7 CFR 29.1168 - Nondescript (N Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Nondescript (N Group). 29.1168 Section 29.1168... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.1168 Nondescript (N Group). Extremely common tobacco... other group except Scrap. Grades, Grade Names, Minimum Specifications, and Tolerances N1L— Best...

E(7) symmetric area of the black hole horizon

International Nuclear Information System (INIS)

Kallosh, R.; Kol, B.

1996-01-01

Extreme black holes with 1/8 of unbroken N=8 supersymmetry are characterized by the nonvanishing area of the horizon. The central charge matrix has four generic eigenvalues. The area is proportional to the square root of the invariant quartic form of E 7(7) . It vanishes in all cases when 1/4 or 1/2 of supersymmetry is unbroken. The supergravity nonrenormalization theorem for the area of the horizon in the N=8 case protects the unique U-duality invariant. copyright 1996 The American Physical Society

Sodium channel Nav1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome

Directory of Open Access Journals (Sweden)

Yiangou Yiangos

2010-06-01

Full Text Available Abstract Background Voltage gated sodium channels Nav1.7 are involved in nociceptor nerve action potentials and are known to affect pain sensitivity in clinical genetic disorders. Aims and Objectives To study Nav1.7 levels in dental pulpitis pain, an inflammatory condition, and burning mouth syndrome (BMS, considered a neuropathic orofacial pain disorder. Methods Two groups of patients were recruited for this study. One group consisted of patients with dental pulpitis pain (n = 5 and controls (n = 12, and the other patients with BMS (n = 7 and controls (n = 10. BMS patients were diagnosed according to the International Association for the Study of Pain criteria; a pain history was collected, including the visual analogue scale (VAS. Immunohistochemistry with visual intensity and computer image analysis were used to evaluate levels of Nav1.7 in dental pulp tissue samples from the dental pulpitis group, and tongue biopsies from the BMS group. Results There was a significantly increased visual intensity score for Nav1.7 in nerve fibres in the painful dental pulp specimens, compared to controls. Image analysis showed a trend for an increase of the Nav1.7 immunoreactive % area in the painful pulp group, but this was not statistically significant. When expressed as a ratio of the neurofilament % area, there was a strong trend for an increase of Nav1.7 in the painful pulp group. Nav1.7 immunoreactive fibres were seen in abundance in the sub-mucosal layer of tongue biopsies, with no significant difference between BMS and controls. Conclusion Nav1.7 sodium channel may play a significant role in inflammatory dental pain. Clinical trials with selective Nav1.7 channel blockers should prioritise dental pulp pain rather than BMS.

Sodium channel Nav1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome

Science.gov (United States)

2010-01-01

Background Voltage gated sodium channels Nav1.7 are involved in nociceptor nerve action potentials and are known to affect pain sensitivity in clinical genetic disorders. Aims and Objectives To study Nav1.7 levels in dental pulpitis pain, an inflammatory condition, and burning mouth syndrome (BMS), considered a neuropathic orofacial pain disorder. Methods Two groups of patients were recruited for this study. One group consisted of patients with dental pulpitis pain (n = 5) and controls (n = 12), and the other patients with BMS (n = 7) and controls (n = 10). BMS patients were diagnosed according to the International Association for the Study of Pain criteria; a pain history was collected, including the visual analogue scale (VAS). Immunohistochemistry with visual intensity and computer image analysis were used to evaluate levels of Nav1.7 in dental pulp tissue samples from the dental pulpitis group, and tongue biopsies from the BMS group. Results There was a significantly increased visual intensity score for Nav1.7 in nerve fibres in the painful dental pulp specimens, compared to controls. Image analysis showed a trend for an increase of the Nav1.7 immunoreactive % area in the painful pulp group, but this was not statistically significant. When expressed as a ratio of the neurofilament % area, there was a strong trend for an increase of Nav1.7 in the painful pulp group. Nav1.7 immunoreactive fibres were seen in abundance in the sub-mucosal layer of tongue biopsies, with no significant difference between BMS and controls. Conclusion Nav1.7 sodium channel may play a significant role in inflammatory dental pain. Clinical trials with selective Nav1.7 channel blockers should prioritise dental pulp pain rather than BMS. PMID:20529324

EPA Region 7 Aquatic Focus Areas (ECO_RES.R7_AQUATIC_FOCUS_AREAS)

Data.gov (United States)

U.S. Environmental Protection Agency — This shapefile consists of 347 individual Aquatic Ecological System (AES) polygons that are the Aquatic Conservation Focus Areas for EPA Region 7. The focus areas...

36 CFR 7.69 - Ross Lake National Recreation Area.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Ross Lake National Recreation... INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.69 Ross Lake National Recreation Area... snowmobiles the following locations within the Ross Lake National Recreation Area: (1) State Highway 20, that...

Modified two-fluid model for the two-group interfacial area transport equation

International Nuclear Information System (INIS)

Sun Xiaodong; Ishii, Mamoru; Kelly, Joseph M.

2003-01-01

This paper presents a modified two-fluid model that is ready to be applied in the approach of the two-group interfacial area transport equation. The two-group interfacial area transport equation was developed to provide a mechanistic constitutive relation for the interfacial area concentration in the two-fluid model. In the two-group transport equation, bubbles are categorized into two groups: spherical/distorted bubbles as Group 1 while cap/slug/churn-turbulent bubbles as Group 2. Therefore, this transport equation can be employed in the flow regimes spanning from bubbly, cap bubbly, slug to churn-turbulent flows. However, the introduction of the two groups of bubbles requires two gas velocity fields. Yet it is not practical to solve two momentum equations for the gas phase alone. In the current modified two-fluid model, a simplified approach is proposed. The momentum equation for the averaged velocity of both Group-1 and Group-2 bubbles is retained. By doing so, the velocity difference between Group-1 and Group-2 bubbles needs to be determined. This may be made either based on simplified momentum equations for both Group-1 and Group-2 bubbles or by a modified drift-flux model

Feedback from visual cortical area 7 to areas 17 and 18 in cats: How neural web is woven during feedback.

Science.gov (United States)

Yang, X; Ding, H; Lu, J

2016-01-15

To investigate the feedback effect from area 7 to areas 17 and 18, intrinsic signal optical imaging combined with pharmacological, morphological methods and functional magnetic resonance imaging (fMRI) was employed. A spatial frequency-dependent decrease in response amplitude of orientation maps was observed in areas 17 and 18 when area 7 was inactivated by a local injection of GABA, or by a lesion induced by liquid nitrogen freezing. The pattern of orientation maps of areas 17 and 18 after the inactivation of area 7, if they were not totally blurred, paralleled the normal one. In morphological experiments, after one point at the shallow layers within the center of the cat's orientation column of area 17 was injected electrophoretically with HRP (horseradish peroxidase), three sequential patches in layers 1, 2 and 3 of area 7 were observed. Employing fMRI it was found that area 7 feedbacks mainly to areas 17 and 18 on ipsilateral hemisphere. Therefore, our conclusions are: (1) feedback from area 7 to areas 17 and 18 is spatial frequency modulated; (2) feedback from area 7 to areas 17 and 18 occurs mainly ipsilaterally; (3) histological feedback pattern from area 7 to area 17 is weblike. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

7 CFR 29.6128 - Straight Stripped (X Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Straight Stripped (X Group). 29.6128 Section 29.6128... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.6128 Straight Stripped (X Group). This group consists of..., and tolerances X1 Fine Quality Straight Stripped. Heavy, ripe, firm, semielastic, normal strength and...

Splitting of 9-iodo-1,7-carborane by potassium hydroxide in butanol with butoxy group substitution for iodine atom when formation of anions of 1-butoxy- and 5-butoxy-nido-7,9-dicarbaundecaborate

International Nuclear Information System (INIS)

Zakharkin, L.I.; Ol'shevskaya, V.A.; Guseva, V.V.; Panfilova, S.Yu.

2000-01-01

The 9-iodo-1,7-carborane by heating in the potassium hydroxide butanol solution is splitted into the stereoisomeric anions of the nido-7,9-dicarbaundecaborate substituting under the reaction conditions the butoxy-group for iodine atom with formation of anions of the 1-butoxy- and -butoxy-nido-7,9-dicarbaundecaborate [ru

Site characterization plan for groundwater in Waste Area Grouping 1 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

Energy Technology Data Exchange (ETDEWEB)

Lee, R.R.; Curtis, A.H.; Houlberg, L.M.; Purucker, S.T.; Singer, M.L.; Tardiff, M.F.; Wolf, D.A.

1994-07-01

The Waste Area Grouping (WAG) 1 Groundwater Operable Unit (OU) at Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee, is undergoing a site characterization to identify environmental contamination that may be present. This document, Site Characterization Report for Groundwater in Waste Area Grouping I at Oak Ridge National Laboratory, Oak Ridge, Tennessee, identifies areas of concern with respect to WAG 1 groundwater and presents the rationale, justification, and objectives for conducting this continuing site characterization. This report summarizes the operations that have taken place at each of the areas of concern in WAG 1, summarizes previous characterization studies that have been performed, presents interpretations of previously collected data and information, identifies contaminants of concern, and presents an action plan for further site investigations and early actions that will lead to identification of contaminant sources, their major groundwater pathways, and reduced off-site migration of contaminated groundwater to surface water. Site characterization Activities performed to date at WAG I have indicated that groundwater contamination, principally radiological contamination, is widespread. An extensive network of underground pipelines and utilities have contributed to the dispersal of contaminants to an unknown extent. The general absence of radiological contamination in surface water at the perimeter of WAG 1 is attributed to the presence of pipelines and underground waste storage tank sumps and dry wells distributed throughout WAG 1 which remove more than about 40 million gal of contaminated groundwater per year.

Site characterization plan for groundwater in Waste Area Grouping 1 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Lee, R.R.; Curtis, A.H.; Houlberg, L.M.; Purucker, S.T.; Singer, M.L.; Tardiff, M.F.; Wolf, D.A.

1994-07-01

The Waste Area Grouping (WAG) 1 Groundwater Operable Unit (OU) at Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee, is undergoing a site characterization to identify environmental contamination that may be present. This document, Site Characterization Report for Groundwater in Waste Area Grouping I at Oak Ridge National Laboratory, Oak Ridge, Tennessee, identifies areas of concern with respect to WAG 1 groundwater and presents the rationale, justification, and objectives for conducting this continuing site characterization. This report summarizes the operations that have taken place at each of the areas of concern in WAG 1, summarizes previous characterization studies that have been performed, presents interpretations of previously collected data and information, identifies contaminants of concern, and presents an action plan for further site investigations and early actions that will lead to identification of contaminant sources, their major groundwater pathways, and reduced off-site migration of contaminated groundwater to surface water. Site characterization Activities performed to date at WAG I have indicated that groundwater contamination, principally radiological contamination, is widespread. An extensive network of underground pipelines and utilities have contributed to the dispersal of contaminants to an unknown extent. The general absence of radiological contamination in surface water at the perimeter of WAG 1 is attributed to the presence of pipelines and underground waste storage tank sumps and dry wells distributed throughout WAG 1 which remove more than about 40 million gal of contaminated groundwater per year

Idaho National Engineering Laboratory Waste Area Groups 1-7 and 10 Technology Logic Diagram. Volume 3

Energy Technology Data Exchange (ETDEWEB)

O`Brien, M.C.; Meservey, R.H.; Little, M.; Ferguson, J.S.; Gilmore, M.C.

1993-09-01

The Idaho National Engineering Laboratory (INEL) Technology Logic Diagram (TLD) was developed to provide a decision support tool that relates Environmental Restoration (ER) and Waste Management (WM) problems at the INEL to potential technologies that can remediate these problems. The TLD identifies the research, development, demonstration, testing, and evaluation needed to develop these technologies to a state that allows technology transfer and application to an environmental restoration need. It is essential that follow-on engineering and system studies be conducted to build on the output of this project. These studies will begin by selecting the most promising technologies identified in this TLD and finding an optimum mix of technologies that will provide a socially acceptable balance between cost and risk to meet the site windows of opportunity. The TLD consists of three separate volumes: Volume I includes the purpose and scope of the TLD, a brief history of the INEL Waste Area Groups, and environmental problems they represent. A description of the TLD, definitions of terms, a description of the technology evaluation process, and a summary of each subelement, is presented. Volume II describes the overall layout and development of the TLD in logic diagram format. This section addresses the environmental restoration of contaminated INEL sites. Volume III (this volume) provides the Technology Evaluation Data Sheets (TEDS) for Environmental Restoration and Waste Management (EM) activities that are reference by a TEDS code number in Volume II. Each of these sheets represents a single logic trace across the TLD. These sheets contain more detail than provided for technologies in Volume II. Data sheets are arranged alphanumerically by the TEDS code number in the upper right corner of each sheet.

Working Group 7 Summary

Energy Technology Data Exchange (ETDEWEB)

Nagaitsev S.; Berg J.

2012-06-10

The primary subject of working group 7 at the 2012 Advanced Accelerator Concepts Workshop was muon accelerators for a muon collider or neutrino factory. Additionally, this working group included topics that did not fit well into other working groups. Two subjects were discussed by more than one speaker: lattices to create a perfectly integrable nonlinear lattice, and a Penning trap to create antihydrogen.

Waste site grouping for 200 Areas soil investigations

International Nuclear Information System (INIS)

1997-01-01

The purpose of this document is to identify logical waste site groups for characterization based on criteria established in the 200 Areas Soil Remediation Strategy (DOE-RL 1996a). Specific objectives of the document include the following: finalize waste site groups based on the approach and preliminary groupings identified in the 200 Areas Soil Remediation Strategy; prioritize the waste site groups based on criteria developed in the 200 Areas Soil Remediation Strategy; select representative site(s) that best represents typical and worse-case conditions for each waste group; develop conceptual models for each waste group. This document will serve as a technical baseline for implementing the 200 Areas Soil Remediation Strategy. The intent of the document is to provide a framework, based on waste site groups, for organizing soil characterization efforts in the 200 Areas and to present initial conceptual models

The complete genomic sequence of lytic bacteriophage gh-1 infecting Pseudomonas putida--evidence for close relationship to the T7 group

International Nuclear Information System (INIS)

Kovalyova, Irina V.; Kropinski, Andrew M.

2003-01-01

The genome of the lytic Pseudomonas putida bacteriophage gh-1 is linear double-stranded DNA containing 37,359 bp with 216-bp direct terminal repeats. Like other members of the T7 group, the gh-1 genome contains regions of high homology to T7 interspersed with nonhomologous regions that contain small open reading frames of unknown function. The genome shares 31 genes in common with other members of the T7 group, including RNA polymerase, and an additional 12 unique putative genes. A major difference between gh-1 and other members of this group is the absence of any open reading frames between the left direct terminal repeat and gene 1. Sequence analysis of the gh-1 genome also revealed the presence of 10 putative phage promoters with a consensus sequence similar to the promoters of T3 and phiYeO3-12 (consensus: TAAAAACCCTCACTRTGGCHSCM). P. putida mutants resistant to gh-1 were demonstrated to have an altered lipopolysaccharide structure, indicating that members of this group use lipopolysaccharide as their cellular receptor

Fermi Large Area Telescope Observations of the Supernova Remnant G8.7-0.1

Energy Technology Data Exchange (ETDEWEB)

Ajello, M.; Allafort, A.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Baldini, L.; /INFN, Pisa; Ballet, J.; /AIM, Saclay; Barbiellini, G.; /INFN, Trieste /Trieste U.; Bastieri, D.; /INFN, Padua /Padua U.; Bechtol, K.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Bellazzini, R.; /INFN, Pisa; Berenji, B.; Blandford, R.D.; Bloom, E.D.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Bonamente, E.; /INFN, Perugia /Perugia U.; Borgland, A.W.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Bregeon, J.; /INFN, Pisa; Brigida, M.; /Bari Polytechnic /INFN, Bari; Bruel, P.; /Ecole Polytechnique; Buehler, R.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Buson, S.; /INFN, Padua /Padua U.; Caliandro, G.A.; /CSIC, Catalunya; Cameron, R.A.; /Stanford U., HEPL /KIPAC, Menlo Park /SLAC; Caraveo, P.A.; /IASF, Milan /AIM, Saclay /INFN, Perugia /Perugia U. /Stanford U., HEPL /KIPAC, Menlo Park /SLAC /Unlisted, US /Naval Research Lab, Wash., D.C. /Perugia U. /ASDC, Frascati /Stanford U., HEPL /KIPAC, Menlo Park /SLAC /Montpellier U. /ASDC, Frascati /Udine U. /INFN, Trieste /Bari Polytechnic /INFN, Bari /Naval Research Lab, Wash., D.C. /Stanford U., HEPL /KIPAC, Menlo Park /SLAC /Bari Polytechnic /INFN, Bari /Ecole Polytechnique /NASA, Goddard /Stanford U., HEPL /KIPAC, Menlo Park /SLAC /Udine U. /INFN, Trieste /Trieste Observ. /Hiroshima U. /Nagoya U. /Bari Polytechnic /INFN, Bari /INFN, Bari /ASDC, Frascati /INFN, Perugia /Perugia U. /Bari Polytechnic /INFN, Bari /ASDC, Frascati /Bari Polytechnic /INFN, Bari /Bologna Observ. /Stanford U., HEPL /KIPAC, Menlo Park /SLAC /Naval Research Lab, Wash., D.C. /Alabama U., Huntsville /CSIC, Catalunya /Hiroshima U. /NASA, Goddard /Hiroshima U.; /more authors..

2012-09-14

We present a detailed analysis of the GeV gamma-ray emission toward the supernova remnant (SNR) G8.7-0.1 with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. An investigation of the relationship between G8.7-0.1 and the TeV unidentified source HESS J1804-216 provides us with an important clue on diffusion process of cosmic rays if particle acceleration operates in the SNR. The GeV gamma-ray emission is extended with most of the emission in positional coincidence with the SNR G8.7-0.1 and a lesser part located outside the western boundary of G8.7-0.1. The region of the gamma-ray emission overlaps spatially connected molecular clouds, implying a physical connection for the gamma-ray structure. The total gamma-ray spectrum measured with LAT from 200 MeV-100 GeV can be described by a broken power-law function with a break of 2.4 {+-} 0.6 (stat) {+-} 1.2 (sys) GeV, and photon indices of 2.10 {+-} 0.06 (stat) {+-} 0.10 (sys) below the break and 2.70 {+-} 0.12 (stat) {+-} 0.14 (sys) above the break. Given the spatial association among the gamma rays, the radio emission of G8.7-0.1, and the molecular clouds, the decay of p0s produced by particles accelerated in the SNR and hitting the molecular clouds naturally explains the GeV gamma-ray spectrum. We also find that the GeV morphology is not well represented by the TeV emission from HESS J1804-216 and that the spectrum in the GeV band is not consistent with the extrapolation of the TeV gamma-ray spectrum. The spectral index of the TeV emission is consistent with the particle spectral index predicted by a theory that assumes energy-dependent diffusion of particles accelerated in an SNR. We discuss the possibility that the TeV spectrum originates from the interaction of particles accelerated in G8.7-0.1 with molecular clouds, and we constrain the diffusion coefficient of the particles.

Fermi Large Area Telescope Observations of the Supernova Remnant G8.7-0.1

International Nuclear Information System (INIS)

2012-01-01

We present a detailed analysis of the GeV gamma-ray emission toward the supernova remnant (SNR) G8.7-0.1 with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. An investigation of the relationship between G8.7-0.1 and the TeV unidentified source HESS J1804-216 provides us with an important clue on diffusion process of cosmic rays if particle acceleration operates in the SNR. The GeV gamma-ray emission is extended with most of the emission in positional coincidence with the SNR G8.7-0.1 and a lesser part located outside the western boundary of G8.7-0.1. The region of the gamma-ray emission overlaps spatially connected molecular clouds, implying a physical connection for the gamma-ray structure. The total gamma-ray spectrum measured with LAT from 200 MeV-100 GeV can be described by a broken power-law function with a break of 2.4 ± 0.6 (stat) ± 1.2 (sys) GeV, and photon indices of 2.10 ± 0.06 (stat) ± 0.10 (sys) below the break and 2.70 ± 0.12 (stat) ± 0.14 (sys) above the break. Given the spatial association among the gamma rays, the radio emission of G8.7-0.1, and the molecular clouds, the decay of p0s produced by particles accelerated in the SNR and hitting the molecular clouds naturally explains the GeV gamma-ray spectrum. We also find that the GeV morphology is not well represented by the TeV emission from HESS J1804-216 and that the spectrum in the GeV band is not consistent with the extrapolation of the TeV gamma-ray spectrum. The spectral index of the TeV emission is consistent with the particle spectral index predicted by a theory that assumes energy-dependent diffusion of particles accelerated in an SNR. We discuss the possibility that the TeV spectrum originates from the interaction of particles accelerated in G8.7-0.1 with molecular clouds, and we constrain the diffusion coefficient of the particles.

26 CFR 1.1081-7 - Sale of stock or securities received upon exchange by members of system group.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Sale of stock or securities received upon.... Orders § 1.1081-7 Sale of stock or securities received upon exchange by members of system group. (a... which are members of the same system group consists of stock or securities issued by the corporation...

7 CFR 407.17 - Group risk plan for wheat.

Science.gov (United States)

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Group risk plan for wheat. 407.17 Section 407.17..., DEPARTMENT OF AGRICULTURE GROUP RISK PLAN OF INSURANCE REGULATIONS § 407.17 Group risk plan for wheat. The provisions of the Group Risk Plan for Wheat for the 2000 and succeeding crop years are as follows: 1...

7 CFR 407.11 - Group risk plan for corn.

Science.gov (United States)

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Group risk plan for corn. 407.11 Section 407.11..., DEPARTMENT OF AGRICULTURE GROUP RISK PLAN OF INSURANCE REGULATIONS § 407.11 Group risk plan for corn. The provisions of the Group Risk Plan for Corn for the 2000 and succeeding crop years are as follows: 1...

7 CFR 29.6020 - Group.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Group. 29.6020 Section 29.6020 Agriculture Regulations... INSPECTION Standards Definitions § 29.6020 Group. A type division consisting of one or more grades based on the general quality of tobacco. Groups in these types are: Binder (B), Stripper (C), Straight Stripped...

7 CFR 29.2275 - Group.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Group. 29.2275 Section 29.2275 Agriculture Regulations... INSPECTION Standards Official Standard Grades for Virginia Fire-Cured Tobacco (u.s. Type 21) § 29.2275 Group... usually related to stalk position, body, or the general quality of the tobacco. Groups in this type are...

7 CFR 29.1026 - Group.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Group. 29.1026 Section 29.1026 Agriculture Regulations... Type 92) § 29.1026 Group. A division of a type covering closely related grades based on certain characteristics which are related to stalk position, body, or the general quality of the tobacco. Groups in Flue...

7 CFR 29.3523 - Group.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Group. 29.3523 Section 29.3523 Agriculture Regulations... Type 95) § 29.3523 Group. A division of a type covering closely related grades based on certain characteristics which are related to stalk position, body, or the general quality of the tobacco. Groups in Dark...

7 CFR 29.3031 - Group.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Group. 29.3031 Section 29.3031 Agriculture Regulations... Group. A division of a type covering closely related grades based on certain characteristics which are related to stalk position or the general quality of the tobacco. Groups in Burley, Types 31 and 93, are as...

7 CFR 29.2526 - Group.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Group. 29.2526 Section 29.2526 Agriculture Regulations...-Cured Tobacco (u.s. Types 22, 23, and Foreign Type 96) § 29.2526 Group. A division of a type covering..., or the general quality of the tobacco. Groups in these types are Wrappers (A), Heavy Leaf (B), Thin...

Development of two-group interfacial area transport equation for confined flow-2. Model evaluation

International Nuclear Information System (INIS)

Sun, Xiaodong; Kim, Seungjin; Ishii, Mamoru; Beus, Stephen G.

2003-01-01

The bubble interaction mechanisms have been analytically modeled in the first paper of this series to provide mechanistic constitutive relations for the two-group interfacial area transport equation (IATE), which was proposed to dynamically solve the interfacial area concentration in the two-fluid model. This paper presents the evaluation approach and results of the two-group IATE based on available experimental data obtained in confined flow, namely, 11 data sets in or near bubbly flow and 13 sets in cap-turbulent and churn-turbulent flow. The two-group IATE is evaluated in steady state, one-dimensional form. Also, since the experiments were performed under adiabatic, air-water two-phase flow conditions, the phase change effect is omitted in the evaluation. To account for the inter-group bubble transport, the void fraction transport equation for Group-2 bubbles is also used to predict the void fraction for Group-2 bubbles. Agreement between the data and the model predictions is reasonably good and the average relative difference for the total interfacial area concentration between the 24 data sets and predictions is within 7%. The model evaluation demonstrates the capability of the two-group IATE focused on the current confined flow to predict the interfacial area concentration over a wide range of flow regimes. (author)

FERMI LARGE AREA TELESCOPE OBSERVATIONS OF THE SUPERNOVA REMNANT G8.7–0.1

International Nuclear Information System (INIS)

Ajello, M.; Allafort, A.; Bechtol, K.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Buehler, R.; Cameron, R. A.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Buson, S.; Bonamente, E.; Brigida, M.; Bruel, P.; Caliandro, G. A.

2012-01-01

We present a detailed analysis of the GeV gamma-ray emission toward the supernova remnant (SNR) G8.7–0.1 with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. An investigation of the relationship between G8.7–0.1 and the TeV unidentified source HESS J1804–216 provides us with an important clue on diffusion process of cosmic rays if particle acceleration operates in the SNR. The GeV gamma-ray emission is extended with most of the emission in positional coincidence with the SNR G8.7–0.1 and a lesser part located outside the western boundary of G8.7–0.1. The region of the gamma-ray emission overlaps spatially connected molecular clouds, implying a physical connection for the gamma-ray structure. The total gamma-ray spectrum measured with LAT from 200 MeV-100 GeV can be described by a broken power-law function with a break of 2.4 ± 0.6 (stat) ± 1.2 (sys) GeV, and photon indices of 2.10 ± 0.06 (stat) ± 0.10 (sys) below the break and 2.70 ± 0.12 (stat) ± 0.14 (sys) above the break. Given the spatial association among the gamma rays, the radio emission of G8.7–0.1, and the molecular clouds, the decay of π 0 s produced by particles accelerated in the SNR and hitting the molecular clouds naturally explains the GeV gamma-ray spectrum. We also find that the GeV morphology is not well represented by the TeV emission from HESS J1804–216 and that the spectrum in the GeV band is not consistent with the extrapolation of the TeV gamma-ray spectrum. The spectral index of the TeV emission is consistent with the particle spectral index predicted by a theory that assumes energy-dependent diffusion of particles accelerated in an SNR. We discuss the possibility that the TeV spectrum originates from the interaction of particles accelerated in G8.7–0.1 with molecular clouds, and we constrain the diffusion coefficient of the particles.

7 CFR 959.4 - Production area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Production area. 959.4 Section 959.4 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE ONIONS GROWN IN SOUTH TEXAS Order Regulating Handling Definitions § 959.4 Production area. Production area means the counties of Val Verde...

7 CFR 956.4 - Production area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Production area. 956.4 Section 956.4 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE SWEET ONIONS GROWN IN THE WALLA WALLA VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Definitions § 956.4 Production area. Production area...

Black holes and groups of type 7

Indian Academy of Sciences (India)

Supergravity; groups of type 7; black holes; quantum field theory. ... representation are reviewed, along with a connection between special Kähler geometry and a 'generalization' of groups of type 7. ... Pramana – Journal of Physics | News.

7 CFR 955.4 - Production area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Production area. 955.4 Section 955.4 Agriculture... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE VIDALIA ONIONS GROWN IN GEORGIA Definitions § 955.4 Production area. Production area means that part of the State of Georgia enclosed by the...

7 CFR 1940.959 - Area plan.

Science.gov (United States)

2010-01-01

..., and time lines based on a realistic assessment of the area, including, but not limited to, the... possibilities for industrial recruitment in the area; (5) The potential for development of tourism in the area... expansion of existing businesses; and (7) The potential to produce value-added agricultural products in the...

A modified two-fluid model for the application of two-group interfacial area transport equation

International Nuclear Information System (INIS)

Sun, X.; Ishii, M.; Kelly, J.

2003-01-01

This paper presents the modified two-fluid model that is ready to be applied in the approach of the two-group interfacial area transport equation. The two-group interfacial area transport equation was developed to provide a mechanistic constitutive relation for the interfacial area concentration in the two-fluid model. In the two-group transport equation, bubbles are categorized into two groups: spherical/distorted bubbles as Group 1 while cap/slug/churn-turbulent bubbles as Group 2. Therefore, this transport equation can be employed in the flow regimes spanning from bubbly, cap bubbly, slug to churn-turbulent flows. However, the introduction of the two groups of bubbles requires two gas velocity fields. Yet it is not desirable to solve two momentum equations for the gas phase alone. In the current modified two-fluid model, a simplified approach is proposed. The momentum equation for the averaged velocity of both Group-1 and Group-2 bubbles is retained. By doing so, the velocity difference between Group-1 and Group-2 bubbles needs to be determined. This may be made either based on simplified momentum equations for both Group-1 and Group-2 bubbles or by a modified drift-flux model

7 CFR 1160.115 - Milk marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Milk marketing area. 1160.115 Section 1160.115 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing... Order Definitions § 1160.115 Milk marketing area. Milk marketing area means each area within which milk...

7 CFR 29.2440 - (N Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false (N Group). 29.2440 Section 29.2440 Agriculture... INSPECTION Standards Grades § 29.2440 (N Group). Extremely common tobacco which does not meet the minimum specifications or which exceeds the tolerance of the lowest grade of any other group except scrap. U.S. grades...

7 CFR 634.1 - Purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Purpose and scope. 634.1 Section 634.1 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL CLEAN WATER PROGRAM General § 634.1 Purpose and scope. (a) The purpose... from agricultural activities. The proposed project area must be within a high priority area in an...

New perspectives for "non-classical" molecules: heavy [1.1.1]propellanes of group 14.

Science.gov (United States)

Nied, Dominik; Breher, Frank

2011-07-01

Heavy analogues of hydrocarbons intrigue chemists for a number of reasons, not least because they are often fundamentally different from their carbon counterparts and have remained a challenge for both experimentalists and theoreticians for a long time. The appealing properties of [1.1.1]propellanes of group 14 consisting of inverted tetrahedral bridgehead atoms can mainly be attributed to the particular bonding between the latter. More than 20 years after the first member of this family has been published, several contributions to this area have impressively extended the spectrum of these so-called main-group biradicaloids. Still in its infancy, further perspectives for these "non-classical" molecules are now arising. In this tutorial review, early findings and recent developments in this area are presented. Particular attention is drawn on the relationship of unusual structures and unusual reactivities of main-group element compounds in general and in particular of heavy propellane scaffolds of group 14.

Summary of Working Group 7 on 'Exotic acceleration schemes'

International Nuclear Information System (INIS)

Tajima, T.

2001-01-01

Exotic concepts of advanced acceleration technologies have been explored by Group 7 under the leadership of T. Tajima and T. Smith (who could not attend) at the AAC. Explored concepts are: (1) proton (ion) acceleration by laser, (2) additional ion acceleration methods, (3) crystal x-rays and acceleration, (4) vacuum acceleration, (5) active medium acceleration, and (6) some advanced methods in laser wakefield. The first subject of laser photon acceleration was discussed jointly with Group 1 and in the end the participants came to an agreement on the mechanism of proton acceleration by laser irradiation

Magic clusters and (2x1) local structure formed in a half-unit cell of the Si(1 1 1)-(7x7) surface by Tl adsorption

International Nuclear Information System (INIS)

Kocan, P.; Visikovskiy, A.V.; Ohira, Y.; Yoshimura, M.; Ueda, K.; Tochihara, H.

2008-01-01

Formation of a (2x1) local structure is found at submonolayer growth of Tl on the Si(1 1 1)-(7x7) surface by means of scanning tunneling microscopy (STM). At low coverages, the (7x7) grid remains and the (2x1) structure is formed inside of the half-unit cells of the (7x7). The (2x1) coexists with other structures, such as of 'magic' clusters observed in the case of all other group III metals. Based on our STM observations we propose an atomic arrangement of the (2x1) structure

Exposure To Violence And Occupational Satisfaction Of Health Personnal In A Health Group Area

Directory of Open Access Journals (Sweden)

Elcin Balci

2011-02-01

Full Text Available Purpose: In this study, it evaluted that exposure to violence and effect of this exposure to occupational satisfaction of health personel in Melikgazi Health Group Area. Materials And Methods: This cross sectional and descriptive study was performed in April-May 2006. Sampling not planned, it assumed to reach all of health personel. Data were analysed using computer and chi square test were used for statistical analyses. Lesser than 0,05 values were accepted as statistically significant. Results: Of the research group 66,7 % were female and 33,3 % were male. Mean age was 34,48 ± 5,73 years. Of the study participants were working in health center, 80,4 % day time and 19,6 % in night time and mean duration of working was 11,99 ± 5,3 years. Of the study group 57,1 % were chosen profession willingly and 65,5 % of them didn’t want to their children chose same profession. Of the study group 68,2 % were thought their fare were not enough. Of the study group, 50,3 % were experinced verbal and/or physical violence with different degrees. Of the violence victims 63,6 % were working in night shift of health centers and most of them doctors. Conclusion: Exposure to violence during work effects the satisfaction negativeley. [TAF Prev Med Bull 2011; 10(1.000: 13-18

7 CFR 29.1167 - Mixed (M Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Mixed (M Group). 29.1167 Section 29.1167 Agriculture... INSPECTION Standards Grades § 29.1167 Mixed (M Group). This group consists of tobacco from three or more groups or two distinctly different groups which are mixed together in various combinations. Grades, Grade...

7 CFR 29.1036 - Mixed Group (M).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Mixed Group (M). 29.1036 Section 29.1036 Agriculture... Type 92) § 29.1036 Mixed Group (M). This group consists of tobacco from three or more groups or two distinctly different groups which are mixed together in various combinations. [49 FR 16755, Apr. 20, 1984...

Group velocity tomography and regionalization in Italy and bordering areas

International Nuclear Information System (INIS)

Pontevivo, A.; Panza, G.F.

2001-10-01

More than one hundred group velocity dispersion curves of the fundamental mode of Rayleigh waves have been processed to obtain tomographic maps, in the period range from 10 s to 35 s, for the Italian peninsula and bordering areas. We compute average dispersion relations over a 1 deg. x 1 deg. grid, and, since the lateral resolving power of our data set is about 200 km, we group the cells of the grid accordingly to their dispersion curves. In this way and without a priori geological constraints, we define seven different regions, each characterised by a distinctive mean group velocity dispersion curve. The resulting regionalization can be easily correlated with the main tectonic features of the study area and mimics a recently proposed structural sketch. Average models of the shear wave velocity in the crust and in the upper mantle for a few selected regions are presented. The very low S-wave velocity values found in the uppermost upper mantle of the Southern Tyrrhenian basin are consistent with a large percentage of partial melting, well in agreement with the presence of the Vavilov-Magnaghi and Marsili huge volcanic bodies. (author)

7 CFR 29.1166 - Primings (P Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Primings (P Group). 29.1166 Section 29.1166... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.1166 Primings (P Group). This group consists of round-tipped leaves from the lowest portion of the stalk. Leaves of the P group ripen prematurely as a result...

Knowledge and Attitude of Married Women in the Reproductive Age Group Regarding Emergency Contraception in Selected Rural Areas of Udupi District

Directory of Open Access Journals (Sweden)

Preethi Fernandes

2014-01-01

Full Text Available Background: Unwanted pregnancy is still a major problem in the modern world despite the widely available contraception services. This study was conducted to determine the knowledge and attitude of married women in the reproductive age group regarding emergency contraception in selected rural areas of Udupi district, India. Material and Methods: The study group comprised of 350 married women in the reproductive age group residing in rural areas of Udupi district, India. A structured questionnaire and an attitude scale were used to assess the knowledge and the attitude. Results: Majority, 69.1% of the married women belonged to Hindu religion, 46.9% had an educational qualification of 10th standard and below. About 13.1% of the married women had undergone abortion. Nearly 96.9% of the married women had heard about emergency contraceptives and only 2% of the married women had used emergency contraceptive pills. About 63.7% out of 339 married women had got information about emergency contraceptive pills from health personnel and about 77.7% from television. Majority 84% had poor knowledge on emergency contraception. About 99.7% had favourable attitude on the use of emergency contraceptives. There was a significant association between knowledge scores and selected variable like education, knowledge and the attitude scores had a correlation. Conclusion: The study identifies the knowledge and attitude of the rural married women regarding emergency contraception, hence to help them to plan future pregnancies and prevent any unwanted or unintended pregnancies.

7 CFR 51.45 - Fees and charges at shipping point areas.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Fees and charges at shipping point areas. 51.45 Section 51.45 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE..., AND STANDARDS) Regulations 1 Schedule of Fees and Charges at Shipping Point Areas § 51.45 Fees and...

7 CFR 29.2661 - Wrappers (A Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Wrappers (A Group). 29.2661 Section 29.2661... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2661 Wrappers (A Group). This group consists of leaves usually grown at or above the center portion of the stalk. Cured leaves of this group are elastic and show...

7 CFR 29.2436 - Wrappers (A Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Wrappers (A Group). 29.2436 Section 29.2436... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2436 Wrappers (A Group). This group consists of leaves usually grown at or above the center portion of the stalk. Cured leaves of the A group show a low...

7 CFR 301.38-3 - Protected areas.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Protected areas. 301.38-3 Section 301.38-3 Agriculture..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Black Stem Rust § 301.38-3 Protected areas. (a) The Administrator may designate as a protected area in paragraph (d) of this section any State that has eradicated...

7 CFR 29.1162 - Leaf (B Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Leaf (B Group). 29.1162 Section 29.1162 Agriculture... INSPECTION Standards Grades § 29.1162 Leaf (B Group). This group consists of leaves normally grown at or above the midportion of the stalk. Leaves of the B group have a pointed tip, tend to fold, usually are...

7 CFR 29.1164 - Cutters (C Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Cutters (C Group). 29.1164 Section 29.1164 Agriculture... INSPECTION Standards Grades § 29.1164 Cutters (C Group). This group consists of leaves normally grown at or just below the midportion of the stalk. Leaves of the C group have a tendency to roll concealing the...

7 CFR 29.1165 - Lugs (X Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Lugs (X Group). 29.1165 Section 29.1165 Agriculture... INSPECTION Standards Grades § 29.1165 Lugs (X Group). This group consists of leaves normally grown near the bottom of the stalk. Leaves of the X group usually have a blunt tip and open face; they show some ground...

Mixed Waste Focus Area Working Group: An Integrated Approach to Mercury Waste Treatment and Disposal. Revision 1

International Nuclear Information System (INIS)

Morris, M.I.; Conley, T.B.; Osborne-Lee, I.W.

1997-01-01

May 1996, the U.S. Department of Energy (DOE) Mixed Waste Focus Area (MWFA) initiated the Mercury Work Group (HgWG). The HgWG was established to address and resolve the issues associated with Mercury- contaminated mixed wastes (MWs). During the initial technical baseline development process of the MWFA, three of the top four technology deficiencies identified were related to (1) amalgamation, (2) stabilization, and (3) separation and removal for the treatment of mercury and mercury-contaminated mixed waste (MW). The HgWG is assisting the MWFA in soliciting, identifying, initiating, and managing efforts to address these needs

7 CFR 29.2439 - Lugs (X Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Lugs (X Group). 29.2439 Section 29.2439 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Standards Grades § 29.2439 Lugs (X Group). This group consists of leaves that normally grow near...

7 CFR 29.3155 - Mixed (M Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Mixed (M Group). 29.3155 Section 29.3155 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Standards Grades § 29.3155 Mixed (M Group). This group consists of tobacco of distinctly different...

Roentgenologic characteristic of 7 group contingent of dispensary registration

International Nuclear Information System (INIS)

Derzhavin, V.I.; Nalivajko, N.N.; Kozlova, L.N.; Petrik, R.N.

1984-01-01

9694 persons of 7 group contingent of dispensary registration were examined. Roentgenologic study of posttuberculous changes of 7 group contingent of dispensary registration showed that in people of 7-A subgroup prevail processes of secondary genesis (79.4%) and in people of 7-B subgroup - of primary genesis (55.8%). Consequences of secondary tuberculosis are most recurring

Effects of a paraspinal-lumbar tape application during 7 days on the perceived area of tape contact.

Science.gov (United States)

Funk, Stefan; Finke, Roy; Zeh, Stefan; Siebert, Tobias; Puta, Christian

2017-05-01

The study aimed to investigate the changes of the perceived area of tape contact during a lumbar tape application that lasted 7 days. Single group, repeated measures study. University research laboratory. Twenty-three healthy collegiate students in sports science. Perceived area of tape contact was collected by preparing a drawing of their individual perceived tape outline into a printed body image. Measurements were obtained immediately after fixation of the tape (day 0), at day 3 and day 7 during application and 5 min after the release of the application (day 7). There was no significant change of the perceived area of tape contact after 3 days of tape application. A significant decrease in the perceived area of tape contact was detected 7 days after application (p area of tape contact of healthy sport students is decreased at 7 days. This effect could not be observed at 3 days. These results provide relevant information for the use of elastic tapes concerning the duration of application in medical therapy. Copyright © 2016 Elsevier Ltd. All rights reserved.

7 CFR 1032.2 - Central marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Central marketing area. 1032.2 Section 1032.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE CENTRAL MARKETING AREA Order Regulating...

7 CFR 1007.2 - Southeast marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Southeast marketing area. 1007.2 Section 1007.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE SOUTHEAST MARKETING AREA Order Regulating...

7 CFR 1126.2 - Southwest marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Southwest marketing area. 1126.2 Section 1126.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE SOUTHWEST MARKETING AREA Order Regulating...

7 CFR 1005.2 - Appalachian marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Appalachian marketing area. 1005.2 Section 1005.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE APPALACHIAN MARKETING AREA Order...

7 CFR 1001.2 - Northeast marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Northeast marketing area. 1001.2 Section 1001.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE NORTHEAST MARKETING AREA Order Regulating...

7 CFR 1006.2 - Florida marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Florida marketing area. 1006.2 Section 1006.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE FLORIDA MARKETING AREA Order Regulating...

7 CFR 1033.2 - Mideast marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Mideast marketing area. 1033.2 Section 1033.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE MIDEAST MARKETING AREA Order Regulating...

7 CFR 1131.2 - Arizona marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Arizona marketing area. 1131.2 Section 1131.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE ARIZONA MARKETING AREA Order Regulating...

