluoroscopy table. The failure rate of the blind approach among the 368 injections was evaluated, and a relationship between the Kellgren-Lawrence grade (K-L grade) and the incidence of repeated failures using the blind approach was determined for injections to 52 knees in 37 patients who received a complete cycle of injections (five consecutive injections with a one-week interval between injections). Using a blind approach, 298 of 368 trials (81.2%) resulted in a needle tip being placed in an intra-articular location, while 70 of 368 trials resulted in an extra-articular placement of the needle tip. Among 52 knees to which a complete cycle of injection (five consecutive injections with a one-week interval between injections) was administered, repeated failure of intra-articular placement using the blind approach was seen for 18 knees (34.6%); a more severe K-L grade assigned was associated with a higher rate of repeated failure. However, the trend was not statistically significant based on the Chi-squared test ({rho} value = 0.14). Fluoroscopy-guided needle placement may be helpful to ensure therapeutic intra-articular injection of the knee.

  14. OPERATIVE MANAGEMENT OF INTRA-ARTICULAR DISTAL HUMERAL FRACTURES WITH LOCKING PLATES

    Directory of Open Access Journals (Sweden)

    Abhilekh

    2015-11-01

    Full Text Available BACKGROUND: Intra-articular distal humeral fractures are common, but complex elbow injuries. To obtain good results, anatomical reduction with rigid fixation and early range of mobilization is required. Treatment of these fractures with conventional plates is associated with many complications such as non-anatomic reduction of articular surfaces, malunion, non-union, loosening of implant, residual stiffness of the elbow and post-traumatic osteoarthrosis. In this situation the application of locking plates having a fixed angle plate screw construct can minimise most of the above complications. OBJECTIVE: To evaluate radiological and functional outcome of locking plate application for the management of intra-articular distal humeral fractures. MATERIAL AND METHODS: This prospective study was conducted from January 2013 to December 2014. We operated 20 patients of AO type-C intra-articular distal humeral fractures. Fracture was exposed using modified Campbell’s posterior approach in less comminuted fractures and a V-shaped Olecranon osteotomy was done to get better exposure of the articular surface in cases with severe articular comminution. The fracture was stabilized using an intercondylar screw, pre-contoured locking compression plates and/or locking reconstruction plates as per preoperative planning. Patients were reviewed at monthly interval for clinical-radiological evaluation. Final outcome measures included radiological assessment, range of motion and Mayo elbow performance score (MEPS. RESULTS: All the fractures were united at an average 12 weeks. Two patients developed numbness in the distribution of ulnar nerve and one patient developed superficial infection in immediate postoperative period. None of the patients had malunion and loosening of implant. The average arc of flexion-extension was 105`, although no patient had loss of supination/pronation. Mayo Elbow Performance Score was excellent in 15 (75%, good in 3 (15%, fair in 1 (5

  15. Identification of latexin by a proteomic analysis in rat normal articular cartilage

    Directory of Open Access Journals (Sweden)

    Kouri Juan B

    2010-06-01

    Full Text Available Abstract Background Osteoarthritis (OA is characterized by degeneration of articular cartilage. Animal models of OA induced are a widely used tool in the study of the pathogenesis of disease. Several proteomic techniques for selective extraction of proteins have provided protein profiles of chondrocytes and secretory patterns in normal and osteoarthritic cartilage, including the discovery of new and promising biomarkers. In this proteomic analysis to study several proteins from rat normal articular cartilage, two-dimensional electrophoresis and mass spectrometry (MS were used. Interestingly, latexin (LXN was found. Using an immunohistochemical technique, it was possible to determine its localization within the chondrocytes from normal and osteoarthritic articular cartilage. Results In this study, 147 proteins were visualized, and 47 proteins were identified by MS. A significant proportion of proteins are involved in metabolic processes and energy (32%, as well as participating in different biological functions including structural organization (19%, signal transduction and molecular signaling (11%, redox homeostasis (9%, transcription and protein synthesis (6%, and transport (6%. The identified proteins were assigned to one or more subcellular compartments. Among the identified proteins, we found some proteins already recognized in other studies such as OA-associated proteins. Interestingly, we identified LXN, an inhibitor of mammalian carboxypeptidases, which had not been described in articular cartilage. Immunolabeling assays for LXN showed a granular distribution pattern in the cytoplasm of most chondrocytes of the middle, deep and calcified zones of normal articular cartilage as well as in subchondral bone. In osteoarthritic cartilage, LXN was observed in superficial and deep zones. Conclusions This study provides the first proteomic analysis of normal articular cartilage of rat. We identified LXN, whose location was demonstrated by

  16. LA REGULACIÓN DEL TURISMO. UN ASOMO SOCIO-JURÍDICO DE LOS SUJETOS INTEGRANTES DEL SECTOR (PRIMERA PARTE)

    OpenAIRE

    GOMEZ, DANIEL RIGOBERTO BERNAL

    2014-01-01

    El Turismo en Colombia constituye una de las funciones más importantes para el desarrollo de nuestra Nación, a veces con el asocio de los ministerios de Cultura y Hacienda se implementan políticas para promover la economía del país y la generación de empleo para la sociedad colombiana.También para articular procesos de identificación, valoración, competitividad, sostenibilidad y difusión del patrimonio cultural colombiano.

  17. MR diffusion weighted imaging experimental study on early stages of articular cartilage degeneration of knee

    International Nuclear Information System (INIS)

    Objective: To study the appearance of MR diffusion weighted imaging in early stages of cartilage degeneration and to detect its values. Methods: In 20 goat left knees, intra- articular injection of 5 units of papain was performed causing a loss of cartilage proteoglycan. Twenty right knees were used as control group. MR diffusion weighted imaging was performed at 24 hours after intra-articular injection of papain. ADC of each part of articular cartilage was measured and compared with each other. The proteoglycan content was measured biochemically and histochemically. Routine MRI and DWI were performed in 100 patients with osteoarthritis and 20 healthy people. The ADC of each interested part of articular cartilage was measured and compared with each other. Results: In experimental control group, the ADCav of articular cartilage was (14.2±2.3) x 10-4 mm2/s. In early stages of cartilage degeneration group, the ADCav of articular cartilage was (17.5±4.2) x 10-4 mm2/s. The ADCav of the control group was lower than that of the early stages of cartilage degeneration group (t=2.709; P=0.016). The proteloglycan content of articular cartilage was 4.22 x 106 μg/kg in control group, and 0.82 x 106 μg/kg in experimental group at 24 hours after injection of papain. The difference between control group and experimental group was significant (t=2.705, P=0.018). In healthy people, the ADCav of articular cartilage was (7.6±2.2) x 10-4 mm2/s. In osteoarthritis group, the ADCav of articular cartilage was (10.3±4.2) x 10-4 mm2/s. The ADCav in the healthy group was significantly lower than that in the osteoarthritis group (t=2.609,P=0.014). Conclusion: DWI is an useful method in detecting early stages of cartilage degeneration which can not be showed on routine sequences. (authors)

  18. Serum-free media for articular chondrocytes in vitro expansion

    Institute of Scientific and Technical Information of China (English)

    SHAO Xin-xin; Neil A.Duncan; LIN Lin; FU Xin; ZHANG Ji-ying; YU Chang-long

    2013-01-01

    Background In vitro chondrocyte expansion is a major challenge in cell-based therapy for human articular cartilage repair.Classical culture conditions usually use animal serum as a medium supplement,which raises a number of undesirable questions.In the present study,two kinds of defined,serum-free media were developed to expand chondrocytes in monolayer culture for the purpose of cartilage tissue engineering.Methods Bovine chondrocytes were expanded in serum-free media supplemented with fibroblast growth factor-2 and platelet-derived growth factor or fibroblast growth factor-2 and insulin-like growth factor.Expansion culture in a conventional 10% fetal bovine serum (FBS) medium served as control.Fibronectin coating was used to help cell adhesion in serum-free medium.Next,in vitro three-dimensional pellet culture was used to evaluate the chondrocyte capacity.Cell pellets were expanded in different media to re-express the differentiated phenotype (re-differentiation) and to form cartilaginous tissue.The pellets were assessed by glycosaminoglycans contents,collagen II,collagen I and collagen X immunohistological staining.Results Chondrocytes cultured in serum-free media showed no proliferation difference than cells grown with 10% FBS medium.In addition,chondrocytes expanded in both serum-free media expressed more differentiated phenotypes at the end of monolayer culture,as indicated by higher gene expression ratios of collagen type Ⅱ to collagen type Ⅰ.Pellets derived from chondrocytes cultured in both serum-free media displayed comparable chondrogenic capacities to pellets from cells expanded in 10% FBS medium.Conclusion These findings provide alternative culture approaches for chondrocytes in vitro expansion,which may benefit the clinical use of autologous chondrocytes implantation.

  19. Multi-parametric MRI characterization of enzymatically degraded articular cartilage.

    Science.gov (United States)

    Nissi, Mikko J; Salo, Elli-Noora; Tiitu, Virpi; Liimatainen, Timo; Michaeli, Shalom; Mangia, Silvia; Ellermann, Jutta; Nieminen, Miika T

    2016-07-01

    Several laboratory and rotating frame quantitative MRI parameters were evaluated and compared for detection of changes in articular cartilage following selective enzymatic digestion. Bovine osteochondral specimens were subjected to 44 h incubation in control medium or in collagenase or chondroitinase ABC to induce superficial collagen or proteoglycan (glycosaminoglycan) alterations. The samples were scanned at 9.4 T for T1 , T1 Gd (dGEMRIC), T2 , adiabatic T1 ρ , adiabatic T2 ρ , continuous-wave T1 ρ , TRAFF2 , and T1 sat relaxation times and for magnetization transfer ratio (MTR). For reference, glycosaminoglycan content, collagen fibril orientation and biomechanical properties were determined. Changes primarily in the superficial cartilage were noted after enzymatic degradation. Most of the studied parameters were sensitive to the destruction of collagen network, whereas glycosaminoglycan depletion was detected only by native T1 and T1 Gd relaxation time constants throughout the tissue and by MTR superficially. T1 , adiabatic T1 ρ , adiabatic T2 ρ , continuous-wave T1 ρ , and T1 sat correlated significantly with the biomechanical properties while T1 Gd correlated with glycosaminoglycan staining. The findings indicated that most of the studied MRI parameters were sensitive to both glycosaminoglycan content and collagen network integrity, with changes due to enzymatic treatment detected primarily in the superficial tissue. Strong correlation of T1 , adiabatic T1ρ , adiabatic T2 ρ , continuous-wave T1 ρ , and T1 sat with the altered biomechanical properties, reflects that these parameters were sensitive to critical functional properties of cartilage. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1111-1120, 2016. PMID:26662555

  20. Modeling IL-1 induced degradation of articular cartilage.

    Science.gov (United States)

    Kar, Saptarshi; Smith, David W; Gardiner, Bruce S; Li, Yang; Wang, Yang; Grodzinsky, Alan J

    2016-03-15

    In this study, we develop a computational model to simulate the in vitro biochemical degradation of articular cartilage explants sourced from the femoropatellar grooves of bovine calves. Cartilage explants were incubated in culture medium with and without the inflammatory cytokine IL-1α. The spatio-temporal evolution of the cartilage explant's extracellular matrix components is modelled. Key variables in the model include chondrocytes, aggrecan, collagen, aggrecanase, collagenase and IL-1α. The model is first calibrated for aggrecan homeostasis of cartilage in vivo, then for data on (explant) controls, and finally for data on the IL-1α driven proteolysis of aggrecan and collagen over a 4-week period. The model was found to fit the experimental data best when: (i) chondrocytes continue to synthesize aggrecan during the cytokine challenge, (ii) a one to two day delay is introduced between the addition of IL-1α to the culture medium and subsequent aggrecanolysis, (iii) collagen degradation does not commence until the total concentration of aggrecan (i.e. both intact and degraded aggrecan) at any specific location within the explant becomes ≤1.5 mg/ml and (iv) degraded aggrecan formed due to the IL-1α induced proteolysis of intact aggrecan protects the collagen network while collagen degrades in a two-step process which, together, significantly modulate the collagen network degradation. Under simulated in vivo conditions, the model predicts increased aggrecan turnover rates in the presence of synovial IL-1α, consistent with experimental observations. Such models may help to infer the course of events in vivo following traumatic joint injury, and may also prove useful in quantitatively evaluating the efficiency of various therapeutic molecules that could be employed to avoid or modify the course of cartilage disease states. PMID:26874194

  1. Nanosized fibers' effect on adult human articular chondrocytes behavior

    International Nuclear Information System (INIS)

    Tissue engineering with chondrogenic cell based therapies is an expanding field with the intention of treating cartilage defects. It has been suggested that scaffolds used in cartilage tissue engineering influence cellular behavior and thus the long-term clinical outcome. The objective of this study was to assess whether chondrocyte attachment, proliferation and post-expansion re-differentiation could be influenced by the size of the fibers presented to the cells in a scaffold. Polylactic acid (PLA) scaffolds with different fiber morphologies were produced, i.e. microfiber (MS) scaffolds as well as nanofiber-coated microfiber scaffold (NMS). Adult human articular chondrocytes were cultured in the scaffolds in vitro up to 28 days, and the resulting constructs were assessed histologically, immunohistochemically, and biochemically. Attachment of cells and serum proteins to the scaffolds was affected by the architecture. The results point toward nano-patterning onto the microfibers influencing proliferation of the chondrocytes, and the overall 3D environment having a greater influence on the re-differentiation. In the efforts of finding the optimal scaffold for cartilage tissue engineering, studies as the current contribute to the knowledge of how to affect and control chondrocytes behavior. - Highlights: ► Chondrocyte behavior in nanofiber-coated microfiber versus microfiber scaffolds ► High porosity (> 90%) and large pore sizes (a few hundred μm) of nanofibrous scaffolds ► Proliferation enhanced by presence of nanofibers ► Differentiation not significantly affected ► Cell attachment improved in presence of both nanofibers and serum

  2. Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.

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    Kotaro Azuma

    Full Text Available Steroid and xenobiotic receptor (SXR and its murine ortholog, pregnane X receptor (PXR, are nuclear receptors that are expressed at high levels in the liver and the intestine where they function as xenobiotic sensors that induce expression of genes involved in detoxification and drug excretion. Recent evidence showed that SXR and PXR are also expressed in bone tissue where they mediate bone metabolism. Here we report that systemic deletion of PXR results in aging-dependent wearing of articular cartilage of knee joints. Histomorphometrical analysis showed remarkable reduction of width and an enlarged gap between femoral and tibial articular cartilage in PXR knockout mice. We hypothesized that genes induced by SXR in chondrocytes have a protective effect on articular cartilage and identified Fam20a (family with sequence similarity 20a as an SXR-dependent gene induced by the known SXR ligands, rifampicin and vitamin K2. Lastly, we demonstrated the biological significance of Fam20a expression in chondrocytes by evaluating osteoarthritis-related gene expression of primary articular chondrocytes. Consistent with epidemiological findings, our results indicate that SXR/PXR protects against aging-dependent wearing of articular cartilage and that ligands for SXR/PXR have potential role in preventing osteoarthritis caused by aging.

  3. Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage.

    Science.gov (United States)

    Azuma, Kotaro; Casey, Stephanie C; Urano, Tomohiko; Horie-Inoue, Kuniko; Ouchi, Yasuyoshi; Blumberg, Bruce; Inoue, Satoshi

    2015-01-01

    Steroid and xenobiotic receptor (SXR) and its murine ortholog, pregnane X receptor (PXR), are nuclear receptors that are expressed at high levels in the liver and the intestine where they function as xenobiotic sensors that induce expression of genes involved in detoxification and drug excretion. Recent evidence showed that SXR and PXR are also expressed in bone tissue where they mediate bone metabolism. Here we report that systemic deletion of PXR results in aging-dependent wearing of articular cartilage of knee joints. Histomorphometrical analysis showed remarkable reduction of width and an enlarged gap between femoral and tibial articular cartilage in PXR knockout mice. We hypothesized that genes induced by SXR in chondrocytes have a protective effect on articular cartilage and identified Fam20a (family with sequence similarity 20a) as an SXR-dependent gene induced by the known SXR ligands, rifampicin and vitamin K2. Lastly, we demonstrated the biological significance of Fam20a expression in chondrocytes by evaluating osteoarthritis-related gene expression of primary articular chondrocytes. Consistent with epidemiological findings, our results indicate that SXR/PXR protects against aging-dependent wearing of articular cartilage and that ligands for SXR/PXR have potential role in preventing osteoarthritis caused by aging. PMID:25749104

  4. Evaluation on Cartilage Morphology after Intra-Articular Injection of Titanium Dioxide Nanoparticles in Rats

    International Nuclear Information System (INIS)

    Nano scale wear particles would generate from orthopedic implants with nano scale surface topography because of residual stress. In this study, the effect of TiO2 nanoparticles on articular cartilage was investigated by intra-articular injection in rats. Using contrast-enhanced high-resolution micro computed tomography (micro-CT) technology, the decreased thickness of articular cartilage in distal femur was determined at 1, 7, 14, and 30 days after nanoparticle exposure. A strong linear correlation (r=0.928, P2 nanoparticles, cartilage thickness showed time-dependent decrease, and cartilage volume was decreased too. Further, the histopathological examination showed the edema chondrocyte and shrinked nucleus in the radial and calcified zone of cartilage. The ultrastructure of articular cartilage implied that the chondrocytes was degenerated, expressing as the condensed chromatin, the dilated endoplasmic reticulum, and the rich mitochondria. Even, the fragments of ruptured endoplasmic reticulum were observed in the cytoplasm of chondrocytes at postexposure day 30. Results indicate that potential damage of articular cartilage was induced by particles existed in knee joint and imply that the bio monitoring should be strengthened in patients with prostheses replacement.

  5. X-ray dark field imaging of human articular cartilage: Possible clinical application to orthopedic surgery

    International Nuclear Information System (INIS)

    Despite its convenience and non-invasiveness on daily clinical use, standard X-ray radiography cannot show articular cartilage. We developed a novel type of X-ray dark field imaging (DFI), which forms images only by a refracted beam with very low background illumination. We examined a disarticulated distal femur and a shoulder joint with surrounding soft tissue and skin, both excised from a human cadaver at the BL20B2 synchrotron beamline at SPring-8. The field was 90 mm wide and 90 mm high. Articular cartilage of the disarticulated distal femur was obvious on DFI, but not on standard X-ray images. Furthermore, DFI allowed visualization in situ of articular cartilage of the shoulder while covered with soft tissue and skin. The gross appearance of the articular cartilage on the dissected section of the proximal humerus was identical to the cartilage shown on the DFI image. These results suggested that DFI could provide a clinically accurate method of assessing articular cartilage. Hence, DFI would be a useful imaging tool for diagnosing joint disease such as osteoarthritis

  6. [Basophilic line of the articular cartilage in normal and various pathological states].

    Science.gov (United States)

    Gongadze, L R

    1987-04-01

    Epiphyses of long tubular bones in the man and animals of various age, as well as experimental material of the adjuvant arthritis, with special reference to the basal part of the articular cartilage have been studied by means of histological, histochemical and histometrical methods. The structural-chemical organization of the basophilic line (tidemark) of the articular cartilage ensures its barrier role and participation in regulating selective permeability. Reconstruction of the tidemark in the process of physiological ageing and in cases of the articular pathology is aimed to preserve its integrity and in this way a complete differentiation of the noncalcified and calcified structures is secured. Disturbance of the basophilic line results in changes of the articular selective permeability, in invasion of vessels and structural elements of the bone marrow, and in development of profound distrophic and destructive changes of the cartilage--in deforming artrosis. Deflations in the structural-chemical organization of the tidemark indicate certain disturbances in the state of the system articular cartilage--subchondral bone. These data can be of prognostic importance. PMID:3606408

  7. Asociación entre porphyromona gingivalis y proteína C reactiva en enfermedades sistémicas inflamatorias Association between porphyromonas gingivalis and C-reactive protein in systemic inflammatory diseases

    Directory of Open Access Journals (Sweden)

    C.M. Ardila Medina

    2010-04-01

    Full Text Available La proteína C reactiva (PCR es un marcador serológico de la inflamación asociado con incremento en el riesgo de enfermedades sistémicas inflamatorias (ESI. La periodontitis también se relaciona con niveles elevados de PCR en adultos y con una reducción de la misma después de su tratamiento. Así, se ha postulado que la PCR puede ser un posible mediador de la asociación entre periodontitis y ESI. Los patógenos periodontales además de inducir inflamación local y destrucción tisular están involucrados en el aumento de la respuesta sistémica inflamatoria e inmunológica. Diferentes autores han investigado la relación entre los anticuerpos para algunos patógenos periodontales y la PCR, pero la asociación se ha notificado firmemente para IgG a Porphyromona gingivalis. Es escasa la evidencia de asociación de una medida directa entre patógenos periodontales y PCR, sin embargo es muy importante debido a que la presencia de anticuerpos no necesariamente es un indicador de infección activa.C-reactive protein (CRP is a serological marker of systemic inflammation that has been associated with increased risk systemic inflammatory diseases. Periodontitis has also been linked to elevated CRP levels in adults as well as with a reduction in PCR after its treatment. It is thus postulated that CRP might be a possible mediator of the association between periodontitis and systemic inflammatory diseases. Periodontal pathogens do not induce only local inflammation and tissue destruction. They are also involved in systemic increases in inflammatory and inmmune responses. Several studies have investigated antibodies to various periodontal pathogens in relation to CRP, but the association has been reported consistently only for IgG to Porphyromonas gingivalis. Evidence is sparse on the association between a direct measure of periodontal pathogens and CRP, while it is more important because the presence of antibody titers is not necessarily indicative

  8. Análise da sintomatologia em pacientes com disfunções intra-articulares da articulação temporomandibular Analysis of symptomatology in patients with intra-articular disorders of the temporomandibular joint

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    Sílvio Henrique de Paula DONEGÁ

    1997-01-01

    Full Text Available Foi realizado estudo analisando a sintomatologia em pacientes com disfunções intra-articulares da articulação temporomandibular. A queixa mais citada foi de dor na região pré-auricular (40,7%. Sintomatologia dolorosa articular (63,2% e ruídos articulares (83,3% foram os achados mais comuns ao exame clínico. Os ruídos articulares mais freqüentes foram os estalos (66,6%. Dor muscular ocorreu, em especial, nos músculos pterigóideo medial e lateral e na inserção do temporal. Houve decréscimo na amplitude para a protrusão dentre os movimentos mandibulares máximosThe study analyzed the symptomatology in patients with intra-articular disorders of the temporomandibular joint. The most frequent complaint was pain in the preauricular region (40.7%. Articular pain (63.2% and articular sounds (83.3% were the most common findings during clinical examination. Muscular pain occurred particularly in the medial and lateral pterygoid muscles and at the insertion of the temporalis muscle. The most frequent articular sound was clicking (66.6%. There was a decrease in extent of protrusion among the mandibular border positions.

  9. Variante faringo-cérvico-braquial del síndrome de Guillain-Barré

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    Iago Pinal-Fernández

    2014-12-01

    Full Text Available El síndrome de Guillain-Barré es una polineuropatía desmielinizante inflamatoria aguda, existiendo variantes locorregionales poco frecuentes como la faringo-cérvico-braquial. Presentamos el caso de un varón de 63 años de edad que acudió a urgencias por debilidad de extremidades superiores y a nivel cervical, con incapacidad para deglutir y masticar, y una insuficiencia respiratoria aguda rápidamente progresiva por debilidad de músculos respiratorios, todo ello secundario a la variante faringo-cérvico-braquial del síndrome de Guillain-Barré. Esta variante, aunque poco frecuente, presenta un patrón clínico y unos criterios diagnósticos bien definidos, importantes de reconocer para poder así iniciar de forma precoz el tratamiento y mejorar el pronóstico, no siempre favorable, de estos pacientes.

  10. Inestabilidad compleja del codo

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    Héctor Gabriel Díaz Carrillo

    2014-08-01

    Full Text Available La inestabilidad compleja del codo es de reciente descripción y controversial en sus resultados; es el estado que se deriva del daño estructural y funcional, producido por la incongruencia de las superficies articulares y las estructuras ligamentosas que estabilizan el codo. Se realizó un estudio descriptivo prospectivo, en el período comprendido entre enero de 2011 y abril de 2013, en una muestra no probabilística de ocho pacientes (diez codos, seleccionados según criterios de inclusión y exclusión. Los objetivos fundamentales del estudio fueron: la actualización de conocimientos para el manejo de la enfermedad y la caracterización de los resultados obtenidos en los afectados por esta dolencia que fueron operados en el Hospital Dr. Ernesto Guevara de la Serna de la provincia de Las Tunas. Se analizaron los datos mediante técnicas estadísticas descriptivas y se realizó la evaluación clínica y radiográfica de los lesionados. El tratamiento se ejecutó según los hallazgos y consistió en: reparación ligamentosa, actuación sobre las partes óseas dañadas y colocación de osteosíntesis diversas. La edad promedio fue de 39,2 años y predominó el sexo masculino. A todos se les practicó reparación ligamentosa, siete cupulectomías y seis aplicaciones de cerclajes anti-distractores. Existieron dos reluxaciones y una sepsis local. La amplitud de movimientos fue aceptable dentro del rango compatible, con una buena función ergonómica; de acuerdo a las comparaciones bibliográficas actualizadas que se realizaron. La fijación y reparación de los estabilizadores del codo brindan buenos resultados funcionales. La sistematización en el manejo de la enfermedad, la detección de complicaciones y el arsenal terapéutico disponible son factores a tener en cuenta

  11. Extra-Articular Lateral Tenodesis for Anterior Cruciate Ligament Deficient Knee: A Case Report

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    Diego García-Germán

    2013-01-01

    Full Text Available We present the case of an extra-articular lateral tenodesis for an anterior cruciate ligament (ACL deficient knee. A 46-year-old male patient sustained an ACL graft rupture after a motorcycle accident. He complained of rotational instability and giving-way episodes. His previous graft was fixed by an intra-articular femoral staple that was not possible to remove at the time of the ACL revision. A modified Lemaire procedure was then performed. He gained rotational stability and was able to resume his sporting activities. We believe that isolated extra-articular reconstructions may still have a role in selected indications including moderate-demand patients complaining of rotational instability after ACL graft failure.

  12. Couple Control Model Implementation on Antagonistic Mono- and Bi-Articular Actuators

    CERN Document Server

    Prattico, Flavio; Yamamoto, Shin-ichiroh

    2014-01-01

    Recently, robot assisted therapy devices are increasingly used for spinal cord injury (SCI) rehabilitation in assisting handicapped patients to regain their impaired movements. Assistive robotic systems may not be able to cure or fully compensate impairments, but it should be able to assist certain impaired functions and ease movements. In this study, a couple control model for lower-limb orthosis of a body weight support gait training system is proposed. The developed leg orthosis implements the use of pneumatic artificial muscle as an actuation system. The pneumatic muscle was arranged antagonistically to form two pair of mono-articular muscles (i.e., hip and knee joints), and a pair of bi-articular actuators (i.e., rectus femoris and hamstring). The results of the proposed couple control model showed that, it was able to simultaneously control the antagonistic mono- and bi-articular actuators and sufficiently performed walking motion of the leg orthosis.

  13. Mapping the Articular Contact Area of the Long Head of the Biceps Tendon on the Humeral Head

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    Brent J. Morris

    2014-01-01

    Full Text Available The purpose of this investigation was to calculate the contact surface area of the long head of the biceps (LHB in neutral position and abduction. We sought to determine whether the LHB articulates with the humeral head in a consistent pattern comparing articular contact area in neutral position and abduction. Eleven fresh frozen matched cadaveric shoulders were analyzed. The path of the biceps tendon on the articular surface of the humeral head and the total articular surface were digitized using a MicronTracker 2 H3-60 three-dimensional optical tracker. Contact surface area was significantly less in abduction than in neutral position (P=0.002 with a median ratio of 41% (36%, 47.5%. Ratios of contact area in neutral position to full articular surface area were consistent between left and right shoulders (rho=1, P=0.017 as were ratios of abduction area to full articular surface area (rho= 0.97, P=0.005. The articular contact surface area is significantly greater in neutral position than abduction. The ratios of articular contact surface areas to total humeral articular surface areas have a narrow range and are consistent between left and right shoulders of the same cadaver.

  14. Treatment of adhesive capsulitis with intra-articular hyaluronate: A systematic review

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    Joshua D Harris

    2011-01-01

    Full Text Available Sodium hyaluronate injection into the glenohumeral joint is a treatment option in the management of adhesive capsulitis of the shoulder. We hypothesized that a systematic review would demonstrate that intra-articular sodium hyaluronate injections would result in significant improvements in passive range-of-motion, shoulder and general clinical outcome measures, and pain scales at short- and mid-term follow-up. Multiple medical databases were searched for levels I-IV evidence with a priori defined specific inclusion and exclusion study criteria. Clinical outcome measures used included Constant score, VAS pain scores, Cho functional scores, JOA scores, and range-of-motion measurements. Seven studies were included (four Level I and three Level IV; 292 subjects, 297 shoulders. Mean subject age was 59.1 years and mean pre-treatment duration of symptoms was 7.3 months. 140 subjects underwent one or multiple hyaluronate injections (120 glenohumeral joint; 20 subacromial bursa. Clinical follow-up was mean 9.0 weeks. Sodium hyaluronate injection into the glenohumeral joint has significantly improved shoulder range-of-motion, constant scores, and pain at short-term follow-up following treatment of adhesive capsulitis. Isolated intra-articular hyaluronate injection has significantly better constant scores than control. Isolated intra-articular hyaluronate injection has equivalent clinical outcomes and range-of-motion compared to intra-articular corticosteroid injection. Intra-articular hyaluronate injection was safe, with no reported complications within the studies in this review. Sodium hyaluronate injection into the glenohumeral joint is a safe, effective treatment in the management of adhesive capsulitis of the shoulder. Short-term evidence indicates that clinical outcomes are better than control and equivalent to intra-articular corticosteroid injection.

  15. Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis.

    Science.gov (United States)

    Goldring, Steven R

    2012-08-01

    The articular cartilage and the subchondral bone form a biocomposite that is uniquely adapted to the transfer of loads across the diarthrodial joint. During the evolution of the osteoarthritic process biomechanical and biological processes result in alterations in the composition, structure and functional properties of these tissues. Given the intimate contact between the cartilage and bone, alterations of either tissue will modulate the properties and function of the other joint component. The changes in periarticular bone tend to occur very early in the development of OA. Although chondrocytes also have the capacity to modulate their functional state in response to loading, the capacity of these cells to repair and modify their surrounding extracellular matrix is relatively limited in comparison to the adjacent subchondral bone. This differential adaptive capacity likely underlies the more rapid appearance of detectable skeletal changes in OA in comparison to the articular cartilage. The OA changes in periarticular bone include increases in subchondral cortical bone thickness, gradual decreases in subchondral trabeular bone mass, formation of marginal joint osteophytes, development of bone cysts and advancement of the zone of calcified cartilage between the articular cartilage and subchondral bone. The expansion of the zone of calcified cartilage contributes to overall thinning of the articular cartilage. The mechanisms involved in this process include the release of soluble mediators from chondrocytes in the deep zones of the articular cartilage and/or the influences of microcracks that have initiated focal remodeling in the calcified cartilage and subchondral bone in an attempt to repair the microdamage. There is the need for further studies to define the pathophysiological mechanisms involved in the interaction between subchondral bone and articular cartilage and for applying this information to the development of therapeutic interventions to improve the

  16. MORPHOMETRIC AND MORPHOLOGICAL STUDY OF ARTICULAR FACETS OF THE THORACOLUMBAR VERTEBRAL COLUMN IN NORTH INDIAN POPULATION

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    Rimpi Gupta

    2015-09-01

    Full Text Available Background: The articular processes of thoracolumbar vertebral column play an important role in weight transmission and determining the range and direction of movements between any two vertebrae. Size of these facets has been correlated with the magnitude of stress imposed on them. Purpose of study: The present study has been conducted on the articular processes of 510 vertebrae (thoracic: 360; lumbar:150 with the aim to provide high quality data sets for constructing the models of spine to study mechanics of spinal instrumentation. The length , width and the distance between the right & left superior & inferior articular processes have been measured with the vernier callipers. The presence/ absence of mamillary tubercle has been observed in the present study. Results: The length of thoracic SAFs was almost same at all levels whereas that of the lumbar SAFs increased gradually from L1-L5. However the width showed a variable trend. In case of thoracic IAFs both these parameters showed a variable trend. Whereas in lumbar region, these increased gradually from L1-L5. The distance between two inferior articular processes was more than that between two superior articular processes at almost all levels except T1-T3 & L1-L4 where reverse was true. The mamillary tubercle/process was altogether absent from T-1 to T-8. From T-9 to T-11, the number of vertebral column showing mamillary tubercle increased from 4-19. However at T-12, it was seen in 29 Vertebral columns. In lumbar region, it was well developed in all vertebrae and termed as mamillary process. Conclusion: The measurements obtained by present study reveals the importance of articular facets in understanding basic spinal mechanics and its application with respect to weight transmission.

  17. Comparison of nonlinear mechanical properties of bovine articular cartilage and meniscus.

    Science.gov (United States)

    Danso, E K; Honkanen, J T J; Saarakkala, S; Korhonen, R K

    2014-01-01

    Nonlinear, linear and failure properties of articular cartilage and meniscus in opposing contact surfaces are poorly known in tension. Relationships between the tensile properties of articular cartilage and meniscus in contact with each other within knee joints are also not known. In the present study, rectangular samples were prepared from the superficial lateral femoral condyle cartilage and lateral meniscus of bovine knee joints. Tensile tests were carried out with a loading rate of 5mm/min until the tissue rupture. Nonlinear properties of the toe region, linear properties in larger strains, and failure properties of both tissues were analysed. The strain-dependent tensile modulus of the toe region, Young's modulus of the linear region, ultimate tensile stress and toughness were on average 98.2, 8.3, 4.0 and 1.9 times greater (p<0.05) for meniscus than for articular cartilage. In contrast, the toe region strain, yield strain and failure strain were on average 9.4, 3.1 and 2.3 times greater (p<0.05) for cartilage than for meniscus. There was a significant negative correlation between the strain-dependent tensile moduli of meniscus and articular cartilage samples within the same joints (r=-0.690, p=0.014). In conclusion, the meniscus possesses higher nonlinear and linear elastic stiffness and energy absorption capability before rupture than contacting articular cartilage, while cartilage has longer nonlinear region and can withstand greater strains before failure. These findings point out different load carrying demands that both articular cartilage and meniscus have to fulfil during normal physiological loading activities of knee joints. PMID:24182695

  18. The intra-articular distance within the TMJ during free and loaded closing movements.

    Science.gov (United States)

    Huddleston Slater, J J; Visscher, C M; Lobbezoo, F; Naeije, M

    1999-12-01

    Previous studies on free opening and closing movements of the mandible have demonstrated that the opening movement traces of the condylar kinematic center (i.e., the condylar point for which the protrusive and the opening movement traces coincide) lie closer to the articular eminence than the closing traces. This indicates the presence of an intra-articular distance within the joint during free closing. Since the mandible behaves like a class III biomechanical lever, a counteracting mechanical load on the mandible during closing will press the condyle-disc complex against the articular eminence. Therefore, in this study the hypothesis was tested that the difference between opening and closing movement traces of the kinematic center is reduced when the closing movements are counteracted by a mechanical load. From 10 healthy participants, 20-second movement recordings were obtained by a six-degrees-of-freedom opto-electronic jaw movement recording system (OKAS-3D) for three types of movements: (1) free opening and closing movements, (2) free opening and loaded closing movements (i.e., the participants closed against a small or high manually applied downward-directed force to the chin), and (3) gum chewing. Off-line, the opening and closing movement traces of the kinematic center were reconstructed, and the average difference between the traces (the intra-articular distance) was calculated. The average intraarticular distance was significantly smaller during loaded closing than during free closing, whereas no significant differences were found in the intra-articular distances between the loaded situations of low and high manual loading and contralateral chewing (ANOVA and post hoc Bonferroni multiple comparisons of means test, p<0.005). In conclusion, loading of the mandible during closing movements reduces the intra-articular distance within the temporomandibular joint. PMID:10598911

  19. Manejo laparoscópico de la enfermedad pélvica inflamatoria severa: reporte de tres casos y revisión de la literatura Laparoscopic management of severe pelvic inflammatory disease: a report of three cases and a literature review

    Directory of Open Access Journals (Sweden)

    Gustavo Adolfo Calle-Gómez

    2011-06-01

    Full Text Available Objetivo: hacer una revisión de la literatura sobre la utilidad de la laparoscopia en el tratamiento del absceso tubovárico en términos de mejoría, estancia y fertilidad posterior. Materiales y métodos: se presentan tres casos de pacientes con enfermedad pélvica inflamatoria severa que consultaron a una institución privada de referencia ubicada en Medellín (Colombia, a quienes se les practicó una laparoscopia operatoria, además de la administración de un antibiótico parenteral como manejo. Se realizó una búsqueda en la base de datos Medline vía PubMed con las palabras clave: “tubo-ovarian abscess, treatment, laparoscopy, fertility”. Se realizó además una búsqueda de textos clásicos y guías de manejo. Resultados: se encontraron 49 artículos de los cuales 13 eran relevantes al problema en cuestión. De estas publicaciones, 8 eran artículos de revisión, 4 series de casos, y 1 un estudio de cohortes retrospectivas. Conclusión: el manejo laparoscópico conservador del absceso tubovárico en el período inicial de la enfermedad, adicional a los antibióticos, surge como una alternativa que podría mejorar los resultados a corto y largo plazo. Se requieren estudios de alta calidad que respalden esta observación.Objective: carrying out a literature review about the usefulness of laparoscopy in treating tuboovarian abscesses in terms of improvement, hospital stay and subsequent fertility. Materials and methods: three cases of patients suffering from severe pelvic inflammatory disease are presented; they consulted at a private reference institution in Medellín, Colombia, and were then submitted to laparoscopy, accompanied by parenteral antibiotics as management. A search was made in the Medline database via PubMed using the following key words: “tubo-ovarian abscess, treatment, laparoscopy, fertility.” A search was also made in classical texts on the subject and management guidelines. Results: 49 pertinent articles were

  20. Interdependência da lateralidade com a estabilidade articular do membro inferior

    OpenAIRE

    Atalaia, Tiago João Viegas

    2015-01-01

    A presença de dominância de um membro inferior em relação ao seu contra lateral, leva a esperar a existência de diferenças funcionais. O objetivo desta tese visou a identificação de diferenças entre membro inferior dominante (DOM) e não dominante (NDOM), no que diz respeito à estabilidade articular (JS), avaliada por medidas de rigidez dinâmica articular (DJS), rigidez vertical (KVERT) ou rigidez de membro inferior (KLEG). A integração de elementos conceptuais e metodológicos foi desenvolvida...

