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Sample records for arterial como factor

  1. Hipertensión arterial como factor predictivo en pacientes con cáncer renal tratados con antiangiogénicos

    OpenAIRE

    2011-01-01

    El conocimiento de las diversas vías de oncogénesis ha llevado al desarrollo en los últimos cinco años de nuevas terapias para el tratamiento del cáncer renal avanzado, las que poseen como blanco al factor derivado del endotelio vascular (VEGF) y sus receptores (antiangiogénicos) y al blanco mamífero de la rapamicina (mTOR). Los antiangiogénicos constituyen un grupo de moléculas activas con un espectro de toxicidad peculiar que comprende el desarrollo de hipertensión arterial, disfunción tiro...

  2. Hipertensión arterial como factor predictivo en pacientes con cáncer renal tratados con antiangiogénicos Hypertension as predictive factor in renal cell cancer treated with antiangiogenic therapy

    OpenAIRE

    Luciana Gennari; Javier Belinky; Claudio Graziano; Gustavo Jankilevich

    2011-01-01

    El conocimiento de las diversas vías de oncogénesis ha llevado al desarrollo en los últimos cinco años de nuevas terapias para el tratamiento del cáncer renal avanzado, las que poseen como blanco al factor derivado del endotelio vascular (VEGF) y sus receptores (antiangiogénicos) y al blanco mamífero de la rapamicina (mTOR). Los antiangiogénicos constituyen un grupo de moléculas activas con un espectro de toxicidad peculiar que comprende el desarrollo de hipertensión arterial, disfunción tiro...

  3. Intervenção Coronariana Percutânea prévia como fator de risco para Revascularização Miocárdica Previous percutaneous coronary intervention as risk factor for coronary artery bypass grafting

    Directory of Open Access Journals (Sweden)

    Luiz Augusto Ferreira Lisboa

    2012-07-01

    Full Text Available FUNDAMENTO: A Intervenção Coronariana Percutânea (ICP vem aumentando na doença arterial coronariana crônica. Consequentemente, cada vez mais pacientes submetidos a Cirurgia de Revascularização Miocárdica (CRM apresentam stent coronariano. OBJETIVO: Avaliar a influência do antecedente de stent coronariano na mortalidade hospitalar após CRM. MÉTODOS: Análise prospectiva com 1.099 pacientes consecutivos submetidos a CRM com circulação extracorpórea, entre maio/2007 e junho/2009. Pacientes sem ICP prévia (n = 938; 85,3% foram comparados com pacientes com ICP prévia (n = 161; 14,6%, utilizando modelos de regressão logística e análise de pareamento de amostras. RESULTADOS: Ambos os grupos apresentavam semelhança em relação aos fatores de risco, exceto pela maior presença de pacientes com angina instável no grupo com ICP prévia (16,1% vs. 9,9%; p = 0,019. A mortalidade hospitalar após CRM foi maior entre os pacientes com ICP prévia (9,3% vs. 5,1%, p = 0,034, e foi semelhante à esperada em relação ao EuroSCORE e ao 2000 Bernstein-Parsonnet score. Na análise com regressão logística multivariada a ICP prévia emergiu como fator de risco independente para mortalidade hospitalar pós-operatória (odds ratio 1,94; IC 95% 1,02-3,68; p = 0,044 tão forte quanto diabetes (odds ratio 1,86; IC 95% 1,07-3,24; p = 0,028. Após o pareamento dos grupos, a mortalidade hospitalar continuou sendo maior entre os pacientes com ICP prévia, com odds ratio 3,46 ; IC 95% 1,10-10,93; p = 0,034. CONCLUSÃO: A ICP prévia em pacientes com doença coronariana multiarterial é fator de risco independente para mortalidade hospitalar após CRM. Tal fato deve ser considerado quando a ICP for indicada como alternativa inicial em pacientes com doença arterial coronariana mais avançada. (Arq Bras Cardiol. 2012; [online].ahead print, PP.0-0BACKGROUND: Percutaneous coronary intervention (PCI has increased as the initial revascularization strategy in

  4. Uso crônico de decanoato de nandrolona como fator de risco para hipertensão arterial pulmonar em ratos Wistar Chronic use of nandrolone decanoate as risk factor for pulmonary arterial hypertension in Wistar rats

    OpenAIRE

    Jones Bernardes Graceli; Pablo Lúcio Gava; Helena Lima Gomes; Leonardo Moreira Moscon; Patrick Wander Endlich; Washington Luiz Silva Gonçalves; Margareth Ribeiro Moysés

    2010-01-01

    INTRODUÇÃO: O uso indiscriminado de esteróides anabolizantes sintéticos, análogos à testosterona, implica aumento do risco cardiovascular e hipertrofia cardíaca. Assim, o aumento da massa ventricular direita corrigido pelo peso corporal (i.é., hipertrofia ventricular direita - HVD), poderia elevar o risco para o desenvolvimento de hipertensão arterial pulmonar (HAP). OBJETIVOS: Examinar os efeitos do tratamento em longo prazo com decanoato de nadrolona na HVD e sua relação com a HAP em ratos....

  5. Uso crônico de decanoato de nandrolona como fator de risco para hipertensão arterial pulmonar em ratos Wistar Chronic use of nandrolone decanoate as risk factor for pulmonary arterial hypertension in Wistar rats

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    Jones Bernardes Graceli

    2010-02-01

    Full Text Available INTRODUÇÃO: O uso indiscriminado de esteróides anabolizantes sintéticos, análogos à testosterona, implica aumento do risco cardiovascular e hipertrofia cardíaca. Assim, o aumento da massa ventricular direita corrigido pelo peso corporal (i.é., hipertrofia ventricular direita - HVD, poderia elevar o risco para o desenvolvimento de hipertensão arterial pulmonar (HAP. OBJETIVOS: Examinar os efeitos do tratamento em longo prazo com decanoato de nadrolona na HVD e sua relação com a HAP em ratos. MÉTODOS: 16 ratos Wistar com três meses de idade foram aleatoriamente divididos em dois grupos: 1 controle-sham (CONT, n = 8; 2 tratados com decanoato de nandrolona (DECA, n = 8. O tratamento consistiu na aplicação intramuscular de Deca-durabolin® 6.0mg.kg-1 de peso corporal durante quatro semanas. Após tratamento, os animais foram anestesiados com hidrato de cloral (4.0mL.kg-1, i.p., submetidos à cateterização da artéria femoral para registro da pressão arterial media (PAM e frequência cardíaca (FC. O coração, os rins e o fígado foram retirados, pesados e avaliados os índices de hipertrofia, os quais foram calculados pela razão da massa do órgão pelo peso corporal (mg.g-1. RESULTADOS: Os animais tratados com DECA apresentaram aumento (p INTRODUCTION: The unsystematic use of anabolic steroids, synthetic analogs of testosterone, implies enhanced cardiovascular risk and cardiac hypertrophy. Thus, increased right ventricular mass corrected by the body weight (e.g.right ventricular hypertrophy -RVH could raise the risk for development of pulmonary arterial hypertension (PAH. OBJECTIVES: to examine the effects of long-term chronic treatment with nandrolone decanoate on the RVH and its relationship with PAH in rats. METHODS: 16 three-month Wistar male rats were treated with nandrolone decanoate (6.0 mg/kg-1 body weight; DECA, n=8 or control vehicle (CONT, n=8. The drug and vehicle were administered by a single injection in the femoral

  6. External aggression to the limb as a predictive factor in the evolution of patients undergoing arterial revascularization Agressão externa aos membros inferiores como fator preditivo na evolução dos pacientes submetidos a revascularização arterial

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    Nelson Wolosker

    2005-12-01

    Full Text Available PURPOSE: A variety of predictive factors for the evolution of arterial grafts in patients with critical ischemia have been well defined in clinical studies, including diabetes mellitus, dialytic renal insufficiency, smoking, and distal arterial runoff. The goal of this study was to determine whether patients with critical ischemia undergoing arterial reconstruction in which ischemic lesions appeared spontaneously, compared to those in which the ischemic lesion appeared following an external aggression to the limb present different patterns of evolution. METHODS: From February 2002 to January 2004, 100 patients undergoing infra-inguinal arterial reconstruction were followed. They were divided into 2 groups: 1 the spontaneous group (n = 52, comprising individuals presenting with ischemic lesions of spontaneous origin and 2 the external aggression to the limb group (n = 48, comprising individuals for which an external causal mechanism for the appearance of the ischemic lesion was identified. The variables analyzed were limb salvage and graft functioning rates. RESULTS: Patients with spontaneous lesions had rates of limb salvage and graft functioning significantly lower than those for patients with lesions that were secondary to external aggression (42.3% versus 87.5%, respectively for both outcomes; P OBJETIVO: Diversos fatores preditivos de evolução de enxertos arteriais em pacientes com isquemia grave foram definidos em estudos clínicos como diabetes mellitus, insuficiência renal, fumo e vasão distal. O objetivo deste estudo foi verificar se pacientes com isquemia grave submetidos a revascularização nos quais as lesões apareceram espontaneamente apresentam evolução diferente daquela em que as lesões apareceram após uma agressão externa ao membro. MÉTODOS: De fevereiro de 2002 a janeiro de 2004, 100 pacientes submetidos a revascularizações infra-inguinais foram seguidos. Eles foram divididos em 2 grupos: 1 Grupo com lesão espont

  7. Cervical Artery Dissection: Emerging Risk Factors

    OpenAIRE

    Micheli, S.; Paciaroni, M; Corea, F; Agnelli, G.; M. Zampolini; Caso, V

    2010-01-01

    Cervical artery dissection (CAD) represents an increasingly recognized cause of stroke and the most common cause of ischemic stroke in young adults. Many factors have been identified in association with CAD such as primary disease of arterial wall (fibrodysplasia) and other non-specific diseases related to CAD like Ehlers Danlos-syndrome IV, Marfan’s syndrome, vessel tortuosity. Moreover, an underlying arteriopathy which could be in part genetically determined, has been suspected. The rule of...

  8. Cervical artery dissection: emerging risk factors.

    Science.gov (United States)

    Micheli, S; Paciaroni, M; Corea, F; Agnelli, G; Zampolini, M; Caso, V

    2010-01-01

    Cervical artery dissection (CAD) represents an increasingly recognized cause of stroke and the most common cause of ischemic stroke in young adults. Many factors have been identified in association with CAD such as primary disease of arterial wall (fibrodysplasia) and other non-specific diseases related to CAD like Ehlers Danlos-syndrome IV, Marfan's syndrome, vessel tortuosity. Moreover, an underlying arteriopathy which could be in part genetically determined, has been suspected. The rule of emerging risk factors for CAD such as recent respiratory tract infection, migraine and hyperhomocysteinemia are still a matter of research. Other known risks factors for CAD are major head/neck trauma like chiropractic maneuver, coughing or hyperextension injury associated to car. We examined emerging risks factors for CAD detected in the last years, as CAD pathogenesis is still not completely understood and needs further investigations. PMID:21270941

  9. Ecosistemas como factores de bienestar y desarrollo.

    OpenAIRE

    MÁRQUEZ, GERMÁN

    2011-01-01

    Los ecosistemas proveen más bienes y servicios a la sociedad de lo que generalmente se reconoce. Un ensayo de clasificación de esos bienes y servicios debe incluir: 1) Satisfacci6n de necesidades básicas, como agua, energía y abastecimiento de alimentos. 2) respaldar los procesos productivos, industriales o agropecuarios, con materias primas, agua y abastecimiento de energía. 3) Asimilación de desechos (sólidos, líquidos o gaseosos) de las actividades humanas, en ríos, inmundicias y atmósfera...

  10. Hipertensão arterial pulmonar hereditária apresentando-se como venopatia oclusiva

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    Sonia Meiken Franchi

    2011-07-01

    Full Text Available Um homem de 33 anos com hipertensão arterial pulmonar hereditária teve um diagnóstico confirmado de venopatia oclusiva e microvasculopatia. O paciente permaneceu estável por 3 anos e meio recebendo sildenafila via oral, 75 mg 3x/dia (teste de caminhada de seis minutos de 375 m vs 105 m basal, mas necessitou da adição de bosentana (125 mg 2x/dia posteriormente. A despeito do desfecho fatal após 5 anos, as observações sugerem um utilidade potencial dos vasodilatadores como uma ponte para o transplante de pulmão em casos selecionados com envolvimento venocapilar significante. A ocorrência de lesões veno-oclusivas e capilares na forma familiar da hipertensão arterial pulmonar enfatiza as dificuldades com a atual classificação da doença.

  11. Indicadores antropométricos como preditores de pressão arterial elevada em adolescentes

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    Carmem Cristina Beck

    2011-02-01

    Full Text Available FUNDAMENTO: A hipertensão arterial está relacionada ao incremento da gordura corporal, a qual pode ser avaliada por meio de indicadores antropométricos. OBJETIVO: Determinar o poder preditivo de indicadores antropométricos e estabelecer seus pontos de corte como discriminadores de pressão arterial elevada. MÉTODOS: Estudo transversal realizado com uma amostra de 660 adolescentes de 14 a 19 anos sendo 51,9% moças. Foram considerados os seguintes indicadores antropométricos: índice de massa corporal (IMC, circunferência da cintura, razão cintura/estatura e índice de conicidade. A pressão arterial elevada foi caracterizada por valores acima do percentil 90 para pressão arterial sistólica e/ou pressão arterial diastólica. Para identificação dos preditores de pressão arterial elevada, foi adotada a análise das curvas Receiver Operating Characteristic (ROC, com intervalo de confiança de 95%. Posteriormente, identificaram-se os pontos de corte com suas respectivas sensibilidades e especificidades. RESULTADOS: As áreas sob as curvas ROC com os intervalos de confiança foram: rapazes - circunferência de cintura = 0,80 (0,72-0,89; IMC = 0,79 (0,68-0,89; razão cintura/estatura = 0,77 (0,66-0,88; índice de conicidade = 0,69 (0,56-0,81 e para as moças - circunferência de cintura = 0,96 (0,92-1,00; IMC = 0,95 (0,87-1,00; razão cintura/estatura = 0,93 (0,85-1,00; índice de conicidade = 0,74 (0,50-0,98. Os diversos pontos de corte dos indicadores antropométricos com melhores poderes preditivos e suas respectivas sensibilidades e especificidades foram identificados. CONCLUSÃO: Apesar de a razão cintura/estatura e de o IMC terem apresentado boas áreas sob a curva ROC, sugere-se a utilização da circunferência de cintura para a predição da pressão arterial elevada.

  12. La preeclampsia y la hipertensión gestacional como factores de riesgo para el desarrollo del estado de prehipertensión y de hipertensión arterial a las doce semanas posparto. Un estudio descriptivo prospectivo

    OpenAIRE

    Bernardo Agudelo Jaramillo; Joaquín Guillermo Gómez Dávila; Samuel Eduardo Gélvez Téllez; Elkin Darío Cuartas Arias

    2008-01-01

    OBJETIVO: explorar si la preeclampsia y la hipertensión gestacional son factores de riesgo para los estados prehipertensivo e hipertensivo a las doce semanas posparto. DISEÑO: estudio descriptivo prospectivo de pacientes del área metropolitana del valle de Aburrá, hospitalizadas por preeclampsia o hipertensión gestacional, a quienes se les atendió el parto en el Hospital Universitario San Vicente de Paúl de Medellín, Colombia, y se les hizo seguimiento hasta las doce semanas posparto. MÉTODO:...

  13. Factors for vertebral artery injury accompanied by cervical trauma

    International Nuclear Information System (INIS)

    Injury of the vertebral artery with cerebellar and brain stem infarction is a complication of cervical vertebral trauma. However, the pathogenesis and etiological factors remain to be clarified. In this study, we investigated patients with cervical vertebral and cord injury. This study included 51 patients with cervical vertebral and cord injury who were treated in our department. In these patients, plain X-ray, CT, MRI, and MRA findings were examined. The incidence of vertebral arterial injury was 33.3% (17 of 51 patients with cervical vertebral trauma). In 11 of the 17 patients, dislocation fracture was noted, comprising a markedly high percentage (64.7%). Particularly, vertebral arterial injury was commonly observed in patients with a large dislocation distance and severe paralysis. Cerebellar and brain stem infarction related to vertebral arterial injury was observed in 5 of the 17 patients (29.4%). No infarction developed in patients 50 years old or younger. Infarction was detected in relatively elderly patients. Vertebral arterial injury and cerebellar/brain stem infarction related to cervical vertebral trauma were frequently observed in patients with high energy injury. However, these disorders commonly occurred in elderly patients. Therefore, age-related factors such as arteriosclerosis may also be closely involved. In the acute stage, the state of the vertebral artery should be evaluated by MRA and MRI. Among patients with vertebral arterial injury, caution is needed during follow-up those with risk factors such as high energy injury and advanced age. (author)

  14. Factors for vertebral artery injury accompanied by cervical trauma

    Energy Technology Data Exchange (ETDEWEB)

    Murata, Masaaki; Shingu, Hikosuke; Kimura, Isao; Nasu, Yoshiro; Shiotani, Akihide [San-in Rosai Hospital, Yonago, Tottori (Japan). Spine and Low Back Pain Center

    2001-09-01

    Injury of the vertebral artery with cerebellar and brain stem infarction is a complication of cervical vertebral trauma. However, the pathogenesis and etiological factors remain to be clarified. In this study, we investigated patients with cervical vertebral and cord injury. This study included 51 patients with cervical vertebral and cord injury who were treated in our department. In these patients, plain X-ray, CT, MRI, and MRA findings were examined. The incidence of vertebral arterial injury was 33.3% (17 of 51 patients with cervical vertebral trauma). In 11 of the 17 patients, dislocation fracture was noted, comprising a markedly high percentage (64.7%). Particularly, vertebral arterial injury was commonly observed in patients with a large dislocation distance and severe paralysis. Cerebellar and brain stem infarction related to vertebral arterial injury was observed in 5 of the 17 patients (29.4%). No infarction developed in patients 50 years old or younger. Infarction was detected in relatively elderly patients. Vertebral arterial injury and cerebellar/brain stem infarction related to cervical vertebral trauma were frequently observed in patients with high energy injury. However, these disorders commonly occurred in elderly patients. Therefore, age-related factors such as arteriosclerosis may also be closely involved. In the acute stage, the state of the vertebral artery should be evaluated by MRA and MRI. Among patients with vertebral arterial injury, caution is needed during follow-up those with risk factors such as high energy injury and advanced age. (author)

  15. Renal artery stenosis in patients with established coronary artery disease: Prevalence and predicting factors

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    Mohammad Reza Khatami

    2014-01-01

    Full Text Available The association between renal artery stenosis (RAS and other atherosclerotic diseases (particularly coronary artery diseases is well known. In general, the risk factors for atherosclerosis have been clarified, but whether these risk factors operate equally in all forms of atherosclerotic diseases is not known. The aim of this study was to describe the prevalence of RAS in patients with established coronary artery diseases and then to define the most important risk factors that may help to predict the RAS in this population. In this cross-sectional study, 146 patients with established coronary artery stenosis by angiography simultaneously underwent renal angiography; RAS >50% was considered significant. We found that 25.3% of patients with coronary artery diseases had RAS. The prevalence of significant stenosis was 17.1%. Females were more vulnerable to this disorder than males (47.1% vs. 13.7%, P = 0.001. There was no relationship between the severity and number of stenosed coronary arteries and those of stenosed renal arteries (P = 0.716. Multi-variate logistic regression analysis revealed that among the risk factors for atherosclerosis, female sex (P = 0.001, duration of hypertension (P = 0.032, age (P = 0.046 and serum creatinine (P = 0.018 were strong predictors of the presence of RAS. We concluded that RAS is a common finding in patients with coronary artery disease. We suggest that all older females with deteriorating renal function and long-standing hypertension should be carefully evaluated for early detection of the RAS.

  16. Tabaquismo como factor de riesgo del infarto agudo al miocardio

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    Manrique Leal-Mateos

    2006-06-01

    Full Text Available Justificación: El tabaquismo es la principal causa de enfermedad, discapacidad y muerte prematura prevenible mundialmente; actualmente, es aceptado como un factor de riesgo para el desarrollo de enfermedades cardiovasculares. Sin embargo, aunque el tabaco es conocido como una causa directa de IAM, en el país es limitado el conocimiento de su fracción atribuible. Objetivo: Este estudio tiene como propósito evaluar el impacto que provoca el tabaquismo sobre los pacientes con IAM, por medio de su fracción atribuible. Así, pretende estimar la proporción de personas que podrían prevenir su desarrollo, si se evitara la exposición a este factor de riesgo. Métodos: Se realizó un estudio de casos y controles en los servicios de medicina interna y cirugía del Hospital San Juan de Dios, en el periodo comprendido entre el 1 de abril y el 23 de septiembre de 2005. Se definió como fumador aquel paciente que hubiera fumado al menos un cigarro por día, durante un año. De acuerdo con el hábito de fumar, se clasificaron en: No fumadores (quienes nunca habían fumado, fumadores (quienes fumaran actualmente y exfumadores. La magnitud de las asociaciones entre la exposición y el riesgo de la enfermedad se evaluó mediante la razón de probabilidades (Odds Ratio en inglés para datos apareados 2:1, definiendo como no expuestos aquellos pacientes clasificados como no fumadores. Los exfumadores con más de 15 años de haber abandonado el hábito fueron clasificados como no fumadores (dados los beneficios que representa esta situación a largo plazo y aquellos con menos de 15 años de haberlo abandonado, fumadores. Con el fin de medir el impacto del tabaquismo sobre los pacientes que padecen de infarto agudo al miocardio se utilizó el indicador de fracción atribuible. Para todo lo anterior se utilizó Epitable, del programa EpiInfo 6. Resultados: La Razón de Probabilidades para datos apareados 2:1 mostró una asociación positiva entre el fumado y

  17. Homocysteine as risk factor for coronary artery disease in pakistan

    International Nuclear Information System (INIS)

    Pakistani people belong to an ethnic group which has the highest rate of coronary artery disease. There are a number of risk factors for developing the coronary artery disease (CAD). Homocysteine, a sulphur containing amino acid, has been reported to be an independent risk factor for CAD. The present study was done to find out the role of hyperhomocysteinemia in the development of coronary artery disease in Pakistan. Materials and Methods: A cross sectional study was carried out. There were 40 angiographically diagnosed male patients of coronary artery disease between 30 - 40 years of age taken as cases and 40 age, sex and socioeconomically matched healthy subjects with normal carotid doppler study taken as controls. Fasting venous blood from cases and controls was taken in E.D.T.A vacationers. Plasma was analyzed for homo-cysteine level by enzyme immunoassay method. Results: Mean plasma concentration of homocysteine in coronary artery disease patients i.e. cases was 13.5 +- 6.8 mu mol/L and was higher than the mean for controls (10.76 +- 2.27 mu mol/L) to a significant extent. Conclusion: Hyperhomocysteinemia through inter-play with the classical cardiovascular risk factors may be aggravating the risk of coronary artery disease in Pakistani people. (author)

  18. Tabaquismo como factor de riesgo del infarto agudo al miocardio

    Directory of Open Access Journals (Sweden)

    Manrique Leal-Mateos

    2006-06-01

    Full Text Available Justificación: El tabaquismo es la principal causa de enfermedad, discapacidad y muerte prematura prevenible mundialmente; actualmente, es aceptado como un factor de riesgo para el desarrollo de enfermedades cardiovasculares. Sin embargo, aunque el tabaco es conocido como una causa directa de IAM, en el país es limitado el conocimiento de su fracción atribuible. Objetivo: Este estudio tiene como propósito evaluar el impacto que provoca el tabaquismo sobre los pacientes con IAM, por medio de su fracción atribuible. Así, pretende estimar la proporción de personas que podrían prevenir su desarrollo, si se evitara la exposición a este factor de riesgo. Métodos: Se realizó un estudio de casos y controles en los servicios de medicina interna y cirugía del Hospital San Juan de Dios, en el periodo comprendido entre el 1 de abril y el 23 de septiembre de 2005. Se definió como fumador aquel paciente que hubiera fumado al menos un cigarro por día, durante un año. De acuerdo con el hábito de fumar, se clasificaron en: No fumadores (quienes nunca habían fumado, fumadores (quienes fumaran actualmente y exfumadores. La magnitud de las asociaciones entre la exposición y el riesgo de la enfermedad se evaluó mediante la razón de probabilidades (Odds Ratio en inglés para datos apareados 2:1, definiendo como no expuestos aquellos pacientes clasificados como no fumadores. Los exfumadores con más de 15 años de haber abandonado el hábito fueron clasificados como no fumadores (dados los beneficios que representa esta situación a largo plazo y aquellos con menos de 15 años de haberlo abandonado, fumadores. Con el fin de medir el impacto del tabaquismo sobre los pacientes que padecen de infarto agudo al miocardio se utilizó el indicador de fracción atribuible. Para todo lo anterior se utilizó Epitable, del programa EpiInfo 6. Resultados: La Razón de Probabilidades para datos apareados 2:1 mostró una asociación positiva entre el fumado y

  19. El lactato como posible factor del mecanismo de fatiga muscular.

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    José Carlos Giraldo T.

    2009-10-01

    Full Text Available Se revisa el papel del lactato en la función muscular. Se destacan los siguientes conceptos: el lactato es un intermediario metabólico que aumenta durante el ejercicio de alta intensidad, como consecuencia de la elevada actividad glicolítica. En esas condiciones la formación de ATP se asocia con generación de iones lactato e H+ y se reduce el pH de la célula activa. Si hay fatiga, el aumento en los niveles de lactato se correlaciona con la magnitud en la caída de la fuerza y los niveles de lactato alcanzados a un determinado nivel de actividad dependen del tipo de la fibra muscular. La salida de lactato de la fibra ocurre principalmente por 3 mecanismos de los cuales el más importante es el cotransporte acoplado de lactato-H+, cuya actividad depende del tipo de fibra y del patrón de activación así como del pH y de la concentración del amortiguador (buffer externos. De los varios factores responsables de la fatiga muscular, la disminución de pH se ha señalado como uno de los más importantes. No obstante, a pesar de la relación entre fatiga muscular y disminución de pHi, ésta no parece ser suficiente para explicar el grado de reducción de la fuerza durante la fatiga. Recientemente se han realizado experimentos que muestran un efecto inhibidor del lactato sobre el canal de liberación de calcio del retículo sarcoplásmico, lo que sugiere fuertemente que el lactato per se, y no necesariamente el cambio de pHi asociado, puede jugar un papel importante en el mecanismo de la fatiga. Por otra parte, el lactato podría tener efecto benéfico en la recuperación de la fuerza tetánica y de la capacidad de mantener la fase de meseta durante el tétanos, que se reducen por efecto de la fatiga. Asimismo, el aumento de lactato podría jugar un papel protector de la fibra durante la fatiga, mediante la activación de los canales de K+ sensibles a ATP. El músculo produce y consume lactato y al aumentar sus niveles en la sangre, este ion lo

  20. Modifiable risk factors for increased arterial stiffness in outpatient nephrology.

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    Usama Elewa

    Full Text Available Arterial stiffness, as measured by pulse wave velocity (PWV, is an independent predictor of cardiovascular events and mortality. Arterial stiffness increases with age. However, modifiable risk factors such as smoking, BP and salt intake also impact on PWV. The finding of modifiable risk factors may lead to the identification of treatable factors, and, thus, is of interest to practicing nephrologist. We have now studied the prevalence and correlates of arterial stiffness, assessed by PWV, in 191 patients from nephrology outpatient clinics in order to identify modifiable risk factors for arterial stiffness that may in the future guide therapeutic decision-making. PWV was above normal levels for age in 85/191 (44.5% patients. Multivariate analysis showed that advanced age, systolic BP, diabetes mellitus, serum uric acid and calcium polystyrene sulfonate therapy or calcium-containing medication were independent predictors of PWV. A new parameter, Delta above upper limit of normal PWV (Delta PWV was defined to decrease the weight of age on PWV values. Delta PWV was calculated as (measured PWV - (upper limit of the age-adjusted PWV values for the general population. Mean±SD Delta PWV was 0.76±1.60 m/sec. In multivariate analysis, systolic blood pressure, active smoking and calcium polystyrene sulfonate therapy remained independent predictors of higher delta PWV, while age, urinary potassium and beta blocker therapy were independent predictors of lower delta PWV. In conclusion, arterial stiffness was frequent in nephrology outpatients. Systolic blood pressure, smoking, serum uric acid, calcium-containing medications, potassium metabolism and non-use of beta blockers are modifiable factors associated with increased arterial stiffness in Nephrology outpatients.

  1. Factores cognitivos relacionados con la ira y la hostilidad en hipertensión arterial esencial

    OpenAIRE

    Magán Uceda, Inés

    2010-01-01

    La presente tesis doctoral tiene como objetivo principal el estudio del perfil psicológico de la hipertensión arterial esencial, especialmente en cuanto a la ira-hostilidad, siendo su principal novedad el estudio del papel de los factores cognitivos que propone Beck en su modelo ABC de la emoción, es decir, los pensamientos automáticos negativos y las creencias y actitudes disfuncionales relacionadas con la ira-hostilidad. La tesis doctoral se ha estructurado en tres partes: una primera parte...

  2. Factores de riesgo en empleados del área de la salud de manizales asociados con el desarrollo de hipertensión arterial sistémica

    OpenAIRE

    Cardona Gómez, Johanna; Castaño Castrillón, José Jaime; Giraldo Cardona, José Fernando; Giraldo Ciuffetelli, Natalia Eugenia; Hernández Vinasco, Valentina; Jiménez Páez, Diana Susana; Muñoz Villegas, Margarita María; Sepúlveda Gallo, Gloria Ángela; Sepúlveda Gómez, Isabel Juliana

    2010-01-01

    Antecedentes.La hipertensión arterial (HTA) se define como una presión arterial sistólica (PAS) mayor o igual a 140 mmHg o una presión arterial diastólica (PAD) mayor o igual a 90 mmHg medida en el paciente, siendo este uno de los principales motivos de consulta al médico. Objetivo. Obtener una mejor comprensión de los factores de riesgo comprometidos con la presentación de hipertensión arterial, en los empleados de los centros urbanos de Atención en Seguridad Social, Bienestar y Salud, ...

  3. Lifestyle Factors and Coronary Artery Calcification

    OpenAIRE

    Lee, Chong-Do; Jae, Sae Young

    2014-01-01

    The effective prevention of cardiovascular disease (CVD) remains a global health challenge. Adopting a combined primary (prevention of the first episode of coronary heart disease or stroke) and primordial (prevention of the causal risk factors of CVD) prevention strategy is the best approach to prevent CVD. Most importantly, the primordial prevention strategy should in the first place be to promote cardiovascular health across individual and population levels by improving the underlying causa...

  4. Arterial hypertension as risk factor for spontaneous cervical artery dissection. A case–control study

    OpenAIRE

    Pezzini, A; Caso, V; Zanferrari, C; Del Zotto, E; Paciaroni, M; Bertolino, C; Grassi, M.(INFN Sezione di Roma, Roma, Italy); Agnelli, G.; Padovani, A

    2006-01-01

    Because of the presumed non‐atherosclerotic pathogenesis, the potential link between spontaneous cervical artery dissection (sCAD) and common risk factors for atherosclerosis has never been investigated systematically. Therefore, this prospective, multicentre, case–control study compared the frequency of tobacco use, hypertension, diabetes mellitus, and hypercholesterolaemia among a group of consecutive patients with sCAD (n  =  153), a group of patients with ischaemic stroke, not related to ...

  5. Epidemiology, classification, and modifiable risk factors of peripheral arterial disease

    Directory of Open Access Journals (Sweden)

    Nicolas W Shammas

    2007-05-01

    Full Text Available Nicolas W ShammasMidwest Cardiovascular Research Foundation, Cardiovascular Medicine, PC, Davenport, IA, USAAbstract: Peripheral arterial disease (PAD is part of a global vascular problem of diffuse atherosclerosis. PAD patients die mostly of cardiac and cerebrovascular-related events and much less frequently due to obstructive disease of the lower extremities. Aggressive risk factors modification is needed to reduce cardiac mortality in PAD patients. These include smoking cessation, reduction of blood pressure to current guidelines, aggressive low density lipoprotein lowering, losing weight, controlling diabetes and the use of oral antiplatelet drugs such as aspirin or clopidogrel. In addition to quitting smoking and exercise, cilostazol and statins have been shown to reduce claudication in patients with PAD. Patients with critical rest limb ischemia or severe progressive claudication need to be treated with revascularization to minimize the chance of limb loss, reduce symptoms, and improve quality of life.Keywords: peripheral arterial disease, epidemiology, risk factors, classification

  6. Educación universitaria como factor de movilidad social

    Directory of Open Access Journals (Sweden)

    María Guadalupe Vélez Vázquez

    2014-05-01

    Full Text Available El decidir entrar o no a estudiar una carrera universitaria aún es visto como una posibilidad de mantenerse o mejorar las condiciones de vida de una buena parte de la población. A mediados de los noventas las Instituciones de Educación Superior (IES de la Región del Évora, mostraron un fenómeno socioeducativo, mayor participación de las mujeres en estos niveles, provenientes de diferentes municipios y localidades rurales. Esta investigación describe la dinámica y elementos o factores de movilidad social de egresadas universitarias, las categorías de estudio fueron el nivel educativo de la familia de origen (abuelos y padres, incorporación de las egresadas a estudios preuniversitarios y universitarios, situación laboral, su posición socioeconómica y los elementos de la movilidad o inmovilidad social. La investigación se abordó desde una perspectiva fenomenológica, con enfoque cualitativo, en la recopilación de datos se utilizaron las técnicas de investigación: entrevista estructurada y documental, se aplicaron 68 entrevistas y fichas de caracterización socioeconómica. De los aspectos sociales, casi en su totalidad, las familias de origen son de escasos recursos, sin estudios y residen o habitaron en contexto con características de vida rural; la mayoría de las egresadas son la primera generación que logra un nivel superior educativo, se encuentran desarrollando una actividad laboral, sin embargo, reproducen el nivel socioeconómico de su familia de origen, principalmente la de los padres y el elemento de movilidad social, no es sólo la educación sino es familia-educación. Palabras clave: Movilidad social, posición socioeconómica, egresadas universitarias.

  7. Value of multiple risk factors in predicting coronary artery disease

    International Nuclear Information System (INIS)

    Objective: This study sought to assess the relationship between correlative comprehension risk factors and coronary arterial disease and to build up a simple mathematical model to evaluate the extension of coronary artery lesion in patients with stable angina. Methods: A total of 1024 patients with chest pain who underwent coronary angiography were divided into CAD group(n=625)and control group(n=399) based on at least one significant coronary artery narrowing more than 50% in diameter. Independent risk factors for CAD were evaluated and multivariate logistic regression model and receiver-operating characteristic(ROC) curves were used to estimate the independent influence factor for CAD and built up a simple formula for clinical use. Results: Multivariate regression analysis revealed that UACR > 7.25 μg/mg(OR=3.6; 95% CI 2.6-4.9; P20 mmol/L(OR=3.2; 95% CI 2.3-4.4; P2(OR=2.3; 95% CI 1.4-3.8; P 2.6 mmol/L (OR 2.141; 95% CI 1.586-2.890; P 7.25 μg/mg + 1.158 x hsCRP > 20 mmol/L + 0.891 GFR 2 + 0.831 x LVEF 2.6 mmol/L + 0.676 x smoking history + 0.594 x male + 0.459 x diabetes + 0.425 x hypertension). Area under the curve was 0.811 (P < 0.01), and the optimal probability value for predicting severe stage of CAD was 0.977 (sensitivity 49.0%, specificity 92.7% ). Conclusions: Risk factors including renal insufficiency were the main predictors for CAD. The logistic regression model is the non-invasive method of choice for predicting the extension of coronary artery lesion in patients with stable agiana. (authors)

  8. Midterm Outcome of Femoral Artery Stenting and Factors Affecting Patency

    OpenAIRE

    Yu, Jae Seoung; Park, Keun-Myoung; Jeon, Yong Sun; Cho, Soon Gu; Hong, Kee Chun; Shin, Woo Young; Choe, Yun-Mee; Shin, Seok-Hwan; Kim, Kyung Rae

    2015-01-01

    Purpose: The purpose of this study was to evaluate the early and midterm results of superficial femoral artery (SFA) stenting with self-expanding nitinol stents and to identify the factors affecting patency. Materials and Methods: SFA stenting was performed in 165 limbs of 117 patients from January 2009 to December 2013. Patients were followed-up for the first occurrence of occlusion or stenosis based on computed tomography and duplex scan results and a decrease in ankle brachial index of >15...

  9. FACTORES DE RIESGO EN EMPLEADOS DEL ÁREA DE LA SALUD DE MANIZALES ASOCIADOS CON EL DESARROLLO DE HIPERTENSIÓN ARTERIAL SISTÉMICA Hypertension risk factor in health workes in Manizales - Colombia

    OpenAIRE

    Johanna Cardona Gómez; José Jaime Castaño Castrillón; José Fernando Giraldo Cardona; Natalia Eugenia Giraldo Ciuffetelli; Valentina Hernández Vinasco; Diana Susana Jiménez Páez; Margarita María Muñoz Villegas; Gloria Ángela Sepúlveda Gallo; Isabel Juliana Sepúlveda Gómez

    2008-01-01

    Antecedentes. La hipertensión arterial (HTA) se define como una presión arterial sistólica (PAS) mayor o igual a 140 mmHg o una presión arterial diastólica (PAD) mayor o igual a 90 mmHg medida en el paciente, siendo este uno de los principales motivos de consulta al médico. Objetivo. Obtener una mejor comprensión de los factores de riesgo comprometidos con la presentación de hipertensión arterial, en los empleados de los centros urbanos de Atención en Seguridad Social, Bienestar y Salud, empr...

  10. The Association of Coronary Artery Calcification and Carotid Artery Intima-Media Thickness With Distinct, Traditional Coronary Artery Disease Risk Factors in Asymptomatic Adults

    OpenAIRE

    Rampersaud, Evadnie; Bielak, Lawrence F.; Parsa, Afshin; Shen, Haiqing; Post, Wendy; Ryan, Kathleen A.; Donnelly, Patrick; Rumberger, John A.; Sheedy, Patrick F; Peyser, Patricia A.; Shuldiner, Alan R.; Mitchell, Braxton D.

    2008-01-01

    Coronary artery calcification (CAC) and common carotid artery intima-media thickness (CIMT) are measures of subclinical vascular disease. This 2000–2006 study aimed to characterize the associations among coronary artery disease risk factors, CAC quantity, and CIMT and to estimate shared genetic and environmental contributions to both CAC and CIMT among 478 asymptomatic Amish adults in Lancaster County, Pennsylvania. Heritability for CAC quantity and CIMT, adjusted for age and sex, was 0.42 (P...

  11. Relation of anthropometric variables to coronary artery disease risk factors

    Directory of Open Access Journals (Sweden)

    Virendra C Patil

    2011-01-01

    Full Text Available Background and Objectives: Anthropometric variables and their relation to conventional coronary artery disease (CAD risk factors in railway employees have been inadequately studied in India. This cross-sectional survey was carried out in the Solapur division of the Central railway in the year 2004, to assess the anthropometric variables in railway employees and their relation to conventional CAD risk factors. Materials and Methods: A total of 995 railway employees, with 872 males and 123 females participated in this cross-sectional study. All subjects underwent anthropometric measurements, fasting lipid profile, and blood sugar level. Various anthropometric indices were calculated for body mass index (BMI, waist circumference (WC, waist-to-hip ratio (WHR, waist-to-height ratio (WHtR, and abdominal volume index (AVI. Statistical analysis was done by EPI Info 6 statistical software. Results: Compared to all other obesity indices, WHtR was most prevalent in both genders. High WHtR was present in 699 (80.16% males and 103 (83.73% females. Age ≥45 years, high systolic BP, high diastolic BP, low HDL, high triglyceride, and diabetes mellitus were positively correlated with high BMI, high WC, high WHR, high WHtR, and high AVI. High BMI, high WC, high WHR, high WHtR, and high AVI were negatively associated with physical inactivity. Conclusions: Over all, anthropometric variables in both genders were significantly deranged in subjects with coronary risk factors. Compared to all other anthropometric variables, WHtR was statistically significantly associated with a majority of coronary artery risk factors. Hence we recommend inclusion of WHtR as a parameter of obesity to predict coronary artery disease risk factor along with WC, WHR, and BMI in epidemiologic studies.

  12. La innovación como factor de calidad en las organizaciones educativas

    OpenAIRE

    Ma. José Fernández Díaz

    2005-01-01

    En este artículo se analiza la innovación como factor fundamental de la calidad de las organizaciones educativas, tal y como se considera en los distintos modelos y sistemas de la calidad, como el EFQM. La relación y diferencias entre innovación y cambio así como las características fundamentales de los procesos de innovación permiten una mejor comprensión de los mismos. Las dificultades de implantación de acciones innovadoras en los centros y los factores o condiciones que los...

  13. LEGITIMIDAD COMO FACTOR CLAVE DEL ÉXITO ORGANIZATIVO

    Directory of Open Access Journals (Sweden)

    Díez Martín, F.

    2010-01-01

    Full Text Available Este trabajo pretende recopilar y ordenar la literatura existente sobre la legitimidad organizativa, señalando su importancia para el desarrollo de las organizaciones. El argumento central del trabajo considera que existen determinadas acciones estratégicas organizativas cuyo desarrollo permite la obtención, el mantenimiento y la recuperación de legitimidad, la cual favorece el acceso a recursos estratégicos, indispensables para las organizaciones, permitiendo su crecimiento y supervivencia. El trabajo revisa los distintos tipos de legitimidad así como las estrategias que pueden seguir las organizaciones para ganar legitimidad, mantenerla y recuperarla.

  14. El lactato como posible factor del mecanismo de fatiga muscular.

    OpenAIRE

    José Carlos Giraldo T.; María Elena Sánchez

    2009-01-01

    Se revisa el papel del lactato en la función muscular. Se destacan los siguientes conceptos: el lactato es un intermediario metabólico que aumenta durante el ejercicio de alta intensidad, como consecuencia de la elevada actividad glicolítica. En esas condiciones la formación de ATP se asocia con generación de iones lactato e H+ y se reduce el pH de la célula activa. Si hay fatiga, el aumento en los niveles de lactato se correlaciona con la magnitud en la caída de la fuerza y los niveles de la...

  15. El federalismo cooperativo como factor catalizador de un Gobierno Abierto

    Directory of Open Access Journals (Sweden)

    Rafael Enrique Valenzuela Mendoza

    2013-01-01

    Full Text Available Este artículo tiene como propósito articular un marco de análisis que justifica la importancia de la colaboración entre gobiernos, bajo el supuesto de que un sistema rígido de competencias tiende a fragmentar la solución de los asuntos públicos en las agendas de gobierno. Un federalismo cooperativo, en tanto variable productora de relaciones intergubernamentales, da forma a un contexto que favorece impulsar soluciones más integrales en torno a demandas inscritas en el plan de acción, elaborado como requisito de pertenencia a la Alianza Internacional por un Gobierno Abierto. La propuesta llevada a Brasilia por la representación de México en junio de 2012, con la idea de promover la apertura gubernamental en el plano subnacional y local, tendrá mayores posibilidades de éxito si previamente se establecen bases mínimas para un federalismo cooperativo que facilite la gestión de los asuntos públicos establecidos en el plan de acción.

  16. Smoking and hyperlipidemia are important risk factors for coronary artery spasm

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Objective To investigate the role of coronary artery spasm in the etiology of chest pain lacking significant coronary stenosis and to identify the clinical risk factors related to coronary artery spasm. Methods Two hundred and seventy five patients with chest pain, but without significant coronary artery stenosis underwent the intracoronary acetylcholine test. Coronary artery spasm was diagnosed while coronary artery stenosis increased to 90% and was accompanied by the usual chest pain with or without ischemic changes on electrocardiogram. Logistic regression was employed to investigate the relationships between coronary artery spasm and sex, age, hypertension, diabetes mellitus, smoking, hyperlipidemia and results of electrocardiographic treadmill stress test. Left ventricular ejection fraction and end diastolic pressure were compared between spasm group and non-spasm group. Results Coronary artery spasm was detected in 103 out of 271 patients, a rate of 38%. Logistic regression analysis showed that smoking and hyperlipidemia increased the relative risk of coronary artery spasm 4.2 times and 2.3 times, respectively. There was a significantly negative relationship between diabetes mellitus and coronary artery spasm. Furthermore, there was no coronary artery spasm detected in left ventricular ejection fraction and end diastolic pressure. Conclusions Coronary artery spasm was one of the important etiological factors for patients with chest pain but no coronary artery stenosis. Smoking and hyperlipidemia were the main clinical risk factors for coronary artery spasm.

  17. Las bibliotecas como bien público: el factor humano

    OpenAIRE

    Pérez Iglesias, Javier

    1999-01-01

    This article discusses the benefits of the public library to the society. It exposes the necessity that libraries must offer quality and free public services. Public libraries are cultural institutions where the human factor is crucial.

  18. El trabajo nocturno como factor de riesgo psicosocial

    OpenAIRE

    Mongui Sánchez Hilda Margoth

    2010-01-01

    Las tendencias actuales de la promoción de la seguridad integral, la higiene y el bienestar en el trabajo ya no sólo tienen en cuenta los factores de riesgo tradicionales físicos, químicos, biológicos, ergonómicos y de inseguridad del ambiente laboral, sino otra serie de factores psicosociales inherentes al tipo de empresa, a la organización del trabajo y al clima organizacional que puedan influir sustancialmente en el bienestar físico mental y social del trabajador.

  19. El trabajo nocturno como factor de riesgo psicosocial

    Directory of Open Access Journals (Sweden)

    Mongui Sánchez Hilda Margoth

    1993-08-01

    Full Text Available

    Las tendencias actuales de la promoción de la seguridad integral, la higiene y el bienestar en el trabajo ya no sólo tienen en cuenta los factores de riesgo tradicionales físicos, químicos, biológicos, ergonómicos y de inseguridad del ambiente laboral, sino otra serie de factores psicosociales inherentes al tipo de empresa, a la organización del trabajo y al clima organizacional que puedan influir sustancialmente en el bienestar físico mental y social del trabajador.

  20. Lactancia materna como factor protector de la obesidad infantil y en edades futuras

    OpenAIRE

    González López, Tamara

    2016-01-01

    Introducción: la lactancia materna (LM) previene numerosas enfermedades, tanto del niño como de la madre, y previene la obesidad del niño, tanto en la infancia, como en las demás etapas de la vida. Objetivo: El objetivo de esta revisión sistemática es analizar el valor de la lactancia materna como factor protector frente al sobrepeso y la obesidad infantil y edades futuras. Método: Se ha efectuado una búsqueda sistemática y se han obtenido más de 100 documentos diferentes sobre el tema. Aplic...

  1. La innovación como factor de calidad en las organizaciones educativas

    Directory of Open Access Journals (Sweden)

    Ma. José Fernández Díaz

    2005-01-01

    Full Text Available En este artículo se analiza la innovación como factor fundamental de la calidad de las organizaciones educativas, tal y como se considera en los distintos modelos y sistemas de la calidad, como el EFQM. La relación y diferencias entre innovación y cambio así como las características fundamentales de los procesos de innovación permiten una mejor comprensión de los mismos. Las dificultades de implantación de acciones innovadoras en los centros y los factores o condiciones que los favorecen son objeto de especial interés para prestar especial atención a estos aspectos que están en la base de su éxito, profundizando en la importancia del liderazgo que impulsa los cambios y las innovaciones como uno de los principales requisitos. El uso de las TIC y las redes de profesionales como medios de formación y de innovación son dos elementos a destacar en los procesos innovadores en una sociedad del conocimiento.

  2. Arterial distensibility in adolescents: the influence of adiposity, the metabolic syndrome, and classic risk factors.

    OpenAIRE

    Whincup, P H; Gilg, J A; Donald, A E; Katterhorn, M.; Oliver, C.; Cook, D.G.; Deanfield, J E

    2005-01-01

    BACKGROUND: Atherosclerosis develops from childhood, but the determinants of this preclinical stage remain uncertain. We examined the relations of classic coronary risk factors, adiposity and its associated metabolic disturbances, to arterial distensibility (a marker of early arterial disease) in 13- to 15-year-olds, some of whom had previously been studied at ages 9 to 11 years. METHODS AND RESULTS: Brachial artery distensibility was measured by a noninvasive ultrasound technique in 471 Brit...

  3. Risk Factors for Vertebral Artery Injuries in Cervical Spine Trauma

    OpenAIRE

    Harshavardhana, Nanjundappa S.; Harshad V. Dabke

    2014-01-01

    Blunt cerebrovascular injuries (i.e. involvement of carotid and vertebral arteries) are increasingly being recognized in setting of cervical spine trauma/fractures and are associated with high incidence of stroke/morbidity and mortality. The incidence of vertebral artery injuries (VAI) is more common than previously thought and regular screening is seldom performed. However there exists no screening criteria and conflicting reports exists between spine and trauma literature. Many clinicians d...

  4. Risk factors for vertebral artery injuries in cervical spine trauma

    OpenAIRE

    Harshavardhana, Nanjundappa S.; Harshad V. Dabke

    2014-01-01

    Blunt cerebrovascular injuries (i.e. involvement of carotid and vertebral arteries) are increasingly being recognized in setting of cervical spine trauma/fractures and are associated with high incidence of stroke/morbidity and mortality. The incidence of vertebral artery injuries (VAI) is more common than previously thought and regular screening is seldom performed. However there exists no screening criteria and conflicting reports exists between spine and trauma literature. Many clinicians d...

  5. A Inteligência Emocional como factor de sucesso na actividade policial

    OpenAIRE

    Pinto, Mário

    2009-01-01

    A presente investigação subordinada ao tema “A inteligência emocional como factor de sucesso na actividade policial”, tem como objectivo analisar a relação entre a inteligência emocional, as competências emocionais e o stresse ocupacional. Constitui igualmente, objectivo deste trabalho estudar as diferenças entre estas variáveis em função da Actividade Operacional e do tempo de serviço. Para a análise da inteligência emocional foi utilizada a escala de Inteli...

  6. Effect of Cardio-Metabolic Risk Factors Clustering with or without Arterial Hypertension on Arterial Stiffness: A Narrative Review

    Directory of Open Access Journals (Sweden)

    Vasilios G. Athyros

    2013-11-01

    Full Text Available The clustering of cardio-metabolic risk factors, either when called metabolic syndrome (MetS or not, substantially increases the risk of cardiovascular disease (CVD and causes mortality. One of the possible mechanisms for this clustering's adverse effect is an increase in arterial stiffness (AS, and in high central aortic blood pressure (CABP, which are significant and independent CVD risk factors. Arterial hypertension was connected to AS long ago; however, other MetS components (obesity, dyslipidaemia, dysglycaemia or MetS associated abnormalities not included in MetS diagnostic criteria (renal dysfunction, hyperuricaemia, hypercoaglutability, menopause, non alcoholic fatty liver disease, and obstructive sleep apnea have been implicated too. We discuss the evidence connecting these cardio-metabolic risk factors, which negatively affect AS and finally increase CVD risk. Furthermore, we discuss the impact of possible lifestyle and pharmacological interventions on all these cardio-metabolic risk factors, in an effort to reduce CVD risk and identify features that should be taken into consideration when treating MetS patients with or without arterial hypertension.

  7. Tabaco y diabetes como factores de riesgo de enfermedades no transmisibles

    Directory of Open Access Journals (Sweden)

    Maria de la Caridad Casanova Moreno

    2014-10-01

    Full Text Available Sr. Editor: La tendencia actual en cuanto a las enfermedades no transmisibles y en especial a la diabetes mellitus se dirige a manejar el estado general del sujeto, donde el riesgo vascular ocupa un lugar importante para el control de la enfermedad, así como el aumento de peso, entre otros. En este tema, resulta muy importante la divulgación del artículo publicado en el Vol. 39, número 8 de agosto de 2014, titulado: Incidencia de factores de riesgo y modalidades de enfermedad ateroesclerótica en pacientes de Puerto Padre en el periodo comprendido entre mayo de 2012 y junio de 2013, donde se encontró que los factores de riesgo de enfermedad ateroesclerótica más incidentes fueron el hábito de fumar, la hipertensión arterial, la diabetes mellitus y la obesidad. La diabetes mellitus (DM se ha convertido en un creciente problema de salud en el mundo. Ahora se sabe que fumar causa diabetes tipo 2 (DM2, también conocida como la diabetes del adulto. Los fumadores tienen entre el 30 y el 40 % más de probabilidades de tener DM2 que los no fumadores. Mientras más cigarrillos fume una persona, más alto es su riesgo de DM. La DM puede producir complicaciones de salud graves como las enfermedades cardiacas, la ceguera, la insuficiencia renal y el daño en los nervios y los vasos sanguíneos de los pies y las piernas, lo cual puede llevar a situaciones como la amputación. Una persona con DM que fuma tiene más probabilidades de tener dificultad para regular la insulina y controlar la enfermedad que las personas con diabetes que no fuman. Tanto el tabaquismo como la diabetes causan problemas con el flujo de la sangre. Esto eleva el riesgo de ceguera y amputación. Los fumadores con DM, además, tienen más probabilidades de tener insuficiencia renal que las personas con diabetes que no fuman. (1 En Cuba la prevalencia de DM para el año 2013 fue de 53,7 x 1 000 habitantes., valor que aumentó con la edad, siendo para esta enfermedad los años de

  8. 78. Environmental air pollution: A new emerging factor for coronary artery disease

    Directory of Open Access Journals (Sweden)

    S.A. Meo

    2016-07-01

    Conclusion: Environmental pollution exert detrimental effects on the heart. The researchers and physicians must consider the environmental pollution as an emerging factor in the development of coronary artery disease.

  9. Association between corneal arcus and some of the risk factors for coronary artery disease.

    OpenAIRE

    Pe'er, J; Vidaurri, J.; Halfon, S. T.; Eisenberg, S; Zauberman, H

    1983-01-01

    The relationships between coronary artery disease risk factors and corneal arcus were examined in 150 adults aged 55 years and above of both sexes and from different ethnic origins. The width of the corneal arcus was measured accurately by a digitiser, and the risk factors for coronary artery disease were examined according to the standard procedure used by the Lipid Research Clinics. The results show that the corneal arcus is more frequent in males; the frequency and size of corneal arcus ar...

  10. Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle

    OpenAIRE

    Hartman, William; Helan, Martin; Smelter, Dan; Sathish, Venkatachalem; Thompson, Michael; Pabelick, Christina M.; Johnson, Bruce; Y S Prakash

    2015-01-01

    Background Hypoxia effects on pulmonary artery structure and function are key to diseases such as pulmonary hypertension. Recent studies suggest that growth factors called neurotrophins, particularly brain-derived neurotrophic factor (BDNF), can influence lung structure and function, and their role in the pulmonary artery warrants further investigation. In this study, we examined the effect of hypoxia on BDNF in humans, and the influence of hypoxia-enhanced BDNF expression and signaling in hu...

  11. Factors associated with failure to identify the culprit artery by the electrocardiogram in inferior ST-elevation myocardial infarction

    DEFF Research Database (Denmark)

    Tahvanainen, Minna; Nikus, Kjell C; Holmvang, Lene;

    2011-01-01

    Right and left circumflex coronary artery occlusions cause inferior myocardial infarction. To improve the targeting of diagnostic and therapeutic measures individually, factors interfering with identification of the culprit artery by the electrocardiogram (ECG) were explored....

  12. Importancia de los acontecimientos vitales como factores de cambio en el ciclo vital

    OpenAIRE

    Melero Marcos, Luis; Ventola Barrado, María Luisa I.

    1995-01-01

    RESUMEN: A lo largo del ciclo vital, los individuos experimentan una serie de acontecimientos que, sin duda, influyen en su desarrollo individual y colectivo. Tales acontecimientos parecen introducir cambios en la vida de los sujetos. El presente trabajo pretende analizar la importancia de los acontecimientos vitales como factores de cambio, desde la consideración de que el estudio de los mismos es consustancial con el estudio del ciclo vital. Desde este punto de partida, se ha establecido la...

  13. Prevalence Pattern of Risk Factors for Coronary Artery Disease among Patients Presenting for Coronary Artery Bypass Grafting in Oman

    Directory of Open Access Journals (Sweden)

    Rajeeva Rivikath Pieris

    2014-05-01

    Full Text Available Objectives: To identify the pattern of prevalence of risk factors in patients presenting for coronary artery bypass grafting at a single center in Oman. Methods: All patients who had coronary artery bypass grafting between March 2008 to March 2010 were included and data were obtained from history and laboratory investigations. The prevalence rates of eight conventional risk factors are presented as a retrospective single center observational study. Results: Out of 146 total patients, 107 (73.29% were male. The age ranged from 31 to 87 years old. The mean age was 58.18 ± 10.08 years (males = 56.81 ± 10.42, females = 61.95 ± 7.97. Hypertension was present in 119 patients (81.51%, 115 patients (78.77% had dyslipidemia, 107 patients (73.29% were male, 79 patients (54.11% had diabetes mellitus, 70 patients (47.95% were over the age of 60 years, 41 patients (28.08% gave a history of smoking, 31 patients (21.23% were obese, and 19 patients (13.01% gave a positive family history. Conclusions: The most common risk factor was hypertension, followed by dyslipidemia, male gender, diabetes mellitus, old age, smoking, obesity and positive family history; 87.7% had three or more risk factors. The females in this study were older than the males and had more risk factors at presentation. The most common combination of factors seen together was diabetes, hypertension, dyslipidemia and male gender.

  14. Influential factors and formation of extrahepatic collateral artery in unresectable hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Yong-Li Wang; Ming-Hua Li; Ying-Sheng Cheng; Hai-Bing Shi; Hai-Lun Fan

    2005-01-01

    AIM: To analyze the influence factors and formation of extrahepatic collateral arteries (ECAs) in unresectable hepatocellular carcinoma (HCC) with or without chemoembolization.METHODS: Detailed histories of 35 patients with 39 ECAs of HCC and images including computerized tomography scan, digital subtraction angiography were reviewed carefully to identify ECAs of HCC, ECAs arising from, and anatomic location of tumors in liver. Tumor sizes were measured, and relations of EC As with times of chemoembolization, tumor size, and the anatomic tumor location were analyzed. Complications were observed after chemoembolization through ECAs of HCC with different techniques. RESULTS: Influence factors of formation of ECAs of HCC included the times of repeated chemoembolization, thelocation of tumors in liver, the tumor size and the types of chemoembolization. ECAs in HCC appeared after 3-4 times of chemoembolization (17.9%), but a higher frequency of ECAs occurred after 5-6 times of chemoembolization (56.4%). ECAs presented easily in peripheral areas (71.8%) of liver abutting to the anterior, posterior abdominal walls, the top right of diaphragm and right kidney.ECAs also occurred easily after complete obstruction of the trunk arteries supplying HCCs or the branches of proper hepatic arteries. Extrahepatic collaterals of HCC originated from right internal thoracic (mammary) artery (RITA, 5.1%), right intercostal artery (RICA, 7.7%), left gastric artery (LGA, 12.8%), right inferior phrenic artery (RIPA, 38.5%),omental artery (OTA, 2.6%), superior mesenteric artery (SMA, 23.1%), and right adrenal and renal capsule artery (RARCA, 10.3%), respectively. The complications after chemoembolization attributed to no super selective cathet erization.CONCLUSION: The formation of ECAs in unresectable HCCis obviously correlated with multiple chemoembolization,tumor size, types of chemoembolization, anatomic locationof tumors. Extrahepatic collaterals in HCC are corresponding to the tumor

  15. LA INFLAMACIÓN COMO FACTOR CAUSAL EMERGENTE DE LA ENFERMEDAD CARDIOVASCULAR

    Directory of Open Access Journals (Sweden)

    T. Fernández-Mora

    2007-06-01

    Full Text Available La ateroesclerosis está involucrada en el desarrollo de la enfermedad cardiovascular, una de las principales enfermedades de morbimortalidad en el mundo. Se han determinado una serie de factores de riesgo, tanto clásicos como emergentes, implicados en el desarrollo de esta enfermedad. Recientes investigaciones han demostrado que la inflamación juega un papel clave en el desarrollo de la ateroesclerosis. Las células del sistema inmune se encuentran presentes en todos los estadios de las lesiones arterioescleróticasy sus moléculas efectoras pueden acelerar la progresión de las lesiones y orquestar los mecanismos de inflamación inducidos en los síndromes coronarios agudos. La evidencia crítica implica a mediadores de la inmunidad tanto innata como adquirida en los diferentes estados de la ateroesclerosis. Dentro de loscomponentes inmunes involucrados en el proceso de la ateroesclerosis se encuentran componentes celulares como macrófagos, linfocitos, células dendríticas, mastocitos, células NK; componentes humoralescomo anticuerpos, citocinas proinflamatorias y moduladoras de la respuesta inmune, complemento, proteínas de fase aguda; y otros componentes como moléculas de adhesión y de choque térmico. A partirdel esclarecimiento del papel del sistema inmune en el desarrollo de la arterioesclerosis, han surgido una serie de perspectivas diagnósticas y terapéuticas para la enfermedad cardiovascular.

  16. Factors influencing delay time and coronary arterial density during coronary angiography with DSCT

    International Nuclear Information System (INIS)

    Background: CT angiography (CTA) plays an important role in diagnosing coronary arterial disease. Delay time and density of the coronary arteries related with patient-specific factors are essential for getting an optimal CTA image. Purpose: To investigate various factors influencing delay time and coronary arterial density during coronary CTA with dual source CT. Material and Methods: One hundred and sixteen consecutive subjects who underwent cardiac DSCT with retrospective ECG-gating were included. Factors including gender, age, height, weight, transversal cardiac diameter (TCD), transversal thoracic diameter (TTD), heart rate (HR), body surface area (BSA = [weight x height/3600]1/2) and cardiothoracic ratio (CTR = TCD/TTD) were recorded, measured and calculated before administration of contrast media during coronary CT angiography. Delay time was determined as duration from the beginning of the injection to the density in the descending aorta at the level of right main pulmonary artery reaching a threshold of 100 HU. Coronary arterial density was measured at the mid portion of the right coronary artery. Regression analysis and stepwise regression analysis were used to investigate the influence of these factors on delay time and coronary arterial density. Results: Delay time decreased with an increasing HR and it was shorter in women than men. Delay time increased with an increasing TCD. Delay time could be predicted by the formula: DT = 16.651-0.110 x HR + 1.902 x gender + 0.394 x TCD (where DT is abbreviation for delay time, gender is 0 for women and 1 for men). Coronary arterial density decreased with an increasing HR and weight. Coronary arterial density could be predicted by the formula: CAD = 923.42-4.099 x HR-3.293 x weight (CAD = coronary arterial density). There was no relationship between the other factors mentioned above and delay time or coronary arterial density. Conclusion: Delay time is influenced by HR, gender and TCD. Coronary arterial density

  17. Risk Factors for Vertebral Artery Injuries in Cervical Spine Trauma

    Science.gov (United States)

    Dabke, Harshad V.

    2014-01-01

    Blunt cerebrovascular injuries (i.e. involvement of carotid and vertebral arteries) are increasingly being recognized in setting of cervical spine trauma/fractures and are associated with high incidence of stroke/morbidity and mortality. The incidence of vertebral artery injuries (VAI) is more common than previously thought and regular screening is seldom performed. However there exists no screening criteria and conflicting reports exists between spine and trauma literature. Many clinicians do not routinely screen/evaluate patients presenting with cervical spine trauma for potential VAI. This article provides a brief summary of existing evidence regarding the incidence of VAI in the background of cervical trauma/fractures. The type and fracture pattern that is associated with a high risk of VAI warranting mandatory screening/further work-up is discussed. A brief overview of diagnostic modalities and their respective sensitivity/specificity along with available treatment options is also summarized. PMID:25317310

  18. Risk factors for vertebral artery injuries in cervical spine trauma

    Directory of Open Access Journals (Sweden)

    Nanjundappa S. Harshavardhana

    2014-10-01

    Full Text Available Blunt cerebrovascular injuries (i.e. involvement of carotid and vertebral arteries are increasingly being recognized in setting of cervical spine trauma/fractures and are associated with high incidence of stroke/morbidity and mortality. The incidence of vertebral artery injuries (VAI is more common than previously thought and regular screening is seldom performed. However there exists no screening criteria and conflicting reports exists between spine and trauma literature. Many clinicians do not routinely screen/evaluate patients presenting with cervical spine trauma for potential VAI. This article provides a brief summary of existing evidence regarding the incidence of VAI in the background of cervical trauma/fractures. The type and fracture pattern that is associated with a high risk of VAI warranting mandatory screening/further work-up is discussed. A brief overview of diagnostic modalities and their respective sensitivity/specificity along with available treatment options is also summarized.

  19. Diseños de Piezas en CAD como Factor de la Flexibilidad en un CIM

    OpenAIRE

    Ángel David Jinéz Bernal; Reyes Hernández Díaz

    2005-01-01

    En los Sistemas de Manufactura Integrados por Computadora se hace hincapié cada vez más en la flexibilidad por ser un requisito indispensable para que la industria que lo implemente tenga competitividad, entonces, existen muchos factores que limitan esta cualidad y que exigen en estos tiempos hacer investigaciones que encuentren estos factores, para así poder idear como evitarlos o controlarlos en alguna medida. Es aquí donde se pensó si el tamaño de las familias de...

  20. Tecnología como factor de innovación en empresas colombianas

    OpenAIRE

    John Edisson Londoño Rua

    2015-01-01

    El desarrollo de innovaciones depende de múltiples factores para lograr consolidar procesos exitosos que parten de la definición de una estrategia adecuada. Uno de los factores importantes es la tecnología dado que contribuye al logro de los resultados empresariales propuestos, por tanto, el objetivo del presente trabajo consiste en verificar si la adquisición de tecnologías de información genera beneficios en innovación para las empresas colombianas; así mismo, se analiza su importancia como...

  1. Association of carotid artery intima-media thickness and cardiovascular risk factors in adult

    International Nuclear Information System (INIS)

    Increased intima-media thickness (IMT) of the common carotid artery is an early marker of atherosclerosis and a powerful predictor of coronary and cerebrovascular diseases. The purpose of this study was to evaluate the correlation between carotid artery IMT and cardiovascular risk factors. Total 134 adult were performed with Ultrasonography to measure IMT at common carotid artery, the physical measurements and blood tests, the following results were obtained. As a result, IMT showed higher value in male IMT than female IMT. And, the IMT increased according to the age increased. Also, TC and AI have positive significant correlation with IMT. In Conclusion, cardiovascular risk factors with adult are associated with increased IMT of common carotid artery

  2. Association of carotid artery intima-media thickness and cardiovascular risk factors in adult

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Mi Young [Dept. of Diagnostic Radiology, Dankook University Hospital, Cheonan (Korea, Republic of); Kim, Hwa Sun [Dept. of Radiological Technology, Ansan University, Ansan (Korea, Republic of); Kim, Shin Young [Dept. of Anatomy and Cell Biology, School of Medicine, Hanyang University, Seoul (Korea, Republic of)

    2013-03-15

    Increased intima-media thickness (IMT) of the common carotid artery is an early marker of atherosclerosis and a powerful predictor of coronary and cerebrovascular diseases. The purpose of this study was to evaluate the correlation between carotid artery IMT and cardiovascular risk factors. Total 134 adult were performed with Ultrasonography to measure IMT at common carotid artery, the physical measurements and blood tests, the following results were obtained. As a result, IMT showed higher value in male IMT than female IMT. And, the IMT increased according to the age increased. Also, TC and AI have positive significant correlation with IMT. In Conclusion, cardiovascular risk factors with adult are associated with increased IMT of common carotid artery.

  3. Factores relacionados con el descontrol de la presión arterial Factors associated with uncontrolled hypertension

    Directory of Open Access Journals (Sweden)

    Oliva Mejía-Rodríguez

    2009-08-01

    Full Text Available OBJETIVO: Evaluar las características de la atención del paciente hipertenso, y su relación con el descontrol de la presión arterial, en una unidad de medicina familiar. MATERIAL Y MÉTODOS: Diseño: estudio transversal. Se revisó la mitad de 8 080 (4 040 expedientes. Se registraron las características de los pacientes, los médicos tratantes y la unidad de atención. RESULTADOS: Se encontraron como factores asociados a la hipertensión descontrolada la edad (RM, 1.43; IC95%: 1.015-1.030, IMC (RM, 1.03; IC95%: 1.02-1.05, creatinina (RM, 1.16; IC95%: 1.03-1.30, tomar tres o más fármacos antihipertensivos (RM, 1.48; IC95%: 1.31-1.07, ser atendido por un médico con más de 20 años de antigüedad (RM, 1.21; IC95%: 1.06-1.39, sin especialidad (RM, 1.43; IC95%: 1.20-1.71 y ser atendido en el turno matutino (RM, 1.21; IC95%: 1.07-1.56. CONCLUSIONES: La presión arterial está bien controlada en la mayoría de los pacientes. En el descontrol de la presión arterial intervienen factores relacionados con el paciente mismo, pero las características del sistema de salud también tienen un papel significativo.OBJECTIVE: To assess health care characteristics for hypertensive patients and their association with uncontrolled hypertension in a primary care outpatient clinic. MATERIAL AND METHODS: Design: cross-sectional.A review was conducted of 50% of 8080 (n= 4040 files. Patient, physician and primary health care clinic characteristics were recorded. RESULTS: The factors associated with uncontrolled hypertension were: age (OR, 1.43; CI95% : 1.015-1.030, BMI (OR, 1.03; CI95%: 1.02-1.05, creatinine serum levels (OR, 1.16; CI95%: 1.03-1.30, three or more different antihypertensive drugs (OR, 1.48; CI95%: 1.31-1.07, to be treated by a physician with more than 20 years of medical practice (OR, 1.21; CI95%; 1.06-1.39 or by a non-specialist physician (OR, 1.43; CI95%: 1.20-1.71 and to be treated in the morningshift (OR, 1.21; CI95%: 1.07- 1.56. CONCLUSIONS

  4. Importancia de los acontecimientos vitales como factores de cambio en el ciclo vital

    Directory of Open Access Journals (Sweden)

    Luis MELERO MARCOS

    2009-11-01

    Full Text Available RESUMEN: A lo largo del ciclo vital, los individuos experimentan una serie de acontecimientos que, sin duda, influyen en su desarrollo individual y colectivo. Tales acontecimientos parecen introducir cambios en la vida de los sujetos. El presente trabajo pretende analizar la importancia de los acontecimientos vitales como factores de cambio, desde la consideración de que el estudio de los mismos es consustancial con el estudio del ciclo vital. Desde este punto de partida, se ha establecido la existencia de diversos tipos de clasificaciones de acontecimientos, como la aportada por Rodrigo (1985, que plantea la existencia de tres tipos de eventos, eventos normativos relacionados con la edad, eventos normativos relacionados con el tiempo histórico, y finalmente, un tercer tipo de acontecimientos considerados como no normativos, que solamente son experimentados por algunos sujetos a lo largo de su vida. Analizaremos aquellos factores que adquieren significado en el desarrollo de los acontecimientos vitales y en la forma como los perciben los individuos que los experimentan, desde la revisión de los principales modelos explicativos, polarizados en dos grandes paradigmas, organicista y mecanicista, así como el intento de aproximación a través de modelos contextúales-dialécticos a una posición intermedia entre el paradigma organicista y el paradigma mecanicista.ABSTRACT: Throughout the vital cycle, individuals undergo experiences which no doubt exert an influence on their development. The present article analyzes the importance of vital events as change factors. We assume their inseparability. Adopting the classification established by Rodrigo (1985 we distinguish three classes of events, namely, normative events related to age, normative events related to historical time and non normative events which are not universally experienced by all subjects. We will analyze those factors which have relevant meaning in the development of vital events

  5. Estabilidad emocional y cortisol como factores diferenciadores de la fibromialgia Emotional stability and cortisol as differentiating factors for fibromyalgia

    OpenAIRE

    L.A. Díaz Robredo; J.I. Robles Sánchez

    2011-01-01

    Este estudio busca un acercamiento al diagnóstico de la fibromialgia desde un modelo psicofisiológico del estrés. En la Introducción justificaremos los principios teóricos en que se basa este trabajo. Las hipótesis planteadas intentarán buscar la diferencia de factores psicológicos y de cortisol entre los grupos control y experimental, así como la correlación entre dichos factores. En el apartado Materiales y métodos nos centramos en los registros de cortisol y de variables de personalidad qu...

  6. Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities

    OpenAIRE

    Wardlaw, Joanna M; Allerhand, Michael; Doubal, Fergus N; Valdes Hernandez, Maria; Morris, Zoe; Gow, Alan J; Bastin, Mark; John M Starr; Dennis, Martin S.; Deary, Ian J.

    2014-01-01

    OBJECTIVE: To determine the magnitude of potentially causal relationships among vascular risk factors (VRFs), large-artery atheromatous disease (LAD), and cerebral white matter hyperintensities (WMH) in 2 prospective cohorts.METHODS: We assessed VRFs (history and measured variables), LAD (in carotid, coronary, and leg arteries), and WMH (on structural MRI, visual scores and volume) in: (a) community-dwelling older subjects of the Lothian Birth Cohort 1936, and (b) patients with recent nondisa...

  7. Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities

    OpenAIRE

    Wardlaw, Joanna M; Allerhand, Michael; Doubal, Fergus N; Valdes Hernandez, Maria; Morris, Zoe; Gow, Alan J; Bastin, Mark; John M Starr; Dennis, Martin S.; Deary, Ian J.

    2014-01-01

    Objective: To determine the magnitude of potentially causal relationships among vascular risk factors (VRFs), large-artery atheromatous disease (LAD), and cerebral white matter hyperintensities (WMH) in 2 prospective cohorts. Methods: We assessed VRFs (history and measured variables), LAD (in carotid, coronary, and leg arteries), and WMH (on structural MRI, visual scores and volume) in: (a) community-dwelling older subjects of the Lothian Birth Cohort 1936, and (b) patients with recent nondis...

  8. The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population

    OpenAIRE

    Vicheto Marisa; Sorribes Marta; Toran Pere; Pera Guillem; Baena-Díez José; Forés Rosa; Alzamora María; Reina María; Sancho Amparo; Albaladejo Carlos; Llussà Judith

    2010-01-01

    Abstract Background The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index is a good marker of vascular events and may be diminished without presenting symptomatology (silent peripheral arterial disease). The aim of the study is to know the prevalence and associated risk factors of peripheral arterial disease in the general population. Methods We perfo...

  9. Experience of cardiac rehabilitation after coronary artery surgery: effects on health and risk factors

    OpenAIRE

    Lindsay, G.; Hanlon, W.P; Smith, L.N.; Belcher, P.R.

    2003-01-01

    Objective:Cardiac rehabilitation (CR) programs are provided to support the recovery process following acute myocardial infarction and coronary artery bypass grafting (CABG). Attendance varies. We related attendance following CABG to severity of cardiac symptoms, general health status (Short Form-36) and prevalence of modifiable coronary artery disease (CAD) risk factors. METHODS: 209 patients due to undergo CABG were recruited and assessed preoperatively as well as at a mean of 16.4 months po...

  10. Tabaco y diabetes como factores de riesgo de enfermedades no transmisibles

    OpenAIRE

    Maria de la Caridad Casanova Moreno; Maricela Trasancos Delgado

    2014-01-01

    Sr. Editor: La tendencia actual en cuanto a las enfermedades no transmisibles y en especial a la diabetes mellitus se dirige a manejar el estado general del sujeto, donde el riesgo vascular ocupa un lugar importante para el control de la enfermedad, así como el aumento de peso, entre otros. En este tema, resulta muy importante la divulgación del artículo publicado en el Vol. 39, número 8 de agosto de 2014, titulado: Incidencia de factores de riesgo y modalidades de enfermedad ateroes...

  11. La autoestima como factor estresor intrapersonal para el consumo de alcohol en trabajadoras sexuales

    OpenAIRE

    Salinas Almaguer, Claudia Erika; Padilla Raygoza, Nicolás; Ruiz Paloalto, María Laura; Vera Ramírez, Ana María

    2014-01-01

    Introducción. El alcoholismo es un problema mundial de salud y en las mujeres consumidoras se está incrementando. El sexo servicio podría estar ligado al consumo de alcohol. Objetivo. Medir la relación entre autoestima como factor estresor intrapersonal y el consumo de alcohol en las trabajadoras sexuales. Material y métodos. Estudio aprobado por el Comité de Investigación. Estudio transversal analítico en sexoservidoras en Cosoleacaque, Veracruz. Para consumo de alcohol se utilizó el c...

  12. La autoestima como factor estresor intrapersonal para el consumo de alcohol en trabajadoras sexuales

    OpenAIRE

    Claudia Erika Salinas Almaguer; Nicolás Padilla Raygoza; Mª Laura Ruiz Paloalto; Ana Mª Vera Ramírez

    2014-01-01

    Introducción. El alcoholismo es un problema mundial de salud y en las mujeres consumid oras se está incrementando. El sexo servicio podría estar ligado al consumo de alcohol. Objetivo. Medir la relación entre autoestima como factor estresor intrapersonal y el consumo de alcohol en las trabajadoras sexuales. Material y métodos. Estudio ap robado por el Comité de Investigación. Estudio transversal analítico en sexoservidoras en Cosoleacaque, Veracruz. Para consumo de alcohol se utilizó el cuest...

  13. Periodontitis as a Risk Factor in Non-Diabetic Patients with Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Vida Nesar Hoseini

    2010-11-01

    Full Text Available Coronary Artery Disease (CAD is responsible for much mortality across the w orld, especially in our country .The conventional risk factors for atherosclerosis are well understood, but they can account for only about 50 to 70% of atherosclerotic events in the general population. The aim of this study was to investigate relationships between prevalent Coronary Artery Disease (CAD and clinical periodontal disease in patients with angiographic ally proven coronary artery disease. 152 consecutive patients w ith angiographically proven coronary artery disease will be included in this study, who received a complete periodontal examination during visit. Patients with normal coronary, average plaque index (1.6±1.02 Index of bleeding (1.51±0.92, mean adhesion level (3.57±1.18. But patients with coronary artery disease, the mean plaque index (2.46±0.62 Index of bleeding (1.86±0.92, mean adhesion level (4.13±1.45. These differences are statistically significant. (p<0.05 In this study, average depth of probe entrance on the surface of teeth has had little relation w ith cardiovascular disease (p = 0.051. According to the results of this study, in peoples over 40 years, who had coronary artery disease proved by coronary angiography, gingival inflammation (periodentitis has a significant relation as a risk factor.

  14. High-sensitive factor I and C-reactive protein based biomarkers for coronary artery disease

    OpenAIRE

    Zhao, Qing; Du, Jian-Shi; Han, Dong-Mei; Ma, Ying

    2014-01-01

    An analysis of high-sensitive factor I and C-reactive proteins as biomarkers for coronary artery disease has been performed from 19 anticipated cohort studies that included 21,567 participants having no information about coronary artery disease. Besides, the clinical implications of statin therapy initiated due to assessment of factor I and C-reactive proteins have also been modeled during studies. The measure of risk discrimination (C-index) was increased (by 0.0101) as per the prognostic mo...

  15. El turismo cultural como factor estratégico de desarrollo: el Camino de Santiago

    Directory of Open Access Journals (Sweden)

    Precedo Ledo, Andrés

    2007-06-01

    Full Text Available The objective of this investigation is to study one of the strategies of territorial marketing of greater success: the promotion of the Way of Santiago and the mark of the Xacobeo. The approach of the study attack from the perspective of its contribution to the territorial, as much rural development (the Galician section of the Way like urban (the city of Santiago de Compostela. The departure hypothesis is that, in both cases, the cultural tourism has worked like a complementary factor of development being necessary to insert it in a model of integrated development to optimize its potential of share capital.

    El objetivo de esta investigación es estudiar una de las estrategias de marketing territorial de mayor éxito: la promoción del Camino de Santiago y la marca del Xacobeo. El enfoque del estudio se aborda desde la perspectiva de su contribución al desarrollo territorial, tanto rural (el tramo gallego del Camino como urbano (la ciudad de Santiago de Compostela. La hipótesis de partida es que, en ambos casos, el turismo cultural ha funcionado como un factor complementario de desarrollo siendo necesario insertarlo en un modelo de desarrollo integrado para optimizar su potencial de capital social.