Validation of the 172 group ENDFB7GX library

International Nuclear Information System (INIS)

Khan, Suhail Ahmad; Raj, Devesh; Karthikeyan, R.; Jagannathan, V.

2007-01-01

Full text: Five 172 group libraries, viz., IAEAGX, ENDFB6GX, JENDL3GX, JEFF31GX, and LWRPSGX were obtained as a part of the IAEA WIMS Library Update Project (WLUP). The first four libraries have data available for 173 nuclides up to 244 Cm. The LWRPSGX library based on JEFF3.1 point dataset is an extended library up to 252 Cf. Data for 12 more actinides and the related burnup chain were added. The five libraries were validated against known experiments in an earlier work. In general the LWRPSGX was found to be giving better results. Recently another version of 172 group library 'ENDFB7GX' has been released. In the present work we provide the results of validation of the ENDFB7GX library against the same set of experimental data and a comparison with results of other libraries. The experimental configuration data include a variety of uniform lattices with enriched UO 2 , U- metal, mixed oxide (UO 2 -PuO 2 ) fuels with H 2 O and D 2 O moderators for a wide range of enrichment, fuel diameter and ratio of moderator to fuel volume (V m /V f ). The calculations have been done using the code LATTEST which solves the single pin lattice cell problem by 1-D multi-group transport theory after cylindricalising the square or hexagonal cell boundary. The LATTEST code is an improved version of the MURLI code and is capable of providing a ready testing of any new cross section library against a set of experimental benchmark lattices collected from various sources. The calculated k eff values and certain spectral indices, where available, have been compared for all the libraries for more than hundred critical lattices. There is a general under prediction of k eff values by all libraries. The maximum under prediction is for ENDFB6GX library and the least is for JENDL3GX library. The ENDFB7GX library, in general, is found to over predict in comparison to the k eff values obtained using LWRPSGX library. While scrutinizing the basic nuclear data it was noted that the slowing down cross

7 CFR 7.1 - Administration.

Science.gov (United States)

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Administration. 7.1 Section 7.1 Agriculture Office of the Secretary of Agriculture SELECTION AND FUNCTIONS OF AGRICULTURAL STABILIZATION AND CONSERVATION STATE, COUNTY AND COMMUNITY COMMITTEES § 7.1 Administration. (a) The regulations of this part are...

Two-group modeling of interfacial area transport in large diameter channels

Energy Technology Data Exchange (ETDEWEB)

Schlegel, J.P., E-mail: schlegelj@mst.edu [Department of Mining and Nuclear Engineering, Missouri University of Science and Technology, 301 W 14th St., Rolla, MO 65409 (United States); Hibiki, T.; Ishii, M. [School of Nuclear Engineering, Purdue University, 400 Central Dr., West Lafayette, IN 47907 (United States)

2015-11-15

Highlights: • Implemented updated constitutive models and benchmarking method for IATE in large pipes. • New model and method with new data improved the overall IATE prediction for large pipes. • Not all conditions well predicted shows that further development is still required. - Abstract: A comparison of the existing two-group interfacial area transport equation source and sink terms for large diameter channels with recently collected interfacial area concentration measurements (Schlegel et al., 2012, 2014. Int. J. Heat Fluid Flow 47, 42) has indicated that the model does not perform well in predicting interfacial area transport outside of the range of flow conditions used in the original benchmarking effort. In order to reduce the error in the prediction of interfacial area concentration by the interfacial area transport equation, several constitutive relations have been updated including the turbulence model and relative velocity correlation. The transport equation utilizing these updated models has been modified by updating the inter-group transfer and Group 2 coalescence and disintegration kernels using an expanded range of experimental conditions extending to pipe sizes of 0.304 m [12 in.], gas velocities of up to nearly 11 m/s [36.1 ft/s] and liquid velocities of up to 2 m/s [6.56 ft/s], as well as conditions with both bubbly flow and cap-bubbly flow injection (Schlegel et al., 2012, 2014). The modifications to the transport equation have resulted in a decrease in the RMS error for void fraction and interfacial area concentration from 17.32% to 12.3% and 21.26% to 19.6%. The combined RMS error, for both void fraction and interfacial area concentration, is below 15% for most of the experiments used in the comparison, a distinct improvement over the previous version of the model.

7 CFR 29.1169 - Scrap (S Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Scrap (S Group). 29.1169 Section 29.1169 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Standards Grades § 29.1169 Scrap (S Group). A byproduct of stemmed and unstemmed tobacco. Scrap...

7 CFR 29.2441 - Scrap (S Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Scrap (S Group). 29.2441 Section 29.2441 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Standards Grades § 29.2441 Scrap (S Group). A byproduct of unstemmed and stemmed tobacco. Scrap...

Area program in population genetics. Final report, November 1, 1975-August 31, 1982

International Nuclear Information System (INIS)

Chu, E.H.Y.; Gershowitz, H.; Meisler, M.H.; Mohrenweiser, H.W.; Neel, J.V.; Rothman, E.D.; Sing, C.S.

1982-01-01

Research results are summarized for the following task areas: (1) Amerindian mutation rates; (2) pilot study of monitoring populations for the frequency of mutation; (3) interdigitation with the biochemical genetics study of the Radiation Effects Research Foundation (Hiroshima, Japan); (4) intraindividual variation in erythrocyte blood group antigens as indicators of somatic mutation; (5) in vitro studies of somatic cell mutation rates; (6) development of approaches to the study of mutation rates; and (7) statistical problems associated with the study of mutation and selection

7 CFR 29.2438 - Thin Leaf (C Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Thin Leaf (C Group). 29.2438 Section 29.2438... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2438 Thin Leaf (C Group). This group consists of leaves... body than those of the B group, and show little or no ground injury. Choice- and fine-quality tobacco...

7 CFR 29.1163 - Smoking Leaf (H Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Smoking Leaf (H Group). 29.1163 Section 29.1163... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.1163 Smoking Leaf (H Group). This group consists of leaves normally grown at or above the midportion of the stalk. Leaves of the H group show a high degree...

Production and Testing of the VITAMIN-B7 Fine-Group and BUGLE-B7 Broad-Group Coupled Neutron/Gamma Cross-Section Libraries Derived from ENDF/B-VII.0 Nuclear Data

Energy Technology Data Exchange (ETDEWEB)

Risner, J. M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Wiarda, D. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Dunn, M. E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Miller, T. M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Peplow, D. E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Patton, B. W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2011-09-30

New coupled neutron-gamma cross-section libraries have been developed for use in light water reactor (LWR) shielding applications, including pressure vessel dosimetry calculations. The libraries, which were generated using Evaluated Nuclear Data File/B Version VII Release 0 (ENDF/B-VII.0), use the same fine-group and broad-group energy structures as the VITAMIN-B6 and BUGLE-96 libraries. The processing methodology used to generate both libraries is based on the methods used to develop VITAMIN-B6 and BUGLE-96 and is consistent with ANSI/ANS 6.1.2. The ENDF data were first processed into the fine-group pseudo-problem-independent VITAMIN-B7 library and then collapsed into the broad-group BUGLE-B7 library. The VITAMIN-B7 library contains data for 391 nuclides. This represents a significant increase compared to the VITAMIN-B6 library, which contained data for 120 nuclides. The BUGLE-B7 library contains data for the same nuclides as BUGLE-96, and maintains the same numeric IDs for those nuclides. The broad-group data includes nuclides which are infinitely dilute and group collapsed using a concrete weighting spectrum, as well as nuclides which are self-shielded and group collapsed using weighting spectra representative of important regions of LWRs. The verification and validation of the new libraries includes a set of critical benchmark experiments, a set of regression tests that are used to evaluate multigroup crosssection libraries in the SCALE code system, and three pressure vessel dosimetry benchmarks. Results of these tests confirm that the new libraries are appropriate for use in LWR shielding analyses and meet the requirements of Regulatory Guide 1.190.

7 CFR 29.2437 - Heavy Leaf (B Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Heavy Leaf (B Group). 29.2437 Section 29.2437... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2437 Heavy Leaf (B Group). This group consists of leaves..., are heavier in body than those of the X or C groups, and show no ground injury. Choice- and fine...

7 CFR 29.2662 - Heavy Leaf (B Group).

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Heavy Leaf (B Group). 29.2662 Section 29.2662 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... REGULATIONS TOBACCO INSPECTION Standards Grades § 29.2662 Heavy Leaf (B Group). This group consists of leaves...

7 CFR 318.13-5 - Pest-free areas.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Pest-free areas. 318.13-5 Section 318.13-5 Agriculture... and the Territories § 318.13-5 Pest-free areas. Certain fruits or vegetables may be moved interstate provided that the fruits or vegetables originate from an area that is free of a specific pest or pests. In...

7 CFR 319.56-5 - Pest-free areas.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Pest-free areas. 319.56-5 Section 319.56-5 Agriculture..., DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Fruits and Vegetables § 319.56-5 Pest-free areas. As... provided that the fruits or vegetables originate from an area that is free of a specific pest or pests. In...

Molecular detection of spotted fever group Rickettsia in Dermacentor silvarum from a forest area of northeastern China

NARCIS (Netherlands)

W.-C. Cao (Wu-Chun); L. Zhan (Lin); S.J. de Vlas (Sake); B.-H. Wen (Bo-Hai); H. Yang (Honghui); J.H. Richardus (Jan Hendrik); J.D.F. Habbema (Dik)

2008-01-01

textabstractIn total, 676 Dermacentor silvarum Olenev (Acari: Ixodidae) from a forest area of Jilin Province in northeastern China were examined by polymerase chain reaction for the presence of spotted fever group (SFG) Rickettsia. The overall positive rate was 10.7%, with a 95% confidence interval

Two-group interfacial area concentration correlations of two-phase flows in large diameter pipes

International Nuclear Information System (INIS)

Shen, Xiuzhong; Hibiki, Takashi

2015-01-01

The reliable empirical correlations and models are one of the important ways to predict the interfacial area concentration (IAC) in two-phase flows. However, up to now, no correlation or model is available for the prediction of the IAC in the two-phase flows in large diameter pipes. This study collected an IAC experimental database of two-phase flows taken under various flow conditions in large diameter pipes and presented a systematic way to predict the IAC for two-phase flows from bubbly, cap-bubbly to churn flow in large diameter pipes by categorizing bubbles into two groups (group-1: spherical and distorted bubble, group-2: cap bubble). Correlations were developed to predict the group-1 void fraction from the void fraction of all bubble. The IAC contribution from group-1 bubbles was modeled by using the dominant parameters of group-1 bubble void fraction and Reynolds number based on the parameter-dependent analysis of Hibiki and Ishii (2001, 2002) using one-dimensional bubble number density and interfacial area transport equations. A new drift velocity correlation for two-phase flow with large cap bubbles in large diameter pipes was derived in this study. By comparing the newly-derived drift velocity correlation with the existing drift velocity correlation of Kataoka and Ishii (1987) for large diameter pipes and using the characteristics of the representative bubbles among the group 2 bubbles, we developed the model of IAC and bubble size for group 2 cap bubbles. The developed models for estimating the IAC are compared with the entire collected database. A reasonable agreement was obtained with average relative errors of ±28.1%, ±54.4% and ±29.6% for group 1, group 2 and all bubbles respectively. (author)

Site Safety and Health Plan (Phase 3) for the treatability study for in situ vitrification at Seepage Pit 1 in Waste Area Grouping 7, Oak Ridge National Laboratory, Oak Ridge, TN

International Nuclear Information System (INIS)

Spalding, B.P.; Naney, M.T.

1995-06-01

This plan is to be implemented for Phase III ISV operations and post operations sampling. Two previous project phases involving site characterization have been completed and required their own site specific health and safety plans. Project activities will take place at Seepage Pit 1 in Waste Area Grouping 7 at ORNL, Oak Ridge, Tennessee. Purpose of this document is to establish standard health and safety procedures for ORNL project personnel and contractor employees in performance of this work. Site activities shall be performed in accordance with Energy Systems safety and health policies and procedures, DOE orders, Occupational Safety and Health Administration Standards 29 CFR Part 1910 and 1926; applicable United States Environmental Protection Agency requirements; and consensus standards. Where the word ''shall'' is used, the provisions of this plan are mandatory. Specific requirements of regulations and orders have been incorporated into this plan in accordance with applicability. Included from 29 CFR are 1910.120 Hazardous Waste Operations and Emergency Response; 1910.146, Permit Required - Confined Space; 1910.1200, Hazard Communication; DOE Orders requirements of 5480.4, Environmental Protection, Safety and Health Protection Standards; 5480.11, Radiation Protection; and N5480.6, Radiological Control Manual. In addition, guidance and policy will be followed as described in the Environmental Restoration Program Health and Safety Plan. The levels of personal protection and the procedures specified in this plan are based on the best information available from reference documents and site characterization data. Therefore, these recommendations represent the minimum health and safety requirements to be observed by all personnel engaged in this project

Site Safety and Health Plan (Phase 3) for the treatability study for in situ vitrification at Seepage Pit 1 in Waste Area Grouping 7, Oak Ridge National Laboratory, Oak Ridge, TN

Energy Technology Data Exchange (ETDEWEB)

Spalding, B.P.; Naney, M.T.

1995-06-01

This plan is to be implemented for Phase III ISV operations and post operations sampling. Two previous project phases involving site characterization have been completed and required their own site specific health and safety plans. Project activities will take place at Seepage Pit 1 in Waste Area Grouping 7 at ORNL, Oak Ridge, Tennessee. Purpose of this document is to establish standard health and safety procedures for ORNL project personnel and contractor employees in performance of this work. Site activities shall be performed in accordance with Energy Systems safety and health policies and procedures, DOE orders, Occupational Safety and Health Administration Standards 29 CFR Part 1910 and 1926; applicable United States Environmental Protection Agency requirements; and consensus standards. Where the word ``shall`` is used, the provisions of this plan are mandatory. Specific requirements of regulations and orders have been incorporated into this plan in accordance with applicability. Included from 29 CFR are 1910.120 Hazardous Waste Operations and Emergency Response; 1910.146, Permit Required - Confined Space; 1910.1200, Hazard Communication; DOE Orders requirements of 5480.4, Environmental Protection, Safety and Health Protection Standards; 5480.11, Radiation Protection; and N5480.6, Radiological Control Manual. In addition, guidance and policy will be followed as described in the Environmental Restoration Program Health and Safety Plan. The levels of personal protection and the procedures specified in this plan are based on the best information available from reference documents and site characterization data. Therefore, these recommendations represent the minimum health and safety requirements to be observed by all personnel engaged in this project.

Brazilian pediatric research groups, lines of research, and main areas of activity

Directory of Open Access Journals (Sweden)

Priscila H.A. Oliveira

2015-06-01

Full Text Available OBJECTIVES: The Brazilian scientific production in the pediatrics field has been increasing significantly. It is important to identify the distribution and activity of these groups in the country and the main study areas, contributing with data for better resource allocation by institutions. METHODS: An active research was conducted in the National Council of Technological and Scientific Development (Conselho Nacional de Desenvolvimento Científico e Tecnológico [CNPq] website, using as filters the macro area of the research group (Health Sciences, the area (Medicine, and descriptors related to pediatrics. Research lines and main area of pediatric research groups were classified according to the subject predominantly studied by each group. The scientific production of the leader of the pediatric research group between 2011 and 2014 was also analyzed. RESULTS: Most pediatric research groups in Brazil have more than five years of activity and are concentrated in the Southeast and South regions of the country; São Paulo, Rio Grande do Sul, and Minas Gerais are the states with most groups. Of the 132 specific pediatric research groups analyzed, 14.4% have lines of research in multiple areas and 11.4% in child and adolescent health. Among the 585 lines of research of these groups, the most prevalent areas were: oncology, infectious diseases, epidemiology, and gastroenterology. CONCLUSIONS: The pediatric research groups in Brazil have relevant scientific production, including works published in international publications, and are concentrated in regions with higher socioeconomic index. Most groups registered in CNPq started their activity in the last five years (46%, reflecting the recent growth of scientific production in this area.

33 CFR 165.923 - Regulated Navigation Area between mile markers 296.1 and 296.7 of the Chicago Sanitary and Ship...

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Regulated Navigation Area between mile markers 296.1 and 296.7 of the Chicago Sanitary and Ship Canal located near Romeoville, IL. 165.923 Section 165.923 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY REGULATED...

Surveillance of bluetongue virus antibody in goats using a recombinant VP7-based indirect ELISA in the coastal saline area of West Bengal, India

Directory of Open Access Journals (Sweden)

Raj K. Singh

2009-06-01

Full Text Available The authors describe the serological surveillance of bluetongue virus (BTV group-specific antibody in goats of the coastal saline (Sunderban area of West Bengal, India. A recombinant viral protein 7 (rVP7-based indirect enzyme-linked immunosorbent assay (ELISA was used to detect the antibody in sera. The bacterially expressed rVP7 was purified by affinity chromatography. The diagnostic performance of the assay was assessed by comparing it to the commercially available previously validated competitive ELISA. Using the control and 1 202 test sera, the cut-off value, sensitivity and specificity as well as other performance characteristics e.g. the Youden index, efficiency, positive and negative predictive value and prevalence were estimated. Field-collected goat sera (n = 1 202 were tested and a serological prevalence rate of 47% was observed in the study area.

Additional borehole geophysical logging at Waste Area Grouping 1 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1994-07-01

This technical memorandum describes the borehole geophysical logging performed at selected coreholes at Waste Area Grouping 1 between March and November 1991 in support of the remedial investigation. The primary objectives of the borehole geophysical logging program were to (1) identify fractured bedrock zones and identify those fractured bedrock zones participating in active groundwater flow, (2) correlate the fractured intervals with the regional stratigraphy described, and (3) further characterize local bedrock geology and hydrogeology and gain insight about the bedrock aquifer flow system. A secondary objective was to provide stratigraphic correlations with existing logs for coreholes CH001 through CH005. Fractured bedrock zones and active or open fractures were identified in all coreholes logged. The fracture identification and analysis process was intended to distinguish between open or active fractures participating in active groundwater flow and closed or inactive fractures that are partially or completely filled (such as with calcite mineralization) and do not support groundwater circulation. Most of the fractures identified are bedding plane. Fracture occurrence varies with the different units of the Chickamauga Group; the greatest density of fractures and active fractures occurs in the upper 150 ft of stratum cored. Fractures actively contributing to groundwater flow were also identified, and direction of fluid movement within fractures was identified for those coreholes with flowmeter data

7 CFR 1030.2 - Upper Midwest marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Upper Midwest marketing area. 1030.2 Section 1030.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE UPPER MIDWEST MARKETING AREA Order...

7 CFR 1124.2 - Pacific Northwest marketing area.

Science.gov (United States)

2010-01-01

... 7 Agriculture 9 2010-01-01 2009-01-01 true Pacific Northwest marketing area. 1124.2 Section 1124.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE PACIFIC NORTHWEST MARKETING AREA Order...

Sampling and analysis plan for the site characterization of the waste area Grouping 1 groundwater operable unit at Oak Ridge National Laboratory

International Nuclear Information System (INIS)

1994-11-01

Waste Area Grouping (WAG) 1 at Oak Ridge National Laboratory (ORNL) includes all of the former ORNL radioisotope research, production, and maintenance facilities; former waste management areas; and some former administrative buildings. Site operations have contaminated groundwater, principally with radiological contamination. An extensive network of underground pipelines and utilities have contributed to the dispersal of contaminants to a known extent. In addition, karst geology, numerous spills, and pipeline leaks, together with the long and varied history of activities at specific facilities at ORNL, complicate contaminant migration-pathway analysis and source identification. To evaluate the extent of contamination, site characterization activity will include semiannual and annual groundwater sampling, as well as monthly water level measurements (both manual and continuous) at WAG 1. This sampling and analysis plan provides the methods and procedures to conduct site characterization for the Phase 1 Remedial Investigation of the WAG 1 Groundwater Operable Unit

Waste area Grouping 2 Phase I remedial investigation: Sediment and Cesium-137 transport modeling report

International Nuclear Information System (INIS)

Clapp, R.B.; Bao, Y.S.; Moore, T.D.; Brenkert, A.L.; Purucker, S.T.; Reece, D.K.; Burgoa, B.B.

1996-06-01

This report is one of five reports issued in 1996 that provide follow-up information to the Phase I Remedial Investigation (RI) Report for Waste Area Grouping (WAG) 2 at Oak Ridge National Laboratory (ORNL). The five reports address areas of concern that may present immediate risk to public health at the Clinch River and ecological risk within WAG 2 at ORNL. A sixth report, on groundwater, in the series documenting WAG 2 RI Phase I results were part of project activities conducted in FY 1996. The five reports that complete activities conducted as part of Phase I of the Remedial Investigation (RI) for WAG 2 are as follows: (1) Waste Area Grouping 2, Phase I Task Data Report: Seep Data Assessment, (2) Waste Area Grouping 2, Phase I Task Data Report: Tributaries Data Assessment, (3) Waste Area Grouping 2, Phase I Task Data Report: Ecological Risk Assessment, (4) Waste Area Grouping 2, Phase I Task Data Report: Human Health Risk Assessment, (5) Waste Area Grouping 2, Phase I Task Data Report: Sediment and 137 Cs Transport Modeling In December 1990, the Remedial Investigation Plan for Waste Area Grouping 2 at Oak Ridge National Laboratory was issued (ORNL 1990). The WAG 2 RI Plan was structured with a short-term component to be conducted while upgradient WAGs are investigated and remediated, and a long-term component that will complete the RI process for WAG 2 following remediation of upgradient WAGs. RI activities for the short-term component were initiated with the approval of the Environmental Protection Agency, Region IV (EPA), and the Tennessee Department of Environment and Conservation (TDEC). This report presents the results of an investigation of the risk associated with possible future releases of 137 Cs due to an extreme flood. The results are based on field measurements made during storms and computer model simulations

Diffusion and export dynamics of "1"3"7Cs deposited on the forested area in Fukushima after the nuclear power plant accident in March 2011. Preliminary results

International Nuclear Information System (INIS)

Ohte, Nobuhito; Iseda, Kohei; Tanoi, Keitaro; Murakami, Masashi; Suzuki, Takahiro; Ishii, Nobuyoshi

2013-01-01

A massive amount of radioactive substances, including cesium-137 ("1"3"7Cs), emitted from the disabled nuclear power plant, has been deposited on the forested areas in the northeastern region of Honshu Island, Japan after the Fukushima Daiichi nuclear power plant accident. Forests in these regions are particularly important, not only for the forest products industry but also for source areas of drinking water and for residential environments. To clarify the mechanisms of diffusion and export of "1"3"7Cs deposited on the forested ecosystem, we initiated intensive field observations in a small catchment that included forest and farmlands. Specifically, we were interested in the Kami-Oguni River catchment that is located in the northern part of Fukushima Prefecture. The following expected major pathways of "1"3"7Cs export and diffusion were investigated: 1) transportation of dissolved and particulate or colloidal forms via hydrological processes within a forested catchment and export dynamics through the stream, and 2) diffusion through the food web in terrestrial and aquatic ecosystems of forests. Preliminary findings indicated the following: 1) Most of the "1"3"7Cs was discharged as suspended matter. High water flow generated by storm acted to accelerate the transportation of "1"3"7Cs from the forested catchments. Thus, the estimation of "1"3"7Cs export requires precise evaluation of the high flow acceleration during storm events; 2) Because litter and its detritus may form the biggest pool of "1"3"7Cs in the forested ecosystem, "1"3"7Cs diffusion occurs more rapidly through the detritus food chain than the grazing food chain. Most predators have already ingested "1"3"7Cs, particularly in aquatic environments. An urgent question that needs to be addressed is when and how "1"3"7Cs diffuses through grazing food chains and how rapidly this process occurs. To elucidate or to be able to predict these phenomena, the mechanisms of "1"3"7Cs release from litter and soil

Fragrance material review on 1-spiro[4.5]dec-7-en-7-yl-4-pent-1-one.

Science.gov (United States)

Scognamiglio, J; Letizia, C S; Api, A M

2013-12-01

A toxicologic and dermatologic review of 1-spiro[4.5]dec-7-en-7-yl-4-pent-1-one when used as a fragrance ingredient is presented. 1-Spiro[4.5]dec-7-en-7-yl-4-pent-1-one is a member of the fragrance structural group Alkyl Cyclic Ketones. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all published and unpublished toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 1-spiro[4.5]dec-7-en-7-yl-4-pent-1-one were evaluated then summarized and includes acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, phototoxicity, photoallergy, repeated dose, and genotoxicity data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (2013) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances. Copyright © 2013 Elsevier Ltd. All rights reserved.

Readiness review plan for the in situ vitrification demonstration of Seepage Pit 1 in Waste Area Grouping 7

International Nuclear Information System (INIS)

1995-05-01

A treatability study is planned that encompasses the application of in situ vitrification (ISV) to at least two segments of the Oak Ridge National Laboratory Seepage Pit I during the third quarter of fiscal year 1995. Before the treatability study can be initiated, the proposed activity must be subjected to an Operational Readiness Review (ORR). ORR is a structured methodology of determining readiness to proceed as outlined in Martin Marietta Energy Systems, Inc. (Energy Systems), Environmental Restoration Waste Management Procedure ER/C-P1610, which provides Energy Systems organizations assurance that the work to be performed is consistent with management's expectations and that the subject activity is ready to proceed safely. The readiness review plan provides details of the review plan overview and the scope of work to be performed. The plan also identifies individuals and position responsibilities for implementing the activity. The management appointed Readiness Review Board (RRB) has been identified. A Field Readiness Review Team (FRT), a management appointed multidisciplinary group, has been established (1) to evaluate the ISV treatability study, (2) to identify and assemble supporting objective evidences of the readiness to proceed, and (3) to assist the team leader in presenting the evidences to the RRB. A major component of RRB is the formulation of readiness review criteria months before the operation. A comprehensive readiness review tree (a positive logic tree) is included, which identifies the activities required for the development of the readiness criteria. The readiness review tree serves as a tool to prevent the omission of an item that could affect system performance. All deficiencies identified in the review will be determined as prestart findings and must be resolved before the project is permitted to proceed. The final approval of the readiness to proceed will be the decision of RRB

Data management implementation plan for the site characterization of the Waste Area Grouping 1 Groundwater Operable Unit at Oak Ridge National Laboratory

International Nuclear Information System (INIS)

Ball, T.S.; Nickle, E.B.

1994-10-01

The Waste Area Grouping (WAG) 1 Groundwater Operable Unit (OU) at Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee, is undergoing a site characterization. This project is not mandated by the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA); therefore, no formalized meetings for data quality objective (DQO) development were held. Internally, DQOs were generated by the project team based on the end uses of the data to be collected. The 150-acre WAG 1 is contained within the ORNL security area. It includes all of the former ORNL radioisotope research, production, and maintenance facilities; former waste management areas; and some former administrative facilities. The goal of the WAG 1 Groundwater Site Characterization is to provide the necessary data on the nature and extent of groundwater contamination with an acceptable level of uncertainty to support the selection of remedial alternatives and to identify additional data needs for future actions. Primary objectives for the site characterization are: (1) To identify and characterize contaminant migration pathways based on the collection of groundwater data; (2) to identify sources of groundwater contamination and evaluate remedial actions which could be implemented to control or eliminate these sources; and (3) To conduct groundwater monitoring in support of other OUs in WAG 1 and the ORNL Groundwater OU

Modeling strategy of the source and sink terms in the two-group interfacial area transport equation

International Nuclear Information System (INIS)

Ishii, Mamoru; Sun Xiaodong; Kim, Seungjin

2003-01-01

This paper presents the general strategy for modeling the source and sink terms in the two-group interfacial area transport equation. The two-group transport equation is applicable in bubbly, cap bubbly, slug, and churn-turbulent flow regimes to predict the change of the interfacial area concentration. This dynamic approach has an advantage of flow regime-independence over the conventional empirical correlation approach for the interfacial area concentration in the applications with the two-fluid model. In the two-group interfacial area transport equation, bubbles are categorized into two groups: spherical/distorted bubbles as Group 1 and cap/slug/churn-turbulent bubbles as Group 2. Thus, two sets of equations are used to describe the generation and destruction rates of bubble number density, void fraction, and interfacial area concentration for the two groups of bubbles due to bubble expansion and compression, coalescence and disintegration, and phase change. Based upon a detailed literature review of the research on the bubble interactions, five major bubble interaction mechanisms are identified for the gas-liquid two-phase flow of interest. A systematic integral approach, in which the significant variations of bubble volume and shape are accounted for, is suggested for the modeling of two-group bubble interactions. To obtain analytical forms for the various bubble interactions, a simplification is made for the bubble number density distribution function

Class 1 Areas

Data.gov (United States)

U.S. Environmental Protection Agency — A "Class 1" area is a geographic area recognized by the EPA as being of the highest environmental quality and requiring maximum protection. Class I areas are areas...

Organic petrography:An approach for identification of maceral groups in Gheshlagh coal area, Eastern Alborz

Directory of Open Access Journals (Sweden)

Tahereh Rabani

2016-07-01

, collotelinite, and corpogelinite macerals. Collodetrinite maceral (20 to 65.6 vol.% is the most abundant maceral in the vitrinite group and is associated with inertodetrinite and microspornite macerals. Callotelinite (8.4 to 46.7 wt% occurs as a structureless, homogeneous mass in the Gheshlagh coal seams. The inertinite group (4.9 to 23.3 vol% includes fusinite, semifusinite, macrinite, secretinite, funginite and inertodetrinite macerals. Fusinite (1.7 to12.7 vol.% is present in all coal seams in the Gheshlagh area. Cell cavities of fusinite are filled mostly by corpogelinite and clay minerals. Semifusinite occurs in appreciable concentrations (2.1to 14.3vol.% and Cell lumens of this maceral are filled with mineral matter, pyrite and clay. The liptinite group (nil to 3.5 vol% includes sporinite, cutinite and resinite macerals. Sporinite is the dominant maceral in the liptinite group (nil to 2.3 vol.% and occurs as elongated thread-like or spindle-shaped bodies and occurs as microspores and megaspores. Resinite (nil to 0.1 vol.% occurs as round to oval bodies and as fillings of the cell cavities of fusinite, semifusinite and funginite. The mineral matter content of most of the Gheshlagh coal seams varies between 3.1 and 24.9 vol.%. Mineral matter occurs in primary ground mass or secondary cavity filling form and includes clay minerals, carbonate and sulphide. Conclusion Based on organic petrographic studies carried out on four active coal mines in the Gheshlagh area, the presence of three maceral groups were determined. The vitrinite group (66.2 to 87.2 vol% is the dominant maceral group, and callodetrinite maceral (20 to 65.6 vol% is also abundant. The inertinite group contenthas a range of 4.9 to 23.3 vol% while the fusinite and semifusinite macerals are the most abundant of this group. The lowest volume percentage of macerals belongs to the liptinite group (0 to 3.5 vol% with 2.3 vol% espornitebeing the most abundant Maceral of this group. The presence of espornite maceral at

7 CFR 250.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 250.1 Section 250.1... AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION DONATION OF FOODS FOR USE IN THE UNITED STATES, ITS TERRITORIES AND POSSESSIONS AND AREAS UNDER ITS JURISDICTION General § 250.1 General purpose and...

[A survey of HIV, HBV and HCV infections in children aged 1-13 years in Yi ethnic area, Sichuan province].

Science.gov (United States)

Yang, Y; Zhou, Y B; Cheng, W T; Pan, X; Song, X X; Jiang, Q W

2017-09-10

Objective: To investigate the prevalence of HIV, HBV and HCV infections in children aged 1-13 years in Yi ethnic area in Sichuan province. Methods: A cross-sectional study was conducted in the form of field survey in four townships selected from Yi ethnic area of Sichuan during 2014-2015. Participants were children aged 1-13 years by sample size of 900 and were screened for HIV antibody, HBV surface antigen and HCV antibody, and laboratory comfirmation was conducted. The area, age, gender and ethnic group specific infection rates were compared by using Fisher's exact test, and multiple comparisons were corrected by using Bonferroni correction. Results: A total of 677 children aged 1-13 years were surveyed. The infection rates of HIV, HBV and HCV were 1.03 % (7/677, 95 %CI : 0.42 % -1.12 % ), 6.65 % (45/677, 95 %CI : 4.89 % -8.79 % ) and 0.15 % (1/677, 95 %CI : 0 % -0.82 % ), respectively. The infection rates of HIV differed among townships ( P =0.000), the infection rate was higher in township D than in township B, the difference was significant ( P HBV and HCV infections were not significant among different townships, age, gender and ethnic groups. The difference in HBV viral load between age group 5-9 years and age groups 10-13 years was not significant ( U =115.000, P =0.967). Conclusions: The burden of HIV and HBV infections in children aged 1-13 years was heavy in rural area of Yi ethnic area in Sichuan. Therefore, it is necessary to take effective measures to block the vertical transmission of HIV and HBV as well as to increase the coverage of HBV vaccination.

An epidemiological study of diabetes mellitus amongst high risk age group population in urban and Rural areas of kanpur

Directory of Open Access Journals (Sweden)

Nadeem Ahmad

2003-12-01

Full Text Available Research Question : - What is the magnitude of Diabetes mellitus in the urban and rural areas of Kanpur.Objectives:To study the prevalence of diabetes mellitus amongst high risk age group population in urban and rural areas of Kanpur.To compare the magnitude of problem of diabetes mellitus between urban and rural areas of Kanpur.To study the possible associates and socio-demographic variables related to diabetes mellitus.Study Design : Cross sectional study.Setting : The study was performed on three thousand population each in urban and rural areas of Kanpur.Participants : High risk age group population i.e. 45 years and above.Study variables : Age, Sex. impaired glucose tolerance. Body mass index, Education, Working status. Social class, family history of diabetes.Statistical analysis : Chi-square lest, percentagesResults From a total of 676 persons of high risk age group i.e. 45 years and above, the overall prevalence of diabetes mellitus in the study areas was observed lobe 7. l%with 9.94% in urban and 3.61% in rural areas, the maximum percetage of diabetes cases (41.66% was in the age group of 56-60 years. Higher prevalence of diabetes was observed in the obese (56.25% and sedentary (87.5% persons. The family history' of diabetes mellitus was present in (35.41% of diabetes mellitus cases.

7 CFR 225.1 - General purpose and scope.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false General purpose and scope. 225.1 Section 225.1... AGRICULTURE CHILD NUTRITION PROGRAMS SUMMER FOOD SERVICE PROGRAM General § 225.1 General purpose and scope... primary purpose of the Program is to provide food service to children from needy areas during periods when...

7 CFR 3400.11 - Composition of peer review groups.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Composition of peer review groups. 3400.11 Section..., EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE SPECIAL RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3400.11 Composition of peer review groups. (a) Peer review group...

7 CFR 3415.11 - Composition of peer review groups.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Composition of peer review groups. 3415.11 Section... PROGRAM Scientific Peer Review of Research Grant Applications § 3415.11 Composition of peer review groups. (a) Peer review group members and ad hoc reviewers will be selected based upon their training and...

7 CFR 3411.11 - Composition of peer review groups.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Composition of peer review groups. 3411.11 Section... PROGRAM Scientific Peer Review of Research Grant Applications § 3411.11 Composition of peer review groups. (a) Peer review group members and ad hoc reviewers will be selected based upon their training and...

7 CFR 3401.13 - Composition of peer review groups.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Composition of peer review groups. 3401.13 Section... Peer Review of Research Applications for Funding § 3401.13 Composition of peer review groups. Peer review group members will be selected based upon their training or experience in relevant scientific or...

7 CFR 1780.11 - Service area requirements.

Science.gov (United States)

2010-01-01

..., maintenance, debt service, and reserve requirements. Such guarantees from developers will meet the... 7 Agriculture 12 2010-01-01 2010-01-01 false Service area requirements. 1780.11 Section 1780.11... AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.11 Service...

Group distribution characteristics of lachrymal duct obstruction diseases in major Li Miao minority areas of Hainan province

Directory of Open Access Journals (Sweden)

Hua-Li Zhou

2014-07-01

Full Text Available AIM: To determine the group distribution characteristics of lachrymal duct obstruction diseases in major Li Miao minority areas of Hainan province. METHODS: Totally 5 353 residents were selected and researched by randomized cluster sampling in the major Li Miao minority areas of Hainan province. Ocular examination and lachrymal duct flushing were carried out, and questionnaire survey on lachrymal duct obstruction was conducted. The ratio of lachrymal duct obstruction diseases and group distribution characteristics were analyzed based on above research. RESULTS: The prevalence ratios of lachrymal duct obstruction was 4.47% in major Li Miao minority areas of Hainan province, with 2.62% in urban area, and 5.93% in rural area respectively. Prevalence ratios of men and women group were 1.69% and 6.39% correspondingly. Difference between the two groups was statistically significant(χ2=67.2821, P=0.0000. The highest prevalence ratio was 40-69 year-old group, second one was 70-79 year-old group, especially for women in these groups. The prevalence ratios of Ledong, Lingshui, Baisha and Changjiang county were higher than those of Baoting, Qiongzhong county and Wuzhishan city. No significant difference was found between both eyes. CONCLUSION: In major Li Miao minority areas of Hainan province, lachrymal duct obstruction mainly occurs in 40-79 year-old patients, with specially higher ratio of women. Statistically, significant difference of the prevalence ratio between urban and rural areas exists. The higher prevalence ratio is attributed to age, gender, geographical location, climate condition, health environment and so on. The prevalence ratio is higher in the dry and windy areas than in the humid and less windy areas.

Objective image analysis of the meibomian gland area.

Science.gov (United States)

Arita, Reiko; Suehiro, Jun; Haraguchi, Tsuyoshi; Shirakawa, Rika; Tokoro, Hideaki; Amano, Shiro

2014-06-01

To evaluate objectively the meibomian gland area using newly developed software for non-invasive meibography. Eighty eyelids of 42 patients without meibomian gland loss (meiboscore=0), 105 eyelids of 57 patients with loss of less than one-third total meibomian gland area (meiboscore=1), 13 eyelids of 11 patients with between one-third and two-thirds loss of meibomian gland area (meiboscore=2) and 20 eyelids of 14 patients with two-thirds loss of meibomian gland area (meiboscore=3) were studied. Lid borders were automatically determined. The software evaluated the distribution of the luminance and, by enhancing the contrast and reducing image noise, the meibomian gland area was automatically discriminated. The software calculated the ratio of the total meibomian gland area relative to the total analysis area in all subjects. Repeatability of the software was also evaluated. The mean ratio of the meibomian gland area to the total analysis area in the upper/lower eyelids was 51.9±5.7%/54.7±5.4% in subjects with a meiboscore of 0, 47.7±6.0%/51.5±5.4% in those with a meiboscore of 1, 32.0±4.4%/37.2±3.5% in those with a meiboscore of 2 and 16.7±6.4%/19.5±5.8% in subjects with a meiboscore of 3. The meibomian gland area was objectively evaluated using the developed software. This system could be useful for objectively evaluating the effect of treatment on meibomian gland dysfunction. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

7 CFR 905.16 - Regulation Area II.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Regulation Area II. 905.16 Section 905.16 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... the St. Johns River; thence along the main channel of the St. Johns River and through Lake Harney...

Summary of Synoptic Meteorological Observations (SSMO). Australian Coastal Marine Areas. Volume 1. Area 1 - Princess Charlotte Bay. Area 2 - Cairns. Area 3 - Cumberland Islands. Area 4 - Rockhampton. Area 5 - Brisbane. Area 6 - Coffs Harbour. Area 7 - Sydney. Area 8 - Cape Howe NE

Science.gov (United States)

1977-09-01

Weather Service Detachment Asheville, N. C. 8. CONTRACT OR GRANT NUMBERf«) 9. PERFORMING ORGANIZATION NAME AND ADDRESS National Climatic Center...Australian East Coast, Princess Charlotte Bay, Cairns, Cumberland Islands, Rockhampton, Brisbane, Coffs Harbour, Sydney and Cape Howe NE. ^ 20...OVER-ALL) 1»S«-1973 AREA 0006 COFFS HARBOUR 30.3S 193.36 fERCENT FR60UENCY OF MSATHER OCCURRENCE BY NINO OIRECTION

Region 7 Significant Ecological Resource Areas (ECO_RES.SIG_REGIONS)

Data.gov (United States)

U.S. Environmental Protection Agency — SIG_REGIONS is a boundary layer that displays Region 7's Significant Ecological Resource Areas. This layer represents large areas within which different ecosystem...

Action memorandum for the Waste Area Grouping 1 Tank WC-14 removal action at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1994-11-01

This action memorandum documents approval for a Comprehensive Environmental Response, Compensation, and Liability Act of 1980, as amended (CERCLA), time-critical action. The action will remove radiologically contaminated water from Tank WC-14. The water contains a polychlorinated biphenyl (PCB) at a level below regulatory concern. Tank WC-14 is located in the Waste Area Grouping (WAG) 1 WC-10 Tank Farm at the Oak Ridge National Laboratory (ORNL), Oak Ridge, Tennessee. Contaminated sludge remaining in the tank after removal of the liquid will be the subject of a future action

Assessing emergency situations and their aftermath in urban areas: The EMRAS II Urban Areas Working Group

DEFF Research Database (Denmark)

Thiessen, K.M.; Andersson, Kasper Grann; Berkovskyy, V.

2011-01-01

The Urban Areas Working Group is part of the International Atomic Energy Agency’s EMRAS II (Environmental Modelling for Radiation Safety) Programme. The goal of this Working Group is to test and improve the capabilities of models used in assessment of radioactive contamination in urban settings...

The classification of the finite simple groups, number 7 part III, chapters 7-11 the generic case, stages 3b and 4a

CERN Document Server

Gorenstein, Daniel; Solomon, Ronald

2018-01-01

The classification of finite simple groups is a landmark result of modern mathematics. The multipart series of monographs which is being published by the AMS (Volume 40.1-40.7 and future volumes) represents the culmination of a century-long project involving the efforts of scores of mathematicians published in hundreds of journal articles, books, and doctoral theses, totaling an estimated 15,000 pages. This part 7 of the series is the middle of a trilogy (Volume 40.5, Volume 40.7, and forthcoming Volume 40.8) treating the Generic Case, i.e., the identification of the alternating groups of degree at least 13 and most of the finite simple groups of Lie type and Lie rank at least 4. Moreover, Volumes 40.4-40.8 of this series will provide a complete treatment of the simple groups of odd type, i.e., the alternating groups (with two exceptions) and the groups of Lie type defined over a finite field of odd order, as well as some of the sporadic simple groups. In particular, this volume completes the construction, be...