  1. MRI features of three paediatric intra-articular synovial lesions: a comparative study

    Energy Technology Data Exchange (ETDEWEB)

    Kan, J.H. [Monroe Carell Jr. Children' s Hospital at Vanderbilt, Nashville, TN (United States)], E-mail: herman.kan@vanderbilt.edu; Hernanz-Schulman, M. [Monroe Carell Jr. Children' s Hospital at Vanderbilt, Nashville, TN (United States); Damon, B.M.; Yu, Chang [Vanderbilt University, Nashville, TN (United States); Connolly, S.A. [Boston Children' s Hospital, Boston, IL (United States)

    2008-07-15

    Aim: To determine reliable magnetic resonance imaging (MRI) features differentiating three paediatric intra-articular congenital or neoplastic synovial lesions that contain blood products, from post-traumatic or haemorrhagic inflammatory processes. Materials and methods: This was a retrospective review of MRI findings of 22 paediatric intra-articular congenital or neoplastic synovial lesions, including venous malformation (VM) (n = 12), pigmented villonodular synovitis (PVNS; n = 8), and synovial sarcoma (SS; n = 2). These MRI features were compared with 22 paediatric post-traumatic or inflammatory intra-articular processes containing blood products and producing mass effect. The following imaging features were assessed: presence of a discrete mass, extension, extra-articular oedema, susceptibility, joint effusion, and size. Fisher's exact test was used and results were considered statistically significant when p < 0.05. Results: The three intra-articular synovial lesions, compared with controls, were more likely to directly invade osseous structures when a discrete mass was present (13/16, 81.3% versus 1/9, 11.1%; p < 0.002) and extend into extra-articular soft tissues (13/21, 61.9% versus 2/17, 11.8%; p < 0.003), but were less likely to show extra-articular oedema (3/22, 13.6% versus 13/22, 59.1%; p < 0.004), a joint effusion (10/22,45.5% versus 19/22, 86.4%, p < 0.01), susceptibility within a joint effusion (0/22, 0% versus 11/22, 40.9%; p = 0.00), osseous oedema (3/16, 18.8% versus 7/9, 77.8%; p < 0.009), and synovial enhancement (8/21, 38.1% versus 14/16, 87.5%; p < 0.003). VMs had characteristic tubular vessels with internal fluid-fluid levels (11/12) that extended into bone (10/12) and extracapsular soft tissues (11/12). Conclusion: Our study indicates that, despite the overlapping presence of haemorrhagic products, intra-articular VM, PVNS, and SS show MRI features that permit distinction from acquired post-traumatic and haemorrhagic inflammatory

  2. MRI features of three paediatric intra-articular synovial lesions: a comparative study

    International Nuclear Information System (INIS)

    Aim: To determine reliable magnetic resonance imaging (MRI) features differentiating three paediatric intra-articular congenital or neoplastic synovial lesions that contain blood products, from post-traumatic or haemorrhagic inflammatory processes. Materials and methods: This was a retrospective review of MRI findings of 22 paediatric intra-articular congenital or neoplastic synovial lesions, including venous malformation (VM) (n = 12), pigmented villonodular synovitis (PVNS; n = 8), and synovial sarcoma (SS; n = 2). These MRI features were compared with 22 paediatric post-traumatic or inflammatory intra-articular processes containing blood products and producing mass effect. The following imaging features were assessed: presence of a discrete mass, extension, extra-articular oedema, susceptibility, joint effusion, and size. Fisher's exact test was used and results were considered statistically significant when p < 0.05. Results: The three intra-articular synovial lesions, compared with controls, were more likely to directly invade osseous structures when a discrete mass was present (13/16, 81.3% versus 1/9, 11.1%; p < 0.002) and extend into extra-articular soft tissues (13/21, 61.9% versus 2/17, 11.8%; p < 0.003), but were less likely to show extra-articular oedema (3/22, 13.6% versus 13/22, 59.1%; p < 0.004), a joint effusion (10/22,45.5% versus 19/22, 86.4%, p < 0.01), susceptibility within a joint effusion (0/22, 0% versus 11/22, 40.9%; p = 0.00), osseous oedema (3/16, 18.8% versus 7/9, 77.8%; p < 0.009), and synovial enhancement (8/21, 38.1% versus 14/16, 87.5%; p < 0.003). VMs had characteristic tubular vessels with internal fluid-fluid levels (11/12) that extended into bone (10/12) and extracapsular soft tissues (11/12). Conclusion: Our study indicates that, despite the overlapping presence of haemorrhagic products, intra-articular VM, PVNS, and SS show MRI features that permit distinction from acquired post-traumatic and haemorrhagic inflammatory lesions

  3. Rigidez articular - doi: 10.5102/ucs.v3i1.550

    Directory of Open Access Journals (Sweden)

    Gustavo Rocha Velloso

    2008-04-01

    Full Text Available As causas da rigidez articulatória devem ser bem avaliadas quando presentes na história clínica dos pacientes. Fatores intrínsecos e extrínsecos devem ser considerados com cuidado. A qualidade da superfície articulatória, o nivelamento da cartilagem e a fibrose são causas comuns da queixa de rigidez articular. O aumento do líquido sinovial e a hipertrofia sinovial podem ser fatores importantes na restrição do movimento articular.

  4. A Case of Recurrent Acute Pancreatitis Due to Intra-Articular Corticosteroid Injection

    Directory of Open Access Journals (Sweden)

    Patompong Ungprasert

    2014-03-01

    Full Text Available Context Corticosteroid is a well-established cause of drug-induced pancreatitis. However, acute pancreatitis from intraarticularinjection of corticosteroid has never been described. Case report A 69-year-old male presented with acuteabdominal pain and was diagnosed with acute pancreatitis. The patient had one episode of acute pancreatitis two yearearlier. Both episodes occurred after intra-articular cortisone injection. Investigations for other causes of pancreatitis werenegative. Conclusion We report the first case of acute pancreatitis from intra-articular corticosteroid injection. Physiciansshould be aware of this adverse reaction of corticosteroid that can even occur with local administration.

  5. Minced articular cartilage--basic science, surgical technique, and clinical application.

    Science.gov (United States)

    McCormick, Frank; Yanke, Adam; Provencher, Matthew T; Cole, Brian J

    2008-12-01

    Minced articular cartilage procedures are attractive surgical approaches for repairing articular cartilage, as they are 1-staged, autologous, and inserted on a carrier that can potentially be placed arthroscopically. The principle of mincing the autologous donor cartilage is to create a larger surface area for cartilage expansion. Placement on a scaffold carrier allows for a chondro-inductive and chondro-conductive milieu. Early animal and preclinical models have demonstrated hyaline-like tissue repair. Further work needs to be conducted in this promising approach. PMID:19011553

  6. Intra-articular Duration of Durolane™ after Single Injection into the Rabbit Knee

    OpenAIRE

    Edsman, Katarina; Hjelm, Roland; Lärkner, Helena; Nord, Lars I.; Karlsson, Anders; Wiebensjö, Åsa; Höglund, A. Urban; Kenne, Anne Helander; Näsström, Jacques

    2011-01-01

    Objective: The aim of the present study was to investigate the intra-articular duration of Durolane™ in a rabbit model to allow comparison between Durolane™ residence time and data reported for other hyaluronic acid products as well as native hyaluronic acid. Design: 14C-labeled Durolane™ was manufactured by labeling the cross-linker used for stabilization. A single injection of approximately 0.3 mL 14C-labeled Durolane™ was administered intra-articularly in both knee joints of male New Zeala...

  7. Cirugía bariátrica en enfermedad inflamatoria intestinal: presentación de un caso clínico y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Carmen Tenorio Jiménez

    2013-06-01

    Full Text Available La Enfermedad Inflamatoria Intestinal (EII raramente se asocia a obesidad, ya que la malabsorción es una característica frecuente de este grupo de patologías (1. Sin embargo, algunos pacientes pueden padecer obesidad mórbida asociada a complicaciones y refractaria a tratamiento dietético y beneficiarse de la cirugía bariátrica. Incluso se ha postulado que podría producirse una mejoría de la EII al disminuir los marcadores inflamatorios tras la cirugía (2. No obstante, los pacientes pueden experimentar mayor incidencia de complicaciones tras la cirugía en el contexto de terapias inmunosupresoras y agravamiento de la malabsorción previa. Por ello, si se realiza la cirugía, la cuidadosa selección de los pacientes y la individualización de la técnica a realizar son imprescindibles. Presentamos una paciente diagnosticada de Colitis Ulcerosa que presenta desnutrición proteica severa tras cirugía bariátrica tipo derivación bilio-pancreática y realizamos una revisión de la literatura disponible.

  8. Long-Term Follow-Up of 24.5 Years After Intra-Articular Anterior Cruciate Ligament Reconstruction With Lateral Extra-Articular Augmentation

    OpenAIRE

    PERNIN, Jérôme; Verdonk, Peter C. M.; AIT SI SELMI, Tarik; Massin, Philippe; Neyret, Philippe

    2010-01-01

    Background: Many studies have reported successful outcomes 10 to 15 years after ACL reconstruction. However, few authors report results at ultra long-term follow-up (more than 20 years of follow-up). Purpose: The aim of this study was to determine how the status of the medial meniscus and the medial compartment articular cartilage observed at the time of ACL reconstruction affects results more than 24 years after surgery. This article examines longterm outcome of ACL reconstruction with extra...

  9. The Safety and Effectiveness of Single and Repeat Dosing of Intra-Articular Anti-Tumour Necrosis Factor Treatment after Failure of Intra-Articular Steroids

    OpenAIRE

    Chia, Justin; POPE, JANET

    2011-01-01

    Objectives: To determine if intra-articular (ia) anti-tumour necrosis factor (TNF) yielded benefit in patients failing ia steroid injections and determine the safety and durability of single and repeated ia anti-TNF treatment in inflammatory arthritis. Methods: Patients with inflammatory arthritis having one or two active joints, and having failed previous ia steroids were injected with ia adalimumab or ia etanercept mixed with triamcinolone and lidocaine via a retrospective chart audit. Resu...

  10. Análisis de la reacción inflamatoria y los procesos degenerativos provocados por la inyección intracerebroventricular de neuraminidasa en rata

    OpenAIRE

    Granados-Durán, Pablo

    2014-01-01

    Las infecciones víricas y bacterianas del sistema nervioso central (SNC) y la neuroinflamación han sido relacionadas en los últimos años con en el desarrollo de ciertas enfermedades neurodegenerativas, tales como la esclerosis múltiple, la enfermedad de Alzheimer, la esclerosis lateral amiotrófica o trastornos neurocognitivos como la demencia asociada al VIH o la esquizofrenia. Muchas de estas enfermedades continúan hoy sin tratamiento, incluyendo aquellas que son sospechosas de ser consecuen...

  11. Efecto antiinflamatorio y antioxidante del extracto hidroalcohólico de Petiveria alliacea

    Directory of Open Access Journals (Sweden)

    César Zaa

    2013-06-01

    Full Text Available Los radicales libres y el daño oxidativo están relacionados con la muerte celular, siendo la peroxidación lipídica un mecanismo que lleva a la destrucción oxidativa de la membrana celular. Además, en procesos inflamatorios, uno de los primeros estadios es la permeabilidad vascular incrementada (formación del edema seguido de la extravasación de los fluídos, migración de leucocitos al sitio dañado y liberación de proteínas pro-inflamatorias. Evaluamos el efecto antioxidante y antiinflamatorio para Petiveria alliacea“mucura”. Para el efecto antioxidante, se evaluó la formación de especies reactivas al ácido tiobarbitúrico como indicador de la peroxidación lipídica. Dosis 200mg/mL de Petiveria alliaceadisminuyó significativamente en un 42% los niveles de MDA comparado con el agua (control negativo. En la evaluación antiinflamatoria, se indujo la inflamación por inyección de car-ragenina (solución al 1%, en la parte subplantar de ratones y en la “bolsa de aire subcutánea” de ratas para la inflamación aguda y crónica respectivamente. En la evaluación antiinflamatoria hay una máxima reducción del edema en un 23,26% a las 4 horas del tratamiento. Para la inflamación crónica hay una reducción del 25,9% y 29,5% del peso y volumen del exudado extraído, respectivamente, así como una reducción del 24% de peso de tejido fibroso. Estos resultados evidencian efecto antioxidante y antiinflamatorio de Petiveria alliacea.

  12. Accuracy of ultrasound-guided injections of thoracolumbar articular process joints in horses

    DEFF Research Database (Denmark)

    Fuglbjerg, Vibeke; Nielsen, J.V.; Thomsen, Preben Dybdahl;

    2010-01-01

    Reasons for performing study: Arthrosis of the articular process joints (APJs) in the caudal thoracolumbar region of horses may cause back pain and subsequent reduced performance or lameness. Ultrasound-guided injections of the APJs of the equine back have been described only briefly in the liter......Reasons for performing study: Arthrosis of the articular process joints (APJs) in the caudal thoracolumbar region of horses may cause back pain and subsequent reduced performance or lameness. Ultrasound-guided injections of the APJs of the equine back have been described only briefly...... unrelated to back problems. The backs were subsequently dissected to verify the location of the injectate in relation to the APJs. Results: Twenty-seven percent of the injections were found to be intra-articular and a total of 77% found to be within 2 mm of the joint capsule including the intra......-articular deposits. Application of a medial approach and 18 gauge needle were significantly associated with an intra-articulr injection or deposition close to the joint capsule. Operator, APJ (location) and back number (chronological) did not significantly affect the accuracy of injection. Conclusions and potential...

  13. Effect of corticosteroids on articular cartilage: have animal studies said everything?

    Science.gov (United States)

    Vandeweerd, Jean-Michel; Zhao, Yang; Nisolle, Jean-François; Zhang, Wenhui; Zhihong, Liu; Clegg, Peter; Gustin, Pascal

    2015-10-01

    Intra-articular (IA) corticosteroids (CS) have been used in the treatment of osteoarthritis for many years, although their effects on articular cartilage are not fully understood. To identify whether previous animal studies have provided enough evidence about the effects of CS, we undertook a systematic review that identified 35 relevant in vivo animal experimental studies between 1965 and 2014 assessing the effects of CS on either normal cartilage, or in either induced osteoarthritis (OA) or synovitis. The quality of the methodology was assessed. Deleterious effects, both structural and biochemical, have mainly been reported in rabbits and are associated with frequent administration of CS, sometimes at high dose and with systemic side effects. In dogs, four identified studies concluded that there were beneficial effects with methylprednisolone acetate (MPA) and triamcinolone hexacetonide therapy. In horses, MPA was mostly deleterious, while triamcinolone acetonide had positive effects in one study highly rated at quality assessment. However, many methodological weaknesses have been identified, such as the lack of pharmacokinetic and pharmocodynamics data and the large variation in doses between studies, the limited selection criteria at baseline, the absence of blinding, and the lack of statistics or appropriate controls for testing the effects of the vehicle of the drug. Those methodological weaknesses weaken the conclusions of numerous studies that assess beneficial or deleterious effects of CS on articular cartilage. Animal studies have not yet provided definitive data, and further research is required into the role of CS in articular pathobiology. PMID:26211421

  14. Tumoral calcinosis peri articular in infants: study by conventional radiology and CT

    International Nuclear Information System (INIS)

    Tumoral calcinosis is an uncommon disease of poorly defined origin that effects the peri articular soft tissue. It is very rarely located in the region of the knee except in children. We present a case occurring in the knee in which the course of both the clinical and radiological signs was favorable. (Author)

  15. Increasing lateral tibial slope: is there an association with articular cartilage changes in the knee?

    Energy Technology Data Exchange (ETDEWEB)

    Khan, Nasir; Shepel, Michael; Leswick, David A.; Obaid, Haron [University of Saskatchewan, Department of Medical Imaging, Royal University Hospital, and College of Medicine, Saskatoon, Saskatchewan (Canada)

    2014-04-15

    The geometry of the lateral tibial slope (LTS) plays an important role in the overall biomechanics of the knee. Through this study, we aim to assess the impact of LTS on cartilage degeneration in the knee. A retrospective analysis of 93 knee MRI scans (1.5 T or 3 T) for patients aged 20-45 years with no history of trauma or knee surgery, and absence of internal derangement. The LTS was calculated using the circle method. Chondropathy was graded from 0 (normal) to 3 (severe). Linear regression analysis was used for statistical analysis (p < 0.05). In our cohort of patients, a statistically significant association was seen between increasing LTS and worsening cartilage degenerative changes in the medial patellar articular surface and the lateral tibial articular surface (p < 0.05). There was no statistically significant association between increasing LTS and worsening chondropathy of the lateral patellar, medial trochlea, lateral trochlea, medial femoral, lateral femoral, and medial tibial articular surfaces. Our results show a statistically significant association between increasing LTS and worsening cartilage degenerative changes in the medial patella and the lateral tibial plateau. We speculate that increased LTS may result in increased femoral glide over the lateral tibial plateau with subsequent increased external rotation of the femur predisposing to patellofemoral articular changes. Future arthroscopic studies are needed to further confirm our findings. (orig.)

  16. Articular cartilage lesions of the knee. MRI of tibial condylar fractures

    International Nuclear Information System (INIS)

    Lesions of the articular cartilage are rarely observed in convensional radiography and CT, and may be one of the most important prognostic factors in assessing traumatic or degenerative disorders at the knee joints. To discuss the usefulness of MRI for detecting cartilage lesions, knees with tibial condylar fractures were examined with MRI. 47 patients with tibial condylar fractures were reviewed 4 months to 15 years (average of 4 years) after the fractures. Good to excellent results were obtained in 91.5% of them. It is known that anatomical reduction of conventional radiography is not consistent with the clinical outcome, because radiography can show the changes of bones only. However, the results of MRI examinations are consistent with the clinical outcome, because they can directly show the state of the articular surface, such as defects of cartilage in the joint. In my study, no abnormality of well repaired joint surfaces employing MRI were observed in the patients with excellent or good results, and various degrees of cartilage lesions were detected using MRI in the other patients. MRI is a useful method for noninvasively determining the integrity of articular cartilage, detecting cartilage lesions and degenerative disorders of tibial condyle, and also may be useful in studying and following the natural aging process in osteoarthritis following intra-articular fractures. (author) 52 refs

  17. Articular Cartilage Thickness Measured with US is Not as Easy as It Appears

    DEFF Research Database (Denmark)

    Torp-Pedersen, Søren; Bartels, E. M.; Wilhjelm, Jens E.;

    2011-01-01

    Background: Theoretically, the high spatial resolution of US makes it well suited to monitor the decrease in articular cartilage thickness in osteoarthritis. A requirement is, however, that the borders of the cartilage are correctly identified and that the cartilage ismeasured under orthogonal in...

  18. Articular cartilage thickness measured with US is not as easy as it appears

    DEFF Research Database (Denmark)

    Torp-Pedersen, S; Bartels, E M; Wilhjelm, Jens E.;

    2011-01-01

    Theoretically, the high spatial resolution of US makes it well suited to monitor the decrease in articular cartilage thickness in osteoarthritis. A requirement is, however, that the borders of the cartilage are correctly identified and that the cartilage is measured under orthogonal insonation. I...

  19. Intra-articular apatite deposition in mixed connective tissue disease: crystallographic and technetium scanning characteristics.

    OpenAIRE

    Hutton, C W; Maddison, P J; Collins, A J; Berriman, J A

    1988-01-01

    An acute arthritis in a patient with mixed connective tissue disease (MCTD) was found to be associated with intra-articular deposition of carbonated hydroxyapatite crystals. A technetium hydroxymethylene diphosphonate bone scan showed intense uptake in the delayed phase scan of the affected joints. Synovial fluid analysis demonstrated uptake of the radiopharmaceutical drug directly onto the crystals.

  20. MRI of articular cartilaginous lesions. MRI findings in osteoarthritis of the knee joint

    International Nuclear Information System (INIS)

    An investigation was carried out to assess the usefulness of magnetic resonance imaging for imaging of the knee joint, especially for detecting articular cartilaginous lesions associated with osteoarthritis of the knee. A total of 141 patients with osteoarthritis were examined (23 males, 118 females). Their age range was 40-93 (mean age 66.2). Using radiotherapy examinations, patients were classified according to Hokkaido University Classification Criteria; 22, 49, 46, 16, and 8 patients were classified as Type I, II, III, IV and V, respectively. Articular cartilage defects were examined using MRI, and the number of such defects increased as the X-ray stage progressed. The appearance of a low signal intensity area in the bone marrow was examined using MRI, and the number of patients observed to have such areas increased as the x-ray stages progressed. JOA OA scores were significantly low for patients with meniscal tears. Patients were classified and results reviewed using MRI examinations. Classification by MRI of articular cartilage lesions correlated with the JOA OA scores. Low signal intensity areas in the bone marrow were frequently observed in advanced osteoarthritis cases, and there was correlation between FTA and MRI classifications of these areas. MRI is extremely valuable in detecting articular cartilage lesions in the knee joint, showing those lesions which cannot be detected by conventional radiography examinations. Thus, MRI is judged to be a clinically useful method for diagnosis of osteoarthritis. (author)

  1. Noncontact evaluation of articular cartilage degeneration using a novel ultrasound water jet indentation system.

    Science.gov (United States)

    Lu, M-H; Zheng, Y P; Huang, Q-H; Ling, C; Wang, Q; Bridal, L; Qin, L; Mak, A

    2009-01-01

    We previously reported a noncontact ultrasound water jet indentation system for measuring and mapping tissue mechanical properties. The key idea was to utilize a water jet as an indenter as well as the coupling medium for high-frequency ultrasound. In this paper, the system was employed to assess articular cartilage degeneration, using stiffness ratio as an indicator of the mechanical properties of samples. Both the mechanical and acoustical properties of intact and degenerated bovine patellar articular cartilage (n = 8) were obtained in situ. It was found that the stiffness ratio was reduced by 44 +/- 17% after the articular cartilage was treated by 0.25% trypsin at 37 degrees C for 4 h while no significant difference in thickness was observed between the intact and degenerated samples. A significant decrease of 36 +/- 20% in the peak-to-peak amplitude of ultrasound echoes reflected from the cartilage surface was also found for the cartilage samples treated by trypsin. The results also showed that the stiffness obtained with the new method highly correlated with that measured using a standard mechanical testing protocol. A good reproducibility of the measurements was demonstrated. The present results showed that the ultrasound water jet indentation system may provide a potential tool for the non-destructive evaluation of articular cartilage degeneration by simultaneously obtaining mechanical properties, acoustical properties, and thickness data. PMID:19011965

  2. THE FUNCTIONAL EFFECTIVENESS OF A CELL-ENGINEERED CONSTRUCT FOR THE REGENERATION OF ARTICULAR CARTILAGE

    Directory of Open Access Journals (Sweden)

    V. I. Sevastianov

    2015-04-01

    Full Text Available The aim of this study is an analysis of the functional effectiveness of a biomedical cell product consisting of a biopolymer microheterogeneous collagen-containing hydrogel (BMCH, human adipose-derived mesenchymal stromal cells (hADMSCs, and chondrogenic induction medium in the regeneration of articular cartilage. Materials and methods. The test model of the adjuvant arthritis was used (female Soviet Chinchilla rabbits with the further development into osteoarthrosis (OA combined with the clinical, biochemical, radiological, and histochemical trials. Results. On Day 92 of the OA model it has been found that the intra-articular introduction of a BMCH with hADMSCs into the left knee joint (n = 3 30 days after the OA modeling, as opposed to the right joint (negative control, n = 3, stimulates the regenerative processes of the cartilaginous tissue structure characterized by the formation of chondrocyte «columns», the emergence of isogenic groups in the intracellular matrix and the regeneration of its structure. Upon the intra-articular introduction of a BMCH (n = 3 such effects are markedly less pronounced. Conclusions. A significant regenerative potential of a cell-engineered construct of human articular tissue (CEC ATh has been proven. It is possible to presume that biostimulating properties of CEC ATh are due to the activating effect of a biomedical cell product on the stem cell migration processes from the surrounding tissue into the injured area with their subsequent differentiation. 

  3. Topographical mapping of biochemical properties of articular cartilage in the equine fetlock joint

    NARCIS (Netherlands)

    Brama, P.A.J.; Tekoppele, J.M.; Bank, R.A.; Karssenberg, D.; Barneveld, A.; Weeren, P.R. van

    2000-01-01

    The aim of this study was to evaluate topographical differences in the biochemical composition of the extracellular matrix of articular cartilage of the normal equine fetlock joint. Water content, DNA content, glycosaminoglycan (GAG) content and a number of characteristics of the collagen network (t

  4. Is nephrolithiasis an unrecognized extra-articular manifestation in ankylosing spondylitis?

    DEFF Research Database (Denmark)

    Jakobsen, Ane Krag; Jacobsson, Lennart T H; Patschan, Oliver;

    2014-01-01

    BACKGROUND: Ankylosing spondylitis (AS) is associated with several extra-articular manifestations. Nephrolithiasis (NL) has not been recognized as one of those, however, several factors known to increase the risk of NL are at play in AS patients. The objective was to estimate rates and predictors...

  5. Surgical treatment of a comminuted articular fracture of the accessory carpal bone in a thoroughbred horse

    International Nuclear Information System (INIS)

    The clinical, radiographic and ultrasonographic findings in a case ofa comminuted articular fracture of the accessory carpal bone of a thoroughbred chaser are described, and its surgical treatment and aftercare are detailed. The horse made an uneventful recovery and successfully returned to racing

  6. Evaluation of influence of proteoglycans on hydration of articular cartilage with the use of ultrasound

    Directory of Open Access Journals (Sweden)

    Yi-yi YANG

    2015-04-01

    Full Text Available Objective To monitor the changes in hydration behaviour of articular cartilage induced by degradation of proteoglycans, and to explore the effect of proteoglycans on hydration behaviour of articular cartilage by using high-frequency ultrasound. Methods Twelve porcine patellae with smooth cartilage surface were prepared and equally divided into two groups: normal group without any enzyme treatment, and trypsin group they were treated with 0.25% trypsin for 8h to digest proteoglycan in the cartilage. The hydration behaviour of the cartilage tissue was scanned by high-frequency ultrasound system with a central frequency of 25MHz. Parameters including cartilage hydration strain and cartilage thickness were measured. The histopathological changes in the articular cartilage were observed under a light microscope. Results It took approximately 20min to reach equilibrium during the hydration process in the normal cartilages, while proteoglycan-degraded cartilage took only about 5min to achieve equilibrium. The equilibrium strain of normal cartilage was 3.5%±0.5%. The degradation of proteoglycans induced a significant decrease in equilibrium strain (1.8%±0.2%, P0.05. Conclusion Proteoglycans play an important role in hydration behaviour of articular cartilage. The degradation of proteoglycans could induce degeneration of cartilage structure and decrease in hydration behaviour after dehydration. DOI: 10.11855/j.issn.0577-7402.2015.03.03

  7. Glucosamine:chondroitin or ginger root extract have little effect on articular cartilage in swine

    Science.gov (United States)

    Sows are culled at a high rate from breeding herds due to musclo-skeletal problems and lameness. Research in our laboratory has shown that even first-parity sows have significant amounts of osteochondritic lesions of their articular cartilage. Glusoamine chondroitin and ginger root extract have both...

  8. Adverse effects of extra-articular corticosteroid injections: A systematic review

    NARCIS (Netherlands)

    A. Brinks (Tineke); B.W. Koes (Bart); A.C. Volkers (Aloysius); J.A.N. Verhaar (Jan); S.M. Bierma-Zeinstra (Sita)

    2010-01-01

    textabstractBackground. To estimate the occurrence and type of adverse effects after application of an extra-articular (soft tissue) corticosteroid injection. Methods. A systematic review of the literature was made based on a PubMed and Embase search covering the period 1956 to January 2010. Case re

  9. Increasing lateral tibial slope: is there an association with articular cartilage changes in the knee?

    International Nuclear Information System (INIS)

    The geometry of the lateral tibial slope (LTS) plays an important role in the overall biomechanics of the knee. Through this study, we aim to assess the impact of LTS on cartilage degeneration in the knee. A retrospective analysis of 93 knee MRI scans (1.5 T or 3 T) for patients aged 20-45 years with no history of trauma or knee surgery, and absence of internal derangement. The LTS was calculated using the circle method. Chondropathy was graded from 0 (normal) to 3 (severe). Linear regression analysis was used for statistical analysis (p < 0.05). In our cohort of patients, a statistically significant association was seen between increasing LTS and worsening cartilage degenerative changes in the medial patellar articular surface and the lateral tibial articular surface (p < 0.05). There was no statistically significant association between increasing LTS and worsening chondropathy of the lateral patellar, medial trochlea, lateral trochlea, medial femoral, lateral femoral, and medial tibial articular surfaces. Our results show a statistically significant association between increasing LTS and worsening cartilage degenerative changes in the medial patella and the lateral tibial plateau. We speculate that increased LTS may result in increased femoral glide over the lateral tibial plateau with subsequent increased external rotation of the femur predisposing to patellofemoral articular changes. Future arthroscopic studies are needed to further confirm our findings. (orig.)

  10. Intra-articular drug injections in the combination treatment of rheumatic diseases

    Directory of Open Access Journals (Sweden)

    Yu. A. Olyunin

    2015-01-01

    Full Text Available In clinical practice, intra-articular injections of glucocorticoids (GC are widely used to treat chronic joint inflammatory diseases, osteoarthritis (OA, and extra-articular soft tissue involve-ment. GCs given to patients with chronic arthritis may rapidly suppress joint inflammatory changes and ensure significant clinical improvements well before there is a benefit of prescribed disease-modifying antirheumatic drugs. According to the clinical features of disease, GCs may be used for systemic or local treatment in each specific case and a combination of these two treatments may be performed in some patients. In OA patents, the effect of intra-articular GC injections is less sustained than in those with joint inflammatory diseases and it persists for an average of about 3 weeks. Intra-articular hyaluronic acid is likely to be a more promising treatment for OA. It may also relieve pain considerably and improve joint functions. At the same time the highest effect was noted between weeks 5 and 13 after injection, but improvement also persisted after 14–26 weeks or longer in a number of cases.

  11. Cycloolefin-Copolymer/Polyethylene (COC/PE) Blend Assists with the Creation of New Articular Cartilage

    Czech Academy of Sciences Publication Activity Database

    Petrtýl, M.; Bastl, Zdeněk; Kruliš, Zdeněk; Hulejová, H.; Polanská, M.; Lísal, J.; Danešová, J.; Černý, P.

    294-I, - (2010), s. 120-132. ISSN 1022-1360 R&D Projects: GA ČR GA106/06/0761 Institutional research plan: CEZ:AV0Z40400503; CEZ:AV0Z40500505 Keywords : articular cartilage * biomaterials * cycloolefin-copolymer blend Subject RIV: CF - Physical ; Theoretical Chemistry

  12. Preliminary investigation of intrinsic UV fluorescence spectroscopic changes associated with proteolytic digestion of bovine articular cartilage

    Science.gov (United States)

    Lewis, William; Padilla-Martinez, Juan-Pablo; Ortega-Martinez, Antonio; Franco, Walfre

    2016-03-01

    Degradation and destruction of articular cartilage is the etiology of osteoarthritis (OA), an entity second only to cardiovascular disease as a cause of disability in the United States. Joint mechanics and cartilage biochemistry are believed to play a role in OA; an optical tool to detect structural and chemical changes in articular cartilage might offer benefit for its early detection and treatment. The objective of the present study was to identify the spectral changes in intrinsic ultraviolet (UV) fluorescence of cartilage that occur after proteolytic digestion of cartilage. Bovine articular cartilage samples were incubated in varying concentrations of collagenase ranging from 10ug/mL up to 5mg/mL for 18 hours at 37°C, a model of OA. Pre- and post-incubation measurements were taken of the UV excitation-emission spectrum of each cartilage sample. Mechanical tests were performed to determine the pre- and post-digestion force/displacement ratio associated with indentation of each sample. Spectral changes in intrinsic cartilage fluorescence and stiffness of the cartilage were associated with proteolytic digestion. In particular, changes in the relative intensity of fluorescence peaks associated with pentosidine crosslinks (330 nm excitation, 390 nm emission) and tryptophan (290 nm excitation, 340 nm emission) were found to correlate with different degrees of cartilage digestion and cartilage stiffness. In principle, it may be possible to use UV fluorescence spectral data for early detection of damage to articular cartilage, and as a surrogate measure for cartilage stiffness.

  13. Symposium: evidence for the use of intra-articular cortisone or hyaluronic acid injection in the hip

    Science.gov (United States)

    Chandrasekaran, Sivashankar; Lodhia, Parth; Suarez-Ahedo, Carlos; Vemula, S. Pavan; Martin, Timothy J.; Domb, Benjamin G.

