Sample records for applied epidemiology program

  1. Applied epidemiology: another tool in dairy herd health programs? (United States)

    Frankena, K; Noordhuizen, J P; Stassen, E N


    Data bases of herd health programs concern data from individual animals mainly. Several parameters that determine herd performance can be calculated from these programs, and by comparing actual values with standard values, areas for further improvement of health (and production) can be advised. However, such advice is usually not backed up by the proper statistical analyses. Moreover, data concerning the environment of the animals are not present and hence advice concerning multifactorial diseases are based on common knowledge and experience. Veterinary epidemiology offers methods that might improve the value of herd health programs by identification and quantification of factors and conditions contributing to multifactorial disease occurrence. Implementation of these methods within herd health programs will lead to more scientifically sound advice.

  2. Epidemiology & Genomics Research Program (United States)

    The Epidemiology and Genomics Research Program, in the National Cancer Institute's Division of Cancer Control and Population Sciences, funds research in human populations to understand the determinants of cancer occurrence and outcomes.

  3. Applying molecular epidemiology in pediatric leukemia. (United States)

    Schiffman, Joshua D


    Molecular epidemiology is the study of genetic and environmental risk for disease, with much effort centered on cancer. Childhood leukemia occurs in nearly a third of all patients newly diagnosed with pediatric cancer. only a small percentage of these new cases of childhood leukemia are associated with high penetrant hereditary cancer syndromes. Childhood leukemia, especially acute lymphoblastic leukemia, has been associated with a dysregulated immune system due to delayed infectious exposure at a young age. Identical twins with childhood leukemia suggest that acute lymphoblastic leukemia begins in utero and that the concordant presentation is due to a shared preleukemia subclone via placental transfer. Investigation of single nucleotide polymorphisms within candidate genes find that leukemia risk may be attributed to population-based polymorphisms affecting folate metabolism, xenobiotic metabolism, DNA repair, immunity, and B-cell development. More recently, genome-wide association studies for leukemia risk has led investigators to genes associated with B-cell development. When describing leukemia predisposition due to hereditary cancer syndromes, the following 6 categories become apparent on the basis of biology and clinical presentation: (1) genetic instability/DNA repair syndromes, (2) cell cycle/differentiation syndromes, (3) bone marrow failure syndromes, (4) telomere maintenance syndromes, (5) immunodeficiency syndromes, and (6) transcription factor syndromes and pure familial leukemia. understanding the molecular epidemiology of childhood leukemia can affect the treatment and tumor surveillance strategies for these high risk patients and their family members.

  4. In snow's footsteps: Commentary on shoe-leather and applied epidemiology. (United States)

    Koo, Denise; Thacker, Stephen B


    The term shoe-leather epidemiology is often synonymous with field epidemiology or intervention epidemiology. All 3 terms imply investigations initiated in response to urgent public health problems and for which the investigative team does much of its work in the field (i.e., outside the office or laboratory). Alexander D. Langmuir is credited with articulating the concept of disease surveillance as it is applied to populations rather than individuals. He also founded the Epidemic Intelligence Service (EIS) Program in 1951, a 2-year training experience in applied epidemiology that places professionals in the field, domestically and internationally, in real-life situations. Today, 70-90 EIS officers are assigned each year to Centers for Disease Control and Prevention programs and to state and local health departments to meet the broad spectrum of challenges in chronic disease, injury prevention, violence, environmental health, occupational safety and health, and maternal and child health, as well as infectious diseases. Throughout their assignments, EIS officers are encouraged to strive for analytic rigor as well as public health consequence, which requires technical competence blended with good judgment and awareness of context. Effective applied epidemiologists must have skills beyond just epidemiology to improve a population's health; the field of applied epidemiology requires multiple team members, all having different but complementary skills, to be effective.

  5. DOE (Department of Energy) Epidemiologic Research Program

    Energy Technology Data Exchange (ETDEWEB)


    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and of the operation of DOE facilities. The program is divided into seven general areas of activity; the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 340 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliography is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by laboratory and by year and also summarizes the results from individual authors by journal.

  6. Implementing a Graduate Certificate Program in Cardiovascular Epidemiology: The Jackson Heart Study

    Directory of Open Access Journals (Sweden)

    Brenda W. Campbell Jenkins


    Full Text Available The Jackson Heart Study (JHS is committed to providing opportunities for expanding the understanding of the epidemiology, diagnosis, prevention, and treatment of cardiovascular diseases. The JHS Graduate Training and Education Center (GTEC has initiated the Daniel Hale Williams Scholar (DHWS program where students are afforded the opportunity to interact with epidemiologists and other biomedical scientists to learn to identify, predict, and prevent cardiovascular disease using the Jackson Heart Study data. This study describes the structured programs developed by JHS GTEC seeking to alleviate the shortage of trained professionals in cardiovascular epidemiology by training graduate students while they complete their academic degrees. The DHWS program provides: (1 an enrichment curriculum; (2 a learning community; (3 quarterly seminars; and (4 a Summer Institute. Students attend enrichment activities comprising: (1 Applied Biostatistics; (2 Cardiovascular Disease Epidemiology; (3 Social Epidemiology; (4 Emerging Topics; and (5 Research Writing. Training focuses on developing proficiency in cardiovascular health knowledge. The DHWS program is a unique strategy for incorporating rigorous academic and career-focused training to graduate students and has enabled the acquisition of competencies needed to impact cardiovascular disease management programs.

  7. Implementing a Graduate Certificate Program in Cardiovascular Epidemiology: The Jackson Heart Study. (United States)

    Campbell Jenkins, Brenda W; Addison, Clifton; Wilson, Gregory; Young, Lavon; Fields, Regina; Woodberry, Clevette; Payton, Marinelle


    The Jackson Heart Study (JHS) is committed to providing opportunities for expanding the understanding of the epidemiology, diagnosis, prevention, and treatment of cardiovascular diseases. The JHS Graduate Training and Education Center (GTEC) has initiated the Daniel Hale Williams Scholar (DHWS) program where students are afforded the opportunity to interact with epidemiologists and other biomedical scientists to learn to identify, predict, and prevent cardiovascular disease using the Jackson Heart Study data. This study describes the structured programs developed by JHS GTEC seeking to alleviate the shortage of trained professionals in cardiovascular epidemiology by training graduate students while they complete their academic degrees. The DHWS program provides: (1) an enrichment curriculum; (2) a learning community; (3) quarterly seminars; and (4) a Summer Institute. Students attend enrichment activities comprising: (1) Applied Biostatistics; (2) Cardiovascular Disease Epidemiology; (3) Social Epidemiology; (4) Emerging Topics; and (5) Research Writing. Training focuses on developing proficiency in cardiovascular health knowledge. The DHWS program is a unique strategy for incorporating rigorous academic and career-focused training to graduate students and has enabled the acquisition of competencies needed to impact cardiovascular disease management programs.

  8. Applied Integer Programming Modeling and Solution

    CERN Document Server

    Chen, Der-San; Dang, Yu


    An accessible treatment of the modeling and solution of integer programming problems, featuring modern applications and software In order to fully comprehend the algorithms associated with integer programming, it is important to understand not only how algorithms work, but also why they work. Applied Integer Programming features a unique emphasis on this point, focusing on problem modeling and solution using commercial software. Taking an application-oriented approach, this book addresses the art and science of mathematical modeling related to the mixed integer programming (MIP) framework and

  9. Active epidemiological surveillance in the program of poliomyelitis eradication in Serbia

    Directory of Open Access Journals (Sweden)

    Jevremović Ivana


    Full Text Available The main strategy of the worldwide Program of Poliomyelitis Eradication is based on immunization with oral poliovirus vaccine and active epidemiological surveillance aimed to demonstrate the absence of wild poliovirus circulation. The specification of the surveillance in the program, reporting and investigation of certain syndrome – the acute flaccid paralysis - as a specific feature of surveillance of poliomyelitis, is a new experience both for clinicians and epidemiologists. Along with the achieved results, problems in conducting the active epidemiological surveillance in Serbia, applied measures, and suggestions for improving its quality were presented. This experience might help in implementing the active surveillance for some other diseases that could be prevented by vaccine immunization.

  10. [Measles: the disease, epidemiology, history and vaccination programs in Chile]. (United States)

    Delpiano, Luis; Astroza, Leonor; Toro, Jorge


    Measles, one of most important inmuno-preventable diseases, remains as a worldwide concern issue with an important morbidity and mortality. Particularly in the America region declared free of measles in 2010 by WHO, they still appear imported cases that origin outbreaks of variable magnitude in susceptible subjects usually none vaccinated which is the current situation in Santiago, the capital city of Chile. In this review we present characteristics of the etiological agent, the disease, epidemiological aspects with national historical focus, impact of immunization programs and outbreaks in Chile, in order to contribute to knowledge and management of this always present public health problem.

  11. DOE (Department of Energy) Epidemiologic Research Program: Selected bibliography

    Energy Technology Data Exchange (ETDEWEB)


    The objective of the Department of Energy (DOE) Epidemiologic Research Program is to determine the human health effects resulting from the generation and use of energy, and from the operation of DOE facilities. The program has been divided into seven general areas of activity: the Radiation Effects Research Foundation (RERF) which supports studies of survivors of the atomic weapons in Hiroshima and Nagasaki, mortality and morbidity studies of DOE workers, studies on internally deposited alpha emitters, medical/histologic studies, studies on the genetic aspects of radiation damage, community health surveillance studies, and the development of computational techniques and of databases to make the results as widely useful as possible. Excluding the extensive literature from the RERF, the program has produced 380 publications in scientific journals, contributing significantly to improving the understanding of the health effects of ionizing radiation exposure. In addition, a large number of public presentations were made and are documented elsewhere in published proceedings or in books. The purpose of this bibliograhpy is to present a guide to the research results obtained by scientists supported by the program. The bibliography, which includes doctoral theses, is classified by national laboratory and by year. Multi-authored studies are indicated only once, according to the main supporting laboratory.

  12. NASA's Applied Sciences: Natural Disasters Program (United States)

    Kessler, Jason L.


    Fully utilize current and near-term airborne and spaceborne assets and capabilities. NASA spaceborne instruments are for research but can be applied to natural disaster response as appropriate. NASA airborne instruments can be targeted specifically for disaster response. Could impact research programs. Better flow of information improves disaster response. Catalog capability, product, applicable disaster, points of contact. Ownership needs to come from the highest level of NASA - unpredictable and irregular nature of disasters requires contingency funding for disaster response. Build-in transfer of applicable natural disaster research capabilities to operational functionality at other agencies (e.g., USFS, NOAA, FEMA...) at the outset, whenever possible. For the Decadal Survey Missions, opportunities exist to identify needs and requirements early in the mission design process. Need to understand additional needs and commitments for meeting the needs of the disaster community. Opportunity to maximize disaster response and mitigation from the Decadal Survey Missions. Additional needs or capabilities may require agency contributions.

  13. Diabetic Retinopathy in Italy: Epidemiology Data and Telemedicine Screening Programs

    Directory of Open Access Journals (Sweden)

    Stela Vujosevic


    Full Text Available In Italy, the number of people living with diabetes is about 3.5 million (5.5% of the population, with an increase by about 60% in the last 20 years and with 1 person out of 3 older than 65 years. The Italian Health Service system estimates that 10 billion euros is spent annually on caring for patients with diabetes, a figure that increases yearly. No national data on prevalence and incidence of legal blindness in patients with diabetes and no national registry of patients with diabetic retinopathy (DR are currently available. However, the available epidemiological data (in several locations throughout the country are consistent with those reported in other European countries. The use of telemedicine for the screening of DR in Italy is confined to geographically limited locations. The available data in the literature on implementation and use of telematic screening proved to be successful from patient, caregiver, and authorities point of view. This review addresses the available epidemiological data on DR and telematic screening realities in Italy and thus may help in establishing a national screening program.

  14. Diabetic Retinopathy in Italy: Epidemiology Data and Telemedicine Screening Programs (United States)

    Midena, Edoardo


    In Italy, the number of people living with diabetes is about 3.5 million (5.5% of the population), with an increase by about 60% in the last 20 years and with 1 person out of 3 older than 65 years. The Italian Health Service system estimates that 10 billion euros is spent annually on caring for patients with diabetes, a figure that increases yearly. No national data on prevalence and incidence of legal blindness in patients with diabetes and no national registry of patients with diabetic retinopathy (DR) are currently available. However, the available epidemiological data (in several locations throughout the country) are consistent with those reported in other European countries. The use of telemedicine for the screening of DR in Italy is confined to geographically limited locations. The available data in the literature on implementation and use of telematic screening proved to be successful from patient, caregiver, and authorities point of view. This review addresses the available epidemiological data on DR and telematic screening realities in Italy and thus may help in establishing a national screening program. PMID:27990441

  15. Unique Characteristics of a Graduate Program in Applied Communication. (United States)

    Schrader, Stuart M.; Mills, Kim White; Dick, Robert


    Addresses one Communication Department's sojourn in designing, developing, and proposing a unique Master of Arts in Applied Communication. Discusses steps in developing an applied graduate program, the mission statement for the program, the curriculum, the expected impact of the graduate program on the undergraduate program, and program strengths.…

  16. Fusion programs in applied plasma physics

    Energy Technology Data Exchange (ETDEWEB)


    The objectives of the theoretical science program are: To support the interpretation of present experiments and predict the outcome of future planned experiments; to improve on existing models and codes and validate against experimental results; and to conduct theoretical physics development of advanced concepts with applications for DIII-D and future devices. Major accomplishments in FY91 include the corroboration between theory and experiment on MHD behavior in the second stable regime of operation on DIII-D, and the frequency and mode structure of toroidal Alfven eigenmodes in high beta, shaped plasmas. We have made significant advances in the development of the gyro-Landau fluid approach to turbulence simulation which more accurately models kinetic drive and damping mechanisms. Several theoretical models to explain the bifurcation phenomenon in L- to H-mode transition were proposed providing the theoretical basis for future experimental verification. The capabilities of new rf codes have been upgraded in response to the expanding needs of the rf experiments. Codes are being employed to plan for a fully non-inductive current drive experiment in a high beta, enhanced confinement regime. GA's experimental effort in Applied Physics encompasses two advanced diagnostics essential for the operation of future fusion experiments: Alpha particle diagnostic, and current and density profile diagnostics. This paper discusses research in all these topics.

  17. WHO Child Growth Standards Are Often Incorrectly Applied to Children Born Preterm in Epidemiologic Research. (United States)

    Perumal, Nandita; Gaffey, Michelle F; Bassani, Diego G; Roth, Daniel E


    In epidemiologic research, there is no standard approach for accounting for gestational age (GA) at birth when interpreting postnatal anthropometric data in analyses of cohorts that include children born preterm (CBP). A scoping review was conducted to describe analytical approaches to account for GA at birth when applying the WHO Growth Standards (WHO-GS) to anthropometric data in epidemiologic studies. We searched PubMed, Scopus, MEDLINE, Embase, and Web of Science for studies that applied WHO-GS, included CBP in the study population, had access to data within 1 mo of age, and were published between 2006 and 2015 in English. Of the 80 included studies that used the WHO-GS, 80% (64 of 80) included all children regardless of GA, whereas 20% (16 of 80) restricted analyses that used WHO-GS to term-born children. Among the 64 studies that included all children, 53 (83%) used chronological age and 11 (17%) used corrected age for CBP. Of the 53 studies that used chronological age, 12 (23%) excluded data that were likely contributed by CBP (e.g., very low birth weight or extremely low outlying z scores) and 19 (36%) adjusted for or stratified by GA at birth in regression analyses. In summary, researchers commonly apply WHO-GS to CBP, usually based on chronological age. Methodologic challenges of analyzing data from CBP in the application of WHO-GS were rarely explicitly addressed. Further efforts are required to establish acceptable approaches to account for heterogeneity in GA at birth in the analysis of post-term anthropometric data in epidemiologic research.

  18. Collaborative applied research programs at AITF

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    Chow, Ross [Alberta Innovates Technology Futures (Canada)


    Alberta Innovates Technology Futures (AITF) is a 600 employee company created in 2010 and owned by the Alberta government; offices are located in Edmonton, Devon, Vegreville and Calgary. The purpose of this document is to present the services provided by AITF. The company provides technical support and advisory services as well as commercialization support, they provide the link between the concept stage and the commercialization stage. AITF proposes collaborative programs which can be consortia made up of a series of projects on general industry issues or joint industry projects which focus on a specific issue. During this presentation, a joint industry project, the fuels and lubricants exchange program, was presented along with several consortia such as the carbonate research program, the materials and reliability in oil sands program, and the AACI program. This presentation highlighted the work carried out by AITF to meet the needs of their clients.

  19. International Biological Engagement Programs Facilitate Newcastle Disease Epidemiological Studies (United States)

    Miller, Patti J.; Dimitrov, Kiril M.; Williams-Coplin, Dawn; Peterson, Melanie P.; Pantin-Jackwood, Mary J.; Swayne, David E.; Suarez, David L.; Afonso, Claudio L.


    Infections of poultry species with virulent strains of Newcastle disease virus (NDV) cause Newcastle disease (ND), one of the most economically significant and devastating diseases for poultry producers worldwide. Biological engagement programs between the Southeast Poultry Research Laboratory (SEPRL) of the United States Department of Agriculture and laboratories from Russia, Pakistan, Ukraine, Kazakhstan, and Indonesia collectively have produced a better understanding of the genetic diversity and evolution of the viruses responsible for ND, which is crucial for the control of the disease. The data from Kazakhstan, Russia, and Ukraine identified possible migratory routes for birds that may carry both virulent NDV (vNDV) and NDV of low virulence into Europe. In addition, related NDV strains were isolated from wild birds in Ukraine and Nigeria, and from birds in continental USA, Alaska, Russia, and Japan, identifying wild birds as a possible mechanism of intercontinental spread of NDV of low virulence. More recently, the detection of new sub-genotypes of vNDV suggests that a new, fifth, panzootic of ND has already originated in Southeast Asia, extended to the Middle East, and is now entering into Eastern Europe. Despite expected challenges when multiple independent laboratories interact, many scientists from the collaborating countries have successfully been trained by SEPRL on molecular diagnostics, best laboratory practices, and critical biosecurity protocols, providing our partners the capacity to further train other employes and to identify locally the viruses that cause this OIE listed disease. These and other collaborations with partners in Mexico, Bulgaria, Israel, and Tanzania have allowed SEPRL scientists to engage in field studies, to elucidate more aspects of ND epidemiology in endemic countries, and to understand the challenges that the scientists and field veterinarians in these countries face on a daily basis. Finally, new viral characterization tools

  20. Applied programs at Brookhaven National Laboratory

    Energy Technology Data Exchange (ETDEWEB)


    This document overviews the areas of current research at Brookhaven National Laboratory. Technology transfer and the user facilities are discussed. Current topics are presented in the areas of applied physics, chemical science, material science, energy efficiency and conservation, environmental health and mathematics, biosystems and process science, oceanography, and nuclear energy. (GHH)

  1. [Epidemiologic survey of teniasis in Health and Family Program in Uberaba, MG]. (United States)

    Esteves, Flavia Maria; Silva-Vergara, Mario León; Carvalho, Angela C F Banzatto de


    An epidemiologic survey was carried out on 110,144 people from the Health Family Program to evaluate some Epidemiologic aspects of teniasis. Previous history of passing proglottides was registered in 185 (0.2%) of them, and 112 (60.5%) received praziquantel. After this 97 (86.6%) passed proglottides characterized as Taenia Saginata and Taenia Solium in 36 (37.1%) and 4 (4.1%) respectively.

  2. Applying quality criteria to exposure in asbestos epidemiology increases the estimated risk. (United States)

    Burdorf, Alex; Heederik, Dick


    Mesothelioma deaths due to environmental exposure to asbestos in The Netherlands led to parliamentary concern that exposure guidelines were not strict enough. The Health Council of the Netherlands was asked for advice. Its report has recently been published. The question of quality of the exposure estimates was studied more systematically than in previous asbestos meta-analyses. Five criteria of quality of exposure information were applied, and cohort studies that failed to meet these were excluded. For lung cancer, this decreased the number of cohorts included from 19 to 3 and increased the risk estimate 3- to 6-fold, with the requirements for good historical data on exposure and job history having the largest effects. It also suggested that the apparent differences in lung cancer potency between amphiboles and chrysotile may be produced by lower quality studies. A similar pattern was seen for mesothelioma. As a result, the Health Council has proposed that the occupational exposure limit be reduced from 10 000 fibres m(-3) (all types) to 250 f m(-3) (amphiboles), 1300 f m(-3) (mixed fibres), and 2000 f m(-3) (chrysotile). The process illustrates the importance of evaluating quality of exposure in epidemiology since poor quality of exposure data will lead to underestimated risk.

  3. Frontiers in cancer epidemiology: a challenge to the research community from the Epidemiology and Genomics Research Program at the National Cancer Institute. (United States)

    Khoury, Muin J; Freedman, Andrew N; Gillanders, Elizabeth M; Harvey, Chinonye E; Kaefer, Christie; Reid, Britt C; Rogers, Scott; Schully, Sheri D; Seminara, Daniela; Verma, Mukesh


    The Epidemiology and Genomics Research Program (EGRP) at the National Cancer Institute (NCI) is developing scientific priorities for cancer epidemiology research in the next decade. We would like to engage the research community and other stakeholders in a planning effort that will include a workshop in December 2012 to help shape new foci for cancer epidemiology research. To facilitate the process of defining the future of cancer epidemiology, we invite the research community to join in an ongoing web-based conversation at to develop priorities and the next generation of high-impact studies.

  4. [The capture-recapture applied to epidemiology: principles, limits and application]. (United States)

    Gallay, A; Nardone, A; Vaillant, V; Desenclos, J C


    By matching several sources of information coming from the same population, the capture-recapture method allows, if matches between sources can be identified, to estimate the number of cases not identified by any of the sources, the total number (N) of cases in the population and the sensitivity of each source. Used first in zoology and demography, this technique has been increasingly applied to epidemiology in the last two decades. However, six conditions need to be satisfied: all cases identified by each source are true cases; occurred during the time and the geographical area studied; the study population is closed; all matches are true matches; sources are independent and there is no heterogeneous catchability within sources. It is possible to assess and take into account dependence between sources when 3 or more sources are used, in particular by log linear modelling. However interactions of maximal order cannot be adjusted for. In case of a biased estimation because of the non respect of the conditions, it is recommended to apply a method of correction. The complete application of the methods is illustrated in the study of estimating the number of Salmonella infectious foodborne outbreak. As capture-recapture studies often use data collected for other purposes, this technique should be regarded as exploratory or be used to validate an estimate of a number of cases obtained by another method. It should not replace population sampling methods only because of its low cost. Otherwise it is a very informative approach to evaluate the sensitivity and representativeness of surveillance systems and registries.

  5. Implementation of dermato-epidemiology curriculum at Case Western Reserve University dermatology program. (United States)

    Barzilai, David A; Mikkilineni, Radha; Davis, Bryan R; Stevens, Seth R; Mostow, Eliot N


    Dermato-epidemiology curriculum has been identified by the American Academy of Dermatology (AAD) as an important foundation for dermatology residency training. However, no one has yet reported implementation of dermato-epidemiology curriculum. To evaluate and relate our experience carrying out a dermato-epidemiology resident education initiative, based on recommendations by the AAD Epidemiology Committee. Monthly lectures based on topics suggested by the AAD Epidemiology Curriculum. Pre- and post-test multiple choice and free-form question measures were employed to examine performance, assess resident enthusiasm, and solicit feedback from the initiative. Quantitative achievement on multiple-choice items improved slightly, but insignificantly, from 53 percent to 58 percent. Resident level of enthusiasm and perceived efficacy for the intervention varied from 3.3 to 4.0 on a 5-point Likert scale where "1" indicates strongly disagree and "5" indicates strongly agree with measures of effectiveness. Dermato-epidemiology curriculum is desirable and achievable even in dermatology programs without full-time epidemiologists. A successful epidemiology curriculum should be clinically and board-examination relevant, incorporating aspects of problem-based, interactive learning.

  6. Variation Theory Applied to Students' Conceptions of Computer Programming (United States)

    Thune, Michael; Eckerdal, Anna


    The present work has its focus on university-level engineering education students that do not intend to major in computer science but still have to take a mandatory programming course. Phenomenography and variation theory are applied to empirical data from a study of students' conceptions of computer programming. A phenomenographic outcome space…

  7. Designing a New Program in Family Relations and Applied Nutrition (United States)

    Devine, Sharon Mayne; Daly, Kerry; Lero, Donna; MacMartin, Clare


    Family Relations and Applied Nutrition, which is offered at the University of Guelph, is an interdisciplinary department that previously offered three undergraduate majors: child, youth, and family; applied human nutrition; and gerontology; as well as graduate programs at the master's and doctoral levels. Several factors have precipitated a review…

  8. Simulating Nationwide Pandemics: Applying the Multi-scale Epidemiologic Simulation and Analysis System to Human Infectious Diseases

    Energy Technology Data Exchange (ETDEWEB)

    Dombroski, M; Melius, C; Edmunds, T; Banks, L E; Bates, T; Wheeler, R


    This study uses the Multi-scale Epidemiologic Simulation and Analysis (MESA) system developed for foreign animal diseases to assess consequences of nationwide human infectious disease outbreaks. A literature review identified the state of the art in both small-scale regional models and large-scale nationwide models and characterized key aspects of a nationwide epidemiological model. The MESA system offers computational advantages over existing epidemiological models and enables a broader array of stochastic analyses of model runs to be conducted because of those computational advantages. However, it has only been demonstrated on foreign animal diseases. This paper applied the MESA modeling methodology to human epidemiology. The methodology divided 2000 US Census data at the census tract level into school-bound children, work-bound workers, elderly, and stay at home individuals. The model simulated mixing among these groups by incorporating schools, workplaces, households, and long-distance travel via airports. A baseline scenario with fixed input parameters was run for a nationwide influenza outbreak using relatively simple social distancing countermeasures. Analysis from the baseline scenario showed one of three possible results: (1) the outbreak burned itself out before it had a chance to spread regionally, (2) the outbreak spread regionally and lasted a relatively long time, although constrained geography enabled it to eventually be contained without affecting a disproportionately large number of people, or (3) the outbreak spread through air travel and lasted a long time with unconstrained geography, becoming a nationwide pandemic. These results are consistent with empirical influenza outbreak data. The results showed that simply scaling up a regional small-scale model is unlikely to account for all the complex variables and their interactions involved in a nationwide outbreak. There are several limitations of the methodology that should be explored in future

  9. The Graduate Internship Program in Applied Medical Sociology. (United States)

    Hoppe, Sue Keir; Barr, Judith K.


    Reviews the history, goals, achievements, and future of a graduate internship program sponsored by the Medical Sociology Section of the American Sociological Association. Students are placed in internships in a variety of clinical and research areas concerned with the development of health policy and careers in applied medical sociology. (NL)

  10. Environmental epidemiology applied to urban atmospheric pollution: a contribution from the Experimental Air Pollution Laboratory (LPAE

    Directory of Open Access Journals (Sweden)

    André Paulo Afonso de


    Full Text Available Systematic investigation on the effects of human exposure to environmental pollution using scientific methodology only began in the 20th century as a consequence of several environmental accidents followed by an unexpected mortality increase above expected mortality and as a result of observational epidemiological and toxicological studies conducted on animals in developed countries. This article reports the experience of the Experimental Air Pollution Laboratory at the School of Medicine, University of São Paulo, concerning the respiratory system and pathophysiological mechanisms involved in responses to exposure to pollution using toxicological and experimental procedures, complemented by observational epidemiological studies conducted in the city of São Paulo. It also describes these epidemiological studies, pointing out that air pollution is harmful to public health, not only among susceptible groups but also in the general population, even when the concentration of pollutants is below the limits set by environmental legislation. The study provides valuable information to support the political and economic decision-making processes aimed at preserving the environment and enhancing quality of life.

  11. Reasons of Teachers for Applying for Graduate Programs and Their Expectations from Programs (United States)

    Burgaz, Berrin; Kocak, Seval


    This study aims to find out teachers' motivation for applying for graduate programs and to explore their expectations from the programs and their ideas regarding the necessity of such programs for teachers. The paper is based on a qualitative research method and draws its data from focus group interviews. The study used the criterion sampling…

  12. Applied Science Division annual report, Environmental Research Program FY 1983

    Energy Technology Data Exchange (ETDEWEB)

    Cairns, E.J.; Novakov, T.


    The primary concern of the Environmental Research Program is the understanding of pollutant formation, transport, and transformation and the impacts of pollutants on the environment. These impacts include global, regional, and local effects on the atmosphere and hydrosphere, and on certain aspects of human health. This multidisciplinary research program includes fundamental and applied research in physics, chemistry, engineering, and biology, as well as research on the development of advanced methods of measurement and analysis. During FY 1983, research concentrated on atmospheric physics and chemistry, applied physics and laser spectroscopy, combustion theory and phenomena, environmental effects of oil shale processing, freshwater ecology and acid precipitation, trace element analysis for the investigation of present and historical environmental impacts, and a continuing survey of instrumentation for environmental monitoring.

  13. Applying Logic Programming to Knowledge Discovery on the Internet

    Institute of Scientific and Technical Information of China (English)


    LP (Logic Programming) has been successfully applied to knowledgediscovery in many fields. The execution of the LP is based on the evaluation of the first or der predicate. Usually the information involved in the predicates are local and homogenous, thus the evaluation process is relatively simple. However, the evalu ation process become much more complicated when applied to KDD on the Internet w here the information involved in the predicates maybe heterogeneous and distribu ted over many different sits. Therefor, we try to attack the problem in a multi - agent system's framework so that the logic program can be written in a site-ind ependent style and deal easily with heterogeneous represented information.

  14. The causal pie model: an epidemiological method applied to evolutionary biology and ecology. (United States)

    Wensink, Maarten; Westendorp, Rudi G J; Baudisch, Annette


    A general concept for thinking about causality facilitates swift comprehension of results, and the vocabulary that belongs to the concept is instrumental in cross-disciplinary communication. The causal pie model has fulfilled this role in epidemiology and could be of similar value in evolutionary biology and ecology. In the causal pie model, outcomes result from sufficient causes. Each sufficient cause is made up of a "causal pie" of "component causes". Several different causal pies may exist for the same outcome. If and only if all component causes of a sufficient cause are present, that is, a causal pie is complete, does the outcome occur. The effect of a component cause hence depends on the presence of the other component causes that constitute some causal pie. Because all component causes are equally and fully causative for the outcome, the sum of causes for some outcome exceeds 100%. The causal pie model provides a way of thinking that maps into a number of recurrent themes in evolutionary biology and ecology: It charts when component causes have an effect and are subject to natural selection, and how component causes affect selection on other component causes; which partitions of outcomes with respect to causes are feasible and useful; and how to view the composition of a(n apparently homogeneous) population. The diversity of specific results that is directly understood from the causal pie model is a test for both the validity and the applicability of the model. The causal pie model provides a common language in which results across disciplines can be communicated and serves as a template along which future causal analyses can be made.

  15. Replicating MISTERS: an epidemiological criminology framework analysis of a program for criminal justice-involved minority males in the community. (United States)

    Potter, Roberto Hugh; Akers, Timothy A; Bowman, Daniel Richard


    The Men in STD Training and Empowerment Research Study (MISTERS) program and epidemiological criminology began their development in Atlanta at about the same time. MISTERS focuses on men recently released from jail to reduce both HIV/STD and crime-related risk factors through a brief educational intervention. This article examines ways in which MISTERS and epidemiological criminology have been used to inform one another in the replication of the MISTERS program in Orange County, Florida. Data from 110 MISTERS participants during the first 10 months of operation are analyzed to examine the overlapping occurrence of health and criminal risk behaviors in the men's lives. This provides a test of core hypotheses from the epidemiological criminology framework. This article also examines application of the epidemiological criminology framework to develop interventions to address health and crime risk factors simultaneously in Criminal Justice-Involved populations in the community.

  16. The "Pathological Gambling and Epidemiology" (PAGE) study program: design and fieldwork. (United States)

    Meyer, Christian; Bischof, Anja; Westram, Anja; Jeske, Christine; de Brito, Susanna; Glorius, Sonja; Schön, Daniela; Porz, Sarah; Gürtler, Diana; Kastirke, Nadin; Hayer, Tobias; Jacobi, Frank; Lucht, Michael; Premper, Volker; Gilberg, Reiner; Hess, Doris; Bischof, Gallus; John, Ulrich; Rumpf, Hans-Jürgen


    The German federal states initiated the "Pathological Gambling and Epidemiology" (PAGE) program to evaluate the public health relevance of pathological gambling. The aim of PAGE was to estimate the prevalence of pathological gambling and cover the heterogenic presentation in the population with respect to comorbid substance use and mental disorders, risk and protective factors, course aspects, treatment utilization, triggering and maintenance factors of remission, and biological markers. This paper describes the methodological details of the study and reports basic prevalence data. Two sampling frames (landline and mobile telephone numbers) were used to generate a random sample from the general population consisting of 15,023 individuals (ages 14 to 64) completing a telephone interview. Additionally, high-risk populations have been approached in gambling locations, via media announcements, outpatient addiction services, debt counselors, probation assistants, self-help groups and specialized inpatient treatment facilities. The assessment included two steps: (1) a diagnostic interview comprising the gambling section of the Composite International Diagnostic Interview (CIDI) for case finding; (2) an in-depth clinical interview with participants reporting gambling problems. The in-depth clinical interview was completed by 594 participants, who were recruited from the general or high-risk populations. The program provides a rich epidemiological database which is available as a scientific use file.