  16. Tecnología como factor de innovación en empresas colombianas

    Directory of Open Access Journals (Sweden)

    John Edisson Londoño Rua

    2015-01-01

    Full Text Available El desarrollo de innovaciones depende de múltiples factores para lograr consolidar procesos exitosos que parten de la definición de una estrategia adecuada. Uno de los factores importantes es la tecnología dado que contribuye al logro de los resultados empresariales propuestos, por tanto, el objetivo del presente trabajo consiste en verificar si la adquisición de tecnologías de información genera beneficios en innovación para las empresas colombianas; así mismo, se analiza su importancia como insumo para la definición de la estrategia organizacional. Para ello se hizo un ejercicio de correlación estadística entre las variables de adquisición de tecnología e Innovación con elementos de la II Encuesta de Desarrollo e Innovación Tecnológica en Colombia, indicando si existe dependencia entre resultados de las variables. Como principal conclusión se tiene que en Colombia la adquisición de tecnología no es parte activa de la estrategia organizacional, o su uso se ha orientado hacia actividades que no generan ventaja competitiva. Mediante este estudio se pretende contribuir al desarrollo del proceso de gestión en las empresas del país.

  17. Affecting Factors of Arterial Stiffness in Living Related Kidney Transplant Recipients

    Directory of Open Access Journals (Sweden)

    Serpil Ergülü EŞMEN

    2011-05-01

    Full Text Available Arterial stiffness might be affected by several factors including recipient as well as donors. In this study, we aimed to evaluate arterial stiffness in living related kidney transplant recipients before and after transplantation. We enrolled 47 living related kidney recipients and pulse wave velocity (PWV was determined before and after transplantation. Donor renal arterial biopsy, recipient iliac artery samples were taken during the operation and PWV was also determined for the donors. Forty-seven patients completed the study. Post-transplantation follow-up duration was 18.5±5.7 months. Before transplantation, the mean PWV 8.1±1.4 m/sec and it was 7.5±2.0 m/sec after the transplantation (p=0.014. The patients were divided into two groups as with (30 patients and without (17 patients a PWV decrease. Recipient age, gender, CRP, PTH, lipids, and blood pressures were not significantly different between the groups. The recipient body mass index was higher in patients with a PWV decrease. Donor-related factors were not different between the groups. We found that blood pressure and LDL cholesterol levels in recipients were associated with a decrease in PWV after the transplantation. In conclusion, donor-related factors do not seem to have an impact on arterial stiffness in recipients. Pretransplant BMI and posttransplant blood pressure and LDL cholesterol levels were associated with a decrease in PWV.

  18. Diseños de Piezas en CAD como Factor de la Flexibilidad en un CIM

    Directory of Open Access Journals (Sweden)

    Ángel David Jinéz Bernal

    2005-01-01

    Full Text Available En los Sistemas de Manufactura Integrados por Computadora se hace hincapié cada vez más en la flexibilidad por ser un requisito indispensable para que la industria que lo implemente tenga competitividad, entonces, existen muchos factores que limitan esta cualidad y que exigen en estos tiempos hacer investigaciones que encuentren estos factores, para así poder idear como evitarlos o controlarlos en alguna medida. Es aquí donde se pensó si el tamaño de las familias de piezas diseñadas por computadora (CAD, pudieran tener correlación con el nivel de flexibilidad del sistema de manufactura integrado por computadora, ya que existe información de que no se tiene ningún control en la elaboración de estos dibujos, o sea que se crean sólo por que es muy fácil modificarlos, y el tamaño de las familias no está estandarizado. Como la variable “familias de piezas” es cuantitativa y “nivel de flexibilidad” es cualitativa, se utilizó otra variable cuantitativa como auxiliar en la realización del análisis: el “volumen de producción”. Entonces, mediante regresión simple, se observó que estas variables sí tienen una fuerte relación estadística significativa. Se aplicaron las técnicas estadísticas necesarias para comprobar que el modelo lineal es el más adecuado y se llegó a la conclusión de que sí es el modelo que más se ajusta a los datos. Por lo tanto, como sí existe relación entre las variables cuantitativas (Variedad y volumen, se encontró que el tamaño de las familias de piezas sí afecta el nivel de flexibilidad de los Sistemas de Manufactura Integrados por Computadora

  19. Factors associated with breast arterial calcification on mammography

    International Nuclear Information System (INIS)

    Objective: To determine the frequency of breast arterial calcifications (BAC) as seen on mammographic examination and to determine the association between BAC and hypertension, age, parity and weight of the person. Study Design: Cross-sectional analytic study. Place and Duration of Study: Department of Diagnostic Radiology, Military Hospital, Rawalpindi, from January 2006 to January 2007. Methodology: Two hundred patients undergoing mammography were studied to evaluate the association of BAC with raised blood pressure, age and parity. Previous history of lactation and the patients' weight were also recorded. Proportions of classes were compared using chi-square test. Results: 13.5% of the subjects (n = 200) were positive for BAC on mammograms. Mean age of the BAC positive subjects was higher than their counterparts found negative for BAC. Women bearing 5 - 6 children showed the highest frequency of BAC. Seventy seven (10.38%) of the BAC positive cases had previous history of lactation, whereas 15.44% (n = 123) had not breast fed their children and showed BAC. No significant association of presence of BAC was noted with the weight of the subjects. Conclusion: The frequency of presence of BAC on mammography was associated with systemic hypertension and higher age. It also increased with the reproductive parameters of a woman. (author)

  20. Cocoa intake and arterial stiffness in subjects with cardiovascular risk factors

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    Recio-Rodríguez José

    2012-02-01

    Full Text Available Abstract Background To analyze the relationship of cocoa intake to central and peripheral blood pressure, arterial stiffness, and carotid intima-media thickness in subjects with some cardiovascular risk factor. Findings Design: A cross-sectional study of 351 subjects (mean age 54.76 years, 62.4% males. Measurements: Intake of cocoa and other foods using a food frequency questionnaire, central and peripheral (ambulatory and office blood pressure, central and peripheral augmentation index, pulse wave velocity, ambulatory arterial stiffness index, carotid intima-media thickness, and ankle-brachial index. Results: Higher pulse wave velocity and greater cardiovascular risk were found in non-cocoa consumers as compared to high consumers (p Conclusions In subjects with some cardiovascular risk factors, cocoa consumption does not imply improvement in the arterial stiffness values. Trial Registration Clinical Trials.gov Identifier: NCT01325064.

  1. Working at Night in Hospital Environment is a Risk Factor for Arterial Stiffness

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    Sinem Özbay

    2012-09-01

    Full Text Available Aim: Arterial stiffness is an independent risk factor for cardiovascular disease. In previous studies, emotional stress has been reported to be a risk factor for cardiovascular disease. In this study, we aimed to investigate the effects of anxiety, stress and fatigue associated with working at night in hospital environment on arterial stiffness in physicians. Methods: The study was carried out with 30 physicians employed in Medical Faculty of Uludağ University between October 2011 and March 2012. Measurements were made using Pulse Wave Sensor HDI system (Hypertension Diagnostics Inc, Eagan, MN(Set No: CR000344 by radial artery pulse wave at the onset and end of night shift. Results: The mean age of night doctors included in the study was 26 years (range: 22-38 and the female/male ratio was 2/1. It was determined that mean values of arterial stiffness were significantly higher after night shift (1330±360 dyne/sn/cm-5 compared to mean values before night shift (1093±250 dyn/s/cm-5 (p=0.01. In the evaluation of other parameters before and after night shift, no statistically significant difference was detected (p>0.05. Conclusion: The increasing arterial stiffness in hospital employees after night shift could be attributed to the effects of stress and fatigue experienced during night shift. (The Me di cal Bul le tin of Ha se ki 2012; 50: 93-5

  2. La obesidad como factor de riesgo en el desarrollo de cáncer

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    Deissy Herrera-Covarrubias

    2015-10-01

    Full Text Available De acuerdo con la Organización Mundial de la Salud, cada año fallecen 3,4 millones de personas adultas por consecuencias del sobrepeso u obesidad. Personas con un índice de masa corporal superior a 30, presentan cierto aumento en la incidencia de algunas enfermedades entre las que se encuentran algunos tipos de cánceres. En esta revisión de tipo narrativa se aborda el papel que tiene el tejido adiposo como modulador del sistema endocrino y facilitador de la inflamación crónica subclínica. Se discute cómo la obesidad puede producir un microambiente favorable para el desarrollo de tumores, principalmente por el incremento del estrés oxidativo y en las concentraciones de diversas hormonas como la leptina, la insulina y la prolactina. Se concluye que, en conjunto, estos factores incrementan la probabilidad de desarrollar cáncer

  3. La obesidad como factor de riesgo en el desarrollo de cáncer

    Directory of Open Access Journals (Sweden)

    Deissy Herrera-Covarrubias

    2015-12-01

    Full Text Available De acuerdo con la Organización Mundial de la Salud, cada año fallecen 3,4 millones de personas adultas por consecuencias del sobrepeso u obesidad. Personas con un índice de masa corporal superior a 30, presentan cierto aumento en la incidencia de algunas enfermedades entre las que se encuentran algunos tipos de cánceres. En esta revisión de tipo narrativa se aborda el papel que tiene el tejido adiposo como modulador del sistema endocrino y facilitador de la inflamación crónica subclínica. Se discute cómo la obesidad puede producir un microambiente favorable para el desarrollo de tumores, principalmente por el incremento del estrés oxidativo y en las concentraciones de diversas hormonas como la leptina, la insulina y la prolactina. Se concluye que, en conjunto, estos factores incrementan la probabilidad de desarrollar cáncer

  4. Risk Factors and Clinical Evaluation of Superficial Femoral Artery Stent Fracture: Prote'ge'GPS Stent

    International Nuclear Information System (INIS)

    To evaluate the occurrence of superficial femoral artery stent fractures, the risk factors of stent fracture, and the relationship between fractures and clinical findings. Of the 38 patients who underwent treatment with Prote'ge'GPS stenting due to arterial occlusions on the superficial femoral artery, 17 also underwent a clinical analysis. Forty-three stents were inserted in the 17 superficial femoral arteries, ranging between 15 and 50 cm in length, with a mean treated length of 26.4 cm (15-50 cm). A fracture was evaluated by taking a PA and lateral simple radiography, as well as a follow-up evaluation accompanied with a CT angiography, DSA, and a color Doppler sonography. The examination involved the assessment of the difference between bone fractures due to length, placement, and frequency. Fractures occurred in 13 of 43 stents (30.2%). A total of 10 (71.4%) occurred in the upper third, compared to 4 (28.6%) in the lower third of the superficial femoral artery. In addition, 10 stents (71.4%) had a single strut fracture, whereas 4 (28.6%) had multiple strut fractures. A stent fracture occurred more frequently when the stents and lesions were longer (p=0.021, 0.012) and the stents were inserted near the joint. However, there was no significant relationship between stent numbers and the fractures (p=0.126). When the stents were inserted along the popliteal artery, a stent fracture occurred more frequently in the lower third of the artery. The stent fractures did not significantly influence the patency rate of the stented artery (p=0.44) Prote'ge'GPS stents in the superficial femoral artery revealed a considerable number of fractures and the fracture frequency showed a significant relationship with the length of stents and lesions. The closer stent insertion was to the joints, the more frequently fractures occurred. There were no evident significant relationships between the presence of stent fractures and the patency of the stented arteries

  5. Acute interventional diagnosis and treatment of upper gastrointestinal arterial hemorrhage: its clinical value and influence factors

    International Nuclear Information System (INIS)

    Objective: To evaluate emergent angiography and interventional management in treating massive upper gastrointestinal (GI) arterial hemorrhage, and to discuss the factors influencing the angiographic bleeding signs and the interventional therapeutic results. Methods: The clinical data of 56 patients with massive upper GI arterial hemorrhage, who underwent diagnostic arteriography and interventional management with trans-catheter vasopressin infusion and embolization, were retrospectively analyzed. Systolic blood pressure of both pre-and post-interventional therapy was recorded and statistically analyzed. The arteriographic positive rates were separately calculated according to the catheter tip's location, being placed at the 2nd grade branch or at the 3 rd -4 th grade branch of the artery, and the relation of the positive rate with the tip's location was analyzed. A comparison of the hemostatic effect between trans-catheter vasopressin infusion and trans-catheter embolization was made. Results: The average systolic blood pressure of pre-and post-procedure was (93.14 ± 18.63) mmHg and (11.64 ± 13.61) mmHg respectively, with a significant difference (P = 0.023). The angiographic bleeding signs were demonstrated in 12 cases (21.4%) with the catheter's tip at the 2nd grade branch and in 56 cases (100%) with the catheter's tip at the 3 rd -4 th grade branch,the difference between the two was of statistically significance (P < 0.05). The technical success rate and the clinical hemostasis rate of via catheter vasopressin infusion was 80% (16 / 20) and 55% (11/20) respectively. Of nine re-bleeding cases, seven were successfully controlled with embolization therapy by using microcatheter and two had to receive surgery because of arterial rupture which was proved by angiography. The technical and the clinical rates of success for transcatheter embolization therapy were 93% (42 / 45) and 89% (40 / 45) respectively. Recurrence of bleeding was seen in two patients who got

  6. Pattern of coronary artery disease with no risk factors under age 35 years

    International Nuclear Information System (INIS)

    Coronary artery disease (CAD) is no more deemed to be an ailment of the 4 or 5 decade; rather an earlier age incidence is not infrequently encountered in our population. However, there are a few data regarding CAD in young adults, and much about its underlying pathology still remains undetermined. The objective of this study was to delineate the coronary arterial disease pattern in adults under the age of 35 years, but having no known coronary risk factors. Methods: This prospective study was conducted at the Cardiology Departments of all 3 public sector tertiary care hospitals in Peshawar from Jun 2008 to Dec 2009. After having excluded the traditional risk factors for CAD, patients under the age of 35 years with objective evidence of CAD were subjected to percutaneous coronary angiography. Results: Out of a total of 104 patients, 85 (81.73%) patients were men, and 19 (18.27%) were women. The mean age of the whole group was 32.66 +- 3.237 (22-35) years. Significant CAD (>50% diameter narrowing of at least one major coronary artery) was found in 87 (83.7%) patients while 17 (16.3%) patients had non-atherosclerotic coronary artery disease, including 12 (11.53%) patients having normal coronary arteries, 1 (1%) patient had anomalous origin of right coronary artery (RCA), 1 (1%) patient had coronary arteritis, 2 (1.92%) patients had coronary artery ectasia, and 1 (1%) patient had a myocardial bridge over left anterior descending artery (LAD). Among the patients with significant CAD, the prevalence rate of one, two and three vessel disease was 54 (51.9%), 22 (21.2%) and 11 (10.6%) respectively. Almost 50% of the lesions occurred in LAD followed by 25% in RCA and 20% in circumflex, while only one patient (1%) had isolated significant CAD of left main coronary artery. Osteal segments were involved in 10%, proximal in 61%, mid in 21% and distal segments in 7% of the lesions. Conclusion: In the younger age group, CAD is mostly a disease of men, single vessel CAD

  7. Risk factors for deterioration of renal function after coronary artery bypass grafting

    OpenAIRE

    van Straten, Albert; Hamad, Mohamed; Van Zundert, Adrien; Martens, Elisabeth; Schönberger, Jacques; de Wolf, Andre

    2010-01-01

    Abstract Objective: Various definitions of impairment of renal function after coronary artery bypass grafting (CABG) are used in the literature. Depending on the definition, several risk factors are identified. We analysed our data to determine the risk factors for postoperative deterioration of the creatinine clearance of 10% or more. Methods: All patients undergoing isolated coronary surgery in a single centre between January 1998 and December 2007 are included. Clinical data, including ...

  8. Prognostic factors in the treatment of locally advanced hepatocellular carcinoma with radiotherapy and arterial infusion

    International Nuclear Information System (INIS)

    Prognostic factors in the treatment of local advanced hepatocellular carcinoma with radiotherapy, transcatheter arterial embolization and arterial infusion. The treatment effects of radiotherapy and combination modality therapy for the local advanced hepatocellular carcinoma (HCC) were retrospectively reviewed. Three hundred and fifty-six patients of HCC (187 recurrent cases after surgical resection) were treated by: radiotherapy only ; bi-therapeutic method: hepatic artery ligation (HAL) and/or hepatic artery embolization (HAE) plus radiotherapy; and tri-therapeutic method (bi-therapeutic method plus hepatic artery infusion) from 1975 to 1996. Kaplan-Meier method has been used to evaluate the survival rates. There were no significant differences among these three treatment groups in the symptom relied rate, but the mean relief time period was much shorter in radiotherapy alone group (2.5 vs 44 months, P 0.05). There were evident differences in five-year survivals among these three treatment groups: 0 % for radiotherapy alone, 22.8 % for bi-therapeutic method and 38.8 % for tri-therapeutic method (P < 0.01). The prognosis was influenced by Okuda classification. Non-resectable local advanced HCC can be treated by the combination modality therapy, including radiotherapy, with a quite high cure rate. Radiotherapy alone can relief the symptoms. (authors)

  9. Renal dysfunction and state of metabolic and hemodynamic factors in patients with arterial hypertension

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    Klochkov V.A.

    2011-12-01

    Full Text Available The aim of the investigation is to carry out comparative evaluation of metabolic and hemodynamic indices in patients with arterial hypertension (AH and renal dysfunction; to study the interrelation between arterial blood pressure level normalization and the presence or lack of microalbuminuria (MAU in the morning urine portion of patients with AH after therapy with antihypertensive preparations (APs of various groups. Methods. 121 persons have been investigated, 91 out — patients of both sexes, aged 33-55, with the diagnosis of arterial hypertension of stage II risk III, who have been taking Perindopril, Telmisartan and Bisoprolol for3 months. The control of arterial pressure level, biochemical analysis of metabolic indices and morning urine portion test for microalbuminuria has been carried out. Results. MAU has been revealed in 17,6% patients, occurring more frequently in men than in women. Microalbuminuria is accompanied by reliable decrease of total and ionized calcium and magnesium concentrations, an increase of potassium level in blood plasma, increase of cholesterol, triglycerides, glucose and levels. Patients with AH and renal dysfunction reliably demonstrate higher levels of systolic and diastolic arterial pressure in the morning and evening hours, their normalization effect after APs intake is significantly interconnected with MAU presence. Conclusion. In patients with AH and MAU the main risk factors of cardio-vascular diseases development are more expressed. Microalbuminuria is a risk factor in patients with arterial hypertension and may influence on the basic blood electrolyte balance. While carrying out antihypertensive therapy the presence of MAU should be taken into consideration

  10. A influência de fatores emocionais sobre a hipertensão arterial The influence of emotional factors on the arterial hypertension

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    Fabiana de Cássia Almeida Fonseca

    2009-01-01

    Full Text Available OBJETIVO: Realizar revisão bibliográfica de artigos que abordam a relação entre hipertensão arterial e fatores emocionais, levando em consideração a relevância do tema. MÉTODOS: Fez-se busca ativa na Biblioteca Virtual em Saúde, na base de dados MedLine (1997-2008, utilizando palavras da língua portuguesa. Os descritores de assunto escolhidos foram "hipertensão" e "doença cardíaca coronária". Em seguida, refinou-se a busca com os termos "hostilidade", "raiva", "ansiedade", "comportamento impulsivo" e "personalidade impulsiva". Não foram selecionados artigos que tratavam exclusivamente de doenças cardiovasculares e fatores psicológicos ou que associavam hipertensão e doenças cardiovasculares com depressão e doença de Alzheimer. RESULTADOS E DISCUSSÃO: Há inconsistência nos achados que relacionam os fatores emocionais com a hipertensão arterial e cardiopatias. Foram encontrados tanto estudos que demonstram relação positiva da raiva, hostilidade, ansiedade, impulsividade e estresse com hipertensão e doenças cardiovasculares quanto estudos que retratam relações negativas. CONCLUSÃO: O que se pode inferir das relações pesquisadas é que o risco de desenvolvimento da hipertensão arterial e a reatividade cardiovascular parecem ser influenciados por fatores emocionais como impulsividade, hostilidade, estressores, ansiedade e raiva. No entanto, mais estudos são necessários para melhor elucidar essas relações.OBJETIVE: Conduct a bibliographic review of articles that deal a relationship between hypertension and emotional factors considering relevance of the subject. METHODS: Through an active search in the Virtual Health Library, querying the database MedLine (1997-2008, we used words of the Portuguese language. The chosen descriptors are "hypertension" and "coronary heart disease". After that, the search was improved by the adding of terms "hostility", "anger", "anxiety", "impulsive behavior" and "impulsive

  11. Postoperative internal carotid artery restenosis after local anesthesia: presence of risk factors versus intraoperative shunt.

    Science.gov (United States)

    Hudorovic, Narcis; Lovricevic, Ivo; Hajnic, Hrvoje; Ahel, Zaky

    2010-08-01

    Published data suggest that the regional anesthetic technique used for carotid endarterectomy (CEA) increases the systolic arterial blood pressure and heart rate. At the same time local anesthesia reduced the shunt insertion rate. This study aimed to analyze risk factors and ischemic symptomatology in patients with postoperative internal carotid artery restenosis. The current retrospective study was undertaken to assess the results of CEA in 8000 patients who were operated during a five-year period in six regional cardiovascular centers. Carotid color coded flow imaging, medical history, clinical findings and atherosclerotic risk factors were analyzed. Among them, there were 33 patients (0.4%) with postoperative re-occlusion after CEA. The patients with restenosis were re-examined with carotid color coded flow imaging and data were compared with 33 consecutive patients with satisfactory postoperative findings to serve as a control group. In the restenosis group eight risk factors were analyzed (hypertension, smoking, hyperlipidemia, diabetes mellitus, history of stroke, transitory ischemic attack, heart attack and coronary disease), and compared with risk factors in control group. Study results suggested that early postoperative internal carotid artery restenosis was not caused by atherosclerosis risk factors but by intraoperative shunt usage. PMID:20439301

  12. Hyperhomocystenemia is a Risk Factor For Coronary Artery Disease in Patients of Diabetes Mellitus in India

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    Dr. Ashok Kumar Behera

    2014-12-01

    Full Text Available Background: Prevalence of coronary artery disease (CAD is very high amongst the people of Indian subcontinent. Among the Indians more than 60% of the CAD remains unexplained by conventionally risk factor. Recently a number of new cardiovascular risk factors have been identified & homocysteine is one of them. Various clinical studies have shown that higher homocysteine level is a risk factor for atherosclerotic vascular disease. Studies on the association of hyperhomocysteinemia as a cardiovascular risk factor in Indian patients have shown conflicting results. Hyperhomocysteinemia has been reported both in type-1 and type-2 Diabetes mellitus & has been correlated with macro vascular complication in western population. There is very limited number of studies of hyperhomocysteinemia as a cardiovascular risk factor in Indian Diabetic patients. So we undertook this study. Methods: We studied 80 patients of diabetes mellitus with 20 healthy control subjects. Out of 80 patients, 40 patients of diabetes mellitus with CAD (Group-Cand their homocysteine level compared with 40 patients of diabetes mellitus without CAD (Group-B and 20 controls (Group-A. Results: The mean homocysteine level in Group-A is found to be 10.2±1.4 μmol/L, in Group-B is 12.75±4.2 μmol/L where as in Group-C is 19.4±7.5 μmol/L. The mean homocysteine level was significantly high in patients of diabetes mellitus with coronary artery disease in comparison to patients of diabetes mellitus without coronary artery disease and healthy controls at p<0.01. Conclusion: Increased level of homocysteine is a risk factor for coronary artery disease in patients with of diabetes mellitus.

  13. El entorno familiar y social de la madre como factor que promueve o dificulta la lactancia materna

    OpenAIRE

    Fabiola Becerra-Bulla; Libertad Rocha-Calderón; Dayana Milena Fonseca-Silva; Laura Andrea Bermúdez-Gordillo

    2015-01-01

    Antecedentes. Existe suficiente evidencia científica sobre las bondades de la práctica de la lactancia materna para el binomio madre-hijo. Se plantean diversas políticas y programas encaminados a promover, proteger y apoyar la lactancia materna, muchas veces, haciendo caso omiso de múltiples factores que la permean, como factores sociales, culturales, familiares y personales que pueden hacer que sea una experiencia exitosa o no. Objetivo. Identificar los factores determinantes de tipo social,...

  14. [The role of the team of family physician in prevention of changing risk factors important in development of arterial hypertension].

    Science.gov (United States)

    Beganlić, Azijada; Batić-Mujanović, Olivera; Tulumović, Ajsa; Zilzić, Muharem

    2005-01-01

    Arterial hypertension (AH) is one of the commonest noninfective chronic disease according to its important and the role in the morbidity and mortality, which is the reason for patients coming to the family phisician. Detection and treatment of high blood pressure are the major responsibility of physician in the primary care. If the family physician team (physician and nurse) make a good assessment of the risk factors which is important in development of arterial hypertension, the appearance of disease and its complications can be prevented or delayed. The most important for prevention of arterial hypertension is adoption a healthy lifestyle and it is nonseparate part of arterial hypertension treatment. PMID:16268072

  15. Las variables emocionales como factores de riesgo de los trastornos de la conducta alimentaria

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    Aitziber Pascual

    2011-01-01

    Full Text Available Este estudio ex post facto analizó si determinadas variables emocionales pueden considerarse factores de riesgo de los trastornos de la conducta alimentaria (TCA. Se analizaron las siguientes variables: ansiedad-rasgo, dificultad para identificar y expresar las emociones (alexitimia, autoestima, actitud negativa hacia la expresión emocional, percepción negativa de las emociones, influuencia de la alimentación, el peso y la figura corporal en el estado de ánimo, necesidad de control y estrategias de afrontamiento. Participaron 368 mujeres: 78 con TCA, 145 en riesgo de TCA y 145 de un grupo de control normativo. La variable que mostró mayor capacidad discriminante de todos los tipos de riesgo frente al grupo de control fue la relativa a la influencia en el estado de ánimo. Asimismo, la baja autoestima mostró buena capacidad para discriminar el riesgo de purga/atracón, y el riesgo de anorexia y purga/atracón frente al grupo control; a su vez, las formas de afrontamiento acción impulsiva y expresión emocional mostraron buena capacidad para discriminar el riesgo de anorexia del grupo control. Estos resultados tienen implicaciones importantes tanto en el área de la evaluación como en el de la prevención de estos trastornos.

  16. Prevalence of carotid artery calcification in postmenopausal women and its correlation with atherogenic risk factors

    OpenAIRE

    Patil, Santosh R.

    2015-01-01

    Aim: The aim of the present study was to determine the prevalence of carotid artery calcification (CAC) in postmenopausal females on panoramic radiographs and to study the correlation of CAC with possible risk factors such as hypertension, osteoporosis, and hypercholesterolemia, among others. Materials and Methods: Totally, 1214 panoramic radiographs of postmenopausal females attending the Department of Oral Medicine and Radiology were examined for the presence of CAC. The subjects were also ...

  17. Surgical infrainguinal revascularization for peripheral arterial disease: factors affecting patency rate

    OpenAIRE

    Jafarian, Ali; Elyasinia, Fezzeh; Keramati, Mohammad Reza; Ahmadi, Farham; Parsaei, Reza

    2015-01-01

    Background: Peripheral arterial disease is a source of morbidity and mortality. Surgical vascular reconstruction is a treatment option but probability of failure and complications are important concerns. In this study, we evaluated outcome of surgical infrainguinal reconstruction and factors affecting graft patency for a period of one year. Methods: In this cohort study, 85 consecutive patients with chronic ischemia who underwent lower extremity surgical vascular reconstruction (including 52 ...

  18. Association of Aortic Valve Sclerosis with Previous Coronary Artery Disease and Risk Factors

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    Filipe Carvalho Marmelo

    2014-11-01

    Full Text Available Background: Aortic valve sclerosis (AVS is characterized by increased thickness, calcification and stiffness of the aortic leaflets without fusion of the commissures. Several studies show an association between AVS and presence of coronary artery disease. Objective: The aim of this study is to investigate the association between presence of AVS with occurrence of previous coronary artery disease and classical risk factors. Methods: The sample was composed of 2,493 individuals who underwent transthoracic echocardiography between August 2011 and December 2012. The mean age of the cohort was 67.5 ± 15.9 years, and 50.7% were female. Results: The most frequent clinical indication for Doppler echocardiography was the presence of stroke (28.8%, and the most common risk factor was hypertension (60.8%. The most prevalent pathological findings on Doppler echocardiography were mitral valve sclerosis (37.1% and AVS (36.7%. There was a statistically significant association between AVS with hypertension (p < 0.001, myocardial infarction (p = 0.007, diabetes (p = 0.006 and compromised left ventricular systolic function (p < 0.001. Conclusion: Patients with AVS have higher prevalences of hypertension, stroke, hypercholesterolemia, myocardial infarction, diabetes and compromised left ventricular systolic function when compared with patients without AVS. We conclude that there is an association between presence of AVS with previous coronary artery disease and classical risk factors.

  19. Risk factors for peripheral arterial disease in the tropics and its comparison with the western population

    Institute of Scientific and Technical Information of China (English)

    Myla Yacob; Edwin Stephen; Nupur Bit; Mazda Turel; David Sadhu; Sunil Agarwal

    2010-01-01

    Objective:To identify and compare the existence of similar and other risk factors in the perspective of an Indian population. Methods:It was designed as a case control study and was conducted in the Department of General and Vascular Surgery Unit 2 of Christian Medical College, Vellore, India between the periods July 2003 to June 2005. 100 patients with an ABPI<0.9 and 100 controls were studied. Results:Peripheral arterial disease (PAD) was found to be commoner among males (87%). While atherosclerosis was the commonest aetiology (54%), the incidence of Thromboangiitis Obliterans was also not uncommon (38%). Smoking was the main risk factor in the Indian context (83%) as compared to hypercholesterolemia (60%) in the West. The patients with atherosclerotic PAD were middle-aged and had concomitant diabetes (50%) and hypertension (30%). Conclusions:Peripheral arterial disease occurs in a relatively younger age group in India as compared to their Western counterparts. Thromboangiitis Obliterans was found to be a significant aetiology for arterial occlusive disease, with smoking as the primary risk factor followed by diabetes, hypertension and hypercholesterolemia.

  20. El perfil de los entrenadores de balonmano. La formación como factor de cambio.

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    Sergio José Ibáñez Godoy

    2009-12-01

    Full Text Available Normal 0 21 false false false ES X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Tabla normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin-top:0cm; mso-para-margin-right:0cm; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0cm; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} Feu, S. (2006 El perfil de los entrenadores de balonmano. La formación como factor de cambio. Cáceres. Ilustre Colegio de Licenciados en Educación Física y Ciencias de la actividad Física y el Deporte de Extremadura. 250 pp.  ISSN:  84-689-7612-1   Resumen El Ilustre Colegio de Licenciados en Educación Física y Ciencias de la Actividad Física y el Deporte de Extremadura edita los resultados, aplicaciones y prospectiva de una investigación subvencionada por el Consejo Superior de Deportes. La publicación ha sido subvencionada a través  de una ayuda concedida por la Consejería de Cultura de la Junta de Extremadura al autor, Sebastián Feu Molina. El manuscrito se estructura en nueve capítulos que van desbrozando paso a paso, en los capítulos del uno al octavo, las fases de una investigación que surge con el objetivo de identificar los perfiles de entrenador y las variables que afectan a los entrenadores en la adopción de los mismos. En el capítulo nueve el autor expone las aplicaciones que surgen de la investigación, poniendo el acento en la formación como principal medio para orientar la adopción de los perfiles más adecuados en un entrenador. Palabras clave: Balonmano, Entrenador, Perfil, Variables

  1. Traditional cardiovascular risk factors and coronary artery calcification in adults with polymyositis and dermatomyositis

    DEFF Research Database (Denmark)

    Diederichsen, Louise C. Pyndt Raun; Diederichsen, Axel C P; Simonsen, Jane A;

    2015-01-01

    OBJECTIVE: To determine the occurrence of traditional cardiovascular (CV) risk factors and coronary artery calcification (CAC) in adults with polymyositis (PM) or dermatomyositis (DM) compared to healthy controls and to assess the association between CV risk factors, PM/DM, and CAC score. METHODS......: Traditional CV risk factors were assessed in a cross-sectional, observational study of 76 patients with PM/DM and in 48 sex- and age-matched healthy controls. CAC was quantified by means of cardiac computed tomography scan and expressed in Agatston units. The associations between CV risk factors, PM/DM, and...... of triglycerides (P = 0.0009). High CAC score occurred more frequently in patients (20% versus 4%; P = 0.04). In multivariate analysis of patient factors associated with CAC were age (P = 0.02) and smoking (P = 0.02). CONCLUSION: In this study, traditional CV risk factors and severe CAC were commonly...

  2. Fatores de risco para doença arterial coronariana em idosos: análise por enfermeiros utilizando ferramenta computacional Factores de riesgo para enfermedad arterial coronaria en ancianos: análisis por enfermeras utilizando herramienta computacional Risk factors for coronary artery disease in the elderly: analysis by nurses using computational tool

    Directory of Open Access Journals (Sweden)

    Silvia Sidnéia da Silva

    2010-12-01

    Full Text Available Este trabalho objetivou analisar a ocorrência dos fatores de risco para doença arterial coronariana em população idosa participante de uma ação comunitária utilizando ferramenta computacional por enfermeiros. Para o desenvolvimento do trabalho utilizou-se uma base de dados coletada em um evento comunitário. As informações se referem a fatores de risco, dados antropométricos, aferição de valores de glicemia, colesterol e pressão arterial, ocorrência de doença cardíaca e outras. A estrutura multidimensional foi elaborada e gerenciada pela ferramenta Analysis Services. A população idosa correspondeu a 40,4% do total, um terço dessa população estava com valores alterados de pressão arterial sistêmica, 53,8% apresentavam índice de massa corporal acima de 25 Kg/m², 40,3% referiram hipertensão e 20,3%, diabetes mellitus. Conclui-se que o controle de fatores de risco para DAC em clientes idosos é essencial e que a tecnologia da informação pode apoiar na tomada de decisões estratégicas de promoção de saúde.Este trabajo tuvo como objetivo analizar la ocurrencia de los factores de riesgo para enfermedad arterial coronaria en la población anciana participante de una acción comunitaria con una herramienta computacional para las enfermeras. Para el desarrollo del trabajo se utilizó una base de datos colectada en un evento comunitario. Las informaciones se refieren a factores de riesgo, datos antropométricos, contraste de valores de glucemia, colesterol y presión arterial, ocurrencia de enfermedad cardiaca y otras. La estructura multidimensional fue elaborada y administrada por la herramienta Analysis Services. La población anciana correspondió a 40,4% del total, un tercio de esta población estaba con valores alterados de presión arterial sistémica, 53,8% presentaban índice de masa corporal arriba de 25Kg/m², 40,4% se referían a hipertensión y 20,3% diabetes mellitus. Se concluye que el control de factores de

  3. Novel risk factors for premature peripheral arterial occlusive disease in non-diabetic patients: a case-control study.

    Directory of Open Access Journals (Sweden)

    Annie M Bérard

    Full Text Available BACKGROUND: This study aimed to determine the prevalence of genetic and environmental vascular risk factors in non diabetic patients with premature peripheral arterial disease, either peripheral arterial occlusive disease or thromboangiitis obliterans, the two main entities of peripheral arterial disease, and to established whether some of them are specifically associated with one or another of the premature peripheral arterial disease subgroups. METHODS AND RESULTS: This study included 113 non diabetic patients with premature peripheral arterial disease (diagnosis <45-year old presenting either a peripheral arterial occlusive disease (N = 64 or a thromboangiitis obliterans (N = 49, and 241 controls matched for age and gender. Both patient groups demonstrated common traits including cigarette smoking, low physical activity, decreased levels of HDL-cholesterol, apolipoprotein A-I, pyridoxal 5'-phosphate (active form of B6 vitamin and zinc. Premature peripheral arterial occlusive disease was characterized by the presence of a family history of peripheral arterial and carotid artery diseases (OR 2.3 and 5.8 respectively, 95% CI, high lipoprotein (a levels above 300 mg/L (OR 2.3, 95% CI, the presence of the factor V Leiden (OR 5.1, 95% CI and the glycoprotein Ia(807T,837T,873A allele (OR 2.3, 95% CI. In thromboangiitis obliterans group, more patients were regular consumers of cannabis (OR 3.5, 95% CI and higher levels in plasma copper has been shown (OR 6.5, 95% CI. CONCLUSIONS: According to our results from a non exhaustive list of study parameters, we might hypothesize for 1 a genetic basis for premature peripheral arterial occlusive disease development and 2 the prevalence of environmental factors in the development of thromboangiitis obliterans (tobacco and cannabis. Moreover, for the first time, we demonstrated that the 807T/837T/873A allele of platelet glycoprotein Ia may confer an additional risk for development of peripheral

  4. A case - control study of risk factors for coronary artery disease in Pakistani females

    International Nuclear Information System (INIS)

    Objectives: To establish the strength of association of conventional risk factors for coronary artery disease in native Pakistani females. Methods: We conducted a case - control hospital based study on 198 females (age 30 - 80 years) scheduled for their first coronary angiography at Punjab Institute of Cardiology, Lahore. Patients were divided into pre-menopausal group (age: 45.1 +- 6.3) and post-menopausal group (62.1 +- 9.1). For each risk factor, patients with significant CAD (= 50% luminal diameter stenosis) were regarded as cases an those without significant CAD were taken as controls. Odds Ratios (OR) and their 95% confidence intervals (CI) were calculated by univariate analysis. Results: In total study cohort, Diabetes mellitus (OR 3.65 95% CI 2.0 - 6.5), Family history of premature coronary artery disease (OR 2.3, 95% CI 1.2 - 4.4), and increased waist circumference (OR 2.11, 95% CI 1.2 - 3.8) were strongly associated with significant CAD. In post menopausal age group, diabetes mellitus (OR 2.66 CI 1.3 - 5.1), hyperlipidaemia (OR 2.25 CI 1.2 - 2.3) and increased waist circumference (OR 2.16 CI 1.1 - 4.2) reached statistical significance. In pre-menopausal females only diabetes was strongly associated with significant coronary artery disease (OR 10 CI 2.6 - 37.4). Association of hypertension was not significant in any of subgroups studied. Very few cases of smoking (6 / 198) were found in our study to merit any further statistical analysis. Conclusions: Diabetes mellitus was the only risk factor in pre-menopausal females associated with coronary artery disease While diabetes, hyperlipidaemia and increased waist circumference were significantly associated with CAD in post menopausal females. (author)

  5. La resiliencia del docente como factor crucial para superar las adversidades en una sociedad de cambios

    OpenAIRE

    Aguaded Gómez, Mª Cinta; Almeida Pires Cavaco, Nora Alejandra

    2016-01-01

    La resiliencia y el desarrollo humano son conceptos de suma importancia que requieren una reflexión y un análisis detallado y necesario para el sujeto, tanto a nivel personal como profesional. La resiliencia es concebida por tanto como un fenómeno, un funcionamiento, un proceso, o, a veces, como una característica que refleja una capacidad. Este fenómeno no es constante o permanente, pudiendo el sujeto, o en este caso particular, el educador, ser resiliente en ciertas áreas ...

  6. El audiovisual español como factor coadyuvante de la marca España

    OpenAIRE

    Tribaldos Macia, Enrique

    2013-01-01

    El objetivo de este trabajo es determinar el impacto que tiene el Sector Audiovisual Español entendido desde tres perspectivas distintas. Primero como alfabeto universal base del ecosistema mediático digital multimedia. Segundo, como contenido creativo de valor artístico. Y tercero como industria destacada, competitiva y próspera con un enorme potencial en el mercado internacional. Por lo tanto, trataremos de investigar sobre si el Sector Audiovisual reúne los requisitos suficientes en la...

  7. Transforming growth factor-β inhibition attenuates pulmonary arterial hypertension in rats

    OpenAIRE

    Megalou, Aikaterini J; Glava, Chryssoula; Oikonomidis, Dimitrios L.; Vilaeti, Agapi; Agelaki, Maria G; Baltogiannis, Giannis G.; Papalois, Apostolos; Vlahos, Antonios P.; Kolettis, Theofilos M

    2010-01-01

    The role of transforming growth factor-β in the pathogenesis of pulmonary arterial hypertension is unclear. We examined the effects of T9429, an antibody against transforming growth factor-β receptors, on hemodynamic, histological and functional parameters in the rat model of monocrotaline-induced pulmonary hypertension. One week after monocrotaline injection (60 mg/kg) in 28 Wistar rats, T9429 (0.1mg/kg daily) was administered intraperito-neally in 19 rats (268±10g) via an osmotic mini-pump ...

  8. Risk factors related to systemic arterial hypertension in victims of cerebral vascular accident

    OpenAIRE

    Joselany Áfio Caetano; Verineida Lima; Enedina Soares; Zélia Maria de Sousa Araújo Santos

    2006-01-01

    The Cerebrovascular accident (AVC)is the third cause of death in the world.Apart systemic arterial hypertension (HAS),many other preventable factors are related to its appearance and evolution.This study aimed at identifying the risk factors for AVC in interned hypertensive patients.It was a descriptive study held at a philanthropic hospital in Sobral-Ceará,with fourteen patients taken ill with AVC.Among those,85.7%(n=12)were above 65 years old and the same quantitative were retired;71,4%(n=1...

  9. Prognostic factors in malignant gliomas with special reference to intra-arterial chemotherapy

    International Nuclear Information System (INIS)

    Survival was analyzed in 173 patients with malignant gliomas to study the importance of possible pretreatment prognostic factors. Seventy-nine of these patients received preirradiation intra-arterial chemotherapy with BCNU combined with vincristine intravenously and procarbazine orally; the others received only postoperative whole-brain irradiation. To judge by univariate and multivariate analyses the most important pretreatment prognostic factors wer histology, corticosteroid dependency, pretreatment performance status and frontal lobe location of the tumors. Patients with anaplastic astrocytoma, not corticosteroid-dependent, with pretreatment performance status of 0-2 and with a frontal lobe location of the tumor seemed to benefit most from preirradiation chemotherapy. (orig.)

  10. Arterial Ageing

    OpenAIRE

    Lee, Seung-Jun; Park, Sung-Ha

    2013-01-01

    Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on hypertension, the renin-angiotensin-aldosterone system and vascular inflammation which are modifiabl...

  11. Transcatheter arterial embolization for control of hemoptysis in pulmonary tuberculosis: analysis of prognostic factors

    International Nuclear Information System (INIS)

    To evaluate the effectiveness of transcatheter arterial embolization(TAE) and the relationship between therapeutic effect and prognostic factors after this procedure. Fifty-five patients with hemoptysis caused by pulmonary tuberculosis (TB) underwent TAE. We reviewed medical records of the history and activity of pulmonary TB, and the extent of treatment, and assessed plain chest PA for the extent of lesions;we also evaluated the angiographic findings of embolized arteries, and embolic agents. The initial success rate, as shown by immediate response, and recurrence during follow-up, were then observed. Using the Chi-square test, differences in these findings were analysed. Immediate control of hemoptysis was achieved in 46 of 55 patients(84%);24 of 46(52.2%), experienced recurrence. Initial failure and partial response rates were higher in patients with active pulmonary TB(p<0.05) than in those in whom the condition was inactive. The recurrence rate was higher among those who had pulmonary TB for between one and ten years (p<0.05). There was, however, no significant correlation between therapeutic effect and the extent of anti-TB treatment, the extent of lesions seen on plain chest PA, angiographic findings, embolized arteries, and embolic agents. The initial success rate of TAE was 84% and the recurrence rate was as high as 52.2%. Both activity and duration of pulmonary TB were prognostic factors in immediate response and recurrence.=20

  12. Estabilidad emocional y cortisol como factores diferenciadores de la fibromialgia Emotional stability and cortisol as differentiating factors for fibromyalgia

    Directory of Open Access Journals (Sweden)

    L.A. Díaz Robredo

    2011-03-01

    Full Text Available Este estudio busca un acercamiento al diagnóstico de la fibromialgia desde un modelo psicofisiológico del estrés. En la Introducción justificaremos los principios teóricos en que se basa este trabajo. Las hipótesis planteadas intentarán buscar la diferencia de factores psicológicos y de cortisol entre los grupos control y experimental, así como la correlación entre dichos factores. En el apartado Materiales y métodos nos centramos en los registros de cortisol y de variables de personalidad que realizamos en un grupo de 35 mujeres, 18 con fibromialgia y otras 17 libres de la enfermedad. Los aspectos psicológicos serán recogidos por el test de Personalidad CEP de Pinillos, mientras que el cortisol será medido mediante recolección de saliva. Los resultados, muestran diferencias significativas en los factores psicológicos y fisiológicos de los grupos. En las conclusiones afirmamos que el control emocional y los niveles de cortisol son factores distintivos de esta enfermedad con respecto a un grupo control. Sin embargo, no encontramos una correlación significativa entre control emocional y cortisol pudiendo ser debida a variables extrañas o al escaso número de sujetos de la muestra. Además, los resultados de cortisol suponen una contradicción a estudios previos en los que se observa una reducción de esta hormona en pacientes con fibromialgia, por lo que se recomienda una recogida de cortisol del ciclo diurno para complementar el estudio y solucionar estas disensiones.This study looks for an approach to the diagnosis of fibromyalgia from a psychophysiological model of stress. In the Introduction chapter, we will justify the theoretical principles in which this work is based on. The hypothesis that we suggest will try to find the difference in psychological factors and cortisol between control and experimental group, as well as the correlation of these two factors. In the instrument and method chapter, we will focus on the

  13. The Peripheral Arterial disease study (PERART/ARTPER: prevalence and risk factors in the general population

    Directory of Open Access Journals (Sweden)

    Vicheto Marisa

    2010-01-01

    Full Text Available Abstract Background The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index is a good marker of vascular events and may be diminished without presenting symptomatology (silent peripheral arterial disease. The aim of the study is to know the prevalence and associated risk factors of peripheral arterial disease in the general population. Methods We performed a cross-sectional, multicentre, population-based study in 3786 individuals >49 years, randomly selected in 28 primary care centres in Barcelona (Spain. Peripheral arterial disease was evaluated using the ankle-arm index. Values Results The prevalence (95% confidence interval of peripheral arterial disease was 7.6% (6.7-8.4, (males 10.2% (9.2-11.2, females 5.3% (4.6-6.0; p Multivariate analysis showed the following risk factors: male sex [odds ratio (OR 1.62; 95% confidence interval 1.01-2.59]; age OR 2.00 per 10 years (1.64-2.44; inability to perform physical activity [OR 1.77 (1.17-2.68 for mild limitation to OR 7.08 (2.61-19.16 for breathless performing any activity]; smoking [OR 2.19 (1.34-3.58 for former smokers and OR 3.83 (2.23-6.58 for current smokers]; hypertension OR 1.85 (1.29-2.65; diabetes OR 2.01 (1.42-2.83; previous cardiovascular disease OR 2.19 (1.52-3.15; hypercholesterolemia OR 1.55 (1.11-2.18; hypertriglyceridemia OR 1.55 (1.10-2.19. Body mass index ≥25 Kg/m2 OR 0.57 (0.38-0.87 and walking >7 hours/week OR 0.67 (0.49-0.94 were found as protector factors. Conclusions The prevalence of peripheral arterial disease is low, higher in males and increases with age in both sexes. In addition to previously described risk factors we found a protector effect in physical exercise and overweight.

  14. DIABETES MELLITUS COMO FACTOR DE RIESGO DE DEMENCIA EN LA POBLACIÓN ADULTA MAYOR MEXICANA

    Science.gov (United States)

    Silvia, Mejía-Arango; Clemente, y Zúñiga-Gil

    2012-01-01

    Introduccion La diabetes mellitus y las demencias constituyen dos problemas crecientes de salud entre la población adulta mayor del mundo y en particular de los paises en desarrollo. Hacen falta estudios longitudinales sobre el papel de la diabetes como factor de riesgo para demencia. Objetivo Determinar el riesgo de demencia en sujetos Mexicanos con diabetes mellitus tipo 2. Materiales y Metodos Los sujetos diabéticos libres de demencia pertenecientes al Estudio Nacional de Salud y Envejecimiento en México fueron evaluados a los dos años de la línea de base. Se estudió el papel de los factores sociodemográficos, de otras comorbilidades y del tipo de tratamiento en la conversión a demencia. Resultados Durante la línea de base 749 sujetos (13.8%) tuvieron diabetes. El riesgo de desarrollar demencia en estos individuos fue el doble (RR, 2.08 IC 95%, 1.59–2.73). Se encontró un riesgo mayor en individuos de 80 años y más (RR 2.44 IC 95%, 1.46–4.08), en los hombres (RR, 2.25 IC 95%, 1.46–3.49) y en sujetos con nivel educativo menor de 7 años. El estar bajo tratamiento con insulina incrementó el riesgo de demencia (RR, 2.83, IC 95%, 1.58–5.06). Las otras comorbilidades que aumentaron el riesgo de demencia en los pacientes diabéticos fueron la hipertensión (RR, 2.75, IC 95%, 1.86–4.06) y la depresión (RR, 3.78, 95% IC 2.37–6.04). Conclusión Los sujetos con diabetes mellitus tienen un riesgo mayor de desarrollar demencia, La baja escolaridad y otras comorbilidades altamente prevalentes en la población Mexicana contribuyen a la asociación diabetes-demencia. PMID:21948010

  15. Inflammation and infection do not promote arterial aging and cardiovascular disease risk factors among lean horticulturalists.

    Directory of Open Access Journals (Sweden)

    Michael Gurven

    Full Text Available Arterial aging is well characterized in industrial populations, but scantly described in populations with little access to modern medicine. Here we characterize health and aging among the Tsimane, Amazonian forager-horticulturalists with short life expectancy, high infectious loads and inflammation, but low adiposity and robust physical fitness. Inflammation has been implicated in all stages of arterial aging, atherogenesis and hypertension, and so we test whether greater inflammation associates with atherosclerosis and CVD risk. In contrast, moderate to vigorous daily activity, minimal obesity, and low fat intake predict minimal CVD risk among older Tsimane.Peripheral arterial disease (PAD, based on the Ankle-Brachial Index (ABI, and hypertension were measured in Tsimane adults, and compared with rates from industrialized populations. No cases of PAD were found among Tsimane and hypertension was comparatively low (prevalence: 3.5%, 40+; 23%, 70+. Markers of infection and inflammation were much higher among Tsimane than among U.S. adults, whereas HDL was substantially lower. Regression models examine associations of ABI and BP with biomarkers of energy balance and metabolism and of inflammation and infection. Among Tsimane, obesity, blood lipids, and disease history were not significantly associated with ABI. Unlike the Tsimane case, higher cholesterol, C-reactive protein, leukocytes, cigarette smoking and systolic pressure among North Americans are all significantly associated with lower ABI.Inflammation may not always be a risk factor for arterial degeneration and CVD, but instead may be offset by other factors: healthy metabolism, active lifestyle, favorable body mass, lean diet, low blood lipids and cardiorespiratory health. Other possibilities, including genetic susceptibility and the role of helminth infections, are discussed. The absence of PAD and CVD among Tsimane parallels anecdotal reports from other small-scale subsistence

  16. Adolescencia como factor de riesgo para complicaciones maternas y perinatales en Cali, Colombia, 2002-2007: Estudio de corte transversal

    OpenAIRE

    Lina María Congote-Arango; María Adelaida Vélez-García; Lisandro Restrepo-Orrego; Ángela Cubides-Munévar; Rodrigo Cifuentes-Borrero

    2012-01-01

    Objetivo: evaluar la adolescencia como factor de riesgo para complicaciones maternas y perinatales en Cali, Colombia, 2002-2007. Materiales y métodos: estudio de corte transversal, realizado en 29.158 mujeres gestantes de 34 años o menores atendidas en los años 2002-2007 en la red pública del municipio de Santiago de Cali en los tres niveles de atención. Incluyó la base de datos del tercer nivel y una muestra representativa del primer y segundo nivel. Se evaluaron como desenlaces maternos: lo...

  17. La articulación empleo-familia: análisis del apoyo social como factor regulador

    OpenAIRE

    Abdelaziz Rhnima; Juan Francisco Núñez Grapain

    2014-01-01

    La falta de compatibilidad entre los roles laborales y familiares es conocido como conflicto trabajo-familia. Se analiza el apoyo social como un factor atenuante del conflicto. Buscando elucidar cómo las múltiples formas y fuentes de apoyo social contribuyen a la articulación entre el empleo y la familia, se formularon dos modelos cuantitativos que se sometieron en forma de cuestionario autoadministrado a 536 participantes miembros de una asociación profesional de especialistas en relaciones ...

  18. Early teatment with hepatocyte growth factor improves pulmonary artery and right ventricular remodeling in rats with pulmonary artery hypertension by modulating cytokines expression

    Institute of Scientific and Technical Information of China (English)

    王晓林

    2014-01-01

    Objective To investigate the effect of early treatment with hepatocyte growth factor(HGF)on the cytokine expression and pulmonary artery,right ventricular(RV)remodeling in the rat model of pulmonary artery hypertension(PAH).Methods The rat model of PAH was produced by injecting monocrotaline,and the model rats were randomly divided into empty adenovirus transfection group(MCT group,n=10)and HGF gene transfection group(HGF group,n=10).Another group of rats served as the Sham operation group(Sham group n=10).After 4 weeks of HGF gene transfection,the histological sections of the lungs and right ventricular(RV)

  19. The superior mesenteric artery. The critical factor in the pouch pull-through procedure.

    Science.gov (United States)

    Smith, L; Friend, W G; Medwell, S J

    1984-11-01

    The critical factor in ileal pouch pull-through operations is the length of the superior mesenteric artery. The pouch must reach the dentate line and have adequate blood supply. A series of cadaver and morgue studies were performed to evaluate the two most popular pouches of the "J" and "S" configurations. The "S" pouch generally reaches 2 to 4 cm more caudad than the "J" pouch. If necessary, however, the "J" pouch can be lengthened 2 to 4 cm by cutting the branch vessel under tension to the pouch, sparing vessels to either side and the marginal arcade. The "S" pouch procedure always sacrifices the ileocecal artery, but the "J" pouch procedure does not necessarily do so. The greatest caudad reach is available when the ileum is cut flush with the cecum. To verify a rule of thumb for reaching the dentate line with the pouch, the length of the superior mesenteric artery (SMA) origin to the inferior margin of the symphysis pubis and the SMA to dentate line were compared. If the tip of the pouch or conduit reached 6 cm below the symphysis pubis, all pouches reached the dentate line. PMID:6499610

  20. Metallic stent implantation in patients with iliac artery occlusion: long-term patency rate and factors related to recurrence

    International Nuclear Information System (INIS)

    To determine the long-term patency rate in 68 patients with iliac artery occlusion who underwent metallic stent implantation, and to analyze the factors related to recurrence. Sixty-eight patients with occlusive disease of the iliac artery underwent implantation of a self-expandable metallic stent. The clinical symptoms were intermittent claudication (n=48), resting pain (n=11), and gangrene (n=9). Stent patency was determined by follow-up angiography and color Doppler imaging, and the cumulative patency rate using the Kaplan-Meier method. Cox's proportional hazard model was used to analyse recurrence-related factors involving clinical symptoms (Fontaine stage), risk factors, and anatomical factors such as lesion location, length, and the development of collaterals. The duration of follow-up varied from 1 day to 73 months (mean, 23.8 months). Arterial occlusion recurred in 16 of 68 patients (23.5%), and the cumulative patency rate was as follows: 95.4% at one month, 93.2% at six months, 80.1% at one year, 73.2% at two years, 68.9% at three years, and 62% at five years. According to a statistical analysis of risk factors, the recurrence (p=0.04) than in those without it, but in patients who smoked, hypertension, DM, and previous cerebrovascular disease were not statistically significant. With regard to anatomical factors, the recurrent rate for lesions involving the external iliac artery was 6.5 times higher (p=0.02) than for those involving the common iliac artery. Variations in the fontaine stage were not statistically significant indicators of recurrence. The recurrence rate after implantation of an iliac artery stent is higher in patients with heart disease than in those without it, and higher for occlusive lesions involving the external iliac artery than for those of the common iliac artery

  1. Inovação e competitividade como factores de oportunidade num contexto de crise

    OpenAIRE

    Santiago, Inês Conde

    2009-01-01

    Este trabalho tem como principais objectivos analisar os conceitos de inovação e competitividade, bem como explorar a sua influência no desempenho do sector vitivinícola português. Para a sua elaboração contribuíram investigações já feitas por autores reconhecidos, o conhecimento adquirido no estágio na José Maria da Fonseca nos EUA, o contacto com pessoas experientes no negócio do vinho e comércio internacional, com os consumidores e as observações pessoais do mercado. A experiência inter...

  2. Indicadores antropométricos como preditores de pressão arterial elevada em adolescentes Indicadores antropométricos como predictores de presión arterial elevada en adolescentes Anthropometric indicators as predictors of high blood pressure in adolescents

    Directory of Open Access Journals (Sweden)

    Carmem Cristina Beck

    2011-02-01

    Full Text Available FUNDAMENTO: A hipertensão arterial está relacionada ao incremento da gordura corporal, a qual pode ser avaliada por meio de indicadores antropométricos. OBJETIVO: Determinar o poder preditivo de indicadores antropométricos e estabelecer seus pontos de corte como discriminadores de pressão arterial elevada. MÉTODOS: Estudo transversal realizado com uma amostra de 660 adolescentes de 14 a 19 anos sendo 51,9% moças. Foram considerados os seguintes indicadores antropométricos: índice de massa corporal (IMC, circunferência da cintura, razão cintura/estatura e índice de conicidade. A pressão arterial elevada foi caracterizada por valores acima do percentil 90 para pressão arterial sistólica e/ou pressão arterial diastólica. Para identificação dos preditores de pressão arterial elevada, foi adotada a análise das curvas Receiver Operating Characteristic (ROC, com intervalo de confiança de 95%. Posteriormente, identificaram-se os pontos de corte com suas respectivas sensibilidades e especificidades. RESULTADOS: As áreas sob as curvas ROC com os intervalos de confiança foram: rapazes - circunferência de cintura = 0,80 (0,72-0,89; IMC = 0,79 (0,68-0,89; razão cintura/estatura = 0,77 (0,66-0,88; índice de conicidade = 0,69 (0,56-0,81 e para as moças - circunferência de cintura = 0,96 (0,92-1,00; IMC = 0,95 (0,87-1,00; razão cintura/estatura = 0,93 (0,85-1,00; índice de conicidade = 0,74 (0,50-0,98. Os diversos pontos de corte dos indicadores antropométricos com melhores poderes preditivos e suas respectivas sensibilidades e especificidades foram identificados. CONCLUSÃO: Apesar de a razão cintura/estatura e de o IMC terem apresentado boas áreas sob a curva ROC, sugere-se a utilização da circunferência de cintura para a predição da pressão arterial elevada.FUNDAMENTO: La hipertensión arterial está relacionada al incremento de la grasa corporal, a la que se puede evaluar por medio de indicadores antropom

  3. Rigidez arterial aumentada en la infección por VIH:factores asociados

    OpenAIRE

    Sánchez Parra, Clara

    2015-01-01

    En los pacientes infectados por el virus de la inmunodeficiencia humana (VIH) la importancia de la enfermedad cardiovascular (ECV) arteriosclerótica ha venido creciendo de forma progresiva desde la introducción y ulterior generalización del tratamiento antirretroviral de gran actividad (TARGA), objetivándose un a umento de la morbilidad y la mortalidad cardiovasculares en estos pacientes. Numerosos estudios relacionan este hecho con la presencia de diversos factores como son una mayor prevale...

  4. Comparison of Novel Coronary Artery Disease Risk Factors between Obese and Normal Adolescent

    Science.gov (United States)

    Kouzehgaran, Samaneh; Vakili, Rahim; Nematy, Mohsen; Safarian, Mohamad; Ghayour-Mobarhan, Majid; Khajedaluee, Mohamad

    2015-01-01

    Background Coronary artery disease is considered as the most common cause of death in all societies including Iran. This study seeks to compare the new risk factors of coronary-artery diseases in obese adolescents and control group. Methods In this cross-sectional study, amongst the obese adolescents registered in the nutrition clinic of Ghaem Hospital, 80 individuals were selected. As the control group, additional 80 adolescent students having the same gender and age as the obese group, but with normal weight were selected. These two groups were selected randomly and their serum level of vitamin D, anti-heat shock protein27 (HSP27), balance of oxidants and antioxidants, and homocysteine were determined and compared. Results In this study, 42 (53.2%) and 37 (46.8%) of the obese and normal weight groups were male, respectively. The mean value of triglyceride, cholesterol, and LDL in the obese group was higher than the normal group, but the mean value for HDL, vitamin D, homocysteine, PAB (Preoxidant and Antioxidants Balance), and anti-HSP27 was not significantly different between the groups. In the base of homocysteine >15 µmol/l, 26.6% of the obese group had hyperhomocysteinemia, therefore homocysteine may be a new risk factor for coronary artery disease in obese adolescents (χ2=4.072; P value=0.091). Conclusion The findings of this study showed that despite the presence of obesity in adolescence and adolescents, new risk factors are not present among them more than the control group. This was in contrast to what was seen in adults. PMID:26170518

  5. Risk Factors for Peripheral Arterial Disease among Patients with Chronic Kidney Disease

    OpenAIRE

    Chen, Jing; Mohler, Emile R.; Xie, Dawei; Shlipak, Michael G.; Townsend, Raymond R.; Appel, Lawrence J; Raj, Dominic S.; Ojo, Akinlolu O.; Schreiber, Martin J.; Strauss, Louise F.; Zhang, Xiaoming; Wang, Xin; He, Jiang; Hamm, L. Lee

    2012-01-01

    Patients with chronic kidney disease (CKD) have an increased risk of developing peripheral arterial disease (PAD). We examined the cross-sectional association between novel risk factors and prevalent PAD among patients with CKD. A total of 3,758 patients with an estimated glomerular filtration rate (eGFR) of 20-70 mL/min/1.73 m2 who participated in the chronic renal insufficiency cohort (CRIC) study were included in the current analysis. PAD was defined as an ankle-brachial index

  6. SHIFTWORK AS ONE OF RISK FACTORS OF ARTERIAL HYPERTENSION AND METABOLIC DISORDERS

    OpenAIRE

    2015-01-01

    Background. Shiftwork is considered as one of risk factors of arterial hypertension (HT) and metabolic disorders. Aim. To study effects of different types of shift plan on HT and the metabolic disorders development. Material and Methods. 1091 men were included in the study. Patients were split into subgroups according to age (20–29, 30–39, 40–49, 50–59 years old) and shift plan (steady or shiftable work schedule). HT (blood pressure >130/85 mm Hg), abdominal obesity (waist circumference &g...

  7. High Agatston Calcium Score of Intracranial Carotid Artery: A Significant Risk Factor for Cognitive Impairment.

    Science.gov (United States)

    Kao, Hung-Wen; Liou, Michelle; Chung, Hsiao-Wen; Liu, Hua-Shan; Tsai, Ping-Huei; Chiang, Shih-Wei; Chou, Ming-Chung; Peng, Giia-Sheun; Huang, Guo-Shu; Hsu, Hsian-He; Chen, Cheng-Yu

    2015-09-01

    The effect of intracranial internal carotid artery (ICA) calcification on cognitive impairment is uncertain. Our objective was to investigate whether intracranial ICA calcification is a significant cognitive predictor for cognitive impairment. Global cognition and degrees of intracranial ICA calcification of 579 subjects were assessed with Mini-Mental State Examination (MMSE) and Agatston calcium scoring method, respectively. Other risk factors for cognitive impairment, including age, education level, hypertension, diabetes mellitus, smoking, hyperlipidemia, and body mass index, were documented and analyzed for their associations with cognitive function. In univariate analyses, older age, lower education level, hypertension, diabetes mellitus, and higher intracranial ICA Agatston scores were significantly associated with cognitive impairment. In ordinal logistic regression, only age and total intracranial ICA Agatston score were significant risk factors for cognitive impairment. After adjustment for the other documented risk factors, subjects were 7% (95% CI: 5-10; P calcification on cognitive impairment. PMID:26426620

  8. Doppler Sonography Confirmation in Patients Showing Calcified Carotid Artery Atheroma in Panoramic Radiography and Evaluation of Related Risk Factors

    OpenAIRE

    2012-01-01

    Background and aims The purpose of this study was to identify patients at the risk of cerebrovascular attack (CVA) by detecting calcified carotid artery atheroma (CCAA) in panoramic radiography and evaluating their risk factors. Materials and methods A total of 960 panoramic radiographs of patients above 40 years old were evaluated. Doppler Sonography (DS) was performed for patients who showed calcified carotid artery atheroma (CCAA) in panoramic radiogra-phy in order to determine the presenc...

  9. Auto-motivación como factor de la competência emocional

    OpenAIRE

    Veiga-Branco, Augusta

    2011-01-01

    El estudio acede a los comportamientos y actitudes que identifican la Auto- Motivación como variable de competencia emocional (CE) del profesorado. Partiendo del constructo de la inteligencia emocional (Goleman, 1995, 1999), se ha desarohado un Estudio cuantitativo y cualitativo. Método: El primero, sobre las respuestas de una muestra de 464 profesores a la "Escala Veiga Blanco de CE". E el segundo, el cualitativo,, donde emerge una "teoría fundamentada" partiendo de los dis...

  10. Gender Differences in Coronary Artery Disease: Correlational Study on Dietary Pattern and Known Cardiovascular Risk Factors

    Directory of Open Access Journals (Sweden)

    Mahdi Najafi

    2013-12-01

    Full Text Available Background: The relationship between diet and cardiovascular risk factors in men and women with Coronary Artery Disease (CAD has been the subject of recent studies. We studied a group of Iranian CAD patients to analyze any relationship between diet and CAD risk factors based on gender. Methods: In this study, 461 consecutive patients were assessed before their planned isolated coronary artery bypass graft surgery. They were interviewed to obtain the quantity and components of nutrients and micronutrients based on a validated food frequency questionnaire. Diet scores were calculated in each dietary group and the total score was reported as the Mediterranean Diet Quality Index (Med-DQI. Physical activity was assessed using International Physical Activity Questionnaire (IPAQ. Functional class, EuroSCORE and the frequency of the known risk factors in the men and women were recorded as well. Results: The women were more likely than the men to present with obesity, diabetes mellitus, hypercholesterolemia, and hypertension (all Ps < 0.001. Also, the women had higher functional class and mean of EuroSCORE (P < 0.001 and P = 0.03. Only six women (5.7% reported to have regular physical activity. In addition, Women’s energy intake was more likely to be supplied through fat. Cereals, fruit, and vegetable consumption in both genders was within the safe recommended range, while olive and fish consumption was low in both sexes. MedDQI score was different between men and women with hypertension (P = 0.018 and obesity (P = 0.048. Conclusions: Modifiable classical risk factors for CAD, except for smoking, were more prevalent in women and were associated with their diet. Therefore, women probably need to maintain low calorie intake while improving physical activity and dietary patterns to decrease the frequency and severity of modifiable cardiac risk factors.

  11. The Prevalence and Awareness of Cardiometabolic Risk Factors in Southern Chinese Population with Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Xinrui Li

    2013-01-01

    Full Text Available Background. Cardiometabolic risk factors significantly accelerate the progression of coronary artery disease (CAD; however, whether CAD patients in South China are aware of the prevalence of these risk factors is not clear yet. Methods. The study consisted of 2312 in-admission CAD patients from 2008 to 2011 in South China. Disease history including hypertension, dyslipidemia, and diabetes was relied on patients' self-reported records. Physical and clinical examinations were tested to assess the real prevalence of the cardiometabolic risk factors. Results. 57.9% of CAD patients had more than 3 cardiometabolic risk factors in terms of the metabolic syndrome. The self-known and real prevalence of hypertension, diabetes, and dyslipidemia were 56.6%, 28.3%, and 25.1% and 91.3%, 40.9%, and 92.0%, respectively. The awareness rates were 64.4%, 66.3%, and 28.5% for hypertension, diabetes, and dyslipidemia. The prevalence of cardiometabolic risk factors was significantly different among gender and among disease status. Conclusions. Most CAD patients in South China had more than three cardiometabolic risk factors. However, the awareness rate of cardiometabolic diseases was low, especially for dyslipidemia. Strategies of routine physical examination programs are needed for the early detection and treatment of cardiometabolic risk factors in order to prevent CAD progression and prognosis.

  12. Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries

    DEFF Research Database (Denmark)

    Blædel, Martin; Sams, Anette; Boonen, Harrie C M; Sheykhzade, Majid

    UNLABELLED: This study investigated the effect of the metabolic syndrome associated risk factors hyperglycemia (glucose [Glc]), hyperinsulinemia (insulin [Ins]) and low-grade inflammation (tumor necrosis factor α [TNFα]) on the vasomotor responses of resistance arteries. Isolated small mesenteric...... arteries from 3-month-old Sprague-Dawley rats, were suspended for 21-23 h in tissue cultures containing either elevated Glc (30 mmol/l), Ins (100 nmol/l), TNFα (100 ng/ml) or combinations thereof. After incubation, the vascular response to noradrenaline (NA), phenylephrine, isoprenaline and NA in the...... presence of propranolol (10 µmol/l) was measured by wire myography. RESULTS: Arteries exposed only to combinations of the risk factors showed a significant 1.6-fold increase in the contractile NA sensitivity, which suggests that complex combinations of metabolic risk factors might lead to changes in...

  13. COMPORTAMIENTO DE PRÓTESIS DENTALES REMOVIBLES COMO FACTOR CAUSAL DE ESTOMATITIS SUB-PROTÉSICA: REPORTE DE UN CASO

    OpenAIRE

    Martha Leonor Rebolledo Cobos; Mayra Pastor Martinez

    2012-01-01

    La presencia de prótesis removibles en la cavidad bucal acompañada de condiciones como: deficiente adaptación y ajuste, poca higiene bucal, presencia de microorganismos, hábitos, vicios incluyendo factores sistémicos, corresponde un factor causal para la aparición de estomatitis sub-protésica (ESP). Esta entidad patológica se caracteriza por la presencia de lesiones inflamatorias eritematosas, asintomáticas, de mayor prevalencia en el maxilar y con predilección al sexo femenino. Su tratamient...

  14. Trastornos de la conducta alimentaria como factor de riesgo para osteoporosis Eating disorders as risk factors for osteoporosis

    Directory of Open Access Journals (Sweden)

    Ma Teresa Rivera-Gallardo

    2005-07-01

    Full Text Available Los trastornos de la conducta alimentaria son comunes en mujeres jóvenes con una prevalencia estimada de entre 4-5%. La pérdida de masa ósea es una complicación física de la anorexia nervosa y trastorno alimentario no especificado que afecta tanto a hueso cortical como trabecular. El efecto sinérgico de la desnutrición y la deficiencia de estrógenos produce una pérdida de masa ósea a través del desacoplamiento entre resorción osteoclástica y formación osteoblástica. La severidad varía dependiendo de la duración de la enfermedad, el peso menor alcanzado y la actividad física. La repercusión a largo plazo es evidente pues existe un incremento en el riesgo de fractura en las pacientes que han padecido anorexia nervosa. La primera línea de tratamiento para recuperar la masa ósea es la rehabilitación nutricia y un incremento de peso. La terapia de reemplazo hormonal podría ser efectiva si se combina con métodos anabólicos. Los términos osteopenia y osteoporosis fueron adoptados para definir la deficiencia de masa ósea en adultos. Los autores de las publicaciones que fueron revisadas utilizaron dichos términos para definir datos densitométricos en sujetos jóvenes que no han alcanzado la masa ósea pico. Sugerimos el término "hipo-osteogenesia" para definir el desarrollo deficiente de masa ósea en adolescentes o niños.Eating disorders (TCA per its abbreviation in Spanish are common in young women, with an estimated prevalence of 4-5%. One of the physical complications of eating disorders, especially anorexia nervosa (AN and eating disorder not otherwise specified (TANE is bone mass loss, which affects both cortical and trabecular bone. The synergistic effect of malnutrition and estrogen deficiency produces significant bone mass loss, resulting from the uncoupling of bone turnover characterized by a decrease in osteoblastic bone formation and an increase in osteclastic bone resorption. The mechanisms implied in the

  15. Factors Associated with Anxiety in Premature Coronary Artery Disease Patients: THC-PAC Study.

    Science.gov (United States)

    Abbasi, Seyed Hesameddin; Kassaian, Seyed Ebrahim; Sadeghian, Saeed; Karimi, Abbasali; Saadat, Soheil; Peyvandi, Flora; Jalali, Arash; Davarpasand, Tahereh; Akhondzadeh, Shahin; Shahmansouri, Nazila; Boroumand, Mohammad Ali; Lotfi-Tokaldany, Masoumeh; Amiri Abchouyeh, Maryam; Ayatollahzade Isfahani, Farah; Rosendaal, Frits

    2016-04-01

    Anxiety may negatively affect the course of coronary artery disease (CAD). The aim of this study was to assess which factors are associated with anxiety in young adults with CAD. A cohort of individuals with premature coronary artery disease was formed between 2004-2011, as the Tehran Heart Center's Premature Coronary Atherosclerosis Cohort (THC-PAC) study. Patients (men≤45-year-old, and women≤55-year-old) were visited between March 2013 and February 2014. All participants were examined, and their demographic, clinical, and laboratory data were collected. Then, all participants filled in the Beck Anxiety Inventory. Logistic regression models were used to identifying factors related to anxiety in both sexes. During the study, 708 patients (mean [SD] age: 45.3 [5.8] y, men:48.2%) were visited. Anxiety was present in 53.0% of participants (66.0% of women and 39.0% of men). The logistic regressions model showed that the associated factors for anxiety in men were opium usage (OR=1.89, 95% CI: 1.09-3.27), positive family history (OR=1.49, 95% CI:0.94-2.35), and creatinine serum level (OR=1.17, 95% CI:1.05-1.303); and in women were major adverse cardiac events (MACE) during follow-up (OR=2.30, 95% CI:1.25-4.23), hypertension (OR=1.71, 95% CI:1.07-2.73) and the duration of CAD (OR=0.99, 95% CI:0.98-1.00). In premature CAD patients, the determinants of anxiety seem to be different in each sex. Opium usage, positive family history of CAD, and creatinine serum levels in men, and MACE, hypertension, and duration of CAD in women appear the relevant factors in this regard. PMID:27309268

  16. Coronary artery calcium scores and cardiovascular risk factors in 31,545 asymptomatic Korean adults.

    Science.gov (United States)

    Jang, Shin Yi; Kim, Sung Mok; Sung, Jidong; Cho, Soo Jin; Choe, Yeon Hyeon

    2016-06-01

    The aims of this study were to identify the distribution of coronary artery calcium score (CACS) by age group and cardiovascular (CV) risk factors and to evaluate the association between CV risk factors and CACS classification in asymptomatic adults. The study included 31,545 asymptomatic Koreans, over 20 years of age with no previous history of malignancy, proven coronary artery disease, or stroke, who underwent CACS computed tomography at the Health Promotion Center, Samsung Medical Center, between January 2005 and June 2013. Mean (±SD) age was 53.8 (±8.5) years overall, 56.1 (±8.3) in men, and 53.3 (±8.5) in women. They were classified into five groups based on their resting CACS: none (CAC = 0), minimal (0  CAC). Older age groups exhibited higher CACS values. The proportion of CACS classification in our study was 55.5 % with no CACS, 9.5 % with minimal CACS, 19.8 % with mild CACS, 10.8 % with moderate CACS, and 4.3 % with extensive CACS. Adjusted odds ratios (ORs) were calculated for CV risk factors to determine their association with CACS. When analyzed according to sex, in males, the adjusted OR for CACS increased with the presence of hypertension (HT), diabetes mellitus (DM), obesity, chronic kidney disease, and smoking status. While, in females, the adjusted OR for CACS increased with the presence of HT, DM, and obesity. CV risk factors appear to be significantly associated with CACS in the Korean population. PMID:27119164

  17. An evaluation of potassium ions as endothelium-derived hyperpolarizing factor in porcine coronary arteries.

    Science.gov (United States)

    Bény, J L; Schaad, O

    2000-11-01

    In the rat hepatic artery, the endothelium-derived hyperpolarizing factor (EDHF) was identified as potassium. Potassium hyperpolarizes the smooth muscles by gating inward rectified potassium channels and by activating the sodium-potassium adenosine triphosphatase (Na(+)-K(+)ATPase). Our goal was to examine whether potassium could explain the EDHF in porcine coronary arteries. On coronary strips, the inhibition of calcium-dependent potassium channels with 100 nM apamin plus 100 microM charibdotoxin inhibited the endothelium-dependent relaxations, produced by 10 nM substance P and 300 nM bradykinin and resistant to nitro-L-arginine and indomethacin. The scavenging of potassium with 2 mM Kryptofix 2.2.2 abolished the endothelium-dependent relaxations produced by the kinins and resistant to nitro-L-arginine and indomethacin. Forty microM 18alpha glycyrrethinic acid or 50 microM palmitoleic acid, both uncoupling agents, did not inhibit these kinin relaxations. Therefore, EDHF does not result from an electrotonic spreading of an endothelial hyperpolarization. Barium (0.3 nM) did not inhibit the kinin relaxations resistant to nitro-L-arginine and indomethacin. Therefore, EDHF does not result from the activation of inward rectified potassium channels. Five hundred nM ouabain abolished the endothelium-dependent relaxations resistant to nitro-L-arginine and indomethacin without inhibiting the endothelium-derived NO relaxation. The perifusion of a medium supplemented with potassium depolarized and contracted a coronary strip; however, the short application of potassium hyperpolarized the smooth muscles. These results are compatible with the concept that, in porcine coronary artery, the EDHF is potassium released by the endothelial cells and that this ion hyperpolarizes and relaxes the smooth muscles by activating the Na(+)-K(+)ATPase. PMID:11053218

  18. Predictive Factors of In-Stent Restenosis in Renal Artery Stenting: A Retrospective Analysis

    International Nuclear Information System (INIS)

    Purpose. To retrospectively evaluate the role of clinical and procedural factors in predicting in-stent restenosis in patients with renovascular disease treated by renal artery stenting. Methods. From 1995 to 2002, 147 patients underwent renal artery stenting for the treatment of significant ostial atherosclerotic stenosis. Patients underwent strict clinical and color-coded duplex ultrasound follow-up. Ninety-nine patients (111 stents), with over 6 months of continuous follow-up (mean 22±12 months, range 6-60 months), were selected and classified according to the presence (group A, 30 patients, 32 lesions) or absence (group B, 69 patients, 79 lesions) of significant in-stent restenosis. A statistical analysis was performed to identify possible preprocedural and procedural predictors of restenosis considering the following data: sex, age, smoking habit, diabetes mellitus, hypertension, serum creatinine, cholesterol and triglyceride levels, renal artery stenosis grade, and stent type, length and diameter. Results. Comparing group A and B patients (χ2 test), a statistically significant relation was demonstrated between stent diameter and length and restenosis: the risk of in-stent restenosis decreased when the stent was ≥6 mm in diameter and between 15 and 20 mm in length. This finding was confirmed by multiple logistic regression analysis. Stent diameter and length were proved to be significantly related to in-stent restenosis also when evaluating only patients treated by Palmaz stent (71 stents). Conclusion. Although it is based on a retrospective analysis, the present study confirms the importance of correct stent selection in increasing long-term patency, using stents of at least 6 mm in diameter and with a length of approximately 15-20 mm

  19. Detection of Altered Risk Factors in Hospitalized Patients with Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Avany Fernandes Pereira

    2002-09-01

    Full Text Available OBJECTIVE: To assess biochemical, anthropometric, and dietary variables considered risk factors for coronary artery disease. METHODS: Using anthropometrics, dietary allowance, and blood biochemistry, we assessed 84 patients [54 males (mean age of 55± 8 years and 30 females (mean age of 57±7 years], who had severe ( > or = 70% coronary artery obstruction and nonsevere forms of coronary artery disease determined by cardiac catheterization. The severe form of the disease prevailed in 70% of the males and 64% of the females, and a high frequency of familial antecedents (92% ' 88% and history of acute myocardial infarction (80% ' 70% were observed. Smoking predominated among males (65% and diabetes mellitus among females (43%. RESULTS: Males and females had body mass index and body fat above the normal values. Females with nonsevere lesions had HDL > 35 mg/dL, and this constituted a discriminating intergroup indicator. Regardless of the severity of the disease, hyperglycemia and hypertriglyceridemia were found among females, and cholesterolemia > 200 mg/dL in both sexes, but only males had LDL fraction > 160 mg/dL and homocysteine > 11.7 mmol/L. The male dietary allowance was inadequate in nutrients for homocysteine metabolism and in nutrients with an antioxidant action, such as the vitamins B6, C, and folate. Individuals of both sexes had a higher lipid and cholesterol intake and an inadequate consumption of fiber. The diet was classified as high-protein, high-fat, and low-carbohydrate. CONCLUSION: The alterations found had no association with the severity of lesions, indicating the need for more effective nutritional intervention.