    2016-01-01

    The primary purpose of this review article is to discuss the role of diagnostic, corticosteroid, hyaluronic acid (HA) and platelet rich plasma (PRP) in the treatment of osteoarthritis (OA) and femoroacetabular impingement (FIA). These treatments play an important biological role in the non-operative management of these conditions. Two independent reviewers performed an search of PubMed for articles that contained at least one of the following search terms pertaining to intra-articular hip injection—local anaesthetic, diagnostic, ultrasound, fluoroscopic, image guided, corticosteroid, HA, PRP, OA, labral tears and FAI. Seventy-two full text articles were suitable for inclusion. There were 18 articles addressing the efficacy of diagnostic intra-articular hip injections. With respect to efficacy in OA there were 25 articles pertaining to efficacy of corticosteroid, 22 of HA and 4 of PRP. There were three articles addressing the efficacy of biologics in FAI. Diagnostic intra-articular hip injections are sensitive and specific for differentiating between intra-articular, extra-articular and spinal causes of hip symptoms. Ultrasound and fluoroscopy improves the precision of intra-articular positioning of diagnostic injections. Corticosteroids are more effective than HA and PRP in alleviating pain from hip OA. A higher dose of corticosteroids produces a longer benefit but volume of injection has no significant effect. Intra-articular corticosteroids do not increase infection rates of subsequent arthroplasty. There is currently limited evidence to warrant the routine use of therapeutic injections in the management of labral tears and FIA. PMID:27026814

  14. Symposium: evidence for the use of intra-articular cortisone or hyaluronic acid injection in the hip.

    Science.gov (United States)

    Chandrasekaran, Sivashankar; Lodhia, Parth; Suarez-Ahedo, Carlos; Vemula, S Pavan; Martin, Timothy J; Domb, Benjamin G

    2016-04-01

    The primary purpose of this review article is to discuss the role of diagnostic, corticosteroid, hyaluronic acid (HA) and platelet rich plasma (PRP) in the treatment of osteoarthritis (OA) and femoroacetabular impingement (FIA). These treatments play an important biological role in the non-operative management of these conditions. Two independent reviewers performed an search of PubMed for articles that contained at least one of the following search terms pertaining to intra-articular hip injection-local anaesthetic, diagnostic, ultrasound, fluoroscopic, image guided, corticosteroid, HA, PRP, OA, labral tears and FAI. Seventy-two full text articles were suitable for inclusion. There were 18 articles addressing the efficacy of diagnostic intra-articular hip injections. With respect to efficacy in OA there were 25 articles pertaining to efficacy of corticosteroid, 22 of HA and 4 of PRP. There were three articles addressing the efficacy of biologics in FAI. Diagnostic intra-articular hip injections are sensitive and specific for differentiating between intra-articular, extra-articular and spinal causes of hip symptoms. Ultrasound and fluoroscopy improves the precision of intra-articular positioning of diagnostic injections. Corticosteroids are more effective than HA and PRP in alleviating pain from hip OA. A higher dose of corticosteroids produces a longer benefit but volume of injection has no significant effect. Intra-articular corticosteroids do not increase infection rates of subsequent arthroplasty. There is currently limited evidence to warrant the routine use of therapeutic injections in the management of labral tears and FIA. PMID:27026814

  15. A biphasic finite element study on the role of the articular cartilage superficial zone in confined compression.

    Science.gov (United States)

    Guo, Hongqiang; Maher, Suzanne A; Torzilli, Peter A

    2015-01-01

    The aim of this study was to investigate the role of the superficial zone on the mechanical behavior of articular cartilage. Confined compression of articular cartilage was modeled using a biphasic finite element analysis to calculate the one-dimensional deformation of the extracellular matrix (ECM) and movement of the interstitial fluid through the ECM and articular surface. The articular cartilage was modeled as an inhomogeneous, nonlinear hyperelastic biphasic material with depth and strain-dependent material properties. Two loading conditions were simulated, one where the superficial zone was loaded with a porous platen (normal test) and the other where the deep zone was loaded with the porous platen (upside down test). Compressing the intact articular cartilage with 0.2 MPa stress reduced the surface permeability by 88%. Removing the superficial zone increased the rate of change for all mechanical parameters and decreased the fluid support ratio of the tissue, resulting in increased tissue deformation. Apparent permeability linearly increased after superficial removal in the normal test, yet it did not change in the upside down test. Orientation of the specimen affected the time-dependent biomechanical behavior of the articular cartilage, but not equilibrium behavior. The two tests with different specimen orientations resulted in very different apparent permeabilities, suggesting that in an experimental study which quantifies material properties of an inhomogeneous material, the specimen orientation should be stated along with the permeability result. The current study provides new insights into the role of the superficial zone on mechanical behavior of the articular cartilage. PMID:25465194

  16. Identification of stable normalization genes for quantitative real-time PCR in porcine articular cartilage

    Directory of Open Access Journals (Sweden)

    McCulloch Ryan S

    2012-11-01

    Full Text Available Abstract Background Expression levels for genes of interest must be normalized with an appropriate reference, or housekeeping gene, to make accurate comparisons of quantitative real-time PCR results. The purpose of this study was to identify the most stable housekeeping genes in porcine articular cartilage subjected to a mechanical injury from a panel of 10 candidate genes. Results Ten candidate housekeeping genes were evaluated in three different treatment groups of mechanically impacted porcine articular cartilage. The genes evaluated were: beta actin, beta-2-microglobulin, glyceraldehyde-3-phosphate dehydrogenase, hydroxymethylbilane synthase, hypoxanthine phosphoribosyl transferase, peptidylprolyl isomerase A (cyclophilin A, ribosomal protein L4, succinate dehydrogenase flavoprotein subunit A, TATA box binding protein, and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein—zeta polypeptide. The stability of the genes was measured using geNorm, BestKeeper, and NormFinder software. The four most stable genes measured via geNorm were (most to least stable succinate dehydrogenase flavoprotein, subunit A, peptidylprolyl isomerase A, glyceraldehyde-3-phosphate dehydrogenase, beta actin; the four most stable genes measured via BestKeeper were glyceraldehyde-3-phosphate dehydrogenase, peptidylprolyl isomerase A, beta actin, succinate dehydrogenase flavoprotein, subunit A; and the four most stable genes measured via NormFinder were peptidylprolyl isomerase A, succinate dehydrogenase flavoprotein, subunit A, glyceraldehyde-3-phosphate dehydrogenase, beta actin. Conclusions BestKeeper, geNorm, and NormFinder all generated similar results for the most stable genes in porcine articular cartilage. The use of these appropriate reference genes will facilitate accurate gene expression studies of porcine articular cartilage and suggest appropriate housekeeping genes for articular cartilage studies in other species.

  17. The determination of apoptosis rates on articular cartilages of ovariectomized rats with and without alendronate treatment.

    Science.gov (United States)

    Acar, Nuray; Balkarli, Huseyin; Soyuncu, Yetkin; Ozbey, Ozlem; Celik-Ozenci, Ciler; Korkusuz, Petek; Ustunel, Ismail

    2016-06-01

    Osteoporosis (OP) is a major health problem characterized by compromised bone strength. Osteoarthritis (OA) is a joint disease that progresses slowly and is characterized by breakdown of the cartilage matrix. Alendronate (ALN), a nitrogen-containing bisphosphonate (BIS), inhibits bone loss and increases bone mineralization, and has been used clinically for the treatment of OP. It is still controversial whether BIS is effective in inhibiting the progression of OA. Chondrocyte apoptosis has been described in both human and experimentally induced OA models. In our study we aimed to detect whether ALN could protect articular cartilage from degeneration and reduce apoptosis rates in experimentally OA induced rats. For this rats were ovariectomized (ovex), nine weeks after operation rats were injected 30 µg/kg/week ALN subcutaneously for six weeks. After six weeks articular cartilages were obtained. We did Safranin O staining and Mankin and Pritzker scorings to evaluate degeneration and investigated the expressions of p53, cleaved caspase 3, Poly ADP-ribose (PAR), Poly ADP-ribose polymerase 1 (PARP 1), and applied TUNEL technique to determine apoptotis rates. We found a significant decrease in glycosaminoglycan (GAG) amount and increased apoptosis which indicates damage on articular cartilages of ovex rats. GAG amount was higher and apoptosis rate was lower on articular cartilages of ALN treated ovex rats compared to the ovex group. In contrary to studies showing that early ALN treatment has a protective effect, our study shows late ALN treatment has a chondroprotective effect on articular cartilage since we treated rats nine weeks after ovariectomy. PMID:26631351

  18. Prevalence and characteristics of pneumatized articular tubercle: First large series in Iranian people

    International Nuclear Information System (INIS)

    This study was performed to determine the prevalence and characteristics of pneumatized articular tubercle or eminence among a defined group of Iranian people. Digital panoramic radiographs of 1694 patients in the Department of Oral and Maxillofacial Radiology, Hamadan Dental School, Iran were evaluated retrospectively to detect the above lesion. Finally, 1563 radiographs were selected according to inclusion criteria. Then, a review was done of 10 large case series found using a MEDLINE search of the literature. Chi-squared test was used to analyze the differences in variables such as age, gender, laterality, and locularity in our case series. The average age of our samples was 32.6±7.63 years. Pneumatized articular tubercle was found in 98 cases, representing a prevalence of 6.2% with a mean age of 22.8±7.9 and a range of 8 to 60 years. Sixty-four (65.3%) pneumatized articular tubercles were unilateral, with 30 lesions on the right and 34 on the left side. Bilateral lesions were found in 34 (34.7%) patients. 52 (53.06%) of the pneumatized articular tubercles were of the unilocular type and 46 (46.94%) were multilocular. The results showed no statistically significant differences regarding age (p=0.454), gender (p=0.634), laterality (p=0.252), or locularity (p=0.807) among the samples. Among ten large case series from other countries, the prevalence of pneumatized articular tubercle (6.2%) in Iranian patients was higher than that of all eight of the case series that used the same detection method as the present study of panoramic radiography.

  19. Effects of Chondroitinase ABC-Mediated Proteoglycan Digestion on Decellularization and Recellularization of Articular Cartilage.

    Directory of Open Access Journals (Sweden)

    Catherine A Bautista

    Full Text Available Articular cartilage has a limited capacity to heal itself and thus focal defects often result in the development of osteoarthritis. Current cartilage tissue engineering strategies seek to regenerate injured tissue by creating scaffolds that aim to mimic the unique structure and composition of native articular cartilage. Decellularization is a novel strategy that aims to preserve the bioactive factors and 3D biophysical environment of the native extracellular matrix while removing potentially immunogenic factors. The purpose of this study was to develop a procedure that can enable decellularization and recellularization of intact articular cartilage matrix. Full-thickness porcine articular cartilage plugs were decellularized with a series of freeze-thaw cycles and 0.1% (w/v sodium dodecyl sulfate detergent cycles. Chondroitinase ABC (ChABC was applied before the detergent cycles to digest glycosaminoglycans in order to enhance donor chondrocyte removal and seeded cell migration. Porcine synovium-derived mesenchymal stem cells were seeded onto the decellularized cartilage scaffolds and cultured for up to 28 days. The optimized decellularization protocol removed 94% of native DNA per sample wet weight, while collagen content and alignment were preserved. Glycosaminoglycan depletion prior to the detergent cycles increased removal of nuclear material. Seeded cells infiltrated up to 100 μm into the cartilage deep zone after 28 days in culture. ChABC treatment enhances decellularization of the relatively dense, impermeable articular cartilage by reducing glycosaminoglycan content. ChABC treatment did not appear to affect cell migration during recellularization under static, in vitro culture, highlighting the need for more dynamic seeding methods.

  20. Prevalence and characteristics of pneumatized articular tubercle: First large series in Iranian people

    Energy Technology Data Exchange (ETDEWEB)

    Shokri, Abbas; Noruzi-Gangachin, Marruf [Dept. of Oral and Maxillofacial Radiology, Dental School, Hamadan University of Medical Sciences, Hamadan (Iran, Islamic Republic of); Baharvand, Maryam; Mortazavi, Hamed [Dept. of Oral and Maxillofacial Medicine, Dental School, Shahid Beheshti University of Medical Sciences, Tehran (Iran, Islamic Republic of)

    2013-12-15

    This study was performed to determine the prevalence and characteristics of pneumatized articular tubercle or eminence among a defined group of Iranian people. Digital panoramic radiographs of 1694 patients in the Department of Oral and Maxillofacial Radiology, Hamadan Dental School, Iran were evaluated retrospectively to detect the above lesion. Finally, 1563 radiographs were selected according to inclusion criteria. Then, a review was done of 10 large case series found using a MEDLINE search of the literature. Chi-squared test was used to analyze the differences in variables such as age, gender, laterality, and locularity in our case series. The average age of our samples was 32.6±7.63 years. Pneumatized articular tubercle was found in 98 cases, representing a prevalence of 6.2% with a mean age of 22.8±7.9 and a range of 8 to 60 years. Sixty-four (65.3%) pneumatized articular tubercles were unilateral, with 30 lesions on the right and 34 on the left side. Bilateral lesions were found in 34 (34.7%) patients. 52 (53.06%) of the pneumatized articular tubercles were of the unilocular type and 46 (46.94%) were multilocular. The results showed no statistically significant differences regarding age (p=0.454), gender (p=0.634), laterality (p=0.252), or locularity (p=0.807) among the samples. Among ten large case series from other countries, the prevalence of pneumatized articular tubercle (6.2%) in Iranian patients was higher than that of all eight of the case series that used the same detection method as the present study of panoramic radiography.

  1. A STUDY OF FUNCTIONAL OUT COME OF INTRA - ARTICULAR CALCANEAL FRACTURES TREATED SURGICALLY

    Directory of Open Access Journals (Sweden)

    Prashanth

    2015-10-01

    Full Text Available The calcaneus (O scalcis is the largest and most often fractured tarsal bone. The treatment of calcaneal fractures continues to pose a challenge for the trauma surgeons despite advancement in surgical technique and implant devices. The prognosis for an extra - articular fra cture is uniformly good, but that for an intra - articular fracture is varied. The management of every aspect of intra - articular calcaneal fractures is controversial. Although some studies have demonstrated good results after open reduction and internal fixa tion of intra - articular calcaneal fractures, a few other studies say otherwise. The method of internal fixation is also a point of debate, with various proponents advocating fixation with pins, screws or plate fixation with screws. Even there is no consens us regarding the surgical approach, with many having been described, including medial, lateral, combined medial and lateral, extended lateral and sinus tarsi approaches. So it is the need of the hour, to identify treatment techniques, which use lesser hard ware, to provide better functional outcomes in terms of shorter duration of treatment, better stability and early weight bearing and so also the role of non - operative treatment in the calcaneal fracture management. In this study, we have attempted to evalu ate the results of calcaneal fracture management by open reduction and internal fixation. Ours is a prospective study centered in the Gandhi hospital from Nov 2012 to April 2014 in which 30 patients with intra - articular calcaneal fractures were treated by open reduction and internal fixation and the results were evaluated with AOFAS scoring system. In our analysis, we observed that an anatomical reduction to restore Bohler’s and Gissanes angles associated with rigid internal fixation is essential for better fu n ctional results.

  2. Low-intensity infrared laser effects on zymosan-induced articular inflammatory response

    Science.gov (United States)

    Januária dos Anjos, Lúcia Mara; da Fonseca, Adenilson d. S.; Gameiro, Jacy; de Paoli, Flávia

    2015-03-01

    Low-level therapy laser is a phototherapy treatment that involves the application of low power light in the red or infrared wavelengths in various diseases such as arthritis. In this work, we investigated whether low-intensity infrared laser therapy could cause death by caspase-6 apoptosis or DNA damage pathways in cartilage cells after zymosaninduced articular inflammatory process. Inflammatory process was induced in C57BL/6 mouse by intra-articular injection of zymosan into rear tibio-tarsal joints. Thirty animals were divided in five groups: (I) control, (II) laser, (III) zymosan-induced, (IV) zymosan-induced + laser and (V). Laser exposure was performed after zymosan administration with low-intensity infrared laser (830 nm), power 10 mW, fluence 3.0 J/cm2 at continuous mode emission, in five doses. Twenty-four hours after last irradiation, the animals were sacrificed and the right joints fixed and demineralized. Morphological analysis was observed by hematoxylin and eosin stain, pro-apoptotic (caspase-6) was analyzed by immunocytochemistry and DNA fragmentation was performed by TUNEL assay in articular cartilage cells. Inflammatory process was observed in connective tissue near to articular cartilage, in IV and V groups, indicating zymosan effect. This process was decreased in both groups after laser treatment and dexamethasone. Although groups III and IV presented higher caspase-6 and DNA fragmentation percentages, statistical differences were not observed when compared to groups I and II. Our results suggest that therapies based on low-intensity infrared lasers could reduce inflammatory process and could not cause death by caspase-6 apoptosis or DNA damage pathways in cartilage cells after zymosan-induced articular inflammatory process.

  3. Differences in articular-eminence inclination between medieval and contemporary human populations.

    Science.gov (United States)

    Kranjčić, Josip; Vojvodić, Denis; Žabarović, Domagoj; Vodanović, Marin; Komar, Daniel; Mehulić, Ketij

    2012-08-01

    The articular-eminence inclination is an important element in the biomechanics of the temporomandibular joint and the entire masticatory system; however, very little is known about this inclination in archaeological human populations. Therefore, the aim of this study was to determine the values of, in addition to the differences between, the articular-eminence inclination in medieval and contemporary human populations. The study was carried out on two dry skull groups. The first group consisted of 14 dry skulls from the medieval culture group Bijelo Brdo (BB) of East Croatia, and the other consisted of 137 recent dry skulls from the osteologic collection of the Institute of Anatomy (IA) in Zagreb. All BB skulls were dentulous, whereas the IA skulls were divided into dentulous and edentulous groups. The articular-eminence inclination was measured in relation to the Frankfurt horizontal plane on digital images of the skull's two lateral views using AutoCAD computer software. The mean value of the articular-eminence inclination in the BB sample group (49.57°) was lower, with a statistical significance (p<0.01), than those of the IA dentulous (61.56°), the IA edentulous (62.54°), and all the combined IA (61.99°) specimens. Because the values of the articular-eminence inclination can vary a lot with reference to the number of specimens and the different methods used for measuring, the obtained values yield only orientational information. Further investigations including a larger number of medieval specimens are needed to confirm the results obtained from this study. PMID:22721644

  4. Del Piero

    OpenAIRE

    Umbaca, Enzo

    2015-01-01

    Rifacendosi al “Pinturicchio”, epiteto con cui Gianni Agnelli consacrava il calciatore Alessandro Del Piero un “artista del calcio”, Enzo Umbaca scrisse al popolare personaggio invitandolo a collaborare ad una performance durante la quale Pinturicchio-Del Piero avrebbe affrescato il muro di una galleria torinese calciando un pallone macchiato di grafite contro un muro sul quale è appesa la copia di un opera del Pinturicchio.

  5. Secondary knee instability caused by fracture of the stabilizing insert in a dual-articular total knee

    DEFF Research Database (Denmark)

    Boesen, Morten P; Jensen, Tim Toftgaard; Husted, Henrik

    2004-01-01

    A case of a fractured polyethylene stabilizing insert causing secondary knee instability in a Dual-articular total knee arthroplasty (TKA) is presented. A 65-year-old woman who underwent surgery with a Dual-articular TKA 4 years earlier had a well-functioning prosthesis until a fall, after which...... she began complaining of an intermittent, audible clicking; pain; and instability. At surgery, a fractured polyethylene peg was discovered, and the tibial insert was replaced. At follow-up, she remains asymptomatic. This is the first description of a fractured stabilizing insert in a Dual......-articular knee....

  6. Uso de la magnetoterapia en afecciones articulares y periarticulares

    Directory of Open Access Journals (Sweden)

    ULISES SOSA SALINAS

    1996-06-01

    Full Text Available Se analizan los resultados obtenidos en 200 pacientes tratados en el Policlínico Integral Docente Centro, de Camagüey, con diversas artropatías y enfermedades ortopédicas y reumatológicas. Se utilizó el campo magnético producido por el equipo TERAMAG-MT-200. Se obtuvo buen resultado en 189 casos (94,5 %. Las afecciones más beneficiadas fueron las de la rodilla (osteoartritis, sinovitis, fibrosis y rigideces posquirúrgicas, condromalacia y enfermedad de Hoffa, la epicondilitis y otras lesiones del codo, la periartritis escapulohumeral, tendinitis, insercionitis, trocanteritis, síndrome de Barré-Liéou y los dedos en resorte. Se describen los métodos utilizados en cada afección.

  7. Hyperhomocysteinemia and methylenetetrahydrofolate reductase 677C→T and 1298A→C mutations in patients with inflammatory bowel disease Hiperhomocisteinemia y mutaciones de la metilentetrahidrofolato reductasa 677C→T y 1298A→C en pacientes con enfermedad inflamatoria intestinal

    Directory of Open Access Journals (Sweden)

    C. Fernández-Miranda

    2005-07-01

    Full Text Available Background: hyperhomocysteinemia has been recently described in patients with inflammatory bowel disease (IBD, that could be related to the increased risk for thrombosis that exists in this disease. The aim of this study was the assessment of hyperhomocysteinemia in patients with IBD and its relation among vitamin B12 and folate levels, and methylenetetrahydrofolate reductase (MTHFR 677C→ T and 1298A→C mutations. Patients and methods: fifty two consecutive patients with IBD were studied (29 women and 23 men; age: mean (standard deviation 41.7 [11.9] years and 186 controls with no difference in age and gender. Hyperhomocysteinemia was considered as homocysteine levels higher than mean plus two standard deviations of the control group (≥ 13 μmol/l. Results: patients had an elevated prevalence of hyperhomocysteinemia (17.3 vs. 3.7%; p = 0.002 and lower folate (7.6 [4.1] vs. 8.9 [3.7] ng/ml; p = 0.01 and B12 vitamin levels (499 [287] vs. 603 [231] pg/ml; p = 0.003. Homocysteinemia was higher (14.3 [5.8] vs. 9.1 [3.9] μmol/l; p = 0.006 in 6 patients (11.5% that had suffered thromboembolism. Frequency of MTHFR 677C→T (13.5 vs. 11.3%; p = 0.66 and 1298A→C (7.8 vs. 7.0%; p = 0.76 mutations was not increased in patients. Odds ratio (OR for IBD in hyperhomocysteinemic patient was 5.51, 95% confidence interval (CI, 1.81-16.76; p = 0.002. Hyperhomocysteinemia was negatively associated with feminine gender (OR 0.08, 95% CI 0.01-0.49; p = 0.006 and folate levels (OR 0.04, 95%CI: 0.007-0.20; p Fundamento: recientemente se ha descrito la existencia de hiperhomocisteinemia en la enfermedad inflamatoria intestinal (EII, que podría estar relacionada con el mayor riesgo de trombosis en esta enfermedad. El objetivo del estudio ha sido evaluar la hiperhomocisteinemia en los pacientes con EII y su relación con las concentraciones de vitamina B12 y folato séricos y con las mutaciones de la metilentetrahidrofolato reductasa (MTHFR 677C→T y 1298A

  8. Interferon beta-1a in chronic inflammatory demyelinating polyneuropathy: case report Interferon beta en polineuropatía crónica inflamatoria desmienlinizante: caso clínico

    Directory of Open Access Journals (Sweden)

    Andrés Maria Villa

    2004-09-01

    Full Text Available Chronic inflammatory demyelinating polyneuropathy (CIDP is an acquired immune-mediated neuropathy. It presents with a course of progression which may be slow and steady or step-wise or relapsing. Sensory ataxic polyneuropathy may be the only clinical manifestation of this disease. Treatment with interferon beta1a (INF beta1a has been tried with different results in patients who were refractory to other, more conventional, immunomodulatory therapies. Here we report on a patient who had a relapsing form of pure sensory ataxic CIDP and who failed to respond to intravenous human immunoglobulin. He was put on INF beta1a for 3 years. During this period he suffered no relapses while his condition stabilized.La polineuropatía crónica inflamatoria desmielinizante (PCID es una neuropatía inmuno-mediada, que presenta un curso clínico primariamente progresivo o en forma de recaídas. Las manifestaciones sensoriales pueden ser su unica forma de expresión clínica. El tratamiento con interferon beta 1a (IFN beta1a ha sido ensayado en varias oportunidades, con diferentes respuestas terapéuticas, en pacientes refractarios a las terapias inmunomoduladoras convencionales. Nosotros comunicamos un paciente con una forma ataxica recurrente de PCID, que no respondió al tratamiento con inmunoglobulina endovenosa. Posteriormente fue tratado con IFN beta 1 a por tres años. Durante el período de seguimiento no mostró nuevas recaídas y su cuadro neurológico se estabilizó.

  9. La recuperación de la palabra. Perspectivas hermenéuticas sobre la cuestión del lenguaje

    OpenAIRE

    Revilla, Carmen

    1997-01-01

    El planteamiento hermenéutico del tema del lenguaje, en su versión gadameriana, constituye una importante aportación al diálogo con las distintas posiciones en las que el pensamiento de nuestro siglo se hace eco de un problema: la incapacidad del lenguaje para articular la experiencia del mundo, en orden a posibilitar el ejercicio de la racionalidad práctica. La pretensión de estas páginas es presentar el sesgo desde el que esta intervención adquiere un especial protagonismo en la fi...

  10. Jürgen Habermas, democracia, inclusión del otro y patriotismo constitucional desde la ética del discurso

    Directory of Open Access Journals (Sweden)

    Jorge Araya Anabalón

    2011-07-01

    Full Text Available El presente trabajo sobre la ética del discurso de Jurgen Habermas, da cuentade las connotaciones y exigencias para una democracia con legitimidad políticay moral en nuestra sociedad. Entendiendo que una democracia radicalno es algo dado por una sola vez y para siempre, sino el resultado de unproceso comunicativo que permite articular intereses distintos, donde estánen juego la identidad, la solidaridad, la inclusión del “otro” y el patriotismoconstitucional, entre otras cosas. Es decir, se puede corregir y recuperar elideario normativo de la democracia moderna reduciendo la hegemonía de laracionalidad instrumental.

  11. CLINICAL OUTCOME OF INTRA - ARTICULAR DISTAL RADIUS FRACTURES TREATED WITH PLATE AND SCREWS

    Directory of Open Access Journals (Sweden)

    Girish

    2015-02-01

    Full Text Available BACKGROUND : Incidence of fractures of distal radius are increasing due to more geriatric population and road traffic accidents. The fundamental goal of distal radius fractures treatment is restoration of normal or near normal alignment and articular congruity. Restoration of the anatomy and articular surface may prevent the onset of arthritis and improve function. AIMS: To determine clinical outcome of intra - articular distal radius fractures treated with plate and screws. METHOD: 20 patients of intra - articular distal radius fracture treated with open reduction and internal fixation with plate and screws between November 2012 and October 2014 were evaluated. Clinical and radiological evaluation was done at 3 weeks, 3 months, 6 months and one year after surgery. Fractures were cla ssified according to Melone fracture classification. There were 8 type - 2 fractures, 5 type - 3 fractures,4 type - 4 fractures, 2 type - 5 and 1 type - 1 fracture. There were 19 (95% males and 1 (5% females. Age range was between 24 to 50 years with average of 34 years. Fracture was stabilized with the plate and screws at an average of 5 to 7 days post trauma. RESULTS: All fractures had sound clinical and radiological union with an average radiological union time of 14 weeks (range between 2.5 – 6 months. Average palmar flexion of wrist was 56deg, dorsi - flexion was 59deg, radial deviation was17deg, ulnar deviation was 23deg, pronation was 65deg and supination was 72degrees. Gartland and Werley system was used to evaluate the function, 80% of patients had excellent to good results out of which 20% were excellent and 60% were good results, and 15% had fair results and poor results were found in 5%. Average radial inclination was 21 degrees and palmar tilt was 9.5 degrees . CONCLUSION: Open reduction and internal fixation with plate and screws is an excellent, and effective technique in management of intra - articular distal radius fractures in terms of high union

  12. INTERNAL FIXATION OF INTRA ARTICULAR CALCANEUM FRACTURES USING LOCKING COMPRESSION PLATE

    Directory of Open Access Journals (Sweden)

    Neelakrishnan

    2014-10-01

    Full Text Available INTRODUCTION: Calcaneum is the most frequently fractured tarsal bone. Historically intra articular calcaneum fractures treated non-operatively which led to increased morbidity due to in congruency of articular surface resulting in subtalar arthritis. With advent of CT scan, better implants and improved methods of fixation. Operative treatment has now become a standard method. AIM OF THE STUDY: To study the functional and radiological outcome of intra articular calcaneum fractures treated by open reduction and internal fixation using locking compression plate. MATERIALS AND METHODS: Fifteen patients with intra articular calcaneum fractures treated by open reduction and internal fixation using locking compression plate from May 2012 to September 2014 at Rajah Muthiah Medical College Hospital with follow up of 6months. The fractures were classified on the basis of computer tomography (CT findings as Sanders type I to IV. The aim of our treatment is to achieve anatomical reconstruction of all articular surfaces, restore Bohler’s and Gissane angles, to carry out primary stable fixation and begin early mobilization. The patients were evaluated by Modified Maryland Foot Score, with excellent defined as90 - 100 points, good as 75 – 89 points, fair as 50 – 74 points and poor as <50 points. RESULTS: Fourteen patients were male and only one female. Twelve patients sustained fractures due to fall from height, three patients due to RTA. The mean pre-operative Bohler’s angle was 13 degree and mean post-operative angle was 26.2degree. The mean pre-operative Gissane angle was 147.6 degree and the mean post-operative angle was 121 degree. Excellent modified Maryland Foot score were achieved in 9 patients, good in 3, fair in 1patient.Only 2 had poor outcome. CONCLUSION: Surgical treatment of intra-articular calcaneum fractures using locking compression plate by lateral approach has good functional outcome. CT scan is required for understanding the

  13. Quantitative MRI Evaluation of Articular Cartilage Using T2 Mapping Following Hip Arthroscopy for Femoroacetabular Impingement

    Science.gov (United States)

    Mayer, Stephanie W.; Wagner, Naomi; Fields, Kara G.; Wentzel, Catherine; Burge, Alissa; Potter, Hollis G.; Lyman, Stephen; Kelly, Bryan T.

    2016-01-01

    Objectives: Cam-type femoroacetabular impingement (FAI) causes a shearing and delamination injury to the acetabular articular cartilage due to a mismatch between the size of the femoral head and the acetabulum. This mechanism is thought to lead to early osteoarthritis in this population. Cam decompression has been advocated to eliminate impingement, with the ultimate goal of halting the progression of articular cartilage delamination. Although outcomes following this procedure in the young adult population have been favorable at short and medium term follow up, it is not known whether the articular cartilage itself is protected from further injury by changing the biomechanics of the joint with decompression of the cam morphology. The purpose of this study is to compare the pre- and post-operative integrity of the acetabular articular cartilage using T2 mapping to determine if hip arthroscopy is protective of the articular cartilage at short- to medium term follow up. Methods: Males between 18 and 35 years of age who had pre-operative T2 mapping MRIs, underwent hip arthroscopy for cam or mixed-type FAI with an alpha angle greater than 50°, and had at least 2 year follow-up were identified. Post-operative MRIs were performed and T2 relaxation times in the transition zone and weight bearing articular cartilage in the anterosuperior acetabulum at deep and superficial chondral layers were recorded at nine points on three sagittal sequences on pre and post-operative MRIs. A paired t-test was used to compare T2 relaxation values between pre-operative and post-operative scans. Results: Eleven hips were evaluated. Mean age was 26.3 years (range 21 - 35). Mean follow up time to post-operative T2 mapping MRI was 2.6 years (range 2.4 - 2.7). The change in T2 relaxation time was not significantly different between pre- and post-operative MRI scans for any of the nine regions in the deep zone of the acetabular cartilage (p=0.065 - 0.969) or the superficial zone of the

  14. Clinical utility of ultrasound guidance for intra-articular knee injections: a review

    Directory of Open Access Journals (Sweden)

    Berkoff DJ

    2012-03-01

    Full Text Available David J Berkoff1, Larry E Miller2,3, Jon E Block31Department of Orthopedics, University of North Carolina School of Medicine, Chapel Hill, NC; 2Miller Scientific Consulting Inc, Arden, NC; 3The Jon Block Group, San Francisco, CA, USAAbstract: Intra-articular corticosteroid and hyaluronic acid injections provide short-term symptom amelioration for arthritic conditions involving structural damage or degenerative changes in the knee. Conventional palpation-guided anatomical injections frequently result in inaccurate needle placement into extra-articular tissue and adjacent structures. The purpose of this review was to determine the effect of ultrasound guidance on the accuracy of needle placement, clinical outcomes, and cost-effectiveness in comparison with anatomical landmark-guided intra-articular large joint injections, with particular emphasis on the knee. A total of 13 relevant studies were identified; five studied the knee, seven studied the shoulder, one used both the knee and shoulder, and none studied the hip. Ultrasound was used in seven studies; the remaining studies utilized air arthrography, fluoroscopy, magnetic resonance arthrography, or magnetic resonance imaging. Across all studies (using all imaging modalities and all joints, needle placement accuracy ranged from 63% to 100% with ultrasound and from 39% to 100% with conventional anatomical guidance. Imaging guidance improved the accuracy of intra-articular injections of the knee (96.7% versus 81.0%, P < 0.001 and shoulder (97.3% versus 65.4%, P < 0.001. In particular, ultrasound guidance of knee injections resulted in better accuracy than anatomical guidance (95.8% versus 77.8%, P < 0.001, yielding an odds ratio of 6.4 (95% confidence interval 2.9–14. Ultrasound guidance notably improves injection accuracy in the target intra-articular joint space of large joints including the knee. The enhanced injection accuracy achieved with ultrasound needle guidance directly improves

  15. Intra-articular Enzyme Replacement Therapy with rhIDUA is Safe, Well-Tolerated, and Reduces Articular GAG Storage in the Canine Model of Mucopolysaccharidosis Type I

    Science.gov (United States)

    Wang, Raymond Y; Aminian, Afshin; McEntee, Michael F; Kan, Shih-Hsin; Simonaro, Calogera M; Lamanna, William; Lawrence, Roger; Ellinwood, N. Matthew; Guerra, Catalina; Le, Steven Q; Dickson, Patricia I; Esko, Jeffrey D

    2014-01-01

    Background Treatment with intravenous enzyme replacement therapy and hematopoietic stem cell transplantation for mucopolysaccharidosis (MPS) type I does not address joint disease, resulting in persistent orthopedic complications and impaired quality of life. A proof-of-concept study was conducted to determine the safety, tolerability, and efficacy of intra-articular recombinant human iduronidase (IA-rhIDUA) enzyme replacement therapy in the canine MPS I model. Methods Four MPS I dogs underwent monthly rhIDUA injections (0.58 mg/joint) into the right elbow and knee for six months. Contralateral elbows and knees concurrently received normal saline. No intravenous rhIDUA therapy was administered. Monthly blood counts, chemistries, anti-rhIDUA antibody titers, and synovial fluid cell counts were measured. Lysosomal storage of synoviocytes and chondrocytes, synovial macrophages and plasma cells were scored at baseline and one month following the final injection. Results All injections were well-tolerated without adverse reactions. One animal required prednisone for spinal cord compression. There were no clinically significant abnormalities in blood counts or chemistries. Circulating anti-rhIDUA antibody titers gradually increased in all dogs except the prednisone-treated dog; plasma cells, which were absent in all baseline synovial specimens, were predominantly found in synovium of rhIDUA-treated joints at study-end. Lysosomal storage in synoviocytes and chondrocytes following 6 months of IA-rhIDUA demonstrated significant reduction compared to tissues at baseline, and saline-treated tissues at study-end. Mean joint synovial GAG levels in IA-rhIDUA joints was 8.62±5.86 μg/mg dry weight and 21.6±10.4 μg/mg dry weight in control joints (60% reduction). Cartilage heparan sulfate was also reduced in the IA-rhIDUA joints (113±39.5 ng/g wet weight) compared to saline-treated joints (142±56.4 ng/g wet weight). Synovial macrophage infiltration, which was present in all

  16. Evaluation using MRI T2 mapping of the articular cartilage after anterior cruciate ligament injury in young athletes

    International Nuclear Information System (INIS)

    Articular cartilage damage coexisting in the anterior cruciate ligament (ACL) injury in young athletes is not rare. We evaluated the conditions of the articular cartilage using MRI T2 mapping method and compared the vesults with the findings of arthroscopy. From June to August in 2010, we performed ACL reconstruction in 31 patients. We selected 17 cases (eleven men and six women, mean age 19.1 years old), all of whom were athletes and the under 29 years old. Articular cartilage damage was observed in six out of 10 cases, and their T2 values were high on MRI T2 mapping. On the other hand, damage was observed only in one out of seven cases, and T2 values were in the normal level of the mapping. Using MRI T2 mapping, we can evaluate the articular cartilage at an early phase noninvasively. MRI T2 mapping is useful and effective for athletes. (author)

  17. Artritis psoriásica: Contribuciones al conocimiento de su patogenia, de sus comorbilidades y al perfil de seguridad de su tratamiento

    OpenAIRE

    Busquets Pérez, Noemí

    2014-01-01

    La artritis psoriásica (AP) es una enfermedad articular inflamatoria crónica, seronegativa, asociada a psoriasis. Esta tesis está compuesta por tres artículos publicados en revistas indexadas, sobre diferentes aspectos de la AP. El primer artículo presentado tuvo como objetivo evaluar la prevalencia de psoriasis moderada-grave (P-MG) en pacientes con AP y las relaciones entre la P-MG y otras variables relacionadas con la artritis. La prevalencia de P-MG en la cohorte fue del 31.3% (52 p...

  18. DIAGNÓSTICO Y PROPUESTA PARA UNA GESTIÓN INTEGRAL DEL RIESGO EN EL VALLE DE ABURRA: RED RIESGOS

    OpenAIRE

    ARISTIZÁBAL EDIER; VARGAS RICHARD

    2010-01-01

    A partir del análisis de la situación organizacional de las diferentes instituciones en el Valle de Aburrá frente a la reducción de desastres y emergencias asociadas con los fenómenos de origen natural y antrópico, el Área Metropolitana del Valle de Aburrá, como autoridad ambiental y entidad planificadora, hace una propuesta que pretende articular todas las entidades, organizaciones e instituciones públicas y privadas hacia una gestión integral del riesgo, y la cual denominó: Red para la Gest...

  19. In-vitro intra-articular pressure distribution in the ankle: can it be used for model validation?

    OpenAIRE

    Natsakis, Tassos; Burg, Fien; Dereymaeker, Greta; Jonkers, Ilse; Vander Sloten, Jos

    2014-01-01

    Background Several modelling attempts to predict intra-articular pressure distribution in the ankle joint have been made. Input kinematics for such models can be measured with a variety of techiniques, for validating with intra-articular pressure though, we are limited to in-vitro experimentation. The aim of this study was to investigate the influence of the insertion of a pressure sensor on joint kinematics during in-vitro gait simulations. Methods 10 freshly frozen human cadaveric ...