  17. Notas sobre a segunda avaliação externa do programa de treinamento em epidemiologia aplicada aos serviços do sistema único de saúde do Brasil - EPISUS: potencialidades do enfoque qualitativo-participativo Notes on the second external evaluation of the training program in epidemiology applied to the services of brazil's national health system - EPISUS: potentialities of the qualitative-participatory approach

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Magalhães Bosi


    Full Text Available Este trabalho objetiva relatar o emprego do enfoque qualitativo-participativo, bem como discutir seus fundamentos e potencialidades, tomando como base a participação dos autores na segunda avaliação externa do Programa de Treinamento em Epidemiologia Aplicada aos Serviços do Sistema Único de Saúde - EPISUS. Finalizada em outubro de 2007, em parceria com a Secretaria de Vigilância em Saúde e o Center for Diseases Control (CDC/Atlanta, a referida avaliação incorporou o enfoque da chamada quarta geração (fourth generation evaluation, no qual os avaliadores operam como mediadores, substituindo, assim, os fundamentos do enfoque tradicional antes utilizado. Para tanto, tornou-se necessária uma demarcação conceitual referente aos conceitos avaliação, qualitativo e participativo que orientariam o processo avaliativo focalizado. Quanto ao conceito avaliação, sua natureza conflui para as propostas de quarta geração e, portanto, transita de um caráter punitivo para um caráter construtivo. A dimensão participativa aponta para diferentes sentidos do que seja participar e, na experiência aqui relatada, adotou-se o sentido decisório, onde se busca reverter assimetrias de poder. O qualitativo é concebido na interface com a subjetividade, referindo-se a informações que não se submetem à quantificação. Tal modelo permitiu desvelar aspectos que, muitas vezes, se ocultam nos números e nas generalizações abstratas, tornando possível focalizar as relações que constituem o cotidiano dos programas e práticas em saúde, subsidiando, assim, sua transformação.This paper aims to present the authors' experience concerning the use of the qualitative-participatory approach in the second external evaluation of the Training Program in Epidemiology Applied to the Services of the National Health System - EPISUS. Completed in October 2007, in partnership with the Health Surveillance Department and the Center for Diseases Control (CDC

  18. Applying national survey results for strategic planning and program improvement: the National Diabetes Education Program. (United States)

    Griffey, Susan; Piccinino, Linda; Gallivan, Joanne; Lotenberg, Lynne Doner; Tuncer, Diane


    Since the 1970s, the federal government has spearheaded major national education programs to reduce the burden of chronic diseases in the United States. These prevention and disease management programs communicate critical information to the public, those affected by the disease, and health care providers. The National Diabetes Education Program (NDEP), the leading federal program on diabetes sponsored by the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC), uses primary and secondary quantitative data and qualitative audience research to guide program planning and evaluation. Since 2006, the NDEP has filled the gaps in existing quantitative data sources by conducting its own population-based survey, the NDEP National Diabetes Survey (NNDS). The NNDS is conducted every 2–3 years and tracks changes in knowledge, attitudes and practice indicators in key target audiences. This article describes how the NDEP has used the NNDS as a key component of its evaluation framework and how it applies the survey results for strategic planning and program improvement. The NDEP's use of the NNDS illustrates how a program evaluation framework that includes periodic population-based surveys can serve as an evaluation model for similar national health education programs.

  19. Applying Best Practices to Florida Local Government Retrofit Programs

    Energy Technology Data Exchange (ETDEWEB)

    McIlvaine, J.; Sutherland, K.


    In some communities, local government and non-profit entities have funds to purchase and renovate distressed, foreclosed homes for resale in the affordable housing market. Numerous opportunities to improve whole house energy efficiency are inherent in these comprehensive renovations. BA-PIRC worked together in a multi-year field study making recommendations in individual homes, meanwhile compiling improvement costs, projected energy savings, practical challenges, and labor force factors surrounding common energy-related renovation measures. The field study, Phase 1 of this research, resulted in a set of best practices appropriate to the current labor pool and market conditions in central Florida to achieve projected annual energy savings of 15-30% and higher. This report describes Phase 2 of the work where researchers worked with a local government partner to implement and refine the 'current best practices.' A simulation study was conducted to characterize savings potential under three sets of conditions representing varying replacement needs for energy-related equipment and envelope components. The three scenarios apply readily to the general remodeling industry as for renovation of foreclosed homes for the affordable housing market. Our new local government partner, the City of Melbourne, implemented the best practices in a community-scale renovation program that included ten homes in 2012.

  20. Applying Best Practices to Florida Local Government Retrofit Programs

    Energy Technology Data Exchange (ETDEWEB)

    McIlvaine, J. [Building America Partnership for Improved Residential Construction (BA-PIRC), Cocoa, FL (United States); Sutherland, K. [Building America Partnership for Improved Residential Construction (BA-PIRC), Cocoa, FL (United States)


    In some communities, local government and non-profit entities have funds to purchase and renovate distressed, foreclosed homes for resale in the affordable housing market. Numerous opportunities to improve whole house energy efficiency are inherent in these comprehensive renovations. BA-PIRC worked together in a multiyear field study making recommendations in individual homes, meanwhile compiling improvement costs, projected energy savings, practical challenges, and labor force factors surrounding common energy-related renovation measures. The field study, Phase 1 of this research, resulted in a set of best practices appropriate to the current labor pool and market conditions in central Florida to achieve projected annual energy savings of 15%-30% and higher. This report describes Phase 2 of the work where researchers worked with a local government partner to implement and refine the "current best practices". A simulation study was conducted to characterize savings potential under three sets of conditions representing varying replacement needs for energy-related equipment and envelope components. The three scenarios apply readily to the general remodeling industry as for renovation of foreclosed homes for the affordable housing market. The new local government partner, the City of Melbourne, implemented the best practices in a community-scale renovation program that included ten homes in 2012.

  1. 34 CFR 403.1 - What is the State Vocational and Applied Technology Education Program? (United States)


    ... 34 Education 3 2010-07-01 2010-07-01 false What is the State Vocational and Applied Technology... TECHNOLOGY EDUCATION PROGRAM General § 403.1 What is the State Vocational and Applied Technology Education Program? (a) Under the State Vocational and Applied Technology Education Program, the Secretary...

  2. 34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs? (United States)


    ... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act,...

  3. 34 CFR 400.3 - What other regulations apply to the Vocational and Applied Technology Education Programs? (United States)


    ... Education, Hospitals, and Nonprofit Organizations). (2) 34 CFR part 75 (Direct Grant Programs) (applicable...) (applicable to parts 403, 406, and 407). (4) 34 CFR part 77 (Definitions that Apply to Department...

  4. Applying Medical Anthropology: Developing Diabetes Education and Prevention Programs in American Indian Cultures. (United States)

    Olson, Brooke


    Medical anthropology provides a broader contextual framework for understanding complex causal factors associated with diabetes among American Indians and how to minimize these factors in education/treatment programs. Discusses historical, epidemiological, and genetic considerations in American Indian diabetes; cultural factors related to foods,…

  5. Rheumatology in India: a Bird's Eye View on Organization, Epidemiology, Training Programs and Publications. (United States)

    Misra, Durga Prasanna; Agarwal, Vikas; Negi, Vir Singh


    India is home to the world's second largest population. Rheumatology is an emerging specialty in India. We reviewed organization, epidemiology and training facilities for Rheumatology in India. Also, we also looked at publications in the field of rheumatology from India from over the past six years using Scopus and Medline databases. Despite rheumatologic disorders affecting 6%-24% of the population, rheumatology in India is still in its infancy. Till recently, there were as few as two centers in the country training less than five fellows per year. However, acute shortage of specialists and increasing patient numbers led to heightened awareness regarding the need to train rheumatologists. Subsequently, six new centers have now started 3-year training programs in rheumatology. The epidemiology of rheumatic diseases in India is being actively studies under the Community Oriented Programme for Control of Rheumatic Diseases (COPCORD) initiative. The most number of publications on rheumatic diseases from India are on rheumatoid arthritis, lupus and osteoporosis, many of which have been widely cited. Major collaborators worldwide are USA, UK and France, whereas those from Asia are Japan, Saudi Arabia and Singapore. The Indian Rheumatology Association (IRA) is the national organization of rheumatologists. The flagship publication of the IRA, the Indian Journal of Rheumatology, is indexed in Scopus and Embase. To conclude, rheumatology in India is an actively expanding and productive field with significant contributions to world literature. There is a need to train more personnel in the subject in India.

  6. An interactive parallel programming environment applied in atmospheric science (United States)

    vonLaszewski, G.


    This article introduces an interactive parallel programming environment (IPPE) that simplifies the generation and execution of parallel programs. One of the tasks of the environment is to generate message-passing parallel programs for homogeneous and heterogeneous computing platforms. The parallel programs are represented by using visual objects. This is accomplished with the help of a graphical programming editor that is implemented in Java and enables portability to a wide variety of computer platforms. In contrast to other graphical programming systems, reusable parts of the programs can be stored in a program library to support rapid prototyping. In addition, runtime performance data on different computing platforms is collected in a database. A selection process determines dynamically the software and the hardware platform to be used to solve the problem in minimal wall-clock time. The environment is currently being tested on a Grand Challenge problem, the NASA four-dimensional data assimilation system.

  7. The DEVELOP Program as a Unique Applied Science Internship (United States)

    Skiles, J. W.; Schmidt, C. L.; Ruiz, M. L.; Cawthorn, J.


    The NASA mission includes "Inspiring the next generation of explorers" and "Understanding and protecting our home planet". DEVELOP students conduct research projects in Earth Systems Science, gaining valuable training and work experience, which support accomplishing this mission. This presentation will describe the DEVELOP Program, a NASA human capital development initiative, which is student run and student led with NASA scientists serving as mentors. DEVELOP began in 1998 at NASA's Langley Research Center in Virginia and expanded to NASA's Stennis Space Center in Mississippi and Marshall Space Flight Center in Alabama in 2002. NASA's Ames Research Center in California began DEVELOP activity in 2003. DEVELOP is a year round activity. High school through graduate school students participate in DEVELOP with students' backgrounds encompassing a wide variety of academic majors such as engineering, biology, physics, mathematics, computer science, remote sensing, geographic information systems, business, and geography. DEVELOP projects are initiated when county, state, or tribal governments submit a proposal requesting students work on local projects. When a project is selected, science mentors guide students in the application of NASA applied science and technology to enhance decision support tools for customers. Partnerships are established with customers, professional organizations and state and federal agencies in order to leverage resources needed to complete research projects. Student teams are assigned a project and are responsible for creating an inclusive project plan beginning with the design and approach of the study, the timeline, and the deliverables for the customer. Project results can consist of student papers, both team and individually written, face-to-face meetings and seminars with customers, presentations at national meetings in the form of posters and oral papers, displays at the Western and Southern Governors' Associations, and visualizations

  8. The NASA Applied Sciences Program: Volcanic Ash Observations and Applications (United States)

    Murray, John J.; Fairlie, Duncan; Green, David; Haynes, John; Krotkov, Nickolai; Meyer, Franz; Pavolonis, Mike; Trepte, Charles; Vernier, Jean-Paul


    Since 2000, the NASA Applied Sciences Program has been actively transitioning observations and research to operations. Particular success has been achieved in developing applications for NASA Earth Observing Satellite (EOS) sensors, integrated observing systems, and operational models for volcanic ash detection, characterization, and transport. These include imager applications for sensors such as the MODerate resolution Imaging SpectroRadiometer (MODIS) on NASA Terra and Aqua satellites, and the Visible Infrared Imaging Radiometer Suite (VIIRS) on the NASA/NOAA Suomi NPP satellite; sounder applications for sensors such as the Atmospheric Infrared Sounder (AIRS) on Aqua, and the Cross-track Infrared Sounder (CrIS) on Suomi NPP; UV applications for the Ozone Mapping Instrument (OMI) on the NASA Aura Satellite and the Ozone Mapping Profiler Suite (OMPS) on Suomi NPP including Direct readout capabilities from OMI and OMPS in Alaska (GINA) and Finland (FMI):; and lidar applications from the Caliop instrument coupled with the imaging IR sensor on the NASA/CNES CALIPSO satellite. Many of these applications are in the process of being transferred to the Washington and Alaska Volcanic Ash Advisory Centers (VAAC) where they support operational monitoring and advisory services. Some have also been accepted, transitioned and adapted for direct, onboard, automated product production in future U.S. operational satellite systems including GOES-R, and in automated volcanic cloud detection, characterization and alerting tools at the VAACs. While other observations and applications remain to be developed for the current constellation of NASA EOS sensors and integrated with observing and forecast systems, future requirements and capabilities for volcanic ash observations and applications are also being developed. Many of these are based on technologies currently being tested on NASA aircraft, Unmanned Aerial Systems (UAS) and balloons. All of these efforts and the potential advances

  9. [A review of thirty years of activity of the Research Program in Psychiatric Epidemiology (PEPSI) of the CONICET]. (United States)

    Pavlovsky, Federico


    This article summarizes the activity of the Programa de Investigaciones en Epidemiología Psiquiátrica (PEPSI) (Research Program in Psychiatric Epidemiology) of the CONICET, directed for more than thirty years by Fernando Pages Larraya. After an anthropologic psychiatric experience done in the Gran Chaco Gualamba, by the end of the 60s, Pages Larraya and his team developed the theory of Cultural Isoidias, zones into which the country could be divided for epidemiologic studies. This article summarizes some of the principal lines of investigation of this program which departures from an initial study of the prevalence of mental diseases in Argentina. Other lines of research (such as a study about marginality, about Alzheimer's disease, about alcoholism and about AIDS) are summarized very briefly so as to give the reader an idea about the enormous field of study embraced by the PEPSI.

  10. Consideration of an applied model of public health program infrastructure. (United States)

    Lavinghouze, René; Snyder, Kimberly; Rieker, Patricia; Ottoson, Judith


    Systemic infrastructure is key to public health achievements. Individual public health program infrastructure feeds into this larger system. Although program infrastructure is rarely defined, it needs to be operationalized for effective implementation and evaluation. The Ecological Model of Infrastructure (EMI) is one approach to defining program infrastructure. The EMI consists of 5 core (Leadership, Partnerships, State Plans, Engaged Data, and Managed Resources) and 2 supporting (Strategic Understanding and Tactical Action) elements that are enveloped in a program's context. We conducted a literature search across public health programs to determine support for the EMI. Four of the core elements were consistently addressed, and the other EMI elements were intermittently addressed. The EMI provides an initial and partial model for understanding program infrastructure, but additional work is needed to identify evidence-based indicators of infrastructure elements that can be used to measure success and link infrastructure to public health outcomes, capacity, and sustainability.

  11. 42 CFR 62.3 - Who is eligible to apply for a scholarship program award? (United States)


    ... 42 Public Health 1 2010-10-01 2010-10-01 false Who is eligible to apply for a scholarship program... FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL HEALTH SERVICE CORPS SCHOLARSHIP AND LOAN REPAYMENT PROGRAMS National Health Service Corps Scholarship Program § 62.3 Who is eligible to apply for a scholarship...

  12. Constraint-based scheduling applying constraint programming to scheduling problems

    CERN Document Server

    Baptiste, Philippe; Nuijten, Wim


    Constraint Programming is a problem-solving paradigm that establishes a clear distinction between two pivotal aspects of a problem: (1) a precise definition of the constraints that define the problem to be solved and (2) the algorithms and heuristics enabling the selection of decisions to solve the problem. It is because of these capabilities that Constraint Programming is increasingly being employed as a problem-solving tool to solve scheduling problems. Hence the development of Constraint-Based Scheduling as a field of study. The aim of this book is to provide an overview of the most widely used Constraint-Based Scheduling techniques. Following the principles of Constraint Programming, the book consists of three distinct parts: The first chapter introduces the basic principles of Constraint Programming and provides a model of the constraints that are the most often encountered in scheduling problems. Chapters 2, 3, 4, and 5 are focused on the propagation of resource constraints, which usually are responsibl...

  13. Field Epidemiology and Laboratory Training Programs in West Africa as a model for sustainable partnerships in animal and human health. (United States)

    Becker, Karen M; Ohuabunwo, Chima; Ndjakani, Yassa; Nguku, Patrick; Nsubuga, Peter; Mukanga, David; Wurapa, Frederick


    The concept of animal and human health experts working together toward a healthier world has been endorsed, but challenges remain in identifying concrete actions to move this one health concept from vision to action. In 2008, as a result of avian influenza outbreaks in West Africa, international donor support led to a unique opportunity to invest in Field Epidemiology and Laboratory Training Programs (FELTPs) in the region that engaged the animal and human health sectors to strengthen the capacity for prevention and control of zoonotic diseases. The FELTPs mixed 25% to 35% classroom and 65% to 75% field-based training and service for cohorts of physicians, veterinarians, and laboratory scientists. They typically consisted of a 2-year course leading to a master's degree in field epidemiology and public health laboratory management for midlevel public health leaders and competency-based short courses for frontline public health surveillance workers. Trainees and graduates work in multidisciplinary teams to conduct surveillance, outbreak investigations, and epidemiological studies for disease control locally and across borders. Critical outcomes of these programs include development of a cadre of public health leaders with core skills in integrated disease surveillance, outbreak investigation, vaccination campaigns, laboratory diagnostic testing, and epidemiological studies that address priority public health problems. A key challenge exists in identifying ways to successfully scale up and transform this innovative donor-driven program into a sustainable multisectoral one health workforce capacity development model.

  14. Applying Model Checking to Industrial-Sized PLC Programs

    CERN Document Server

    AUTHOR|(CDS)2079190; Darvas, Daniel; Blanco Vinuela, Enrique; Tournier, Jean-Charles; Bliudze, Simon; Blech, Jan Olaf; Gonzalez Suarez, Victor M


    Programmable logic controllers (PLCs) are embedded computers widely used in industrial control systems. Ensuring that a PLC software complies with its specification is a challenging task. Formal verification has become a recommended practice to ensure the correctness of safety-critical software but is still underused in industry due to the complexity of building and managing formal models of real applications. In this paper, we propose a general methodology to perform automated model checking of complex properties expressed in temporal logics (\\eg CTL, LTL) on PLC programs. This methodology is based on an intermediate model (IM), meant to transform PLC programs written in various standard languages (ST, SFC, etc.) to different modeling languages of verification tools. We present the syntax and semantics of the IM and the transformation rules of the ST and SFC languages to the nuXmv model checker passing through the intermediate model. Finally, two real cases studies of \\CERN PLC programs, written mainly in th...

  15. Epidemiologic aspects of neural tube defects in the United States: changing concepts and their importance for screening and prenatal diagnostic programs

    Energy Technology Data Exchange (ETDEWEB)

    Sever, L.E.; Strassburg, M.A.


    This report considers several major epidemiologic aspects of neural tube defects (NTDs). After examining briefly the approaches and goals of epidemiology the traditional epidemiologic concepts of NTDs are reviewed and new interpretations of the epidemiology of these defects is suggested. Three major topics are addressed: (1) that much of our knowledge of the epidemiology of the NTDs comes from areas or periods of high rates of occurrence and that generalizations based on these data may not be applicable to low incidence situations; (2) that the etiology of these defects is multifactorial, involving interaction between genetic and nongenetic factors which may differ in their relative importance between populations; and (3) that anencephalus and spina bifida may be more epidemiologically and etiologically distinct than is usually appreciated. A final consideration deals with some recent contributions of epidemiology to screening and prenatal diagnosis programs.

  16. [Determination of antibiotype by a computer program. Epidemiological significance and antibiogram-identification correlates]. (United States)

    Fosse, T; Macone, F; Laffont, C


    By means of a computer program disk diffusion diameter were analysed and an antibiotic susceptibility code (antibiotype) was determined for enterobacteriaceae. This code was a 6 figure-number. Each figure summarised susceptibility (susceptible or resistant) to 3 antibiotics. Thus a 18 serial antibiotics was necessary to calculate the 6 figure-code. At least following antibiotics were chosen for their characteristic behavior: amoxycillin, ticarcillin, amoxycillin + clavulanic acid, cephalothin, ticarcillin + clavulanic acid, cefotaxime, gentamycin, tobramycin, amikacin, nalidixic acid, pefloxacin, ciprofloxacin, fosfomycin and colistin. This code allowed three kind of utilisation: epidemiology by comparing biochemical and susceptibility patterns of same isolated species; laboratory control: a data base with main antibiotic susceptibility patterns for each species allowed a rapid compatibility control of biochemical identification with antibiogram. An inconsistent result lead to a checking of biochemical and susceptibility tests or to record a new code in a file to a further enrichment of the data base. Impression of a message depending of the code for a therapeutic purpose.

  17. 34 CFR 661.4 - What definitions apply to the Business and International Education Program? (United States)


    ... Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION BUSINESS AND INTERNATIONAL EDUCATION PROGRAM General § 661.4 What definitions apply to the Business and International Education Program... 34 Education 3 2010-07-01 2010-07-01 false What definitions apply to the Business...

  18. 13 CFR 101.106 - Does Federal law apply to SBA programs and activities? (United States)


    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Does Federal law apply to SBA programs and activities? 101.106 Section 101.106 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION ADMINISTRATION Overview § 101.106 Does Federal law apply to SBA programs and activities? (a)...

  19. 34 CFR 642.5 - Definitions that apply to the Training Program. (United States)


    ... 34 Education 3 2010-07-01 2010-07-01 false Definitions that apply to the Training Program. 642.5... Definitions that apply to the Training Program. (a) Definitions in EDGAR. The following terms used in this... Fiscal year Grant Grantee Nonprofit Private Project Project period Public Secretary State Supplies...

  20. Stochastic dynamic programming applied to planning of robot grinding tasks

    Energy Technology Data Exchange (ETDEWEB)

    Brown, M.L. (Digital Equipment Corp., Shrewsbury, MA (United States)); Whitney, D.E. (Massachusetts Inst. of Technology, Cambridge, MA (United States))


    This paper proposes an intelligent manufacturing system that can make decisions about the process in light of the uncertain outcome of these decisions and attempts to minimize the expected economic penalty resulting from those decisions. It uses robot weld bead grinding as an example of a process with significant process variations. The need for multiple grinding passes, the poor predictability of those passes, the task requirements, and the process constraints conspire to make planning and controlling weld bead grinding a formidable probe. A three tier hierarchical control system is proposed to plan an optimal sequence of grinding passes, dynamically simulate each pass, execute the planned sequence of controlled grinding passes, and modify the pass sequence as grinding continues. The top tier, described in this paper, plans the grinding sequence for each weld bead, and is implemented using Stochastic Dynamic Programming, selecting the volumetric removal and feedspeed for each pass in order to optimize the satisfaction of the task requirements by the entire grinding sequence within the equipment, task, and process constraints. The resulting optimal policies have quite complex structures, showing foresight, anxiety, indifference, and aggressiveness, depending upon the situation.

  1. Perceptions from a Preceptor in an Applied Medical Sociology Internship Program. (United States)

    Dolch, Norman A.


    Describes the supervision of internships in an applied medical sociology program. Participation covers three areas: (1) establishing a wellness program; (2) maintaining the program; and (3) responding to intern needs. Finds that monitoring interns requires a structure different from academic advising and instruction, and recommends treating…

  2. 34 CFR 655.3 - What regulations apply to the International Education Programs? (United States)


    ... Programs? 655.3 Section 655.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION INTERNATIONAL EDUCATION PROGRAMS... (Intergovernmental Review of Department of Education Programs and Activities), except that part 79 does not apply...

  3. 34 CFR 206.4 - What regulations apply to these programs? (United States)


    ...: (1) 34 CFR part 74 (Administration of Grants to Institutions of Higher Education, Hospitals, and... ENGAGED IN MIGRANT AND OTHER SEASONAL FARMWORK-HIGH SCHOOL EQUIVALENCY PROGRAM AND COLLEGE ASSISTANCE MIGRANT PROGRAM General § 206.4 What regulations apply to these programs? The following regulations...

  4. An Applied Research Program on Water Desalination with Renewable Energies

    Directory of Open Access Journals (Sweden)

    S. M. Alcocer


    Full Text Available The use of renewable energy for desalination might be quite different in many places of the world. In Mexico, specifically in Baja California, there is an abundance of “traditional” renewable resources like sun and wind but also some others like hot springs at the coast, tidal currents and tidal amplitudes of over six meters in the upper part of the Gulf of California associated with a severe scarcity of fresh water. The National University of Mexico (UNAM started two years ago a well organized research program to assess the amount of these resources and to find the way to use them for desalinating sea water. Very exiting results have being obtained: The abundance of hot springs at the shore, some of them over 84°C, lead to the design of thermal desalinating prototype plants with very little energy consumption. It was found by geochemistry that at a few meters deep, some 50 m, very high temperature can be obtained, easy to use in binary geothermal power plants to generate electricity for desalination. During the survey it was found that the amount of electrical power that can be generated with tidal storage and from deep sea hydrothermal vents is of the order of several thousands of MW. A special approach is also presented for the use of solar energy and the tidal currents of the Gulf. The IMPULSA research group at UNAM has been already consolidated with more than 30 students, dedicated to the design of appropriate equipment to make use of these resources and to characterize and quantify this huge amount of renewable energies that will permit to desalinate sea water.

  5. The epidemiology of malignant giant cell tumors of bone: an analysis of data from the Surveillance, Epidemiology and End Results Program (1975–2004

    Directory of Open Access Journals (Sweden)

    Kendra Schwartz


    Full Text Available Malignant giant cell tumor (GCT of bone is a rare tumor with debilitating consequences. Patients with GCT of bone typically present with mechanical difficulty and pain as a result of bone destruction and are at an increased risk for fracture. Because of its unusual occurrence, little is known about the epidemiology of malignant GCT of bone. This report offers the first reliable population-based estimates of incidence, patient demographics, treatment course and survival for malignancy in GCT of bone in the United States. Using data from the National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER program, we estimated the overall incidence and determinants of survival among patients diagnosed with malignant GCT of bone from 1975-2004. Cox proportional hazards regression was used to evaluate demographic and clinical determinants of survival among malignant GCT cases. Based on analyses of 117 malignant GCT cases, the estimated annual incidence in the United States was 1.6 per 10,000,000 persons per year. Incidence was highest among adults aged 20 to 44 years (2.4 per 10,000,000 per year and most patients were diagnosed with localized (31.6% or regional (29.9% disease compared to distant disease (16.2%. Approximately 85% of patients survived at least 5 years, with survival poorest among older patients and those with evidence of distant metastases at time of diagnosis. The current study represents the largest systematic investigation examining the occurrence and distribution of malignancy in GCT of bone in the general U.S. population. We confirm its rare occurrence and suggest that age and stage at diagnosis are strongly associated with long-term survival.

  6. Cancer Epidemiology Matters Blog (United States)

    The Cancer Epidemiology Matters blog helps foster a dialogue between the National Cancer Institute's (NCI) Epidemiology and Genomics Research Program (EGRP), extramural researchers, and other individuals, such as clinicians, community partners, and advocates, who are interested in cancer epidemiology and genomics.

  7. 34 CFR 650.3 - What regulations apply to the Jacob K. Javits Fellowship Program? (United States)


    ... Higher Education, Hospitals, and Nonprofit Organizations). (2) 34 CFR part 75 (Direct Grant Programs...); and (iii) Sections 75.580 through 75.592 of subpart E. (3) 34 CFR part 77 (Definitions that Apply...

  8. 42 CFR 4.1 - Programs to which these regulations apply. (United States)


    ... PROVISIONS NATIONAL LIBRARY OF MEDICINE § 4.1 Programs to which these regulations apply. (a) The regulations of this part govern access to the National Library of Medicine's facilities and library...

  9. 34 CFR 369.44 - What wage and hour standards apply to community rehabilitation programs? (United States)


    ... rehabilitation programs? 369.44 Section 369.44 Education Regulations of the Offices of the Department of... hour standards apply to community rehabilitation programs? All applicable Federal and State wage and hour standards must be observed in projects carried out in community rehabilitation...

  10. 34 CFR 642.4 - Regulations that apply to the Training Program. (United States)


    ... 34 Education 3 2010-07-01 2010-07-01 false Regulations that apply to the Training Program. 642.4 Section 642.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF...). (4) 34 CFR part 79 (Intergovernmental Review of Department of Education Programs and Activities)....

  11. 34 CFR 270.3 - What definitions apply to these programs? (United States)


    ... regulations for the Bilingual Education Program. (Authority: 20 U.S.C. 3223(a)(1)) National origin... 34 Education 1 2010-07-01 2010-07-01 false What definitions apply to these programs? 270.3 Section 270.3 Education Regulations of the Offices of the Department of Education OFFICE OF ELEMENTARY...

  12. Applying Coaching Strategies to Support Youth- and Family-Focused Extension Programming (United States)

    Olson, Jonathan R.; Hawkey, Kyle R.; Smith, Burgess; Perkins, Daniel F.; Borden, Lynne M.


    In this article, we describe how a peer-coaching model has been applied to support community-based Extension programming through the Children, Youth, and Families at Risk (CYFAR) initiative. We describe the general approaches to coaching that have been used to help with CYFAR program implementation, evaluation, and sustainability efforts; we…

  13. 34 CFR 363.53 - What special conditions apply to services and activities under this program? (United States)


    ... EDUCATION THE STATE SUPPORTED EMPLOYMENT SERVICES PROGRAM What Post-Award Conditions Must Be Met by a State... 34 Education 2 2010-07-01 2010-07-01 false What special conditions apply to services and activities under this program? 363.53 Section 363.53 Education Regulations of the Offices of the...

  14. 42 CFR 59a.11 - Programs to which these regulations apply. (United States)


    ... 42 Public Health 1 2010-10-01 2010-10-01 false Programs to which these regulations apply. 59a.11 Section 59a.11 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS NATIONAL LIBRARY OF MEDICINE GRANTS Establishment of Regional Medical Libraries § 59a.11 Programs to...

  15. 32 CFR Appendix A to Part 195 - Programs to Which This Part Applies (United States)


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Programs to Which This Part Applies A Appendix A...-EFFECTUATION OF TITLE VI OF THE CIVIL RIGHTS ACT OF 1964 Pt. 195, App. A Appendix A to Part 195—Programs to... consideration, or at a nominal or reduced consideration, on lands under the control of the Department of...

  16. 42 CFR 64.1 - Programs to which these regulations apply. (United States)


    ...) in library science and the field of communications of information pertaining to sciences relating to..., INTERNSHIPS, TRAINING NATIONAL LIBRARY OF MEDICINE TRAINING GRANTS § 64.1 Programs to which these regulations... apply to research training support under the National Research Service Awards Program (see part 66...

  17. Metropolitan Programs in Applied Biological and Agricultural Occupations; A Need and Attitude Study. Final Report. (United States)

    Thomas, Hollie B.; And Others

    To establish the feasibility of implementing applied biological and agricultural occupations programs in the metropolitan area of Chicago, four populations were surveyed by means of mailed questionnaires or interest inventories to determine: (1) the employment opportunities in the applied biological and agricultural industries, (2) the interests…

  18. Integrating Science in Applied Psychology Programs: A Student-Operated Journal (United States)

    Antonius, Daniel; Brown, Adam D.; Todman, McWelling; Safran, Jeremy D.


    As a requirement of APA accreditation, many PhD programs in applied psychology subscribe to some variant of the scientist-practitioner model. However, critics have argued that integrating science into an applied psychology curriculum may be too challenging a task. This article describes the development of The New School Psychology Bulletin, a…

  19. 34 CFR 655.4 - What definitions apply to the International Education Programs? (United States)


    ... private nonprofit agency, organization, or institution designated or created by a group of institutions of... 34 Education 3 2010-07-01 2010-07-01 false What definitions apply to the International Education...-GENERAL PROVISIONS General § 655.4 What definitions apply to the International Education Programs?...

  20. 34 CFR 400.1 - What is the purpose of the Vocational and Applied Technology Education Programs? (United States)


    ... Technology Education Programs? 400.1 Section 400.1 Education Regulations of the Offices of the Department of... APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.1 What is the purpose of the Vocational and Applied Technology Education Programs? (a) The purpose of the Vocational and Applied Technology...

  1. Estimation of Epidemiological Effectiveness of the Program of Pharmaceutical Prevention of Influenza and ARVI «Antigripp» in Organized Children's Groups

    Directory of Open Access Journals (Sweden)

    I. B. Yakovlev


    Full Text Available The authors estimated epidemiological effectiveness of the program for prophylaxis of influenza and ARVI «Antigripp» for children of 7—12 years old. Children received Arbidol (capsules of 100 mg 2 times a week for 3 weeks and Complivit activ. As a result there was a decline in absolute and relative indicators of ARVI morbidity risks. Epidemiological effectiveness of the program during the application of the drugs made up 56% and index of preventive efficacy was 2,3.