  20. La mediocridad como factor de violencia: entre la Ética y la Moral

    Directory of Open Access Journals (Sweden)

    Ricardo Romero Urrego

    2001-12-01

    Full Text Available En las circunstancias actuales que vive Colombia, ha venido haciendo carrera la actitud de no responsabilizarse por las propias acciones. Asumir que son otros los que deben hacer las cosas y tomar las decisiones. Esta actitud va reflejándose cada vez más como mediocridad y se expresa en no pocos confines de la vida cotidiana, en el trabajo, en el estudio, en todos los escenarios. Esta mediocridad contribuye a generar violencia social del más variado tipo.

  1. La obesidad como factor de riesgo en el desarrollo de cáncer

    OpenAIRE

    Deissy Herrera-Covarrubias; Genaro Alfonso Coria-Avila; Cynthia Fernández-Pomares; Aranda-Abreu, Gonzalo E; Jorge Manzo Denes; María Elena Hernández

    2015-01-01

    De acuerdo con la Organización Mundial de la Salud, cada año fallecen 3,4 millones de personas adultas por consecuencias del sobrepeso u obesidad. Personas con un índice de masa corporal superior a 30, presentan cierto aumento en la incidencia de algunas enfermedades entre las que se encuentran algunos tipos de cánceres. En esta revisión de tipo narrativa se aborda el papel que tiene el tejido adiposo como modulador del sistema endocrino y facilitador de la inflamación crónica subclínica. Se ...

  2. La mediocridad como factor de violencia: entre la ética y la moral

    OpenAIRE

    Ricardo Romero Urrego

    2011-01-01

    En las circunstancias actuales que vive Colombia, ha venido haciendo carrera la actitud de no responsabilizarse por las propias acciones. Asumir que son otros los que deben hacer las cosas y tomar las decisiones. Esta actitud va reflejándose cada vez más como mediocridad y se expresa en no pocos confines de la vida cotidiana, en el trabajo, en el estudio, en todos los escenarios. Esta mediocridad contribuye a generar violencia social del más variado tipo.

  3. El clima familiar como factor determinante en la conformación de la empresa familiar

    OpenAIRE

    Carrasco Martínez, Antonio; Olaz Capitán, Ángel José; Ortíz García, Pilar

    2013-01-01

    En la actualidad la empresa familiar se enfrenta a la necesidad de optimizar su funcionamiento y alcanzar su máxima eficiencia organizativa. Los recursos con los que cuenta la empresa para llevar a cabo este cometido, siempre complejo por definición, son susceptibles de convertirse en una oportunidad en las empresas familiares. En este sentido, los recursos familiares, tales como el grado de cohesión interno y el compromiso tienen su traducción en el clima familiar. Este ...

  4. La diversificación en el medio rural como factor de desarrollo

    OpenAIRE

    Mercedes Millán Escriche

    2002-01-01

    La diversificación de las rentas agrarias está considerada como una de las vías fundamentales para conseguir el desarrollo de numerosos espacios rurales europeos y, de modo muy particular, de aquellos que por su especial situación de declive precisan un motor de reactivación más allá de las actividades tradicionales del medio. Entre la gama de posibilidades, dado el fracaso de las inversiones exógenas, el turismo es uno de los instrumentos a los que se otorga mayor eficacia por...

  5. Multiple presence of prothrombotic risk factors in Croatian children with arterial ischemic stroke and transient ischemic attack

    OpenAIRE

    Leniček Krleža, Jasna; Đuranović, Vlasta; Bronić, Ana; Coen Herak, Desiree; Mejaški-Bošnjak, Vlatka; Zadro, Renata

    2013-01-01

    Aim To determine the frequency of inherited and acquired prothrombotic risk factors in children with arterial ischemic stroke (AIS) and transient ischemic attacks (TIA) in Croatia. Methods We investigated 14 prothrombotic risk factors using blood samples from 124 children with AIS or TIA and 42 healthy children. Prothrombotic risk factors were classified into five groups: natural coagulation inhibitors (antithrombin, protein C, protein S), blood coagulation factors (FV Leiden and FII 20210), ...

  6. La crisis de los frutos saludables como factor determinante de la "revolución de los comuneros"

    Directory of Open Access Journals (Sweden)

    Luis Rubén Pérez-Pinzón

    2014-07-01

    Full Text Available El artículo reflexiona acerca de los discursos e imaginarios tradicionales sobre la Revolución de los Comuneros en Colombia y los contrasta con los análisis socioculturales y las descripciones etiopatológicas de dos curas párrocos ilustrados y protomédicos del siglo XVIII en la Nueva Granada con el propósito de demostrar como factores determinantes de la revuelta popular de 1781 las dificultades monopólicas y tributarias para acceder a las yerbas, frutas y bebidas populares consideradas medicinales y saludables, así como fuentes del bienestar ambiental y la prosperidad socioeconómica de los más pobres.

  7. Krüppel-like Factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension

    Directory of Open Access Journals (Sweden)

    Paulin Roxane

    2011-09-01

    Full Text Available Background Pulmonary arterial hypertension (PAH is a vascular remodeling disease characterized by enhanced proliferation of pulmonary artery smooth muscle cell (PASMC and suppressed apoptosis. This phenotype has been associated with the upregulation of the oncoprotein survivin promoting mitochondrial membrane potential hyperpolarization (decreasing apoptosis and the upregulation of growth factor and cytokines like PDGF, IL-6 and vasoactive agent like endothelin-1 (ET-1 promoting PASMC proliferation. Krüppel-like factor 5 (KLF5, is a zinc-finger-type transcription factor implicated in the regulation of cell differentiation, proliferation, migration and apoptosis. Recent studies have demonstrated the implication of KLF5 in tissue remodeling in cardiovascular diseases, such as atherosclerosis, restenosis, and cardiac hypertrophy. Nonetheless, the implication of KLF5 in pulmonary arterial hypertension (PAH remains unknown. We hypothesized that KLF5 up-regulation in PAH triggers PASMC proliferation and resistance to apoptosis. Methods and results We showed that KFL5 is upregulated in both human lung biopsies and cultured human PASMC isolated from distal pulmonary arteries from PAH patients compared to controls. Using stimulation experiments, we demonstrated that PDGF, ET-1 and IL-6 trigger KLF-5 activation in control PASMC to a level similar to the one seen in PAH-PASMC. Inhibition of the STAT3 pathway abrogates KLF5 activation in PAH-PASMC. Once activated, KLF5 promotes cyclin B1 upregulation and promotes PASMC proliferation and triggers survivin expression hyperpolarizing mitochondria membrane potential decreasing PASMC ability to undergo apoptosis. Conclusion We demonstrated for the first time that KLF5 is activated in human PAH and implicated in the pro-proliferative and anti-apoptotic phenotype that characterize PAH-PASMC. We believe that our findings will open new avenues of investigation on the role of KLF5 in PAH and might lead to the

  8. Frequency of coronary artery disease (cad) risk factors in armed forces

    International Nuclear Information System (INIS)

    To determine the frequency of risk factors of coronary artery disease (CAD) in apparently healthy soldiers of Pakistan Armed Forces. Study Design: Cross sectional descriptive study. Place and Duration of Study: Department of medicine, CMH Okara from July 2012 to Dec 2012. Patients and Methods: The study included 2215 male currently serving soldiers in age range of 18 to 52 years by consecutive sampling. Relevant history, body mass index (BMI), waist circumference (WC) and blood pressure (BP) of each subject were recorded. BMI > 25 kg/m/sup 2/ and WC > 90 cm was considered obesity and abdominal obesity respectively. BP > 140/90 mmHg was defined as hypertension. All the participants of study underwent blood glucose fasting, blood glucose random, ECG recording, personality assessment and lipid profile. Risk estimation was done using Eric Brittain scoring system. Results: In our study group 95.5% patients were having at least 1 risk factor of CAD, 54 % were having 2 to 4 risk factors while 3.93% had > 4 risk factors. Risk estimation of CAD using Eric Brittain scoring system showed that a large proportion of study group had high probability of developing ischemic heart disease in next 6 years. Conclusion: A large proportion of our soldiers are harboring risk of CAD due to increase in frequency of 8 conventional CAD risk factors especially obesity. (author)

  9. Prevalence and Risk Factors of Carotid Vessel Wall Inflammation in Coronary Artery Disease Patients

    Science.gov (United States)

    Bucerius, Jan; Duivenvoorden, Raphaël; Mani, Venkatesh; Moncrieff, Colin; Rudd, James H. F.; Calcagno, Claudia; Machac, Josef; Fuster, Valentin; Farkouh, Michael E.; Fayad, Zahi A.

    2014-01-01

    OBJECTIVES We investigated the prevalence and clinical risk factors of carotid vessel wall inflammation by means of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in a population consisting of coronary artery disease (CAD) patients. BACKGROUND The atherosclerotic disease process is characterized by infiltration and retention of oxidized lipids in the artery wall, triggering a disproportionate inflammatory response. Efforts have been made to use noninvasive imaging to quantify this inflammatory response in the vessel wall. Recently, carotid FDG-PET has been shown to reflect the metabolic rate of glucose, a process known to be enhanced in inflamed tissue. METHODS Carotid inflammation was quantified in 82 CAD patients (age 62 ± 10 years) as the maximum target-to-background ratio (wholevesselTBRmax). Furthermore, we assessed the maximal standardized uptake value values (wholevesselSUVmax), the single hottest segment (SHS), and the percent active segments (PAS) of the FDG uptake in the artery wall, measured by FDG-PET. RESULTS Whole-vessel TBRmax > 1.8 was present in 67%, > 2.0 in 39%, > 2.2 in 23%, and > 2.4 in 12% of the population. Multiple linear regression analysis with backward elimination revealed that body mass index (BMI) ≥ 30 kg/m2 (p 65 years (p = 0.01), smoking (p = 0.02), and hypertension (p = 0.01) were associated with wholevesselTBRmax. The number of components of the metabolic syndrome was also associated with wholevesselTBRmax (p = 0.02). In similar analyses, wholevesselSUVmax was associated with BMI ≥30 kg/m2 (p 65 years (p = 0.004), male gender (p = 0.02), and hypertension (p = 0.04); SHS with BMI ≥30 kg/m2 (p 65 years (p = 0.02), smoking (p = 0.04), and hypertension (p = 0.05); PAS with BMI ≥30 kg/m2 (p = 0.001), smoking (p = 0.03), and hypertension (p = 0.01). CONCLUSIONS Carotid inflammation as revealed by FDG-PET is highly prevalent in the CAD population and is associated with obesity, age over 65 years, history of

  10. Increased aortic stiffness and related factors in patients with peripheral arterial disease.

    Science.gov (United States)

    Catalano, Mariella; Scandale, Giovanni; Carzaniga, Gianni; Cinquini, Michela; Minola, Marzio; Dimitrov, Gabriel; Carotta, Maria

    2013-10-01

    A number of conditions have been associated with functional changes of large arteries. The aim of this study was to evaluate the factors associated with aortic stiffness in patients with peripheral arterial disease (PAD). The authors studied 86 patients with PAD (ankle-brachial pressure index [ABPI] ≤0.9) and 86 controls. Aortic stiffness was determined by pulse wave velocity (aPWV) using applanation tonometry. In PAD patients, aPWV was higher compared with controls (11 ± 3 vs 9.8 ± 1.8; P=.002). In multiple regression analysis, aPWV was independently associated with pulse pressure (β=0.05, P=.01) in the PAD patients and with age in the control group (β=0.08, P=.0005). The results of this study confirm an aPWV increase in patients with PAD and emphasize the association between blood pressure and aPWV. Further studies are necessary to assess whether higher aortic stiffening adds prognostic value to ABPI, which is the most powerful prognostic indicator in PAD. PMID:24088278

  11. Angiographically Negative Acute Arterial Upper and Lower Gastrointestinal Bleeding: Incidence, Predictive Factors, and Clinical Outcomes

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin Hyoung; Shin, Ji Hoon; Yoon, Hyun Ki; Chae, Eun Young; Myung, Seung Jae; Ko, Gi Young; Gwon, Dong Il; Sung, Kyu Bo [Asan Medical Center, Seoul (Korea, Republic of)

    2009-08-15

    To evaluate the incidence, predictive factors, and clinical outcomes of angiographically negative acute arterial upper and lower gastrointestinal (GI) bleeding. From 2001 to 2008, 143 consecutive patients who underwent an angiography for acute arterial upper or lower GI bleeding were examined. The angiographies revealed a negative bleeding focus in 75 of 143 (52%) patients. The incidence of an angiographically negative outcome was significantly higher in patients with a stable hemodynamic status (p < 0.001), or in patients with lower GI bleeding (p = 0.032). A follow-up of the 75 patients (range: 0-72 months, mean: 8 {+-} 14 months) revealed that 60 of the 75 (80%) patients with a negative bleeding focus underwent conservative management only, and acute bleeding was controlled without rebleeding. Three of the 75 (4%) patients underwent exploratory surgery due to prolonged bleeding; however, no bleeding focus was detected. Rebleeding occurred in 12 of 75 (16%) patients. Of these, six patients experienced massive rebleeding and died of disseminated intravascular coagulation within four to nine hours after the rebleeding episode. Four of the 16 patients underwent a repeat angiography and the two remaining patients underwent a surgical intervention to control the bleeding. Angiographically negative results are relatively common in patients with acute GI bleeding, especially in patients with a stable hemodynamic status or lower GI bleeding. Most patients with a negative bleeding focus have experienced spontaneous resolution of their condition.

  12. Factor XIII B Subunit Polymorphisms and the Risk of Coronary Artery Disease

    Science.gov (United States)

    Mezei, Zoltán A.; Bereczky, Zsuzsanna; Katona, Éva; Gindele, Réka; Balogh, Emília; Fiatal, Szilvia; Balogh, László; Czuriga, István; Ádány, Róza; Édes, István; Muszbek, László

    2015-01-01

    The aim of the case-control study was to explore the effect of coagulation factor XIII (FXIII) B subunit (FXIII-B) polymorphisms on the risk of coronary artery disease, and on FXIII levels. In the study, 687 patients admitted for coronary angiography to investigate suspected coronary artery disease and 994 individuals representing the Hungarian population were enrolled. The patients were classified according to the presence of significant coronary atherosclerosis (CAS) and history of myocardial infarction (MI). The F13B gene was genotyped for p.His95Arg and for intron K nt29756 C>G polymorphisms; the latter results in the replacement of 10 C-terminal amino acids by 25 novel amino acids. The p.His95Arg polymorphism did not influence the risk of CAS or MI. The FXIII-B intron K nt29756 G allele provided significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. However, this effect prevailed only in the presence of the FXIII-A Leu34 allele, and a synergism between the two polymorphisms was revealed. Carriers of the intron K nt29756 G allele had significantly lower FXIII levels, and FXIII levels in the lower tertile provided significant protection against MI. It is suggested that the protective effect of the combined polymorphisms is related to decreased FXIII levels. PMID:25569091

  13. Factor XIII B Subunit Polymorphisms and the Risk of Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Zoltán A. Mezei

    2015-01-01

    Full Text Available The aim of the case-control study was to explore the effect of coagulation factor XIII (FXIII B subunit (FXIII-B polymorphisms on the risk of coronary artery disease, and on FXIII levels. In the study, 687 patients admitted for coronary angiography to investigate suspected coronary artery disease and 994 individuals representing the Hungarian population were enrolled. The patients were classified according to the presence of significant coronary atherosclerosis (CAS and history of myocardial infarction (MI. The F13B gene was genotyped for p.His95Arg and for intron K nt29756 C>G polymorphisms; the latter results in the replacement of 10 C-terminal amino acids by 25 novel amino acids. The p.His95Arg polymorphism did not influence the risk of CAS or MI. The FXIII-B intron K nt29756 G allele provided significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. However, this effect prevailed only in the presence of the FXIII-A Leu34 allele, and a synergism between the two polymorphisms was revealed. Carriers of the intron K nt29756 G allele had significantly lower FXIII levels, and FXIII levels in the lower tertile provided significant protection against MI. It is suggested that the protective effect of the combined polymorphisms is related to decreased FXIII levels.

  14. Transcatheter arterial Chemoembolization for infiltrative hepatocellular carcinoma: Clinical safety and efficacy and factors influencing patient survival

    Energy Technology Data Exchange (ETDEWEB)

    Han, Kichang; Kim, Jin Hyoung; Yoon, Hee Mang; Kim, Eun Joung; Gwon, Dong Il; Ko, Gi Young; Yoon, Hyun Ki; Ko, Heung Kyu [Dept. of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul (Korea, Republic of)

    2014-08-15

    To evaluate the safety and efficacy of transcatheter arterial chemoembolization (TACE) in patients with infiltrative hepatocellular carcinoma (HCC) and to identify the prognostic factors associated with patient survival. Fifty two patients who underwent TACE for infiltrative HCC were evaluated between 2007 and 2010. The maximum diameter of the tumors ranged from 7 cm to 22 cm (median 15 cm). Of 46 infiltrative HCC patients with portal vein tumor thrombosis, 32 patients received adjuvant radiation therapy for portal vein tumor thrombosis after TACE. The tumor response by European Association for the Study of the Liver criteria was partial in 18%, stable in 47%, and progressive in 35% of the patients. The median survival time was 5.7 months (Kaplan-Meier analysis). The survival rates were 48% at six months, 25% at one year, and 12% at two years. In the multivariable Cox regression analysis, Child-Pugh class (p = 0.02), adjuvant radiotherapy (p 0.003) and tumor response after TACE (p = 0.004) were significant factors associated with patient survival. Major complications occurred in nine patients. The major complication rate was significantly higher in patients with Child-Pugh B than in patients with Child-Pugh A (p = 0.049, x{sup 2} test). Transcatheter arterial chemoembolization can be a safe treatment option in infiltrative HCC patients with Child Pugh class A. Child Pugh class A, radiotherapy for portal vein tumor thrombosis after TACE and tumor response are good prognostic factors for an increased survival after TACE in patients with infiltrative HCCs.

  15. Renal artery stenosis in kidney transplants: assessment of the risk factors

    Directory of Open Access Journals (Sweden)

    Etemadi J

    2011-08-01

    Full Text Available Jalal Etemadi1, Khosro Rahbar2, Ali Nobakht Haghighi2, Nazila Bagheri2, Kianoosh Falaknazi2, Mohammad Reza Ardalan1, Kamyar Ghabili3, Mohammadali M Shoja31Department of Nephrology, Dialysis and Transplantation, Tabriz University of Medical Sciences, Tabriz, 2Department of Nephrology, Shaheed Beheshti University of Medical Sciences, Tehran, 3Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IranBackground: Transplant renal artery stenosis (TRAS is an important cause of hypertension and renal allograft dysfunction occurring in kidney transplant recipients. However, conflicting predisposing risk factors for TRAS have been reported in the literature.Objective: The aim of the present study was to assess the potential correlation between possible risk factors and TRAS in a group of living donor renal transplant recipients 1 year after the renal transplantation.Methods: We evaluated the presence of renal artery stenosis in 16 recipients who presented with refractory hypertension and/or allograft dysfunction 1 year after renal transplantation. Screening for TRAS was made by magnetic resonance angiography and diagnosis was confirmed by conventional renal angiography. Age, gender, history of acute rejection, plasma lipid profile, serum creatinine, blood urea nitrogen, serum uric acid, calcium phosphate (CaPO4 product, alkaline phosphatase, fasting blood sugar, hemoglobin, and albumin were compared between the TRAS and non-TRAS groups.Results: Of 16 kidney transplant recipients, TRAS was diagnosed in three patients (two men and one woman. High levels of calcium, phosphorous, CaPO4 product, and low-density lipoprotein (LDL cholesterol were significantly correlated with the risk of TRAS 1 year after renal transplantation (P < 0.05. Serum level of uric acid tended to have a significant correlation (P = 0.051.Conclusion: Correlation between high CaPO4 product, LDL cholesterol, and perhaps uric acid and TRAS in living

  16. Factores de riesgo de la hipertensión arterial y la salud cardiovascular en estudiantes universitarios

    OpenAIRE

    Figueroa López, Carlos Gonzalo; Ramos del Rio, Bertha

    2006-01-01

    El objetivo fue determinar los factores de riesgo de la hipertensión arterial en estudiantes universitarios. Participaron 110 estudiantes normotensos divididos en: a) grupo de casos (N= 52), con antecedente familiar de hipertensión, y b) grupo de controles (N= 58), sin antecedente familiar de hipertensión. En los dos grupos se aplicaron el Cuestionario para detectar antecedentes familiares de hipertensión arterial y el Inventario de Factores de Riesgo de Hipertensión (IFRH) (Grijalva, 1992). ...

  17. Factores de riesgo de la hipertensión arterial y la salud cardiovascular en estudiantes universitarios

    OpenAIRE

    Figueroa López, Carlos Gonzalo; Ramos del Rio, Bertha

    2006-01-01

    El objetivo fue determinar los factores de riesgo de la hiperten-sión arterial en estudiantes universitarios. Participaron 110 estudiantes normotensos divididos en: a) grupo de casos (N= 52), con antecedente familiar de hipertensión, y b) grupo de controles (N= 58), sin antecedente familiar de hipertensión. En los dos grupos se aplicaron el Cuestionario para detectar antecedentes familiares de hipertensión arterial y el Inventa-rio de Factores de Riesgo de Hipertensión (IFRH) (Grijalva, 1992)...

  18. Trastornos de la conducta alimentaria como factor de riesgo para osteoporosis

    OpenAIRE

    Jorge Armando Barriguete-Meléndez; Ma Teresa Rivera-Gallardo; Ma del Socorro Parra-Cabrera

    2005-01-01

    Los trastornos de la conducta alimentaria son comunes en mujeres jóvenes con una prevalencia estimada de entre 4-5%. La pérdida de masa ósea es una complicación física de la anorexia nervosa y trastorno alimentario no especificado que afecta tanto a hueso cortical como trabecular. El efecto sinérgico de la desnutrición y la deficiencia de estrógenos produce una pérdida de masa ósea a través del mdesacoplamiento entre resorción osteoclástica y formación osteoblástica. La severidad varía depend...

  19. Espessamento médio-intimal na origem da artéria subclávia direita como marcador precoce de risco cardiovascular Intima-media thickness in the origin of right subclavian artery as an early marker of cardiovascular risk

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Engelhorn

    2006-11-01

    Full Text Available OBJETIVO: O espessamento médio-intimal (EMI na artéria carótida comum é considerado fator de risco cardiovascular e marcador de doença arterial coronariana precoce. O objetivo deste trabalho foi investigar a existência de correlação entre o EMI nas artérias carótidas e na origem da artéria subclávia direita, e avaliar o EMI na artéria subclávia como um marcador mais precoce para avaliação de risco cardiovascular. MÉTODOS: Cento e seis pacientes consecutivos, 52 homens e 54 mulheres, com média de idade de 51 anos, foram submetidos à avaliação das artérias carótidas e subclávia direita pela ultra-sonografia vascular com Doppler colorido. Para avaliar a associação entre EMI das artérias carótidas e subclávia direita calcularam-se o coeficiente de correlação de Pearson e o intervalo de 95% de confiança para esse coeficiente. A qualidade da medida do EMI da artéria subclávia direita para diagnóstico de espessamento precoce, considerando-se o espessamento da carótida como padrão de referência (> 0,8 mm, foi descrita por valores de sensibilidade, especificidade, valor preditivo positivo, valor preditivo negativo e acurácia. Pontos de corte para o EMI da artéria subclávia foram sugeridos pela Curva ROC. Valores de p 0,8 mm. O valor médio de EMI obtido na artéria carótida foi de 0,87 mm (DP = 0,23 e na artéria subclávia direita foi de 1,17 mm (DP = 0,46, com coeficiente de correlação de 0,31 (95% IC: 0,12 ; 0,47. A avaliação pela curva ROC demonstrou um valor de corte de 0,7 mm para EMI da artéria subclávia direita, tendo como padrão de referência o valor de corte de EMI da artéria carótida de 0,8 mm (sensibilidade 91%, especificidade 27%, VPP 66%, VPN 65% e acurácia 66%. CONCLUSÃO: Existe boa correlação entre o EMI das artérias carótidas e da artéria subclávia direita. O EMI pode ser detectado mais precocemente na artéria subclávia do que nas carótidas, com valor de corte de 0,7 mm. O

  20. Prevalence of coronary artery disease risk factors in Iran: a population based survey

    Directory of Open Access Journals (Sweden)

    Gafarzadeh Motlag A

    2007-10-01

    Full Text Available Abstract Background Coronary artery disease (CAD is a leading cause of mortality, morbidity, and disability with high health care cost in Iran. It accounts for nearly 50 percent of all deaths per year. Yet little is known about CAD and CAD risk factors in the Iranian population. We aimed to assess the prevalence of different CAD risk factors in an Iranian population. Methods A descriptive cross sectional survey was conducted involving 3000 healthy adults at 18 years of age or above who were recruited with cluster random sampling. Demographic data and risk factors were determined by taking history, physical examination and laboratory tests. Results The average age was 36.23 ± 15.26. There was 1381 female (46% and 1619 male (54% out of which 6.3% were diabetic, 21.6% were smoker, and 15% had positive familial heart disease history. 61% had total cholesterol level > 200 mg/dL, 32% triglyceride > 200 mg/dl, 47.5% LDL-c > 130 mg/dl, 5.4% HDL-c 140 mmHg, 9.1% diastolic blood pressure > 90 mmHg and 87% of them were physically inactive. Conclusion Clinical and Para-clinical data indicated that Iranian adult population are of a high level of CAD risk factors, which may require urgent decision making to address national control measures regarding CAD.

  1. Kale Juice Improves Coronary Artery Disease Risk Factors in Hypercjlolesterolemiic Men

    Institute of Scientific and Technical Information of China (English)

    SOO YEON KIM; SUN YOON; SOO MI KWON; KYE SOOK PARK; YANG CHA LEE-KIM

    2008-01-01

    Objective To evaluate the effect of 3-month kale(Brassica oleracea acephala)iuice supplementation on coronary artery disease risk factors among hypercholesterolemic men.Methods Thkty-two men with hypercholesterolemia (>200 mg/dL)were recruited after annual health examinations among the faculty and staff at university.The subijects consumed 150 mL of kale iuice per day for a 12-week intervention period.Dietary and anthropomeu-ic assessments were performed and blood samples were collected to evaluate biochemical profdes before and after supplementation.Results Serum concentrations of HDL-cholesterol,and HDL-to LDL-cholesterol ratio were significantly increased by 27%(P<0.0001)and 52%(P<0.0001),respectively.The LDL-cholesterol concentration and the atherogenic index were significantly reduced by 1O%(P=0.O007)and 24.2%(P<0.0001),respectively without affecting body mass index,waist and hip circumferences,or nutrient intakes after three months of supplementation.While there was no difference in the concentration of malondialdehvde,significant increase in glutathione peroxidase activity(P=0.0005)were accompanied by a significant increase in the serom selenium level(P=0.0132).It was also foand that the responses of these risk factors to kale inice administration were dependent on smoking status.Conelusion Regular meals supplementation with kale juice can favorably influence serum lipid profiles and antioxidant systems.and hence contribute to reduce the risks of coronary artery disease in male subjects with hyperlipidemia.

  2. Trastornos de la conducta alimentaria como factor de riesgo para osteoporosis Eating disorders as risk factors for osteoporosis

    OpenAIRE

    Ma Teresa Rivera-Gallardo; Ma del Socorro Parra-Cabrera; Jorge Armando Barriguete-Meléndez

    2005-01-01

    Los trastornos de la conducta alimentaria son comunes en mujeres jóvenes con una prevalencia estimada de entre 4-5%. La pérdida de masa ósea es una complicación física de la anorexia nervosa y trastorno alimentario no especificado que afecta tanto a hueso cortical como trabecular. El efecto sinérgico de la desnutrición y la deficiencia de estrógenos produce una pérdida de masa ósea a través del desacoplamiento entre resorción osteoclástica y formación osteoblástica. La severidad varía dependi...

  3. El contexto como factor del aprendizaje autorregulado en la educación superior

    Directory of Open Access Journals (Sweden)

    Florencia Teresita Daura

    2013-04-01

    Full Text Available El presente trabajo analiza la influencia que tiene el entorno sobre el desarrollo del aprendizaje autorregulado en los estudiantes universitarios y la responsabilidad que tiene el docente de aprender a enseñar; se describen los resultados de un estudio en curso, obtenidos a partir de la observación de documentos de cátedra y de clases desarrolladas en el programa de Medicina de una universidad privada argentina. Dicho análisis se realizó a partir del modelo ofrecido por la Teoría Fundamentada con el objeto de elaborar un marco teórico que ayude a comprender cómo se desenvuelve el vínculo entre el docente y los estudiantes, cuáles son las estrategias didácticas utilizadas en el aula para favorecer el desarrollo del AAR y qué características tiene el proceso autorregulatorio efectuado por la cátedra. Se llega a la conclusión que tanto el estudiante como el profesor deben reconocer sus posiciones y entender las características del contexto en el que se encuentran para generar un mejor aprendizaje.

  4. El bilingüismo como factor de protección en el envejecimiento cognitivo

    Directory of Open Access Journals (Sweden)

    Daniel Adrover-Roig

    2009-12-01

    Full Text Available El control atencional permite a los bilingües utilizar ambos lenguajes de forma alternante minimizando las intrusiones de una lengua en la otra. En el presente trabajo se revisan de forma exhaustiva las evidencias que han puesto de manifiesto tanto una mayor capacidad de control cognitivo en sujetos bilingües, en especial en personas mayores, como su implicación en el deterioro cognitivo asociado a la edad. Para ello se reportan resultados de estudios conductuales y de neuroimagen, los cuales han empleado diversos paradigmas que implican resolución de la interferencia, entre otros. Posteriormente se establece un vínculo con la teoría de la reserva cognitiva, se discute el escaso protagonismo del bilingüismo en los modelos sobre envejecimiento cognitivo y se perfilan futuros campos de estudio y nuevas variables a considerar. Dado el creciente interés en la relación entre la función cognitiva y el cambio neural, se proponen los candidatos neurales que podrían dar cuenta de la “ventaja bilingüe”, en especial en la capacidad de control de la interferencia. Palabras clave: envejecimiento, bilingüismo, control atencional, reserva cognitiva.

  5. The prognosis and prognostic risk factors of patients with hepatic artery complications after liver transplantation treated with the interventional techniques

    International Nuclear Information System (INIS)

    Objective: To investigate the prognosis and prognostic risk factors of hepatic artery complications after orthotopic liver transplantation (OLT) treated with the interventional techniques. Methods: The clinical data of 21 patients with hepatic artery complication after liver transplantation receiving thrombolysis, PTA, and stent placement in our institute from November 2003 to April 2007 were retrospectively analyzed. Based on the prognosis of grafts, 21 patients were divided into poor-prognosis group and non-poor-prognosis group. Fifteen variables (including biliary complication, hepatic artery restenosis, early or late artery complication, and so on) were analyzed in both groups with binary logistic regression analysis to screen out the risk factors related to prognosis of pereutaneous interventional treatment for hepatic artery complications after OLT. Results: Twenty-one patients were followed for mean 436 days, median 464 days (3-1037 days). The poor-prognosis group included 11 patients (5 cases received retransplantation, and 6 died). The mean survival time of grafts in poor-prognosis group was 191 days, and median survival time was 73 days (3-616 days). The mean survival time of grafts in non-poor-prognosis group which included 10 patients was 706 days, and median survival time was 692 days (245-1037 days). Univariate analysis showed there were significant difference in biliary complication, total bilimbin and indirect bilirubin between the two groups. The binary, logistic regression analysis showed the risk factor related to prognosis was with biliary complication before the interventional management (P=0.027, OR=22.818). Conclusion: Biliary complication before interventional management is the risk factor related to poor prognosis of patients with hepatic artery stenosis or thrombosis receiving interventional treatment. (authors)

  6. Evaluation of Factors Influencing Liver Function Test in On-Pump Coronary Artery Bypass Graft Surgery

    Directory of Open Access Journals (Sweden)

    Shahrbano Shahbazi

    2013-12-01

    Full Text Available Background: Liver dysfunction during on-pump coronary artery bypass graft surgery (CABG is a rare complication but is associated with significant morbidity and mortality. The ability to identify high-risk patients may be helpful in planning appropriate management strategies. We aimed to evaluate the factors influencing liver function tests during on-pump CABG. Methods: In 146 patients scheduled for on-pump CABG, the liver function test was done preoperatively and on the first postoperative day. Some preoperative and intraoperative risk factors were checked and then the postoperative liver function tests were compared with the preoperative ones. Probable relationships between these changes and the preoperative and intraoperative risk factors were studied. Results: A medical history of diabetes had a significant relationship with the changes in direct bilirubin. Preoperative central venous pressure had a significant relationship with the changes in aspartate aminotransferase and alanine aminotransferase. Use of intra-aortic balloon pump and duration of aortic cross-clamp were significantly related to the changes in the liver function tests except for alanine aminotransferase and alkaline phosphatase. Conclusion: It seems that the techniques for the reduction of cardiopulmonary bypass and aortic cross-clamp duration may be useful to protect liver function. We recommend that a larger population of patients be studied to confirm these findings.

  7. Evaluation of arterial diseases by intravenous digital angiography (IVSDA) and risk factors in patients with cerebrovascular disease

    International Nuclear Information System (INIS)

    Intravenous digital angiography (IVSDA) has been performed in 1,031 consecutive patients during the previous 4 years. Complications of IVSDA, such as coughing, dermal reaction, nausea and vomiting, occurred in 77 patients (7.5%). Among them, 234 patients with a definite diagnosis of cerebrovascular disease were entered onto this study. On the basis of findings of IVSDA, the patients were largely classified into six groups: internal carotid artery (ICA) occlusion, ICA stenosis, middle cerebral artery (MCA) occlusion, MCA stenosis, marked arterial elongation, and normal findings. A group of the patients with ICA occlusion was characterized by having sudden onset with less complicated hypertension. In this group, etiological factors seemed to be embolism, intra-atheromatic hemorrhage, and dissecting aneurysm, as well as atherosclerosis. Major risk factors were hypertension, smoking, diabetes mellitus, and ischemic heart disease for lesions of the main trunk; and severe hypertension, high hematocrit levels and elevated platelet aggregability for lesions of perforating and small cortical arteries and arterioles. In the case of arterial elongation, platelet aggregability elicited by ADP was not suppressed by antiplatelet agents. These patients need to receive intensive treatment to prevent relapse of the disease. (Namekawa, K)

  8. Evaluation of arterial diseases by intravenous digital angiography (IVSDA) and risk factors in patients with cerebrovascular disease

    Energy Technology Data Exchange (ETDEWEB)

    Fukui, Toshiya (Kakeyu Hospital, Nagano (Japan))

    1989-04-01

    Intravenous digital angiography (IVSDA) has been performed in 1,031 consecutive patients during the previous 4 years. Complications of IVSDA, such as coughing, dermal reaction, nausea and vomiting, occurred in 77 patients (7.5%). Among them, 234 patients with a definite diagnosis of cerebrovascular disease were entered onto this study. On the basis of findings of IVSDA, the patients were largely classified into six groups: internal carotid artery (ICA) occlusion, ICA stenosis, middle cerebral artery (MCA) occlusion, MCA stenosis, marked arterial elongation, and normal findings. A group of the patients with ICA occlusion was characterized by having sudden onset with less complicated hypertension. In this group, etiological factors seemed to be embolism, intra-atheromatic hemorrhage, and dissecting aneurysm, as well as atherosclerosis. Major risk factors were hypertension, smoking, diabetes mellitus, and ischemic heart disease for lesions of the main trunk; and severe hypertension, high hematocrit levels and elevated platelet aggregability for lesions of perforating and small cortical arteries and arterioles. In the case of arterial elongation, platelet aggregability elicited by ADP was not suppressed by antiplatelet agents. These patients need to receive intensive treatment to prevent relapse of the disease. (Namekawa, K).

  9. La diversificación en el medio rural como factor de desarrollo

    Directory of Open Access Journals (Sweden)

    Mercedes Millán Escriche

    2002-01-01

    Full Text Available La diversificación de las rentas agrarias está considerada como una de las vías fundamentales para conseguir el desarrollo de numerosos espacios rurales europeos y, de modo muy particular, de aquellos que por su especial situación de declive precisan un motor de reactivación más allá de las actividades tradicionales del medio. Entre la gama de posibilidades, dado el fracaso de las inversiones exógenas, el turismo es uno de los instrumentos a los que se otorga mayor eficacia porque puede aglutinar las sinergias locales. Así se constata al revisar distintos documentos procedentes de instancias europeas, en los que aparece una apuesta clara por esta actividad, gracias a la transversalidad de sus beneficios hacia otros sectores de la economía, hacia las infraestructuras y, lo que es realmente importante para la población de estos espacios, hacia el empleo. El auténtico reto, para quienes tienen en sus manos la elaboración y posterior comercialización de los diferentes productos que se engloban bajo el «paraguas» Turismo Rural, consiste en otorgarles una imagen cuya seña de identidad sea la Calidad. Calidad que debe encontrarse en las infraestructuras de acogida, en quienes prestan el servicio y, cómo no, en el propio espacio de implantación, porque de no ser así la sostenibilidad del producto y, lo que puede ser más grave, del medio, acabarían destruyéndose.

  10. Molecular mechanisms of hypoxia-inducible factor-induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension.

    Science.gov (United States)

    Veith, Christine; Schermuly, Ralph T; Brandes, Ralf P; Weissmann, Norbert

    2016-03-01

    Oxygen (O2) is essential for the viability and function of most metazoan organisms and thus is closely monitored at both the organismal and the cellular levels. However, alveoli often encounter decreased O2 levels (hypoxia), leading to activation of physiological or pathophysiological responses in the pulmonary arteries. Such changes are achieved by activation of transcription factors. The hypoxia-inducible factors (HIFs) are the most prominent hypoxia-regulated transcription factors in this regard. HIFs bind to hypoxia-response elements (HREs) in the promoter region of target genes, whose expression and translation allows the organism, amongst other factors, to cope with decreased environmental O2 partial pressure (pO2). However, prolonged HIF activation can contribute to major structural alterations, especially in the lung, resulting in the development of pulmonary hypertension (PH). PH is characterized by a rise in pulmonary arterial pressure associated with pulmonary arterial remodelling, concomitant with a reduced intravascular lumen area. Patients with PH develop right heart hypertrophy and eventually die from right heart failure. Thus, understanding the molecular mechanisms of HIF regulation in PH is critical for the identification of novel therapeutic strategies. This review addresses the relationship of hypoxia and the HIF system with pulmonary arterial dysfunction in PH. We particularly focus on the cellular and molecular mechanisms underlying the HIF-driven pathophysiological processes. PMID:26228924

  11. Impact of Personal Characteristics and Technical Factors on Quantification of Sodium 18F-Fluoride Uptake in Human Arteries

    DEFF Research Database (Denmark)

    Blomberg, Björn Alexander; Thomassen, Anders; de Jong, Pim A; Simonsen, Jane; Lam, Marnix; Nielsen, Anne; Mickley, Hans; Mali, Willem; Alavi, Abass; Høilund-Carlsen, Poul Flemming

    2015-01-01

    Sodium (18)F-fluoride ((18)F-NaF) PET/CT imaging is a promising imaging technique for assessment of atherosclerosis, but is hampered by a lack of validated quantification protocols. Both personal characteristics and technical factors can affect quantification of arterial (18)F-NaF uptake. This...

  12. Prevalence and risk factors of asymptomatic peripheral arterial disease in patients with COPD in Taiwan.

    Directory of Open Access Journals (Sweden)

    Ming-Shian Lin

    Full Text Available AIM: Chronic obstructive pulmonary disease (COPD is an independent risk factor for cardiovascular morbidity and mortality. The aim of this study was to determine the prevalence of asymptomatic peripheral arterial disease (PAD and the associated risk factors for patients with COPD. METHODS: This prospective cross-sectional study enrolled 427 COPD patients (mean age: 70.0 years without PAD symptoms consecutively. Demographic data, lung function and cardiovascular risk factors were recorded. The ankle-brachial index (ABI was used to detect PAD (ABI<0.90. RESULTS: The overall prevalence of asymptomatic PAD in the COPD patients was 8% (2.5% in the younger participants (<65 years of age, n = 118 and 10% in the elderly participants (≥65 years of age, n = 309. The COPD patients with asymptomatic PAD had a significantly higher rate of hyperlipidemia (47.1% vs. 10.4% and hypertension (79.4% vs. 45.8% than those without asymptomatic PAD (p<0.05. There was no significant difference in lung function (forced vital capacity and forced expiratory volume in one second between the two groups. In multivariate logistic regression, hyperlipidemia was the strongest independent factor for PAD (odds ratio (OR: 6.89, p<0.005, followed by old age (OR: 4.80, hypertension (OR: 3.39 and smoking burden (pack-years, OR: 1.02. CONCLUSIONS: The prevalence of asymptomatic PAD among COPD patients in Taiwan is lower than in Western countries. Hyperlipidemia, old age, hypertension, and smoking burden were the associated cardiovascular risk factors. However, there was no association between lung function and PAD in the COPD patients.

  13. RESTRICCIÓN DEL CRECIMIENTO INTRAUTERINO COMO FACTOR DE RIESGO PARA MALFORMACIONES CONGÉNITAS

    Directory of Open Access Journals (Sweden)

    Julio Nazer H

    2009-01-01

    Full Text Available Antecedentes: La restricción del crecimiento intrauterino (RCIU se estima que está presente en el 5% de los nacimientos y es la manifestación de procesos aberrantes que impiden el desarrollo normal del feto. Objetivos: Estimar la frecuencia de esta patología en la maternidad del Hospital Clínico de la Universidad de Chile. Obtener la tasa prevalencia al nacimiento de malformaciones congénitas (MFC y comparar la frecuencia en recién nacidos pequeños (PEG con los adecuados (AEG y grandes (GEG para la edad gestacional. Método: Se estudian todos los nacimientos, vivos y mortinatos, ocurridos entre enero de 1997 a diciembre de 2008, contenidos en la base de datos del ECLAMC (Estudio Colaborativo Latino Americano de Malformaciones Congénitas desde 1969 a la fecha. Se excluyen los recién nacidos con malformaciones como hidrocefalia, anencefalia e hidrops, que por sus características dificultan la posibilidad de clasificación en PEG, AEG o GEG. Resultados: 10,1% de los nacimientos del período eran PEG. Entre los nacidos vivos 10% fueron PEG, mientras que 33,5% de los mortinatos eran PEG (pBackground: Fetal growth restriction (FGR is the result of anomalies that prevent the normal development of the fetus, it is present in about the 5% of births. Objectives: To estímate the frequency of FGR in the Clini-cal Hospital of the University of Chile. To estímate the congenital malformation prevalence rate at birth and compare it among small (SGE, adequate (AGE and large (LGE newborns according their gestational age. Methods: All live births and stillbirths included in the ECLAMC (Estudio Colaborativo Latino Americano de Malformaciones Congénitas registered from January 1997 and December 2008 were considered. Newborns with congenital malformations that modified per se the size of the child, like hydrocephaly anencephaly and hydrops were excluded. Results: 10.1% of newborns were SGE. Among live births 10% were SGE instead of the 33.5% found in

  14. Pre-clinical atherosclerosis evaluated by carotid artery intima-media thickness and the risk factors in children

    Institute of Scientific and Technical Information of China (English)

    YANG Xiao-zheng; LIU Ying; MI Jie; TANG Chao-shu; DU Jun-bao

    2007-01-01

    Background Atherosclerosis as a cardiovascular disease was found to begin even in the fetal period. However,information about risk factors of pre-clinical atherosclerosis in childhood has been limited. Hence, this study was aimed to find out the risk factors of atherosclerosis by measuring the carotid artery intima-media thickness in children. High resolution B-mode ultrasound used to examine the carotid artery intima-media thickness was demonstrated to be useful in finding the early carotid structural changes.Methods The study included 79 children who were divided into two groups according to their ages: group Ⅰ consisted of 42 children with ages from 5 to 9 years and group Ⅱ consisted of 37 children with ages from 10 to 18 years, Among them,23 had a positive family history for risk, such as hypertension, obesity or dyslipidemia. Blood samples were collected and total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein were assayed. The carotid artery intima-media thickness was measured by ultrasound. Comparisons were done between the two groups using Student's t tests and Chi-square analysis. Body mass index, blood pressure, levels of lipids, family history and the carotid artery intima-media thickness were calculated by conditional logistic regression analysis.Results Compared with the children without a positive family history, the incidence of the increased carotid artery intima-media thickness was significantly high (x2=4.364, P<0.05). There were no statistically significant differences between left and right carotid arteries in carotid artery intima-media thickness (P>0.05). In this study, diastolic blood pressure and the atherosclerosis index were suggested to be the risk factors to the thickened carotid artery intima-media thickness. In group I the diastolic blood pressure's odds radio was 1.187 (P=0.035) and the atherosclerosis index odds radio was 37.165 (P=0.001); in group Ⅱ the diastolic blood pressure's odds

  15. Thimerosal blocks stimulated but not basal release of endothelium-derived relaxing factor (EDRF) in dog isolated coronary artery.

    OpenAIRE

    Crack, P.; Cocks, T.

    1992-01-01

    1. The effect of an acetly-coA lysolecithin acyltransferase inhibitor, thimerosal, on the release of endothelium-derived relaxing factor (EDRF) was examined in the greyhound isolated coronary artery. 2. Thimerosal (1-10 microM) relaxed fully, ring segments of coronary artery which were contracted with the thromboxane A2-mimetic, U46619 (30 nM). The response was endothelium-dependent, slow in both onset and time to reach maximum. The maximum relaxation to the highest concentration of thimerosa...

  16. Risk Factors and Clinical Evaluation of Superficial Femoral Artery Stent Fracture: Prote'ge'GPS Stent

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Da Un; Kim, Jae Kyu; Jung, Hye Doo; Huh, Tae Wook; Yim, Nam Yeol; Oh, Hyun jun; Choi, Soo Jin Na [Chonnam National University Hospital, Chonnam National University, Medical School, Gwangju (Korea, Republic of); Chang, Nam Kyu [Chonnam National University Hwasun Hospital, Chonnam National University, Medical School, Hwasun (Korea, Republic of)

    2010-12-15

    To evaluate the occurrence of superficial femoral artery stent fractures, the risk factors of stent fracture, and the relationship between fractures and clinical findings. Of the 38 patients who underwent treatment with Prote'ge'GPS stenting due to arterial occlusions on the superficial femoral artery, 17 also underwent a clinical analysis. Forty-three stents were inserted in the 17 superficial femoral arteries, ranging between 15 and 50 cm in length, with a mean treated length of 26.4 cm (15-50 cm). A fracture was evaluated by taking a PA and lateral simple radiography, as well as a follow-up evaluation accompanied with a CT angiography, DSA, and a color Doppler sonography. The examination involved the assessment of the difference between bone fractures due to length, placement, and frequency. Fractures occurred in 13 of 43 stents (30.2%). A total of 10 (71.4%) occurred in the upper third, compared to 4 (28.6%) in the lower third of the superficial femoral artery. In addition, 10 stents (71.4%) had a single strut fracture, whereas 4 (28.6%) had multiple strut fractures. A stent fracture occurred more frequently when the stents and lesions were longer (p=0.021, 0.012) and the stents were inserted near the joint. However, there was no significant relationship between stent numbers and the fractures (p=0.126). When the stents were inserted along the popliteal artery, a stent fracture occurred more frequently in the lower third of the artery. The stent fractures did not significantly influence the patency rate of the stented artery (p=0.44) Prote'ge'GPS stents in the superficial femoral artery revealed a considerable number of fractures and the fracture frequency showed a significant relationship with the length of stents and lesions. The closer stent insertion was to the joints, the more frequently fractures occurred. There were no evident significant relationships between the presence of stent fractures and the patency of the stented arteries

  17. Prevalence of and risk factors for aspirin resistance in elderly patients with coronary artery disease

    Institute of Scientific and Technical Information of China (English)

    Xian-Feng Liu; Jian Cao; Li Fan; Lin Liu; Jian Li; Guo-Liang Hu; Yi-Xin Hu; Xiao-Li Li

    2013-01-01

    Objective To assess the prevalence of and related risk factors for aspirin resistance in elderly patients with coronary artery disease (CAD). Methods Two hundred and forty-six elderly patients (75.9 ± 7.4 years) with CAD who received daily aspirin therapy (≥ 75 mg) over one month were recruited. The effect of aspirin was assessed using light transmission aggregometry (LTA) and thrombelastography platelet mapping assay (TEG). Aspirin resistance was defined as ≥ 20% arachidonic acid (AA)-induced aggregation and ≥ 70% adenosine diphosphate (ADP)-induced aggregation in the LTA assay. An aspirin semi-responder was defined as meeting one (but not both) of the criteria described above. Based on the results of TEG, aspirin resistance was defined as ≥ 50% aggregation induced by AA. Results As determined by LTA, 23 (9.3%) of the elderly CAD patients were resistant to aspirin therapy; 91 (37.0%) were semi-responders. As determined by TEG, 61 patients (24.8%) were aspirin resistant. Of the 61 patients who were aspirin resistant by TEG, 19 were aspirin resistant according to LTA results. Twenty-four of 91 semi-responders by LTA were aspirin resistant by TEG. Multivariate logistic risk factor for aspirin resistance as determined by TEG. Conclusions A significant number of elderly patients with CAD are resistant to aspirin therapy. Fasting blood glucose level is closely associated with aspirin resistance in elderly CAD patients.

  18. Granulocyte colony-stimulating factor ameliorates coronary artery elastin breakdown in a mouse model of Kawasaki disease

    Institute of Scientific and Technical Information of China (English)

    Liu Junfeng; Chen Zhi; Du Zhongdong; Lu Dunxiang

    2014-01-01

    Background Coronary artery damage from Kawasaki disease (KD) is closely linked to the dysfunction of the endothelial progenitor cells (EPCs).The aim of the present study was to evaluate the modulatory effect of granulocyte colony stimulating factor (G-CSF) on EPCs and elastin breakdown of coronary arteries in a KD mouse model.Methods A Lactobacillus casei cell wall extract (LCWE)-induced KD model was established in C57BL/6 mice that were subsequently administrated with recombinant human G-CSF (rhG-CSF).Nω-nitro-L-arginine methyl ester (L-NAME) was administrated for the negative intervention.Evaluations included coronary artery lesions,EPC number and functions,and the plasma concentration of nitric oxide (NO).Results Elastin breakdown was found in the coronary arteries of model mice 56 days after injection of LCWE.The number of circulating EPCs,plasma concentration of NO,and functions of bone marrow EPCs,including proliferation,adhesion,and migration abilities,were all lower in the KD model group compared with those in the control group.After administration of rhG-CSF,the number of circulating EPCs and plasma concentration of NO were increased significantly compared with those in the KD model group.There were also increases in the functional indexes of EPCs.Furthermore,rhG-CSF administration improved the elastin breakdown effectively.However,these protective effects of rhG-CSF on coronary arteries were attenuated by L-NAME.Conclusion The present study indicated that the administration of G-CSF prevents elastin breakdown of the coronary arteries by enhancing the number and functions of EPCs via the NO system,and then accelerates the repair of coronary artery lesions in the KD.

  19. Risk Factors and Markers for Acute Myocardial Infarction With Angiographically Normal Coronary Arteries.

    Science.gov (United States)

    Daniel, Maria; Ekenbäck, Christina; Agewall, Stefan; Brolin, Elin B; Caidahl, Kenneth; Cederlund, Kerstin; Collste, Olov; Eurenius, Lars; Frick, Mats; Younis-Hassan, Shams; Henareh, Loghman; Jernberg, Tomas; Malmqvist, Karin; Spaak, Jonas; Sörensson, Peder; Hofman-Bang, Claes; Tornvall, Per

    2015-09-15

    Myocardial Infarction with normal coronary arteries (MINCA) is common with a prevalence of 1% to 12% of all myocardial infarctions. The pathogenic mechanisms of MINCA are still unknown, but endothelial dysfunction has been suggested as a possible cause. To investigate risk factors and markers for MINCA, we conducted a case-control study. Considering the reported low prevalence of classical risk factors for coronary heart disease (CHD) in some but not all studies, our hypothesis was that endothelial function and intima-media thickness (IMT) were better, respectively lower, than CHD controls. One hundred patients with MINCA fulfilling diagnostic criteria according to the European Society of Cardiology/American Collage of Cardiology/American Heart Association universal definition of myocardial infarction with myocarditis excluded by cardiac magnetic resonance imaging were investigated. Risk factors, endothelial function (EndoPAT), and IMT were compared to gender- and age-matched patients with myocardial infarction and CHD, respectively healthy controls. Smoking, hypertension, impaired glucose tolerance and diabetes mellitus, inflammatory disease, and psychiatric disorders were more common in patients with MINCA than in healthy controls. In contrast to patients with CHD, the lipid profile was antiatherogenic with low low-density lipoprotein and high high-density lipoprotein cholesterol. There were no major differences between the groups regarding endothelial function and IMT that were in the normal range. In conclusion, the present study showed that MINCA was associated with many established cardiovascular risk factors without major differences in atherosclerosis markers. MINCA patients recalled a high prevalence of emotional stress before admission that together with previous psychiatric vulnerability and female gender speaks strongly in favor of Takotsubo syndrome being an important cause of MINCA. PMID:26251000

  20. Risk factors for peripheral arterial disease among patients with chronic kidney disease.

    Science.gov (United States)

    Chen, Jing; Mohler, Emile R; Xie, Dawei; Shlipak, Michael G; Townsend, Raymond R; Appel, Lawrence J; Raj, Dominic S; Ojo, Akinlolu O; Schreiber, Martin J; Strauss, Louise F; Zhang, Xiaoming; Wang, Xin; He, Jiang; Hamm, L Lee

    2012-07-01

    Patients with chronic kidney disease (CKD) have an increased risk for developing peripheral arterial disease (PAD). The aim of this study was to examine the cross-sectional association between novel risk factors and prevalent PAD in patients with CKD. A total of 3,758 patients with estimated glomerular filtration rates of 20 to 70 ml/min/1.73 m(2) who participated in the Chronic Renal Insufficiency Cohort (CRIC) study were included in the present analysis. PAD was defined as an ankle-brachial index arm or leg revascularization. After adjustment for age, gender, race, cigarette smoking, physical activity, history of hypertension and diabetes, pulse pressure, high-density lipoprotein cholesterol, estimated glomerular filtration rate, and CRIC clinical sites, several novel risk factors were significantly associated with PAD. For example, odds ratios for a 1-SD higher level of risk factors were 1.18 (95% confidence interval [CI] 1.08 to 1.29) for log-transformed high-sensitivity C-reactive protein, 1.18 (95% CI 1.08 to 1.29) for white blood cell count, 1.15 (95% CI 1.05 to 1.25) for fibrinogen, 1.13 (95% CI 1.03 to 1.24) for uric acid, 1.14 (95% CI 1.02 to 1.26) for glycosylated hemoglobin, 1.11 (95% CI 1.00 to 1.23) for log-transformed homeostasis model assessment of insulin resistance, and 1.35 (95% CI 1.18 to 1.55) for cystatin C. In conclusion, these data indicate that inflammation, prothrombotic state, oxidative stress, insulin resistance, and cystatin C were associated with an increased prevalence of PAD in patients with CKD. Further studies are warranted to examine the causal effect of these risk factors on PAD in patients with CKD. PMID:22465315

  1. A simultaneous test of the relationship between identified psychosocial risk factors and recurrent events in coronary artery disease patients

    OpenAIRE

    Grewal, Keerat; Gravely-Witte, Shannon; Stewart, Donna E.; Grace, Sherry L.

    2011-01-01

    Psychosocial factors are increasingly recognized as risk indicators for coronary artery disease (CAD) prognosis, and they are likely interrelated. The objective of this study is to simultaneously test the relationship between key psychosocial constructs as independent factor scores, and recurrent events in CAD patients. One thousand two hundred and sixty eight CAD outpatients of 97 cardiologists were surveyed at two points. Recurrent events or hospitalization in the intervening 9 months were ...

  2. Circunferência da cintura e índice de massa corporal como preditores da hipertensão arterial Waist circumference and body mass index as predictors of hypertension

    Directory of Open Access Journals (Sweden)

    Maria do Rosário Gondim Peixoto

    2006-10-01

    Full Text Available OBJETIVO: Avaliar a associação entre índices antropométricos, índice de massa corporal (IMC e circunferência da cintura (CC e hipertensão arterial (HA e avaliar a capacidade desses índices na predição da HA. MÉTODOS: Estudo transversal populacional realizado em Goiânia (GO, em 2001, com amostra de 1.238 adultos, de vinte a 64 anos. Foi definida como obesidade total (IMC > 30 kg/m², como obesidade abdominal (CC no nível 2 - CC > 88 cm para mulheres e > 102 cm para homens e como HA (pressão sistólica > 140 mmHg ou pressão diastólica > 90 mmHg, ou uso de hipotensores. Foi realizada análise de regressão logística múltipla para avaliar as associações entre os índices antropométricos e a HA. Análise de curva ROC para avaliar a sensibilidade e especificidade do IMC (> 30 e nível 2 da CC na predição da HA e para determinar os pontos de corte com melhor predição da HA. RESULTADOS: A CC apresentou associação com a HA em ambos os sexos. O nível 2 da CC e o IMC >30 kg/m² apresentaram baixa sensibilidade em identificar a HA. Os pontos de corte com melhor capacidade preditiva de HA coincidiram com o nível 1 da CC (> 80 cm e com o IMC >25 kg/m² (sobrepeso, para as mulheres, e foram inferiores aos valores do nível 1 da CC e de sobrepeso, para os homens. CONCLUSÃO: O nível 2 da CC e o IMC > 30 kg/m² não são adequados para identificar os grupos de maior risco de HA, já que esse risco se eleva com pequenos aumentos na adiposidade.OBJECTIVE: To evaluate the association between anthropometric indexes - body mass index (BMI and waist circumference (WC - and hypertension, and to evaluate the predictive value of these indexes in detecting hypertension. METHODS: Cross-sectional population study conducted in the city of Goiânia (GO with a sample of 1,238 adults aged twenty to 64 years, in 2001. Total obesity was defined as BMI > 30 kg/m²; abdominal obesity was defined as level 2 WC > 88 cm for women and > 102 cm for men, and

  3. El cacahuate (Arachis hypogaea L.); como factor de desarrollo rural regional

    OpenAIRE

    Calixto Escobar, Elizabeth

    2012-01-01

    Esta investigación, se realizó en los Municipios de Ahuatlan, Tlapanala y Huaquechula, Puebla, México, con el objetivo de determinar los factores de una estrategia de desarrollo rural, orientado a los productores regionales de cacahuate (Arachis hypogaea L.), que fomente la incorporación de valor agregado al cultivo del cacahuate mediante su industrialización y comercialización. La metodología usada se desarrollo en dos fases; primera fase “Diagnóstico”: consistió en la recolección de la...

  4. El fibrinógeno como factor de riesgo de enfermedad aterotrombótica

    OpenAIRE

    Julio César Fernández Travieso

    2009-01-01

    La disfunción endotelial y la inflamación representan un decisivo papel desde las etapas tempranas de la aterosclerosis hasta la aparición de los síndromes coronarios agudos, en los cuales el fibrinógeno ha demostrado tener una activa participación. Además, en concentraciones elevadas se relaciona con la trombosis y ha sido demostrado que es un factor independiente de riesgo cardiovascular. Hoy día, concentraciones elevadas de fibrinógeno junto con la proteína C-reactiva, la lipoproteína (a) ...

  5. Turismo rural como estrategia de diversificación: factores determinantes y resultados en Galicia

    OpenAIRE

    Diéguez-Castrillón, M.ª Isabel; Gueimonde-Canto, Ana; ANA I. SINDE-CANTORNA

    2009-01-01

    [ES] Los determinantes y los resultados de la estrategia de diversificación se han abordado frecuentemente en la literatura. Son sin embargo pocos los estudios que analizan la diversificación en sectores concretos donde el impulso para diversificar no es estrictamente económico, sino político o social. La diversificación de la actividad agrícola hacia el turismo en Galicia es un claro ejemplo de este fenómeno. El objetivo de este trabajo es determinar cuales son los factores que motivan a tit...

  6. Las variables emocionales como factores de riesgo de los trastornos de la conducta alimentaria

    OpenAIRE

    Aitziber Pascual; Itziar Etxebarria; Enrique Echeburúa

    2011-01-01

    Este estudio ex post facto analizó si determinadas variables emocionales pueden considerarse factores de riesgo de los trastornos de la conducta alimentaria (TCA). Se analizaron las siguientes variables: ansiedad-rasgo, dificultad para identificar y expresar las emociones (alexitimia), autoestima, actitud negativa hacia la expresión emocional, percepción negativa de las emociones, influuencia de la alimentación, el peso y la figura corporal en el estado de ánimo, necesidad de control y estrat...

  7. The Effect of PAI-1 4G/5G Polymorphism and Clinical Factors on Coronary Artery Occlusion in Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Tajinder Kumar Parpugga

    2015-01-01

    Full Text Available Objective. Data on the impact of PAI-1-675 4G/5G genotype for fibrinolysis during myocardial infarction are inconsistent. The aim of our study was to evaluate the association of clinical and genetic (PAI-1-675 4G/5G polymorphism factors with coronary artery occlusion in patients with myocardial infarction. Materials and Methods. PAI-1-675 4G/5G detection was achieved by using Sanger sequencing in a sample of patients hospitalized for stent implantation due to myocardial infarction. We categorized the patients into two groups: patients with coronary artery occlusion and patients without coronary artery occlusion according to angiographic evaluation. Results. We identified n=122 (32.4% 4G/4G, n=186 (49.5% 4G/5G, and n=68 (18.1% 5G/5G PAI-1 genotype carriers. Univariate and multivariate analysis showed that only the 4G/5G genotype was associated with coronary artery occlusion (OR: 1.656 and 95% CI: 1.009–2.718, p=0.046. Conclusions. Our results showed that carriers of PAI-1 4G/5G genotype with myocardial infarction have increased odds of coronary artery occlusion more than 1.6 times in comparison to the carriers of homozygous genotypes.

  8. Expression and role of factor inhibiting hypoxia-inducible factor-1 in pulmonary arteries of rat with hypoxia-induced hypertension

    Institute of Scientific and Technical Information of China (English)

    Daiyan Fu; Aiguo Dai; Ruicheng Hu; Yunrong Chen; Liming Zhu

    2008-01-01

    Hypoxia-inducible factor-11α subunit (HIF-1α) plays a pivotal role during the development of hypoxia-induced pulmonary hypertension (HPH) by transactivating it's target genes. As an oxygen-sensitive attenuator, factor inhibiting HIF-1 (FIH)hydroxylates a conserved asparagine residue within the C-terminal transactivation domain of HIF-1α under normoxia and moderate hypoxia. FIH protein is downregulated in response to hypoxia, but its dynamic expression and role during the development of HPH remains unclear. In this study,an HPH rat model was established. The mean pulmonary arterial pressure increased significantly after 7 d of hypoxia.The pulmonary artery remodeling index became evident after 7 d of hypoxia, while the right ventricular hypertrophy index became significant after 14 d of hypoxia. The messenger RNA (mRNA) and protein expression of HIF-1α and vascular endothelial growth factor (VEGF), a well-characterized target gene of HIF-1α, were markedly upregulated after exposure to hypoxia in pulmonary arteries. FIH protein in lung tissues declined after 7 d of hypoxia and continued to decline through the duration of hypoxia. FIH mRNA had few changes after exposure to hypoxia compared with after exposure to normoxia.In hypoxic rats, FIH protein showed significant negative correlation with VEGF mRNA and VEGF protein. FIH protein was negatively correlated with mean pulmonary arterial pressure, pulmonary artery remodeling index and right ventricular hypertrophy index. Taken together, our results suggest that, in the pulmonary arteries of rat exposed to moderate hypoxia, a time-dependent decrease in FIH protein may contribute to the development of rat HPH by enhancing the transactivation of HIF-1α target genes such as VEGF.

  9. La energía como factor fundamental en el proceso económico

    OpenAIRE

    Melo Poveda, Yormy Eliana

    2013-01-01

    Resumen: Desde la prehistoria, la energía en sus diferentes formas ha estado fuertemente vinculada al desarrollo y evolución de la vida del hombre. De ahí que sea relevante realizar una mirada histórica sobre el papel que estos han desempeñado, con el fin de resaltar dicha relación y el impacto del uso de las diferentes fuentes de energía en los procesos económicos que se llevan a cabo. La hipótesis que se asume es que la energía es un factor que explica el proceso de crecimiento económic...

  10. La agresividad en la infancia: el estilo de crianza parental como factor relacionado

    OpenAIRE

    Raya Trenas, Antonio Félix; Pino Osuna, M. José; Herruzo Cabrera, Javier

    2009-01-01

    El presente estudio se propone analizar la posible relación existente entre la agresividad en los niños medida por sus padres a través del BASC (Sistema de Evaluación de la Conducta de Niños y Adolescentes) y el estilo de crianza según el PCRI (Cuestionario de Crianza Parental) compuesto por siete factores: apoyo, satisfacción con la crianza, compromiso, comunicación, disciplina, autonomía y distribución de rol, en una muestra de 338 niños (182 niños y 156 niñas) entre 3 y 14 a...

  11. Evolución de la seguridad vial en medio urbano como disciplina y como factor del diseño tipológico de la calle

    OpenAIRE

    Espelt Lleonart, Pere; León-Salas Tirado, David

    2009-01-01

    Frente al enfoque convencional de la seguridad vial centrado en la accidentalidad y las medidas físicas puntuales propias de un modelo de carretera, emerge otro registro técnico y metodológico específicamente urbano que resulta del enfoque integral propio de la evolución de la acción local. Bajo ese enfoque algunos países han adoptado medidas urbanísticas extensivas de gestión y reordenación del espacio viario como solución estructural de la adaptación del comportamiento de todos los usuarios...

  12. El factor de crecimiento transformante beta como blanco terapéutico Transforming growth factor-beta as a therapeutic target

    OpenAIRE

    Francisco Javier Gálvez-Gastélum; Ana Soledad Sandoval-Rodríguez; Juan Armendáriz-Borunda

    2004-01-01

    El factor de crecimiento transformante beta (TGF-beta) es una familia de proteínas que incluye al TGF-beta, activinas y a la proteína morfogénica de hueso (BMP, por sus siglas en inglés), citocinas que son secretadas y se relacionan estructuralmente en diferentes especies de metazoarios. Los miembros de la familia del TGF-beta regulan diferentes funciones celulares como proliferación, apoptosis, diferenciación, migración, y tienen un papel clave en el desarrollo del organismo. El TGF-beta est...

  13. El desarrollo local y empresarial: La formación como factor básico para orientar al emprendedor

    Directory of Open Access Journals (Sweden)

    Juan Uribe Toril

    2013-09-01

    Full Text Available Objeto: El presente artículo es un recorrido que se inicia con el repaso de las principales teorías del desarrollo local para adentrarse en el emprendedor y en el fomento de la cultura emprendedora en ámbitos rurales como medio de impulso del progreso local. También, estudiaremos la influencia de factores personales del emprendedor (experiencia, situación,… en la constitución de empresas y cómo afecta el nivel formativo (en sentido amplio en el desarrollo económico y del espíritu emprendedor a través de variables latentes, que se traduce en creación de nuevas empresas.Diseño/metodología: La investigación parte de un análisis y recopilación de la literatura existente en desarrollo local para pasar a un estudio transversal mediante procedimiento de encuesta directa. Para el tratamiento de la información obtenida se ha utilizado el análisis de clases latentes.Resultados: Del análisis de los datos se desprenden dos conclusiones principales: que la formación de partida y continua, la situación personal y el propio entorno, se configuran de una manera directa en el espíritu emprendedor y que programas de desarrollo permiten realizar diseños con garantías de éxito. De estas conclusiones emanan cinco reflexiones.Limitaciones: Encontramos una delimitación geográfica al haber sido entrevistadas empresas de la comunidad andaluza, aunque presumimos que, al centrarnos en localidades de baja densidad de población, son perfectamente extrapolables a otras zonas.Implicaciones prácticas: El estudio es de utilidad a los agentes sociales encargados del diseño de programas de capacitación empresarial y de la organización y control de herramientas potenciadoras de cultura emprendedora en entornos rurales.Implicaciones sociales: Fomento de empresas en entornos rurales que permiten disminuir la despoblación de los pueblos y mitigar la concentración humana en grandes urbes. Asimismo, a través del crecimiento económico de estos

  14. Plasma Tissue Factor Pathway Inhibitor Levels in Angiographically Defined Coronary Artery Disease Among Saudis

    Directory of Open Access Journals (Sweden)

    Syed Shahid Habib

    2013-05-01

    Full Text Available Objectives: This study was aimed to determine plasma levels of total (TFPI-T and free (TFPI-F tissue factor pathway inhibitor, plasminogen activator inhibitor-1 (PAI-1, and tissue plasminogen activator (t-PA in a cohort of Saudi patients with chronic stable angiographically defined coronary artery disease (CAD and to determine its correlation with its severity.Methods: This cross sectional study was conducted in the department of physiology and department of cardiology, College of Medicine, and King Khalid University Hospital and King Saud University, Riyadh. Sixty known cases of CAD who had undergone angiography (35 males and 25 females were selected. A control group included 39 (20 males and 19 females healthy subjects. Fasting venous blood samples were analyzed for total (TFPI-T and free (TFPI-F tissue factor pathway inhibitor, plasminogen activator inhibitor-1 (PAI-1, and tissue plasminogen activator (t-PA. Gensini scores and vessel scores were determined for assessing CAD severity.Results: There were non-significant differences between age, body mass index (BMI and Blood pressure between the controls and CAD subjects. A comparison of hemostatic markers between control and CAD patients showed significantly higher levels of Fibrinogen, PAI-1, TFPI-T and TFPI-F in CAD patients compared to control subjects. But there was no difference in plasma t-PA levels. TFPI-T had a significant positive correlation with severity of disease determined by Gensini Scores (r=0.344; p=0.006 and vessel scores (r=0.338; p=0.015.Conclusion: Plasma levels of total tissue factor pathway inhibitor are significantly related with the presence and severity of CAD. Elevated levels of TFPI-T may be considered as useful diagnostic and prognostic markers in patients with CAD.

  15. Risk factors for neurological worsening and symptomatic watershed infarction in internal carotid artery aneurysm treated by extracranial-intracranial bypass using radial artery graft.

    Science.gov (United States)

    Matsukawa, Hidetoshi; Tanikawa, Rokuya; Kamiyama, Hiroyasu; Tsuboi, Toshiyuki; Noda, Kosumo; Ota, Nakao; Miyata, Shiro; Oda, Jumpei; Takeda, Rihee; Tokuda, Sadahisa; Kamada, Kyousuke

    2016-08-01

    OBJECT The revascularization technique, including bypass created using the external carotid artery (ECA), radial artery (RA), and M2 portion of middle cerebral artery (MCA), has remained indispensable for treatment of complex aneurysms. To date, it remains unknown whether diameters of the RA, superficial temporal artery (STA), and C2 portion of the internal carotid artery (ICA) and intraoperative MCA blood pressure have influences on the outcome and the symptomatic watershed infarction (WI). The aim of the present study was to evaluate the factors for the symptomatic WI and neurological worsening in patients treated by ECA-RA-M2 bypass for complex ICA aneurysm with therapeutic ICA occlusion. METHODS The authors measured the sizes of vessels (RA, C2, M2, and STA) and intraoperative MCA blood pressure (initial, after ICA occlusion, and after releasing the RA graft bypass) in 37 patients. Symptomatic WI was defined as presence of the following: postoperative new neurological deficits, WI on postoperative diffusion-weighted imaging, and ipsilateral cerebral blood flow reduction on SPECT. Neurological worsening was defined as the increase in 1 or more modified Rankin Scale scores. First, the authors performed receiver operating characteristic curve analysis for continuous variables and the binary end point of the symptomatic WI. The clinical, radiological, and physiological characteristics of patients with and without the symptomatic WI were compared using the log-rank test. Then, the authors compared the variables between patients with and without neurological worsening at discharge and at the 12-month follow-up examination or last hospital visit. RESULTS Symptomatic WI was observed in 2 (5.4%) patients. The mean MCA pressure after releasing the RA graft (< 55 mm Hg; p = 0.017), mean (MCA pressure after releasing the RA graft)/(initial MCA pressure) (< 0.70 mm Hg; p = 0.032), and mean cross-sectional area ratio ([RA/C2 diameter](2) < 0.40 mm [p < 0.0001] and [STA/C2

  16. Renal Dysfunction after Off-Pump Coronary Artery Bypass Surgery- Risk Factors and Preventive Strategies

    Directory of Open Access Journals (Sweden)

    Gaurab Maitra

    2009-01-01

    Full Text Available Postoperative renal dysfunction is a relatively common and one of the serious complications of cardiac surgery. Though off-pump coronary artery bypass surgery technique avoids cardiopulmonary bypass circuit induced adverse effects on renal function, multiple other factors cause postoperative renal dysfunction in these groups of patients. Acute kidney injury is generally defined as an abrupt and sustained decrease in kidney function. There is no consen-sus on the amount of dysfunction that defines acute kidney injury, with more than 30 definitions in use in the literature today. Although serum creatinine is widely used as a marker for changes in glomerular filtration rate, the criteria used to define renal dysfunction and acute renal failure is highly variable. The variety of definitions used in clinical studies may be partly responsible for the large variations in the reported incidence. Indeed, the lack of a uniform definition for acute kidney injury is believed to be a major impediment to research in the field. To establish a uniform definition for acute kidney injury, the Acute Dialysis Quality Initiative formulated the Risk, Injury, Failure, Loss, and End-stage Kidney (RIFLE classification. RIFLE , defines three grades of increasing severity of acute kidney injury -risk (class R, injury (class I and failure (class F - and two outcome classes (loss and end-stage kidney disease. Various perioperative risk factors for postoperative renal dysfunction and failure have been identified. Among the important preoperative factors are advanced age, reduced left ventricular function, emergency surgery, preoperative use of intraaortic balloon pump, elevated preoperative serum glucose and creatinine. Most important intraoperative risk factor is the intraoperative haemodynamic instability and all the causes of postoperative low output syndrome com-prise the postoperative risk factors. The most important preventive strategies are the identification of the

  17. Fatores de risco cardiovasculares em adultos jovens com hipertensão arterial e/ou diabetes mellitus Factores de riesgo cardiovascular en adultos jóvenes con hipertensión y/o diabetes mellitus Cardiovascular risk factors in young adults with arterial hypertension and/or diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Thereza Maria Magalhães Moreira

    2010-12-01

    los eventos posibles, que requieren inversión en la prevención, así como en la formación y mantenimiento del sistema HIPERDIA.In this study we aimed to investigate the risk factors associated with arterial hypertension and diabetes mellitus in young adults assisted in six Family Health Units (UBASF, of Fortaleza, Ceará, Brazil. This is a descriptive and documental study, developed based on the records of the Care Program to Arterial Hypertension and Diabetes Mellitus (HIPERDIA. The sample was composed of 60 records, including hypertensive, diabetics and patients with the two diagnoses. The results showed prevalence of young female adults (78%. Regarding the risk factors, arterial hypertension (n=45, family history (n=33, overweight (n=33 and sedentary lifestyle (n=27 stood out. Regarding the cardiovascular risk stratification, most presented Medium additional risk for cardiovascular disease. We concluded that the individualized evaluation of risk factors supports an action addressed for possible events, being necessary investments in prevention and also in training and maintenance of the HIPERDIA system.

  18. Neoplasia de próstata, la dieta como factor de riesgo y prevención

    OpenAIRE

    López López, Luis Mariano

    2013-01-01

    Los estudios epidemiológicos muestran cómo la incidencia del cáncer de próstata ha aumentado a lo largo de los años, siendo el cáncer masculino más común y la segunda causa principal de muerte por cáncer entre los hombres en occidente. La epidemiología descriptiva del cáncer de próstata sugiere que se trata de una enfermedad prevenible si se reducen diferentes factores de riesgo como las dietas insanas. Esta prevención tiene la ventaja teórica de no sólo salvar vidas, sino también reducir la ...

  19. EL VIDEOBLOG COMO HERRAMIENTA CLAVE PARA UN APRENDIZAJE DE LENGUAS BASADO EN EL RESPETO AL FACTOR AFECTIVO.

    Directory of Open Access Journals (Sweden)

    Urtza Garay Ruiz

    2013-01-01

    Full Text Available En este artículo presentamos una investigación realizada con el objetivo de analizar los resultados de una intervención educativa donde el alumnado inmigrante utiliza vlogs para desarrollar un aprendizaje de segundas lenguas basado en el respeto al factor afectivo. Las técnicas de recogida y gestión de datos utilizadas fueron tanto cuantitativas como cualitativas. El resultado más relevante es que los vlogs son instrumentos válidos para el desarrollo de las habilidades lingüístico-afectivas del alumnado inmigrante, ya que posibilitan utilizar todas las lenguas del centro de enseñanza de forma simultánea y sencilla.

  20. The Analysis of Efficacy and Failure Factors of Uterine Artery Methotrexate Infusion and Embolization in Treatment of Cesarean Scar Pregnancy

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    Xiao An

    2013-01-01

    Full Text Available Objectives. This study observes therapeutic efficacy of uterine artery embolization combined with MTX infusion which terminates cesarean scar pregnancy (CSP and induces three factors which probably relate to failure. Methods. Twenty-three CSP patients were treated with combined uterine artery MTX infusion and embolization. Among them six patients with severe hemorrhage were immediately treated with interventional operation. Clinical effects were estimated by symptoms, serum -hCG, ultrasound, and MR. Results. Interventional treatments were technologically successful in 22 patients except one. Immediate hemostasis was achieved in all 6 patients with massive colporrhagia. No occurrence of infection and uterine necrosis was observed, but 12 women suffered abdominal pains. Nineteen patients’ uteri were preserved, whereas four underwent hysterectomy eventually. Conclusions. Transcatheter arterial chemoembolization is effective to treat high-risk CSP in preference to hysterectomy. To achieve more successful outcomes, three factors should be highlighted: adequate MTX dosage, appropriate embolic material, and complete embolization of target arteries that supply blood to embryo in the scar.

  1. Los profesionales de secundaria, como factores de riesgo en el síndrome de Burnout / Secondary School Professionals: Burnout Syndrome’s Risk Factors

    Directory of Open Access Journals (Sweden)

    Giselle León León

    2011-06-01

    Full Text Available

    Recibido 21 de julio de 2010 • Aceptado 31 de agosto de 2010 • Corregido 03 de octubre de 2010

     

    Resumen. Este artículo aborda el síndrome de Bournout, entendido como un trastorno de la adaptación ante el estrés crónico laboral que logra desencadenar síntomas físicos y psicológicos, los cuales dañan significativamente la ejecución profesional de los individuos que prestan servicios, en este particular, el trabajo de los docentes de secundaria, los cuales se describen como vulnerables por atender a adolescentes, quienes requieren mayor comunicación, atención y guía por las característica propias de esa etapa. Además se describen algunos factores que pueden incidir en el docente, desde una perspectiva individual como por ejemplo estrés, rol, edad, estado civil, entre otros. Asímismo factores laborales tales como baja implicación, sobre carga, burocracia, ambiente, consecuencias sobre el individuo y sobre la institución y medidas para prevenirlo.