Surface radiological investigation of Trench 5 in Waste Area Grouping 7 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Goff, D.D.

1991-08-01

A surface radiological investigation of areas encompassing Trench 5 on the Oak Ridge Reservation (ORR) was conducted from May 1990 through November 1990. This survey was led by the author, assisted by various members of the Measurement Applications and Development (MAD) group of the Health and Safety Research Division (HASRD) of Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee. The purpose of the investigation was to determine the presence, nature, and extent of surface radiological contamination at Trench 5, the Homogeneous Reactor Experiment fuel wells, and surrounding areas. Based on the data obtained in the field, interim corrective measures were recommended to limit human exposure to radioactivity and to minimize insult to the environment. It should be stressed that this project was not intended to be a complete site characterization but rather to be a preliminary investigation into the potential contamination problem that might exist as a result of past operations at Trench 5

78 FR 72028 - Special Regulations, Areas of the National Park System, Curecanti National Recreation Area...

Science.gov (United States)

2013-12-02

...-substantive edits. The final rule revises the section heading for Sec. 7.51 from ``Curecanti Recreation Area... paragraph 7.51(e) to designate three groups of routes and areas where motor vehicles may be used off park...) and (f). The revisions and additions read as follows: Sec. 7.51 Curecanti National Recreation Area...

7α-alkylation and 7,7-bis-alkylation of 20-hydroxyecdysone with propargyl bromide in a lithium-ammonia solution and catalytic reductive spirocyclization of 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ(8(14))-20-hydroxyecdysone.

Science.gov (United States)

Galyautdinov, Ilgiz V; Khairullina, Zarema R; Sametov, Valery P; Muslimov, Zabir S; Khalilov, Leonard M; Odinokov, Victor N

2016-03-01

7α-Alkylation and 7,7-bis-alkylation of 20-hydroxyecdysone with propargyl bromide in a lithium-ammonia solution resulted in the formation of 7α-(2-propyn-1-yl)- and 7,7-bis(2-propyn-1-yl)-14-deoxy-Δ(8(14))-20-hydroxyecdysone in 92% and 75% yield respectively. Upon catalytic hydrogenation (10% Pd-C) of 7,7-bis(2-propyn-1-yl) derivative spirocyclization occurs by geminal 2-propyn-1-yl groups. Copyright © 2016 Elsevier Inc. All rights reserved.

NCRP Program Area Committee 7: Radiation Education, Risk Communication, Outreach, and Policy.

Science.gov (United States)

Becker, S M; Locke, P A

2016-02-01

Recognizing the central importance of effective communication, education, and policy across all of the domains of radiation safety and radiation protection, the National Council on Radiation Protection and Measurements (NCRP) established a new committee in 2013. Program Area Committee 7 (PAC 7) was created to develop projects and provide guidance on "Radiation Education, Risk Communication, Outreach, and Policy." After identifying individuals with relevant expertise who were willing to serve, the Committee held its inaugural meeting in 2014. In 2015, the Committee increased its membership and began carrying out an expanded program of activities. One area of activity has involved providing input and feedback on risk communication issues to NCRP and other agencies. Another area of work has involved liaising with other NCRP committees (e.g., Council Committee 1 and PAC 3) to help incorporate psychosocial and risk communication issues into projects. Future efforts of NCRP's newest PAC are expected to include the development of authoritative reports and commentaries dealing with critical issues and challenges in radiation risk communication, education, and policy.

7 CFR 3401.12 - Establishment and operation of peer review groups.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishment and operation of peer review groups... GRANTS PROGRAM Scientific Peer Review of Research Applications for Funding § 3401.12 Establishment and operation of peer review groups. Subject to § 3401.7, the Administrator will adopt procedures for the...

One-group interfacial area transport in vertical air-water bubbly flow

International Nuclear Information System (INIS)

Wu, Q.; Kim, S.; Ishii, M.; Beus, S.G.

1997-01-01

In the two-fluid model for two-phase flows, interfacial area concentration is one of the most important closure relations that should be obtained from careful mechanistic modeling. The objective of this study is to develop a one-group interfacial area transport equation together with the modeling of the source and sink terms due to bubble breakage and coalescence. For bubble coalescence, two mechanisms are considered to be dominant in vertical two-phase bubbly flow. These are the random collisions between bubbles due to turbulence in the flow field, and the wake entrainment process due to the relative motion of the bubbles in the wake region of a seeding bubble. For bubble breakup, the impact of turbulent eddies is considered. These phenomena are modeled individually, resulting in a one-group interfacial area concentration transport equation with certain parameters to be determined from experimental data. Compared to the measured axial distribution of the interfacial area concentration under various flow conditions, these parameters are obtained for the reduced one-group, one-dimensional transport equation. The results indicate that the proposed models for bubble breakup and coalescence are appropriate

(2,7-Dimethoxynaphthalen-1-yl(phenylmethanone

Directory of Open Access Journals (Sweden)

Noriyuki Yonezawa

2010-10-01

Full Text Available The asymmetric unit of the title compound, C19H16O3, contains three independent conformers. Each of the three conformers has essentially the same feature of non-coplanar aromatic rings whereby the aroyl group at the 1-position of the naphthalene ring is twisted in a perpendicular manner to the naphthalene ring. The dihedral angles between the benzene ring planes and the naphthalene ring systems are 75.34 (7, 86.47 (7 and 76.55 (6° in the three conformers. The crystal structure is stabilized by intermolecular C—H...O hydrogen bonds.

Summary of the Nevada Applied Ecology Group and correlative programs. Version 1

Energy Technology Data Exchange (ETDEWEB)

Friesen, H.N. [Raytheon Services Nevada, Las Vegas, NV (United States)

1992-10-01

This summary document presents results in a broad context; it is not limited to findings of the Nevada Applied Ecology Group. This book is organized to present the findings of the Nevada Applied Ecology Group and correlative programs in accordance with the originally stated objectives of the Nevada Applied Ecology Group. This plan, in essence, traces plutonium from its injection into the environment to movement in the ecosystem to development of cleanup techniques. Information on other radionuclides was also obtained and will be presented briefly. Chapter 1 presents a brief description of the ecological setting of the Test Range Complex. The results of investigations for plutonium distribution are presented in Chapter 2 for the area surrounding the Test Range Complex and in Chapter 3 for on-site locations. Chapters 4 and 5 present the results of investigations concerned with concentrations and movement, respectively, of plutonium in the ecosystem of the Test Range Complex, and Chapter 6 summarizes the potential hazard from this plutonium. Development of techniques for cleanup and treatment is presented in Chapter 7, and the inventory of radionuclides other than plutonium is presented briefly in Chapter 8.

7 CFR 27.11 - Area Director, Marketing Services Office; responsibility.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Area Director, Marketing Services Office... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY... Regulations Administration § 27.11 Area Director, Marketing Services Office; responsibility. Subject to this...

Peripouch Fat Area Measured on MRI Image and Its Association With Adverse Pouch Outcomes.

Science.gov (United States)

Gao, Xian Hua; Chouhan, Hanumant; Liu, Gang Lei; Lan, Nan; Remer, Erick; Stocchi, Luca; Ashburn, Jean; Hull, Tracy L; Shen, Bo

2018-03-19

There are no published studies on the impact of peripouch fat on pouch outcomes in inflammatory bowel disease (IBD) patients. Patients with pelvic MRI-DIXON scans from our prospectively maintained Pouch Database between 2002 and 2016 were evaluated. Peripouch fat area was measured on MRI-DIXON-F images at the middle height level of the pouch (area M) and the highest level of the pouch (area H). Of all 1863 patients in the database, 197 eligible patients were included in this study. The median of area M was 52.4 cm2, so the 197 patients were classified into 2 groups: group 1 (Area-M Area-M ≥52.4 cm2). Compared with group 1, group 2 was found to have thicker perianal fat, more Caucasian and more males. Group 2 also had a higher Area-H, more weight, height, and body mass index, along with greater age at IBD diagnosis, age at pouch construction and pouch age, and a higher frequency of total pouch complication (86.7% versus 66.7%, P = 0.001), chronic pouch complication (68.4% versus 51.5%, P = 0.016), and chronic antibiotic-refractory pouchitis (16.3% versus 7.1%, P = 0.043). Multivariate logistic analysis showed that Area-M was an independent risk factor for chronic antibiotic-refractory pouchitis (odds ratio [OR]: 1.025; 95% confidence interval [CI]: 1.007-1.042, P = 0.005). The 22 patients with 2 or more pelvic MRI-DIXON scans were further classified into 2 groups by the change from the initial to latest MRI-DIXON scans. Patients with Area-M increase ≥10% and Area-M/height increase ≥10% were found to have shorter pouch survivals than those with increase <10%. A new method was established for measuring peripouch fat using pelvic MRI-DIXON-F image. Our study suggests that accumulation of peripouch fat may be associated with poor outcomes in selected IBD patients suspected of inflammatory or mechanical disorders of the pouch. Whether this association is causal warrants further investigation.

7 CFR 948.50 - Area committees.

Science.gov (United States)

2010-01-01

...' cooperative marketing associations. (c) Area No. 3: Five Producers and four handlers selected as follows... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... forth in this section or as reestablished by § 948.53. (a) Area No. 1 (Western Slope): Four producers...

Synthesis of the water soluble ligands dmPTA and dmoPTA and the complex [RuClCp(HdmoPTA)(PPh(3))](OSO(2)CF(3)) (dmPTA = N,N'-Dimethyl-1,3,5-triaza-7-phosphaadamantane, dmoPTA = 3,7-Dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane, HdmoPTA = 3,7-H-3,7-Dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane).

Science.gov (United States)

Mena-Cruz, Adrian; Lorenzo-Luis, Pablo; Romerosa, Antonio; Saoud, Mustapha; Serrano-Ruiz, Manuel

2007-07-23

The new water-soluble ligand dmPTA(OSO(2)CF(3))(2) (1) (dmPTA = N,N'-dimethyl-1,3,5-triaza-7-phosphaadamantane) has been synthesized by reaction of PTA with MeOSO(2)CF(3) in acetone (PTA = 1,3,5-triaza-7-phosphatricycle[3.3.1.1(3,7)]decane). The reaction of 1 with KOH gave rise to the new water-soluble ligand dmoPTA (3) (dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane) by elimination of the -CH(2)- group located between both NCH(3) units. Compound dmPTA(BF(4))(2) (2) and complex [RuClCp(HdmoPTA)(PPh(3))](OSO(2)CF(3)) (4) have also been synthesized, while compounds HdmoPTA(BF(4)) (3a) and [RuClCp(dmPTA)(PPh(3))](OSO(2)CF(3)) (5) were characterized but not isolated. The new ligands and the complex have been fully characterized by NMR, IR, elemental analysis, and X-ray crystal structure determination (ligand 1 and complex 4). The synthetic processes for 3 and 4 were studied.

7 CFR 319.8-11 - From approved areas of Mexico.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false From approved areas of Mexico. 319.8-11 Section 319.8... Conditions for the Entry of Cotton and Covers from Mexico § 319.8-11 From approved areas of Mexico. (a) Entry... in, and which were produced and handled only in approved areas of Mexico 5 may be authorized through...

Connections of the medial posterior parietal cortex (area 7m) in the monkey.

Science.gov (United States)

Leichnetz, G R

2001-06-01

The afferent and efferent cortical and subcortical connections of the medial posterior parietal cortex (area 7m) were studied in cebus (Cebus apella) and macaque (Macaca fascicularis) monkeys using the retrograde and anterograde capabilities of the horseradish peroxidase (HRP) technique. The principal intraparietal corticocortical connections of area 7m in both cebus and macaque cases were with the ipsilateral medial bank of the intraparietal sulcus (MIP) and adjacent superior parietal lobule (area 5), inferior parietal lobule (area 7a), lateral bank of the IPS (area 7ip), caudal parietal operculum (PGop), dorsal bank of the caudal superior temporal sulcus (visual area MST), and medial prestriate cortex (including visual area PO and caudal medial lobule). Its principal frontal corticocortical connections were with the prefrontal cortex in the shoulder above the principal sulcus and the cortex in the shoulder above the superior ramus of the arcuate sulcus (SAS), the area purported to contain the smooth eye movement-related frontal eye field (FEFsem) in the cebus monkey by other investigators. There were moderate connections with the cortex in the rostral bank of the arcuate sulcus (purported to contain the saccade-related frontal eye field; FEFsac), supplementary eye field (SEF), and rostral dorsal premotor area (PMDr). Area 7m also had major connections with the cingulate cortex (area 23), particularly the ventral bank of the cingulate sulcus. The principal subcortical connections of area 7m were with the dorsal portion of the ventrolateral thalamic (VLc) nucleus, lateral posterior thalamic nucleus, lateral pulvinar, caudal mediodorsal thalamic nucleus and medial pulvinar, central lateral, central superior lateral, and central inferior intralaminar thalamic nuclei, dorsolateral caudate nucleus and putamen, middle region of the claustrum, nucleus of the diagonal band, zona incerta, pregeniculate nucleus, anterior and posterior pretectal nuclei, intermediate layer of

Expression, purification and preliminary X-ray crystallographic analysis of the chicken MHC class I molecule YF1*7.1

International Nuclear Information System (INIS)

Hee, Chee Seng; Gao, Song; Miller, Marcia M.; Goto, Ronald M.; Ziegler, Andreas; Daumke, Oliver; Uchanska-Ziegler, Barbara

2009-01-01

The chicken classical MHC class I antigen YF1*7.1 was crystallized together with β 2 -microglobulin but without a peptide ligand. Crystals diffracted synchrotron radiation to 1.32 Å and belonged to the monoclinic space group P2 1 . YF1*7.1 is an allele of a polymorphic major histocompatibility complex (MHC) class I-like locus within the chicken Y gene complex. With the aim of understanding the possible role of the YF1*7.1 molecule in antigen presentation, the complex of YF1*7.1 heavy chain and β 2 -microglobulin was reconstituted and purified without a peptide. Crystals diffracted synchrotron radiation to 1.32 Å resolution and belonged to the monoclinic space group P2 1 . The phase problem was solved by molecular replacement. A detailed examination of the structure may provide insight into the type of ligand that could be bound by the YF1*7.1 molecule

11.72-sq cm Active-Area Wafer Interconnected PiN Diode Pulsed at 64 kA Dissipates 382 J and Exhibits an Action of 1.7 MA(sup 2)-s

Science.gov (United States)

2012-01-30

calculated action exceeded 1.7 MA2 -s. Preliminary efforts on high voltage diode interconnection have produced quarter wafer interconnected PiN...was packaged in a “hockey-puck” configuration and pulsed to 64 kA, dissipating 382 J with a calculated action exceeding 1.7 MA2 -s. II. FULL...epitaxial layers are utilized. 11.72-cm2 Active-area Wafer Interconnected PiN Diode pulsed at 64 kA dissipates 382 J and exhibits an action of 1.7 MA2 -s

The PD-1/B7-H1 pathway modulates the natural killer cells versus mouse glioma stem cells.

Directory of Open Access Journals (Sweden)

Bo Yuan Huang

Full Text Available Glioblastoma multiforme (GBM is the most malignant primary type of brain tumor in adults. There has been increased focus on the immunotherapies to treat GBM patients, the therapeutic value of natural killer (NK cells is still unknown. Programmed death-1 (PD-1 is a major immunological checkpoint that can negatively regulate the T-cell-mediated immune response. We tested the combination of the inhibiting the PD-1/B7H1 pathway with a NK-cell mediated immune response in an orthotopic mouse model of GBM.Mouse glioma stem cells (GL261GSCs and mouse NK cells were isolated and identified. A lactate dehydrogenase (LDH assay was perfomed to detect the cytotoxicity of NK cells against GL261GSCs. GL261GSCs were intracranially implanted into mice, and the mice were stratified into 3 treatment groups: 1 control, 2 NK cells treatment, and 3 PD-1 inhibited NK cells treatment group. Overall survival was quantified, and animal magnetic resonance imaging (MRI was performed to determine tumor growth. The brains were harvested after the mice were euthanized, and immunohistochemistry against CD45 and PCNA was performed.The mouse NK cells were identified as 90% CD3- NK1.1+CD335+ by flow cytometric analysis. In the LDH assay, the ratios of the damaged GL261GSCs, with the E:T ratios of 2.5:1, 5:1, and 10:1, were as follows: 1 non-inhibited group: 7.42%, 11.31%, and 15.1%, 2 B7H1 inhibited group: 14.75%, 18.25% and 29.1%, 3 PD-1 inhibited group: 15.53%, 19.21% and 29.93%, 4 double inhibited group: 33.24%, 42.86% and 54.91%. In the in vivo experiments, the mice in the PD-1 inhibited NK cells treatment group and IL-2-stimulated-NK cells treatment group displayed a slowest tumor growth (F = 308.5, P<0.01 and a slower tumor growth compared with control group (F = 118.9, P<0.01, respectively. The median survival of the mice in the three groups were as follows: 1 conrol group: 29 days, 2 NK cells treatment group: 35 days (P = 0.0012, 3 PD-1 inhibited NK cells treatment group

Stanford survives 7.1 shock

Energy Technology Data Exchange (ETDEWEB)

Riordan, Michael

1989-12-15

The Monday morning of 16 October looked like the start of a quiet week at the Stanford Linear Accelerator Center (SLAC). After a successful six-month physics run, the SLC Stanford Linear Collider was shut down to begin scheduled upgrades and the installation of two vertex detectors for the Mark II detector. Then at 5.04 p.m. the next day, the Earth's crust had had enough. A major earthquake measuring 7.1 on the Richter scale rocked the San Francisco Bay Area from an epicentre along the wicked San Andreas Fault in the Southern Santa Cruz mountains.

Stanford survives 7.1 shock

International Nuclear Information System (INIS)

Riordan, Michael

1989-01-01

The Monday morning of 16 October looked like the start of a quiet week at the Stanford Linear Accelerator Center (SLAC). After a successful six-month physics run, the SLC Stanford Linear Collider was shut down to begin scheduled upgrades and the installation of two vertex detectors for the Mark II detector. Then at 5.04 p.m. the next day, the Earth's crust had had enough. A major earthquake measuring 7.1 on the Richter scale rocked the San Francisco Bay Area from an epicentre along the wicked San Andreas Fault in the Southern Santa Cruz mountains

A "1"3"7Cs erosion model with moving boundary

International Nuclear Information System (INIS)

Yin, Chuan; Ji, Hongbing

2015-01-01

A novel quantitative model of the relationship between diffused concentration changes and erosion rates using assessment of soil losses was developed. It derived from the analysis of surface soil "1"3"7Cs flux variation under persistent erosion effect and based on the principle of geochemistry kinetics moving boundary. The new moving boundary model improves the basic simplified transport model (Zhang et al., 2008), and mainly applies to uniform rainfall areas which show a long-time soil erosion. The simulation results for this kind of erosion show under a long-time soil erosion, the influence of "1"3"7Cs concentration will decrease exponentially with increasing depth. Using the new model fit to the measured "1"3"7Cs depth distribution data in Zunyi site, Guizhou Province, China which has typical uniform rainfall provided a good fit with R"2 = 0.92. To compare the soil erosion rates calculated by the simple transport model and the new model, we take the Kaixian reference profile as example. The soil losses estimated by the previous simplified transport model are greater than those estimated by the new moving boundary model, which is consistent with our expectations. - Highlights: • The diffused moving boundary principle analysing "1"3"7Cs flux variation. • The new erosion model applies to uniform rainfall areas. • The erosion effect on "1"3"7Cs will decrease exponentially with increasing depth. • The new model provides two methods of calculating erosion rate.

18 CFR 430.7 - Determination of protected areas and restriction on water use.

Science.gov (United States)

2010-04-01

... protected areas and restriction on water use. 430.7 Section 430.7 Conservation of Power and Water Resources... Determination of protected areas and restriction on water use. In consideration of the foregoing facts and for... a protected area within the meaning and for the purpose of Article 10 of the Delaware River Basin...

Small C7-T1 lordotic angle and muscle degeneration at C7 level were independent radiological characteristics of patients with cervical imbalance: a propensity score-matched analysis.

Science.gov (United States)

Tamai, Koji; Romanu, Joshua; Grisdela, Phillip; Paholpak, Permsak; Zheng, Pengfei; Nakamura, Hiroaki; Buser, Zorica; Wang, Jeffrey C

2018-01-31

Cervical sagittal vertical axis (cSVA) of ≥40 mm is recognized as the key factor of poor health-related quality of life, poor surgical outcomes, and correction loss after surgery for cervical deformity. However, little is known about the radiological characteristics of patients with cSVA≥40 mm. The purpose of this study was to identify the radiological characteristics of patients with cervical imbalance. Retrospective analysis of weight-bearing cervical magnetic resonance (MR) images. Consecutive 1,500 MR images of symptomatic patients in weight-bearing position. Cervical sagittal vertical axis, cervical alignment, cervical balance parameters (T1 slope, Co-C2 angle, C2-C7 angle, C7-T1 angle, neck tilt, and thoracic inlet angle), disc degeneration (Pfirmann and Suzuki classification), end plate degeneration (Modic change), spondylolisthesis (antero- and retrolisthesis), anteroposterior (AP) diameter of dural sac, cross-sectional area (CSA), and fat infiltration ratio of the transversospinalis muscles at C4 and C7 levels. Patients were divided into two groups: cSVA≥40 mm and cSVAimbalance (cSVA≥40 mm) and control (imbalance was 2.5% (37 patients). Those patients had a higher incidence of kyphosis, were older, and there were more male patients. In the matched imbalance group, the T1 slope was greater (p=.028), C7-T1 lordotic angle was smaller (pimbalance. Copyright © 2018 Elsevier Inc. All rights reserved.

Nav1.7 expression is increased in painful human dental pulp

Directory of Open Access Journals (Sweden)

Levinson S Rock

2008-04-01

Full Text Available Abstract Background Animal studies and a few human studies have shown a change in sodium channel (NaCh expression after inflammatory lesions, and this change is implicated in the generation of pain states. We are using the extracted human tooth as a model system to study peripheral pain mechanisms and here examine the expression of the Nav1.7 NaCh isoform in normal and painful samples. Pulpal sections were labeled with antibodies against: 1 Nav1.7, N52 and PGP9.5, and 2 Nav1.7, caspr (a paranodal protein used to identify nodes of Ranvier, and myelin basic protein (MBP, and a z-series of optically-sectioned images were obtained with the confocal microscope. Nav1.7-immunofluorescence was quantified in N52/PGP9.5-identified nerve fibers with NIH ImageJ software, while Nav1.7 expression in myelinated fibers at caspr-identified nodal sites was evaluated and further characterized as either typical or atypical as based on caspr-relationships. Results Results show a significant increase in nerve area with Nav1.7 expression within coronal and radicular fiber bundles and increased expression at typical and atypical caspr-identified nodal sites in painful samples. Painful samples also showed an augmentation of Nav1.7 within localized areas that lacked MBP, including those associated with atypical caspr-identified sites, thus identifying NaCh remodeling within demyelinating axons as the basis for a possible pulpal pain mechanism. Conclusion This study identifies the increased axonal expression and augmentation of Nav1.7 at intact and remodeling/demyelinating nodes within the painful human dental pulp where these changes may contribute to constant, increased evoked and spontaneous pain responses that characterize the pain associated with toothache.

Remedial investigation report on Waste Area Grouping 5 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 3 -- Appendix B: Technical findings and conclusions

International Nuclear Information System (INIS)

1995-09-01

This document provides the Environmental Restoration Program with information about the results of investigations performed at Waste Area Grouping (WAG) 5. It includes information on risk assessments that have evaluated long-term impacts to human health and the environment. Information provided in this document forms the basis for decisions regarding the need for subsequent remediation work at WAG 5. Sections B1.1 through B1.4 present an overview of the environmental setting of WAG 5, including location, population, land uses, ecology, and climate, and Sects. B1.5 through B1.7 give site-specific details (e.g., topography, soils, geology, and hydrology). The remediation investigation (RI) of WAG 5 did not entail en exhaustive characterization of all physical attributes of the site; the information presented here focuses on those most relevant to the development and verification of the WAG 5 conceptual model. Most of the information presented in this appendix was derived from the RI field investigation, which was designed to complement the existing data base from earlier, site-specific studies of Solid Waste Storage Area (SWSA) 5 and related areas.

A preliminary X-ray study of d,d-heptose-1,7-bisphosphate phosphatase from Burkholderia thailandensis E264

International Nuclear Information System (INIS)

Kim, Mi-Sun; Shin, Dong Hae

2010-01-01

In this study, d,d-heptose-1,7-bisphosphate phosphatase has been cloned, expressed, purified and crystallized. d,d-Heptose-1,7-bisphosphate phosphatase (GmhB), which is involved in the third step of the NDP-heptose biosynthesis pathway, converts d,d-heptose-1,7-bisphosphate to d,d-heptose-1-phosphate. This biosynthesis pathway is a target for new antibiotics or antibiotic adjuvants for Gram-negative pathogens. Burkholderia thailandensis is a useful surrogate organism for studying the pathogenicity of melioidosis owing to its extensive genomic similarity to B. pseudomallei. Melioidosis caused by B. pseudomallei is a serious invasive disease of animals and humans in tropical and subtropical areas. In this study, GmhB has been cloned, expressed, purified and crystallized. X-ray data have also been collected to 2.50 Å resolution using synchrotron radiation. The crystal belonged to space group P6, with unit-cell parameters a = 243.2, b = 243.2, c = 41.1 Å

7 CFR 275.18 - Project area/management unit corrective action plan.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false Project area/management unit corrective action plan... SYSTEM Corrective Action § 275.18 Project area/management unit corrective action plan. (a) The State agency shall ensure that corrective action plans are prepared at the project area/management unit level...

Improving the performance of indicator groups for the identification of important areas for species conservation

DEFF Research Database (Denmark)

Larsen, Frank Wugt; Bladt, Jesper; Rahbek, Carsten

2007-01-01

Indicator groups may be important tools with which to guide the selection of networks of areas for conservation. Nevertheless, the literature provides little guidance as to what makes some groups of species more suitable than others to guide area selection. Using distributional data on all sub...... diversity by systematically varying the number of distinct genera and families within the indicator groups. We selected area networks based on the indicator groups and tested their ability to represent a set of species, which, in terms of species composition, is independent of the indicator group....... Increasing the proportion of threatened, endemic, and range-restricted species in the indicator groups improved effectiveness of the selected area networks; in particular it improved the effectiveness in representing other threatened and range-restricted species. In contrast increasing the proportion...

Data quality objectives summary report for the 100-BC-1, 100-BC-2, and 100-DR-1, and 100-DR-2 group 3 waste sites

International Nuclear Information System (INIS)

1997-03-01

The 100-BC-1, 100-BC-2, 100-DR-1, and 100-DR-2 Group 3 waste sites contain 22 past-practice liquid waste disposal sites and process effluent piping associated with four plutonium-production nuclear reactors that operated from 1944 to 1967. The 100-BC-1, 100-BC-2, 100-DR-1, and 100-DR-2 Group 3 waste sites are the third set of Hanford 100 Area sites to undergo remediation to the extent practicable. Like the sites listed in Groups 1 and 2, the Group 3 sites are considered high-priority because of the contaminants present and their proximity to the Columbia River. Remediation of the 100-BC-1, 100-HR-1 and 100-DR-1 radioactive liquid waste sites is planned to occur in two phases: The first phase, which has been completed, was a demonstration project in the 100-B/C Area to test field techniques and acquire contamination data. The second phase is full-scale remediation of all the reactor areas, starting in the 10-B/C Area, using the field experience gained in the first phase and each subsequent reactor area remediation. This document provides the DQO in support of remediation sampling and analysis at selected sites in the 100-B/C and 100-D Areas

Enhanced expression of Ang-(1-7 during pregnancy

Directory of Open Access Journals (Sweden)

Brosnihan K.B.

2004-01-01

Full Text Available Pregnancy is a physiological condition characterized by a progressive increase of the different components of the renin-angiotensin system (RAS. The physiological consequences of the stimulated RAS in normal pregnancy are incompletely understood, and even less understood is the question of how this system may be altered and contribute to the hypertensive disorders of pregnancy. Findings from our group have provided novel insights into how the RAS may contribute to the physiological condition of pregnancy by showing that pregnancy increases the expression of both the vasodilator heptapeptide of the RAS, angiotensin-(1-7 [Ang-(1-7], and of a newly cloned angiotensin converting enzyme (ACE homolog, ACE2, that shows high catalytic efficiency for Ang II metabolism to Ang-(1-7. The discovery of ACE2 adds a new dimension to the complexity of the RAS by providing a new arm that may counter-regulate the activity of the vasoconstrictor component, while amplifying the vasodilator component. The studies reviewed in this article demonstrate that Ang-(1-7 increases in plasma and urine of normal pregnant women. In preeclamptic subjects we showed that plasma Ang-(1-7 was suppressed as compared to the levels found in normal pregnancy. In addition, kidney and urinary levels of Ang-(1-7 were increased in pregnant rats coinciding with the enhanced detection and expression of ACE2. These findings support the concept that in normal pregnancy enhanced ACE2 may counteract the elevation in tissue and circulating Ang II by increasing the rate of conversion to Ang-(1-7. These findings provide a basis for the physiological role of Ang-(1-7 and ACE2 during pregnancy.

OPERATION CASTLE. The Operation Plan Number 1-53. Task Group 7.1

Science.gov (United States)

1984-08-31

83-C-0286 with the close cooperation of the Classification • Management Division of the Defense Nuclear Agency. 19 KEY WORDS (Conltnue on reverse side...Day on which k5th Shot) will be detonated. R-DAY (RC*(E.) - fay on which (6th Shot) will be detonated. -5- I o K-DAY ( KOON ) - Day on which (7th Shot...timing signals to meet the principle requirements of the experimental prograraz. (2) Supplies the firing pulse to the device(s) to be tested. (3

The PD-1/B7-H1 pathway modulates the natural killer cells versus mouse glioma stem cells.

Science.gov (United States)

Huang, Bo Yuan; Zhan, Yi Ping; Zong, Wen Jing; Yu, Chun Jiang; Li, Jun Fa; Qu, Yan Ming; Han, Song

2015-01-01

Glioblastoma multiforme (GBM) is the most malignant primary type of brain tumor in adults. There has been increased focus on the immunotherapies to treat GBM patients, the therapeutic value of natural killer (NK) cells is still unknown. Programmed death-1 (PD-1) is a major immunological checkpoint that can negatively regulate the T-cell-mediated immune response. We tested the combination of the inhibiting the PD-1/B7H1 pathway with a NK-cell mediated immune response in an orthotopic mouse model of GBM. Mouse glioma stem cells (GL261GSCs) and mouse NK cells were isolated and identified. A lactate dehydrogenase (LDH) assay was perfomed to detect the cytotoxicity of NK cells against GL261GSCs. GL261GSCs were intracranially implanted into mice, and the mice were stratified into 3 treatment groups: 1) control, 2) NK cells treatment, and 3) PD-1 inhibited NK cells treatment group. Overall survival was quantified, and animal magnetic resonance imaging (MRI) was performed to determine tumor growth. The brains were harvested after the mice were euthanized, and immunohistochemistry against CD45 and PCNA was performed. The mouse NK cells were identified as 90% CD3- NK1.1+CD335+ by flow cytometric analysis. In the LDH assay, the ratios of the damaged GL261GSCs, with the E:T ratios of 2.5:1, 5:1, and 10:1, were as follows: 1) non-inhibited group: 7.42%, 11.31%, and 15.1%, 2) B7H1 inhibited group: 14.75%, 18.25% and 29.1%, 3) PD-1 inhibited group: 15.53%, 19.21% and 29.93%, 4) double inhibited group: 33.24%, 42.86% and 54.91%. In the in vivo experiments, the mice in the PD-1 inhibited NK cells treatment group and IL-2-stimulated-NK cells treatment group displayed a slowest tumor growth (F = 308.5, Pmouse NK cells to kill the GL261GSCs, and the PD-1-inhibited NK cells could be a feasible immune therapeutic approach against GBM.

Crystal structures of CCa2CuO5 and CSr1.9Ca1.1Cu2O7 refined from single crystal data

International Nuclear Information System (INIS)

Kopnin, E.M.; Matveev, A.T.; Salamakha, P.S.; Sato, A.; Takayama-Muromachi, E.

2003-01-01

Single crystals were grown for new layered oxycarbonates CCa 2 CuO 5 and CSr 1.9 Ca 1.1 Cu 2 O 7 at 6 GPa using a belt-type apparatus. Their crystal structures were determined using single crystal X-ray diffraction data with R1(wR2)=0.0294(0.0659) and 0.0199(0.0457) for CCa 2 CuO 5 and CSr 1.9 Ca 1.1 Cu 2 O 7 , respectively. These phases crystallize in the space group P4/mmm (No. 123), Z=1 with a=3.8157(1) Angst, c=7.1426(3) Angst for CCa 2 CuO 5 and a=3.8753(1) Angst, c=10.6765(5) Angst for CSr 1.9 Ca 1.1 Cu 2 O 7 . In contrast to CSr 2 CuO 5 , no ordering in the orientation of the triangular CO 3 groups was revealed in CCa 2 CuO 5 and CSr 1.9 Ca 1.1 Cu 2 O 7

Comparative study of "1"3"7Cs distribution in broilers and pheasants and possibilities for protection

International Nuclear Information System (INIS)

Mitrovic, Branislava M.; Vitorovic, Gordana; Lazarevic-Macanovic, Mirjana; Vicentijevic, Mihajlo; Vitorovic, Dusko; Pantelic, Gordana

2012-01-01

The aim of the present study was to investigate distribution of "1"3"7Cs in leg and breast meat of broilers and pheasants following single alimentary contamination and administration of two protectors (AFCF and clinoptilolite). The birds were administered a single dose of "1"3"7CsCl, with an activity of 750 Bq. Protectors were given via gastric tube or mixed in the forage pellets. AFCF given via gastric tube decreased the "1"3"7Cs concentration by a factor of 7.8 in broilers leg meat and 7.4 in broilers breast meat. When AFCF was mixed in pellets, the "1"3"7Cs concentration was 19.5 times lower in broilers leg meat and 22.1 times lower in broilers breast meat, than in the control group. In pheasants, AFCF administered via gastric tube decreased the "1"3"7Cs concentration by a factor of 12.4 in leg meat and by a factor of 13.7 in breast meat, respectively. In group 4, where pheasants were administered AFCF mixed in pellets, the "1"3"7Cs concentration was 3.7 times lower in leg and breast meat, than in the control group. For comparison, clinoptilolite administered via gastric tube decreased the "1"3"7Cs concentration 1.8 times in broilers leg meat and 2.0 times in breast meat, compared to the control group. In pheasants, "1"3"7Cs concentration was 2.9 times lower in leg meat and 2.6 times lower in breast meat. Clinoptilolite mixed in the feed had relatively low efficiency of protection in broilers ("1"3"7Cs concentration was 1.4 times lower in leg meat and 1.6 lower in breast meat). A similar trend was observed in pheasants ("1"3"7Cs concentration was 1.6 lower in leg and breast meat). (orig.)

36 CFR 7.71 - Delaware Water Gap National Recreation Area.

Science.gov (United States)

2010-07-01

... THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.71 Delaware Water Gap National... route begins at the Smithfield Beach parking area and is in two loops. Loop One is a small trail... number of axles and wheels on a vehicle, regardless of load or weight, as follows: (i) Two-axle car, van...

Cochrane Acute Respiratory Infections Group's Stakeholder Engagement Project identified systematic review priority areas.

Science.gov (United States)

Scott, Anna Mae; Clark, Justin; Dooley, Liz; Jones, Ann; Jones, Mark; Del Mar, Chris

2018-05-22

Cochrane Acute Respiratory Infections (ARI) Group conducts systematic reviews of the evidence for treatment and prevention of ARIs. We report the results of a prioritisation project, aiming to identify highest priority systematic review topics. The project consisted of 2 Phases. Phase 1 analysed the gap between existing RCTs and Cochrane Systematic Reviews (reported previously). Phase 2 (reported here) consisted of a two-round survey. In round 1, respondents prioritised 68 topics and suggested up to 10 additional topics; in Round 2, respondents prioritised top 25 topics from Round 1. Respondents included clinicians, researchers, systematic reviewers, allied health, patients, and carers, from 33 different countries. In Round 1, 154 respondents identified 20 priority topics, most commonly selecting topics in non-specific ARIs, influenza, and common cold. 50 respondents also collectively suggested 134 additional topics. In Round 2, 78 respondents prioritised top 25 topics, most commonly in the areas of non-specific ARIs, pneumonia and influenza. We generated a list of priority systematic review topics, to guide the Cochrane ARI Group's systematic review work for the next 24 months. Stakeholder involvement enhanced the transparency of the process, and will increase the usability and relevance of the Group's work to stakeholders. Copyright © 2018 Elsevier Inc. All rights reserved.

7 CFR 29.9404 - Marketing area opening dates and marketing schedules.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Marketing area opening dates and marketing schedules... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY....9404 Marketing area opening dates and marketing schedules. (a) The Flue-Cured Tobacco Advisory...

Trichloro(1,4,7-trimethyl-1,4,7-triazacyclononane)chromium(III)

DEFF Research Database (Denmark)

Klitgaard, Søren Kegnaes; Schau-Magnussen, Magnus

2005-01-01

The 1,4,7-trimethyl-1,4,7-triazacyclononane (tmtacn) ligand has become one of the classic ligands in coordination chemistry (Wieghardt et al., 1982 [Wieghardt, K., Chaudhuri, P., Nuber, B. & Weiss, J. (1982). Inorg. Chem. 21, 3086-3090.] ). In recent years, tmtacn-metal complexes ...

GIS-based identification of areas with mineral resource potential for six selected deposit groups, Bureau of Land Management Central Yukon Planning Area, Alaska

Science.gov (United States)

Jones, James V.; Karl, Susan M.; Labay, Keith A.; Shew, Nora B.; Granitto, Matthew; Hayes, Timothy S.; Mauk, Jeffrey L.; Schmidt, Jeanine M.; Todd, Erin; Wang, Bronwen; Werdon, Melanie B.; Yager, Douglas B.

2015-01-01

This study, covering the Bureau of Land Management (BLM) Central Yukon Planning Area (CYPA), Alaska, was prepared to aid BLM mineral resource management planning. Estimated mineral resource potential and certainty are mapped for six selected mineral deposit groups: (1) rare earth element (REE) deposits associated with peralkaline to carbonatitic intrusive igneous rocks, (2) placer and paleoplacer gold, (3) platinum group element (PGE) deposits associated with mafic and ultramafic intrusive igneous rocks, (4) carbonate-hosted copper deposits, (5) sandstone uranium deposits, and (6) tin-tungsten-molybdenum-fluorspar deposits associated with specialized granites. These six deposit groups include most of the strategic and critical elements of greatest interest in current exploration.

Removal action work plan for Corehole 8 in Waste Area Grouping 1 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1994-11-01

The objective of the Waste Area Grouping 1 Corehole 8 Removal Action is to collect strontium-90 contaminated groundwater that is currently being discharged from existing storm drains into First Creek. 90 Sr has been identified as a major contributor to potential risk offsite. First Creek contributes about 10% of the 90 Sr contamination detected at White Oak Dam. This Removal Action Work Plan (RAWP) addresses construction of new french drains, gravity piping, and a pressure sewer pipeline to collect and pump the contaminated water to Manhole 24. The contaminated water will then flow through existing pipes to the Process Waste Treatment Plant for treatment. The proposed scope of work for this project includes the installation of approximately 480 ft of high-density polyethylene gravity piping, with cleanouts, to transport the contaminated water to a proposed pumping station. The contaminated water will then be pumped from the new pump station approximately 1,140 ft through a new force main to Manhole 24. This project will reduce the quantity of 90 Sr contaminated groundwater entering First Creek

Group Authentication Scheme for Neighbourhood Area Networks (NANs in Smart Grids

Directory of Open Access Journals (Sweden)

Bashar Alohali

2016-05-01

Full Text Available A Neighbourhood Area Network is a functional component of the Smart Grid that interconnects the end user domain with the Energy Services Provider (ESP domain. It forms the “edge” of the provider network, interconnecting homes instrumented with Smart Meters (SM with the ESP. The SM is a dual interface, wireless communication device through which information is transacted across the user (a home and ESP domains. The security risk to the ESP increases since the components within the home, interconnected to the ESP via the SM, are not managed by the ESP. Secure operation of the SM is a necessary requirement. The SM should be resilient to attacks, which might be targeted either directly or via the network in the home. This paper presents and discusses a security scheme for groups of SMs in a Neighbourhood Area Network that enable entire groups to authenticate themselves, rather than one at a time. The results show that a significant improvement in terms of resilience against node capture attacks, replay attacks, confidentiality, authentication for groups of SMs in a NAN that enable entire groups to authenticate themselves, rather than one at a time.

Classification of the maxillary sinus according to area of the medial antral wall: a comparison of two ethnic groups.

Science.gov (United States)

Lee, Fernandes Carmen; Fernandes, C M C; Murrell, H C

2009-06-01

This study is an anatomical study designed to benefit surgeons working in the region of the maxillary sinus. This paper investigates ethnic and gender variations in the shape of the maxillary sinus in dried crania from the Raymond Dart collection of human skeletons. The paper claims that an estimate of the area of the medial antral wall of the maxillary sinus is one of the best ethnic/gender group predictors. Helical, multislice computed tomography was performed using 1mm coronal slices length, depth, width and volume measurements for each sinus were taken. Classification by shape and estimated area of medial wall was attempted. Shape classification was found to be unsuccessful whilst medial wall classification into ethnic/gender groupings gave encouraging results. The area of the medial wall is related to ethnic/gender groups.

39 CFR 7.1 - Definitions.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Definitions. 7.1 Section 7.1 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE PUBLIC OBSERVATION (ARTICLE VII) § 7.1 Definitions. For purposes of §§ 7.2 through 7.8 of these bylaws: (a) The term Board means the...