  2. 34 CFR 535.10 - How does an IHE apply to participate in the program? (United States)


    ... 34 Education 3 2010-07-01 2010-07-01 false How does an IHE apply to participate in the program? 535.10 Section 535.10 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF BILINGUAL EDUCATION AND MINORITY LANGUAGES AFFAIRS, DEPARTMENT OF EDUCATION BILINGUAL...

  3. 34 CFR 429.3 - What regulations apply to this program? (United States)


    ... 34 Education 3 2010-07-01 2010-07-01 false What regulations apply to this program? 429.3 Section 429.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION BILINGUAL VOCATIONAL MATERIALS, METHODS,...

  4. 34 CFR 429.2 - Who is eligible to apply for assistance under this program? (United States)


    ... 34 Education 3 2010-07-01 2010-07-01 false Who is eligible to apply for assistance under this program? 429.2 Section 429.2 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION BILINGUAL VOCATIONAL...

  5. 34 CFR 429.4 - What definitions apply to this program? (United States)


    ... 34 Education 3 2010-07-01 2010-07-01 false What definitions apply to this program? 429.4 Section 429.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION BILINGUAL VOCATIONAL MATERIALS, METHODS,...

  6. 28 CFR 90.101 - What definitions apply for the grant program? (United States)


    ... program? 90.101 Section 90.101 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) VIOLENCE AGAINST WOMEN Grants To Combat Violent Crimes Against Women on Campuses § 90.101 What definitions apply for the... violence laws of the jurisdiction, or by any other person against a victim who is protected from...

  7. Motives of Students' Joining Master Program at Princess Alia University College/Al Balqa Applied University (United States)

    Al Habahbeh, Abdullah Eid


    This study aimed at knowing the motives of students' joining master program at Princess Alia University College/Al Balqa Applied University by the graduate students and a degree of their importance and succession, and to know whether these motives differed according to the variables of gender, specialization, age, and marital status. To achieve…

  8. 34 CFR 460.3 - What regulations apply to the adult education programs? (United States)


    ... follows: (1) 34 CFR part 74 (Administration of Grants to Institutions of Higher Education, Hospitals, and Nonprofit Organizations). (2) 34 CFR part 75 (Direct Grant Programs) applies to parts 472, 473, 474, 475, 476, 477, 489, and 490, except that 34 CFR 75.720(b), regarding the frequency of certain reports,...

  9. 7 CFR 1783.2 - What Uniform Federal Assistance Provisions apply to the Revolving Fund Program? (United States)


    ... Administrative Requirements for Grants And Agreements with Institutions of Higher Education, Hospitals, and Other... FINANCING WATER AND WASTEWATER PROJECTS (REVOLVING FUND PROGRAM) General § 1783.2 What Uniform Federal... provisions that apply to all grants made by USDA and that are set forth in 7 CFR Part 3015—Uniform...

  10. 34 CFR 611.1 - What definitions apply to the Teacher Quality Enhancement Grants Program? (United States)


    ... elementary, middle, or secondary school operated by a high-need LEA in which the school's students or... 34 Education 3 2010-07-01 2010-07-01 false What definitions apply to the Teacher Quality Enhancement Grants Program? 611.1 Section 611.1 Education Regulations of the Offices of the Department...

  11. Epidemiologic survery of teniasis in health and family program in Uberaba, MG


    Flavia Maria Esteves; Mario León Silva-Vergara; Ângela C.F. Banzatto de Carvalho


    Foi realizado inquérito para avaliar alguns aspectos epidemiológicos da teníase em 100.144 indivíduos do Programa Saúde da Família. Foram identificados 185 (0,2%) indivíduos com antecedentes de teníase. Destes, 112 (60,5%) receberam tratamento com praziquantel. Em 97 (86,6%) dos casos, houve eliminação de proglotes que corresponderam a Taenia saginata e Taenia solium em 36 (37,1%) e 4 (4,1%), respectivamente.An epidemiologic survey was carried out on 110,144 people from the Health Family Prog...

  12. Radiation Leukemogenesis: Applying Basic Science of Epidemiological Estimates of Low Dose Risks and Dose-Rate Effects

    Energy Technology Data Exchange (ETDEWEB)

    Hoel, D. G.


    The next stage of work has been to examine more closely the A-bomb leukemia data which provides the underpinnings of the risk estimation of CML in the above mentioned manuscript. The paper by Hoel and Li (Health Physics 75:241-50) shows how the linear-quadratic model has basic non-linearities at the low dose region for the leukemias including CML. Pierce et. al., (Radiation Research 123:275-84) have developed distributions for the uncertainty in the estimated exposures of the A-bomb cohort. Kellerer, et. al., (Radiation and Environmental Biophysics 36:73-83) has further considered possible errors in the estimated neutron values and with changing RBE values with dose and has hypothesized that the tumor response due to gamma may not be linear. We have incorporated his neutron model and have constricted new A-bomb doses based on his model adjustments. The Hoel and Li dose response analysis has also been applied using the Kellerer neutron dose adjustments for the leukemias. Finally, both Pierce's dose uncertainties and Kellerer neutron adjustments are combined as well as the varying RBE with dose as suggested by Rossi and Zaider and used for leukemia dose-response analysis. First the results of Hoel and Li showing a significantly improved fit of the linear-quadratic dose response by the inclusion of a threshold (i.e. low-dose nonlinearity) persisted. This work has been complete for both solid tumor as well as leukemia for both mortality as well as incidence data. The results are given in the manuscript described below which has been submitted to Health Physics.

  13. 34 CFR 403.63 - How does a State carry out the State Vocational and Applied Technology Education Program? (United States)


    ... Applied Technology Education Program? 403.63 Section 403.63 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Kinds of Activities Does the Secretary Assist Under... Technology Education Program? (a) Unless otherwise indicated in the regulations in this part, a State...

  14. The Applied and Industrial Mathematics Program with Example Project: Efficient Routing for Meals on Wheels in the Shenandoah Valley (United States)

    Axvig, Nathan; David, John; Falcetti, Alex


    The Applied and Industrial Mathematics program partners applied mathematics students with businesses, governments, laboratories, and agencies to solve real problems. We will discuss the logistics of the program and give advice on starting and running similar programs. We also give a detailed example of a specific project, namely our work with the…

  15. Pack of Applied Programs for Complex Analysis of Thermo-Compressors

    Directory of Open Access Journals (Sweden)

    S. V. Zditovetskaya


    Full Text Available The paper proposes a pack of applied programs intended for conjugate calculation of cycle parameters with heat exchangers of thermo-compressor loop and a calculation of irreversible losses in the loop binding including non-stationary operational  mode is added to the pack.The paper contains investigations of thermo-compressor operation in the system of forced and exhaust ventilation for reduction of heat consumption by a heater in the cold season of the year

  16. Sharing NASA Science with Decision Makers: A Perspective from NASA's Applied Remote Sensing Training (ARSET) Program (United States)

    Prados, A. I.; Blevins, B.; Hook, E.


    NASA ARSET has been providing applied remote sensing training since 2008. The goals of the program are to develop the technical and analytical skills necessary to utilize NASA resources for decision-support. The program has reached over 3500 participants, with 1600 stakeholders from 100 countries in 2015 alone. The target audience for the program are professionals engaged in environmental management in the public and private sectors, such as air quality forecasters, public utilities, water managers and non-governmental organizations engaged in conservation. Many program participants have little or no expertise in NASA remote sensing, and it's frequently their very first exposure to NASA's vast resources. One the key challenges for the program has been the evolution and refinement of its approach to communicating NASA data access, research, and ultimately its value to stakeholders. We discuss ARSET's best practices for sharing NASA science, which include 1) training ARSET staff and other NASA scientists on methods for science communication, 2) communicating the proper amount of scientific information at a level that is commensurate with the technical skills of program participants, 3) communicating the benefit of NASA resources to stakeholders, and 4) getting to know the audience and tailoring the message so that science information is conveyed within the context of agencies' unique environmental challenges.

  17. The Applied Meteorology Unit: Nineteen Years Successfully Transitioning Research Into Operations for America's Space Program (United States)

    Madura, John T.; Bauman, William H., III; Merceret, Francis J.; Roeder, William P.; Brody, Frank C.; Hagemeyer, Bartlett C.


    The Applied Meteorology Unit (AMU) provides technology development and transition services to improve operational weather support to America's space program . The AMU was founded in 1991 and operates under a triagency Memorandum of Understanding (MOU) between the National Aeronautics and Space Administration (NASA), the United States Air Force (USAF) and the National Weather Service (NWS) (Ernst and Merceret, 1995). It is colocated with the 45th Weather Squadron (45WS) at Cape Canaveral Air Force Station (CCAFS) and funded by the Space Shuttle Program . Its primary customers are the 45WS, the Spaceflight Meteorology Group (SMG) operated for NASA by the NWS at the Johnson Space Center (JSC) in Houston, TX, and the NWS forecast office in Melbourne, FL (MLB). The gap between research and operations is well known. All too frequently, the process of transitioning research to operations fails for various reasons. The mission of the AMU is in essence to bridge this gap for America's space program.

  18. Inside the "Black Box" of a Knowledge Translation Program in Applied Health Research. (United States)

    Heaton, Janet; Day, Jo; Britten, Nicky


    In this article, we present the findings of a participatory realistic evaluation of a 5-year program of health care research intended to promote the translation of knowledge into routine clinical practice. The program was one of the nine pilot Collaborations for Leadership in Applied Health Research and Care funded by the English National Institute for Health Research between 2008 and 2013. Our aim was to delineate the mechanisms by which, and circumstances in which, some projects carried out under the program achieved success in knowledge translation while others were frustrated. Using qualitative methods, we examined how closer collaboration between academics and clinicians worked in four purposefully chosen case studies. In a synthesis of the findings, we produced a "black box" model of how knowledge translation was enabled by the activation of nine mechanisms. These are summarized in the form of five simple rules for promoting knowledge translation through collaborations based on principles of coproduction.

  19. Evaluation model applied to TRANSPETRO's Marine Terminals Standardization Program

    Energy Technology Data Exchange (ETDEWEB)

    Almeida, Maria Fatima Ludovico de; Mueller, Gabriela [Pontificia Universidade Catolica do Rio de Janeiro (PUC-Rio), Rio de Janeiro, RJ (Brazil). Instituto Tecnologico; Garcia, Luciano Maldonado [TRANSPETRO - PETROBRAS Transporte S.A., Rio de Janeiro, RJ (Brazil)


    This paper describes an innovative evaluation model applied to TRANSPETRO's 'Marine Terminals Standardization Program' based on updating approaches of programs evaluation and organizational learning. Since the program was launched in 2004, the need for having an evaluation model able to evaluate its implementation progress, to measure the degree of standards compliance and its potential economic, social and environmental impacts has become evident. Within a vision of safe and environmentally responsible operations of marine terminals, this evaluation model was jointly designed by TRANSPETRO and PUC-Rio to promote continuous improvement and learning in operational practices and in the standardization process itself. TRANSPETRO believes that standardization supports its services and management innovation capability by creating objective and internationally recognized parameters, targets and metrology for its business activities. The conceptual model and application guidelines for this important tool are presented in this paper, as well as the next steps towards its implementation. (author)

  20. Program Applied Biology and Biotechnology. Annual report 1987. Programm Angewandte Biologie und Biotechnologie. Jahresbericht 1987

    Energy Technology Data Exchange (ETDEWEB)


    By order of the Federal Government, the Biology, Ecology, Energy Department (PBE) is responsible for the 3 sub-programs 'energy research and technologies', 'applied biology and biotechnology' and 'environmental research and technology'. This volume deals with the second-mentioned sub-program and briefly describes the projects supported by the Federal Government, specifically the objectives, working program, state of the studies, costs and share in the costs paid by the Federal Government. The following subdivision was made: 1. biological process engineering and enzyme technology, 2. cell culture and cell fusion technology, 3. genetic engineering and microbial technologies, 4. equivalent methods which can replace animal experiments, biological security, 5. plant genetics and protection, 6. promotion of focal points of activity, 7. indirect specific promotion, 8. new fields and overlapping activities in biotechnology, 9. regrowing raw materials. (RB).

  1. Epidemiology chapter. (United States)

    Wolfram, J H; Butaev, M K; Duysheev, A; Gabbasova, A R; Khasanov, O S; Kulakov, Yu K; Mkrtchyan, A R; Myrzabekov, A M; Nurgaziev, R Z; Tsirel'son, L E; Willer, R D; Yaraev, R G; Zheludkov, M M


    This chapter outlines the epidemiology of brucellosis in the Russian Federation and in five countries bordering Russia. Since the Soviet Union's dissolution, Russia and the newly formed independent republics have failed to maintain policies to control brucellosis and other zoonotic diseases. Many of these republics, due to weak animal control and prevention systems and dangerous food preparation practices, are still burdened with the human cost of brucellosis. The final summary of this section provides an example of the successful transboundary cooperative efforts between Arizona and Mexico, which could be applied to the situation between Russia and the bordering independent republics.

  2. Should Osteopathic Students Applying to Allopathic Emergency Medicine Programs Take the USMLE Exam?

    Directory of Open Access Journals (Sweden)

    Moshe Weizberg


    Full Text Available Introduction: Board scores are an important aspect of an emergency medicine (EM residency application. Residency directors use these standardized tests to objectively evaluate an applicant’s potential and help decide whether to interview a candidate. While allopathic (MD students take the United States Medical Licensing Examination (USMLE, osteopathic (DO students take the Comprehensive Osteopathic Medical Licensing Examination (COMLEX. It is difficult to compare these scores. Previous literature proposed an equation to predict USMLE based on COMLEX. Recent analyses suggested this may no longer be accurate. DO students applying to allopathic programs frequently ask whether they should take USMLE to overcome this potential disadvantage. The objective of the study is to compare the likelihood to match of DO applicants who reported USMLE to those who did not, and to clarify how important program directors consider it is whether or not an osteopathic applicant reported a USMLE score. Methods: We conducted a review of Electronic Residency Application Service (ERAS and National Resident Matching Program (NRMP data for 2010-2011 in conjunction with a survey of EM residency programs. We reviewed the number of allopathic and osteopathic applicants, the number of osteopathic applicants who reported a USMLE score, and the percentage of successful match. We compared the percentage of osteopathic applicants who reported a USMLE score who matched compared to those who did not report USMLE. We also surveyed allopathic EM residency programs to understand how important it is that osteopathic (DO students take USMLE. Results: There were 1,482 MD students ranked EM programs; 1,277 (86%, 95% CI 84.3-87.9 matched. There were 350 DO students ranked EM programs; 181 (52%, 95% CI 46.4-57.0 matched (difference=34%, 95% CI 29.8-39.0, p<0.0001. There were 208 DO students reported USMLE; 126 (61%, 95% CI 53.6-67.2 matched. 142 did not report USMLE; 55 (39%, 95% CI 30

  3. 34 CFR 661.2 - Who is eligible to apply for a grant under the Business and International Education Program? (United States)


    ... INTERNATIONAL EDUCATION PROGRAM General § 661.2 Who is eligible to apply for a grant under the Business and... 34 Education 3 2010-07-01 2010-07-01 false Who is eligible to apply for a grant under the Business and International Education Program? 661.2 Section 661.2 Education Regulations of the Offices of...

  4. Waste tank safety program annual status report for FY 1993, Task 5: Toxicology and epidemiology

    Energy Technology Data Exchange (ETDEWEB)

    Mahlum, D.D.; Young, J.Y.


    A toxicology team independently reviewed analytical data and provided advice concerning potential health effects associated with exposure to tank-vapor constituents at the Hanford site. Most of the emphasis was directed toward Tank 241-C-103, but a preliminary assessment was also made of the toxicologic implication of the cyanide levels in the headspace of Tank 241-C-108. The objectives of this program are to (1) review procedures used for sampling vapors from various tanks, (2) identify constituents in tank-vapor samples that could be related to symptoms reported by waste-tank workers, (3) evaluate the toxicologic implications of those constituents by comparison to established toxicologic data bases, (4) provide advice for additional analytical efforts, and (5) support other activities as requested by the project manager and the cognizant Westinghouse Hanford Company Tank Vapor Issues Safety Resolution Manager.

  5. NASA Applied Sciences' DEVELOP Program Fosters the Next Generation of Earth Remote Sensing Scientists (United States)

    Childs, Lauren M.; Brozen, Madeline W.; Gleason, Jonathan L.; Silcox, Tracey L.; Rea, Mimi; Holley, Sharon D.; Renneboog, Nathan; Underwood, Lauren W.; Ross, Kenton W.


    Satellite remote sensing technology and the science associated with the evaluation of the resulting data are constantly evolving. To meet the growing needs related to this industry, a team of personnel that understands the fundamental science as well as the scientific applications related to remote sensing is essential. Therefore, the workforce that will excel in this field requires individuals who not only have a strong academic background, but who also have practical hands-on experience with remotely sensed data, and have developed knowledge of its real-world applications. NASA's DEVELOP Program has played an integral role in fulfilling this need. DEVELOP is a NASA Science Mission Directorate Applied Sciences training and development program that extends the benefits of NASA Earth science research and technology to society.

  6. Selections of reality: applying Burke's dramatism to a harm reduction program. (United States)

    Järvinen, Margaretha; Miller, Gale


    Kenneth Burke's dramatistic perspective is applied to accounts told by staff members working in methadone maintenance treatment centres in Copenhagen, Denmark. As a harm reduction strategy, methadone maintenance is designed to reduce the costs and dangers of chronic long-term drug use by providing substitution (methadone) treatment to users. Burke's dramatistic perspective calls attention to the recurring relationships among rhetorical elements within accounts of social reality. The elements form a pentad: scene, purpose, agent, agency and acts. Our analysis examines how the ideal of governmentality is constructed by staff members to justify and criticize the operations of the Copenhagen methadone maintenance program. For Burke, social criticism involves rearranging pentadic elements to produce new meanings and justify alternative actions. We discuss how Burke's perspective might be developed by sociologists as a critical dramatism of social policies and programs.

  7. Brucellosis Prevention Program: Applying “Child to Family Health Education” Method

    Directory of Open Access Journals (Sweden)

    H. Allahverdipour


    Full Text Available Introduction & Objective: Pupils have efficient potential to increase community awareness and promoting community health through participating in the health education programs. Child to family health education program is one of the communicative strategies that was applied in this field trial study. Because of high prevalence of Brucellosis in Hamadan province, Iran, the aim of this study was promoting families’ knowledge and preventive behaviors about Brucellosis in the rural areas by using child to family health education method.Materials & Methods: In this nonequivalent control group design study three rural schools were chosen (one as intervention and two others as control. At first knowledge and behavior of families about Brucellosis were determined using a designed questionnaire. Then the families were educated through “child to family” procedure. At this stage the students gained information. Then they were instructed to teach their parents what they had learned. After 3 months following the last session of education, the level of knowledge and behavior changes of the families about Brucellosis were determined and analyzed by paired t-test.Results: The results showed significant improvement in the knowledge of the mothers. The knowledge of the mothers about the signs of Brucellosis disease in human increased from 1.81 to 3.79 ( t:-21.64 , sig:0.000 , and also the knowledge on the signs of Brucellosis in animals increased from 1.48 to 2.82 ( t:-10.60 , sig:0.000. Conclusion: Child to family health education program is one of the effective and available methods, which would be useful and effective in most communities, and also Students potential would be effective for applying in the health promotion programs.

  8. Summary and abstracts: Applied Research Units and Projects 1996 UCETF Program

    Energy Technology Data Exchange (ETDEWEB)



    The Urban Consortium (UC), created by PTI, is a network of jurisdictions with populations of over 250,000. The UC provides a platform for research and enterprise through its Energy, Environmental, Transportation, and Telecommunications and Information Task Forces. The UC provides a unique creative forum where elected and appointed officials and technical managers identify, test, and validate practical ways to improve the provision of public services and, where possible, generate new revenue opportunities. Public Technology, Inc., is the non-profit technology organization of the National League of Cities, the National Association of Counties, and the International City/County Management Association. PTI creates and advances technology-based products, services, and enterprises in cities and counties nationwide. Staffed by PTI, the UC addresses the critical needs of local governments through its Task Forces. The Urban Consortium Energy Task Force (UCETF) program has, since its inception, acted as a laboratory to develop, test solutions and share the resulting products or management approaches with the wider audience of local governments. It has addressed the overlap between energy and environment and economic development policy issues, and, is the nation's most extensive cooperative local government program to improve energy management and decision-making through applied research and technology cooperation. Proposals to meet the specific objectives of the UCETF annual R and D program are solicited from major urban jurisdictions. Projects based on these proposals are then selected by the UCETF for direct conduct and management by staff of city and county governments. Projects selected for each year's program are organized in thematic units to assure effective management and ongoing peer-to-peer experience exchange, with results documented at the end of each program year.

  9. Towson University's Professional Science Master's Program in Applied Physics: The first 5 years (United States)

    Kolagani, Rajeswari

    It is a well-established fact that the scientific knowledge and skills acquired in the process of obtaining a degree in physics meet the needs of a variety of positions in multiple science and technology sectors. However, in addition to scientific competence, challenging careers often call for skills in advanced communication, leadership and team functions. The professional science master's degree, which has been nick-named as the `Science MBA', aims at providing science graduates an edge both in terms of employability and earning levels by imparting such skills. Our Professional Science Master's Program in Applied Physics is designed to develop these `plus' skills through multiple avenues. In addition to advanced courses in Applied Physics, the curriculum includes graduate courses in project management, business and technical writing, together with research and internship components. I will discuss our experience and lessons learned over the 5 years since the inception of the program in 2010. The author acknowledges support from the Elkins Professorship of the University System of Maryland.

  10. [Epidemiologic approaches, in school health education programs with particular attention to dentistry]. (United States)

    Percoco, M; Fasiolo, P; Antonelli, A; Simonetti D'Arca, A


    At the request of the Cultural Union of the Upper Aniene Valley, the social-health workers dealing with school medicine of the Teaching District of Affile (Rome) have tried to define the programming lines for a health education intervention in the elementary schools of the district. The basic requisites of the intervention were pinpointed as: effectiveness, in terms of improvement of health conditions; short-term results; cognitive-transformative methodology having a spiral progression (cognitive, decision-making, implementative and of verification). The departure point of the intervention was the cognitive study on the social-health situation of the school population based on an analysis of the individual data contained in the medical files compiled by the school doctor, standardised and filled out with the pupils' social and family data. Out of 257 children, 212 were examined, namely 82.4% of the school population. The first social-anamnestic data on pupils' families was in respect of parents' level of education, giving the following results: 65% with elementary schooling only, 11% semi-illiterate and 10.5% diploma- or degree-holders. In respect of parents' working activities, on the other hand, a clear difference emerged: compared with 50.4% of worker or artisan fathers and about 33.3% engaged in the tertiary sector, almost all the mothers were still home-based (90.9% housewives). Another interesting fact emerged from the cards, namely that only 69% of the boys and girls have undergone the full cycle of antidiphtheria-antitetanus vaccinations, and only 80% of antipolio vaccinations. As regards pupils pathological anamnesis, cases of hospitalisation were for the following causes: 5.7% fractures and/or burns, followed by intestinal infections (4.5%). Whereas, as regards current pathology the high incidence of a cariogenic pathology emerged, with such high values as to indicate, in the field of prevention and health education, oral hygiene as the priority

  11. Positive impact of a master of science in applied anatomy program on USMLE Step 1 performance. (United States)

    Fredieu, John R; Snyder, Clint W


    In this retrospective study of medical student data from Case Western Reserve University School of Medicine, we examined the impact of the Master of Science in Applied Anatomy (MS) program on medical student performance on the United States Medical Licensing Examination(®) (USMLE(®)) Step 1 and Step 2. From 2002 to 2010, 1,142 students matriculated as either students in the medical curriculum (MD group; 1,087 students) or MD students who also participated in the MS program (MD/MS group; 55 students). In addition, students were grouped as in either the Western Reserve Curriculum (2002-2005; WR1) or the Western Reserve 2 Curriculum (2006-2010; WR2). Data were analyzed using SPSS statistical package. The mean Medical College Admission Test(®) (MCAT(®)) score of all students increased significantly between the WR1 and WR2 curricula [from 32.48 ± 3.73 to 34.00 ± 2.92 (P USMLE Step 1 score for the MD/MS group (241.45 ± 18.90) was significantly higher than that of the MD group (229.93 ± 20.65; P USMLE Step 1 scores than the MD group. No significant difference was observed in the USMLE Step 2 Clinical Knowledge scores between the groups. The results show that MD/MS students performed better on the USMLE Step 1 than MD students in the WR2 curriculum, although MCAT scores were similar between the two groups. Together, these results suggest that medical student participation in the Masters in Applied Anatomy program enhances student performance on the USMLE Step 1.

  12. Summary of the Nevada Applied Ecology Group and correlative programs. Version 1

    Energy Technology Data Exchange (ETDEWEB)

    Friesen, H.N. [Raytheon Services Nevada, Las Vegas, NV (United States)


    This summary document presents results in a broad context; it is not limited to findings of the Nevada Applied Ecology Group. This book is organized to present the findings of the Nevada Applied Ecology Group and correlative programs in accordance with the originally stated objectives of the Nevada Applied Ecology Group. This plan, in essence, traces plutonium from its injection into the environment to movement in the ecosystem to development of cleanup techniques. Information on other radionuclides was also obtained and will be presented briefly. Chapter 1 presents a brief description of the ecological setting of the Test Range Complex. The results of investigations for plutonium distribution are presented in Chapter 2 for the area surrounding the Test Range Complex and in Chapter 3 for on-site locations. Chapters 4 and 5 present the results of investigations concerned with concentrations and movement, respectively, of plutonium in the ecosystem of the Test Range Complex, and Chapter 6 summarizes the potential hazard from this plutonium. Development of techniques for cleanup and treatment is presented in Chapter 7, and the inventory of radionuclides other than plutonium is presented briefly in Chapter 8.

  13. Disease surveillance system evaluation as a model for improved integration and standardization of the laboratory component in the Field Epidemiology and Laboratory Training Program (FELTP) curriculum worldwide. (United States)

    Rush, Thomas


    Integration of laboratory training into the Centers for Disease Control and Prevention's (CDC) Field Epidemiology Training Program (FETP) began in 2004 and has advanced the training of laboratory scientists worldwide on the basic principles of epidemiology, disease surveillance, and outbreak investigation. The laboratory component of the FE(L)TP training has traditionally been disease specific, revolving around classroom and bench training on laboratory methods, and field placement in areas where services are needed. There is however a need to improve the integration of epidemiology elements used in surveillance, outbreak investigation, and evaluation activities with specific measurable laboratory activities that could in turn impact the overall disease surveillance and response. A systematic and clear evaluation guideline for the laboratory components of disease surveillance systems alongside the corresponding epidemiological indicators can better identify, address, and mitigate weaknesses that may exist in the entire surveillance system, and also help to integrate and standardize the FE(L)TP curriculum content. The institution of laboratory Quality Management System principles linked to a comprehensive surveillance evaluation scheme will result in improved disease surveillance, response, and overall laboratory capacity over time.

  14. Epidemiological and Clinical Study of Phenylketonuria (PKU Disease in the National Screening Program of Neonates, Fars Province, Southern Iran

    Directory of Open Access Journals (Sweden)

    S Senemar


    Full Text Available "nBackground: Classic phenylketonuria (PKU is a rare metabolic disorder that results from a deficiency of a liver enzyme known as phenylalanine hydroxylase (PAH. In this study, we researched about PKU epidemiological factors and health quality of patients after the neonatal screening program."nMethods: Neonatal screening for PKU was conducted by one neonatal screening center in Fars Province, in Shiraz Paramedical University. All Fars infants must refer only to this center, in which a heel prick blood sample  of each infant was collected at 72 hours postnatal on to standard filter paper and asked questions from the children's parent's and the doctor examined the patients receiving phenylalanine- free milk through examining the children's development. PKU was screened by Fluorometric method."nResults: Totally of 70477 newborns screened for PKU, 15- cases of PKU detected with an incidence of 1:4698. In "Eghlid", that is a city in Fars Province. The prevalence of the disease is 1:382 of newly born babies. The frequency of familial marriage in these children's parents is 86.6%. Twenty nine percent of them were observed among those who had married their close relatives. Mean rate of normal development in PKU patients was 95%."nConclusion: Consanguineous marriage is a major cause in that pattern particular in Iranian. The treatment of PKU after newborn screening is used. With special diet in above of 90% newborn is satisfactory. Now screening should be executed for all of family that they have familial history of PKU in Iran.

  15. Stochastic Dynamic Programming Applied to Hydrothermal Power Systems Operation Planning Based on the Convex Hull Algorithm

    Directory of Open Access Journals (Sweden)

    Bruno H. Dias


    Full Text Available This paper presents a new approach for the expected cost-to-go functions modeling used in the stochastic dynamic programming (SDP algorithm. The SDP technique is applied to the long-term operation planning of electrical power systems. Using state space discretization, the Convex Hull algorithm is used for constructing a series of hyperplanes that composes a convex set. These planes represent a piecewise linear approximation for the expected cost-to-go functions. The mean operational costs for using the proposed methodology were compared with those from the deterministic dual dynamic problem in a case study, considering a single inflow scenario. This sensitivity analysis shows the convergence of both methods and is used to determine the minimum discretization level. Additionally, the applicability of the proposed methodology for two hydroplants in a cascade is demonstrated. With proper adaptations, this work can be extended to a complete hydrothermal system.

  16. Applying Monte Carlo Concept and Linear Programming in Modern Portfolio Theory to Obtain Best Weighting Structure

    Directory of Open Access Journals (Sweden)

    Tumpal Sihombing


    Full Text Available The world is entering the era of recession when the trend is bearish and market is not so favorable. The capital markets in every major country were experiencing great amount of loss and people suffered in their investment. The Jakarta Composite Index (JCI has shown a great downturn for the past one year but the trend bearish year of the JCI. Therefore, rational investors should consider restructuring their portfolio to set bigger proportion in bonds and cash instead of stocks. Investors can apply modern portfolio theory by Harry Markowitz to find the optimum asset allocation for their portfolio. Higher return is always associated with higher risk. This study shows investors how to find out the lowest risk of a portfolio investment by providing them with several structures of portfolio weighting. By this way, investor can compare and make the decision based on risk-return consideration and opportunity cost as well. Keywords: Modern portfolio theory, Monte Carlo, linear programming

  17. Positive Mathematical Programming Approaches – Recent Developments in Literature and Applied Modelling

    Directory of Open Access Journals (Sweden)

    Thomas Heckelei


    Full Text Available This paper reviews and discusses the more recent literature and application of Positive Mathematical Programming in the context of agricultural supply models. Specifically, advances in the empirical foundation of parameter specifications as well as the economic rationalisation of PMP models – both criticized in earlier reviews – are investigated. Moreover, the paper provides an overview on a larger set of models with regular/repeated policy application that apply variants of PMP. Results show that most applications today avoid arbitrary parameter specifications and rely on exogenous information on supply responses to calibrate model parameters. However, only few approaches use multiple observations to estimate parameters, which is likely due to the still considerable technical challenges associated with it. Equally, we found only limited reflection on the behavioral or technological assumptions that could rationalise the PMP model structure while still keeping the model’s advantages.

  18. Development of Education Program Applying Internal Combustion Engine with Bioethanol as Fuel (United States)

    Utsumi, Noah; Yoshida, Masashi; Inada, Yuji

    One of the ways to mitigate global warming is to reduce carbon dioxide emissions. In Japan, carbon dioxide emissions from vehicles, which run on fossil fuels, account for about 1/4 of the total carbon dioxide emissions. In this study, we applied a commercial engine, and remodeled the engine which could work using bioethanol as a fuel. We subsequently examined the influence of exhaust emission of the engine with the bioethanol and documented the entire study as teaching materials, including the remodeling method. Next, we began our mechanical engineering courses at the university by using the teaching materials in this study as introductory education, with the aim of stimulating the interest of the students. We then developed an education program for the students.

  19. 20 CFR 669.170 - What WIA regulations apply to the programs funded under WIA section 167? (United States)


    ... nonprofit organizations at 29 CFR parts 95, 96, 97, and 99, as applicable. (d) The regulations on... ACT Purpose and Definitions § 669.170 What WIA regulations apply to the programs funded under...

  20. 78 FR 55084 - Proposed Collection; 60-day Comment Request; Data Collection To Understand How NIH Programs Apply... (United States)


    ..., change management, organizational assessment and intervention, organizational design, process improvement... are employed to increase organizational effectiveness. The Office of Management and Budget (OMB) and... effectively is to understand how NIH research programs apply methodologies to improve their...

  1. NASA Applied Sciences' DEVELOP National Program: a unique model cultivating capacity in the geosciences (United States)

    Ross, K. W.; Favors, J. E.; Childs-Gleason, L. M.; Ruiz, M. L.; Rogers, L.; Allsbrook, K. N.