     

    Abstract. This paper discusses the Burnout syndrome, understood as an adaptation disorder due to chronic occupational stress, triggering both physical and psychological symptoms that significantly affect the professional performance of individuals who work in services.  Secondary school  teachers consider themselves as vulnerable to this syndrome, since they work with teenagers that demand better communication, attention and guidance due to the normal characteristics of the age.  It also describes some of the factors that may affect teachers, either from an individual perspective (stress, role, age and civil status, among others; or from a labor perspective (low involvement, work overload, bureaucracy, environment, individual and institutional consequences and preventive measures.

  2. COMPORTAMIENTO DE PRÓTESIS DENTALES REMOVIBLES COMO FACTOR CAUSAL DE ESTOMATITIS SUB-PROTÉSICA: REPORTE DE UN CASO

    Directory of Open Access Journals (Sweden)

    Martha Leonor Rebolledo Cobos

    2012-12-01

    Full Text Available La presencia de prótesis removibles en la cavidad bucal acompañada de condiciones como: deficiente adaptación y ajuste, poca higiene bucal, presencia de microorganismos, hábitos, vicios incluyendo factores sistémicos, corresponde un factor causal para la aparición de estomatitis sub-protésica (ESP. Esta entidad patológica se caracteriza por la presencia de lesiones inflamatorias eritematosas, asintomáticas, de mayor prevalencia en el maxilar y con predilección al sexo femenino. Su tratamiento se encamina a eliminar los factores causales, control microbiano, higienización y en dado caso, reemplazo de la prótesis por una nueva. A continuación se presenta un caso de una paciente femenina que acude a la clínica odontológica de la Fundación Universitaria San Martín, presentando deficiente adaptación protésica del maxilar, la cual no se observó en adecuadas condiciones; al mismo tiempo que se evidenciaron en la mucosa lesiones similares a ESP. Se instauró un tratamiento integral mejorando el estado de salud oral de la paciente.

  3. Prognosis of unprotected left main coronary artery stenting and the factors affecting the outcomes in Chinese

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Background The long term prognosis of unprotected left main coronary artery (LMCA) stenting is controversial This study was conducted to evaluate the immediate and long term outcomes of LMCA stenting in Chinese patients and to determine which factors affect the outcomes. Methods From May 1997 to March 2003,224 patients in 23 hospitals underwent elective unprotected LMCA stenting with bare metal stents. Their clinical records were analysed to ascertain immediate and long term outcomes of LMCA stenting as well as factors influencing the prognosis .Results Stents were implanted into LMCA successfully in 223 cases (99.6 %). One death (0.5%) and one case of non-Q wave nonfatal myocardial infarction (MI) occurred in hospital. The mean follow-up time was (15.6±12.3) months. Cardiac death developed in 10 cases (4.5%), noncardiac death in 2 cases (0.9%), nonfatal MI in 4 cases (1.8%), target lesion revascularization (TLR) of LMCA in 26 cases (11.7%) and TLR of nonLMCA in 37 cases (16.5%). Univariate analysis showed that cardiac death correlated with left ventricular ejection fraction (LVEF < 40%), female gender and LMCA combined with multivessel disease; that major adverse cardiac events (MACE) correlated with LVEF < 40%, bifurcation lesion and incomplete revascularization. Logistic regression analysis revealed that LVEF < 40% and female gender were independent predictors of cardiac death and MACE. Follow-up angiography was performed in 102 cases (45.7%). The restenosis rate was 31.4%. Conclusions Long-term outcomes of stenting for selected patients with unprotected LMCA stenosis is acceptable. It should be performed in inoperable or low risk patients with LVEF ≥ 40% and isolated LMCA disease or LMCA combined with multivessel diseases in whom complete revascularization can be obtained.

  4. Factors associated with gender difference in the intima-media thickness of the common carotid artery

    International Nuclear Information System (INIS)

    Aim: To investigate the gender differences associated with a thinner intima-media thickness (IMT) of the common carotid artery (CCA) in women. Materials and methods: In a sample of 218 consecutive healthy volunteers comprising 110 men and 108 women, the IMT of the CCA was measured using B-mode ultrasonography. Blood pressure, fasting blood sugar, body mass index (BMI), blood lipid profile, homocysteine, folic acid, uric acid, high sensitive C-reactive protein, and thiobarbituric acid reactive substances (TBARS) levels were measured and compared with each other in both genders. Results: The IMT of the CCA was significantly thinner in women than in men (p = 0.012). Blood pressure, fasting plasma glucose, BMI, low-density lipoprotein cholesterol, triglycerides, homocysteine, uric acid, and TBARS were significantly (p < 0.05) lower, folic acid and high-density lipoprotein cholesterol (HDL-C) were significantly (p < 0.0001) higher in women compared with men. Multivariable logistic regression analysis revealed that higher serum levels of homocysteine, uric acid, and TBARS, and lower serum levels of HDL-C were significantly (p < 0.05) associated with male sex. Multiple linear regression analysis further revealed that age, sex, and BMI were independently associated with CCA IMT. Conclusions: The IMT of the CCA was thinner in women than in men. Traditional vascular risk factors explain only a small amount of variance in multivariate regression models supporting the hypothesis that other behavioural, sex hormone-related or genetic factors, which have not been sufficiently explored so far, may play a role in the gender differences of IMT.

  5. Predisposing Factors of Liver Necrosis after Transcatheter Arterial Chemoembolization in Liver Metastases from Neuroendocrine Tumor

    International Nuclear Information System (INIS)

    PurposeTo investigate predictive factors for liver necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine liver metastases.MethodsA total of 164 patients receiving 374 TACE were reviewed retrospectively to analyze predictive factors of liver necrosis. We analyzed patient age and sex; metastasis number and location; percentage of liver involvement; baseline liver function test; and pretreatment imaging abnormalities such as bile duct dilatation (BDD), portal vein narrowing (PVN), and portal vein thrombosis (PVT). We analyzed TACE technique such as Lipiodol or drug-eluting beads (DEB) as the drug’s vector; dose of chemotherapy; diameter of DEB; and number, frequency, and selectivity of TACE.ResultsLiver necrosis developed after 23 (6.1 %) of 374 TACE. In multivariate analysis, DEB > 300 μm in size induced more liver necrosis compared to Lipiodol (odds ratio [OR] 35.20; p < 0.0001) or with DEB < 300 μm in size (OR 19.95; p < 0.010). Pretreatment BDD (OR 119.64; p < 0.0001) and PVT (OR 9.83; p = 0.030) were predictive of liver necrosis. BDD or PVT responsible for liver necrosis were present before TACE in 59 % (13 of 22) and were induced by a previous TACE in 41 % (9 of 22) of cases.ConclusionDEB > 300 μm in size, BDD, and PVT are responsible for increased rate of liver necrosis after TACE. Careful analysis of BDD or PVT on pretreatment images as well as images taken between two courses can help avoid TACE complications

  6. Predisposing Factors of Liver Necrosis after Transcatheter Arterial Chemoembolization in Liver Metastases from Neuroendocrine Tumor

    Energy Technology Data Exchange (ETDEWEB)

    Joskin, Julien, E-mail: j.joskin@gmail.com; Baere, Thierry de, E-mail: Thierry.DEBAERE@igr.fr [Institut Gustave Roussy, Department of Interventional Radiology (France); Auperin, Anne, E-mail: Anne.AUPERIN@igr.fr [Institut Gustave Roussy, Department of Epidemiology (France); Tselikas, Lambros, E-mail: lambros.tselikas@gmail.com; Guiu, Boris, E-mail: boris.guiu@chu-dijon.fr; Farouil, Geoffroy, E-mail: g.farouil@gmail.com [Institut Gustave Roussy, Department of Interventional Radiology (France); Boige, Valérie, E-mail: boige@igr.fr; Malka, David, E-mail: david.malka@igr.fr [Institut Gustave Roussy, Department of Digestive Oncology (France); Leboulleux, Sophie, E-mail: sophie.leboulleux@igr.fr [Institut Gustave Roussy, Department of Nuclear Medicine and Endocrine Oncology (France); Ducreux, Michel, E-mail: ducreux@igr.fr [Institut Gustave Roussy, Department of Digestive Oncology (France); Baudin, Eric, E-mail: baudin@igr.fr [Institut Gustave Roussy, Department of Nuclear Medicine and Endocrine Oncology (France); Deschamps, Frédéric, E-mail: frederic.deschamps@igr.fr [Institut Gustave Roussy, Department of Interventional Radiology (France)

    2015-04-15

    PurposeTo investigate predictive factors for liver necrosis after transcatheter arterial chemoembolization (TACE) of neuroendocrine liver metastases.MethodsA total of 164 patients receiving 374 TACE were reviewed retrospectively to analyze predictive factors of liver necrosis. We analyzed patient age and sex; metastasis number and location; percentage of liver involvement; baseline liver function test; and pretreatment imaging abnormalities such as bile duct dilatation (BDD), portal vein narrowing (PVN), and portal vein thrombosis (PVT). We analyzed TACE technique such as Lipiodol or drug-eluting beads (DEB) as the drug’s vector; dose of chemotherapy; diameter of DEB; and number, frequency, and selectivity of TACE.ResultsLiver necrosis developed after 23 (6.1 %) of 374 TACE. In multivariate analysis, DEB > 300 μm in size induced more liver necrosis compared to Lipiodol (odds ratio [OR] 35.20; p < 0.0001) or with DEB < 300 μm in size (OR 19.95; p < 0.010). Pretreatment BDD (OR 119.64; p < 0.0001) and PVT (OR 9.83; p = 0.030) were predictive of liver necrosis. BDD or PVT responsible for liver necrosis were present before TACE in 59 % (13 of 22) and were induced by a previous TACE in 41 % (9 of 22) of cases.ConclusionDEB > 300 μm in size, BDD, and PVT are responsible for increased rate of liver necrosis after TACE. Careful analysis of BDD or PVT on pretreatment images as well as images taken between two courses can help avoid TACE complications.

  7. Factors associated with gender difference in the intima-media thickness of the common carotid artery

    Energy Technology Data Exchange (ETDEWEB)

    Tan, T.-Y.; Lu, C.-H.; Lin, T.-K.; Liou, C.-W. [Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); Chuang, Y.-C., E-mail: tengyeowtan@yahoo.co [Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan (China); Schminke, U. [Department of Neurology, Ernst Moritz Arndt University, Greifswald (Germany)

    2009-11-15

    Aim: To investigate the gender differences associated with a thinner intima-media thickness (IMT) of the common carotid artery (CCA) in women. Materials and methods: In a sample of 218 consecutive healthy volunteers comprising 110 men and 108 women, the IMT of the CCA was measured using B-mode ultrasonography. Blood pressure, fasting blood sugar, body mass index (BMI), blood lipid profile, homocysteine, folic acid, uric acid, high sensitive C-reactive protein, and thiobarbituric acid reactive substances (TBARS) levels were measured and compared with each other in both genders. Results: The IMT of the CCA was significantly thinner in women than in men (p = 0.012). Blood pressure, fasting plasma glucose, BMI, low-density lipoprotein cholesterol, triglycerides, homocysteine, uric acid, and TBARS were significantly (p < 0.05) lower, folic acid and high-density lipoprotein cholesterol (HDL-C) were significantly (p < 0.0001) higher in women compared with men. Multivariable logistic regression analysis revealed that higher serum levels of homocysteine, uric acid, and TBARS, and lower serum levels of HDL-C were significantly (p < 0.05) associated with male sex. Multiple linear regression analysis further revealed that age, sex, and BMI were independently associated with CCA IMT. Conclusions: The IMT of the CCA was thinner in women than in men. Traditional vascular risk factors explain only a small amount of variance in multivariate regression models supporting the hypothesis that other behavioural, sex hormone-related or genetic factors, which have not been sufficiently explored so far, may play a role in the gender differences of IMT.

  8. Cirurgia de revascularização do miocárdio usando apenas tomografia computadorizada como angiograma pré-operatório Cirugía de revascularización del miocardio usando sólo tomografía computada como angiograma preoperatorio Coronary artery bypass using only computed tomography as pre-operative angiogram

    Directory of Open Access Journals (Sweden)

    Diego Felipe Gaia

    2009-09-01

    Full Text Available A cirurgia de revascularização do miocárdio (CRM é um procedimento bem estabelecido com indicações atuais precisas. O advento e a disseminação dessa técnica foram possíveis após a introdução do angiograma coronário. Embora muitos métodos de avaliação tenham evoluído nos últimos anos, nenhum conseguiu substituir o angiograma coronário invasivo como exame pré-operatório. A tomografia computadorizada (TC emergiu como uma alternativa ao angiograma coronário invasivo. O presente relato descreve dois casos de CRM realizadas usando-se apenas a TC como técnica de avaliação anatômica das artérias coronárias pré-operatória.La cirugía de revascularización del miocardio (CRM es un procedimiento bien establecido con indicaciones actuales precisas. El advenimiento y la divulgación de esta técnica fueron posibles después de la introducción del angiograma coronario. Aunque muchos métodos de evaluación hayan evolucionados en los últimos años, ninguno ha conseguido sustituir al angiograma coronario invasivo como examen preoperatorio. La tomografía computada (TC surgió como una alternativa al angiograma coronario invasivo. El presente informe describe dos casos de CRM realizadas usando sólo la TC como técnica de evaluación anatómica de las arterias coronarias preoperatoria.Coronary artery bypass graft (CABG is a well established procedure with current precise indications. The advent and spread of this technique was possible after the introduction of the coronary angiogram. Although many evaluation methods have been developed in the past years, to date, none have been able to replace the invasive coronary angiogram as a pre-operative exam. Computed tomography angiography (CTA has emerged as an alternative to invasive coronary angiogram. In this report we describe two CABG cases that were performed using only this technique as a pre-operative anatomic coronary arteries evaluation.

  9. Prevalence of Risk Factors for Coronary Artery Disease in the Brazilian State of Rio Grande do Sul

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    Iseu Gus

    2002-05-01

    Full Text Available OBJECTIVE - To determine the risk factors prevalence for coronary artery disease in the State of Rio Grande do Sul, Brazil and to identify their relation with the age bracket. METHODS - We carried out an observational, cross-sectional study of 1,066 adults older than 20 years in the Brazilian State of Rio Grande do Sul. We investigated the risk factors: familial antecedents, systemic arterial hypertension, high levels of cholesterol and glycemia, overweight/obesity, smoking and sedentary lifestyle. A standardized questionnaire completed at the patients' dwellings by health agents were used; the data were stored in an EPI-INFO software database. The results were expressed with a 95% confidence interval. RESULTS - The sample composition was of 51.8% females. The risk factors prevalences were: 1 sedentary lifestyle 71.3%; 2 familial antecedents: 57.3%; 3 overweight/obesity (body mass index >25: 54.7%; 4 smokers: 33.9%; 5 hypertension: 31.6% (considering >140/90mmHg and 14.4% (considering >160/95mmHg; 6 high glycemia (>126 mg/dL: 7%; 7 high cholesterol >240 mg/dL: 5.6%. CONCLUSION - The prevalence of the major risk factors for coronary artery disease in the Brazilian state of Rio Grande do Sul could be determined in a study that integrated public and private institutions.

  10. Prevalence of Coronary Artery Disease Risk factors in Teachers Residing in Shiraz-Iran 2009

    Directory of Open Access Journals (Sweden)

    J Tahmasebi

    2010-06-01

    Full Text Available Background: coronary artery diseases (CAD are the leading cause of mortality, morbidity and disability with high health care cost in any countries including Iran. The prevalence of all CAD risk factors including hypertension, diabetes, lipid profile abnormalities and obesity is rising in the population of Iran. Knowing the population at risk would lead to proper education to decrease these risk factors and ultimately would reduce CAD.Methods: This descriptive cross- sectional study was conducted in February to December 2009 and comprised a total of 3115 Shiraz educational staff, aged 21- 73 years.Questionnaires were applied to collect information including; demographic data, physical activity, history of CAD, hypertension, dyslipidemia, and smoking. In addition, waist circumference, height, weight, body mass index (BMI, and hip circumference (HC were measured and serum biochemistry profiles were determined on venous blood samples. Such data helped identify the prevalence of diabetes, hypercholesterolemia, hypertriglyceridemia, hypertension, overweight and obesity, central obesity, and smoking. Results: The mean age of 3115 participant was 42.7 and 41.5 years for men and women respectively. The prevalence of pre-diabetes, diabetes hypertension, hypercholesterolemia and hypertriglyceridemia were %10.2, %4, %18.2, %38.30 and %33.2 respectively. Diabetes, hypertension and dyslipidemia were more prevalent among males and older subjects. The prevalence of central obesity was %75.05 (IDF criteria and %40.64 (ATP- III criteria. The frequency of obesity, current smoking, ex-smoking and passive smoking were %12.1, %5.85 , %1.52 ,%7.9 respectively which were below the reported prevalence in Iran in previous studies, but physical inactivity was %73.3 which is very high in this study group.Conclusion: Although CAD risk factors seem to be very common in the study population, clinical and paraclinical data indicated that teachers residing in Shiraz have a

  11. Factors Affecting the Quality and Quantity of Sleep in Coronary Artery Bypass Graft Patients

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    H Esmaily

    2008-10-01

    Full Text Available Introduction: Sleep disturbance is common in patients undergoing Coronary Artery Bypass Graft surgery and has been recognized for more than 30 years. New literature suggests the importance of sleep and rest for restoration, protection and promotion of function and wellbeing of these patients. Because of the importance of the role of nurses in diagnosis and treatment of sleep disorders, this study was conducted to determine possible effective factors on sleep quality and sleep quantity of patients after CABG. Methods: This longitudinal, descriptive and correlational study was conducted on 91 patients admitted to Imam Reza Hospital in Mashad City in 2005-2006. Subjects were selected according to inclusion and exclusion criteria. Data was collected by interview in three stages: 24 hours before surgery, as well as 6 weeks and 10 weeks after surgery. Subjective sleep quality was measured with PSQI and sleep quantity was measured with sleep log. The first two interviews were done at the hospital clinic and the last via telephone. Data was analyzed in SPSS using student T test, Pearson correlation coefficient and General Linear Model. Results: According to Univariable analysis, variables such as age (p=0.03, aorta clamp time (p=0.003, mechanical ventilation time (p=0.01, staying time in hospital (p=0.04 can affect sleep quantity 10 weeks after surgery. Previous history of sleep disorder (p=0.005, diabetes (p=0.02, use of diuretic drugs before surgery (p=0.04 and ACEI drugs after surgery (p=0.01 can affect sleep quality 10 weeks after surgery. Conclusion: Sleep disorder history (p=0.01, use of diuretic drugs before surgery (p=0.04 and sleep quantity 6 weeks after surgery (p=0.01 have been the most effective factors on sleep quality 10 weeks after surgery, whereas quality of life 10 weeks after surgery (p=0.04 has been the most effective factor on sleep quantity 10 weeks after surgery. There is therefore a necessity for presenting approaches in order to

  12. Baseline Characteristics and Risk Factors of Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus Patients.

    Science.gov (United States)

    Huang, Can; Li, Mengtao; Liu, Yongtai; Wang, Qian; Guo, Xiaoxiao; Zhao, Jiuliang; Lai, Jinzhi; Tian, Zhuang; Zhao, Yan; Zeng, Xiaofeng

    2016-03-01

    Peking Union Medical College Hospital (PUMCH) has started a single-center right heart catheterization (RHC)-based pulmonary arterial hypertension (PAH) study in systemic lupus erythematosus (SLE) since 2006. The baseline characteristics of these patients were described and the risk factor for PAH in lupus was identified.The demographic, clinical, laboratory, and treatment characteristics of SLE patients with PAH when they were registered were collected as the baseline data. A case-control study was conducted by taking the admitted SLE-non-PAH patients adjusted for age and gender in a 4:1 ratio during the same period as the controls. The associated variables were examined by binary multivariate logistic regression analysis to identify possible risk factors. A total of 111 RHC-confirmed SLE-PAH patients were enrolled, with the onset age of 34.6 ± 8.6 years old and the average SLE duration of 5 years. RHC revealed mPAP as 46.4 ± 11.4 mm Hg, CI as 2.7 ± 0.8 L/min × m, and PVR as 10.5 ± 4.8 WU. 46% of patients were WHO Fc I-II. All patients were treated with immunosuppressive agents and 65% patients had PAH-targeted therapy. The case-control study had confirmed 2 independent risk factors previously published: pericardial effusion (OR = 21.290, P RNP antibody (OR = 12.399, P antibody (OR = 4.836, P = 0.004), SLEDAI≤9 (OR = 26.426, P  357 μmol/L (OR = 9.666, P RNP antibody are risk factors for SLE-associated PAH. Long SLE disease duration, the presence of interstitial lung disease, without acute skin rash, positive anti-SSA antibody, low SLEDAI and ESR, and high uric acid levels are also associated with PAH in SLE patients. PMID:26962774

  13. Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.

    Directory of Open Access Journals (Sweden)

    Sylvia T Nurnberg

    2015-05-01

    Full Text Available Recent genome wide association studies have identified a number of genes that contribute to the risk for coronary heart disease. One such gene, TCF21, encodes a basic-helix-loop-helix transcription factor believed to serve a critical role in the development of epicardial progenitor cells that give rise to coronary artery smooth muscle cells (SMC and cardiac fibroblasts. Using reporter gene and immunolocalization studies with mouse and human tissues we have found that vascular TCF21 expression in the adult is restricted primarily to adventitial cells associated with coronary arteries and also medial SMC in the proximal aorta of mouse. Genome wide RNA-Seq studies in human coronary artery SMC (HCASMC with siRNA knockdown found a number of putative TCF21 downstream pathways identified by enrichment of terms related to CAD, including "vascular disease," "disorder of artery," and "occlusion of artery," as well as disease-related cellular functions including "cellular movement" and "cellular growth and proliferation." In vitro studies in HCASMC demonstrated that TCF21 expression promotes proliferation and migration and inhibits SMC lineage marker expression. Detailed in situ expression studies with reporter gene and lineage tracing revealed that vascular wall cells expressing Tcf21 before disease initiation migrate into vascular lesions of ApoE-/- and Ldlr-/- mice. While Tcf21 lineage traced cells are distributed throughout the early lesions, in mature lesions they contribute to the formation of a subcapsular layer of cells, and others become associated with the fibrous cap. The lineage traced fibrous cap cells activate expression of SMC markers and growth factor receptor genes. Taken together, these data suggest that TCF21 may have a role regulating the differentiation state of SMC precursor cells that migrate into vascular lesions and contribute to the fibrous cap and more broadly, in view of the association of this gene with human CAD, provide

  14. Spontaneous coronary artery dissection causing acute coronary syndrome in a young patient without risk factors

    OpenAIRE

    Chevli, Parag; Kelash, Fnu; Gadhvi, Pragnesh; Grandhi, Sreeram; Syed, Amer

    2014-01-01

    Spontaneous coronary artery dissection (SCAD) is a rare cause of acute myocardial infarction that is more common in younger patients (under age 50) and in women. Although the etiology is not known, some predisposing conditions to SCAD are well known and include Marfan syndrome, pregnancy and peripartum state, drug abuse, and some anatomical abnormalities of the coronary arteries such as aneurysms and severe kinking. We describe a case of SCAD in a young woman who presented with sudden onset o...

  15. Factors Affecting the Response to Exercise in Patients with Severe Pulmonary Arterial Hypertension

    OpenAIRE

    Flox-Camacho, Ángela; Escribano Subías, Pilar; Jiménez-Lépez Guarch, Carmen; Fernández Vaquero, Almudena; Martín Ríos, María Dolores; Saenz de la Calzada-Campo, Carlos

    2011-01-01

    Introduction: Ergospirometry objectively quantifies exercise capacity. Up until now, the response to exercise evaluated by ergospirometry in patients with pulmonary arterial hypertension has only been described in recently diagnosed.patients. Our aim is to describe the response to exercise in patients with severe pulmonary arterial hypertension under specific treatment and define which parameters determine their exercise capacity. Patients and method: A cross-sectional study was performed on ...

  16. El turismo como factor de reconversión productiva local en la ciudad de Ushuaia,República Argentina

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    Noemí Wallingre

    2004-11-01

    Full Text Available El presente trabajo de investigación, realizado a partir del análisis de caso de la ciudad de Ushuaia, Argentina, pretende probar empíricamente y con carácter inédito que el turismo es un factor de reconversión productiva local y que puede constituirse en nueva estrategia para impulsar el desarrollo de aquellas localidades poseedoras de potencial turístico y mejorar la calidad de vida de la comunidad. Para su demostración se incluyó un análisis comparativo entre los factores tradicionales de desarrollo y turismo, a partir del análisis de las variables generación de ingresos económicos, crecimiento de empresas y de puestos de trabajo. Se analizó, además, la existencia e implementación de algún tipo de estrategia para el desarrollo del turismo y si la misma generó un incremento en la oferta y en la demanda turística, así como en la generación de nuevos empleos.

  17. Effect of heterozygous β-thalassaemia trait on coronary atherosclerosis via coronary artery disease risk factors: a preliminary study

    OpenAIRE

    Hashemi, M.; Shirzadi, E; Talaei, Z; L. Moghadas; Shaygannia, I; Yavari, M; AMIRI, N.; H. Taheri; H. Montazeri; Shamsolkottabi, H

    2007-01-01

    Summary Background Thalassaemia is considered the most common genetic disorder worldwide. An association between the heterozygous β-thalassaemia trait and myocardial infarction has previously been observed. However, the relationship between heterozygous β-thalassaemia and atherosclerosis, considering other coronary artery disease (CAD) risk factors, has remained unclear. Methods A case-control study was conducted to evaluate the hypothesis that thalassaemia minor affects the likelihood of ath...

  18. Release of soluble vascular endothelial growth factor receptor-1 (sFlt-1) during coronary artery bypass surgery

    OpenAIRE

    Orsel Isabelle; Laskar Marc; Cornu Elisabeth; Leguyader Alexandre; Denizot Yves; Vincent Christelle; Nathan Nathalie

    2007-01-01

    Abstract Background This study was conducted to follow plasma concentrations of sFlt-1 and sKDR, two soluble forms of the vascular endothelial growth factor (VEGF) receptor in patients undergoing coronary artery bypass graft (CABG) surgery with extracorporeal circulation (ECC). Methods Plasma samples were obtained before, during and after surgery in 15 patients scheduled to undergo CABG. Levels of sFlt-1 and KDR levels were investigated using specific ELISA. Results A 75-fold increase of sFlt...

  19. El grosor íntima-media de la arteria femoral superficial como marcador de la aterosclerosis y de la enfermedad arterial periférica

    OpenAIRE

    Arnedo Valero, Gemma

    2016-01-01

    1-Introducción: El grosor íntima-media (GIM) de la arteria carótida, medido con eco-doppler, es considerado un marcador precoz de las enfermedades cardiovasculares121. La enfermedad arterial periférica es una enfermedad altamente costosa y prevalente1-3. El gold-estándar para su diagnóstico es el índice tobillo-brazo (ITB). Éste guarda una estrecha relación con los eventos cardiovasculares y su pronóstico132. La exploración con eco-doppler de la arteria femoral superficial es má...

  20. Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats.

    Science.gov (United States)

    Fujimoto, Masashi; Shiba, Masato; Kawakita, Fumihiro; Liu, Lei; Nakasaki, Asuka; Shimojo, Naoshi; Imanaka-Yoshida, Kyoko; Yoshida, Toshimichi; Suzuki, Hidenori

    2016-07-01

    Tenascin-C (TNC), one of matricellular proteins, has been suggested to be involved in cerebral vasospasm after aneurysmal subarachnoid hemorrhage. However, the mechanisms of how TNC constricts cerebral arteries remain unclear. The aim of this study was to examine if epidermal growth factor (EGF)-like repeats of TNC is involved in TNC-induced constriction of cerebral arteries in rats via EGF receptor (EGFR) activation. Two dosages of recombinant TNC (r-TNC) consisting of the EGF-like repeats was administered intracisternally to healthy rats, and its vasoconstrictor effects were evaluated by neurobehavioral tests and India-ink angiography at 24, 48, and 72 hours after the administration. Western blotting and immunohistochemistry were performed to explore the underlying mechanisms on constricted cerebral arteries after 24 hours. The effects of a selective EGFR tyrosine kinase inhibitor (AG1478) on r-TNC-induced vasoconstriction were evaluated by neurobehavioral tests, India-ink angiography and immunohistochemistry at 24 hours after the administration. A higher dosage of r-TNC induced cerebral arterial constriction more severely, which continued for 48 hours. The effects were associated with the activation of EGFR and extracellular signal-regulated kinase (ERK)1/2 in the smooth muscle cell layer of the constricted cerebral artery, while c-Jun N-terminal kinase and p38 were not activated. AG1478 blocked r-TNC-induced vasoconstrictive effects, as well as activation of EGFR and ERK1/2. These findings demonstrate that TNC induces constriction of cerebral arteries via activation of EGFR and ERK1/2. PMID:27086972

  1. Cardiovascular Risk Factors in Young Patients of Coronary ArteryDisease: Differences over a Decade

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    Amitesh Aggarwal

    2014-10-01

    Full Text Available Introduction: Studies evaluating temporal trends of Coronary artery disease (CAD in youngpatients, from the India, are still lacking. The aim of this study was to evaluate temporal differencesin risk factors of young patients of CAD over a decade.Methods: This is a single centre retrospective study performed in a tertiary care teaching institutionin North India. Case records of young patients (≤40 years with acute coronary syndrome betweenJanuary 2000 to December 2001 and January 2009 to December 2010 were obtained. Recordswere sought for active smoking, family history, waist size, blood pressure, hypertension, fastingand postprandial blood sugar and lipid profile for both groups and analyzed using SPSS v.17. Forthe purpose of the study, p value <0.05 was considered statistically significant.Results: Medical records of a total of 79 and 83 patients with young CAD (≤ 40 years wereobtained for 2000-01 and 2009-10 period respectively. An increase in proportion of femalepatients, hypertension (p=0.004, dysglycemia (p<0.001, family history (p=0.01, metabolicsyndrome (p<0.001, low high density lipoprotein (HDL (p=0.07 and mean waist size (0.03was noted over the years. Among males, increase in number of dysglycemics (p=0.0002, positivefamily history (p<0.0001 and mean waist size (0.032 was statistically significant.Conclusion: Over a decade the patients with young CAD in our study, there was an increase inproportion of patients with metabolic syndrome, dysglycemia and low HDL.

  2. Arterial embolization for management of hemoptysis in pulmonary tuberculosis : factors of rebleeding

    International Nuclear Information System (INIS)

    To evaluate the effectiveness of arterial embolization in reducing hemoptysis in pulmonary tuberculosis, and rebleeding factors after embolization. Fifty-nine patients with massive or recurrent hemoptysis from pulmonary tuberculosis were underwent percutaneous transcatheter embolotherapy and thirteen were subsequently operated on. In 46 patients, we retrospectively analyzed on plain chest PA the extent of pulmonary tuberculosis lesions, the period from initial diagnosis to embolization, and angiographic findings. The extent of lesions shown on plain chest PA were classified into minimal, moderately advanced, and far advanced. If there was no evidence of rebleeding after the first embolization,this was regarded as initial success in the control of hemoptysis. Angiographic findings were classified into hypervascularity, shunt, aneurysmal dilatation, and extravasation. Using the chi-square test, differences in these findings between rebleedig and non-rebleeding cases were anlysed. Immediate control of hemoptysis was achieved in 27 (58.7%) of 46 patients. Hemoptysis recurred in 19 (41.3%) of 46 patients followed up. Rebleeding cases showed more nonbronchial systemic collateral vessels and shunt than non-rebleeding cases (p<0.05). More advanced lesions of pulmonary tuberculosis on plain chest PA showed an increased rebleeding rate after embolization, but this was not statistically significant. There was no correlation between the period from initial diagnosis of pulmonary tuberculosis to embolization and the rate of rebleeding. But the longer the period, the greater the number of nonbronchial systemic collateral vessels. In cases with more advanced lesions of pulmonary tuberculosis on plain chese PA and a long period from initial diagnosis of pulmonary tuberculosis to embolization, angiographic findings showed numerous nonbronchial systemic collateral vessels but increases in the rebleeding rate were statistically not significant. The greater the number of nonbronchial

  3. 18F-fluoroethylcholine uptake in arterial vessel walls and cardiovascular risk factors. Correlation in a PET-CT study

    International Nuclear Information System (INIS)

    Fluorine-labelled choline derivatives were recently suggested as agents for visualizing vulnerable atherosclerotic plaques. We therefore aimed to evaluate the association between 18F-fluorethylcholine (FEC) uptake in the wall of large arteries, where calcification was also measured, with the presence of cardiovascular risk factors and occurrence of prior cardiovascular events. Detailed clinical information, including common cardiovascular risk factors, was obtained retrospectively in 60 prostate cancer patients examined with whole-body FEC PET-CT. In each patient, we calculated the mean blood pool-corrected SUV, as well as the mean target-to-background ratio (TBR), in addition to the sum of calcified plaques (CPsum) from six major vessels: ascending and descending aorta, aortic arch, abdominal aorta, and both iliac arteries. As reported previously, the CPsum correlated significantly with cardiovascular risk factors, in contrast to mean SUV or TBR scores, which did not show any significance with the presence of cardiovascular risk factors. There was no correlation between CPsum, mean TBR or SUV, nor was there any significant association of CPsum, mean TBR or SUV with the prior occurrence of cardio- or cerebrovascular events. Contrary to a recent report, we found in our rather large cohort of elderly prostate cancer patients no significant association between FEC uptake in large vessels and atherosclerotic plaque burden, or the presence of cardiovascular risk factors. In line with prior reports on structural changes in vessels, increased calcified atherosclerotic plaque burden was strongly associated with the occurrence of common cardiovascular risk factors. (orig.)

  4. Factors Associated with Coronary Artery Disease in Young Population (Age≤40):Analysis with 217 Cases

    Institute of Scientific and Technical Information of China (English)

    Wei-xian Yang; Zheng Yang; Yong-jian Wu; Shu-bin Qiao; Yue-jin Yang; Ji-lin Chen

    2014-01-01

    Objective To investigate the relevant factors of coronary artery disease (CAD) in young people under 40 years of age. Methods The study population was 292 young patients accepting coronary angiography in Fuwai Hospital from July to December 2006, including 272 men and 20 women, with the mean age being 36.7±3.7 years. The diagnosis of CAD was made in the cases presenting ≥50%stenosis in coronary lumen in coronary angiography. Based on the diagnosis, 217 patients (204 men, 13 women) were assigned to CAD group, and 75 (68 men, 7 women) to non-CAD group. Clinical data and metabolic characteristics of the patients were collected and analyzed using t-test,χ2 test, and multinomial logistic regression with SPSS 8.0 software. Results Most study subjects were current smokers (209/292, 71.6%), and more than half had body mass index (BMI)>24 kg/m2 (230/292, 78.8%) and usually took high-fat diet (162/292, 55.5%). The proportion of heavy smokers (smoking history ≥10 years and ≥20 cigarettes per day) were significantly higher in the CAD group than in the non-CAD group [20.7%(45/217) vs. 9.3%(7/75), P=0.015)]. Heavy smoking [odds ratio (OR), 1.89;95%confidence interval (CI), 1.74-2.05], hypertension (OR, 1.56;95%CI, 1.48-1.65), alcohol (OR, 1.37;95%CI, 1.30-1.46), type 2 diabetes mellitus (OR, 1.37;95%CI, 1.25-1.50), high-fat diet (OR, 1.35;95% CI, 1.28-1.43), and BMI>24 kg/m2 (OR, 1.09;95% CI, 1.03-1.17) were factors related to CAD in the young patients (all P Conclusions Heavy smoking, hypertension, alcohol consumption, type 2 diabetes mellitus, high-fat diet and BMI>24 kg/m2 were significantly related to CAD in patients aged ≤ 40, with heavy smoking presenting the highest OR. Metabolic syndrome and inflammation were also more common in young CAD patients than in non-CAD patients.

  5. El factor de crecimiento transformante beta como blanco terapéutico Transforming growth factor-beta as a therapeutic target

    Directory of Open Access Journals (Sweden)

    Francisco Javier Gálvez-Gastélum

    2004-08-01

    Full Text Available El factor de crecimiento transformante beta (TGF-beta es una familia de proteínas que incluye al TGF-beta, activinas y a la proteína morfogénica de hueso (BMP, por sus siglas en inglés, citocinas que son secretadas y se relacionan estructuralmente en diferentes especies de metazoarios. Los miembros de la familia del TGF-beta regulan diferentes funciones celulares como proliferación, apoptosis, diferenciación, migración, y tienen un papel clave en el desarrollo del organismo. El TGF-beta está implicado en varias patologías humanas, incluyendo desórdenes autoinmunes y vasculares, así como enfermedades fibróticas y cáncer. La activación del receptor del TGF-beta propicia su fosforilación en residuos de serina/treonina y dispara la fosforilación de proteínas efectoras intracelulares (smad, que una vez activas se translocan al núcleo para inducir la transcripción de genes blanco, y así regular procesos y funciones celulares. Se están desarrollando novedosas estrategias terapéuticas encaminadas a corregir las alteraciones presentes en patologías que involucran al TGF-beta como actor principal.Transforming growth factor-beta (TGF-beta family members include TGF-beta, activins, and bone morphogenetic proteins (BMP. These proteins are structurally related cytokines secreted in diverse Metazoans. TGF-beta family members regulate cellular functions such as proliferation, apoptosis, differentiation, and migration, and play an important role in organism development. Deregulated TGF-beta family signaling participates in various human pathologies including auto-immune diseases, vascular disorders, fibrotic disease, and cancer. Ligand-induced activation of TGF-beta family receptors with intrinsic serine/threonine kinase activity, triggers phosphorylation of the intracellular effectors of TGF-beta signaling, the Smads proteins. Once these proteins are activated they translocate into the nucleus, where they induce transcription of target

  6. Association of usf1s2 variant in the upstream stimulatory factor 1 gene with premature coronary artery disease in southern population of Iran

    Directory of Open Access Journals (Sweden)

    Najmeh Jouyan

    2015-03-01

    Conclusion: It appears that the usf1s2 variant in upstream transcription factor 1 gene is an independent predictor of premature coronary artery disease in our population and applies its effects without affecting blood sugar and lipid levels.

  7. Spontaneous coronary artery dissection causing acute coronary syndrome in a young patient without risk factors

    Directory of Open Access Journals (Sweden)

    Parag Chevli

    2014-09-01

    Full Text Available Spontaneous coronary artery dissection (SCAD is a rare cause of acute myocardial infarction that is more common in younger patients (under age 50 and in women. Although the etiology is not known, some predisposing conditions to SCAD are well known and include Marfan syndrome, pregnancy and peripartum state, drug abuse, and some anatomical abnormalities of the coronary arteries such as aneurysms and severe kinking. We describe a case of SCAD in a young woman who presented with sudden onset of chest pain and was admitted for the treatment of acute coronary syndrome. The coronary angiography showed dissection of the left anterior descending artery. The patient underwent successful percutaneous transluminal coronary angioplasty and stent placement.

  8. Recurrent Bleeding Within 24 Hours After Uterine Artery Embolization for Severe Postpartum Hemorrhage: Are There Predictive Factors?

    International Nuclear Information System (INIS)

    Purpose: To retrospectively identify predictive factors of recurrent bleeding within 24 h after uterine artery embolization (UAE) for postpartum hemorrhage (PPH). Materials and Methods: A total of 194 patients underwent UAE for PPH between August 1999 and April 2009 at our institution. Twelve patients experienced recurrent bleeding within the next 24 h; a second attempt at UAE was thus necessary, which was successful in 10 cases. In two cases, hemostatic hysterectomy was performed. Epidemiological, gynecological-obstetrical, anatomic, and biological data were analyzed. Results: Complete data were available for 148 of the 194 (76%) included patients. Sixty-four (43%) were primiparous, 18 (12.2%) had a placenta accreta, 21 (14%) had a coagulopathy, and 28 (18.9%) had an anatomic variant of the uterine arterial vasculature. Mean age and pregnancy term were similar in both recurring and nonrecurrent bleeding groups. After multivariate analysis, three criteria emerged as risk factors of recurrent bleeding: primiparity (10 patients, 83%; odds ratio [OR] = 18.84; P = 0.014), coagulation disorders (6 patients, 50%; OR = 12.08; P = 0.006), and anatomic variant of the uterine arterial vasculature (28 patients; OR = 9.83; P = 0.003). Conclusions: earch for uterine collaterals must be performed before UAE for PPH. Primiparity and coagulation disorders increase the risk of recurrent bleeding after UAE for PPH.

  9. Diferencia veno-arterial de dióxido de carbono como predictor de gasto cardiaco disminuido en modelo pediátrico experimental

    Directory of Open Access Journals (Sweden)

    Franco Díaz

    2012-01-01

    Full Text Available Background: Cardiac output (CO measurement is not a standard of care for critically ill children, but it can be estimated by indirect methods such as veno-arterial pCO2 difference (ΔVACO2. Aim: To determine the correlation between CO and ΔVACO2 and evaluate the usefulness of ΔVACO2 in the diagnosis of low CO in an experimental pediatric model. Materials and Methods: Thirty piglets weighing 4.8 ± 0.35 kg were anesthetized and monitored with transpulmonary thermodilution. Lung injury was induced with tracheal instillation of Tween 20®. Serial measurements of central venous and arterial blood gases, as well as CO, were obtained at baseline, 1, 2 and 4 h after lung injury induction. Low cardiac output (LCO was defined as CO lower than 2.5 Llminlm². Results: There was an inverse correlation between CO and ΔVACO2 (r = -0.36, p < 0.01. ΔVACO2 was 14 ± 8 mmHg in LCO state and 8 ± 6 mmHg when this condition was not present (p < 0.01. Area under the receiver operating characteristic (ROC curves of ΔVACO2 and LCO state was 0.78 (0.68-0.86. The best cut-point was 8.9 mmHg to determine LCO with a sensibility 0.78, specificity 0.7, positive predictive value 0.27 and negative predictive value 0.96. Conclusions: In this model there was an inverse correlation between ΔVACO2 and CO. The best cutoff value to discard LCO was ΔVACO2 of 8.9 mmHg, indicating that under this value the presence of LCO is very unlikely.

  10. Factors Influencing the Disturbed Flow Patterns Downstream of Curved Atherosclerotic Arteries

    Institute of Scientific and Technical Information of China (English)

    Biyue Liu

    2008-01-01

    Pulsatile blood flows in curved atherosclerotic arteries are studied by com-puter simulations. Computations are carried out with various values of physiological parameters to examine the effects of flow parameters on the disturbed flow patterns downstream of a curved artery with a stenosis at the inner wall. The numerical re-sults indicate a strong dependence of flow pattern on the blood viscosity and inlet flow rate, while the influence of the inlet flow profile to the flow pattem in downstream is negligible.

  11. Presion arterial en adolescentes mexicanos: clasificacion, factores de riesgo e importancia

    OpenAIRE

    Salcedo Rocha, Ana Leticia; García de Alba-Garcia, Javier Eduardo; Contreras Marmolejo, Margarita

    2014-01-01

    RESUMEN Objetivo: Determinar características de riesgo y la frecuencia de niveles de presión arterial de acuerdo a los dos criterios clasificatorios: JNC VII y 4º Reporte del grupo de trabajo para el diagnostico, evaluación y tratamiento de la hipertensión arterial en niños y adolescentes. En un grupo de escolares de 12 a 16 años de la ciudad de León. México Métodos: Estudio observacional, descriptivo, transversal de 458 adolescentes varones de la ciudad de León, Méxi...

  12. Factores clave en la enseñanza-aprendizaje de español como lengua extranjera (E/LE

    Directory of Open Access Journals (Sweden)

    Mabel Abad

    2006-06-01

    Full Text Available Se transcriben a continuación las presentaciones de las profesoras Mabel Abad y Gloria Toledo, leídas en la entrega de Certificados del Diplomado de Especialización en Español como Lengua Extranjera en noviembre del año 2005. “Factores clave en la enseñanza-aprendizaje de E/LE” corresponde a una reflexión en dos partes. La primera, de la profesora Mabel Abad, destaca los elementos de comunicación eficientes que deben enseñarse y practicarse para lograr demostrar la precisión en el desempeño de la segunda lengua, en el desafío que plantea el nuevo ambiente sociocultural al estudiante E/LE. La segunda, de la profesora Gloria Toledo, considera los contenidos y los modelos de ejercicios y estrategias indispensables para alcanzar la competencia de las cuatro habilidades lingüísticas en la planificación de la clase E/LE. (“Key factors in Teaching and Learning SSL” transcripts the presentation of the authors, Mabel Abad and Gloria Toledo, given on occasion of the Graduation Ceremony for specialists in SSL of the Pontificia Universidad Católica de Chile certificate course (Nov. 2005. This article is a reflection in two sections: the first one, Prof. Abad, highlights the effective communication elements that should be considered in teaching and therefore practiced in SSL in order to attain accurate proficiency. Prof. Gloria Toledo, in the second section, considers contents, strategies and a variety of model practice effective in planning a SSL lesson.

  13. Função endotelial de adolescentes normotensos sem fatores de risco para hipertensão arterial Endothelial function of normotensive adolescents with no risk factors for arterial hypertension

    Directory of Open Access Journals (Sweden)

    Zélia M. de Andrade

    2005-10-01

    Full Text Available OBJETIVO: Definir padrões de normalidade da função endotelial de adolescentes através de avaliação ultra-sonográfica da dilatação vascular dependente do endotélio. MÉTODOS: Estudo descritivo observacional de corte transversal, parte do projeto temático "Estudos Clínicos de Crescimento, Comportamento, Hipertensão Arterial, Obesidade e Saúde Bucal", de sigla ECCCHOS, desenvolvido na Disciplina de Nutrologia da Universidade Federal de São Paulo - Escola Paulista de Medicina. Foram selecionados 31 adolescentes, sendo oito do sexo masculino e 23 do feminino, sem fatores de risco conhecidos para hipertensão arterial sistêmica, entre 1.420 alunos de uma escola de ensino médio da cidade de São Paulo, capital do estado de São Paulo, situado no Sudeste do Brasil. Para apresentação de todos os resultados, utilizaram-se as médias, desvios padrão e percentis. RESULTADOS: A dilatação vascular dependente do endotélio 90 segundos pós-liberação do manguito foi de 20,9±6,7% [média mais ou menos 1 desvio padrão (DP] e o 10° percentil ficou em 12,5% no sexo masculino e de 18,8±12,9% DP e o 10° percentil em 6,6% no sexo feminino. Os valores no grupo todo foram de 19,3±11,7% e 6,7%, respectivamente. CONCLUSÃO: O 10° percentil (6,7% da curva de distribuição dos valores de dilatação vascular dependente do endotélio, em adolescentes do presente estudo, pode ser considerado como limite inferior da normalidade. O conhecimento desse limite é importante para o diagnóstico de disfunções endoteliais que aparecem antes das doenças cardiovasculares.OBJECTIVE: To define standards for normal endothelial function in adolescents by high-resolution ultrasound measurement of endothelium-dependent vascular dilatation. METHODS: This was a cross-sectional, descriptive, observational study and part of the thematic project "Clinical Study of Growth, Behavior, Arterial Hypertension, Obesity and Oral Health" (ECCCHOS that was developed by

  14. Ultrasound evaluation of intima media thickness of carotid arteries in dialysis patients and correlation with proposed risk factors

    Directory of Open Access Journals (Sweden)

    Damjanović Tatjana

    2003-01-01

    Full Text Available Atherosclerosis is significant risk factor for cardiovascular morbidity and mortality in dialysis patients. Aim of the study was ultrasound evaluation of intima media thickness on carotid arteries (as a marker of atherosclerosis, in dialysis patients and its correlation with proposed risk factors. Intima media thickness was measured in 45 dialysis patients with no signs of cardiovascular diseases (15 on peritoneal dialysis, group I,30 on hemodialysis, group II and 20 healthy controls. The mean carotid artery intima media thickness was significantly higher in dialysis patients than in control group. According to intima media thickness, dialysis patients were divided in group A (patient with intima media thickness less or equal 0,720 mm and group B (intima media thickness higher then 0,720mm. Intima media thickness in bout group was correlated with proposed risk factors. In group A there was not significant correlation of intima media thickness with risk factors. In group B significant correlation have been found between intima media thickness and LDL, VLDL cholesterol, body mass index and systolic, diastolic and mean blood pressure. Although atherosclerosis was not the only cause for cardiovascular morbidity and mortality, it has a dominant role in dialysis patients. Augmented intima media thickness could be early marker of atherosclerosis. The risk factors of great influence on intima media thickness are lipid disturbances, obesity and hypertension.

  15. Perioperative risk factors for prolonged mechanical ventilation and tracheostomy in women undergoing coronary artery bypass graft with cardiopulmonary bypass

    Directory of Open Access Journals (Sweden)

    Zahra S Faritous

    2011-01-01

    Full Text Available Background: Prolonged mechanical ventilation is an important recognized complication occurring during cardiovascular surgery procedures. This study was done to assess the perioperative risk factors related to postoperative pulmonary complications and tracheostomy in women undergoing coronary artery bypass graft with cardiopulmonary bypass. Methods: It was a retrospective study on 5,497 patients, including 31 patients with prolonged ventilatory support and 5,466 patients without it; from the latter group, 350 patients with normal condition (extubated in 6-8 hours without any complication were selected randomly. Possible perioperative risk factors were compared between the two groups using a binary logistic regression model. Results: Among the 5,497 women undergoing coronary artery bypass graft (CABG, 31 women needed prolonged mechanical ventilation (PMV, and 15 underwent tracheostomy. After logistic regression, 7 factors were determined as being independent perioperative risk factors for PMV. Discussion: Age ≥70 years old, left ventricular ejection fraction (LVEF ≤30%, preexisting respiratory or renal disease, emergency or re-do operation and use of preoperative inotropic agents are the main risk factors determined in this study on women undergoing CABG.

  16. Leukemia Inhibitory Factor (LIF) Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in Mice.

    Science.gov (United States)

    Winship, Amy; Correia, Jeanne; Zhang, Jian-Guo; Nicola, Nicos A; Dimitriadis, Evdokia

    2015-01-01

    The placenta forms the interface between the maternal and fetal circulation and is critical for the establishment of a healthy pregnancy. Trophoblast cell proliferation, migration and invasion into the endometrium are fundamental events in the initiation of placentation. Leukemia inhibitory factor (LIF) has been shown to promote trophoblast invasion in vitro, however its precise role in trophoblast invasion in vivo is unknown. We hypothesized that LIF would be required for normal trophoblast invasion and spiral artery remodeling in mice. Both LIF and its receptor (LIFRα) co-localized with cytokeratin-positive invasive endovascular extravillous trophoblasts (EVT) in mouse implantation sites during mid-gestation. Temporally blocking LIF action during specific periods of placental development via administration of our unique LIFRα antagonist, PEGLA, resulted in abnormal trophoblast invasion and impaired spiral artery remodeling compared to PEG control. PEGLA-treated mouse decidual vessels were characterized by retention of α-smooth muscle actin (αSMA)-positive vascular smooth muscle cells (VSMCs), while PEG control decidual vessels were remodelled by cytokeratin-positive trophoblasts. LIF blockade did not alter F4/80-positive decidual macrophage numbers between treatment groups, but resulted in down-regulation of decidual transcript levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-10 (IL-10), which are important immune cell activation factors that promote spiral artery remodeling during pregnancy. Our data suggest that LIF plays an important role in trophoblast invasion in vivo and may facilitate trophoblast-decidual-immune cell cross talk to enable adequate spiral artery remodeling. PMID:26479247

  17. Leukemia Inhibitory Factor (LIF Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in Mice.

    Directory of Open Access Journals (Sweden)

    Amy Winship

    Full Text Available The placenta forms the interface between the maternal and fetal circulation and is critical for the establishment of a healthy pregnancy. Trophoblast cell proliferation, migration and invasion into the endometrium are fundamental events in the initiation of placentation. Leukemia inhibitory factor (LIF has been shown to promote trophoblast invasion in vitro, however its precise role in trophoblast invasion in vivo is unknown. We hypothesized that LIF would be required for normal trophoblast invasion and spiral artery remodeling in mice. Both LIF and its receptor (LIFRα co-localized with cytokeratin-positive invasive endovascular extravillous trophoblasts (EVT in mouse implantation sites during mid-gestation. Temporally blocking LIF action during specific periods of placental development via administration of our unique LIFRα antagonist, PEGLA, resulted in abnormal trophoblast invasion and impaired spiral artery remodeling compared to PEG control. PEGLA-treated mouse decidual vessels were characterized by retention of α-smooth muscle actin (αSMA-positive vascular smooth muscle cells (VSMCs, while PEG control decidual vessels were remodelled by cytokeratin-positive trophoblasts. LIF blockade did not alter F4/80-positive decidual macrophage numbers between treatment groups, but resulted in down-regulation of decidual transcript levels of monocyte chemoattractant protein-1 (MCP-1 and interleukin-10 (IL-10, which are important immune cell activation factors that promote spiral artery remodeling during pregnancy. Our data suggest that LIF plays an important role in trophoblast invasion in vivo and may facilitate trophoblast-decidual-immune cell cross talk to enable adequate spiral artery remodeling.

  18. Prevalência de hipertensão arterial em militares jovens e fatores associados Prevalencia de hipertensión arterial en militares jóvenes y factores asociados Prevalence of arterial hypertension in young military personnel and associated factors

    Directory of Open Access Journals (Sweden)

    Daniela Wenzel

    2009-10-01

    Full Text Available OBJETIVO: Estimar a prevalência de hipertensão arterial entre militares jovens e fatores associados. MÉTODOS: Estudo transversal realizado com amostra de 380 militares do sexo masculino de 19 e 35 anos de idade em uma unidade da Força Aérea Brasileira em São Paulo, SP, entre 2000 e 2001. Os pontos de corte para hipertensão foram: >140mmHg para pressão sistólica e > 90mmHg para pressão diastólica. As variáveis estudadas incluíram fatores de risco e de proteção para hipertensão, como características comportamentais e nutricionais. Para análise das associações, utilizou-se regressão linear generalizada múltipla, com família binomial e ligação logarítmica, obtendo-se razões de prevalências com intervalo de 90% de confiança e seleção hierarquizada das variáveis. RESULTADOS: A prevalência de hipertensão arterial foi de 22% (IC 90%: 21;29. No modelo final da regressão múltipla verificou-se prevalência de hipertensão 68% maior entre os ex-fumantes em relação aos não fumantes (IC 90%: 1,13;2,50. Entre os indivíduos com sobrepeso (índice de massa corporal - IMC de 25 a 29kg/m2 e com obesidade (IMC>29kg/m2 as prevalências foram, respectivamente, 75% (IC 90%: 1,23;2,50 e 178% (IC 90%: 1,82;4,25 maiores do que entre os eutróficos. Entre os que praticavam atividade física regular, comparado aos que não praticavam, a prevalência foi 52% menor (IC 90%: 0,30;0,90. CONCLUSÕES: Ser ex-fumante e ter sobrepeso ou obesidade foram situações de risco para hipertensão, enquanto que a prática regular de atividade física foi fator de proteção em militares jovens.OBJETIVO: Estimar la prevalencia de hipertensión arterial entre militares jóvenes y factores asociados. MÉTODOS: Estudio transversal realizado con muestra de 380 militares del sexo masculino de 19 y 35 años de edad en una unidad de la Fuerza Aérea Brasilera en la cuidad de São Paulo, Sudeste de Brasil, entre 2000 y 2001. Los puntos de corte para

  19. Factores psicosociales laborales relacionados con la tensión arterial y síntomas cardiovasculares en personal de enfermería en México Psychosocial work factors associated to blood pressure and cardiovascular symptoms among Mexican nurses

    OpenAIRE

    Arturo Juárez-García

    2007-01-01

    OBJETIVO: Determinar si la tensión laboral según el modelo de Karasek y la inseguridad en el empleo se asocian significativamente con indicadores cardiovasculares, tales como la tensión arterial (TA) y los síntomas cardiovasculares (SC), considerando factores tradicionales de riesgo cardiovascular (edad, índice de masa corporal, consumo de tabaco y alcohol, entre otros). MATERIAL Y MÉTODOS: En una muestra de 109 enfermeras de un hospital del sector público de la Ciudad de México durante el me...

  20. Surgarcane biopolymer patch in femoral artery angioplasty on dogs Membrana de biopolímero de cana-de-açúcar como remendo em arterioplastias femorais de cães

    Directory of Open Access Journals (Sweden)

    José Lamartine de Andrade Aguiar

    2007-01-01

    Full Text Available PURPOSE: The objective of this study was to evaluate the use of the sugarcane biopolymer membrane in femoral artery patch angioplasty on dogs. METHODS: Eight dogs were submitted to bilateral femoral artery patch angioplasty with a sugarcane biopolymer membrane patch on one side and e-PTFE patch on the contralateral side. This research was performed at Experimental Surgical Research Laboratory of the Centro de Ciências da Saúde at Universidade Federal de Pernambuco. The dogs were submitted to a new surgery at 180 days after the patch angioplasty in order to harvest the femoral artery. All the animals were evaluated by: clinical examination, measure of femoral artery diameter, arteriogram and Doppler fluxometry. Yet the material harvested was sent to histological study. Each animal served as its own control. RESULTS: In all vessels of both groups there were no cases of infection, aneurysm formation, rupture or pseudoaneurysm formation and thrombosis. In both groups it was observed a chronic inflammatory reaction with lymphocytes, neutrophils and fibrosis in the outer surface of the patches. It was observed fibrosis in the inner surfaces of all the patches. In e-PTFE patches occurred invasion by fibroblasts. CONCLUSION: The sugarcane biopolymer membrane can be used as a patch in femoral artery angioplasty on dogs.OBJETIVO: Avaliar a utilização da membrana do biopolímero de cana-de-açúcar quando utilizada como remendo em arterioplastias femorais de cães. MÉTODOS: Oito cães foram submetidos a arterioplastia femoral bilateral com enxertos em remendo com a membrana do biopolímero de cana-de-açúcar em um lado e com a prótese de e-PTFE no lado contra-lateral. Os experimentos foram realizados no Núcleo de Cirurgia Experimental do Centro de Ciências da Saúde da Universidade Federal de Pernambuco. A avaliação dos animais foi realizada através do exame clínico, da medida do diâmetro das artérias femorais, da fluxometria Doppler, da

  1. La estética y la diversión como factores generadores de valor en la experiencia de consumo en servicios

    Directory of Open Access Journals (Sweden)

    Raquel Sánchez Fernández

    2009-08-01

    Full Text Available En los últimos años, tanto académicos como profesionales del marketing han puesto en evidencia la importancia y el interés que supone la creación de valor en la experiencia de consumo en servicios, configurándose como fuente de ventaja competitiva. La mayoría de los trabajos empíricos desarrollados se han centrado en la generación de valor a través de elementos funcionales y utilitaristas, tales como la calidad y el precio. Más allá de estos, comienzan a investigarse algunos aspectos ambientales de carácter emocional o hedonista que también contribuyen a la creación de valor para el consumidor, como han puesto de manifiesto algunos trabajos recientes. En el presente estudio se profundiza en este campo, demostrando la importancia de los elementos hedonistas de estética y diversión, asociados a la atmósfera del establecimiento, como factores generadores de valor en la experiencia de consumo en servicios. A través del planteamiento de un modelo de ecuaciones estructurales, se desarrolla y valida una escala de valor hedonista, y se analiza en qué medida contribuye a la formación de otras variables ya relacionadas anteriormente con la creación de valor funcional, como son la satisfacción y la lealtad del consumidor.

  2. Positive Family History as the Single Traditional Risk Factor for Developing Extensive Very Premature Coronary Artery Disease: A Case Report

    Science.gov (United States)

    Ahmadi, Seyed Hossein; Abbasi, Seyed Hesameddin; Ugurlucan, Murat; Bina, Payvand

    2013-01-01

    Although coronary artery disease (CAD) is not common among individuals younger than 40–45 years of age, a small percentage of this age group needs to undergo surgical revascularization because of CAD. Why some people are at higher risk of developing premature CAD is not clearly known. Increased number of traditional risk factors or genetic predisposition may play significant roles in this regard. A 22-year-old man with a negative history for all traditional risk factors except for a family history of premature CAD referred to our center due to an episode of myocardial infarction of one month’s duration. He had no congenital heart disease and no hypercoagulable state, and there was a negative history of drug abuse. His coronary angiography showed extensive CAD. He underwent coronary artery bypass grafting and he left the hospital in good healthy condition. One year after surgery, his follow-up showed that he was symptom free and he still had no new traditional risk factor. It seems that a positive family history of premature CAD is an important and independent risk factor for developing premature CAD and individuals with this type of history should be treated more cautiously. PMID:23646049

  3. Hypoxia-inducible factor-1 alpha regulates the role of vascular endothelial growth factor on pulmonary arteries of rats with hypoxia-induced pulmonary hypertension

    Institute of Scientific and Technical Information of China (English)

    李启芳; 戴爱国

    2004-01-01

    Background Hypoxia-inducible factor-1α (HIF-1α) is one of the pivotal mediators in the response of lungs to decreased oxygen availability, and increasingly has been implicated in the pathogenesis of pulmonary hypertension. Vascular endothelial growth factor (VEGF), a downstream target gene of HIF-1α, plays an important role in the pathogenesis of hypoxic pulmonary hypertension and hypoxic pulmonary artery remodelling. In this study, we investigated the dynamic expression of HIF-1α and VEGF in pulmonary artery of rats with hypoxia-induced pulmonary hypertension. Methods Forty male Wistar rats were exposed to hypoxia for 0, 3, 7, 14 or 21 days. Mean pulmonary arterial pressure (mPAP), vessel morphometry and right ventricle hypertrophy index (RVHI) were estimated. Lungs were inflated and fixed for in situ hybridisation and immunohistochemistry. Results mPAP values were significantly higher than the control values after 7days of hypoxia [(18.4±0.4) mmHg, P<0.05]. RVHI developed significantly after 14 days of hypoxia. Expression of HIF-1α protein increased in pulmonary arterial tunica intima of all hypoxic rats. In pulmonary arterial tunica media, HIF-1α protein was markedly increased by day 3 (0.20±0.02, P<0.05), reached the peak by day 7, then declined after day 14 of hypoxia. HIF-1α mRNA increased significantly after day 14 of hypoxia (0.20±0.02, P<0.05). VEGF protein began to increase markedly after day 7 of hypoxia, reaching its peak around day 14 of hypoxia (0.15±0.02, P<0.05). VEGF mRNA began to increase after day 7 of hypoxia, then remained more or less stable from day 7 onwards. VEGF mRNA is located mainly in tunica intima and tunica media, whereas VEGF protein is located predominantly in tunica intima. Linear analysis showed that HIF-1α mRNA, VEGF and mPAP were correlated with hypoxic pulmonary artery remodelling. HIF-1α mRNA was positively correlated with VEGF mRNA and protein (P<0.01). Conclusion HIF-1α and VEGF are both involved in the

  4. Prevalencia y factores asociados a la hipertensión arterial en menores de 19 años. Municipio Matanzas. 2010 Prevalence and factors associated to the arterial hypertension in persons younger than 19 years old. Municipality of Matanzas. 2010

    Directory of Open Access Journals (Sweden)

    Julio Martínez García

    2012-12-01

    Full Text Available Se realizó un estudio epidemiológico observacional, analítico de tipo transversal (prevalencia, para identificar la prevalencia y los factores asociados a la hipertensión arterial en menores de 19 años, en el municipio de Matanzas, en el año 2010. El universo estuvo constituido por todos los menores de 19 años pertenecientes al mencionado municipio, residentes en zona urbana y matriculados en los diferentes niveles de enseñanza del sistema de educación, los cuales representan un total de 19 756. La muestra quedó conformada por 892 personas, a las cuales se le aplicó un cuestionario. Los datos obtenidos fueron procesados en el programa EpiInfo 3.4.3 2007. Para el análisis de los datos se emplearon medidas de frecuencias absolutas y relativas; se utilizó el enfoque de riesgo en el análisis bivariado, con cálculo de Odds Ratio (OR con sus intervalos de confianza (IC, considerándose significativo cuando no incluyera el valor 1, y el valor de p fuera menor de 0,05. Además, se calculó el riesgo atribuible en aquellas en el que el análisis bivariado fueron significativas. Las 8 variables que resultaron significativas en el análisis bivariado, al analizarlas en el multivariado, se mostraron como verdaderos factores asociados al hipertenso en la edad pediátrica mediante el modelo de regresión logística: El antecedente patológico familiar de hipertensión arterial, el estado nutricional (obeso y sobrepeso, las glomerulopatías, la sepsis urinaria a repetición y las uropatías obstructivas, además de la cefalea y la epistaxis se hallaron como síntomas asociados a la hipertensión arterial en la edad pediátrica.We carried out an observational, epidemiologic, analytic-transversal study (prevalence to identify the prevalence and the factors associated to hypertension in persons aged less than 19 years old, in the municipality of Matanzas, in 2010. The universe was formed by all the patients aged less than 19 years old living in the

  5. A instituição asilar como fator potencializador da disfagia The asylum as worsening factor for dysphagia

    Directory of Open Access Journals (Sweden)

    Ana Maria Furkim

    2010-12-01

    Full Text Available OBJETIVO: verificar se as condições referentes à estrutura geral dos asilos, recursos humanos e rotinas diárias de alimentação em instituições asilares, podem potencializar alterações da dinâmica da deglutição em idosos. MÉTODOS: foi aplicado questionário aos dirigentes de cinco instituições asilares do município do Rio de Janeiro, no qual constavam perguntas em relação aos recursos materiais, humanos e rotina alimentar. RESULTADOS: o asilo do sistema privado foi o único a aproximar-se das condições ideais da estrutura geral para o atendimento do idoso. Em relação aos recursos humanos existentes, nenhum dos asilos possuía todos os profissionais exigidos pela portaria nº810/89. Em relação às rotinas diárias de alimentação, em uma das instituições pesquisadas, cuja maioria dos residentes não faziam uso de próteses dentárias, não havia restrição na consistência alimentar oferecida. Outro fator significativo diz respeito à negligência referente à higiene bucal, favorecendo a colonização de bactérias na cavidade oral, podendo agravar infecções pulmonares no caso de microaspirações. O fato dos idosos deitarem para dormir logo após o término das refeições, como ocorrido em três das instituições pesquisadas, tem grande importância na medida em que favorece a ocorrência de episódios de refluxo gastroesofágico. CONCLUSÃO: foram observados que em todas as instituições pesquisadas há fatores que podem potencializar um distúrbio de deglutição, como problemas em relação à estrutura geral e ou aos recursos humanos e ou relativos à rotina alimentar estabelecida.PURPOSE: to check if the conditions related to general structure, human resources and daily routine of feeding in asylums can increase the chances for an alteration in the deglutition process of the elderlies. METHODS: a questionnaire was elaborated to be applied to the directors of five institutions in the city of Rio de Janeiro

  6. Carotid artery disease in cerebrovasculas asymptomatic volunteerscorrelations with risk factors, CBF and CT findings

    International Nuclear Information System (INIS)

    In an effort to determine the prevalence of carotid artery disease in cerebrovascular asymptomatic volunteers, 125 randomly chosen active and retired employees of the state of Styria, Austria (82 men, 43 women, age 24 - 75, mean 49.6 +/- 10.5 years) were examined. High resolution Duplex-scanning reveales minimal to mild atherosclerotic plaques (<50% diameter stenosis), predominantly in the carotid bifurcation in 37/125 cases (29.6%). When controlling for age and sex, the incidences of hypertension, diabeter mallitus, cardiac disorders, peripheral vascular disease, cigarette smoking and elevated serum cholesterol were not significally different in the sonographycally affected and not affected group. Besides age (p=0.0002) to be significant predictors of the presence of asymptomatic atherosclerotic carotid artery disease. (author). 7 refs.; 2 tabs

  7. Preeclampsia como factor de riesgo independiente para el trastorno por déficit de atención con hiperactividad. Estudio de casos y controles. Bucaramanga, Colombia

    OpenAIRE

    Yuly Andrea Castellanos-Castellanos; Mauricio Escobar-Sánchez; María Carolina Páez-Leal; Luis Alfonso Díaz-Martínez; Carlos Andrés Arias-Duran; Derlly Marcela Espitia-Orejarena; Jesica Lisette Forero-Parada

    2014-01-01

    Introducción: El trastorno por déficit de atención e hiperactividad es una condición mental que afecta a niños y adolescentes con prevalencia estimada de 5.3% en la población mundial y en Colombia es de 19-24% en hombres y 10-12% en mujeres. Su etiología es multifactorial, entre ellos se encuentra la hipoxia como factor del medio ambiente uterino; presentándose en entidades como la preeclampsia, donde se ha considerado determinante en el desarrollo del trastorno por dé...

  8. Acute Myocardial Infarction Is a Risk Factor for New Onset Diabetes in Patients with Coronary Artery Disease

    OpenAIRE

    Chul Soo Park; Woo Baek Chung; Yun Seok Choi; Pum Joon Kim; Jong Min Lee; Ki-Hyun Baek; Hee Yeol Kim; Ki Dong Yoo; Ki-Ho Song; Wook Sung Chung; Ki Bae Seung; Man Young Lee; Hyuk-Sang Kwon

    2015-01-01

    Objective To test the hypothesis that acute myocardial infarction (AMI) might accelerate development of new onset diabetes in patients with coronary artery disease independent of known risk factors. Methods We conducted a retrospective cohort study within COACT (CathOlic medical center percutAneous Coronary inTervention) registry. From a total of 9,127 subjects, 2,036 subjects were diabetes naïve and followed up for at least one year with both index and follow-up laboratory data about diabete...

  9. The Effect of PAI-1 4G/5G Polymorphism and Clinical Factors on Coronary Artery Occlusion in Myocardial Infarction

    OpenAIRE

    Tajinder Kumar Parpugga; Vacis Tatarunas; Vilius Skipskis; Nora Kupstyte; Diana Zaliaduonyte-Peksiene; Vaiva Lesauskaite

    2015-01-01

    Objective. Data on the impact of PAI-1-675 4G/5G genotype for fibrinolysis during myocardial infarction are inconsistent. The aim of our study was to evaluate the association of clinical and genetic (PAI-1-675 4G/5G polymorphism) factors with coronary artery occlusion in patients with myocardial infarction. Materials and Methods. PAI-1-675 4G/5G detection was achieved by using Sanger sequencing in a sample of patients hospitalized for stent implantation due to myocardial infarction. We catego...

  10. Factors Associated with Early Adverse Events after Coronary Artery Bypass Grafting Subsequent to Percutaneous Coronary Intervention

    OpenAIRE

    Kamal, Yasser Ali; Mubarak, Yasser Shaban; Alshorbagy, Ashraf Ali

    2016-01-01

    Background A previous percutaneous coronary intervention (PCI) may affect the outcomes of patients who undergo coronary artery bypass grafting (CABG). The objective of this study was to compare the early in-hospital postoperative outcomes between patients who underwent CABG with or without previous PCI. Methods The present study included 160 patients who underwent isolated elective on-pump CABG at the department of cardiothoracic surgery, Minia University Hospital from January 2010 to Decembe...

  11. Effects of CPAP on "vascular" risk factors in patients with obstructive sleep apnea and arterial hypertension

    Directory of Open Access Journals (Sweden)

    Litvin AY

    2013-05-01

    Full Text Available AY Litvin,1 ZN Sukmarova,1 EM Elfimova,1 AV Aksenova,1 PV Galitsin,1 AN Rogoza,2 IE Chazova11Department of Systemic Hypertension, 2Department of New Methods of Diagnostics, Russian Cardiology Research and Production Complex, Ministry of Health, Moscow, Russian FederationBackground: The aim of this study was to assess the effects of continuous positive airway pressure (CPAP on arterial stiffness, central blood pressure, and reflected pulse wave characteristics in patients with severe obstructive sleep apnea (OSA and stage 2–3 arterial hypertension.Methods: Forty-four patients with hypertension and severe OSA (apnea/hypopnea index > 30 received stepped dose titration of antihypertensive treatment, consisting of valsartan 160 mg + amlodipine 5–10 mg + hydrochlorothiazide 25 mg. CPAP therapy was added after 3 weeks of continuous antihypertensive treatment with BP 12 msec persisted in 35% of patients on antihypertensive treatment and effective CPAP, in 56% of patients on antihypertensive treatment alone, and in 53% of patients on placebo CPAP. Only the combination of antihypertensive treatment with effective CPAP achieved a significant reduction in augmentation index and AASI, along with a further reduction in aortic and brachial BP.Conclusion: Effective CPAP for 3 weeks resulted in a significant additional decrease in office BP, ambulatory BP monitoring, central BP, and augmentation index, together with an improvement in arterial stiffness parameters, ie, cfPWV and AASI, in a group of hypertensive patients with OSA.Keywords: antihypertensive therapy, hypertension, obstructive sleep apnea, continuous positive airway pressure, blood pressure, arterial stiffness, pulse wave velocity

  12. Atherosclerosis of Coronary Arteries as Predisposing Factor in Myocardial Infarction: An Autopsy Study

    OpenAIRE

    Gauravi A Dhruva,; Amit H Agravat; Hardik K Sanghvi

    2012-01-01

    The incidence of coronary heart disease has markedly increased in India over the past few years. Ischemic heart disease, the largest cause of morbidity and mortality in the developed and developing countries today is overwhelmingly contributed by atherosclerosis. The study highlights the impact of atherosclerotic lesions in the population of Rajkot district. We studied atherosclerotic lesions in coronary arteries in cases subjected to autopsy in last 4 years, to grade and to evaluate the athe...

  13. Doppler Sonography Confirmation in Patients Showing Calcified Carotid Artery Atheroma in Panoramic Radiography and Evaluation of Related Risk Factors

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    Mahrokh Imanimoghaddam

    2012-02-01

    Full Text Available Background and aims. The purpose of this study was to identify patients at the risk of cerebrovascular attack (CVA by detecting calcified carotid artery atheroma (CCAA in panoramic radiography and evaluating their risk factors. Materials and methods. A total of 960 panoramic radiographs of patients above 40 years old were evaluated. Doppler Sonography (DS was performed for patients who showed calcified carotid artery atheroma (CCAA in panoramic radiography in order to determine the presence of CCAA and the degree of stenosis. Cardiovascular risk factors in both groups of patients with CCAA (12 subjects and without CCAA (3 subjects were compared using a questionnaire filled out by the patients. Statistical analysis including Fisher and independent t-test applied for data analysis. Results. Fifteen patients (30 sides showed calcification in their panoramic radiographs, and underwent DS which revealed CCAA in 16 sides (12 patients. Two patients (13.33% showed stenosis greater than 70%. Among the risk factors, only age showed a significant association with the occurrence of carotid calcified atheroma (P=0.026. Conclusion. Considering the results, dentists should refer especially elderly patients with radiographically identified atheromas for further examinations, as asymptomatic CCAA might be associated with high degrees of stenosis.

  14. Doppler Sonography Confirmation in Patients Showing Calcified Carotid Artery Atheroma in Panoramic Radiography and Evaluation of Related Risk Factors

    Science.gov (United States)

    Imanimoghaddam, Mahrokh; Rah Rooh, Mohammad; Mahmoudi Hashemi, Elahe; Javadzade Blouri, Abbas

    2012-01-01

    Background and aims The purpose of this study was to identify patients at the risk of cerebrovascular attack (CVA) by detecting calcified carotid artery atheroma (CCAA) in panoramic radiography and evaluating their risk factors. Materials and methods A total of 960 panoramic radiographs of patients above 40 years old were evaluated. Doppler Sonography (DS) was performed for patients who showed calcified carotid artery atheroma (CCAA) in panoramic radiogra-phy in order to determine the presence of CCAA and the degree of stenosis. Cardiovascular risk factors in both groups of patients with CCAA (12 subjects) and without CCAA (3 subjects) were compared using a questionnaire filled out by the patients. Statistical analysis including Fisher and independent t-test applied for data analysis. Results Fifteen patients (30 sides) showed calcification in their panoramic radiographs, and underwent DS which revealed CCAA in 16 sides (12 patients). Two patients (13.33%) showed stenosis greater than 70%. Among the risk factors, only age showed a significant association with the occurrence of carotid calcified atheroma (P=0.026). Conclusion Considering the results, dentists should refer especially elderly patients with radiographically identified atheromas for further examinations, as asymptomatic CCAA might be associated with high degrees of stenosis. PMID:22991627

  15. Factores associados à hipertensão arterial nos utentes de farmácias em Portugal Factores asociados con la hipertensión arterial en los usuarios de farmacias en Portugal Factors associated with arterial hypertension in pharmacy users in Portugal

    Directory of Open Access Journals (Sweden)

    Sofia de Oliveira-Martins

    2011-02-01

    Full Text Available OBJETIVO: Estimar a prevalência, tratamento e controlo da hipertensão e identificar factores associados em utentes de farmácias comunitárias. MÉTODOS: Estudo transversal com 1.042 utentes de 40 a 65 anos em 60 farmácias comunitárias de Portugal Continental entre outubro de 2005 e janeiro de 2006. Os dados foram obtidos pela aplicação de questionário e medição de parâmetros biológicos. Foram realizadas três regressões logísticas sequenciais para verificar associação entre as variáveis. RESULTADOS: A idade média foi de 53,7 anos e a razão homem/mulher foi 0,68. A prevalência da hipertensão arterial foi de 54,8%. Cerca de 70% dos hipertensos encontravam-se sob tratamento anti-hipertensivo e, destes, 47,7% estavam controlados. A hipertensão esteve positivamente associada à idade mais elevada, sexo masculino, ser casado, apresentar índice de massa corporal e nível de colesterol total mais alto, ser diabético, ter doença cardiovascular pessoal ou familiar precoce e reportar mais consultas médicas por ano. A hipertensão tratada mostrou-se positivamente associada a ser mulher, não casado, ser diabético, viver numa área urbana e reportar mais de três consultas médicas por ano. Nos hipertensos tratados, estar controlado foi positivamente associado a ter comportamento aderente à terapêutica anti-hipertensiva (auto-reporte, percepcionar o efeito desta medicação e ser de baixo risco cardiovascular. Os modelos preditivos apresentaram áreas sob as respectivas curvas ROC entre 0,72 e 0,78, com capacidade discriminatória aceitável. CONCLUSÕES: A prevalência da hipertensão foi elevada, mas similar à encontrada em outros estudos realizados em Portugal. A proporção de doentes tratados foi satisfatória, em contraste com o nível insuficiente de controlo.OBJETIVO: Estimar la prevalencia de la hipertensión, tratamiento y control, así como identificar factores asociados en usuarios de farmacias comunitarias. M

  16. FACTORES ASOCIADOS CON EL DESEMPEÑO DEL PERSONAL QUE LABORA COMO OFICIALES DE TRÁNSITO Y SEGURIDAD EN LA UNIVERSIDAD DE COSTA RICA

    Directory of Open Access Journals (Sweden)

    Ernestina Aguirre Vidaurre

    2012-04-01

    Full Text Available El objetivo de este artículo es presentar los resultados de la investigación Factores que afectan el desempeño laboral de los y las oficiales de Tránsito y Seguridad, llevada a cabo en la Sede Ciudad Universitaria Rodrigo Facio de la Universidad de Costa Rica, durante el primer semestre del año 2009. La población estuvo conformada por 57 oficiales de tránsito y seguridad. Se aplicó un diseño cuantitativo de tipo descriptivo. Los instrumentos utilizados fueron la guía de observación y el cuestionario, los cuales fueron validados previamente. Los aspectos por analizar fueron las incapacidades, factores de riesgo que generan incapacitaciones, así como aquellos eventos que dañen el bienestar del trabajador; también, se emplearon resultados que proporcionó el Diagnóstico de Atención Primaria Ambiental (APA. Este estudio evidenció una alta incidencia de enfermedades crónicas que empeoran al exponerse a factores propios del trabajo, así como por la práctica de inadecuados estilos de vida como el tabaquismo, una mala alimentación y el sedentarismo. Del mismo modo, se presentan factores protectores como alto grado de satisfacción laboral, adecuadas relaciones interpersonales, conocimiento de los derechos y deberes laborales. Existen factores de riesgo como el grupo etáreo, jornadas laborales excesivas, horarios rotativos, así como alta movilidad por el campus. Como principal hallazgo se encontró que las causas más frecuentes de incapacidad laboral son las caídas y la gripe. Se concluye que los beneficios de un ambiente de trabajo saludable no se reducen al fortalecimiento de la salud del trabajador (a, sino a brindar un aporte positivo a la productividad e incrementar la motivación laboral, el espíritu de trabajo, la satisfacción en el trabajo y la calidad de vida general, aspectos que forman parte del objetivo de la práctica de la enfermera (o en estos espacios.