  20. Topographic Analysis of the Glenoid and Proximal Medial Tibial Articular Surfaces - A Search for the Ideal Match for Glenoid Resurfacing

    OpenAIRE

    Gupta, Anil K.; Forsythe, Brian; Andrew S. Lee; Harris, Joshua D.; McCormick, Francis; Abrams, Geoff D.; Verma, Nikhil N; Inoue, Nozomu; Cole, Brian J.

    2013-01-01

    Objectives: Current knowledge of the appropriate site of osteochondral allograft harvest to match glenoid morphology for the purposes of glenoid resurfacing is lacking. This has led to difficulty with adequately restoring the geometry of the glenoid using current available techniques. The purpose of this study was to quantify the articular surface topography of the glenoid and medial tibial plateau via 3-dimensional (3D) modeling to determine if the medial tibial articular surface provides an...

  1. Alternative technique of cervical spinal stabilization employing lateral mass plate and screw and intra-articular spacer fixation

    OpenAIRE

    Atul Goel

    2013-01-01

    Aim: The author discusses an alternative technique of segmental cervical spinal fixation. Material and Methods: The subtleties of the technique are discussed on the basis of experience with 3 cases with a follow-up of between 30 and 36 months. Technique: The technique involves debridement of facetal articular cartilage, distraction of facets, jamming of ′Goel spacer′ into the articular cavity and fortification of the fixation by lateral mass plate and screw fixation. The ′double-insurance′ me...

  2. A Validated Model of the Pro- and Anti-Inflammatory Cytokine Balancing Act in Articular Cartilage Lesion Formation

    OpenAIRE

    Wang, Xiayi; Brouillette, Marc J.; Ayati, Bruce P; Martin, James A.

    2015-01-01

    Traumatic injuries of articular cartilage result in the formation of a cartilage lesion and contribute to cartilage degeneration and the risk of osteoarthritis (OA). A better understanding of the framework for the formation of a cartilage lesion formation would be helpful in therapy development. Toward this end, we present an age and space-structured model of articular cartilage lesion formation after a single blunt impact. This model modifies the reaction-diffusion-delay models in Graham et ...

  3. Experience of emplying extracorporal shock-wave therapy for treating limb enthesopathies in patients with articular hypermobility syndrome

    OpenAIRE

    VOROTNIKOV ALEXANDER; SANEYEVA GALINA; TSYMBAL ANDREY

    2014-01-01

    Purpose: to study the efficiency of extracorporal shock-wave therapy and the affected area orthopedic relief for treating pain syndrome associated with enthesopathies in patients with articular hypermobility syndrome.75 patients with enthesopathies of various localizations and diagnosed articular hypermobility were observed in 2008-2011, their age varying from 35 to 55 years (median age: 37.5±0.4 years). The treatment mode was out-patient, with a shockwave device PIEZOSON-100 (manufacturer: R...

  4. Activated platelet-rich plasma improves adipose-derived stem cell transplantation efficiency in injured articular cartilage

    OpenAIRE

    Pham, Phuc Van; Bui, Khanh Hong-Thien; Ngo, Dat Quoc; Vu, Ngoc Bich; Truong, Nhung Hai; Phan, Nhan Lu-Chinh; Le, Dung Minh; Duong, Triet Dinh; Nguyen, Thanh Duc; Le, Vien Tuong; Phan, Ngoc Kim

    2013-01-01

    Introduction Adipose-derived stem cells (ADSCs) have been isolated, expanded, and applied in the treatment of many diseases. ADSCs have also been used to treat injured articular cartilage. However, there is controversy regarding the treatment efficiency. We considered that ADSC transplantation with activated platelet-rich plasma (PRP) may improve injured articular cartilage compared with that of ADSC transplantation alone. In this study, we determined the role of PRP in ADSC transplantation t...

  5. Caracterización de la disfunción vascular sanguínea y linfática en la cirrosis hepática: Evaluación de la inhibición del factor de crecimiento placentarioy del óxido nítrico como estrategias terapéuticas

    OpenAIRE

    Ribera Sabaté, Jordi

    2012-01-01

    El hígado cirrótico experimenta a lo largo de todo el desarrollo de la enfermedad una serie de cambios estructurales, debidos a la acumulación de matriz extracelular y a la inflamación crónica, que vuelven al tejido hipóxico. La hipoxia tisular provoca la liberación de agentes proangiogénicos, como VEGF-A, que aumentan la irrigación del tejido para compensar la falta de oxígeno. Además, muchas citoquinas sintetizadas por las células inflamatorias o por las células hepáticas estrelladas activa...

  6. Effects of low-intensity pulsed ultrasound in repairing injured articular cartilage

    Institute of Scientific and Technical Information of China (English)

    JIA Xiao-lin; CHEN Wen-zhi; ZHOU Kun; WANG Zhi-biao

    2005-01-01

    Objective: To investigate the effects of low-intensity pulsed ultrasound in repairing injured articular cartilage. Methods: Ten adult New Zealand rabbits with bilateral full-thickness osteochondral defects on the cartilage surface of intercondylar fossas were used in this study. The wounds in the left knees were treated with low-intensity pulsed ultrasound as the experimental group. The right knees received no treatment as the control group. All the animals were killed at 8 weeks after injury and the tissues in the wounds were collected for gross appearance grading, histological grading and proteoglycan quantity. Results: The scores of the gross appearance grades, histological grades and the optical density of toluidine blue of the tissues in the experimental group were significantly higher than those of the controls at 8 weeks after injury (P<0.05). Conclusions: Low-intensity pulsed ultrasound can accelerate the repair of injured articular cartilage.

  7. Inferomedial or Inferolateral Intra-articular Injections of the Knee to Minimize Pain Intensity.

    Science.gov (United States)

    Pierce, Todd P; Elmallah, Randa K; Jauregui, Julio J; Cherian, Jeffrey J; Harwin, Steven F; Mont, Michael A

    2016-05-01

    Pain levels of 3 knee intra-articular corticosteroid injection sites were assessed to determine if an optimal site exists. Patients were stratified by site, demographic, and disease characteristics. All injections were performed by 1 surgeon using a uniform technique. Pain severity was assessed before, 1 minute after, and 5 minutes after injection using a visual analog scale. Mean visual analog scale scores for the lateral suprapatellar, medial infrapatellar, and lateral infrapatellar injection sites were 7, 4, and 2 points, respectively, but this was not statistically significant. These results suggest intra-articular injections should be administered from an inferomedial or inferolateral site to minimize pain intensity. [Orthopedics. 2016; 39(3):e578-e581.]. PMID:27064778

  8. Intra-articular therapy with tumor necrosis factor-α antagonists: an update

    Directory of Open Access Journals (Sweden)

    S. Bello

    2014-03-01

    Full Text Available The aim of the study was to review from the present literature the intra-articular (IA use of the TNF-blocking drugs. A total of 28 papers about this topic were found through a search in PubMed; the first publication’s date was July 2003. These studies include a total of 214 patients affected by 12 different joint diseases that reported a total of 1046 intra-articular therapies carried out in 10 different joint sites. Infliximab and etanercept were the most widely used medications. The safety of this treatment clearly emerges from our analysis, while more difficult was the evaluation of its efficacy. Nevertheless we deduced an ideal patient profile that may better respond to the IA anti-TNF treatment.

  9. Ángulo óptimo articular y ejercicio: bases y aplicaciones

    OpenAIRE

    Pablo Antonio Rubio-Sobrino; Raúl Rodríguez-Casares; Xavier Aguado; Alegre, Luis M.

    2012-01-01

    El ángulo óptimo se refiere a la posición articular en la que se produce el pico máximo de momento de fuerza, dentro de la curva ángulo-momento articular. Este parámetro puede utilizarse para estimar las modificaciones en la curva fuerza-longitud de un grupo muscular. El ángulo óptimo puede ser obtenido a partir de medidas en tests isométricos o dinámicos, y esto debe ser tenido en cuenta a la hora de establecer comparaciones. El ángulo óptimo puede ser modificado tanto de forma aguda como cr...

  10. The influence of sterilization method on articular surface damage of retrieved cruciate-retaining tibial inserts.

    Science.gov (United States)

    Greulich, Matthew T; Roy, Marcel E; Whiteside, Leo A

    2012-06-01

    This observational study was designed to determine the importance of sterilization method and insert thickness as predictors of articular damage of cruciate-retaining polyethylene components used in total knee arthroplasty. Ninety-nine explanted tibial inserts were evaluated for surface damage. Severe damage modes were observed in 36 of 52 of γ-irradiated inserts but none of those sterilized by ethylene oxide. Articular damage significantly correlated to time in vivo but not to insert thickness. Inserts sterilized by ethylene oxide gas in gas-permeable packaging exhibited a significantly lower damage accumulation rate compared with inserts sterilized by γ radiation and stored in air or an inert environment. γ irradiation and storage in argon instead of air reduced the frequency of severe damage such as delamination but not the overall damage rate. PMID:22177798

  11. Andrographolide Enhances Proliferation and Prevents Dedifferentiation of Rabbit Articular Chondrocytes: An In Vitro Study

    Directory of Open Access Journals (Sweden)

    Li-ke Luo

    2015-01-01

    Full Text Available As the main active constituent of Andrographis paniculata that was applied in treatment of many diseases including inflammation in ancient China, andrographolide (ANDRO was found to facilitate reduction of edema and analgesia in arthritis. This suggested that ANDRO may be promising anti-inflammatory agent to relieve destruction and degeneration of cartilage after inflammation. In this study, the effect of ANDRO on rabbit articular chondrocytes in vitro was investigated. Results showed that not more than 8 μM ANDRO did no harm to chondrocytes (P0.05. The viability assay, hematoxylin-eosin, safranin O, and immunohistochemical staining also showed better performances in ANDRO groups. As to the doses, 3 μM ANDRO showed the best performance. The results indicate that ANDRO can accelerate proliferation of rabbit articular chondrocytes in vitro and meanwhile maintain the phenotype, which may provide valuable references for further exploration on arthritis.

  12. Osseous scintigraphy in exploration of fever osteo-articular pain in sickle cell disease

    International Nuclear Information System (INIS)

    Osteo articular complications of sickle cell disease are multiple and can occur in the acute mode, (Bone infarction, acute osteomyelitis) or chronic (osteonecrosis, osteomyelitis).Through 6 cases we present the interest, lack and limitations of planar scintigraphy with bis phosphonates. Two patients underwent an early bone scan supplemented by medullary scintigraphy with nano colloids, the diagnosis was a bone infarction. In two children, the bone scan was performed between 5 and 7 days after the beginning of symptoms and did not objectify image of acute osteo articular complication. In the last patient, abnormal scintigraphy does not allow to differentiate osteomyelitis and bone infarction. The bone scan remains an essential consideration in the exploration of bone manifestations in sickle cell disease. Its association with bone marrow scintigraphy provides better diagnostic accuracy in differentiating osteomyelitis and bone infarction and adjusting the therapeutic management. (N.C.)

  13. Response of first attack of inflammatory bowel disease requiring hospital admission to steroid therapy Respuesta al tratamiento esteroideo del primer brote de enfermedad inflamatoria intestinal que requiere ingreso hospitalario

    OpenAIRE

    M. Abu-Suboh Abadía; F. Casellas; Vilaseca, J; J-R. Malagelada

    2004-01-01

    Introduction: corticoid administration is the usual treatment of Crohn' disease (CD) and ulcerative colitis (UC) attacks. How-ever, information available on response rates and their predictive factors is scarce. Objective: to establish response to steroidal treatment in an homogeneous group of patients with CD or UC during their first admission to hospital. Methods: restrospective analysis of 86 patients who received systemic steroidal treatment for a severe flare-up during their first hospit...

  14. Fragmento N-terminal del propéptido natriurético tipo B (NT-proBNP), respuesta inflamatoria y estrés oxidativo en la hipertensión esencial

    OpenAIRE

    Roselló Lletí, Esther

    2011-01-01

    El sistema circulatorio humano es una intrincada red de mecanismos destinados a mantener la homeostasis de presión y flujo pese a las diferentes perturbaciones que sufre y por tanto, una elevación de la presión arterial puede provocar un trastorno en las relaciones de los factores que mantienen este equilibrio. La hipertensión esencial, es el resultado de una compleja interacción entre cambios genéticos, neurohormonales, inflamatorios y bioquímicos. Como consecuencia el paciente hipertenso ti...

  15. Repair of articular cartilage defects in minipigs by microfracture surgery and BMSCs transplantation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Objective: To investigate the feasibility of minimal invasive repair of cartilage defect by arthroscope-aided microfracture surgery and autologous transplantation of mesenchymal stem cells. Methods: Bone marrow of minipigs was taken out and the bone marrow derived mesenchymal stem cells (BMSCs) were isolated and cultured to passage 3. Then 6 minipigs were randomly divided into 2 groups with 6 knees in each group. After the articular cartilage defect was induced in each knee. the left defect received microfracture surgery and was injected with 2. 5 ml BMSCs cells at a concentration of 3×107 cells/ml into the articular cavity; while right knee got single microfracture or served as blank control group. The animals were killed at 8 or 16 weeks, and the repair tissue was histologically and immunohistochemically examined for the presence of type Ⅱ collagen and glycosaminoglycans (GAGs) at 8 and 16 weeks. Results:Eight weeks after the surgery, the overlying articular surface of the cartilage defect showed normal color and integrated to adjacent cartilage. And 16 weeks after surgery, hyaline cartilage was observed at the repairing tissues and immunostaining indicated the diffuse presence of this type Ⅱ collagen and GAGs throughout the repair cartilage in the treated defects. Single microfracture group had the repairing of fibro-cartilage, while during the treatment, the defects of blank group were covered with fewer fiber tissues, and no blood capillary growth or any immunological rejection was observed. Conclusion:Microfracture technique and BMSCs transplantation to repair cartilage defect is characterized with minimal invasion and easy operation, and it will greatly promote the regeneration repair of articular cartilage defect.

  16. Pathological change of articular cartilage in the mandibular head treated with immunosuppressant FK 506

    OpenAIRE

    Ueno, T; Kagawa, T; Kanou, M.; Fujii, T.; Fukunaga, J.; Mizukawa, N.; Sugahara, T.; Yamamoto, T.

    2004-01-01

    While several reports have documented immunosuppressant-induced osteoporosis, the exact mechanism of the pathological change of the joint remains to be clarified. In the present study, we have demonstrated the pathological change of the articular cartilage in the mandibular head of five Sprague-Dawley rats administered with the immunosuppressant FK 506 for 28 days. Three-dimensional micro-computed tomography of the mandibular heads in treated rats showed a ...

  17. The study on the mechanical characteristics of articular cartilage in simulated microgravity

    Institute of Scientific and Technical Information of China (English)

    Hai-Jun Niu; Qing Wang; Yue-Xiang Wang; Ang Li; Lian-Wen Sun; Yan Yan; Fan Fan; De-Yu Li; Yu-Bo Fan

    2012-01-01

    The microgravity environment of a long-term space flight may induce acute changes in an astronaut's musculo-skeletal systems.This study explores the effects of simulated microgravity on the mechanical characteristics of articular cartilage.Six rats underwent tail suspension for 14 days and six additional rats were kept under normal earth gravity as controls.Swelling strains were measured using high-frequency ultrasound in all cartilage samples subject to osmotic loading.Site-specific swelling strain data were used in a triphasic theoretical model of cartilage swelling to determine the uniaxial modulus of the cartilage solid matrix.No severe surface irregularities were found in the cartilage samples obtained from the control or tail-suspended groups.For the tail-suspended group,the thickness of the cartilage at a specified site,as determined by ultrasound echo,showed a minor decrease.The uniaxial modulus of articular cartilage at the specified site decreased significantly,from (6.31 ± 3.37) MPa to (5.05 ± 2.98) MPa (p < 0.05).The histology-stained image of a cartilage sample also showed a reduced number of chondrocytes and decreased degree of matrix staining.These results demonstrated that the 14 d simulated microgravity induced significant effects on the mechanical characteristics of articular cartilage.This study is the first attempt to explore the effects of simulated microgravity on the mechanical characteristics of articular cartilage using an osmotic loading method and a triphasic model.The conclusions may provide reference information for manned space flights and a better understanding of the effects of microgravity on the skeletal system.

  18. Derepression of miRNA-138 contributes to loss of the human articular chondrocyte phenotype

    OpenAIRE

    Seidl, C; Martinez-Sanchez, A; Murphy, CL

    2016-01-01

    Objective: To investigate the function of microRNA-138 (miR-138) in human articular chondrocytes (HACs). Methods: The expression of miR-138 in intact cartilage and cultured chondrocytes and the effects of miR-138 overexpression on chondrocyte marker genes were investigated. Targets of miR-138 relevant to chondrocytes were identified and verified by overexpression of synthetic miRNA mimics and inhibitors, luciferase assays, chromatin immunoprecipitation, and RNA immunoprecipitation o...

  19. Fluid collections and juxta-articular cystic lesions of the shoulder: spectrum of MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Mellado, J.M.; Salvado, E.; Camins, A.; Ramos, A.; Sauri, A. [Institut de Diagnostic per la Imatge, Hospital Joan XXIII, Tarragona (Spain); Merino, X. [Institut de Diagnostic per la Imatge, Hospital Vall' Ebron, Barcelona (Spain); Calmet, J. [Orthopaedic Surgery, Hospital Joan XXIII, Carrer Doctor Mallafre Guasch, Tarragona (Spain)

    2002-03-01

    The MR imaging features of fluid collections and juxta-articular cystic lesions of the shoulder are discussed, with special focus on those related to subacromial impingement and rotator cuff tears. Other more unusual fluid collections and cystic lesions are described, including rice-bodies bursitis, idiopathic synovial osteochondromatosis, dialysis-related amyloid arthropathy, hemophilic arthropathy, infectious conditions, non-infectious inflammatory arthritis, and paralabral cysts. (orig.)

  20. Asymmetry of the articular eminence in dentate and partially edentulous populations.

    Science.gov (United States)

    Jasinevicius, T R; Pyle, M A; Lalumandier, J A; Nelson, S; Kohrs, K J; Türp, J C; Sawyer, D R

    2006-04-01

    The purpose of this study was to assess the degree of right-left asymmetry of the glenoid fossa. The specific aims were (1) to determine whether there were relationships between age, number of teeth, slope of the articular eminence, fossa depth, and the degree of right-left asymmetry, and (2) to compare the right-left asymmetry of two populations, one characterized by an acceptable occlusion (A-Occ), the other by an unacceptable occlusion (partially edentulous; Un-Occ). A-Occ was defined as possessing a minimum of 28 teeth that would allow for hand articulation of the mandibular teeth to the maxillary teeth. Un-Occ had fewer than 17 teeth, which would make it impossible to articulate the mandible with the maxilla. The sample included 20th century dry skulls: 70 African-American (44 male, 26 female) and 64 European-American (49 male, 15 female), ranging in age from 21-105 (mean 47.1 +/- 19.9). The medial (M), central (C), and lateral (Lat) aspects of the right (R) and left (L) slopes of the articular eminence were measured in a sagittal plane. The R and L fossa depth also were measured. The raw absolute differences IR-LI and relative differences [IR-LI/IR+Llx100] of the articular slope angles (M, C, and Lat) and fossa depths were computed. Statistical analysis included paired t-tests, independent t-tests, and Pearson's correlation coefficients, significance at p groups in the raw absolute differences or relative differences of the M, C, and Lat slopes or fossa depths. No significant relationships were found between right-left asymmetry, age, or number of teeth. With only 10% of the subjects exhibiting symmetry of the glenoid fossa depths or articular slope angles, clinicians should consider bilateral asymmetry the norm and not an anomaly. PMID:16711269

  1. The Effect of Tooth Loss on the TM-joint Articular Eminence Inclination

    OpenAIRE

    Žabarović, D.; Jerolimov, V.; Carek, V.; Vojvodić, D.; Žabarović, K.; Buković Jr., D.

    2000-01-01

    The inclination between the posterior wall of the articular eminence and the referential plane (Frankfurt line) was measured on 137 dry skull specimens (78 with complete dental arches and 59 edentulous). Both left and right joints were measured using direct craniometric method. The results were compared with respect to the loss of teeth, side and sex. A large range of measured values of the eminence inclination shows great individual differences, so that the mean values can hav...

  2. Interplay between environmental factors, articular involvement, and HLA-B27 in patients with psoriatic arthritis.

    OpenAIRE

    Scarpa, R.; DEL PUENTE A; di Girolamo, C; Della Valle, G.; E. Lubrano; Oriente, P

    1992-01-01

    Medical records of 138 patients with psoriatic arthritis and 138 with rheumatoid arthritis were reviewed for the occurrence of an environmental factor triggering arthritis. Twelve (9%) of the patients with psoriatic arthritis had had an acute disorder immediately preceding onset of arthritis (an operation in four cases, articular trauma in three, abortion in two, myocardial infarction, thrombophlebitis, and phosphoric ester intoxication in one case each). Peripheral arthritis occurred in all ...

  3. Comminuted C2 Articular Pillar Fracture in a Patient With Multiple Sclerosis and Recurrent Falls.

    Science.gov (United States)

    Sault, Josiah D; Elliott, James M

    2015-12-01

    The patient was a 60-year-old woman, with long-standing balance deficits due to multiple sclerosis, referred to physical therapy by her primary care physician secondary to increasing fall frequency. Following evaluation, the physical therapist escorted the patient to her primary care physician's office, where a computed tomography scan was immediately performed, revealing a comminuted C2 articular pillar fracture. PMID:26620642

  4. Intra-articular membranous interposition detected by MRI in developmental dysplasia of the hip

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, W.; Itoi, Eiji; Sato, Kozo [Akita Univ. (Japan). Dept. of Orthopedic Surgery

    2000-12-01

    Intra-articular membranous interposition was detected by MRI in the hip joint with residual subluxation of a girl aged 5 years 10 months. This structure, which had low signal intensity on both T1- and T2-weighted images, separated the femoral head from the acetabulum. Histological examination revealed chondrometaplasia, which suggested that this interposition might be transformed to a surface cartilaginous tissue of the secondary acetabulum often observed in residual subluxation of the hip. (orig.)

  5. Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes

    OpenAIRE

    Kato, Tomohiro; Miyaki, Shigeru; Ishitobi, Hiroyuki; Nakamura, Yoshihiro; Nakasa, Tomoyuki; Lotz, Martin K.; Ochi, Mitsuo

    2014-01-01

    Introduction Osteoarthritis (OA) is a whole joint disease, and characterized by progressive degradation of articular cartilage, synovial hyperplasia, bone remodeling and angiogenesis in various joint tissues. Exosomes are a type of microvesicles (MVs) that may play a role in tissue-tissue and cell-cell communication in homeostasis and diseases. We hypothesized that exosomes function in a novel regulatory network that contributes to OA pathogenesis and examined the function of exosomes in comm...

  6. Intra-Articular Hyaluronic Acid Injections Vs. Dextrose Prolotherapy in the Treatment of Osteoarthritic Knee Pain

    OpenAIRE

    S Nasiripour; F Hassanzadeh Kiyabi; M Nikooseresht; Razavi, S; F Madadi; SM Hashemi

    2012-01-01

    Background: Conservative treatment needs to be tried prior to surgical treatment of knee osteoarthritis. This study was designed to evaluate the short-term effects of dextrose prolotherapy on pain relief and functional improvement in knee osteoarthritis in comparison with intra-articular hyaluronic acid injections. Methods: In this double blind clinical trial, 100 patients, aged 40-70 years, with complaints of knee pain lasting >3 months were recruited in Akhtar hospital during the years 2010...

  7. Intra-articular Corticosteroid Injection for the Treatment of Idiopathic Adhesive Capsulitis of the Shoulder

    OpenAIRE

    Marx, Robert G.; Malizia, Robert W.; Kenter, Keith; Wickiewicz, Thomas L.; Hannafin, Jo A.

    2007-01-01

    Treatment for idiopathic adhesive capsulitis or frozen shoulder of the shoulder is controversial. The hypothesis of the study is that intra-articular corticosteroid injection in the early stages of idiopathic adhesive capsulitis will lead to a razpid resolution of stiffness and symptoms. This is a retrospective cohort study of only patients with stage 1 or stage 2 adhesive capsulitis. The diagnosis was made by history and physical examination and only when other causes of pain and motion loss...

  8. Chondroprotective Effect of Kartogenin on CD44-Mediated Functions in Articular Cartilage and Chondrocytes

    OpenAIRE

    Ono, Yohei; Ishizuka, Shinya; Knudson, Cheryl B.; Knudson, Warren

    2014-01-01

    Objective: A recent report identified the small molecule kartogenin as a chondrogenic and chondroprotective agent. Since changes in hyaluronan metabolism occur during cartilage degeneration in osteoarthritis, we began studies to determine whether there was a connection between extracellular hyaluronan, CD44–hyaluronan interactions and the effects of kartogenin on articular chondrocytes. Methods: Chondrocytes cultured in monolayers, bioengineered neocartilages, or cartilage explants were treat...

  9. Mycobacterium Avium Arthritis with Extra-articular Abscess in a Patient with Mixed Connective Tissue Disease

    OpenAIRE

    Lee, Choong Won; Sung, Han Dong; Choi, Byong Moon; Kim, Chun Wook; Jun, Su Jin; Min, Sang Jo

    2003-01-01

    A case of Mycobacterium avium arthritis in a 39-year-old female patient with mixed connective tissue disease (MCTD) was reported. An extra-articular abscess had formed outside the knee joint and extended down the calf. A culture was taken of the abscess and synovial fluid disclosed Mycobacteriun avium. This was resistant to most anti-tuberculosis agents. A combination of anti-tuberculosis drugs followed a total resection of the abscess. We concluded that M avium septic arthritis could insidio...

  10. Significant Incidence of Extra-Articular Tibia Vara Affects Radiological Outcome of Total Knee Arthroplasty

    OpenAIRE

    Saibaba, Balaji; Dhillon, Mandeep S.; Chouhan, Devendra K; Kanojia, Rajendra K.; Prakash, Mahesh; Bachhal, Vikas

    2015-01-01

    Purpose To identify and quantify the presence of extra-articular tibia vara that might influence the mechanical axis alignment after total knee arthroplasty (TKA). Materials and Methods A total of 48 TKAs in 30 osteoarthritic Indian patients were prospectively evaluated. The hip-knee-ankle angle (HKA), joint line convergence angle, and varus angulation at the femur and tibia were measured from the preoperative and postoperative standing hip-to-ankle radiographs. Four different methods were us...

  11. Viscoelastic properties of bovine articular cartilage attached to subchondral bone at high frequencies

    Directory of Open Access Journals (Sweden)

    Shepherd Duncan ET

    2009-06-01

    Full Text Available Abstract Background Articular cartilage is a viscoelastic material, but its exact behaviour under the full range of physiological loading frequencies is unknown. The objective of this study was to measure the viscoelastic properties of bovine articular cartilage at loading frequencies of up to 92 Hz. Methods Intact tibial plateau cartilage, attached to subchondral bone, was investigated by dynamic mechanical analysis (DMA. A sinusoidally varying compressive force of between 16 N and 36 N, at frequencies from 1 Hz to 92 Hz, was applied to the cartilage surface by a flat indenter. The storage modulus, loss modulus and phase angle (between the applied force and the deformation induced were determined. Results The storage modulus, E', increased with increasing frequency, but at higher frequencies it tended towards a constant value. Its dependence on frequency, f, could be represented by, E' = Aloge (f + B where A = 2.5 ± 0.6 MPa and B = 50.1 ± 12.5 MPa (mean ± standard error. The values of the loss modulus (4.8 ± 1.0 MPa mean ± standard deviation were much less than the values of storage modulus and showed no dependence on frequency. The phase angle was found to be non-zero for all frequencies tested (4.9 ± 0.6°. Conclusion Articular cartilage is viscoelastic throughout the full range of frequencies investigated. The behaviour has implications for mechanical damage to articular cartilage and the onset of osteoarthritis. Storage modulus increases with frequency, until the plateau region is reached, and has a higher value than loss modulus. Furthermore, loss modulus does not increase with loading frequency. This means that more energy is stored by the tissue than is dissipated and that this effect is greater at higher frequencies. The main mechanism for this excess energy to be dissipated is by the formation of cracks.

  12. Radiolabeled anti granulocyte antibodies in the detection of osteo-articular prosthesis infection

    International Nuclear Information System (INIS)

    Radiolabeled anti-granulocyte antibodies (immunoscintigraphy) are of demonstrated effectiveness in the diagnosis of infection. The osteo-articular prosthesis infection, instead of its low prevalence, needs an accurate and fast diagnosis. The immunoscintigraphy in this group of patients is a debated subject as the results seem to be related to the experience, interpretation criteria and patients clinical features. In general, immunoscintigraphy is an useful technique with an easy, safe and fast preparation. (author)

  13. Tissue engineering for articular cartilage repair – the state of the art

    OpenAIRE

    Johnstone, B.; Alini, M.; M Cucchiarini; GR Dodge; Eglin, D.; F Guilak; Madry, H.; Mata, A.; RL Mauck; CE Semino; MJ Stoddart

    2013-01-01

    Articular cartilage exhibits little capacity for intrinsic repair, and thus even minor injuries or lesions may lead to progressive damage and osteoarthritic joint degeneration, resulting in significant pain and disability. While there have been numerous attempts to develop tissue-engineered grafts or patches to repair focal chondral and osteochondral defects, there remain significant challenges in the clinical application of cell-based therapies for cartilage repair. This paper reviews the cu...

  14. Freeze-thaw treatment effects on the dynamic mechanical properties of articular cartilage

    Directory of Open Access Journals (Sweden)

    Muldrew Ken

    2010-10-01

    Full Text Available Abstract Background As a relatively non-regenerative tissue, articular cartilage has been targeted for cryopreservation as a method of mitigating a lack of donor tissue availability for transplant surgeries. In addition, subzero storage of articular cartilage has long been used in biomedical studies using various storage temperatures. The current investigation studies the potential for freeze-thaw to affect the mechanical properties of articular cartilage through direct comparison of various subzero storage temperatures. Methods Both subzero storage temperature as well as freezing rate were compared using control samples (4°C and samples stored at either -20°C or -80°C as well as samples first snap frozen in liquid nitrogen (-196°C prior to storage at -80°C. All samples were thawed at 37.5°C to testing temperature (22°C. Complex stiffness and hysteresis characterized load resistance and damping properties using a non-destructive, low force magnitude, dynamic indentation protocol spanning a broad loading rate range to identify the dynamic viscoelastic properties of cartilage. Results Stiffness levels remained unchanged with exposure to the various subzero temperatures. Hysteresis increased in samples snap frozen at -196°C and stored at -80°C, though remained unchanged with exposure to the other storage temperatures. Conclusions Mechanical changes shown are likely due to ice lens creation, where frost heave effects may have caused collagen damage. That storage to -20°C and -80°C did not alter the mechanical properties of articular cartilage shows that when combined with a rapid thawing protocol to 37.5°C, the tissue may successfully be stored at subzero temperatures.

  15. Fluid collections and juxta-articular cystic lesions of the shoulder: spectrum of MRI findings

    International Nuclear Information System (INIS)

    The MR imaging features of fluid collections and juxta-articular cystic lesions of the shoulder are discussed, with special focus on those related to subacromial impingement and rotator cuff tears. Other more unusual fluid collections and cystic lesions are described, including rice-bodies bursitis, idiopathic synovial osteochondromatosis, dialysis-related amyloid arthropathy, hemophilic arthropathy, infectious conditions, non-infectious inflammatory arthritis, and paralabral cysts. (orig.)

  16. A bi-articular model for scapular-humeral rhythm reconstruction through data from wearable sensors

    OpenAIRE

    Lorussi, Federico; Carbonaro, Nicola; Rossi, Danilo De; Tognetti, Alessandro

    2016-01-01

    Background Patient-specific performance assessment of arm movements in daily life activities is fundamental for neurological rehabilitation therapy. In most applications, the shoulder movement is simplified through a socket-ball joint, neglecting the movement of the scapular-thoracic complex. This may lead to significant errors. We propose an innovative bi-articular model of the human shoulder for estimating the position of the hand in relation to the sternum. The model takes into account bot...

  17. Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis

    OpenAIRE

    Goldring, Steven R.

    2012-01-01

    The articular cartilage and the subchondral bone form a biocomposite that is uniquely adapted to the transfer of loads across the diarthrodial joint. During the evolution of the osteoarthritic process biomechanical and biological processes result in alterations in the composition, structure and functional properties of these tissues. Given the intimate contact between the cartilage and bone, alterations of either tissue will modulate the properties and function of the other joint component. T...

  18. Mechanical Stress and ATP Synthesis are coupled by Mitochondrial Oxidants in Articular Cartilage

    OpenAIRE

    Wolff, Katherine J; Ramakrishnan, Prem S.; Brouillette, Marc J.; Journot, Brice; Mckinley, Todd O; Buckwalter, JA; Martin, James A.

    2012-01-01

    Metabolic adaptation of articular cartilage under joint loading is evident and matrix synthesis seems to be critically tied to ATP. Chondrocytes utilize the glycolytic pathway for energy requirements but seem to require mitochondrial reactive oxygen species (ROS) to sustain ATP synthesis. The role of ROS in regulating ATP reserves under a mechanically active environment is not clear. It is believed that physiological strains cause deformation of the mitochondria, potentially releasing ROS for...

  19. Linking Cellular and Mechanical Processes in Articular Cartilage Lesion Formation: A Mathematical Model

    OpenAIRE

    Kapitanov, Georgi I.; Wang, Xiayi; Ayati, Bruce P; Brouillette, Marc J.; Martin, James A.

    2016-01-01

    A severe application of stress on articular cartilage can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis. We constructed a multiscale mathematical model of the process with three components: cellular, chemical, and mechanical. The cellular component describes the different chondrocyte states according to the chemicals these cells release. The chemical component models the change in concentrations of those chemicals. The mechanical component cont...

  20. Strain-Dependent Oxidant Release in Articular Cartilage Originates from Mitochondria

    OpenAIRE

    J, Brouillette M; S, Ramakrishnan P; M, Wagner V; E, Sauter E; J, Journot B; O, McKinley T; A, Martin J

    2013-01-01

    Mechanical loading is essential for articular cartilage homeostasis and plays a central role in the cartilage pathology, yet the mechanotransduction processes that underlie these effects remain unclear. Previously we showed that lethal amounts of reactive oxygen species (ROS) were liberated from the mitochondria in response to mechanical insult, and that chondrocyte deformation may be a source of ROS. To this end, we hypothesized that mechanically-induced mitochondrial ROS is related to the m...

  1. Magnetic resonance imaging of articular cartilage abnormalities of the far posterior femoral condyle of the knee

    Energy Technology Data Exchange (ETDEWEB)

    Ogino, Shuhei; Huang, Thomas; Watanabe, Atsuya; Iranpour-Boroujeni, Tannaz; Yoshioka, Hiroshi (Dept. of Radiology, Brigham and Women' s Hospital, Boston, MA (United States)), e-mail: hiroshi@uci.edu

    2010-01-15

    Background: Incidental articular cartilage lesions of the far posterior femoral condyle (FPFC) are commonly detected. Whether or not these cartilage lesions are symptomatic or clinically significant is unknown. Purpose: To characterize and assess prevalence of articular cartilage abnormalities of the FPFC and associated bone marrow edema (BME) and/or internal derangements through magnetic resonance (MR) images. Material and Methods: 654 knee MR examinations were reviewed retrospectively. Sagittal fast spin-echo proton density-weighted images with and without fat suppression were acquired with a 1.5T scanner, and were evaluated by two readers by consensus. The following factors were assessed: 1) the prevalence of cartilage abnormalities, 2) laterality, 3) the type of cartilage abnormalities, 4) cartilage abnormality grading, 5) associated BME, 6) complications such as meniscal injury and cruciate ligament injury, and 7) knee alignment (femorotibial angle [FTA]). Results: Articular cartilage abnormalities of the FPFC were demonstrated in 157 of the 654 patients (24%). Of these, 40 patients demonstrated medial and lateral FPFC cartilage abnormalities and were thus counted as 80 cases. Focal lateral FPFC abnormalities were demonstrated in 117 of 197 cases (59.4%), while diffuse lateral FPFC abnormalities were demonstrated in 24 of 197 cases (12.2%). Focal medial FPFC abnormalities were demonstrated in 23 of 197 cases (11.6%), while diffuse medial FPFC abnormalities were demonstrated in 33 of 197 cases (16.8%). No statistically significant pattern of associated BME, FTA, or internal derangements including meniscal and cruciate ligament injury was demonstrated. Conclusion: Articular cartilage abnormalities of the FPFC are common and were demonstrated in 24% of patients or 30% of cases. Lateral FPFC abnormalities occur 2.5 times more frequently than medial FPFC abnormalities and were more frequently focal compared with medial cohorts. BME is associated in 36.5% of cases

  2. Original Functional Rehabilitation Programme Based on Healing Physiology After Reconstruction of Articular Cartilage in Knee Joint

    OpenAIRE

    Guliyan, Volodymyr; Plenzler, Marcin; Straszewski, Dariusz; Paśnik, Marcin; Korbolewska, Olga; Suszczyński, Wojciech; Śmigielski, Robert

    2014-01-01

    Objectives: The evaluation of the quality of articular cartilage remodelling by means of arthroscopy findings and MRI imaging in a patient, who completed the original rehabilitation program. Methods: The rehabilitation program was conducted according to the Carolina Medical Center rehabilitation protocol. The patient was a 46 years old woman with fourth-degree cartilage damage (Outerbridge classification) located on the right medial femoral condyle of the following size: 1.5x2cm and 1x1.5cm. ...