Activity of CERN and LNF groups on large area GEM detectors

Energy Technology Data Exchange (ETDEWEB)

Alfonsi, M. [CERN, Geneva (Switzerland); Bencivenni, G. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Brock, I. [Physikalisches Institute der Universitat Bonn, Bonn (Germany); Cerioni, S. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Croci, G.; David, E. [CERN, Geneva (Switzerland); De Lucia, E. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); De Oliveira, R. [CERN, Geneva (Switzerland); De Robertis, G. [Sezione INFN di Bari, Bari (Italy); Domenici, D., E-mail: Danilo.Domenici@lnf.infn.i [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Duarte Pinto, S. [CERN, Geneva (Switzerland); Felici, G.; Gatta, M.; Jacewicz, M. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Loddo, F. [Sezione INFN di Bari, Bari (Italy); Morello, G. [Dipeartimento di Fisica Universita della Calabria e INFN, Cosenza (Italy); Pistilli, M. [Laboratori Nazionali di Frascati dell' INFN, Frascati (Italy); Ranieri, A. [Sezione INFN di Bari, Bari (Italy); Ropelewski, L. [CERN, Geneva (Switzerland); Sauli, F. [TERA Foundation, Novara (Italy)

2010-05-21

We report on the activity of CERN and INFN-LNF groups on the development of large area GEM detectors. The two groups work together within the RD51 Collaboration, to aim at the development of Micro-pattern Gas detectors technologies. The vast request for large area foils by the GEM community has driven a change in the manufacturing procedure by the TS-DEM-PMT laboratory, needed to overcome the previous size limitation of 450x450mm{sup 2}. Now a single-mask technology is used allowing foils to be made as large as 450x2000mm{sup 2}. The limitation in the short size, due to the definite width of the raw material, can be overcome by splicing more foils together. A 10x10cm{sup 2} GEM detector with the new single-mask foil has been tested with X-rays and the results are shown. Possible future applications for large area GEM are the TOTEM experiment upgrade at CERN, and the KLOE-2 experiment at the Dafne {Phi}-factory in Frascati.

Activity of CERN and LNF groups on large area GEM detectors

International Nuclear Information System (INIS)

Alfonsi, M.; Bencivenni, G.; Brock, I.; Cerioni, S.; Croci, G.; David, E.; De Lucia, E.; De Oliveira, R.; De Robertis, G.; Domenici, D.; Duarte Pinto, S.; Felici, G.; Gatta, M.; Jacewicz, M.; Loddo, F.; Morello, G.; Pistilli, M.; Ranieri, A.; Ropelewski, L.; Sauli, F.

2010-01-01

We report on the activity of CERN and INFN-LNF groups on the development of large area GEM detectors. The two groups work together within the RD51 Collaboration, to aim at the development of Micro-pattern Gas detectors technologies. The vast request for large area foils by the GEM community has driven a change in the manufacturing procedure by the TS-DEM-PMT laboratory, needed to overcome the previous size limitation of 450x450mm 2 . Now a single-mask technology is used allowing foils to be made as large as 450x2000mm 2 . The limitation in the short size, due to the definite width of the raw material, can be overcome by splicing more foils together. A 10x10cm 2 GEM detector with the new single-mask foil has been tested with X-rays and the results are shown. Possible future applications for large area GEM are the TOTEM experiment upgrade at CERN, and the KLOE-2 experiment at the Dafne Φ-factory in Frascati.

Group-decoupled multi-group pin power reconstruction utilizing nodal solution 1D flux profiles

International Nuclear Information System (INIS)

Yu, Lulin; Lu, Dong; Zhang, Shaohong; Wang, Dezhong

2014-01-01

Highlights: • A direct fitting multi-group pin power reconstruction method is developed. • The 1D nodal solution flux profiles are used as the condition. • The least square fit problem is analytically solved. • A slowing down source improvement method is applied. • The method shows good accuracy for even challenging problems. - Abstract: A group-decoupled direct fitting method is developed for multi-group pin power reconstruction, which avoids both the complication of obtaining 2D analytic multi-group flux solution and any group-coupled iteration. A unique feature of the method is that in addition to nodal volume and surface average fluxes and corner fluxes, transversely-integrated 1D nodal solution flux profiles are also used as the condition to determine the 2D intra-nodal flux distribution. For each energy group, a two-dimensional expansion with a nine-term polynomial and eight hyperbolic functions is used to perform a constrained least square fit to the 1D intra-nodal flux solution profiles. The constraints are on the conservation of nodal volume and surface average fluxes and corner fluxes. Instead of solving the constrained least square fit problem numerically, we solve it analytically by fully utilizing the symmetry property of the expansion functions. Each of the 17 unknown expansion coefficients is expressed in terms of nodal volume and surface average fluxes, corner fluxes and transversely-integrated flux values. To determine the unknown corner fluxes, a set of linear algebraic equations involving corner fluxes is established via using the current conservation condition on all corners. Moreover, an optional slowing down source improvement method is also developed to further enhance the accuracy of the reconstructed flux distribution if needed. Two test examples are shown with very good results. One is a four-group BWR mini-core problem with all control blades inserted and the other is the seven-group OECD NEA MOX benchmark, C5G7

Migration of a groundwater contaminant plume by stratabound flow in Waste Area Grouping 1 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Ketelle, R.H.; Lee, R.R.

1992-08-01

The discovery of radiologically contaminated groundwater in core hole CH-8 in the western portion of Waste Area Grouping (WAG) 1 at Oak Ridge National Laboratory (ORNL) prompted a detailed investigation to identify the contaminant plume. Utilizing a working hypothesis of stratabound groundwater flow and contaminant transport, investigators analyzed existing subsurface geologic data to predict the contaminant plume discharge location in first Creek and locations of contaminated groundwater seepage into storm drains. The hypothesis states that differential lithologic/fracture conditions lead to the development of preferred flow and transport pathways, of discrete vertical extent, which may not be coincident with the hydraulic gradient. Leakage out of the stratabound pathway is a minor component of the overall plume configuration

Toxicity of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) in three vertebrate species.

Science.gov (United States)

Johnson, Mark S; McFarland, Craig A; Bazar, Matthew A; Quinn, Michael J; LaFiandra, Emily May; Talent, Larry G

2010-04-01

The explosive, octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine or high-melting explosive (HMX), has been found in soils in areas used for testing and training by the military. Many of these areas contain habitat for valued wildlife species. In an effort to better understand the environmental consequences from exposure, a reptilian (western fence lizard [Sceloporus occidentalis]), an amphibian (red-backed salamander [Plethodon cinereus]), and a mammalian species (rabbit [Oryctolagus cuniculus]) were exposed to HMX under controlled laboratory conditions. Lizards and rabbits were exposed to HMX by way of corn oil through gavage, and salamanders were exposed to HMX in soil. Two deaths occurred from acute oral exposures to lizards to 5000 mg HMX/kg BW. Histological and gross pathologic assessment suggested gut impaction as a possible cause of death. Salamanders exposed to concentrations of HMX in soil 24 h after oral exposures. An LD(50) for rabbits was calculated as 93 mg/kg (95% confidence interval 76-117). A subacute 14-day testing regime found a lowest observed effect level of 10 mg/kg-d and a no observed adverse effect level of 5 mg/kg-d based on hyperkinesia and seizure incidence, although changes suggesting functional hepatic alterations were also found. These data suggest that physiologic differences between species, particularly in gastrointestinal structure and function, can affect the absorption of HMX and hence lead to marked differences in toxicity from exposure to the same compound.

Summary Report of Working Group 7: Muon Colliders and Advanced Concepts

Energy Technology Data Exchange (ETDEWEB)

Nagaitsev, Sergei [Fermilab; Berg, J.Scott [Brookhaven

2012-07-01

The primary subject of working group 7 at the 2012 Advanced Accelerator Concepts Workshop was muon accelerators for a muon collider or neutrino factory. Additionally, this working group included topics that did not fit well into other working groups. Two subjects were discussed by more than one speaker: lattices to create a perfectly integrable nonlinear lattice, and a Penning trap to create antihydrogen.

Dorsiflexor muscle-group thickness in children with cerebral palsy: Relation to cross-sectional area

DEFF Research Database (Denmark)

Bandholm, Thomas; Magnusson, Peter; Jensen, Bente Rona

2009-01-01

If the thickness and cross-sectional area of the dorsiflexor muscle group are related in children with cerebral palsy, measurements of muscle thickness may be used to monitor changes in muscle size due to training or immobilisation in these patients. We assessed the validity and reliability.......001), and the reliability of the muscle-thickness measurements was high in the healthy subjects (ICC_{2.1} = 0.94, standard error of measurement = 0.04 cm). The dorsiflexor muscle-thickness was 22% less in the affected compared to the non-affected leg in children with hemiplegic cerebral palsy (P ..., the dorsiflexor cross-sectional area was 32% less in the affected compared to the non-affected leg (P = 0.002). Measurements of dorsiflexor muscle-thickness can be reliably obtained, and they reflect dorsiflexor cross-sectional area in children with cerebral palsy....

Brazilian pediatric research groups, lines of research, and main areas of activity

Directory of Open Access Journals (Sweden)

Priscila H.A. Oliveira

2015-05-01

Conclusions: The pediatric research groups in Brazil have relevant scientific production, including works published in international publications, and are concentrated in regions with higher socioeconomic index. Most groups registered in CNPq started their activity in the last five years (46%, reflecting the recent growth of scientific production in this area.

Aerial gamma ray and magnetic survey, Montrose detail Area 1, Colorado. Final report

International Nuclear Information System (INIS)

1980-05-01

The Montrose Detail Area No. 1 covers a 150 square mile area near the central portion of the San Juan Volcanic Region. The areas' geology is completely dominated by Tertiary volcanic events and subsequent surficial modifications. A group of 25 groups of samples in the uranium window constitute anomalies as defined in Volume I. These anomalies lie over the highest uranium, thorium, and potassium count rate areas primarily in the La Garita Mountains and the South Fork Saquache Creek drainage. Highest count rates appear to be associated with certain tuffaceous units as mapped. High gradients completely dominate the magnetic signature of the area. Little correlation with the radiometric data was expected or observed. The region appeared geochemically homogenous on the basis of radiometric data according to the criteria set forth in Volume I

The features of nucleophilic substitution of the nitro group in 4-alkyl-6-nitro-1,2,4-triazolo[5,1-c][1,2,4]triazines

Directory of Open Access Journals (Sweden)

E. N. Ulomsky

2017-05-01

Full Text Available The nucleophilic substitution of the nitro group of 4-alkyl-6-nitro-4,7-dihydro-1,2,4-triazolo[5,1-c][1,2,4]triazine-7-ones on the example of interactionwith morpholine was studied. It is established that under the action of excess cycloalkylimine at room temperature the unusual easy disclosure of triazine cycle with the formation of sterically hindered hydrazones occurs which are the key intermediates for further transformations. The carrying of reaction at elevated temperatures leads to the formation of products of substitution of the nitro group with the amine and also with morpholyl hydrazones which are the products of hydrolysis of amides of hydrazones and subsequent decarboxylation. Thus, the nucleophilic substitution of the nitro group in the described triazolotriazines flows through the ANRORC mechanism.

7 CFR 600.9 - Major land resource area soil survey offices.

Science.gov (United States)

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Major land resource area soil survey offices. 600.9 Section 600.9 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL ORGANIZATION § 600.9 Major land resource area soil survey offices. The United States is divide...

Number of Heat Wave Deaths by Diagnosis, Sex, Age Groups, and Area, in Slovenia, 2015 vs. 2003

Science.gov (United States)

Perčič, Simona; Kukec, Andreja; Cegnar, Tanja; Hojs, Ana

2018-01-01

Background: Number of deaths increases during periods of elevated heat. Objectives: To examine whether differences in heat-related deaths between 2003 and 2015 occurred in Slovenia. Materials and Methods: We estimated relative risks for deaths for the observed diagnoses, sex, age, and area, as well as 95% confidence intervals and excess deaths associated with heat waves occurring in 2015 and 2003. For comparison between 2015 and 2003, we calculated relative risks ratio and 95% confidence intervals. Results: Statistically significant in 2015 were the following: age group 75+, all causes of deaths (RR = 1.10, 95% CI 1.00–1.22); all population, circulatory system diseases (RR = 1.14, 95% CI 1.01–1.30) and age group 75+, diseases of circulatory system (RR = 1.17, 95% CI 1.01–1.34). Statistically significant in 2003 were the following: female, age group 5–74, circulatory system diseases (RR = 1.69, 95% CI 1.08–2.62). Discussion: Comparison between 2015 and 2003, all, circulatory system diseases (RRR = 1.25, 95% CI 1.01–1.55); male, circulatory system diseases (RRR = 1.85, 95% CI 1.41–2.43); all, age group 75+ circulatory system diseases (RRR = 1.34, 95% CI 1.07–1.69); male, age group 75+, circulatory system diseases (RRR = 1.52, 95% CI 1.03–2.25) and female, age group 75+, circulatory system diseases (RRR = 1.43, 95% CI 1.08–1.89). Conclusions: Public health efforts are urgent and should address circulatory system causes and old age groups. PMID:29361792

Does taxonomic diversity in indicator groups influence their effectiveness in identifying priority areas for species conservation?

DEFF Research Database (Denmark)

Bladt, Jesper Stentoft; Larsen, Frank Wugt; Rahbek, Carsten

2008-01-01

The identification of priority areas for biodiversity conservation is a cornerstone of systematic conservation planning. However, biodiversity, or even the distribution of all species, cannot be directly quantified, due to the inherent complexity of natural systems. Species indicator groups may...... serve as important tools for the identification of priority areas for conservation. Yet, it is unclear which factors make certain indicator groups perform better than others. In this study, using data on the Danish distribution of 847 species of plants, vertebrates and insects, we assessed whether...... the taxonomic diversity in species indicator groups influence their effectiveness in the identification of priority areas for species conservation. We tested whether indicator groups comprising a higher taxonomic diversity (i.e. indicator groups consisting of species from many different taxonomic groups...

7 CFR 3415.10 - Establishment and operation of peer review groups.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishment and operation of peer review groups... ASSESSMENT RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3415.10 Establishment and operation of peer review groups. Subject to § 3415.5, the Administrator shall adopt procedures...

7 CFR 3400.10 - Establishment and operation of peer review groups.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishment and operation of peer review groups... GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3400.10 Establishment and operation of peer review groups. Subject to § 3400.5, the Administrator will adopt procedures for the...

7 CFR 3411.10 - Establishment and operation of peer review groups.

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Establishment and operation of peer review groups... INITIATIVE COMPETITIVE GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3411.10 Establishment and operation of peer review groups. Subject to § 3411.5, the Administrator shall adopt procedures...

Nominal group technique: a brainstorming tool for identifying areas to improve pain management in hospitalized patients.

Science.gov (United States)

Peña, Adolfo; Estrada, Carlos A; Soniat, Debbie; Taylor, Benjamin; Burton, Michael

2012-01-01

Pain management in hospitalized patients remains a priority area for improvement; effective strategies for consensus development are needed to prioritize interventions. To identify challenges, barriers, and perspectives of healthcare providers in managing pain among hospitalized patients. Qualitative and quantitative group consensus using a brainstorming technique for quality improvement-the nominal group technique (NGT). One medical, 1 medical-surgical, and 1 surgical hospital unit at a large academic medical center. Nurses, resident physicians, patient care technicians, and unit clerks. Responses and ranking to the NGT question: "What causes uncontrolled pain in your unit?" Twenty-seven health workers generated a total of 94 ideas. The ideas perceived contributing to a suboptimal pain control were grouped as system factors (timeliness, n = 18 ideas; communication, n = 11; pain assessment, n = 8), human factors (knowledge and experience, n = 16; provider bias, n = 8; patient factors, n = 19), and interface of system and human factors (standardization, n = 14). Knowledge, timeliness, provider bias, and patient factors were the top ranked themes. Knowledge and timeliness are considered main priorities to improve pain control. NGT is an efficient tool for identifying general and context-specific priority areas for quality improvement; teams of healthcare providers should consider using NGT to address their own challenges and barriers. Copyright © 2011 Society of Hospital Medicine.

Field Sampling and Analysis Plan for the Remedial Investigation of Waste Area Grouping 2 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1992-10-01

This report provides responses to US Environmental Protection Agency Region IV EPA-M and Tennessee Department of Environment and Conservation Oversite Division (TDEC-O) comments on report ORNL/ER-58, Field Sampling and Analysis Plan for the Remedial Investigation of Waste Area Grouping 2 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Waste Area Grouping (WAG) 2 consists of the White Oak Creek (WOC) drainage system downgradient of the major ORNL WAGs in the WOC watershed. A strategy for the remedial investigation (RI) of WAG2 was developed in report ES/ER-14 ampersand Dl, Remedial Investigation Plan for Waste Area Grouping 2 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. This strategy takes full advantage of WAG2's role as an integrator of contaminant releases from the ORNL WAGs in the WOC watershed, and takes full advantage of WAG2's role as a conduit for contaminants from the ORNL site to the Clinch River. The strategy calls for a multimedia environmental monitoring and characterization program to be conducted in WAG2 while upgradient contaminant sources are being remediated. This monitoring and characterization program will (1) identify and quantify contaminant fluxes, (2) identify pathways of greatest concern for human health and environmental risk, (3) improve conceptual models of contaminant movement, (4) support the evaluation of remedial alternatives, (5) support efforts to prioritize sites for remediation, (6) document the reduction in contaminant fluxes following remediation, and (7) support the eventual remediation of WAG2. Following this strategy, WAG2 has been termed an ''integrator WAG,'' and efforts in WAG2 over the short term are directed toward supporting efforts to remediate the contaminant ''source WAGS'' at ORNL

27 CFR 7.1 - General.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false General. 7.1 Section 7.1... TREASURY LIQUORS LABELING AND ADVERTISING OF MALT BEVERAGES Scope § 7.1 General. The regulations in this part relate to the labeling and advertising of malt beverages. ...

3000 Area Phase 1 environmental assessment

International Nuclear Information System (INIS)

Ranade, D.G.

1995-09-01

The US Department of Energy (DOE) is planning to sell the 3000 Area to prospective buyers. Environmental Services was requested by the WHC Economic Transition group to assess potential environmental liabilities in the area. Historical review of the area indicated that the site was the location of ''Camp Hanford'' in 1951 and has been used for a variety of purposes since then. The activities in the area have changed over the years. A number of Buildings from the area have been demolished and at least 15 underground storage tanks (USTs) have been removed. Part of the 3000 Area was identified as Operable Unit 1100-EM-3 in the Tri-Party Agreement and was cleaned up by the US Army Corps of Engineers (USACE). The cleanup included removal of contaminated soil and USTS. WHC and ICF KH had also performed sampling and analysis at some locations in the 3000 Area prior to USACE's work on the Operable Unit 1100-EM-3. They removed a number of USTs and performed remediation

2006 Annual Operations Report for INTEC Operable Unit 3-13, Group 1, Tank Farm Interim Action

International Nuclear Information System (INIS)

D. E. Shanklin

2007-01-01

This annual operations report describes the requirements followed and activities conducted to inspect, monitor, and maintain the items installed during performance of the Waste Area Group 3, Operable Unit 3-13, Group 1, Tank Farm Interim Action, at the Idaho Nuclear Technology and Engineering Center. This report covers the time period from January 1 through December 31, 2006, and describes inspection and monitoring activities for the surface-sealed areas within the tank farm, concrete-lined ditches and culverts in and around the tank farm, the lift station, and the lined evaporation pond. These activities are intended to assure that the interim action is functioning adequately to meet the objectives stated in the Operable Unit 3-13, Record of Decision for the Group 1, Tank Farm Interim Action (DOE/ID-10660) as described in the Group 1 Remedial Design/Remedial Action Work Plan (DOE/ID-10772)

A facile synthesis of sodium 3-[1-[sup 14]C]-ethyl-7-isopropyl-1-azulenesulfonate

Energy Technology Data Exchange (ETDEWEB)

Shimada, Takeshi; Yanagisawa, Takashi; Tomiyama, Tsuyoshi [Kotobuki Pharmaceutical Co. Ltd., Nagano (Japan). Research Labs.; Okazaki, Mitsuo [Shinshu Univ., Nagano (Japan). Dept. of Applied Biology

1994-01-01

Sodium 3-ethyl-7-isopropyl-1-azulenesulfonate 1, a new therapeutic agent for stomatitis, pharyngitis and ophthalmia was labelled with carbon-14 in the ethyl group attached to the azulene ring for use in metabolic studies. [sup 14]C-labelled 1 with a specific activity of 1.98 GBq/mmol was prepared in four steps in 39.3% overall chemical yield from [1-[sup 14]C]acetic acid sodium salt. (Author).

77 FR 71492 - Amendment of Area Navigation Route Q-1; CA

Science.gov (United States)

2012-12-03

...) route Q-1. This action corrects the spelling of the TOCOS waypoint. DATES: Effective date 0901 UTC... discovered in the spelling of the TOCOS waypoint. Area Navigation Routes are published in paragraph 6011 of..., second column, line 15, remove ``TACOS'' and insert ``TOCOS.'' On page 65462, line 7, remove ``TACOS...

Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.

Science.gov (United States)

Heo, Inha; Ha, Minju; Lim, Jaechul; Yoon, Mi-Jeong; Park, Jong-Eun; Kwon, S Chul; Chang, Hyeshik; Kim, V Narry

2012-10-26

RNase III Drosha initiates microRNA (miRNA) maturation by cleaving a primary miRNA transcript and releasing a pre-miRNA with a 2 nt 3' overhang. Dicer recognizes the 2 nt 3' overhang structure to selectively process pre-miRNAs. Here, we find that, unlike prototypic pre-miRNAs (group I), group II pre-miRNAs acquire a shorter (1 nt) 3' overhang from Drosha processing and therefore require a 3'-end mono-uridylation for Dicer processing. The majority of let-7 and miR-105 belong to group II. We identify TUT7/ZCCHC6, TUT4/ZCCHC11, and TUT2/PAPD4/GLD2 as the terminal uridylyl transferases responsible for pre-miRNA mono-uridylation. The TUTs act specifically on dsRNAs with a 1 nt 3' overhang, thereby creating a 2 nt 3' overhang. Depletion of TUTs reduces let-7 levels and disrupts let-7 function. Although the let-7 suppressor, Lin28, induces inhibitory oligo-uridylation in embryonic stem cells, mono-uridylation occurs in somatic cells lacking Lin28 to promote let-7 biogenesis. Our study reveals functional duality of uridylation and introduces TUT7/4/2 as components of the miRNA biogenesis pathway. Copyright © 2012 Elsevier Inc. All rights reserved.

26 CFR 1.199-7 - Expanded affiliated groups.

Science.gov (United States)

2010-04-01

... expenses in creating an intangible asset and deducts these expenses in 2007. P anticipates that it will license the intangible asset to S. On January 1, 2008, P licenses the intangible asset to S for $2,500. S uses the intangible asset in manufacturing QPP within the United States. S incurs $2,000 of additional...

[Professional quality of life in workers of the Toledo primary care health area].

Science.gov (United States)

Villarín Castro, A; Méndez García, T; Zuzuárregui Gironés, M S; Sánchez Serrano, S; Conejo Ocaña, R

2015-01-01

To determine the professional quality of life in the workers of the Toledo Primary Care Health Area and to analyse its components. Descriptive, cross-sectional study, performed on workers of the Toledo Primary Care Health Area with an online self-administered questionnaire. age, sex, health centre, professional group, seniority, management experience, collaboration in working groups, employment situation, and the PQL-35 professional quality of life questionnaire. A total of 430 completed questionnaires were received (45.3%), of which 68.4% were women. The mean age was 47.7±8.6 years old. Mean seniority was 21.5±9.7 years. PQL-35 results were: perception of management support 4.8±1.5; perception of workload 6.2±1.3; intrinsic motivation 7.9±1.1; job disconnection capacity 6.3±2.6; and professional quality of life 5.2±2.1. Gender differences were found in perception of management support (4.5±1.5 in males vs 4.9±1.5 in females; P=.031) and professional quality of life (4.9±2.0 vs 5.3±2.1; p=.044). Depending on the professional group, differences were found in the perception of workload (6.4±1.1 in physicians, 6.3±1.3 in nurses, 5.9±1.6 in non-sanitary professionals, and 5.3±1.2 in support units professionals; Pquality of life in the workers of the Toledo Primary Care Health Area is similar to that of other Spanish Health Areas, even in a time of economic crisis. The intrinsic motivation of the professionals is very high, in contrast with their high perception of workload and their low perception of management support. Copyright © 2014 SECA. Published by Elsevier Espana. All rights reserved.

Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7.

Science.gov (United States)

Coleman, Leon G; Zou, Jian; Crews, Fulton T

2017-01-25

Toll-like receptor (TLR) signaling is emerging as an important component of neurodegeneration. TLR7 senses viral RNA and certain endogenous miRNAs to initiate innate immune responses leading to neurodegeneration. Alcoholism is associated with hippocampal degeneration, with preclinical studies linking ethanol-induced neurodegeneration with central innate immune induction and TLR activation. The endogenous miRNA let-7b binds TLR7 to cause neurodegeneration. TLR7 and other immune markers were assessed in postmortem human hippocampal tissue that was obtained from the New South Wales Tissue Bank. Rat hippocampal-entorhinal cortex (HEC) slice culture was used to assess specific effects of ethanol on TLR7, let-7b, and microvesicles. We report here that hippocampal tissue from postmortem human alcoholic brains shows increased expression of TLR7 and increased microglial activation. Using HEC slice culture, we found that ethanol induces TLR7 and let-7b expression. Ethanol caused TLR7-associated neuroimmune gene induction and initiated the release let-7b in microvesicles (MVs), enhancing TLR7-mediated neurotoxicity. Further, ethanol increased let-7b binding to the danger signaling molecule high mobility group box-1 (HMGB1) in MVs, while reducing let-7 binding to classical chaperone protein argonaute (Ago2). Flow cytometric analysis of MVs from HEC media and analysis of MVs from brain cell culture lines found that microglia were the primary source of let-7b and HMGB1-containing MVs. Our results identify that ethanol induces neuroimmune pathology involving the release of let-7b/HMGB1 complexes in microglia-derived microvesicles. This contributes to hippocampal neurodegeneration and may play a role in the pathology of alcoholism.

Preliminary site description Forsmark area - version 1.2

Energy Technology Data Exchange (ETDEWEB)

Skagius, Kristina [ed.

2005-06-01

The Swedish Nuclear Fuel and Waste Management Company (SKB) is undertaking site characterisation at two different locations, the Forsmark and Simpevarp areas, with the objective of siting a geological repository for spent nuclear fuel. An integrated component in the characterisation work is the development of a site descriptive model that constitutes a description of the site and its regional setting, covering the current state of the geosphere and the biosphere as well as those ongoing natural processes that affect their long-term evolution. The present report documents the site descriptive modelling activities (version 1.2) for the Forsmark area. The overall objectives of the version 1.2 site descriptive modelling are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations. The modelling work is based on primary data, i.e. quality-assured, geoscientific and ecological field data available in the SKB databases SICADA and GIS, available July 31, 2004. The work has been conducted by a project group and associated discipline-specific working groups. The members of the project group represent the disciplines of geology, rock mechanics, thermal properties, hydrogeology, hydrogeochemistry, transport properties and surface ecosystems (including overburden, surface hydrogeochemistry and hydrology). In addition, some group members have specific qualifications of importance in this type of project e.g. expertise in RVS (Rock Visualisation System) modelling, GIS-modelling and in statistical data analysis. The overall strategy to achieve a site description is to develop discipline-specific models by interpretation and analyses of the primary data. The different discipline-specific models are then integrated into a site description. Methodologies for developing the discipline-specific models are documented in

Preliminary site description Forsmark area - version 1.2

International Nuclear Information System (INIS)

Skagius, Kristina

2005-06-01

The Swedish Nuclear Fuel and Waste Management Company (SKB) is undertaking site characterisation at two different locations, the Forsmark and Simpevarp areas, with the objective of siting a geological repository for spent nuclear fuel. An integrated component in the characterisation work is the development of a site descriptive model that constitutes a description of the site and its regional setting, covering the current state of the geosphere and the biosphere as well as those ongoing natural processes that affect their long-term evolution. The present report documents the site descriptive modelling activities (version 1.2) for the Forsmark area. The overall objectives of the version 1.2 site descriptive modelling are to produce and document an integrated description of the site and its regional environments based on the site-specific data available from the initial site investigations and to give recommendations on continued investigations. The modelling work is based on primary data, i.e. quality-assured, geoscientific and ecological field data available in the SKB databases SICADA and GIS, available July 31, 2004. The work has been conducted by a project group and associated discipline-specific working groups. The members of the project group represent the disciplines of geology, rock mechanics, thermal properties, hydrogeology, hydrogeochemistry, transport properties and surface ecosystems (including overburden, surface hydrogeochemistry and hydrology). In addition, some group members have specific qualifications of importance in this type of project e.g. expertise in RVS (Rock Visualisation System) modelling, GIS-modelling and in statistical data analysis. The overall strategy to achieve a site description is to develop discipline-specific models by interpretation and analyses of the primary data. The different discipline-specific models are then integrated into a site description. Methodologies for developing the discipline-specific models are documented in

ASSESSMENT OF SOCIAL AND PSYCHOLOGICAL CONSEQUENCES OF RADIATION DANGER EXPERIENCE AMONG DIFFERENT AGE GROUPS OF THE POPULATION FROM CONTAMINATED AREAS OF RUSSIA

Directory of Open Access Journals (Sweden)

T. A. Marchenko

2012-01-01

Full Text Available The results of evaluation of social-psychological consequences of radiation danger experience among different age groups of the population from contaminated areas of Russia (Oryol, Kaluga, Bryansk, Tula areas among whom the unfavorable emotional and personal changes were registered due to subjective features of perception of radiation threat have been represented (“risk” group. Experimental sample of the research consisted of 1 544 people from Russia. One of the main results of this research is establishment of the fact that adverse emotional and personal changes in connection with subjective features of perception of radiation threat were revealed for 53,9% of respondents of advanced age and more than 20% of respondents of middle and young age from contaminated areas of Russia. Among the respondents from contaminated areas of Belarus, about a third surveyed from each age group get to “risk” group.

A 128 x 128 InGaAs detector array for 1.0-1.7 microns

International Nuclear Information System (INIS)

Olsen, G.; Joshi, A.; Lange, M.; Woodruff, W.; Mykietyn, E.; Gay, D.; Erickson, G.; Ackley, D.; Ban, V.; Staller, C.

1990-01-01

This paper reports on a two-dimensional 128 x 128 detector array for the 1.0 - 1.7 um spectral region that has been demonstrated with indium gallium arsenide (In .53 Ga .47 As). The 30 um square pixels had 60 um spacing in both directions and were designed to be compatible with a two-dimensional Reticon multiplexer. Dark currents below 100 pA, capacitance near 0.1 pF (-5V, room temperature) and quantum efficiencies about 80% (at 1.3 um) were measured. Probe maps of dark current and quantum efficiency are presented along with pixel dropout data and wafer yield which was as high as 99.89% (7 dropouts) in an area of 6528 pixels and 99.37% (103 dropouts) over an entire 128 x 128 pixel region

Principal working group No. 1 on operating experience and human factors (PWG1). Report of the task group on reviewing the activities

International Nuclear Information System (INIS)

2001-02-01

annual meetings of the working group. In addition there has been a large number of workshops, specialists' meetings, and other meetings focused on particular topics. Many reports of a special nature have been published. In 1999 the CSNI has directed some changes in its existing working groups and this has prompted the reexamination of the processes by which PWG-1 discharges its functions. This re-examination is a consequence of the adoption of a Strategic Plan by the Nuclear Energy Agency and some conforming strategic plans by the CSNI and CNRA. In response to CSNI direction, PWG1 formed a Task Group to consider the directions contained in these strategic plans and propose the necessary changes in the working group mandate. As a point of departure the Task Group reviewed the accomplishments of PWG1 since 1994. It was thought that this review might help guide any changes to the group mandate. It was observed that for the most part PWG1 had been discharging its mandate in a careful and efficient manner. The formal guidance from CSNI with respect to review and modification of the PWG1 mandate is contained in the Strategic Plan of the CSNI. One significant aspect of the Strategic Plan was to reassign the Human Factors aspects of PWG1, as embodied in the Extended Task Force (ETF), to a Special Expert Group which will report directly to CSNI. Further, the CSNI decided to embed the Fuel Cycle Task Group within WGOE. Some structural changes characteristic of strategic planning, including prioritization duties, adoption of success criteria (or performance measures), consideration of customer needs, and consideration of the need to review operating experience for possible future research projects were part of the work of the Task Group. This report provides an analysis of recent progress of PWG1, and also proposes changes to the group mandate, in response to the strategic plans of NEA and CSNI. The mandate is quite brief and lists some broad areas of work

Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R and executive function: their interaction with obesity.

Directory of Open Access Journals (Sweden)

Mar Ariza

Full Text Available Obesity is a multifactorial disease caused by the interaction between genotype and environment, and it is considered to be a type of addictive alteration. The A1 allele of the DRD2/ANKK1-TaqIA gene has been associated with addictive disorders, with obesity and with the performance in executive functions. The 7 repeat allele of the DRD4 gene has likewise been associated with the performance in executive functions, as well as with addictive behaviors and impulsivity. Participants were included in the obesity group (N = 42 if their body mass index (BMI was equal to or above 30, and in the lean group (N = 42 if their BMI was below 25. The DRD2/ANKK1-TaqIA and DRD4 VNTR polymorphisms were obtained. All subjects underwent neuropsychological assessment. Eating behavior traits were evaluated. The 'DRD2/ANKK1-TaqIA A1-allele status' had a significant effect on almost all the executive variables, but no significant 'DRD4 7R-allele status' effects were observed for any of the executive variables analyzed. There was a significant 'group' x 'DRD2/ANKK1-TaqIA A1-allele status' interaction effect on LN and 'group' x 'DRD4 7R-allele status' interaction effect on TMT B-A score. Being obese and a carrier of the A1 allele of DRD2/ANKK1-TaqIA or the 7R allele of DRD4 VNTR polymorphisms could confer a weakness as regards the performance of executive functions.

7 CFR 301.89-5 - Movement of regulated articles from regulated areas.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Movement of regulated articles from regulated areas. 301.89-5 Section 301.89-5 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL... § 301.89-5 Movement of regulated articles from regulated areas. (a) Any regulated article may be moved...

1,8-Dihydroxy-2,4,5,7-tetranitro-9,10-anthraquinone

Directory of Open Access Journals (Sweden)

Mahsa Armaghan

2010-05-01

Full Text Available The ring system in the title compound, C14H4N4O12, is essentially planar (r.m.s. deviation of the carbon atoms = 0.085 Å; the two hydroxy groups form intramolecular hydrogen bonds to the same carbonyl O atom. The nitro groups are twisted with respect to the mean plane of the ring system by 74.3 (1 (1-nitro, 42.3 (3 (3-nitro, 45.7 (3 (6-nitro and 66.9 (1° (8-nitro.

Design of a MCoTI-Based Cyclotide with Angiotensin (1-7-Like Activity

Directory of Open Access Journals (Sweden)

Teshome Aboye

2016-01-01

Full Text Available We report for the first time the design and synthesis of a novel cyclotide able to activate the unique receptor of angiotensin (1-7 (AT1-7, the MAS1 receptor. This was accomplished by grafting an AT1-7 peptide analog onto loop 6 of cyclotide MCoTI-I using isopeptide bonds to preserve the α-amino and C-terminal carboxylate groups of AT1-7, which are required for activity. The resulting cyclotide construct was able to adopt a cyclotide-like conformation and showed similar activity to that of AT1-7. This cyclotide also showed high stability in human serum thereby providing a promising lead compound for the design of a novel type of peptide-based in the treatment of cancer and myocardial infarction.

Investigations of groundwater system and simulation of regional groundwater flow for North Penn Area 7 Superfund site, Montgomery County, Pennsylvania

Science.gov (United States)

Senior, Lisa A.; Goode, Daniel J.

2013-01-01

Groundwater in the vicinity of several industrial facilities in Upper Gwynedd Township and vicinity, Montgomery County, in southeast Pennsylvania has been shown to be contaminated with volatile organic compounds (VOCs), the most common of which is the solvent trichloroethylene (TCE). The 2-square-mile area was placed on the National Priorities List as the North Penn Area 7 Superfund site by the U.S. Environmental Protection Agency (USEPA) in 1989. The U.S. Geological Survey (USGS) conducted geophysical logging, aquifer testing, and water-level monitoring, and measured streamflows in and near North Penn Area 7 from fall 2000 through fall 2006 in a technical assistance study for the USEPA to develop an understanding of the hydrogeologic framework in the area as part of the USEPA Remedial Investigation. In addition, the USGS developed a groundwater-flow computer model based on the hydrogeologic framework to simulate regional groundwater flow and to estimate directions of groundwater flow and pathways of groundwater contaminants. The study area is underlain by Triassic- and Jurassic-age sandstones and shales of the Lockatong Formation and Brunswick Group in the Mesozoic Newark Basin. Regionally, these rocks strike northeast and dip to the northwest. The sequence of rocks form a fractured-sedimentary-rock aquifer that acts as a set of confined to partially confined layers of differing permeabilities. Depth to competent bedrock typically is less than 20 ft below land surface. The aquifer layers are recharged locally by precipitation and discharge locally to streams. The general configuration of the potentiometric surface in the aquifer is similar to topography, except in areas affected by pumping. The headwaters of Wissahickon Creek are nearby, and the stream flows southwest, parallel to strike, to bisect North Penn Area 7. Groundwater is pumped in the vicinity of North Penn Area 7 for industrial use, public supply, and residential supply. Results of field investigations

7 CFR 330.301 - Stone and quarry products from certain areas in Canada.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Stone and quarry products from certain areas in Canada... § 330.301 Stone and quarry products from certain areas in Canada. Stone and quarry products from areas in Canada infested with the gypsy moth may be moved from Canada into or through the United States...

RCRA Facility Investigation report for Waste Area Grouping 6 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 3. Appendixes 1 through 8

Energy Technology Data Exchange (ETDEWEB)

None

1991-09-01

This report presents compiled information concerning a facility investigation of waste area group 6(WAG-6), of the solid waste management units (SWMU'S) at Oak Ridge National Laboratory (ORNL). The WAG is a shallow ground disposal area for low-level radioactive wastes and chemical wastes. The report contains information on hydrogeological data, contaminant characterization, radionuclide concentrations, risk assessment from doses to humans and animals and associated cancer risks, exposure via food chains, and historical data. (CBS)

Grouping of body areas affected in traffic accidents. A cohort study.

Science.gov (United States)

León, Alba Luz; Ascuntar-Tello, Johana; Valderrama-Molina, Carlos Oliver; Giraldo, Nelson Darío; Constaín, Alfredo; Puerta, Andrés; Restrepo, Camilo; Jaimes, Fabián

2018-03-01

Traffic accidents are considered a public health problem and, according to the World Health Organization, currently is the eighth cause of death in the world. Specifically, pedestrians, cyclists and motorcyclists contribute half of the fatalities. Adequate clinical management in accordance with aggregation patterns of the body areas involved, as well as the characteristics of the accident, will help to reduce mortality and disability in this population. Secondary data analysis of a cohort of patients involved in traffic accidents and admitted to the emergency room (ER) of a high complexity hospital in Medellín, Colombia. They were over 15 years of age, had two or more injuries in different areas of the body and had a hospital stay of more than 24 h after admission. A cluster analysis was performed, using Ward's method and the linfinity similarity measure, to obtain clusters of body areas most commonly affected depending on the type of vehicle and the type of victim. Among 2445 patients with traffic accidents, 34% (n = 836) were admitted into the Intensive Care Unit (ICU) and the overall hospital mortality rate was 8% (n = 201). More than 50% of the patients were motorcycle riders but mortality was higher in pedestrian-car accidents (16%, n = 34). The clusters show efficient performance to separate the population depending on the severity of their injuries. Pedestrians had the highest mortality after having accidents with cars and they also had the highest number of body parts clustered, mainly on head and abdomen areas. Exploring the cluster patterns of injuries and body areas affected in traffic accidents allow to establish anatomical groups defined by the type of accident and the type of vehicle. This classification system will accelerate and prioritize ER-care for these population groups, helping to provide better health care services and to rationalize available resources.

Comparative study and grouping of nonstructural (NS1)proteins of influenza A viruses by the method of oligopeptide mapping

International Nuclear Information System (INIS)

Sokolov, B.P.; Rudneva, I.A.; Zhdanov, V.M.

1983-01-01

Oligopeptide mapping of 35 S-methionine labeled non-stuctural (NS1) proteins of 23 influenza A virus strains showed the presence of both common and variable oligopeptides. Analysis of the oligopeptide maps revealed at least four groups of NS1 proteins. The first group includes NS1 proteins of several human H1N1 influenza viruses (that were designated as H0N1 according to the old classification). The second group is composed of NS1 proteins of H1N1 and H2N2 viruses. The third group includes NS1 proteins of H3N2 human influenza viruses. The fourth group is composed of NS1 proteins of five avian influenza viruses and an equine (H3N8) influenza virus. Two animal influenza viruses A/equi/Prague/56 (H7N7) and A/duck/England/56 (H11N6) contain NS1 proteins that belong to the second group. (Author)

Numerical simulations of air–water cap-bubbly flows using two-group interfacial area transport equation

International Nuclear Information System (INIS)

Wang, Xia; Sun, Xiaodong

2014-01-01

Highlights: • Two-group interfacial area transport equation was implemented into a three-field two-fluid model in Fluent. • Numerical model was developed for cap-bubbly flows in a narrow rectangular flow channel. • Numerical simulations were performed for cap-bubbly flows with uniform void inlets and with central peaked void inlets. • Code simulations showed a significant improve over the conventional two-fluid model. - Abstract: Knowledge of cap-bubbly flows is of great interest due to its role in understanding of the flow regime transition from bubbly to slug or churn-turbulent flows. One of the key characteristics of such flows is the existence of bubbles in different sizes and shapes associated with their distinctive dynamic natures. This important feature is, however, generally not well captured by many available two-phase flow modeling approaches. In this study, a modified two-fluid model, namely a three-field, two-fluid model, is proposed. In this model, bubbles are categorized into two groups, i.e., spherical/distorted bubbles as Group-1 while cap/churn-turbulent bubbles as Group-2. A two-group interfacial area transport equation (IATE) is implemented to describe dynamic changes of interfacial structure in each bubble group, resulting from intra- and inter-group interactions and phase changes due to evaporation and condensation. Attention is also paid to appropriate constitutive relations of the interfacial transfers due to mechanical and thermal non-equilibrium between the different fields. The proposed three-field, two-fluid model is used to predict the phase distributions of adiabatic air–water flows in a confined rectangular duct. Good agreement between the simulation results from the proposed model and relevant experimental data indicates that the proposed model is promising as an improved computational tool for two-phase cap-bubbly flow simulations in rectangular flow ducts

[Two compartment model of body composition and abdominal fat area in postmenopausal women - pilot study].