  17. RELATIONSHIP OF CAROTID ARTERIES INTIMA-MEDIA THICKNESS WITH INFECTIOUS, IMMUNE, METABOLIC FACTORS AND INFLAMMATION MARKERS IN HEALTHY PERSONS

    Directory of Open Access Journals (Sweden)

    A. P. Shavrin

    2014-07-01

    Full Text Available Aim – to examine the relationship of arteries wall thickness with the indicators characterizing the infectious, immune, metabolic status inapparently healthy individuals.Materials and methods. The study included 342 patients (mean age 43.7 ± 0.5 years that in the process of cluster analysis on the thicknessof the intima-media thickness (IMT were divided into 3 groups. Group 1 consisted of patients with no risk factors of cardiovascular disease,2nd – patients with presence of these factors, 3rd – patients with atherosclerotic plaques in the carotid artery. All patients were examinedin complex: ultrasound of vessels measurement on the Aloka 5000 with IMT, evaluation of lipid profile, glucose level, determination of C-reactive protein (CRP in blood plasma and cytokines – tumor necrosis factor-α (TNF-α, interferon-γ (IFN-γ, interleukin (IL -1, -8, -4, specific antibody immunoglobulin G (IgG to cytomegalovirus (CMV, herpes simplex virus type 1 (HSV-1 , C. pneumoniae, H. pylori and β-hemolytic streptococci group A. Immune system status was assessed by innate and acquired immunity factors.Results. In groups of examined patients by increasing IMT of the common carotid artery infectious viruses (CMV, HSV-1 burden increased,what was obligatory for all groups. In the 3rd group, in 45 % of patients C. pneumoniae was found. In the 2nd and 3rd groups weakening ofacquired immunity was found out – reducing the total number of lymphocytes and T-lymphocytes, the increase of CRP and proinflammatory cytokines (IL-1, -8, IFN-γ, TNF-α, it was indicating development of inflammatory process, and in the third group it took characters of the system inflammatory response. In cluster analysis it was revealed that the process of thickening of the vascular wall is influenced by complex factors – infectious, metabolic and immune.Conclusion. The presence of the close relationship between the thickness of vessel walls and infectious, metabolic (lipid and

  18. RELATIONSHIP OF CAROTID ARTERIES INTIMA-MEDIA THICKNESS WITH INFECTIOUS, IMMUNE, METABOLIC FACTORS AND INFLAMMATION MARKERS IN HEALTHY PERSONS

    Directory of Open Access Journals (Sweden)

    A. P. Shavrin

    2011-01-01

    Full Text Available Aim – to examine the relationship of arteries wall thickness with the indicators characterizing the infectious, immune, metabolic status inapparently healthy individuals.Materials and methods. The study included 342 patients (mean age 43.7 ± 0.5 years that in the process of cluster analysis on the thicknessof the intima-media thickness (IMT were divided into 3 groups. Group 1 consisted of patients with no risk factors of cardiovascular disease,2nd – patients with presence of these factors, 3rd – patients with atherosclerotic plaques in the carotid artery. All patients were examinedin complex: ultrasound of vessels measurement on the Aloka 5000 with IMT, evaluation of lipid profile, glucose level, determination of C-reactive protein (CRP in blood plasma and cytokines – tumor necrosis factor-α (TNF-α, interferon-γ (IFN-γ, interleukin (IL -1, -8, -4, specific antibody immunoglobulin G (IgG to cytomegalovirus (CMV, herpes simplex virus type 1 (HSV-1 , C. pneumoniae, H. pylori and β-hemolytic streptococci group A. Immune system status was assessed by innate and acquired immunity factors.Results. In groups of examined patients by increasing IMT of the common carotid artery infectious viruses (CMV, HSV-1 burden increased,what was obligatory for all groups. In the 3rd group, in 45 % of patients C. pneumoniae was found. In the 2nd and 3rd groups weakening ofacquired immunity was found out – reducing the total number of lymphocytes and T-lymphocytes, the increase of CRP and proinflammatory cytokines (IL-1, -8, IFN-γ, TNF-α, it was indicating development of inflammatory process, and in the third group it took characters of the system inflammatory response. In cluster analysis it was revealed that the process of thickening of the vascular wall is influenced by complex factors – infectious, metabolic and immune.Conclusion. The presence of the close relationship between the thickness of vessel walls and infectious, metabolic (lipid and

  19. Síndrome de Apnea Obstructiva del Sueño como factor de riesgo para otras enfermedades

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    Héctor Guzmán Duchén

    2011-06-01

    Full Text Available El síndrome de apnea obstructiva del sueño es una enfermedad caracterizada por ciclos de apneas e hipopneas y microdespertares frecuentes durante la noche y así mismo hipersomnolencia diurna. Esta enfermedad conlleva altas incidencias en accidentes de tránsito como en el campo laboral, últimos estudios de esta patología seacompaña de complicaciones y desarrollo de diversas enfermedades tanto cardiovasculares como metabólicas y oftalmológicas entre otras.

  20. Síndrome de Apnea Obstructiva del Sueño como factor de riesgo para otras enfermedades

    OpenAIRE

    Héctor Guzmán Duchén; Yblin Katherine Virhuez Salguero; Reynaldo Araoz Illanes

    2011-01-01

    El síndrome de apnea obstructiva del sueño es una enfermedad caracterizada por ciclos de apneas e hipopneas y microdespertares frecuentes durante la noche y así mismo hipersomnolencia diurna. Esta enfermedad conlleva altas incidencias en accidentes de tránsito como en el campo laboral, últimos estudios de esta patología seacompaña de complicaciones y desarrollo de diversas enfermedades tanto cardiovasculares como metabólicas y oftalmológicas entre otras.

  1. Circulating Thrombotic Risk Factors in Young Patients with Coronary Artery Disease Who Are on Statins and Anti-platelet Drugs.

    Science.gov (United States)

    George, Reema; Sivadasanpillai, Harikrishnan; Jayakumari, Narayani; Bhatt, Anugya; Thulaseedharan, Jissa V; Tharakan, Jaganmohan A

    2016-07-01

    Thrombotic risk factors may contribute to premature coronary artery disease (CAD), in addition to the conventional risk factors. There is paucity of data on studies evaluating the role of thrombotic factors in premature CAD in Indian patients. Thus a case-control study was performed to evaluate the role of thrombotic and atherogenic factors in young patients with angiographically proven CAD who are on treatment with statins and anti-platelet drugs. 152 patients (≤55 years) with angiographically proven CAD and 102 asymptomatic controls were recruited. Clinical and biochemical data were obtained in both groups. Blood levels of thrombotic factors-fibrinogen, antithrombin-III, tissue-plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), von-Willebrand factor (v-WF), lipoprotein(a) [Lp(a)] and homocysteine were analyzed. Patients had high levels of conventional CAD risk factors (diabetes mellitus, smoking, hypertension, dyslipidemia and positive family history) compared to controls. Logistic regression analysis revealed that low antithrombin-III (odds ratio/OR 11.2; 95 % confidence interval/CI 2.29-54.01), high fibrinogen (OR 6.04; 95 % CI 1.09-33.21) and high Lp(a) (OR 4.54; 95 % CI 0.92-22.56), as important, independent risk factors in patients. PAI-1(OR 0.15; 95 % CI 0.03-0.69) levels were significantly lower in patients. But other thrombotic risk factors studied (t-PA, v-WF and homocysteine) were comparable among patients and controls. The treatment using statins and anti-platelet drugs might be contributing to the control of some of the thrombotic risk factors. The strategies aiming at lowering the levels of thrombotic risk factors along with conventional risk factors may be useful in primary and secondary prevention of CAD. PMID:27382201

  2. Clinical factors related to recurrence after hepatic arterial concurrent chemoradiotherapy for advanced but liver-confined hepatocellular carcinoma

    International Nuclear Information System (INIS)

    Before the sorafenib era, advanced but liver-confined hepatocellular carcinoma (HCC) was treated by liver-directed therapy. Hepatic arterial concurrent chemoradiotherapy (CCRT) has been performed in our group, giving substantial local control but frequent failure. The aim of this study was to analyze patterns of failure and find out predictive clinical factors in HCC treated with a liver-directed therapy, CCRT. A retrospective analysis was done for 138 HCC patients treated with CCRT between May 2001 and November 2009. Protocol-based CCRT was performed with local radiotherapy (RT) and concurrent 5-fluorouracil (5-FU) hepatic arterial infusion chemotherapy (HAIC), followed by monthly HAIC (5-FU and cisplatin). Patterns of failure were categorized into three groups: infield, intrahepatic-outfield and extrahepatic failure. Treatment failure occurred in 34.0% of patients at 3 months after RT. Infield, intrahepatic-outfield and extrahepatic failure were observed in 12 (8.6%), 26 (18.7%) and 27 (19.6%) patients, respectively. Median progression-free survival for infield, outfield and extrahepatic failure was 22.4, 18 and 21.5 months, respectively. For infield failure, a history of pre-CCRT treatment was a significant factor (P=0.020). Pre-CCRT levels of alpha-fetoprotein and prothrombin induced by vitamin K absence or antagonist-II were significant factors for extrahepatic failure (P=0.029). Treatment failures after CCRT were frequent in HCC patients, and were more commonly intrahepatic-outfield and extrahepatic failures than infield failure. A history of pre-CCRT treatment and levels of pre-CCRT tumor markers were identified as risk factors that could predict treatment failure. More intensified treatment is required for patients presenting risk factors. (author)

  3. Factores de riesgo como pron??stico de padecer c??ncer de mama en un estado de M??xico

    OpenAIRE

    Aguilar Cordero, Mar??a Jos??; Neri S??nchez, M.; Padilla L??pez, C. A.; Pimentel Ram??rez, M. L.; Garc??a Rillo, A.; S??nchez L??pez, A. M.

    2012-01-01

    Introducci??n: El c??ncer de mama es una de las patolog??a m??s frecuentes de la mujer y con gran impacto en la sociedad. Los factores de riesgo m??s estudiados han sido los hormonales, los gen??ticos y los ambientales, aunque tambi??n los h??bitos t??xicos, el sobrepeso y la obesidad; como factores protectores, por el contrario, la lactancia materna y la actividad f??sica. Objetivo: Conocer los factores de riesgo de las mujeres con c??ncer de mama en nuestro grupo de estudio. Material y m??t...

  4. Prevalencia de la hipertensión arterial y factores asociados en población adulta de la Comunitat Valenciana

    OpenAIRE

    Zubeldia Lauzurica, Lourdes

    2014-01-01

    La hipertensión es el principal factor de riesgo en términos de mortalidad atribuible y el principal factor de riesgo cardiovascular modificable. Los objetivos del estudio han sido: estimar la prevalencia de hipertensión arterial en población adulta de la Comunitat Valenciana, describir el grado de conocimiento, tratamiento y control de la hipertensión y la fuerza de asociación entre determinados factores y la presencia de hipertensión arterial. El punto de partida ha sido una submuestra d...

  5. Risk factors of arterial hypertension prevalence and incidence in the population living in the radionuclide contaminated territory

    International Nuclear Information System (INIS)

    Higher prevalence of hypertension among population in the radionuclide contaminated zones was positively associated with body mass index (P2 (P<0.001), alcohol abuse (P<0.01), gustatory sensitivity to sodium chloride (P<0.001), heart rate (P<0.001), smoking (P<0.01), sex (P<0.01), profession (P<0.05), total cholesterol (P<0.05). The hypertension incidence from associated risk factors was positively interacted with age (P<0.001), family history of premature cardiovascular disease (P<0.001), body mass index (P<0.001), alcohol abuse (P<0.001), heart rate (P<0.001), Cs 137 deposition density (P<0.05), gustatory sensitivity to sodium chloride (P<0.05), total cholesterol (P<0.05). The residence of people in the radionuclide contaminated zones is an independent risk factor of arterial hypertension

  6. La melatonina como un factor promotor de la diferenciación neuronal: implicaciones en el tratamiento de las demencias

    Directory of Open Access Journals (Sweden)

    Gloria Benítez-King

    2013-01-01

    Full Text Available Las demencias son enfermedades neuropsiquiátricas, progresivas, neurodegenerativas y con una alta prevalencia a nivel mundial. Ocu- pan uno de los primeros lugares como enfermedades que causan incapacidad en los adultos mayores. En estos pacientes el Sistema Nervioso Central presenta alteraciones anatómico-estructurales a ni- vel celular y subcelular que se asocian con deficiencias cognitivas. En particular, en la enfermedad de Alzheimer se han caracterizado mar- cadores histopatológicos como las placas amiloides y las marañas neurofibrilares. Se sabe que el estrés oxidativo y la neuroinflamación participan en la etiología y el desarrollo de la enfermedad. Reciente- mente se caracterizó a los precursores neuronales del neuroepitelio olfatorio humano como un modelo experimental adecuado para iden- tificar biomarcadores de rasgo y para estudiar la fisiopatología de diversas enfermedades neuropsiquiátricas, así como el proceso del neurodesarrollo, a nivel celular, molecular y farmacológico. En este trabajo se presenta la evidencia que sustenta que la melatonina puede ser útil en el tratamiento de las demencias, por su capacidad antioxi- dante, por su efecto anti-inflamatorio, así como por el efecto inhibidor de la hiperfosforilación de la proteina tau y de la formación de placas amiloides. Además, al estimular la formación de nuevas neuronas, la neuritogénesis en sus etapas tempranas y la formación de dendritas, la melatonina podría contribuir a contrarrestar la pérdida de las fun- ciones cognitivas que se observa en estos padecimientos.

  7. Atherosclerosis of Coronary Arteries as Predisposing Factor in Myocardial Infarction: An Autopsy Study

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    Gauravi A Dhruva,

    2012-10-01

    Full Text Available The incidence of coronary heart disease has markedly increased in India over the past few years. Ischemic heart disease, the largest cause of morbidity and mortality in the developed and developing countries today is overwhelmingly contributed by atherosclerosis. The study highlights the impact of atherosclerotic lesions in the population of Rajkot district. We studied atherosclerotic lesions in coronary arteries in cases subjected to autopsy in last 4 years, to grade and to evaluate the atheromatous plaques; and to assess the cases of myocardial infarction amongst them. The study comprises dissected specimens of heart in total 360 cases subjected for autopsy. The vessels were examined for the presence of atherosclerotic lesions which were graded according to American Heart Association and examined for evidence of myocardial infarction. The study comprises the cases in age group between 20 to 80 years. Commonest type of atherosclerosis seen was grade-4. Left Anterior Descending Coronary was most commonly involved artery. Myocardial infarction was the cause of death in 35 cases (9.72% The data obtained may form a baseline for the forthcoming studies.

  8. CARDIOVASCULAR RISK FACTORS AND IN-HOSPITAL MORTALITY IN 1258 CASES OF CORONARY ARTERY BYPASS SURGERY IN TEHRAN HEART CENTER

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    M H Mandegar

    2008-11-01

    Full Text Available "nCoronary artery bypass grafting (CABG surgery is being performed increasingly in Iran. So far, no large-scale report has described characteristics and risk factor profile and in-hospital mortality of patients undergoing this procedure in Iran. We conducted this study to address these topics in order to help clarify Iran's current state of CABG and to provide assistance in planning combat against coronary artery disease based on frequency of major risk factors. Patients who underwent isolated, first-time, elective, on-pump (conventional CABG in a cardiac surgery center in Tehran were prospectively studied from September 2004 and March 2005. Demographic data, risk factor profile and discharge status for each patient were recorded. There were 1258 patients, 937 men (74.5% and 321 women (25.5%. The mean age was 58.7 years (range 28 to 81; 133 patients (10.6% were 70 years old or older. Mean body mass index (BMI was 27.01 and 42.2% of the patients were smokers, 39.4% were hypertensive, and 27.6% had diabetes. Family history was positive in 40.3%. Congestive heart failure was found in 26.6%. New York Heart Association functional class III or IV was observed in 52.8% of patients. Single-vessel, two-vessel, and multi-vessel disease was found in 4.2%, 21.1%, and 74.7% of patients, respectively. Left main was involved in 9.8% and 14.4% had ejection fraction < 35%. The in-hospital mortality was 1.5%, mainly due to cardiac causes. This study indicates significant prevalence of major cardiovascular risk factors in Iranian CABG patients. In-hospital mortality of primary isolated CABG in Iran is similar to reported rates.

  9. Influential factors of clinical outcome of local intra-arterial thrombolysis using urokinase in patients with hyperacute ischemic stroke

    International Nuclear Information System (INIS)

    To evaluate the clinical outcome and other relevant factors in cases where local intra-arterial thrombolysis (LIT) is used for the treatment of hyperacute ischemic stroke. Forty-eight hyperacute ischemic stroke patients were treated by LIT, using urokinase, within six hours of ictus, and for evaluation of their neurological status, the national institutes of health stroke scale (NIHSS) score was used. Angiography recanalization was classified according to Mori recanalization grades. Three months after LIT, the outcome was assessed by clinical examination using the modified rankin scale (good outcome: RS=0-3; poor outcome: RS=4-6). In all patients, the findings of pre- and post- LIT CT, and angiography, as well as neurological status and hemorrhagic complications, were also analysed. Thirty-three patients had occlusions of the middle cerebral artery (MCA), and 15, of the internal carotid artery (ICA). The NIHSS score averaged 16.9 at the onset of therapy and 13.5 at 24 hours later. Successful recanalization (Mori grade 3,4) was achieved in 28 (58.3%) of 48 patients, but in 20 (41.7%) the attempt failed. Twenty-two (45.8%) of the 48 patients had a good outcome, but in (54.2%) the outcome was poor. Thirteen (40.6%) of 32 patients with MCA occlusions and 13 (81.2%) of 16 with ICA occlusions had a poor outcome. Eight patients (16.7%) died. Overall, hemorrhages occured in 20 (41.7%) of 48 patients, with symptomatic hemorrhage in ten. Five (50%) of these ten died. LIT using urokinase for hyperacute ischemic stroke is feasible; patients with MCA occlusions had better outcomes than those with ICA occlusions. Hemorrhagic complications of LIT were frequent, and in cases of symptomatic hemorrhage a fatal outcome may be expected

  10. Influential factors of clinical outcome of local intra-arterial thrombolysis using urokinase in patients with hyperacute ischemic stroke

    Energy Technology Data Exchange (ETDEWEB)

    Song, Jae Min; Yoon, Woong; Kim, Jae Kyu; Seo, Jeong Jin; Heo, Sook Hee; Park, Jin Gyoon; Jeong, Yoon Yeon; Kang, Heoung Keun [Chonam University Hospital, Kwangju (Korea, Republic of)

    2002-10-01

    To evaluate the clinical outcome and other relevant factors in cases where local intra-arterial thrombolysis (LIT) is used for the treatment of hyperacute ischemic stroke. Forty-eight hyperacute ischemic stroke patients were treated by LIT, using urokinase, within six hours of ictus, and for evaluation of their neurological status, the national institutes of health stroke scale (NIHSS) score was used. Angiography recanalization was classified according to Mori recanalization grades. Three months after LIT, the outcome was assessed by clinical examination using the modified rankin scale (good outcome: RS=0-3; poor outcome: RS=4-6). In all patients, the findings of pre- and post- LIT CT, and angiography, as well as neurological status and hemorrhagic complications, were also analysed. Thirty-three patients had occlusions of the middle cerebral artery (MCA), and 15, of the internal carotid artery (ICA). The NIHSS score averaged 16.9 at the onset of therapy and 13.5 at 24 hours later. Successful recanalization (Mori grade 3,4) was achieved in 28 (58.3%) of 48 patients, but in 20 (41.7%) the attempt failed. Twenty-two (45.8%) of the 48 patients had a good outcome, but in (54.2%) the outcome was poor. Thirteen (40.6%) of 32 patients with MCA occlusions and 13 (81.2%) of 16 with ICA occlusions had a poor outcome. Eight patients (16.7%) died. Overall, hemorrhages occured in 20 (41.7%) of 48 patients, with symptomatic hemorrhage in ten. Five (50%) of these ten died. LIT using urokinase for hyperacute ischemic stroke is feasible; patients with MCA occlusions had better outcomes than those with ICA occlusions. Hemorrhagic complications of LIT were frequent, and in cases of symptomatic hemorrhage a fatal outcome may be expected.

  11. Comparison of carotid artery intima - media thickness and risk factors of atherosclerosis in lacunar versus non-lacunar cerebral infarcts

    Directory of Open Access Journals (Sweden)

    Seyed Ali Mousavi

    2007-07-01

    Full Text Available

    BACKGROUND: Increases in the thickness of the intima-media of the carotid artery have been associated with an increased risk of myocardial infarction and stroke in subjects without a history of cardiovascular disease. Lacunar infarcts, one of the most common subtypes of ischemic stroke, show unique pathological and clinicoradiological characteristics. The present study examined the relationship between the vascular risk factors, including carotid artery intimamedia thickness (IMT, and lacunar versus non-lacunar infarcts.
    METHODS: We collected data from patients admitted to hospital with acute ischemic stroke. 195 Patients and 96 control subjects underwent B-mode ultrasonographic measurements of IMT of the common carotid artery. We examined the association of lacunar and non-lacunar infarcts with age, sex, and potential vascular risk factors.
    RESULTS: Of 195 adult patients with acute ischemic stroke, 87 were considered lacunar and 108 were considered nonlacunar strokes. Between these two groups of patients, we did not find a significantly different percentage of diabetes,
    smoking, hypertension, dyslipidemia, myocardial infarction, or previous history of ischemic stroke, alcohol, obesity,
    atherogen diet, exercise, and IMT. However, patients with lacunar infarct, diabetes mellitus (P = 0.02, and hypertension
    (P = 0.02 had a significantly higher percentage of history of prior CVA (P = 0.03 and a significantly higher percentage
    of non-lacunar infarct.
    CONCLUSIONS: The present results indicated that diabetes mellitus and hypertension are more common in patients with lacunar infarcts, and history of CVA is more common in patients with non–lacunar infarcts. We further concluded that IMT cannot differentiate subtypes of ischemic stroke. Because risk factors and clinical presentation of ischemic stroke differ among races, more national studies

  12. Predictive Factors for Delayed Extubation in the Intensive Care Unit after Coronary Artery Bypass Grafting; A Southern Iranian Experience

    Directory of Open Access Journals (Sweden)

    Shahrbanoo Shahbazi

    2012-12-01

    Full Text Available Background: Early extubation is implemented in cardiothoracic units worldwide for its advantages such as decreased mortality, morbidity, and hospitalization costs. We conducted a retrospective study to evaluate potential factors which may affect extubation time. Methods: The records of 334 eligible patients who underwent elective coronary artery bypass grafting (CABG in 2008 in Kowsar Hospital in Shiraz, southern Iran were evaluated to find the factors that can affect the extubation time. The patients were divided to early (equal or less than 6 hours and late extubation groups. The patients’ demographic data and operative variables were extracted from the records. We excluded patients with difficult intubation, severe acid base disturbance, neurological problems, and cardiovascular instability; and those who used intra-aortic balloon pump, had underwent emergency operation, or had another concomitant surgery. Results: Multiple logistic regressions comparing age, sex, number of grafts, ejection fraction, pump time, hematocrit, number of risk factors, and number of inotropic drugs, identified only age as a predictor of delayed extubation (odds ratio=1.07, CI 95%=1.04-1.10, P<0.001. Also, in both studied groups the men to women ratio was higher (P<0.05.Conclusion: Although in our study age was the only predictive factor for delayed extubation, a comprehensive study including preoperative, perioperative, and postoperative factors is recommended in our area.

  13. Hypoxia Induces Transforming Growth Factor-β1 Gene Expression in the Pulmonary Artery of Rats via Hypoxia-inducible Factor-1α

    Institute of Scientific and Technical Information of China (English)

    Yongliang JIANG; Aiguo DAI; Qifang LI; Ruicheng HU

    2007-01-01

    The present study was undertaken to investigate the dynamic expression of hypoxia inducible factor- 1 α (HIF-1 α) and transforming growth factor-β 1 (TGF-β 1) in hypoxia-induced pulmonary hypertension of rats. It was found that mean pulmonary arterial pressure (mPAP) increased significantly after 7 d of hypoxia. Pulmonary artery remodeling index and right ventricular hypertrophy became evident after 14 d of hypoxia. HIF-1α mRNA staining was less positive in the control, hypoxia for 3 d and hypoxia for 7 d, but began to enhance significantly after 14 d of hypoxia, then remained stable. Expression of HIF-1α protein in the control was less positive, but was up-regulated in pulmonary arterial tunica intima of all hypoxic rats.TGF-β1 mRNA expression in pulmonary arterial walls was increased significantly after 14 d of hypoxia, but showed no obvious changes after 3 or 7 d of hypoxia. In pulmonary tunica adventitia and tunica media,TGF-β1 protein staining was less positive in control rats, but was markedly enhanced after 3 d of hypoxia,reaching its peak after 7 d of hypoxia, and then weakening after 14 and 21 d of hypoxia. Western blotting showed that HIF-1α protein levels increased significantly after 7 d of hypoxia and then remained at a high level. TGF-βi protein level was markedly enhanced after 3 d of hypoxia, reaching its peak after 7 d of hypoxia, and then decreasing after 14 and 21 d of hypoxia. Linear correlation analysis showed that HIF-1αmRNA, TGF-β1 mRNA, TGF-β1 protein were positively correlated with mPAP, vessel morphometry and right ventricular hypertrophy index. TGF-β1 protein (tunica adventitia) was negatively correlated with HIF-1α mRNA. Taken together, our results suggest that changes in HIF-1α and TGF-β1 expression after hypoxia play an important role in hypoxia-induced pulmonary hypertension of rats.

  14. Experimental study on intra-arterial infusion of basic fibroblast growth factor in the ischemic limbs of rabbit model

    International Nuclear Information System (INIS)

    Objective: To evaluate the effect of intra-arterial infusion of basic fibroblast growth factor (bFGF) on improving neovascularization, vascular perfusion and the function of partially ischemic limbs of rabbits. Methods: Twenty-seven New Zealand male rabbits were selected. Partial ischemia model was induced by surgical ligation of the primary branches of right femoral artery in each animal, and the left hind limb of each animal was served as a nonischemic control. Then, 27 rabbits were randomly assigned to three groups: intra-arterial (IA) infusion of bFGF (n=9), intravenous (IV) infusion of bFGF and IA infusion of saline (n=9). Infusion was separately performed immediately after vascular ligation, 8th and 15th days post-surgery with 10 μg (4 ml) of bFGF per-time (or the same volume of saline). The differences between three groups and between ischemic and nonischemic limbs of the same group were compared and evaluated by the following indexes: (1) vessel section count (VSC), vessel section surface area (VSS) and vessel section perimeter (VSP) in the field of ischemic muscle tissues taken at 22nd day postoperatively; (2) capillary refilling time of ischemic limbs; and (3) functional and trophic changes of ischemic limbs. Statistical differences were evaluated by one-way ANOVA and T test. Results: VSC, VSS and VSP of the IA-bFGF group were significantly increased than those of the IV-bFGF and IA-saline groups (P<0.01). At 22nd day postoperatively, the capillary refilling time, new hair growth, the appearance and function of all ischemic limbs in IA-bFGF group were approximately normal. However, in IA-saline group, the ischemic changes, capillary refilling time and the function of ischemic limbs were not improved significantly. All the indexes of IV-bFGF group showed no difference statistically from those of IA-saline group. Conclusions: This experimental study identifies that intra-arterial infusion of bFGF may significantly promote neovascularization and vascular

  15. Factors influencing the renal arterial Doppler waveform: a simulation study using an electrical circuit model (secondary publication

    Directory of Open Access Journals (Sweden)

    Chang Kyu Sung

    2016-01-01

    Full Text Available Purpose: The goal of this study was to evaluate the effect of vascular compliance, resistance, and pulse rate on the resistive index (RI by using an electrical circuit model to simulate renal blood flow. Methods: In order to analyze the renal arterial Doppler waveform, we modeled the renal blood-flow circuit with an equivalent simple electrical circuit containing resistance, inductance, and capacitance. The relationships among the impedance, resistance, and compliance of the circuit were derived from well-known equations, including Kirchhoff’s current law for alternating current circuits. Simulated velocity-time profiles for pulsatile flow were generated using Mathematica (Wolfram Research and the influence of resistance, compliance, and pulse rate on waveforms and the RI was evaluated. Results: Resistance and compliance were found to alter the waveforms independently. The impedance of the circuit increased with increasing proximal compliance, proximal resistance, and distal resistance. The impedance decreased with increasing distal compliance. The RI of the circuit decreased with increasing proximal compliance and resistance. The RI increased with increasing distal compliance and resistance. No positive correlation between impedance and the RI was found. Pulse rate was found to be an extrinsic factor that also influenced the RI. Conclusion: This simulation study using an electrical circuit model led to a better understanding of the renal arterial Doppler waveform and the RI, which may be useful for interpreting Doppler findings in various clinical settings.

  16. A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Rui Liu

    2014-01-01

    Full Text Available Coronary artery disease is the leading cause of mortality and morbidity in the world. Left main coronary artery disease (LMCAD is a particularly severe phenotypic form of CAD and has a genetic basis. We hypothesized that some inflammation- and hyperhomocysteinemia-related gene polymorphisms may contribute to LMCAD susceptibility in a Chinese population. We studied the association between polymorphisms in the genes hepatocyte nuclear factor 1 alpha (HNF1A; rs7310409, G/A, C-reactive protein (rs1800947 and rs3093059 T/C, methylenetetrahydrofolate reductase (rs1801133, C/T, and methylenetetrahydrofolate dehydrogenase (rs1076991, A/G in 402 LMCAD and 804 more peripheral CAD patients in a Chinese population. Genotyping was performed using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry method. When the HNF1A rs7310409 GG homozygote genotype was used as the reference group, both the individual, GA and AA, and combined GA/AA genotypes were associated with an increased risk of LMCAD. This single nucleotide polymorphism (rs7310409 is strongly associated with plasma CRP levels. In conclusion, the present study provides evidence that the HNF1A rs7310409 G/A functional polymorphism may contribute to the risk of LMCAD.

  17. Brain-derived neurotrophic factor in arterial baroreceptor pathways: implications for activity-dependent plasticity at baroafferent synapses.

    Science.gov (United States)

    Martin, Jessica L; Jenkins, Victoria K; Hsieh, Hui-ya; Balkowiec, Agnieszka

    2009-01-01

    Functional characteristics of the arterial baroreceptor reflex change throughout ontogenesis, including perinatal adjustments of the reflex gain and adult resetting during hypertension. However, the cellular mechanisms that underlie these functional changes are not completely understood. Here, we provide evidence that brain-derived neurotrophic factor (BDNF), a neurotrophin with a well-established role in activity-dependent neuronal plasticity, is abundantly expressed in vivo by a large subset of developing and adult rat baroreceptor afferents. Immunoreactivity to BDNF is present in the cell bodies of baroafferent neurons in the nodose ganglion, their central projections in the solitary tract, and terminal-like structures in the lower brainstem nucleus tractus solitarius. Using ELISA in situ combined with electrical field stimulation, we show that native BDNF is released from cultured newborn nodose ganglion neurons in response to patterns that mimic the in vivo activity of baroreceptor afferents. In particular, high-frequency bursting patterns of baroreceptor firing, which are known to evoke plastic changes at baroreceptor synapses, are significantly more effective at releasing BDNF than tonic patterns of the same average frequency. Together, our study indicates that BDNF expressed by first-order baroreceptor neurons is a likely mediator of both developmental and post-developmental modifications at first-order synapses in arterial baroreceptor pathways. PMID:19054281

  18. Factors influencing the renal arterial Doppler waveform: a simulation study using an electrical circuit model (secondary publication)

    Energy Technology Data Exchange (ETDEWEB)

    Sung, Chang Kyu [Dept. of Radiology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul (Korea, Republic of); Han, Bong Soo [Dept. of Radiological Science, College of Health Science, Yonsei University, Wonju (Korea, Republic of); Kim, Seung Hyup [Dept. of Radiology, Institute of Radiation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2016-01-15

    The goal of this study was to evaluate the effect of vascular compliance, resistance, and pulse rate on the resistive index (RI) by using an electrical circuit model to simulate renal blood flow. In order to analyze the renal arterial Doppler waveform, we modeled the renal blood-flow circuit with an equivalent simple electrical circuit containing resistance, inductance, and capacitance. The relationships among the impedance, resistance, and compliance of the circuit were derived from well-known equations, including Kirchhoff’s current law for alternating current circuits. Simulated velocity-time profiles for pulsatile flow were generated using Mathematica (Wolfram Research) and the influence of resistance, compliance, and pulse rate on waveforms and the RI was evaluated. Resistance and compliance were found to alter the waveforms independently. The impedance of the circuit increased with increasing proximal compliance, proximal resistance, and distal resistance. The impedance decreased with increasing distal compliance. The RI of the circuit decreased with increasing proximal compliance and resistance. The RI increased with increasing distal compliance and resistance. No positive correlation between impedance and the RI was found. Pulse rate was found to be an extrinsic factor that also influenced the RI. This simulation study using an electrical circuit model led to a better understanding of the renal arterial Doppler waveform and the RI, which may be useful for interpreting Doppler findings in various clinical settings.

  19. Multivariate Analysis of Factors Influencing Length of Hospital Stay after Coronary Artery Bypass Surgery in Tehran, Iran

    Directory of Open Access Journals (Sweden)

    Amin Torabipour

    2016-03-01

    Full Text Available Length of hospital stay (LOS is a key indicator for hospital management. Reducing hospital stay is a priority for all health systems. We aimed to determine the length of hospital stay following Coronary Artery Bypass Surgery (CABG based on its clinical and non-clinical factors. A cross-sectional study of 649 consecutive patients who underwent coronary artery bypass graft surgery was conducted in Imam Khomeini and Shariati university hospitals, Tehran, Iran. Data was analyzed by using non-parametric univariate tests and multiple linier regression models. Thirty seven independent variables including pre-operative, intra-operative and post-operative variables were analyzed. Finally, an appropriate model was constructed based on the associated factors. The results showed that 70.3% of the patients were male, and the mean age of the patients was 59.3 ± 10.4 years. The Mean (±SD and median of the LOS were 11.7 ± 7.1 and 9 days, respectively. Of 37 investigated variables, 24 qualitative and quantitative variables were significantly associated with length of stay (p<0.05. Multiple linear regression analysis showed that independent variables including age, medical insurance type, body mass index, and prior myocardial infarction; admission day, admission season, Cross-clamp time, pump usage, admission type, the number of laboratory tests and the number of specialty consultation had more effect on the hospital stay. We concluded that some significant factors influencing hospital stay after CABG were predictable and modifiable by hospital managers and decision makers to manage hospital beds.

  20. Arterial Catheterization

    Science.gov (United States)

    ... version AMERICAN THORACIC SOCIETY Patient Information Series Arterial Catheterization An arterial catheter is a thin, hollow tube ... PHYSICIANS: AND COPY Why Do I Need Arterial Catheterization? Common reasons an arterial catheterization is done include: ■ ...

  1. Lifetime risk factors and arterial pulse wave velocity in adulthood: the cardiovascular risk in young Finns study.

    Science.gov (United States)

    Aatola, Heikki; Hutri-Kähönen, Nina; Juonala, Markus; Viikari, Jorma S A; Hulkkonen, Janne; Laitinen, Tomi; Taittonen, Leena; Lehtimäki, Terho; Raitakari, Olli T; Kähönen, Mika

    2010-03-01

    Limited and partly controversial data are available regarding the relationship of arterial pulse wave velocity and childhood cardiovascular risk factors. We studied how risk factors identified in childhood and adulthood predict pulse wave velocity assessed in adulthood. The study cohort consisted of 1691 white adults aged 30 to 45 years who had risk factor data available since childhood. Pulse wave velocity was assessed noninvasively by whole-body impedance cardiography. The number of conventional childhood and adulthood risk factors (extreme quintiles for low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, body mass index, and smoking) was directly associated with pulse wave velocity in adulthood (P=0.005 and P<0.0001, respectively). In multivariable regression analysis, independent predictors of pulse wave velocity were sex (P<0.0001), age (P<0.0001), childhood systolic blood pressure (P=0.002) and glucose (P=0.02), and adulthood systolic blood pressure (P<0.0001), insulin (P=0.0009), and triglycerides (P=0.003). Reduction in the number of risk factors (P<0.0001) and a favorable change in obesity status (P=0.0002) from childhood to adulthood were associated with lower pulse wave velocity in adulthood. Conventional risk factors in childhood and adulthood predict pulse wave velocity in adulthood. Favorable changes in risk factor and obesity status from childhood to adulthood are associated with lower pulse wave velocity in adulthood. These results support efforts for a reduction of conventional risk factors both in childhood and adulthood in the primary prevention of atherosclerosis. PMID:20083727

  2. Comportamiento de prótesis dentales removibles como factor causal de estomatitis sub-protésica: reporte de un caso

    OpenAIRE

    Rebolledo Cobos, Martha Leonor; Pastor Martinez, Mayra

    2012-01-01

    La presencia de prótesis removibles en la cavidad bucal acompañada de condiciones como: deficiente adaptación y ajuste, poca higiene bucal, presencia de microorganismos, hábitos, vicios incluyendo factores sistémicos, corresponde un factor causal para la aparición de estomatitis sub-protésica (ESP). Esta entidad patológica se caracteriza por la presencia de lesiones inflamatorias eritematosas, asintomáticas, de mayor prevalencia en el maxilar y con predilección al sexo femenino. Su tratamient...

  3. El control del río Colorado como factor histórico La necesidad de estudiar la relación tierra/agua

    OpenAIRE

    Marco Antonio Samaniego López

    2008-01-01

    El artículo propone la necesidad del análisis de la relación entre la tierra y el agua, como método indispensable para comprender el desarrollo del Valle de Mexicali. Analiza el factor de que el río forme parte de una cuenca internacional y las implicaciones que tuvo la modificación paulatina de la corriente. Demuestra que la discusión centrada en la tierra, si bien importante y de aportaciones significativas, está lejos de explicar la problemática de la región, ya que el agua es un factor de...

  4. INCREMENTO TRANSITORIO DE LA PRESION ARTERIAL SISTEMICA EN PACIENTES NORMOTENSOS CON TERAPEUTICA ACUPUNTURAL

    OpenAIRE

    RECAMIER TORRES, BERNARDO DEL SAGRADO CORAZON DE JESUS

    2009-01-01

    INTRODUCCION. LA PRESION ARTERIAL SISTEMICA RESULTADO DE LA INTERACCION DE FACTORES NEUROENDOCRINOS SOBRE EL TONO VASCULAR SISTEMICO Y VOLUMEN SANGUINEO CIRCULANTE, ES MODIFICADA POR LA TERAPEUTICA ACUPUNTURAL A TRAVES DEL INCREMENTO DE NEUROPEPTIDOS COMO ENDORFINAS, Y SUS PRECURSORES, (SITUACION DEMOSTRADA POR LAS EXPERIENCIAS DE POMERANZ). ESTE AUMENTO DE LA ACTIVIDAD EN LA RED CEFALO SUPRARRENAL CONLLEVA A UN INCREMENTO EN LA PRESION ARTERIAL SISTEMICA QUE REQUIERE DE MECANISMOS COMPENSAD...

  5. A Study of Prevalence of Risk Factors for Coronary Artery Diseases in Asymptomatic Middle Aged and Elderly Subjects

    Directory of Open Access Journals (Sweden)

    Arvind Kumar, Sandeep Garg, Hem Lata Gupta

    2005-04-01

    Full Text Available This study was conducted to determine the prevalence of risk factors for coronary artery disease(CAD in apparently healthy middle aged and elderly population and to find the different betweenurban and rural group.Atotal of 160 individuals (80 urban and 80 rural were included in the study.All the subjects underwent detailed history and physical examination with special emphasis oncardiovascular system. The biochemical investigations were done in all the subjects which includedblood sugar, serum LDL and serum triglyceride levels. The prevalence of 2 or more than 2 riskfactors were observed in 95% subjects. The prevalence of smoking was 63%, which was moreprevalent in the rural population. The sedentary lifestyle was seen in 80% subjects more in femalesand urban group. The prevalence of asymptomatic hypertensives and isolated systolic hypertensionwere seen in 34% and 10% individuals respectively. Other risk factors were-diabetes mellitus (4%,Increase LDL (38%, hypertriglyceridemia (23% and central obesity (27.50%. The two mostcommon risk factors for CADwere sedentary lifestyle and smoking. These risk factors are modifiableand their reduction during adulthood can lead to marked reduction in the burden of CAD in middleaged and elderly Indian population.

  6. Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes.

    Science.gov (United States)

    Kim, Won Jin; Kim, Sang Soo; Lee, Han Cheol; Song, Sang Heon; Bae, Min Jung; Yi, Yang Seon; Jeon, Yun Kyung; Kim, Bo Hyun; Kim, Yong Ki; Kim, In Joo

    2015-05-01

    The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus. Serum FGF-21 was measured in 120 patients undergoing coronary angiography. Patients were divided into 4 groups based on the presence/absence of type 2 diabetes mellitus and of significant CAD. The atherosclerotic burden was obtained by two angiographic scores: Gensini score (GS) and Extent score (ES). FGF-21 levels were higher in type 2 diabetes mellitus than in non-diabetic patients (P = 0.014). FGF-21 levels were significantly correlated with GS (r = 0.358, P CAD feature had elevated FGF-21 levels. Despite of a limited role in diabetic patients, FGF-21 levels are independently associated with angiographic severity and extent of CAD. PMID:25931789

  7. Superficial and deep sternal wound infection after more than 9000 coronary artery bypass graft (CABG: incidence, risk factors and mortality

    Directory of Open Access Journals (Sweden)

    Abbasi Kyomars

    2007-09-01

    Full Text Available Abstract Background Sternal wound infection (SWI is an uncommon but potentially life-threatening complication of cardiac surgery. Predisposing factors for SWI are multiple with varied frequencies in different studies. The purpose of this study was to assess the incidence, risk factors, and mortality of SWI after coronary artery bypass grafting (CABG at Tehran Heart Center. Methods This study prospectively evaluated multiple risk factors for SWI in 9201 patients who underwent CABG at Tehran Heart Center between January 2002 and February 2006. Cases of SWI were confirmed based on the criteria of the Centers for Disease Control and Prevention. Deep SWI (bone and mediastinitis was categorized according to the Oakley classification. Results In the study period, 9201 CABGs were performed with a total SWI rate of 0.47 percent (44 cases and deep SWI of 0.22 percent (21 cases. Perioperative (in-hospital mortality was 9.1% for total SWI and about 14% for deep SWI versus 1.1% for non-SWI CABG patients. Female gender, preoperative hypertension, high functional class, diabetes mellitus, obesity, prolonged intubation time (more than 48 h, and re-exploration for bleeding were significant risk factors for developing SWI (p = 0.05 in univariate analysis. In multivariate analysis, hypertension (OR = 10.7, re-exploration (OR = 13.4, and female gender (OR = 2.7 were identified as significant predictors of SWI (p Conclusion Rarely reported previously, the two risk factors of hypertension and the female gender were significant risk factors in our study. Conversely, some other risk factors such as cigarette smoking and age mentioned as significant in other reports were not significant in our study. Further studies are needed for better documentation.

  8. Consumo precoz de tabaco y alcohol como factores modificadores del riesgo de uso de marihuana Early tobacco and alcohol consumption as modifying risk factors on marijuana use

    OpenAIRE

    Verónica Iglesias; Gabriel Cavada; Claudio Silva; Dante Cáceres

    2007-01-01

    OBJETIVO: Evaluar la relación entre consumo precoz de tabaco y alcohol y el riesgo de consumir marihuana en escolares. MÉTODOS: Estudio transversal con datos del IV Estudio Nacional de Consumo de Drogas en Población Escolar, año 2001. Se analizó 54,001 escolares de ocho a 20 años de edad. Como variables predictoras se consideró el autoreporte de consumo de tabaco y alcohol, la edad de inicio de consumo de tabaco y/o alcohol, y la intensidad de uso del tabaco. Como variable resultado se utiliz...

  9. Seleção da artéria radial para utilização como enxerto aortocoronário: correlação cirúrgica x avaliação pré-operatória com ecocolor Doppler e fotopletismografia digital Radial artery selection as coronary artery bypass graft: surgical correlation vs preoperative evaluation by using echocolor Doppler and digital photoplethysmography

    Directory of Open Access Journals (Sweden)

    Melchior Luis LIMA

    2002-03-01

    , devido ao comprometimento bilateral. Em 3 pacientes que, por diferentes motivos, não foram submetidos ao estudo pelo Ecocolor Doppler e pela fotopletismografia, a avaliação clínica da perviedade da artéria radial utilizando a manobra de Allen não foi suficiente para afastar a presença de calcificação da parede arterial encontrada no ato operatório, impossibilitando o uso dessa artéria como enxerto. CONCLUSÃO: Os autores concluem que a seleção da artéria radial para utilização como ponte aortocoronária, avaliada por testes não invasivos, como o ECD e a fotopletismografia, é eficaz, pois a associação desses métodos apresenta excelente correlação com os achados per-operatórios e permite a nós, cirurgiões cardiovasculares, além da segurança, um melhor planejamento cirúrgico para cada paciente.INTRODUCTION: With the growing use of the radial artery as a coronary artery bypass graft, becomes necessary to revalue the criteria used for the selection of that vessel in the preoperative of the surgery of coronary artery bypass graft (CABG. The objective of this study was to correlate the evaluation of the viability of the vessel for the heart surgeon at surgery with the study of selection of the radial artery for the methods non invasivos, as EchocolorDoppler(ECD and the digital photoplethysmography(PPG. METHODS: Between July of 1998 and January of 2000, 78 radial arteries and 78 arteries ulnares of 39 patients selected for CABG, were studied. The study was carried out bilaterally, using duplex ultrasound ATL - HDI 5000 and Acuson - Sequoia 512, and for the photoplethysmography an apparel Parks Vascular Mini - Lab Model 1052-C. The radial artery was considered susceptible to be used as coronary artery graft bypass, when it filled out the following criteria: ateromatose absence or occlusion of the radial artery and ulnar ipsilateral, internal diameter of the larger radial artery or equal to 2.5mm, appraised for ECD, and presence of pulse wave in two or

  10. Competencia literaria en educación infantil: estrategias didácticas y materiales literarios como factores de desarrollo

    OpenAIRE

    Arellano Chávez, María Josefina Juana

    2012-01-01

    Esta tesis doctoral cobra importancia para México y otras latitudes porque tiene como base la aspiración de que en las aulas preescolares se desarrolle la Competencia Literaria a través del ejercicio de la Lectura Literaria con placer. Busca acrecentar la calidad de la cultura escolar en general, y la literaria en particular, contribuyendo a la comprensión y desarrollo de conocimientos, actitudes y aptitudes, es decir competencias, no sólo en el área de lenguaje y comunicación, sino tambi...

  11. Innovación tecnológica como factor de aglomeración espacial en las regiones colombianas

    OpenAIRE

    Maldonado Norman

    2009-01-01

    Los desbordamientos de conocimiento, como fuente de innovación tecnológica, requieren espacios –ciudades y regiones– que permitan la interacción entre individuos y firmas. En este artículo se analizan los patrones de especialización y diversificación y el ambiente competitivo de industrias colombianas en diferentes regiones, con sus tasas de crecimiento, para determinar el tipo de ambiente que favorece la presencia de desbordamientos de conocimiento.

  12. Utilidad de la capilaroscopia como factor pronóstico en la esclerodermia sistémica

    OpenAIRE

    De Iriarte Gay de Montellá, Natalia

    2013-01-01

    La Esclerodermia sistémica (ES) es una enfermedad que afecta al tejido conectivo, caracterizada por un depósito excesivo de colágeno en los tejidos así como alteraciones vasculares en la microcirculación en el contexto de un ambiente inmunológico alterado. Su característica fundamental es la induración cutánea, aunque es frecuente la afectación de órganos internos, principalmente aparato digestivo, respiratorio, renal y cardíaco, dando lugar a un amplio espectro de manifestaciones que puede c...

  13. Protocolo de investigación: Consumo de yogur como factor protector de Diabetes Mellitus tipo 2

    OpenAIRE

    Cócera García, Alberto

    2015-01-01

    OBJETIVO: estudiar la asociación entre el consumo de yogur y el riesgo de desarrollar DMT2 en la población adulta abulense con riesgo moderado, alto y muy alto de desarrollar esta patología. DISEÑO: Estudio de cohortes dinámicas prospectivas de carácter longitudinal multicéntrico. Con un periodo de seguimiento de 15 años. SUJETOS: Cohorte expuesta: 9.595 sujetos adultos en riesgo de desarrollar Diabetes Tipo 2 que consumen un yogur al día como mínimo. Cohorte no expuesta: 9....

  14. Factores de atracción de Alicante como destino residencial: el punto de vista de los residentes europeos

    OpenAIRE

    Huete Nieves, Raquel

    2005-01-01

    Exposición de las principales razones por las que un número cada vez mayor de ciudadanos europeos en situación de inactividad laboral deciden trasladarse y asentarse, de forma más o menos estable, en la provincia de Alicante. La publicidad generada por parte de organismos públicos, agentes turísticos y promotoras inmobiliarias ha ido formando una determinada imagen de la provincia, conocida ya en su conjunto como Costa Blanca, que ha calado en un segmento de población extranjera demandante de...

  15. Plasma von Willebrand factor as a predictor of survival in pulmonary arterial hypertension associated with congenital heart disease

    Directory of Open Access Journals (Sweden)

    A.A. Lopes

    2011-12-01

    Full Text Available Biomarkers have been identified for pulmonary arterial hypertension, but are less well defined for specific etiologies such as congenital heart disease-associated pulmonary arterial hypertension (CHDPAH. We measured plasma levels of eight microvascular dysfunction markers in CHDPAH, and tested for associations with survival. A cohort of 46 inoperable CHDPAH patients (age 15.0 to 60.2 years, median 33.5 years, female:male 29:17 was prospectively followed for 0.7 to 4.0 years (median 3.6 years. Plasma levels of von Willebrand factor antigen (VWF:Ag, tissue plasminogen activator (t-PA and its inhibitor (PAI-1, P-selectin, reactive C-protein, tumor necrosis factor alpha, and interleukin-6 and -10 were measured at baseline, and at 30, 90, and 180 days in all subjects. Levels of six of the eight proteins were significantly increased in patients versus controls (13 to 106% increase, P < 0.003. Interleukin-10 level was 2.06 times normal (P = 0.0003; Th2 cytokine response. Increased levels of four proteins (t-PA, PAI-1, P-selectin, and interleukin-6 correlated with disease severity indices (P < 0.05. Seven patients died during follow-up. An average VWF:Ag (mean of four determinations above the level corresponding to the 95th percentile of controls (139 U/dL was independently associated with a high risk of death (hazard ratio = 6.56, 95%CI = 1.46 to 29.4, P = 0.014. Thus, in CHDPAH, microvascular dysfunction appears to involve Th2 inflammatory response. Of the biomarkers studied, plasma vWF:Ag was independently associated with survival.

  16. Factores de conversión. Como calcular la cantidad de materia orgánica en una muestra analizada por dicromatometría.

    OpenAIRE

    Milla González, Miguel; Pinto Ganfornina, Juan José

    2014-01-01

    La materia orgánica de una muestra de suelo o sedimento se determina mediante una valoración por retroceso utilizando dicromato potásico como oxidante y una sal ferrosa como valorante. En este ejercicio se encuentra la relación entre el volumen añadido de agente oxidante (V) y los volúmenes de sal de Fe(II) consumidos en la valoración del exceso de dicromato (V1) y de un blanco de referencia (V2). Si se convierten los volúmenes V1 y V2 en volumen de dicromato, el factor de conversión correspo...

  17. Consumo precoz de tabaco y alcohol como factores modificadores del riesgo de uso de marihuana Early tobacco and alcohol consumption as modifying risk factors on marijuana use

    Directory of Open Access Journals (Sweden)

    Verónica Iglesias

    2007-08-01

    Full Text Available OBJETIVO: Evaluar la relación entre consumo precoz de tabaco y alcohol y el riesgo de consumir marihuana en escolares. MÉTODOS: Estudio transversal con datos del IV Estudio Nacional de Consumo de Drogas en Población Escolar, año 2001. Se analizó 54,001 escolares de ocho a 20 años de edad. Como variables predictoras se consideró el autoreporte de consumo de tabaco y alcohol, la edad de inicio de consumo de tabaco y/o alcohol, y la intensidad de uso del tabaco. Como variable resultado se utilizó el autoreporte de uso de marihuana y la edad de inicio de consumo de ésta. Para el análisis de los datos se utilizó regresión de Poisson y regresión de Weibull. RESULTADOS: Los escolares presentaron alta prevalencia de consumo de tabaco, alcohol y marihuana (77%, 79% y 23% respectivamente. El consumo de tabaco en presencia de consumo de alcohol fue un factor de riesgo de uso de marihuana (RP=10.4; IC 95%: 8.9;12.2. El inicio tardío de consumo de tabaco (HR=0.85; IC 95%: 0.84;0.86 y alcohol (HR=0.90; IC 95%: 0.89;0.91 resultó ser un factor protector del uso de marihuana. La probabilidad de consumo de marihuana fue mayor en quienes fumaban todos o casi todos los días en relación a quienes fumaban sólo los fines de semana (RP=3.11; IC 95%: 2.96;3.26 vs. RP=1.70; IC 95%: 1.58;1.83. CONCLUSIONES: El riesgo de consumo de marihuana se asoció significativamente con la edad de inicio de consumo de tabaco, la frecuencia de consumo de tabaco y el consumo simultáneo de alcohol. Las estrategias de prevención deberían orientarse a evitar el consumo precoz de tabaco en escolares.OBJETIVO: Avaliar a relação entre consumo precoce de tabaco e álcool e o risco de consumir maconha por escolares. MÉTODOS: Estudo transversal com dados do IV Estudio Nacional de Consumo de Drogas en Población Escolar, ano 2001 no Chile. Analisaram-se 54.001 escolares de oito a 20 anos de idade. As variáveis preditoras consideradas foram: consumo de tabaco e álcool, a

  18. Study of pattern of dyslipidemia and its correlation with cardiovascular risk factors in patients with proven coronary artery disease

    Directory of Open Access Journals (Sweden)

    Namita Mahalle

    2014-01-01

    Full Text Available Introduction: Dyslipidemia is a primary, widely established as an independent major risk factor for coronary artery disease (CAD. Asians differs in prevalence of various lipid abnormalities than non-Asians. Hence, this study was conducted with objective to evaluate the lipid abnormalities and there correlation with traditional and non-traditional risk factors in known subjects with CAD. Materials and Methods: We studied the pattern and association of dyslipidemia with cardiovascular risk factors in 300 (Male: 216; Female: 84, age: 60.9 ± 12.4 years, range: 25-92 years angiographically proved CAD patients. All patients were evaluated for anthropometry and cardiovascular risk factors and blood samples were collected for biochemical and inflammatory markers. Results: Hypercholesterolemia, hypertriglyceridemia and low high density lipoprotein (HDL was present in 23.3%, 63.0% and 54.6% in the total study population respectively. A total of 41.3% had atherogenic dyslipidemia (raised triglycerides [TG] and low HDL. Percentage of patients with type-2 diabetes mellitus and hypertension were higher in subjects with atherogenic dyslipidemia. Insulin sensitivity was low; insulin and insulin resistance (IR along with inflammatory markers were high in subjects with atherogenic dyslipidemia. Patients with atherogenic dyslipidemia had significantly lower serum vitamin B12 levels and higher homocysteine (Hcy levels. Hypertriglyceridemia was positively correlated with insulin, homeostasis model assessment of IR, Hcy, interleukin-6, Tumor necrosis factor-alpha, highly sensitive C-reactive protein and negatively with vitamin B12 and quantitative insulin check index and an opposite correlation of all quoted parameters was observed with low HDL. The correlation of traditional and non-traditional risk factors was stronger with low HDL and high TG compared with hypercholesterolemia. Conclusions: Hypertriglyceridemia and low HDL cholesterol is common in patients with

  19. Percutaneous Radiofrequency Ablation and Transcatheter Arterial Chemoembolization for Hypervascular Hepatocellular Carcinoma: Rate and Risk Factors for Local Recurrence

    International Nuclear Information System (INIS)

    Purpose. To analyze local recurrence-free rates and risk factors for recurrence following percutaneous radiofrequency ablation (RFA) or transcatheter arterial chemoembolization (TACE) for hypervascular hepatocellular carcinoma (HCC). Methods. One hundred and nine nodules treated by RFA and 173 nodules treated by TACE were included. Hypovascular nodules were excluded from this study. Overall local recurrence-free rates of each treatment group were calculated using the Kaplan-Meier method. The independent risk factors of local recurrence and the hazard ratios were analyzed using Cox's proportional-hazards regression model. Based on the results of multivariate analyses, we classified HCC nodules into four subgroups: central nodules ≤2 cm or >2 cm and peripheral nodules ≤2 cm or >2 cm. The local recurrence-free rates of these subgroups for each treatment were also calculated. Results. The overall local recurrence-free rate was significantly higher in the RFA group than in the TACE group (p = 0.013). The 24-month local recurrence-free rates in the RFA and TACE groups were 60.0% and 48.9%, respectively. In the RFA group, the only significant risk factor for recurrence was tumor size >2 cm in greatest dimension. In the TACE group, a central location was the only significant risk factor for recurrence. In central nodules that were ≤2 cm, the local recurrence-free rate was significantly higher in the RFA group than in the TACE group (p 2 cm was the only independent risk factor for local recurrence in RFA treatment, and a central location was the only independent risk factor in TACE treatment. Central lesions measuring ≤2 cm should be treated by RFA

  20. Prevalencia del factor v leiden y la mutación G20210A del gen de la protrombina en Navarra, y su papel como factores de riesgo trombótico

    OpenAIRE

    Zabalegui, N. (Natalia); Rocha, E; Montes, R.

    2011-01-01

    El presente trabajo en un intento de esclarecer el mayor número posible de aspectos relacionados con los dos factores de riesgo FV Leiden y Protrombina G20210A, de trombofilia hereditaria más comunes en Occidente, así como de aportar información acerca de su presencia y agresividad dentro de nuestro medio. Así, nuestros objetivos fueron los siguientes: 1. Establecer la prevalencia de FV Leiden y Protrombina G20210A en la población control, así como en la población oriunda de Navarra. ...

  1. Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease

    Directory of Open Access Journals (Sweden)

    Soudabeh Fallah

    2016-01-01

    Full Text Available ABSTRACT This work aimed to determine whether seropositivity to Helicobacter pylori infection was an independent risk factor for hyperhomocysteinemia patients with cardiovascular disease. The H. pylori IgG, IgA and homocystein levels in 96 patients with cardiovascular disease and 64 participants free of cardiovascular disease as control subjects were determined by ELISA assay. The results showed that seropositivity to H. pylori IgG and IgA levels of coronary artery disease (CADpatients was significantly higher than the controls and CAD patients with H. pylori IgG and IgA negative antibodies. A significant correlation was found between the seropositivity to H. pylori IgG and homocysteine levels of CAD patients in comparison with the controls and CAD patients with seronegativity to H. pylori IgG and IgA (r=0.233, P= 0.019 . The involvement of H. pylori infection in atherosclerosis process was based on the chronic inflammation, which might facilitate the CAD-related pathologies. The effect of the presence of H. pylori infection on homocysteine levels elevation in the CAD patients (as a risk factor independent of other traditional factors was remarkable.

  2. Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat

    DEFF Research Database (Denmark)

    Stankevicius, Edgaras; Dalsgaard, Thomas; Kroigaard, Christel;

    2011-01-01

    current, and NO release that were blocked by apamin and TRAM-34 or charybdotoxin. These findings suggest that opening of SK(Ca) and IK(Ca) channels leads to endothelium-dependent relaxation that is mediated mainly by NO in large mesenteric arteries and by EDHF-type relaxation in small mesenteric arteries......This study was designed to investigate whether calcium-activated potassium channels of small (SK(Ca) or K(Ca)2) and intermediate (IK(Ca) or K(Ca)3.1) conductance activated by 6,7-dichloro-1H-indole-2,3-dione 3-oxime (NS309) are involved in both nitric oxide (NO) and endothelium......-derived hyperpolarizing factor (EDHF)-type relaxation in large and small rat mesenteric arteries. Segments of rat superior and small mesenteric arteries were mounted in myographs for functional studies. NO was recorded using NO microsensors. SK(Ca) and IK(Ca) channel currents and mRNA expression were investigated in...

  3. Effects of chronic renal failure rat serum on histone acetyltransferase p300 and activation of activating transcription factor 4 of arterial smooth muscle cells cultured in vitro

    Institute of Scientific and Technical Information of China (English)

    张耀全

    2014-01-01

    Objective To investigate the effects of the rat serum with chronic renal failure(CRF)on ubiquitin-proteasome pathway,histone acetyltransferase p300 and activation of activating transcription factor 4(ATF4)of rat arterial vascular smooth muscle cells(VSMCs)cultured in vitro,and explore the possible mechanism.Methods Objective To establish the rat model of

  4. Cytokines and growth factors modify the upregulation of contractile endothelin ET(A) and ET(B) receptors in rat cerebral arteries after organ culture

    DEFF Research Database (Denmark)

    Ahnstedt, H; Stenman, E; Cao, L; Henriksson, M; Edvinsson, L

    2012-01-01

    Experimental cerebral ischaemia and organ culture of cerebral arteries induce an increased endothelin ET(B) receptor-mediated contraction. The aim of this study was to examine whether cytokines and growth factors, known to be activated in ischaemia, can influence the expression and function of...... endothelin receptors after organ culture....

  5. La hiperhomocisteinemia como factor de riesgo vascular en hemodializados crónicos Hyperhomocysteinemia as a vascular risk factor in chronic hemodialysis patients

    Directory of Open Access Journals (Sweden)

    Hernán Trimarchi

    2005-12-01

    Full Text Available La homocisteína es un factor de riesgo independiente de enfermedad cardiovascular en la población general, y juega un rol protagónico en el desarrollo de la aterogénesis y las trombosis vasculares, sobre todo en pacientes con insuficiencia renal. Así pues, los pacientes en hemodiálisis están bajo los efectos tóxicos de la hiperhomocisteinemia, presente en cerca del 90% de estos pacientes. En nuestra experiencia hemos encontrado que el ácido fólico es un tratamiento eficaz para disminuir los niveles de homocisteína, y el agregado de metilcobalamina intravenosa potencia este efecto; sin embargo, la metilcobalamina por sí sola fue insuficiente para normalizar la homocisteinemia. A lo largo del tiempo, un grupo de pacientes requirió dosis más elevadas de ácido fólico para corregir la hiperhomocisteinemia. Los pacientes homocigotas y, en menor medida hete-rocigotas para la variante termolábil C677T de la enzima metilentetrahidrofolato reductasa (MTHFR, presentaron una actividad catalítica reducida reflejada en la necesidad de una mayor dosis de ácido fólico para normalizar los niveles de homocisteína. Los efectos trombóticos vasculares fueron similares en todos los pacientes respecto a las variantes genéticas de la enzima metilentetrahidrofolato reductasa, sugiriendo que el tratamiento de la hiperhomocisteinemia es importante para disminuir el riesgo de trombosis. Sin embargo, también la hipoho-mocisteinemia, asociada generalmente a estados de desnutrición, se asocia a mayor mortalidad. Si bien se considera a la hiperhomocisteinemia como un factor de riesgo vascular en los pacientes con insuficiencia renal, aún no se determinó en esta población si su corrección se asocia a una disminución de la tasa de enfermedad vascular y de trombosis. No obstante, ante los hallazgos mencionados y dado el bajo riesgo y la buena tolerancia al tratamiento vitamínico, creemos útil conocer los niveles de folato, cobalamina y homo

  6. Nutritional related cardiovascular risk factors in patients with coronary artery disease in IRAN: A case-control study

    Directory of Open Access Journals (Sweden)

    Afzali Naser

    2010-12-01

    Full Text Available Abstract Background and aims There are limited findings available on coronary artery disease (CAD risk factors and nutritional pattern of CAD patients in Iran. The purpose of this study was to compare nutritional-related risk factors of CAD patients with that of matched controls. Methods In a case-control design, dietary patterns and CAD risk factors of 108 documented patients (determined by cardiac catheterization showing greater than 70% stenosis or established myocardial infarction whom were admitted to coronary care units (CCU of Ahvaz teaching hospitals were compared with that of 108 gender- and age-matched subjects of normal cardiac catheterization (lesser than 40% stenosis. Measured variables consisted of blood lipid profile, smoking habits, dietary patterns, anthropometric indices and blood pressure levels. Results Almost all patients had hypertriglyceridemia and high LDL-C levels. Odds ratios (CI 95% for consuming fish, tea, vegetable oils were 0.55(0.31-0.91, 0.3(0.15-0.65, 0.23(0.13-0.42, respectively. However, consumption of hydrogenated fats, and full-fat yoghurt was associated with higher CAD risk (OR = 2.12(1.23-3.64 and 2.35(1.32-4.18, respectively. Patients' serum lipid profiles, sugar concentrations, and blood pressure levels were significantly higher than defined cut-off points of the known risk factors. Considerable numbers of the control group also showed high levels of the known risk factors. Conclusions Consumption of fish, tea and vegetable oils shown to have protective effect on CAD while full fat yoghurt and hydrogenated fats increase the risk of CAD. Moreover, CAD patients obviously have higher blood lipids and sugar concentrations, blood pressure, body fat percent and BMI levels compared with their matched counterparts. We need to define specific local cut-off points with more practical criteria to detect CAD patients.

  7. Factores de riesgo como pronóstico de padecer cáncer de mama en un estado de México

    OpenAIRE

    M.ª J. Aguilar Cordero; M. Neri Sánchez; C. A. Padilla López; M. L. Pimentel Ramírez; A. García Rillo; A. M. Sánchez López

    2012-01-01

    Introducción: El cáncer de mama es una de las patología más frecuentes de la mujer y con gran impacto en la sociedad. Los factores de riesgo más estudiados han sido los hormonales, los genéticos y los ambientales, aunque también los hábitos tóxicos, el sobrepeso y la obesidad; como factores protectores, por el contrario, la lactancia materna y la actividad física. Objetivo: Conocer los factores de riesgo de las mujeres con cáncer de mama en nuestro grupo de estudio. Material y métodos: Se rea...

  8. Marcadores inmunológicos como factores pronósticos en el síndrome de Sjögren primario

    OpenAIRE

    Brito Zerón, María del Pilar

    2006-01-01

    [spa] ANTECEDENTES DEL TEMA. El síndrome de Sjögren primario (SSp) es una enfermedad autoinmune sistémica que afecta a las glándulas exocrinas, principalmente las salivales y las lacrimales, originando síntomas de sequedad. La expresión clínica también incluye manifestaciones generales, afección extraglandular y desarrollo de linfoma. La influencia de los marcadores inmunológicos en la expresión clínica de la enfermedad aún no se conoce del todo y tampoco su papel como factores pronóstico de ...

  9. La influencia de la ira y la depresión como posibles factores de riesgo en la adaptación a la enfermedad cardiovascular

    OpenAIRE

    Valls Lázaro, Esperanza; Rueda Laffond, Beatriz

    2010-01-01

    El presente estudio tuvo como objetivos: (I) examinar, en una muestra de pacientes cardiovasculares, las diferencias en función del sexo en relación con: la ira y depresión; las estrategias de afrontamiento; la calidad de vida (CV); y con dos criterios cardiovasculares (enfermedad coronaria y factores de riesgo), (II) estudiar la capacidad predictiva de la ira y la depresión con respecto a los criterios cardiovasculares, las estrategias de afrontamiento y la CV. Los...

  10. El Clima Organizacional Como Factor de Competitividad en las FranQuicias de Comida Rapida en Tijuana, B.C., Mexico

    OpenAIRE

    Maria Virginia Flores-Oritz; Alfonso Vega-Lopez; Edgar ARmando Chavez-Moreno

    2015-01-01

    El presente trabajo contempla una investigación para conocer la relación que existe entre el clima organizacional como factor de competitividad en las franquicias de comida rápida en Tijuana, B.C.; sin lugar a dudas el primordial activo de las organizaciones es el recurso humano ya que es a través de un buen equipo de trabajo que la empresa logra sus objetivos y metas asegurando así su desarrollo y posicionamiento en el mercado, no se debe dejar de lado el clima organizacional y la importanci...

  11. El control del río Colorado como factor histórico La necesidad de estudiar la relación tierra/agua

    OpenAIRE

    Marco Antonio Samaniego López

    2008-01-01

    El artículo propone la necesidad del análisis de la relación entre la tierra y el agua, como método indispensable para comprender el desarrollo del Valle de Mexicali. Analiza el factor de que el río forme parte de una cuenca internacional y las implicaciones que tuvo la modificación paulatina de la corriente. Demuestra que la discusión centrada en la tierra, si bien importante y de aportaciones significativas, está lejos de explicar la problemática de la región, ya que el agua es ...

  12. Promover en los adolescentes la identificación de sus valores como factores que les protegen de las adicciones: un modelo vivencial centrado en el estudiante

    OpenAIRE

    González Flores, María del Pilar; María Luisa SEVILLANO GARCÍA; Luis REY YEDRA

    2007-01-01

    RESUMEN: En el presente trabajo mostramos una propuesta de intervención surgida de un estudio amplio realizado en la ciudad de Xalapa, Veracruz, México con una muestra representativa de adolescentes no consumidores de sustancias adictivas. Esta propuesta pretende ser una aportación para la identificación y el fortalecimiento de los valores como factor de protección a pesar de la disponibilidad y facilidad de acceso a las drogas en el medio. Diseñamos un programa integral que ayude a los niños...

  13. Trastornos menores de salud como factores asociados al desempeño académico de estudiantes de enfermería.

    OpenAIRE

    Ayala Valenzuela, R.; Pérez Uribe, M.; Obando Calderón, I.

    2010-01-01

    La evidencia muestra los trastornos menores en salud en estudiantes universitarios como un factor relevante de ser estudiado. Una variable asociada al rendimiento académico, no tan sólo por las características individuales de ellos, sino también por lo que significa el integrarse a un sistema que impone una serie de exigencias y demandas, por ejemplo un cambio en el desempeño de roles, organización del tiempo, entre otras, que deben compatibilizar con sus hábitos de adolescentes, actitudes y ...

  14. El tacto como factor de humanización en la fase terminal Tact as a humanization factor during the terminal phase

    Directory of Open Access Journals (Sweden)

    Tiberio Alvarez Echeverri

    1993-03-01

    Full Text Available

    Se hace una descripción del tacto como el sentido que aparece más precozmente durante la vida embrionaria y de su significado para el desarrollo armónico de la personalidad y como forma de comunicación Interhumana. Se discute cuándo es apropiado el tacto en las relaciones con los demás; se describen sus cualidades y niveles comunicativos. Finalmente, se destaca la importancia del sentido del tacto como una forma muy efectiva de comunicación con el enfermo en fase terminal.

    The sense of touch is the first one to appear during embryonic Life and Its significance for the armonic development of personality and as an effective mean of communication are described, as well as, the appropiateness of touching in the relationship between persons and the quality and communicative levels of tact. Finally, the relevance of tact for communicating with terminal patients is emphasized.

  15. High-sensitivity C-reactive protein (hs-CRP) and tumor necrotizing factor-alpha (TNF-alpha) after on- and off- pump coronary artery bypass grafting

    OpenAIRE

    Javadzadegan, H; Nezami, N; Ghobadi, K; Sadighi, A; Abolfathi, A A; Nader, N D

    2010-01-01

    Introduction Coronary artery bypass grafting (CABG) is one of the most frequently performed operations around the world. The aim of this study is to evaluate high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-alpha (TNF-alpha) differences between on-pump and off-pump coronary surgery. Methods In this prospective study, 90 patients with coronary artery disease referred for CABG were enrolled from July 2006-November 2007. Levels of hs-CRP and TNF-alpha were measured by ELISA...

  16. Diferencia elevada de presión arterial interbraquial: Frecuencia y factores clínicos y demográficos

    OpenAIRE

    David Hurtado de Mendoza; Roberto Pineda-Reyes; Jacsel Suárez; Wilfredo Mormontoy; Félix Medina

    2015-01-01

    La diferencia elevada de presión arterial interbraquial (DEPAI) podría predecir eventos cardiovasculares adversos. Objetivos: Conocer la frecuencia de DEPAI y describir factores clínicos y demográficos relacionados. Material y métodos: Estudio descriptivo transversal. Muestra aleatoria de 211 pacientes de un hospital público de Lima. Se tomó la presión arterial tres veces, de forma simultánea en ambos brazos, con dos tensiómetros automáticos OMROM HEM-705CP propiamente calibrados, estando el ...

  17. METABOLIC AND AUTOIMMUNE RISK FACTORS FOR CORONARY ARTERY DISEASE (CAD IN HEART TRANSPLANT RECIPIENTS

    Directory of Open Access Journals (Sweden)

    T. A. Khalilulin

    2010-01-01

    Full Text Available One of the most essential autoimmunity risk factors for development of CAD are increasing level of anticardiolipin antibodies and homocystein. This report presents retrospective analyses of 39 heart transplant recipients with maximal follow up over 16 years. Our results showed that hyperhomocystenemia and high levels of anticardiolipin antibodies play great value in development of CAD. Thus relative risks for development of CAD in presence both high levels of anticardiolipin antibodies and homocysteine are higher, than in traditional nonimmune risk factors

  18. Hereditary dyslipidaemias and combined risk factors in children with a family history of premature coronary artery disease

    Science.gov (United States)

    Sveger, T; Flodmark, C; Nordborg, K; Nilsson-Ehle, P; Borgfors, N

    2000-01-01

    AIM—Schoolchildren aged 10-11 with a family history of premature coronary artery disease (CAD), were examined in order to identify children with genetically determined dyslipidaemias and a combination of risk factors.
METHODS—A total of 4000 questionnaires were distributed by the school; 55% of the families answered and returned the questionnaire. Blood lipids, apolipoprotein B, and Lp(a) lipoprotein were analysed in high risk children and their parents.
RESULTS—A family history of premature CAD in parents or grandparents was identified in 208 families; 175 agreed to take part in a clinical examination and laboratory tests. Normal blood lipid tests were found in 89 children. Another 48 had an isolated increase of Lp(a) lipoprotein of minor clinical importance. Of the remaining 38 children, 23 had non-hereditary abnormalities of low (LDL) or high density lipoprotein (HDL) cholesterol or apolipoprotein B. Fifteen children were suspected to have genetically determined dyslipidaemias or a combination of risk factors: in four, possible familial hypercholesterolaemia (FH); in five, possible familial combined hyperlipidaemia; in three, hereditary low HDL cholesterol; and in three a combination of high LDL cholesterol and Lp(a) lipoprotein concentrations. In addition, possible FH was detected in eight of the parents.
CONCLUSION—It is worthwhile asking parents about the occurrence of premature CAD among their child's closest relatives.

 PMID:10735834

  19. Pressão Arterial em jovens como marcador de risco cardiovascular. Estudo do Rio de Janeiro Presión arterial en jóvenes como marcador de riesgo cardiovascular en jóvenes estudio de Rio de Janeiro Blood pressure in young individuals as a cardiovascular risk marker. The Rio de Janeiro study

    Directory of Open Access Journals (Sweden)

    Erika Maria Gonçalves Campana

    2009-12-01

    Full Text Available FUNDAMENTO: O estudo de variáveis de risco cardiovascular em populações jovens é fundamental para estratégias de prevenção primária OBJETIVO: Avaliar a pressão arterial (PA, perfil antropométrico e metabólico em jovens do Estudo do Rio de Janeiro, acompanhados por 17 anos. MÉTODOS: Foram avaliados 115 indivíduos (64 masculinos em três momentos (seguimento 212,23±16,0 meses: A1 (12,97±1,48 anos, A2 (21,90±1,71 anos e A3 (30,65±2,00 anos e divididos em dois grupos: GN (n=84 com pelo menos duas medidas de PA normais nas três avaliações; GH (n=31 com pelo menos duas medidas de PA anormais nas três avaliações. Nas três ocasiões foram obtidos: PA e índice de massa corporal (IMC. Em A2 e A3: glicose, triglicerídeos, colesterol total e frações. Em A3 acrescentou-se a circunferência abdominal (CA. RESULTADOS: 1 As médias da PA, IMC e CA (pFUNDAMENTO: El estudio de variables de riesgo cardiovascular en poblaciones jóvenes es fundamental para estrategias de prevención primaria. OBJETIVO: Evaluar la presión arterial (PA, perfil antropométrico y metabólico en jóvenes del Estudio de Rio de Janeiro, seguidos por 17 años. MÉTODOS: Se evaluaron 115 individuos (64 masculinos en tres momentos (seguimiento 212,23±16,0 meses: A1 (12,97±1,48 años, A2 (21,90±1,71 años y A3 (30,65±2,00 años y se dividieron en dos grupos: GN (n=84 con por lo menos dos medidas de PA normales en las tres evaluaciones; GH (n=31 con por lo menos dos medidas de PA anormales en las tres evaluaciones. En las tres ocasiones se obtuvieron: PA e índice de masa corporal (IMC. En A2 y A3: glucosa, triglicéridos, colesterol total y fracciones. En A3 se agregó la circunferencia abdominal (CA. RESULTADOS: 1 Los promedios de la PA, IMC y CA (pBACKGROUND: The study of the cardiovascular risk variables in young populations is fundamental to establish primary prevention strategies. OBJECTIVE: To evaluate the blood pressure (BP, anthropometric and metabolic

  20. Risk factors for cervical carotid and intracranial cerebrovascular lesions in patients undergoing coronary artery bypass grafting. Preoperative evaluation using magnetic resonance imaging and angiography

    Energy Technology Data Exchange (ETDEWEB)

    Makino, Masahiro [Kyoto Prefectural Univ. of Medicine (Japan). Research Inst. for Neurological Diseases and Geriatrics

    2001-12-01

    Recently neurologic complications after coronary artery bypass grafting (CABG) have received increasing attention. There is no detailed report about the risk factors for these complications, although stenosis in the cervical and intracranial arteries, especially in Japanese patients, latent ischemic brain lesions and preoperative neurological conditions are related to these events. In this prospective study, we evaluated occlusive lesions in the cervical carotid and intracranial arteries, silent brain infarction and cerebral deep white matter lesion with MRA and MRI in patients scheduled to undergo CABG to determine the prevalence of occlusive diseases in cervical carotid and intracranial arteries, latent ischemic change in the brain in this population and to identify preoperative risk factors for these patients. The subjects were 144 consecutive patients (103 men and 41 women, mean age 65.9{+-}9.2 years old) who were scheduled for CABG under elective conditions and who were examined by the same MRI apparatus using the same protocol between November 1998 and March 2001. After routine neurological examination and Mini-Mental State Examination (MMSE) were completed, MRI and MRA were obtained, then the prevalence of abnormalities on MRI and MRA studies and risk factors were evaluated. Cervical carotid artery stenosis with {>=}50% luminal narrowing was detected in 29.2% of the subjects, and that with {>=}75% luminal narrowing was detected in 16.0% of the subjects. Intracranial arterial stenosis showing {>=}50% luminal narrowing was detected in 38.2% of subjects, and that showing {>=}75% luminal narrowing was detected in 19.4% of subjects. Brain infarction was observed in 74.3% of subjects, cerebral deep white matter lesion showing grade 2 or higher on Fazekas classification was observed in 17.4% of the subjects. The characteristics, including possible risk factors of subjects with and without these abnormal findings, were compared. Patients with cervical carotid

  1. Risk factors for cervical carotid and intracranial cerebrovascular lesions in patients undergoing coronary artery bypass grafting. Preoperative evaluation using magnetic resonance imaging and angiography

    International Nuclear Information System (INIS)

    Recently neurologic complications after coronary artery bypass grafting (CABG) have received increasing attention. There is no detailed report about the risk factors for these complications, although stenosis in the cervical and intracranial arteries, especially in Japanese patients, latent ischemic brain lesions and preoperative neurological conditions are related to these events. In this prospective study, we evaluated occlusive lesions in the cervical carotid and intracranial arteries, silent brain infarction and cerebral deep white matter lesion with MRA and MRI in patients scheduled to undergo CABG to determine the prevalence of occlusive diseases in cervical carotid and intracranial arteries, latent ischemic change in the brain in this population and to identify preoperative risk factors for these patients. The subjects were 144 consecutive patients (103 men and 41 women, mean age 65.9±9.2 years old) who were scheduled for CABG under elective conditions and who were examined by the same MRI apparatus using the same protocol between November 1998 and March 2001. After routine neurological examination and Mini-Mental State Examination (MMSE) were completed, MRI and MRA were obtained, then the prevalence of abnormalities on MRI and MRA studies and risk factors were evaluated. Cervical carotid artery stenosis with ≥50% luminal narrowing was detected in 29.2% of the subjects, and that with ≥75% luminal narrowing was detected in 16.0% of the subjects. Intracranial arterial stenosis showing ≥50% luminal narrowing was detected in 38.2% of subjects, and that showing ≥75% luminal narrowing was detected in 19.4% of subjects. Brain infarction was observed in 74.3% of subjects, cerebral deep white matter lesion showing grade 2 or higher on Fazekas classification was observed in 17.4% of the subjects. The characteristics, including possible risk factors of subjects with and without these abnormal findings, were compared. Patients with cervical carotid lesions were

  2. The Interrelationship of Psychosocial Risk Factors for Coronary Artery Disease in a Working Population: Do We Measure Distinct or Overlapping Psychological Concepts?