  3. Arthroscopic study of injuries in articular fractures of distal radius extremity

    OpenAIRE

    Araf, Marcelo; Mattar, Rames

    2014-01-01

    OBJECTIVE: To analyze the incidence of wrist ligament and cartilage associated fractures of the distal radius, through arthroscopy, correlating with AO/ASIF classification. METHODS: Thirty patients aged between 20 and 50 years old, with closed fracture from groups B and C according to AO/ASIF classification were selected. All of them were submitted to wrist arthroscopy to address intra-articular injuries and reduction and osteosynthesis of the fracture. RESULTS: A high incidence of intra-arti...

  4. Finite element simulation of articular contact mechanics with quadratic tetrahedral elements.

    Science.gov (United States)

    Maas, Steve A; Ellis, Benjamin J; Rawlins, David S; Weiss, Jeffrey A

    2016-03-21

    Although it is easier to generate finite element discretizations with tetrahedral elements, trilinear hexahedral (HEX8) elements are more often used in simulations of articular contact mechanics. This is due to numerical shortcomings of linear tetrahedral (TET4) elements, limited availability of quadratic tetrahedron elements in combination with effective contact algorithms, and the perceived increased computational expense of quadratic finite elements. In this study we implemented both ten-node (TET10) and fifteen-node (TET15) quadratic tetrahedral elements in FEBio (www.febio.org) and compared their accuracy, robustness in terms of convergence behavior and computational cost for simulations relevant to articular contact mechanics. Suitable volume integration and surface integration rules were determined by comparing the results of several benchmark contact problems. The results demonstrated that the surface integration rule used to evaluate the contact integrals for quadratic elements affected both convergence behavior and accuracy of predicted stresses. The computational expense and robustness of both quadratic tetrahedral formulations compared favorably to the HEX8 models. Of note, the TET15 element demonstrated superior convergence behavior and lower computational cost than both the TET10 and HEX8 elements for meshes with similar numbers of degrees of freedom in the contact problems that we examined. Finally, the excellent accuracy and relative efficiency of these quadratic tetrahedral elements was illustrated by comparing their predictions with those for a HEX8 mesh for simulation of articular contact in a fully validated model of the hip. These results demonstrate that TET10 and TET15 elements provide viable alternatives to HEX8 elements for simulation of articular contact mechanics. PMID:26900037

  5. Intra-articular bupivacaine or bupivacaine and morphine after ACL reconstruction

    OpenAIRE

    Danieli, Marcus Vinicius; Cavazzani Neto, Antonio; Herrera, Paulo Adilson

    2012-01-01

    Objective Reconstructive surgery of the ACL is one of the most commonly performed surgeries today and the control of postoperative pain is part of the priorities of the surgeon. Within the arsenal of analgesia we have the intra-articular application of drugs, and the most studied one is bupivacaine with or without morphine. This study compared the application of bupivacaine with or without morphine with a control group after ACL reconstruction with flexor tendon graft. Methods Forty-five pati...

  6. Large Intra-Articular Anterior Cruciate Ligament Ganglion Cyst, Presenting with Inability to Flex the Knee

    OpenAIRE

    Philip Pastides; Davinder Paul Singh Baghla; Sreeram Penna; Vivek Gulati; Jake Sloane

    2010-01-01

    A 41-year-old female presented with a 3-month history of gradually worsening anterior knee pain, swelling and inability to flex the knee. Magnetic resonance imaging (MRI) revealed a large intra-articular cystic swelling anterior to the anterior cruciate ligament (ACL), extending into the Hoffa's infrapatellar fat pad. Following manipulation under anaesthesia and arthroscopic debridement of the cyst, the patient's symptoms were relieved with restoration of normal knee motion. ACL ganglion cyst...

  7. Operative treatment of intra-articular calcaneal fractures with calcaneal plates and its complications

    Directory of Open Access Journals (Sweden)

    Rak Vaclav

    2009-01-01

    Full Text Available Background: In a retrospective study we analysed intra-articular calcaneal fracture treatment by comparing results and complications related to fracture stabilization with nonlocking calcaneal plates and locking compression plates. Materials and Methods: We performed 76 osteosynthesis (67 patients of intra-articular calcaneal fractures using the standard extended lateral approach from February 2004 to October 2007. Forty-two operations using nonlocking calcaneal plates (group A were performed during the first three years, and 34 calcaneal fractures were stabilized using locking compression plates (group B in 2007. In the Sanders type IV fractures, reconstruction of the calcaneal shape was attempted. Depending on the type of late complication, we performed subtalar arthroscopy in six cases, arthroscopically assisted subtalar distraction bone block arthrodesis in six cases, and plate removal with lateral-wall decompression in five cases. The patients were evaluated by the AOFAS Ankle-Hindfoot Scale. Results: Wound healing complications were 7/42 (17% in group A and 1/34 (3% in group B. No patient had deep osseous infection or foot rebound compartment syndrome. Preoperative size of Bφhler´s angle correlated with postoperative clinical results in both groups. There were no late complications necessitating corrective procedure or arthroscopy until December 2008 in Group B. All late complications ccurred in Group A. The overall results according to the AOFAS Ankle Hindfoot Scale were good or excellent in 23/42 (55% in group A and in 30/34 (85% in group B. Conclusion: Open reduction and internal fixation of intra-articular calcaneal fractures has become a standard surgical method. Fewer complications and better results related to treatment with locking compression plates confirmed in comparison to nonlocking ones were noted for all Sanders types of intra-articular calcaneal fractures. Age and Sanders type IV fractures are not considered to be the

  8. MANAGEMENT OF INTRA-ARTICULAR CALCANEAL FRACTURES BY CLOSED REDUCTION WITH PERCUTANEOUS STEINMANN PIN

    OpenAIRE

    Padmanabh, MR; Niaz; Ramachandra,

    2014-01-01

    BACKGROUND & OBJECTIVES: Calcaneum is the most common tarsal bone to fracture and is attended by considerable morbidity. Many treatment techniques are described in literature but indications for specific techniques are vague. This study analyzes the outcome of treatment of intra articular calcaneum fractures treated by Essex-Lopresti technique. METHODS: Between January 2011 and December 2012, 20 patients with tongue-type fracture of Calcaneum who got admitted at Srinivas I...

  9. Adverse effects of extra-articular corticosteroid injections: a systematic review

    Directory of Open Access Journals (Sweden)

    Brinks Aaltien

    2010-09-01

    Full Text Available Abstract Background To estimate the occurrence and type of adverse effects after application of an extra-articular (soft tissue corticosteroid injection. Methods A systematic review of the literature was made based on a PubMed and Embase search covering the period 1956 to January 2010. Case reports were included, as were prospective and retrospective studies that reported adverse events of corticosteroid injection. All clinical trials which used extra-articular corticosteroid injections were examined. We divided the reported adverse events into major (defined as those needing intervention or not disappearing and minor ones (transient, not requiring intervention. Results The search yielded 87 relevant studies:44 case reports, 37 prospective studies and 6 retrospective studies. The major adverse events included osteomyelitis and protothecosis; one fatal necrotizing fasciitis; cellulitis and ecchymosis; tendon ruptures; atrophy of the plantar fat was described after injecting a neuroma; and local skin effects appeared as atrophy, hypopigmentation or as skin defect. The minor adverse events effects ranged from skin rash to flushing and disturbed menstrual pattern. Increased pain or steroid flare after injection was reported in 19 studies. After extra-articular injection, the incidence of major adverse events ranged from 0-5.8% and that of minor adverse events from 0-81%. It was not feasible to pool the risk for adverse effects due to heterogeneity of study populations and difference in interventions and variance in reporting. Conclusion In this literature review it was difficult to accurately quantify the incidence of adverse effects after extra-articular corticosteroid injection. The reported adverse events were relatively mild, although one fatal reaction was reported.

  10. Guidelines for the Design and Conduct of Clinical Studies in Knee Articular Cartilage Repair

    OpenAIRE

    Mithoefer, Kai; Saris, Daniel B.F.; Farr, Jack; Kon, Elizaveta; Zaslav, Kenneth; Cole, Brian J.; Ranstam, Jonas; Yao, Jian; Shive, Matthew; Levine, David; Dalemans, Wilfried; Brittberg, Mats

    2011-01-01

    Objective: To summarize current clinical research practice and develop methodological standards for objective scientific evaluation of knee cartilage repair procedures and products. Design: A comprehensive literature review was performed of high-level original studies providing information relevant for the design of clinical studies on articular cartilage repair in the knee. Analysis of cartilage repair publications and synopses of ongoing trials were used to identify important criteria for t...

  11. Technique for ultrasound-guided intraarticular cervical articular process injection in the dog.

    Science.gov (United States)

    Levy, Matthew; Gaschen, Lorrie; Rademacher, Nathalie; Bragulla, Hermann

    2014-01-01

    Ultrasound-guided intraarticular injection of cervical articular process joints is a well-established procedure in both humans and horses for neck pain resulting from osteoarthritis, but the technique has not been described in dogs. Aims of this study were to describe the ultrasonographic anatomy and landmarks for cervical articular process joint injections in the dog, develop a technique for articular process joint injections using these landmarks, and determine the accuracy of injections and factors that may influence it. Eleven canine cadavers were used and bilateral joint spaces from C2-3 to C7-T1 were injected under ultrasound guidance with a blue radiopaque solution. A computed tomographic scan was acquired following each injection, and an injection score was assigned and compared with other patient-specific factors. Of the 132 injections performed, 110 (83.3%) were intraarticular, 20 (15.1%) were periarticular within 5 mm, and 2 (1.5%) were periarticular beyond 5 mm from the joint. There was no significant difference in mean scores between dogs. Only C2-3 had a significantly lower mean score than any other joint. There was no significant correlation between injection score and any other factors measured. The transverse processes of the cervical vertebrae served as excellent ultrasonographic landmarks for identifying the cervical articular process joints in dogs regardless of the size of the dog or location along the vertebrae. Accuracy of ultrasound-guided intraarticular process joint injection was 83% in dogs and similar to published techniques in horses. Further studies are needed to examine the safety and efficacy of this procedure in live animals. PMID:24506833

  12. Andrographolide Enhances Proliferation and Prevents Dedifferentiation of Rabbit Articular Chondrocytes: An In Vitro Study

    OpenAIRE

    Li-ke Luo; Qing-jun Wei; Lei Liu; Li Zheng; Jin-min Zhao

    2015-01-01

    As the main active constituent of Andrographis paniculata that was applied in treatment of many diseases including inflammation in ancient China, andrographolide (ANDRO) was found to facilitate reduction of edema and analgesia in arthritis. This suggested that ANDRO may be promising anti-inflammatory agent to relieve destruction and degeneration of cartilage after inflammation. In this study, the effect of ANDRO on rabbit articular chondrocytes in vitro was investigated. Results showed that n...

  13. Collagen metabolism of human osteoarthritic articular cartilage as modulated by bovine collagen hydrolysates

    OpenAIRE

    Saskia Schadow; Hans-Christian Siebert; Günter Lochnit; Jens Kordelle; Markus Rickert; Jürgen Steinmeyer

    2013-01-01

    Destruction of articular cartilage is a characteristic feature of osteoarthritis (OA). Collagen hydrolysates are mixtures of collagen peptides and have gained huge public attention as nutriceuticals used for prophylaxis of OA. Here, we evaluated for the first time whether different bovine collagen hydrolysate preparations indeed modulate the metabolism of collagen and proteoglycans from human OA cartilage explants and determined the chemical composition of oligopeptides representing collagen ...

  14. Viscoelastic properties of bovine knee joint articular cartilage: dependency on thickness and loading frequency

    OpenAIRE

    Espino, Daniel M; Shepherd, Duncan ET; Hukins, David WL

    2014-01-01

    Background The knee is an incongruent joint predisposed to developing osteoarthritis, with certain regions being more at risk of cartilage degeneration even in non-osteoarthrosed joints. At present it is unknown if knee regions prone to cartilage degeneration have similar storage and/or loss stiffness, and frequency-dependent trends, to other knee joint cartilage. The aim of this study was to determine the range of frequency-dependent, viscoelastic stiffness of articular cartilage across the ...

  15. Manifestações articulares em pacientes com doença de Crohn e retocolite ulcerativa Articular manifestations in patients with Crohn's disease and ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Cristina Costa Duarte Lanna

    2006-06-01

    Full Text Available Os sintomas articulares constituem a manifestação extra-intestinal mais comum em pacientes com doença de Crohn e com retocolite ulcerativa. Reconhecida como artrite colítica, e mais recentemente, artrite enteropática, está classificada como uma das doenças do grupo das espondiloartropatias. Reconhecidamente, há dois padrões de acometimento articular: 1 periférico, habitualmente, associado aos períodos de atividade da doença intestinal e sem associação com o antígeno HLA B27, e 2 axial, caracterizado por espondilite e sacroiliíte, com curso clínico e radiográfico independente da doença intestinal e associado ao HLA B27.Joint involvement is the most commom extraintestinal manifestation in patients with Crohn's disease and ulcerative colitis. The colitic arthritis, lately called enteropathic arthritis, is classified as one of the diseases of the spondyloarthropathies group. There are two patterns of joint involvement: 1 peripheral arthritis, usually coincides with exacerbations of the inflammatory bowel disease and is not associated with the HLA B27 antigen; and 2 axial involvement, characterized by spondylitis and sacroiliitis, which the clinical course is independent of the intestinal disease, and has an association with HLA B27.

  16. Efficacy of Intra-articular Local Anesthetics in Total Knee Arthroplasty.

    Science.gov (United States)

    Fang, Rui; Liu, Zhenfeng; Alijiang, Asila; Jia, Heng; Deng, Yingjie; Song, Yucheng; Meng, Qingcai

    2015-07-01

    Pain management after total knee arthroplasty (TKA) remains among the most important challenges for patients with TKA. Intra-articular local anesthetic has been shown to reduce postoperative pain following TKA. However, studies report conflicting results. This meta-analysis evaluated the efficacy and safety of single-dose intra-articular local anesthetics for pain control after TKA. Databases (Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, and Chinese Biomedical Databases) were searched to identify randomized, controlled trials comparing local anesthetic with placebo in patients undergoing TKA. Data were extracted independently by 2 researchers using a standardized form. Risk of bias was assessed with the use of the Cochrane Collaboration's tool for assessing the risk of bias by 2 observers. Relative risk, standardized mean difference, and corresponding 95% confidence interval were calculated. Seventeen trials met the inclusion criteria, for a total of 1338 participants. The results showed that, compared with the placebo group, the single local anesthetic group had a significant lower pain score with rest at 4, 8, 24, and 48 hours; less opioid consumption at 24, 48, and 72 hours postoperatively; and greater range of motion at 24, 48, and 72 hours. There were no significant differences between the 2 groups in length of hospital stay, nausea and vomiting, pruritus, sedation, or deep venous thrombosis. The study findings showed that pain relief after TKA was significantly better with intra-articular local anesthetic than with placebo. PMID:26186318

  17. Poroelastic response of articular cartilage by nanoindentation creep tests at different characteristic lengths.

    Science.gov (United States)

    Taffetani, M; Gottardi, R; Gastaldi, D; Raiteri, R; Vena, P

    2014-07-01

    Nanoindentation is an experimental technique which is attracting increasing interests for the mechanical characterization of articular cartilage. In particular, time dependent mechanical responses due to fluid flow through the porous matrix can be quantitatively investigated by nanoindentation experiments at different penetration depths and/or by using different probe sizes. The aim of this paper is to provide a framework for the quantitative interpretation of the poroelastic response of articular cartilage subjected to creep nanoindentation tests. To this purpose, multiload creep tests using spherical indenters have been carried out on saturated samples of mature bovine articular cartilage achieving two main quantitative results. First, the dependence of indentation modulus in the drained state (at equilibrium) on the tip radius: a value of 500 kPa has been found using the large tip (400 μm radius) and of 1.7 MPa using the smaller one (25 μm). Secon, the permeability at microscopic scale was estimated at values ranging from 4.5×10(-16) m(4)/N s to 0.1×10(-16) m(4)/N s, from low to high equivalent deformation. Consistently with a poroelastic behavior, the size-dependent response of the indenter displacement disappears when characteristic size and permeability are accounted for. For comparison purposes, the same protocol was applied to intrinsically viscoelastic homogeneous samples of polydimethylsiloxane (PDMS): both indentation modulus and time response have been found size-independent. PMID:24814573

  18. Highly nonlinear stress-relaxation response of articular cartilage in indentation: Importance of collagen nonlinearity.

    Science.gov (United States)

    Mäkelä, J T A; Korhonen, R K

    2016-06-14

    Modern fibril-reinforced computational models of articular cartilage can include inhomogeneous tissue composition and structure, and nonlinear mechanical behavior of collagen, proteoglycans and fluid. These models can capture well experimental single step creep and stress-relaxation tests or measurements under small strains in unconfined and confined compression. Yet, it is known that in indentation, especially at high strain velocities, cartilage can express highly nonlinear response. Different fibril reinforced poroelastic and poroviscoelastic models were used to assess measured highly nonlinear stress-relaxation response of rabbit articular cartilage in indentation. Experimentally measured depth-dependent volume fractions of different tissue constituents and their mechanical nonlinearities were taken into account in the models. In particular, the collagen fibril network was modeled using eight separate models that implemented five different constitutive equations to describe the nonlinearity. These consisted of linear elastic, nonlinear viscoelastic and multiple nonlinear elastic representations. The model incorporating the most nonlinearly increasing Young׳s modulus of collagen fibrils as a function of strain captured best the experimental data. Relative difference between the model and experiment was ~3%. Surprisingly, the difference in the peak forces between the experiment and the model with viscoelastic collagen fibrils was almost 20%. Implementation of the measured volume fractions did not improve the ability of the model to capture the measured mechanical data. These results suggest that a highly nonlinear formulation for collagen fibrils is needed to replicate multi-step stress-relaxation response of rabbit articular cartilage in indentation with high strain rates. PMID:27130474

  19. Behavioral trait of morningness-eveningness in association with articular and spinal diseases in a population.

    Science.gov (United States)

    Merikanto, Ilona; Lahti, Tuuli; Seitsalo, Seppo; Kronholm, Erkki; Laatikainen, Tiina; Peltonen, Markku; Vartiainen, Erkki; Partonen, Timo

    2014-01-01

    Earlier studies have revealed that the more the preference to schedule daily activities towards the evening hours is, the higher the odds for a range of health hazards are. Therefore, we wanted to analyze, whether the behavioral trait of morningness-eveningness is associated with articular and spinal diseases or those with musculoskeletal disorders. Participants (n = 6089), as part of the National FINRISK 2007 Study, were derived from the general population, aged 25 to 74 years, living in Finland. Chronotype was assessed based on six items from the original Horne-Östberg Morningness-Eveningness Questionnaire. Information about risk factors and the diagnoses of articular and spinal diseases were based on the self-reported information. Our results suggest that Evening-types have higher odds for articular and spinal diseases as compared with Morning-types, and this risk is heightened especially regarding spinal disease and backache (odds ratios of 1.8 to 2.1, and 1.6 to 1.8, respectively) and remains significant after controlling for the sex, age, education, civil status, physical activity, alcohol use, and smoking, and additionally for the body-mass index, insufficient sleep, or depressive symptoms. PMID:25470493

  20. Behavioral trait of morningness-eveningness in association with articular and spinal diseases in a population.

    Directory of Open Access Journals (Sweden)

    Ilona Merikanto

    Full Text Available Earlier studies have revealed that the more the preference to schedule daily activities towards the evening hours is, the higher the odds for a range of health hazards are. Therefore, we wanted to analyze, whether the behavioral trait of morningness-eveningness is associated with articular and spinal diseases or those with musculoskeletal disorders. Participants (n = 6089, as part of the National FINRISK 2007 Study, were derived from the general population, aged 25 to 74 years, living in Finland. Chronotype was assessed based on six items from the original Horne-Östberg Morningness-Eveningness Questionnaire. Information about risk factors and the diagnoses of articular and spinal diseases were based on the self-reported information. Our results suggest that Evening-types have higher odds for articular and spinal diseases as compared with Morning-types, and this risk is heightened especially regarding spinal disease and backache (odds ratios of 1.8 to 2.1, and 1.6 to 1.8, respectively and remains significant after controlling for the sex, age, education, civil status, physical activity, alcohol use, and smoking, and additionally for the body-mass index, insufficient sleep, or depressive symptoms.

  1. Nitrous Oxide sedation for intra-articular injection in juvenile idiopathic arthritis

    Directory of Open Access Journals (Sweden)

    Harel Liora

    2008-01-01

    Full Text Available Abstract Background Intra-articular corticosteroid injection in juvenile idiopathic arthritis (JIA is often associated with anxiety and pain. Recent reports advocate the use of nitrous oxide (NO, a volatile gas with analgesic, anxiolytic and sedative properties. Objective To prospectively evaluate the effectiveness and safety of NO analgesia for intra-articular corticosteroid injection in JIA, and to assess patients and staff satisfaction with the treatment. Methods NO was administered to JIA patients scheduled for joint injection. The patient, parent, physician and nurse completed visual-analog scores (VAS (0–10 for pain, and a 5-point satisfaction scale. Change in heart rate (HR during the procedure was recorded in order to examine physiologic response to pain and stress. Patient's behavior and adverse reactions were recorded. Results 54 procedures (72 joints were performed, 41 females, 13 males; 39 Jewish, 13 Arab; mean age was 12.2 ± 4.7 year. The median VAS pain score for patients, parents, physicians and nurses was 3. The HR increased ≥ 15% in 10 patients. They had higher VAS scores as evaluated by the staff. The median satisfaction level of the parents and staff was 3.0 and 5.0 respectively. Adverse reactions were mild. Conclusion NO provides effective and safe sedation for JIA children undergoing intra-articular injections.

  2. The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes

    Directory of Open Access Journals (Sweden)

    Leilei Zhong

    2015-08-01

    Full Text Available Hypertrophic differentiation of chondrocytes is a main barrier in application of mesenchymal stem cells (MSCs for cartilage repair. In addition, hypertrophy occurs occasionally in osteoarthritis (OA. Here we provide a comprehensive review on recent literature describing signal pathways in the hypertrophy of MSCs-derived in vitro differentiated chondrocytes and chondrocytes, with an emphasis on the crosstalk between these pathways. Insight into the exact regulation of hypertrophy by the signaling network is necessary for the efficient application of MSCs for articular cartilage repair and for developing novel strategies for curing OA. We focus on articles describing the role of the main signaling pathways in regulating chondrocyte hypertrophy-like changes. Most studies report hypertrophic differentiation in chondrogenesis of MSCs, in both human OA and experimental OA. Chondrocyte hypertrophy is not under the strict control of a single pathway but appears to be regulated by an intricately regulated network of multiple signaling pathways, such as WNT, Bone morphogenetic protein (BMP/Transforming growth factor-β (TGFβ, Parathyroid hormone-related peptide (PTHrP, Indian hedgehog (IHH, Fibroblast growth factor (FGF, Insulin like growth factor (IGF and Hypoxia-inducible factor (HIF. This comprehensive review describes how this intricate signaling network influences tissue-engineering applications of MSCs in articular cartilage (AC repair, and improves understanding of the disease stages and cellular responses within an OA articular joint.

  3. Absence of the articular disc in the tasmanian devil temporomandibular joint.

    Science.gov (United States)

    Hayashi, K; Sugisaki, M; Kino, K; Ishikawa, T; Sugisaki, M; Abe, S

    2013-12-01

    The articular disc of the temporomandibular joint is a constant structure in mammals. According to Parsons' report in 1900, however, it is absent in four animals: the armadillo, two kinds of monotremes and the Tasmanian devil. Thereafter, no research was performed to confirm this observation. The aim of this study was to determine by anatomical and histological examination whether the Tasmanian devil has an articular disc in its temporomandibular joint. Six fresh frozen corpses and one dry skull of Tasmanian devils were obtained from the School of Zoology, University of Tasmania. The corpses were dissected and the morphology of the temporomandibular joint was carefully observed by gross anatomical and histological examination. The structure of the temporomandibular joint of the dry skull was examined macroscopically and by micro-computed tomography. In all cases, absence of the articular disc in the Tasmanian devil temporomandibular joint was morphologically confirmed. The surface layer of both the condyle and the glenoid fossa comprised a thick fibrous tissue. Micro-computed tomography revealed dense and fine trabecular bone in the condyle. The thick fibrous tissue covering the condyle and high-density trabecular bone in the condyle might play a role in absorption against powerful mastication and heavy loading of the Tasmanian devil temporomandibular joint. PMID:23438215

  4. Intra-Articular Corticosteroids in Addition to Exercise for Reducing Pain Sensitivity in Knee Osteoarthritis

    DEFF Research Database (Denmark)

    Soriano-Maldonado, Alberto; Klokker, Louise; Bartholdy, Cecilie;

    2016-01-01

    OBJECTIVE: To assess the effects of one intra-articular corticosteroid injection two weeks prior to an exercise-based intervention program for reducing pain sensitivity in patients with knee osteoarthritis (OA). DESIGN: Randomized, masked, parallel, placebo-controlled trial involving 100 particip......OBJECTIVE: To assess the effects of one intra-articular corticosteroid injection two weeks prior to an exercise-based intervention program for reducing pain sensitivity in patients with knee osteoarthritis (OA). DESIGN: Randomized, masked, parallel, placebo-controlled trial involving 100...... the injections all participants undertook a 12-week supervised exercise program. Main outcomes were changes from baseline in pressure-pain sensitivity (pressure-pain threshold [PPT] and temporal summation [TS]) assessed using cuff pressure algometry on the calf. These were exploratory outcomes from a...... analyzed. The mean group difference in changes from baseline at week 14 was 0.6 kPa (95% CI: -1.7 to 2.8; P = 0.626) for PPT and 384 mm×sec (95% CI: -2980 to 3750; P = 0.821) for TS. CONCLUSIONS: These results suggest that adding intra-articular corticosteroid injection 2 weeks prior to an exercise program...

  5. T2* mapping of articular cartilage: current status of research and first clinical applications.

    Science.gov (United States)

    Andreisek, Gustav; Weiger, Markus

    2014-01-01

    T2* mapping is a relatively new method for the compositional assessment of the articular cartilage. Typically, a multigradient echo or an ultrashort echo time imaging technique with a range of short and very short echo times is used. In most studies, imaging is performed at a high field strength, that is, 3 and 7 T. Postprocessing includes exponential fitting of relaxation decay and manual region-of-interest-based measurements of T2* times on T2* maps. Detailed analyses of T2* times of articular cartilage have shown distinct T2* components with shorter and longer T2* times. Moreover, there is a zonal distribution with a significant depthwise gradient of T2*, with relatively short times near the osteochondral junction and relatively long times at the cartilage's surface. T2* times of normal articular cartilage at the knee are, when averaged over the whole cartilage thickness and using monoexponential fitting, approximately 20 milliseconds. The results of recent studies have shown a good test-retest as well as interreader and intrareader reliabilities for T2* mapping. This article provides a descriptive review of the current literature, briefly discusses the technique itself, and provides an outlook on future research questions and possible clinical applications. PMID:24056113

  6. Treatment of intra-articular fractures of the distal radius: fluoroscopic or arthroscopic reduction?

    Science.gov (United States)

    Varitimidis, S E; Basdekis, G K; Dailiana, Z H; Hantes, M E; Bargiotas, K; Malizos, K

    2008-06-01

    In a randomised prospective study, 20 patients with intra-articular fractures of the distal radius underwent arthroscopically- and fluoroscopically-assisted reduction and external fixation plus percutaneous pinning. Another group of 20 patients with the same fracture characteristics underwent fluoroscopically-assisted reduction alone and external fixation plus percutaneous pinning. The patients were evaluated clinically and radiologically at follow-up of 24 months. The Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire and modified Mayo wrist score were used at 3, 9, 12 and 24 months postoperatively. In the arthroscopically- and fluoroscopically-assisted group, triangular fibrocartilage complex tears were found in 12 patients (60%), complete or incomplete scapholunate ligament tears in nine (45%), and lunotriquetral ligament tears in four (20%). They were treated either arthroscopically or by open operation. Patients who underwent arthroscopically- and fluoroscopically-assisted treatment had significantly better supination, extension and flexion at all time points than those who had fluoroscopically-assisted surgery. The mean DASH scores were similar for both groups at 24 months, whereas the difference in the mean modified Mayo wrist scores remained statistically significant. Although the groups are small, it is clear that the addition of arthroscopy to the fluoroscopically-assisted treatment of intra-articular distal radius fractures improves the outcome. Better treatment of associated intra-articular injuries might also have been a reason for the improved outcome. PMID:18539672

  7. Extra-articular soft tissue ganglion cyst around the knee: focus on the associated findings

    International Nuclear Information System (INIS)

    The aim of this study was to evaluate MR imaging findings of the associated findings in surrounding tissues of the extra-articular soft tissue ganglion cysts around the knee. We retrospectively reviewed MR images of 30 patients who had surgically confirmed extra-articular soft tissue ganglion cysts around the knee with focus on the associated findings in surrounding tissues, such as muscle, subcutaneous fat, bone, and nerve. The most common associated finding was the visualization of channel between ganglion cyst and the joint, which was demonstrated in 20 cases (continuous type in 12 cases and discontinuous type in 8 cases). Other associated findings were seen in 15 cases; pericystic edema (n=9), bony remodelling (n=3), and nerve involvement (n=3). The bony remodelling involved the proximal metaphysis of tibia in all 3 cases. Two patients with nerve involvement had deep peroneal nerve in subacute phase and one involved common peroneal nerve in chronic phase. The MR imaging is a useful imaging modality to evaluate the associated findings in extra-articular soft tissue ganglion cysts around the knee. The evaluation of these associated findings is helpful for the differentiation of ganglion cysts from other cystic lesions around the knee. (orig.)

  8. Extra-articular soft tissue ganglion cyst around the knee: focus on the associated findings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jee-Young; Jung, Sun-Ah; Park, Young-Ha [Department of Radiology, St. Vincent' s Hospital, Catholic University of Korea, 93-6 Ji-dong, Paldal-ku, Suwon, 442-723, Kyounggi-do (Korea); Sung, Mi-Sook [Department of Radiology, Holy Family Hospital, Catholic University of Korea, Sosa-dong, Puchun (Korea); Kang, Yong-Koo [Department of Orthopedic Surgery, St. Vincent' s Hospital, Catholic University of Korea, 93-6 Ji-dong, Paldal-ku, Suwon, 442-723, Kyounggi-do (Korea)

    2004-01-01

    The aim of this study was to evaluate MR imaging findings of the associated findings in surrounding tissues of the extra-articular soft tissue ganglion cysts around the knee. We retrospectively reviewed MR images of 30 patients who had surgically confirmed extra-articular soft tissue ganglion cysts around the knee with focus on the associated findings in surrounding tissues, such as muscle, subcutaneous fat, bone, and nerve. The most common associated finding was the visualization of channel between ganglion cyst and the joint, which was demonstrated in 20 cases (continuous type in 12 cases and discontinuous type in 8 cases). Other associated findings were seen in 15 cases; pericystic edema (n=9), bony remodelling (n=3), and nerve involvement (n=3). The bony remodelling involved the proximal metaphysis of tibia in all 3 cases. Two patients with nerve involvement had deep peroneal nerve in subacute phase and one involved common peroneal nerve in chronic phase. The MR imaging is a useful imaging modality to evaluate the associated findings in extra-articular soft tissue ganglion cysts around the knee. The evaluation of these associated findings is helpful for the differentiation of ganglion cysts from other cystic lesions around the knee. (orig.)

  9. Intra-articular cysts and ganglia of the knee: a report of nine patients.

    Science.gov (United States)

    Sarimo, Janne; Rantanen, Jussi; Helttula, Ilmo; Orava, Sakari

    2005-01-01

    Completely intra-articular cysts and ganglia of the knee are rare. They have been found in various locations such as on the anterior or posterior cruciate ligaments, in the infrapatellar fat pad, on the posterior wall of the posteromedial compartment and (very rarely) in connection to the menisci. We analyzed nine patients with intra-articular cysts or ganglia found in a series of 2,400 consecutive arthroscopies. In four patients, the cyst or ganglion was found attached to the anterior part of the ACL, in two patients it was located between the ACL and the PCL, and in the remaining three cases it was found in connection with the meniscus. In three out of the nine patients there was either no or very minor additional pathology found in the knee besides the cyst or the ganglion. We believe that intra-articular cysts and ganglia of the knee can be symptomatic, and excellent or good results after cyst removal can be expected especially when there is little additional pathology. PMID:15654646

  10. Intra-articular ganglion cyst arising from the anterior cruciate ligament: a case report.

    Science.gov (United States)

    Peterson, J R; Frieman, B G; Kaplan, R H

    1996-01-01

    Intra-articular ganglion cysts have been reported in the medical literature but are extremely rare. A MEDLINE search from 1966 to July 1995 revealed no reported cases in the Physical Medicine literature. This case report details the presentation, evaluation and treatment course of a patient with knee complaints who was subsequently diagnosed to have a ganglion cyst arising from the anterior cruciate ligament. The patient was a 38-year-old woman with a 6-month history of knee swelling and pain. She had difficulty walking. Non-steroidal anti-inflammatory agents had not alleviated her symptoms significantly. Physiatric evaluation revealed a supra-patellar effusion and a mass lateral to the patellar tendon. MRI evaluation revealed an intra-articular cyst. The patient underwent surgical removal of what was subsequently determined to be an intra-articular ganglion cyst arising from the anterior cruciate ligament. The patient has had progressive resolution of her knee symptoms post-operatively. Physiatrists need to be aware of this cause of mechanical knee symptoms. PMID:24572556

  11. Analgesic effects of intra-articular fentanyl, pethidine and dexamethasone after knee arthroscopic surgery

    Directory of Open Access Journals (Sweden)

    H Saryazd

    2006-07-01

    Full Text Available BACKGROUND: Many different methods have been used in an effort to provide adequate analgesia after knee arthroscopic surgery. In this study analgesic effect of intra-articular fentanyl, pethidine and dexamethasone was compared. METHODS: In a double blind randomized study 48 male patients undergoing knee arthroscopic meniscectomy were allocated to groups receiving intra-articular fentanyl 50 µg or pethidine 20 mg or dexamethasone 8 mg at the end of arthroscopy during general aesthesia. Postoperative pain scores using visual analogue scale were measured and also analgesic requirements and the time of ability to walk were recorded. RESULTS: Pain scores at one, two, six and 24 h after intra-articular injection were not significantly different for fentanyl and pethidine but were higher significantly for dexamethasone at all four mentioned times. The mean average time of ability to walk was significantly longer for dexamethasone. The analgesic requirements during the first 24 h after intraarticular injection were significantly greater only for dexamethasone too. CONCLUSION: Better postoperative analgesia, less pain score and shorter time to walk were achieved by fentanyl and pethidine in comparison to dexamethasone but the results were not significantly different between fentanyl group and pethidine. KEYWORDS: Arthroscopy, opioid, pain.