    The NASA DEVELOP National Program takes a unique approach to cultivating the next generation of geoscientists through interdisciplinary research projects that address environmental and public policy issues through the application of NASA Earth observations. Competitively selected teams of students, recent graduates, and early career professionals take ownership of project proposals outlining basic application concepts and have ten weeks to research core scientific challenges, engage partners and end-users, demonstrate prototypical solutions, and finalize and document their results and outcomes. In this high pressure, results-driven environment emerging geoscience professionals build strong networks, hone effective communication skills, and learn how to call on the varied strengths of a multidisciplinary team to achieve difficult objectives. The DEVELOP approach to workforce development has a variety of advantages over classic apprenticeship-style internship systems. Foremost is the experiential learning of grappling with real-world applied science challenges as a primary actor instead of as an observer or minor player. DEVELOP participants gain experience that fosters personal strengths and service to others, promoting a balance of leadership and teamwork in order to successfully address community needs. The program also advances understanding of Earth science data and technology amongst participants and partner organizations to cultivate skills in managing schedules, risks and resources to best optimize outcomes. Individuals who come through the program gain experience and networking opportunities working within NASA and partner organizations that other internship and academic activities cannot replicate providing not only skill development but an introduction to future STEM-related career paths. With the competitive nature and growing societal role of science and technology in today's global community, DEVELOP fosters collaboration and advances environmental

  2. 34 CFR 79.6 - What procedures apply to the selection of programs and activities under these regulations? (United States)


    ... 34 Education 1 2010-07-01 2010-07-01 false What procedures apply to the selection of programs and activities under these regulations? 79.6 Section 79.6 Education Office of the Secretary, Department of Education INTERGOVERNMENTAL REVIEW OF DEPARTMENT OF EDUCATION PROGRAMS AND ACTIVITIES § 79.6 What...

  3. 76 FR 78095 - Applying for Free and Reduced Price Meals in the National School Lunch Program and School... (United States)


    ...: Julie Brewer, Chief, Policy and Program Development Branch, Child Nutrition Division, Food and Nutrition... Food and Nutrition Service 7 CFR Parts 210, 215, 220, 235 and 245 RIN 0584-AD54 Applying for Free and... the Special Milk Program, and Technical Amendments AGENCY: Food and Nutrition Service, USDA....

  4. 45 CFR 309.170 - What statistical and narrative reporting requirements apply to Tribal IV-D programs? (United States)


    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What statistical and narrative reporting... (IV-D) PROGRAM Statistical and Narrative Reporting Requirements § 309.170 What statistical and narrative reporting requirements apply to Tribal IV-D programs? (a) Tribes and Tribal...

  5. 20 CFR 645.260 - What health and safety provisions apply to participants in Welfare-to-Work programs? (United States)


    ... participants in Welfare-to-Work programs? 645.260 Section 645.260 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR PROVISIONS GOVERNING WELFARE-TO-WORK GRANTS General Program and Administrative Requirements § 645.260 What health and safety provisions apply to participants in...

  6. Identification of the Competencies Needed to Apply Social Marketing to Extension Programming: Results of a Delphi Study (United States)

    Warner, Laura A.; Stubbs, Eric; Murphrey, Theresa Pesl; Huynh, Phuong


    The purpose of this study was to identify the specific competencies needed to apply social marketing, a promising approach to behavior change, to Extension programming. A modified Delphi study was used to achieve group consensus among a panel of experts on the skills, characteristics, and knowledge needed to successfully apply this behavior change…

  7. The Master of Science in clinical epidemiology degree program of the Perelman School of Medicine at the University of Pennsylvania: a model for clinical research training. (United States)

    Strom, Brian L; Kelly, Thomas O; Norman, Sandra A; Farrar, John T; Kimmel, Stephen E; Lautenbach, Ebbing; Feldman, Harold I


    An innovative training program to provide clinical research training for clinicians was created in 1979 at the University of Pennsylvania School of Medicine, now the Perelman School of Medicine. The program's principal and continuing aim is to provide trainees mentored experiences and the training needed to become skilled independent investigators able to conduct clinical research and develop academic careers as independent clinical investigators.The authors identify the vision that led to the creation of the master of science in clinical epidemiology (MSCE) degree program and describe today's training program, including administration, oversight, participating faculty, and trainees. They also describe the program's core curriculum, elective options, seminars on ongoing research, training in the responsible conduct of research, professional development activities, and the development and completion of a closely mentored clinical research project.Approximately 35 new trainees enter the two- to three-year program annually. Funding is provided primarily by National Institutes of Health-funded training programs and supplemented by private industry, private foundations, and employee-based benefits. More than 500 individuals have received or are currently receiving training through the MSCE program. A large percentage of former trainees maintain full-time positions in academic medicine today.The authors identify some challenges that have been met and insights regarding funding, faculty, trainees, and curriculum. Ongoing challenges include recruiting trainees from some selected highly paid, procedure-oriented specialties, maintaining sufficient mentors for the continually increasing numbers of trainees, and distinguishing applicants who truly desire a primary research career from others.

  8. Energy Programs at the Johns Hopkins University Applied Physics Laboratory, Quarterly Report, October-December 1980

    Energy Technology Data Exchange (ETDEWEB)



    The Johns Hopkins University Applied Physics Laboratory is engaged in developing energy resources, utilization concepts, and monitoring and storage methods. This Quarterly Report summarizes the work on the various tasks as of 31 December 1980. The Energy Quarterly Report is divided into five sections. The first, Geothermal Energy Development Planning and Technical Assistance, supported by the Department of Energy/Division of Geothermal Energy (DOE/DGE), contains reports on the progress of geothermal-related tasks on which effort was concentrated during the quarter. The second section, Operational Research, Hydroelectric Power Development, supported by the Department of Energy/Resource Applications (DOE/RA), contains a report on institutional problems for small-scale hydroelectric power development in the southeastern states and a list of documents published by APL in the hydroelectric program and in the geothermal program, above. The third section, Seismotectonic Investigations, contains an article on work on the geologic structure of the Danbury Quadrangle that is supported by the Reactor Safety Research Division of the Nuclear Regulatory Commission (NRC) and an in-house supported study on a new method for assessing earthquakes in intraplate regions. The fourth section, Energy Conversion and Storage Techniques, contains four articles. The first is an evaluation of the Einstein refrigerator, supported by independent IR and D funds. The second concerns fly-wheel technology development at APL supported by the Department of Energy, Division of Energy Storage (DOE/STOR). The third is a report on APL energy conservation efforts at its own buildings, and the fourth is an article on liquefied natural gas (LNG) safety evaluation, supported by the National Academy of Sciences. The fifth section explores the value of establishing an Energy Research Institute at The Johns Hopkins University.

  9. Applying Best Practices to Florida Local Government Retrofit Programs, Central Florida (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)


    In some communities, local government and non-profit entities have funds to purchase and renovate distressed, foreclosed homes for resale in the affordable housing market. Numerous opportunities to improve whole house energy efficiency are inherent in these comprehensive renovations. BA-PIRC worked together in a multi-year field study making recommendations in individual homes, meanwhile compiling improvement costs, projected energy savings, practical challenges, and labor force factors surrounding common energy-related renovation measures. The field study, Phase 1 of this research, resulted in a set of best practices appropriate to the current labor pool and market conditions in central Florida to achieve projected annual energy savings of 15-30% and higher. This report describes Phase 2 of the work where researchers worked with a local government partner to implement and refine the "current best practices". A simulation study was conducted to characterize savings potential under three sets of conditions representing varying replacement needs for energy-related equipment and envelope components. The three scenarios apply readily to the general remodeling industry as for renovation of foreclosed homes for the affordable housing market. Our new local government partner, the City of Melbourne, implemented the best practices in a community-scale renovation program that included ten homes in 2012. ​

  10. Fusion programs in applied plasma physics. Final report, fiscal years 1989--1991

    Energy Technology Data Exchange (ETDEWEB)


    The objectives of the theoretical science program are: To support the interpretation of present experiments and predict the outcome of future planned experiments; to improve on existing models and codes and validate against experimental results; and to conduct theoretical physics development of advanced concepts with applications for DIII-D and future devices. Major accomplishments in FY91 include the corroboration between theory and experiment on MHD behavior in the second stable regime of operation on DIII-D, and the frequency and mode structure of toroidal Alfven eigenmodes in high beta, shaped plasmas. We have made significant advances in the development of the gyro-Landau fluid approach to turbulence simulation which more accurately models kinetic drive and damping mechanisms. Several theoretical models to explain the bifurcation phenomenon in L- to H-mode transition were proposed providing the theoretical basis for future experimental verification. The capabilities of new rf codes have been upgraded in response to the expanding needs of the rf experiments. Codes are being employed to plan for a fully non-inductive current drive experiment in a high beta, enhanced confinement regime. GA`s experimental effort in Applied Physics encompasses two advanced diagnostics essential for the operation of future fusion experiments: Alpha particle diagnostic, and current and density profile diagnostics. This paper discusses research in all these topics.

  11. CEDR: Comprehensive Epidemiologic Data Resource

    Energy Technology Data Exchange (ETDEWEB)


    The Department of Energy (DOE) and its predecessor agencies have a long history of epidemiologic research programs. The main focus of these programs has been the Health and Mortality Study of the DOE work force. This epidemiologic study began in 1964 with a feasibility study of workers at the Hanford facility. Studies of other populations exposed to radiation have also been supported, including the classic epidemiologic study of radium dial painters and studies of atomic bomb survivors. From a scientific perspective, these epidemiologic research program have been productive, highly credible, and formed the bases for many radiological protection standards. Recently, there has been concern that, although research results were available, the data on which these results were based were not easily obtained by interested investigators outside DOE. Therefore, as part of an effort to integrate and broaden access to its epidemiologic information, the DOE has developed the Comprehensive Epidemiologic Data Resource (CEDR) Program. Included in this effort is the development of a computer information system for accessing the collection of CEDR data and its related descriptive information. The epidemiologic data currently available through the CEDAR Program consist of analytic data sets, working data sets, and their associated documentation files. In general, data sets are the result of epidemiologic studies that have been conducted on various groups of workers at different DOE facilities during the past 30 years.

  12. Recent Weather Technologies Delivered to America's Space Program by the Applied Meteorology Unit (United States)

    Bauman, WIlliam, H., III; Crawford, Winifred


    The Applied Meteorology Unit (AMU) is a unique joint venture of NASA, the Air Force and the National Weather Service (NWS) and has been supporting the Space Program for nearly two decades. The AMU acts as a bridge between the meteorological research community and operational forecasters by developing, evaluating and transitioning new technology and techniques to improve weather support to spaceport operations at the Eastern Range (ER) and Kennedy Space Center. Its primary customers are the 45th Weather Squadron at Cape Canaveral Air Force Station (CCAFS), the Spaceflight Meteorology Group at Johnson Space Center and the National Weather Service Office in Melbourne, FL. Its products are used to support NASA's Shuttle and ELV programs as well as Department of Defense and commercial launches from the ER. Shuttle support includes landing sites beyond the ER. The AMU is co-located with the Air Force operational forecasters at CCAFS to facilitate continuous two-way interaction between the AMU and its operational customers. It is operated under a NASA, Air Force, and NWS Memorandum of Understanding (MOU) by a competitively-selected contractor. The contract, which is funded and managed by NASA, provides five full time professionals with degrees in meteorology or related fields, some of whom also have operational experience. NASA provides a Ph.D.- level NASA civil service scientist as Chief of the AMU. The AMU is tasked by its customers through a unique, nationally recognized process. The tasks are limited to development, evaluation and operational transition of technology to improve weather support to spaceport operations and providing expert advice to the customers. The MOU expressly forbids using the AMU resources to conduct operations or do basic research. The presentation will provide a brief overview of the AMU and how it is tasked by its customers to provide high priority products and services. The balance of the presentation will cover a sampling of products

  13. 34 CFR 628.5 - What regulations apply to the Endowment Challenge Grant Program? (United States)


    ... Program? 628.5 Section 628.5 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION ENDOWMENT CHALLENGE GRANT PROGRAM....217. (iv) 34 CFR part 79 (Intergovernmental Review of Department of Education Programs and...

  14. The TangibleK Robotics Program: Applied Computational Thinking for Young Children (United States)

    Bers, Marina U.


    This article describes the TangibleK robotics program for young children. Based on over a decade of research, this program is grounded on the belief that teaching children about the human-made world, the realm of technology and engineering, is as important as teaching them about the natural world, numbers, and letters. The TangibleK program uses…

  15. Proceedings of the African Field Epidemiology Network (AFENET) Scientific Conference 17-22 November 2013 Addis Ababa, Ethiopia: plenaries and oral presentations


    Gitta, Sheba Nakacubo; Mwesiga, Allan; Stanley, Claire; Borchert, Jeff; Mensah, George; Bejtullahu, Armand; Kamadjeu, Raoul; Kebede, Amha; Berhane, Yemane; Jocker, Mathew Lado; Ebontane, Ndode Corlins; Feyissa, Daba; Yeshitila, Kidanie; Mehari, Goitom; Beffa, Gemechu


    Biennially, trainees and graduates of Field Epidemiology and Laboratory Training Programs (FELTPs) are presented with a platform to share investigations and projects undertaken during their two-year training in Applied Epidemiology. The African Field Epidemiology Network (AFENET) Scientific Conference, is a perfect opportunity for public health professionals from various sectors and organizations to come together to discuss issues that impact on public health in Africa. This year's conference...

  16. The role of veterinary epidemiology in combating infectious animal diseases on a global scale: the impact of training and outreach programs. (United States)

    Salman, M D


    The effectiveness of detection and control of highly contagious animal diseases is dependent on a solid understanding of their nature and implementation of scientifically sound methods by people who are well trained. The implementation of specific detection methods and tools requires training and application in natural as well as field conditions. The aim of this paper is to present the design and implementation of training in disease investigation and basic veterinary epidemiology in selected countries using the Highly Pathogenic Avian Influenza (HPAI) H5N1 Asia strain as a disease detection model. Indonesia, Egypt, Nigeria, Turkey, and Vietnam were each identified as either a priority country where AI was spreading rapidly or a country at risk for infection. In each of these countries, a training program on epidemiological concepts, field investigation methodology, and detection of H5N1 Asia strain cases was conducted. This report includes the impact of these training sessions on national animal health programs, including follow-up activities of animal health officers who went through these training sessions.

  17. Best Practices for Improving Capacity Building Outcomes through Professional Training: Insights from NASA's Applied Remote Sensing Training (ARSET) Program (United States)

    Blevins, B.; Mehta, A. V.; Gupta, P.; Prados, A. I.; McCullum, A. J. K.; Schmidt, C.


    NASA's Applied Remote Sensing Training Program (ARSET),, has been providing applied remote sensing training since 2008. To date, the program has reached over 3500 participants, with 1600 stakeholders from 100 countries in 2015 alone. The goals of the program are to develop the technical and analytical skills necessary to utilize NASA resources for decision-support, and to help end-users navigate through the vast, freely available and open data resources. We discuss ARSET's best practices and training approach to improved data access and application of NASA satellite and model data for air quality, water resources, disasters, land, and wildfire management. ARSET follows an iterative approach where the end user community is engaged and data needs input is solicited throughout the training process. End-user data needs and feedback are also incorporated into current and future training content and communicated to NASA Applied Sciences Program principal investigators and data centers responsible for developing NASA tools, portals, data formats, and other data delivery structures. ARSET's success has relied upon 1) targeting outreach to applied science professionals both as training participants and collaborators in developing training activities 2) developing training content tailored to a specific to community's decision support activities and unique environmental challenges 3) promoting interactive forums during trainings to capture and assess end-user needs 4) training scientists within the program in science communication 5) adopting a contextualized gradual learning approach through online and hands-on instruction, and 6) conducting program evaluation, used to assess the benefit of ARSET to program participants and to plan and adapt future training content, methods, and outreach activities.

  18. 20 CFR 408.932 - Will you receive notice of our intention to apply cross-program recovery? (United States)


    ... apply cross-program recovery? 408.932 Section 408.932 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... you the following information: (a) We have determined that you owe a specific overpayment balance that... still owe this overpayment balance; (d) You may request that we withhold a different amount from...

  19. Supporting Adolescent Learning and Development Using Applied Learning Pedagogies in a Regional Secondary School: An Evaluation of a Pilot Program (United States)

    Campbell, Chris; Faulkner, Michael; Pridham, Bruce


    Pedagogies to develop autonomy and social responsibility in early adolescent learners persist as an ongoing agenda for schools. This paper reports on one Australian regional secondary college's pilot program to improve learner engagement in one year 8 class using applied learning principles across the curriculum. In late 2006, participating…

  20. DripFume: A Visual Basic Program For Simulating Distribution And Atmospheric Volatilization Of Soil Fumigants Applied Through Drip Irrigation (United States)

    A Windows-based graphical user interface program (DripFume) was developed in MS Visual Basic (VB) to utilize a two-dimensional multi-phase finite element pesticide transport model to simulate distribution and emission of volatile fumigant chemicals when applied through drip irrigation or shank injec...

  1. 34 CFR 637.3 - What regulations apply to the Minority Science and Engineering Improvement Program? (United States)


    ... Engineering Improvement Program? 637.3 Section 637.3 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND... Department Regulations). (4) 34 CFR part 79 (Intergovernmental Review of Department of Education Programs...

  2. Promoting Behavior Change Using Social Norms: Applying a Community Based Social Marketing Tool to Extension Programming (United States)

    Chaudhary, Anil Kumar; Warner, Laura A.


    Most educational programs are designed to produce lower level outcomes, and Extension educators are challenged to produce behavior change in target audiences. Social norms are a very powerful proven tool for encouraging sustainable behavior change among Extension's target audiences. Minor modifications to program content to demonstrate the…

  3. Genomic Resources for Cancer Epidemiology (United States)

    This page provides links to research resources, complied by the Epidemiology and Genomics Research Program, that may be of interest to genetic epidemiologists conducting cancer research, but is not exhaustive.

  4. What's in a Name? Degree Programs and What They Tell Us about "Applied Linguistics" in Australia (United States)

    Murray, Neil; Crichton, Jonathan


    In this paper we explore the provision of applied linguistics within Australian universities. We focus on how the "what" of applied linguistics, as captured in scholarly definitions of the discipline, accords with the "where", as captured in potential contexts of application as these are manifested in provision. In doing so, we…

  5. What's in a Name? Degree Programs and What They Tell Us about "Applied Linguistics" in Australia (United States)

    Murray, Neil; Crichton, Jonathan


    In this paper we explore the provision of applied linguistics within Australian universities. We focus on how the "what" of applied linguistics, as captured in scholarly definitions of the discipline, accords with the "where", as captured in potential contexts of application as these are manifested in provision. In doing so, we examine the extent…

  6. Paratingent Derivative Applied to the Measure of the Sensitivity in Multiobjective Differential Programming

    Directory of Open Access Journals (Sweden)

    F. García


    Full Text Available We analyse the sensitivity of differential programs of the form subject to where and are maps whose respective images lie in ordered Banach spaces. Following previous works on multiobjective programming, the notion of -optimal solution is used. The behaviour of some nonsingleton sets of -optimal solutions according to changes of the parameter in the problem is analysed. The main result of the work states that the sensitivity of the program is measured by a Lagrange multiplier plus a projection of its derivative. This sensitivity is measured by means of the paratingent derivative.

  7. Object Oriented Mutation Applied in Java Application programming Interface and C++ Classes

    Directory of Open Access Journals (Sweden)

    Mr. Titu Singh Arora


    Full Text Available Mutation analysis is a powerful and computationally expensive technique that measures the effectiveness of test cases for revealing faults. The principal expense of mutation analysis is that many faulty versions of the program under test, culled mutants, must be repeatedly executed. We survey several aspects of reconstruction of complex object-oriented faults on the java API. Application of object-oriented mutation operators in java programs using a parser-based tool can be precise but requires compilation of mutants. In this paper we approach the mutation on Object Oriented features to test the functionality. For this we consider java and C++ programs.

  8. 42 CFR 59.1 - To what programs do these regulations apply? (United States)


    ... of voluntary family planning projects. These projects shall consist of the educational, comprehensive... FOR FAMILY PLANNING SERVICES Project Grants for Family Planning Services § 59.1 To what programs...

  9. Convex quadratic programming applied to the stability number of a graph


    Pacheco, Maria F.; Cardoso, Domingos Moreira; Luz, Carlos J.


    We deal with graphs whose stability number can be determined by a convex quadratic program and describe algorithmic techniques for the determination of maximum stabe sets in such graphs (except there is an induced subgraph with least adjacency eigenvalue and optimal value of the convex quadratic program not changing if the neighbourhood of any vertex is deleted). Such a graph is called adverse. Assuming that every adverse graph has convex-QP stability number, an algorithm for the recognition ...


    Directory of Open Access Journals (Sweden)

    Monalisha Pattnaik


    Full Text Available Background: This paper explores the solutions to the fuzzy optimization linear program problems (FOLPP where some parameters are fuzzy numbers. In practice, there are many problems in which all decision parameters are fuzzy numbers, and such problems are usually solved by either probabilistic programming or multi-objective programming methods. Methods: In this paper, using the concept of comparison of fuzzy numbers, a very effective method is introduced for solving these problems. This paper extends linear programming based problem in fuzzy environment. With the problem assumptions, the optimal solution can still be theoretically solved using the two phase simplex based method in fuzzy environment. To handle the fuzzy decision variables can be initially generated and then solved and improved sequentially using the fuzzy decision approach by introducing robust ranking technique. Results and conclusions: The model is illustrated with an application and a post optimal analysis approach is obtained. The proposed procedure was programmed with MATLAB (R2009a version software for plotting the four dimensional slice diagram to the application. Finally, numerical example is presented to illustrate the effectiveness of the theoretical results, and to gain additional managerial insights. 

  11. 78 FR 32663 - Medicare Program; Notification of Closure of Teaching Hospitals and Opportunity To Apply for... (United States)


    ... for consideration of the direct graduate medical education (GME) and indirect medical education (IME... and Education Reconciliation Act of 2010 (Pub. L. 111-152) (collectively, the ``Affordable Care Act... residency slots after a hospital that trained residents in an approved medical residency program...

  12. Learning Theories Applied to Teaching Technology: Constructivism versus Behavioral Theory for Instructing Multimedia Software Programs (United States)

    Reed, Cajah S.


    This study sought to find evidence for a beneficial learning theory to teach computer software programs. Additionally, software was analyzed for each learning theory's applicability to resolve whether certain software requires a specific method of education. The results are meant to give educators more effective teaching tools, so students…

  13. Applying SNP marker technology in the cacao breeding program at the Cocoa Research Institute of Ghana (United States)

    In this investigation 45 parental cacao plants and five progeny derived from the parental stock studied were genotyped using six SNP markers to determine off-types or mislabeled clones and to authenticate crosses made in the Cocoa Research Institute of Ghana (CRIG) breeding program. Investigation wa...

  14. Applying the creating lasting family connections marriage enhancement program to marriages affected by prison reentry. (United States)

    Shamblen, Stephen R; Arnold, Brooke B; McKiernan, Patrick; Collins, David A; Strader, Ted N


    Divorce proportions are currently high in the US and they are even higher among those who are incarcerated with substance abuse problems. Although much research has examined marital interventions, only two studies have examined marital interventions with prison populations. There is some empirical evidence that incarcerated couples benefit from traditional marital therapy (O'Farrell and Fals-Stewart, 1999, Addictions: A comprehensive guidebook, New York, Oxford University Press). An adaptation of the evidence-based Creating Lasting Family Connections program was implemented with 144 married couples, where one spouse was incarcerated, in a southern state with particularly high divorce and incarceration proportions. Results suggested that married men exposed to the program had larger improvements in some relationship skills relative to a convenience sample of men not so exposed. Both husbands and wives exposed to the program exhibited similar and significant increases in relationship skills. The results were comparable to a Prevention and Relationship Enhancement Program adaptation for inmates. The implications of the findings for prevention practitioners are discussed.

  15. 34 CFR 299.5 - What maintenance of effort requirements apply to ESEA programs? (United States)


    ... aggregate expenditures for the second preceding fiscal year. (b) Applicable programs. This subpart is... funds only if the SEA finds that either the combined fiscal effort per student or the aggregate expenditures of State and local funds with respect to the provision of free public education in the LEA for...

  16. Applying the International Medical Graduate Program Model to Alleviate the Supply Shortage of Accounting Doctoral Faculty (United States)

    HassabElnaby, Hassan R.; Dobrzykowski, David D.; Tran, Oanh Thikie


    Accounting has been faced with a severe shortage in the supply of qualified doctoral faculty. Drawing upon the international mobility of foreign scholars and the spirit of the international medical graduate program, this article suggests a model to fill the demand in accounting doctoral faculty. The underlying assumption of the suggested model is…

  17. 34 CFR 206.5 - What definitions apply to these programs? (United States)


    ... Elementary school EDGAR Facilities Minor remodeling Nonprofit Private Project Public Secondary school... in a State; (ii) Is authorized by that State to provide a program of education beyond secondary...: (A) Has a secondary school diploma; (B) Has the recognized equivalent of a secondary school...

  18. Study of author’s applied physical training program for military officers-graduates of reserve officers’ departments


    Yavorskyy A.I.


    Urpose: to test effectiveness of applied physical training program for military officers, called up to military service after graduation from reserve officers’ departments. Material: the research was conducted on the base of Educational center 184 from June 2014 to December 2015. In the research 80 military officers participated (n=30 - graduates of military higher educational establishments; n=26, n=24 - graduates of reserve officers’ departments) of 22-27 years’ age. Results: we fulfilled a...

  19. Social Science at the Center for Adaptive Optics: Synergistic Systems of Program Evaluation, Applied Research, Educational Assessment, and Pedagogy (United States)

    Goza, B. K.; Hunter, L.; Shaw, J. M.; Metevier, A. J.; Raschke, L.; Espinoza, E.; Geaney, E. R.; Reyes, G.; Rothman, D. L.


    This paper describes the interaction of four elements of social science as they have evolved in concert with the Center for Adaptive Optics Professional Development Program (CfAO PDP). We hope these examples persuade early-career scientists and engineers to include social science activities as they develop grant proposals and carry out their research. To frame our discussion we use a metaphor from astronomy. At the University of California Santa Cruz (UCSC), the CfAO PDP and the Educational Partnership Center (EPC) are two young stars in the process of forming a solar system. Together, they are surrounded by a disk of gas and dust made up of program evaluation, applied research, educational assessment, and pedagogy. An idea from the 2001 PDP intensive workshops program evaluation developed into the Assessing Scientific Inquiry and Leadership Skills (AScILS) applied research project. In iterative cycles, AScILS researchers participated in subsequent PDP intensive workshops, teaching social science while piloting AScILS measurement strategies. Subsequent "orbits" of the PDP program evaluation gathered ideas from the applied research and pedagogy. The denser regions of this disk of social science are in the process of forming new protoplanets as tools for research and teaching are developed. These tools include problem-solving exercises or simulations of adaptive optics explanations and scientific reasoning; rubrics to evaluate the scientific reasoning simulation responses, knowledge regarding inclusive science education, and student explanations of science/engineering inquiry investigations; and a scientific reasoning curriculum. Another applied research project is forming with the design of a study regarding how to assess engineering explanations. To illustrate the mutual shaping of the cross-disciplinary, intergenerational group of educational researchers and their projects, the paper ends with a description of the professional trajectories of some of the

  20. Using Technology to Expand and Enhance Applied Behavioral Analysis Programs for Children with Autism in Military Families (United States)


    producing outcome data on the effectiveness of our technology-enhanced in-home services for children with autism spectrum disorders (Experiment 3...with autism for our technology-enhanced early-intervention aim (Experiment 3). 25 Key Research Accomplishments...Award Number: W81XWH-11-1-0444 TITLE: "Using Technology to Expand and Enhance Applied Behavioral Analysis Programs for Children with Autism in

  1. Program Applied Biology and Biotechnology. Annual report 1986. Programm Angewandte Biologie und Biotechnologie. Jahresbericht 1986

    Energy Technology Data Exchange (ETDEWEB)


    BMFT-funded research projects in 1986 on the sector 'Applied Biology and Biotechnology' are reviewed. The main fields of research were: Microbiological screening methods, waste water, refuse and soil microbiology, genetic engineering, cell cultures, development of new bioreactor systems, measurement and control, biocatalysts, plant cultivation, safety research, biosensory research, biomass utilisation.

  2. The Investigation of Physical Performance Status of Visually and Hearing Impaired Applying Judo Training Program (United States)

    Karakoc, Onder


    It was aimed to investigate the physical performances of visually and hearing impaired doing judo training in this study. 32 male athletes, who were doing judo training, volunteer and, visually and hearing impaired, participated in this study. The investigation was applied to visually impaired (N = 12, mean ± SD; age: 25.75 ± 3.55 years, height:…

  3. 34 CFR 645.6 - What definitions apply to the Upward Bound Program? (United States)


    ... to learn successfully in classrooms in which English is the language of instruction. Low-income individual means an individual whose family taxable income did not exceed 150 percent of the poverty level... definitions also apply to this part: Family taxable income means— (1) With regard to a dependent student,...

  4. Study of author’s applied physical training program for military officers-graduates of reserve officers’ departments

    Directory of Open Access Journals (Sweden)

    Yavorskyy A.I.


    Full Text Available Urpose: to test effectiveness of applied physical training program for military officers, called up to military service after graduation from reserve officers’ departments. Material: the research was conducted on the base of Educational center 184 from June 2014 to December 2015. In the research 80 military officers participated (n=30 - graduates of military higher educational establishments; n=26, n=24 - graduates of reserve officers’ departments of 22-27 years’ age. Results: we fulfilled analysis of military officers’ physical fitness by exercises, which characterize general physical fitness and military applied skills (100 meters’ run, chin ups, 3000 meters’ run, passing obstacles course, grenade throws for distance and for accuracy, 5 km march-rush. We worked out the program, the essence of which implies ensuring of physical fitness and acceleration of reserve officers-graduates’ adaptation to professional (combat functioning. Conclusions: it was proved that implementation of the author’s program influenced positively on perfection of general physical qualities and military applied skills of military officers-graduated of reserve officers’ departments (р<0.05-0.001.

  5. Applying a competencies system at the master programs according to professional associations


    Sipos Ciprian; Alexandru BUGLEA


    The purpose of this paper is to create the premises for a system of competencies in Romania coherent with the European regulations at master level in the area of economic analysis and valuation of businesses, real estates and financial assets, according to the requirements of professional associations. The master programs organized by universities should be based on a system of competencies adapted to the requirements of business environment and professional associations, considering the Roma...

  6. Feasibility of Applying the Finite Element Adaptive Research Solver (FEARS) Program to the Plate Bending Problem. (United States)


    Ship Research and Program emen Development Center Task Area ZR0140201 Bethesda, Maryland 20084 Work Unit 1844-140 II . CONTROLLING OFFICE NAME AND ADDRESS...solution has singular behavior, then only the norm II .112 can be used. This approach has the following several advantages and disadvantages: 1) Advantages...34 Bollettino Unione Matematica Italiana, Bologna, Vol. 10, pp. 133-140 (1974). 14. Ciarlet, P. and P. aviart, "A Mixed Finite Element Method for the Biharmonic

  7. Applied Grant Writing Training for Future Health Communication Researchers: The Health Communication Scholars Program. (United States)

    Mackert, Michael; Donovan, Erin E; Bernhardt, Jay M


    Health communication faculty face increasing expectations regarding their academic productivity, including the expectation to seek and secure external funding. Doctoral training in health communication that does not fully prepare students for the challenges of securing external funding is doing them a disservice that will make them less competitive for academic positions and less likely to succeed in the academic positions they assume. The purpose of this study is to share the evaluation of a program, the Health Communication Scholars Program (HCSP), designed to train future health communication researchers in the pursuit of external funding. The HCSP includes a grant-writing workshop, requires interdisciplinary graduate student teams to submit applications, and awards funding to top proposals. HCSP participants responding to an evaluation survey (N = 25) had overwhelmingly positive experiences; respondents felt the program provided great value, improved their writing skills, gave them skills to pursue funding in the future, and helped them secure tenure-track faculty positions. The results of this formal evaluation suggest the HCSP is an experience that builds crucial skills and prepares graduate students for the demands they will face as faculty. It is a relatively low-cost, replicable model that merits consideration and adoption at other institutions that hope to provide professional development for doctoral students interested in health communication.


    Directory of Open Access Journals (Sweden)

    Jaime Williams


    Full Text Available Mental health day treatment (MHDT programs provide intensive group psychotherapy for patients with psychiatric pathology complicated by personality disorder. Recently, researchers have begun to examine specific components of these programs. Of importance is the theoretical rationale, which may be challenging to understand given the complexity of the treatment. The purpose of this project was to investigate the theory of one MHDT program. Community-based participatory research was chosen and accordingly, all stages of the project were collaborative with the MHDT clinical team. We engaged in a six-month, iterative process of weekly action-reflection cycles wherein material was discussed, analyzed for themes, and the findings presented back to the team to further the conversation. Results summarize this program’s Theories of Dysfunction and Therapeutic Change, which were primarily psychodynamic, but also integrative through assimilation of elements from other paradigms. Usefulness of the research process is discussed and recommendations are provided for others wishing to undergo a similar process.