Science.gov (United States)

Milewska, Magdalena; Mioduszewska, Milena; Pańczyk, Mariusz; Kucharska, Alicja; Sińska, Beata; Dąbrowska-Bender, Marta; Michota-Katulska, Ewa; Zegan, Magdalena; Szabla, Anna

2016-01-01

Both menopausal period and aging have influence on body composition, increase of total body fat and visceral fat in particular. We should be aware that changes in body composition, mainly fat translocation to abdominal region, can occur without significant changes in body weight. Therefore quantitative abdominal fat assessment should be our aim. Body composition analysis based on two compartment model and abdominal fat area assessment in cross section. Subjects in postmenopausal period (41 women) were recruited for this study and divided into 2 groups: group 1 - women aged 45-56 years and group 2 - women aged 57-79 years. Body composition analysis and abdominal fat area assessment were conducted by using bioelectrical impedance method with BioScan 920 (Maltron int.) accordingly with standardized procedure. Women in early postmenopausal stage (Group 1) had statistically significant lower total body fat percentage in comparison with women in late postmenopausal period (Group 2) (41.09 ± 7.72% vs. 50.7 ± 9.88%, p=0.0021). Also women in group 1 were characterized by significant lower visceral fat area (VAT) as well as subcutaneous fat area (SAT) in comparison with group 2 (respectively VAT 119.25 ± 30.09 cm2 vs. 199.36 ± 87.38 cm2, p=0.0011; SAT 175.19 ±57.67 cm2 vs. 223.4±74.29 cm2, p=0.0336). According to VAT criteria (>120 cm2), 44% of women in group 1 and 80% in group 2 had excess of visceral fat. Both total body fat and intra-abdominal fat increased with age, independently of weight changes.

Mesenchymal Stem Cells Mitigate Cirrhosis through BMP7

Directory of Open Access Journals (Sweden)

Bing Li

2015-01-01

Full Text Available Background/Aims: Transplantation of mesenchymal stem cells (MSCs has therapeutic effects on various diseases, while its effect on developing cirrhosis as well as the underlying mechanism remained largely unknown. Methods: Twenty C57BL/6 mice were randomly separated into 2 groups of ten each. One group received transplantation of MSCs, while the other group received saline as control. The mice then received intraperitoneal injection of carbon tetrachloride (CCl4 twice per week for 8 weeks to develop cirrhosis. After another 4 weeks, the levels of cirrhosis in these mice were evaluated by liver fibrosis area, portal pressure, sodium balance and excretion. Transcripts of transforming growth factor β 1 (TGFβ1 and bone morphogenic protein 7 (BMP7 in the mouse livers were quantified by RT-qPCR. BMP7-depleted MSCs were prepared and applied in this model, and compared to MSCs. Results: Liver fibrosis, portal hypertension and sodium retention that were developed by CCl4, were all significantly alleviated by MSCs transplantation, which decreased TGFβ1 levels and increased BMP7 levels in the injured liver. MSCs were found to express extremely high levels of BMP7. Knockdown of BMP7 in MSCs completely abolished the protective effect of MSCs against CCl4-induced cirrhosis. Conclusions: MSCs mitigate cirrhosis through their production of BMP7 against the fibrogenic effect of TGFβ1 in the injured liver.

M-theory on eight-manifolds revisited: N = 1 supersymmetry and generalized Spin(7) structures

International Nuclear Information System (INIS)

Tsimpis, Dimitrios

2006-01-01

The requirement of N = 1 supersymmetry for M-theory backgrounds of the form of a warped product M x w X, where X is an eight-manifold and M is three-dimensional Minkowski or AdS space, implies the existence of a nowhere-vanishing Majorana spinor ξ on X. ξ lifts to a nowhere-vanishing spinor on the auxiliary nine-manifold Y: = X x S 1 , where S 1 is a circle of constant radius, implying the reduction of the structure group of Y to Spin(7). In general, however, there is no reduction of the structure group of X itself. This situation can be described in the language of generalized Spin(7) structures, defined in terms of certain spinors of Spin(TY+T*Y). We express the condition for N = 1 supersymmetry in terms of differential equations for these spinors. In an equivalent formulation, working locally in the vicinity of any point in X in terms of a 'preferred' Spin(7) structure, we show that the requirement of N = 1 supersymmetry amounts to solving for the intrinsic torsion and all irreducible flux components, except for the one lying in the 27 of Spin(7), in terms of the warp factor and a one-form L on X (not necessarily nowhere-vanishing) constructed as a ξ bilinear; in addition, L is constrained to satisfy a pair of differential equations. The formalism based on the group Spin(7) is the most suitable language in which to describe supersymmetric compactifications on eight-manifolds of Spin(7) structure, and/or small-flux perturbations around supersymmetric compactifications on manifolds of Spin(7) holonomy

Elevated levels of von Willebrand factor and high mobility group box 1 (HMGB1) are associated with disease severity and clinical outcome of scrub typhus.

Science.gov (United States)

Chen, Hongliu; Ning, Zong; Qiu, Ying; Liao, Yuanli; Chang, Haihua; Ai, Yuanyuan; Wei, Yinghua; Deng, Yiming; Shen, Ying

2017-08-01

This study aimed to investigate whether von Willebrand factor (vWF) and high mobility group box 1 (HMGB1) are associated with the severity and clinical outcome of scrub typhus and to seek novel biomarkers for surveillance and prediction of the prognosis of this infection. Serum concentrations of vWF and HMGB1 were measured twice by ELISA for scrub typhus patients (n=103), once prior to doxycycline therapy and then on day 7 of doxycycline therapy; concentrations were measured once for healthy controls (n=32). Among the total 103 patients enrolled, 38 had disease complicated by multiple organ dysfunction syndrome (MODS). Serum concentrations of vWF and HMGB1 were significantly higher in all the patients than in the healthy controls, both prior to doxycycline treatment and on day 7 of doxycycline treatment (pscrub typhus (area under the curve (AUC)=0.864, p=0.001, and AUC=0.862, p=0.001, respectively). Elevated levels of vWF and HMGB1 are associated with the severity and clinical outcome of scrub typhus. These represent possible new biomarkers for use in the assessment and prognostic prediction of this infection. Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Site investigation report for Waste Area Grouping 4 at Oak Ridge National Laboratory. Volume 1, Text: Environmental Restoration Program

International Nuclear Information System (INIS)

1995-08-01

Waste Area Grouping (WAG) 4 is one of 17 WAGs within and associated with Oak Ridge National Laboratory (ORNL). WAG 4 is located south of the main facility along Lagoon Road. WAG 4 consists of three separate areas: Solid Waste Storage Area (SWSA) 4, a shallow-land-burial ground containing radioactive and potentially hazardous wastes; an experimental Pilot Pit Area, which includes a pilot-scale testing pit; and sections of two abandoned underground pipelines used for transporting liquid, low-level, radioactive waste. SWSA 4 is the largest site at WAG 4, covering approximately 23 acres. In the 1950s, SWSA 4 received a variety of low- and high-activity wastes, including transuranic wastes, all buried in trenches and auger holes. Recent surface water data, collected during monitoring of the tributary to White Oak Creek as part of WAG 2 investigations as well as during previous studies conducted at WAG 4, indicate that a significant amount of 90 Sr is being released from the old burial trenches in SWSA 4. This release represents a significant portion of the ORNL off-site risk (DOE 1993). With recent corrective measures the proportion of the release has increased in 1995. A detailed discussion of the site history and previous investigations is presented in the WAG 4 Preliminary Assessment Report, ORNL/ER-271 (Energy Systems 1994b). In an effort to control the sources of the 90 Sr release and to reduce the off-site risk, a site investigation was initiated to pinpoint those trenches that are the most prominent 90 Sr sources

7 CFR 767.1 - Introduction.

Science.gov (United States)

2010-01-01

... SPECIAL PROGRAMS INVENTORY PROPERTY MANAGEMENT Overview § 767.1 Introduction. (a) Purpose. This part... 7 Agriculture 7 2010-01-01 2010-01-01 false Introduction. 767.1 Section 767.1 Agriculture... financial interest. ...

Cs_7Sm_1_1[TeO_3]_1_2Cl_1_6 and Rb_7Nd_1_1[TeO_3]_1_2Br_1_6, the new tellurite halides of the tetragonal Rb_6LiNd_1_1[SeO_3]_1_2Cl_1_6 structure type

International Nuclear Information System (INIS)

Charkin, Dmitri O.; Black, Cameron; Downie, Lewis J.; Sklovsky, Dmitry E.; Berdonosov, Peter S.; Olenev, Andrei V.; Zhou, Wuzong; Lightfoot, Philip; Dolgikh, Valery A.

2015-01-01

Two new rare-earth – alkali – tellurium oxide halides were synthesized by a salt flux technique and characterized by single-crystal X-ray diffraction. The structures of the new compounds Cs_7Sm_1_1[TeO_3]_1_2Cl_1_6 (I) and Rb_7Nd_1_1[TeO_3]_1_2Br_1_6 (II) (both tetragonal, space group I4/mcm) correspond to the sequence of [MLn_1_1(TeO_3)_1_2] and [M_6X_1_6] layers and bear very strong similarities to those of known selenite analogs. We discuss the trends in similarities and differences in compositions and structural details between the Se and Te compounds; more members of the family are predicted. - Graphical abstract: Two new rare-earth – alkali – tellurium oxide halides were predicted and synthesized. - Highlights: • Two new rare-earth – alkali – tellurium oxide halides were synthesized. • They adopt slab structure of rare earth-tellurium-oxygen and CsCl-like slabs. • The Br-based CsCl-like slabs have been observed first in this layered family.

1 CFR 18.7 - Signature.

Science.gov (United States)

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false Signature. 18.7 Section 18.7 General Provisions... PREPARATION AND TRANSMITTAL OF DOCUMENTS GENERALLY § 18.7 Signature. The original and each duplicate original... stamped beneath the signature. Initialed or impressed signatures will not be accepted. Documents submitted...

Evaluation of the Surface Treatment on Bone Healing in a Transmucosal 1-mm Area of Implant Abutment: An Experimental Study in the Rabbit Tibia.

Science.gov (United States)

Gehrke, Sergio Alexandre; da Silva Neto, Ulisses Tavares

2016-06-01

The objective of the present study was to investigate the effect on bone tissue healing patterns in 1-mm area treated in the transmucosal surface of the abutment in the tibia of rabbits. Forty-six abutments were divided into two groups: control group (CG) with 14 abutments with smooth surface and experimental group (EG) with 32 abutments presenting a 1-mm area of the transmucosal surface treated through sandblasting with microparticles of titanium oxide followed by acid etching. Five samples of each group were analyzed using an optical laser profilometer for surface roughness characterization. Thirty-six Morse taper implants (3.5 mm in diameter and 7 mm in length) were inserted 1.5 mm subcrestal into the tibiae of nine rabbits. The implants were removed after 8, 10, and 12 weeks for histological analysis. The histological slides were prepared and analyzed qualitatively in relation to the new bone at the interface bone-abutment and quantitatively, in relation to bone height from the base of the implant. These data were computed and statistically compared inside the groups using analysis of variance and the U-test between groups for same time. Both groups exhibited bone growth in the direction and over the surface of the abutments, with good healing. However, the EG group showed an increased height of bone formation in the crestal direction, and highly significant differences were observed (p abutment with treatment of the surface facilitated the maintenance of bone height around the abutment compared with the same abutment with the totally smooth surface. © 2015 Wiley Periodicals, Inc.

The Remediation of Hanford's Last Low-Level Waste Burial Grounds in the 300 Area: 618-7 and 618-1

International Nuclear Information System (INIS)

Haass, M.J.

2009-01-01

Under the U.S. Department of Energy's (DOE) River Corridor Closure Project, Washington Closure Hanford (WCH) has completed remediation of more than seven low-level waste (LLW) burial grounds in the 300 Area of the Hanford Site. The records of decision for the burial grounds required excavation, characterization, and transport of contaminated material to a Resource Conservation and Recovery Act of 1976-compliant hazardous waste landfill. This paper discusses the challenges and lessons learned from remediating the last two major burial grounds in the 300 Area: 618-7 and 618-1. The 618-7 Burial Ground was in operation from 1960 through 1973, during which it received waste from the production of Zircaloy (zirconium alloy) jacketed metallic uranium fuel rods and thoria targets for the production of uranium-233. Its major remediation challenges included the recovery, characterization, and disposal of 550 drums and disposal of two compressed gas cylinders that were suspected to contain highly toxic chemicals. Approximately 100 of the drums contained Zircaloy metal turnings that could be pyrophoric under certain conditions. Remediation activities were completed in December 2008. The 618-1 Burial Ground was in operation from 1945 (i.e., the beginning of Hanford operations) through 1951. It received waste from 300 Area laboratories that conducted experimental work associated with World War II and Cold War era processes for fuel fabrication and the production of plutonium. Some of the wastes were associated with highly radioactive irradiated material. Remediation of this burial ground is still in progress and is expected to be completed by June 2009. Information presented in this paper will be an aid to those involved in the planning, design, and remediation of burial grounds located on the DOE complex. (authors) Remediation of the 618-7 Burial Ground was completed in December 2008; the 618-1 Burial Ground is proceeding without incident and is expected to be completed in June

CYP7B1

DEFF Research Database (Denmark)

Roos, P; Svenstrup, K; Danielsen, E R

2014-01-01

UNLABELLED: The SPG5A subtype of Hereditary Spastic Paraplegia (HSP) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the CYP7B1 gene, which encodes a steroid cytochrome P450 7α-hydroxylase. This enzyme provides the primary metabolic route for neurosteroids. Clinica......UNLABELLED: The SPG5A subtype of Hereditary Spastic Paraplegia (HSP) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the CYP7B1 gene, which encodes a steroid cytochrome P450 7α-hydroxylase. This enzyme provides the primary metabolic route for neurosteroids.......945_947 dupGGC p.A316AA). CONCLUSION: SPG5A could be characterized as a predominantly pure HSP. MRS showing elevated mI/Cr ratio in the white matter may be indicative of SPG5A....

Data Quality Objectives Summary Report for the 100-FR-1, 100-FR-2, 100-HR-1,100-KR-1, and 100-KR-2 Group 4 Waste Sites

International Nuclear Information System (INIS)

1997-10-01

The 100-FR-1, 100-FR-2, 100-HR-1, 100-KR-1, and 100-KR-2 Group 4 waste sites will be the fourth set of Hanford 100 Area sites to undergo remediation. Like the sites in Groups 1, 2,and 3, the majority of Group 4 sties are considered high priority because of the contaminants present and their proximity to the Columbia River. the data quality objectives process,summarized in this document, is a U.S. Environmental Protection Agency approach for addressing data collecting and decision-making issues that are part of an environmental remediation project. The basic cleanup assumptions made in the Group 1, 2, and 3 designs are retained for the Group 4 design. As was the case with Group 3, the most significant difference between this DQO Summary Report and the Group 1 and 2 DQO Summary Reports is the data gaps that exist for specific Group 4 waste sites. These data gaps affect the approach to waste profiling and are the principal focus of the Group 4 DQO process

Fission-track ages of the Tokai Group and associate formations in the east coast areas of Ise Bay and their significance in geohistory

International Nuclear Information System (INIS)

Makinouchi, Takeshi; Danhara, Toru; Isoda, Kunitoshi.

1983-01-01

Fission-track ages of volcanic ash layers within the Tokai Group and associate formations in the east coast areas of Ise Bay are obtained by grain-by-grain method with which individual ages for the respective zircon grains are measured. They are as follows; 1) a volcanic ash layer in the Karayama Formation (tentative age: 1.9 +- 0.4 Ma). Among the zircon grains in this layer, essential ones occupy only 1 per cent, and the others are accidental. 2) Ohtani volcanic ash layer (4.3 +- 0.6 Ma). 3) Kosugaya volcanic ash layer (4.0 +- 0.5 Ma). 4) Kaminoma volcanic ash layer (5.3 +- 0.4 Ma). 5) A volcanic ash layer in the Toyoura Formation seems to be older than 10 Ma. 6) Zircon grains in the Kofu volcanic ash layer (Tokai Group) include two types of spontaneous namely track, clear and vague ones. The latter vague tracks are shorter and thiner, and seem to suffer thermal annealing. The ages obtained have clarified the following Points; a) The tentative age, 1.9 Ma, of the ''Karayama'' volcanic ash layer suggests the existence of unknown Plio-Pleistocene sediment in the Nagoya area. b) The sedimentary basin of Lake Tokai was formed in the latest Miocene, about 6.5 Ma. Generation of the basin coincides approximately with the stage of synchronous and abrupt change in sedimentation rate in sedimentary basins on the Pacific side of central and southern Japan. c) The Tokai Group in Chita (Tokoname Group) intercalates the Gilbert/Epoch 5 boundary in the paleomagnetic chronology in the middle horizon of the group. d) Average rate of sedimentation is about 1 m/10 4 yrs in the marginal areas of the basin, and 3-5 m/10 4 yrs in the central areas. (author)

Proton magnetic resonance spectroscopy ((1H-MRS reveals geniculocalcarine and striate area degeneration in primary glaucoma.

Directory of Open Access Journals (Sweden)

Yan Zhang

Full Text Available BACKGROUND: Glaucoma is a collection of neurodegenerative diseases that affect both the retina and the central visual pathway. We investigated whether metabolites' concentrations changed in the geniculocalcarine (GCT and the striate area of occipital lobe by proton magnetic resonance spectroscopy ((1H-MRS, suggesting neurodegeneration of the central visual pathway in primary glaucoma. METHODOLOGY/PRINCIPAL FINDINGS: 20 patients with glaucoma in both eyes were paired with 20 healthy volunteers in same gender and an age difference less than 3 years. All the participants were examined by MR imaging including T1 Flair, T2 FSE and (1H-MRS. The T1 intensity and T2 intensity of their GCTs and striate areas were measured. The ratio of N-acetylaspartate (NAA/Creatine (Cr, Choline (Cho/Cr, glutamine and glutamate (Glx/Cr were derived by multi-voxels (1H-MRS in the GCT and the striate area of each brain hemisphere. The T1 intensity and T2 intensity had no difference between the groups. Significant decreases in NAA/Cr and Cho/Cr but no difference in Glx/Cr was found between the groups in both the GCT and the striate area. CONCLUSIONS/SIGNIFICANCE: Primary glaucoma affects metabolites' concentrations in the GCT and the striate area suggesting there is ongoing neurodegenerative process.

7 CFR 767.202 - Real estate inventory property located in special hazard areas.

Science.gov (United States)

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Real estate inventory property located in special...) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS INVENTORY PROPERTY MANAGEMENT Real Estate Property With Important Resources or Located in Special Hazard Areas § 767.202 Real estate...

Angiotensin-(1–7 inhibits inflammation and oxidative stress to relieve lung injury induced by chronic intermittent hypoxia in rats

Directory of Open Access Journals (Sweden)

W. Lu

2016-01-01

Full Text Available Obstructive sleep apnea is associated with inflammation and oxidative stress in lung tissues and can lead to metabolic abnormalities. We investigated the effects of angiotensin1–7 [Ang-(1–7] on lung injury in rats induced by chronic intermittent hypoxia (CIH. We randomly assigned 32 male Sprague-Dawley rats (180–200 g to normoxia control (NC, CIH-untreated (uCIH, Ang-(1–7-treated normoxia control (N-A, and Ang-(1–7-treated CIH (CIH-A groups. Oxidative stress biomarkers were measured in lung tissues, and expression of NADPH oxidase 4 (Nox4 and Nox subunits (p22phox, and p47phox was determined by Western blot and reverse transcription-polymerase chain reaction. Pulmonary pathological changes were more evident in the uCIH group than in the other groups. Enzyme-linked immunosorbent assays and immunohistochemical staining showed that inflammatory factor concentrations in serum and lung tissues in the uCIH group were significantly higher than those in the NC and N-A groups. Expression of inflammatory factors was significantly higher in the CIH-A group than in the NC and N-A groups, but was lower than in the uCIH group (P<0.01. Oxidative stress was markedly higher in the uCIH group than in the NC and N-A groups. Expression of Nox4 and its subunits was also increased in the uCIH group. These changes were attenuated upon Ang-(1–7 treatment. In summary, treatment with Ang-(1-7 reversed signs of CIH-induced lung injury via inhibition of inflammation and oxidative stress.

Distributed Group-Based Mobility Management Scheme in Wireless Body Area Networks

Directory of Open Access Journals (Sweden)

Moneeb Gohar

2017-01-01

Full Text Available For group-based mobility management in 6LoWPAN-based wireless body area networks (WBAN, some schemes using the Proxy Mobile IPv6 (PMIP have been proposed. However, the existing PMIP-based mobility schemes tend to induce large registration delay and handover delay. To overcome such limitations, we propose a new distributed group-based mobility management scheme, in which the Local Mobility Anchor (LMA function is implemented by each Mobile Access Gateway (MAG and the handover operation is performed between two neighboring MAGs without the help of LMA. Besides, each MAG maintains the information of the group of mobile sensors and aggregates the Authentication-Authorization-Accounting (AAA query messages for a group of mobile sensors as a “single” message to decrease the control overhead. By numerical analysis, it is shown that the proposed scheme can reduce the registration and handover delays, compared to the existing PMIP-based mobility schemes.

7 CFR 801.1 - Applicability.

Science.gov (United States)

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Applicability. 801.1 Section 801.1 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD... FOR GRAIN INSPECTION EQUIPMENT § 801.1 Applicability. The requirements set forth in this part 801...

Magneto-Sensitive Adsorbents Modified by Functional Nitrogen-Containing Groups

Science.gov (United States)

Melnyk, Inna V.; Gdula, Karolina; Dąbrowski, Andrzej; Zub, Yuriy L.

2016-02-01

In order to obtain amino-functionalized silica materials with magnetic core, one-step synthesis was carried out. Several materials, differ in number and structure of amino groups, were synthesized on the basis of sol-gel method. The synthesized materials were examined by several analytical techniques. The presence and content of amino groups were measured by using Diffuse Reflectance Infrared Fourier Transform (DRIFT) spectroscopy and acid-base titration, respectively. Specific surface areas were measured by nitrogen/adsorption desorption isotherms. It was proved that sol-gel approach leads to obtain materials with high content of amino groups built into their surfaces (in the range 1.6-2.7 mmol/g). As-obtained materials were tested as potential adsorbents for copper(II) ions. The received maximum adsorption capacities were in the range 0.4-0.7 mmol/g.

7 CFR 701.1 - Administration.

Science.gov (United States)

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 701.1 Section 701.1 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... ADMINISTERED UNDER THIS PART § 701.1 Administration. (a) Subject to the availability of funds, this part...

Group theoretical treatment of the low-temperature phase transition of the Cd6Ca 1/1-cubic approximant

International Nuclear Information System (INIS)

Tamura, R.; Shibata, K.; Nishimoto, K.; Takeuchi, S.; Edagawa, K.; Saitoh, K.; Isobe, M.; Ueda, Y.

2005-01-01

An antiparallel orientational transition is reported for an intermetallic compound, i.e., Cd 6 Ca crystal, which is a 1/1-1/1-1/1 crystalline approximant to the icosahedral quasicrystal Cd 5.7 Ca. A group theoretical analysis based on the Landau theory predicts that the space group of the low-temperature phase is either C2/c or C2/m, in good agreement with the observations. Accordingly, two types of orientational orderings of Cd 4 tetrahedra, which are located in the center of icosahedral clusters, may occur below 100 K: In both cases, the Cd 4 tetrahedra are orientationally ordered in an antiparallel fashion along the [110] direction of the high temperature body-centered-cubic phase. Such a transition in a metal is reminiscent of orientational transitions in molecular solids

2005 Annual Operations Report for INTEC Operable Unit 3-13, Group 1, Tank Farm Interim Action

International Nuclear Information System (INIS)

D. Shanklin

2006-01-01

This annual operations report describes the requirements followed and activities conducted to inspect, monitor, and maintain the items installed during performance of the Waste Area Group 3, Operable Unit 3-13, Group 1, Tank Farm Interim Action, at the Idaho Nuclear Technology and Engineering Center. This report describes inspection and monitoring activities for the surface-sealed areas within the tank farm, concrete-lined ditches and culverts in and around the tank farm, the lift station, and the lined evaporation pond. These activities are intended to assure that the interim action is functioning adequately to meet the objectives stated in the Operable Unit 3-13, Record of Decision for the Group 1, Tank Farm Interim Action, (DOE/ID-10660) and as amended by the agreement to resolve dispute, which was effective in February 2003

Electronic and ionization spectra of 1,1-diamino-2,2-dinitroethylene, FOX-7.

Science.gov (United States)

Borges, Itamar

2014-03-01

Singlet, triplet and ionized states of the energetic molecule 1,1-diamino-2,2-dinitroethylene, known as FOX-7 or DADNE, were investigated using the symmetry-adapted-cluster configuration interaction (SAC-CI) ab initio wave function. The 20 computed singlet transitions, with 2 exceptions, were bright. The most intense singlet transitions were of the n₀→π type-typical of molecules having nitro groups. Fast intersystem crossing (ISC) from the 1¹A, 2¹A and 8¹A bright singlet transitions is possible. Other feasible ISC processes are discussed. The computed singlet and ionization spectra have similar features when compared to nitramide and N,N-dimethylnitramine molecules, which have only a nitro group. The ionization energies of the first 20 states have differences in comparison with Koopmans' energy values that can reach 3 eV. Moreover, the character of the first ionized states, dominated by single ionizations, is not the same when compared with the character resulting from application of Koopmans' theorem.

Waste area Grouping 2 Phase I task data report: Human health risk assessment

International Nuclear Information System (INIS)

Purucker, S.T.; Douthat, D.M.

1996-06-01

This report is one of five reports issued in 1996 that provide follow- up information to the Phase 1 Remedial Investigation (RI) Report for Waste Area Grouping (WAG) 2 at Oak Ridge National Laboratory (ORNL). The five reports address areas of concern that could cause potential human health risk and ecological risk within WAG2 at ORNL. The purpose of this report is to present a summary of the human health risk assessment results based on the data collected for the WAG 2 Phase 1 RI. Estimates of risk are provided based on measured concentrations in the surface water, floodplain soil, and sediment of White Oak Creek, Melton Branch, and their tributaries. The human health risk assessment methodology used in this risk assessment is based on Risk Assessment Guidance for Superfund (RAGS). First, the data for the different media are elevated to determine usability for risk assessment. Second, through the process of selecting chemicals of potential concern (COPCs), contaminants to be considered in the risk assessment are identified for each assessment of exposure potential is performed, and exposure pathways are identified. Subsequently, exposure is estimated quantitatively, and the toxicity of each of the COPCs is determined. The results of these analyses are combined and summarized in a risk characterization

Characterization, Leaching, and Filtration Testing for Tributyl Phosphate (TBP, Group 7) Actual Waste Sample Composites

Energy Technology Data Exchange (ETDEWEB)

Edwards, Matthew K.; Billing, Justin M.; Blanchard, David L.; Buck, Edgar C.; Casella, Amanda J.; Casella, Andrew M.; Crum, J. V.; Daniel, Richard C.; Draper, Kathryn E.; Fiskum, Sandra K.; Jagoda, Lynette K.; Jenson, Evan D.; Kozelisky, Anne E.; MacFarlan, Paul J.; Peterson, Reid A.; Shimskey, Rick W.; Snow, Lanee A.; Swoboda, Robert G.

2009-03-09

.A testing program evaluating actual tank waste was developed in response to Task 4 from the M-12 External Flowsheet Review Team (EFRT) issue response plan. The bulk water-insoluble solid wastes that are anticipated to be delivered to the Waste Treatment and Immobilization Plant (WTP) were identified according to type such that the actual waste testing could be targeted to the relevant categories. Eight broad waste groupings were defined. Samples available from the 222S archive were identified and obtained for testing. The actual waste-testing program included homogenizing the samples by group, characterizing the solids and aqueous phases, and performing parametric leaching tests. The tributyl phosphate sludge (TBP, Group 7) is the subject of this report. The Group 7 waste was anticipated to be high in phosphorus as well as aluminum in the form of gibbsite. Both are believed to exist in sufficient quantities in the Group 7 waste to address leaching behavior. Thus, the focus of the Group 7 testing was on the removal of both P and Al. The waste-type definition, archived sample conditions, homogenization activities, characterization (physical, chemical, radioisotope, and crystal habit), and caustic leaching behavior as functions of time, temperature, and hydroxide concentration are discussed in this report. Testing was conducted according to TP-RPP-WTP-467.

Rat-liver cholesterol 7α-hydroxylase. Pt. 1

International Nuclear Information System (INIS)

Cantfort, J. van; Renson, J.; Gielen, J.

1975-01-01

A new assay is described to measure the activity of cholesterol 7α-hydroxylase and compared to the conventional 14 C method used by other investigators. This method is based on the mechanism of the enzymic hydroxylation, i.e. a direct and stereospecific substitution of the 7α-hydrogen by a hydroxyl group. [7α- 3 H]cholesterol is incubated at 37 0 C and in the presence of molecular O 2 , in a medium buffered by potassium phosphate at pH 7.4 and containing liver microsomes (or 9,000 x g supernatant), NADPH, MgCl 2 and cysteamine. Tween-80 (1.5 mg/ml) is used to introduce enough substrate (300 μM) in the incubation mixture to saturate the ezyme (K(m) = 100 μM). Under these conditions the tritiated water released into the incubation medium reflects accurately the enzymic activity. The results obtained with this method are similar to the one obtained with a [4- 14 C]cholesterol technique (r = 0.96; P 3 H]cholesterol method is a complete independence from further metabolism of the first enzymic product, the 7α-hydroxycholesterol, the tritiated water representing the entire cholesterol 7α-hydroxylase activity. (orig.) [de

Equivalence groups of (2+1) dimensional diffusion equation

OpenAIRE

Özer, Saadet

2017-01-01

If a given set of differential equations contain somearbitrary functions, parameters, we have in fact a family of sets of equationsof the same structure. Almost all field equations of classical physichs havethis property, representing different materials with various paramaters.  Equivalence groups are defined as the groupof transformations which leave a given family of differential equationsinvariant. Therefore, equivalence group of family of differential equations isan important area within...

[Research on blood distribution of Tibetan population in Ali area].

Science.gov (United States)

Liu, X X; Li, D D; Li, H L; Hou, L A; Liu, Z J; Yang, H Y; Qiu, L

2017-12-12

Objective: To explore the distribution of ABO blood group in the healthy population in the Ali area of Tibet, and to analyze the difference of blood group distribution between the Tibetan population in Ali and the Tibet Tibetan population. Methods: The blood distribution of 509 apparent healthy volunteers of Tueti County and Gal County, Tibet, which were randomly selected from September to November in 2016; 137 Tibetan blood donors, from 2016 September to2017 July and 84 Tibetan blood donors from 2015 August to 2017 July was analyzed retrospectively. The blood type was tested by the slide method. By reviewing the Chinese and foreign language database, seven articles on Tibetan blood group distribution were obtained. And the data of the blood distribution of the Ali area population and the Tibet Tibetan population were compared. Results: The ABO phenotype frequencies of 507 apparent healthy people, 137 blood donors and 84 recipients were B>O>A>AB. The composition ratio were 36.1%, 34.5%, 21.5 %, 7.9%; 40.1%, 35.0%, 17.5%, 7.3%; 39.3%, 34.5%, 20.2%, 6.0%.There was no statistically significant difference in blood group distribution between the donors and the recipients ( P >0.05). And there was no significant difference in the blood group distribution between Ali and Shigatse, Nagqu, Lhasa, Shannan. However, the differences between Ali and Qamdo, Nyingchi areas were statistically significant. Conclusion: The geographical position of the blood from the west to east, B type shows a downward trend, O type blood composition ratio shows an upward trend.

7 CFR 1221.1 - Act.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1221.1 Section 1221.1 Agriculture Regulations of... INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.1 Act. Act means the Commodity Promotion, Research, and Information Act of 1996 (7 U.S.C. 7411-7425), and any amendments thereto. ...

Risk assessment calculations using MEPAS, an accepted screening methodology, and an uncertainty analysis for the reranking of Waste Area Groupings at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Shevenell, L.; Hoffman, F.O.; MacIntosh, D.

1992-03-01

The Waste Area Groupings (WAGs) at the Oak Ridge National Laboratory (ORNL) were reranked with respect to on- and off-site human health risks using two different methods. Risks associated with selected contaminants from each WAG for occupants of WAG 2 or an off-site area were calculated using a modified formulation of the Multimedia Environmental Pollutant Assessment System (MEPAS) and a method suitable for screening, referred to as the ORNL/ESD method (the method developed by the Environmental Sciences Division at ORNL) in this report. Each method resulted in a different ranking of the WAGs. The rankings from the two methods are compared in this report. All risk assessment calculations, except the original MEPAS calculations, indicated that WAGs 1; 2, 6, 7 (WAGs 2, 6 and 7 as one combined WAG); and 4 pose the greatest potential threat to human health. However, the overall rankings of the WAGs using constant parameter values in the different methods were inconclusive because uncertainty in parameter values can change the calculated risk associated with particular pathways, and hence, the final rankings. Uncertainty analysis using uncertainties about all model parameters were used to reduce biases associated with parameter selection and to more reliably rank waste sites according to potential risks associated with site contaminants. Uncertainty analysis indicates that the WAGs should be considered for further investigation, or remediation, in the following order: (1) WAG 1; (2) WAGs 2, 6, and 7 (combined); and 4; (3) WAGs 3, 5, and 9; and, (4) WAG 8

7 CFR 1218.1 - Act.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1218.1 Section 1218.1 Agriculture Regulations of... INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.1 Act. Act means the Commodity Promotion, Research, and Information Act of 1996 (7 U.S.C. 7401-7425; Pub. L. 104-127; 110 Stat...

7 CFR 1216.1 - Act.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1216.1 Section 1216.1 Agriculture Regulations of... ORDER Peanut Promotion, Research, and Information Order Definitions § 1216.1 Act. Act means the Commodity Promotion, Research, and Information Act of 1996 (7 U.S.C. 7401-7425; Public Law 104-127, 110 Stat...

7 CFR 1206.1 - Act.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1206.1 Section 1206.1 Agriculture Regulations of... Mango Promotion, Research, and Information Order Definitions § 1206.1 Act. Act means the Commodity Promotion, Research, and Information Act of 1996 (7 U.S.C. 7411-7425; Public Law 104-127; 110 Stat. 1029...

7 CFR 1212.1 - Act.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1212.1 Section 1212.1 Agriculture Regulations of..., Consumer Education, and Industry Information Order Definitions § 1212.1 Act. “Act” means the Commodity Promotion, Research, and Information Act of 1996, (7 U.S.C. 7411-7425), and any amendments to that Act. ...

7 CFR 1219.1 - Act.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Act. 1219.1 Section 1219.1 Agriculture Regulations of... INFORMATION Hass Avocado Promotion, Research, and Information Order Definitions § 1219.1 Act. Act means the Hass Avocado Promotion, Research, and Information Act of 2000, Public Law 106-387, 7 U.S.C. 7801-7813...

Production, biodistribution, and dosimetry of 47Sc-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid as a bone-seeking radiopharmaceutical

Directory of Open Access Journals (Sweden)

Fatemeh Fathi

2015-01-01

Full Text Available In this study 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid (DOTMP was used as the polyaminophosphonic acid carrier ligand and the therapeutic potential of the bone seeking radiopharmaceutical 47Sc-DOTMP was assessed by measuring its dosage–dependent skeletal uptake and then the absorbed radiation dose of human organs was estimated. Because of limited availability of 47Sc we performed some preliminary studies using 46Sc. 46Sc was produced with a specific activity of 116.58 MBq/mg (3.15 mCi/mg and radionuclide purity of 98%. 46Sc-DOTMP was prepared and an activity of 1.258 MBq (34 μCi at a chelant-to-metal ratio of 60:1 was administered to five groups of mice with each group containing 3 mice that were euthanized at 4, 24, 48, 96 and 192 h post administration. The heart, lungs, liver, spleen, kidneys, intestine, skin, muscle, and a femur were excised, weighed, and counted. The data were analyzed to determine skeletal uptake and source organ residence times and cumulated activities for 47Sc-DOTMP. 46Sc-DOTMP complex was prepared in radiochemical purity about 93%. In vitro stability of complex was evaluated at room temperature for 48 h. Biodistribution studies of complex in mice were studied for 7 days. The data were analyzed to estimate skeletal uptake and absorbed radiation dose of human organs using biodistribution data from mice. By considering the results, 47Sc-DOTMP is a possible therapeutic agent for using in palliation of bone pain due to metastatic skeletal lesions from several types of primary cancers in prostate, breast, etc.

IAEA INTOR workshop report, groups 2, 5, 7, 9, 10 and 15

International Nuclear Information System (INIS)

1980-02-01

In order to prove scientific feasibility of magnetic confinement fusion, large fusion devices are under construction in several countries (JT-60 in Japan, T-15 in U.S.S.R., TFTR in U.S.A. and JET in EC). International Tokamak Reactor (INTOR) Workshop was organized by the International Atomic Energy Agency (IAEA) to identify roles, objectives and characteristics of the next generation fusion device. This report is a compilation of the home task reports of six groups on INTOR engineering aspects by Japan Atomic Energy Research Institute for workshop sessions 2 and 3 held in 1979. Tasks of the respective groups are group 2: first wall/blanket/shield, group 5: magnetics, group 7: systems integration and structure, group 9: assembly and remote maintenance, group 10: radiation shielding and personnel access, group 15: safety and environment. (author)

39 CFR 223.1 - Headquarters and areas.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Headquarters and areas. 223.1 Section 223.1 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION RELATIONSHIPS AND COMMUNICATION CHANNELS § 223.1 Headquarters and areas. Headquarters provides policy guidance, procedures, and...

Molecular and Cytological Comparisons of Chromosomes 7el₁, 7el₂, 7E(e), and 7E ⁱ Derived from Thinopyrum.

Science.gov (United States)

Guo, Jun; He, Fang; Cai, Jin-Jin; Wang, Hong-Wei; Li, An-Fei; Wang, Hong-Gang; Kong, Ling-Rang

2015-01-01

Thinopyrum chromosomes 7el1, 7el2, 7E(e), and 7E(i), homoeologous to group 7 chromosomes of common wheat (Triticum aestivum), were determined to have many useful agronomical traits for wheat improvement. To analyze the genetic relationships among the 4 Thinopyrum 7E chromosomes, the conserved orthologous set markers, genomic in situ hybridization (GISH), and meiotic chromosome pairing were used in this study. The unweighted pair-group method with arithmetical averages (UPGMA) analysis indicated that 7el1, derived from T. ponticum, and 7E(i), derived from T. intermedium, were the most closely related. 7el2, derived from T. ponticum, was relatively distant from the 7el1-7E(i) complex. While 7E(e), derived from T. elongatum, was more distantly related to 7el1, 7el2, and 7E(i). This is the first report showing that 7el1 and 7E(i) may be similar, which could be explained by the similar chromosome signal distribution revealed by GISH as well as UPGMA analysis revealed by both molecular markers and the highest frequency of meiotic pairing. The newly developed genome-specific molecular markers may be useful for marker-assisted selection of Lr19, Bdv3, and Fhblop. © 2015 S. Karger AG, Basel.

Metaloproteinases 1 e 7 e câncer colorretal Metalloproteinases 1 and 7 and colorectal cancer

Directory of Open Access Journals (Sweden)

Mário Jucá

2008-09-01

Full Text Available A metaloproteinase-1 (MMP-1 e a metaloproteinase-7 (MMP-7 são proteinases da matriz extracelular (MEC, zinco-dependentes, envolvidas no processo inicial da carcinogênese por permitirem a invasão tumoral na célula e promover o processo de metastatização. O polimorfismo dessas proteinases tem sido estudado recentemente com o objetivo de validar susa expressão e/ou atividade como marcador prognóstico. Evidências cumulativas revelam importante papel das MMP's 1 e 7 em diferentes fases da carcinogênese. A MMP-1 tem ação direta sobre a principal proteína da MEC, que é o colágeno do tecido intersticial conectivo. Sua expressão aumentada neste tecido pode indicar alto potencial de disseminação tumoral em diferentes tipos de câncer, incluindo o colorretal. A associação deste aumento da expressão também parece ser verdadeira para a MMP-7.The metalloproteinase-1 (MMP-1 and metalloproteinase-7 (MMP-7 are proteinases of the extracellular matrix (MEC, zinc-dependent, involved in the initial process of carcinogenesis, allowing the invasion by the tumor cell and promoting the process of metastasis. The polymorphism of these proteinases has been studied recently in order to validate its expression and / or activity as a marker prognosis. Evidence shows cumulative important role of MMPs 1 and 7 in different stages of carcinogenesis. The MMP-1 is direct action on the main protein of the MEC, which is the collagen of interstitial connective tissue. Its increased expression in this tissue may indicate high potential for spread in different tumor types of cancer, including colorectal. The association of this increase of expression also appears to be true for MMP-7.

U-Pb zircon age for a volcanic suite in the Rankin Inlet Group, Rankin Inlet map area, District of Keewatin, Northwest Territories

International Nuclear Information System (INIS)

Tella, S.; Roddick, J.C.; VanBreemen, O.

1996-01-01

U-Pb zircon analyses from a felsic band within dominantly mafic volcanics of the Rankin Inlet Group yields a U-Pb upper concordia intercept age of 2663 ± 3 Ma. These supracrustals at Rankin Inlet appear to be 15-20 Ma younger than volcanics of the Kaminak Group in the Tavani area, 70 km to the southwest. The 2.68-2.66 Ga volcanism in the Tavani and Rankin Inlet areas coincided with the last stage of the main phase of magmatism in the Slave Structural Province. (author). 16 refs., 1 tab., 3 figs

U-Pb zircon age for a volcanic suite in the Rankin Inlet Group, Rankin Inlet map area, District of Keewatin, Northwest Territories

Energy Technology Data Exchange (ETDEWEB)

Tella, S; Roddick, J C; VanBreemen, O [Geological Survey of Canada, Ottawa, ON (Canada)

1997-12-31

U-Pb zircon analyses from a felsic band within dominantly mafic volcanics of the Rankin Inlet Group yields a U-Pb upper concordia intercept age of 2663 {+-} 3 Ma. These supracrustals at Rankin Inlet appear to be 15-20 Ma younger than volcanics of the Kaminak Group in the Tavani area, 70 km to the southwest. The 2.68-2.66 Ga volcanism in the Tavani and Rankin Inlet areas coincided with the last stage of the main phase of magmatism in the Slave Structural Province. (author). 16 refs., 1 tab., 3 figs.