  12. Analysis of friction between articular cartilage and polyvinyl alcohol hydrogel artificial cartilage.

    Science.gov (United States)

    Li, Feng; Wang, Anmin; Wang, Chengtao

    2016-05-01

    Many biomaterials are being used to repair damaged articular cartilage. In particular, poly vinyl alcohol hydrogel has similar mechanical properties to natural cartilage under compressive and shearing loading. Here, three-factor and two-level friction experiments and long-term tests were conducted to better evaluate its tribological properties. The friction coefficient between articular cartilage and the poly vinyl alcohol hydrogel depended primarily on the three factors of load, speed, and lubrication. When the speed increased from 10 to 20 mm/s under a load of 10 N, the friction coefficient increased from 0.12 to 0.147. When the lubricant was changed from Ringer's solution to a hyaluronic acid solution, the friction coefficient decreased to 0.084 with loads as high as 22 N. The poly vinyl alcohol hydrogel was severely damaged and lost its top surface layers, which were transferred to the articular cartilage surface. Wear was observed in the surface morphologies, which indicated the occurrence of surface adhesion of bovine cartilage. Surface fatigue and adhesive wear was the dominant wear mechanism. PMID:26970769

  13. Analgesic efficacy of intra-articular morphine after arthroscopic knee surgery in sport injury patients

    Directory of Open Access Journals (Sweden)

    Mitra Yari

    2013-07-01

    Full Text Available BACKGROUND: Anterior Cruciate Ligament (ACL tearing is a common injury among football players. The present study aims to determine the best single-dose of intra-articular morphine for pain relief after arthroscopic knee surgery that, in addition to adequate and long-term analgesia, leads to fewer systemic side effects. METHODS: This clinical trial was conducted on 40 ASA-I athletes. After surgery, all participants received an injection of 20cc of 0.5% intra-articular bupivacaine. In addition, the first control group received a saline injection and 5, 10 and 15 mg of morphine were respectively injected into the joints of the second, third and fourth groups by use of Arthroscopic equipment before the Arthroscopic removal. The amount of pain based on VAS at 1, 2, 4, 6 and 24 hours after surgery, duration of analgesia and the consumption of narcotic drugs were recorded. RESULTS: The VAS scores in the fourth, sixth and twenty-fourth hours after surgery showed a significant difference between the study groups. The average time to the first analgesic request from the bupivacaine plus 15 mg morphine group was significantly longer than other groups and total analgesic requests were significantly lower than other groups. No drowsiness complications were observed in any of the groups in the first 24 hours after injection. CONCLUSION: Application of 15 mg intra-articular morphine after Arthroscopic knee surgery increases the analgesia level as well as its duration (IRCT138902172946N3 .

  14. Growth differentiation factor-5 stimulates the growth and anabolic metabolism of articular chondrocytes

    Institute of Scientific and Technical Information of China (English)

    Xu Peng; Guo Xiong; Yao Jianfeng; Zhang Yingang; Klaus von der Mark

    2005-01-01

    Objective: To observe the effect of growth differentiation factor-5 (GDF-5) on the growth and anabolic metabolism of articular chondrocytes. Methods: The articular chondrocytes isolated from rats were treated with various concentrations of rmGDF-5, and the growth of chondrocytes measured by MTT assay, the cellular cartilage matrices formation detected sulfated glycosaminoglycan by Alcian blue staining and type Ⅱ collagen by RT-PCR,the collagen phenotypic expression of chondrocytes detected by immunofluorescence. Results: After 7 days culture,MTT assay showed that GDF-5 enhanced the growth of chondrocytes in a dose-dependent manner, RT-PCR showed that GDF-5 clearly induced the synthesis of type Ⅱ collagen because of the col2a1 mRNA band more and more strong in a dose-dependent. Chondrocytes were cultured with GDF-5 for 14 days, the intensity of Alcian blue staining was greatly enhanced, especially, at a high concentration of 1000ng/ml, and GDF-5 enhanced the accumulation of the Alcian blue-stainable material in a concentration-dependent manner and in a does-dependent manner. Chondrocytes were cultured with GDF-5 for 21 days, immunofluorescent staining of type Ⅱ collagen was clear, the type Ⅰ and X collagen were negative. Conclusion: GDF-5 enhanced the growth of mature articular chondrocytes, and stimulated the cellular cartilage matrices formation, but did not change the collagen phenotypic expression of chondrocytes in mono-layer culture.

  15. Growth Differentiation Factor-5 Stimulates the Growth and Anabolic Metabolism of Articular Chondrocytes

    Institute of Scientific and Technical Information of China (English)

    Xu Peng; Yao Jianfeng; Guo Xiong; Zhang Yingang; Klaus von der Mark

    2009-01-01

    Objective: To observe the effect of growth differentiation factor-5 (GDF-5) on the growth and anabolic metabolism of articular chondrocytes. Methods: The articular chondrocytes isolated from rats were treated with various concentrations of rmGDF-5, and the growth of chondrocytes measured by MTr assay, the cellular cartilage matrices formation detected sulfated glycosaminoglycan by Alcian blue staining and type 11 collagen by RT-PCR, the collagen phenotypic expression of chondrocytes detected by immunofluorescence. Results: After 7 days culture, MTF assay showed that GDF-5 enhanced the growth of ehondrocytes in a dose-dependent manner, RT-PCR showed that GDF-5 clearly induced the synthesis of type Ⅱ collagen because of the colal mRNA band more and more strong in a dose-dependent. Chondrocytes were cultured with GDF-5 for 14 days, the intensity of Alcian blue staining was gready enhanced, especially, at a high concentration of 1000ng/ml, and GDF-5 enhanced the accumulation of the Alcian blue-stainable material in a concentration-dependent manner and in a does-dependent manner. Chondrocytes were cultured with GDF-5 for 21 days, immunofluorescent staining of type Ⅱ collagen was clear, the type Ⅰ and Ⅹ collagen were negative. Conclusion: GDF-5 enhanced the growth of mature articular chon-drocytes, and stimulated the cellular cartilage matrices formation, but did not change the collagen phenotypic ex-pression of chondrocytes in mono-layer culture.

  16. Diffusion and near-equilibrium distribution of MRI and CT contrast agents in articular cartilage

    International Nuclear Information System (INIS)

    Charged contrast agents have been used both in vitro and in vivo for estimation of the fixed charge density (FCD) in articular cartilage. In the present study, the effects of molecular size and charge on the diffusion and equilibrium distribution of several magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents were investigated. Full thickness cartilage disks (Oe = 4.0 mm, n = 64) were prepared from fresh bovine patellae. Contrast agent (gadopentetate: Magnevist (registered) , gadodiamide: Omniscan(TM), ioxaglate: Hexabrix(TM) or sodium iodide: NaI) diffusion was allowed either through the articular surface or through the deep cartilage. CT imaging of the samples was conducted before contrast agent administration and after 1, 5, 9, 16, 25 and 29 h (and with three samples after 2, 3, 4 and 5 days) diffusion using a clinical peripheral quantitative computed tomography (pQCT) instrument. With all contrast agents, the diffusion through the deep cartilage was slower when compared to the diffusion through the articular surface. With ioxaglate, gadopentetate and gadodiamide it took over 29 h for diffusion to reach the near-equilibrium state. The slow diffusion of the contrast agents raise concerns regarding the validity of techniques for FCD estimation, as these contrast agents may not reach the equilibrium state that is assumed. However, since cartilage composition, i.e. deep versus superficial, had a significant effect on diffusion, imaging of the nonequilibrium diffusion process might enable more accurate assessment of cartilage integrity.

  17. Diffusion and near-equilibrium distribution of MRI and CT contrast agents in articular cartilage

    Energy Technology Data Exchange (ETDEWEB)

    Silvast, Tuomo S; Toeyraes, Juha [Department of Clinical Neurophysiology, Kuopio University Hospital, PO Box 1777, 70211 Kuopio (Finland); Kokkonen, Harri T; Jurvelin, Jukka S [Department of Physics, University of Kuopio, PO Box 1627, 70211 Kuopio (Finland); Quinn, Thomas M [Department of Chemical Engineering, McGill University, 3610 University Street, Montreal, Quebec H3A 2B2 (Canada); Nieminen, Miika T [Department of Diagnostic Radiology, Oulu University Hospital, PO Box 50, 90029, Oulu (Finland)], E-mail: Tuomo.Silvast@uku.fi

    2009-11-21

    Charged contrast agents have been used both in vitro and in vivo for estimation of the fixed charge density (FCD) in articular cartilage. In the present study, the effects of molecular size and charge on the diffusion and equilibrium distribution of several magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents were investigated. Full thickness cartilage disks (Oe = 4.0 mm, n = 64) were prepared from fresh bovine patellae. Contrast agent (gadopentetate: Magnevist (registered) , gadodiamide: Omniscan(TM), ioxaglate: Hexabrix(TM) or sodium iodide: NaI) diffusion was allowed either through the articular surface or through the deep cartilage. CT imaging of the samples was conducted before contrast agent administration and after 1, 5, 9, 16, 25 and 29 h (and with three samples after 2, 3, 4 and 5 days) diffusion using a clinical peripheral quantitative computed tomography (pQCT) instrument. With all contrast agents, the diffusion through the deep cartilage was slower when compared to the diffusion through the articular surface. With ioxaglate, gadopentetate and gadodiamide it took over 29 h for diffusion to reach the near-equilibrium state. The slow diffusion of the contrast agents raise concerns regarding the validity of techniques for FCD estimation, as these contrast agents may not reach the equilibrium state that is assumed. However, since cartilage composition, i.e. deep versus superficial, had a significant effect on diffusion, imaging of the nonequilibrium diffusion process might enable more accurate assessment of cartilage integrity.

  18. Diffusion and near-equilibrium distribution of MRI and CT contrast agents in articular cartilage.

    Science.gov (United States)

    Silvast, Tuomo S; Kokkonen, Harri T; Jurvelin, Jukka S; Quinn, Thomas M; Nieminen, Miika T; Töyräs, Juha

    2009-11-21

    Charged contrast agents have been used both in vitro and in vivo for estimation of the fixed charge density (FCD) in articular cartilage. In the present study, the effects of molecular size and charge on the diffusion and equilibrium distribution of several magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents were investigated. Full thickness cartilage disks (Ø = 4.0 mm, n = 64) were prepared from fresh bovine patellae. Contrast agent (gadopentetate: Magnevist((R)), gadodiamide: Omniscan, ioxaglate: Hexabrix or sodium iodide: NaI) diffusion was allowed either through the articular surface or through the deep cartilage. CT imaging of the samples was conducted before contrast agent administration and after 1, 5, 9, 16, 25 and 29 h (and with three samples after 2, 3, 4 and 5 days) diffusion using a clinical peripheral quantitative computed tomography (pQCT) instrument. With all contrast agents, the diffusion through the deep cartilage was slower when compared to the diffusion through the articular surface. With ioxaglate, gadopentetate and gadodiamide it took over 29 h for diffusion to reach the near-equilibrium state. The slow diffusion of the contrast agents raise concerns regarding the validity of techniques for FCD estimation, as these contrast agents may not reach the equilibrium state that is assumed. However, since cartilage composition, i.e. deep versus superficial, had a significant effect on diffusion, imaging of the nonequilibrium diffusion process might enable more accurate assessment of cartilage integrity. PMID:19864699

  19. Is Mandibular Fossa Morphology and Articular Eminence Inclination Associated with Temporomandibular Dysfunction?

    Science.gov (United States)

    Paknahad, Maryam; Shahidi, Shoaleh; Akhlaghian, Marzieh; Abolvardi, Masoud

    2016-01-01

    Statement of the Problem Finding a significant relationship between temporomandibular joint (TMJ) morphology and the incidence of temporomandibular dysfunction (TMD) may help early prediction and prevention of these problems. Purpose The purpose of the present study was to determine the morphology of mandibular fossa and the articular eminence inclination in patients with TMD and in control group using cone beam computed tomography (CBCT). Materials and Method The CBCT data of bilateral TMJs of 40 patients with TMD and 23 symptom-free cases were evaluated. The articular eminence inclination, as well as the glenoid fossa depth and width of the mandibular fossa were measured. The paired t-test was used to compare these values between two groups. Results The articular eminence inclination and glenoid fossa width and depth were significantly higher in patients with TMD than in the control group (p TMD than in the control group. Glenoid fossa width and depth were higher in patients with TMD than that in the control group. This information may shed light on the relationship between TMJ morphology and the incidence of TMD. PMID:27284559

  20. Deslumbramientos del mercado

    Directory of Open Access Journals (Sweden)

    Monique Selim

    2006-07-01

    Full Text Available Con eje en los diferentes aspectos que adopta el actual proceso de mundialización de la lógica del mercado y expansión capitalista, aún en países socialistas, el presente artículo plantea la necesidad de una reflexión antropológica susceptible de articular el surgimiento de nuevas formas de dominación y representación simbólicas. Se discute el aparente efecto de unificación intelectual producido por la hegemonía del mercado respecto de hechos sociales heterogéneos dados en la historia reciente de las sociedades contemporáneas. Así, la renovada atracción que ejercen los nuevos escenarios sociales reconfigurados en virtud de las modalidades específicas de encarnación y operación de los procesos globalizantes, llama al estudio antropológico de las coyunturas. La autora despliega una interpretación del socialismo de mercado, conjunción -siempre en tensión- de un monopolio político estatal y una liberalización del mercado económico. En esta perspectiva se reubica el interés de una antropología del presente en relevar localmente, en este caso en Vietnam del Norte, la conformación de un nuevo mercado de demandas simbólicas, donde la reaparición de las prácticas culturales de comunicación con los antepasados expresa la necesidad de reunificación familiar y reconciliación con los muertos en la "larga guerra".Tendo como eixo os aspectos diferentes que adota o processo atual de mundialização da lógica do mercado e de expansão capitalista, até mesmo nos países socialistas, este artigo propoe a necessidade de uma reflexão antropológica capaz de articular o aparecimento de novas formas de dominação e de representação simbólica. Discute-se o efeito de superfície de unificação intelectual causado pela hegemonia do mercado em fatos sociais diversos em sociedades contemporâneas. Assim, a atração renovada de novos fatos sociais pelos modos específicos de incorporação e operação de processos de globaliza

  1. LA LÓGICA DEL MERCADO Y EL COMPORTAMIENTO ÉTICO DE LA EMPRESA

    OpenAIRE

    Emmanuel Borgucci

    1999-01-01

    El presente ensayo tiene como finalidad abordar el concepto de la Responsabilidad social dela empresa y como está evolucionando en el transcurso del tiempo hasta desembocar en la obligación existencial de la empresa de articular relaciones que sobrepasan el paradigma de la simplicidad y que se aborde la interacción con la sociedad civil desde una perspectiva multidimensional. Sin embargo, desde la perspectiva de la lógica del mercado no es fácil que la empresa capte las permutaciones que los ...

  2. Hallazgo de una leucorrea vaginal de carácter no inflamatoria en hembras bovinas. III. Características clínicas y fertilidad (Finding of a vaginal leucorrhea of non-inflammatory character in bovine females. III.Clinical characteristics and fertility

    Directory of Open Access Journals (Sweden)

    Luis O. Alba Gómez

    2005-07-01

    Full Text Available El objetivo de este trabajo fue el de demostrar que la leucorrea vaginal no inflamatoria encontrada en algunas hembras bovinas, no afectaba su eficiencia reproductiva. Para esto se utilizaron 159 novillas y 474 vacas de los genotipos ¾ x ¼ y 5/8 x 3/8 Holstein x Cebú, incorporadas al programa de inseminación artificial. En el 13,8 y 10,5% de las novillas y vacas respectivamente se encontraron colecciones de seudoexudados muco-purulentos y purulentos en sus vaginas. Ninguna de las hembras utilizadas fue tratada antes ni después de ser inseminada. No se encontraron diferencias estadísticas entre las tasas de concepción de las hembras sin y con leucorrea vaginal (79,8 vs 81,8% y (75,0 vs 76,0% para las novillas y las vacas respectivamente. Se comprobó que este tipo de leucorrea vaginal bovina no inflamatoria no afecta la eficiencia reproductiva de esas hembras.

  3. In vitro of quantitative MR imaging of early degenerative changes in human articular cartilage

    International Nuclear Information System (INIS)

    To assess the applicability of quantitative MR microscopy for the detection of glycosaminoglycan (GAG) depletion as an early sign of degeneration in the articular cartilage of humans treated by trypsin. Four cartilage-bone blocks were obtained from the patient who had suffered from osteoarthritis of the knee and underwent a total knee replacement arthroscopy. Each articular cartilage segment was resected as to a round disk shape (8 mm in diameter) with a remnant of subchondral bone 1 mm in thickness. Four different culture solutions were prepared, and these solutions were 0.2 mg/ml of trypsin solution (group 1), 1 mM of Gd (DTPA) 2-mixed trypsin solution (group 2), phosphate buffered saline (PBS) (group 3), and 1 mM of Gd (DTPA) 2-mixed PBS (group 4). The cartilages were cultured and then MR imagings were performed every hour for 5 hrs, and we continued the additional cultures of 24 hrs, 36 hrs and 48 hrs. Three imaging sequences were used: T1-weighted spin echo (TR/TE, 450/22), proton density turbo spin echo with fat suppression (TR/TE, 3000/25), and CPMG (Carr-Purcell-Meiboom-Gill) (TR/TE/TI, 760/21-168, 360). MR imaging data were analyzed with pixel-by-pixel comparisons in all groups. The GAG loss in the articular cartilage was increased proportionately to the culture duration. Mean changes of T1 relaxation time were 1.2% for group 1, -1.9% for group 3, -54.7% for group 2 and -64.2% for group 4 (p< 0.05). When comparing by linear profile on the T1-weighted images, SNR increased and T1 relaxation time decreased for group 2 and 4, as the culture duration increased (p< 0.05). On the correlation analysis, there is significant correlation between GAG loss and Gd (DTPA) 2-enhancement for group 2 (p=0.0431), but there was no significant difference for group 4 (p=0.0918). More enhancement with Gd (DTPA) 2-was noted for group 2 than for group 4. Group 2 showed a diffuse enhancement in all the layers of cartilage, but for group 4, prominent enhancement was noted only in

  4. Efeitos do resfriamento e aquecimento articular no desempenho funcional do ombro

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    Dayane de Oliveira Estevam

    2015-06-01

    Full Text Available INTRODUÇÃO: Um dos recursos mais utilizados na reabilitação de lesões musculoesqueléticas é a termoterapia por subtração de calor (crioterapia, enquanto a termoterapia por adição de calor é considerada o procedimento mais antigo de reabilitação física. Entretanto, há poucas evidências que tenham investigado os efeitos desses recursos sobre o desempenho de membros superiores. OBJETIVO: Comparar o efeito do resfriamento e do aquecimento articular sobre o desempenho funcional do membro superior. MÉTODOS: Trinta e quatro voluntários (22,23 ± 2,17 anos; 22,39 ± 2,53 kg/m2, de ambos os sexos, foram divididos aleatoriamente em um dos três grupos: 1 grupo crioterapia GCR (n=10: submetidos ao resfriamento articular por compressas frias; 2 grupo termoterapia - GTE (n=10: submetidos ao aquecimento articular por ondas curtas e 3 grupo controle - GCO (n=14, não submetidos a qualquer intervenção. Os voluntários foram avaliados, pré e pós-intervenção, quanto ao desempenho funcional de membros superiores por meio dos testes de estabilidade da extremidade superior em cadeia cinética fechada (TEESCCF e das condições de equilíbrio em apoio bimanual sobre o baropodômetro. Ainda, os voluntários foram avaliados quanto ao desempenho funcional virtual por meio do jogo Mario Kart (Nintendo Wii (r . RESULTADOS: Houve melhora significativa nos valores pós-intervenção no TEESCCF para o GCR (p0,05. Entretanto, na condição de olhos fechados, houve piora de desempenho para GTE (p=0,04 e melhora de desempenho para o GCO (p=0,02. Não houve alteração significativa no desempenho funcional virtual para os três grupos (p>0,05. CONCLUSÃO: Embora não tenha favorecido o desempenho funcional em todos os testes reais e virtuais utilizados, o resfriamento articular foi mais efetivo que o aquecimento articular para manter o desempenho muscular do membro superior, especialmente nas condições de equilíbrio sobre membros superiores na condi

  5. Coeficiente de fricción y mecanismos de degradación superficial en materiales usados para la construcción de implantes de juntas articulares

    Directory of Open Access Journals (Sweden)

    Juan Alejandro Uribe A.

    2004-01-01

    Full Text Available El presente estudio evaluó los materiales más usados en nuestro medio para la fabricación de implantes de juntas articulares, evidenciando los mecanismos de deterioro superficial presentes en tres tribosistemas: a pin de acero AISI 316LVM contra un disco de acero AISI 316L, b pin de acero inoxidable AISI 316LVM contra disco de polietileno de ultra alto peso molecular (UHMWPE y c pin de una aleación Ti6Al4V contra disco de polietileno de ultra alto peso molecular (UHMWPE, con velocidad de deslizamiento de 0.58 m/s y diferentes cargas normales. Se adaptó una máquina de ensayos de desgaste normalizada del tipo pin – disco (norma ASTM G 99, de tal forma que permitiera sumergir el sistema en una solución de suero de sangre de bovino con una concentración de proteínas de 0.03 g/ml, la cual simula el ataque corrosivo al que se ven sometidos los materiales en las juntas implantadas dentro del cuerpo humano. Se midieron la variación de la fuerza y el coeficiente de fricción en el tiempo para estudiar el comportamiento del tribosistema, caracterizando las superficies desgastadas macro y microscópicamente con el fin de identificar los fenómenos de deterioro superficial. La adhesión fue el mecanismo predominante en el deslizamiento de los pares metal – polímero, mientras que la combinación de adhesión y abrasión fue responsable por un daño mucho mayor en el sistema metal-metal.

  6. Additive Effects of Intra-articular Injection of Growth Hormone and Hyaluronic Acid in Rabbit Model of Collagenase-induced Osteoarthritis

    OpenAIRE

    Kim, Sang Beom; Kwon, Dong Rak; Kwak, Hyun; Shin, Yong Beom; Han, Hyun-jung; Lee, Jong Hwa; Choi, Seok Hwa

    2010-01-01

    In a rabbit model of collagenase-induced osteoarthritis, the additive effects of intra-articular recombinant human growth hormone (GH) administration to hyaluronic acid (HA) were evaluated. After intra-articular collagenase injection, mature New Zealand white rabbits (n=30) were divided into 3 groups. Group 1 (control rabbits) received once weekly intra-articular saline injections for 4 weeks. Group 2 rabbits received 6 mg HA injections, and group 3 rabbits were injected with 6 mg HA and 3 mg...

  7. Intra-articular temperatures of the knee in sports – An in-vivo study of jogging and alpine skiing

    Directory of Open Access Journals (Sweden)

    Cerulli Guiliano

    2008-04-01

    Full Text Available Abstract Background Up to date, no information exists about the intra-articular temperature changes of the knee related to activity and ambient temperature. Methods In 6 healthy males, a probe for intra-articular measurement was inserted into the notch of the right knee. Each subject was jogging on a treadmill in a closed room at 19°C room temperature and skiing in a ski resort at -3°C outside temperature for 60 minutes. In both conditions, temperatures were measured every fifteen minutes intra-articulary and at the skin surface of the knee. A possible influence on joint function and laxity was evaluated before and after activity. Statistical analysis of intra-articular and skin temperatures was done using nonparametric Wilcoxon's sign rank sum test and Mann-Whitney's-U-Test. Results Median intra-articular temperatures increased from 31.4°C before activity by 2.1°C, 4°C, 5.8°C and 6.1°C after 15, 30, 45 and 60 min of jogging (all p ≤ 0.05. Median intra-articular temperatures dropped from 32.2°C before activity by 0.5°C, 1.9°C, 3.6°C and 1.1°C after 15, 30, 45 and 60 min of skiing (all n.s.. After 60 minutes of skiing (jogging, the median intra-articular temperature was 19.6% (8.7% higher than the skin surface temperature at the knee. Joint function and laxity appeared not to be different before and after activity within both groups. Conclusion This study demonstrates different changes of intra-articular and skin temperatures during sports in jogging and alpine skiing and suggests that changes are related to activity and ambient temperature.

  8. del Nim

    Directory of Open Access Journals (Sweden)

    Arturo Martínez Rodríguez

    2007-01-01

    Full Text Available Dado su uso específico como fuente de insecticidas naturales de fácil biodegradación, entre otras ventajas, el cultivo del árbol Nim ha sido mundialmente extendido en muchas regiones de Asia, África, Australia y América Latina, incluyendo Cuba. La cosecha del fruto del Nim se hace engorrosa debido a la altura que adquieren estos árboles a los pocos años de sembrados, siendo la cosecha mecánica mediante sacudidores de ramas o del tronco, una posible vía de solución práctica de esta problemática. En el presente trabajo se efectúa, mediante la simulación con el empleo de herramientas CAD-3D y programas de análisis por elementos finitos, un análisis modal abarcador de un número importante de modos de vibración del sistema fruto-pedúnculo del Nim. Como resultado del estudio se pudieron recomendar entornos de frecuencias de las vibraciones a aplicar con mejores expectativas durante la cosecha mecanizada de este producto.

  9. Assessment of range of motion and muscular shortening in female flamenco dancers. Valoración de las amplitudes articulares y acortamientos musculares en bailaoras de flamenco.

    Directory of Open Access Journals (Sweden)

    José L. Costa Sepúlveda

    2011-12-01

    Full Text Available The purpose of the study was to assess flexibility and range of motion in flamenco dancers of Cádiz, Sevilla and Jaén (Spain through a tests battery. The study population comprised 37 healthy flamenco dancers (25 ± 7,2 years, 1,6 ± 0,5 m y 56 ± 7,6 Kg. They performed a range of flexibility and motion tests (i.e. Kendall test, Nachlas test. Results has shown that there is muscle shortening in most of the tests that flamenco dancers has passed. We conclude that there are not many articles on physiological and fitness aspects of dance and we think that it is necessary a specific physical dancer training, to prevent injuries and to extend dancers life.El objetivo de este estudio es la valoración de la flexibilidad muscular y la amplitud articular en bailaoras de flamenco de la provincia de Cádiz, Sevilla y Jaén, a través de una batería de tests. En el estudio participaron 37 bailaoras de danza flamenca de 25 ± 7,2 años, con una altura con valores de 1,6 ± 0,5 m y 56 ± 7,6 Kg de peso. La batería está compuesta de las siguientes pruebas que se realizarán a través del protocolo de actuación especificado: Prueba de rotadores internos y aductores del hombro, Prueba de Kendall, Prueba de Diagonal Posterior, Prueba de Nachlas, Prueba de Ridge, Prueba de Flexión de cadera con rodilla en extensión, Prueba de Thomas y Prueba de Elongación de los flexores plantares. Los resultados demuestran que existen acortamientos en diferente musculatura implicada como los rotadores internos y aductores del hombro, dorsal ancho, pectoral mayor, redondo mayor, cintura escapular, psoas-ilíaco, recto anterior del muslo y sóleo. Concluir con la escasa existencia de artículos relacionados con la valoración de la condición física de bailarines de cualquier modalidad de danza y con la necesaria aplicación de un entrenamiento planificado complementario con una propuesta de ejercicios de mejora de la musculatura implicada y, así, poder prevenir futuras

  10. Hyaluronic acid-coated bovine serum albumin nanoparticles loaded with brucine as selective nanovectors for intra-articular injection

    Directory of Open Access Journals (Sweden)

    Chen Z

    2013-10-01

    Full Text Available Zhipeng Chen,* Juan Chen,* Li Wu, Weidong Li, Jun Chen, Haibo Cheng, Jinhuo Pan, Baochang CaiDepartment of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China*These authors contributed equally to this workObjective: To evaluate the potential of hyaluronic acid (HA-coated bovine serum albumin nanoparticles (BSANPs as a novel chondrocyte-targeting drug-delivery nanomedicine.Methods: The HA-BSANPs were characterized by dynamic light scattering, transmission electron microscopy, differential scanning calorimetry, and X-ray diffraction. Fluorescence imaging was used to visualize the distribution of nanoparticles after intra-articular injection. The chondrocyte-targeting efficiency and cellular uptake mechanism of HA-BSANPs were investigated using endocytic inhibitors.Results: HA-BSANPs were successfully prepared with HA coating the surface and amorphous drug in the core. Compared with BSANPs, HA-BSANPs exhibited improved uptake by chondrocytes through a receptor-mediated active uptake mechanism. The endocytosis process of BSANPs and HA-BSANPs involved clathrin-mediated endocytosis, caveolae-mediated endocytosis, and macropinocytosis. No apparent thickening or hyperplasia of the synovium was observed in either BSANPs or HA-BSANPs. The HA-BSANPs could reside in the articular cavity of rats for more than 14 days, which was significantly longer than BSANPs.Conclusion: HA-BSANPs are a promising carrier for articular-related diseases due to elongated articular residence and improved chondrocytic accumulation.Keywords: chondrocyte, intra-articular injection, hyaluronic acid, BSA, nanoparticles

  11. Morphological evidence of the shedding of chondrocytes from the articular surface in neonatal rats: relationship to the interlacunar network.

    Science.gov (United States)

    Cole, M B; Narine, K R; Ellinger, J

    1983-08-01

    The superficial zone of the femoral head articular cartilage of 5- to 15-day old rats was examined by light and electron microscopy for evidence of shedding into the joint space. Chondrocytes deepest in the superficial zone were round, surrounded by a capsule, and connected to adjacent chondrocytes by the interlacunar network, whereas cells in the middle of the zone appeared similar but with less cytoplasm. At the circular surface, chondrocytes were small, with pyknotic nuclei and poorly defined organelles. These cells occasionally protruded from the articular surface but maintained at least partial connection with the network and their capsule. Depressions in the articular surface were lined with material similar to that of the network and were the only locations found where the network did not terminate at a cell surface. This static evidence suggested at least two hypotheses: 1) Degenerating chondrocytes moved up through the superficial zone to the articular surface and were shed into the joint space. This movement may be facilitated by the network as part of neonatal cartilage development. 2) During joint formation, the surface of the articular cartilage was eroded down to the chondrocytes, which were exposed to the joint fluid, causing cell degeneration, death, and shedding. Evidence of cell shedding was rarely seen after 2 weeks of age. Likewise, the interlacunar network disappeared from the superficial zone during this period. A physiological as well as structural relationship may exist between the chondrocytes and interlacunar network. PMID:6625202

  12. The usefulness of Tc-99m-MDP bone scintigraphy in detection of articular involvement of Behcet's disease

    International Nuclear Information System (INIS)

    Articular involvement was reported to be present in approximately 5-76% of Behcet patients. Therefore, we need a useful non-invasive method to detect articular involvement early in Behcet patients with nonspecific complaints. We aimed to evaluate the usefulness of 99mTc-methylene diphosphonate (Tc-99m-MDP) bone scintigraphy in the detection of the articular involvement of Behcet's disease (BD). Bone scintigraphy with Tc-99m-MDP was performed in 32 (17 male, 15 female) consecutive patients with BD. The sacroiliac (SI) joints with SI index higher than 1.34 were diagnosed as having sacroiliitis. Although joint complaints were present in only 8 (25%) patients, we detected joint involvement by scintigraphy in 27/32 (84.4%) Behcet patients mostly affecting the knees (62.5%), ankles (59.4%), SI joints (25%), wrists (21.9%), shoulders (18.7%), elbows (12.5%) and hips (3.1%). The articular involvement was monoarticular in four cases (12.5%) and was oligoarticular in the remaining. There was no correlation between joint involvement and age, gender, disease duration, drug usage or other clinical manifestations. Despite the fact that our patients were clinically asymptomatic and had normal pelvis radiography, sacroiliitis was found in 8 patients (25%). Bone scintigraphy is sensitive in the diagnosis of joint involvement allowing earlier diagnosis and showing the presence of articular involvement, especially in SI joints. (author)

  13. The effects of proteoglycan and type II collagen on T1rho relaxation time of articular cartilage

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Won Seok; Yoo, Hye Jin; Hong, Sung Hwan; Choi, Ja Young [Dept. of Radiology and Institute of Radiation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2015-02-15

    To evaluate the effects of proteoglycan and type II collagen within articular cartilage on T1rho relaxation time of articular cartilage. This study was exempted by the institutional and animal review boards, and informed consent was not required. Twelve porcine patellae were assigned to three groups of control, trypsin-treated (proteoglycan-degraded), or collagenase-treated (collagen-degraded). The T1rho images were obtained with a 3 tesla magnetic resonance imaging scanner with a single loop coil. Statistical differences were detected by analysis of variance to evaluate the effects of the enzyme on T1rho relaxation time. Safranin-O was used to stain proteoglycan in the articular cartilage and immunohistochemical staining was performed for type II collagen. Mean T1rho values of the control, trypsin-treated, and collagenase-treated groups were 37.72 +/- 5.82, 57.53 +/- 8.24, and 45.08 +/- 5.31 msec, respectively (p < 0.001). Histology confirmed a loss of proteoglycan and type II collagen in the trypsin- and collagenase-treated groups. Degradation of proteoglycans and collagen fibers in the articular cartilage increased the articular cartilage T1rho value.

  14. Modulation of Apoptosis and Differentiation by the Treatment of Sulfasalazine in Rabbit Articular Chondrocytes

    Science.gov (United States)

    Lee, Won Kil; Kang, Jin Seok

    2016-01-01

    This study was conducted to examine the cellular regulatory mechanisms of sulfasalazine (SSZ) in rabbit articular chondrocytes treated with sodium nitroprusside (SNP). Cell phenotype was determined, and the MTT assay, Western blot analysis and immunofluorescence staining of type II collagen was performed in control, SNP-treated and SNP plus SSZ (50~200 μg/mL) rabbit articular chondrocytes. Cellular proliferation was decreased significantly in the SNP-treated group compared with that in the control (p < 0.01). SSZ treatment clearly increased the SNP-reduced proliferation levels in a concentration-dependent manner (p < 0.01). SNP treatment induced significant dedifferentiation and inflammation compared with control chondrocytes (p < 0.01). Type II collagen expression levels increased in a concentration-dependent manner in response to SSZ treatment but were unaltered in SNP-treated chondrocytes (p < 0.05 and < 0.01, respectively). Cylooxygenase-2 (COX-2) expression increased in a concentration-dependent manner in response to SSZ treatment but was unaltered in SNP-treated chondrocytes (p < 0.05). Immunofluorescence staining showed that SSZ treatment increased type II collagen expression compared with that in SNP-treated chondrocytes. Furthermore, phosphorylated extracellular regulated kinase (pERK) expression levels were decreased significantly in the SNP-treated group compared with those in control chondrocytes (p < 0.01). Expression levels of pERK increased in a concentration-dependent manner by SSZ but were unaltered in SNP-treated chondrocytes. pp38 kinase expression levels increased in a concentration-dependent manner by SSZ but were unaltered in control chondrocytes (p < 0.01). In summary, SSZ significantly inhibited nitric oxide-induced cell death and dedifferentiation, and regulated extracellular regulated kinases 1 and 2 and p38 kinase in rabbit articular chondrocytes. PMID:27123162

  15. Forearm articular proportions and the antebrachial index in Homo sapiens, Australopithecus afarensis and the great apes.

    Science.gov (United States)

    Williams, Frank L'Engle; Cunningham, Deborah L; Amaral, Lia Q

    2015-12-01

    When hominin bipedality evolved, the forearms were free to adopt nonlocomotor tasks which may have resulted in changes to the articular surfaces of the ulna and the relative lengths of the forearm bones. Similarly, sex differences in forearm proportions may be more likely to emerge in bipeds than in the great apes given the locomotor constraints in Gorilla, Pan and Pongo. To test these assumptions, ulnar articular proportions and the antebrachial index (radius length/ulna length) in Homo sapiens (n=51), Gorilla gorilla (n=88), Pan troglodytes (n=49), Pongo pygmaeus (n=36) and Australopithecus afarensis A.L. 288-1 and A.L. 438-1 are compared. Intercept-adjusted ratios are used to control for size and minimize the effects of allometry. Canonical scores axes show that the proximally broad and elongated trochlear notch with respect to size in H. sapiens and A. afarensis is largely distinct from G. gorilla, P. troglodytes and P. pygmaeus. A cluster analysis of scaled ulnar articular dimensions groups H. sapiens males with A.L. 438-1 ulna length estimates, while one A.L. 288-1 ulna length estimate groups with Pan and another clusters most closely with H. sapiens, G. gorilla and A.L. 438-1. The relatively low antebrachial index characterizing H. sapiens and non-outlier estimates of A.L. 288-1 and A.L. 438-1 differs from those of the great apes. Unique sex differences in H. sapiens suggest a link between bipedality and forearm functional morphology. PMID:26256651

  16. Articular cartilage echography as a criterion of the evolution of osteoarthritis of the knee.

    Science.gov (United States)

    Martino, F; Ettorre, G C; Patella, V; Macarini, L; Moretti, B; Pesce, V; Resta, L

    1993-01-01

    We propose a modification of the Aisen's technique by which precise reproducible measurements of articular cartilage thickness of the knee is possible. A group of 23 patients with severe osteoarthritis was studied by ultra-sound (US) before knee prosthesis surgery. Evaluation with US was performed by a real-time scanner with a 7.5 MHz linear probe with upper-patellar transverse scans tangent to the upper patellar pole at 90 degrees knee flexion. The cartilage thickness was measured within the weight-bearing area. After surgery, on the corresponding gross pathological specimen, US re-evaluation and histological measurements were made. Results of pre- and post-operative ultrasonography (US) data were compared with histological data and a good correlation between these measurements was found (p(t) > 10%). Preoperative measurements ranged from 2.4 to 0.3 mm. In order to obtain normal reference values of the articular cartilage within the weight-bearing area of the femoral trochlea for comparison, a group of 10 control subjects was also studied with US as above. The US data were then compared with computed tomography (arthro-CT) evaluations. No significant differences in mean values were found between the two imaging techniques (2.2 mm versus 2.3 mm for the lateral condyle and 2.3 versus 2.3 for the medial condyle, respectively). We conclude that ultra-sound measurement of articular cartilage thickness of femoral condyles is a sensitive and reproducible technique which permits early diagnosis and management of knee arthropathy and also quantification of cartilage damage. PMID:7995680

  17. Diagnóstico y propuesta para una gestión integral del riesgo en el Valle de Aburrá: red riesgos.

    OpenAIRE

    Aristizábal, Edier; VARGAS, RICHARD; Mesa Sánchez, Óscar José

    2008-01-01

    A partir del análisis de la situación organizacional de las diferentes instituciones en el Valle de Aburrá frente a la reducción de desastres y emergencias asociadas con los fenómenos de origen natural y antrópico, el Área Metropolitana del Valle de Aburrá, como autoridad ambiental y entidad planificadora, hace una propuesta que pretende articular todas las entidades, organizaciones e instituciones públicas y privadas hacia una gestión integral del riesgo, y la cual denominó: Red para la Gest...