  9. Building capacity for water, sanitation, and hygiene programming: Training evaluation theory applied to CLTS management training in Kenya. (United States)

    Crocker, Jonny; Shields, Katherine F; Venkataramanan, Vidya; Saywell, Darren; Bartram, Jamie


    Training and capacity building are long established critical components of global water, sanitation, and hygiene (WaSH) policies, strategies, and programs. Expanding capacity building support for WaSH in developing countries is one of the targets of the Sustainable Development Goals. There are many training evaluation methods and tools available. However, training evaluations in WaSH have been infrequent, have often not utilized these methods and tools, and have lacked rigor. We developed a conceptual framework for evaluating training in WaSH by reviewing and adapting concepts from literature. Our framework includes three target outcomes: learning, individual performance, and improved programming; and two sets of influences: trainee and context factors. We applied the framework to evaluate a seven-month community-led total sanitation (CLTS) management training program delivered to 42 government officials in Kenya from September 2013 to May 2014. Trainees were given a pre-training questionnaire and were interviewed at two weeks and seven months after initial training. We qualitatively analyzed the data using our conceptual framework. The training program resulted in trainees learning the CLTS process and new skills, and improving their individual performance through application of advocacy, partnership, and supervision soft skills. The link from trainees' performance to improved programming was constrained by resource limitations and pre-existing rigidity of trainees' organizations. Training-over-time enhanced outcomes and enabled trainees to overcome constraints in their work. Training in soft skills is relevant to managing public health programs beyond WaSH. We make recommendations on how training programs can be targeted and adapted to improve outcomes. Our conceptual framework can be used as a tool both for planning and evaluating training programs in WaSH.

  10. Approach of Separately Applying Unit Testing to AspectJ Program

    Institute of Scientific and Technical Information of China (English)

    GU Hai-bo; LU Yan-sheng


    A unit testing approach for AspectJ programs is proposed to separately test aspect units which have their own states. In the approach, aspects under test are converted to classes before execution of unit testing. In the conversion process, the context information passed through pointcut is transformed into advices, then the advices are converted to class member methods, and conflicts in the conversion result, if any, are resolved finally. The unit testing process consists of generating test cases, executing test cases and checking results.

  11. Efficient Parallelization of the Stochastic Dual Dynamic Programming Algorithm Applied to Hydropower Scheduling

    Directory of Open Access Journals (Sweden)

    Arild Helseth


    Full Text Available Stochastic dual dynamic programming (SDDP has become a popular algorithm used in practical long-term scheduling of hydropower systems. The SDDP algorithm is computationally demanding, but can be designed to take advantage of parallel processing. This paper presents a novel parallel scheme for the SDDP algorithm, where the stage-wise synchronization point traditionally used in the backward iteration of the SDDP algorithm is partially relaxed. The proposed scheme was tested on a realistic model of a Norwegian water course, proving that the synchronization point relaxation significantly improves parallel efficiency.

  12. [Future prospects of molecular epidemiology in tuberculosis]. (United States)

    Matsumoto, Tomoshige; Iwamoto, Tomotada


    easily compare the genotypic data of independent studies between different laboratories. With the advantages, VNTR surpassed IS6110 RFLP and became the first line genotyping method in molecular epidemiology. One of the most attractive potentials on this method is its applicability for establishment of the database of M. tuberculosis genotype which covers not only local area but also world wide scale. This would open the door to "in silico epidemiology" which brings a breakthrough on the current TB control program. The optimization and standardization of the combination of VNTR loci for strain genotyping is the only but hard issue for the development of global database system. Road to the global Mtb genotype database is hard, but we believe, "Yes, We Can!". Another attractive potential of VNTR is its use for phylogenetic analysis, although more intensive research on this with using comprehensive marker sets, such as large sequence polymorphisms and single-nucleotide polymorphisms are required. Again, with the advantages of VNTR analysis, i.e., easy, rapid, specific, and digit-based data, VNTR became the first line method in molecular epidemiology. Molecular epidemiology of tuberculosis is expanding its research field from the investigation of TB transmission to more basic science such as evolution and phylogeographic distribution. In this symposium, we have invited four opinion leaders in molecular epidemiology of TB in Japan who are talking about each title as followed. 1. Establishment of the standard VNTR analysis systems for Tuberculosis (TB) and preparation of databases for TB genotyping: Shinji MAEDA and Yoshiro MURASE (Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, JATA). We have already reported the JATA (12)-VNTR system for TB genotyping in Japan. However, by comparison of cluster formation rate, the discrimination power of JATA (12)-VNTR was lower than that of IS6110 RFLP analysis. Therefore, we improved the JATA (12

  13. Epidemiological evidence in forensic pharmacovigilance. (United States)

    Persaud, Nav; Healy, David


    Until recently epidemiological evidence was not regarded as helpful in determining cause and effect. It generated associations that then had to be explained in terms of bio-mechanisms and applied to individual patients. A series of legal cases surrounding possible birth defects triggered by doxylamine (Bendectin) and connective tissue disorders linked to breast implants made it clear that in some instances epidemiological evidence might have a more important role, but the pendulum swung too far so that epidemiological evidence has in recent decades been given an unwarranted primacy, partly perhaps because it suits the interests of certain stakeholders. Older and more recent epidemiological studies on doxylamine and other antihistamines are reviewed to bring out the ambiguities and pitfalls of an undue reliance on epidemiological studies.

  14. Program for fundamental and applied research of fuel cells in VNIIEF

    Energy Technology Data Exchange (ETDEWEB)

    Anisin, A.V.; Borisseonock, V.A.; Novitskii, Y.Z.; Potyomckin, G.A.


    According to VNIIEF the integral part of development of fuel cell power plants is fundamental and applied research. This paper describes areas of research on molten carbonate fuel cells. Topics include the development of mathematical models for porous electrodes, thin film electrolytes, the possibility of solid nickel anodes, model of activation polarization of anode, electrolyte with high solubility of oxygen. Other areas include research on a stationary mode of stack operation, anticorrosion coatings, impedance diagnostic methods, ultrasound diagnostics, radiation treatments, an air aluminium cell, and alternative catalysts for low temperature fuel cells.

  15. Applying an innovative educational program for the education of today's engineers (United States)

    Kans, M.


    Engineers require a broad spectrum of knowledge and skills: basic skills in mathematics and physics, skills and competencies within the major subject area as well as more general knowledge about business and enterprise contexts, society regulations and understanding of the future professions' characteristics. In addition, social, intercultural, analytical and managing competencies are desired. The CDIO educational program was initiated as a means to come closer to practice and to assure the training of engineering skills that are required of today's engineers. CDIO is short for Conceive-Design-Implement-Operate and describes the full life cycle understanding of a system or asset that engineering students should reach during education. The CDIO initiative is formulated in a program consisting of two important documents: the CDIO standards and the CDIO syllabus. The standards describe a holistic approach on education, from knowledge and skills to be trained, how to train and assess them, to how to develop the teaching staff and the work places for enabling the goals. The specific knowledge and skills to be achieved are accounted for in the syllabus. In this paper we share our more than 15 years of experiences in problem and project based learning from the perspective of the CDIO standards. For each standard, examples of how to set up the education and overcome challenges connected to the standard are given. The paper concludes with recommendations to others wishing to work toward problem and real-life based education without compromising the requirements of a scientific approach.

  16. Epidemiological criminology: drug use among African American gang members. (United States)

    Lanier, Mark M; Pack, Robert P; Akers, Timothy A


    Epidemiological methods and public health theories can be tied to theories of crime and delinquency and used to create evidence-based policy. Interdisciplinary theoretical approaches to existing, and emerging, public health and criminal justice problems hold great promise. Differential association theory postulates that close association with delinquent peers leads to an increase in deviant activities such as illicit drug use. Social cognitive theory postulates that health behavior change is driven by the interaction of (a) cognitive states that support a health outcome, (b) the social and contextual environment, (c) and individual action. Combined, these theories can be applied to drug eradication programs as well as other health and crime issues. Focus groups and interviews were performed to identify rates of illicit substance use among incarcerated African American adolescent male gang members and nongang members. The policy recommendations illustrate the convergence of criminological and epidemiological theory under the new paradigm of epidemiological criminology or ''EpiCrim.''

  17. Software IV and V Research Priorities and Applied Program Accomplishments Within NASA (United States)

    Blazy, Louis J.


    The mission of this research is to be world-class creators and facilitators of innovative, intelligent, high performance, reliable information technologies that enable NASA missions to (1) increase software safety and quality through error avoidance, early detection and resolution of errors, by utilizing and applying empirically based software engineering best practices; (2) ensure customer software risks are identified and/or that requirements are met and/or exceeded; (3) research, develop, apply, verify, and publish software technologies for competitive advantage and the advancement of science; and (4) facilitate the transfer of science and engineering data, methods, and practices to NASA, educational institutions, state agencies, and commercial organizations. The goals are to become a national Center Of Excellence (COE) in software and system independent verification and validation, and to become an international leading force in the field of software engineering for improving the safety, quality, reliability, and cost performance of software systems. This project addresses the following problems: Ensure safety of NASA missions, ensure requirements are met, minimize programmatic and technological risks of software development and operations, improve software quality, reduce costs and time to delivery, and improve the science of software engineering

  18. Epidemiological causality. (United States)

    Morabia, Alfredo


    Epidemiological methods, which combine population thinking and group comparisons, can primarily identify causes of disease in populations. There is therefore a tension between our intuitive notion of a cause, which we want to be deterministic and invariant at the individual level, and the epidemiological notion of causes, which are invariant only at the population level. Epidemiologists have given heretofore a pragmatic solution to this tension. Causal inference in epidemiology consists in checking the logical coherence of a causality statement and determining whether what has been found grossly contradicts what we think we already know: how strong is the association? Is there a dose-response relationship? Does the cause precede the effect? Is the effect biologically plausible? Etc. This approach to causal inference can be traced back to the English philosophers David Hume and John Stuart Mill. On the other hand, the mode of establishing causality, devised by Jakob Henle and Robert Koch, which has been fruitful in bacteriology, requires that in every instance the effect invariably follows the cause (e.g., inoculation of Koch bacillus and tuberculosis). This is incompatible with epidemiological causality which has to deal with probabilistic effects (e.g., smoking and lung cancer), and is therefore invariant only for the population.

  19. Applying Geospatial Semantic Array Programming for a Reproducible Set of Bioclimatic Indices in Europe

    CERN Document Server

    Caudullo, Giovanni


    Bioclimate-driven regression analysis is a widely used approach for modelling ecological niches and zonation. Although the bioclimatic complexity of the European continent is high, a particular combination of 12 climatic and topographic covariates was recently found able to reliably reproduce the ecological zoning of the Food and Agriculture Organization of the United Nations (FAO) for forest resources assessment at pan-European scale, generating the first fuzzy similarity map of FAO ecozones in Europe. The reproducible procedure followed to derive this collection of bioclimatic indices is now presented. It required an integration of data-transformation modules (D-TM) using geospatial tools such as Geographic Information System (GIS) software, and array-based mathematical implementation such as semantic array programming (SemAP). Base variables, intermediate and final covariates are described and semantically defined by providing the workflow of D-TMs and the mathematical formulation following the SemAP notat...

  20. Analysis of data from radioactive wastes treatment process and implementation of a data management applied program

    Energy Technology Data Exchange (ETDEWEB)

    Jeo, H. S.; Son, J. S.; Kim, T. K.; Kang, I. S.; Lee, Y. H [KAERI, Taejon (Korea, Republic of)


    As for the generated radioactive waste, a nuclide and a form are various, and by small quantity occurs the irregular times in KAERI. Record management of a radioactive waste personal history is an important element in disposal. A data collection of a liquid / solid radioactive waste treatment process of a research organization became necessary while developing the RAWMIS which it can generate personal history management for efficient management of a waste, documents, all kinds of statistics. This paper introduces an input and output application program design to do to database with data in the results and a stream process of a treatment that analyzed the waste occurrence present situation and data by treatment process. Data on the actual treatment process that is not limited experiment improve by a document, human traces, saving of material resources and improve with efficiency of tracking about a radioactive waste and a process and give help to radioactive waste material valance and inventory study.

  1. Ecological Forecasting in the Applied Sciences Program and Input to the Decadal Survey (United States)

    Skiles, Joseph


    Ecological forecasting uses knowledge of physics, ecology and physiology to predict how ecosystems will change in the future in response to environmental factors. Further, Ecological Forecasting employs observations and models to predict the effects of environmental change on ecosystems. In doing so, it applies information from the physical, biological, and social sciences and promotes a scientific synthesis across the domains of physics, geology, chemistry, biology, and psychology. The goal is reliable forecasts that allow decision makers access to science-based tools in order to project changes in living systems. The next decadal survey will direct the development Earth Observation sensors and satellites for the next ten years. It is important that these new sensors and satellites address the requirements for ecosystem models, imagery, and other data for resource management. This presentation will give examples of these model inputs and some resources needed for NASA to continue effective Ecological Forecasting.

  2. Selection of patients from myocardial perfusion scintigraphy based on fuzzy sets theory applied to clinical-epidemiological data and treadmill test results

    Energy Technology Data Exchange (ETDEWEB)

    Duarte, P.S. [Fleury - Centro de Medicina Diagnostica, Sao Paulo, SP (Brazil). Secao de Medicina Nuclear]. E-mail:; Mastrocolla, L.E.; Farsky, P.S.; Sampaio, C.R.E.P.S. [Fleury - Centro de Medicina Diagnostica, Sao Paulo, SP (Brazil). Secao de Cardiologia; Tonelli, P.A. [Sao Paulo Univ., SP (Brazil). Inst. de Matematica e Estatistica; Barros, L.C. [Universidade Estadual de Campinas , SP (Brazil). Inst. de Matematica, Estatistica e Computacao Cientifica; Ortega, N.R. [Sao Paulo Univ., SP (Brazil). Informatica Medica; Pereira, J.C.R. [Sao Paulo Univ., SP (Brazil). Faculdade de Saude Publica. Dept. de Epidemiologia


    Coronary artery disease (CAD) is a worldwide leading cause of death. The standard method for evaluating critical partial occlusions is coronary arteriography, a catheterization technique which is invasive, time consuming, and costly. There are noninvasive approaches for the early detection of CAD. The basis for the noninvasive diagnosis of CAD has been laid in a sequential analysis of the risk factors, and the results of the treadmill test and myocardial perfusion scintigraphy (MPS). Many investigators have demonstrated that the diagnostic applications of MPS are appropriate for patients who have an intermediate likelihood of disease. Although this information is useful, it is only partially utilized in clinical practice due to the difficulty to properly classify the patients. Since the seminal work of Lotfi Zadeh, fuzzy logic has been applied in numerous areas. In the present study, we proposed and tested a model to select patients for MPS based on fuzzy sets theory. A group of 1053 patients was used to develop the model and another group of 1045 patients was used to test it. Receiver operating characteristic curves were used to compare the performance of the fuzzy model against expert physician opinions, and showed that the performance of the fuzzy model was equal or superior to that of the physicians. Therefore, we conclude that the fuzzy model could be a useful tool to assist the general practitioner in the selection of patients for MPS. (author)

  3. Session 6: Infant nutrition: future research developments in Europe EARNEST, the early nutrition programming project: EARly Nutrition programming - long-term Efficacy and Safety Trials and integrated epidemiological, genetic, animal, consumer and economic research. (United States)

    Fewtrell, M S


    Increasing evidence from lifetime experimental studies in animals and observational and experimental studies in human subjects suggests that pre- and postnatal nutrition programme long-term health. However, key unanswered questions remain on the extent of early-life programming in contemporary European populations, relevant nutritional exposures, critical time periods, mechanisms and the effectiveness of interventions to prevent or reverse programming effects. The EARly Nutrition programming - long-term Efficacy and Safety Trials and integrated epidemiological, genetic, animal, consumer and economic research (EARNEST) consortium brings together a multi-disciplinary team of scientists from European research institutions in an integrated programme of work that includes experimental studies in human subjects, modern prospective observational studies and mechanistic animal work including physiological studies, cell-culture models and molecular techniques. Theme 1 tests early nutritional programming of disease in human subjects, measuring disease markers in childhood and early adulthood in nineteen randomised controlled trials of nutritional interventions in pregnancy and infancy. Theme 2 examines associations between early nutrition and later outcomes in large modern European population-based prospective studies, with detailed measures of diet in pregnancy and early life. Theme 3 uses animal, cellular and molecular techniques to study lifetime effects of early nutrition. Biomedical studies are complemented by studies of the social and economic importance of programming (themes 4 and 5), and themes encouraging integration, communication, training and wealth creation. The project aims to: help formulate policies on the composition and testing of infant foods; improve the nutritional value of infant formulas; identify interventions to prevent and reverse adverse early nutritional programming. In addition, it has the potential to develop new products through industrial

  4. A mixed integer linear programming model applied in barge planning for Omya

    Directory of Open Access Journals (Sweden)

    David Bredström


    Full Text Available This article presents a mathematical model for barge transport planning on the river Rhine, which is part of a decision support system (DSS recently taken into use by the Swiss company Omya. The system is operated by Omya’s regional office in Cologne, Germany, responsible for distribution planning at the regional distribution center (RDC in Moerdijk, the Netherlands. The distribution planning is a vital part of supply chain management of Omya’s production of Norwegian high quality calcium carbonate slurry, supplied to European paper manufacturers. The DSS operates within a vendor managed inventory (VMI setting, where the customer inventories are monitored by Omya, who decides upon the refilling days and quantities delivered by barges. The barge planning problem falls into the category of inventory routing problems (IRP and is further characterized with multiple products, heterogeneous fleet with availability restrictions (the fleet is owned by third party, vehicle compartments, dependency of barge capacity on water-level, multiple customer visits, bounded customer inventories and rolling planning horizon. There are additional modelling details which had to be considered to make it possible to employ the model in practice at a sufficient level of detail. To the best of our knowledge, we have not been able to find similar models covering all these aspects in barge planning. This article presents the developed mixed-integer programming model and discusses practical experience with its solution. Briefly, it also puts the model into the context of the entire business case of value chain optimization in Omya.

  5. Applying Geospatial Technologies for International Development and Public Health: The USAID/NASA SERVIR Program (United States)

    Hemmings, Sarah; Limaye, Ashutosh; Irwin, Dan


    Background: SERVIR -- the Regional Visualization and Monitoring System -- helps people use Earth observations and predictive models based on data from orbiting satellites to make timely decisions that benefit society. SERVIR operates through a network of regional hubs in Mesoamerica, East Africa, and the Hindu Kush-Himalayas. USAID and NASA support SERVIR, with the long-term goal of transferring SERVIR capabilities to the host countries. Objective/Purpose: The purpose of this presentation is to describe how the SERVIR system helps the SERVIR regions cope with eight areas of societal benefit identified by the Group on Earth Observations (GEO): health, disasters, ecosystems, biodiversity, weather, water, climate, and agriculture. This presentation will describe environmental health applications of data in the SERVIR system, as well as ongoing and future efforts to incorporate additional health applications into the SERVIR system. Methods: This presentation will discuss how the SERVIR Program makes environmental data available for use in environmental health applications. SERVIR accomplishes its mission by providing member nations with access to geospatial data and predictive models, information visualization, training and capacity building, and partnership development. SERVIR conducts needs assessments in partner regions, develops custom applications of Earth observation data, and makes NASA and partner data available through an online geospatial data portal at Results: Decision makers use SERVIR to improve their ability to monitor air quality, extreme weather, biodiversity, and changes in land cover. In past several years, the system has been used over 50 times to respond to environmental threats such as wildfires, floods, landslides, and harmful algal blooms. Given that the SERVIR regions are experiencing increased stress under larger climate variability than historic observations, SERVIR provides information to support the development of

  6. Required Assets for a Nuclear Energy Applied R&D Program

    Energy Technology Data Exchange (ETDEWEB)

    Harold F. McFarlane; Craig L. Jacobson


    This report is one of a set of three documents that have collectively identified and recommended research and development capabilities that will be required to advance nuclear energy in the next 20 to 50 years. The first report, Nuclear Energy for the Future: Required Research and Development Capabilities—An Industry Perspective, was produced by Battelle Memorial Institute at the request of the Assistant Secretary of Nuclear Energy. That report, drawn from input by industry, academia, and Department of Energy laboratories, can be found in Appendix 5.1. This Idaho National Laboratory report maps the nuclear-specific capabilities from the Battelle report onto facility requirements, identifying options from the set of national laboratory, university, industry, and international facilities. It also identifies significant gaps in the required facility capabilities. The third document, Executive Recommendations for Nuclear R&D Capabilities, is a letter report containing a set of recommendations made by a team of senior executives representing nuclear vendors, utilities, academia, and the national laboratories (at Battelle’s request). That third report can be found in Appendix 5.2. The three reports should be considered as set in order to have a more complete picture. The basis of this report was drawn from three sources: previous Department of Energy reports, workshops and committee meetings, and expert opinion. The facilities discussed were winnowed from several hundred facilities that had previously been catalogued and several additional facilities that had been overlooked in past exercises. The scope of this report is limited to commercial nuclear energy and those things the federal government, or more specifically the Office of Nuclear Energy, should do to support its expanded deployment in order to increase energy security and reduce carbon emissions. In the context of this report, capabilities mean innovative, well-structured research and development programs

  7. Use of Pneumococcal Disease Epidemiology to Set Policy and Prevent Disease during 20 Years of the Emerging Infections Program (United States)

    Whitney, Cynthia G.


    Two decades ago, the Emerging Infections Program of the US Centers for Disease Control and Prevention implemented what seemed like a simple yet novel idea: a population- and laboratory-based surveillance system designed to identify and characterize invasive bacterial infections, including those caused by Streptococcus pneumoniae. This system, known as Active Bacterial Core surveillance, has since served as a flexible platform for following trends in invasive pneumococcal disease and studying vaccination as the most effective method for prevention. We report the contributions of Active Bacterial Core surveillance to every pneumococcal vaccine policy decision in the United States during the past 20 years. PMID:26291238

  8. Is the effect of job strain on myocardial infarction risk due to interaction between high psychological demands and low decision latitude? Results from Stockholm Heart Epidemiology Program (SHEEP). (United States)

    Hallqvist, J; Diderichsen, F; Theorell, T; Reuterwall, C; Ahlbom, A


    The objectives are to examine if the excess risk of myocardial infarction from exposure to job strain is due to interaction between high demands and low control and to analyse what role such an interaction has regarding socioeconomic differences in risk of myocardial infarction. The material is a population-based case-referent study having incident first events of myocardial infarction as outcome (SHEEP: Stockholm Heart Epidemiology Program). The analysis is restricted to males 45-64 yr of age with a more detailed analysis confined to those still working at inclusion. In total, 1047 cases and 1450 referents were included in the analysis. Exposure categories of job strain were formed from self reported questionnaire information. The results show that high demands and low decision latitude interact with a synergy index of 7.5 (95% C.I.: 1.8-30.6) providing empirical support for the core mechanism of the job strain model. Manual workers are more susceptible when exposed to job strain and its components and this increased susceptibility explains about 25-50% of the relative excess risk among manual workers. Low decision latitude may also, as a causal link, explain about 30% of the socioeconomic difference in risk of myocardial infarction. The distinction between the interaction and the causal link mechanisms identifies new etiologic questions and intervention alternatives. The specific causes of the increased susceptibility among manual workers to job strain and its components seem to be an interesting and important research question.

  9. Changes in the epidemiology of hepatitis A outbreaks 13 years after the introduction of a mass vaccination program. (United States)

    Martínez, Ana; Broner, Sonia; Sala, M Rosa; Manzanares-Laya, Sandra; Godoy, Pere; Planas, Caritat; Minguell, Sofia; Torner, Nuria; Jané, Mireia; Domínguez, Angela; For The Study Of The Immune Status In Health Care, The Working Group; Hepatitis A In Catalonia, For The Study Of


    A hepatitis A+B vaccine vaccination program of 12-year-olds was introduced in Catalonia in 1998. The aim of this study was to investigate the evolution of hepatitis A outbreaks in Catalonia and estimate the preventable fraction of cases associated with outbreaks as a measure of the impact of the vaccination program. Hepatitis A outbreaks reported to the Health Department between 1991 and 2012 were analyzed. The incidence rates of outbreaks, outbreak-associated cases and hospitalizations were calculated. The preventable fraction (PF) and 95% confidence intervals (CI) were estimated for the whole study period (pre-vaccination and post-vaccination) and the post-vaccination period.   One-hundred-eight (108) outbreaks (rate of 2.21 per 10(6) persons-year) were reported in the pre-vaccination period and 258 outbreaks (rate of 2.82 per 10(6) persons-year) in the post-vaccination period. The rate of cases associated with outbreaks was 1.52 per 10(5) persons-year in the pre-vaccination period and 1.28 per 10(5) persons-year in the post-vaccination period. Hospitalization rates were 0.08 and 0.75 per 10(6) persons-year, respectively. The number of person-to-person outbreaks whose index case was a school contact decreased in the post-vaccination period (aOR 2.72; 95%CI 1.35-5.48), but outbreaks whose index case was a man who has sex with men (MSM) or an immigrant increased. The PF of all outbreak-associated cases was 6.46% (95%CI 3.11-9.82) and the highest PF was in the 15-24 years age group (42.53%; 95%CI 29.30-55.75). In the 0-4 years age group, the PF was 18.35% (95%CI 9.59-27.11), suggesting a protective herd effect in unvaccinated subjects. Vaccination of immigrants traveling to endemic countries and MSM should be reinforced.

  10. Derivation and Comparative Study on Centroid Ranking Value of TrIFN and Apply on Fuzzy Geometric Programming

    Directory of Open Access Journals (Sweden)

    Soham Bandyopadhyay


    Full Text Available Ranking fuzzy numbers has become an important process in decision making. Many ranking methods have been proposed thus far and one of the commonly used is centroid of trapezoid. Here we try to derive detail mathematical derivation of centroids of a Trapezoidal Intuitionistic Fuzzy Number along x and y axis. After that we derive the ranking value from two centroid along x and y axis. At the end of the article ranking value on fuzzy geometric programming is used. Here we are dealing with three strong decision making concepts. Intuitionistic trapezoidal fuzzy system is much more decision oriented approach than normal fuzzy number in real life uncertain environment, where we can apply membership and non membership concept for analyzing any real life situation. Ranking value, based on centroid of any Trapezoidal Intuitionistic Fuzzy Number helps for conclusion derivation in quantitative way. We here choose most powerful non linear optimization tool, geometrical programming technique, for generating any decision, using Trapezoidal Intuitionistic Fuzzy Number with centroid ranking approach.

  11. Thermodynamic design of a cascade refrigeration system of liquefied natural gas by applying mixed integer non-linear programming

    Institute of Scientific and Technical Information of China (English)

    Meysam Kamalinejad; Majid Amidpour; S.M. Mousavi Naeynian


    Liquefied natural gas (LNG) is the most economical way of transporting natural gas (NG) over long distances. Liq-uefaction of NG using vapor compression refrigeration system requires high operating and capital cost. Due to lack of systematic design methods for multistage refrigeration cycles, conventional approaches to determine op-timal cycle are largely trial-and-error. In this paper a novel mixed integer non-linear programming (MINLP) model is introduced to select optimal synthesis of refrigeration systems to reduce both operating and capital costs of an LNG plant. Better conceptual understanding of design improvement is illustrated on composite curve (CC) and exergetic grand composite curve (EGCC) of pinch analysis diagrams. In this method a superstruc-ture representation of complex refrigeration system is developed to select and optimize key decision variables in refrigeration cycles (i.e. partition temperature, compression configuration, refrigeration features, refrigerant flow rate and economic trade-off). Based on this method a program (LNG-Pro) is developed which integrates VBA, Refprop and Excel MINLP Solver to automate the methodology. Design procedure is applied on a sample LNG plant to illustrate advantages of using this method which shows a 3.3% reduction in total shaft work consumption.

  12. Scaling through pair-wise comparison method in required characteristics of students applying for post graduate programs

    Directory of Open Access Journals (Sweden)

    Nese Güler


    Full Text Available The Aim and Significance of the Research: The characteristics that lecturers wish students applying for post-graduate programs should possess are determined in this paper quantitatively through pairwise comparisons according to the lecturers' responses.  The fact that resources and studies concerning the issue of scaling are scarcely available has been the most significant driving force for researchers to conduct research on this issue. It is believed that this research will make contributions to the field of scaling, which has limited number of studies. Since this research is a work of scaling which is rarely seen in the field of education, it is thought that the research is significant. Method of Research: The research was conducted on the 129 lecturers working in the different departments of Hacettepe University in the fall and spring semesters in the 2006 - 2007 academic year. At the stage of preparing the tool of measurement, the 7 characteristics that were required students should possess for selection to post-graduate education programs were determined and a tool of measurement through which pairwise comparisons would be made were designed.  Consequently, the scale value for each characteristic was marked on the line of numbers. Findings and Comments: According to the pairwise comparison, academic achievement score is in the first order. This is followed by the score gained in the interview, the purpose in entering the department, their level of English proficiency, ALES score, whether or not they are originally the students of the department and whether or not they have a letter of reference, respectively. According to results, when the students are selected to the post-graduate education programs it is suggested that the weighting of the students' characteristics required is made by considering this order. In addition to this, it is thought that studying with different samples and different scaling methods provide important

  13. Mathematical epidemiology

    CERN Document Server

    Driessche, Pauline; Wu, Jianhong


    Based on lecture notes of two summer schools with a mixed audience from mathematical sciences, epidemiology and public health, this volume offers a comprehensive introduction to basic ideas and techniques in modeling infectious diseases, for the comparison of strategies to plan for an anticipated epidemic or pandemic, and to deal with a disease outbreak in real time. It covers detailed case studies for diseases including pandemic influenza, West Nile virus, and childhood diseases. Models for other diseases including Severe Acute Respiratory Syndrome, fox rabies, and sexually transmitted infections are included as applications. Its chapters are coherent and complementary independent units. In order to accustom students to look at the current literature and to experience different perspectives, no attempt has been made to achieve united writing style or unified notation. Notes on some mathematical background (calculus, matrix algebra, differential equations, and probability) have been prepared and may be downlo...

  14. Epigenetic epidemiology of cancer. (United States)

    Barrow, Timothy M; Michels, Karin B


    Epigenetic epidemiology includes the study of variation in epigenetic traits and the risk of disease in populations. Its application to the field of cancer has provided insight into how lifestyle and environmental factors influence the epigenome and how epigenetic events may be involved in carcinogenesis. Furthermore, it has the potential to bring benefit to patients through the identification of diagnostic markers that enable the early detection of disease and prognostic markers that can inform upon appropriate treatment strategies. However, there are a number of challenges associated with the conduct of such studies, and with the identification of biomarkers that can be applied to the clinical setting. In this review, we delineate the challenges faced in the design of epigenetic epidemiology studies in cancer, including the suitability of blood as a surrogate tissue and the capture of genome-wide DNA methylation. We describe how epigenetic epidemiology has brought insight into risk factors associated with lung, breast, colorectal and bladder cancer and review relevant research. We discuss recent findings on the identification of epigenetic diagnostic and prognostic biomarkers for these cancers.

  15. ‘Speed advising’ for medical students applying to residency programs: an efficient supplement to traditional advising

    Directory of Open Access Journals (Sweden)

    Jillian L. McGrath


    Full Text Available Background: Over time, Residency Match dynamics fluctuate with some specialties experiencing increases in medical student popularity. Academic departments with limited resources must devise methods for coping with increased demand for their specialty. Students perceive traditional programs on Match mechanics as inadequate. Subsequently, faculty are confronted with demands for more personal attention from more students. Objectives: We developed a strategy for providing specialty-specific residency match advising to large numbers of students. Methods: The ‘speed-advising’ session (SAS was developed to address the common questions and concerns that medical students pose during the Match process and to provide advisees with a breadth of faculty perspectives. Two SASs were offered over a 2-week period. After the sessions, students and faculty were surveyed regarding their experience. Results: Twenty-six students pursued our specialty in the 2015 Match (26 of 234, 11.1%. Twenty-three (89% participated in the SAS. Seventy-four percent of students (17 of 23 and all faculty completed the post-session survey. Students found the SAS to be informative, helpful and an efficient use of time. Common discussion topics included: career goals, to which programs and how many to apply, and how academic record impacts their likelihood of matching in our specialty. Students would have preferred more time with each faculty; however, most (77% conceded that their questions were adequately answered. Faculty-favored speed advising over traditional advising (86%, primarily due to estimated time savings of 7.3 h per faculty member. Conclusions: In preparing students for the Match, specialty-specific speed advising offers an efficient supplement to traditional advising.

  16. ‘Speed advising’ for medical students applying to residency programs: an efficient supplement to traditional advising (United States)

    McGrath, Jillian L.; Bischof, Jason J.; Greenberger, Sarah; Bachmann, Daniel J.; Way, David P.; Gorgas, Diane L.; Kman, Nicholas E.