    OpenAIRE

    Kudielka, Brigitte M.; von Känel, Roland; Gander, Marie-Luise; Fischer, Joachim E.

    2004-01-01

    There is growing evidence that psychosocial factors contribute to the risk of coronary artery disease. Commonly used psychometric scales share several features leading to questions about whether they reflect distinguishable concepts. Study participants were 822 employees of the Augsburg Cohort Study ( mean age 40 years, 89% men). The authors analyzed the interrelationship between the following psychosocial measures by applying Pearson correlations and factor analysis to the Hospital Anxiety a...

  3. Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors

    International Nuclear Information System (INIS)

    The purpose of this study was to examine the volume and the composition of atherosclerotic plaque in symptomatic carotid arteries and to investigate the relationship between these plaque features and the severity of stenosis and the presence of cardiovascular risk factors. One hundred patients with cerebrovascular symptoms underwent CT angiography. We measured plaque volume (PV) and the relative contribution of plaque components (calcifications, fibrous tissue, and lipid) in the symptomatic artery. The contribution of different components was measured as the number of voxels within defined ranges of HU values (calcification >130 HU, fibrous tissue 60-130 HU, lipid core <60 HU). Fifty-seven patients had atherosclerotic plaque in the symptomatic carotid artery. The severity of stenosis and PV were moderately correlated. Age and smoking were independently related to PV. Patients with hypercholesterolemia had significantly less lipid and more calcium in their plaques than patients without hypercholesterolemia. Other cardiovascular risk factors were not significantly related to PV or plaque composition. Luminal stenosis of the carotid artery partly reflects the amount of atherosclerotic carotid disease. Plaque volume and plaque composition are associated with cardiovascular risk factors. (orig.)

  4. Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors

    Energy Technology Data Exchange (ETDEWEB)

    Rozie, S.; Weert, T.T. de; Monye, C. de; Homburg, P.J.; Tanghe, H.L.J.; Lugt, A. van der [Erasmus MC, University Medical Center Rotterdam, Departments of Radiology, Rotterdam (Netherlands); Dippel, D.W.J. [Erasmus MC, University Medical Center Rotterdam, Department of Neurology, PO Box 2040, Rotterdam (Netherlands)

    2009-09-15

    The purpose of this study was to examine the volume and the composition of atherosclerotic plaque in symptomatic carotid arteries and to investigate the relationship between these plaque features and the severity of stenosis and the presence of cardiovascular risk factors. One hundred patients with cerebrovascular symptoms underwent CT angiography. We measured plaque volume (PV) and the relative contribution of plaque components (calcifications, fibrous tissue, and lipid) in the symptomatic artery. The contribution of different components was measured as the number of voxels within defined ranges of HU values (calcification >130 HU, fibrous tissue 60-130 HU, lipid core <60 HU). Fifty-seven patients had atherosclerotic plaque in the symptomatic carotid artery. The severity of stenosis and PV were moderately correlated. Age and smoking were independently related to PV. Patients with hypercholesterolemia had significantly less lipid and more calcium in their plaques than patients without hypercholesterolemia. Other cardiovascular risk factors were not significantly related to PV or plaque composition. Luminal stenosis of the carotid artery partly reflects the amount of atherosclerotic carotid disease. Plaque volume and plaque composition are associated with cardiovascular risk factors. (orig.)

  5. El síndrome de Burnout como factor de riesgo en la enfermería:detección y prevención (revisión bibliográfica)

    OpenAIRE

    Leonardo Díez, María Montserrat

    2015-01-01

    La enfermería se describe como una profesión vocacional, de ayuda y cuidados con elevados niveles de responsabilidad, en la que las relaciones interpersonales y las exigencias sociales juegan un importante papel. Por lo que se transcribe no sólo como una profesión agotadora físicamente sino también emocionalmente; dichos factores la engloban como el marcaje perfecto del conocido estrés laboral crónico o síndrome de burnout. Este síndrome se define como aquel cansancio emocional, consecuencia ...

  6. Los grupos de socialización como factor protector contra la depresión en personas ancianas: Baranquilla, Colombia

    Directory of Open Access Journals (Sweden)

    Tuesca-Molina Rafael

    2003-01-01

    Full Text Available Fundamento: La depresión en personas ancianas es un problema de salud pública dada su prevalencia y comorbilidad. Los objetivos de este trabajo son determinar el papel de los grupos de socialización como factor protector para depresión; determinar otros factores socioculturales asociados; estimar la prevalencia y determinar la concordancia de las pruebas de cribado para depresión - criterios de la Asociación Americana de Psiquiatría y el test de Hamilton. Método: Estudio descriptivo transversal. Participaron 602 personas ancianas de entre 60 y 94 años (223 varones y 379 mujeres, muestra representativa para la población residente del sur-occidente de Barranquilla, Colombia. Previo consentimiento, se aplicó una encuesta de administración directa. Se estudiaron las variables demográficas, socioeconómicas, limitación física, enfermedades degenerativas, disfunción familiar y dos tests de depresión para determinar la concordancia. Se realizó análisis bivariado entre la depresión y la pertinencia a grupos de socialización al igual que la depresión y otras variables. Se determinó análisis de cribado e índice de Kappa para la concordancia de pruebas. Resultados: La participación en grupos de socialización fue un factor protector de presentar depresión. (OR: 0,5, IC 95%: 0,34-0,73. La prevalencia de depresión fue de 29,9% (IC95%: 21,4%-39,4%, siendo en los varones 32,7%. La concordancia con el test de Kappa fue 0,63. (moderada a buena La sensibilidad fue del 56,1%, (48,5% a 63,4%; la especificidad de 99,3%, (IC95%: 97,8%-99,8% y el valor predictivo positivo del 97,1% ( IC95%: 97,2%-99,3%. Conclusiones: Esta investigación determina factores de riesgo para padecer depresión en ancianos potencialmente modificables. La participación en grupos de socialización es un factor protector. La disfunción familiar de tipo moderado y severo, las limitaciones sensoriales como ceguera y sordera, la soledad, ausencia de vivienda y bajos

  7. Arterial stick

    Science.gov (United States)

    ... the main arteries in the forearm (radial and ulnar arteries). The procedure is done as follows: The ... Arteries also have thicker walls and have more nerves. When the needle is inserted, there may be ...

  8. Study of the expression for apoptosis factors of thyroid cells after arterial embolization to treat hyperthyroidism caused by Graved' disease

    International Nuclear Information System (INIS)

    Objective: To study the expressions of Fas, FasL, Bax,Bcl-2 and P53 in thyroid tissue and to analyzis (Semi-quantitative analysis)the relation between change of apoptosis in thyroid tissues and clinical therapeutic effect after thyroid arterial embolization in treating hyperthyroidism caused by Graves' disease with observation of apoptosis for 3 years. Methods: 15 patients undergone core needle biopsy of the thyroid gland were divided into three groups according to the amount of time elapsed after thyroid arterial embolization: A group, before thyroid arterial embolization, B group, 1 year group (including 7-day subgroup, 3-month subgroup, 6-month subgroup) and C group, 1 year subgroup and mom than 1 year subgroup after arterial embolization. Results: (1) After embolisation, 15 patients' symptoms and signs of hyperthyroidism disappeared or improved greatly with 9 long term released and 6 improved with small amount of ATD maintenance. (2) The positive staining of Fas and FasL located in endochylema and cell-membrane of thyroid tissue from patients treated with transcathter arterial embolization were higher than those not treated with transcathter arterial embolization (P0.05). (4) The positive cell and the staining of P53 in thyroid tissue had significant difference before and after thyroid arterial embolization (P<0.05). Conclusions: The extra-expression and the increased expression of Fas, FasL, Bax, P53 in thyroid tissue of patient with GD treated by thyroid arterial embolization are correlated with the effects of interventional therapy. (authors)

  9. El turismo como factor de reconversión productiva local en la ciudad de Ushuaia,República Argentina

    OpenAIRE

    Noemí Wallingre

    2004-01-01

    El presente trabajo de investigación, realizado a partir del análisis de caso de la ciudad de Ushuaia, Argentina, pretende probar empíricamente y con carácter inédito que el turismo es un factor de reconversión productiva local y que puede constituirse en nueva estrategia para impulsar el desarrollo de aquellas localidades poseedoras de potencial turístico y mejorar la calidad de vida de la comunidad. Para su demostración se incluyó un análisis comparativo entre los factores tradicionales de ...

  10. Factores afectivos y de personalidad como antecedentes del bienestar laboral en profesores españoles y mexicanos

    OpenAIRE

    Francisco A. Laca Arocena; Juan Carlos Mejía Ceballos; Claudia L. Yáñez Velasco; Edwin G. Mayoral Sánchez

    2011-01-01

    Objetivo. El presente estudio empírico intercultural parte de los presupuestos de la psicología del bienestar subjetivo aplicados al ámbito laboral. Con un propósito general comparativo, se estudia, en primer lugar, la relación e influencia de factores de afectividad, personalidad y sociodemográficos en el bienestar laboral de profesores no universitarios de España y México, y posteriormente, se identifica el conjunto de factores que predicen mejor la satisfacción laboral intrínseca. Método. ...

  11. Turismo como instrumento de desarrollo: Una visión alternativa desde factores humanos, sociales e institucionales

    Directory of Open Access Journals (Sweden)

    Ana Isabel Muñoz Mazón

    2012-01-01

    Full Text Available Se da un tácito consenso asumiendo que la actividad turística es un instrumento efi caz y efi ciente de desarrollo económico y social. Sin embargo, a pesar de las frecuentes declaraciones de índole política a tal respecto, es notoria la falta de un marco teórico-práctico de turismo para el desarrollo. Muchas cuestiones clave necesitan un análisis más profundo: (i qué entendemos como desarrollo a estos efectos; (ii cuál es la contribución del turismo a ese desarrollo; y (iii qué formulación y alcance deben tener las políticas turísticas y su gobernanza para que el turismo sea realmente un instrumento de desarrollo. En este artículo se expone un breve análisis-respuesta a estas cuestiones. A la vista de los paradigmas de desarrollo de las últimas décadas (modernización, neoliberalismo, dependencia, y sostenibilidad, se consideran propuestas apoyadas en la Nueva Economía Institucional y la Teoría del Capital Social, y posibles contenidos de la política y gobernanza del turismo vis-à-vis el desarrollo. Se presentan también a este respecto los resultados de la consulta, realizada en 2011, a 60 expertos de 15 países, en los ámbitos académico, profesional y político.

  12. Ankle-Brachial Index as a Prognostic Factor and Screening Tool in Coronary Artery Disease: Does it Work?

    Directory of Open Access Journals (Sweden)

    Zinat Nadia-Hatmi

    2015-10-01

    Full Text Available Background: Given the lack of consistency in the literature regarding the reliability of the ankle-brachial index (ABI as a valid screening tool and an independent risk indicator of cardiovascular events and mortality, we compared it with angiography as a reference standard test.Methods: This case-control study, conducted between 2010 and 2011 in Tehran Heart Center, recruited 362 angiographically confirmed cases of coronary artery disease (CAD and 337 controls. A standard protocol was used to measure the ABI and different CAD risk factors.Results: A low ABI had specificity of 99.7%, positive predictive value of 95.8%, negative predictive value of 49.8%, sensitivity of 64%, likelihood ratio of 24.07, and odds ratio (OR of 22.79 (95%CI: 3.06-69.76. The role of the associated risk factors was evaluated with OR (95%CI, with the variables including gender 3.15 (2.30-4.30, cigarette smoking 2.72 (1.86-3.99, family history 1.72 (1.17-2.51, diabetes 1.66 (1.15-2.4, and dyslipidemia 1.38 (1.02-1.88. In a multivariate model, the following variables remained statistically significantly correlated with CAD [OR (95%CI]: ABI 13.86 (1.78-17.62; gender 3.69 (2.43- 5.58; family history of CAD 2.18 (1.41-3.37; smoking 1.69 (1.08-2.64; age 1.04 (1.02-1.06.Conclusions: A low ABI had specificity of 99.7%; however, because of its low sensitivity (64%, we should consider CAD risk factors associated with a low ABI in order to use it as a first-line screening test.

  13. Diagnosis of coronary artery disease using myocardial perfusion SPECT in patients with diabetes mellitus: analysis of risk factors

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Ji Hyoung; Kang, Seong Min; Bae, Jin Ho; Jeong, Shin Young; Lee, Sang Woo; Yoo, Jeong Soo; Ahn, Byeong Cheol; Lee, Jae Tae [Kyungpook National University, Daegu, (Korea, Republic of)

    2006-06-15

    Diabetes mellitus is a critical disease with higher rates of cardiovascular morbidity and mortality due to myocardial ischemia and infarction. There is growing interest in how to determine high-risk patients who are candidates for screening testing. This study was performed to evaluate the incidence of coronary artery disease (CAD) in diabetic patients detected by Tc-99m MIBI myocardial perfusion SPECT (MPS) and to assess risk factors of CAD and cardiac hard events. 203 diabetic patients (64 male, mean age 64.1 {+-} 9.0 years) who underwent MPS were included between Jan 2000 and July 2004. Cardiac death and nonfatal myocardial infarction (MI) were considered as hard events, and coronary angioplasty and bypass surgery >60 days after testing were considered as soft events. The mean follow-up period was 36 {+-} 18 months. Patients underwent exercise (n=6) or adenosine stress (n=197) myocardial perfusion SPECT. Perfusion defects on MPS were detected in 28.6% (58/203) of the patients. There was no cardiac death but 11 hard events were observed. The annual cardiac hard event rate was 1.1%. In univariate analysis of clinical factors, typical anginal pain, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were significantly associated with the occurrence of hard events. Anginal pain, peripheral vascular disease, and resting ECG abnormality remained independent predictors of nonfatal MIs with multivariate analysis. Abnormal SPECT results were significantly associated with high prevalence of hard events but not independent predictors on uni- and multivariate analyses. patients who were male, had longer diabetes duration (especially over 20 years), peripheral vascular disease, peripheral polyneuropathy, or resting ECG abnormality had higher incidence of CAD. Among clinical factors in diabetic patients, typical angina, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were strong predictors of hard events.

  14. Tumor necrosis factor alpha and alpha-1 antitrypsin gene variants in Serbian pediatric arterial ischemic stroke patients

    Directory of Open Access Journals (Sweden)

    Đorđević Valentina

    2013-01-01

    Full Text Available The etiology of arterial ischemic stroke (AIS in children is complex, and different from that in adults. Although rare, stroke in children is an important cause of mortality and morbidity. There is increasing evidence that genetic factors, including inflammation mediators, have a role in occurrence and outcome of stroke. We have chosen to assess the role of polymorphism -308G/A in the promoter of tumor necrosis factor α (TNFα gene and S and Z mutations in alpha 1-antitrypsin (AAT gene in the etiology of stroke in children. TNFα polymorphism affects plasma levels of this proinflamatory cytokine, and this could contribute to stroke pathology. It has been shown that increased AAT concentration may present a risk for AIS in children. Since S and Z mutations in AAT gene reduce its levels in plasma they could have a protective role in pediatric stroke. In this study twenty six children with AIS and 100 unrelated individuals from Serbian general population were investigated by PCR/RFLP for these gene variations. No statistically significant difference was observed between patients and general population in distribution of genotypes for -308G/A TNFα polymorphism, so its contributory role in the etiology of stroke was not evident in our group of patients. None of the tested AAT gene mutations were found in patients, which is in concordance with the proposed protective role of deficient AAT variants. AIS is a multifactorial disease, with many genes having a modest role in its pathophysiology, so further analyses of their combined effect are needed to elucidate genetic risk factors in the etiology and outcome of stroke in pediatric patients.

  15. Diagnosis of coronary artery disease using myocardial perfusion SPECT in patients with diabetes mellitus: analysis of risk factors

    International Nuclear Information System (INIS)

    Diabetes mellitus is a critical disease with higher rates of cardiovascular morbidity and mortality due to myocardial ischemia and infarction. There is growing interest in how to determine high-risk patients who are candidates for screening testing. This study was performed to evaluate the incidence of coronary artery disease (CAD) in diabetic patients detected by Tc-99m MIBI myocardial perfusion SPECT (MPS) and to assess risk factors of CAD and cardiac hard events. 203 diabetic patients (64 male, mean age 64.1 ± 9.0 years) who underwent MPS were included between Jan 2000 and July 2004. Cardiac death and nonfatal myocardial infarction (MI) were considered as hard events, and coronary angioplasty and bypass surgery >60 days after testing were considered as soft events. The mean follow-up period was 36 ± 18 months. Patients underwent exercise (n=6) or adenosine stress (n=197) myocardial perfusion SPECT. Perfusion defects on MPS were detected in 28.6% (58/203) of the patients. There was no cardiac death but 11 hard events were observed. The annual cardiac hard event rate was 1.1%. In univariate analysis of clinical factors, typical anginal pain, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were significantly associated with the occurrence of hard events. Anginal pain, peripheral vascular disease, and resting ECG abnormality remained independent predictors of nonfatal MIs with multivariate analysis. Abnormal SPECT results were significantly associated with high prevalence of hard events but not independent predictors on uni- and multivariate analyses. patients who were male, had longer diabetes duration (especially over 20 years), peripheral vascular disease, peripheral polyneuropathy, or resting ECG abnormality had higher incidence of CAD. Among clinical factors in diabetic patients, typical angina, peripheral vascular disease, peripheral polyneuropathy, and resting ECG abnormality were strong predictors of hard events

  16. Age as a Risk factor for Atrial Fibrillation and Flutter after Coronary Artery Bypass Grafting

    OpenAIRE

    Prashant Bhave MD; Rod Passman MD, MSCE

    2012-01-01

    Atrial fibrillation affects approximately 3 million people in the United States and creates a huge burden on the health care system, both in terms of morbidity, mortality, and cost.1 The prevalence of atrial fibrillation rises sharply with increases in age. It is estimated that 8% of people above 70 years of age have atrial fibrillation.2-4 Atrial fibrillation has long been recognized as a powerful risk factor for stroke,5 heart failure,6 and mortality.7 Advancing age amplifies the risk of al...

  17. Age as a Risk factor for Atrial Fibrillation and Flutter after Coronary Artery Bypass Grafting

    Directory of Open Access Journals (Sweden)

    Prashant Bhave MD

    2012-02-01

    Full Text Available Atrial fibrillation affects approximately 3 million people in the United States and creates a huge burden on the health care system, both in terms of morbidity, mortality, and cost.1 The prevalence of atrial fibrillation rises sharply with increases in age. It is estimated that 8% of people above 70 years of age have atrial fibrillation.2-4 Atrial fibrillation has long been recognized as a powerful risk factor for stroke,5 heart failure,6 and mortality.7 Advancing age amplifies the risk of all of these sequelae of atrial fibrillation.

  18. Prevalência de hipertensão arterial e fatores associados em estudantes de Ensino Médio de escolas públicas da Região Metropolitana do Recife, Pernambuco, Brasil, 2006 Prevalence of high blood pressure and associated factors in students from public schools in Greater Metropolitan Recife, Pernambuco State, Brazil, 2006

    Directory of Open Access Journals (Sweden)

    Betânia da Mata Ribeiro Gomes

    2009-02-01

    Full Text Available O objetivo deste estudo foi identificar a prevalência de hipertensão arterial sistêmica e fatores associados à saúde em adolescentes, por meio de estudo epidemiológico transversal de base populacional, realizado no período de abril a setembro de 2006, empregando amostragem estratificada segundo porte da escola e turnos. Utilizando-se o questionário Global School-based Student Health Survey, 1.878 estudantes de 29 escolas públicas da Região Metropolitana do Recife, Pernambuco, Brasil, foram investigados quanto a: idade; sexo; índice de massa corporal; consumo de frutas, verduras, álcool e tabaco; e pressão arterial, admitindo os parâmetros da Task Force Report on High Blood Pressure in Children and Adolescent, de 1996, para pressão arterial, do Centers for Disease Control and Prevention para estado nutricional. As prevalências de hipertensão arterial (medida apenas uma vez, sobrepeso e obesidade igualaram-se a 17,3%, 6,9% e 3,7%, respectivamente. Comportaram-se como fatores associados para hipertensão arterial: sexo masculino, obesidade, sobrepeso e falta de atividade física. Concluiu-se que o conhecimento dos fatores associados para hipertensão arterial em adolescentes poderá subsidiar campanhas de educação para a saúde.The aim of this study was to identify the prevalence of systemic arterial hypertension (high blood pressure and associated health factors in adolescents, using a cross-sectional, population-based, epidemiological design from April to September 2006, within a stratified sample according to school size and shift. Using the Portuguese version of the Global School-Based Student Health Survey questionnaire, 1,878 students from 29 public schools in Greater Metropolitan Recife, Pernambuco State, Brazil, were analyzed for: age, gender, body mass index, fruit, vegetable, alcohol, and tobacco consumption, as well as blood pressure, adopting the 1996 Task Force Report on High Blood Pressure in Children and

  19. Condiciones de trabajo en la producción de comidas como factores de riesgo para la enfermedad venosa de miembros inferiores

    Directory of Open Access Journals (Sweden)

    Clarissa Medeiros da Luz Bertoldi

    2007-03-01

    Full Text Available El presente estudio tiene por objetivo identificar los factores que pueden desencadenar o, según el caso, empeorar el desarrollo de enfermedades venosas en los miembros inferiores en operarios de una cocina colectiva, denominada Unidad de Alimentación y Nutrición. Se ha realizado un estudio cualitativo descriptivo de las condiciones de trabajo de los operarios de la cocina del Hospital Universitario de Florianópolis, al sur de Brasil. Se ha utilizado la metodología del Análisis Ergonómico del Trabajo. Como técnicas para la recopilación de datos se han realizado entrevistas con cuestionario aplicado por el observador, evaluación del Índice de Masa Corporal, examen clínico específico, volumetría por desplazamiento de agua de miembros inferiores, observación directa de las actividades desarrolladas en el ambiente de trabajo, con registro de imágenes y utilización de material como podómetro, cronómetro y termo-higrómetro digital. Tras la realización del estudio se ha podido observar la presencia de distintos grados de enfermedad venosa en un 78,57% de los casos, con una variación media para volumetría del 5,13%. Se han encontrado factores de riesgo para enfermedad venosa en el ambiente investigado, tales como, la postura de bipedestación por largos periodos de tiempo, temperatura y humedad elevados, la carga inadecuada de peso y el sobrepeso de los operarios.The present study evaluates which factors may influence the appearance or severity of lower limb venous disease on workers of a Unit of Food Service. A qualitative research, in the form of a case study, was carried out at a hospital Unit of Food Service located in Florianópolis, Santa Catarina, Brazil. The followed methodology was the Ergonomic Analysis of Work. As for data collection, the following were used: interviews and Body Mass Index (BMI assessment; specific clinical examination, water displacement volumetry of the lower extremities, in addition, on site direct

  20. Association between inflammatory factor, lipid peroxidation and total-antioxidant in non-diabetic patients of coronary artery disease

    Directory of Open Access Journals (Sweden)

    fatemeh khaki-khatibi

    2014-02-01

    Full Text Available Introduction: The oxidative stress and inflammation are cooperative events involved in atherosclerosis development. In the present study, we assessed the association ofmalondialdehyde (MDA, antioxidant markers, high sensitive C-reactive protein (HS-CRPand lipid status parameters in non-diabetic patients with coronary artery disease (CAD orvessel heart disease (VHD. Significant risk factors such as diabetes were excluded from thestudy. Methods: Oxidative stress parameters for example MDA, antioxidant markers including:erythrocyte superoxide dismutase (SOD, glutathione peroxidase (GPX, total antioxidant capacity (TAC, inflammation marker and serum lipid status parameters were measured in 120 subjects including 60 CAD patients (non-diabetic with angiographically diagnosed CADand 60 CAD-free subjects as a control group, also diabetic patients with malignancy, renal andliver disease, and other disease were excluded from the study. Results: The serum MDA and HS-CRP levels were increased significantly as compared to thecontrols. However, erythrocyte SOD, GPX activities and TAC level were reduced significantly in patients (non-diabetic (P < 0.05 in all cases. The levels of total cholesterol,triglyceride, and low-density lipoprotein cholesterol (LDL-c were significantly higher andthat of high-density lipoprotein cholesterol (HDL-c was significantly lower than those ofcontrols (P < 0.05 in all cases. Conclusion: The association between oxidative stress parameters, antioxidant markers, theinflammation index and lipid status parameters suggest their involvement in atherosclerosis development that may lead to CAD progression.

  1. Predictive Factors of Downstaging of Hepatocellular Carcinoma Beyond the Milan Criteria Treated with Intra-arterial Therapies

    International Nuclear Information System (INIS)

    This study was designed to analyze the clinical results in patients suitable for liver transplantation with hepatocellular carcinoma (HCC) who exceeded Milan criteria, which underwent intra-arterial therapies (IAT), to determine predictive factors of successful downstaging. A total of 277 consecutive patients with cirrhosis and HCC were treated by IAT (transarterial oily chemoembolization, transarterial chemoembolization, transarterial embolization) in a single center. Eighty patients exceed the Milan criteria. Patients with infiltrative HCC, hypovascular HCC, and portal vein thrombosis were excluded, with a final study population of 48 patients. Tumor response to IAT was evaluated with CT and/or MRI according to modified RECIST criteria. Successful downstaging was defined as a reduction in the number and size of viable tumors to within the Milan criteria, and serum alpha-fetoprotein (AFP) <100 ng/mL, for at least 6 months. Nineteen patients (39 %) had their tumors successfully downstaged; 29 patients (61 %) did not. Multivariate analysis showed that AFP level <100 ng/mL and 3-year calculated survival probability using the Metroticket calculator were the only independent predictors of successful downstaging (p < 0.023 and p < 0.049 respectively). Biological characteristics of HCC as AFP levels <100 ng/mL and high 3-year calculated survival probability may predict a good response to downstage after IAT.

  2. Predictive Factors of Downstaging of Hepatocellular Carcinoma Beyond the Milan Criteria Treated with Intra-arterial Therapies

    Energy Technology Data Exchange (ETDEWEB)

    Bova, Valentina; Miraglia, Roberto, E-mail: rmiraglia@ismett.edu; Maruzzelli, Luigi [Mediterranean Institute for Transplantation and Advanced Specialized Therapies, (ISMETT), Department of Diagnostic and Interventional Radiology (Italy); Vizzini, Giovanni Battista [Mediterranean Institute for Transplantation and Advanced Specialized Therapies, (ISMETT), Department of Hepatology (Italy); Luca, Angelo [Mediterranean Institute for Transplantation and Advanced Specialized Therapies, (ISMETT), Department of Diagnostic and Interventional Radiology (Italy)

    2013-04-15

    This study was designed to analyze the clinical results in patients suitable for liver transplantation with hepatocellular carcinoma (HCC) who exceeded Milan criteria, which underwent intra-arterial therapies (IAT), to determine predictive factors of successful downstaging. A total of 277 consecutive patients with cirrhosis and HCC were treated by IAT (transarterial oily chemoembolization, transarterial chemoembolization, transarterial embolization) in a single center. Eighty patients exceed the Milan criteria. Patients with infiltrative HCC, hypovascular HCC, and portal vein thrombosis were excluded, with a final study population of 48 patients. Tumor response to IAT was evaluated with CT and/or MRI according to modified RECIST criteria. Successful downstaging was defined as a reduction in the number and size of viable tumors to within the Milan criteria, and serum alpha-fetoprotein (AFP) <100 ng/mL, for at least 6 months. Nineteen patients (39 %) had their tumors successfully downstaged; 29 patients (61 %) did not. Multivariate analysis showed that AFP level <100 ng/mL and 3-year calculated survival probability using the Metroticket calculator were the only independent predictors of successful downstaging (p < 0.023 and p < 0.049 respectively). Biological characteristics of HCC as AFP levels <100 ng/mL and high 3-year calculated survival probability may predict a good response to downstage after IAT.

  3. Essential role of nitric oxide in sepsis-induced impairment of endothelium-derived hyperpolarizing factor-mediated relaxation in rat pulmonary artery.

    Science.gov (United States)

    Subramani, Jaganathan; Leo, Marie Dennis Marcus; Kathirvel, Kandaswamy; Arunadevi, Rathinam; Singh, Thakur Uttam; Prakash, Vellanki Ravi; Mishra, Santosh Kumar

    2010-03-25

    Both endothelial nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) are important vasodilators in pulmonary circulation. Sepsis is known to impair endothelium-dependent dilation in the pulmonary vasculature, but the mechanisms are incompletely understood. We have examined the relative contribution of EDHF/NO to the attenuated endothelium-dependent relaxation of pulmonary artery in sepsis, and the role of inducible nitric oxide synthase (iNOS)-derived NO in this mechanism. Sepsis was induced in male adult Wistar rats by caecal ligation and puncture. At 18h after surgery, left and right branches of pulmonary arteries were isolated for tension recording, NO/cyclic guanosine monophosphate (cGMP) measurements, mRNA and protein expressions. Despite a marked decrease in the arterial endothelial nitric oxide synthase (eNOS) mRNA and phosphorylated-eNOS (p-eNOS) protein expressions in sepsis, endothelium-dependent relaxation to acetylcholine (ACh) mediated by NO, acetylcholine-stimulated NO release and tissue cGMP levels were moderately inhibited. Sepsis however abolished the N(G)-Nitro-l-arginine methyl ester (L-NAME)/indomethacin-resistant arterial relaxation (EDHF response) to acetylcholine in this vessel. In vitro treatment of the arterial rings from septic rats with 1400W, a selective inhibitor of iNOS restored the EDHF response, but had no effect on the acetylcholine-induced relaxation mediated by endothelial NO. The functional role of iNOS-derived NO in impairing EDHF-mediated relaxation was coincident with an increased basal NO production, iNOS mRNA and protein expressions in the rat pulmonary artery. In conclusion, the loss of the EDHF response may be primarily responsible for the endothelial dysfunction in sepsis, and its restoration by a selective iNOS inhibitor may improve pulmonary vasodilation. PMID:20035746

  4. LA TECNOLOGÍA DE LA INFORMACIÓN COMO FACTOR COMPETITIVO: UN ESTUDIO EN EL APL COSECHA METAL-MECÁNICO SANTA ROSA/HORIZONTINA, RS, BRASIL

    Directory of Open Access Journals (Sweden)

    Graniel, Gilmar J.

    2011-06-01

    Full Text Available El presente artículo aborda la utilización de la Tecnología de la Información (TI como factor competitivo en un Arreglo Productivo Local (APL Cosecha Metal-Mecánica en el estado de Río Grande del Sur, Brasil y tiene como objetivo buscar la comprensión de como el uso de la TI contribuye al aumento de la competitividad. Para alcanzar este objetivo, fue realizada una investigación en las empresas que componen el APL. Los resultados de la investigación indicaron que las empresas perciben la importancia del uso de la TI, pero que, en la práctica, su utilización es limitada, sobre todo tratándose de la planificación de la TI. Otro de los resultados que se encontró es que las empresas, aunque formen parte del APL, aún no colaboran entre sí, ya sea a través del cambio de informaciones, o a través de Sistemas de Información. Las principales recomendaciones ante estos resultados es que las empresas traten de actuar activamente para el fortalecimiento del APL. En lo que se refiere al uso de la TI se hace necesaria la planificación y la inversión en la adquisición de sistemas integrados para la mejor gerencia de las informaciones, lo cual contribuirá al aumento de la competitividad de las empresas que pertenecen al arreglo.

  5. Percepción de calidad como factor de competitividad de la infraestructura de hoteles en Santa Marta y Barranquilla

    Directory of Open Access Journals (Sweden)

    Carlos Labarcés Ballestas

    2014-01-01

    Full Text Available Los hoteles con categoría cinco estrellas en las ciudades de Barranquilla y Santa Marta tienen un papel determinante en el desarrollo del turismo de la región; la infraestructura de sus instalaciones y el servicio prestado por el personal, son los dos factores determinantes para brindar un servicio de calidad. En este trabajo se abordará el papel que juega la infraestructura de estos hoteles en la percepción de calidad que tienen los clientes, para establecer así el nivel de competitividad e internacionalización que estos presentan. En la primera parte se establece la percepción de los clientes con respecto a las instalaciones, utilizando el modelo HOTELQUAL, seguidamente se estudia la relación existente entre infraestructura y organización en estos hoteles. Por último, se describe la incidencia de la infraestructura y el servicio desde la óptica de los gerentes.Palabras clave: calidad del servicio; competitividad; industria hotelera; infraestructura; turismo.Quality perception as a competitiviness factor within hotels infraestructure in both Santa Marta and Barranquilla citiesAbstractThe five-star hotels in the cities of Barranquilla and Santa Marta have a decisive role in the development of tourism in the region, the infrastructure of their facilities and the service provided by the staff, are the two determinant factors to provide a quality service. In this paper is addressed the role of the infrastructure of these hotels in the perception of quality that customers have, in order to establish the level of competitiveness and internationalization they present. In the first part the customer perception regarding to facilities is established, using the model HOTELQUAL next the relationship between infrastructure and organization in these hotels is studied. Finally, it is described the impact of the infrastructure and the service from the perspective of the managers.Keywords: quality of service; competitiveness; hotel industry

  6. Viscosidade como fator frenador de rotações Viscoelastic substances as a breaking factor of ocular rotations

    Directory of Open Access Journals (Sweden)

    André Augusto Homsi Jorge

    2003-08-01

    Full Text Available OBJETIVO: Determinar se forças de atrito viscoso podem, sob o ponto de vista quantitativo, agir como possíveis promotoras de estabilização ocular com manutenção dos movimentos de rotação, dando noção dos valores necessários para a aplicabilidade no sistema ocular. MÉTODOS: Um modelo mecânico foi elaborado para a medida de forças necessárias para vencer o atrito de uma esfera de alumínio parcialmente mergulhada em um líquido viscoso. Foram testadas soluções de metilcelulose de 1% a 6% (com variação de 0,5% e dois produtos viscoelásticos (Viscoat® e Provisc®. Outra variável foi a área de contato entre a esfera e o líquido viscoso. RESULTADOS: A força encontrada, após correções e descontos apropriados, foi significativa (acima de 5 gf apenas nas soluções de metilcelulose 5,5% e 6% e somente na maior área de contato testada. CONCLUSÃO: Os líquidos viscosos testados aparentemente não são capazes de obter força de atrito suficiente para a estabilização ocular, com exceção das soluções de metilcelulose 5,5% e 6% mas somente na maior área de contato testada (que correspondeu a 26,2% da área total da esfera.PURPOSE: The aim of this study was to find out if the viscous friction forces could, from the quantitative point of view, act as possible promoters of ocular stabilization keeping the rotational movements and give an idea of the necessary amount for the applicability to the ocular system. METHODS: A mechanic model was made to measure the necessary forces to overcome the friction of the aluminium sphere partially kept in a viscous liquid. Methylcellulose solutions at 1% to 6% (with a variation of 0.5% and viscoelastic products (Viscoat® and Provisc® were tested. Another variable was the area of contact between the sphere and the viscous liquid. RESULTS: The force that was found, after appropriate corrections and discounts, was meaningful (over 5 gf only in the of methylcellulose solutions at 5.5% and 6

  7. Anemia materna en el tercer trimestre de embarazo como factor de riesgo para parto pretérmino

    Directory of Open Access Journals (Sweden)

    Loretta Giacomin-Carmiol

    2009-03-01

    Full Text Available Objetivos: Analizar la relación entre la anemia y el parto pretérmino en el Servicio de Obstetricia del Hospital "Dr. Rafael Ángel Calderón Guardia", durante 2006. Materiales y métodos: Estudio de 110 pacientes y 220 controles. Se utilizó el registro estadístico de la sala de partos del Servicio de Obstetricia para la identificación de la muestra. Los criterios de inclusión para el grupo de casos fueron: edad materna mayor o igual a 18 años, edad materna menor de 35 años, primigesta, embarazo mayor de 32 semanas, embarazo único, y recién nacido vivo al momento del parto. Los criterios de exclusión fueron: embarazo complicado por enfermedades médicas crónicas o inducidas por este, antecedente en la historia clínica de sangrado transvaginal durante el primer o segundo trimestre, antecedente en la historia clínica de síntomas que sugirieran infección del tracto urinario o de otro sistema, antecedente en la historia clínica del uso de tabaco, alcohol u otra sustancia ilícita, productos con algún tipo de malformación diagnosticada previo a la labor del parto o durante el nacimiento, parto inducido o cesárea electiva, parto atendido de forma extrahospitalaria, ausencia o registro incompleto de alguna variable de interés. Las pacientes del grupo de control fueron aquellas internadas durante el mismo periodo. Los dos controles para cada caso fueron seleccionados de forma aleatoria, pareados por grupo quinquenal de edad y fecha de la atención del parto. Los criterios de inclusión y exclusión fueron los mismos aplicados al grupo de casos. Se definió como anemia una hemoglobina menor a 11 g/dl. La magnitud de la asociación entre la anemia y el parto pretérmino se evaluó mediante la razón de probabilidades (Odds Ratio Resultados: La hemoglobina promedio de los casos fue de 12,3 g/dl (DS+ 1,2 y la de los controles de 12,9 g/dl (DS+ 1,1; p < 0,001. El hematocrito promedio de los casos fue de 36,2 %(DS+ 3,6 y la de los

  8. Análisis del tiempo quirúrgico como factor de riesgo en cirugía neonatal

    OpenAIRE

    Cañizo López, Agustín del

    2016-01-01

    INTRODUCCIÓN: El recien nacido es un paciente especialmente sensible a la hipotermia, el sangrado y la infección, que a su vez se relacionan con tiempos quirúrgicos prolongados. OBJETIVO: Demostrar si el tiempo quirúrgico y el tiempo total de quirófano son factores de riesgo en cirugía neonatal MATERIAL Y MÉTODOS: Estudio retrospectivo de los neonatos intervenidos en el hospital infantil del Gregorio Marañón entre 2008 y 2011. Se analizan la relación entre tiempo quirúrgico y tiempo total de ...

  9. Relationship between clinical factors and the incidence of toxicity after intra-arterial chemoradiation for head and neck cancer

    International Nuclear Information System (INIS)

    Background and purpose: Concomitant chemoradiation is more and more used for advanced head and neck cancer. It improves local control and survival compared to radiotherapy alone, but goes along with serious toxicity. This study was set up to determine the relationship between patient-, tumour- and treatment-related factors and acute/late toxicity after concomitant chemoradiation. Patients and methods: One hundred and twenty-five consecutive patients with newly diagnosed inoperable stage III and IV head and neck cancer were enrolled for intra-arterial chemoradiation. There were 28 women (22%) and 97 men (78%) and the mean age was 55 years (range 30-80). One hundred and nine patients had stage IV disease (87%), 16 patients (13%) had stage III disease. Statistical analyses were performed to identify an association between factors and acute/late toxicity. Results: There were eight treatment-related deaths (6%). Severe acute toxicity (grade 3-4), mainly mucositis and dysphagia as categorized by the RTOG toxicity criteria, was recorded in 51% of the patients. Leucopenia (grade 3-4) occurred in 39% and aspiration pneumonia in 20% of patients. Tracheotomy was necessary in 15 (12%) patients. Neurological complications during treatment occurred in 3 (2%) patients. Severe late toxicity occurred in 34% of the patients. The most important of these were pneumonia (14%), osteoradionecrosis (9%) and swallowing problems with permanent percutaneous gastrostomy (20%). Statistical analysis did show a significant association between site and severe acute mucositis (p = 0.007), site and osteoradionecrosis (p = 0.014) and age and xerostomia (p = 0.004). Conclusions: Chemoradiation is frequently associated with serious toxicity. Oral cavity tumours and older age are related to acute mucositis/osteoradionecrosis and xerostomia, respectively

  10. Interactions between rs5498 polymorphism in the ICAM1 gene and traditional risk factors influence susceptibility to coronary artery disease.

    Science.gov (United States)

    Sarecka-Hujar, Beata; Zak, Iwona; Krauze, Jolanta

    2009-06-01

    Coronary artery disease (CAD) depends on multiple genetic and environmental factors. Adhesion molecules are markers of endothelium dysfunction. Intercellular adhesion molecule-1 (ICAM-1) interacts with leukocyte integrins and promotes atherosclerotic process at the surface of endothelial cells. The aim of the study was to assess the association between ICAM1 rs5498 polymorphism and CAD and to establish whether there are any interactions between this polymorphism and traditional risk factors in determining the risk of CAD. We studied 191 cases with angiographically documented CAD and 203 controls with no signs of cardiovascular diseases. The ICAM1 polymorphism was genotyped using PCR-RFLP method. Data were analyzed with the STATISTICA 7.1 and EpiInfo 6 softwares. We did not observe significant differences in the distribution of genotypes and alleles of rs5498 between cases and controls. We only found a tendency to a higher prevalence of G allele carriers (AG + GG) in patients compared to controls (68 vs. 64%, P = 0.399). A synergistic effect of G allele carrier-state and smoking that had influenced the risk of CAD [synergy index multiplicative (SIM = 2.09)] was observed. Smoking carriers of G allele compared to non-smoking AA were more prevalent in CAD group (39.8%) than among controls (13.3%, P < 0.0001, OR 4.81). Moreover, there was also a synergistic effect between G allele carrier-state and an elevated level of triacylglycerols (TG) (SIM = 1.28) increasing the risk of CAD. There is a synergistic interaction between rs5498 genotype and smoking that increases the risk of CAD. PMID:19048183

  11. A influência de fatores emocionais sobre a hipertensão arterial The influence of emotional factors on the arterial hypertension

    OpenAIRE

    Fabiana de Cássia Almeida Fonseca; Renata Zumerle Coelho; Rodrigo Nicolato; Leandro Fernandes Malloy-Diniz; Humberto Corrêa da Silva Filho

    2009-01-01

    OBJETIVO: Realizar revisão bibliográfica de artigos que abordam a relação entre hipertensão arterial e fatores emocionais, levando em consideração a relevância do tema. MÉTODOS: Fez-se busca ativa na Biblioteca Virtual em Saúde, na base de dados MedLine (1997-2008), utilizando palavras da língua portuguesa. Os descritores de assunto escolhidos foram "hipertensão" e "doença cardíaca coronária". Em seguida, refinou-se a busca com os termos "hostilidade", "raiva", "ansiedade", "comportamento imp...

  12. Nursing students' work, a risk factor for the consumption of alcohol and other drugs El trabajo del estudiante de enfermería como un factor de riesgo para el consumo de alcohol y otras drogas O trabalho do acadêmico de enfermagem como fator de risco para o consumo de álcool e outras drogas

    Directory of Open Access Journals (Sweden)

    Elias Barbosa de Oliveira

    2008-08-01

    Full Text Available This descriptive, qualitative study aims to describe risk factors, in the work environment, for the consumption of alcohol and other drugs, and also to confirm the importance of protective factors. Interview technique was used with 51 nursing students at the Rio de Janeiro State University, who work in the city's health services. RESULTS: students related work as a risk factor for the consumption of drugs such as alcohol, cigarettes and anxiolytics. We conclude that working with participative methodologies, valuing student's former experiences, family and group life, and individual characteristics are essential in the preventive approach. Attention to protective factors is recommended.Estudio cualitativo descriptivo que tuvo por objetivo describir los factores de riesgo dentro del ambiente laboral para el consumo de alcohol y otras drogas; así como confirmar la importancia de factores de protección. Se utilizó la técnica de entrevista con 51 estudiantes de enfermería de la Universidad del Estado de Río de Janeiro, que se encontraban en los servicios de salud de la ciudad. RESULTADOS: los alumnos consideraron al trabajo como un factor de riesgo para el consumo de alcohol, cigarro y ansiolíticos. Se concluyó que se debe trabajar en la prevención con métodos participativos y valorar las experiencias pasadas de los alumnos, la convivencia familiar y grupal y las características individuales. Fue recomendada especial atención a los factores de protección.Estudo qualitativo descritivo que objetivou descrever os fatores de risco no ambiente de trabalho para o consumo de álcool e outras drogas, e também ratificar a importância dos fatores protetores. Utilizou-se entrevista com roteiro em 51 acadêmicos de enfermagem da Universidade do Estado do Rio de Janeiro que atuam nos serviços de saúde do município. RESULTADOS: os alunos referiram ao trabalho como fator de risco para o consumo de drogas como o álcool, cigarro e ansiol

  13. Diltiazem como alternativa ao betabloqueador na angiotomografia de artérias coronárias Diltiazem as an alternative to beta-blocker in coronary artery computed tomography angiography

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Rochitte

    2012-08-01

    Full Text Available FUNDAMENTO: A redução da frequência cardíaca (FC na angiografia por tomografia das artérias coronarianas (ATCCor é fundamental para a qualidade de imagem. A eficácia dos bloqueadores de cálcio como alternativas para pacientes com contraindicações aos betabloqueadores não foi definida. OBJETIVOS: Comparar a eficácia na redução da FC e variabilidade RR do metoprolol e diltiazem na ATCCor. MÉTODOS: Estudo prospectivo, randomizado, aberto, incluiu pacientes com indicação clínica de ATCCor, em ritmo sinusal, com FC>70bpm e sem uso de agentes que interferissem com a FC. Cinquenta pacientes foram randomizados para grupos: metoprolol IV 5-15 mg ou até FC≤60 bpm(M, e diltiazem IV 0,25-0,60mg/kg ou até FC≤60 bpm (D. Pressão arterial (PA e FC foram aferidas na condição basal, 1min, 3min e 5min após agentes, na aquisição e após ATCCor. RESULTADOS: A redução da FC em valores absolutos foi maior no grupo M que no grupo D (1, 3, 5min, aquisição e pós-exame. A redução percentual da FC foi significativamente maior no grupo M apenas no 1 min e 3 min após início dos agentes. Não houve diferença no 5 min, durante a aquisição e após exame. A variabilidade RR percentual do grupo D foi estatisticamente menor do que a do grupo M durante a aquisição (variabilidade RR/ FC média da aquisição. Um único caso de BAV, 2:1 Mobitz I, revertido espontaneamente ocorreu (grupo D. CONCLUSÃO: Concluímos que o diltiazem é uma alternativa eficaz e segura aos betabloqueadores na redução da FC na realização de angiografia por tomografia computadorizada das artérias coronarianas. (Arq Bras Cardiol. 2012; [online].ahead print, PP.0-0BACKGROUND: Reducing heart rate (HR in CT angiography of the coronary arteries (CTACor is critical to image quality. The effectiveness of calcium channel blockers as alternatives for patients with contraindications to beta-blockers has not been established. OBJECTIVES: To compare the efficacy in the

  14. El consumo inmoderado de alcohol como factor predictor de la persistencia del consumo de tabaco en jóvenes

    OpenAIRE

    Luisa María Sánchez Zamorano; Mauricio Hernández Ávila; Eduardo Lazcano Ponce

    2006-01-01

    OBJETIVO: Evaluar los factores predictores de la persistencia del tabaquismo en jóvenes estudiantes de Morelos, México. MATERIAL Y MÉTODOS: Se analizó la información de un estudio de cohorte (1998-2001) de estudiantes del sistema público de educación del Estado de Morelos, México. La muestra se integró con 3 699 participantes. El análisis se realizó mediante modelos de regresión logística. RESULTADOS: De los 349 jóvenes que en la medición basal fumaban de modo activo, 192 persistieron en la s...

  15. Broadband as a factor of development: a challenge for Mexican digital agenda La banda ancha como factor de desarrollo: un desafío para la agenda digital mexicana

    Directory of Open Access Journals (Sweden)

    Delia CROVI DRUETTA

    2012-02-01

    Full Text Available This article aims to analyze the importance of broadband as a development issue that has been highlighted at regional and international meetings. As a result of these concerns, in 2010 UNESCO and ITU set up the Broadband Digital Development Commision aimed at promoting the use of this resource related to the objectives of development Goals, Mgs, as proposed by the United Nations Development Programme, UNDP. Data is also provided regarding the broadband in Mexico, availability of factors support the view that there exists a digital division in this area and the absence of public policies consider it a factor of development. Working together explains beyond broadband access and positioned as a key player in processes of technological appropriation that encourage social and cultural changes.Este artículo tiene como propósito analizar la importancia de la banda ancha como factor de desarrollo, tema que ha sido puesto de manifiesto en reuniones regionales e internacionales. Producto de estas preocupaciones en 2010 UNESCO y UIT crearon la Comisión de Banda Ancha para el Desarrollo Digital, cuyo objetivo es promover el uso de este recurso vinculándolo con los Objetivos de Desarrollo del Milenio (ODM, propuestos por el Programa de Naciones Unidas para el Desarrollo (PNUD. Se aportan también datos referidos a la banda ancha en México, su disponibilidad, los factores que permiten sostener que existe una brecha digital en esta materia y la ausencia de políticas públicas que la consideren un factor de desarrollo. El trabajo en conjunto explica la banda ancha más allá del acceso y la sitúa como actor fundamental de procesos de apropiación tecnológica que propician cambios sociales y culturales.

  16. Prevalência e fatores de risco na associação entre doença arterial coronariana e aneurisma de aorta Prevalence and risk factors for combined coronary artery disease and aortic aneurysm

    Directory of Open Access Journals (Sweden)

    Carlos Romério Costa Ferro

    2007-01-01

    Full Text Available OBJETIVO: Avaliar a prevalência da doença arterial coronariana (DAC em portadores de aneurisma de aorta (AA, bem como as diferenças relacionadas às diferentes topografias. Descrever os principais fatores de risco para DAC relacionados a esta associação e suas eventuais diferenças de acordo com as diferentes topografias. MÉTODOS: Estudo prospectivo, aberto, não randomizado que avaliou 95 pacientes (62 homens, 33 mulheres, idade 63 ± 11,8 anos com AA. Todos os pacientes, assintomáticos para DAC, possuíam tomografia computadorizada de aorta e angiografia coronariana. De acordo com a topografia do AA, eles foram divididos em três grupos: 1 pacientes com AA torácica (AAT; 2 com AA toracoabdominal (ATA e 3 com AA abdominal (AAA. Foi criado um banco de dados com as informações clínicas e de exames complementares. A análise estatística realizada com o teste t de Student ou análise de variância (ANOVA para as variáveis contínuas e qui-quadrado para as categóricas, sendo considerado p significante quando 70% e 19 (31,6% > 50%. Quinze pacientes (25% eram uniarteriais, 11 (18% biarteriais e 34 (57% triarteriais. CONCLUSÃO: Em portadores de AA a prevalência de DAC assintomática é elevada, principalmente naqueles com AAA. Os resultados deste estudo sugerem a necessidade de uma estratificação diagnóstica para DAC nos portadores de AA, principalmente nos com AAA.OBJECTIVE: To evaluate CAD prevalence in patients with aortic aneurysm, as well as differences related to aneurysm topographies. To describe the primary risk factors for CAD related to this association and their occasional differences according to AA topographies. METHODS: This was an open, prospective, nonrandomized study that evaluated 95 patients (66 men and 33 women, mean age 63 ± 11.8. All patients, asymptomatic for CAD, had undergone aortic CT and coronary angiography. According to the AA topography, they were classified into three groups: 1 patients with thoracic

  17. Aluminum as a risk factor for Alzheimer's disease Aluminio como factor de riesgo para la enfermedad de Alzheimer Alumínio como fator de risco para a doença de Alzheimer

    Directory of Open Access Journals (Sweden)

    Pricilla Costa Ferreira

    2008-02-01

    Full Text Available The purpose of the study was to condense existing scientific evidence about the relation between aluminum (Al exposure and risk for the development of Alzheimer's Disease (AD, evaluating its long-term effects on the population's health. A systematic literature review was carried out in two databases, MEDLINE and LILACS, between 1990 and 2005, using the uniterms: "Aluminum exposure and Alzheimer Disease" and "Aluminum and risk for Alzheimer Disease". After application of the Relevance Test, 34 studies were selected, among which 68% established a relation between Al and AD, 23.5% were inconclusive and 8.5% did not establish a relation between Al and AD. Results showed that Al is associated to several neurophysiologic processes that are responsible for the characteristic degeneration of AD. In spite of existing polemics all over the world about the role of Al as a risk factor for AD, in recent years, scientific evidence has demonstrated that Al is associated with the development of AD.El objetivo del estudio fue condensar la evidencia científica existente entre la exposición al aluminio (Al y el riesgo para el desarrollo de la Enfermedad de Alzheimer (EA, evaluando los efectos para la salud de la población a largo plazo. Una revisión sistemática de la literatura científica existente entre 1990 y 2005, fue realizada en dos bases de datos, MEDLINE y LILACS, utilizando los unitermos: "Aluminium exposure and Alzheimer Disease" y "Aluminium and risk for Alzheimer Disease". Fueron seleccionados 34 trabajos para la investigación, de los cuales 68% establecieron relação entre el Al y la EA, 23,5% no presentaron datos conclusivos y 8,5% no establecieron ninguna relación entre el Al y la EA. A partir de los resultados obtenidos, se verifica que el Al interviene en diversos procesos neurofisiológicos responsables por la degeneración característica de la EA. A pesar de la polémica existente en el médio científico, la evidencia cient

  18. Surgarcane biopolymer patch in femoral artery angioplasty on dogs Membrana de biopolímero de cana-de-açúcar como remendo em arterioplastias femorais de cães

    OpenAIRE

    José Lamartine de Andrade Aguiar; Esdras Marques Lins; Silvio Romero de Barros Marques; Antônio Roberto de Barros Coelho; Renata de Oliveira Rossiter; Roberto José Vieira de Melo

    2007-01-01

    PURPOSE: The objective of this study was to evaluate the use of the sugarcane biopolymer membrane in femoral artery patch angioplasty on dogs. METHODS: Eight dogs were submitted to bilateral femoral artery patch angioplasty with a sugarcane biopolymer membrane patch on one side and e-PTFE patch on the contralateral side. This research was performed at Experimental Surgical Research Laboratory of the Centro de Ciências da Saúde at Universidade Federal de Pernambuco. The dogs were submitted to ...

  19. An abdominal aortic calcification as a RISK FACTOR FOR cardio -cerebral events in patients with peripheral arterial

    OpenAIRE

    V. A. Zelinskiy; M. V. Melnikov; A. Ye. Barsukov; Andreev, V. V.

    2014-01-01

    Background. The patients with abdominal aortic calcification have a high risk of cardiocerebral events, but the pathways of them have not been reported so far. The goal of our study was to assess the structure and function of myocardium and to determine the morphological features of carotid artery atherosclerosis in patients with abdominal aortic calcification.Materials and methods. A total of 167 executive patients with peripheral arterial disease were enrolled in study. The study group incl...

  20. Pharmacological modulation of arterial stiffness.

    LENUS (Irish Health Repository)

    Boutouyrie, Pierre

    2011-09-10

    Arterial stiffness has emerged as an important marker of cardiovascular risk in various populations and reflects the cumulative effect of cardiovascular risk factors on large arteries, which in turn is modulated by genetic background. Arterial stiffness is determined by the composition of the arterial wall and the arrangement of these components, and can be studied in humans non-invasively. Age and distending pressure are two major factors influencing large artery stiffness. Change in arterial stiffness with drugs is an important endpoint in clinical trials, although evidence for arterial stiffness as a therapeutic target still needs to be confirmed. Drugs that independently affect arterial stiffness include antihypertensive drugs, mostly blockers of the renin-angiotensin-aldosterone system, hormone replacement therapy and some antidiabetic drugs such as glitazones. While the quest continues for \\'de-stiffening drugs\\

  1. La metáfora como factor de textualidad en Ensayo sobre la lucidez, de José Saramago. A metáfora como factor de textualidade em Ensaio Sobre a Lucidez de José Saramago The Metaphor as a Textuality Factor in Ensaio Sobre a Lucidez by José Saramago

    Directory of Open Access Journals (Sweden)

    Olívia Maria Figueiredo

    2006-06-01

    Full Text Available La metáfora como factor de textualidad es una reflexión sobre el modo como el sistema de la lengua se operacionaliza en el discurso. En este caso concreto, como es que en la obra literaria Ensayo sobre la lucidez las expresiones idiomáticas (expresiones compósitas son transformadas de nuevo en expresiones metafóricas (expresiones componenciales. La incidencia del análisis se focaliza en la apreciación de cómo la expresión idiomática recupera su energía creadora y el primer impulso que la pone en circulación. Teniendo por fundamento las teorías de la anáfora (ampliada y de la reconceptualización, se muestra que tal reconversión se va haciendo a lo largo de la obra en un proceso de ampliación del enfoque cognitivo de que el recurso a las implicaturas es un trazo necesario para la comprensión de las explicaturas. Es preciso que el lector seleccione el contexto oportuno para entender pertinentemente el sentido comunicado. Y el sentido comunicado no es más que el cuestionamiento de la relación del hombre con el mundo por medio de la amplitud de escenarios metafóricos que sólo la lengua permite instaurar.A Metáfora como Factor de Textualidade é uma reflexão sobre o modo como o sistema da língua se operacionaliza no discurso. Neste caso concreto, como é que na obra literária Ensaio sobre a Lucidez as expressões idiomáticas (expressões compósitas são transformadas de novo em expressões metafóricas (expressões componenciais. A incidência da análise focaliza-se na apreciação de como a expressão idiomática reganha a sua energia criadora e o impulso primeiro que a pôs em circulação. Tendo por fundamento as teorias da anáfora (ampliada e da reconceptualização, mostra-se que tal reconversão se vai fazendo ao longo da obra num processo de ampliação do enfoque cognitivo de que o recurso às implicaturas é um traço necessário para a compreensão das explicaturas. O que é preciso é que o leitor seleccione o

  2. Differences in traditional and non-traditional risk factors with special reference to nutritional factors in patients with coronary artery disease with or without diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Namita P Mahalle

    2013-01-01

    Full Text Available Introduction: There is an increase in awareness about the role of nutritional factors in chronic non-communicable diseases. We therefore conducted this study with an aim to assess the relationship between nutritional factor (vitamin B12 and homocysteine [Hcy] and its association with insulin resistance and inflammatory markers, and differences in traditional and non-traditional risk factors among diabetics and non-diabetics in known cases of coronary artery disease (CAD. Materials and Methods: Three hundred consecutive patients with known coronary disease on coronary angiography, who were >25 years old were included in this study. All cases were interviewed using a questionnaire. Blood samples were analyzed for insulin, vitamin B12, Hcy and inflammatory markers (highly sensitive C-reactive protein [hsCRP], interleukin-6 [IL-6], Tumor necrosis factor-alfa [TNF-α]. Insulin resistance was calculated with homeostasis model assessment of insulin resistance (HOMA-IR. Results: Mean age of the patients was 60.95 ± 12.3 years. Body mass index and waist hip ratio were comparable in both groups. Triglyceride, very low-density lipoprotein and HbA1C were significantly higher and high-density lipoprotein (HDL was significantly lower in patients with diabetes. Patients with diabetes had significantly high levels of IL-6, hsCRP and TNF-α compared with non-diabetic patients. Insulin resistance was twofold higher in diabetic patients. Serum vitamin B12 levels were significantly lower and Hcy was significantly higher in the diabetic group compared with the non-diabetic patients. HbA1C, HOMA-IR and Hcy levels were positively correlated with inflammatory markers in the total study population and in the non-diabetic patients; but, in diabetic patients, HbA1C and Hcy showed this relation. Conclusions: Vitamin B12 deficiency is common in the diabetic population. Hcy levels were higher in diabetics compared with non-diabetics, and were related to glycemic level and

  3. Oral Candida as an aggravating factor of mucositis Induced by radiotherapy; Candida Oral como fator agravante da mucosite radioinduzida

    Energy Technology Data Exchange (ETDEWEB)

    Simoes, Cristiane Araujo; Castro, Jurema Freire Lisboa de; Cazal, Claudia [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de odontologia

    2011-07-01

    Antineoplastic treatment induces some undesirable consequences in head and neck cancer patients. Often, the emergence of major clinical manifestations, such as oral mucositis, results in temporary interruption of the treatment, decreasing the patients' quality of life, and increasing hospital costs. Radio-induced or chemo-induced oral mucositis is possibly aggravated by opportunist fungal infections, which turn the mucositis more resistant to the conventional treatments. Objective: this study aims to identify the presence of Candida sp. as a possible aggravating factor of oral mucositis in patients with head and neck cancer under antineoplastic treatment. Method: all patients with radio- or chemo-induced oral mucositis from the Cancer Hospital of Pernambuco, treated between October 2008 and April 2009, were selected for the study. The prevalence of Candida sp was measured through the cytological analysis of oral mucosa in patients with oral mucositis. The fungal presence was correlated with the mucositis severity. Results: the results showed a positive association between fungal colonization and more several lesions (degrees III and IV of mucositis). Conclusion: The outcomes shown may contribute to a solution for unconventional mucosites, which do not respond to the usual treatment. (author)

  4. El tiempo como factor cultural y su importancia socioeconómica: Estado del arte y líneas futuras

    OpenAIRE

    Cladellas Pros, Ramon

    2009-01-01

    El propósito de este artículo es analizar la concepción económica del tiempo dependiendo de factores históricos y culturales. El artículo se desglosa en una evolución histórica del concepto tiempo (como se ha concebido éste desde la antigüedad hasta hoy), a continuación se analiza el valor económico del tiempo a través de la historia del no tiempo (ocio) y su contextualización cultural (cultura occidental/concepción lineal vs cultural oriental /concepción cíclica); y finalmente en qué estado ...

  5. Expression of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma and effect of transcatheter arterial chemoembolization therapy on plasma vascular endothelial growth factor level

    Institute of Scientific and Technical Information of China (English)

    Xin Li; Gan-Sheng Feng; Chuan-Sheng Zheng; Chen-Kai Zhuo; Xi Liu

    2004-01-01

    AIM: To investigate the expression level of plasma vascular endothelial growth factor (P-VEGF) in patients with hepatocellular carcinoma (HCC) and its relationship with the clinicopathologic characteristics, and to examine the changes of P-VEGF in the course of transcatheter arterial chemoembolization (TACE).METHODS: Peripheral blood samples were taken from 45HCC patients before and 1, 3, 7 d, and 1 mo after TACE.Plasma VEGF level was measured with the quantitative sandwich enzyme-linked immunosorbent assay (ELISA).Twenty patients with benign liver lesions and 17 healthy control subjects were also included in this study.RESULTS: Plasma VEGF levels in HCC patients were significantly elevated as compared to those in patients with benign liver lesions (P = 0.006) and in the normal controls(P = 0.003). Significant differences were observed when P-VEGF was categorized by tumor size (P = 0.006), portal vein thrombosis (P= 0.011), distant metastasis (P= 0.017),arterial-portal vein shunting (P = 0.026), and International Union Against Cancer (UICC) TNM stage (P = 0.044). There was no correlation between plasma level of VEGF and the level of alpha fetoprotein (α-FP) (r = 0.068, P = 0.658) and weakly correlated with the number of platelets (r = 0.312,P = 0.038). P-VEGF levels increased significantly and reached the peak value on the first day after TACE, and then decreased gradually. The change rate of P-VEGF concentration(one month post-TACE/pre-TACE×100%) was correlated with the retention rate of lipiodol oil (rs = 0.494, P = 0.001)and the tumor volume change (rs = 0.340, P = 0.034).The patients who achieved a partial or complete response to TACE therapy showed significantly less pre-treatment P-VEGF than those nonresponders (P = 0.025). A high pretherapeutic P-VEGF level was associated with poor response to treatment (P = 0.018).CONCLUSION: A high pre-treatment P-VEGF level is a useful marker for tumor progression, especially for vascular invasion. TACE increases the

  6. Atherosclerotic plaque volume and composition in symptomatic carotid arteries assessed with multidetector CT angiography; relationship with severity of stenosis and cardiovascular risk factors

    OpenAIRE

    Rozie, S.; de Weert, T. T.; de Monyé, C.; Homburg, P. J.; Tanghe, H L J; Dippel, D W J; van der Lugt, A.

    2009-01-01

    The purpose of this study was to examine the volume and the composition of atherosclerotic plaque in symptomatic carotid arteries and to investigate the relationship between these plaque features and the severity of stenosis and the presence of cardiovascular risk factors. One hundred patients with cerebrovascular symptoms underwent CT angiography. We measured plaque volume (PV) and the relative contribution of plaque components (calcifications, fibrous tissue, and lipid) in the symptomatic a...

  7. Fibroblast growth factor 23 is associated with carotid artery calcification in chronic kidney disease patients not undergoing dialysis: a cross-sectional study

    OpenAIRE

    Nakayama Masaru; Kaizu Yoshiki; Nagata Masaharu; Ura Yoriko; Ikeda Hirofumi; Shimamoto Sho; Kuma Kazuyoshi

    2013-01-01

    Abstract Background Fibroblast growth factor 23 (FGF23) is an important hormone in the regulation of phosphate metabolism. It is unclear whether FGF23 is associated with carotid artery calcification (CAAC) in predialysis patients. The present study aimed to clarify the relationship between FGF23 and CAAC in patients with chronic kidney disease (CKD) who were not on dialysis. Methods One-hundred ninety-five predialysis CKD patients were enrolled in this cross-sectional study. CAAC was assessed...

  8. Carotid artery calcification at the initiation of hemodialysis is a risk factor for cardiovascular events in patients with end-stage renal disease: a cohort study

    OpenAIRE

    Ikeda Hirofumi; Nishida Kanako; Sumida Yoko; Okada Yasushi; Nagata Masaharu; Ura Yoriko; Nakayama Masaru; Kaizu Yoshiki

    2011-01-01

    Abstract Background Vascular calcification has been recognized as a risk factor for cardiovascular (CV) events in patients with end-stage renal disease (ESRD). However, the association of carotid artery calcification (CAAC) with CV events remains unknown. The aim of this study was to elucidate whether CAAC is associated with composite CV events in ESRD patients. Methods One-hundred thirty-three patients who had been started on hemodialysis between 2004 and 2008 were included in this retrospec...

  9. Like father like son? Sons of patients of European or Indian origin with coronary artery disease reflect their parents' risk factor patterns.

    OpenAIRE

    Shaukat, N.; de Bono, D P; Jones, D R

    1995-01-01

    OBJECTIVE--To investigate the extent to which risk factor patterns associated with coronary artery disease (CAD) in patients of Indian origin and in those of North European origin undergoing coronary angiography for suspected angina were reflected in their apparently healthy sons aged 15-30 years. DESIGN--Prospective study in which risk markers were measured in patients of Indian origin and in matched European patients undergoing angiography and in their sons. SETTING--Patients attending a re...

  10. Increasing severity of cardiovascular risk factors with increasing middle cerebral artery stenotic involvement in type 2 diabetic Chinese patients with asymptomatic cerebrovascular disease

    OpenAIRE

    Thomas, GN; Lin, JW; Lam, WWM; Tomlinson, B; Yeung, V; Chan, JCN; Liu, R; Wong, KS

    2004-01-01

    OBJECTIVE: To identify determinants associated with increasing severity of middle cerebral artery (MCA) stenosis in asymptomatic Chinese type 2 diabetic patients with and without MCA stenosis determined using transcranial Doppler. Conventional risk factors contribute to the pathogenesis of ischemic stroke, and differences in the pattern of these may explain the heterogeneity of disease presentation in different populations. In Chinese patients, MCA stenosis is the most commonly identified int...

  11. Risk Factors for Incident Peripheral Arterial Disease in Type 2 Diabetes: Results From the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) Trial

    OpenAIRE

    Althouse, Andrew D.; Abbott, J . Dawn; Forker, Alan D.; Bertolet, Marnie; Barinas-Mitchell, Emma; Thurston, Rebecca C.; Mulukutla, Suresh; Aboyans, Victor; Brooks, Maria Mori; ,

    2014-01-01

    OBJECTIVE The aim of this article was to define risk factors for incidence of peripheral arterial disease (PAD) in a large cohort of patients with type 2 diabetes mellitus (T2DM), overall and within the context of differing glycemic control strategies. RESEARCH DESIGN AND METHODS The Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) randomized controlled trial assigned participants to insulin-sensitizing (IS) therapy versus insulin-providing (IP) therapy. A total...

  12. Effect of Nuclear Factor-kappa B on Vascular Endothelial Growth Factor mRNA Expression of Human Pulmonary Artery Smooth Muscle Cells in Hypoxia

    Institute of Scientific and Technical Information of China (English)

    张焕萍; 徐永健; 张珍祥; 许淑云; 倪望; 陈士新

    2004-01-01

    Summary: In order to investigate the effect of nuclear factor-kappa B (NF-κB) on vascular endothelial growth factor (VEGF) mRNA expression of human pulmonary artery smooth muscle cells (HPASMCs) in hypoxia, the cultured HPASMCs in vitro were stimulated with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB. The NF-κB p65 nuclei positive expression was detected by immunocytochemical technique. The IκBa protein expression was measured by Western blot.RT-PCR was used to detect the VEGF mRNA expression of HPASMCs. The results showed that no significant change was observed in the NF-κB p65 nuclei positive expression of cultured HPASMCs during 6 h-24 h in normoxia, but the levels of NF-κB p65 nuclei positive expression of cultured HPASMCs were significantly increased in hypoxia groups as compared with those in all normoxia groups (P<0.05). The IκBα protein expression of cultured HPASMCs showed no significant change during 6 h-24 h in normoxia, but significantly decreased in hypoxia as comapred with that in normoxia groups (P<0.05). PDTC (1 to 100 μmol/L) could inhibit the VEGF mRNA expression of HPASMCs in a concentration-dependent manner in hypoxia. In conclusion, NF-κB can be partly translocation activated from cytoplasm into nuclei in the cultured HPASMCs under hypoxia. The inhibition of NF-κB activation can decrease the VEGF mRNA expression. h is suggested that the activation of NF-κB is involved in the VEGFmRNA expression of HPASMCs under hypoxia.

  13. Preeclampsia como factor de riesgo independiente para el trastorno por déficit de atención con hiperactividad. Estudio de casos y controles. Bucaramanga, Colombia

    Directory of Open Access Journals (Sweden)

    Yuly Andrea Castellanos-Castellanos

    2014-07-01

    Full Text Available Introducción: El trastorno por déficit de atención e hiperactividad es una condición mental que afecta a niños y adolescentes con prevalencia estimada de 5.3% en la población mundial y en Colombia es de 19-24% en hombres y 10-12% en mujeres. Su etiología es multifactorial, entre ellos se encuentra la hipoxia como factor del medio ambiente uterino; presentándose en entidades como la preeclampsia, donde se ha considerado determinante en el desarrollo del trastorno por déficit de atención e hiperactividad, siendo importante evaluar su asociación. Objetivo: Determinar la asociación entre el diagnóstico trastorno por déficit de atención e hiperactividad y el antecedente perinatal de preeclampsia. Metodología: Estudio de casos y controles retrospectivo de 411 casos de trastorno por déficit de atención e hiperactividad y 404 controles no emparentados sin trastorno ni otros trastornos disruptivos del comportamiento. La evaluación psiquiátrica se hizo entre el 2005–2011, mediante entrevista estructurada que incluyó indagar el antecedente de preeclamsia en el embarazo de cada paciente. Resultados: El antecedente de preeclampsia se presentó en el 3.7% de los pacientes con trastorno por déficit de atención e hiperactividad y en el 5.5% de los controles (OR 0.66, IC95% 0.34 – 1.29; p=0.221. Esta falta de asociación se mantuvo luego de ajustar por género, ser adoptado, haber nacido por cesárea y edad de inicio del trastorno que llevó a consultar al paciente (OR 0.51, IC95% 0.22 – 1.17; p=0.115. Conclusión: El estudio no encontró significancia estadística entre el antecedente de preeclampsia materna y el trastorno por déficit de atención e hiperactividad como factor principalmente asociado en la muestra de pacientes seleccionados.

  14. Release of soluble vascular endothelial growth factor receptor-1 (sFlt-1 during coronary artery bypass surgery

    Directory of Open Access Journals (Sweden)

    Orsel Isabelle

    2007-09-01

    Full Text Available Abstract Background This study was conducted to follow plasma concentrations of sFlt-1 and sKDR, two soluble forms of the vascular endothelial growth factor (VEGF receptor in patients undergoing coronary artery bypass graft (CABG surgery with extracorporeal circulation (ECC. Methods Plasma samples were obtained before, during and after surgery in 15 patients scheduled to undergo CABG. Levels of sFlt-1 and KDR levels were investigated using specific ELISA. Results A 75-fold increase of sFlt-1 was found during cardiac surgery, sFlt-1 levels returning to pre-operative values at the 6th post-operative hour. In contrast sKDR levels did not change during surgery. The ECC-derived sFlt-1 was functional as judge by its inhibitory effect on the VEGF mitogenic response in human umbilical vein endothelial cells (HUVECs. Kinetic experiments revealed sFlt-1 release immediately after the beginning of ECC suggesting a proteolysis of its membrane form (mFlt-1 rather than an elevated transcription/translation process. Flow cytometry analysis highlighted no effect of ECC on the shedding of mFlt-1 on platelets and leukocytes suggesting vascular endothelial cell as a putative cell source for the ECC-derived sFlt-1. Conclusion sFlt-1 is released during CABG with ECC. It might be suggested that sFlt-1 production, by neutralizing VEGF and/or by inactivating membrane-bound Flt-1 and KDR receptors, might play a role in the occurrence of post-CABG complication.

  15. Peripheral Arterial Disease

    Science.gov (United States)

    Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of ... smoking. Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, ...

  16. The role of happyness and optimism as a protector factor of anxiety [El rol de la felicidad y el optimismo como factor protector de la ansiedad

    Directory of Open Access Journals (Sweden)

    Pablo Vera Villarroel

    2012-06-01

    Full Text Available In this research have been evaluated protection and risk factors associated with anxiety. 711 people participated, who reporting scales of anxiety, depression, hapyness and optimism, including their socio-demographic background. Results indicate that depression is a risk factor for anxiety state as a feature, data evidenced agreeing with the revised literature, since this variable has been detected in comorbility to anxiety in people from different etharian groups. While happyness turned out as a protective factor for both anxieties. Optimism resulted as protector of the anxiety feature. These results emphasize the necessity of further research with positive and negative as a whole, since this type of studies continue to be scarce.

  17. Volumen sanguíneo intratorácico versus presión arterial de oclusión pulmonar como estimadores de precarga cardíaca en pacientes críticos Intrathoracic blood volume versus pulmonary artery occlusion pressure as estimators of cardiac preload in critically ill patients

    Directory of Open Access Journals (Sweden)

    Vinko Tomicic F

    2005-06-01

    Full Text Available Background:Monitoring of cardiac preload by determination of pulmonary artery occlusion pressure (PAOP has been traditionally used to guide fluid therapy to optimize cardiac output (CO. Since factors such as intrathoracic pressure and ventricular compliance may modify PAOP, volumetric estimators of preload have been developed. The PiCCO system is able to measure CO and intrathoracic blood volume (ITBV by transpulmonary thermodilution. Aim: To compare a volumetric (ITBV versus a pressure (PAOP determination to accurately estimate cardiac preload in severely ill patients. Patients and Methods: From June 2001 to October 2003, 22 mechanically ventilated patients with hemodynamic instability underwent hemodynamic monitoring with pulmonary artery catheter (PAC and PiCCO system. ITBV index (ITBVI, PAOP and CI were measured simultaneously by both methods. One hundred thirty eight deltas (D were obtained from the difference of ITBVI, PAOP, CI-PAC and CI-PiCCO between 6-12 am and 6-12 pm. Linear regression analysis of DITBVI versus Ð CI-PiCCO and Ð PAOP versus DCI-PAC were made. Results: Mean age of patients was 60.8 ± 19.4 years. APACHE II was 23.9 ± 7. Fifteen patients met criteria for acute respiratory distress syndrome (ARDS. Delta ITBVI significantly correlated with DCI-PiCCO (r=0.54; 95% confidence interval = 0.41-0.65; p <0.01. There was no correlation between DPAOP and DCI-PAC. Conclusion: ITBVI correlated better with CI than PAOP, and therefore it seems to be a more accurate estimator of preload in unstable, mechanically ventilated patients

  18. Conocimientos que tienen los alumnos de enfermería de la hipertensión arterial.

    OpenAIRE

    Rojas Alcántara, Purificación; Campos Aranda, Matilde; Campoy Moreno, J.; González Guardiola, Mª.D.; Hernández Mendoza, E.; González Quijano, A.; Muñoz Pérez, G.

    2005-01-01

    Los conocimientos que sobre la hipertensión arterial pueden tener las enfermeras en el desarrollo de su actividad profesional tienen una gran importancia, dada su responsabilidad en este campo, tanto en la prevención de los factores de riesgo, realizando educación sanitaria, como en el control de la presión arterial y en los cuidados, cuando se producen complicaciones. En este trabajo pretendemos profundizar en los conocimientos de los alumnos de enfermería, como futur...

  19. Hipertensión arterial y auriculoterapia

    Directory of Open Access Journals (Sweden)

    José Ramón Martínez Pérez

    2015-05-01

    Full Text Available La hipertensión arterial es uno de los principales factores de riesgo cardiovascular; la tendencia mundial al incremento de la expectativa de vida ha propiciado un tránsito mayor al envejecimiento y simultáneamente un incremento de su prevalencia. Las evidencias científicas para apoyar la efectividad de la auriculoterapia en el tratamiento de esta enfermedad resultan aparentemente insuficientes, por lo que muchos profesionales de la salud la desestiman, lo que dio motivo a realizar un trabajo de revisión de la literatura científica, con el objetivo de abordar aspectos relacionados con la aplicación de la auriculoterapia en el tratamiento de la hipertensión arterial, así como esclarecer los mecanismos a través de los cuales reduce la presión sanguínea. Se encontró que en la genesis de la hipertensión arterial intervienen lesiones por plenitud calurosa, o exceso de Yang de hígado, y por calor por vacío, o deficiencia del Yin de riñón. El efecto corrector de la auriculoterapia sobre la hipertensión arterial se explica a través de mecanismos neurológicos, humorales y bioeléctricos que producen sedación, vasodilatación, diuresis e hipotensión; entre los puntos de la auriculopuntura más utilizados en el tratamiento de la hipertensión arterial se incluyen: shenmen auricular, hipertensión arterial 1 y 2, corazón e hígado. Se hacen algunas consideraciones sobre el tema

  20. Factores de riesgo como pronóstico de padecer cáncer de mama en un estado de México Risk factors in the development of breast cancer, state of mexico

    OpenAIRE

    M.ª J. Aguilar Cordero; M. Neri Sánchez; C. A. Padilla López; M. L. Pimentel Ramírez; A. García Rillo; A. M. Sánchez López

    2012-01-01

    Introducción: El cáncer de mama es una de las patología más frecuentes de la mujer y con gran impacto en la sociedad. Los factores de riesgo más estudiados han sido los hormonales, los genéticos y los ambientales, aunque también los hábitos tóxicos, el sobrepeso y la obesidad; como factores protectores, por el contrario, la lactancia materna y la actividad física. Objetivo: Conocer los factores de riesgo de las mujeres con cáncer de mama en nuestro grupo de estudio. Material y métodos: Se rea...