  18. Diagnóstico y propuesta para una gestión integral del riesgo en el valle de aburra: red riesgos

    OpenAIRE

    ARISTIZÁBAL, EDIER; VARGAS, RICHARD

    2010-01-01

    A partir del análisis de la situación organizacional de las diferentes instituciones en el Valle de Aburrá frente a la reducción de desastres y emergencias asociadas con los fenómenos de origen natural y antrópico, el Área Metropolitana del Valle de Aburrá, como autoridad ambiental y entidad planificadora, hace una propuesta que pretende articular todas las entidades, organizaciones e instituciones públicas y privadas hacia una gestión integral del riesgo, y la cual denominó: Red para la Gest...

  19. Doença articular degenerativa da articulação temporomandibular

    OpenAIRE

    Carvalho, Joana Alexandra Alves de

    2009-01-01

    Monografia apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Medicina Dentária Este trabalho foi desenvolvido com o intuito de abordar diversas questões relacionadas com o desenvolvimento da Doença Articular Degenerativa (DAD) ao nível da Articulação Temporomandibular (ATM). Os eventos moleculares que estão na base da patogénese da DAD da ATM e as artralgias associadas são complexos. Modelos contemporâneos sugerem que excessivas ...

  20. Hypersensitivity to mechanical and intra-articular electrical stimuli in persons with painful temporomandibular joints

    DEFF Research Database (Denmark)

    Ayesh, Emad; Jensen, Troels Staehelin; Svensson, P

    2007-01-01

    This study tested whether persons with TMJ arthralgia have a modality-specific and site-specific hypersensitivity to somatosensory stimuli assessed by quantitative sensory tests (QST). Forty-three healthy persons and 20 with TMJ arthralgia participated. The QST consisted of: sensory and pain...... detection thresholds and summation threshold to intra-articular electrical stimulation, tactile and pin-prick sensitivity in the TMJ area, pressure-pain threshold and tolerance on the lateral side of the TMJ and on the finger. Persons with TMJ arthralgia had lower pain detection and summation thresholds (P...... pain measures. This study provides new evidence...

  1. The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography

    Science.gov (United States)

    Ugryumova, Nadya; Attenburrow, Don P.; Winlove, C. Peter; Matcher, Stephen J.

    2005-08-01

    Optical coherence tomography and polarization-sensitive optical coherence tomography images of equine articular cartilage are presented. Measurements were made on intact joint surfaces. Significant (e.g. × 2) variations in the intrinsic birefringence were found over spatial scales of a few millimetres, even on samples taken from young (18 month) animals that appeared visually homogeneous. A comparison of data obtained on a control tissue (equine flexor tendon) further suggests that significant variations in the orientation of the collagen fibres relative to the plane of the joint surface exist. Images of visually damaged cartilage tissue show characteristic features both in terms of the distribution of optical scatterers and of the birefringent components.

  2. Diagnostic radiology of the osteo-articular system. 3. rev. and enl. ed.

    International Nuclear Information System (INIS)

    The book on diagnostic radiology of the osteo-articular system includes the following chapters: (1) Acute trauma and chronic overstress: essentials; (2) Acute trauma and chronic overstress (according regions); (3) Infections of bones, bone joints and soft tissue; (4) Tumors and tumor-like lesions of bones, bone joints and soft tissue; (5) Bone marrow; (6) Skeleton necrosis; (7) Osteochondrosis; (8) Metabolic, hormone related and toxically induced osteopathy; (9) Constitutional skeleton and bone joint development disturbances; (1) Rheumatic diseases; (11) Different skeletal, bone joint and soft tissue diseases; (12) Interventional actions at the skeleton, soft tissue and bone joints; (13) Radiological imaging of skeleton and bone joints.

  3. Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism

    OpenAIRE

    de Andrés, María C.; Maneiro, Emilia; Martín, Miguel A.; Arenas, Joaquín; Francisco J Blanco

    2013-01-01

    Introduction The pathogenesis of osteoarthritis (OA) is characterized by the production of high amounts of nitric oxide (NO), as a consequence of up-regulation of chondrocyte-inducible nitric oxide synthase (iNOS) induced by inflammatory cytokines. NO donors represent a powerful tool for studying the role of NO in the cartilage in vitro. There is no consensus about NO effects on articular cartilage in part because the differences between the NO donors available. The aim of this work is to com...

  4. Sports Hernia and Extra-Articular Causes of Groin Pain in the Athlete.

    Science.gov (United States)

    Cohn, Randy M; Lerebours, Frantz; Strauss, Eric J

    2015-06-01

    Groin pain is a common complaint in athletes that use the musculature of the lower abdomen and proximal thigh. The complex anatomy of the groin region and broad differential diagnosis presents the sports medicine specialist with unique diagnostic and treatment challenges. Sports hernia, osteitis pubis, and adductor dysfunction are common extra-articular musculoskeletal causes of groin pain in athletes. The current paper reviews the pathogenesis, history and physical examination, imaging, non-operative treatment, surgical techniques, and outcomes for these conditions. Treatment algorithms are presented for management of patients with sports hernia, osteitis pubis, and adductor dysfunction. PMID:26517161

  5. An intra-articular ganglion cyst in a patient with juvenile idiopathic arthritis

    OpenAIRE

    Deng, Donna Y; Yee, Keolamau; Burkhalter, William; Okimoto, Kelley Chinen; Kon, Kevin; Kurahara, David K

    2014-01-01

    We report an intra-articular ganglion cyst (IAGC) presenting as knee pain and a mass in a patient with longstanding Juvenile Idiopathic Arthritis (JIA). We could not find a similar case of an IAGC occurring in the knee of JIA patients in the literature. IAGC may need to be included as a possibility in patients with inflammatory arthritis with new-onset knee pain, especially in those with a palpable mass. MRI was useful in distinguishing IAGC from more worrisome causes of a knee mass. Orthoped...

  6. The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography

    International Nuclear Information System (INIS)

    Optical coherence tomography and polarization-sensitive optical coherence tomography images of equine articular cartilage are presented. Measurements were made on intact joint surfaces. Significant (e.g. x 2) variations in the intrinsic birefringence were found over spatial scales of a few millimetres, even on samples taken from young (18 month) animals that appeared visually homogeneous. A comparison of data obtained on a control tissue (equine flexor tendon) further suggests that significant variations in the orientation of the collagen fibres relative to the plane of the joint surface exist. Images of visually damaged cartilage tissue show characteristic features both in terms of the distribution of optical scatterers and of the birefringent components

  7. Efeitos do resfriamento e aquecimento articular no desempenho funcional do ombro

    OpenAIRE

    Dayane de Oliveira Estevam; Marcelo Lima de Oliveira; Marcelo Lourenço da Silva; Leonardo César Carvalho; Daniel Ferreira Moreira Lobato

    2015-01-01

    INTRODUÇÃO: Um dos recursos mais utilizados na reabilitação de lesões musculoesqueléticas é a termoterapia por subtração de calor (crioterapia), enquanto a termoterapia por adição de calor é considerada o procedimento mais antigo de reabilitação física. Entretanto, há poucas evidências que tenham investigado os efeitos desses recursos sobre o desempenho de membros superiores. OBJETIVO: Comparar o efeito do resfriamento e do aquecimento articular sobre o desempenho funcional do membro superior...

  8. Potencial del agua del suelo

    OpenAIRE

    Bustamante Heliodoro

    2012-01-01

    La energía potencial del agua presenta diferencias de un punto del suelo a otro; esas diferencias son las que originan el movimiento del agua de acuerdo a la tendencia universal de la materia en el sentido de moverse de donde la energía potencial es mayor a donde dicha energía es menor. En el suelo el agua en consecuencia se mueve hacia donde su energía decrece hasta lograr su estado de equilibrio. Se desprende entonces que la cantidad de energía potencial absoluta contenida en el agua, no es...

  9. Location and incidence of localized juxta-articular demineralizations and erosions at the wrist in early rheumatoid arthritis

    International Nuclear Information System (INIS)

    In early rheumatoid arthritis the location and incidence of localized juxta-articular demineralizations and erosions were investigated at 53 points of the wrist. On the level of the metacarpal bases, the distal and proximal row of the carpal bones more changes are seen in the oblique vd. and the lateral view than in the dv. view. At the distal bones of the forearm more changes are seen at the radius than at the ulnar styloid. The most often changes at all occur at the volar middle third of the triquetrum in the oblique view and at the distal volar articular facet of the scaphoid in the lateral view. Close relations between localized juxta-articular demineralizations and erosions do not exist. If the early bone changes at the wrist in rheumatoid arthritis are to be detected additional oblique and lateral view are prerequisite. (orig.)

  10. CLINICAL OBSERVATION ON THE THERAPEUTIC EFFECT OF ACUPUNCTURE PLUS MANUAL REPOSITION FOR TREATMENT OF ACUTE LUMBAR VERTEBRAL ARTICULAR DYSKINESIA

    Institute of Scientific and Technical Information of China (English)

    骆钧梵

    2003-01-01

    Objective: To observe the therapeutic effect of acupuncture plus manual reposition for treatment of acute lumbar vertebral articular dyskinesia for choosing a better remedy. Methods: 66 cases of acute lumbar vertebral articular dyskinesia were randomly divided into acupuncture plus manual reposition group (treatment group, n= 33) and routine manual reposition group (control group, n = 33). Yaotong-point was punctured, when, the patient was asked to move his or her waist simultaneously. Results: After one session of treatment, of the two 33 cases in treatment and control groups, 28 (84.85%) and20 (60.61%) were cured, 4 (12.12%) and 9 (27.27%) were improved, and 1 (3.03%) and 4 (12.12%) failed in the treatment. The therapeutic effect of treatment group was significantly superior to that of control group ( P< 0.05). Conclusion: Acupuncture combined with manual reposition is apparently superior to simple routine manual reposition in relieving acute lumbar vertebral articular dyskinesia.

  11. FIFTH LUMBAR VERTEBRA ASSOCIATED WITH ABSENCE OF SPINOUS PROCESS, LAMINAE AND INFERIOR ARTICULAR PROCESSES. – CASE REPORT

    Directory of Open Access Journals (Sweden)

    Prathap Kumar

    2013-09-01

    Full Text Available Background: The vertebral disorders are the ones which lead to disability and lot of health problems. Since the lumbar part of the vertebral column is the main weight bearing and weight transmitting region, if there is a defective development, the area for muscle attachment and the strong bony structure for the transmission of weight would be missing leading to instability at an early age. In the present case dry and processed fifth lumbar vertebra, of unknown sex which presented the features with absence of spinous process, laminae and the inferior articular processes on both sides which were obtained for teaching the medical undergraduate students in M.S.Ramaiah Medical College, Bangalore. There was absence of spinous process, laminae and the inferior articular processes of fifth lumbar vertebra leading to a wide spina bifida with absence of laminae, inferior articular processes on both sides and spinous process of fifth lumbar vertebra which could be a developmental anomaly.

  12. Chondrogenic Differentiation of Human Adipose-Derived Stem Cells: A New Path in Articular Cartilage Defect Management?

    Directory of Open Access Journals (Sweden)

    Jan-Philipp Stromps

    2014-01-01

    Full Text Available According to data published by the Centers for Disease Control and Prevention, over 6 million people undergo a variety of medical procedures for the repair of articular cartilage defects in the U.S. each year. Trauma, tumor, and age-related degeneration can cause major defects in articular cartilage, which has a poor intrinsic capacity for healing. Therefore, there is substantial interest in the development of novel cartilage tissue engineering strategies to restore articular cartilage defects to a normal or prediseased state. Special attention has been paid to the expansion of chondrocytes, which produce and maintain the cartilaginous matrix in healthy cartilage. This review summarizes the current efforts to generate chondrocytes from adipose-derived stem cells (ASCs and provides an outlook on promising future strategies.

  13. An evaluation of MRI in the diagnosis of occult peri-articular bone injury of knee joint

    International Nuclear Information System (INIS)

    Objective: An evaluation of MRI in the diagnosis of occult peri-articular bone injury. Methods: Thirty-one patients, in total thirty-three joints, underwent radiography and MRI. MRI sequences included FSE T1WI, FSE T2WI, T2WI/SPIR, PDWI/SPIR and 3D/WATSc/FPE/T1WI. Results: Abnormities were found in thirty-three knee joints. Bone bruises were found in 20 knees, occult fractures in 8 and articular cartilage or osteochondral fractures in 5. T2WI/SPIR was successful in demonstrating the bone bruise. PDWI/SPIR provided good images of the occult fracture, while 3D/WATSc/FFE/T1WI was the best sequence to demonstrate the cartilage fracture. Conclusion: MRI provides vivid images of the peri-articular occult injury of knee. Various MRI sequences have respective advantages in differentiating the nature of occult lesions and should be combined in clinical application. (authors)

  14. Estudio del Helicobacter pylori en el Perú

    Directory of Open Access Journals (Sweden)

    Alberto Ramírez Ramos

    2002-10-01

    Full Text Available El presente es el resultado del trabajo que diversos investigadores realizaron sobre la infección del H. pylori en el Perú. Epidemiología: notamos que la infección se adquiere a edades tempranas de la vida, siendo probablemente la vía oral-fecal y por el agua la forma de transmisión más importante. La prevalencia de la infección por H. pylori en los niveles socioeconómicos bajos es la misma en la costa, sierra y selva, manteniéndose estacionaria, a diferencia de los niveles medio y alto donde está disminuyendo (fenómeno asociado a la disminución de úlcera péptica y adenocarcinoma de estómago No existe evidencia que permita afirmar que ciertas razas tienen mayor predisposición para adquirir la infección, pero se ha notificado que en la población de altura es más frecuente la prevalencia de gastritis crónica atrófica que en la que habita a nivel del mar. Microbiología, biología molecular y patología: las cepas del H. pylori predominantes en el Perú son similares a las de España y Europa, pero muy diferentes a las encontradas en China y Japón. La gastritis crónica superficial, gastritis crónica profunda y gastritis crónica atrófica son diferentes estadios evolutivos de la lesión inflamatoria producida por la bacteria en el estómago. Diagnóstico: la biopsia de estómago utilizando coloración con plata es el patrón de oro. La combinación de dos métodos también puede ser útil. Tratamiento: los esquemas triples producen erradicación mayor al 80% los esquemas dobles y la monoterapia son insuficientes: la tasa de recaída postratamiento es alta y la mayoría por una cepa diferente.

  15. Articular Cartilage Evaluation After TruFit Plug Implantation Analyzed by Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC)

    NARCIS (Netherlands)

    Bekkers, J.E.J.; Bartels, L.W.; Vincken, K.L.; Dhert, W.J.A.; Creemers, L.B.; Saris, D.B.F.

    2013-01-01

    Background: Quantitative MRI of articular cartilage has rapidly developed in recent years and provides the clinician with a noninvasive tool to determine the biological consequence of an intervention. Purpose: To evaluate the quality of intra-articular cartilage, using the dGEMRIC scanning techniqu

  16. A randomized controlled trial of nonoperative treatment versus open reduction and internal fixation for stable, displaced, partial articular fractures of the radial head: The RAMBO trial

    NARCIS (Netherlands)

    W. Bruinsma (Wendy); I.F. Kodde (Izaäk Frederik); R.-J. De Muinck Keizer (Robert-Jan); P. Kloen (Peter); A. Lindenhovius (Anneluuk); J.P.A.M. Vroemen (Jos); R. Haverlag (Robert); M.P.J. van den Bekerom (Michel); H.W. Bolhuis (Hugo); P. Bullens (Pieter); S.A.G. Meylaerts (Sven); P. van der Zwaal (Peer); E.P. Steller; G.S. Hageman (Gregory); D. Ring (David); D. den Hartog (Dennis); E.R. Hammacher (Eric); G. King (Graham); G. Athwal (George); K. Faber (Ken); D. Drosdowech (Darren); R. Grewal (Ruby); J.C. Goslings (Carel); N.W.L. Schep (Niels); D. Eygendaal (Denise)

    2014-01-01

    textabstractBackground: The choice between operative or nonoperative treatment is questioned for partial articular fractures of the radial head that have at least 2 millimeters of articular step-off on at least one radiograph (defined as displaced), but less than 2 millimeter of gap between the frag

  17. Exploring reasons for the observed inconsistent trial reports on intra-articular injections with hyaluronic acid in the treatment of osteoarthritis

    DEFF Research Database (Denmark)

    Johansen, Mette; Bahrt, Henriette; Altman, Roy D;

    2016-01-01

    OBJECTIVE: The aim was to identify factors explaining inconsistent observations concerning the efficacy of intra-articular hyaluronic acid compared to intra-articular sham/control, or non-intervention control, in patients with symptomatic osteoarthritis, based on randomized clinical trials (RCTs)...

  18. Assessment of Intraoperative Intra-articular Morphine and Clonidine Injection in the Acute Postoperative Period After Hip Arthroscopy

    Science.gov (United States)

    Cogan, Charles J.; Knesek, Michael; Tjong, Vehniah K.; Nair, Rueben; Kahlenberg, Cynthia; Dunne, Kevin F.; Kendall, Mark C.; Terry, Michael A.

    2016-01-01

    Background: Previous authors have suggested that intra-articular morphine and clonidine injections after knee arthroscopy have demonstrated equivocal analgesic effect in comparison with bupivacaine while circumventing the issue of chondrotoxicity. There have been no studies evaluating the effect of intra-articular morphine after hip arthroscopy. Purpose: To evaluate the efficacy of intra-articular morphine in combination with clonidine on postoperative pain and narcotic consumption after hip arthroscopy surgery for femoroacetabular impingement. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective chart review was performed on 43 patients that underwent hip arthroscopy for femoroacetabular impingement at a single institution between September 2014 and May 2015. All patients received preoperative celecoxib and acetaminophen, and 22 patients received an additional intra-articular injection of 10 mg morphine and 100 μg of clonidine at the conclusion of the procedure. Narcotic consumption, duration of anesthesia recovery, and perioperative pain scores were compared between the 2 groups. Results: Patients who received intra-articular morphine and clonidine used significantly less opioid analgesic (mEq) in the postanesthesia recovery (median difference, 17 mEq [95% CI, –32 to –2 mEq]; P = .02) compared with the control group. There were no differences in time spent in recovery before hospital discharge or in visual analog pain scores recorded immediately postoperatively and at 1 hour after surgery. Conclusion: Intraoperative intra-articular injection of morphine and clonidine significantly reduced the narcotic requirement during the postsurgical recovery period after hip arthroscopy. The reduction in postsurgical opioids may decrease adverse effects, improve overall pain management, and lead to better quality of recovery and improved patient satisfaction. PMID:26977421

  19. Problemas de Sociología del Deporte

    Directory of Open Access Journals (Sweden)

    Rodolfo Iuliano

    2011-11-01

    Full Text Available El presente artículo es una apuesta por reconstruir, articular y problematizar los aportes y los avances de investigación en torno a los estudios sociales del deporte y el tiempo libre, puestos en discusiones en el marco de la mesa de trabajo sobre problemáticas de la sociología del deporte, llevada a cabo durante el 9no Congreso Argentino y 4to Latinoamericano de Educación Física y Ciencias. La lectura holística e integral de las diferentes producciones académicas, y los diálogos que de ellas se derivaron son puestos en cuestión y en relación a partir de la formulación de tres ejes problemáticos en torno a los cuales se estructura el presente artículo: la violencia y su relación con el fenómeno deportivo en los entramados sociales contemporáneos, las vinculaciones histórico sociales entre políticas públicas y deporte y, por último, el modo en que se articulan y en que resulta posible articular la relación entre los fenómenos deportivos y las ciencias sociales. Poner de relieve, sistematizar y problematizar los argumentos de los diferentes trabajos e investigaciones discutidos es el camino por el cual el presente artículo aspira a contribuir al estado actual de discusión sobre los estudios sociales del deporte y del tiempo libre

  20. Study of the collagen structure in the superficial zone and physiological state of articular cartilage using a 3D confocal imaging technique

    Directory of Open Access Journals (Sweden)

    Zheng Ming H

    2008-07-01

    Full Text Available Abstract Introduction The collagen structure in the superficial zone of articular cartilage is critical to the tissue's durability. Early osteoarthritis is often characterized with fissures on the articular surface. This is closely related to the disruption of the collagen network. However, the traditional histology can not offer visualization of the collagen structure in articular cartilage because it uses conventional optical microscopy that does not have insufficient imaging resolution to resolve collagen from proteoglycans in hyaline articular cartilage. This study examines the 3D collagen network of articular cartilage scored from 0 to 2 in the scoring system of International Cartilage Repair Society, and aims to develop a 3D histology for assessing early osteoarthritis. Methods Articular cartilage was visually classified into five physiological groups: normal cartilage, aged cartilage, cartilage with artificial and natural surface disruption, and fibrillated. The 3D collagen matrix of the cartilage was acquired using a 3D imaging technique developed previously. Traditional histology was followed to grade the physiological status of the cartilage in the scoring system of International Cartilage Repair Society. Results Normal articular cartilage contains interwoven collagen bundles near the articular surface, approximately within the lamina splendens. However, its collagen fibres in the superficial zone orient predominantly in a direction spatially oblique to the articular surface. With age and disruption of the articular surface, the interwoven collagen bundles are gradually disappeared, and obliquely oriented collagen fibres change to align predominantly in a direction spatially perpendicular to the articular surface. Disruption of the articular surface is well related to the disappearance of the interwoven collagen bundles. Conclusion A 3D histology has been developed to supplement the traditional histology and study the subtle changes in

  1. Intra-articular fibroma of tendon sheath in a knee joint associated with iliotibial band friction syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Dong Ho; Choi, Sun Seob; Kim, Soo Jin; Lih, Wang [Dong-A University Medical Center, Busan (Korea, Republic of)

    2015-02-15

    Iliotibial band (ITB) friction syndrome is a common overuse injury typically seen in the active athlete population. A nodular lesion on the inner side of the ITB as an etiology or an accompanying lesion from friction syndrome has been rarely reported. A 45-year-old male presented with recurrent pain and a movable nodule at the lateral joint area, diagnosed as ITB friction syndrome. The nodule was confirmed as a rare intra-articular fibroma of the tendon sheath (FTS) on the basis of histopathologic findings. We describe the MRI findings, arthroscopic and pathologic features, in this case of intra-articular FTS presenting with ITB friction syndrome.

  2. Intra-articular fibroma of tendon sheath in a knee joint associated with iliotibial band friction syndrome

    International Nuclear Information System (INIS)

    Iliotibial band (ITB) friction syndrome is a common overuse injury typically seen in the active athlete population. A nodular lesion on the inner side of the ITB as an etiology or an accompanying lesion from friction syndrome has been rarely reported. A 45-year-old male presented with recurrent pain and a movable nodule at the lateral joint area, diagnosed as ITB friction syndrome. The nodule was confirmed as a rare intra-articular fibroma of the tendon sheath (FTS) on the basis of histopathologic findings. We describe the MRI findings, arthroscopic and pathologic features, in this case of intra-articular FTS presenting with ITB friction syndrome.

  3. Expression of Transient Receptor Potential Vanilloid (TRPV Channels in Different Passages of Articular Chondrocytes

    Directory of Open Access Journals (Sweden)

    Richard Barrett-Jolley

    2012-04-01

    Full Text Available Ion channels play important roles in chondrocyte mechanotransduction. The transient receptor potential vanilloid (TRPV subfamily of ion channels consists of six members. TRPV1-4 are temperature sensitive calcium-permeable, relatively non-selective cation channels whereas TRPV5 and TRPV6 show high selectivity for calcium over other cations. In this study we investigated the effect of time in culture and passage number on the expression of TRPV4, TRPV5 and TRPV6 in articular chondrocytes isolated from equine metacarpophalangeal joints. Polyclonal antibodies raised against TRPV4, TRPV5 and TRPV6 were used to compare the expression of these channels in lysates from first expansion chondrocytes (P0 and cells from passages 1–3 (P1, P2 and P3 by western blotting. TRPV4, TRPV5 and TRPV6 were expressed in all passages examined. Immunohistochemistry and immunofluorescence confirmed the presence of these channels in sections of formalin fixed articular cartilage and monolayer cultures of methanol fixed P2 chondrocytes. TRPV5 and TRPV6 were upregulated with time and passage in culture suggesting that a shift in the phenotype of the cells in monolayer culture alters the expression of these channels. In conclusion, several TRPV channels are likely to be involved in calcium signaling and homeostasis in chondrocytes.

  4. Infecton is not specific for bacterial osteo-articular infective pathology

    Energy Technology Data Exchange (ETDEWEB)

    Dumarey, Nicolas; Blocklet, Didier; Schoutens, Andre [Division of Nuclear Medicine, Universite Libre de Bruxelles, Brussels (Belgium); Appelboom, Thierry; Tant, Laure [Division of Rheumatology, Universite Libre de Bruxelles, Brussels (Belgium)

    2002-04-01

    The aim of this study was to re-examine, by retrospective analysis of our case material, the specificity and sensitivity of technetium-99m ciprofloxacin scan in discriminating between infection and other conditions. {sup 99m}Tc-ciprofloxacin scintigraphy was performed in 71 patients: 30 patients referred for suspicion of osteomyelitis (OM) or septic arthritis (SA) (group 1) and 41 controls (group 2). Imaging was performed at 4 h post injection and, when possible, at 8 or 24 h post injection. Tracer uptake was visually assessed in different joint groups, and in the sites suspicious for infection. Several soft tissue sites were also evaluated. In the group referred for osteo-articular infection, we found a lower specificity (54.5%) than has previously been reported in the literature. Evaluation of tracer uptake at late imaging did not improve discrimination between sterile and non-sterile inflammation. Additionally, articular uptake was seen in many control patients. Infecton uptake in growth cartilage, thyroid gland, vascular pool, lungs, liver and intestines is discussed. (orig.)

  5. Pulsed CO2 laser for intra-articular cartilage vaporization and subchondral bone perforation in horses

    Science.gov (United States)

    Nixon, Alan J.; Roth, Jerry E.; Krook, Lennart P.

    1991-05-01

    A pulsed carbon dioxide laser was used to vaporize articular cartilage in four horses, and perforate the cartilage and subchondral bone in four horses. Both intercarpal joints were examined arthroscopically and either a 1 cm cartilage crater or a series of holes was created in the third carpal bone of one joint. The contralateral carpus served as a control. The horses were evaluated clinically for 8 weeks, euthanatized and the joints examined radiographically, grossly, and histologically. Pulsed carbon dioxide laser vaporized cartilage readily but penetrated bone poorly. Cartilage vaporization resulted in no greater swelling, heat, pain on flexion, lameness, or synovial fluid reaction than the sham procedure. Laser drilling resulted in a shallow, charred hole with a tenacious carbon residue, and in combination with the thermal damage to deeper bone, resulted in increased swelling, mild lameness and a low-grade, but persistent synovitis. Cartilage removal by laser vaporization resulted in rapid regrowth with fibrous and fibrovascular tissue and occasional regions of fibrocartilage at week 8. The subchondral bone, synovial membrane, and draining lymph nodes appeared essentially unaffected by the laser cartilage vaporization procedure. Conversely, carbon dioxide laser drilling of subchondral bone resulted in poor penetration, extensive areas of thermal necrosis of bone, and significant secondary damage to the apposing articular surface of the radial carpal bone. The carbon dioxide laser is a useful intraarticular instrument for removal of cartilage and has potential application in inaccessible regions of diarthrodial joints. It does not penetrate bone sufficiently to have application in subchondral drilling.

  6. Chondrocytes, Mesenchymal Stem Cells, and Their Combination in Articular Cartilage Regenerative Medicine.

    Science.gov (United States)

    Nazempour, A; Van Wie, B J

    2016-05-01

    Articular cartilage (AC) is a highly organized connective tissue lining, covering the ends of bones within articulating joints. Its highly ordered structure is essential for stable motion and provides a frictionless surface easing load transfer. AC is vulnerable to lesions and, because it is aneural and avascular, it has limited self-repair potential which often leads to osteoarthritis. To date, no fully successful treatment for osteoarthritis has been reported. Thus, the development of innovative therapeutic approaches is desperately needed. Autologous chondrocyte implantation, the only cell-based surgical intervention approved in the United States for treating cartilage defects, has limitations because of de-differentiation of articular chondrocytes (AChs) upon in vitro expansion. De-differentiation can be abated if initial populations of AChs are co-cultured with mesenchymal stem cells (MSCs), which not only undergo chondrogenesis themselves but also support chondrocyte vitality. In this review we summarize studies utilizing AChs, non-AChs, and MSCs and compare associated outcomes. Moreover, a comprehensive set of recent human studies using chondrocytes to direct MSC differentiation, MSCs to support chondrocyte re-differentiation and proliferation in co-culture environments, and exploratory animal intra- and inter-species studies are systematically reviewed and discussed in an innovative manner allowing side-by-side comparisons of protocols and outcomes. Finally, a comprehensive set of recommendations are made for future studies. PMID:26987846

  7. Effects of friction on the unconfined compressive response of articular cartilage: a finite element analysis.

    Science.gov (United States)

    Spilker, R L; Suh, J K; Mow, V C

    1990-05-01

    A finite element analysis is used to study a previously unresolved issue of the effects of platen-specimen friction on the response of the unconfined compression test; effects of platen permeability are also determined. The finite element formulation is based on the linear KLM biphasic model for articular cartilage and other hydrated soft tissues. A Galerkin weighted residual method is applied to both the solid phase and the fluid phase, and the continuity equation for the intrinsically incompressible binary mixture is introduced via a penalty method. The solid phase displacements and fluid phase velocities are interpolated for each element in terms of unknown nodal values, producing a system of first order differential equations which are solved using a standard numerical finite difference technique. An axisymmetric element of quadrilateral cross-section is developed and applied to the mechanical test problem of a cylindrical specimen of soft tissue in unconfined compression. These studies show that interfacial friction plays a major role in the unconfined compression response of articular cartilage specimens with small thickness to diameter ratios. PMID:2345443

  8. Zn deposition at the bone cartilage interface in equine articular cartilage

    Science.gov (United States)

    Bradley, D. A.; Moger, C. J.; Winlove, C. P.

    2007-09-01

    In articular cartilage metalloproteinases, a family of enzymes whose function relies on the presence of divalent cations such as Zn and Ca plays a central role in the normal processes of growth and remodelling and in the degenerative and inflammatory processes of arthritis. Another important enzyme, alkaline phosphatase, involved in cartilage mineralisation also relies on metallic cofactors. The local concentration of divalent cations is therefore of considerable interest in cartilage pathophysiology and several authors have used synchrotron X-ray fluorescence (XRF) to map metal ion distributions in bone and cartilage. We report use of a bench-top XRF analytical microscope, providing spatial resolution of 10 μm and applicable to histological sections, facilitating correlation of the distribution with structural features. The study seeks to establish the elemental distribution in normal tissue as a precursor to investigation of changes in disease. For six samples prepared from equine metacarpophalangeal joint, we observed increased concentration of Zn and Sr ions around the tidemark between normal and mineralised cartilage. This is believed to be an active site of remodelling but its composition has hitherto lacked detailed characterization. We also report preliminary results on two of the samples using Proton-Induced X-ray Emission (PIXE). This confirms our previous observations using synchrotron-based XRF of enhanced deposition of Sr and Zn at the surface of the subchondral bone and in articular cartilage.

  9. 3D Hydrogel Scaffolds for Articular Chondrocyte Culture and Cartilage Generation.

    Science.gov (United States)

    Smeriglio, Piera; Lai, Janice H; Yang, Fan; Bhutani, Nidhi

    2015-01-01

    Human articular cartilage is highly susceptible to damage and has limited self-repair and regeneration potential. Cell-based strategies to engineer cartilage tissue offer a promising solution to repair articular cartilage. To select the optimal cell source for tissue repair, it is important to develop an appropriate culture platform to systematically examine the biological and biomechanical differences in the tissue-engineered cartilage by different cell sources. Here we applied a three-dimensional (3D) biomimetic hydrogel culture platform to systematically examine cartilage regeneration potential of juvenile, adult, and osteoarthritic (OA) chondrocytes. The 3D biomimetic hydrogel consisted of synthetic component poly(ethylene glycol) and bioactive component chondroitin sulfate, which provides a physiologically relevant microenvironment for in vitro culture of chondrocytes. In addition, the scaffold may be potentially used for cell delivery for cartilage repair in vivo. Cartilage tissue engineered in the scaffold can be evaluated using quantitative gene expression, immunofluorescence staining, biochemical assays, and mechanical testing. Utilizing these outcomes, we were able to characterize the differential regenerative potential of chondrocytes of varying age, both at the gene expression level and in the biochemical and biomechanical properties of the engineered cartilage tissue. The 3D culture model could be applied to investigate the molecular and functional differences among chondrocytes and progenitor cells from different stages of normal or aberrant development. PMID:26484414

  10. Study on the Microstructure of Human Articular Cartilage/Bone Interface

    Institute of Scientific and Technical Information of China (English)

    Yaxiong Liu; Qin Lian; Jiankang He; Jinna Zhao; Zhongmin Jin; Dichen Li

    2011-01-01

    For improving the theory of gradient microstructure of cartilage/bone interface, human distal femurs were studied. Scanning Electron Microscope (SEM), histological sections and MicroCT were used to observe, measure and model the microstructure of cartilage/bone interface. The results showed that the cartilage/bone interface is in a hierarchical structure which is composed of four different tissue layers. The interlocking of hyaline cartilage and calcified cartilage and that of calcified cartilage and subchondral bone are in the manner of"protrusion-pore" with average diameter of 17.0 μm and 34.1 μm respectively. In addition, the cancellous bone under the cartilage is also formed by four layer hierarchical structure, and the adjacent layers are connected by bone trabecula in the shape of H, I and Y, forming a complex interwoven network structure. Finally, the simplified structure model of the cartilage/bone interface was proposed according to the natural articular cartilage/bone interface. The simplified model is a 4-layer gradient biomimetic structure, which corresponds to four different tissues of natural cartilage/bone interface. The results of this work would be beneficial to the design of bionic scaffold for the tissue engineering of articular cartilage/bone.

  11. Mesenchymal stem cells as a potent cell source for articular cartilage regeneration

    Institute of Scientific and Technical Information of China (English)

    Mohamadreza; Baghaban; Eslaminejad; Elham; Malakooty; Poor

    2014-01-01

    Since articular cartilage possesses only a weak capac-ity for repair, its regeneration potential is considered one of the most important challenges for orthopedic surgeons. The treatment options, such as marrow stimulation techniques, fail to induce a repair tissue with the same functional and mechanical properties of native hyaline cartilage. Osteochondral transplantation is considered an effective treatment option but is as-sociated with some disadvantages, including donor-site morbidity, tissue supply limitation, unsuitable mechani-cal properties and thickness of the obtained tissue. Although autologous chondrocyte implantation results in reasonable repair, it requires a two-step surgical pro-cedure. Moreover, chondrocytes expanded in culture gradually undergo dedifferentiation, so lose morpho-logical features and specialized functions. In the search for alternative cells, scientists have found mesenchymal stem cells(MSCs) to be an appropriate cellular mate-rial for articular cartilage repair. These cells were origi-nally isolated from bone marrow samples and further investigations have revealed the presence of the cells in many other tissues. Furthermore, chondrogenic dif-ferentiation is an inherent property of MSCs noticedat the time of the cell discovery. MSCs are known to exhibit homing potential to the damaged site at which they differentiate into the tissue cells or secrete a wide spectrum of bioactive factors with regenerative proper-ties. Moreover, these cells possess a considerable im-munomodulatory potential that make them the general donor for therapeutic applications. All of these topics will be discussed in this review.