    Background Over time, Residency Match dynamics fluctuate with some specialties experiencing increases in medical student popularity. Academic departments with limited resources must devise methods for coping with increased demand for their specialty. Students perceive traditional programs on Match mechanics as inadequate. Subsequently, faculty are confronted with demands for more personal attention from more students. Objectives We developed a strategy for providing specialty-specific residency match advising to large numbers of students. Methods The ‘speed-advising’ session (SAS) was developed to address the common questions and concerns that medical students pose during the Match process and to provide advisees with a breadth of faculty perspectives. Two SASs were offered over a 2-week period. After the sessions, students and faculty were surveyed regarding their experience. Results Twenty-six students pursued our specialty in the 2015 Match (26 of 234, 11.1%). Twenty-three (89%) participated in the SAS. Seventy-four percent of students (17 of 23) and all faculty completed the post-session survey. Students found the SAS to be informative, helpful and an efficient use of time. Common discussion topics included: career goals, to which programs and how many to apply, and how academic record impacts their likelihood of matching in our specialty. Students would have preferred more time with each faculty; however, most (77%) conceded that their questions were adequately answered. Faculty-favored speed advising over traditional advising (86%), primarily due to estimated time savings of 7.3 h per faculty member. Conclusions In preparing students for the Match, specialty-specific speed advising offers an efficient supplement to traditional advising. PMID:27056564

  17. Gene-Environment Research and Cancer Epidemiology (United States)

    The Epidemiology and Genomics Research Program supports extramural research that investigates both genetic and environmental factors that may contribute to the etiology of cancer and/or impact cancer outcomes.

  18. Q&A: Muin Khoury on cancer epidemiology. (United States)

    Khoury, Muin J; Rose, Suzanne


    Muin J. Khoury, MD, PhD, director of the Centers for Disease Control and Prevention's Office of Public Health Genomics and head of the National Cancer Institute's Epidemiology and Genomics Research Program in the Division of Cancer Control and Population Sciences, talks about challenges and opportunities in cancer epidemiology research and efforts in the epidemiology community to transform the field.

  19. Education in epidemiology: "The Times They Are a-Changin'". (United States)

    Samet, Jonathan M; Savitz, David A


    "The Changing Face of Epidemiology" is a series of symposia sponsored by Epidemiology for the purpose of addressing topical issues that cut across specialty areas. We comment here on 3 papers presented last summer at a symposium ("Education in Epidemiology: Changing needs for changing times") at the 2007 meeting of the Society for Epidemiologic Research. These papers address current challenges in training epidemiologists, including the rise of molecular epidemiology, the ongoing need to redefine core epidemiologic methods and develop optimum approaches, and the increasing difficulty of assuring competency in primary data collection. We offer suggestions for educational programs and professional organizations on approaching these ongoing challenges.

  20. [Eco-epidemiology: towards epidemiology of complexity]. (United States)

    Bizouarn, Philippe


    In order to solve public health problems posed by the epidemiology of risk factors centered on the individual and neglecting the causal processes linking the risk factors with the health outcomes, Mervyn Susser proposed a multilevel epidemiology called eco-epidemiology, addressing the interdependence of individuals and their connection with molecular, individual, societal, environmental levels of organization participating in the causal disease processes. The aim of this epidemiology is to integrate more than a level of organization in design, analysis and interpretation of health problems. After presenting the main criticisms of risk-factor epidemiology focused on the individual, we will try to show how eco-epidemiology and its development could help to understand the need for a broader and integrative epidemiology, in which studies designed to identify risk factors would be balanced by studies designed to answer other questions equally vital to public health.

  1. Existing Whole-House Solutions Case Study: Applying Best Practices to Florida Local Government Retrofit Programs - Central Florida

    Energy Technology Data Exchange (ETDEWEB)



    In some communities, local government and non-profit entities have funds to purchase and renovate distressed, foreclosed homes for resale in the affordable housing market. Numerous opportunities to improve whole house energy efficiency are inherent in these comprehensive renovations. BA-PIRC worked together in a multiyear field study making recommendations in individual homes, meanwhile compiling improvement costs, projected energy savings, practical challenges, and labor force factors surrounding common energy-related renovation measures. The field study, Phase 1 of this research, resulted in a set of best practices appropriate to the current labor pool and market conditions in central Florida to achieve projected annual energy savings of 15%-30% and higher. This case study describes Phase 2 of the work where researchers worked with a local government partner to implement and refine the "current best practices". A simulation study was conducted to characterize savings potential under three sets of conditions representing varying replacement needs for energy-related equipment and envelope components. The three scenarios apply readily to the general remodeling industry as for renovation of foreclosed homes for the affordable housing market. The new local government partner, the City of Melbourne, implemented the best practices in a community-scale renovation program that included ten homes in 2012.

  2. Exploring Flexible and Multidisciplinary Approaches to Applied Science Research Project Assessments: Case Studies from the NASA DEVELOP National Program (United States)

    Crepps, G.; Childs-Gleason, L. M.; Favors, J. E.; Ross, K. W.; Rogers, L.; Allsbrook, K. N.; Ruiz, M. L.


    Within the NASA DEVELOP National Program, teams conduct rapid prototype and feasibility projects, applying NASA Earth Observations to a broad range of problems in diverse focus areas, including water resources, agriculture, disaster management, and ecological forecasting, with the goal of assisting partner organizations in their decision making processes. Projects vary in scope, design, and satellite data utilized. As a result, there is no "fixed" set of indicators that encompasses all relevant impacts of all projects. Rather, a flexible toolkit of both shared indicators and individualized approaches is needed to capture the diverse outcomes of these projects, while still allowing for comparability of the projects. This has been done through the creation of pre- and post-project partner assessments that capture partner needs, capabilities, and expectations. This provides both baseline data and an overview of project impacts on partners. Selected projects are then individually assessed in greater detail through partner follow-ups and research into the quantification of project impacts utilizing interdisciplinary approaches to fit each project. This process is discussed through three examples of project impact assessments that draw from varied discipline approaches including cost benefit analysis and ecosystem services.

  3. Coccidioidomycosis: epidemiology

    Directory of Open Access Journals (Sweden)

    Brown J


    Full Text Available Jennifer Brown,1 Kaitlin Benedict,2 Benjamin J Park,2 George R Thompson III1,31Department of Internal Medicine, Division of Infectious Diseases, University of California, Davis Medical Center, Sacramento, CA, USA; 2Mycotic Diseases Branch, Division of Foodborne, Waterborne, and Environmental Diseases, US Centers for Disease Control and Prevention, Atlanta, GA, USA; 3Department of Medical Microbiology and Immunology, One Shields Avenue, Tupper Hall, Coccidioidomycosis Serology Laboratory, University of California, Davis, CA, USAAbstract: Coccidioidomycosis consists of a spectrum of disease, ranging from a mild, self-limited, febrile illness to severe, life-threatening infection. It is caused by the soil-dwelling fungi, Coccidioides immitis and C. posadasii, which are present in diverse endemic areas. Climate changes and environmental factors affect the Coccidioides lifecycle and influence infection rates. The incidence of coccidioidomycosis has risen substantially over the past two decades. The vast majority of Coccidioides infections occur in the endemic zones, such as California, Arizona, Mexico, and Central America. Infections occurring outside those zones appear to be increasingly common, and pose unique clinical and public health challenges. It has long been known that elderly persons, pregnant women, and members of certain ethnic groups are at risk for severe or disseminated coccidioidomycosis. In recent years, it has become evident that persons with immunodeficiency diseases, diabetics, transplant recipients, and prisoners are also particularly vulnerable.Keywords: coccidioidomycosis, Coccidioides, epidemiology, incidence, risk factors, geography

  4. Epidemiology of Lyme Disease

    Directory of Open Access Journals (Sweden)

    Dennis J White


    Full Text Available Investigation of the epidemiology of Lyme disease depends upon information generated from several sources. Human disease surveillance can be conducted by both passive and active means involving physicians, public health agencies and laboratories. Passive and active tick surveillance programs can document the extent of tick-borne activity, identify the geographic range of potential vector species, and determine the relative risk of exposure to Lyme disease in specific areas. Standardized laboratory services can play an important role in providing data. Epidemiologists can gain a better understanding of Lyme disease through the collection of data from such programs. The interpretation of data and provision of information to the medical and general communities are important functions of public health agencies.

  5. Examining the Effect of Social Values Education Program Being Applied to Nursery School Students upon Acquiring Social Skills (United States)

    Sapsaglam, Özkan; Ömeroglu, Esra


    This study was conducted in an attempt to develop Social Values Education Program aimed at nursery school students and examine the effect of Social Values Education Program upon the social skill acquisition of nursery school students. The effect of the education program that was developed within the scope of the study upon the social skill…

  6. Evaluation of the Association between Persistent Organic Pollutants (POPs)and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review (United States)

    Background: Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health.Objective: We assessed the epidemiologic litera...

  7. Trichinosis: Epidemiology in Thailand

    Institute of Scientific and Technical Information of China (English)

    Natthawut Kaewpitoon; Soraya Jatesadapattaya Kaewpitoon; Chutikan Philasri; Ratana Leksomboon; Chanvit Maneenin; Samaporn Sirilaph; Prasit Pengsaa


    Trichinosis is one of the most common food-borne parasitic zoonoses in Thailand and many outbreaks are reported each year. This paper reviews the history, species,and epidemiology of the disease and food habits of the people with an emphasis on the north, northeast, central and south regions of Thailand. The earliest record of trichinosis in Thailand was in 1962 in the Mae Sariang District, Mae Hong Son Province. Since then, about 130 outbreaks have been reported involving 7392 patients and 97 deaths (1962-2005). The highest number of cases, 557, was recorded in 1983. The annual epidemiological surveillance reports of the Bureau of Epidemiology,Department of Disease Control, Ministry of Public Health,Thailand, show that trichinosis cases increased from 61 in 1997 to 351 in 1998.In contrast to these figures, the number of reported cases decreased to 16 in 1999 and 128 cases in 2000. There was no record of trichinosis in 2001, but then the figures for 2002, 2003 and 2004 were 289, 126 and 212 respectively. The infected patients were mostly in the 35-44 years age group and the disease occurred more frequently in men than women at a ratio of 1.7-2.0:1. There were 84 reported cases of trichinosis in Chiang Rai, Nan, Chiang Mai, Si Sa ket,Nakhon Phanom, Kalasin, Nakhon Ratchasima, Nakhon Nayok, Nakhon Pathom and Surat Thani, provinces located in different parts of Thailand in 2005. The outbreaks were more common in the northern areas, especially in rural areas where people ate raw or under-cooked pork and/or wild animals. This indicates the need for health education programs to prevent and control trichinosis as soon as possible in the high-risk areas.

  8. 20 CFR 670.965 - What procedures apply to disclosure of information about Job Corps students and program activities? (United States)


    ... information about Job Corps students and program activities? 670.965 Section 670.965 Employees' Benefits... information about Job Corps students and program activities? (a) The Secretary develops procedures to respond to requests for information or records or other necessary disclosures pertaining to students. (b)...

  9. 76 FR 66849 - Applying for Free and Reduced Price Meals in the National School Lunch Program and School... (United States)


    ... Richard B. Russell National School Lunch Act (NSLA) (42 U.S.C. 1751 et seq.) and the Child Nutrition Act... / Friday, October 28, 2011 / Rules and Regulations#0;#0; ] DEPARTMENT OF AGRICULTURE Food and Nutrition... the National School Lunch Program and School Breakfast Program and for Benefits in the Special...

  10. Bringing Evidence-Based Sexual Health Programs to Adolescents in Black Churches: Applying Knowledge from Systematic Adaptation Frameworks (United States)

    Weeks, Fiona H.; Powell, Terrinieka W.; Illangasekare, Samantha; Rice, Eric; Wilson, James; Hickman, Debra; Blum, Robert W.


    Previous studies have documented Black churches' receptivity to implementing adolescent sexual health programs within their congregations. Some authors have argued for new sexual health programs to be designed specifically for churches, similar to the development of school- and community-based interventions. However, strategies and curricula used…

  11. [Epidemiology of tuberculosis]. (United States)

    Mjid, M; Cherif, J; Ben Salah, N; Toujani, S; Ouahchi, Y; Zakhama, H; Louzir, B; Mehiri-Ben Rhouma, N; Beji, M


    Tuberculosis is a contagious disease caused by Mycobacterium tuberculosis. It represents, according to World Health Organization (WHO), one of the most leading causes of death worldwide. With nearly 8 million new cases each year and more than 1 million deaths per year, tuberculosis is still a public health problem. Despite of the decrease in incidence, morbidity and mortality remain important partially due to co-infection with human immunodeficiency virus and emergence of resistant bacilli. All WHO regions are not uniformly affected by TB. Africa's region has the highest rates of morbidity and mortality. The epidemiological situation is also worrying in Eastern European countries where the proportion of drug-resistant tuberculosis is increasing. These regional disparities emphasize to develop screening, diagnosis and monitoring to the most vulnerable populations. In this context, the Stop TB program, developed by the WHO and its partner's, aims to reduce the burden of disease in accordance with the global targets set for 2015.

  12. Ehrlichiosis: Statistics and Epidemiology (United States)

    ... a tick Diseases transmitted by ticks Statistics and Epidemiology Recommend on Facebook Tweet Share Compartir On this ... Holman RC, McQuiston JH, Krebs JW, Swerdlow DL. Epidemiology of human ehrlichiosis and anaplasmosis in the United ...

  13. Anaplasmosis: Statistics and Epidemiology (United States)

    ... a tick Diseases transmitted by ticks Statistics and Epidemiology Recommend on Facebook Tweet Share Compartir On this ... Holman RC, McQuiston JH, Krebs JW, Swerdlow DL. Epidemiology of human ehrlichiosis and anaplasmosis in the United ...

  14. International Lymphoma Epidemiology Consortium (United States)

    The InterLymph Consortium, or formally the International Consortium of Investigators Working on Non-Hodgkin's Lymphoma Epidemiologic Studies, is an open scientific forum for epidemiologic research in non-Hodgkin's lymphoma.

  15. [Dermato-epidemiology]. (United States)

    Apfelbacher, C J; Diepgen, T L; Weisshaar, E


    Dermato-epidemiology is an important scientific discipline which investigates skin diseases using epidemiological methods. Epidemiology is the science of the distribution and determinants of disease in specified populations. We describe fundamental terms of dermato-epidemiology (measures of disease occurrence, measures of risk), different study types (observational studies, interventional studies), the selection of statistical tests, bias and confounding as well as the principles of evidence-based dermatology, and give illustrative examples.

  16. The Office Guidelines Applied to Practice program improves secondary prevention of heart disease in Federally Qualified Healthcare Centers

    Directory of Open Access Journals (Sweden)

    Adesuwa Olomu


    Office-GAP resulted in increased use of guideline-based medications for secondary CVD prevention in underserved populations. The Office-GAP program could serve as a model for implementing guideline-based care for other chronic diseases.

  17. Airline return-on-investment model for technology evaluation. [computer program to measure economic value of advanced technology applied to passenger aircraft (United States)


    This report presents the derivation, description, and operating instructions for a computer program (TEKVAL) which measures the economic value of advanced technology features applied to long range commercial passenger aircraft. The program consists of three modules; and airplane sizing routine, a direct operating cost routine, and an airline return-on-investment routine. These modules are linked such that they may be operated sequentially or individually, with one routine generating the input for the next or with the option of externally specifying the input for either of the economic routines. A very simple airplane sizing technique was previously developed, based on the Brequet range equation. For this program, that sizing technique has been greatly expanded and combined with the formerly separate DOC and ROI programs to produce TEKVAL.

  18. Applying what works: a systematic search of the transfer and implementation of promising Indigenous Australian health services and programs

    Directory of Open Access Journals (Sweden)

    McCalman Janya


    Full Text Available Abstract Background The transfer and implementation of acceptable and effective health services, programs and innovations across settings provides an important and potentially cost-effective strategy for reducing Indigenous Australians' high burden of disease. This study reports a systematic review of Indigenous health services, programs and innovations to examine the extent to which studies considered processes of transfer and implementation within and across Indigenous communities and healthcare settings. Methods Medline, Informit, Infotrac, Blackwells Publishing, Proquest, Taylor and Francis, JStor, and the Indigenous HealthInfoNet were searched using terms: Aborigin* OR Indigen* OR Torres AND health AND service OR program* OR intervention AND Australia to locate publications from 1992–2011. The reference lists of 19 reviews were also checked. Data from peer reviewed journals, reports, and websites were included. The 95% confidence intervals (95% CI for proportions that referred to and focussed on transfer were calculated as exact binomial confidence intervals. Test comparisons between proportions were calculated using Fisher's exact test with an alpha level of 5%. Results Of 1311 publications identified, 119 (9.1%; 95% CI: 7.6% - 10.8% referred to the transfer and implementation of Indigenous Australian health services or programs, but only 21 studies (1.6%; 95% CI: 1.0% - 2.4% actually focused on transfer and implementation. Of the 119 transfer studies, 37 (31.1%; 95% CI: 22.9 - 40.2% evaluated the impact of a service or program, 28 (23.5%; 95% CI: 16.2% - 32.2% reported only process measures and 54 were descriptive. Of the 37 impact evaluation studies, 28 (75.7%; 95% CI: 58.8% - 88.2% appeared in peer reviewed journals but none included experimental designs. Conclusion While services and programs are being transferred and implemented, few studies focus on the process by which this occurred or the effectiveness of the service or program

  19. 2005 Mississippi Curriculum Framework: Secondary Horticulture. (Program CIP: 01.0601 - Applied Horticulture/Horticultural Operations, General) (United States)

    Research and Curriculum Unit, 2005


    Secondary vocational-technical education programs in Mississippi are faced with many challenges resulting from sweeping educational reforms at the national and state levels. Schools and teachers are increasingly being held accountable for providing true learning activities to every student in the classroom. This accountability is measured through…

  20. 31 CFR 205.25 - How does this part apply to certain Federal assistance programs or funds? (United States)


    ... Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY FINANCIAL MANAGEMENT SERVICE RULES AND PROCEDURES FOR EFFICIENT FEDERAL-STATE FUNDS TRANSFERS Rules Applicable to Federal... undistributed collections must be treated as Federal assistance program income under 45 CFR 304.50(b) and is...

  1. For the Love of Statistics: Appreciating and Learning to Apply Experimental Analysis and Statistics through Computer Programming Activities (United States)

    Mascaró, Maite; Sacristán, Ana Isabel; Rufino, Marta M.


    For the past 4 years, we have been involved in a project that aims to enhance the teaching and learning of experimental analysis and statistics, of environmental and biological sciences students, through computational programming activities (using R code). In this project, through an iterative design, we have developed sequences of R-code-based…

  2. A new 2D segmentation method based on dynamic programming applied to computer aided detection in mammography. (United States)

    Timp, Sheila; Karssemeijer, Nico


    Mass segmentation plays a crucial role in computer-aided diagnosis (CAD) systems for classification of suspicious regions as normal, benign, or malignant. In this article we present a robust and automated segmentation technique--based on dynamic programming--to segment mass lesions from surrounding tissue. In addition, we propose an efficient algorithm to guarantee resulting contours to be closed. The segmentation method based on dynamic programming was quantitatively compared with two other automated segmentation methods (region growing and the discrete contour model) on a dataset of 1210 masses. For each mass an overlap criterion was calculated to determine the similarity with manual segmentation. The mean overlap percentage for dynamic programming was 0.69, for the other two methods 0.60 and 0.59, respectively. The difference in overlap percentage was statistically significant. To study the influence of the segmentation method on the performance of a CAD system two additional experiments were carried out. The first experiment studied the detection performance of the CAD system for the different segmentation methods. Free-response receiver operating characteristics analysis showed that the detection performance was nearly identical for the three segmentation methods. In the second experiment the ability of the classifier to discriminate between malignant and benign lesions was studied. For region based evaluation the area Az under the receiver operating characteristics curve was 0.74 for dynamic programming, 0.72 for the discrete contour model, and 0.67 for region growing. The difference in Az values obtained by the dynamic programming method and region growing was statistically significant. The differences between other methods were not significant.

  3. 40 CFR 1045.605 - What provisions apply to engines already certified under the motor vehicle or Large SI programs? (United States)


    ... engines under 40 CFR parts 85 and 86 or part 1048 for the appropriate model year. If you comply with all the provisions of this section, we consider the certificate issued under 40 CFR part 86 or 1048 for... meet all the applicable requirements from 40 CFR parts 85 and 86, or part 1048. This applies to...


    NARCIS (Netherlands)



    Stable lyophilized ethylenediaminetetra-acetic acid (EDTA)-blood haemolysates were applied in an external quality assurance programme (SKZL, The Netherlands) for glycohaemoglobin assays in 101 laboratories using 12 methods. The mean intralaboratory day-to-day coefficient of variation (CV), calculate

  5. Applying Learner-Centered Principles to Teaching Human Behavior in the Social Environment in a Baccalaureate Program (United States)

    Karolich, Robert; Ford, Janet


    Changes in the demographics of American undergraduate students must be addressed by changes in delivery of the curriculum. The learner-centered approach to education helps to recognize and integrate student diversity with class exercises and assignments designed to help students meet course learning outcomes. This article applies the American…

  6. Applying Various Methods of Communicating Science for Community Decision-Making and Public Awareness: A NASA DEVELOP National Program Case Study (United States)

    Miller, T. N.; Brumbaugh, E. J.; Barker, M.; Ly, V.; Schick, R.; Rogers, L.


    The NASA DEVELOP National Program conducts over eighty Earth science projects every year. Each project applies NASA Earth observations to impact decision-making related to a local or regional community concern. Small, interdisciplinary teams create a methodology to address the specific issue, and then pass on the results to partner organizations, as well as providing them with instruction to continue using remote sensing for future decisions. Many different methods are used by individual teams, and the program as a whole, to communicate results and research accomplishments to decision-makers, stakeholders, alumni, and the general public. These methods vary in scope from formal publications to more informal venues, such as social media. This presentation will highlight the communication techniques used by the DEVELOP program. Audiences, strategies, and outlets will be discussed, including a newsletter, microjournal, video contest, and several others.

  7. Applying the Context, Input, Process, Product Evaluation Model for Evaluation, Research, and Redesign of an Online Master’s Program

    Directory of Open Access Journals (Sweden)

    Hatice Sancar Tokmak


    Full Text Available This study aimed to evaluate and redesign an online master’s degree program consisting of 12 courses from the informatics field using a context, input, process, product (CIPP evaluation model. Research conducted during the redesign of the online program followed a mixed methodology in which data was collected through a CIPP survey, focus-group interview, and open-ended questionnaire. An initial CIPP survey sent to students, which had a response rate of approximately 60%, indicated that the Fuzzy Logic course did not fully meet the needs of students. Based on these findings, the program managers decided to improve this course, and a focus group was organized with the students of the Fuzzy Logic course in order to obtain more information to help in redesigning the course. Accordingly, the course was redesigned to include more examples and visuals, including videos; student-instructor interaction was increased through face-to-face meetings; and extra meetings were arranged before exams so that additional examples could be presented for problem-solving to satisfy students about assessment procedures. Lastly, the modifications to the Fuzzy Logic course were implemented, and the students in the course were sent an open-ended form asking them what they thought about the modifications. The results indicated that most students were pleased with the new version of the course.

  8. Web Application Development by Applying the MVC and Table Data Gateway in the Annual Program Budget Management System

    Directory of Open Access Journals (Sweden)

    A. Medina-Santiago


    Full Text Available This paper is the result of the development of the Web application to register the Annual Work Program, in which goals and actions are assigned the financial resources to manage the annual work program identified. In this paper, we have identified five types of users: the first is the Administrator, in charge of monitoring the goals programmed in the period, as well as the resource assigned to reach those goals; the second corresponds to the purchasing department who is in charge of contacting the supplier and at the same time inform financial and warehouse of the acquisition through the system; the third corresponds to a warehouse in charge of validating the material and generate entry / exit official vouchers and send the purchase order to financiers; the fourth user corresponds to financial, this will identify through the system that all the procedure is completed to make the payment; and finally, the fifth user make up the set of all remaining departments. Finally, the system presents flexibility in case it is necessary to go adding departments.

  9. Linking healthcare associated norovirus outbreaks: a molecular epidemiologic method for investigating transmission

    Directory of Open Access Journals (Sweden)

    Andrews Nick


    Full Text Available Abstract Background Noroviruses are highly infectious pathogens that cause gastroenteritis in the community and in semi-closed institutions such as hospitals. During outbreaks, multiple units within a hospital are often affected, and a major question for control programs is: are the affected units part of the same outbreak or are they unrelated transmission events? In practice, investigators often assume a transmission link based on epidemiological observations, rather than a systematic approach to tracing transmission. Here, we present a combined molecular and statistical method for assessing: 1 whether observed clusters provide evidence of local transmission and 2 the probability that anecdotally|linked outbreaks truly shared a transmission event. Methods 76 healthcare associated outbreaks were observed in an active and prospective surveillance scheme of 15 hospitals in the county of Avon, England from April 2002 to March 2003. Viral RNA from 64 out of 76 specimens from distinct outbreaks was amplified by reverse transcription-PCR and was sequenced in the polymerase (ORF 1 and capsid (ORF 2 regions. The genetic diversity, at the nucleotide level, was analysed in relation to the epidemiological patterns. Results Two out of four genetic and epidemiological clusters of outbreaks were unlikely to have occurred by chance alone, thus suggesting local transmission. There was anecdotal epidemiological evidence of a transmission link among 5 outbreaks pairs. By combining this epidemiological observation with viral sequence data, the evidence of a link remained convincing in 3 of these pairs. These results are sensitive to prior beliefs of the strength of epidemiological evidence especially when the outbreak strains are common in the background population. Conclusion The evidence suggests that transmission between hospitals units does occur. Using the proposed criteria, certain hypothesized transmission links between outbreaks were supported while

  10. Lessons from the epidemiological surveillance program, during the influenza A (H1N1 virus epidemic, in a reference university hospital of Southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Maria Luiza Moretti


    Full Text Available INTRODUCTION: The case definition of influenza-like illness (ILI is a powerful epidemiological tool during influenza epidemics. METHODS: A prospective cohort study was conducted to evaluate the impact of two definitions used as epidemiological tools, in adults and children, during the influenza A H1N1 epidemic. Patients were included if they had upper respiratory samples tested for influenza by real-time reverse transcriptase polymerase chain reaction during two periods, using the ILI definition (coughing + temperature > 38ºC in period 1, and the definition of severe acute respiratory infection (ARS (coughing + temperature > 38ºC and dyspnoea in period 2. RESULTS: The study included 366 adults and 147 children, covering 243 cases of ILI and 270 cases of ARS. Laboratory confirmed cases of influenza were higher in adults (50% than in children (21.6% ( p < 0.0001 and influenza infection was more prevalent in the ILI definition (53% than ARS (24.4% (p < 0.0001. Adults reported more chills and myalgia than children (p = 0.0001. Oseltamivir was administered in 58% and 46% of adults and children with influenza A H1N1, respectively. The influenza A H1N1 case fatality rate was 7% in adults and 8.3% in children. The mean time from onset of illness until antiviral administration was 4 days. CONCLUSIONS: The modification of ILI to ARS definition resulted in less accuracy in influenza diagnosis and did not improve the appropriate time and use of antiviral medication.

  11. Survey of different types of field epidemiology training programs in China%我国省市县现场流行病学培训项目现况调查

    Institute of Scientific and Technical Information of China (English)

    刘慧慧; 张丽杰; 施国庆; 裴迎新; 马会来; 曾光


    Objective To understand the current status,type,and effect of training programs conducted by Health Bureau and CDC in China.Methods One person of each province was selected from China field epidemiology training network and designated as contact person who was responsible for collecting information of field practical training lasting for at least 6 months for staff of public health emergency and infectious disease control in each province from October 2001 to October 2010.Questionnaire including basic condition,organization and management,training design,faculty condition,trainee condition and training outputs was designed and filled in by contact person.Results There were 35 training programs covering over 9 provinces in China.The first province and city FETP started in 2004,including Guangdong FETP,Zhejiang FETP,Hangzhou FETP,Ningbo FETP and Guizhou FETP.Thirty-five training programs had 355 mentors,22(6%)were CFETP graduates and 57 (16%)were local FETP graduates.All program funds were paid by local governments.The training programs included two parts,theoretical lectures and field practice,which occupying 10%-20% and 80%-90% of the whole training time,respectively.Among 6 evaluative items including emergency investigation,surveillance analysis,surveillance evaluation,planned investigation,investigation report and paper publication,most programs(50%-94%) had less than average one person per time.Conclusions Field epidemiology training program after several years of development in china achieves the certain scale.Some provincial programs are successful,but the effect and quality of training programs in different areas are uneven.We suggest optimizing of field epidemiology training resources and further expanding China field epidemiology training network.%目的 了解我国省、市、县开展的现场流行病学培训项目(field epidemiology trainingprograms,FETP)现状、类型、培训效果及存在问题.方法 在中国现场流行病

  12. Complementary Core Competencies for Master of Science in Epidemiology Students


    Nayyereh Aminisani; Seyed Morteza Shamshirgaran; Homayoun Sadeghi Bazargani; Mohamad Asghari Jafarabadi; Saeed Dastgiri; Parivin Sarbakhsh; Abdorasoul Safaiyan; Asghar Mohammadpoorasl


    Introduction: Competency-based education has been recommended in training and education of public health to reduce the gap between traditional teaching and the competencies required in practice. Epidemiology as a fundamental of public health science has come to attention. The aim of this study was to introduce a complementary core competency program for Master of Science (MSc) in epidemiology students in Iran. Methods: A workgroup in the department of statistics and epidemiology of Tabriz Uni...

  13. Gulf Coast geopressured-geothermal program summary report compilation. Volume 3: Applied and direct uses, resource feasibility, economics

    Energy Technology Data Exchange (ETDEWEB)

    John, C.J.; Maciasz, G.; Harder, B.J.


    The US Department of Energy established a geopressured-geothermal energy program in the mid 1970`s as one response to America`s need to develop alternate energy resources in view of the increasing dependence on imported fossil fuel energy. This program continued for 17 years and approximately two hundred million dollars were expended for various types of research and well testing to thoroughly investigate this alternative energy source. This volume describes the following studies: Geopressured-geothermal hybrid cycle power plant: design, testing, and operation summary; Feasibility of hydraulic energy recovery from geopressured-geothermal resources: economic analysis of the Pelton turbine; Brine production as an exploration tool for water drive gas reservoirs; Study of supercritical Rankine cycles; Application of the geopressured-geothermal resource to pyrolytic conversion or decomposition/detoxification processes; Conclusions on wet air oxidation, pyrolytic conversion, decomposition/detoxification process; Co-location of medium to heavy oil reservoirs with geopressured-geothermal resources and the feasibility of oil recovery using geopressured-geothermal fluids; Economic analysis; Application of geopressured-geothermal resources to direct uses; Industrial consortium for the utilization of the geopressured-geothermal resource; Power generation; Industrial desalination, gas use and sales, pollutant removal, thermal EOR, sulfur frasching, oil and natural gas pipelining, coal desulfurization and preparation, lumber and concrete products kilning; Agriculture and aquaculture applications; Paper and cane sugar industries; Chemical processing; Environmental considerations for geopressured-geothermal development. 27 figs., 25 tabs.

  14. Hype, harmony and human factors: applying user-centered design to achieve sustainable telehealth program adoption and growth. (United States)

    Rossos, P G; St-Cyr, O; Purdy, B; Toenjes, C; Masino, C; Chmelnitsky, D


    Despite decades of international experience with the use of information and communication technologies in healthcare delivery, widespread telehealth adoption remains limited and progress slow. Escalating health system challenges related to access, cost and quality currently coincide with rapid advancement of affordable and reliable internet based communication technologies creating unprecedented opportunities and incentives for telehealth. In this paper, we will describe how Human Factors Engineering (HFE) and user-centric elements have been incorporated into the establishment of telehealth within a large academic medical center to increase acceptance and sustainability. Through examples and lessons learned we wish to increase awareness of HFE and its importance in the successful implementation, innovation and growth of telehealth programs.

  15. Applying the system engineering approach to devise a master’s degree program in space technology in developing countries (United States)

    Jazebizadeh, Hooman; Tabeshian, Maryam; Taheran Vernoosfaderani, Mahsa


    Although more than half a century is passed since space technology was first developed, developing countries are just beginning to enter the arena, focusing mainly on educating professionals. Space technology by itself is an interdisciplinary science, is costly, and developing at a fast pace. Moreover, a fruitful education system needs to remain dynamic if the quality of education is the main concern, making it a complicated system. This paper makes use of the System Engineering Approach and the experiences of developed countries in this area while incorporating the needs of the developing countries to devise a comprehensive program in space engineering at the Master's level. The needs of the developing countries as regards space technology education may broadly be put into two categories: to raise their knowledge of space technology which requires hard work and teamwork skills, and to transfer and domesticate space technology while minimizing the costs and maximizing its effectiveness. The requirements of such space education system, which include research facilities, courses, and student projects are then defined using a model drawn from the space education systems in universities in North America and Europe that has been modified to include the above-mentioned needs. Three design concepts have been considered and synthesized through functional analysis. The first one is Modular and Detail Study which helps students specialize in a particular area in space technology. Second is referred to as Integrated and Interdisciplinary Study which focuses on understanding and development of space systems. Finally, the third concept which has been chosen for the purpose of this study, is a combination of the other two, categorizing the required curriculum into seven modules, setting aside space applications. This helps students to not only specialize in one of these modules but also to get hands-on experience in a real space project through participation in summer group

  16. The next generation of large-scale epidemiologic research: implications for training cancer epidemiologists. (United States)

    Spitz, Margaret R; Lam, Tram Kim; Schully, Sheri D; Khoury, Muin J


    There is expanding consensus on the need to modernize the training of cancer epidemiologists to accommodate rapidly emerging technological advancements and the digital age, which are transforming the practice of cancer epidemiology. There is also a growing imperative to extend cancer epidemiology research that is etiological to that which is applied and has the potential to affect individual and public health. Medical schools and schools of public health are recognizing the need to develop such integrated programs; however, we lack the data to estimate how many current training programs are effectively equipping epidemiology students with the knowledge and tools to design, conduct, and analyze these increasingly complex studies. There is also a need to develop new mentoring approaches to account for the transdisciplinary team-science environment that now prevails. With increased dialogue among schools of public health, medical schools, and cancer centers, revised competencies and training programs at predoctoral, doctoral, and postdoctoral levels must be developed. Continuous collection of data on the impact and outcomes of such programs is also recommended.