7 CFR 760.1 - Administration.

Science.gov (United States)

2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 760.1 Section 760.1 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. This indemnity payment program will be carried out by FSA under the direction and supervision of...

Crystal structure of bis{μ2-2,2′-[(4,10-dimethyl-1,4,7,10-tetraazacyclododecane-1,7-diylbis(methylene]bis(4-oxo-4H-pyran-3-olato}dicobaltcalcium bis(perchlorate 1.36-hydrate

Directory of Open Access Journals (Sweden)

Patrizia Rossi

2017-12-01

Full Text Available The title compound, [CaCo2(C22H30N4O62](ClO42·1.36H2O or {Ca[Co(H–2L1]2}·2ClO4·1.36H2O {where L1 is 4,10-bis[(3-hydroxy-4-pyron-2-ylmethyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane}, is a trinuclear complex whose asymmetric unit comprises a quarter of the {Ca[Co(H–2L1]2}2+ trinuclear complex, half of a perchlorate ion and 0.34-water molecules. In the neutral [Co(H–2L1] moiety, the cobalt ion is hexacoordinated in a trigonal–prismatic fashion by the surrounding N4O2 donor set. A Ca2+ cation holds together two neutral [Co(H–2L1] moieties and is octacoordinated in a distorted trigonal–dodecahedral fashion by the surrounding O atoms belonging to the deprotonated oxide and carbonyl groups of two [Co(H–2L1] units. The coordination of the CoII cation preorganizes L1 and an electron-rich area forms, which is able to host hard metal ions. The comparison between the present structure and the previously published ones suggests a high versatility of this ligand; indeed, hard metal ions with different nature and dimensions lead to complexes having different stoichiometry (mono- and dinuclear monomers and trinuclear dimers or even a polymeric structure. The heterotrinuclear CoII–CaII–CoII complexes are connected in three dimensions via weak C—H...O hydrogen bonds, which are also responsible for the interactions with the perchlorate anions and the lattice water molecules. The perchlorate anion is disordered about a twofold rotation axis and was refined giving the two positions a fixed occupancy factor of 0.5. The crystal studied was refined as a two-component inversion twin [BASF parameter = 0.14 (4].

Revitalization Areas By Block Group

Data.gov (United States)

Department of Housing and Urban Development — Single Family Revitalization areas are HUD-designated neighborhoods in need of economic and community development and where there is already a strong commitment by...

26 CFR 1.1374-7 - Inventory.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Inventory. 1.1374-7 Section 1.1374-7 Internal... TAXES Small Business Corporations and Their Shareholders § 1.1374-7 Inventory. (a) Valuation. The fair market value of the inventory of an S corporation on the first day of the recognition period equals the...

7 CFR 1957.1 - General.

Science.gov (United States)

2010-01-01

... 7 Agriculture 14 2010-01-01 2009-01-01 true General. 1957.1 Section 1957.1 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE..., 7 CFR part 1900, Subpart B. Failure of private servicers to comply with FmHA or its successor agency...

Effects of Group 1 versus Group 2 carbapenems on the susceptibility of Acinetobacter baumannii to carbapenems: a before and after intervention study of carbapenem-use stewardship.

Science.gov (United States)

Yoon, Young Kyung; Yang, Kyung Sook; Lee, Seung Eun; Kim, Hyun Jeong; Sohn, Jang Wook; Kim, Min Ja

2014-01-01

Antimicrobial stewardship programs have been proposed for reducing bacterial resistance in the hospital environment. The purpose of this study was to investigate the impact of a carbapenem-use stewardship program on the susceptibility of Acinetobacter baumannii to Group 2 carbapenems. A before and after intervention study was conducted at a university hospital from September 2008 to February 2013. Three study periods were defined: Phase I, pre-intervention (months 1-18); Phase II, a postintervention period during which ertapenem use was mandated but carbapenem use was not restricted (months 19-36); and Phase III, a postintervention period during which Group 2 carbapenem use was restricted (months 37-54). During the study period, intervention resulted in diminished consumption of Group 2 carbapenems (antimicrobial use density (AUD): 21.3±6.0 in Phase I, 18.8±6.0 in Phase II, 16.1±4.4 in Phase III; P = 0.028) and increased consumption of ertapenem (AUD: 2.7±1.7 in Phase I, 7.2±4.5 in Phase II, 9.1±5.3 in Phase III; Pcarbapenem during the previous one month was positively and significantly associated with a subsequent increase in the proportion of carbapenem-resistant A. baumannii (CRAB) (P = 0.031). Implementing a carbapenem-use stewardship program featuring the preferential use of ertapenem for treating appropriate indications of infection resulted in reduced use of Group 2 carbapenems and had a positive impact on the susceptibility of A. baumannii to carbapenems. This approach could be integrated into CRAB-control strategies in hospitals.

Facial exercises for facial rejuvenation: a control group study.

Science.gov (United States)

De Vos, Marie-Camille; Van den Brande, Helen; Boone, Barbara; Van Borsel, John

2013-01-01

Facial exercises are a noninvasive alternative to medical approaches to facial rejuvenation. Logopedists could be involved in providing these exercises. Little research has been conducted, however, on the effectiveness of exercises for facial rejuvenation. This study assessed the effectiveness of 4 exercises purportedly reducing wrinkles and sagging of the facial skin. A control group study was conducted with 18 participants, 9 of whom (the experimental group) underwent daily training for 7 weeks. Pictures taken before and after 7 weeks of 5 facial areas (forehead, nasolabial folds, area above the upper lip, jawline and area under the chin) were evaluated by a panel of laypersons. In addition, the participants of the experimental group evaluated their own pictures. Evaluation included the pairwise presentation of pictures before and after 7 weeks and scoring of the same pictures by means of visual analogue scales in a random presentation. Only one significant difference was found between the control and experimental group. In the experimental group, the picture after therapy of the upper lip was more frequently chosen to be the younger-looking one by the panel. It cannot be concluded that facial exercises are effective. More systematic research is needed. © 2013 S. Karger AG, Basel.

Uncertainty analysis of an interfacial area reconstruction algorithm and its application to two group interfacial area transport equation validation

International Nuclear Information System (INIS)

Dave, A.J.; Manera, A.; Beyer, M.; Lucas, D.; Prasser, H.-M.

2016-01-01

Wire mesh sensors (WMS) are state of the art devices that allow high resolution (in space and time) measurement of 2D void fraction distribution over a wide range of two-phase flow regimes, from bubbly to annular. Data using WMS have been recorded at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) (Lucas et al., 2010; Beyer et al., 2008; Prasser et al., 2003) for a wide combination of superficial gas and liquid velocities, providing an excellent database for advances in two-phase flow modeling. In two-phase flow, the interfacial area plays an integral role in coupling the mass, momentum and energy transport equations of the liquid and gas phase. While current models used in best-estimate thermal-hydraulic codes (e.g. RELAP5, TRACE, TRACG, etc.) are still based on algebraic correlations for the estimation of the interfacial area in different flow regimes, interfacial area transport equations (IATE) have been proposed to predict the dynamic propagation in space and time of interfacial area (Ishii and Hibiki, 2010). IATE models are still under development and the HZDR WMS experimental data provide an excellent basis for the validation and further advance of these models. The current paper is focused on the uncertainty analysis of algorithms used to reconstruct interfacial area densities from the void-fraction voxel data measured using WMS and their application towards validation efforts of two-group IATE models. In previous research efforts, a surface triangularization algorithm has been developed in order to estimate the surface area of individual bubbles recorded with the WMS, and estimate the interfacial area in the given flow condition. In the present paper, synthetically generated bubbles are used to assess the algorithm’s accuracy. As the interfacial area of the synthetic bubbles are defined by user inputs, the error introduced by the algorithm can be quantitatively obtained. The accuracy of interfacial area measurements is characterized for different bubbles

Uncertainty analysis of an interfacial area reconstruction algorithm and its application to two group interfacial area transport equation validation

Energy Technology Data Exchange (ETDEWEB)

Dave, A.J., E-mail: akshayjd@umich.edu [Department of Nuclear Engineering and Rad. Sciences, University of Michigan, Ann Arbor, MI 48105 (United States); Manera, A. [Department of Nuclear Engineering and Rad. Sciences, University of Michigan, Ann Arbor, MI 48105 (United States); Beyer, M.; Lucas, D. [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Fluid Dynamics, 01314 Dresden (Germany); Prasser, H.-M. [Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich (Switzerland)

2016-12-15

Wire mesh sensors (WMS) are state of the art devices that allow high resolution (in space and time) measurement of 2D void fraction distribution over a wide range of two-phase flow regimes, from bubbly to annular. Data using WMS have been recorded at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) (Lucas et al., 2010; Beyer et al., 2008; Prasser et al., 2003) for a wide combination of superficial gas and liquid velocities, providing an excellent database for advances in two-phase flow modeling. In two-phase flow, the interfacial area plays an integral role in coupling the mass, momentum and energy transport equations of the liquid and gas phase. While current models used in best-estimate thermal-hydraulic codes (e.g. RELAP5, TRACE, TRACG, etc.) are still based on algebraic correlations for the estimation of the interfacial area in different flow regimes, interfacial area transport equations (IATE) have been proposed to predict the dynamic propagation in space and time of interfacial area (Ishii and Hibiki, 2010). IATE models are still under development and the HZDR WMS experimental data provide an excellent basis for the validation and further advance of these models. The current paper is focused on the uncertainty analysis of algorithms used to reconstruct interfacial area densities from the void-fraction voxel data measured using WMS and their application towards validation efforts of two-group IATE models. In previous research efforts, a surface triangularization algorithm has been developed in order to estimate the surface area of individual bubbles recorded with the WMS, and estimate the interfacial area in the given flow condition. In the present paper, synthetically generated bubbles are used to assess the algorithm’s accuracy. As the interfacial area of the synthetic bubbles are defined by user inputs, the error introduced by the algorithm can be quantitatively obtained. The accuracy of interfacial area measurements is characterized for different bubbles

Synthesis, in-vitro cytotoxicity of 1H-benzo[f]chromene derivatives and structure-activity relationships of the 1-aryl group and 9-position.

Science.gov (United States)

Mohamed, Hany M; Fouda, Ahmed M; Khattab, Essam S A E H; Agrody, Ahmed M El-; Afifi, Tarek H

2017-05-01

A series of 1H-benzo[f]chromene-2-carbonitriles was synthesized and evaluated for their cytotoxic activities against MCF-7, HCT-116, and HepG-2 cancer cells. The SAR studies reported that the substitution in the phenyl ring at 1-position of 1H-benzo[f]chromene nucleus with the specific group, H atom, or methoxy group at 9-position increases the ability of the molecule against the different cell lines.

Exploration and pharmacokinetic profiling of phenylalanine based carbamates as novel substance p 1-7 analogues.

Science.gov (United States)

Fransson, Rebecca; Nordvall, Gunnar; Bylund, Johan; Carlsson-Jonsson, Anna; Kratz, Jadel M; Svensson, Richard; Artursson, Per; Hallberg, Mathias; Sandström, Anja

2014-12-11

The bioactive metabolite of Substance P, the heptapeptide SP1-7 (H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH), has been shown to attenuate signs of hyperalgesia in diabetic mice, which indicate a possible use of compounds targeting the SP1-7 binding site as analgesics for neuropathic pain. Aiming at the development of drug-like SP1-7 peptidomimetics we have previously reported on the discovery of H-Phe-Phe-NH2 as a high affinity lead compound. Unfortunately, the pharmacophore of this compound was accompanied by a poor pharmacokinetic (PK) profile. Herein, further lead optimization of H-Phe-Phe-NH2 by substituting the N-terminal phenylalanine for a benzylcarbamate group giving a new type of SP1-7 analogues with good binding affinities is reported. Extensive in vitro as well as in vivo PK characterization is presented for this compound. Evaluation of different C-terminal functional groups, i.e., hydroxamic acid, acyl sulfonamide, acyl cyanamide, acyl hydrazine, and oxadiazole, suggested hydroxamic acid as a bioisosteric replacement for the original primary amide.

A Theoretical investigation of a potential high energy density compound 3,6,7,8-tetranitro-3,6,7,8-tetraaza-tricyclo[3.1.1.1(2,4]octane

Directory of Open Access Journals (Sweden)

Guozheng Zhao

2013-01-01

Full Text Available The B3LYP/6-31G (d density functional theory (DFT method was used to study molecular geometry, electronic structure, infrared spectrum (IR and thermodynamic properties. Heat of formation (HOF and calculated density were estimated to evaluate detonation properties using Kamlet-Jacobs equations. Thermal stability of 3,6,7,8-tetranitro-3,6,7,8-tetraaza-tricyclo [3.1.1.1(2,4]octane (TTTO was investigated by calculating bond dissociation energy (BDE at the unrestricted B3LYP/6-31G(d level. Results showed the N-NO2 bond is a trigger bond during the thermolysis initiation process. The crystal structure obtained by molecular mechanics (MM methods belongs to P2(1/C space group, with cell parameters a = 8.239 Å, b = 8.079 Å, c = 16.860 Å, Z = 4 and r = 1.922 g cm-3. Both detonation velocity of 9.79 km s-1 and detonation pressure of 44.22 GPa performed similarly to CL-20. According to the quantitative standards of energetics and stability, TTTO essentially satisfies this requirement as a high energy density compound (HEDC.

Application of gis on determination of flood prone areas and critical arterial road network by using chaid method in bandung area

Directory of Open Access Journals (Sweden)

Darwin

2018-01-01

Full Text Available Floods in Bandung area often occur when the rainfall is high then the water volume exceed the capacity of Citarum watershed. Floods cause economic and social losses. The purpose of this research is to get the GIS application model in the estimation of puddle area and road network in Bandung Metropolitan Area has disturbed.Geospatial map preparation methodology used statistical data from 11041 flood points, which divided into two groups, 7729 flood points to estimate the decision tree model and 3312 flood points to validate the model. The process of making flood vulnerability maps is approached by Chi-square Automatic Interaction Detection (CHAID method, and validation using Receiver Operating Characteristic (ROC method. Validation results in the area under the curve with a value of 93.1% for success rate and 92.7% for the prediction level.Chaid result is class 0 - 0,047 covering 76,68% area; Grades of 0.047-0.307 include 5.37%; Grades 0.307 - 0.599 (Low covering 5.36%; Grades 0.599 to 0.4444 include 5.31% and grade 0.844-1 (high covering 7.27% of the research area. Flood-prone road network is Link from Rancaekek (Area of PT Kahatex, link from Solokan Jeruk (Cicalengka-Majalaya, Link Baleendah, and linkDayeuhkolot (M.Toha - Andir

Mandatory Class 1 Federal Areas Web Service

Data.gov (United States)

U.S. Environmental Protection Agency — This web service contains the following layers: Mandatory Class 1 Federal Area polygons and Mandatory Class 1 Federal Area labels in the United States. The polygon...

Efficacy of the nucleotide-binding oligomerzation domain 1 inhibitor Nodinhibit-1 on corneal alkali burns in rats

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Xu Huang

2015-10-01

Full Text Available AIM:To evaluate the therapeutic effect of Nodinhibit-1 on alkali-burn-induced corneal neovascularization (CNV and inflammation.The nucleotide-binding oligomerzation domain 1 (NOD1 is a potent angiogenic gene.METHODS:The alkali-burned rat corneas (32 right eyes were treated with eye drops containing Nodinhibit-1 or phosphate buffered solution (PBS, PH 7.4 only, four times per day. CNV and inflammation were monitored using slit lamp microscopy, and the area of CNV was measured by formula. Vascular endothelial growth factor (VEGF and pigment epithelium-derived factor (PEDF was determined by Western blot analysis. The TUNEL assay was used to assess the corneal apoptosis cells.RESULTS:Alkali-burn-induced progressive CNV and inflammation in the cornea. After treatment for 7d and 14d, there were statistically significant differences in the CNV areas and inflammatory index on that between two group(P＜0.05, respectively. Epithelial defect quantification showed a significant difference between the two groups at days 4 and 7 after the alkali burns (P＜0.05. The apoptotic cells on days 1, 4, and 7 between the two groups showed significant differences at all time points (P<0.05, respectively. Compared to that in control group, the protein level of VEGF expression was significantly reduced whereas the PEDF expression was increase in the Nodinhibit-1 groups on day 14 (P＜0.05, respectively＝.CONCLUSION:Topical application of 10.0 μg/mL Nodinhibit-1 may have potential effect for the alkali burn-induced CNV and inflammation. The effect of Nodinhibit-1 on CNV may be by regulation the equilibrium of VEGF and PEDF in the wounded cornea.

Effects of Group 1 versus Group 2 carbapenems on the susceptibility of Acinetobacter baumannii to carbapenems: a before and after intervention study of carbapenem-use stewardship.

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Young Kyung Yoon

Full Text Available OBJECTIVE: Antimicrobial stewardship programs have been proposed for reducing bacterial resistance in the hospital environment. The purpose of this study was to investigate the impact of a carbapenem-use stewardship program on the susceptibility of Acinetobacter baumannii to Group 2 carbapenems. METHODS: A before and after intervention study was conducted at a university hospital from September 2008 to February 2013. Three study periods were defined: Phase I, pre-intervention (months 1-18; Phase II, a postintervention period during which ertapenem use was mandated but carbapenem use was not restricted (months 19-36; and Phase III, a postintervention period during which Group 2 carbapenem use was restricted (months 37-54. RESULTS: During the study period, intervention resulted in diminished consumption of Group 2 carbapenems (antimicrobial use density (AUD: 21.3±6.0 in Phase I, 18.8±6.0 in Phase II, 16.1±4.4 in Phase III; P = 0.028 and increased consumption of ertapenem (AUD: 2.7±1.7 in Phase I, 7.2±4.5 in Phase II, 9.1±5.3 in Phase III; P<0.001. The use of autoregressive-error models showed that in contrast with ertapenem use, the use of Group 2 carbapenem during the previous one month was positively and significantly associated with a subsequent increase in the proportion of carbapenem-resistant A. baumannii (CRAB (P = 0.031. CONCLUSIONS: Implementing a carbapenem-use stewardship program featuring the preferential use of ertapenem for treating appropriate indications of infection resulted in reduced use of Group 2 carbapenems and had a positive impact on the susceptibility of A. baumannii to carbapenems. This approach could be integrated into CRAB-control strategies in hospitals.

Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats

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Aghdas Dehghani

2015-01-01

Full Text Available Background. The accompanied role of Mas receptor (MasR, bradykinin (BK, and female sex hormone on renal blood flow (RBF response to angiotensin 1-7 is not well defined. We investigated the role of MasR antagonist (A779 and BK on RBF response to Ang 1-7 infusion in ovariectomized estradiol-treated rats. Methods. Ovariectomized Wistar rats received estradiol (OVE or vehicle (OV for two weeks. Catheterized animals were subjected to BK and A799 infusion and mean arterial pressure (MAP, RBF, and renal vascular resistance (RVR responses to Ang 1-7 (0, 100, and 300 ng kg−1 min−1 were determined. Results. Percentage change of RBF (%RBF in response to Ang1-7 infusion increased in a dose-dependent manner. In the presence of BK, when MasR was not blocked, %RBF response to Ang 1-7 in OVE group was greater than OV group significantly (P<0.05. Infusion of 300 ng kg−1 min−1 Ang 1-7 increased RBF by 6.9±1.9% in OVE group versus 0.9±1.8% in OV group. However when MasR was blocked, %RBF response to Ang 1-7 in OV group was greater than OVE group insignificantly. Conclusion. Coadministration of BK and A779 compared to BK alone increased RBF response to Ang 1-7 in vehicle treated rats. Such observation was not seen in estradiol treated rats.

Nonclassical dynamics of the methyl group in 1,1,1-triphenylethane. Evidence from powder 1H NMR spectra

KAUST Repository

Osior, Agnieszka

2017-03-14

According to the damped quantum rotation (DQR) theory, hindered rotation of methyl groups, evidenced in nuclear magnetic resonance (NMR) line shapes, is a nonclassical process. It comprises a number of quantum-rate processes measured by two different quantum-rate constants. The classical jump model employing only one rate constant is reproduced if these quantum constants happen to be equal. The values of their ratio, or the nonclassicallity coefficient, determined hitherto from NMR spectra of single crystals and solutions range from about 1.20 to 1.30 in the latter case to above 5.0 in the former, with the value of 1 corresponding to the jump model. Presently, first systematic investigations of the DQR effects in wide-line NMR spectra of a powder sample are reported. For 1,1,1-triphenylethane deuterated in the aromatic positions, the relevant line-shape effects were monitored in the range 99–121 K. The values of the nonclassicality coefficient dropping from 2.7 to 1.7 were evaluated in line shape fits to the experimental powder spectra from the range 99–108 K. At these temperatures, the fits with the conventional line-shape model are visibly inferior to the DQR fits. Using a theoretical model reported earlier, a semiquantitative interpretation of the DQR parameters evaluated from the spectra is given. It is shown that the DQR effects as such can be detected in wide-line NMR spectra of powdered samples, which are relatively facile to measure. However, a fully quantitative picture of these effects can only be obtained from the much more demanding experiments on single crystals.

Morphometric analysis of feedforward pathways from the primary somatosensory area (S1 of rats

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A.L. de Sá

2016-01-01

Full Text Available We used biotinylated dextran amine (BDA to anterogradely label individual axons projecting from primary somatosensory cortex (S1 to four different cortical areas in rats. A major goal was to determine whether axon terminals in these target areas shared morphometric similarities based on the shape of individual terminal arbors and the density of two bouton types: en passant (Bp and terminaux (Bt. Evidence from tridimensional reconstructions of isolated axon terminal fragments (n=111 did support a degree of morphological heterogeneity establishing two broad groups of axon terminals. Morphological parameters associated with the complexity of terminal arbors and the proportion of beaded Bp vs stalked Bt were found to differ significantly in these two groups following a discriminant function statistical analysis across axon fragments. Interestingly, both groups occurred in all four target areas, possibly consistent with a commonality of presynaptic processing of tactile information. These findings lay the ground for additional work aiming to investigate synaptic function at the single bouton level and see how this might be associated with emerging properties in postsynaptic targets.

Seismic characteristics of the area around the Philippine Research Reactor (PRR-1)

International Nuclear Information System (INIS)

Paz, L.R. de la; Palattao, M.V.B.; Estacio, J.F.; Ragiles, S.O.

1989-01-01

The seismic characteristics of the PRR-1 site are discussed. A study was made about seismicity, acceleration values and the recent seismic history of the site. The incidence of seismic events in Manila and Quezon City and their intensities were also recorded and plotted. The liquefaction potential was calculated. No zone of liquefaction was found existing in the site area. (Auth.). 6 tabs., 18 refs., 7 figs

Functional requirements of the borrow area and haul route for the Waste Area Grouping projects at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Miller, D.G.

1992-09-01

This report describes the mission and functional requirements for the development of a borrow area and the associated haul route to support closure and/or remediation of Waste Area Grouping (WAG) 6 and other WAGs at Oak Ridge National Laboratory. This document specifies the basic functional requirements that must be met by the borrow area and haul route developed to produce low-permeability soil for the covers or caps at WAG 6

7 CFR 948.4 - Area.

Science.gov (United States)

2010-01-01

..., Huerfano, Las Animas, Mineral, Archuleta, in the State of Colorado, and all counties in said State, south... Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE IRISH POTATOES GROWN IN COLORADO Order Regulating Handling Definitions § 948.4 Area. Area means any of the subdivisions of the State of Colorado as...

Permian Triassic palynofloral transition in Chintalapudi area ...

Indian Academy of Sciences (India)

The entire 606 m-thick sedimentary sequence in borecore MCP-7 from Chintalapudi area, Chintalapudi sub-basin has been lithologically designated as Kamthi Formation. However, the palynological investigation revealed five distinct palynoassemblages, which essentially fall under two groups, one group ...

meso-4,4′-Difluoro-2,2′-{[(3aR,7aS-2,3,3a,4,5,6,7,7a-octahydro-1H-1,3-benzimidazole-1,3-diyl]bis(methylene}diphenol

Directory of Open Access Journals (Sweden)

Augusto Rivera

2013-02-01

Full Text Available In the crystal structure of the title compound, C21H24F2N2O2, there are two intramolecular O—H...N hydrogen bonds involving the N atoms of the imidazolidine ring and the hydroxy groups. The crystal studied was a meso compound obtained by the reaction of the aminal (2S,7R,11S,16R-1,8,10,17-tetraazapentacyclo[8.8.1.18,17.02,7.011,16]cosane with 4-fluorophenol. The imidazolidine ring has a twisted conformation with a CH—CH—N—CH2 torsion angle of 44.99 (14° and, surprisingly, the lone pairs of the N atoms are disposed in a syn isomerism, making the title compound an exception to the typical `rabbit-ear effect' in 1,2-diamines. In the crystal, molecules are linked via C—H...F hydrogen bonds, forming chains along the c-axis direction. These chains are linked via another C—H...F hydrogen bond, forming a three-dimensional network.

Immune protection of microneme 7 (EmMIC7) against Eimeria maxima challenge in chickens.

Science.gov (United States)

Huang, Jingwei; Zhang, Zhenchao; Li, Menghui; Song, Xiaokai; Yan, Ruofeng; Xu, Lixin; Li, Xiangrui

2015-10-01

In the present study, the immune protective effects of recombinant microneme protein 7 of Eimeria maxima (rEmMIC7) and a DNA vaccine encoding this antigen (pVAX1-EmMIC7) on experimental challenge were evaluated. Two-week-old chickens were randomly divided into five groups. Experimental groups of chickens were immunized with 100 μg DNA vaccine pVAX1-MIC7 or 200 μg rEmMIC7, while control groups of chickens were injected with pVAX1 plasmid or sterile phosphate buffered saline (PBS). The results showed that the anti-EmMIC7 antibody titres in chickens of both rEmMIC7 and pVAX1-MIC7 groups were significantly higher as compared to PBS and pVAX1 control (P maxima challenge in chickens and it could be an effective antigen candidate for the development of new vaccines against E. maxima.

Adverse cardiac effects of exogenous angiotensin 1-7 in rats with subtotal nephrectomy are prevented by ACE inhibition.

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Louise M Burrell

Full Text Available We previously reported that exogenous angiotensin (Ang 1-7 has adverse cardiac effects in experimental kidney failure due to its action to increase cardiac angiotensin converting enzyme (ACE activity. This study investigated if the addition of an ACE inhibitor (ACEi to Ang 1-7 infusion would unmask any beneficial effects of Ang 1-7 on the heart in experimental kidney failure. Male Sprague-Dawley rats underwent subtotal nephrectomy (STNx and were treated with vehicle, the ACEi ramipril (oral 1mg/kg/day, Ang 1-7 (subcutaneous 24 μg/kg/h or dual therapy (all groups, n = 12. A control group (n = 10 of sham-operated rats were also studied. STNx led to hypertension, renal impairment, cardiac hypertrophy and fibrosis, and increased both left ventricular ACE2 activity and ACE binding. STNx was not associated with changes in plasma levels of ACE, ACE2 or angiotensin peptides. Ramipril reduced blood pressure, improved cardiac hypertrophy and fibrosis and inhibited cardiac ACE. Ang 1-7 infusion increased blood pressure, cardiac interstitial fibrosis and cardiac ACE binding compared to untreated STNx rats. Although in STNx rats, the addition of ACEi to Ang 1-7 prevented any deleterious cardiac effects of Ang 1-7, a limitation of the study is that the large increase in plasma Ang 1-7 with ramipril may have masked any effect of infused Ang 1-7.

Paleomagnetic study of areas B1, C1 and E2

International Nuclear Information System (INIS)

Barton, C.; Sopher, C.

1982-01-01

Sediments from all three areas retain a stable primary remanence with a small viscous overprint which can be removed by AF cleaning. This marginally reduces the scatter in NRM data and improves the constraints on some reversal boundaries. Excellent reversal stratigraphies exist in all cores, particularly within area E2, with the exception of core B1-43P. This core is normally magnetized throughout and has a larger viscous component than other cores. Sedimentation rates are slower during the Brunhes epoch in all cores except C1-32P and C1-33P. Cores C1-34P and E2-46P have almost constant sedimentation rates throughout. The abnormally low average sedimentation rate during the Brunhes in core C1-35P suggest a loss of up to 2m of sediment, either during coring or by in situ erosion. Overall sedimentation rates are highest in area B1, lowest in area E2, and show least variation between cores in area E2. There is no general correlation between lithology and the paleomagnetic record. Ash layers and horizons with abnormally low water contents sometimes coincide with spikes in the paleomagnetic records

Araxa Group in the type-area: A fragment of Neoproterozoic oceanic crust in the Brasilia Fold Belt

International Nuclear Information System (INIS)

Seer, Hildor Jose; Brod, Jose Affonso; Fuck, Reinhardt Adolfo; Pimentel, Marcio Martins; Boaventura, Geraldo Resende; Dardenne, Marcel Auguste

2001-01-01

This study reviews the geological characteristics and puts forward a new evolution model for the Araxa Group in its type-area, the southern segment of the Neo proterozoic Brasilia Belt, Minas Gerais, Brazil. The Araxa Group is confined within a thrust sheet belonging to a syn formal regional fold, the Araxa Syn form, overlying two other thrust sheets made of the Ibia and Canastra Groups. The Araxa Group is described as a tectono stratigraphic terrane in the sense of Howell (1993). It comprises an igneous mafic sequence, with fine and coarse grained amphibolites, associated with pelitic meta sedimentary rocks, and subordinate psanmites. All rocks were metamorphosed to amphibolite facies at ca. 630 Ma ago and were intruded by collisional granites. The amphibolites represent original basaltic and gabbroic rocks, with minor ultramafic (serpentinite/ amphibole-talc schist). The basalts are similar to high Fe O tholeiites, with REE signatures that resemble E-MORB and ε Nd(T) =+ 1.1. The meta sedimentary rocks are interpreted as the result of a marine deep-water sedimentation. They have Sm-Nd model ages of 1,9 Ga, and ε Nd(T) = -10.21. The amphibolites and metasediments could represent a fragment of back-arc oceanic crust. The data presented here differ significantly from the original definition of Barbosa et al. (1970) who describe the Araxa Group as a pelitic/psanmitic sequence and the collisional granites as a basement complex. (author)

Cross calibration of the Landsat-7 ETM+ and EO-1 ALI sensor

Science.gov (United States)

Chander, G.; Meyer, D.J.; Helder, D.L.

2004-01-01

As part of the Earth Observer 1 (EO-1) Mission, the Advanced Land Imager (ALI) demonstrates a potential technological direction for Landsat Data Continuity Missions. To evaluate ALI's capabilities in this role, a cross-calibration methodology has been developed using image pairs from the Landsat-7 (L7) Enhanced Thematic Mapper Plus (ETM+) and EO-1 (ALI) to verify the radiometric calibration of ALI with respect to the well-calibrated L7 ETM+ sensor. Results have been obtained using two different approaches. The first approach involves calibration of nearly simultaneous surface observations based on image statistics from areas observed simultaneously by the two sensors. The second approach uses vicarious calibration techniques to compare the predicted top-of-atmosphere radiance derived from ground reference data collected during the overpass to the measured radiance obtained from the sensor. The results indicate that the relative sensor chip assemblies gains agree with the ETM+ visible and near-infrared bands to within 2% and the shortwave infrared bands to within 4%.

Operation REDWING Commander Task Group 7.3, Operation Plan Number 1-56.

Science.gov (United States)

1956-01-24

Radio Circuit Description SI. Tab B - Radio Frequency Plan 7:: Tab C - Aircraft Radio Frequency List Tab D - Radio Circuit Diagram Appendix 2 - Radio...Frequency Plan C Aircraft Radio Frequency List D Radio Circuit Diagrams 2 - Radio Call Signs and Code ’Words N. ROHI5BE2 E LCDR, U. S. Navy Flag...appendix. TABS: A Radio Circuit Description B Radio Frequency Plan C Aircraft Radio Frequency List D Radio Circuit Diagrams Joint Task Force SEVEN Task

26 CFR 1.547-7 - Effective date.

Science.gov (United States)

2010-04-01

... TAXES (CONTINUED) Personal Holding Companies § 1.547-7 Effective date. The deduction for deficiency dividends, in computing personal holding company tax for any taxable year, is allowable only with respect to... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Effective date. 1.547-7 Section 1.547-7 Internal...

36 CFR 223.7 - Permission for free use of timber outside free-use areas.

Science.gov (United States)

2010-07-01

..., DEPARTMENT OF AGRICULTURE SALE AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER General Provisions § 223.7 Permission for free use of timber outside free-use areas. Similar material may be cut outside of a free-use area without permit in cases of emergency, but the person taking such material shall promptly notify...

Chernobyl Studies Project: Working group 7.0, Environmental transport and health effects. Progress report, March--September 1994

Energy Technology Data Exchange (ETDEWEB)

Anspaugh, L.R.; Hendrickson, S.M. [eds.

1994-12-01

In April 1988, the US and the former-USSR signed a Memorandum of Cooperation (MOC) for Civilian Nuclear Reactor Safety; this MOC was a direct result of the accident at the Chernobyl Nuclear Power Plant Unit 4 and the following efforts by the two countries to implement a joint program to improve the safety of nuclear power plants and to understand the implications of environmental releases. A Joint Coordinating Committee for Civilian Nuclear Reactor Safety (JCCCNRS) was formed to implement the MOC. The JCCCNRS established many working groups; most of these were the responsibility of the Nuclear Regulatory Commission, as far as the US participation was concerned. The lone exception was Working Group 7 on Environmental Transport and Health Effects, for which the US participation was the responsibility of the US Department of Energy (DOE). The purpose of Working Group 7 was succintly stated to be, ``To develop jointly methods to project rapidly the health effects of any future nuclear reactor accident.`` To implement the work DOE then formed two subworking groups: 7.1 to address Environmental Transport and 7.2 to address Health Effects. Thus, the DOE-funded Chernobyl Studies Project began. The majority of the initial tasks for this project are completed or near completion. The focus is now turned to the issue of health effects from the Chernobyl accident. Currently, we are involved in and making progress on the case-control and co-hort studies of thyroid diseases among Belarussian children. Dosimetric aspects are a fundamental part of these studies. We are currently working to implement similar studies in Ukraine. A major part of the effort of these projects is supporting these studies, both by providing methods and applications of dose reconstruction and by providing support and equipment for the medical teams.

Crystal structure of 1-isopropyl-4,7-dimethyl-3-nitronaphthalene

Directory of Open Access Journals (Sweden)

Ahmed Benharref

2015-09-01

Full Text Available The title compound, C15H17NO2, was synthesized from a mixture of α-himachalene (2-methylene-6,6,9-trimethylbicyclo[5.4.01,7]undec-8-ene and β-himachalene (2,6,6,9-tetramethylbicyclo[5.4.01,7]undeca-1,8-diene, which were isolated from an oil of the Atlas cedar (Cedrus Atlantica. The naphthalene ring system makes dihedral angles of 68.6 (2 and 44.3 (2°, respectively, with its attached isopropyl C/C/C plane and the nitro group. In the crystal, molecules held together by a C—H...O interaction, forming a chain along [-101].

Model calculations on LIS. II1. 2-, 3- and 7-substituted indanones

International Nuclear Information System (INIS)

Hofer, O.

1979-01-01

The space close to the coordination site of 1-indanone is modified systematically by placing alkyl groups of different bulkiness on C-2, C-3 and C-7, resp. The 1 H-LIS for the compounds are interpreted using the one site and two site model for carbonyl. Precautionary measures are discussed for both models to give reliable results in the calculation. (author)

26 CFR 1.801-7 - Variable annuities.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Variable annuities. 1.801-7 Section 1.801-7...) INCOME TAXES Life Insurance Companies § 1.801-7 Variable annuities. (a) In general. (1) Section 801(g)(1) provides that for purposes of part I, subchapter L, chapter 1 of the Code, an annuity contract includes a...

Summary of Synoptic Meteorological Observations. North American Coastal Marine Areas - Revised. Atlantic and Gulf Coasts. Volume I. Revised. Area 1 - Belle Isle Strait. Area 2 - Osv Bravo. Area 3 - NE Newfoundland Coast. Area 4 - SE Newfoundland Coast. Area 5 - Placentia Bay South. Area 6 - Cabot Strait. Area 7 - Anticosti Island

Science.gov (United States)

1975-05-01

H71 JUNE T4BU 1? IKEA 0006 CABPT STKAIT »6.7N 58.in PCT FKfO Of AID TEMPERATURE (DE6 Fl ANn THE OCCURRENCE OF FOB IWITHGUT PRECIPITATION...OVE»-iLL) m7*-1970 JULY T«»LE IT IKEA 0006 CilOT STIUIT 46.6N Sa.lW PCT f»P0 0» Mi TEMPE»»TU»E (D6G Fl »MB THE

Proceedings of the Annual Meeting of the North American Chapter of the International Group for the Psychology of Mathematics Education (16th, Baton Rouge, Louisiana, November 5-8, 1994). Volume 1: Plenary Sessions, Technology Focus Groups, Discussion Groups and Research Papers, Oral Reports and Posters.

Science.gov (United States)

Kirshner, David, Ed.

This volume contains the full text of 2 plenary papers and 26 research reports. In addition, brief, usually one-page, reports are provided for 6 discussion groups, 10 technology focus groups, 7 symposiums, 7 oral presentations, and 17 position sessions. The two full plenary reports are: (1) "Problems of Reification: Representations and…

Double cascade erbium fiber laser at 1.7 µm, 2.7 µm, and 1.6 µm

NARCIS (Netherlands)

Schneider, J.; Frerichs, Ch.; Carbonnier, C.; Unrau, U.B.; Pollnau, Markus; Lüthy, W.; Weber, H.P.

The output power of the erbium laser at 2.7 um (4I11/2 -> 4I13/2) is enhanced due to simultaneous laser action at 1.7 um (4S3/2 -> 4I9/2) and 1.6 um (4I13/2 -> 4I15/2) in an Er3+-doped fluorozirconate fiber. The laser cascade overwhelms the saturation effect for the transition at 2.7 um by

Group-level variations in motor representation areas of thenar and anterior tibial muscles: Navigated Transcranial Magnetic Stimulation Study.

Science.gov (United States)

Niskanen, Eini; Julkunen, Petro; Säisänen, Laura; Vanninen, Ritva; Karjalainen, Pasi; Könönen, Mervi

2010-08-01

Navigated transcranial magnetic stimulation (TMS) can be used to stimulate functional cortical areas at precise anatomical location to induce measurable responses. The stimulation has commonly been focused on anatomically predefined motor areas: TMS of that area elicits a measurable muscle response, the motor evoked potential. In clinical pathologies, however, the well-known homunculus somatotopy theory may not be straightforward, and the representation area of the muscle is not fixed. Traditionally, the anatomical locations of TMS stimulations have not been reported at the group level in standard space. This study describes a methodology for group-level analysis by investigating the normal representation areas of thenar and anterior tibial muscle in the primary motor cortex. The optimal representation area for these muscles was mapped in 59 healthy right-handed subjects using navigated TMS. The coordinates of the optimal stimulation sites were then normalized into standard space to determine the representation areas of these muscles at the group-level in healthy subjects. Furthermore, 95% confidence interval ellipsoids were fitted into the optimal stimulation site clusters to define the variation between subjects in optimal stimulation sites. The variation was found to be highest in the anteroposterior direction along the superior margin of the precentral gyrus. These results provide important normative information for clinical studies assessing changes in the functional cortical areas because of plasticity of the brain. Furthermore, it is proposed that the presented methodology to study TMS locations at the group level on standard space will be a suitable tool for research purposes in population studies. 2010 Wiley-Liss, Inc.

26 CFR 1.382-8 - Controlled groups.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Controlled groups. 1.382-8 Section 1.382-8 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.382-8 Controlled groups. (a) Introduction. This section...

Occurrence and characterization of Shiga toxin-producing Escherichia coli O157:H7 and other non-sorbitol-fermenting E. coli in cattle and humans in urban areas of Morogoro, Tanzania.

Science.gov (United States)

Lupindu, Athumani M; Olsen, John E; Ngowi, Helena A; Msoffe, Peter L M; Mtambo, Madundo M; Scheutz, Flemming; Dalsgaard, Anders

2014-07-01

Escherichia coli strains such as Shiga toxin-producing E. coli (STEC), enteropathogenic E. coli, enterotoxigenic, attaching, and effacing E. coli, and enteroinvasive E. coli cause diarrhea in humans. Although other serotypes exist, the most commonly reported STEC in outbreaks is O157:H7. A cross-sectional study was conducted to isolate and characterize non-sorbitol-fermenting (NSF) E. coli O157:H7 from urban and periurban livestock settings of Morogoro, Tanzania. Human stool, cattle feces, and soil and water samples were collected. Observations and questionnaire interview studies were used to gather information about cattle and manure management practices in the study area. E. coli were isolated on sorbitol MacConkey agar and characterized by conventional biochemical tests. Out of 1049 samples, 143 (13.7%) yielded NSF E. coli. Serological and antimicrobial tests and molecular typing were performed to NSF E. coli isolates. These procedures detected 10 (7%) pathogenic E. coli including STEC (n=7), enteropathogenic E. coli (EPEC) (n=2), and attaching and effacing E. coli (A/EEC) (n=1) strains. The STEC strains had the ability to produce VT1 and different VT2 toxin subtypes that caused cytopathic effects on Vero cells. The prevalence of STEC in cattle was 1.6%, out of which 0.9% was serotype O157:H7 and the overall prevalence of diarrheagenic E. coli in cattle was 2.2%. The serotypes O157:H7, O142:H34, O113:H21, O+:H-, O+:H16, and O25:H4 were identified. One ESBL-producing isolate showed the MLST type ST131. To our knowledge, this is the first finding in Tanzania of this recently emerged worldwide pandemic clonal group, causing widespread antimicrobial-resistant infections, and adds knowledge of the geographical distribution of ST131. Cattle manure was indiscriminately deposited within residential areas, and there was direct contact between humans and cattle feces during manure handling. Cattle and manure management practices expose humans, animals, and the environment

Self-assembled monolayers with different chemical group substrates for the study of MCF-7 breast cancer cell line behavior

International Nuclear Information System (INIS)

Yan, Hongji; Yin, Yanbin; Li, Yu; Tian, Weiming; Zhang, Song; Nie, Yongzhan; He, Jin; Wang, Xiumei; Cui, Fuzhai; Chen, Xiongbiao

2013-01-01

The interactions between cancer cells and the extracellular matrix (ECM) are important with respect to a number of cell behavoirs, yet remain unclear. In this study, self-assembled monolayers with different terminal chemical groups (hydroxyl (-OH), carboxyl (-COOH), animo (-NH 2 ), mercapto (-SH), and methyl (-CH 3 )) were employed as substrates for the culture of MCF-7 cells to examine effects on cell behavior. Cell spreading was investigated by scanning electron microscopy, tallin expression by immunofluorescence, proliferation rate by counting cell numbers, cell cycle by flow cytometry, metabolism by high-performance liquid chromatography and cell migration by live cell imaging. Annexin V-FITC (fluorescein isothiocyanate) and JC-1 assays were performed to determine cell apoptosis and mitochondrial membrane potential, respectively. Our results demonstrate the varied behaviors of MCF-7 cells in response to different chemical groups. Specifically, NH 2 and COOH terminal functional groups promote proliferation, the production of lactic acid and mobility of MCF-7 cells; SH and OH terminal groups enhance the expression and distribution of tallin but result in weak cell proliferation, metabolism, spreading and mobility. These results are meaningful for uncovering the interactions between the ECM and cancer cells; they are potentially useful for designing novel cancer treatment strategies. (paper)

[CYP7A1 gene polymorphism and the characteristics of dyslipidemias in patients with nonalcoholic fatty liver disease concurrent with hypothyroidism].