  1. El cambio de las concepciones docentes como factor de la revolución educativa. The change of the educational conceptions like factor of the educational revolution

    Directory of Open Access Journals (Sweden)

    Pozo Juan Ignacio

    2008-07-01

    Full Text Available El constante desarrollo de la realidad social obliga al cambio de modelos pedagógicos para la enseñanza en las escuelas, que aunque son estructurados por teóricos de la educación, la mayoría de las veces no logran pernear las Instituciones Educativas En esta conferencia, el autor resume sus experiencias y los resultados de una investigación realizada en la Universidad de Autónoma de Madrid en asocio con la Universidad de Comahue, en Argentina, en la que se plantea el modelo constructivista como el gran prototipo a seguir, enfrentándolo con la realidad de la escuela, sus docentes y alumnos. Pozo recuerda que en el modelo constructivista la función de la escuela es brindar a los estudiantes una enseñanza dirigida a formar capacidades de aprendizaje, a ordenar el flujo informativo al que se enfrentan en la vida diaria, y a brindarles varios enfoques teóricos para que sean capaces de dudar de ellos y de entender porque esos saberes son mejores que otros; pero aunque muchos docentes conocen y coinciden con las ideas del modelo, no logran aplicarlas en las aulas porque no superan sus teorías implícitas -aquellas que están guardadas en el subconsciente y que son las que realmente guían el accionar de las personas-. Lo mismo sucede con los estudiantes, quienes pese a exigir un cambio de modelo siguen con fuertes raíces hacia los modelos antiguos, que se refleja en la cultura escolar y en las actividades de enseñanza y aprendizaje. The constant development of the social reality forces at the rate of pedagogic models for the education in the schools, that though they are constructed for theoretical of the education, the majority of the times do not achieve the Educational Institutions strike. In this conference, the author summarizes his experiences and the results of an research realized in the University of Autonomous of Madrid in I associate with Comahues University, in Argentina, In that the model appears constructivista as the great

  2. The relation between coronary artery calcification in asymptomatic subjects and both traditional risk factors and living in the city centre: a DanRisk substudy

    DEFF Research Database (Denmark)

    Lambrechtsen, Jess; Gerke, Oke; Egstrup, Kenneth;

    2012-01-01

    Objective:  To evaluate the association between the risk factor of living in the city centre as a surrogate for air pollution and the presence of coronary artery calcification (CAC) in a population of asymptomatic Danish subjects. Design and subjects:  A random sample of 1825 men and women of...... either 50 or 60 years of age were invited to take part in a screening project designed to assess risk factors for cardiovascular disease (CVD). Non-contrast cardiac computed tomography was performed on all subjects and their Agatston scores were calculated to evaluate the presence of subclinical coronary...

  3. Coronary artery bypass grafting in a patient with hemophilia B: continuous recombinant factor IX infusion as per the Japanese guidelines for replacement therapy.

    Science.gov (United States)

    Suzuki, Tomoyuki; Kawamoto, Shunsuke; Kumagai, Kiichiro; Adachi, Osamu; Kanda, Keisuke; Ishikawa, Masaaki; Okitsu, Yoko; Harigae, Hideo; Kurosawa, Shin; Saiki, Yoshikatsu

    2016-08-01

    We herein report our experience of successfully managing the hemostatic system by controlling serum factor IX levels throughout the perioperative period in a patient with hemophilia B. Coronary artery bypass grafting with cardiopulmonary bypass was planned for a 52-year-old man with moderate severity of hemophilia B. During surgery, recombinant factor IX (rFIX; BeneFIX(®) Pfizer Japan inc., Tokyo, Japan) was administered by bolus infusion followed by continuous infusion as per the guidelines of the Japanese Society on Thrombosis and Hemostasis. The operative course was uneventful without any considerable bleeding or complications. PMID:25523881

  4. El acceso al agua como factor de identificación de problemas de desarrollo agrario sostenible en el territorio del Alto Guadiana

    Directory of Open Access Journals (Sweden)

    Ruiz Pulpón, Ángel Raúl

    2008-12-01

    Full Text Available The appropriation of private rights on the use of the water owes to factors of historical and economic type, being delimited and being recognized after the application of the effective legislation at the end of century XXth. The understanding of the social and economic consequences that are derived allows to establishing global frames of reference for the judgment of the environmental problem that considers in territories with problems of sustainable agrarian development, as it has happened with the Guadiana river high basin.

    La apropiación de derechos privados sobre el uso del agua se debe a factores de tipo histórico y económico, siendo delimitados y reconocidos tras la aplicación de la legislación vigente a finales del siglo XX. La comprensión de las consecuencias sociales y económicas que se derivan permite establecer marcos de referencia globales para el enjuiciamiento del problema ambiental que se plantea en territorios con problemas de desarrollo agrario sostenible, tal y como ha ocurrido con la cuenca alta del Guadiana.

  5. Cardiovascular risk factor control and outcomes in peripheral artery disease patients in the Reduction of Atherothrombosis for Continued Health (REACH) Registry

    DEFF Research Database (Denmark)

    Cacoub, Patrice P; Abola, Maria Teresa B; Baumgartner, Iris; Bhatt, Deepak L; Creager, Mark A; Liau, Chiau-Suong; Goto, Shinya; Röther, Joachim; Steg, P Gabriel; Hirsch, Alan T; Iversen, Helle Klingenberg

    2009-01-01

    OBJECTIVES: To examine differences in risk factor (RF) management between peripheral artery disease (PAD) and coronary artery (CAD) or cerebrovascular disease (CVD), as well as the impact of RF control on major 1-year cardiovascular (CV) event rates. METHODS: The REACH Registry recruited >68000...... outpatients aged >or=45 years with established atherothrombotic disease or >or=3 RFs for atherothrombosis. The predictors of RF control that were evaluated included: (1) patient demographics, (2) mode of PAD diagnosis, and (3) concomitant CAD and/or CVD. RESULTS: RF control was less frequent in patients with...... PAD (n=8322), compared with those with CAD or CVD (but no PAD, n=47492) [blood pressure; glycemia; total cholesterol; smoking cessation (each P...

  6. Doença periodontal como potencial fator de risco para síndromes coronarianas agudas Periodontal disease as a potential risk factor for acute coronary syndromes

    Directory of Open Access Journals (Sweden)

    Renata Accarini

    2006-11-01

    .547, meaning that the group with ACS and significant obstructive coronary artery disease was 2.5-fold more likely to have active PD. CONCLUSION: A significant association was found between active periodontal disease and severe obstructive coronary artery in patients with acute coronary syndrome, underscoring the importance of prevention and adequate treatment of periodontal disease, which should be considered as a potential risk factor in the etiology and instability of the atherosclerotic plaque.

  7. El hábito de lectura como factor protector de deterioro cognitivo Reading as a protective factor against cognitive decline

    OpenAIRE

    Miguel Esteve Esteve; Ángel Collado Gil

    2013-01-01

    Objetivo: Determinar si la lectura constituye un factor protector frente al deterioro cognitivo en la población mayor de 65 años. Métodos: Estudio de casos y controles no emparejados. Emplazamiento: Centro de Salud Fuente de San Luis, Valencia, España. Se estudiaron 153 personas mayores de 65 años (51 casos y 102 controles). Se midió el deterioro cognitivo mediante el Miniexamen Cognitivo de Lobo, y el hábito de lectura con la escala de la Federación de Gremios y Editores de España. Resultado...

  8. El hábito de lectura como factor protector de deterioro cognitivo Reading as a protective factor against cognitive decline

    Directory of Open Access Journals (Sweden)

    Miguel Esteve Esteve

    2013-02-01

    Full Text Available Objetivo: Determinar si la lectura constituye un factor protector frente al deterioro cognitivo en la población mayor de 65 años. Métodos: Estudio de casos y controles no emparejados. Emplazamiento: Centro de Salud Fuente de San Luis, Valencia, España. Se estudiaron 153 personas mayores de 65 años (51 casos y 102 controles. Se midió el deterioro cognitivo mediante el Miniexamen Cognitivo de Lobo, y el hábito de lectura con la escala de la Federación de Gremios y Editores de España. Resultados: Mediante regresión logística mostraron asociación significativa el hábito de lectura frecuente durante más de 5 años, los estudios primarios completos y la edad menor de 75 años. Conclusiones: El hábito de lectura es un factor protector de deterioro cognitivo, y la protección es mayor en los lectores frecuentes cuya historia de lectura supera los 5 años.Objective: To determine whether reading is a protective factor against cognitive decline in the population aged over 65 years. Methods: We performed an unmatched case-control study in the Fuente de San Luis Health Center in Valencia, Spain. A total of 153 subjects aged more than 65 years old were studied, corresponding to 51 cases and 102 controls. Cognitive impairment was measured by the version of the Mini-Mental State Examination adapted and validated to Spanish. Reading habits were assessed with the scale of the Federación de Gremios y Editores de España. Results: Logistic regression showed a significant association with the habit of frequent reading for more than 5 years, complete primary school education, and age lower than 75 years. Conclusions: Reading is a protective factor against cognitive impairment. This protection is greater in frequent readers with a history of reading of over 5 years.

  9. Mobility as a territorial key factor in the emission of greenhouse gases; La movilidad como factor territorial dominante en la emision de gases de efecto invernadero

    Energy Technology Data Exchange (ETDEWEB)

    Crespo Garcia, L.; Montane Lopez, M. M.; Garcia Cortes, A.; Jimenez Arroyo, F.

    2011-07-01

    Transport and energy generation are the two dominant sectors in the overall balance of energy consumption, and thus of greenhouse gases emissions. Placement of energy generation plants responds to strategic reasons relate to energy supply in the Spanish territory, while transport is an economic activity tightly related to the productive structure and territorial characteristics: density of populations, geographic situation, efficient space organization, etc. The analysis of these factors enables to prioritize different strategies according the their energetic efficiency in order to pursue an economy less dependent of fossil fuels, focused in activities of higher added value and that keeps in mind limits and strengths of Spanish reality. (Author) 9 refs.

  10. La agresividad en la infancia: el estilo de crianza parental como factor relacionado Aggression in childhood: Parenting style as related factor.

    Directory of Open Access Journals (Sweden)

    Antonio F. Raya

    2009-10-01

    Full Text Available

    El presente estudio se propone analizar la posible relación existente entre la agresividad en los niños medida por sus padres a través del BASC (Sistema de Evaluación de la Conducta de Niños y Adolescentes y el estilo de crianza según el PCRI (Cuestionario de Crianza Parental compuesto por siete factores: apoyo, satisfacción con la crianza, compromiso, comunicación, disciplina, autonomía y distribución de rol, en una muestra de 338 niños (182 niños y 156 niñas entre 3 y 14 años. Los resultados muestran la existencia de una relación significativa entre la agresividad en los niños y la mayoría de los factores del estilo de crianza parental. Además se establece un modelo capaz de predecir el 27% de la varianza con respecto a la agresividad en los niños, compuesto por la disciplina de ambos progenitores, el compromiso y la satisfacción con la crianza de los padres y la autonomía de las madres. Finalmente se discute la utilidad de estos resultados para el planteamiento de estrategias de intervención en el ámbito familiar basadas en el estilo disciplinario.


    Palabras clave: Agresividad, padres, estilo parental, disciplina.
    Aggression

    This current study proposes to analyse the possible relationship which exists between aggression in children reported by parents through the BASC (Behaviour Assessment System for Children, and the parenting style according to the PCRI (Parent-Child Relationship Inventory composed of seven factors such as support, satisfaction with parenting, involvement, communication, limit setting, autonomy granting, and role orientation, in a sample of 338 children (182 male & 156 female between 3 and 14 years old. The results show the existence of a significant relationship between aggression in children and the majority of the parenting factors. Furthermore, a model is established which is able to predict 27% of the variance with respect to aggression in children, made

  11. Síntomas depresivos como factor de riesgo de dependencia en adultos mayores Depressive symptoms as a risk factor for dependence in elderly people

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    José Alberto Ávila-Funes

    2007-10-01

    Full Text Available OBJETIVO: Determinar la relación entre síntomas depresivos y dependencia funcional. MATERIAL Y MÉTODOS: Estudio longitudinal con 1 880 adultos mayores evaluados en 2001 y 2003. Se determinaron los síntomas depresivos con una versión modificada de la Escala de Depresión del Centro de Estudios Epidemiológicos y la dependencia con las escalas de Lawton y Brody, y Katz. La dependencia implicó la asistencia y ayuda para realizar alguna de las actividades interrogadas. Los análisis multifactoriales probaron el nexo entre síntomas depresivos y desarrollo de dependencia. RESULTADOS: En 2001, 37.9% mostró síntomas depresivos. En 2003, 6.1 y 12.7% desarrollaron dependencia para al menos una de las actividades básicas (ABVD e instrumentales de la vida diaria (AIVD, respectivamente. En el análisis multivariado, los síntomas depresivos fueron factor de riesgo sólo para dependencia en las AIVD. CONCLUSIONES: Los síntomas depresivos favorecen el desarrollo de dependencia funcional. Es necesario su reconocimiento sistemático durante la evaluación clínica del adulto mayor.OBJECTIVE: To determine the relationship between depressive symptoms and dependence in activities of daily living. MATERIAL AND METHODS: Participants, aged 70 to 104 (n= 1 880, were evaluated twice (2001 and 2003. Depressive symptoms were established by a modified version of Center for Epidemiologic Studies Depression scale, whereas functional dependence was assessed with Lawton & Brody and Katz scales. Dependence implies the attendance and assistance of another person to accomplish the activity. Multivariate regression analyses were used to determine the effect of depressive symptoms on incident dependence. RESULTS: At baseline, 37.9% had depressive symptoms. After two years, 6.1 and 12.7% developed functional dependence for one or more ADL and IADL, respectively. Multivariate analyses showed that depressive symptoms were a risk factor to the development of functional

  12. La agresividad en la infancia: el estilo de crianza parental como factor relacionado Aggression in childhood: Parenting style as related factor.

    OpenAIRE

    Antonio F. Raya; Mª José Pino; Javier Herruzo

    2009-01-01

    El presente estudio se propone analizar la posible relación existente entre la agresividad en los niños medida por sus padres a través del BASC (Sistema de Evaluación de la Conducta de Niños y Adolescentes) y el estilo de crianza según el PCRI (Cuestionario de Crianza Parental) compuesto por siete factores: apoyo, satisfacción con la crianza, compromiso, comunicación, disciplina, autonomía y distribución de rol, en una muestra de 338 niños (182 niños y 156 niñas) entre 3 y 14 años. L...

  13. Platelet activating factors are associated with depressive symptoms in coronary artery disease patients: a hypothesis-generating study

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    Mazereeuw G

    2015-09-01

    Full Text Available Graham Mazereeuw,1,2,4 Nathan Herrmann,1,5 Hongbin Xu,3,4 Alexandre P Blanchard,3,4 Daniel Figeys,3,4 Paul I Oh,6 Steffany AL Bennett,3,4 Krista L Lanctôt1,2,4–61Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, 2Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; 3Ottawa Institute of Systems Biology and Neural Regeneration Laboratory, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, 4CIHR  Training Program in Neurodegenerative Lipidomics, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, 5Department of Psychiatry, University of Toronto, Toronto, ON, Canada; 6UHN Toronto Rehabilitation Institute, Toronto, ON, CanadaIntroduction: Depression is a frequent complication of coronary artery disease (CAD with an unknown etiology. Platelet activating factor (PAF lipids, which are associated with CAD, have recently been linked with novel proposed etiopathological mechanisms for depression such as inflammation, oxidative/nitrosative stress, and vascular endothelial dysfunction.Methods and results: This hypothesis-generating study investigated the relationships between various PAF species and depressive symptoms in 26 CAD patients (age: 60.6±9.2 years, 69% male, mean Hamilton Depression Rating Scale [HAM-D] score: 11.8±5.2, HAM-D range: 3–20. Plasma PAF analyses were performed using high performance liquid chromatography electrospray ionization mass spectrometry in precursor ion scan. Significant associations between depressive symptom severity (HAM-D score and a greater plasma abundance of the PAFs phosphocholine (PC PC(O-12:0/2:0 (r=0.49, P=0.01, PC(O-14:1/2:0 (r=0.43, P=0.03, PC(O-17:3/2:0 (r=0.44, P=0.04, and PC(O-18:3/2:0 (r=0.50, P=0.01 were observed. Associations between those PAFs and HAM-D score persisted after adjusting for age and sex.Conclusion: These

  14. PHARMACOECONOMIC ANALYSIS OF CARVEDILOL THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AND METABOLIC RISK FACTORS (ACCORDING TO THE CAMELLIA STUDY

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    S. Y. Martsevich

    2016-01-01

    Full Text Available Aim. To perform cost-effectiveness analysis of 24 weeks antihypertensive therapy based on carvedilol or metoprolol in patients with arterial hypertension (HT 1-2 degrees and overweight/obesity. To assess effects of carvedilol therapy on 10-year expected risk of cardiovascular complications (CVC.Material and methods. Patients with HT and overweight/obesity (n=320 were included into the study and randomly split in two groups. Patients of the first group (n=160 received carvedilol as a basic therapy and patients of the second group (n=160 — metoprolol. Both groups of the patients were comparable on key clinical characteristics.Results. In 24 weeks of treatment systolic and diastolic blood pressure (BP decreased significantly in comparison with the baseline level (p<0.0001. Dose doubling of beta-blockers was required more often in patients treated with carvedilol. At the same time a combined antihypertensive therapy of the patients treated with carvedilol was required less (p>0.05. Target BP levels were achieved in carvedilol and metoprolol groups in 96.2and 95.5% of patients respectively (p=0.85. Carvedilol had better effect on plasma metabolic indicators such as glucose (p<0.01, lipid profile, uric acid level. Reduction in expected 10-year risk of death was more pronounced in 24 weeks carvedilol treatment. Cost of target BP level achievement was approximately 2.5 times higher in carvedilol group than this in metoprolol group. However cost of additional therapy was higher in metoprolol group. 1% reduction of the 10-year expected risk of CVC death cost 1 847 rubles in carvedilol therapy.Conclusion. Carvedilol therapy (vs metoprolol one has a higher cost under comparable efficacy. Additional expenses are compensated with the favorable effect on metabolic indices and a more pronounced effect on reduction in the 10-year expected risk of CCO death. That is why carvedilol can be recommended to patients with HT and metabolic risk factors. Longer studies

  15. Disfunção arterial como possível mecanismo de agressão cardíaca em pacientes com diabetes mellitus tipo II. Estudo Doppler-ecocardiográfico

    Directory of Open Access Journals (Sweden)

    Matsubara Beatriz Bojikian

    1997-01-01

    Full Text Available OBJETIVO: Avaliar a estrutura e função do ventrículo esquerdo (VE e a rigidez arterial em portadores de diabetes mellitus tipo II. MÉTODOS: Foram estudados 13 doentes diabéticos de ambos os sexos (55±8 anos sem outras doenças. A estrutura e função do VE foram avaliadas por meio de ecodopplercardiografia associada à monitorização não invasiva da pressão arterial (PA. Os resultados foram comparados aos obtidos em grupo de indivíduos normais de mesma idade (n=12. RESULTADOS: Não houve diferenças entre os grupos quanto a PA diastólica, dimensões das câmaras esquerdas e índices de função sistólica e diastólica. Os pacientes diabéticos apresentaram índice de massa do VE (101±10 vs 80±14g/m²; p<0,001 e índice de rigidez arterial sistêmica (0,86±0,26 vs 0,69±0,19mmHg/mL; p<0,05 significantemente maiores que os controles. CONCLUSÃO: O diabetes mellitus está associado a aumento da rigidez arterial sistêmica e esse fator poderia contribuir para seus efeitos adversos sobre o VE.

  16. Value of systolic pulmonary arterial pressure as a prognostic factor of death in the systemic sclerosis EUSTAR population

    DEFF Research Database (Denmark)

    Hachulla, Eric; Clerson, Pierre; Airò, Paolo; Cuomo, Giovanna; Allanore, Yannick; Caramaschi, Paola; Rosato, Edoardo; Carreira, Patricia E; Riccieri, Valeria; Sarraco, Marta; Denton, Christopher P; Riemekasten, Gabriela; Pozzi, Maria Rosa; Zeni, Silvana; Mihai, Carmen Marina; Ullman, Susanne; Distler, Oliver; Rednic, Simona; Smith, Vanessa; Walker, Ulrich A; Matucci-Cerinic, Marco; Müller-Ladner, Ulf; Launay, David

    2015-01-01

    OBJECTIVE: The aim of this study was to assess the prognostic value of systolic pulmonary artery pressure (sPAP) estimated by echocardiography in the multinational European League Against Rheumatism Scleroderma Trial and Research (EUSTAR) cohort. METHODS: Data for patients with echocardiography d...

  17. Vivir y morir en Madrid: la vivienda como factor determinante del estado de salud de la población madrileña (1874-1923

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    Huertas, Rafael

    2002-12-01

    Full Text Available This paper analyses the role of housing as determining factor for the welfare of Madrid's population during the change of the XIXth century to the XXth century. Through medical reports and the contributions of hygienists and social physicians, it will be demonstrated that unhealthy housing in Madrid became a negative factor for the mortality and the morbidity of its residents, in such a way that it made physicians, town planners, and politicians to be preocupied. It will also be discussed how this problem of unhealthy housing started to take part of the so-called social question and the proposals for intervention always framed within the principles of the liberal hygiene, -which intented to combine public health and town planning politics.

    Se analiza el papel de la vivienda como factor determinante del estado de salud de la población madrileña en el tránsito del siglo XIX al XX. A través de los informes y demás aportaciones de higienistas y médicos sociales, se pone de manifiesto cómo la vivienda insalubre en Madrid incidió de manera negativa en la mortalidad y morbilidad de sus habitantes, siendo motivo de preocupación de médicos, urbanistas y políticos. Se apunta, asimismo, de qué manera el problema de la vivienda insalubre pasa a formar parte de la llamada cuestión social y las propuestas de intervención que, siempre en el marco de los principios de la higiene liberal, intentó aunar actuaciones de salud pública y de política urbanística.

  18. Embarazo adolescente como factor de riesgo para complicaciones obstétricas y perinatales en un hospital de Lima, Perú

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    Javier A. Okumura

    2014-12-01

    Full Text Available Objetivos: analizar el riesgo de complicaciones obstétricas y perinatales en adolescentes embarazadas en un hospital de Lima, Perú. Métodos: estudio de cohorte retrospectiva de 67.693 gestantes atendidas en el período 2000-2010. Se evaluó complicaciones obstétricas y perinatales. Las adolescentes se clasificaron en tardías (15-19 años y tempranas (< 15 años y se compararon con las adultas (20-35 años. Se calculó OR ajustados por educación, estado civil, control prenatal, gestaciones previas, paridad e IMC pregestacional. Resultados: se encontró mayor riesgo de cesárea (OR=1,28; IC95%=1,07-1,53 e infección puerperal (OR=1,72; IC95%=1,17-2,53 en las adolescentes menores de 15 años, así como mayor riesgo (OR=1,34; IC95%=1,29-1,40de episiotomía en las adolescentes tardías. Asimismo, se identificó un menor riesgo del embarazo adolescente para preeclampsia (OR=0,90; IC95%=0,85-0,97, hemorragia de la 2da mitad del embarazo (OR=0,80; IC95%=0,71-0,92, ruptura prematura de membranas (OR=0,83; IC95%=0,79-0,87, amenaza de parto pretérmino (OR=0,87; IC95%=0,80-0,94 y desgarro vaginal (OR= 0,86; IC95%=0,79-0,93. Conclusión: el embarazo se comporta como factor de riesgo para ciertas complicaciones obstétricas en la población adolescente, especialmente en las adolescentes tempranas. Existen además otros factores, que sumados a la edad materna, constituyen la necesidad de formar equipos multidis-ciplinarios para reducir complicaciones obstétricas en esta población.

  19. Comparison of common carotid artery intima-media thickness between Brazilian Euro-descendants and Afro-descendants with atherosclerosis risk factors

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    Ivan Benaduce Casella

    2009-01-01

    Full Text Available OBJECTIVE: To compare common carotid intima-media thickness (IMT between the two major Brazilian ethnic groups (those of African descent and those of European descent among individuals with one or more risk factors for atherosclerotic disease. METHOD: Two hundred and six patients with one or more risk factors for atherosclerotic disease were evaluated in a cross-sectional study in which their clinical, ethnic and Demographic characteristics were collected. All patients underwent duplex ultrasound examination of their carotid vessels to obtain IMT measurements. RESULTS: One hundred and fifty-three patients (74.3% had a carotid IMT greater than 1.0 mm at one or more point of measurement in at least one common carotid artery. There was a significant correlation between older age and mean carotid wall thickness (R=0.479 / P<0.01. Multivariate analysis identified male sex, arterial hypertension and older age as variables associated with increased IMT (P<0.05 for all variables. When IMT was compared between the two ethnic groups in this study, no significant differences were noted. Euro-descendants and Afro-descendants had similar IMT values, even when the groups were stratified by degree of IMT (normal vs. increased and presence of stroke and/or transient ischemic attack (yes vs. no. CONCLUSIONS: The risk factors associated with increased common carotid artery IMT in Brazilian individuals are similar to those in previously described populations. No differences were observed between the two main Brazilian ethnic groups. Longitudinal studies are required for a better evaluation of the incidence, etiologic factors and evolution of carotid intimomedial thickening in this population.

  20. Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer Herpes simplex virus type 1 as risk factor associated to Alzheimer disease

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    Carolina Martin

    2011-06-01

    Full Text Available Herpes simplex virus type 1 (HSV-1 is ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high mortality rate and significant neu-rological, neuropsychological, and neurobehavioral sequels. HSV-1 infects limbic system structures in the central nervous system (CNS, and has been suggested as an environmental risk factor for Alzheimer’s disease. The possibility that HSV-1 reactivates in CNS neurons causing chronic progressive damage at cellular level and altering the neuronal functionality has not been thoroughly investigated. Currently it is ignored if recurrent reactivation of HSV-1 in asymptomatic patients involves some risk of progressive deterioration of the CNS functions caused, in example, by a neuroinflammatory response against the virus or by direct toxicity of the pathogen on neurons. Therefore, studies regarding the routes of dissemination of HSV-1 from the peripheral ganglions to the CNS, as well as the possible cellular and molecular mechanisms implied in generating neuronal damage during latent and productive infection, are of much relevance.

  1. Tomografia por emissão de pósitrons com 18F fluordesoxiglicose como exame não invasivo para o diagnóstico de sarcomas primários de artéria pulmonar 18F-fluorodeoxyglucose positron emission tomography as a noninvasive method for the diagnosis of primary pulmonary artery sarcoma

    Directory of Open Access Journals (Sweden)

    Olívia Meira Dias

    2011-12-01

    Full Text Available Os sarcomas de artéria pulmonar são tumores raros e de difícil diagnóstico, simulando frequentemente o tromboembolismo pulmonar crônico. Relatamos dois casos de pacientes do sexo feminino com quadro clínico de dispneia e massas pulmonares associadas a falhas de enchimento na artéria pulmonar em angiotomografia de tórax. A tomografia por emissão de pósitrons com 18F fluordesoxiglicose mostrou hipercaptação das respectivas lesões. O sarcoma de artéria pulmonar foi confirmado posteriormente por exame anatomopatológico. Ressaltamos a importância do uso desse tipo de tomografia como exame não invasivo no auxílio diagnóstico desses tumoresPulmonary artery sarcomas are rare, difficult-to-diagnose tumors that frequently mimic chronic pulmonary thromboembolism. We report the cases of two female patients with clinical signs of dyspnea and lung masses associated with pulmonary artery filling defects on chest CT angiography. We performed 18F-fluorodeoxyglucose positron emission tomography, which revealed increased radiotracer uptake in those lesions. Pulmonary artery sarcoma was subsequently confirmed by anatomopathological examination. We emphasize the importance of this type of tomography as a noninvasive method for the diagnosis of these tumors

  2. La altitud como factor de riesgo para defectos deL tubo neuraL (DTN Altitude as a risk factor for neural tube defects (NTD

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    Wilmar Saldarriaga

    2007-09-01

    Full Text Available Objetivo: determinar si la altura es un factor de riesgo para defectos del tubo neural (DTN al comparar las prevalencias de defectos del tubo neural entre hospitales que utilizan la metodología del Estudio Colaborativo Latinoamericano de Malformaciones Congénitas (ECLAMC en las ciudades de Cali y Bogotá. Metodología: se realizó un estudio transversal haciendo uso de la base de datos del ECLAMC del Hospital Universitario del Valle (HUV de la ciudad de Cali; Hospital Simón Bolívar, Clínica Emmanuel, Hospital Universitario San Ignacio y Clínica David Restrepo de la ciudad de Bogotá. La población en estudio fue la de los recién nacidos en dichas instituciones entre febrero del 2004 y marzo del 2005. Se estimó la razón de prevalencias entre las ciudades. Resultados: en el HUV de Cali se registraron 7.201 nacimientos entre febrero 2004 y marzo del 2005, dentro de los cuales se identificaron 21 casos de recién nacidos con DTN, para una prevalencia de 29,2 por cada 10.000 nacidos. En Bogotá la suma total de nacimientos registrados en las cuatro instituciones, fue de 15.239, y se identificaron nueve recién nacidos con DTN, para una prevalencia de seis por cada 10.000 nacidos. Se observó una diferencia estadísticamente significativa en general, para todos los DTN (RP: 4,94; 95% IC: 2,26 - 10,78, siendo marcada para anencefalia (RP: 8,46; 95% IC: 1,80 - 39,85 y para espina bífida (RP: 3,81; 95% IC: 1,28 - 11,36. Conclusiones: la prevalencia de los DTN es mayor en ciudades con altitud menor de 2.000 m sobre el nivel del mar, hallazgo acorde con lo reportado en la literatura.Objective: determining whether altitude is a risk factor for neural tube defects by comparing NTD prevalence amongst hospitals in the ECLAMC network in the cities of Cali and Bogotá in Colombia. Methodology: this was a cross-sectional study using ECLAMC databases from the Valle Teaching Hospital in Cali and Hospital Simón Bolívar, Clinica Emmanuel, Hospital

  3. Fatores de risco para doença arterial coronariana em pacientes admitidos em unidade de hemodinâmica Factores de riesgo para enfermedad arterial coronaria en pacientes de una unidad de hemodinamia Risk factors for coronary artery disease in patients admitted in hemodynamics unit

    Directory of Open Access Journals (Sweden)

    Maria Karolina Echer Ferreira Feijó

    2009-12-01

    Full Text Available O estudo transversal objetivou identificar os fatores de risco (FR para doença arterial coronariana (DAC em pacientes submetidos a procedimentos cardíacos em unidade de hemodinâmica. Incluíram-se 302 pacientes com idade de 62±11 anos, predominantemente brancos 270 (89% e do sexo masculino 172 (57%. O FR de maior prevalência foi o sedentarismo 227 (75%, seguido de hipertensão 220 (73%, dislipidemia 150 (50,5%, obesidade 87 (29%, diabetes mellitus 81 (27%, tabagismo 77 (25,5%, consumo de álcool 67 (22% e alimentação pobre em frutas e verduras 15 (5%. A correlação entre o número de FR e as variáveis - escolaridade, renda, idade, estado civil, atividade profissional e sexo -, além do número de procedimentos a que foram submetidos, comparado àqueles que apresentavam número superior a cinco FR para DAC, não foi significativa; no entanto, existe uma associação positiva, reforçando a importância de estratégias que visem à diminuição ou eliminação dos FR modificáveis.Estudio transversal cuyo objetivo fue evaluar la prevalencia de factores de riesgo (FR para enfermedad arterial coronaria (EAC en pacientes sometidos a procedimientos cardíacos en una unidad de hemodinamia. Se incluyeron 302 pacientes de 62±11 años, predominantemente blancos (270, 89% y de sexo masculino (172, 57%. El FR más prevalente fue sedentarismo (227, 75%, seguido de hipertensión (220, 73%, dislipidemia (150, 50.5%, obesidad (87, 29%, diabetes mellitus (81, 27%, tabaquismo (77, 25.5%, consumo de alcohol (67, 22% y alimentación pobre en frutas y verduras (15, 5%. La correlación entre el número de FR y las variables analizadas (escolaridad, salario mínimo, edad, estado civil, actividad profesional y sexo, además del número de procedimientos a los que fueron sometidos comparados con aquellos que presentaban más que cinco FR para EAC, no fue significativo; sin embargo, existe una asociación positiva, reforzando la importancia de estrategias que

  4. Correlation between severity of perfusion abnormalities with clinical symptoms and risk factors for CAD in patients with mild to moderate coronary artery stenosis (50-75%)

    International Nuclear Information System (INIS)

    Full text: Aim: Evaluate the relationship between the severity of perfusion abnormalities, clinical symptoms and risk factors for coronary artery diseases (CAD) in patients with mild to moderate coronary artery stenosis. Material and methods: 136 patents were included in the study, of which 44 with angiographically proven mild to moderate (50-75%) coronary artery stenosis (1st group) and 9 without stenosis (2nd group) from a total of 136 patients who had undergone Tl-201 and Tc99m tetrofosmine myocardial perfusion SPECT and coronary angiography. As a risk factors for CAD we included: hyperlipidaemia, hypertension and diabetes mellitus. As clinical symptom we included chest pain. According myocardial perfusion scintigraphy (MPS) findings of all patients were evaluated according severity of the perfusion defects on MPS and not the extent of them. Results: In the 1st group of patients there is higher incidence of diabetic patients (twice more) and hypertensive (1/3 more) patients than in the second group without CA stenosis. In addition no significant difference was found in the number of patients without risk factors in both groups. The mean number of clinical symptoms for 1 patient in both groups was not statistically significant 1,54 ± 0,24 and 1,25 ± 0,25 respectively, P>0,5. In the 1st group of patients 77,4% of them have reversible myocardial ischemia ,18,1% MI and only 4.5% normal perfusion uptake. Moderate reversible myocardial ischemia was detected in 44.5% of patients of the second group. Comparing the two groups of patients showing moderate reversible myocardial ischemia, (50-75% stenosis and without stenosis), the presence of risk factors was not statistically significant (1,64±0,16 and 1,27±0,32,p-0, 2). Conclusion: No relationship was found between the severity of perfusion abnormalities, clinical symptoms and risk factors of CAD in patients with mild to moderate coronary artery stenosis

  5. Differential Expression of Three Hypoxia-inducible Factor-α Subunits in Pulmonary Arteries of Rat with Hypoxia-induced Hypertension

    Institute of Scientific and Technical Information of China (English)

    Qi-Fang LI; Ai-Guo DAI

    2005-01-01

    Hypoxia inducible transcription factor (HIF)-1α plays an important role in the development of hypoxic pulmonary hypertension, but little is known about HIF-2α and HIF-3α with respect to transcriptional regulation by hypoxia. To examine the expression patterns of all HIF-α subunits (HIF-1α, HIF-2α and HIF-3α) in pulmonary arteries of rats undergoing systemic hypoxia, five groups of healthy male Wistar rats were exposed to normoxia (N) and hypoxia for 3 (H3), 7 (H7), 14 (H14) and 21 (H21) d respectively. Mean pulmonary arterial pressure (mPAP), vessel morphometry and right ventricular hypertrophy index were measured. Lungs were inflation fixed for immunohistochemistry and in situ hybridization, and homogenized for Western blot. mPAP increased significantly after 7 d of hypoxia [(18.4±0.4) vs. (14.4±0.4) mmHg, H7 vs.N], reached its peak after 14 d of hypoxia, then remained stable. Pulmonary artery remodeling and right ventricular hypertrophy developed significantly after 14 d of hypoxia. During normoxia, HIF-1 α and HIF-3α staining were slightly positive regarding mRNA levels. A substantial alteration of HIF-1 α and HIF-3α staining occurred in pulmonary arteries after 14 d and 7 d of hypoxia, respectively, but HIF-2α stainin g showed an inversed trend after 14 d of hypoxia. Protein levels of all HIF-α subunits except HIF-3α showed a marked increase corresponding to the duration of hypoxia, which was obtained by Western blot. Our study found that HIF-1 α, HIF-2α and HIF-3α may not only confer different target genes, but also play key pathogenetic roles in hypoxic-induced pulmonary hypertension.

  6. Hypoxia Inducible Factor-1 Alpha Correlates the Expression of Heme Oxygenase 1 Gene in Pulmonary Arteries of Rat with Hypoxia-induced Pulmonary Hypertension

    Institute of Scientific and Technical Information of China (English)

    Qi-Fang LI; Ai-Guo DAI

    2004-01-01

    To test the hypothesis that hypoxia inducible factor-1 alph (HIF-la) up-regulated theexpression ofheme oxygenase-1(HO-1) gene in pulmonary arteries of rats with hypoxia-induced pulmonaryhypertension, 8 male Wistar rats in each of 5 groups were exposed to hypoxia for 0, 3, 7, 14 or 21d, respectively.Mean pulmonary arterial pressure(mPAP), vessel morphometry and right ventricle hypertrophy index weremeasured. Lungs were inflation fixed for immunohistochemistry, in situ hybridization; frozen for latermeasurement of HO-1 enzyme activity, mPAP increased significantly after 7d of hypoxia [(18.4±0.4)mmHg, P<0.05], reaching its peak after 14d of hypoxia, then remained stable. Pulmonary artery remodelingbecame to develop significantly after 14d ofhypoxia. H1F-1α protein in control was poorly positive (0.05±0.01), but was up-regulated in pulmonary arterial tunica intima of all hypoxic rats. In pulmonary arterialtunica media, the levels of HIF-lα protein were markedly up-regulated after 3d and 7d of hypoxia(0.20±0.02; 0.22±0.02, P<0.05), then declined after 14d and 21d of hypoxia. HIF-1a mRNA stainingwas poorly positive in control, hypoxia for 3 and 7d, but enhanced significantly after 14d of hypoxia(0.20±0.02, P<0.05), then remained stable. HO-1 protein increased after 7d of hypoxia (0.10±0.01,P<0.05), reaching its peak after 14d ofhypoxia (0.21±0.02, P<0.05), then remained stable. HO-1 mRNAincreased after 3d of hypoxia, reaching its peak after 7d of hypoxia (0.17±0.01, P<0.05), then declined.Linear correlation analysis showed that HIF-la mRNA, HO-1 protein and mPAP were associatedwith pulmonary remodeling. HIF-1α protein (tunica intima) was conversely correlated with HIF-1a mRNA(r=0.921, P<0.01), HO-1 protein was conversely correlated with HIF-lα protein (tunica intima)(r=0.821, P<0.01). HIF-1α and HO-1 were both involved in the pathogenesis of hypoxia-induced pulmonaryhypertension in rat. Hypoxia inducible factor-1 alpha correlated the

  7. Hypoxia Inducible Factor-1 Alpha Correlates the Expression ofHeme Oxygenase 1 Gene in Pulmonary Arteries of Ratwith Hypoxia-induced Pulmonary Hypertension

    Institute of Scientific and Technical Information of China (English)

    Qi-FangLI; Ai-GuoDAI

    2004-01-01

    AbstractTo test the hypothesis that hypoxia inducible factor-1 alpha (HIF-1α)up-regulated theexpression of heme oxygenase-1 (HO-1) gene in pulmonary arteries of rats with hypoxia-induced pulmonaryhypertension, 8 male Wistar rats in each of 5 groups were exposed to hypoxia for 0, 3, 7, 14 or 21 d, respectively.Mean pulmonary arterial pressure (mPAP), vessel morphometry and right ventricle hypertrophy index weremeasured. Lungs were inflation fixed for immunohistochemistry, in situ hybridization; frozen for latermeasurement of HO-1 enzyme activity, mPAP increased significantly after 7 d of hypoxia [(18.4 ± 0.4)mmHg, P<0.05], reaching its peak after 14 d of hypoxia, then remained stable. Pulmonary artery remodeling became to develop significantly after 14 d of hypoxia. HIF-1αprotein in control was poorly positive (0.05 ±0.01), but was up-regulated in pulmonary arterial tunica intima of all hypoxic rats. In pulmonary arterialtunica media, the levels of HIF-la protein were markedly up-regulated after 3 d and 7 d of hypoxia(0.20±0.02; 0.22 ± 0.02, P<0.05), then declined after 14 d and 21 d of hypoxia. HIF-mRNA stainingwas poorly positive in control, hypoxia for 3 and 7 d, but enhanced significantly after 14 d of hypoxia(0.20±0.02, P<0.05), then remained stable. HO-1 protein increased after 7 d of hypoxia (0.10±0.01,P<0.05), reaching its peak after 14 d of hypoxia (0.21 0.02, P<0.05), then remained stable. HO-1 mRNA increased after 3 d of hypoxia, reaching its peak after 7 d of hypoxia (0.17 ± 0.01, P<0.05), then declined.Linear correlation analysis showed that HIF-lα mRNA, HO-1 protein and mPAP were associatedwith pulmonary remodeling. HIF-1 α protein (tunica intima) was conversely correlated with HIF-1α mRNA(r=0.921, P<0.01), HO-1 protein was conversely correlated with HIF-1α protein (tunica intima)(r=0.821, P<0.01 ). HIF-1αand HO-1 were both involved in the pathogenesis of hypoxia-induced pulmonaryhypertension in rat. Hypoxia inducible factor-1 alpha

  8. El factor de la percepción de control como determinante en la intención de compra de productos ecológicos

    Directory of Open Access Journals (Sweden)

    María Puelles Gallo

    2014-09-01

    Full Text Available El papel que pueden desempeñar las cadenas de alimentación minorista en el desarrollo de la categoría de productos ecológicos de alimentación es lo que subyace en este trabajo. Se ha comprobado que la teoría del comportamiento planificado -TPB- (Ajzen, 1988, 1991 es aplicable para la medición de la intención de compra hacia productos ecológicos de alimentación bajo la dualidad Marca de Fabricante (MDF vs. Marca de Distribuidor (MDD, y para la detección y diferenciación de los factores que más influyen en la decisión sobre ambos tipos de marca. Se aportan evidencias sobre cómo determinadas acciones de marketing en el punto de venta pueden ser utilizadas como estímulo a la compra de productos ecológicos. Adicionalmente, se ha comprobado que la TPB es aplicable a la evaluación de las diferencias en la actitud hacia la compra de productos ecológicos bajo MDF y bajo MDD. Los resultados muestran que el factor de percepción de control es fundamental en la determinación del comportamiento de compra de estos productos, poniendo de manifiesto, por ejemplo, que una mayor variedad de productos en los lineales, un precio asequible e información adicional sobre las utilidades y beneficios en el punto de venta pueden influir positivamente en el comportamiento de compra.

  9. Historia de obesidad como factor asociado al cáncer de mama en pacientes de un hospital público del Perú

    Directory of Open Access Journals (Sweden)

    José Rojas-Camayo

    2009-07-01

    Full Text Available Realizamos un estudio de casos y controles, en 123 pacientes con diagnóstico de cáncer mamario (casos y 208 pacientes sanas (controles. En la medición se consideró el índice de masa corporal (IMC antiguo (peso promedio de la vida adulta de la persona e IMC actual (peso cuantificado al momento de efectuar la investigación y otros factores de riesgo conocidos. Los IMC antiguos mostraron un riesgo incrementado tanto en mujeres en la premenopausia: sobrepeso OR: 7,29 (IC95%: 1,75 - 30,38 y obesidad OR: 23,43 (IC95%: 2,4 - 229.7; como en mujeres posmenopáusicas: obesidad OR: 3,33 (IC95%: 1,54 - 7,19 y obesidad OR: 6,04 (IC95%: 1,78 - 20,50. Por otro lado, al evaluar el IMC actual, se encontró asociación en las premenopáusicas donde el sobrepeso es un factor protector OR: 0,23 (IC95%: 0,05 - 0,99 y la obesidad no muestra asociación OR: 0,37 (IC95%: 0,08 - 1,8, asimismo, en las posmenopáusicas no se evidenció asociación con el sobrepeso OR: 0,79 (IC95%:0,35 - 1,85 ni con la obesidad OR: 1,19 (IC95%: 0,42 - 3,38. Se concluye que la historia de obesidad está asociada con un incremento de riesgo de cáncer mamario tanto en mujeres premenopáusicas y posmenopáusicas.

  10. Promover en los adolescentes la identificación de sus valores como factores que les protegen de las adicciones: un modelo vivencial centrado en el estudiante

    Directory of Open Access Journals (Sweden)

    María del Pilar GONZÁLEZ FLORES

    2009-05-01

    Full Text Available RESUMEN: En el presente trabajo mostramos una propuesta de intervención surgida de un estudio amplio realizado en la ciudad de Xalapa, Veracruz, México con una muestra representativa de adolescentes no consumidores de sustancias adictivas. Esta propuesta pretende ser una aportación para la identificación y el fortalecimiento de los valores como factor de protección a pesar de la disponibilidad y facilidad de acceso a las drogas en el medio. Diseñamos un programa integral que ayude a los niños y adolescentes no consumidores a mantenerse sin hacer uso de sustancias adictivas, el cual puede ser implementado en las escuelas de educación básica y media. Comprende la fundamentación teórica; destinatarios; objetivos, habilidades, procesos y actitudes a promover; metodología; evaluación; y programa desglosado.ABSTRACT: In this paper we present an intervention offer emerged from a wide study carried out in the city of Xalapa, Veracruz, Mexico with a representative sample of non-consumer of addictive substances teenagers. This proposal is intended to be a contribution for the identification and strengthening of values as a protective factor, despite the availability and easy access to drugs in the environment. We designed a comprehensive program that will help non-consumers children and adolescents to maintain themselves without making any use of addictive substances, which could be implemented in basic and media education schools. It includes the fundamental theory; recipients; objectives, abilities, processes and attitudes to promote; methodology; evaluation; and program breakdown.

  11. Impaired autonomic regulation of resistance arteries in mice with low vascular endothelial growth factor or upon vascular endothelial growth factor trap delivery

    DEFF Research Database (Denmark)

    Storkebaum, Erik; Ruiz de Almodovar, Carmen; Meens, Merlijn; Zacchigna, Serena; Mazzone, Massimiliano; Vanhoutte, Greet; Vinckier, Stefan; Miskiewicz, Katarzyna; Poesen, Koen; Lambrechts, Diether; Janssen, Ger M J; Fazzi, Gregorio E; Verstreken, Patrik; Haigh, Jody; Schiffers, Paul M; Rohrer, Hermann; Van der Linden, Annemie; De Mey, Jo G R; Carmeliet, Peter

    2010-01-01

    BACKGROUND: Control of peripheral resistance arteries by autonomic nerves is essential for the regulation of blood flow. The signals responsible for the maintenance of vascular neuroeffector mechanisms in the adult, however, remain largely unknown. METHODS AND RESULTS: Here, we report that VEGF...

  12. School as a "protective factor" against drugs: perceptions of adolescents and teachers La escuela como "factor protector" para las drogas: una visión de adolescentes y maestros A escola como "fator de proteção" para drogas: uma visão dos adolescentes e professores

    Directory of Open Access Journals (Sweden)

    María del Carmen García de Jesús

    2008-08-01

    Full Text Available This study aims to discover and describe protective factors regarding the use of drugs, according to teachers and students, aged 14 to 15 years, from a Public Secondary School in Santiago de Querétaro, Mexico. This is a descriptive and exploratory study. Data collection was carried out through semi-structure interview and non-participative observation with ten students and five teachers. Three themes resulted from data analysis: school and school's environment: the school does not provide a healthy environment; use of drugs: perceived by both the students and teachers in the institution itself; prevention programs: there are health promotion and prevention programs available at the school. According to the students' and teachers' perceptions, the school represents a risk factor.El presente trabajo tuvo como objetivo conocer y describir los factores protectores en relación con el consumo de drogas, que son considerados por los profesores y alumnos entre 14 y 15 años de edad, de una escuela pública de la ciudad de Santiago de Querétaro, México. Este estudio descriptivo y exploratorio utilizó entrevistas semi-estructuradas y observación no participativa, las cuales fueron aplicadas a 10 alumnos y 5 profesores. Del análisis de los datos surgen tres temáticas: escuela y ambiente escolar: la escuela no favorece un ambiente escolar saludable; consumo de drogas: se observa que tanto los alumnos y maestros consumen drogas en la institución; programas de prevención: la escuela tiene programas de prevención y promoción a la salud, pero no alcanzan a todos los alumnos. Los resultados refieren que la escuela es un factor de riesgo según la visión de profesores y alumnos.O objetivo deste trabalho foi conhecer e descrever os fatores de proteção em relação ao consumo de drogas, considerado por professores e adolescentes, entre 14 e 15 anos de idade, de uma Escola Pública Secundária na cidade de Santiago de Querétaro, México. Este estudo

  13. As condições de trabalho como fator desencadeador do uso de substâncias psicoativas pelos trabalhadores de enfermagem Las condiciones de trabajo como factor desencadenante del uso de sustancias psicoactivas por los trabajadores de enfermería The work conditions as unleash factor of the psychoactive substance use by the workers of nursing

    Directory of Open Access Journals (Sweden)

    Elizabeth Rose Costa Martins

    2007-12-01

    Full Text Available O estudo teve como objeto o uso de substâncias psicoativas pelos trabalhadores de enfermagem e sua relação com o trabalho. O objetivo foi analisar as condições de trabalho como fator desencadeador do uso de drogas pelo trabalhador de enfermagem. O referencial teórico estruturou-se a partir do conceito de drogas e modelos explicativos da drogodependência, apoiados nas concepções de Dejours (1999 e Laurell & Noriega (1989. Estudo descritivo de abordagem qualitativa com 40 sujeitos trabalhadores de enfermagem de clínica médica de um hospital universitário no Município do Rio de Janeiro, realizado em 2005 e 2006. Como instrumento de coleta de dados utilizou-se a entrevista semi-estruturada. Os resultados mostraram que a utilização de substâncias psicoativas pelos profissionais no local de trabalho pode estar relacionada com as condições de sobrecarga de trabalho e com a facilidade de acesso e que tais substâncias comprometem a sua saúde e o desenvolvimento de suas atividades laborais.El estudio tiene como objeto el uso de substancia psicoactivas por los trabajadores de enfermería y su relación con el trabajo. El objetivo fue analizar las condiciones de trabajo como factor desencadenante al uso de drogas por el trabajador de enfermeria. El referencial teórico se estructuró a partir del concepto de drogas y modelos explicativos de la drogodependencia, apoyado en las concepciones de Dejours (1999 y Laurell y Noriega (1989. Estudio descriptivo y enfoque cualitativo con 40 sujetos trabajadores de enfermeria, de clínica médica de un hospital universitário del Municipio de Rio de Janeiro- Brasil, realizado en 2005 y 2006. Como instrumento de recolección de datos, la entrevista semiestructurada. Los resultados revelan que la utilización de substancias psicoactivas, por los profesionales, en el local de trabajo, puede estar relacionada con las condiciones y carga excesiva de trabajo, con la facilidad de acesso y con las

  14. Microglia and macrophages are major sources of locally produced transforming growth factor-beta1 after transient middle cerebral artery occlusion in rats

    DEFF Research Database (Denmark)

    Lehrmann, E; Kiefer, R; Christensen, Thomas;

    1998-01-01

    The potentially neurotrophic cytokine transforming growth factor-beta1 (TGF-beta1) is locally expressed following human stroke and experimental ischemic lesions, but the cellular source(s) and profile of induction have so far not been established in experimental focal cerebral ischemia. This study...... middle cerebral artery. Six hours after ischemia, an early and transient neuronal and microglial expression of TGF-beta1 mRNA was observed in the extraischemic cingulate and frontal cortices. Both early and protracted expression of TGF-beta1 mRNA in the caudate-putamen and neocortical infarcts and in the...

  15. Metabolic Syndrome-Associated Risk Factors and High-Sensitivity C-Reactive Protein Independently Predict Arterial stiffness in 9903 Subjects With and Without Chronic Kidney Disease

    OpenAIRE

    Tsai, Sung-Sheng; Lin, Yu-Sheng; Lin, Chia-Pin; Hwang, Jawl-Shan; Wu, Lung-Sheng; Chu, Pao-Hsien

    2015-01-01

    Abstract Metabolic syndrome (MS), high-sensitivity C-reactive protein (hs-CRP), and chronic kidney disease (CKD) are related to cardiovascular diseases. Although MS is common in CKD subjects, the contribution of MS-associated risk factors and hs-CRP to arterial stiffness in CKD has not been well studied. In this cross-sectional cohort study, we enrolled 9903 subjects who underwent brachial-ankle pulse wave velocity (baPWV) measurements from our database of Health Care Center. CKD was defined ...

  16. Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age

    OpenAIRE

    Rać, Monika Ewa; Suchy, Janina; Kurzawski, Grzegorz; Kurlapska, Agnieszka; Safranow, Krzysztof; Rać, Michał; Sagasz-Tysiewicz, Dagmara; Krzystolik, Andrzej; Poncyljusz, Wojciech; Jakubowska, Katarzyna; Olszewska, Maria; Krupa, Beata; Chlubek, Dariusz

    2011-01-01

    This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age. The study group consisted of 90 patients; the men were ≤ 50 years old and the women were ≤ 55 years old. Amplicons of exons 4 and 5 including fragments of introns were analyzed by DHPLC. Two polymorphisms were found: IVS3-6 T/C (rs3173798) and IVS4-10 G/A (rs3211892). The C allele of the IVS3-6 T/C polymorphism w...

  17. KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor

    OpenAIRE

    Bossini-Castillo, L.; Simeón, Carmen P.; Beretta, L; Broen, Jasper C.; Vonk, Madelon C; Callejas-Rubio, J. L.; Carreira, P; Rodríguez-Rodríguez, Luis; García-Portales, Rosa; González-Gay, M. A.; Castellví, I.; Camps, M T; Tolosa, Carlos; Vicente-Rabaneda, Esther; Egurbide, M V

    2012-01-01

    Introduction: Potassium voltage-gated channel shaker-related subfamily member 5 (KCNA5) is implicated in vascular tone regulation, and its inhibition during hypoxia produces pulmonary vasoconstriction. Recently, a protective association of the KCNA5 locus with systemic sclerosis (SSc) patients with pulmonary arterial hypertension (PAH) was reported. Hence, the aim of this study was to replicate these findings in an independent multicenter Caucasian SSc cohort. Methods: The 2,343 SSc cases...

  18. An abdominal aortic calcification as a RISK FACTOR FOR cardio -cerebral events in patients with peripheral arterial

    Directory of Open Access Journals (Sweden)

    V. A. Zelinskiy

    2014-07-01

    Full Text Available Background. The patients with abdominal aortic calcification have a high risk of cardiocerebral events, but the pathways of them have not been reported so far. The goal of our study was to assess the structure and function of myocardium and to determine the morphological features of carotid artery atherosclerosis in patients with abdominal aortic calcification.Materials and methods. A total of 167 executive patients with peripheral arterial disease were enrolled in study. The study group included 85 patients with abdominal aortic calcification (men – 95.3 %; age median was – 66.6 ± 12. Control group included 82 patients without objective signs of abdominal aortic calcification. Abdominal aortic calcification was detected by CT imaging. All patients have undergone echocardiography and duplex scanning of carotid arteries.Results. Prevalence and severity of ischemic heart disease and cerebrovascular disease were statistically significant higher in patients with abdominal aortic calcification (91.7, 65.8 % vs. 67, 37.3 % (р < 0.01. We have found statistically significant differences between groupsin heart structure and function. A high left ventricular wall thickness (р < 0.01, left atrium dilation (р < 0.01 and enhanced of left ventricular mass (р < 0.05, ejection fraction reduction (р < 0.05 and more common diastolic dysfunction (р < 0.05 were determined inpatients with abdominal aortic calcification. An intima-media thickness of the common carotid artery was significantly higher in study group patients (1.38 ± 0.07 mm vs. 1.14 ± 0.06 mm (р < 0.001.Conclusion. Our findings suggested that abdominal aortic calcification is main reason of hypertrophy and dilation in the left heart due to enhanced peripheral resistance. Hypertrophy and dilation in the left heart is provided a high risk of cardiovascular events in patients withabdominal aortic calcification.

  19. Acute arterial occlusion - kidney

    Science.gov (United States)

    ... arterial thrombosis; Renal artery embolism; Acute renal artery occlusion; Embolism - renal artery ... often result in permanent kidney failure. Acute arterial occlusion of the renal artery can occur after injury ...

  20. A comunicação não-verbal enquanto fator iatrogênico La comunicación noverbal como factor iatrogénico Nonverbal communication as an iatrogenic factor

    Directory of Open Access Journals (Sweden)

    Monica Martins Trovo de Araújo

    2007-09-01

    Full Text Available O estudo teve como objetivo verificar se os enfermeiros identificam situações nas quais os aspectos não-verbais da comunicação interpessoal entre profissionais de saúde e pacientes constituem fator iatrogênico. Os dados foram coletados por meio de entrevista semi-estruturada com oito enfermeiros e analisados segundo a metodologia de análise de conteúdo. Do discurso dos profissionais emergiram três categorias, que evidenciam a percepção da iatrogenia, suas conseqüências e características e a interrelação entre a linguagem não-verbal e o cuidado.El estudio tuvo como objetivo chequear si las enfermeras identifican situaciones en las cuales los aspectos noverbales de la comunicación interpersonal entre los profesionales de la salud y los pacientes, constituyen factor iatrogénico. Los datos habían sido recogidos por medio de entrevistas mitad estructuradas con ocho enfermeras y analizadas de acuerdo con la metodología del análisis del contenido. Del discurso de los profesionales tres categorías habían emergido, que evidencian el factor iatrogénico, sus resultados y características y la interrelación entre la lengua no-verbal y el cuidado.The current study has the purpose of verifying if nurses are able to identify situations in which the nonverbal aspects of interpersonal communication between health professionals and patients constitute an iatrogenic factor. The data were collected through semistructured interviews with eight nurses and were analyzed according to the content analysis methodology. Three categories appeared from the professional discourses, and these categories make evident the perception of iatrogenesis, its consequences and characteristics and the interrelation between non-verbal language and nursing care.

  1. La educación como factor disuasorio en la reincidencia de la conducta delictiva en menores/The education as an inhibitory factor of minor’s criminal behavior

    Directory of Open Access Journals (Sweden)

    José Manuel Rojas Cervantes

    2012-08-01

    Full Text Available La violencia en nuestro país, presenta una tendencia definida de crecimiento, abarcando cada vez más sectores de la población y afectando la percepción que tenemos los mexicanos de nuestra dinámica social. Los menores se involucran en conductas antisociales y comportamientos delictivos con una frecuencia significativamente más alta al paso de los años. Ante este escenario, el presente artículo documenta una intervención realizada en Comunidades para Adolescentes del DF (antes tutelar para menores, que fundamenta una reflexión documental sobre cómo influye como la educación formal y el proyecto de vida de 22 miembros de esta comunidad como factor que disuada la reincidencia de este tipo de comportamientos. Encontrando que si existe influencia significativa en la relación de variables en la parte experimental, y sugiriendo alternativas de tratamiento penitenciario ambulatorio para poder solventar las carencias del sistema penitenciario en general.

  2. Factores de riesgo como pronóstico de padecer cáncer de mama en un estado de México Risk factors in the development of breast cancer, state of mexico

    Directory of Open Access Journals (Sweden)

    M.ª J. Aguilar Cordero

    2012-10-01

    Full Text Available Introducción: El cáncer de mama es una de las patología más frecuentes de la mujer y con gran impacto en la sociedad. Los factores de riesgo más estudiados han sido los hormonales, los genéticos y los ambientales, aunque también los hábitos tóxicos, el sobrepeso y la obesidad; como factores protectores, por el contrario, la lactancia materna y la actividad física. Objetivo: Conocer los factores de riesgo de las mujeres con cáncer de mama en nuestro grupo de estudio. Material y métodos: Se realizó un estudio de casos y controles en 115 mujeres diagnosticadas con cáncer de mama y en 115 mujeres sanas que acudieron al centro Oncológico de ISSEMyM en el periodo enero-diciembre del año 2011. Se recogieron datos sobre la historia familiar de cáncer, de los antecedentes personales, así como de los estilos de vida y de la determinación del Índice de Masa Corporal (IMC. El riesgo fue estimado con modelos multivariados de regresión logística y chi cuadrada. Resultados: Se encontró un riesgo mayor de padecer cáncer de mama a las mujeres con sobrepeso y obesidad, que no desarrollaban ejercicio alguno y con un menor índice de lactancia materna. No se encontraron diferencias significativas entre el cáncer de mama y los hábitos tóxicos. Conclusiones: En nuestro estudio, el cáncer de mama se relaciona con el sobrepeso, la obesidad y la inactividad física. La lactancia materna, practicada durante los primeros meses de vida del bebé, se manifestó como un factor protector de padecer esta enfermedad.Introduction: Breast cancer is one of the most frequent diseases in women today, and its social impact is devastating. The risk factors focused on in recent research are mainly hormonal, genetic, and environmental though toxic habits, overweight, and obesity have also been studied. In contrast, protective factors against breast cancer include breastfeeding and daily exercise. Objective: To ascertain the risk factors for the women with

  3. A variedade da dieta é fator protetor para a pressão arterial sistólica elevada Dietary variety is a protective factor for elevated systolic blood pressure

    Directory of Open Access Journals (Sweden)

    Erick Prado de Oliveira

    2012-04-01

    Full Text Available FUNDAMENTO: A dieta influencia diretamente a hipertensão arterial (HAS, que é um dos principais fatores de risco da doença cardiovascular. OBJETIVO: Associar a HAS com fatores dietéticos de adultos clinicamente selecionados para programa de mudança de estilo de vida. MÉTODOS: Estudo transversal composto por 335 indivíduos, com idade entre 44 e 65 anos, clinicamente selecionados para um programa de mudança de estilo de vida. Foram avaliados os dados antropométricos (IMC, % de gordura e circunferência abdominal, os componentes bioquímicos (concentrações plasmáticas de glicose, triglicerídeos, colesterol total, HDL-c e LDL-c e a dieta, por meio do recordatório de 24 horas. A qualidade da dieta foi avaliada pelo Índice de Alimentação Saudável. A pressão arterial foi mensurada de acordo com a V Diretriz Brasileira de Hipertensão Arterial e classificada de acordo com o NCEP-ATPIII. A regressão logística foi realizada para determinar a probabilidade de alterações na PAS e PAD de acordo com a ingestão dietética. Adotou-se como significante o valor de p BACKGROUND: Diet directly influences systemic arterial hypertension (SAH, which is one of the main risk factors for cardiovascular disease. OBJECTIVE: To associate hypertension with dietary factors in adults clinically selected for a change-of-lifestyle program. METHODS: Cross-sectional study comprising 335 individuals, aged between 44 and 65 years, clinically selected for a change-of-lifestyle program. We evaluated anthropometric data (BMI, %body fat and waist circumference, biochemical components (plasma glucose, triglycerides, total cholesterol, HDL-C and LDL-c and diet, through the 24-hour recall method. The quality of the diet was assessed by the Healthy Eating Index. Blood pressure was measured according to the V Brazilian Guidelines on Hypertension and classified according to NCEP-ATPIII. Logistic regression was performed to determine the likelihood of changes in SBP and

  4. Fatores de risco associados à pressão arterial elevada em adolescentes Risk factors associated with high blood pressure in adolescents

    Directory of Open Access Journals (Sweden)

    Kelly Samara da Silva

    2007-08-01

    Full Text Available Níveis elevados de pressão arterial (PA na infância e adolescência têm sido freqüentemente associados a outros fatores de risco cardiovasculares, além de hipertensão arterial na fase adulta da vida. O presente estudo objetivou identificar fatores de risco associados à PA elevada em adolescentes. Participaram do estudo 674 adolescentes de escolas públicas e privadas, de ambos os sexos (303 rapazes e 371 moças, com idade de 14 a 17 anos (16,5 DP 0,9, da cidade de João Pessoa, Paraíba. Mediante aplicação de um questionário, foram levantadas informações sobre: a indicadores sociodemográficos; b nível de prática da atividade física; c hábitos alimentares; c índice de massa corporal; e fumo e bebidas alcoólicas; e foram realizadas medidas de PA. A prevalência de PA elevada foi de 7,4%, sendo maior nos rapazes (10,2% quando comparada com a das moças (5,1%, p High levels of arterial blood pressure in childhood and adolescence have been often associated with other cardiovascular risk factors apart from arterial hypertension in the adult stage of life. The present study aimed at identifying risk factors associated with high blood pressure in adolescents. The subjects were 674 adolescents from public and private schools in the city of João Pessoa, Paraíba. These subjects were of both sexes (i.e., 303 boys and 371 girls and their ages spanned from 14 to 17 years old. By means of a questionnaire, information about the following aspects was gathered: a socio-demographic status; b physical activity levels; c eating habits; d body mass index; e consumption of alcohol and smoking. Moreover, measurements of arterial pressure (AP showed that the prevalence of high AP was 7.4 %, being higher in boys (10.2% when compared with girls (5.1%, p < 0.01. The results of the multivaried analysis indicated that overweight adolescents displayed from five to six times more chance of having high AP than adolescents with light/normal weight (boys: OR

  5. Estudo comparativo entre efedrina e etilefrina como vasopressor para correção da hipotensão arterial materna em cesarianas eletivas com raquianestesia Estudio comparativo entre efedrina y etilefrina como vasopresor para correción de la hipotensión materna en cesáreas electivas con raquianestesia Ephedrine and etilefrine as vasopressor to correct maternal arterial hypotension during elective cesarean section under spinal anesthesia. Comparative study

    Directory of Open Access Journals (Sweden)

    Sérgio D. Belzarena

    2006-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A efedrina é o vasopressor mais utilizado em obstetrícia e a etilefrina é muito usada em anestesia regional. O objetivo deste estudo foi comparar a efedrina com a etilefrina para correção de hipotensão arterial materna durante raquianestesia para cesariana eletiva. MÉTODO: Foram estudadas 120 gestantes divididas de forma aleatoria em dois grupos iguais. Todas receberam raquianestesia com bupivacaína, fentanil e morfina. Foi medida a pressão arterial não-invasiva e a freqüência cardíaca. Os recém-nascidos foram avaliados com o índice de Apgar. A incidência de hipotensão arterial, a quantidade de vasopressor necessária para correção e os efeitos adversos foram anotados. RESULTADOS: Ocorreu hipotensão arterial materna com freqüência nos dois grupos, sendo 68% do grupo etilefrina e 63% do grupo efedrina. Na maioria das gestantes foi corrigida com a primeira dose do vasopressor, sem diferença entre os grupos (66% etilefrina, 58% efedrina. A hipotensão arterial necessitou de duas ou mais doses de vasopressor para ser corrigida ou houve hipertensão reativa em poucas pacientes (24% e 10% do grupo etilefrina e 34% e 8% do grupo efedrina, respectivamente sem diferença estatística significativa. Não houve diferença nos efeitos adversos e nos testes dos recém-nascidos. CONCLUSÕES: Com o método de administração empregado e com as doses de vasopressor selecionadas não houve diferença entre a efedrina e a etilefrina quando utilizadas para corrigir a hipotensão arterial materna em cesarianas com raquianestesia.JUSTIFICATIVA Y OBJETIVOS: La efedrina es el vasopresor más utilizado en obstetricia y la etilefrina es muy usada en anestesia regional. El objetivo de este estudio fue el de comparar la efedrina con la etilefrina para la corrección de la hipotensión arterial materna durante raquianestesia para cesárea electiva. MÉTODO: Se estudiaron 120 embarazadas divididas aleatoriamente en dos

  6. Analysis of main influence factors on coronary artery image quality with 64-multidetector row helical CT using a pulsating cardiac phantom

    International Nuclear Information System (INIS)

    Objective: To explore the main influence factors (heart rate, rotation speed, and reconstruction algorithm) on the image quality of coronary artery with 40 mm VCT (64-detector row helical CT) using a pulsating cardiac phantom. Methods: An adjustable pulsating cardiac phantom (GE) containing predetermined simulated coronary arteries was scanned using a 40 mm VCT (GE LightSpeed CT) with cardiac pulsating rates of 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, and 115 beats per minute (bpm). The variable rotation speeds technique of 0.35 s, 0.40 s, and 0.45 s were used, respectively. The raw data were reconstructed using both one-sector and multi-sector reconstruction algorithm at optimal window of the R-R interval. The image quality score (IQS) was evaluated by two radiologists according to the same evaluation standard of reformated image. The correlation between heart rate (HR), roation speed, reconstruction algorithm, and IQS were analyzed. The IQS as independent variable and the HR, rotation speed, reconstruction algorithm as dependent variables were analyzed by multiple linear regression analysis. Results: The heart rate and the reconstruction algorithm had significant influence on IQS. The rotation speed (0.35s, 0.40 s, and 0.45 s) didn't have significant influence on IQS. There was linear regression relationship between heart rate, reconstruction algorithm and IQS (P<0.01). The equation of multiple regression was IQS=5.154-0.046 x (HR) + 0.500 x (reconstruction algorithm). The multi-sector reconstruction algorithm improved the image quality than one-sector did. Conclusion: The main influence factors on the image quality of coronary artery can be evaluated with 40 mm VCT using a pulsating cardiac phantom. It plays an important role in clinical research and application. (authors)

  7. EL PRINCIPIO DE VARIABILIDAD COMO FACTOR DETERMINANTE EN LA TÁCTICA INDIVIDUAL DEL SAQUE EN VOLEIBOL MASCULINO DE NIVEL INTERNACIONAL

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    A. Oña

    2010-09-01

    Full Text Available

     

    RESUMEN

    La investigación en el voleibol masculino de alto nivel en los últimos años otorga al saque una gran importancia en la evolución de este deporte. La técnica de saque empleada se revela como un factor decisivo, sin embargo no conocemos si el rendimiento de esta acción se mantiene de manera uniforme o varía conforme transcurre el encuentro. De este modo el objetivo del presente estudio es conocer la evolución del rendimiento en el transcurso de la competición, diferenciando las mediciones por sets.
    Se tomó como población objeto de estudio a los jugadores de los Juegos Olímpicos de Atlanta en 1996, último acontecimiento de la máxima relevancia en el voleibol internacional. Un total de doce equipos nacionales masculinos, confrontados en 42 encuentros, distribuidos en 149 sets. Para seleccionar la muestra se recurrió a 33 sets de la competición masculina, de entre 14 encuentros, de los que se registraron 2030 casos de cambio de saque.
    Se encontró que la variable set influye, de manera altamente significativa, en el rendimiento de recepción, lo que nos sugiere determinadas exigencias en el planteamiento estratégico del saque.
    PALABRAS CLAVE: voleibol, saque, recepción, alto rendimiento, variabilidad.

     

    ABSTRACT

    The research in male volleyball of high level in the last years grants to serve a great importance in the evolution of this sport. The technique of serving employee is revealed as a decisive factor, however we don’t know if the performance of this action stays in an uniform way or it varies as the encounter lapses. In this way the objective of the present study is to know the evolution of the performance in the course of the competition

  8. Factors associated to patients' noncompliance with hypertension treatment Factores asociados a la no adhesión de los pacientes al tratamiento de hipertensión arterial Fatores associados à não adesão dos pacientes ao tratamento de hipertensão arterial

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    Camila Dosse

    2009-04-01

    Full Text Available The greatest challenge posed by Systemic Hypertension (SH is related to patients' compliance with treatment. Thus, this study aimed to determine attendance of these patients to medical appointments and the percentage of adherence to medication and non-medication regimens, and also identify the main reasons hypertensive patients report for non-adherence. This is a descriptive study with 68 hypertensive patients (64.71% women with average age of 63.9 years at a teaching outpatient clinic. The instruments used for data collection were: multiprofesional team care report form, the Morisky-Green test and telephone interview. The results show that 61.76% attended the medical consultations, 86.76% did not comply with the medication regimen and 85.29% did not comply with the non-medication regimen, reporting at least one non-healthy life habit. The emotional factor was the most reported (69.12% among patients' reasons for non-adherence to treatment. The study can support interventions in care delivery to patients with systemic hypertension, with a view to improving their level of adherence and quality of life.El mayor desafío de la hipertensión arterial sistémica (HAS es la adhesión de los pacientes a su tratamiento, así, este estudio tuvo como objetivos determinar la frecuencia a las consultas y el porcentaje de adhesión al tratamiento medicamentoso y no medicamentoso, además de identificar los principales motivos referidos por los pacientes hipertensos para la no adhesión. Se trata de estudio descriptivo, realizado con 68 hipertensos en un ambulatorio escuela, con 64,71% de mujeres (promedio de edad de 63,9 años. Los instrumentos utilizados para recolección de datos fueron: formulario de atención del equipo multiprofesional, la prueba de Morisky-Green y la búsqueda a través del teléfono. Los resultados: muestran que 61,76% eran asiduos a las consultas, 86,76% no presentaron adhesión al tratamiento medicamentoso y 85,29% al tratamiento no

  9. Myocardial transfection of hypoxia inducible factor-1α via an adenoviral vector during coronary artery bypass grafting. A multicenter phase I and safety study

    International Nuclear Information System (INIS)

    Increasing numbers of patients with advanced coronary artery disease have limited options for percutaneous and/or surgical revascularization. A prospective, randomized, phase I clinical multicenter trial was performed to assess the feasibility and safety of delivering a pro-angiogenic transcription factor termed 'hypoxia inducible factor-1α', delivered to ischemic cardiac muscle via a type 2 adenoviral (Ad2HIF) vector. The 13 patients were included under the following criteria: 1 hypoperfused area of viable ventricular muscle without options for revascularization and left ventricular ejection fraction ≥30%. After coronary artery bypass grafting was completed, 10 injections of the study drug (n=10), in 3 escalating doses up to 1 x 1011 viral particles or saline (n=3) as a placebo control, were injected intramyocardially. After completion of the 1-year follow-up, all patients had uncomplicated postoperative courses, are alive and feeling well; 1 patient had a self-limited run of tachycardia postoperatively and at 6 months, 1 patient developed recurrent angina. Positron emission tomography perfusion analysis revealed improvement in the Ad2HIF injected areas in selected patients. These data support the feasibility and preliminary safety of adenoviral transfection with Ad2HIF in regions of viable myocardium. Additional studies will be required to determine the efficacy and safety of Ad2HIF. (author)

  10. Estudio de la utilidad del índice de cintura-cadera como predictor del riesgo de hipertensión arterial en niños y adolescentes

    OpenAIRE

    Emilio González-Jiménez; Miguel Ángel Montero-Alonso; Jacqueline Schmidt-Rio Valle

    2013-01-01

    Objetivos: Los objetivos de este estudio fueron verificar la existencia de una asociación significativa entre el estado nutricional de los alumnos y los valores del índice de cintura-cadera. En segundo lugar, comprobar una posible correlación entre los valores del índice de cintura-cadera y los niveles de presión arterial sistólica y diastólica. Muestra y metodología: Una población de 1001 adolescentes de entre 9 y 17 años de edad, pertenecientes a 18 centros educativos de las provincias de G...

  11. Sangrado transvaginal durante el embarazo, como factor de riesgo para isoinmunización al antígeno Rhesus-D Transvaginal bleeding during pregnancy associated with Rhesus-D isoimmunization

    OpenAIRE

    Edgar Hernández-Andrade; José Roberto Ahued-Ahued

    2003-01-01

    OBJETIVO: Evaluar el sangrado transvaginal en cualquier etapa del embarazo como factor de riesgo para la sensibilización al antígeno eritrocitario Rhesus-D en mujeres previamente no isoinmunizadas (Rh(-)NI), como una alternativa para la aplicación rutinaria de gama-globulina anti-D a la semana 28 de gestación. MATERIAL Y MÉTODOS: Estudio de casos y controles consecutivos, efectuado en el Instituto Nacional de Perinatología de la Ciudad de México, en el periodo de 1995 a 2001.Casos (n=24), pac...

  12. Triple spontaneous cervical artery dissection

    International Nuclear Information System (INIS)

    A 39-year-old healthy man had several transient ischaemic attacks suggesting left internal carotid artery (ICA) occlusion. There were no vascular risk factors and no preceding trauma. Colour-coded duplex sonography suggested a pseudo-occlusion of the left ICA, and cerebral angiography demonstrated dissection of the left ICA and both vertebral arteries. Angiography 6 months later was completely normal. This underlines the importance of four vessel angiography in young patients with dissections of cervical arteries. (orig.)

  13. Carotid artery calcification at the initiation of hemodialysis is a risk factor for cardiovascular events in patients with end-stage renal disease: a cohort study

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    Ikeda Hirofumi

    2011-10-01

    Full Text Available Abstract Background Vascular calcification has been recognized as a risk factor for cardiovascular (CV events in patients with end-stage renal disease (ESRD. However, the association of carotid artery calcification (CAAC with CV events remains unknown. The aim of this study was to elucidate whether CAAC is associated with composite CV events in ESRD patients. Methods One-hundred thirty-three patients who had been started on hemodialysis between 2004 and 2008 were included in this retrospective cohort study. These patients received multi-detector computed tomography to assess CAAC at the initiation of hemodialysis. Composite CV events, including ischemic heart disease, heart failure, cerebrovascular diseases, and CV deaths after the initiation of hemodialysis, were examined in each patient. Results CAAC was found in 94 patients (71%. At the end of follow-up, composite CV events were seen in 47 patients: ischemic heart disease in 20, heart failure in 8, cerebrovascular disease in 12, and CV deaths in 7. The incidence of CAAC was 87% in patients with CV events, which was significantly higher than the rate (62% in those without. Kaplan-Meier analysis showed a significant increase in composite CV events in patients with CAAC compared with those without CAAC (p = 0.001, log-rank test. Univariate analysis using a Cox hazards model showed that age, smoking, common carotid artery intima-media thickness and CAAC were risk factors for composite CV events. In multivariate analysis, only CAAC was a significant risk factor for composite CV events (hazard ratio, 2.85; 95% confidence interval, 1.18-8.00; p = 0.02. Conclusions CAAC is an independent risk factor for CV events in ESRD patients. The assessment of CAAC at the initiation of hemodialysis is useful for predicting the prognosis.

  14. Efficacy of optimal long-term management of multiple cardiovascular risk factors (CVD) on walking and quality of life in patients with peripheral artery disease (PAD): Protocol for randomized controlled trial

    OpenAIRE

    Oka, Roberta K; Conte, Michael S; Owens, Christopher D; Rapp, Joseph; Fung, Gordon; Alley, Hugh F.; Giacomini, John C; Myers, Jonathan; Mohler, Emile R.

    2012-01-01

    Peripheral artery disease (PAD) is an understudied chronic illness most prevalent in elderly individuals. PAD patients experience substantial walking impairment due to symptoms of limb ischemia that significantly diminishes quality of life (QOL). Cardiovascular disease (CVD) morbidity and mortality is increased in this population because of aggressive atherosclerosis resulting from untreated CVD risk factors. Despite current national guidelines recommending intensive CVD risk factor managemen...