  12. Ongoing studies of cell-based therapies for articular cartilage defects in Japan

    Directory of Open Access Journals (Sweden)

    Ogura T

    2014-12-01

    Full Text Available Takahiro Ogura,1 Akihiro Tsuchiya,2 Shuichi Mizuno1 1Department of Orthopedic Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; 2Funabashi Orthopaedic Hospital Sports Medicine Center, Funabashi, Chiba, Japan Abstract: Recently, cell-based therapies have generated great interest in the repair of articular cartilage defects and degeneration. Surgical treatments for these indications have multiple options, including marrow stimulation, osteochondral autograft transplant, and autologous chondrocyte implantation. The autologous chondrocyte implantation technique has been improved using a cell scaffold and other devices. Meanwhile, advanced cell-based therapies, including cultured stem cell treatment, have been studied in clinical trials. Most studies have been designed and authorized by institutional review boards and/or the regulatory agencies of the investigators’ countries. For cellular products in regenerative medicine, regulations of many countries are amenable to expedited approval. This paper aims to provide an update on ongoing and prospective cell-based therapies, focusing on articular cartilage injury at designated institutions authorized by the Japanese Pharmaceutical and Medical Device Agency. Keywords: autologous chondrocyte implantation, mesenchymal stem cell, knee joint

  13. Intra-articular use of hyaluronic acid in the treatment of osteoarthritis

    Directory of Open Access Journals (Sweden)

    Alberto Migliore

    2008-06-01

    Full Text Available Alberto Migliore1,2, Mauro Granata31UOS of Rheumatology S. Pietro Fatebenefratelli Hospital, Rome, Italy; 2AFaR Research Center, S. Pietro, Rome, Italy; 3UOS of Rheumatology S. Filippo Neri Hospital, Rome, ItalyAbstract: Osteoarthritis is one of the leading causes of disability in the elderly. The changes in the lubricating properties of synovial fluid lead to significant pain and loss of function. More than ten years have passed from the first studies. Up till now many authors have supported intra-articular hyaluronan (HA therapy as not only a symptom-modifying therapy but also a treatment which may significantly decrease the rate of deterioration of joint structure. In this review we report data relative to knee and hip treatment. The ongoing studies continue to further our understanding of the fundamental mechanisms that likely underlie the therapeutic benefits of this treatment but, despite recent progress, many unresolved issues require further study. Large scale double blind controlled studies must be carried out to confirm these promising data and produce meaningful guidelines.Keywords: osteoarthritis, hyaluronan, intra-articular injections, ultrasound-guided, viscosupplementation

  14. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

    Science.gov (United States)

    Lee, Whasil; Leddy, Holly A.; Chen, Yong; Lee, Suk Hee; Zelenski, Nicole A.; McNulty, Amy L.; Wu, Jason; Beicker, Kellie N.; Coles, Jeffrey; Zauscher, Stefan; Grandl, Jörg; Sachs, Frederick; Liedtke, Wolfgang B.

    2014-01-01

    Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities in response to mechanical loading. Pathological mechanical stress can lead to maladaptive cellular responses and subsequent cartilage degeneration. We sought to deconstruct chondrocyte mechanotransduction by identifying mechanosensitive ion channels functioning at injurious levels of strain. We detected robust expression of the recently identified mechanosensitive channels, PIEZO1 and PIEZO2. Combined directed expression of Piezo1 and -2 sustained potentiated mechanically induced Ca2+ signals and electrical currents compared with single-Piezo expression. In primary articular chondrocytes, mechanically evoked Ca2+ transients produced by atomic force microscopy were inhibited by GsMTx4, a PIEZO-blocking peptide, and by Piezo1- or Piezo2-specific siRNA. We complemented the cellular approach with an explant-cartilage injury model. GsMTx4 reduced chondrocyte death after mechanical injury, suggesting a possible therapy for reducing cartilage injury and posttraumatic osteoarthritis by attenuating Piezo-mediated cartilage mechanotransduction of injurious strains. PMID:25385580

  15. Deginerative changes of femoral articular cartilage in the knee : comparative study of specimen sonography and pathology

    International Nuclear Information System (INIS)

    To determine the sonographic findings of degenerative change in femoral articular cartilage of the knee by comparative study of specimen sonography and pathology. We obtained 40 specimens of cartilage of the femur (20 medial and 20 lateral condylar) from 20 patients with osteoarthritis of the knee who had undergone total knee replacement. The specimens were placed in a saline-filled container and sonography was performed using a 10-MHz linear transducer. Sonographic abnormalities were evaluated at the cartilage surface, within the cartilage, and at the bone-cartilage interface, and were compared with the corresponding pathologic findings. In addition, cartilage thickness was measured at a representative portion of each femoral cartilage specimen and was compared with the thickness determined by sonography. 'Dot' lesions, irregularity or loss of the hyperechoic line, were demonstrated by sonography at the saline-cartilage interface of 14 cartilages. Pathologic examination showed that these findings corresponded to cleft, detachment, erosion, and degeneration. Irregularities in the hyperechoic line at the bone-cartilage interface were revealed by sonography in eight cartilages and were related to irregularity or loss of tidemark, downward displacement of the cartilage, and subchondral callus formation. Dot lesions, corresponding to cleft and degeneration, were noted within one cartilage. Cartilage thickness measured on specimen and by sonography showed no significant difference (p=0.446). Specimen sonography suggested that articular cartilage underwent degenerative histopathological change. Cartilage thickness measured by sonography exactly reflected real thickness

  16. Infecton is not specific for bacterial osteo-articular infective pathology

    International Nuclear Information System (INIS)

    The aim of this study was to re-examine, by retrospective analysis of our case material, the specificity and sensitivity of technetium-99m ciprofloxacin scan in discriminating between infection and other conditions. 99mTc-ciprofloxacin scintigraphy was performed in 71 patients: 30 patients referred for suspicion of osteomyelitis (OM) or septic arthritis (SA) (group 1) and 41 controls (group 2). Imaging was performed at 4 h post injection and, when possible, at 8 or 24 h post injection. Tracer uptake was visually assessed in different joint groups, and in the sites suspicious for infection. Several soft tissue sites were also evaluated. In the group referred for osteo-articular infection, we found a lower specificity (54.5%) than has previously been reported in the literature. Evaluation of tracer uptake at late imaging did not improve discrimination between sterile and non-sterile inflammation. Additionally, articular uptake was seen in many control patients. Infecton uptake in growth cartilage, thyroid gland, vascular pool, lungs, liver and intestines is discussed. (orig.)

  17. Zn deposition at the bone-cartilage interface in equine articular cartilage

    Energy Technology Data Exchange (ETDEWEB)

    Bradley, D.A. [Department of Physics, University of Surrey, Guildford, GU2 7XH (United Kingdom)], E-mail: D.A.Bradley@surrey.ac.uk; Moger, C.J.; Winlove, C.P. [School of Physics, University of Exeter, Exeter, EX4 4QL (United Kingdom)

    2007-09-21

    In articular cartilage metalloproteinases, a family of enzymes whose function relies on the presence of divalent cations such as Zn and Ca plays a central role in the normal processes of growth and remodelling and in the degenerative and inflammatory processes of arthritis. Another important enzyme, alkaline phosphatase, involved in cartilage mineralisation also relies on metallic cofactors. The local concentration of divalent cations is therefore of considerable interest in cartilage pathophysiology and several authors have used synchrotron X-ray fluorescence (XRF) to map metal ion distributions in bone and cartilage. We report use of a bench-top XRF analytical microscope, providing spatial resolution of 10 {mu}m and applicable to histological sections, facilitating correlation of the distribution with structural features. The study seeks to establish the elemental distribution in normal tissue as a precursor to investigation of changes in disease. For six samples prepared from equine metacarpophalangeal joint, we observed increased concentration of Zn and Sr ions around the tidemark between normal and mineralised cartilage. This is believed to be an active site of remodelling but its composition has hitherto lacked detailed characterization. We also report preliminary results on two of the samples using Proton-Induced X-ray Emission (PIXE). This confirms our previous observations using synchrotron-based XRF of enhanced deposition of Sr and Zn at the surface of the subchondral bone and in articular cartilage.

  18. Zn deposition at the bone-cartilage interface in equine articular cartilage

    International Nuclear Information System (INIS)

    In articular cartilage metalloproteinases, a family of enzymes whose function relies on the presence of divalent cations such as Zn and Ca plays a central role in the normal processes of growth and remodelling and in the degenerative and inflammatory processes of arthritis. Another important enzyme, alkaline phosphatase, involved in cartilage mineralisation also relies on metallic cofactors. The local concentration of divalent cations is therefore of considerable interest in cartilage pathophysiology and several authors have used synchrotron X-ray fluorescence (XRF) to map metal ion distributions in bone and cartilage. We report use of a bench-top XRF analytical microscope, providing spatial resolution of 10 μm and applicable to histological sections, facilitating correlation of the distribution with structural features. The study seeks to establish the elemental distribution in normal tissue as a precursor to investigation of changes in disease. For six samples prepared from equine metacarpophalangeal joint, we observed increased concentration of Zn and Sr ions around the tidemark between normal and mineralised cartilage. This is believed to be an active site of remodelling but its composition has hitherto lacked detailed characterization. We also report preliminary results on two of the samples using Proton-Induced X-ray Emission (PIXE). This confirms our previous observations using synchrotron-based XRF of enhanced deposition of Sr and Zn at the surface of the subchondral bone and in articular cartilage

  19. Qualidade de vida de pacientes portadores de doença inflamatória intestinal Calidad de vida de pacientes portadores de enfermedad inflamatoria intestinal Quality of life of patients with inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    Mardem Machado de Souza

    2011-01-01

    Full Text Available OBJETIVOS: Avaliar a qualidade de vida (QV de portadores de doenças inflamatórias intestinais (DII e relacionar dados sociodemográficos e mórbidos à QV. MÉTODOS: Estudo transversal, realizado com 103 portadores de DII, cadastrados na farmácia de alto custo de Cuiabá - Mato Grosso que responderam ao Prontuário-Padrão, ao questionário de QV geral SF36 e ao específico IBDQ. RESULTADOS: Dentre os 103 pacientes com DII, 62 tinham retocolite ulcerativa idiopática e 41 doença de Crohn; 62% eram mulheres; 69,9%, casados; 48,5%, pardos; 49,5%, fumantes, 37,9% necessitaram de cirurgia e 40,8% apresentavam doença em atividade. Foi observada alteração significativa da QV em homens, fumantes e entre aqueles com doença em atividade. CONCLUSÃO: DII afetam a QV em diversos aspectos. Medidas para manutenção da QV, suporte psicológico, social e educacional devem ser considerados para portadores de DII.OBJETIVOS: Evaluar la calidad de vida (CV de portadores de enfermedades inflamatorias intestinales (EII y relacionar datos sociodemográficos y mórbidos a la CV. MÉTODOS: Se trata de un estudio transversal, realizado con 103 portadores de EII, registrados en la farmacia de alto costo de Cuiabá - Mato Grosso que respondieron a la Historia Clínica-Patrón, al cuestionario de CV general SF36 y al específico IBDQ. RESULTADOS: De los 103 pacientes con EII, 62 tenían rectocolitis ulcerosa idiopática y 41 enfermedad de Crohn; 62% eran mujeres; 69,9%, casados; 48,5%, pardos; 49,5%, fumadores, 37,9% necesitaron de cirugía y 40,8% presentaban la enfermedad en actividad. Fue observada una alteración significativa de la CV en hombres, fumadores y en aquellos con la enfermedad en actividad. CONCLUSIÓN: Las EII afectan la CV en diversos aspectos. Para la manutención de la CV, deben ser considerados el soporte psicológico, social y educacional de los portadores de EII.OBJECTIVES: To assess the quality of life (QV in patients with inflammatory

  20. Competencias emocionales en el proceso de formación del docente de Educación Infantil

    OpenAIRE

    Pegalajar Palomino, María del Carmen; López Hernáez, Lara

    2015-01-01

    El proceso de formación inicial del docente debe plantear el desarrollo de competencias emocionales, pues resultan cruciales para dotar de calidad la enseñanza del sistema educativo. De este modo, se deben articular acciones tendentes a facilitar el desarrollo de habilidades para que el docente tome consciencia de sí mismo, a la vez que maneje y reconozca tanto sus emociones y motivaciones como las de los otros. Esta investigación pretende evaluar el nivel de autorrealización y crecimiento pe...

  1. What lies beneath: sub-articular long bone shape scaling in eutherian mammals and saurischian dinosaurs suggests different locomotor adaptations for gigantism.

    Directory of Open Access Journals (Sweden)

    Matthew F Bonnan

    Full Text Available Eutherian mammals and saurischian dinosaurs both evolved lineages of huge terrestrial herbivores. Although significantly more saurischian dinosaurs were giants than eutherians, the long bones of both taxa scale similarly and suggest that locomotion was dynamically similar. However, articular cartilage is thin in eutherian mammals but thick in saurischian dinosaurs, differences that could have contributed to, or limited, how frequently gigantism evolved. Therefore, we tested the hypothesis that sub-articular bone, which supports the articular cartilage, changes shape in different ways between terrestrial mammals and dinosaurs with increasing size. Our sample consisted of giant mammal and reptile taxa (i.e., elephants, rhinos, sauropods plus erect and non-erect outgroups with thin and thick articular cartilage. Our results show that eutherian mammal sub-articular shape becomes narrow with well-defined surface features as size increases. In contrast, this region in saurischian dinosaurs expands and remains gently convex with increasing size. Similar trends were observed in non-erect outgroup taxa (monotremes, alligators, showing that the trends we report are posture-independent. These differences support our hypothesis that sub-articular shape scales differently between eutherian mammals and saurischian dinosaurs. Our results show that articular cartilage thickness and sub-articular shape are correlated. In mammals, joints become ever more congruent and thinner with increasing size, whereas archosaur joints remained both congruent and thick, especially in sauropods. We suggest that gigantism occurs less frequently in mammals, in part, because joints composed of thin articular cartilage can only become so congruent before stress cannot be effectively alleviated. In contrast, frequent gigantism in saurischian dinosaurs may be explained, in part, by joints with thick articular cartilage that can deform across large areas with increasing load.

  2. Efecto de la movilización articular sobre la amplitud del Reflejo H en personas con espasticidad

    Directory of Open Access Journals (Sweden)

    Julio Ernesto Pérez Parra

    2011-08-01

    Full Text Available Objective: To determine the effect of ankle joint mobilization on the H reflex amplitude of the soleus muscle in people with spasticity. Materials and methods: A quasi-experimental study with crossover design and simple masking was conducted in 24 randomized subjects to initiate the control or experimental group. Traction and rhythmic oscillation were applied for five minutes to the ankle joint. H wave amplitude changes of Hoffmann reflex (electrical equivalent of the monosynaptic spinal reflex was assessed, stimulating the tibial nerve at the level of the popliteal fossa and recording in the soleusmuscle. In each subject 12 measurements were taken: basalrate, during and after mobilization. Changes in H reflex amplitudewere calculated in relation to basal measurement. For each measurement a hypothesis test was performed (Student t test. Results: In groups of patients with brain injury and incomplete spinal cord injury, a significant difference was found between measurements of both studies, concerning variation in H reflex amplitude during the application of joint mobilization techniques, with a decrease in the experimental group and an increase in the control group. In contrast, no significant differences were found after mobilization therapy. Patients with complete spinal cord injuryshowed no significant differences in any measurements. Conclusion: Wedemonstrate the effectiveness of joint mobilization in the decreaseof H reflex amplitude in patients with brain injury or incompletespinal cord injury during the mobilization maneuver, but no residualeffect after completion of the trial. This research showed noevidence regarding excitability reduction in complete spinal cordinjury. We suggest that therapeutic interventions to decrease muscletone based on the joint mobilization should be reconsidered.

  3. Efecto de la movilización articular sobre la amplitud del Reflejo H en personas con espasticidad

    OpenAIRE

    Julio Ernesto Pérez Parra; Claudia Patricia Henao Lema

    2011-01-01

    Objective: To determine the effect of ankle joint mobilization on the H reflex amplitude of the soleus muscle in people with spasticity. Materials and methods: A quasi-experimental study with crossover design and simple masking was conducted in 24 randomized subjects to initiate the control or experimental group. Traction and rhythmic oscillation were applied for five minutes to the ankle joint. H wave amplitude changes of Hoffmann reflex (electrical equivalent of the monosynaptic spinal refl...

  4. Culturas del Mundo

    DEFF Research Database (Denmark)

    Benwell, Ann Fenger; Costa, Alberto; Waehle, Espen

    2006-01-01

    ’Culturas del mundo. Colecciones del Museo Nacional de Dinamarca’ with Ann Fenger Benwell in Culturas del Mundo. Colecciones del Museo Nacional de Dinamarca, ed. Silvia Sauquet, Fundación "la Caixa", Barcelona 2006, pp. 31-39......’Culturas del mundo. Colecciones del Museo Nacional de Dinamarca’ with Ann Fenger Benwell in Culturas del Mundo. Colecciones del Museo Nacional de Dinamarca, ed. Silvia Sauquet, Fundación "la Caixa", Barcelona 2006, pp. 31-39...

  5. Analgesia intra-articular com morfina, bupivacaína ou fentanil após operação de joelho por videoartroscopia Analgesia intra-articular con morfina, bupivacaína o fentanil después de operación de rodilla por videoartroscopia Intra-articular analgesia with morphine, bupivacaine or fentanyl after knee video-arthroscopy surgery

    Directory of Open Access Journals (Sweden)

    Rogério Helcias de Souza

    2002-09-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: O uso de métodos que promovam analgesia para dor do joelho sem prejudicar a função motora tem sido bastante pesquisado. O objetivo do presente estudo foi comparar o efeito analgésico da morfina, da bupivacaína e do fentanil, com a solução fisiológica, injetada por via intra-articular após operação de joelho por videoartroscopia. MÉTODO: Sessenta pacientes foram divididos de forma aleatória, em quatro grupos: GI (n=15 - 10 ml de solução fisiológica; GII (n = 15 - 2 mg de morfina diluídos para 10 ml de solução fisiológica; GIII (n = 15 - 10 ml de bupivacaína a 0,25%; GIV (n = 15 - 100 µg de fentanil diluídos para 10 ml de solução fisiológica, injetados ao término da operação. Todos os pacientes foram submetidos à anestesia subaracnóidea com 15 mg de bupivacaína hiperbárica. A intensidade da dor foi avaliada pela escala analógica visual (imediatamente após o término da operação e após 6, 12, 18 e 24 horas, bem como a necessidade de complementação analgésica (dipirona 1 g por via venosa. Foram anotados os possíveis efeitos colaterais. RESULTADOS: Não houve diferença significativa na intensidade da dor entre os grupos, na quase totalidade dos tempos estudados. Houve diferença estatística até seis horas, quando o grupo fentanil apresentou intensidade da dor significativamente menor. O grupo morfina necessitou de maior número de complementações com dipirona. Os efeitos colaterais foram mínimos, sem significância estatística. CONCLUSÕES: Não houve diferença significativa entre a analgesia promovida pelas soluções estudadas na maioria dos tempos investigados.JUSTIFICATIVA Y OBJETIVOS: El uso de métodos que promuevan analgesia para el dolor de rodilla sin perjudicar la función motora ha sido bastante pesquisado. El objetivo del presente estudio fue comparar el efecto analgésico de la morfina, de la bupivacaína y del fentanil, con la solución fisiológica, inyectada

  6. Comparison of MR arthrography with arthroscopy of the hip for the assessment of intra-articular loose bodies

    International Nuclear Information System (INIS)

    To assess the specificity and sensitivity of MR arthrography of the hip in comparison with arthroscopy for the evaluation of intra-articular loose bodies. Over a 3-year period, 81 consecutive patients underwent a total of 82 hip arthroscopies by a single orthopedic surgeon for intractable hip pain. Of the 82 arthroscopies, 70 had pre-operative MR arthrograms. Of these, 57 were available for retrospective review, after which they were compared with the operative notes of the subsequent arthroscopies. Of 82 arthroscopies 16 (20%) demonstrated intra-articular loose bodies, while, in the study group, nine of 57 had loose bodies (16%). There was a total of seven discordant cases (five false negatives and two false positives). The sensitivity of MR arthrography for detection of intra-articular loose bodies was 44%, while the specificity was 96%. While the specificity of MR arthrography for the detection of intra-articular loose bodies was high (96%), the sensitivity was not nearly as good (44%). (orig.)

  7. Clinical Trial and In Vitro Study for the Role of Cartilage and Synovia in Acute Articular Infection

    DEFF Research Database (Denmark)

    Langenmair, E. R.; Kubosch, E. J.; Salzmann, G. M.;

    2015-01-01

    Objective. Osteoarthritis is a long-term complication of acute articular infections. However, the roles of cartilage and synovia in this process are not yet fully understood. Methods. Patients with acute joint infections were enrolled in a prospective clinical trial and the cytokine composition o...

  8. Variation in viscoelastic properties of bovine articular cartilage below, up to and above healthy gait-relevant loading frequencies

    OpenAIRE

    Sadeghi, Hamid; Espino, Daniel M; Shepherd, Duncan ET

    2015-01-01

    The aim of this study was to determine the variation in viscoelastic properties of femoral head bovine articular cartilage, on-bone, over five orders of magnitude of loading frequency. These frequencies ranged from below, up to and above healthy gait-relevant frequencies, using

  9. Intracapsular and para- articular chondroma of knee. A report of four cases and review of the literature

    International Nuclear Information System (INIS)

    Background. Intracapsular and para-articular chondroma is a rare variant of the extraskeletal chondromas. It arises from the capsule and/or the para-articular connective tissue of the large joints (mostly the knee) and is a result of cartilaginous metaplasia. In course of time these tumors ossify and this is where their second name comes from: Para-articular osteochondromas. According to Jaffe, not dependent on the degree of ossification of this tumor, there is one single entity in question. Cases report. We report four new cases of para-articular chondroma of the knee. On physical examination there was slow-growing solid mass in the knee and moderate pain, the radiological findings and CT scan show soft-tissue mass with variable amount of ossification, and on histological examination the presence of mature hyaline and connective cartilage was confirmed in all of the cases. Conclusions. The diagnosis of these benign tumors is made with correlation of clinical, radiological and histological features. The treatment of choice is surgical excision in toto. (author)

  10. Intra-articular Ganglion Cyst of the Long Head of the Biceps Tendon Originating from the Intertubercular Groove

    OpenAIRE

    hossein saremi; Alireza Yavarikia; Ali karbalaikhani

    2014-01-01

    Ganglion cysts commonly occur around the shoulder, mostly in the spinoglenoid and suprascapular notches. We report a very rare case of intra articular Ganglion cyst of the long head of the biceps tendon that originated from the bicipital groove as a rare cause of shoulder pain.

  11. Intra-articular Ganglion Cyst of the Long Head of the Biceps Tendon Originating from the Intertubercular Groove

    Directory of Open Access Journals (Sweden)

    hossein saremi

    2014-09-01

    Full Text Available Ganglion cysts commonly occur around the shoulder, mostly in the spinoglenoid and suprascapular notches. We report a very rare case of intra articular Ganglion cyst of the long head of the biceps tendon that originated from the bicipital groove as a rare cause of shoulder pain.

  12. PKCa Agonists Enhance the Protective Effect of Hyaluronic Acid on Nitric Oxide-Induced Apoptosis of Articular Chondrocytes in Vitro

    Directory of Open Access Journals (Sweden)

    Jian-lin Zhou

    2013-12-01

    The results may be showed that PKCa regulate the expresion of caspase-3, which contribute to the apoptosis of chondrocytes induced by NO. PKC α agonists enhance the protective effect of hyaluronic acid on nitric oxide-induced articular chondrocytes apoptosis.

  13. Electrostatic and Non-Electrostatic Contributions of Proteoglycans to the Compressive Equilibrium Modulus of Bovine Articular Cartilage

    OpenAIRE

    Guterl, Clare Canal; Hung, Clark T.; Ateshian, Gerard A.

    2010-01-01

    This study presents direct experimental evidence for assessing the electrostatic and nonelectrostatic contributions of proteoglycans to the compressive equilibrium modulus of bovine articular cartilage. Immature and mature bovine cartilage samples were tested in unconfined compression and their depth-dependent equilibrium compressive modulus was determined using strain measurements with digital image correlation analysis. The electrostatic contribution was assessed by testing samples in isoto...

  14. Papel de la proteína quinasa dependiente de cGMP (PKG) y de la c-Src tirosina quinasa en la regulación antagónica del óxido nítrico sobre la apoptosis

    OpenAIRE

    Tejedo Huamán, Juan Rigoberto

    2000-01-01

    En los últimos años se han acumulado evidencias concernientes al papel de la apoptosis en el control de la población de células beta en la patogénesis de la IDDM. Así se ha visto que la apoptosis en células beta de roedores está mediada por la generación de óxido nítrico (NO) en un proceso regulado por citoquinas inflamatorias. Sin embargo respecto al papel del NO en el control de la apoptosis se han encontrado varios mecanismos por los que altas concentraciones de NO la inducen y bajas conce...

  15. Intra-articular methotrexate associated to lipid nanoemulsions: anti-inflammatory effect upon antigen-induced arthritis

    Directory of Open Access Journals (Sweden)

    Mello SB

    2013-02-01

    Full Text Available Suzana BV Mello,1 Elaine R Tavares,2 Adriana Bulgarelli,2 Eloisa Bonfá,1 Raul C Maranhão2,31Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; 2Lipid Metabolism Laboratory, the Heart Institute (INCOR of the Medical School Hospital, São Paulo, Brazil; 3Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, BrazilObjective: Commercial methotrexate formulations (MTX have poor anti-inflammatory action for intra-articular treatment of rheumatoid arthritis. Our aim was to investigate whether an association between methotrexate and lipidic nanoemulsions (LDE could improve MTX intra-articular action.Methods: For its association to LDE, MTX was previously esterified with dodecyl bromide. LDE-MTX was prepared by high pressure homogenization. Antigen-induced arthritis (AIA was achieved in rabbits sensitized with methylated bovine serum albumin, and the rabbits were subsequently intra-articularly injected with the antigen. Twenty-four hours after AIA induction, groups of four to nine rabbits were intra-articularly injected with increasing doses (0.0625–0.5 µmol/kg of LDE-MTX, and were compared to treatment with 0.5 µmol/kg commercial MTX, LDE alone, and saline (controls. Synovial fluid was collected 48 hours after AIA induction for analysis of protein leakage and cell content. Synovial membranes were collected for histopathology. Uptake of LDE labeled with 3H-cholesteryl ether by the synovial tissue was also determined.Results: Uptake of radioactive LDE by arthritic joints was 2.5-fold greater than by normal joints. Treatment with intra-articular LDE-MTX elicited a clear dose response pattern by reducing the synovial leukocyte infiltrate (P = 0.004 and protein leakage (P = 0.032 when compared with arthritic non-treated joints. In contrast, the intra-articular injection of commercial MTX and LDE did not reduce leukocyte infiltrate or protein leakage. Toxicity to treatment was not observed

  16. Integrity of articular cartilage on T2 mapping associated with meniscal signal change

    International Nuclear Information System (INIS)

    Objective: The purpose of this study was to investigate the relationship between T2 relaxation values (T2 RVs) within the superficial zone of articular cartilage and different types of meniscal degeneration/tear. Materials and methods: A review of 310 consecutive knee MRIs which included an 8 echo T2 relaxation sequence, in patients referred for standard clinical indications, was performed independently and in blinded fashion by 2 observers. The posterior horns of the medial and lateral menisci were each evaluated and divided into 4 subgroups: Normal (control), Grade I/II meniscal signal, Grade III meniscal signal-simple tear (Grade III-S), and Grade III meniscal signal-complex tear (Grade III-C). After exclusion criteria were applied, the medial meniscal group consisted of 65 controls and 133 patients, while the lateral meniscal group consisted of 143 controls and 55 patients. T2 RVs were measured by an observer blinded to the clinical history and MRI grading. Measurements were obtained over the superficial zone of femoral and tibial articular cartilage adjacent to the center of the posterior horn of each meniscus to ensure consistency between measurements. Analysis of covariance adjusting for age and gender was used to compare T2 RVs between patients and controls. Results: T2 RVs were significantly increased in patients with Grade III-C meniscal tears compared to controls over the medial tibial plateau (MTP; p = 0.0001) and lateral tibial plateau (LTP; p = 0.0008). T2 RVs were not increased in patients with Grade III-C meniscal tears over the medial femoral condyle (MFC; p = 0.11) or lateral femoral condyle (LFC; p = 0.99). Grade I/II meniscal signal was not associated with elevated T2 RVs over the MFC (p = 0.15), LFC (p = 0.69), MTP (p = 0.42), or LTP (p = 0.50). Grade III-S meniscal signal was not associated with elevated T2 RVs over the MFC (p = 0.54), LFC (p = 0.43), MTP (p = 0.30), or LTP (p = 0.38). Conclusion: Grade III-C meniscal tears are associated with

  17. Integrity of articular cartilage on T2 mapping associated with meniscal signal change

    Energy Technology Data Exchange (ETDEWEB)

    Kai, Brian [Department of Radiology, University of British Columbia, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 (Canada); Mann, Sumeer A. [Department of Radiology, University of Alberta, Walter Mackenzie Health Sciences Center, Edmonton, AB, T6G 2B7 (Canada); King, Chris [Department of Radiology, University of British Columbia, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 (Canada); Forster, Bruce B., E-mail: bruce.forster@vch.ca [Department of Radiology, University of British Columbia, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 (Canada)

    2011-09-15

    Objective: The purpose of this study was to investigate the relationship between T2 relaxation values (T2 RVs) within the superficial zone of articular cartilage and different types of meniscal degeneration/tear. Materials and methods: A review of 310 consecutive knee MRIs which included an 8 echo T2 relaxation sequence, in patients referred for standard clinical indications, was performed independently and in blinded fashion by 2 observers. The posterior horns of the medial and lateral menisci were each evaluated and divided into 4 subgroups: Normal (control), Grade I/II meniscal signal, Grade III meniscal signal-simple tear (Grade III-S), and Grade III meniscal signal-complex tear (Grade III-C). After exclusion criteria were applied, the medial meniscal group consisted of 65 controls and 133 patients, while the lateral meniscal group consisted of 143 controls and 55 patients. T2 RVs were measured by an observer blinded to the clinical history and MRI grading. Measurements were obtained over the superficial zone of femoral and tibial articular cartilage adjacent to the center of the posterior horn of each meniscus to ensure consistency between measurements. Analysis of covariance adjusting for age and gender was used to compare T2 RVs between patients and controls. Results: T2 RVs were significantly increased in patients with Grade III-C meniscal tears compared to controls over the medial tibial plateau (MTP; p = 0.0001) and lateral tibial plateau (LTP; p = 0.0008). T2 RVs were not increased in patients with Grade III-C meniscal tears over the medial femoral condyle (MFC; p = 0.11) or lateral femoral condyle (LFC; p = 0.99). Grade I/II meniscal signal was not associated with elevated T2 RVs over the MFC (p = 0.15), LFC (p = 0.69), MTP (p = 0.42), or LTP (p = 0.50). Grade III-S meniscal signal was not associated with elevated T2 RVs over the MFC (p = 0.54), LFC (p = 0.43), MTP (p = 0.30), or LTP (p = 0.38). Conclusion: Grade III-C meniscal tears are associated with

  18. Vulnerability of the Superficial Zone of Immature Articular Cartilage to Compressive Injury

    Energy Technology Data Exchange (ETDEWEB)

    Rolauffs, R.; Muehleman, C; Li, J; Kurz, B; Kuettner, K; Frank, E; Grodzinsky, A

    2010-01-01

    The zonal composition and functioning of adult articular cartilage causes depth-dependent responses to compressive injury. In immature cartilage, shear and compressive moduli as well as collagen and sulfated glycosaminoglycan (sGAG) content also vary with depth. However, there is little understanding of the depth-dependent damage caused by injury. Since injury to immature knee joints most often causes articular cartilage lesions, this study was undertaken to characterize the zonal dependence of biomechanical, biochemical, and matrix-associated changes caused by compressive injury. Disks from the superficial and deeper zones of bovine calves were biomechanically characterized. Injury to the disks was achieved by applying a final strain of 50% compression at 100%/second, followed by biomechanical recharacterization. Tissue compaction upon injury as well as sGAG density, sGAG loss, and biosynthesis were measured. Collagen fiber orientation and matrix damage were assessed using histology, diffraction-enhanced x-ray imaging, and texture analysis. Injured superficial zone disks showed surface disruption, tissue compaction by 20.3 {+-} 4.3% (mean {+-} SEM), and immediate biomechanical impairment that was revealed by a mean {+-} SEM decrease in dynamic stiffness to 7.1 {+-} 3.3% of the value before injury and equilibrium moduli that were below the level of detection. Tissue areas that appeared intact on histology showed clear textural alterations. Injured deeper zone disks showed collagen crimping but remained undamaged and biomechanically intact. Superficial zone disks did not lose sGAG immediately after injury, but lost 17.8 {+-} 1.4% of sGAG after 48 hours; deeper zone disks lost only 2.8 {+-} 0.3% of sGAG content. Biomechanical impairment was associated primarily with structural damage. The soft superficial zone of immature cartilage is vulnerable to compressive injury, causing superficial matrix disruption, extensive compaction, and textural alteration, which results

  19. Manifestações articulares nas viroses exantemáticas Joint complaints in exanthematic diseases

    Directory of Open Access Journals (Sweden)

    Solange Artimos de Oliveira

    1999-04-01

    Full Text Available A freqüência de manifestações articulares foi avaliada em 251 pacientes com diagnóstico clínico e laboratorial (detecção de IgM por ensaio imunoenzimático de virose exantemática. As artropatias (artralgia e/ou artrite foram mais observadas nos casos de dengue (49% e de rubéola (38,2% do que naqueles com parvovirose humana (30% e sarampo (28,1%. Com exceção do sarampo, as artropatias predominaram nos adultos (315 anos de idade, sendo tal diferença estatisticamente significativa. A ocorrência maior de artropatias em adultos foi mais evidente nos pacientes com parvovirose (75%, rubéola (65% e dengue (57,7% do que naqueles com sarampo (31%. As queixas articulares também predominaram nos pacientes do sexo feminino para todas as viroses avaliadas. Os resultados encontrados demonstram o freqüente acometimento articular nas doenças estudadas, e indicam a necessidade de comprovação laboratorial para o diagnóstico diferencial entre elas.The frequency of arthropathy was evaluated in 251 patients with clinical and serological diagnosis (specific IgM detection by enzyme immunoassay of exanthematic disease. Arthropathy (arthralgia and/or arthritis was more frequent in dengue fever (49% and rubella (38.2% cases than in human parvovirus (30% and measles (28.1% cases. Except for measles cases, joint complaints prevailed in adults (315 years of age and this difference was significant. The higher frequency of arthropathy in adults was more evident in human parvovirus (75%, rubella (65% and dengue fever (57.7% cases than in measles cases (31%. Arthropathy was also more frequent in females for all rash diseases studied. The results of this study showed the high occurrence of joint complaints in the diseases described here and the importance of laboratory confirmation for their differential diagnosis.

  20. Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats.

    Science.gov (United States)

    Cui, Zhuang; Xu, Changpeng; Li, Xue; Song, Jinqi; Yu, Bin

    2015-05-01

    Osteoarthritis (OA) is a most commonly multifactorial degenerative joint disease along with the aging population, particularly in postmenopausal women. During the onset of OA, articular cartilage and subchondral bone act in concert as a functional unit. This present study is to investigate the effects of early or late treatment with recombinant lubricin on the onset of osteoarthritis (OA) in ovariectomized (OVX) rats. We found that both early and late recombinant lubricin treatments attenuated the onset of OA by positive feedback loop between articular cartilage and subchondral bone, although late treatment contributed to a lesser effect compared with early treatment. Specifically, treatment with recombinant lubricin protected articular cartilage from degeneration, demonstrated by lower proteoglycan loss, lower OARSI scores, less calcification cartilage zone and reduced immunostaining for collagen X (Col X) and matrix metalloproteinase (MMP-13) but increased the expression of lubricin, in comparison with vehicle-treated OVX rat group. Further, chondroprotective effects of lubricin normalized bone remodeling in subchondral bone underneath. It's suggested that treatment with recombinant lubricin inhibited the elevation of TRAP and Osterix positive cells in OVX rats and led to the normalization of subchondral bone microarchitectures with the suppression of subsidence of bone volume ratio (BV/TV) and trabecular thickness (Tb.Th) and the increase of trabecular separation (Tb.Sp) in vehicle-treated OVX rats. What's more, the normalization of subchondral bone in turn attenuated the articular cartilage erosion by inhibiting vascular invasion from subchondral bone to calcified cartilage zone, exemplified by inhibiting the elevation of CD31 positive cells in calcified cartilage and angiography in subchondral bone. Together, these results shed light that both early and late recombinant lubricin treatments attenuate the onset of OA by balancing the interplay between articular