Science.gov (United States)

Zhaldak, D A; Melekhovets, O K; Orlovskyi, V F

To investigate the association of the polymorphic variants -204A > C (rs 3808607) in the CYP7A1 gene with the development of dyslipidemias in healthy individuals, in patients with non-alcoholic fatty liver disease (NAFLD) and in those with NAFLD concurrent with hypothyroidism. DNA samples and lipidograms were examined in 180 patients, including 60 healthy individuals (Group 1), 60 patients with hypothyroidism concurrent with NAFLD (Group 2), and 60 patients with NAFLD (Group 3). All the patients underwent ultrasound examination of the thyroid gland and abdominal cavity organs; FibroMax scores were calculated. All the study groups most frequently showed a homozygous AA genotype (86.6% of cases in Group 1, 80% in Group 2, and 83.3% in Group 3). The development of NAFLD in CC genotype carriers is characterized by the most pronounced changes in lipid metabolism (atherogenic index (AI), 7.32 in Group 3) compared to the genotypes AA (AI, 4.56 in Group 2 and 1.73 in Group 1) and CC (AI, 6.43 in Group 2 and 2.52 in Group 1) in functional insufficiency of thyroid hormones and relative normal conditions. The analysis of the relationship of polymorphic variants CYP7A1 rs 38088607 to lipid metabolic disturbances in the study groups showed that the significantly higher levels of atherogenic cholesterol fractions were determined in the CC genotype compared to AA genotype carriers and they did not depend on the presence of NAFLD and hypothyroidism. The findings make it possible to consider the AA homozygous genotype of variant mutation CYP7A1 rs 38088607 as protective against dyslipidemia. However, in functional insufficiency of thyroid hormones, the level of triglycerides is significantly higher in both genotypes, which suggests that hypothyroidism plays an essential role in the development of dyslipidemia and NAFLD.

Increased serum levels of high mobility group box 1 protein in patients with autistic disorder.

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Emanuele, Enzo; Boso, Marianna; Brondino, Natascia; Pietra, Stefania; Barale, Francesco; Ucelli di Nemi, Stefania; Politi, Pierluigi

2010-05-30

High mobility group box 1 (HMGB1) is a highly conserved, ubiquitous protein that functions as an activator for inducing the immune response and can be released from neurons after glutamate excitotoxicity. The objective of the present study was to measure serum levels of HMGB1 in patients with autistic disorder and to study their relationship with clinical characteristics. We enrolled 22 adult patients with autistic disorder (mean age: 28.1+/-7.7 years) and 28 age- and gender-matched healthy controls (mean age: 28.7+/-8.1 years). Serum levels of HMGB1 were measured by enzyme-linked immunosorbent assay (ELISA). Compared with healthy subjects, serum levels of HMGB1 were significantly higher in patients with autistic disorder (10.8+/-2.6 ng/mL versus 5.6+/-2.5 ng/mL, respectively, Pautistic disorder. Increased HMGB1 may be a biological correlate of the impaired reciprocal social interactions in this neurodevelopmental disorder. Copyright 2010 Elsevier Inc. All rights reserved.

Differences in UGT1A1, UGT1A7, and UGT1A9 polymorphisms between Uzbek and Japanese populations.

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Maeda, Hiromichi; Hazama, Shoichi; Shavkat, Abdiev; Okamoto, Ken; Oba, Koji; Sakamoto, Junichi; Takahashi, Kenichi; Oka, Masaki; Nakamura, Daisuke; Tsunedomi, Ryouichi; Okayama, Naoko; Mishima, Hideyuki; Kobayashi, Michiya

2014-06-01

Uridine-diphosphate glucuronosyltransferase 1A (UGT1A) is a key enzyme involved in irinotecan metabolism, and polymorphisms in the UGT1A gene are associated with irinotecan-induced toxicity. The aim of this study was to elucidate the allele frequencies of UGT1A polymorphisms in healthy Uzbek volunteers, and to compare them with those of the Japanese population. A total of 97 healthy volunteers from Uzbekistan were enrolled and blood samples were collected from each participant. Genotyping analysis was performed by fragment size analysis for UGT1A1*28, direct sequencing for UGT1A7*3 and UGT1A9*22, and TaqMan assays for UGT1A1*93, UGT1A1*6, UGT1A1*27, UGT1A1*60, and UGT1A7*12. The frequencies of polymorphisms were compared with the Japanese population by using the data previously reported from our study group. When the Uzbek and Japanese populations were compared, heterozygotes or homozygotes for UGT1A1*28, UGT1A1*60, and UGT1A1*93 were significantly more frequent in the Uzbek population (P Japanese population (P Japanese population. A comprehensive study of the influence of UGT1A1 polymorphisms on the risk of irinotecan-induced toxicity is necessary for optimal use of irinotecan treatment.

Convergent-beam electron diffraction study of incommensurately modulated crystals. Pt. 2. (3 + 1)-dimensional space groups

International Nuclear Information System (INIS)

Terauchi, Masami; Takahashi, Mariko; Tanaka, Michiyoshi

1994-01-01

The convergent-beam electron diffraction (CBED) method for determining three-dimensional space groups is extended to the determination of the (3 + 1)-dimensional space groups for one-dimensional incommensurately modulated crystals. It is clarified than an approximate dynamical extinction line appears in the CBED discs of the reflections caused by an incommensurate modulation. The extinction enables the space-group determination of the (3 + 1)-dimensional crystals or the one-dimensional incommensurately modulated crystals. An example of the dynamical extinction line is shown using an incommensurately modulated crystal of Sr 2 Nb 2 O 7 . Tables of the dynamical extinction lines appearing in CBED patterns are given for all the (3 + 1)-dimensional space groups of the incommensurately modulated crystal. (orig.)

STELLAR AND TOTAL BARYON MASS FRACTIONS IN GROUPS AND CLUSTERS SINCE REDSHIFT 1

International Nuclear Information System (INIS)

Giodini, S.; Pierini, D.; Finoguenov, A.; Pratt, G. W.; Boehringer, H.; Leauthaud, A.; Guzzo, L.; Aussel, H.; Bolzonella, M.; Capak, P.; Elvis, M.; Hasinger, G.; Ilbert, O.; Kartaltepe, J. S.; Koekemoer, A. M.; Lilly, S. J.; Massey, R.; Rhodes, J.; Salvato, M.; McCracken, H. J.

2009-01-01

We investigate if the discrepancy between estimates of the total baryon mass fraction obtained from observations of the cosmic microwave background (CMB) and of galaxy groups/clusters persists when a large sample of groups is considered. To this purpose, 91 candidate X-ray groups/poor clusters at redshift 0.1 ≤ z ≤ 1 are selected from the COSMOS 2 deg 2 survey, based only on their X-ray luminosity and extent. This sample is complemented by 27 nearby clusters with a robust, analogous determination of the total and stellar mass inside R 500 . The total sample of 118 groups and clusters with z ≤ 1 spans a range in M 500 of ∼10 13 -10 15 M sun . We find that the stellar mass fraction associated with galaxies at R 500 decreases with increasing total mass as M -0.37±0.04 500 , independent of redshift. Estimating the total gas mass fraction from a recently derived, high-quality scaling relation, the total baryon mass fraction (f stars+gas 500 = f stars 500 + f gas 500 ) is found to increase by ∼25%, when M 500 increases from (M) = 5 x 10 13 M sun to (M) = 7 x 10 14 M sun . After consideration of a plausible contribution due to intracluster light (11%-22% of the total stellar mass) and gas depletion through the hierarchical assembly process (10% of the gas mass), the estimated values of the total baryon mass fraction are still lower than the latest CMB measure of the same quantity (WMAP5), at a significance level of 3.3σ for groups of (M) = 5 x 10 13 M sun . The discrepancy decreases toward higher total masses, such that it is 1σ at (M) = 7 x 10 14 M sun . We discuss this result in terms of nongravitational processes such as feedback and filamentary heating.

Epigenetic regulation of the glucocorticoid receptor promoter 1(7) in adult rats.

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Witzmann, Simone R; Turner, Jonathan D; Mériaux, Sophie B; Meijer, Onno C; Muller, Claude P

2012-11-01

Regulation of glucocorticoid receptor (GR) levels is an important stress adaptation mechanism. Transcription factor Nfgi-a and environmentally induced Gr promoter 1 7 methylation have been implicated in fine-tuning the expression of Gr 1 7 transcripts. Here, we investigated Gr promoter 1 7 methylation and Gr 1 7 expression in adult rats exposed to either acute or chronic stress paradigms. A strong negative correlation was observed between the sum of promoter-wide methylation levels and Gr 1 7 transcript levels, independent of the stressor. Methylation of individual sites did not, however, correlate with transcript levels. This suggested that promoter 1 7 was directly regulated by promoter-wide DNA methylation. Although acute stress increased Ngfi-a expression in the hypothalamic paraventricular nucleus (PVN), Gr 1 7 transcript levels remained unaffected despite low methylation levels. Acute stress had little effect on these low methylation levels, except at four hippocampal CpGs. Chronic stress altered the corticosterone response to an acute stressor. In the adrenal and pituitary glands, but not in the brain, this was accompanied by an increase in methylation levels in orchestrated clusters rather than individual CpGs. PVN methylation levels, unaffected by acute or chronic stress, were significantly more variable within- than between-groups, suggesting that they were instated probably during the perinatal period and represent a pre-established trait. Thus, in addition to the known perinatal programming, the Gr 1 7 promoter is epigenetically regulated by chronic stress in adulthood, and retains promoter-wide tissue-specific plasticity. Differences in methylation susceptibility between the PVN in the perinatal period and the peripheral HPA axis tissues in adulthood may represent an important "trait" vs. "state" regulation of the Gr gene.

Feedback regulation of bile acid synthesis in human liver: Importance of HNF-4α for regulation of CYP7A1

International Nuclear Information System (INIS)

Abrahamsson, Anna; Gustafsson, Ulf; Ellis, Ewa; Nilsson, Lisa-Mari; Sahlin, Staffan; Bjoerkhem, Ingemar; Einarsson, Curt

2005-01-01

A great number of nuclear factors are involved in the negative feedback mechanism regulating bile acid synthesis. There are two major ways for the negative feedback to effect the synthesis; the SHP-dependent, involving FXR, and the SHP-independent way, affecting HNF-4α. We studied 23 patients with gallstone disease. Eight patients were treated with chenodeoxycholic acid, 7 with cholestyramine prior to operation, and 8 served as controls. Liver biopsies were analyzed with Real-time-PCR. In the cholestyramine-treated group mRNA levels of CYP7A1 were increased about 10-fold. Treatment with CDCA decreased the mRNA levels of CYP7A1 by about 70%. The mRNA levels of CYP8B1, CYP27A1, and CYP7B1 were not significantly altered in the treated groups. The analysis of mRNA levels for HNF-4α showed 64% higher levels in the cholestyramine-treated group compared to the controls. These levels showed positive and highly significant correlation to the levels of mRNA of CYP7A1 when studied in all three groups together. FXR, SHP, and LRH-1/FTF were not significantly affected by the different treatments. Our results indicate that when bile acid synthesis is upregulated by cholestyramine treatment the SHP-independent pathway for controlling CYP7A1 transcription dominates over the SHP-dependent pathway

A study of prevalence of Sexually Transmitted Infections & response to syndromic treatment among married women of reproductive age group in rural area of Parol Primary Health Centre under Thane district

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Vibha V. Gosalia

2013-05-01

Full Text Available Objectives To study prevalence of Sexually Transmitted Infections (STIs - symptomatic, clinical & laboratorial& response to syndromic treatment in among STI groups. Design Community based interventional study Setting Rual area-Parol Primary Health Centre(PHC, District Thane, Maharashtra state. Poulation Women of reproductive age groups 15 -45 years Methods Present Community based interventional study was conducted among representative group of 415 women of reproductive age groups who were selected by simple random sampling technique in Parol PHC, District Thane, Maharashtra state. All symptomatic & asymptomatic women were counseled for examination & investigations & given syndromic treatment. Follow-up done to assess impact of syndromic treatment. Main Outcome Prevalence of STI symptomatically was 39%, clinically 32.3% & Laboratorial 26%. After syndromic treatment, prevalence of STIs was significantly reduced. Statistical Analysis Z test Results Of the surveyed women (415, prevalence of STI symptomatically was 39%, clinically 32.3% & Laboratorial 26%. The most common presenting symptom was vaginal discharge (36.4% followed by Burning Micturition (24.7%, Vulval itching (17.3%, Lower abdominal pain (13% & Genital ulcer (8.6%. Clinically, 55.2% women were diagnosed as cervicitis & 44.8% as PID. Laboratorial diagnosed STIs were - vaginal candidiasis 46.3%, Bacterial vaginosis 25%, Trichmoniasis 19.4 %, Genital Herpes 7.4% & HIV 1.9%. After syndromic treatment, prevalence of STIs has statistically significantly reduced. Conclusion Syndromic Rx & health education can definitely reduce STIs.

The 7-azanorbornane nucleus of epibatidine: 7-azabicyclo[2.2.1]heptan-7-ium chloride

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Sergey N. Britvin

2017-09-01

Full Text Available 7-Azabicyclo[2.2.1]heptane (7-azanorbornane is a bridged heterocyclic nucleus found in epibatidine, the alkaloid isolated from the skin of the tropical poison frog Epipedobates tricolor. Since epibatidine is known as one of the most potent acetylcholine nicotinic receptor agonists, a plethora of literature has been devoted to this alkaloid. However, there are no structural data on the unsubstituted 7-azanorbornane, the parent bicyclic ring of epibatidine and its derivatives. We herein present the structural characterization of the 7-azabicyclo[2.2.1]heptane parent ring as its hydrochloride salt, namely 7-azabicyclo[2.2.1]heptan-7-ium chloride, C6H12N+·Cl−. The compete cation is generated by a crystallographic mirror plane with the N atom lying on the mirror, as does the chloride anion. In the crystal, the cations are linked to the anions by N—H...Cl hydrogen bonds, which generate [001] chains.

Synthesis of a novel 'smart' bifunctional chelating agent 1-(2-[beta,D-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex.

Science.gov (United States)

Wardle, Nick J; Herlihy, Amy H; So, Po-Wah; Bell, Jimmy D; Bligh, S W Annie

2007-07-15

A new synthetic pathway to 1-(2-[beta,D-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and 1-(2-[beta,D-galactopyranosyloxy]ethyl)-4,7,10-tris(carboxymethyl)-1, 4,7,10-tetraazacyclododecane (Gal-DO3A) chelating agents was developed involving full hydroxyl- and carboxyl-group protection in precursors to product. Two sequences of cyclen-N-functionalisation were subsequently investigated, one successfully, towards synthesis of the novel 'smart' bifunctional Gal-PA-DO3A-NH2 chelate. The longitudinal proton relaxivities of the neutral [Gd-(Gal-PA-DO3A-NH2)] and [Gd-(Gal-DO3A)] complexes were increased by 28% and 37% in the presence of beta-galactosidase, respectively.

Occurrence of ozone anomalies over cloudy areas in TOMS version-7 level-2 data

Directory of Open Access Journals (Sweden)

X. Liu

2003-01-01

Full Text Available This study investigates anomalous ozone distributions over cloudy areas in Nimbus-7 (N7 and Earth-Probe (EP TOMS version-7 data and analyzes the causes for ozone anomaly formation. A 5°-longitude by 5°-latitude region is defined to contain a Positive Ozone Anomaly (POA or Negative Ozone Anomaly (NOA if the correlation coefficient between total ozone and reflectivity is > 0.5 or -0.5. The average fractions of ozone anomalies among all cloud fields are 31.8 ± 7.7% and 35.8 ± 7.7% in the N7 and EP TOMS data, respectively. Some ozone anomalies are caused by ozone retrieval errors, and others are caused by actual geophysical phenomena. Large cloud-height errors are found in the TOMS version-7 algorithm in comparison to the Temperature Humidity Infrared Radiometer (THIR cloud data. On average, cloud-top pressures are overestimated by ~200 hPa (THIR cloud-top pressure 200 hPa for high-altitude clouds and underestimated by ~150 hPa for low-altitude clouds (THIR cloud-top pressure > 750 hPa. Most tropical NOAs result from negative errors induced by large cloud-height errors, and most tropical POAs are caused by positive errors due to intra-cloud ozone absorption enhancement. However, positive and negative errors offset each other, reducing the ozone anomaly occurrence in TOMS data. Large ozone/reflectivity slopes for mid-latitude POAs show seasonal variation consistent with total ozone fluctuation, indicating that they result mainly from synoptic and planetary wave disturbances. POAs with an occurrence fraction of 30--60% occur in regions of marine stratocumulus off the west coast of South Africa and off the west coast of South America. Both fractions and ozone/reflectivity slopes of these POAs show seasonal variations consistent with that in the tropospheric ozone. About half the ozone/reflectivity slope can be explained by ozone retrieval errors over clear and cloudy areas. The remaining slope may result from there being more ozone production

Microstimulation of area V4 has little effect on spatial attention and on perception of phosphenes evoked in area V1.

Science.gov (United States)

Dagnino, Bruno; Gariel-Mathis, Marie-Alice; Roelfsema, Pieter R

2015-02-01

Previous transcranial magnetic stimulation (TMS) studies suggested that feedback from higher to lower areas of the visual cortex is important for the access of visual information to awareness. However, the influence of cortico-cortical feedback on awareness and the nature of the feedback effects are not yet completely understood. In the present study, we used electrical microstimulation in the visual cortex of monkeys to test the hypothesis that cortico-cortical feedback plays a role in visual awareness. We investigated the interactions between the primary visual cortex (V1) and area V4 by applying microstimulation in both cortical areas at various delays. We report that the monkeys detected the phosphenes produced by V1 microstimulation but subthreshold V4 microstimulation did not influence V1 phosphene detection thresholds. A second experiment examined the influence of V4 microstimulation on the monkeys' ability to detect the dimming of one of three peripheral visual stimuli. Again, microstimulation of a group of V4 neurons failed to modulate the monkeys' perception of a stimulus in their receptive field. We conclude that conditions exist where microstimulation of area V4 has only a limited influence on visual perception. Copyright © 2015 the American Physiological Society.

26 CFR 1.1362-7 - Effective dates.

Science.gov (United States)

2010-04-01

...) INCOME TAXES Small Business Corporations and Their Shareholders § 1.1362-7 Effective dates. (a) In... consideration the statute; its legislative history; the provisions of §§ 18.1362-1 through 18.1362-5 (see 26 CFR... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Effective dates. 1.1362-7 Section 1.1362-7...

Nutrient intake and balancing among female Colobus angolensis palliatus inhabiting structurally distinct forest areas: Effects of group, season, and reproductive state.

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Dunham, Noah T; Rodriguez-Saona, Luis E

2018-06-08

Understanding intraspecific behavioral and dietary variation is critical for assessing primate populations' abilities to persist in habitats characterized by increasing anthropogenic disturbances. While it is evident that some species exhibit considerable dietary flexibility (in terms of species-specific plant parts) in relation to habitat disturbance, it is unclear if primates are characterized by similar variation and flexibility regarding nutrient intake. This study examined the effects of group, season, and reproductive state on nutrient intake and balancing in adult female Colobus angolensis palliatus in the Diani Forest, Kenya. During July 2014 to December 2015, estimates of nutrient intake were recorded for eight females from three groups inhabiting structurally and ecologically distinct forest areas differing in tree species composition and density. There were differences in metabolizable energy (ME) and macronutrient intakes among groups, seasons, and reproductive states. Most notably, females inhabiting one of the more disturbed forest areas consumed less ME and macronutrients compared to females in the more intact forest area. Contrary to prediction, females in early lactation consumed significantly less ME and macronutrients compared to non-lactating and late lactation females. Despite differences in macronutrient intake, the relative contribution of macronutrients to ME were generally more conservative among groups, seasons, and reproductive states. Average daily intake ratios of non-protein energy to available protein ranged from approximately 3.5:1-4.3:1 among groups. These results indicate that female C. a. palliatus demonstrate a consistent nutrient balancing strategy despite significant intergroup differences in consumption of species-specific plant parts. Data from additional colobine species inhabiting different forest types are required to assess the extent to which nutrient balancing is constrained by phylogeny or is more flexible to local

IGF-1/IGF-1R/hsa-let-7c axis regulates the committed differentiation of stem cells from apical papilla

Science.gov (United States)

Ma, Shu; Liu, Genxia; Jin, Lin; Pang, Xiyao; Wang, Yanqiu; Wang, Zilu; Yu, Yan; Yu, Jinhua

2016-01-01

Insulin-like growth factor-1 (IGF-1) and its receptor IGF-1R play a paramount role in tooth/bone formation while hsa-let-7c actively participates in the osteogenic differentiation of mesenchymal stem cells. However, the interaction between IGF-1/IGF-1R and hsa-let-7c on the committed differentiation of stem cells from apical papilla (SCAPs) remains unclear. In this study, human SCAPs were isolated and treated with IGF-1 and hsa-let-7c over/low-expression viruses. The odonto/osteogenic differentiation of these stem cells and the involvement of mitogen-activated protein kinase (MAPK) pathway were subsequently investigated. Alizarin red staining showed that hsa-let-7c low-expression can significantly promote the mineralization of IGF-1 treated SCAPs, while hsa-let-7c over-expression can decrease the calcium deposition of IGF-1 treated SCAPs. Western blot assay and real-time reverse transcription polymerase chain reaction further demonstrated that the expression of odonto/osteogenic markers (ALP, RUNX2/RUNX2, OSX/OSX, OCN/OCN, COL-I/COL-I, DSPP/DSP, and DMP-1/DMP-1) in IGF-1 treated SCAPs were significantly upregulated in Let-7c-low group. On the contrary, hsa-let-7c over-expression could downregulate the expression of these odonto/osteogenic markers. Moreover, western blot assay showed that the JNK and p38 MAPK signaling pathways were activated in Let-7c-low SCAPs but inhibited in Let-7c-over SCAPs. Together, the IGF-1/IGF-1R/hsa-let-7c axis can control the odonto/osteogenic differentiation of IGF-1-treated SCAPs via the regulation of JNK and p38 MAPK signaling pathways. PMID:27833148

Evaluation of Countermeasures Effectiveness in a Radioactively Contaminated Urban Area Using METRO-K : The Implementation of Scenarios Designed by the EMRAS II Urban Areas Working Group

International Nuclear Information System (INIS)

Hwang, Won Tae; Jeong, Hae Sun; Jeong, Hyo Joon; Kim, Eun Han; Han, Moon Hee

2012-01-01

The Urban Areas Working Group within the EMRAS-2 (Environmental Modelling for RAdiation Safety, Phase 2), which has been supported by the IAEA (International Atomic Energy Agency), has designed some types of accidental scenarios to test and improve the capabilities of models used for evaluation of radioactive contamination in urban areas. For the comparison of the results predicted from the different models, the absorbed doses in air were analyzed as a function of time following the accident with consideration of countermeasures to be taken. Two kinds of considerations were performed to find the dependency of the predicted results. One is the 'accidental season', i.e. summer and winter, in which an event of radioactive contamination takes place in a specified urban area. Likewise, the 'rainfall intensity' on the day of an event was also considered with the option of 1) no rain, 2) light rain, and 3) heavy rain. The results predicted using a domestic model of METRO-K have been submitted to the Urban Areas Working Group for the intercomparison with those of other models. In this study, as a part of these results using METRO-K, the countermeasures effectiveness in terms of dose reduction was analyzed and presented for the ground floor of a 24-story business building in a specified urban area. As a result, it was found that the countermeasures effectiveness is distinctly dependent on the rainfall intensity on the day of an event, and season when an event takes place. It is related to the different deposition amount of the radionuclides to the surfaces and different behavior on the surfaces following a deposition, and different effectiveness from countermeasures. In conclusion, a selection of appropriate countermeasures with consideration of various environmental conditions may be important to minimize and optimize the socio-economic costs as well as radiation-induced health detriments.

Lumbar paraspinal muscle transverse area and symmetry in dogs with and without degenerative lumbosacral stenosis.

Science.gov (United States)

Henderson, A L; Hecht, S; Millis, D L

2015-10-01

To investigate whether dogs with degenerative lumbosacral stenosis have decreased lumbar paraspinal muscle transverse area and symmetry compared with control dogs. Retrospective cross-sectional study comparing muscles in transverse T2-weighted magnetic resonance images for nine dogs with and nine dogs without degenerative -lumbosacral stenosis. Mean transverse area was measured for the lumbar multifidus and sacrocaudalis dorsalis lateralis muscles bilaterally and the L7 vertebral body at the level of the caudal endplate. Transverse areas of both muscle groups relative to L7 and asymmetry indices were compared between study populations using independent t tests. Mean muscle-to-L7 transverse area ratios were significantly smaller in the degenerative lumbosacral stenosis group compared with those in the control group in both lumbar multifidus (0·84 ±0·26 versus 1·09 ±0·25; P=0·027) and sacrocaudalis dorsalis lateralis (0·5 ±0·15 versus 0·68 ±0·12; P=0·005) muscles. Mean asymmetry indices were higher for both muscles in the group with degenerative lumbosacral stenosis than in the control group, but highly variable and the difference was not statistically significant. These findings suggest that dogs with degenerative lumbosacral stenosis have decreased lumbar paraspinal muscle mass that may be a cause or consequence of the -syndrome. Understanding altered paraspinal muscle characteristics may improve understanding of the -pathophysiology and management options for degenerative lumbosacral stenosis. © 2015 British Small Animal Veterinary Association.

Angiotensin-(1-7)/Mas axis integrity is required for the expression of object recognition memory.

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Lazaroni, Thiago L N; Raslan, Ana Cláudia S; Fontes, Walkiria R P; de Oliveira, Marilene L; Bader, Michael; Alenina, Natalia; Moraes, Márcio F D; Dos Santos, Robson A; Pereira, Grace S

2012-01-01

It has been shown that the brain has its own intrinsic renin-angiotensin system (RAS) and angiotensin-(1-7) (Ang-(1-7)) is particularly interesting, because it appears to counterbalance most of the Ang II effects. Ang-(1-7) exerts its biological function through activation of the G-protein-coupled receptor Mas. Interestingly, hippocampus is one of the regions with higher expression of Mas. However, the role of Ang-(1-7)/Mas axis in hippocampus-dependent memories is still poorly understood. Here we demonstrated that Mas ablation, as well as the blockade of Mas in the CA1-hippocampus, impaired object recognition memory (ORM). We also demonstrated that the blockade of Ang II receptors AT1, but not AT2, recovers ORM impairment of Mas-deficient mice. Considering that high concentrations of Ang-(1-7) may activate AT1 receptors, nonspecifically, we evaluate the levels of Ang-(1-7) and its main precursors Ang I and Ang II in the hippocampus of Mas-deficient mice. The Ang I and Ang II levels are unaltered in the whole hipocampus of MasKo. However, Ang-(1-7) concentration is increased in the whole hippocampus of MasKo mice, as well as in the CA1 area. Taken together, our findings suggest that the functionality of the Ang-(1-7)/Mas axis is essential for normal ORM processing. Copyright © 2011 Elsevier Inc. All rights reserved.

Ozone Nonattainment Areas - 1 Hour

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U.S. Environmental Protection Agency — This data layer identifies areas in the U.S. where air pollution levels have not met the National Ambient Air Quality Standards (NAAQS) for Ozone - 1hour (Legacy...

The Co-III-C bond in (1-thia-4,7-diazacyclodecyl-kappa N-3(4),N-7,C-10)(1,4,7-triazacyclononane-kappa N-3(1),N-4,N-7)-cobalt(III) dithionate hydrate

DEFF Research Database (Denmark)

Harris, Pernille; Kofod, P.; Song, Y.S.

2003-01-01

In the title compound, [Co(C6H15N3)(C7H15N2S)]S2O6.H2O, the Co-C bond distance is 1.9930 (13) Angstrom, which is shorter than for related compounds with the linear 1,6-diamino-3-thiahexan-4-ide anion in place of the macrocyclic 1-thia-4,7-diazacyclodecan-8-ide anion. The coordinated carbanion pro...... produces an elongation of 0.102 (7) Angstrom of the Co-N bond to the 1,4,7-triazacyclononane N atom in the trans position. This relatively small trans influence is presumably a result of the triamine ligand forming strong bonds to the Co-III atom....

Feasibility For Measuring Transverse Area Ratios And Asymmetry Of Lumbosacral Region Paraspinal Muscles In Working Dogs Using Computed Tomography

Directory of Open Access Journals (Sweden)

Bethany eCain

2016-05-01

Full Text Available Objectives: Describe computed tomographic (CT anatomy of canine lumbosacral paraspinal muscles, a method for measuring paraspinal muscle transverse area ratios and asymmetry using CT, and application of this method in a small sample of working dogs with versus without lumbosacral pain.Methods: Published anatomy references and atlases were reviewed and discrepancies resolved by examination of anatomic specimens and multi-planar reformatted images to describe transverse CT anatomy of lumbosacral region paraspinal muscles. Sixteen Belgian malinois military working dogs were retrospectively recruited and assigned to lumbosacral pain positive versus negative groups based on medical record entries. A single observer unaware of dog group measured CT transverse areas of paraspinal muscles and adjacent vertebral bodies, in triplicate, for L5-S1 vertebral locations. A statistician compared muscle transverse area ratios and asymmetry at each vertebral location between groups. Results: The relative co-efficient of variation for triplicate CT area measurements averaged 2.15% (N=16. Multifidus lumborum (L6-7, psoas/iliopsoas (L5-6, L6-7, and sacrocaudalis dorsalis lateralis (L6-7, L7-S1 transverse area ratios were significantly smaller in dogs with lumbosacral pain (n=11 vs. without lumbosacral pain (n=5 (p< 0.05. Muscle asymmetry values were not significantly greater in dogs with vs. without lumbosacral pain. Clinical relevance: Computed tomographic morphometry of lumbosacral region paraspinal muscles is a feasible objective method for use in future evidence-based research studies in working dogs. Potential future research applications include determining whether decreased paraspinal muscle area ratios and/or increased paraspinal muscle asymmetry could be used as markers for preclinical lumbosacral pain in stoic dogs or risk factors for other injuries in high performance canine athletes; or determining whether core muscle strengthening exercise prescriptions

Growth of epitaxially oriented Ag nanoislands on air-oxidized Si(1 1 1)-(7 × 7) surfaces: Influence of short-range order on the substrate

International Nuclear Information System (INIS)

Roy, Anupam; Bhattacharjee, K.; Ghatak, J.; Dev, B.N.

2012-01-01

Clean Si(1 1 1)-(7 × 7) surfaces, followed by air-exposure, have been investigated by reflection high-energy electron diffraction (RHEED) and scanning tunneling microscopy (STM). Fourier transforms (FTs) of STM images show the presence of short-range (7 × 7) order on the air-oxidized surface. Comparison with FTs of STM images from a clean Si(1 1 1)-(7 × 7) surface shows that only the 1/7th order spots are present on the air-oxidized surface. The oxide layer is ∼2-3 nm thick, as revealed by cross-sectional transmission electron microscopy (XTEM). Growth of Ag islands on these air-oxidized Si(1 1 1)-(7 × 7) surfaces has been investigated by in situ RHEED and STM and ex situ XTEM and scanning electron microscopy. Ag deposition at room temperature leads to the growth of randomly oriented Ag islands while preferred orientation evolves when Ag is deposited at higher substrate temperatures. For deposition at 550 °C face centered cubic Ag nanoislands grow with a predominant epitaxial orientation [11 ¯ 0] Ag ||[11 ¯ 0] Si , (1 1 1) Ag || (1 1 1) Si along with its twin [1 ¯ 10] Ag ||[11 ¯ 0] Si , (1 1 1) Ag || (1 1 1) Si , as observed for epitaxial growth of Ag on Si(1 1 1) surfaces. The twins are thus rotated by a 180° rotation of the Ag unit cell about the Si[1 1 1] axis. It is intriguing that Ag nanoislands follow an epitaxial relationship with the Si(1 1 1) substrate in spite of the presence of a 2-3 nm thick oxide layer between Ag and Si. Apparently the short-range order on the oxide surface influences the crystallographic orientation of the Ag nanoislands.

Finding Risk Groups by Optimizing Artificial Neural Networks on the Area under the Survival Curve Using Genetic Algorithms.

Science.gov (United States)

Kalderstam, Jonas; Edén, Patrik; Ohlsson, Mattias

2015-01-01

We investigate a new method to place patients into risk groups in censored survival data. Properties such as median survival time, and end survival rate, are implicitly improved by optimizing the area under the survival curve. Artificial neural networks (ANN) are trained to either maximize or minimize this area using a genetic algorithm, and combined into an ensemble to predict one of low, intermediate, or high risk groups. Estimated patient risk can influence treatment choices, and is important for study stratification. A common approach is to sort the patients according to a prognostic index and then group them along the quartile limits. The Cox proportional hazards model (Cox) is one example of this approach. Another method of doing risk grouping is recursive partitioning (Rpart), which constructs a decision tree where each branch point maximizes the statistical separation between the groups. ANN, Cox, and Rpart are compared on five publicly available data sets with varying properties. Cross-validation, as well as separate test sets, are used to validate the models. Results on the test sets show comparable performance, except for the smallest data set where Rpart's predicted risk groups turn out to be inverted, an example of crossing survival curves. Cross-validation shows that all three models exhibit crossing of some survival curves on this small data set but that the ANN model manages the best separation of groups in terms of median survival time before such crossings. The conclusion is that optimizing the area under the survival curve is a viable approach to identify risk groups. Training ANNs to optimize this area combines two key strengths from both prognostic indices and Rpart. First, a desired minimum group size can be specified, as for a prognostic index. Second, the ability to utilize non-linear effects among the covariates, which Rpart is also able to do.

The metal chaperone Atox1 regulates the activity of the human copper transporter ATP7B by modulating domain dynamics.

Science.gov (United States)

Yu, Corey H; Yang, Nan; Bothe, Jameson; Tonelli, Marco; Nokhrin, Sergiy; Dolgova, Natalia V; Braiterman, Lelita; Lutsenko, Svetlana; Dmitriev, Oleg Y

2017-11-03

The human transporter ATP7B delivers copper to the biosynthetic pathways and maintains copper homeostasis in the liver. Mutations in ATP7B cause the potentially fatal hepatoneurological disorder Wilson disease. The activity and intracellular localization of ATP7B are regulated by copper, but the molecular mechanism of this regulation is largely unknown. We show that the copper chaperone Atox1, which delivers copper to ATP7B, and the group of the first three metal-binding domains (MBD1-3) are central to the activity regulation of ATP7B. Atox1-Cu binding to ATP7B changes domain dynamics and interactions within the MBD1-3 group and activates ATP hydrolysis. To understand the mechanism linking Atox1-MBD interactions and enzyme activity, we have determined the MBD1-3 conformational space using small angle X-ray scattering and identified changes in MBD dynamics caused by apo -Atox1 and Atox1-Cu by solution NMR. The results show that copper transfer from Atox1 decreases domain interactions within the MBD1-3 group and increases the mobility of the individual domains. The N-terminal segment of MBD1-3 was found to interact with the nucleotide-binding domain of ATP7B, thus physically coupling the domains involved in copper binding and those involved in ATP hydrolysis. Taken together, the data suggest a regulatory mechanism in which Atox1-mediated copper transfer activates ATP7B by releasing inhibitory constraints through increased freedom of MBD1-3 motions. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

MODICO, 1-D Time-Dependent 1 Group, 2 Group Neutron Diffusion with Delayed Neutron Precursors

International Nuclear Information System (INIS)

Camiciola, P.; Cundari, D.; Montagnini, B.

1992-01-01

1 - Description of program or function: The program solves the 1-D time-dependent one and two group coarse-mesh neutron diffusion equations, coupled with the equations for the delayed-neutron precursor, in plane geometry. 2 - Method of solution: The program is based on a simple coarse-mesh cubic approximation formula for the spatial behaviour of the flux inside each interval. An implicit scheme (the time-integrated method) is used for the advancement of the solution. The resulting (block three-diagonal) matrix is inverted at each time step by Thomas' method. 3 - Restrictions on the complexity of the problem: Number of coarse- mesh intervals LE 80; number of material regions LE 10; number of delayed-neutron precursor groups LE 10. Typical mesh sizes range from 5 cm to 20 cm; typical step length (non-prompt critical transients) ranges from 0.005 to 0.1 seconds

COMBINE7.1 - A Portable ENDF/B-VII.0 Based Neutron Spectrum and Cross-Section Generation Program

Energy Technology Data Exchange (ETDEWEB)

Woo Y. Yoon; David W. Nigg

2009-08-01

COMBINE7.1 is a FORTRAN 90 computer code that generates multigroup neutron constants for use in the deterministic diffusion and transport theory neutronics analysis. The cross-section database used by COMBINE7.1 is derived from the Evaluated Nuclear Data Files (ENDF/B-VII.0). The neutron energy range covered is from 20 MeV to 1.0E-5 eV. The Los Alamos National Laboratory NJOY code is used as the processing code to generate a 167 fine-group cross-section library in MATXS format for Bondarenko self-shielding treatment. Resolved resonance parameters are extracted from ENDF/B-VII.0 File 2 for a separate library to be used in an alternate Nordheim self-shielding treatment in the resolved resonance energy range. The equations solved for energy dependent neutron spectrum in the 167 fine-group structure are the B-3 or B-1 approximations to the transport equation. The fine group cross sections needed for the spectrum calculation are first prepared by Bondarenko self-shielding interpolation in terms of background cross section and temperature. The geometric lump effect, when present, is accounted for by augmenting the background cross section. Nordheim self-shielded fine group cross sections for a material having resolved resonance parameters overwrite correspondingly the existing self-shielded fine group cross sections when this option is used. The fine group cross sections in the thermal energy range are replaced by those self-shielded with the Amouyal/Benoist/Horowitz method in the three region geometry when this option is requested. COMBINE7.1 coalesces fine group cross sections into broad group macroscopic and microscopic constants. The coalescing is performed by utilizing fine-group fluxes and/or currents obtained by spectrum calculation as the weighting functions. The multigroup constant may be output in any of several standard formats including ANISN 14** free format, CCCC ISOTXS format, and AMPX working library format. ANISN-PC, a one-dimensional, discrete

COMBINE7.1 - A Portable ENDF/B-VII.0 Based Neutron Spectrum and Cross-Section Generation Program

International Nuclear Information System (INIS)

Yoon, Woo Y.; Nigg, David W.

2009-01-01

COMBINE7.1 is a FORTRAN 90 computer code that generates multigroup neutron constants for use in the deterministic diffusion and transport theory neutronics analysis. The cross-section database used by COMBINE7.1 is derived from the Evaluated Nuclear Data Files (ENDF/B-VII.0). The neutron energy range covered is from 20 MeV to 1.0E-5 eV. The Los Alamos National Laboratory NJOY code is used as the processing code to generate a 167 fine-group cross-section library in MATXS format for Bondarenko self-shielding treatment. Resolved resonance parameters are extracted from ENDF/B-VII.0 File 2 for a separate library to be used in an alternate Nordheim self-shielding treatment in the resolved resonance energy range. The equations solved for energy dependent neutron spectrum in the 167 fine-group structure are the B-3 or B-1 approximations to the transport equation. The fine group cross sections needed for the spectrum calculation are first prepared by Bondarenko self-shielding interpolation in terms of background cross section and temperature. The geometric lump effect, when present, is accounted for by augmenting the background cross section. Nordheim self-shielded fine group cross sections for a material having resolved resonance parameters overwrite correspondingly the existing self-shielded fine group cross sections when this option is used. The fine group cross sections in the thermal energy range are replaced by those self-shielded with the Amouyal/Benoist/Horowitz method in the three region geometry when this option is requested. COMBINE7.1 coalesces fine group cross sections into broad group macroscopic and microscopic constants. The coalescing is performed by utilizing fine-group fluxes and/or currents obtained by spectrum calculation as the weighting functions. The multigroup constant may be output in any of several standard formats including ANISN 14** free format, CCCC ISOTXS format, and AMPX working library format. ANISN-PC, a one-dimensional, discrete

Prevalence of hemoglobinopathy, ABO and rhesus blood groups in rural areas of West Bengal, India.