  17. Modelling the Processes of Maximizing Hotel Revenues, Based on Applying the Linear Programming and the Network Flows

    Directory of Open Access Journals (Sweden)

    Margareta RACOVITA


    Full Text Available This work proposes to solve a problem related to maximizing hotels’ revenues through two methods established in operational research domain. In the first part of the paper, the approach involves formulating the objective function and problem’s constraints, as well as the expansion of the model, taking into consideration clients’ preferences and the opportunities of group reservations. In the second part of the paper, the problem is solved with the help of network flows model, which allows optimum allocation of the rooms in real time. At the end of the paper, there are highlighted the advantages of applying those two mathematic methods within the strategies of performances development within hotel industry.

  18. A molecular epidemiologic study of thalassemia using newborns' cord blood in a multiracial Asian population in Singapore: results and recommendations for a population screening program. (United States)

    Kham, S K; Yin, Shirley Kham Kow; Quah, Thuan Chong; Loong, Ai Mei; Tan, Poh Lin; Fraser, Angus; Chong, S S; Chuan, Samuel Chong Siong; Yeoh, A E; Eng-Juh, Allen Yeoh


    DNA technology provides a new avenue to perform neonatal screening tests for single-gene diseases in populations of high frequency. Thalassemia is one of the high-frequency single-gene disorders affecting Singapore and many countries in the malaria belt. The authors explored the feasibility of using PCR-based diagnostic screening on 1,116 unselected sequential cord blood samples for neonatal screening. The cord blood samples were screened for the most common reported alpha- and beta-thalassemia mutations in each ethnic group (Chinese, Malays, and Indians) in a multiracial population. The carrier frequency for alpha-thalassemia mutations was about 6.4% in the Chinese (alpha deletions = 3.9%, alpha deletions = 2.5%), 4.8% in Malays, and 5.2% in Indians. Only alpha deletions were observed in the Chinese. The carrier frequency for beta-thalassemia mutations was 2.7% in the Chinese, 6.3% in Malays, and 0.7% in Indians. Extrapolating to the population distribution of Singapore, the authors found a higher overall expected carrier frequency for alpha- and beta-thalassemia mutations of 9% compared with a previous population study of 6% by phenotype. The highly accurate results make this molecular epidemiologic screening an ideal method to screen for and prevent severe thalassemia in high-risk populations.

  19. [Epidemiology and public policies]. (United States)

    Barata, Rita Barradas


    The present essay deals with the relation between epidemiology and public policies, highlighting the epidemiology position in the public health field, analyzing the impact of public policies over epidemiological profile and contributions from epidemiology to the lay down, implementation and evaluation of public health policies. In the first title, the essay debates the links between the epidemiology and public health field, the social determinants and political action framework proposed by the WHO's Commission on Social Determinants of Health, and different approaches of health policies. In the second title the essay analyses the reduction of child stunting in Brazil as an example of public policies that impact epidemiological profile. The third title presents three strategic topics for the application of public health policies: reduction of social inequalities in health, health promotion and regulation of products and services that have impact over health. The fourth title discusses the possibilities and difficulties to combine the epidemiological knowledge in the lay down, implementation and evaluation of public policies and, finally, material examples of such relation between epidemiology and public policies are presented.

  20. ["The Use and Control of Stress". A program applied to workers of the IMSS. Instituto Mexicano del Seguro Social]. (United States)

    Maldonado-Islas, G; Mancera-Pérez, A A


    Stress, is considered to be a bodily response to both internal and environmental stimuli, is a live and unavoidable energy. It is important and necessary to learn to use it beneficially. In order to determine the utility of the educational program. "The use use and control of stress", a quasi-experimental study was conducted in 1993, in which 39 voluntary Zone I General Hospital (IMSS Tlaxcala State Delegation) workers were selected, based on stress levels over 3 points as found in an institutional validated to measure the stress level. Five groups were set up, and eight weekly educative interventions, composed of cognitive contents including stress, relaxation techniques, and techniques for living of 90 minutes each were attended by the members of these groups, utilizing groups dynamics. The results were analyzed in simple absolute and relative frequencies, as well as by Student's t tests. They show a reduction stress levels in 94.8% of the participants, which represents a 69.1% general gain, with p = < 0.005. The conclusion is that learning related with the use and control of stress is an alternative to improve the mental health of the individual and as concerns the work environment, to modify attitude of the IMSS worker.

  1. Data Processing and Programming Applied to an Environmental Radioactivity Laboratory; Desarrollo Informatico Aplicado a un Laboratorio de Radiactividad Ambiental

    Energy Technology Data Exchange (ETDEWEB)

    Trinidad, J.A.; Gasco, C.; Palacios, M.A.


    This report is the original research work presented for the attainment of the author master degree and its main objective has been the resolution -by means of friendly programming- of some of the observed problems in the environmental radioactivity laboratory belonging to the Department of Radiological Surveillance and Environmental Radioactivity from CIEMAT. The software has been developed in Visual Basic for applications in Excel files and it solves by macro orders three of the detected problems: a) calculation of characteristic limits for the measurements of the beta total and beta rest activity concentrations according to standards MARLAP, ISO and UNE and the comparison of the three results b) Pb-210 and Po-210 decontamination factor determination in the ultra-low level Am-241 analysis in air samples by alpha spectrometry and c) comparison of two analytical techniques for measuring Pb-210 in air ( direct-by gamma spectrometry- and indirect -by radiochemical separation and alpha spectrometry). The organization processes of the different excel files implied in the subroutines, calculations and required formulae are explained graphically for its comprehension. The advantage of using this kind of programmes is based on their versatility and the ease for obtaining data that lately are required by tables that can be modified as time goes by and the laboratory gets more data with the special applications for describing a method (Pb-210 decontamination factors for americium analysis in air) or comparing temporal series of Pb-210 data analysed by different methods (Pb-210 in air). (Author)

  2. Welcome to epidemiology and health. (United States)

    Choi, Bo Youl


    The Korean Society of Epidemiology publishes a scholarly journal titled 'Korean Journal of Epidemiology', which announces and discusses the results of epidemiological studies from the past 30 yr. Since its first publication in 1979, the journal has contributed to the advancement of epidemiology as well as the prevention and control of disease, and the promotion of health in Korea.In 2009, the editorial board has decided to publish the journal in English to contribute internationally, and change the journal's name. The new name of the journal is 'Epidemiology and Health'.The abstract and full text of articles will be published as an open access online journal, which will be posted onto the homepage ( in real time for anyone in the world to access free of charge. Our editorial policy is that 'Epidemiology and Health' is open to every researcher in fields related to epidemiology, regardless of membership, his or her major and nationality.Editorials, lectures, review papers, original articles, epidemic and case investigations, brief communications and letters will be published to generate active discussion through the journal along with the publication of the papers.'Epidemiology and Health' welcomes articles from various fields of epidemiology, such as 1) infectious diseases epidemiology, 2) chronic diseases epidemiology, 3) nutritional epidemiology, 4) clinical epidemiology, 5) pharmacoepidemiology, 6) genetic or molecular epidemiology, 7) social epidemiology, 8) environmental or occupational epidemiology, 9) epidemiological methods and biostatistics, 10) disease prevention and control, 11) health promotion and, 12) all other fields related to epidemiology.

  3. Incidence and trends of cardiovascular mortality after common cancers in young adults:Analysis of surveillance, epidemiology and end-results program

    Institute of Scientific and Technical Information of China (English)

    Sadeer G Al-Kindi; Guilherme H Oliveira


    AIM: To describe the incidence of cardiovascular mortality(CVM) in survivors of major cancers and identify its trends over the past two decades. METHODS: We used the surveillance, epidemiology and end-results 19 registry to identify young adults(20-49 years), diagnosed with the following major primary cancers: Lung, breast, liver/intrahepatic bile duct, pancreas, prostate, colorectal, and ovarian from 1990 through 2012 and identified the cumulative incidence of CVM after adjusting for confounding factors. RESULTS: We identified a total of 301923 cancers(breast 173748, lung 38938, colorectal 31722, prostate 22848, ovary 16065, liver 9444, pancreas 9158). A total of 2297(0.8%) of patients had incident CVM. Lung(10-year cumulative CVM 2.4%) and liver(1.73%) cancers had the highest incidence of CVM, while breast(0.6%) and prostate(1.2%) had the lowest CVM mortality, even after multiple adjustments(P < 0.001). Overall, there was a significant improvement in CVM since 1990 [2005-2012 vs 1990-1994, adjusted HR 0.63(0.54-0.72), P < 0.001]. This was driven by improvements in CVM in lung cancers(P = 0.02), breast(P < 0.001), and a trend in ovarian cancer(P = 0.097).There was no statistically significant improvement in CVM among survivors of colorectal, pancreatic, liver, or prostate cancers.CONCLUSION: The risk of CVM differs among different cancers, and is highest among survivors of lung and liver cancers. The incidence of CVM has decreased over the past 2 decades mainly among survivors of lung and breast cancers.

  4. Low implementation of Xpert MTB/RIF among HIV/TB co-infected adults in the International epidemiologic Databases to Evaluate AIDS (IeDEA) program (United States)

    Blevins, Meridith; Lindegren, Mary Lou; Yotebieng, Marcel; Nguyen, Dung Thi; Omondi, Alfred; Michael, Denna; Zannou, Djimon Marcel; Carriquiry, Gabriela; Pettit, April


    Objective Xpert MTB/RIF is recommended by the World Health Organization (WHO) as the initial tuberculosis (TB) diagnostic test in individuals suspected of HIV-associated TB. We sought to evaluate field implementation of Xpert among a cohort of HIV/TB co-infected individuals, including availability, utilization and outcomes. Design Observational cohort study (patient-level data) and cross-sectional study (site-level Xpert availability data). Methods Data were collected at 30 participating International epidemiologic Databases to Evaluate AIDS (IeDEA) sites in 18 countries from January 2012-January 2016. All patients were HIV-infected and diagnosed with TB, either bacteriologically or clinically, and followed until a determination of TB treatment outcome. We used multivariable modified Poisson regression to estimate adjusted relative risk (RR) and 95% confidence intervals for unfavorable TB treatment outcomes. Results Most sites (63%) had access to Xpert, either in the clinic (13%), in the same facility (20%) or offsite (30%). Among 2722 HIV/TB patients included, median age was 35.4 years and 41% were female; BMI and CD4 count were low. Overall, most patients (76%) received at least one TB test; 45% were positive. Only 4% of all patients were tested using Xpert: 64% were Xpert-positive, 13% showed rifampicin (RIF) resistance and 30% were extrapulmonary (EPTB) or both pulmonary-EPTB. Treatment outcomes were mostly favorable (77%) and we found little association between Xpert use and an unfavorable TB treatment outcome (RR 1.25, 95%CI: 0.83, 1.90). Conclusions In this cohort, Xpert utilization was low even though the majority of sites had access to the test. Our findings show the need for expanded implementation and further research exploring barriers to use in low-resource settings. PMID:28182705

  5. Conditional Survival in Pediatric Malignancies: Analysis of data from the Childhood Cancer Survivor Study and the Surveillance, Epidemiology and End Results Program (United States)

    Mertens, Ann C; Yong, Jian; Dietz, Andrew; Kreiter, Erin; Yasui, Yutaka; Bleyer, Archie; Armstrong, Gregory T; Robison, Leslie L; Wasilewski-Masker, Karen


    Background Long-term survivors of pediatric cancer are at risk for life-threatening late effects of their cancer. Previous studies have shown excesses in long-term mortality within high-risk groups defined by demographic and treatment characteristics. Methods To investigate conditional survival in a pediatric cancer population, we performed an analysis of conditional survival in the original Childhood Cancer Survivor Study (CCSS) cohort and the Surveillance, Epidemiology and End Results (SEER) database registry. The overall probability of death for patients in 5 years and 10 years after they survived 5, 10, 15, and 20 years since cancer diagnosis, and cause-specific death in 10 years for 5-year survivors were estimated using the cumulative incidence method. Results Among CCSS and SEER patients who were alive 5 years post cancer diagnosis, within each diagnosis group at least 92% are alive in the subsequent 5 years, except leukemia patients of whom only 88% of 5-year survivors remain alive in the subsequent 5 years. The probability of all-cause mortality in the next 10 years on patients who survived at least 5 years after diagnosis, was 8.8% in CCSS and 10.6% in SEER, approximately three quarter of which were due to neoplasms as causes of death. Conclusion The risk of death of pediatric cancer survivors in 10 years can vary between diagnosis groups by at most 12% even up to 20 years post diagnosis. This information is clinically important in counseling patients on their conditional survival, particularly when survivors are seen in long-term follow-up. PMID:25557134

  6. Epidemiology: Then and Now. (United States)

    Kuller, Lewis H


    Twenty-five years ago, on the 75th anniversary of the Johns Hopkins Bloomberg School of Public Health, I noted that epidemiologic research was moving away from the traditional approaches used to investigate "epidemics" and their close relationship with preventive medicine. Twenty-five years later, the role of epidemiology as an important contribution to human population research, preventive medicine, and public health is under substantial pressure because of the emphasis on "big data," phenomenology, and personalized medical therapies. Epidemiology is the study of epidemics. The primary role of epidemiology is to identify the epidemics and parameters of interest of host, agent, and environment and to generate and test hypotheses in search of causal pathways. Almost all diseases have a specific distribution in relation to time, place, and person and specific "causes" with high effect sizes. Epidemiology then uses such information to develop interventions and test (through clinical trials and natural experiments) their efficacy and effectiveness. Epidemiology is dependent on new technologies to evaluate improved measurements of host (genomics), epigenetics, identification of agents (metabolomics, proteomics), new technology to evaluate both physical and social environment, and modern methods of data collection. Epidemiology does poorly in studying anything other than epidemics and collections of numerators and denominators without specific hypotheses even with improved statistical methodologies.

  7. Curriculum design of emergency medical services program at the College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences

    Directory of Open Access Journals (Sweden)

    Alanazi AF


    Full Text Available Abdullah Foraih AlanaziCollege of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi ArabiaBackground: The emergency medical services program at the College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia, was adapted from the integrated problem-based learning curriculum of Flinders University, Adelaide, South Australia.Purpose: The purpose of this article is to discuss the major adaptations required for adoption of the full-fledged PBL curriculum, use of sequential blocks, and multilayer alignment of the curriculum.Methods: A logical model and step-by-step approach were used to design the curriculum. Several studies using Delphi methods, focus group interviews, and expert opinions were performed to identify the priority health problems; related competencies, learning objectives, and learning strategies; the web-based curriculum for delivery; student assessment; and program evaluation.Results: Sixty priority health problems were identified for inclusion in different blocks of the curriculum. Identified competencies matched the satisfaction of different stakeholders, and ascertained learning objectives and strategies were aligned with the competencies. A full-fledged web-based curriculum was designed and an assessment was created that aligned with a blueprint of the objectives and the mode of delivery.Conclusion: Step-by-step design ensures the multilayer alignment of the curriculum, including priority health problems, competencies, objectives, student assessment, and program evaluation.Keywords: emergency medical services, problem-based learning, logical model, step-by-step approach, multilayer alignment

  8. Evolution and social epidemiology. (United States)

    Nishi, Akihiro


    Evolutionary biology, which aims to explain the dynamic process of shaping the diversity of life, has not yet significantly affected thinking in social epidemiology. Current challenges in social epidemiology include understanding how social exposures can affect our biology, explaining the dynamics of society and health, and designing better interventions that are mindful of the impact of exposures during critical periods. I review how evolutionary concepts and tools, such as fitness gradient in cultural evolution, evolutionary game theory, and contemporary evolution in cancer, can provide helpful insights regarding social epidemiology.

  9. The Integrated Clinical Anatomy Program at Alfaisal University: an innovative model of teaching clinically applied functional anatomy in a hybrid curriculum. (United States)

    Yaqinuddin, Ahmed; Ikram, Muhammad Faisal; Zafar, Muhammad; Eldin, Nivin Sharaf; Mazhar, Muhammad Atif; Qazi, Sadia; Shaikh, Aftab Ahmed; Obeidat, Akef; Al-Kattan, Khaled; Ganguly, Paul


    Anatomy has historically been a cornerstone in medical education regardless of specialty. It is essential for physicians to be able to perform a variety of tasks, including performing invasive procedures, examining radiological images, performing a physical examination of a patient, etc. Medical students have to be prepared for such tasks, and we can assist this by changing the way that we educate students in medical schools. Thus, newer medical curricula need to be designed according to needs of future physicians. In this report, we describe a unique program called the Integrated Clinical Anatomy Program (ICAP). The ICAP was developed at the College of Medicine of Alfaisal University in the Kingdom of Saudi Arabia. Here, we describe the unique features of this program, including the structure and facilities of the Anatomy Resource Center. The Anatomy Resource Center plays a pivotal role in engaging the students for faculty-directed structured laboratory sessions as well as peer-assisted uniform student-centered learning. The ICAP has shown great promise, as reflected by early results from a nationwide progress test. Students from all years of the Alfaisal University medical school scored significantly higher than the national average on the anatomy and physiology component of the nationwide progress test examination, with P values of 0.0179 and 0.0015, respectively. We believe that the ICAP can be used as a model for teaching clinically applied functional anatomy to medical students in a hybrid curriculum around the world.

  10. The application of epidemiology in national veterinary services: Challenges and threats in Brazil. (United States)

    Gonçalves, Vitor Salvador Picão; de Moraes, Geraldo Marcos


    The application of epidemiology in national veterinary services must take place at the interface between science and politics. Animal health policy development and implementation require attention to macro-epidemiology, the study of economic, social and policy inputs that affect the distribution and impact of animal or human disease at the national level. The world has changed fast over the last three decades including the delivery of veterinary services, their remit and the challenges addressed by public and animal health policies. Rethinking the role of public services and how to make public programs more efficient has been at the heart of the political discussion. The WTO through its SPS Agreement has changed the way in which national veterinary services operate and how trade decisions are made. Most low and middle income countries are still struggling to keep up with the new international scene. Some of these countries, such as Brazil, have very important livestock industries and are key to the global food systems. Over the last two decades, Brazil became a leading player in exports of livestock products, including poultry, and this created a strong pressure on the national veterinary services to respond to trade demands, leading to focus animal health policies on the export-driven sector. During the same period, Brazil has gone a long way in the direction of integrating epidemiology with veterinary services. Epidemiology groups grew at main universities and have been working with government to provide support to animal health policy. The scope and quality of the applied epidemiological work improved and focused on complex data analysis and development of technologies and tools to solve specific disease problems. Many public veterinary officers were trained in modern epidemiological methods. However, there are important institutional bottlenecks that limit the impact of epidemiology in evidence-based decision making. More complex challenges require high levels

  11. Cancer Epidemiology Cohorts (United States)

    Cohort studies are fundamental for epidemiological research by helping researchers better understand the etiology of cancer and provide insights into the key determinants of this disease and its outcomes.

  12. Advances in spatial epidemiology and geographic information systems. (United States)

    Kirby, Russell S; Delmelle, Eric; Eberth, Jan M


    The field of spatial epidemiology has evolved rapidly in the past 2 decades. This study serves as a brief introduction to spatial epidemiology and the use of geographic information systems in applied research in epidemiology. We highlight technical developments and highlight opportunities to apply spatial analytic methods in epidemiologic research, focusing on methodologies involving geocoding, distance estimation, residential mobility, record linkage and data integration, spatial and spatio-temporal clustering, small area estimation, and Bayesian applications to disease mapping. The articles included in this issue incorporate many of these methods into their study designs and analytical frameworks. It is our hope that these studies will spur further development and utilization of spatial analysis and geographic information systems in epidemiologic research.

  13. Web tools for molecular epidemiology of tuberculosis. (United States)

    Shabbeer, Amina; Ozcaglar, Cagri; Yener, Bülent; Bennett, Kristin P


    In this study we explore publicly available web tools designed to use molecular epidemiological data to extract information that can be employed for the effective tracking and control of tuberculosis (TB). The application of molecular methods for the epidemiology of TB complement traditional approaches used in public health. DNA fingerprinting methods are now routinely employed in TB surveillance programs and are primarily used to detect recent transmissions and in outbreak investigations. Here we present web tools that facilitate systematic analysis of Mycobacterium tuberculosis complex (MTBC) genotype information and provide a view of the genetic diversity in the MTBC population. These tools help answer questions about the characteristics of MTBC strains, such as their pathogenicity, virulence, immunogenicity, transmissibility, drug-resistance profiles and host-pathogen associativity. They provide an integrated platform for researchers to use molecular epidemiological data to address current challenges in the understanding of TB dynamics and the characteristics of MTBC.

  14. A Hybrid Approach Using an Artificial Bee Algorithm with Mixed Integer Programming Applied to a Large-Scale Capacitated Facility Location Problem

    Directory of Open Access Journals (Sweden)

    Guillermo Cabrera G.


    Full Text Available We present a hybridization of two different approaches applied to the well-known Capacitated Facility Location Problem (CFLP. The Artificial Bee algorithm (BA is used to select a promising subset of locations (warehouses which are solely included in the Mixed Integer Programming (MIP model. Next, the algorithm solves the subproblem by considering the entire set of customers. The hybrid implementation allows us to bypass certain inherited weaknesses of each algorithm, which means that we are able to find an optimal solution in an acceptable computational time. In this paper we demonstrate that BA can be significantly improved by use of the MIP algorithm. At the same time, our hybrid implementation allows the MIP algorithm to reach the optimal solution in a considerably shorter time than is needed to solve the model using the entire dataset directly within the model. Our hybrid approach outperforms the results obtained by each technique separately. It is able to find the optimal solution in a shorter time than each technique on its own, and the results are highly competitive with the state-of-the-art in large-scale optimization. Furthermore, according to our results, combining the BA with a mathematical programming approach appears to be an interesting research area in combinatorial optimization.

  15. Effect of Educational Program to Encourage Safe Sexual Behaviors Among Addicted Men Refered to Substance Abuse Treatment Centers in Hamadan, Western Iran: Applying the Theory of Planned Behavior

    Directory of Open Access Journals (Sweden)

    Babak Moeini


    Full Text Available Introduction: Unsafe sexual behaviors as important risky behaviors can expose individuals and society to dangerous infectious disease such as AIDS and viral hepatitis. Considering the high prevalence of unsafe sexual behaviors, this study aimed to determine the effect of educational programs to encourage safe sexual behaviors among substance abusers referred to substance abuse treatment centers in Hamadan, Western Iran by applying the theory of planned behavior. Materials & Methods: This quasi-experimental study was performed on 104 men substance abusers (52 participants in each of the control and intervention groups referred to substance abuse treatment centers in Hamadan. Data collection tool was a questionnaire containing demographic information and the theory of planned behavior constructs. Before the educational program, questionnaires were completed by both groups. After the pretest in both groups, participants in the intervention group participated in four educational sessions designed based on the theory of planned behavior. Two months after the end of program, posttest was performed. Data was analyzed using independent T-test, chi-square, fisher exact test, McNemar’s test and multiple linear regressions using SPSS-16. Results: After educational intervention, the mean scores of the theory constructs (attitude toward behavior, subjective norms, behavioral control, behavioral intention and behaviors, in the intervention group increased significantly (P<0.05, despite the fact, changes were not significant in the control group. Conclusion: Implementation of educational courses to encourage safe sexual behaviors based on the theory of planned behavior can be beneficial for substance abusers referred to substance abuse treatment centers.

  16. The Investigations for Developing Applied Programs Using Wavelet Software WAVELAB%利用WAVELAB开发小波应用程序的研究

    Institute of Scientific and Technical Information of China (English)

    樊启斌; 李虹; 张根寿


     This paper analyzes the system structure and developing environment on wavelet analysissoftware WAVELAB,and investigates the problem of developing applied wavelet software basedon WAVELAB. An example compressing Lena image by wavelet methods is given, which includesa simple MATLAB program with several results from running the program. The experimentshows that developing applied prograrns with wavelet software WAVELAB is feasible, gettingtwice the result with half the effort, and of important significance.

  17. Proceedings of the third international molecular pathological epidemiology (MPE) meeting. (United States)

    Campbell, Peter T; Rebbeck, Timothy R; Nishihara, Reiko; Beck, Andrew H; Begg, Colin B; Bogdanov, Alexei A; Cao, Yin; Coleman, Helen G; Freeman, Gordon J; Heng, Yujing J; Huttenhower, Curtis; Irizarry, Rafael A; Kip, N Sertac; Michor, Franziska; Nevo, Daniel; Peters, Ulrike; Phipps, Amanda I; Poole, Elizabeth M; Qian, Zhi Rong; Quackenbush, John; Robins, Harlan; Rogan, Peter K; Slattery, Martha L; Smith-Warner, Stephanie A; Song, Mingyang; VanderWeele, Tyler J; Xia, Daniel; Zabor, Emily C; Zhang, Xuehong; Wang, Molin; Ogino, Shuji


    Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformatics, and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatment efforts in population health and clinical medicine. Although MPE research has been commonly applied to investigating breast, lung, and colorectal cancers, its methodology can be used to study most diseases. Recent successes in MPE studies include: (1) the development of new statistical methods to address etiologic heterogeneity; (2) the enhancement of causal inference; (3) the identification of previously unknown exposure-subtype disease associations; and (4) better understanding of the role of lifestyle/behavioral factors on modifying prognosis according to disease subtype. Central challenges to MPE include the relative lack of transdisciplinary experts, educational programs, and forums to discuss issues related to the advancement of the field. To address these challenges, highlight recent successes in the field, and identify new opportunities, a series of MPE meetings have been held at the Dana-Farber Cancer Institute in Boston, MA. Herein, we share the proceedings of the Third International MPE Meeting, held in May 2016 and attended by 150 scientists from 17 countries. Special topics included integration of MPE with immunology and health disparity research. This meeting series will continue to provide an impetus to foster further transdisciplinary integration of divergent scientific fields.

  18. Real-time molecular epidemiology of tuberculosis by direct genotyping of smear-positive clinical specimens. (United States)

    Alonso, María; Herranz, Marta; Martínez Lirola, Miguel; González-Rivera, Milagros; Bouza, Emilio; García de Viedma, Darío


    We applied MIRU-VNTR (mycobacterial interspersed repetitive-unit-variable-number tandem-repeat typing) to directly analyze the bacilli present in 61 stain-positive specimens from tuberculosis patients. A complete MIRU type (24 loci) was obtained for all but one (no amplification in one locus) of the specimens (98.4%), and the allelic values fully correlated with those obtained from the corresponding cultures. Our study is the first to demonstrate that real-time genotyping of Mycobacterium tuberculosis can be achieved, fully transforming the way in which molecular epidemiology techniques can be integrated into control programs.

  19. Epidemiology of childhood food allergy. (United States)

    Dyer, Ashley A; Gupta, Ruchi


    Food allergy is a public health problem that affects nearly 6 million children in the United States. The extent to which children, families, and communities live with food allergies varies as much as the range of clinical symptoms associated with the disease itself. Food allergy is defined as the reproducible adverse event that elicits a pathologic immunoglobulin E (IgE)-mediated or non-IgE-mediated reaction. Once an allergic child ingests a specific food allergen, the reaction can result in clinical symptoms ranging from mild hives to life-threatening anaphylaxis.Not surprisingly, food allergies have been shown to limit social interactions and impair children's quality of life due to the ubiquity of food where children live, learn, and play. To ensure the safety of our children, the development of sound policy, clinical practice, and health programs must be informed by current research characterizing childhood food allergy at the population level. To set the stage for understanding the current evidence base, this article reviews: 1) epidemiology of childhood food allergy; 2) severity of symptoms; 3) geographic distribution of childhood food allergy; 4) tolerance; 5) economic impact of childhood food allergy; and 6) future directions in childhood food allergy epidemiological research.

  20. Current practice of epidemiology in Africa: highlights of the 3rd conference of the African epidemiological association and 1st conference of the Cameroon society of epidemiology, Yaoundé, Cameroon, 2014. (United States)

    Nkwescheu, Armand Seraphin; Fokam, Joseph; Tchendjou, Patrice; Nji, Akindeh; Ngouakam, Hermann; Andre, Bita Fouda; Joelle, Sobngwi; Uzochukwu, Benjamin; Akinroye, Kingsley; Mbacham, Wilfred; Colizzi, Vittorio; Leke, Rose; Victora, Cesar


    As the study of disease occurrence and health indicators in human populations, Epidemiology is a dynamic field that evolves with time and geographical context. In order to update African health workers on current epidemiological practices and to draw awareness of early career epidemiologists on concepts and opportunities in the field, the 3(rd) African Epidemiology Association and the 1st Cameroon Society of Epidemiology Conference was organized in June 2-6, 2014 at the Yaoundé Mont Febe Hotel, in Cameroon. Under the theme«Practice of Epidemiology in Africa: Stakes, Challenges and Perspectives», the conference attracted close to five hundred guest and participants from all continents. The two main programs were the pre-conference course for capacity building of African Early Career epidemiologists, and the conference itself, providing a forum for scientific exchanges on recent epidemiological concepts, encouraging the use of epidemiological methods in studying large disease burden and neglected tropical diseases; and highlighting existing opportunities.

  1. Recognizing Excellence in Maternal and Child Health (MCH) Epidemiology: The 2014 National MCH Epidemiology Awards (United States)

    Vladutiu, Catherine J.; Jones, Jessica R.


    Purpose The impact of programs, policies, and practices developed by professionals in the field of maternal and child health (MCH) epidemiology is highlighted biennially by 16 national MCH agencies and organizations, or the Coalition for Excellence in MCH Epidemiology. Description In September 2014, multiple leading agencies in the field of MCH partnered to host the national CityMatCH Leadership and MCH Epidemiology Conference in Phoenix, Arizona. The conference offered opportunities for peer exchange; presentation of new scientific methodologies, programs, and policies; dialogue on changes in the MCH field; and discussion of emerging MCH issues relevant to the work of local, state, and national MCH professionals. During the conference, the National MCH Epidemiology Awards were presented to individuals, teams, institutions, and leaders for significantly contributing to the improved health of women, children, and families. Assessment During the conference, the Coalition presented seven deserving health researchers and research groups with national awards in the areas of advancing knowledge, effective practice, outstanding leadership, young professional achievement, and lifetime achievement. The article highlights the accomplishments of these national-level awardees. Conclusion Recognition of deserving professionals strengthens the field of MCH epidemiology, and sets the standard for exceptional research, mentoring, and practice. PMID:26723200

  2. The dynamics of tuberculosis epidemiology. (United States)

    Rieder, Hans L


    A conceptual framework to study the epidemiologic basis of tuberculosis control is provided. The basic model to discuss the epidemiology of tuberculosis is based on a classification of tuberculosis based on its pathogenesis with exposure, latent infection, tuberculosis, and death from tuberculosis, showing the conditional probabilities leading from one to the next step in the chain of events. Historical data are utilized to demonstrate how the dynamics of tuberculosis over multiple decades have contributed to shape the present. It is shown that the key concept to understand the dynamics is related to current and past incidence and prevalence of latent infection with M. tuberculosis. The dynamics of the epidemic are shaped both by the behaviour of the causative organism of tuberculosis as well as the population structure and changes that take place in parallel in which M. tuberculosis thrives. Both the present and the future shape of the epidemic, as well as the principles applied to its control lie very much in the past of a society. While new risk factors such as HIV or diabetes have been or are emerging more strongly, it is noted that the majority of all new cases emerging cannot be pinned to one or the other such factor. It is the historical experience of a population that offers the most valuable key to understanding the present and the future.

  3. Effects of Reducing Antimicrobial Use and Applying a Cleaning and Disinfection Program in Veal Calf Farming: Experiences from an Intervention Study to Control Livestock-Associated MRSA.