  15. What does my patient's coronary artery calcium score mean? Combining information from the coronary artery calcium score with information from conventional risk factors to estimate coronary heart disease risk

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    Pletcher Mark J

    2004-08-01

    Full Text Available Abstract Background The coronary artery calcium (CAC score is an independent predictor of coronary heart disease. We sought to combine information from the CAC score with information from conventional cardiac risk factors to produce post-test risk estimates, and to determine whether the score may add clinically useful information. Methods We measured the independent cross-sectional associations between conventional cardiac risk factors and the CAC score among asymptomatic persons referred for non-contrast electron beam computed tomography. Using the resulting multivariable models and published CAC score-specific relative risk estimates, we estimated post-test coronary heart disease risk in a number of different scenarios. Results Among 9341 asymptomatic study participants (age 35–88 years, 40% female, we found that conventional coronary heart disease risk factors including age, male sex, self-reported hypertension, diabetes and high cholesterol were independent predictors of the CAC score, and we used the resulting multivariable models for predicting post-test risk in a variety of scenarios. Our models predicted, for example, that a 60-year-old non-smoking non-diabetic women with hypertension and high cholesterol would have a 47% chance of having a CAC score of zero, reducing her 10-year risk estimate from 15% (per Framingham to 6–9%; if her score were over 100, however (a 17% chance, her risk estimate would be markedly higher (25–51% in 10 years. In low risk scenarios, the CAC score is very likely to be zero or low, and unlikely to change management. Conclusion Combining information from the CAC score with information from conventional risk factors can change assessment of coronary heart disease risk to an extent that may be clinically important, especially when the pre-test 10-year risk estimate is intermediate. The attached spreadsheet makes these calculations easy.

  16. Aterosclerosis, colesterol y pared arterial: algunas reflexiones

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    José E Fernández-Britto Rodríguez

    1999-12-01

    Full Text Available Los estudios que vinculan al colesterol con el desarrollo de la aterosclerosis, datan de la década de los años 50, los factores de riesgo cardiovascular como la hipertensión arterial, la diabetes mellitus, el tabaquismo y la obesidad entre otros, han mostrado tener una fuerte asociación con el colesterol. En el presente artículo se aborda los elementos básicos actuales de la fisiopatología de la aterosclerosis relacionados con el colesterol y la pared arterial, se incluyó la fisiopatología de las lipoproteínas de baja densidad asociadas con el colesterol (LDL-c, los factores que influyen en su concentración entre los fluidos de la íntima y los extravasculares, el papel de las LDL-c modificadas en la íntima vascular, la contribución de la Lp(a al desarrollo de la aterosclerosis, así como la participación de lipoproteínas de alta densidad asociados con el colesterol (HDL-c y su transporte reverso como mecanismo que se opone al proceso aterosclerótico.The studies linking cholesterol to the development of atherosclerosis date back to the 1950s. The cardiovascular risk factors such as hypertension, diabetes mellitus, smoking and obesity, among others, have proved to have a strong association with cholesterol. In this paper the present basic elements of the physiopathology of atherosclerosis related to cholesterol and to the arterial wall are approached. The physiopathology of the low density lipoproteins cholesterol (LDL-c, the factors influencing on its concentration among the fluids of the intima and the extravascular fluids, the role of the modified LDL-c in the vascular intima, the contribution of Lp(a to the development of atherosclerosis, as well as the participation of high density lipoproteins quit on cholesterol (HDL-c and its reverse transport as a mechanism opposing to the atherosclerotic process are also included.

  17. Espessamento médio-intimal na origem da artéria subclávia direita como marcador precoce de risco cardiovascular Intima-media thickness in the origin of right subclavian artery as an early marker of cardiovascular risk

    OpenAIRE

    Carlos Alberto Engelhorn; Ana Luiza Engelhorn; Maria Fernanda Cassou; Cassiana Casagrande Zanoni; Carlos José Gosalan; Emerson Ribas; Adriana Pacholok; Marcela de Fátima Koehler

    2006-01-01

    OBJETIVO: O espessamento médio-intimal (EMI) na artéria carótida comum é considerado fator de risco cardiovascular e marcador de doença arterial coronariana precoce. O objetivo deste trabalho foi investigar a existência de correlação entre o EMI nas artérias carótidas e na origem da artéria subclávia direita, e avaliar o EMI na artéria subclávia como um marcador mais precoce para avaliação de risco cardiovascular. MÉTODOS: Cento e seis pacientes consecutivos, 52 homens e 54 mulheres, com médi...

  18. Evaluación y diseño de bacterias lácticas (BAL) de origen alimentario y de otros hospedadores como factorías celulares de producción de bacteriocinas

    OpenAIRE

    Jiménez Martínez, Juan José

    2015-01-01

    Las bacterias lácticas BAL constituyen un grupo microbiano muy interesante por sus características biotecnológicas asociadas a la producción de péptidos antimicrobianos, otros péptidos bioactivos, enzimas de utilización industrial y utilización como probióticos o por su posible utilización como factorías celulares de producción de proteínas, péptidos, enzimas y otros metabolitos de interés en la industria alimentaria o como terapeúticos en medicina humana y veterinaria y en producción animal....

  19. Cesárea prévia como fator de risco para o descolamento prematuro da placenta Previous cesarean section as a risk factor for abruptio placentae

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    Fábio Roberto Cabar

    2004-10-01

    Full Text Available OBJETIVO: investigar a relação entre o antecedente de cesárea e a ocorrência do descolamento prematuro da placenta (DPP. MÉTODOS: estudo retrospectivo em que foram avaliados os dados referentes a 6495 partos realizados no período entre abril de 2001 e janeiro de 2004. Foram adotados como critérios de inclusão: diagnóstico de DPP confirmado por exame da placenta após o parto, gestação única, peso do recém-nascido superior a 500 g e idade gestacional acima de 22 semanas e ausência de história de trauma abdominal na gestação atual. Para cada caso de DPP incluído no estudo foram selecionados cinco controles, obedecendo ao seguinte pareamento: paridade, idade gestacional (30 semanas, diagnóstico materno de síndrome hipertensiva na gestação índice, antecedente de cicatriz uterina prévia não relacionada à operação cesariana, diagnóstico de rotura prematura de membranas ou diagnóstico de polidrâmnio. A análise univariada das variáveis contínuas foi realizada utilizando-se o teste t de Student e as variáveis categóricas foram avaliadas por meio de teste exato de Fisher ou teste de chi2, com níveis descritivos (p menores que 0,05 considerados significantes. RESULTADOS: 34 casos de pacientes com diagnóstico de DPP preencheram os critérios de inclusão (incidência de 0,52%. Para o grupo controle foram selecionadas 170 pacientes que obedeceram aos critérios de pareamento propostos. No grupo de pacientes com DPP, 26,5% apresentavam antecedente de parto cesárea (9 casos, ao passo que, no grupo controle, esse antecedente foi observado em 21,2% das pacientes (36 casos. Não houve diferença estatisticamente significativa na incidência de cesárea prévia entre os dois grupos estudados (p=0,65, OR=1,34, IC 95%=0,53-3,34. CONCLUSÃO: o aspecto abordado neste estudo, isto é, a associação do DPP em pacientes com cicatriz uterina de cesárea, não pôde ser confirmado com a presente casuística.PURPOSE: to study the

  20. Dual anterior descending coronary artery associated with coronary artery disease

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    Siqueira Luciane da L. V.

    2003-01-01

    Full Text Available The patient is a male with risk factors for coronary artery disease, who was referred for cardiac catheterization after acute myocardial infarction in the inferior wall. The patient underwent transluminal coronary angioplasty in the right coronary artery with successful stent implantation.

  1. Factores psicosociales laborales relacionados con la tensión arterial y síntomas cardiovasculares en personal de enfermería en México Psychosocial work factors associated to blood pressure and cardiovascular symptoms among Mexican nurses

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    Arturo Juárez-García

    2007-04-01

    Full Text Available OBJETIVO: Determinar si la tensión laboral según el modelo de Karasek y la inseguridad en el empleo se asocian significativamente con indicadores cardiovasculares, tales como la tensión arterial (TA y los síntomas cardiovasculares (SC, considerando factores tradicionales de riesgo cardiovascular (edad, índice de masa corporal, consumo de tabaco y alcohol, entre otros. MATERIAL Y MÉTODOS: En una muestra de 109 enfermeras de un hospital del sector público de la Ciudad de México durante el mes de julio del 2004, se aplicó el Cuestionario del Contenido de Trabajo (JCQ, otro de Síntomas Cardiovasculares y se utilizó un monitor digital para medir la TA mediante un protocolo de puntos estimados en el puesto de trabajo. RESULTADOS: Existe una relación estadísticamente significativa entre tales variables (beta entre .20 y .24, aun considerando factores tradicionales de riesgo cardiovascular. CONCLUSIONES: La relación entre TA y el modelo de tensión laboral es válida en población mexicana y destaca la asociación de la inseguridad en el empleo con indicadores cardiovasculares, lo que hace trascendente su importancia en el contexto laboral mexicano. Se sugieren futuros estudios y un trabajo de prevención y vigilancia permanente de estos factores en los campos de la salud ocupacional, así como en la salud pública en términos de su rol en la epidemiología cardiovascular.OBJECTIVE: To determine if job stress, according with Karasek's model, and job insecurity are significantly associated with cardiovascular indicators such as blood pressure (BP and cardiovascular symptoms (CS, considering traditional risk factors for cardiovascular disease (age, body mass index, smoking, alcohol consumption, among others. MATERIAL AND METHODS: A job content questionnaire (JCQ and one for cardiovascular symptoms were administered to a sample of 109 nurses from a public hospital in Mexico City during July 2004. A digital monitor was utilized to measure BP

  2. SUICIDIO: EL GÉNERO COMO FACTOR DE RIESGO VIOLENCIA AUTOINFLINGIDA: CASO DE MEXICALI, BAJA CALIFORNIA. FRONTERA NORTE DE MÉXICO

    OpenAIRE

    Elsa de J. Hernández Fuentes; David F. Fuentes Romero; Irma A. González Hernández; Elsa del Carmen Villegas Morán

    2012-01-01

    El presente artículo tiene como objetivo caracterizar la mortalidad debido a suicidios y su comportamiento por género en la ciudad de Mexicali, Baja California, México, Municipio de Mexicali. Este estudio parte de la consideración de la dinámica social como la relación e interacción de las variables exógenas o variables autónomas, es decir aquellas que no se explican a través de un modelo económico determinado, por lo cual el suicidio será visto como un fenómeno social, producto de la dinámic...

  3. Sappan Lignum Extract Inhibits Restenosis in the Injured Artery through the Deactivation of Nuclear Factor-κB

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    Guang Long

    2014-08-01

    Full Text Available The aim of the study was to explore whether Sappan Lignum Extract (SLE would inhibit vascular restenosis in injured artery and its inhibitory mechanism by using a balloon-injured rat carotid artery restenosis model. Different doses of SLE were administered to the rats by tube feeding, starting from four days before surgery and continuing twice per day for two weeks after carotid injury. Injured carotid arteries isolated from rats were embedded in paraffin block and tissue sections were stained with H&E to assess restenosis. The Effects of SLE on vascular restenosis, which are involved in smooth muscle cell cycle, NF-κB p65 expression, and Superoxide (O2- production, was assessed by RT-PCR, western blot assay, and immunohistochemistry. The results showed that in a rat carotid model of balloon dilatation injury, SLE significantly reduced the intimal-to-medial area ratio and vascular restenosis after 14 days of the injury. Immunohistochemistry study revealed no inhibited PCNA expression caused by SLE. Rat serum containing Sappan Lignum (RSC was found neither anti-proliferative effect in cultured vascular smooth muscle cells (VSMCs and nor arrest cell cycle progress detected by flow cytometry. RSC remarkably decreased the expression of TNF-α mRNA and protein in cultured VSMCs. Electrophoretic mobility shift assay proved that RSC inhibited the binding of NF-κB to specific DNA sequences in TNF-α treated VSMCs. Western blot pronounced that RSC and N-acetyl-L-cysteine (NAC reduced expression of NF-κB p65 in nuclear extracts in TNF-α treated VSMCs. RSC and NAC also attenuated superoxide anion generation in TNF-α treated VSMCs. In summary, the inhibitory effects of SLE on vascular restenosis may not be mediated through inhibiting vascular cell proliferation, but through inhibiting vascular inflammation instead, which may be attributed to the inhibition of TNF-α and subsequent deactivation of NF-κB, which was in part mediated through inhibiting

  4. Factores de riesgo asociados con la prevalencia de hipertensión arterial en adultos de Bucaramanga, Colombia

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    Bautista Leonelo E

    2002-01-01

    Full Text Available Objetivo. Cuantificar la prevalencia de hipertensión arterial y su asociación con edad, sexo, estrato socioeconómico e índice de masa corporal. Material y métodos. Encuesta transversal, de base poblacional, hecha en 1996, en una muestra aleatoria de 356 adultos superscript three 20 años de edad, residentes en Bucaramanga, Colombia, en quienes se midieron peso, talla y presión arterial y se consideraron edad y sexo. Se usaron regresión lineal robusta y regresión binomial para estimar el efecto independiente de distintas variables sobre presión sistólica (PS, presión diastólica (PD e hipertensión arterial (HTA. Resultados. Las medias de PS y PD fueron significativamente mayores en hombres (122.5 y 88.1 mmHg que en mujeres (117.2 y 75.4 mmHg. La PS ajustada aumentó con la edad, mas en hombres que en mujeres, la PD no cambió significativamente con la edad. Por cada aumento de un kg/m² la PS y la PD aumentaron 0.76 y 0.69 mmHg, respectivamente. Participantes de estrato socioeconómico bajo tuvieron una PS 6.8 y una PD 9.8 mmHg mayor que los del nivel alto. La prevalencia ajustada de HTA (PHTA aumentó con la edad siendo mayor en los superscript three50 años que en los de 20 a 30. El sexo no tuvo efecto sobre la PHTA (p=0.795. Por cada aumento de un kg/m² la PHTA aumentó 3% y las personas del estrato socioeconómico bajo tuvieron una PHTA 1.84 veces mayor que las del alto. Conclusiones. La PHTA fue alta. Existe gran potencial para la prevención controlando el sobrepeso y la obesidad. Es necesario corroborar con nuevos estudios el aumento de la prevalencia en el estrato socioeconómico bajo e identificar sus causas.

  5. El factor de transferencia como inductor de la expresión de RNAm de IFN-γ e IL-2 en pollos vacunados contra influenza aviar

    Directory of Open Access Journals (Sweden)

    A Bravo-Blas

    2010-01-01

    Full Text Available La influenza aviar es una enfermedad de gran importancia económica para la industria avícola. En México sólo se ha reportado la cepa H5N2 de baja patogenicidad y ésta se controla mediante la vacunación con virus inactivado. Esta vacuna en emulsión reduce la presencia de signos, pero no la eliminación viral. Desde hace más de 50 años se ha informado acerca de la eficacia del Factor de Transferencia (FT como inmunomodulador en casos clínicos humanos y en menor cantidad en modelos animales. El objetivo de este trabajo fue el de establecer la dosis que produce un mayor porcentaje de expresión del RNAm de dos citocinas: IL-2 y de IFN-γ. Se diseñó un experimento para evidenciar la expresión del RNAm de estas dos citocinas en pollos previamente inoculados con FT específico para influenza aviar. En la primera fase se aplicaron 0,1, 1, y 10 unidades de FT a diferentes grupos de pollos, posteriormente se realizó la PCR a partir de tejido esplénico. En la segunda fase se aplicó el FT junto con la vacuna a tres nuevos grupos de pollos. Del experimento 1 solamente IL-2 tuvo un porcentaje mayor de positivos (58,33% con 1 unidad (P < 0,05. En cambio, en el experimento 2, con 1 unidad se obtuvo 75% de positivos para IL-2 (P < 0,05 y 100% para IFN-γ (P < 0,01. De estos resultados su puede concluir que al aplicar una unidad de FT (equivalente a 7,3 μg de proteína al inicio del experimento y 10 días después otra unidad de FT junto con la vacuna inactivada de IA se indujo la expresión del RNAm de IFN-γ e IL-2.

  6. Número ideal de filhos como fator de risco para laqueadura tubária Ideal number of children as a risk factor for tubal ligation

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Campos de Carvalho

    2004-12-01

    Full Text Available O objetivo deste artigo é avaliar a associação entre o número ideal de filhos (NIF e a realização da laqueadura. Foi feito um estudo de caso-controle aninhado, com base em uma análise secundária de dados obtidos em um estudo de coorte sobre a saúde reprodutiva de mulheres em Campinas, São Paulo, Brasil, que teve como sujeitos 3.878 mulheres, das quais 1.012 eram laqueadas (casos. A relação entre NIF e o número de nascidos vivos (NV foi dividida em duas categorias (NIF > NV e NIF ¾ NV. Foram calculados os riscos relativos estimados (odds ratio para a realização de laqueadura e seus respectivos intervalos de confiança (IC 95% para a relação NIF/NV, estratificando-se para outras dez variáveis. Todas as variáveis preditoras foram incluídas em um modelo de regressão logística para identificar os fatores independentemente associados à esterilização definitiva. Observou-se que o risco de laqueadura foi maior entre as mulheres com NIF The purpose of this paper was to evaluate the association between ideal number of children (INC and female sterilization. A nested case-control study was performed through a secondary analysis of data from a cohort study on the reproductive health of women in Campinas, São Paulo, Brazil. A total of 3,878 women were included, 1,012 being sterilized (cases. The relationship between INC and number of live births (LB was divided in two categories (INC > LB and INC ¾ LB. The relative risks of performing tubal ligation were calculated (odds ratio with their respective 95% confidence intervals for the relation INC/LB and all control variables. All predictor variables were included in a logistic regression model in order to identify the factors independently associated with female sterilization. The results showed that the risks of tubal ligation were higher among women with INC < LB, higher age, with partners, higher family income, more than two previous pregnancies, more deliveries, fewer abortions

  7. ESTRATEGIA DEL RENDIMENTO DE LA CALDAD COMO FACTOR COMPETITIVO EN EDUCACIÓN A DISTANCIA Y EDUCACIÓN SUPERIOR EN EDUCCIÓN UNIVERSITARIA

    OpenAIRE

    María Candelaria Rodríguez Pérez; María Morfin Otero; Víctor Manuel González Romero,; Claudio Rafael Vásquez Martínez; Angélica Contreras Cueva

    2009-01-01

    Se ve, a lo largo de la evaluación como algunos criterios de rendimiento académico, considerados como los más avanzados en el proceso de aprendizaje, indicadores por lo mismo de mayor cualificación, presentan logros inferiores por parte de los estudiantes de EDI (Educación a Distancia). Esto no es gratuito y tiene origen en la orientación pedagógica de la educación primaria y secundaria preocupada más por informar y desarrollar destrezas elementales, que por generar en sus alumnos capacidades...

  8. El Soporte Conductual Positivo y la comunicación como factores clave en la intervención educativa de los niños con TEA

    OpenAIRE

    Lizondo-Nieto, Elina Marcela

    2013-01-01

    En este trabajo, vamos a estudiar el Soporte Conductual Positivo aplicado a la Escuela (SCPE) como un método de intervención educativa que permite construir el aprendizaje de los niños con trastornos del espectro autista (TEA) a partir de las conductas problemáticas que estos manifiestan convirtiéndolas en habilidades, que, a su vez, van a ser reforzadas a través del sistema TEACCH, lo que combinado con un sistema alternativo y aumentativo de comunicación (SAAC), como el PECS, va ...

  9. High prevalence of risk factors in coronary artery disease in EUROPA gives HOPE for ACE inhibitors after PEACE

    DEFF Research Database (Denmark)

    Pedersen, S.A.; Galatius, S.; Olsen, M.H.;

    2008-01-01

    Background: Routine use of ACE inhibitors (ACE-I) as secondary preventive therapy for all patients with coronary artery disease (CAD) is challenged by the PEACE trial. Currently it is unclear to what extent ACE-I should be used in CAD populations. Purpose: To analyze the prevalence of left...... ventricular systolic dysfunction, diabetes, myocardial infarction and hypertension in an unselected and consecutive population of patients with documented CAD and evaluate the potential need for ACE-I treatment in a real-life scenario. Methods: We searched a database containing all invasive cardiac...... investigations in three hospitals in Copenhagen from July 1, 2000 to June 30, 2003. Patients with no angiographic sign of CAD were excluded. Results: Among 7,345 patients, 4,180 had stable CAD and 3,165 had acute coronary syndrome (ACS). Among the stable CAD patients 78% had at least one of the following...

  10. Presión arterial en adolescentes mexicanos: clasificación, factores de riesgo e importancia

    OpenAIRE

    Salcedo-Rocha, Ana L.; García de Alba, Javier E.; Margarita Contreras-Marmolejo, Margarita

    2012-01-01

    Objetivo Determinar características de riesgo y  frecuencia  de niveles de presión sanguínea de acuerdo a dos criterios clasificatorios: 7º Comité Nacional Conjunto (JNC-7)  y 4º Reporte del grupo de trabajo para el diagnostico, evaluación y tratamiento de la hipertensión arterial en niños y adolescentes. En un grupo de escolares de 12 a 16 años de la ciudad de León,  México. Métodos Estudio observacional, descriptivo, transversal de  458 adolescentes varones. Previo consentimiento informado ...

  11. Variations in the Prevalence of Risk Factors for Coronary Artery Disease in Rio Grande do Sul-Brazil: A Comparative Analysis between 2002 and 2014

    Directory of Open Access Journals (Sweden)

    Iseu Gus

    2015-01-01

    Full Text Available AbstractBackground:Due to the importance of coronary artery disease (CAD, continuous investigation of the risk factors (RFs is needed.Objective:To evaluate the prevalence of RFs for CAD in cities in Rio Grande do Sul State, and compare it with that reported in a similar study conducted in the same cities in 2002.Methods:Cross-sectional study on 1,056 healthy adults, investigating the prevalence and absolute and relative frequencies of the following RFs for CAD: obesity, systemic arterial hypertension (SAH, dyslipidemias, smoking, sedentary lifestyle, diabetes mellitus, and family history, as well as age and sex. Data was collected in 19 cities, host of the Offices of the Regional Coordinators of Health, as in the 2002 study.Results:Twenty-six percent of the sample consisted of older adults and 57% were women. The prevalence of sedentary lifestyle was 44%, history family 50%, smoking 23%, overweight/obesity 68%, dyslipidemia (high cholesterol levels 43%, SAH 40%, and diabetes 11%. When compared to the 2002 study, the prevalence of active smoking and sedentary behavior decreased, whereas the prevalence of hypertension, dyslipidemia and obesity increased. Obesity is the most prevalent RF in women, and SAH the most prevalent in men.Conclusions:The prevalence of RFs for CAD in Rio Grande do Sul State remains high. Hypertension, obesity and dyslipidemia are still prevalent and require major prevention programs. Smoking and physical inactivity have decreased in the state, suggesting the efficacy of related campaigns.

  12. Superficial temporal artery calcification in patients with end-stage renal disease: Association with vascular risk factors and ischemic cerebrovascular disease

    Directory of Open Access Journals (Sweden)

    Zeeshan Anwar

    2011-01-01

    Full Text Available Background and Purpose: Extracranial superficial temporal artery (STA calcification is an unusual finding seen in patients with chronic kidney disease and has unknown ramifications with respect to intracranial ischemic disease. We sought to determine the association between the risk factors for vascular calcification and this rare phenomenon, in patients with chronic renal failure, and to assess the coexistence of cerebral ischemia. Materials and Methods: Medical records and laboratory data on risk factors for vascular calcification were retrospectively retrieved for 453 patients with a discharge diagnosis of end-stage renal disease (ESRD. CT head examinations were reviewed to identify and associate STA calcification with 1 risk factors for the vascular calcification, 2 intracranial artery calcification, and 3 cerebral ischemia (white matter and/or cortical ischemic changes. Results: STA calcification was present in 9.9% (45/453 of the studied cohort. The prevalence of cerebral ischemia was 24.4% (11/45 in patients with STA calcification and 9.3% (38/408 in patients without it. Diabetes mellitus (OR: 2.56, 95% CI: 1.059-6.208; P=0.037 was independently associated with the risk of STA calcification. The risk of cerebral ischemia, however, was not related to STA calcification (P=0.221. Conclusion: The presence of diabetes mellitus is important in describing the risk of STA calcification in patients with ESRD, whereas age, gender, hypertension, serum calcium, serum phosphate, or serum hemoglobin levels are not. The risk of cerebral ischemia is not related to STA calcification but has the strongest association with diabetes mellitus.

  13. True aneurysm of brachial artery.

    Science.gov (United States)

    Hudorović, Narcis; Lovričević, Ivo; Franjić, Dario Bjorn; Brkić, Petar; Tomas, Davor

    2010-10-01

    True upper extremity peripheral artery aneurysms are a rarely encountered arterial disorder. Following computer-tomography angiographic (CT-a) imaging examination, true saccular aneurysm, originating from the left brachial artery was diagnosed in the 77-year-old female without history of trauma. The aneurysm was resected by surgical intervention, and primary repair of the brachial artery was performed by interposition of a part of great saphenous vein harvested from the left groin and creation of two end-to-end anastomoses between interposition graft and previously resected part of brachial artery. No complication was observed during the follow-up. Surgical intervention for upper extremity aneurysms should be initiated without delay. Factors combined with minimal morbidity associated with repair suggest that surgical repair should be performed routinely for true upper extremity arterial aneurysms. PMID:20865459

  14. Información y consumo de drogas. La TV como factor de riesgo en niños escolares Information Sources and Drugs Consumption. TV: a Risk Factor in Schoolchildren

    Directory of Open Access Journals (Sweden)

    Carin Alexa Prieto Cruz

    2009-10-01

    Full Text Available El uso indebido de drogas en la población en general es un área en continuo estudio que requiere de un mayor conocimiento de las variables asociadas para lograr una mejora en los programas de prevención y la información se presenta como una de las de menor estudio; el objetivo principal de la presente investigación fue determinar variables predictoras de consumo de drogas en un grupo de escolares a partir de la información que tengan de ellas. El tipo de estudio fue transversal; el modelo de regresión logística multifactorial determinó las variables asociadas al consumo de drogas en una muestra de 570 niños; se concluyó que el factor que más afectó al objeto de estudio fue la fuente de información, definida por la televisión, de la cual se piensa que la presentación de consumidores de drogas en ella es significativamente negativa y se toma de una forma simplista. Drug consumption in the population represents an area of continuous study which requires substantial knowledge of the associated variables in order to improve programs dedicated to consumption prevention. The main goal of this research was to determine the variables which can predict drug consumption in a group of 570 schoolchildren based on the knowledge the target group has got about these drugs. The type of study was transversal. The multifactorial logistic regression model determined factors associated with drug consumption in the sample. The most important factor contributing to consumption was television. The presentation of drug consumers on television is thought to be significantly negative and it is taken in a simplistic form.

  15. Intra-arterial thrombolysis in basilar artery occlusions combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitors in basilar artery thrombosis

    Directory of Open Access Journals (Sweden)

    Gaikwad S

    2009-01-01

    Full Text Available Basilar artery thrombosis has high morbidity and mortality. Though intra-arterial thrombolytics have proven efficacy in the treatment of acute basilar artery occlusion, the elevation of procoagulant factors in the blood after intra-arterial thrombolysis could result in subsequent thrombus formation and clinical deterioration. Glycoprotein IIb/IIIa inhibitors have been shown to reduce this elevation in procoagulants. We present a pilot study of three cases of acute basilar artery occlusion treated with a combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitor with remarkable clinical recovery seen in all the patients.

  16. Growth hormone and insulin-like growth factor-1 in prognosis coronary artery disease in patients with obesity

    Directory of Open Access Journals (Sweden)

    Olga Viktorovna Shpagina

    2014-10-01

    Full Text Available Introduction. In patients with obesity coronary atherosclerosis and chronic heart failure (CHF progress rapidly and have a worse long-term prognosis than those with normal weight.Objective: To investigate the prognostic significance of GH and IGF-1 in the evaluation of cardiovascular risk in patients with obesity.Materials and Methods. The study included 75 men (mean age 55.31±6.32 years, which are overweight or have mild obesity (body mass index (BMI 28.69±3.6 kg/m2. Group 1 included 45 patients (age 56.4±6.29 years, BMI 28.69±3.69 kg/m2, blood pressure 124±10.18/80±4.59 mm Hg who underwent coronary angiography. Group 2 included 30 patients (mean age 53.6 ± 6.1 years, BMI 28.68±3.52 kg/m2, blood pressure 128±9/83±6.81 mm Hg, CAD who are excluded by treadmill test. The coronary artery calcium score was assessed in group 2. All participants were evaluated impaired glucose tolerance (IGT, triglycerides (TG, IGF-1 and GH, LPHD, LPLD, geometry of the heart chambers was assessed by echocardiography.Results. Patients in both groups did not differ in age, BMI, blood pressure. IGF-1 levels were not significantly different among the study groups. High circulating IGF-1 levels were frequently observed in group 1 (р=0.018. A statistically significant association of high IGF-1 observed with obesity (p=0.033, smoking (p=0.049, hypertension (p=0.002, end-diastolic dimension (p=0.045. GH was lower in group 1 compared with group 2 (p=0.046. Serum levels of GH are positively associated with EF (p=0.023 and E/A (p=0.043 and negatively associated with left atrial wall thickness (p=0.025 and coronary artery calcium score (p=0.005.Conclusion: 1. IGF-1 may be a useful indicator to assess the prognosis of CAD and CHF in patients with obesity. 2. Relative GH deficiency was more often associated with severe CAD in patients with obesity.

  17. ESTRATEGIA DEL RENDIMENTO DE LA CALDAD COMO FACTOR COMPETITIVO EN EDUCACIÓN A DISTANCIA Y EDUCACIÓN SUPERIOR EN EDUCCIÓN UNIVERSITARIA

    Directory of Open Access Journals (Sweden)

    María Candelaria Rodríguez Pérez

    2009-07-01

    Full Text Available Se ve, a lo largo de la evaluación como algunos criterios de rendimiento académico, considerados como los más avanzados en el proceso de aprendizaje, indicadores por lo mismo de mayor cualificación, presentan logros inferiores por parte de los estudiantes de EDI (Educación a Distancia. Esto no es gratuito y tiene origen en la orientación pedagógica de la educación primaria y secundaria preocupada más por informar y desarrollar destrezas elementales, que por generar en sus alumnos capacidades de observación, análisis, síntesis y desarrollo del pensamiento divergente, de conciencia social y de capacidad de liderazgo para orientar el proceso de cambio social.

  18. Las familias interculturales como ejemplo de nuevas formas familiares en un mundo globalizado: análisis de algunos factores de riesgo y de protección

    OpenAIRE

    Moscato, Gianluigi; Martos, María Jesús

    2016-01-01

    Como consecuencia de la consolidación del proceso migratorio, se han ido configurando, paulatinamente, nuevos núcleos familiares: las familias interculturales o mixtas, compuestas por un miembro autóctono y otro extranjero. Las familias interculturales representan un importante laboratorio para comprender las dinámicas sociales y emocionales que caracterizan una sociedad multicultural. Pero también, muy a menudo tienen que enfrentarse a situaciones de discriminación, falta de apoyo soc...

  19. Calidad de leche y queso como factor principal de las estrategias de desarrollo de productos lácteos de rumiantes menores

    OpenAIRE

    Mantecón, Ángel R

    2000-01-01

    Desde hace varios años la Estación Agrícola Experimental, Instituto del consejo superior de Investigaciones Científicas en León (España) ha venido colaborando con la Facultad de Ciencias Veterinarias de la Universidad del Centro de la Provincia de Buenos Aires (UNCPBA) en Tandil (Argentina), para el desarrollo de la actividad lechera ovina como alternativa a los sistemas ganaderos tradicionales en el país....

  20. Estudio de la autopercepción y los estilos de aprendizaje como factores asociados al rendimiento académico en estudiantes universitarios

    OpenAIRE

    Juan Miguel Bolívar López; Freddy Rojas Velásquez

    2014-01-01

    Los estudiantes que inician estudios universitarios, se sumergen en una nueva etapa académica totalmente desconocida. Las variables tradicionales que conforman sus estudios anteriores irrumpen de manera diferente. Por un lado, cambia la forma como adquirían sus conocimientos, las exigencias son mayores y el contenido es más denso, de ahí la necesidad de ajustar o incorporar nuevas estrategias de aprendizaje. Por el otro, por tratarse de adolescente enfrentados a un cambio educativo sustancia...

  1. Association between type 2 diabetes mellitus, biochemical factors and UCSNP-43 polymorphisms of CALPIN-10 gene in patients with atherosclerosis of coronary artery disease in Southern Iran population

    Science.gov (United States)

    Senemar, Sara; Edraki, Mohammad Reza; Toosi, Samane

    2016-01-01

    Introduction: Genetic variations in the calpain 10 gene (CALPIN-10), single nucleotide polymorphisms-43 (SNP-43), have increased the risk of type 2 diabete mellitus (T2DM) and coronary artery disease (CAD). Methods: We studied the control and CAD groups for association of association of SNP-43 in the CALPIN-10 gene with T2DM and other risk factors of its complications. Overall, we examined 452 individuals, 224 patients with CAD and 228 healthy subjects for CAD in Iranian population. All the subjects were genotyped for the CALPIN-10, SNP-43 by polymorphism chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods, using biochemical methods to detect fasting glucose and other biochemical factors in the blood sample. We assessed frequencies of SNP-43 alleles between CAD and normal population groups. Results: In CAD patients, the GG allele was significantly associated with T2DM and GG allele was causing high level of glucose. But in control group, there was no relationship between them. Between clinical and biochemical risk factors with different genotypes there was no significant difference in the compared group. Conclusion: The results of our study suggest no significant association between SNP-43 and the risk of T2DM. In other words, CALPIN-10 did not show a major diabetes gene pool capacity in normal southern Iranian population. PMID:27069562

  2. Coronary Microvascular Function and Cardiovascular Risk Factors in Women With Angina Pectoris and No Obstructive Coronary Artery Disease

    DEFF Research Database (Denmark)

    Mygind, Naja Dam; Michelsen, Marie Mide; Pena, Adam;

    2016-01-01

    microvascular dysfunction and the association with symptoms, cardiovascular risk factors, psychosocial factors, and results from diagnostic stress testing. METHODS AND RESULTS: After screening 3568 women, 963 women with angina-like chest pain and a diagnostic coronary angiogram without significant coronary....... CONCLUSION: Impaired CFVR was detected in a substantial proportion, which suggests that coronary microvascular dysfunction plays a role in the development of angina pectoris. CFVR was associated with few cardiovascular risk factors, suggesting that CFVR is an independent parameter in the risk evaluation of...

  3. The journal impact factor as a parameter for the evaluation of researchers and research El factor de impacto de las revistas como parámetro para la evaluacion de investigadores e investigaciones

    Directory of Open Access Journals (Sweden)

    K.-F. Kaltenborn

    2004-07-01

    Full Text Available The journal impact factor (IF, which is published annually by the Institute for Scientific Information® (USA, is meanwhile in widespread use as a scientometric parameter for the evaluation of research and researchers in Germany and other European countries. The present article subjects the IF to critical analysis. It first deals with processes of production, transfer, and use of medical knowledge, because the IF intervenes in these processes on account of its reflexivity. Secondary effects of the IF resulting from its reflexivity are discussed with the focus on the level of the author, the journal and the medical discipline as well as on social knowledge processes in society. In addition, the extent to which the IF is appropriate for evaluating the quality of a specific article, of a journal or of individual and collective research achievements is discussed. The present article calls for a research evaluation in accordance with the recommendations of the Deutsche Forschungsgemeinschaft (German Research Council, DFG and of the Arbeitsgemeinschaft der Wissenschaftlichen Medizini-schen Fachgesellschaften (Association of the Scientific Medical Societies, AWMF; and b for more intensive occupation with and organization of medical knowledge processes.El factor de impacto de las revistas (journal impact factor - IF, que publica anualmente el Institute for Scientific Information® (EE.UU., se emplea generalizadamente como parámetro cienciométrico para evaluar las investigaciones y a los investigadores en Alemania y otros países europeos. El presente artículo somete al IF a un análisis crítico. Primero trata de los procesos de producción, comunicación y empleo del conocimiento médico, pues el IF interviene en estos procesos en virtud de su reflexividad. Se exponen los efectos secundarios del IF, que surgen de esta reflexividad, centrándose en el nivel del autor, de la revista y de la disciplina médica, así como en los procesos de conocimiento

  4. Postoperative adjuvant arterial chemoembolization improves survival of hepatocellular carcinoma patients with risk factors for residual tumor:A retrospective control study

    Institute of Scientific and Technical Information of China (English)

    Zheng-Gang Ren; Zhao-You Tang; Zhi-Ying Lin; Jing-Lin Xia; Sheng-Long Ye; Zeng-Chen Ma; Qing-Hai Ye; Lun-Xiu Qin; Zhi-Quan Wu; Jia Fan

    2004-01-01

    AIM: To evaluate the effect of postoperative adjuvant transcatheter arterial chemoembolization (TACE) on the prognosis of hepatocellular carcinoma (HCC) patients with or without risk factors for the residual tumor.METHODS: From January 1995 to December 1998, 549consecutive HCC patients undergoing surgical resection were included in this research. There were 185 patients who underwent surgical resection with adjuvant TACE and 364 patients who underwent surgical resection only. Tumors with a diameter more than 5 cm, multiple nodules, and vascular invasion were defined as risk factors for residual tumor and used for patient stratification. Kaplan-Meier method was used to analyze survival curve and Cox proportional hazard model was used to evaluate the prognostic significance of adjuvant TACE.RESULTS: In the patients without any risk factors for the residual tumor, the 1-, 3-, 5-year survival rates were 93.48%,75.85%, 62.39% in the control group and 97.39%, 70.37%,50.85% in the adjuvant TACE group, respectively. There was no significant difference in the survival between two groups (P = 0.3956). However, in the patients with risk factors for residual tumor, postoperative adjuvant TACE significantly prolonged the patients' survival. There was a statistically significant difference in survival between two groups (P = 0.0216). The 1-, 3-, 5-year survival rates were 69.95%, 49.86%, 37.40% in the control group and 89.67%,61.28%, 44.36% in the adjuvant TACE group, respectively.Cox proportional hazard model showed that tumor diameter and cirrhosis, but not the adjuvant TACE, were the significantly independent prognostic factors in the patients without risk factors for residual tumor. However, in the patients with risk factors for residual tumor adjuvant TACE, and also tumor diameter, AFP level, vascular invasion, were the significantly independent factors associated with the decreasing risk for patients' death from HCC.CONCLUSION: Postoperative adjuvant TACE can prolong the

  5. Differential and Reciprocal Regulation between Hypoxia-inducible Factor-α Subunits and Their Prolyl Hydroxylases in Pulmonary Arteries of Rat with Hypoxia-induced Hypertension

    Institute of Scientific and Technical Information of China (English)

    Yun-Rong CHEN; Ai-Guo DAI; Rui-Cheng HU; Yong-Liang JIANG

    2006-01-01

    Hypoxia-inducible factor (HIF)-α subunits (HIF-1 α, HIF-2α and HIF-3α), which play a pivotal role during the development of hypoxia-induced pulmonary hypertension (HPH), are regulated through posttranslational hydroxylation by their three prolyl hydroxylase domain-containing proteins (PHD1, PHD2 and PHD3). PHDs could also be regulated by HIF. But differential and reciprocal regulation between HIF-α and PHDs during the development of HPH remains unclear. To investigate this problem, a rat HPHmodel was established. Mean pulmonary arterial pressure increased significantly after 7 d of hypoxia. Pulmonary artery remodeling index and right ventricular hypertrophy became evident after 14 d of hypoxia. HIF-1α and HIF-2α mRNA increasedslightly after 7 d of hypoxia, but HIF-3α increased significantly after 3 d of hypoxia. The protein expression levels of all three HIF-α were markedly upregulated after exposure to hypoxia. PHD2 mRNA and protein expression levels were upregulated after 3 d of hypoxia; PHD 1 protein declined after 14 d of hypoxia without significant mRNA changes. PHD3 mRNA and protein were markedly upregulated after 3 d of hypoxia, then the mRNA remained at a high level, but the protein declined after 14 d of hypoxia. In hypoxic animals, HIF-1α proteins negatively correlated with PHD2 proteins, whereas HIF-2α and HIF-3α proteins showed negative correlations with PHD3 and PHD1 proteins, respectively. All three HIF-α proteins were positively correlated with PHD2 and PHD3 mRNA. In the present study, HIF-α subunits and PHDs showed differential and reciprocal regulation, and this might play a key pathogenesis role in hypoxia-induced pulmonary hypertension.

  6. Patología coronaria no arteriosclerótica como causa de muerte súbita en adultos: Casuística del Instituto de Medicina Legal de Valencia (1997-2005 Nonatherosclerotic coronary artery disease presenting as sudden death in adults: Casuistic from the Institute of Legal Medicine of Valencia (Spain (1997-2005

    Directory of Open Access Journals (Sweden)

    F. Carratalá Calvo

    2005-10-01

    Full Text Available Introducción y objetivos. En los países industrializados, la causa más frecuente de muerte súbita cardíaca (MSC en el adulto es la isquemia miocárdica aguda por arterioesclerosis coronaria. Sin embargo, existen otras patologías coronarias, congénitas o adquiridas, que pueden producir isquemia miocárdica y muerte súbita: origen anómalo, hipoplasia, estenosis del ostium, aneurisma, disección, localización alta del ostium, puente miocárdico, vasculitis. El objetivo del presente trabajo es revisar la casuística de este tipo de patología coronaria no arterioesclerótica en las 8003 autopsias realizadas en el Instituto de Medicina Legal de Valencia (IMLV entre los años 1997-2005. Método: Los criterios de inclusión de los casos para este estudio han sido: edad superior a 14 años, patología coronaria no arterioesclerótica como causa de muerte y circunstancias de la muerte compatibles con la definición de muerte súbita. Resultados: Se han encontrado 9 casos de muerte súbita en adultos con patología coronaria no arterioesclerótica como causa de muerte: 2 casos de puente miocárdico, 6 casos de disección coronaria y 1 caso de origen anómalo de coronaria. Conclusiones: La patología coronaria no arterioesclerótica, aunque es poco frecuente como causa de MSC, debemos conocerla y poder diagnosticarla macroscópicamente en la sala de autopsias. Siempre debe descartarse otra posible causa de muerte mediante los estudios complementarios químico-toxicológicos e histopatológicos. Es importante conseguir la máxima información clínica anterior al fallecimiento que pueda ayudar al diagnóstico en vida de este tipo de patologías, ya que en la mayoría de los casos sigue siendo un hallazgo postmortem.Introduction and objectives. Coronary atherosclerosis is the most frequent cause of acute myocardial ischemia and sudden cardiac death in industrialized countries. However, there are others diseases, congenital or acquired, that can

  7. La obesidad como factor desencadenante de la diabetes mellitus tipo II en la población infanto-juvenil de los países desarrollados

    OpenAIRE

    Panero Santos, Laura

    2014-01-01

    La Obesidad infantil es una enfermedad crónica de origen multifactorial que está aumentando su prevalencia en los últimos años, desde 1988 es declarada epidemia global por la OMS. A su vez es causante de enfermedades asociadas como la diabetes Mellitus tipo II, la cual hasta ahora era conocida en la población adulta, sin embargo en los últimos años se ha constatado un aumento de la causística en la pobalción infanto-juvenil. Nos encontramos ante un creciente e importante problema de Salu...

  8. El turismo sostenible como factor de desarrollo económico en el marco de la Unión Europea

    OpenAIRE

    Molina del Pozo, Carlos Francisco

    2009-01-01

    El turismo es uno de los sectores más importantes y en plena expansión de la economía mundial y de la Unión Europea. Muestra de esto son las cifras que alcanza España. Así en 2007, visitaron el país 59,2 millones que significo un volumen de ingresos de 49.946 millones de euros. Pero si bien el turismo es un sector que se presenta como una relevante actividad económica, también es cierto que esta misma actividad puede producir impactos territoriales y medioambientales muy negativos, ...

  9. Estrategia de innovación como factor determinante del éxito de las cooperativas vitivinícolas de Castilla La Mancha

    OpenAIRE

    Fernández Moreno, María Valle; Isidro PEÑA GARCÍA-PARDO

    2009-01-01

    La búsqueda de ventajas competitivas, como una de las principales tareas de la empresa, se ha convertido en un principio de las teorías contemporáneas de dirección estratégica (Teece, Pisano y Shuen, 1997). La innovación facilita la adaptación de la empresa al entorno global competitivo, por lo que representa un papel estratégico en el desempeño empresarial. En este sentido destaca la creciente importancia de la innovación y de la utilización de los activos tecnológicos de la empresa. Precisa...

  10. La lesión medular como factor de riesgo dedisfunción sexual en el varón

    OpenAIRE

    López García-Moreno, Antonio-Miguel

    2013-01-01

    [ES]El objetivo principal de esta tesis fue la comprobación de la existencia de diferencias significativas en el funcionamiento de las vías neurológicas que intervienen en el desarrollo de la función sexual entre pacientes con lesión medular y disfunción sexual y pacientes con disfunción sexual de etiología no neurógena. Como objetivos secundarios se pretende la comprobación de la existencia de diferencias significativas entre ambos grupos de pacientes respecto a la vascularización pene...

  11. Sex hormone binding globulin decrease as potential pathogenetic factor for hirsutism in adolescent girls Disminución de la globulina transportadora de hormonas sexuales como factor patogénico de hirsutismo en la adolescencia

    Directory of Open Access Journals (Sweden)

    Graciela Cross

    2008-04-01

    Full Text Available We investigated 252 non-obese female subjects aged 13-39 years to evaluate if an exaggerated descent of sex hormone binding globulin (SHBG levels during adolescence can play a role in the development of hirsutism. Body hair was assessed according to Ferriman and Gallwey (FG, with a stringent criterion of normality of 4 and controls (FG Se investigaron 252 mujeres con peso normal, de 13 a 39 años de edad, para evaluar si un descenso exagerado en los niveles de la globulina transportadora de hormonas sexuales ("sex hormone binding globulin"; SHBG puede tener un rol en el desarrollo de hirsutismo. Este signo fue evaluado con la escala de Ferriman y Gallwey (FG, empleando un criterio riguroso de normalidad 4 y controles (FG < 4, ciclos menstruales regulares, sin acné. En adolescentes de 15-18 años, los valores de SHBG fueron menores en las "hirsutas", los niveles de FT fueron similares en ambos grupos y el índice de FG correlacionó inversamente con SHBG. En las mujeres de 19-39 años, los niveles de FT fueron mayores en las "hirsutas", los valores de SHBG fueron similares en ambos grupos y FG correlacionó positivamente con FT. Los valores más bajos de SHBG se observaron entre 15 y 18 años, pero la pendiente de disminución a partir de los valores de 13-14 años fue mayor en el grupo de "hirsutas". Los valores de FT se incrementaron progresivamente con la edad, pero el aumento fue mayor en el grupo de "hirsutas". Estos resultados sugieren un rol importante del descenso de SHBG en la adolescencia vs. un incremento más acentuado de los niveles de testosterona en las adultas, como factores que condicionan el desarrollo del hirsutismo en esos dos diferentes periodos de la vida.

  12. Crianças e adolescentes com história familiar de hipertensão arterial: indicadores de risco cardiovasculares Niños y adolescentes con historia familiar de hipertensión arterial: indicadores de riesgo cardiovasculares Children and adolescents with familiar history of high blood pressure: risk factors for cardiovascular diseases

    Directory of Open Access Journals (Sweden)

    Emília Soares Chaves

    2009-12-01

    Full Text Available Objetivo: Identificar emum grupo de crianças e adolescentes com história familiar de hipertensão arterial a presença de indicadores do risco para hipertensão arterial. Métodos: Estudo desenvolvido com 141 indivíduos de seis a 18 anos em uma comunidade de Fortaleza com coleta de dados realizada no domicílio. Resultados: Os indicadores de risco mais presentes foram a ingesta de sal, sedentarismo e ingesta inadequada de legumes. As médias de pressão arterial foram maiores nos indivíduos do sexo masculino. Aqueles que referiram fazer uso de sal na alimentação e não consumir diariamente frutas e legumes apresentaram menores médias. Conclusão: Considera-se a necessidade da identificação precoce de indicadores de risco para hipertensão arterial a fim de prevenir eventos cardiovasculares.Objetivo: Identificar en un grupo de niños y adolescentes con historia familiar de hipertensión arterial, la presencia de indicadores de riesgo para hipertensión arterial. Métodos: estudio desarrollado con 141 individuos de seis a 18 años en una comunidad de la ciudad de Fortaleza con recolección de datos realizada en el domicilio. Resultados: los indicadores de riesgo que aparecieron con más frecuencia fueron la ingestión de sal, sedentarismo y escasa ingestión de legumbres. Los promedios de presión arterial fueron mayores en los individuos del sexo masculino. Aquellos que refirieron hacer uso de sal en la alimentación y no consumir diariamente frutas y legumbres presentaron menores promedios. Conclusión: se considera la necesidad de identificar precozmente los indicadores de riesgo para hipertensión arterial a fin de prevenir eventos cardiovasculares.Objective: To identify the risk factor for cardiovascular diseases among children and adolescents with family history of high blood pressure. Methods: Descriptive Study with 141 individuals aged 6 to 18 years from a community in Fortaleza, Brazil. Data were collected at the participants

  13. The Role of Dermcidin Isoform 2: A Two-Faceted Atherosclerotic Risk Factor for Coronary Artery Disease and the Effect of Acetyl Salicylic Acid on It

    Directory of Open Access Journals (Sweden)

    Rajeshwary Ghosh

    2012-01-01

    Full Text Available Hypertension and diabetes mellitus are considered to be two major atherosclerotic risk factors for coronary artery disease (CAD. A stress-induced protein identified to be dermcidin isoform 2 of Mr. 11 kDa from blood plasma of hypertensive persons when injected (0.1 μM in rabbits increased the systolic pressure by 77% and diastolic pressure by 45% over the controls within 2 h. Ingestion of acetyl salicylic acid (150 mg/70 kg by these subjects reduced systolic (130 mm Hg and diastolic pressures (80 mm Hg with reduction of plasma dermcidin level to normal ranges (9 nM. The protein was found to be a potent activator of platelet cyclooxygenase and inhibited insulin synthesis. Aspirin was found to reduce hypertension by reduction of plasma dermcidin level, neutralized the effect of cyclooxygenase, and restored the pancreatic insulin synthesis through NO synthesis. These results indicated that dermcidin could be a novel atherosclerotic risk factor for its hypertensive and diabetogenic effects.

  14. INVESTIGATION OF THE RISK FACTORS FOR CORONARY ARTERY DISEASES IN EMPLOYEES AND THEIR SPOUSES OF THE ELAZIG SECURITY DEPARTMENT WHO ADMITTED TO MEDICAL DEPARTMENT OF THIS HEADQUARTER

    Directory of Open Access Journals (Sweden)

    Suleyman Erhan DEVECI

    2006-08-01

    Full Text Available This study was carried out with the aim of identifying risk factors coronary artery disease (CAD in the employees of Elazig Security Department. Questionnaires were applied to members and/or spouses (313 individuals of Elazig Security Department admitting to the Health Office for any reason in November-December 2003. Measurements for fasting blood sugar, serum cholesterol levels and blood pressure values were carried out. Of the individuals participating in this study, 1.9% reported having diabetes, 2.9% heart disease and 5.4% hypertension. Mean blood pressure measurements were; systolic 114.1±15.9 and diastolic 74.6±10.3 mmHg, mean fasting blood glucose values were reported as 90.9±16.6 mg/dl. 8.9% had high systolic and 7.7% had high diastolic blood pressure measurements, 16.0% had elevated total cholesterol and 3.5% had elevated fasting blood sugar levels. 36.7% reported to be current smokers, 20.8% reported having regular physical activity. 65.5% reported skipping meals and 47.3% reported eating snacks between the meals. In the group that was analyzed, the rates of smoking, sedentary life style and irregular eating habits that are considered as risk factors for CAD were high. [TAF Prev Med Bull 2006; 5(4.000: 235-243

  15. Fibroblast growth factor 23 is associated with carotid artery calcification in chronic kidney disease patients not undergoing dialysis: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Nakayama Masaru

    2013-01-01

    Full Text Available Abstract Background Fibroblast growth factor 23 (FGF23 is an important hormone in the regulation of phosphate metabolism. It is unclear whether FGF23 is associated with carotid artery calcification (CAAC in predialysis patients. The present study aimed to clarify the relationship between FGF23 and CAAC in patients with chronic kidney disease (CKD who were not on dialysis. Methods One-hundred ninety-five predialysis CKD patients were enrolled in this cross-sectional study. CAAC was assessed using multidetector computed tomography, and the prevalence of CAAC was examined. Intact FGF23 was measured in each patient. The risk factors for CAAC were evaluated using a logistic regression model. Results We found CAAC in 66% of the patients. The prevalence of CAAC significantly increased across CKD stages: it was 37% in CKD stages 1–2, 58% in stage 3; 75% in stage 4, and 77% in stage 5 (p  Conclusions The prevalence of CAAC is increased with the decline in the kidney function. FGF23 is independently related to CAAC in patients with CKD who are not on dialysis.

  16. Genotype–phenotype relationship of F7 R353Q polymorphism and plasma factor VII coagulant activity in Asian Indian families predisposed to coronary artery disease

    Indian Academy of Sciences (India)

    Jayashree Shanker; Ganapathy Perumal; Arindam Maitra; Veena S. Rao; B. K. Natesha; Shibu John; Sridhar Hebbagodi; Vijay V. Kakkar

    2009-12-01

    Elevated factor VII (FVII) level is a risk factor for coronary artery disease (CAD). We investigated the role of R353Q polymorphism in the F7 gene in 139 Indian families with CAD, comprising of 222 affected subjects, 105 unaffected subjects and 126 affected sibling pairs. Plasma per cent FVIIc activity (FVII.c activity) differed significantly across R353Q genotype ($P \\lt 0.0001$). Frequency of subjects with RR and QQ genotypes were higher in 4th quartile and 1st quartile of FVII.c activity, respectively ($P \\lt 0.0001$). F7 R353Q SNP was able to explain up to 7% of variation in FVII.c activity by regression analysis and an additive genetic component of variance of 28.04% by heritability analysis. Quantitative trait loci analysis showed suggestive linkage evidence of F7 SNP with per cent FVII.c activity (LOD score $-1.82$; $P = 0.002$). Individuals with RR and RQ genotypes carried an OR of 2.071 (95% c.i. = 1.506–2.850) and 2.472 (95% c.i. = 1.679–3.641), respectively, towards CAD risk. There was significant correlation of FVII.c activity with lipid markers, particularly among those with RR and RQ genotype after covariate adjustment. In conclusion, the F7 R353Q SNP appears to moderately influence plasma FVII.c activity and risk of CAD in Indians.

  17. Microglia and macrophages express tumor necrosis factor receptor p75 following middle cerebral artery occlusion in mice

    DEFF Research Database (Denmark)

    Lambertsen, Kate Lykke; Clausen, Bettina Hjelm; Fenger, Claus;

    2007-01-01

    The proinflammatory and potential neurotoxic cytokine tumor necrosis factor (TNF) is produced by activated CNS resident microglia and infiltrating blood-borne macrophages in infarct and peri-infarct areas following induction of focal cerebral ischemia. Here, we investigated the expression of the ...

  18. Carotid Artery Screening

    Science.gov (United States)

    ... Resources Professions Site Index A-Z Carotid Artery Screening What is carotid artery screening? Who should consider ... about carotid artery screening? What is carotid artery screening? Screening examinations are tests performed to find disease ...

  19. Evaluating the Incidence of Cognitive Disorder Following Off-Pump Coronary Artery Bypasses Surgery and its Predisposing Factors

    OpenAIRE

    Joudi, Marjan; Fathi, Mehdi; Harati, Hadi; Joudi, Mitra; Izanloo, Azra; Rahdari, Ali; Soltani, Ghasem

    2014-01-01

    Background: Cognitive disorder is a fluctuating cognitive destruction and a common problem for hospitalized patients, which leads to loss of consciousness. It is usually accompanied with increased mortality, prolonged hospital stay, and decreased rehabilitation. Objectives: The purpose of this study was to determine risk factors associated with cognitive disorder after open-heart surgery. Patients and Methods: In total, 171 patients who had undergone off-pump open-heart surgery and lacked any...

  20. Tumor necrosis factor-alpha G-238A polymorphism and coronary artery disease risk: a meta-analysis of 4,222 patients and 4,832 controls

    Directory of Open Access Journals (Sweden)

    Hua XP

    2015-09-01

    Full Text Available Xian-Ping Hua,1,* Xiao-Dong Zhang,2,* Joey SW Kwong,3,* Xian-Tao Zeng,4 Zhen-Jian Zhang,1 Wan-Lin Wei21Department of Cardiology, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei Province, 2Department of Cardiology and 4th Cadres Ward, General Hospital of Beijing Military Command, Beijing, 3Chinese Evidence-Based Medicine Center and Chinese Cochrane Center, West China Hospital, Sichuan University, Chengdu, 4Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan, People’s Republic of China*These authors contributed equally to this workBackground: The aim of the present study was to investigate the association between tumor necrosis factor-alpha (TNF-α gene G-238A polymorphism and risk of coronary artery disease (CAD using a meta-analytical approach.Methods: The PubMed and Embase databases were searched for relevant publications up to January 13, 2015. Four authors (XPH, XDZ, XTZ, and ZJZ independently selected the studies, extracted, and analyzed the data using the Comprehensive Meta-Analysis software. The sensitivity and subgroups analyses were also performed. Either a fixed effects or a random effects model was used to estimate pooled odds ratios (ORs and their 95% confidence intervals (CIs.Results: Finally, ten articles including eleven case-control studies involving 4,222 patients and 4,832 controls were yielded. The results indicated no significant association between G-238A polymorphism and CAD risk (A vs G: OR =1.08, 95% CI =0.89–1.30; AA vs GG: OR =1.15, 95% CI =0.59–2.25; GA vs GG: OR =1.14, 95% CI =0.88–1.48; AA vs [GG + GA]: OR =1.09, 95% CI =0.56–2.14; (GA + AA vs GG: OR =1.11, 95% CI =0.90–1.38. In the subgroup analyses, similar results were obtained with overall populations. The sensitivity analyses showed that the overall results were robust. No publication bias was detected.Conclusion: Based on current evidence, we can conclude that TNF-α G-238A polymorphism

  1. Fatores de risco para acidente vascular encefálico após cirurgia de revascularização do miocárdio Risk factors for stroke after coronary artery bypass grafting

    Directory of Open Access Journals (Sweden)

    Dinaldo Cavalcanti de Oliveira

    2008-10-01

    Full Text Available FUNDAMENTO: O acidente vascular encefálico (AVE é uma temida complicação após cirurgia de revascularização do miocárdio (CRM, com incidência entre 1,3% e 4,3%. OBJETIVO: Identificar fatores preditores de AVE após CRM, na era moderna da cirurgia cardíaca. MÉTODOS: Este é um estudo caso-controle de 65 pares de pacientes, no qual o pareamento foi realizado por sexo, idade (+ 3 anos e data da CRM (+ 3 meses. Os casos são pacientes submetidos à CRM eletiva com circulação extracorpórea (CEC, que apresentaram AVE (definido como déficit clínico neurológico até 24 horas de pós-operatório e confirmado por exame de imagem, e os controles aqueles submetidos à CRM eletiva com CEC sem AVE. RESULTADOS: A análise univariada revelou que o número de vasos revascularizados foi associado com a ocorrência de AVE após a CRM (3 ± 0,8 vs. 2,76 ± 0,8, p = 0,01. Na análise multivariada por regressão logística condicional, a hipertensão arterial sistêmica [OR: 6,1 (1,5 - 24, p = 0,009] e o diabete melito [OR: 3,1 (1,09 - 11, p= 0,03] foram determinantes de maior chance de AVE após CRM, e o infarto agudo do miocárdio > 1 mês determinante de menor chance [OR: 0,1 (0,03 - 0,36, p = 0,003]. CONCLUSÃO: Hipertensão e diabete melito foram identificados como preditores independentes de AVE nas primeiras 24 horas de pós-operatório de CRM. Em pacientes com tais fatores de risco, é possível que o conhecimento dos mecanismos causadores da injúria cerebral represente uma estratégia capaz de diminuir a incidência de AVE após CRM.BACKGROUND: Stroke is a feared complication after coronary artery bypass grafting surgery (CABG, with an incidence between 1.3 and 4.3%. OBJECTIVE: To identify predictive factors for stroke after CABG in the modern era of cardiac surgery. METHODS: This is a case-control study of 65 pairs of patients, paired by sex, age (+ 3 years and date of CABG (+ 3 months. The cases were patients submitted to elective CABG

  2. New assessment for the risk of ischemic stroke or carotid artery stenosis. Prognostic factor analysis in hypercholesterolemia patients

    International Nuclear Information System (INIS)

    Concise and non-invasive methods to detect the risk of cerebrovascular disease in high risk patients are considered useful. The purpose of this pilot study was to evaluate the contribution to ischemic cerebrovascular risk of the Revised Atherosclerotic Index (RAI) which is calculated from the Atherogenic Index (AI), patient's age and number of risk factors of atherosclerotic disease. I studied retrospectively the serum lipid levels, carotid stenosis measured by ultrasonography and cerebral infarction diagnosed from the symptoms and CT in 56 hypercholesterolemic outpatients. I assessed the relation between the RAI and carotid stenoic findings, history of cerebral infarction, and type of cerebral infarction. I also assessed the relation between the RAI and changes in LDL-cholesterol level before and after atorvastatin administration. The RAI was significantly increased in patients with carotid lesions and cerebral infarction, but the AI was not. While the odds ratio of the AI for carotid lesions was high but not significantly so, that of the RAI increased with statistical significance. The odds ratio for cerebral infarction was high for the RAI but not for the AI. Furthermore, the RAI was significantly high in patients with aortic thrombotic cerebral infarction as compared to that in patients without any infarction. The serum lipids were well controlled under administration of atorvastatin and the mean RAI was also significantly decreased; however, more comprehensive control of risk factors might be necessary. The AI adjusted for patient's age and number of risk factors might be useful for assessing the risk of carotid lesion atherosclerosis and aortic thrombotic cerebral infarction. (author)

  3. Ischemia reperfusion of the hepatic artery induces the functional damage of large bile ducts by changes in the expression of angiogenic factors.

    Science.gov (United States)

    Mancinelli, Romina; Glaser, Shannon; Francis, Heather; Carpino, Guido; Franchitto, Antonio; Vetuschi, Antonella; Sferra, Roberta; Pannarale, Luigi; Venter, Julie; Meng, Fanyin; Alpini, Gianfranco; Onori, Paolo; Gaudio, Eugenio

    2015-12-01

    Liver transplantation and cholangiocarcinoma induce biliary dysfunction following ischemia reperfusion (IR). The function of the intrahepatic biliary tree is regulated by both autocrine and paracrine factors. The aim of the study was to demonstrate that IR-induced damage of cholangiocytes is associated with altered expression of biliary angiogenic factors. Normal and bile duct ligation rats underwent 24-h sham or hepatic reperfusion after 30 min of transient occlusion of the hepatic artery (HAIR) or portal vein (PVIR) before collecting liver blocks and cholangiocyte RNA or protein. We evaluated liver histology, biliary apoptosis, proliferation and expression of VEGF-A/C, VEGFR-2/3, Ang-1/2, and Tie-1/2 in liver sections and isolated small and large cholangiocytes. Normal rat intrahepatic cholangiocyte cultures (NRICC) were maintained under standard conditions in normoxic or under a hypoxic atmosphere for 4 h and then transferred to normal conditions for selected times. Subsequently, we measured changes in biliary proliferation and apoptosis and the expression of VEGF-A/C and VEGFR-2/3. In vivo, HAIR (but not PVIR) induced damage of large bile ducts and decreased proliferation and secretin-stimulated cAMP levels. HAIR-induced damage of large bile ducts was associated with increased expression of VEGF-A/C, VEGFR-2/3, Ang-1/2, and Tie-1/2. In vitro, under hypoxic conditions, there was increased apoptosis and reduced proliferation of NRICC concomitant with enhanced expression of VEGF-A/C and VEGFR-2/3. The functional damage of large bile ducts by HAIR and hypoxia is associated with increased expression of angiogenic factors in small cholangiocytes, presumably due to a compensatory mechanism in response to biliary damage. PMID:26451003

  4. Effects of Qigong Exercise on Biomarkers and Mental and Physical Health in Adults With at Least One Risk Factor for Coronary Artery Disease.

    Science.gov (United States)

    Hung, Hsuan-Man; Yeh, Shu-Hui; Chen, Chung-Hey

    2016-05-01

    Current medical technology permits the early detection of risk factors for coronary artery disease (CAD) in adults, and interventions are available to prevent CAD-related morbidity and mortality. The goal of this study was to determine the effectiveness of a Qigong exercise intervention in improving biomarker levels and mental and physical health outcomes in community-dwelling adults diagnosed with CAD risk factors, in a southern Taiwanese city. Participants were randomly assigned to an experimental (n= 84) group that participated in a 60-min Qigong group session 3 times per week for 3 months or a control (n= 61) group that did not receive the intervention. Self-perceived mental and physical health assessed with the Chinese Health Questionnaire-12, and body fat percentage were measured at baseline and 6, 12, and 16 weeks. Blood samples were collected at baseline and 12 weeks for analysis of lipid profiles, high-sensitivity C-reactive protein (hs-CRP), glycated hemoglobin (HbA1c), and fasting plasma sugar. Linear mixed model analyses revealed that experimental participants had significantly improved perceived mental and physical health and body fat percentage compared to the control group at 6 and 12 weeks but not 16 weeks. The lipid profiles were significantly more improved in the Qigong group than in the control group at 12 weeks. Qigong exercise, however, had no significant effects on hs-CRP, HbA1c, or fasting plasma sugar. Findings suggest that Qigong exercise improves a limited number of CAD risk factors in community-dwelling adults aged 40 years and over. PMID:26590130

  5. Sex differences in intracranial arterial bifurcations

    DEFF Research Database (Denmark)

    Lindekleiv, Haakon M; Valen-Sendstad, Kristian; Morgan, Michael K; Mardal, Kent-Andre; Faulder, Kenneth; Magnus, Jeanette H; Waterloo, Knut; Romner, Bertil; Ingebrigtsen, Tor

    2010-01-01

    Subarachnoid hemorrhage (SAH) is a serious condition, occurring more frequently in females than in males. SAH is mainly caused by rupture of an intracranial aneurysm, which is formed by localized dilation of the intracranial arterial vessel wall, usually at the apex of the arterial bifurcation. T...... female preponderance is usually explained by systemic factors (hormonal influences and intrinsic wall weakness); however, the uneven sex distribution of intracranial aneurysms suggests a possible physiologic factor-a local sex difference in the intracranial arteries....

  6. TUBERCULOSIS COMO ENFERMEDAD OCUPACIONAL

    Science.gov (United States)

    Mendoza-Ticona, Alberto

    2014-01-01

    Existe evidencia suficiente para declarar a la tuberculosis como enfermedad ocupacional en diversos profesionales especialmente entre los trabajadores de salud. En el Perú están normados y reglamentados los derechos laborales inherentes a la tuberculosis como enfermedad ocupacional, como la cobertura por discapacidad temporal o permanente. Sin embargo, estos derechos aún no han sido suficientemente socializados. En este trabajo se presenta información sobre el riesgo de adquirir tuberculosis en el lugar de trabajo, se revisan las evidencias para declarar a la tuberculosis como enfermedad ocupacional en trabajadores de salud y se presenta la legislación peruana vigente al respecto. PMID:22858771

  7. Usos y tendencias adictivas de una muestra de estudiantes universitarios españoles a la red social Tuenti: la actitud positiva hacia la presencia de la madre en la red como factor protector

    Directory of Open Access Journals (Sweden)

    Mercedes Durán

    2015-01-01

    Full Text Available El objetivo de este trabajo fue estudiar, desde el paradigma de usos y gratificaciones, el uso que los estudiantes universitarios españoles (N = 221 hacen de la red social Tuenti, y en qué medida estos usos se asocian con sus niveles de adicción a dicha red social. Además se analizó el papel que los progenitores tienen como facilitadores o inhibidores de dichas tendencias adictivas y el impacto del género. Los resultados muestran cuatro categorías de usos de la red Tuenti: entretenimiento, comunicación a través del muro, comunicación a nivel privado e información social. Además, la actitud positiva hacia la presencia de la madre en la red Tuenti se muestra como un factor de protección de las tendencias adictivas a la red. Por último, se han encontrado diferencias estadísticamente significativas en función del género, tanto en los usos que realizan chicos y chicas, como en sus patrones de adicción a la red Tuenti, de tal manera que los chicos informan de niveles de adicción superiores a los informados por las chicas en el uso de esta red social.

  8. Determination of arterial wall shear stress

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The arteries can remodel their structure and function to adapt themselves to the mechanical environment. In various factors that lead to vascular remodeling, the shear stress on the arterial wall induced by the blood flow is of great importance. However, there are many technique difficulties in measuring the wall shear stress directly at present. In this paper, through analyzing the pulsatile blood flow in arteries, a method has been proposed that can determine the wall shear stress quantitatively by measuring the velocity on the arterial axis, and that provides a necessary means to discuss the influence of arterial wall shear stress on vascular remodeling.

  9. Arterial Switch Operation in Patients with Intramural Coronary Artery: Early and Mid-term Results

    OpenAIRE

    Kim, HyungTae; Sung, Si Chan; Kim, Si-Ho; Chang, Yun Hee; Ahn, Hyo Yeong; Lee, Hyoung Doo

    2011-01-01

    Background The intramural coronary artery has been known as a risk factor for early death after an arterial switch operation (ASO). We reviewed the morphological characteristics and evaluated the early and mid-term results of ASO for patients with an intramural coronary artery. Materials and Methods From March 1994 to September 15th 2010, 158 patients underwent ASO at Dong-A and Pusan National University Hospitals for repair of transposition of the great arteries and double outlet right ventr...

  10. Diferencia veno-arterial de dióxido de carbono como predictor de gasto cardiaco disminuido en modelo pediátrico experimental Veno-arterial difference of carbondioxide as a predictor of low cardiac output in an experimental pediatric model

    Directory of Open Access Journals (Sweden)

    Franco Díaz

    2012-01-01

    Full Text Available Background: Cardiac output (CO measurement is not a standard of care for critically ill children, but it can be estimated by indirect methods such as veno-arterial pCO2 difference (ΔVACO2. Aim: To determine the correlation between CO and ΔVACO2 and evaluate the usefulness of ΔVACO2 in the diagnosis of low CO in an experimental pediatric model. Materials and Methods: Thirty piglets weighing 4.8 ± 0.35 kg were anesthetized and monitored with transpulmonary thermodilution. Lung injury was induced with tracheal instillation of Tween 20®. Serial measurements of central venous and arterial blood gases, as well as CO, were obtained at baseline, 1, 2 and 4 h after lung injury induction. Low cardiac output (LCO was defined as CO lower than 2.5 Llminlm². Results: There was an inverse correlation between CO and ΔVACO2 (r = -0.36, p < 0.01. ΔVACO2 was 14 ± 8 mmHg in LCO state and 8 ± 6 mmHg when this condition was not present (p < 0.01. Area under the receiver operating characteristic (ROC curves of ΔVACO2 and LCO state was 0.78 (0.68-0.86. The best cut-point was 8.9 mmHg to determine LCO with a sensibility 0.78, specificity 0.7, positive predictive value 0.27 and negative predictive value 0.96. Conclusions: In this model there was an inverse correlation between ΔVACO2 and CO. The best cutoff value to discard LCO was ΔVACO2 of 8.9 mmHg, indicating that under this value the presence of LCO is very unlikely.

  11. Los factores organizacionales y del entorno como moderadores de la relación entre innovación y desempeño empresarial: diferencias entre pequeñas y grandes empresas

    OpenAIRE

    García Zamora, Evelyn

    2012-01-01

    [ES] Busca medir la relación entre innovación y desempeño empresarial añadiendo distintos factores organizacionales (tamaño, orientación al mercado, orientación emprendedora) y del entorno (turbulencia del entorno, intensidad competitiva, colaboración empresarial), como condicionantes del éxito y/o moderadores, que interactúan en la implementación de la innovación. Aporta evidencia sobre los siguientes aspectos: que la innovación conduce a la mejora del desempeño empresarial, el papel del tam...

  12. Imagen corporal como factor de riesgo en los trastornos de la alimentación: una comparación transcultural entre México y España

    OpenAIRE

    G. GÓMEZ PERESMITRE; M. V. ACOSTA GARCIA

    2000-01-01

    El presente estudio tuvo como objetivo analizar factores de riesgo en trastornos de la alimentación, asociados con imagen corporal y con conducta alimentaria en muestras de mujeres estudiantes igualadas en edad y de diferentes culturas: la española y la mexicana. Los resultados se discuten a la luz de lo que nos aporta la literatura transcultural, y entre los hallazgos más importantes, se encontró que las mexicanas comparten un prototipo ideal de imagen corporal y que ante las mismas situacio...

  13. O outsourcing dos sistemas de informação como factor de competitividade no sector da banca El outsourcing de sistemas de información como factor de competitividad en el sector bancario The outsourcing of information systems as a factor of competitiveness in the banking sector

    Directory of Open Access Journals (Sweden)

    Renato Lopes da Costa

    2010-09-01

    Full Text Available Numa era de competição particularmente intensa, a externalização dos sistemas de informação (SI está a tornar-se cada vez mais numa importante componente na tomada de decisão estratégica e uma importante forma de aumentar a eficiência e qualidade nas várias actividades empresariais, sendo visto por muitos gestores como uma ferramenta influenciadora e poderosa de mudança organizacional (Ferfusson, 1996, trazendo uma vida nova à organização e à cadeia processual da empresa. O que se pretende neste artigo é exactamente enfatizar o real valor desta moderna ferramenta de gestão estratégica, mostrando que o potenciamento das tecnologias de informação de gestão (TIG, quando combinadas com o outsourcing são, de facto, uma inevitabilidade virtual que tende a ganhar cada vez mais espaço no contexto empresarial, podendo esta visão ampla de negócio fomentar criatividade e dinamismo nas operações das organizações na mesma linha do que tem vindo a ser realizado a este nível pelo sector bancário.En una era de competencia especialmente intensa, la externalización de los sistemas de información (SI se está convirtiendo en un componente cada vez más importante en la toma de decisiones estratégicas y de una forma importante de aumentar la eficiencia y calidad en las diferentes actividades empresariales, siendo vista por muchos directivos como una herramienta influyente y poderosa para el cambio organizacional (Ferfusson, 1996, trayendo una nueva vida a la organización y la cadena de procesos de la empresa. El propósito de este artículo es precisamente hacer hincapié en el valor real de esta moderna herramienta de gestión estratégica, demostrando que las potencialidades de la tecnología de gestión de la información (TIC cuando se combina con el “Outsourcing” es en realidad una inevitabilidad virtual que tiende a ganar cada día más espacio en el contexto empresarial, y que esta visión amplia del negocio pueda

  14. Expression of Drug-Resistant Factor Genes in Hepatocellular Carcinoma Patients Undergoing Chemotherapy with Platinum Complex by Arterial Infusion

    Directory of Open Access Journals (Sweden)

    Shiro Ueda

    2010-09-01

    Full Text Available This study investigated gene expression of drug resistance factors in biopsy tissue samples from hepatocellular carcinoma (HCC patients undergoing chemotherapy by platinum complex. Liver biopsy was performed to collect tissue from the tumor site (T and the non-tumor site (NT prior to the start of treatment. For drug-resistant factors, drug excretion transporters cMOAT and MDR-1, intracellular metal binding protein MT2, DNA repair enzyme ERCC-l and inter-nucleic cell transport protein MVP, were investigated. The comparison of the expression between T and NT indicated a significant decrease of MT2 and MDR-1 in T while a significant increase in ERCC-1 was noted in T. Further, expression was compared between the response cases and non-response cases using the ratios of expression in T to those in NT. The response rate was significantly low in the high expression group when the cutoff value of cMOAT and MT2 was set at 1.5 and 1.0, respectively. Furthermore, when the patients were classified into A group (cMOAT ≧ 1.5 or MT2 ≧ 1.0 and B group (cMOAT < 1.5 and MT2 < 1.0, the response rate of A group was significantly lower than B group when we combined the cutoff values of cMOAT and MT2. It is considered possible to estimate the therapeutic effect of platinum complex at a high probability by combining the expression condition of these two genes.

  15. Morbilidad oculta de hipertensión arterial en adolescentes

    Directory of Open Access Journals (Sweden)

    Oneida Terazón Miclín

    2013-12-01

    Full Text Available Se llevó a cabo una investigación descriptiva y transversal de 85 alumnos del séptimo grado (en las edades de 10-15 años de la Escuela Secundaria Básica "Roberto Rodríguez" de Santiago de Cuba, durante el 2010, para determinar la morbilidad oculta de hipertensión arterial en estos adolescentes. Del total de alumnos estudiados, se obtuvo que 5,9 % presentaba hipertensión arterial y se mantenían asintomáticos en esos momentos; además, existían factores de riesgo asociados a la enfermedad, como el antecedente familiar de primera línea de padecer la entidad clínica, los hábitos tóxicos, la dieta inadecuada y la obesidad. Los adolescentes fueron remitidos a consulta de pediatría para que se les realizara el estudio pertinente. Finalmente se concluyó que existía morbilidad oculta de hipertensión arterial en los adolescentes de este centro escolar, asociada a factores genéticos y ambientales (entre otros, de los cuales, algunos pudieran ser modificados con una adecuada educación a la familia y a los jóvenes afectados.

  16. Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age.

    Science.gov (United States)

    Rać, Monika Ewa; Suchy, Janina; Kurzawski, Grzegorz; Kurlapska, Agnieszka; Safranow, Krzysztof; Rać, Michał; Sagasz-Tysiewicz, Dagmara; Krzystolik, Andrzej; Poncyljusz, Wojciech; Jakubowska, Katarzyna; Olszewska, Maria; Krupa, Beata; Chlubek, Dariusz

    2012-02-01

    This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age. The study group consisted of 90 patients; the men were ≤ 50 years old and the women were ≤ 55 years old. Amplicons of exons 4 and 5 including fragments of introns were analyzed by DHPLC. Two polymorphisms were found: IVS3-6 T/C (rs3173798) and IVS4-10 G/A (rs3211892). The C allele of the IVS3-6 T/C polymorphism was associated with higher prevalence of obesity and diabetes, higher hsCRP, lower Lp(a) serum concentrations, and younger age at myocardial infarction. The A allele of the IVS4-10 G/A polymorphism was associated with older age of myocardial infarction and higher white blood cell count. The functional role of CD36 polymorphisms in CAD development needs further research. PMID:22113854

  17. On the Effects of Several Factors on Arterial Blood Pressure%几种因素对人体动脉血压的影响

    Institute of Scientific and Technical Information of China (English)

    郭增平

    2012-01-01

    对衡水学院大学生,在肢体运动、冰水、不同体重指数等情况下和安静状态下的动脉血压采用常规方法进行测量、记录数据并进行统计学处理.结果表明,血压与肢体运动、冰水及体重指数等因素有非常明显的联系(P〈0.01),这些都会影响人体血压;控制体重、饮食、多进行有氧运动以及养成良好的生活习惯是预防和减少大学生高血压的主要措施.%The arterial blood pressure of the students from Hengshui University in both the state of body movement,cool water and different body mass index(BMI) and the state of resting is measured,recorded and analyzed by statistics.Results show that blood pressure has an obvious connection with body movement,cool water,BMI and other factors,which can affect the blood pressure(P0.01).The major measures for college students to prevent and reduce hypertension are to control weight and diet,take aerobic exercise and develop healthy living habits.

  18. La historia familiar y la conducta de consumo de alcohol como factor sociocultural en el adolescente. Perspectiva de enfermería

    OpenAIRE

    Nora Angélica Armendáriz-García; Jessica Belem Almanza-López; María Teresa de Jesús Alonso-Castillo; Nora Nelly Oliva-Rodríguez; María Magdalena Alonso-Castillo; Manuel Antonio López-Cisneros

    2015-01-01

    Los adolescentes con mayor probabilidad de presentar la conducta de consumo de alcohol son los que están sometidos a diferentes factores de riesgo, los cuales pueden ser personales; dentro de estos factores se encuentra la historia familiar de consumo de alcohol (HFCA). Objetivo: establecer las diferencias y la relación entre el factor personal sociocultural a través de la HFCA y la conducta no sa- ludable de consumo de alcohol en adolescentes de preparatoria del Estado de Nuevo León. Ma...