Science.gov (United States)

Mondal, Bikash; Maiti, Soumyajit; Biswas, Biplab Kumar; Ghosh, Debidas; Paul, Shyamapada

2012-08-01

Hemoglobinopathies are a group of inherited disorders of hemoglobin synthesis. It could be formed a fatal scenario in concern of lacking of actual information. Beside this, ABO and Rh blood grouping are also important matter in transfusion and forensic medicine and to reduce new born hemolytic disease (NHD). The spectrum and prevalence of various hemoglobinopathies, ABO and rhesus (Rh) blood groups was screened among patients who visited B.S. Medical College and Hospital, Bankura, West Bengal, India. This study was carried out on 958 patients of different ages ranging from child to adults from January to June 2011. High-performance liquid chromatography (HPLC), complete blood count (CBC) and hemagglutination technique were performed for the assessment of abnormal hemoglobin variants, ABO and Rh blood groups, respectively. Results from this study had been shown that there was high prevalence of hemoglobinpathies (27.35%) where β-thalassemia in heterozygous state occurred more frequent than other hemoglobinopathies. Out of 958 patients, 72.65% were HbAA and 27.35% were hemoglobinopathies individuals where 17.64% β-thalassemia heterozygous, 2.92% β-thalassemia homozygous, 3.86% HbAE, 1.15% HbAS trait, 1.25% HbE-β thalassemia trait and 0.52% HbS-β thalassemia trait were found. No incidence of HbSS, HbSC, HbCC, HbD and other variants of hemoglobinpathies were observed. The gene frequencies with respect to ABO systems had been shown as O > B > A > AB. Blood group O was the highest (35.8%) and the least percentage distribution was blood group AB (6.68%). Rhesus positive (Rh+) were 97.7%, while the remaining was 2.3% Rhesus negative (Rh-). The frequencies of A(+), B(+), AB(+,) and O(+) blood groups were 22.44%, 33.61%, 6.58%, and 35.07%, respectively. Remarkable percentages of hemoglobinopathies were prevalent from the present study. An extensive screening of the population is needed to assess the prevalence of hemoglobinopathies, which will help in identification of

Polymorphisms of UGT1A1*6, UGT1A1*27 & UGT1A1*28 in three major ethnic groups from Malaysia.

Science.gov (United States)

Teh, L K; Hashim, H; Zakaria, Z A; Salleh, M Z

2012-08-01

Genetic polymorphisms of uridine diphosphate glucuronyltransferase 1A1 (UGT1A1) have been associated with a wide variation of responses among patients prescribed with irinotecan. Lack of this enzyme is known to be associated with a high incidence of severe toxicity. The objective of this study was to investigate the prevalence of three different variants of UGT1A1 (UGT1A1*6, UGT1A1*27 and UGT1A1*28), which are associated with reduced enzyme activity and increased irinotecan toxicity, in the three main ethnic groups in Malaysia (Malays, Chinese and Indians). A total of 306 healthy unrelated volunteers were screened for UGT1A1*28, UGT1A1*6 and UGT1A1*27. Blood samples (5 ml) were obtained from each subject and DNA was extracted. PCR based methods were designed and validated for detection of UGT1A1*, UUGT1A1*27 and UUGT1A1*28. Direct DNA sequencing was performed to validate the results of randomly selected samples. Malays and Indian have two-fold higher frequency of homozygous of UGT1A1*28 (7TA/7TA) which was 8 and 8.8 per cent, respectively compared to the Chinese (4.9%). However, the distribution of UGT1A1*6 and UGT1A1*27 showed no significant differences among them. UGT1A1*27 which has not been detected in Caucasian and African American population, was found in the Malaysian Malays (3.33%) and Malaysian Chinese (2.0%). There was interethnic variability in the frequency of UGT1A1*28 in the Malaysian population. Our results suggest that genotyping of UUGT1A1*6, UGT1A1*28 and UGT1A1*27 need to be performed before patients are prescribed with irinotecan due to their high prevalence of allelic variant which could lead to adverse drug reaction.

Source document for waste area groupings at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

Osborne, P.L.; Kuhaida, A.J., Jr.

1996-09-01

This document serves as a source document for Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) and other types of documents developed for and pertaining to Environmental Restoration (ER) Program activities at Oak Ridge National Laboratory (ORNL). It contains descriptions of the (1) regulatory requirements for the ORR ER Program, (2) Oak Ridge Reservation (ORR) ER Program, (3) ORNL site history and characterization, and (4) history and characterization of Waste Area Groupings (WAGS) 1-20. This document was created to save time, effort, and money for persons and organizations drafting documents for the ER Program and to improve consistency in the documents prepared for the program. By eliminating the repetitious use of selected information about the program, this document will help reduce the time and costs associated with producing program documents. By serving as a benchmark for selected information about the ER Program, this reference will help ensure that information presented in future documents is accurate and complete

Fire Hazards Analysis for the 200 Area Interim Storage Area

International Nuclear Information System (INIS)

JOHNSON, D.M.

2000-01-01

This documents the Fire Hazards Analysis (FHA) for the 200 Area Interim Storage Area. The Interim Storage Cask, Rad-Vault, and NAC-1 Cask are analyzed for fire hazards and the 200 Area Interim Storage Area is assessed according to HNF-PRO-350 and the objectives of DOE Order 5480 7A. This FHA addresses the potential fire hazards associated with the Interim Storage Area (ISA) facility in accordance with the requirements of DOE Order 5480 7A. It is intended to assess the risk from fire to ensure there are no undue fire hazards to site personnel and the public and to ensure property damage potential from fire is within acceptable limits. This FHA will be in the form of a graded approach commensurate with the complexity of the structure or area and the associated fire hazards

Preliminary site description Forsmark area - version 1.1

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-03-01

This report presents the interim version (model version 1.1) of the preliminary Site Descriptive Model for Forsmark. The basis for this interim version is quality-assured, geoscientific and ecological field data from Forsmark that were available in the SKB databases SICADA and GIS at April 30, 2003 as well as version 0 of the Site Descriptive Model. The new data acquired during the initial site investigation phase to the date of data freeze 1.1 constitute the basis for the updating of version 0 to version 1.1. These data originate from surface investigations on the candidate area with its regional environment and from drilling and investigations in boreholes. The surface-based data sets were rather extensive whereas the data sets from boreholes were limited to information from one 1,000 m deep cored borehole (KFM01A) and eight 150 to 200 m deep percussion-drilled boreholes in the Forsmark candidate area. Discipline specific models are developed for a selected regional and local model volume and these are then integrated into a site description. The current methodologies for developing the discipline specific models and the integration of these are documented in methodology reports or strategy reports. In the present work, the guidelines given in those reports were followed to the extent possible with the data and information available at the time for data freeze for model version 1.1. Compared with version 0 there are considerable additional features in the version 1.1, especially in the geological description and in the description of the near surface. The geological models of lithology and deformation zones are based on borehole information and much higher resolution surface data. The existence of highly fractured sub-horizontal zones has been verified and these are now part of the model of the deformation zones. A discrete fracture network (DFN) model has also been developed. The rock mechanics model is based on strength information from SFR and an empirical

In situ crystallization of the linear alkynes CnH2n–2 (n = 7, 8, 9, 10)

DEFF Research Database (Denmark)

Bond, Andrew; Davies, John E

2014-01-01

A manual in situ crystallization technique is described, for application on a κ-geometry area-detector instrument. The technique has been applied to grow crystals of some linear alkynes: 1-heptyne, 1-octyne, 1-nonyne and 1-decyne, Cn H2n–2 (n=7, 8, 9, 10). The structures with odd n (1-heptyne and 1...... 5.7×7.2 Å, identical to the layers present in the previously published structures of 1,7-octadiyne and 1,9-decadiyne. The structures differ where the methyl groups meet, giving systematically greater packing efficiency for 1-heptyne and 1-nonyne, compared to 1-octyne and 1-decyne. This systematic...

Group-III vacancy induced InxGa1-xAs quantum dot interdiffusion

International Nuclear Information System (INIS)

Djie, H. S.; Wang, D.-N.; Ooi, B. S.; Hwang, J. C. M.; Gunawan, O.

2006-01-01

The impact of group-III vacancy diffusion, generated during dielectric cap induced intermixing, on the energy state transition and the inhomogeneity reduction in the InGaAs/GaAs quantum-dot structure is investigated. We use a three-dimensional quantum-dot diffusion model and photoluminescence data to determine the thermal and the interdiffusion properties of the quantum dot. The band gap energy variation related to the dot uniformity is found to be dominantly affected by the height fluctuation. A group-III vacancies migration energy H m for InGaAs quantum dots of 1.7 eV was deduced. This result is similar to the value obtained from the bulk and GaAs/AlGaAs quantum-well materials confirming the role of SiO 2 capping enhanced group-III vacancy induced interdiffusion in the InGaAs quantum dots

Hanford Environmental Information System (HEIS). Volume 7: Sample and Data Tracking subject area

International Nuclear Information System (INIS)

1994-06-01

The Hanford Environmental Information System (HEIS) Sample and Data Tracking subject area allows insertion of tracking information into a central repository where the data is immediately available for viewing. For example, a technical coordinator is able to view the current status of a particular sampling effort, from sample collection to data package validation dates. Four major types of data comprise the Sample and Data Tracking subject area: data about the mechanisms that groups a set of samples for a particular sampling effort; data about how constituents are grouped and assigned to a sample; data about when, where, and how samples are sent to a laboratory for analysis; and data bout the status of a sample's constituent analysis requirements, i.e., whether the analysis results have been returned from the laboratory

7 CFR 1.322 - Discovery.

Science.gov (United States)

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Discovery. 1.322 Section 1.322 Agriculture Office of... Under the Program Fraud Civil Remedies Act of 1986 § 1.322 Discovery. (a) The following types of discovery are authorized: (1) Requests for production, inspection and photocopying of documents; (2...

WNT7A/?-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer

OpenAIRE

King, Mandy L.; Lindberg, Mallory E.; Stodden, Genna R.; Okuda, Hiroshi; Ebers, Steven D.; Johnson, Alyssa; Montag, Anthony; Lengyel, Ernst; MacLean, James A.; Hayashi, Kanako

2014-01-01

We previously characterized the link between WNT7A and the progression of ovarian cancer. Other groups have identified FGF1 as a relevant risk factor in ovarian cancer. Here, we show a linkage between these two signaling pathways that may be exploited to improve treatment and prognosis of patients with ovarian cancer. High expression of WNT7A and FGF1 are correlated in ovarian carcinomas and poor overall patient survival. A chromatin immunoprecipitation assay demonstrated that WNT7A/?-catenin...

Rhodium-Catalyzed Regioselective C7-Olefination of Indazoles Using an N-Amide Directing Group.

Science.gov (United States)

Guo, Lei; Chen, Yanyu; Zhang, Rong; Peng, Qiujun; Xu, Lanting; Pan, Xianhua

2017-02-01

A rhodium-catalyzed regioselective C-H olefination of indazole is described. This protocol relies on the use of an efficient and removable N,N-diisopropylcarbamoyl directing group, which offers facile access to C7-olefinated indazoles with high regioselectivity, ample substrate scope and broad functional group tolerance. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Linking retinotopic fMRI mapping and anatomical probability maps of human occipital areas V1 and V2.

Science.gov (United States)

Wohlschläger, A M; Specht, K; Lie, C; Mohlberg, H; Wohlschläger, A; Bente, K; Pietrzyk, U; Stöcker, T; Zilles, K; Amunts, K; Fink, G R

2005-05-15

Using functional MRI, we characterized field sign maps of the occipital cortex and created three-dimensional maps of these areas. By averaging the individual maps into group maps, probability maps of functionally defined V1 or V2 were determined and compared to anatomical probability maps of Brodmann areas BA17 and BA18 derived from cytoarchitectonic analysis (Amunts, K., Malikovic, A., Mohlberg, H., Schormann, T., Zilles, K., 2000. Brodmann's areas 17 and 18 brought into stereotaxic space-where and how variable? NeuroImage 11, 66-84). Comparison of areas BA17/V1 and BA18/V2 revealed good agreement of the anatomical and functional probability maps. Taking into account that our functional stimulation (due to constraints of the visual angle of stimulation achievable in the MR scanner) only identified parts of V1 and V2, for statistical evaluation of the spatial correlation of V1 and BA17, or V2 and BA18, respectively, the a priori measure kappa was calculated testing the hypothesis that a region can only be part of functionally defined V1 or V2 if it is also in anatomically defined BA17 or BA18, respectively. kappa = 1 means the hypothesis is fully true, kappa = 0 means functionally and anatomically defined visual areas are independent. When applying this measure to the probability maps, kappa was equal to 0.84 for both V1/BA17 and V2/BA18. The data thus show a good correspondence of functionally and anatomically derived segregations of early visual processing areas and serve as a basis for employing anatomical probability maps of V1 and V2 in group analyses to characterize functional activations of early visual processing areas.

Astrophysical S factor for the 7Li(d,n0)8Be and 7Li(d,n1)8Be reactions

International Nuclear Information System (INIS)

Sabourov, A.; Ahmed, M.W.; Blackston, M.A.; Crowell, A.S.; Howell, C.R.; Perdue, B.A.; Sabourov, K.; Tonchev, A.; Weller, H.R.; Prior, R.M.; Spraker, M.C.

2006-01-01

The absolute astrophysical S factor and cross section for the 7 Li(d,n 0 ) 8 Be and 7 Li(d,n 1 ) 8 Be reactions have been determined using deuteron beams with energies between 45 and 80 keV. The slope of the S factor is consistent with zero in the n 0 case but is slightly negative in the n 1 case. The S factor for the sum of both neutron groups at c.m. energies below 70 keV is S(E)=5400(±1500)-37(±21)E keV b, where E is the c.m. energy in keV

Capture-recapture of white-tailed deer using DNA from fecal pellet-groups

Science.gov (United States)

Goode, Matthew J; Beaver, Jared T; Muller, Lisa I; Clark, Joseph D.; van Manen, Frank T.; Harper, Craig T; Basinger, P Seth

2014-01-01

Traditional methods for estimating white-tailed deer population size and density are affected by behavioral biases, poor detection in densely forested areas, and invalid techniques for estimating effective trapping area. We evaluated a noninvasive method of capture—recapture for white-tailed deer (Odocoileus virginianus) density estimation using DNA extracted from fecal pellets as an individual marker and for gender determination, coupled with a spatial detection function to estimate density (spatially explicit capture—recapture, SECR). We collected pellet groups from 11 to 22 January 2010 at randomly selected sites within a 1-km2 area located on Arnold Air Force Base in Coffee and Franklin counties, Tennessee. We searched 703 10-m radius plots and collected 352 pellet-group samples from 197 plots over five two-day sampling intervals. Using only the freshest pellets we recorded 140 captures of 33 different animals (15M:18F). Male and female densities were 1.9 (SE = 0.8) and 3.8 (SE = 1.3) deer km-2, or a total density of 5.8 deer km-2 (14.9 deer mile-2). Population size was 20.8 (SE = 7.6) over a 360-ha area, and sex ratio was 1.0 M: 2.0 F (SE = 0.71). We found DNA sampling from pellet groups improved deer abundance, density and sex ratio estimates in contiguous landscapes which could be used to track responses to harvest or other management actions.

Rapid eye movement (REM sleep deprivation reduces rat frontal cortex acetylcholinesterase (EC 3.1.1.7 activity

Directory of Open Access Journals (Sweden)

Camarini R.

1997-01-01

Full Text Available Rapid eye movement (REM sleep deprivation induces several behavioral changes. Among these, a decrease in yawning behavior produced by low doses of cholinergic agonists is observed which indicates a change in brain cholinergic neurotransmission after REM sleep deprivation. Acetylcholinesterase (Achase controls acetylcholine (Ach availability in the synaptic cleft. Therefore, altered Achase activity may lead to a change in Ach availability at the receptor level which, in turn, may result in modification of cholinergic neurotransmission. To determine if REM sleep deprivation would change the activity of Achase, male Wistar rats, 3 months old, weighing 250-300 g, were deprived of REM sleep for 96 h by the flower-pot technique (N = 12. Two additional groups, a home-cage control (N = 6 and a large platform control (N = 6, were also used. Achase was measured in the frontal cortex using two different methods to obtain the enzyme activity. One method consisted of the obtention of total (900 g supernatant, membrane-bound (100,000 g pellet and soluble (100,000 g supernatant Achase, and the other method consisted of the obtention of a fraction (40,000 g pellet enriched in synaptic membrane-bound enzyme. In both preparations, REM sleep deprivation induced a significant decrease in rat frontal cortex Achase activity when compared to both home-cage and large platform controls. REM sleep deprivation induced a significant decrease of 16% in the membrane-bound Achase activity (nmol thiocholine formed min-1 mg protein-1 in the 100,000 g pellet enzyme preparation (home-cage group 152.1 ± 5.7, large platform group 152.7 ± 24.9 and REM sleep-deprived group 127.9 ± 13.8. There was no difference in the soluble enzyme activity. REM sleep deprivation also induced a significant decrease of 20% in the enriched synaptic membrane-bound Achase activity (home-cage group 126.4 ± 21.5, large platform group 127.8 ± 20.4, REM sleep-deprived group 102.8 ± 14.2. Our results

Environmental Modelling of Remediation of Urban Contaminated Areas. Report of the Urban Remediation Working Group of EMRAS Theme 2

International Nuclear Information System (INIS)

2012-01-01

The Urban Remediation Working Group of the International Atomic Energy Agency's EMRAS (Environmental Modelling for RAdiation Safety) programme was concerned with remediation assessment for urban areas contaminated with dispersed radionuclides. Types of events that could result in dispersal or deposition of radionuclides in an urban situation include both intentional and unintentional events, and releases could range from major events involving a nuclear facility to small events such as a transportation accident. The primary objective of the Urban Remediation Working Group was (1) to test and improve the prediction of dose rates and cumulative doses to humans for urban areas contaminated with dispersed radionuclides, including prediction of changes in radionuclide concentrations or dose rates as a function of location and time; (2) to identify the most important pathways for human exposure; and (3) to predict the reduction in radionuclide concentrations, dose rates, or doses expected to result from various countermeasures or remediation efforts. Specific objectives of the Working Group have included (1) the identification of realistic scenarios for a wide variety of situations, (2) comparison and testing of approaches and models for assessing the significance of a given contamination event and for guiding decisions about countermeasures or remediation measures implemented to reduce doses to humans or to clean up the contaminated area, and (3) improving the understanding of processes and situations that affect the spread of contamination to aid in the development of appropriate models and parameter values for use in assessment of these situations. The major activities of the Working Group have included three areas. The first of these was a review of the available modelling approaches and computer models for use in assessing urban contamination and potential countermeasures or remediation activities. The second area of work was a modelling exercise based on data

FOREST AREA DERIVATION FROM SENTINEL-1 DATA

Directory of Open Access Journals (Sweden)

A. Dostálová

2016-06-01

Full Text Available The recently launched Sentinel-1A provides the high resolution Synthetic Aperture Radar (SAR data with very high temporal coverage over large parts of European continent. Short revisit time and dual polarization availability supports its usability for forestry applications. The following study presents an analysis of the potential of the multi-temporal dual-polarization Sentinel-1A data for the forest area derivation using the standard methods based on Otsu thresholding and K-means clustering. Sentinel-1 data collected in winter season 2014-2015 over a test area in eastern Austria were used to derive forest area mask with spatial resolution of 10m and minimum mapping unit of 500 m2. The validation with reference forest mask derived from airborne full-waveform laser scanning data revealed overall accuracy of 92 % and kappa statistics of 0.81. Even better results can be achieved when using external mask for urban areas, which might be misclassified as forests when using the introduced approach based on SAR data only. The Sentinel-1 data and the described methods are well suited for forest change detection between consecutive years.

Young Investigator Proposal, Research Area 7.4 Reactive Chemical Systems: Multifunctional, Bimetallic Nanomaterials Prepared by Atomic Layer Electroless Deposition

Science.gov (United States)

2017-09-30

Report: Young Investigator Proposal, Research Area 7.4 Reactive Chemical Systems: Multifunctional, Bimetallic Nanomaterials Prepared by Atomic Layer ...Chemical Systems: Multifunctional, Bimetallic Nanomaterials Prepared by Atomic Layer Electroless Deposition Report Term: 0-Other Email: pcappillino... Layer Electroless Deposition (ALED, Figure 1) is the ability to tune growth mechanism, hence growth morphology, by altering conditions. In this

Remedial investigation report on Waste Area Group 5 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 1: Technical summary

International Nuclear Information System (INIS)

1995-03-01

A remedial investigation (RI) was performed to support environmental restoration activities for Waste Area Grouping (WAG) 5 at the Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee. The WAG 5 RI made use of the observational approach, which concentrates on collecting only information needed to assess site risks and support future cleanup work. This information was interpreted and is presented using the framework of the site conceptual model, which relates contaminant sources and release mechanisms to migration pathways and exposure points that are keyed to current and future environmental risks for both human and ecological receptors. The site conceptual model forms the basis of the WAG 5 remedial action strategy and remedial action objectives. The RI provided the data necessary to verify this model and allows recommendations to be made to accomplish those objectives

Remedial investigation report on Waste Area Grouping 5 at Oak Ridge National Laboratory, Oak Ridge, Tennessee. Volume 1: Technical summary

International Nuclear Information System (INIS)

1995-09-01

A remedial investigation (RI) was performed to support environmental restoration activities for Waste Area Grouping (WAG) 5 at the Oak Ridge National Laboratory (ORNL) in Oak Ridge, Tennessee. The WAG 5 RI made use of the observational approach, which concentrates on collecting only information needed to assess site risks and support future cleanup work. This information was interpreted and is presented using the framework of the site conceptual model, which relates contaminant sources and release mechanisms to migration pathways and exposure points that are keyed to current and future environmental risks for both human and ecological receptors. The site conceptual model forms the basis of the WAG 5 remedial action strategy and remedial action objectives. The RI provided the data necessary to verify this model and allows recommendations to be made to accomplish those objectives.

7 CFR 1.22 - Authentication.

Science.gov (United States)

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Authentication. 1.22 Section 1.22 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Official Records § 1.22 Authentication. When a request is received for an authenticated copy of a document that the agency determines to make...

7 CFR 1410.1 - Administration.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1410.1 Section 1410.1 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CONSERVATION RESERVE PROGRAM § 1410.1 Administration. (a...

ABO blood groups of residents and the ABO host choice of malaria vectors in southern Iran.

Science.gov (United States)

Anjomruz, Mehdi; Oshaghi, Mohammad A; Sedaghat, Mohammad M; Pourfatollah, Ali A; Raeisi, Ahmad; Vatandoost, Hassan; Mohtarami, Fatemeh; Yeryan, Mohammad; Bakhshi, Hassan; Nikpoor, Fatemeh

2014-01-01

Recent epidemiological evidences revealed the higher prevalence of 'O' blood group in the residents of malaria-endemic areas. Also some data indicated preference of mosquitoes to 'O' group. The aim of this study was to determine ABO group ratio in the residents as well as ABO group preference of Anopheles in two malaria endemic areas in south of Iran. Agglutination method was used for ABO typing of residents. Field blood fed Anopheles specimens were tested against vertebrate DNA using mtDNA-cytB PCR-RFLP and then the human fed specimens were tested for ABO groups using multiplex allele-specific PCR. A total of 409 human blood samples were identified, of which 150(36.7%) were 'O' group followed by 113(27.6%), 109(26.7%), and 37(9.0%) of A, B, and AB groups respectively. Analyzing of 95 blood fed mosquitoes revealed that only four Anopheles stephensi had fed human blood with A(1), B(1), and AB(2) groups. Result of this study revealed high prevalence of O group in south of Iran. To our knowledge, it is the first ABO molecular typing of blood meal in mosquitoes; however, due to low number of human blood fed specimens, ABO host choice of the mosquitoes remains unknown. This study revealed that ABO blood preference of malaria vectors and other arthropod vectors deserves future research. Copyright © 2013 Elsevier Inc. All rights reserved.

No difference in long-term trunk muscle strength, cross-sectional area, and density in patients with chronic low back pain 7 to 11 years after lumbar fusion versus cognitive intervention and exercises.

Science.gov (United States)

Froholdt, Anne; Holm, Inger; Keller, Anne; Gunderson, Ragnhild B; Reikeraas, Olav; Brox, Jens I

2011-08-01

Reduced muscle strength and density observed at 1 year after lumbar fusion may deteriorate more in the long term. To compare the long-term effect of lumbar fusion and cognitive intervention and exercises on muscle strength, cross-sectional area, density, and self-rated function in patients with chronic low back pain (CLBP) and disc degeneration. Randomized controlled study with a follow-up examination at 8.5 years (range, 7-11 years). Patients with CLBP and disc degeneration randomized to either instrumented posterolateral fusion of one or both of the two lower lumbar levels or a 3-week cognitive intervention and exercise program were included. Isokinetic muscle strength was measured by a Cybex 6000 (Cybex-Lumex, Inc., Ronkonkoma, NY, USA). All patients had previous experience with the test procedure. The back extension (E) flexion (F) muscles were tested, and the E/F ratios were calculated. Cross-sectional area and density of the back muscles were measured at the L3-L4 segment by computed tomography. Patients rated their function by the General Function Score. Trunk muscle strength, cross-sectional area, density, and self-rated function. Fifty-five patients (90%) were included at long-term follow-up. There were no significant differences in cross-sectional area, density, muscle strength, or self-rated function between the two groups. The cognitive intervention and exercise group increased trunk muscle extension significantly (parea was reduced by 8.5%, and muscle density was reduced by 27%. Although this study did not assess the morphology of muscles likely damaged by surgery, trunk muscle strength and cross-sectional area above the surgical levels are not different between those who had lumbar fusion or cognitive intervention and exercises at 7- to 11-year follow-up. Copyright © 2011 Elsevier Inc. All rights reserved.

1 CFR 11.7 - Federal Register Index.

Science.gov (United States)

2010-01-01

... 1 General Provisions 1 2010-01-01 2010-01-01 false Federal Register Index. 11.7 Section 11.7... REGISTER PUBLICATIONS SUBSCRIPTIONS § 11.7 Federal Register Index. The annual subscription price for the monthly Federal Register Index, purchased separately, in paper form, is $29. The price excludes postage...

7 CFR 1724.1 - Introduction.

Science.gov (United States)

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Introduction. 1724.1 Section 1724.1 Agriculture... ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES General § 1724.1 Introduction. (a) The policies, procedures and requirements in this part implement certain provisions of the...

Tuberculosis among older adults in Zambia: burden and characteristics among a neglected group.

Science.gov (United States)

Coffman, Jenna; Chanda-Kapata, Pascalina; Marais, Ben J; Kapata, Nathan; Zumla, Alimuddin; Negin, Joel

2017-10-12

The 2010 Global Burden of Disease estimates show that 57% of all TB deaths globally occurred among adults older than 50 years of age. Few studies document the TB burden among older adults in Southern Africa. We focused on adults older than 55 years to assess the relative TB burden and associated demographic factors. A cross sectional nationally representative TB prevalence survey conducted of Zambian residents aged 15 years and above from 66 clusters across all the 10 provinces of Zambia. Evaluation included testing for TB as well as an in-depth questionnaire. We compared survey data for those aged 55 and older to those aged 15-54 years. Survey results were also compared with 2013 routinely collected programmatic notification data to generate future hypotheses regarding active and passive case finding. Among older adults with TB, 30/ 54 (55.6%) were male, 3/27 (11.1%) were HIV infected and 35/54 (64.8%) lived in rural areas. TB prevalence was higher in those aged ≥55 (0.7%) than in the 15-54 age group (0.5%). Males had higher rates of TB across both age groups with 0.7% (15-54) and 1.0% (≥55) compared with females 0.4% (15-54) and 0.6% (≥55). In rural areas, the prevalence of TB was significantly higher among older than younger adults (0.7% vs 0.3%), while the HIV infection rate was among TB patients was lower (11.1% vs 30.8%). The prevalence survey detected TB in 54/7484 (0.7%) of older adults compared to 3619/723,000 (0.5%) reported in 2013 programmatic data. High TB rates among older adults in TB endemic areas justify consideration of active TB case finding and prevention strategies.

Prospective randomized phase II study of FOLFIRI versus FOLFOX7 in advanced gastric adenocarcinoma: a Chinese Western Cooperative Gastrointestinal Oncology Group Study.

Science.gov (United States)

Li, Qiu; Wen, Feng; Zhou, Chengya; Qiu, Meng; Liu, Jiyan; Chen, Jing; Yi, Cheng; Li, Zhiping; Luo, Deyun; Xu, Feng; Cai, Xiaohong; Bi, Feng

2017-11-17

Until now, no standard chemotherapy has been widely accepted for advanced gastric cancer (GC). The current research aimed to compare folinic acid, fluorouracil with irinotecan (mFOLFIRI) or with oxaliplatin (mFOLFOX7) as first-line treatments in patients with locally advanced GC in an open, randomized, phase II study. Previously untreated metastatic or recurrent GC patients with measurable disease received mFOLFIRI (arm A) or mFOLFOX7 (arm B) every 2 weeks. The defined second-line treatment was mFOLFOX7 for arm A and mFOLFIRI for arm B. Primary endpoint was progression-free survival (PFS), and secondary endpoints were overall survival (OS), disease control rate (DCR) and toxicity. The evaluable population consisted of 128 patients (54 in arm A; 74 in arm B). Median PFS of arm A was 2.9 months (m) (95% confidence interval, CI , 1.9 to 4.1 m) versus 4.1 m (95% CI , 3.2 to 4.8 m) for arm B ( p = 0.109). Median OS was 9.9 months (95% CI , 6.0 to 13.5 m) for arm A versus 12.0 m for arm B (95% CI , 10.3 to 13.7m; p = 0.431). DCRs for arm A and arm B were 59.3% and 66.3%, respectively ( p = 0.850). In subgroup analysis of the patients who completed both treatment lines per protocol, the median first-line PFS was 2.1 m for the mFOLFIRI/mFOLFOX7arm versus 8.0 m for the mFOLFOX7/mFOLFIRI arm ( p = 0.053), and the median second-line PFS values were 1.2 m versus 5.1 m ( p = 0.287). Total PFS and OS were 8.1m and 11.0 m for the mFOLFIRI/mFOLFOX7 group compared with 12.2m and 20.2 m for the mFOLFOX7/mFOLFIRI group ( p = 0.008, p = 0.030). Both regimens were well-tolerated with acceptable and manageable toxicities. Hence, there was no significant difference in the PFS or DCR. However, mFOLFOX7 followed by mFOLFIRI might have a better OS.

Simulated structure and imaging of NTCDI on Si(1 1 1)-7 × 7 : a combined STM, NC-AFM and DFT study

Science.gov (United States)

Jarvis, S. P.; Sweetman, A. M.; Lekkas, I.; Champness, N. R.; Kantorovich, L.; Moriarty, P.

2015-02-01

The adsorption of naphthalene tetracarboxylic diimide (NTCDI) on Si(1 1 1)-7 × 7 is investigated through a combination of scanning tunnelling microscopy (STM), noncontact atomic force microscopy (NC-AFM) and density functional theory (DFT) calculations. We show that NTCDI adopts multiple planar adsorption geometries on the Si(1 1 1)-7 × 7 surface which can be imaged with intramolecular bond resolution using NC-AFM. DFT calculations reveal adsorption is dominated by covalent bond formation between the molecular oxygen atoms and the surface silicon adatoms. The chemisorption of the molecule is found to induce subtle distortions to the molecular structure, which are observed in NC-AFM images.

7 CFR 3402.4 - Food and agricultural sciences areas targeted for National Needs Graduate and Postdoctoral...

Science.gov (United States)

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Food and agricultural sciences areas targeted for..., AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS... sciences areas targeted for National Needs Graduate and Postdoctoral Fellowship Grants Program support...

SCARB1 rs5888 is associated with the risk of age-related macular degeneration susceptibility and an impaired macular area.

Science.gov (United States)

Stanislovaitiene, Daiva; Zaliuniene, Dalia; Krisciukaitis, Algimantas; Petrolis, Robertas; Smalinskiene, Alina; Lesauskaite, Vita; Tamosiunas, Abdonas; Lesauskaite, Vaiva

2017-01-01

Age-related macular degeneration (ARMD), a progressive retinal disease, is responsible for an impaired central vision in about 180 million people worldwide. Current options for ARMD prevention and treatment are limited due to an incomplete understanding of disease etiopathogenesis. We aimed to test the hypothesis that the single nucleotide polymorphism rs5888 of SCARB1 gene reflecting lipid and antioxidant micronutrient metabolism pathways is associated with ARMD susceptibility and to evaluate if there is any relation between SCARB1 rs5888 and the macular lesion area. The prospective case-control study included patients with ARMD (n = 215) and the reference group (n = 238) drawn from a random sample of the Lithuanian population (n = 1436). The genotyping test of SCARB1 rs5888 was carried out using the real-time polymerase chain reaction method. Regression analysis adjusted by gender and age demonstrated that SCARB1 rs5888 TT genotype significantly decreased the odds for ARMD development (OR: 0.61, 95%; CI: 0.380-0.981, p = 0.04). A smoking habit and leading an outdoor life are associated with larger macular lesion areas in ARMD patients (0.54 (0.00-39.06) vs. 3.09 (0.02-19.30) and 0.27 (0.00-34.57) vs. 0.75 (0.00-39.06), respectively). In late stage ARMD subjects with CT genotype, the macular lesion area was larger than in TT carriers (7.64 (0.49-39.06) mm 2 vs. 5.02 (0.03-37.06) mm 2 , p = 0.006). SCARB1 rs5888 and environmental oxidative stress have a prominent role in ARMD susceptibility, early ARMD progression to advanced stage disease and even in the outcome of the disease-an area of macular lesion.

A study of prevalence of sexually transmitted infections & response to syndromic treatment among married women of reproductive age group in rural area of Parol Primary Health Centre under Thane district, Mahrashtra , India

Directory of Open Access Journals (Sweden)

Parmar Mehul Tribhovandas

2013-07-01

Full Text Available Objectives To study prevalence of Sexually Transmitted Infections (STIs - symptomatic, clinical & laboratorial & response to syndromic treatment in among STI groups. Design Community based interventional study Setting Rual area-Parol Primary Health Centre(PHC, District Thane, Maharashtra state. Poulation Women of reproductive age groups 15 -45 years Methods Community based interventional study, conducted among representative group of 415 women of reproductive age groups, by simple random sampling technique in Parol PHC, District Thane, Maharashtra state. All symptomatic & asymptomatic women were counseled for examination & investigations & given syndromic treatment. Follow-up done to assess impact of syndromic treatment. Main Outcome Prevalence of STI symptomatically was 39%, clinically 32.3% & Laboratorial 26%. After syndromic treatment, prevalence of STIs has statistically significantly reduced. Statistical Analysis Z-test Results Of the surveyed women (415, prevalence of STI symptomatically was 39%, clinically 32.3% & Laboratorial 26%. The most common presenting symptom was vaginal discharge (36.4% followed by Burning Micturition (24.7%, Vulval itching (17.3%, Lower abdominal pain (13% & Genital ulcer (8.6%. Clinically, 55.2% women were diagnosed as cervicitis & 44.8% as PID. Laboratorial diagnosed STIs were - vaginal candidiasis 46.3%, Bacterial vaginosis 25%, Trichmoniasis 19.4 %, Genital Herpes 7.4% & HIV 1.9%. After syndromic treatment, prevalence of STIs has statistically significantly reduced. Conclusion: Syndromic Rx & health education can definitely reduce STIs.

2-(5,7-Dimethyl-3-methylsulfanyl-1-benzofuran-2-ylacetic acid

Directory of Open Access Journals (Sweden)

Hong Dae Choi

2008-08-01

Full Text Available The title compound, C13H14O3S, was prepared by alkaline hydrolysis of ethyl 2-(5,7-dimethyl-3-methylsulfanyl-1-benzofuran-2-ylacetate. In the crystal structure, the carboxyl groups are involved in intermolecular O—H...O hydrogen bonds, which link the molecules into centrosymmetric dimers. These dimers are further packed into stacks along the a axis by weak C—H...π interactions.

OBSERVATIONS OF THE YOUNG SUPERNOVA REMNANT RX J1713.7-3946 WITH THE FERMI LARGE AREA TELESCOPE

International Nuclear Information System (INIS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Borgland, A. W.; Baldini, L.; Bellazzini, R.; Bregeon, J.; Ballet, J.; Barbiellini, G.; Baring, M. G.; Bastieri, D.; Bonamente, E.; Bouvier, A.; Brandt, T. J.; Brigida, M.; Bruel, P.

2011-01-01

We present observations of the young supernova remnant (SNR) RX J1713.7-3946 with the Fermi Large Area Telescope (LAT). We clearly detect a source positionally coincident with the SNR. The source is extended with a best-fit extension of 0. 0 55 ± 0. 0 04 matching the size of the non-thermal X-ray and TeV gamma-ray emission from the remnant. The positional coincidence and the matching extended emission allow us to identify the LAT source with SNR RX J1713.7-3946. The spectrum of the source can be described by a very hard power law with a photon index of Γ = 1.5 ± 0.1 that coincides in normalization with the steeper H.E.S.S.-detected gamma-ray spectrum at higher energies. The broadband gamma-ray emission is consistent with a leptonic origin as the dominant mechanism for the gamma-ray emission.

7 CFR 331.1 - Definitions.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Definitions. 331.1 Section 331.1 Agriculture..., DEPARTMENT OF AGRICULTURE POSSESSION, USE, AND TRANSFER OF SELECT AGENTS AND TOXINS § 331.1 Definitions... the environment, or isolates or cultures from such samples, for diagnosis, verification, or...

7 CFR 1900.1 - General.

Science.gov (United States)

2010-01-01

... 7 Agriculture 12 2010-01-01 2010-01-01 false General. 1900.1 Section 1900.1 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS-COOPERATIVE... GENERAL Delegations of Authority § 1900.1 General. The authorities contained in this subpart apply to all...

Cyclosporine nephrotoxicity in type 1 diabetic patients. A 7-year follow-up study

DEFF Research Database (Denmark)

Parving, H H; Tarnow, L; Nielsen, F S

1999-01-01

OBJECTIVE: To evaluate kidney function 7 years after the end of treatment with cyclosporine A (CsA) (initial dosage of 9.3 tapered off to 7.0 mg.kg-1.day-1) in young patients (mean age 20 years) with newly diagnosed type 1 diabetes participating in a randomized, double-blind, placebo-controlled Cs...... of study medication, two CsA group patients and one control patient were lost to follow-up. One placebo-treated patient developed IgA nephropathy (biopsy proven) and was excluded. Four CsA-treated patients developed persistently elevated UAER > 30 mg/24 h (n = 3 with microalbuminuria), whereas all the 17...... randomly selected CsA-treated patients had a kidney biopsy performed shortly after the CsA treatment was stopped. Interstitial fibrosis/tubular atrophy and/or arteriolopathy were present in two subjects who both subsequently developed persistent microalbuminuria. CONCLUSIONS: The results of our 7-year...

Chemical Safety Vulnerability Working Group report. Volume 1

Energy Technology Data Exchange (ETDEWEB)

1994-09-01

The Chemical Safety Vulnerability (CSV) Working Group was established to identify adverse conditions involving hazardous chemicals at DOE facilities that might result in fires or explosions, release of hazardous chemicals to the environment, or exposure of workers or the public to chemicals. A CSV Review was conducted in 148 facilities at 29 sites. Eight generic vulnerabilities were documented related to: abandoned chemicals and chemical residuals; past chemical spills and ground releases; characterization of legacy chemicals and wastes; disposition of legacy chemicals; storage facilities and conditions; condition of facilities and support systems; unanalyzed and unaddressed hazards; and inventory control and tracking. Weaknesses in five programmatic areas were also identified related to: management commitment and planning; chemical safety management programs; aging facilities that continue to operate; nonoperating facilities awaiting deactivation; and resource allocations. Volume 1 contains the Executive summary; Introduction; Summary of vulnerabilities; Management systems weaknesses; Commendable practices; Summary of management response plan; Conclusions; and a Glossary of chemical terms.

Chemical Safety Vulnerability Working Group report. Volume 1

International Nuclear Information System (INIS)

1994-09-01

The Chemical Safety Vulnerability (CSV) Working Group was established to identify adverse conditions involving hazardous chemicals at DOE facilities that might result in fires or explosions, release of hazardous chemicals to the environment, or exposure of workers or the public to chemicals. A CSV Review was conducted in 148 facilities at 29 sites. Eight generic vulnerabilities were documented related to: abandoned chemicals and chemical residuals; past chemical spills and ground releases; characterization of legacy chemicals and wastes; disposition of legacy chemicals; storage facilities and conditions; condition of facilities and support systems; unanalyzed and unaddressed hazards; and inventory control and tracking. Weaknesses in five programmatic areas were also identified related to: management commitment and planning; chemical safety management programs; aging facilities that continue to operate; nonoperating facilities awaiting deactivation; and resource allocations. Volume 1 contains the Executive summary; Introduction; Summary of vulnerabilities; Management systems weaknesses; Commendable practices; Summary of management response plan; Conclusions; and a Glossary of chemical terms

Preliminary site description Forsmark area - version 1.1

International Nuclear Information System (INIS)

2004-03-01

This report presents the interim version (model version 1.1) of the preliminary Site Descriptive Model for Forsmark. The basis for this interim version is quality-assured, geoscientific and ecological field data from Forsmark that were available in the SKB databases SICADA and GIS at April 30, 2003 as well as version 0 of the Site Descriptive Model. The new data acquired during the initial site investigation phase to the date of data freeze 1.1 constitute the basis for the updating of version 0 to version 1.1. These data originate from surface investigations on the candidate area with its regional environment and from drilling and investigations in boreholes. The surface-based data sets were rather extensive whereas the data sets from boreholes were limited to information from one 1,000 m deep cored borehole (KFM01A) and eight 150 to 200 m deep percussion-drilled boreholes in the Forsmark candidate area. Discipline specific models are developed for a selected regional and local model volume and these are then integrated into a site description. The current methodologies for developing the discipline specific models and the integration of these are documented in methodology reports or strategy reports. In the present work, the guidelines given in those reports were followed to the extent possible with the data and information available at the time for data freeze for model version 1.1. Compared with version 0 there are considerable additional features in the version 1.1, especially in the geological description and in the description of the near surface. The geological models of lithology and deformation zones are based on borehole information and much higher resolution surface data. The existence of highly fractured sub-horizontal zones has been verified and these are now part of the model of the deformation zones. A discrete fracture network (DFN) model has also been developed. The rock mechanics model is based on strength information from SFR and an empirical

Holomorphic D7-branes and flavored N=1 gauge theories

International Nuclear Information System (INIS)

Ouyang, Peter

2004-01-01

We consider D7-branes in the gauge theory/string theory correspondence, using a probe approximation. The D7-branes have four directions embedded holomorphically in a non-compact Calabi-Yau 3-fold (which for specificity we take to be the conifold) and their remaining four directions are parallel to a stack of D3-branes transverse to the Calabi-Yau space. The dual gauge theory, which has N=1 supersymmetry, contains quarks which transform in the fundamental representation of the gauge group, and we identify the interactions of these quarks in terms of a superpotential. By activating three-form fluxes in the gravity background, we obtain a dual gauge theory with a cascade of Seiberg dualities. We find a supersymmetric supergravity solution for the leading backreaction effects of the D7-branes, valid for large radius. The cascading theory with flavors exhibits the interesting phenomenon that the rate of the cascade slows and can stop as the theory flows to the infrared

1 CFR 5.7 - Delivery and mailing.