    Directory of Open Access Journals (Sweden)

    Alejandro Dorado-García

    Full Text Available With the ultimate aim of containing the emergence of resistant bacteria, a Dutch policy was set in place in 2010 promoting a reduction of antimicrobial use (AMU in food-producing animals. In this context, a study evaluated strategies to curb livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA. Fifty-one veal calf farms were assigned to one of 3 study arms: RAB farms reducing antimicrobials by protocol; RAB-CD farms reducing antimicrobials by protocol and applying a cleaning and disinfection program; and Control farms without interventions. MRSA carriage was tested in week 0 and week 12 of 2 consecutive production cycles in farmers, family members and veal calves. Interventions were validated and a cyclic rise in MRSA-prevalence in animals was shown with a more moderate increase in RAB farms. Prevalence in humans declined parallel over time in the study arms but RAB farms were at the lowest MRSA levels from the beginning of the study. In RAB-CD farms, human and animal prevalence did not differ from Control farms and MRSA air loads were significantly higher than in the other study arms. Mimicking the national trend, an overall AMU decrease (daily dosages per animal per cycle (DDDA/C was observed over 4 pre-study and the 2 study cycles; this trend did not have a significant effect on a set of evaluated farm technical parameters. AMU was positively associated with MRSA across study arms (ORs per 10 DDDA/C increase = 1.26 for both humans (p = 0.07 and animals (p = 0.12 in first cycle. These results suggest that AMU reduction might be a good strategy for curbing MRSA in veal calf farming, however the specific cleaning and disinfecting program in RAB-CD farms was not effective. The drop in MRSA prevalence in people during the study could be attributed to the observed long-term AMU decreasing trend.


    Directory of Open Access Journals (Sweden)

    Viorica Lefter


    Full Text Available Objectives. The objective of the present study is to relieve the necessity and the efficiency of the kinetic recovery of theoperated hip, and to increase the orthopedist’s trust in the kinetic act as a medical act executed in a responsible and understanding fashion by the qualified staff. Arthroplasty refers to the replacement of a joint deteriorated by a certain pathological process (degenerative arthritis, infection, or tumor with an artificial one, named endoprosthesis, a joint which must remain perfectly functional. The material and the method. The participants were 76 (63% mail patients and 45 (37% female patients, 44 (37% of which with ages between 40 and 60 years, 54 (45% between 60 and 70, and 21 (18% exceeded 70 years of ageInclusion criteria for the study werethe display of the following symptoms: chronic pain, acute pain andmobility reduction. Thus, 52 (42% patients featured acute pain, 42 (33% chronic pain and 35 (27% mobility disorders accompanied by walk disorders, that is, tilting pelvis 67 (55% and limping 54 (45% (Fig. 3, (Fig. 4 with hip prostheses of different types and at various intervals from the intervention. Subjects were clinically, functionally, radiologically and MRI investigated, preoperatively, postoperatively, after 3 months and after 1 year. A recovery program featuring educational, hygienic, diet, medication and physical-kinetic aspects was applied daily for a 14 to 15-day period, followed by kinesiotherapy and massage 2 to 3 times a week, by reevaluation and by a complete treatment at 3 months and at 1 year, respectively. Monitoring was made by the VAS scale for pain, Womac Lequesne for the functional status and Tinetii for the walk. Results. All patients have been evaluated initially, after 10 days and at the completion of the treatment, after 3 months and after 1 year. The recovery of hip arthroplasty must be carried out in time and maintained for the entire life.Conclusions.. Hips with applied endo

  5. Collaborative Approaches to Increase the Utility of Spatial Data for the Wildfire Management Community Through NASA's Applied Remote Sensing Training Program (United States)

    McCullum, A. J. K.; Schmidt, C.; Blevins, B.; Weber, K.; Schnase, J. L.; Carroll, M.; Prados, A. I.


    The utility of spatial data products and tools to assess risk and effectively manage wildfires has increased, highlighting the need for communicating information about these new capabilities to decision makers, resource managers, and community leaders. NASA's Applied Remote Sensing Training (ARSET) program works directly with agencies and policy makers to develop in-person and online training courses that teach end users how to access, visualize, and apply NASA Earth Science data in their profession. The expansion of ARSET into wildfire applications began in 2015 with a webinar and subsequent in-person training hosted in collaboration with Idaho State University's (ISU) GIS Training and Research Center (TReC). These trainings featured presentations from the USDA Forest Service's Remote Sensing Training and Applications Center, the Land Processes DAAC, Northwest Nazarene University, NASA Goddard Space Flight Center, and ISU's GIS TReC. The webinar focused on providing land managers, non-governmental organizations, and international management agencies with an overview of 1) remote sensing platforms for wildfire applications, 2) products for pre- and post-fire planning and assessment, 3) the use of terrain data, 4) new techniques and technologies such as Unmanned Aircraft Systems and the Soil Moisture Active Passive Mission (SMAP), and 5) the RECOVER Decision Support System. This training highlighted online tools that engage the wildfire community through collaborative monitoring and assessment efforts. Webinar attendance included 278 participants from 178 organizations in 42 countries and 33 US states. The majority of respondents (93%) from a post-webinar survey indicated they displayed improvement in their understanding of specific remote-sensing data products appropriate for their work needs. With collaborative efforts between federal, state, and local agencies and academic institutions, increased use of NASA Earth Observations may lead to improved near real

  6. Epidemiology of Down Syndrome (United States)

    Sherman, Stephanie L.; Allen, Emily G.; Bean, Lora H.; Freeman, Sallie B.


    Down syndrome (DS) is the most commonly identified genetic form of mental retardation and the leading cause of specific birth defects and medical conditions. Traditional epidemiological studies to determine the prevalence, cause, and clinical significance of the syndrome have been conducted over the last 100 years. DS has been estimated to occur…

  7. Molecular epidemiology of ascariasis

    DEFF Research Database (Denmark)

    Betson, Martha; Halstead, Fennella; Nejsum, Peter;

      We are using molecular epidemiology techniques to study the population structure of Ascaris obtained from humans and pigs. Worms were obtained from human hosts on Zanzibar and in Uganda, Bangladesh, Guatemala and Nepal and Ascaris from pigs were collected from in Uganda, Tanzania, Denmark...

  8. Inflammatory bowel disease epidemiology

    DEFF Research Database (Denmark)

    Burisch, Johan; Munkholm, Pia


    The occurrence of inflammatory bowel disease (IBD) is increasing worldwide, yet the reasons remain unknown. New therapeutic approaches have been introduced in medical IBD therapy, but their impact on the natural history of IBD remains uncertain. This review will summarize the recent findings in t...... in the epidemiology of IBD....

  9. [Toxoplasmosis: Epidemiology, Diagnosis, Treatment]. (United States)

    Khryanin, A A; Reshetnikov, O V; Kuvshinova, I N


    The up-to-date literature and original data on the epidemiology, diagnosis and treatment of toxoplasmosis are presented. Particular attention is paid to the parasite infection during pregnancy. Spiramycin is the drug of choice for acute toxoplasmosis in pregnant women.

  10. Ophthalmic epidemiology in Europe

    DEFF Research Database (Denmark)

    Delcourt, Cécile; Korobelnik, Jean-François; Buitendijk, Gabriëlle H S


    The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 Euro...

  11. Epidemiology of burns

    NARCIS (Netherlands)

    Dokter, Jan


    The aim of this thesis is to understand the epidemiology, treatment and outcomes of specialized burn care in The Netherlands. This thesis is mainly based on historical data of the burn centre in Rotterdam from 1986, combined with historical data from the burn centres in Groningen and Beverwijk from

  12. Epidemiology of acute wrist trauma

    DEFF Research Database (Denmark)

    Larsen, C F; Lauritsen, Jens


    Epidemiological data on wrist injuries in a population can be used for planning by applying them to criteria for care and thus deriving estimates of provisions for care according to currently desirable standards. In a 1-year study all patients > or = 15 years with acute wrist trauma and treated...... in the emergency room were examined according to an algorithm until a diagnosis was established. The overall incidence of wrist trauma was 69 per 10,000 inhabitants per year. Incidence of wrist trauma requiring x-ray examination was 58 per 10,000 per year. The incidence of distal radius fractures was 27 per 10...... using data from a population-based study. A completeness rate of 0.56 (95% confidence interval: 0.31-0.78) was found. An x-ray had been taken for all patients reporting a fracture thus justifying the use of fractures as an incidence measure when comparing groups of patients with wrist trauma....

  13. 1995 annual epidemiologic surveillance report for Fernald Environmental Management Project

    Energy Technology Data Exchange (ETDEWEB)



    The US Department of Energy's (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. During the past several years, a number of DOE sites have participated in the Epidemiologic Surveillance Program. This program monitors illnesses and health conditions that result in an absence of five or more consecutive workdays, occupational injuries and illnesses, and disabilities and deaths among current workers. This report provides a summary of epidemiologic surveillance data collected from the Fernald Environmental Management Project (FEMP) from January 1, 1995 through December 31, 1995. The data were collected by a coordinator at FEMP and submitted to the Epidemiologic Surveillance Data Center, located at Oak Ridge Institute for Science and Education, where quality control procedures and data analyses were carried out.

  14. 1995 Annual epidemiologic surveillance report for Brookhaven National Laboratory

    Energy Technology Data Exchange (ETDEWEB)



    The US Department of Energy`s (DOE) conduct of epidemiologic surveillance provides an early warning system for health problems among workers. This program monitors illnesses and health conditions that result in an absence of five or more consecutive workdays, occupational injuries and illnesses, and disabilities and deaths among current workers. This report summarizes epidemiologic surveillance data collected from Brookhaven National Laboratory (BNL) from January 1, 1995 through December 31, 1995. The data were collected by a coordinator at BNL and submitted to the Epidemiologic Surveillance Data Center, located at Oak Ridge Institute for Science and Education, where quality control procedures and data analyses were carried out.

  15. Indicadores epidemiológicos aplicáveis a estudos sobre a associação entre saneamento e saúde de base municipal Epidemiological indicators applied to studies about association between water supply and sanitation and health based on data at municipal level

    Directory of Open Access Journals (Sweden)

    Silvano Silvério da Costa


    programs, as well as for identification of priorities, rational planning and funding of water supply and sanitation projects. The present paper is part of a broader study on the selection of sanitary indicators to be used as "sentinel indicators" for prevention and control of diseases associated to water and sanitation. In this context, this paper presents a brief literature review, descriptive statistics of some epidemiological indicators collected from municipalities of 4 Brazilian States, as well as a discussion on the applicability of these indicators in studies of this nature. Among the epidemiological indicators evaluated, infant mortality, diarrhoea mortality in children under 5 years old and the diarrhoea morbidity in children under 5 years old based on data from the Brazilian Monitoring of Acute Diarrhoeal Disease program seem to be the more adequate.

  16. Molecular Epidemiology of Foodborne Pathogens (United States)

    Chen, Yi; Brown, Eric; Knabel, Stephen J.

    The purpose of this chapter is to describe the basic principles and advancements in the molecular epidemiology of foodborne pathogens. Epidemiology is the study of the distribution and determinants of infectious diseases and/or the dynamics of disease transmission. The goals of epidemiology include the identification of physical sources, routes of transmission of infectious agents, and distribution and relationships of different subgroups. Molecular epidemiology is the study of epidemiology at the molecular level. It has been defined as "a science that focuses on the contribution of potential genetic and environmental risk factors, identified at the molecular level, to the etiology, distribution and prevention of diseases within families and across populations".

  17. 中国2005-2008年肾综合征出血热监测及疫情分析%Epidemiology and surveillance programs on hemorrhagic fever with renal syndrome in Mainland China, 2005-2008

    Institute of Scientific and Technical Information of China (English)

    王芹; 周航; 韩仰欢; 王晓芳; 王世文; 殷文武; 李群; 许真


    Objective To analyze the epidemiologic and surveillance data of hemorrhagic fever with renal syndrome (HERS) in China, from 2005 to 2008, to describe the epidemiology and trend of HERS. Methods Descriptive epidemiology were studied to analyze the surveillance data from 2005 to 2008, collected from both the internet-based national notifiable disease reporting system and 40 HFRS sentinel sites developed since 2005 in 40 counties around China. Results A total of 56 077 HERS cases and 692 deaths reported in China with case fatality rate as 1.23%. Morbidity and mortality had been annually decreasing since 2004. The top 7 provinces with HFRS cases were Heilongjiang, Lianning, Jilin, Shandong, Shaanxi, Hebei and Zhejiang, which had a total of 44 081 cases reported, accounting for 78.61% of the total number of cases, in the nation. More cases were reported in spring and autumn-winter season, with the peak in November. Cases reported in males were 3.13 times of the females and most cases seen in young and middle-aged farmers. The density and the virus carrying rate of animal hosts and the distribution of dominant species were relatively stable and similar to the previous findings. Apodemus agrarius and Rattus norvegicus were still the most common and predominant animal hosts. No genetic mutation of Hantavirus was detected in the surveillance program. Conclusion The continuous descending trend of the HERS epidemics could be related to the successful strategies on comprehensive prevention and control measures, as controlling the number of rodents and vectors, carrying out HERS vaccination campaign and health education by the local health care takers in the recent years. Implementation of the new national Expanded Program of Immunization on HFRS vaccine in high-risk areas may further reduce the epidemics. However,both the density and the virus carried rate among the host animals remain high in some areas, together with the emergence of new epidemic areas, all call for more

  18. myEpi. Epidemiology of one

    Directory of Open Access Journals (Sweden)

    Georgiy eBobashev


    Full Text Available A new concept of within-individual epidemiology termed myEpi is introduced. It is argued that traditional epidemiological methods, which are usually applied to populations of humans, can be applicable to a single individual and thus used for self-monitoring and forecasting of epidemic outbreaks within an individual. Traditional epidemiology requires that results be generalizable to a predefined population. The key component of myEpi is that a single individual may be viewed as an entire population of events and thus the analysis should be generalizable to this population. Applications of myEpi are aimed for, but not limited to, the analysis of data collected by individuals with the help of wearable sensors and digital diaries. These data can include physiological measures and records of healthy and risky behaviors (e.g., exercise, sleep, smoking, food consumption, alcohol and drug use. Although many examples of within-individual epidemiology exist, there is a pressing need for systematic guidance to the analysis and interpretation of intensive individual-level data. myEpi serves this need by adapting statistical methods (e.g. regressions, hierarchical models, survival analysis, agent-based models to individual-level data.

  19. myEpi. Epidemiology of One. (United States)

    Bobashev, Georgiy


    A new concept of within-individual epidemiology termed "myEpi" is introduced. It is argued that traditional epidemiological methods, which are usually applied to populations of humans, can be applicable to a single individual and thus used for self-monitoring and forecasting of "epidemic" outbreaks within an individual. Traditional epidemiology requires that results be generalizable to a predefined population. The key component of myEpi is that a single individual may be viewed as an entire population of events and thus, the analysis should be generalizable to this population. Applications of myEpi are aimed for, but not limited to, the analysis of data collected by individuals with the help of wearable sensors and digital diaries. These data can include physiological measures and records of healthy and risky behaviors (e.g., exercise, sleep, smoking, food consumption, alcohol, and drug use). Although many examples of within-individual epidemiology exist, there is a pressing need for systematic guidance to the analysis and interpretation of intensive individual-level data. myEpi serves this need by adapting statistical methods (e.g., regressions, hierarchical models, survival analysis, agent-based models) to individual-level data.

  20. Epidemiology of colorectal cancer (United States)

    Marley, Andrew R; Nan, Hongmei


    Colorectal cancer is currently the third deadliest cancer in the United States and will claim an estimated 49,190 U.S. lives in 2016. The purpose of this review is to summarize our current understanding of this disease, based on nationally published statistics and information presented in peer-reviewed journal articles. Specifically, this review will cover the following topics: descriptive epidemiology (including time and disease trends both in the United States and abroad), risk factors (environmental, genetic, and gene-environment interactions), screening, prevention and control, and treatment. Landmark discoveries in colorectal cancer risk factor research will also be presented. Based on the information reviewed for this report, we suggest that future U.S. public health efforts aim to increase colorectal cancer screening among African American communities, and that future worldwide colorectal cancer epidemiology studies should focus on researching nutrient-gene interactions towards the goal of improving personalized treatment and prevention strategies.

  1. Lamont-Doherty's Secondary School Field Research Program: Using Goal-Oriented Applied Research as a Means of Building Comprehensive and Integrated Scientific Understanding (United States)

    Bostick, B. C.; Newton, R.; Vincent, S.; Peteet, D. M.; Sambrotto, R.; Schlosser, P.; Corbett, E.


    Conventional instruction in science often proceeds from the general to the specific and from text to action. Fundamental terminologies, concepts, and ideas that are often abstract are taught first and only after such introductory processes can a student engage in research. Many students struggle to find relevance when presented information without context specific to their own experiences. This challenge is exacerbated for students whose social circles do not include adults who can validate scientific learning from their own experiences. Lamont-Doherty's Secondary School Field Research Program inverts the standard paradigm and places small groups of students in research projects where they begin by performing manageable tasks on complex applied research projects. These tasks are supplemented with informal mentoring and relevant articles (~1 per week). Quantitative metrics suggest the approach is highly successful—most participants report a dramatic increase in their enthusiasm for science, 100% attend college, and approximately 50% declare majors in science or technology. We use one project, the construction of a microbial battery, to illustrate this novel model of science learning and argue that it should be considered a best practice for project-based science education. The goal of this project was to build a rechargeable battery for a mobile phone based on a geochemical cycle, to generate and store electricity. The students, mostly from ethnic groups under-represented in the STEM fields, combined concepts and laboratory methods from biology, chemistry and physics to isolate photosynthetic bacteria from a natural salt marsh, and made an in situ device capable of powering a light bulb. The younger participants had been exposed to neither high school chemistry nor physics at the start of the project, yet they were able to use the project as a platform to deepen their science knowledge and their desire for increased participation in formal science education.

  2. Alberta Stroke Program Early CT Score applied to CT angiography source images is a strong predictor of futile recanalization in acute ischemic stroke

    Energy Technology Data Exchange (ETDEWEB)

    Kawiorski, Michal M.; Alonso de Lecinana, Maria [Hospital Universitario La Paz, IdiPAZ, Universidad Autonoma de Madrid, Madrid (Spain); Hospital Universitario Ramon y Cajal, IRYCIS, Universidad de Alcala de Henares, Madrid (Spain); Martinez-Sanchez, Patricia; Fuentes, Blanca; Sanz-Cuesta, Borja E.; Marin, Begona; Ruiz-Ares, Gerardo; Diez-Tejedor, Exuperio [Hospital Universitario La Paz, IdiPAZ, Universidad Autonoma de Madrid, Madrid (Spain); Garcia-Pastor, Andres; Diaz-Otero, Fernando [Hospital Universitario Gregorio Maranon, IiSGM, Universidad Complutense de Madrid, Madrid (Spain); Calleja, Patricia [Hospital Universitario 12 de Octubre, Universidad Autonoma de Madrid, Madrid (Spain); Lourido, Daniel; Vicente, Agustina; Fandino, Eduardo [Hospital Universitario Ramon y Cajal, IRYCIS, Universidad de Alcala de Henares, Madrid (Spain); Sierra-Hidalgo, Fernando [Hospital Universitario 12 de Octubre, Universidad Autonoma de Madrid, Madrid (Spain); Hospital Universitario Infanta Leonor, Universidad Complutense de Madrid, Madrid (Spain)


    Reliable predictors of poor clinical outcome despite successful revascularization might help select patients with acute ischemic stroke for thrombectomy. We sought to determine whether baseline Alberta Stroke Program Early CT Score (ASPECTS) applied to CT angiography source images (CTA-SI) is useful in predicting futile recanalization. Data are from the FUN-TPA study registry (; NCT02164357) including patients with acute ischemic stroke due to proximal arterial occlusion in anterior circulation, undergoing reperfusion therapies. Baseline non-contrast CT and CTA-SI-ASPECTS, time-lapse to image acquisition, occurrence, and timing of recanalization were recorded. Outcome measures were NIHSS at 24 h, symptomatic intracranial hemorrhage, modified Rankin scale score, and mortality at 90 days. Futile recanalization was defined when successful recanalization was associated with poor functional outcome (death or disability). Included were 110 patients, baseline NIHSS 17 (IQR 12; 20), treated with intravenous thrombolysis (IVT; 45 %), primary mechanical thrombectomy (MT; 16 %), or combined IVT + MT (39 %). Recanalization rate was 71 %, median delay of 287 min (225; 357). Recanalization was futile in 28 % of cases. In an adjusted model, baseline CTA-SI-ASPECTS was inversely related to the odds of futile recanalization (OR 0.5; 95 % CI 0.3-0.7), whereas NCCT-ASPECTS was not (OR 0.8; 95 % CI 0.5-1.2). A score ≤5 in CTA-SI-ASPECTS was the best cut-off to predict futile recanalization (sensitivity 35 %; specificity 97 %; positive predictive value 86 %; negative predictive value 77 %). CTA-SI-ASPECTS strongly predicts futile recanalization and could be a valuable tool for treatment decisions regarding the indication of revascularization therapies. (orig.)

  3. Epidemiology of yaws: an update

    Directory of Open Access Journals (Sweden)

    Kazadi WM


    Full Text Available Walter M Kazadi,1 Kingsley B Asiedu,2 Nsiire Agana,3 Oriol Mitjà4,51Office of the WHO Representative for Papua New Guinea, World Health Organization, Port Moresby, Papua New Guinea; 2Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland; 3Public Health Division, Ghana Health Service, Accra, Ghana; 4Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain; 5Lihir Medical Centre-International SOS, Newcrest Mining, Lihir Island, Papua New GuineaAbstract: Yaws, a neglected tropical disease, is targeted for eradication by 2020 through large-scale mass-treatment programs of endemic communities. A key determinant for the success of the eradication campaign is good understanding of the disease epidemiology. We did a review of historical trends and new information from endemic countries, with the aim of assessing the state of knowledge on yaws disease burden. Transmission of yaws is now present in Africa, Asia, and the South Pacific. At least 12 countries are known to harbor yaws cases and 21 to 42 million people live in endemic areas. Between 2008 and 2012 more than 300,000 new cases were reported to the World Health Organization. Yaws presented high geographical variation within a country or region, high seasonality for incidence of active disease, and evidence that low standards of hygiene predispose to suffering of the disease. Key data issues include low levels of reporting, potential misdiagnosis, and scarce documentation on prevalence of asymptomatic infections. Currently available data most likely underestimates the magnitude of the disease burden. More effort is needed in order to refine accuracy of data currently being reported. A better characterization of the epidemiology of yaws globally is likely to positively impact on planning and implementation of yaws eradication.Keywords: eradication, Treponema pertenue, endemic countries, prevalence

  4. [Genetic epidemiology of schizophrenia in the population of Tomsk Oblast. Dependence of parameters of the occurrence of schizophrenia among relatives on the method of proband sample formation]. (United States)

    Ritsner, M S; Karas', S I; Sherina, O L; Boiarintseva, I G; Gutkevich, E V


    The program of genetic-epidemiological study of schizophrenia in five districts of the Tomsk region is presented. According to standardized methods, 610 diagnosed patients (epidemiological register) were examined, 74.1% of them being at random registered as probands (452 families of the epidemiological sample). 229 probands of non-epidemiological sample were registered in psychiatric hospitals. Schizophrenia occurrence parameters among first-degree relatives of probands of the non-epidemiological sample were regularly overestimated, as compared to the epidemiological sample. The methodical sources of contradictions in clinico-genealogical studies are discussed; the conclusion about representativeness+ of the probands' epidemiological sample is made.

  5. Epidemiology in Ethiopia 200 years after John Snow's birth. (United States)

    Enquselassie, Fikre


    The year 2013 marks exactly 200 years since John Snow, known as the father of modern epidemiology, was born. In 19th century, epidemiologists like John Snow, concentrated almost entirely upon infectious diseases of humans measuring the burden of disease, describing pattern and attempting to understand the transmission dynamics. During the second half of the 20th century; big changes occurred so that epidemiologists in the developed world started to use systematized approaches to investigate the etiologies, conditions and to evaluate interventions through different study designs. However, the situation in the developing world is not the same as the rest of the world. Even 200 years after Snow's birth, epidemiological capacity is lowest in Africa. This article attempts to describe that Ethiopia is not exceptional. In the past few decades, there have been some attempts to build capacity in the country by launching training programs in clinical epidemiology, general epidemiology and field epidemiology. However, not only few epidemiologists are trained, but, limited funding, high-teaching burdens, poor working conditions and low salaries are among important contributors for epidemiological brain drain in Ethiopia. Thus, strengthening learning opportunities and rewarding career paths are required to increase human resource capacity and retain skilled personnel in the field of epidemiology.

  6. Applied research in the ININ, solutions to challenges traced by the National Development Program; Investigacion aplicada en el ININ, soluciones a retos planteados por el programa Nacional de Desarrollo

    Energy Technology Data Exchange (ETDEWEB)

    Balcazar, M


    The National Program of Development 1991-1994 and the necessities expressed by the society as regards Energy, Ecology, Feeding, Industry and Health, they outline problems of inevitable solution. This articulates it presents the contribution to the solution of some of these problems that the investigators associated to the Management of Applied Investigation of the Inn provide by means of specific projects. (Author)

  7. Epidemiological effects of the A(H1N1)influenza vaccine immunization program on students%中学生接种甲型H1N1流感疫苗保护效果的评价

    Institute of Scientific and Technical Information of China (English)

    何寒青; 李倩; 何奔; 高雯洁; 姚凤燕; 蒋雪峰; 沈月根; 周建红; 陈恩富


    Objective To evaluate the epidemiological effects of vaccine immunization program related to A(H1N1)influenza in the middle school students.Methods Non-randomized clinical trial was designed to assess the A(H1N1)influenza vaccine on its efficacy.14883 students from 8 middle schools in Zhejiang province were recruited and classified into vaccinated or control groups,based on the status of immunization with A(H1N1)influenza vaccine.All subjects were followed up through one epidemic period(6 months)and the incidence rates of influenza-like illnesses,A(H1N1)influenza,and seasonal influenza in these two groups were compared to evaluate the efficacy of the vaccine.Results There were 6334 subjects in the vaccinated group and 8549 in the control group.7441.75 person-years were followed from these two groups.The incidence rate of A (H1N1)influenza in vaccinated group was 1.64‰ per person-year,lower than that of the control group.The rate difference(RD)was-1.64‰ per person-year(95% confidence interval value from-3.04‰ to-0.23‰ per person-year),and the difference was significant(P=0.010).The incidence rate of influenza-like illnesses in vaccinated group was 21.47‰ per person-year,lower than that of the control group(22.69‰ per person-year)and the diffefence was not significant(P>0.05).The incidence rate of B influenza in vaccinated group was 6.63‰ per person-year,higher than that of control group(7.02‰ per person-year)but the difference was not significant(P>0.05).Conclusion This vaccine demonstrated a good epidemiological effect against the A(H1N1)influenza virus infection,observed through a student-immunization program.The cross-protection effect against the influenza-like illnesses and other seasonal influenzas was not noticed in this study.%目的 了解中学生接种甲型H1NI流感疫苗的保护效果.方法 采用非随机对照临床试验方法,选择8所中学14 883名学生,分甲型H1N1流感疫苗接种组6334人,对照组(未接种)8549人,

  8. Applying the Context, Input, Process, Product Evaluation Model for Evaluation, Research, and Redesign of an Online Master's Program (United States)

    Sancar Tokmak, Hatice; Meltem Baturay, H.; Fadde, Peter


    This study aimed to evaluate and redesign an online master's degree program consisting of 12 courses from the informatics field using a context, input, process, product (CIPP) evaluation model. Research conducted during the redesign of the online program followed a mixed methodology in which data was collected through a CIPP survey,…

  9. Randomized Trial of an eLearning Program for Training Family Members of Children with Autism in the Principles and Procedures of Applied Behavior Analysis (United States)

    Jang, Jina; Dixon, Dennis R.; Tarbox, Jonathan; Granpeesheh, Doreen; Kornack, Julie; de Nocker, Yanicka


    Effective training of caregivers is an integral part of top-quality treatment programs for individuals with autism spectrum disorders (ASD). However, traditional caregiver training can be time consuming and costly. The development of Web-based electronic training programs (e.g., "eLearning") may extend training to rural areas, thereby…

  10. Epidemiological Concepts Regarding Disease Monitoring and Surveillance

    Directory of Open Access Journals (Sweden)

    Christensen Jette


    Full Text Available Definitions of epidemiological concepts regarding disease monitoring and surveillance can be found in textbooks on veterinary epidemiology. This paper gives a review of how the concepts: monitoring, surveillance, and disease control strategies are defined. Monitoring and surveillance systems (MO&SS involve measurements of disease occurrence, and the design of the monitoring determines which types of disease occurrence measures can be applied. However, the knowledge of the performance of diagnostic tests (sensitivity and specificity is essential to estimate the true occurrence of the disease. The terms, disease control programme (DCP or disease eradication programme (DEP, are defined, and the steps of DCP/DEP are described to illustrate that they are a process rather than a static MO&SS.

  11. Applied superconductivity

    CERN Document Server

    Newhouse, Vernon L


    Applied Superconductivity, Volume II, is part of a two-volume series on applied superconductivity. The first volume dealt with electronic applications and radiation detection, and contains a chapter on liquid helium refrigeration. The present volume discusses magnets, electromechanical applications, accelerators, and microwave and rf devices. The book opens with a chapter on high-field superconducting magnets, covering applications and magnet design. Subsequent chapters discuss superconductive machinery such as superconductive bearings and motors; rf superconducting devices; and future prospec

  12. Epidemiology of Brain Tumors. (United States)

    McNeill, Katharine A


    Brain tumors are the commonest solid tumor in children, leading to significant cancer-related mortality. Several hereditary syndromes associated with brain tumors are nonfamilial. Ionizing radiation is a well-recognized risk factor for brain tumors. Several industrial exposures have been evaluated for a causal association with brain tumor formation but the results are inconclusive. A casual association between the common mutagens of tobacco, alcohol, or dietary factors has not yet been established. There is no clear evidence that the incidence of brain tumors has changed over time. This article presents the descriptive epidemiology of the commonest brain tumors of children and adults.

  13. Epidemiological studies on syncope

    DEFF Research Database (Denmark)

    Ruwald, Martin Huth


    : 1) the use, validity and accuracy of the ICD-10 diagnosis of syncope R55.9 in the National Patient Registry for the use of this diagnosis in the epidemiology of syncope, 2) diagnostics used and etiology of a random selection of patients who had a discharge diagnosis of R55.9, 3) the incidence...... thesis demonstrated that the ICD-10 discharge diagnosis could reliably identify a cohort of patients admitted for syncope and that the discharge code carried a high number of unexplained cases despite use of numerous tests. The last studies showed that syncope is a common cause for hospital contact...

  14. Epidemiologia social Social epidemiology

    Directory of Open Access Journals (Sweden)

    Rita Barradas Barata


    Full Text Available Este artigo trata da emergência da epidemiologia social concomitantemente ao surgimento da epidemiologia como disciplina científica, destacando as condições teóricas e epistemológicas desse aparecimento. Em seguida são enfocadas as razões para o declínio dessa abordagem, assim como para seu ressurgimento na década de 60, no século XX. São apresentadas as diferentes correntes teóricas atualmente vigentes na epidemiologia social, destacando as características gerais e as limitações de cada uma delas. Especial atenção é dada às seguintes formulações: a eco-epidemiologia proposta por Mervin Susser, a teoria do capital social, a perspectiva do curso de vida, a teoria da produção social da doença e a teoria ecosocial elaborada por Nancy Krieger. O panorama traçado pretende demonstrar a vitalidade dessa abordagem, bem como indicar a diversidade de aspectos em seu interior. Para finalizar são apontados alguns dilemas e desafios.This paper reviews the latest trends in social epidemiology. It analyzes the emergence of epidemiology as a scientific discipline in the nineteenth century focusing on the main characteristics of the episteme of the period. This paper also analyzes the decline of the social approach in the beginning of the twentieth century and the resurgence of social interest in the sixties. The multiple approaches of social epidemiology currently adopted are commented. The study also emphasizes Susser's proposal of ecoepidemiology, describing its characteristics and pointing out limitations. Next, there is a discussion of the social capital theory and its potentialities for epidemiological studies. The life course perspective is also analyzed, mentioning its psychological and material versions. Latin America's social production of the health and disease process is presented along with an overview of Nancy Krieger's social ecoepidemiology. Finally, some dilemmas and challenges for the future are presented.

  15. Epidemiological Approaches to Metal Toxicology

    DEFF Research Database (Denmark)

    Grandjean, Philippe; Budtz-Jørgensen, Esben


    to their propensity to cause chronic or delayed toxicity, epidemiological studies of metal toxicity have focused on a wide variety of organ systems, subtle effects as well as mortality, and differences in susceptibility. Toxic metals often serve as paradigms of environmental and occupational toxicity....... For these reasons, this chapter highlights the fields within epidemiology that are most relevant to toxic metals and discusses where these substances serve to illustrate important epidemiological concepts. Chapter sections include subjects such as epidemiological terms, study design, study population, exposure...

  16. Molecular epidemiology: a multidisciplinary approach to understanding parasitic zoonoses. (United States)

    Traub, R J; Monis, P T; Robertson, I D


    Sound application of molecular epidemiological principles requires working knowledge of both molecular biological and epidemiological methods. Molecular tools have become an increasingly important part of studying the epidemiology of infectious agents. Molecular tools have allowed the aetiological agent within a population to be diagnosed with a greater degree of efficiency and accuracy than conventional diagnostic tools. They have increased the understanding of the pathogenicity, virulence, and host-parasite relationships of the aetiological agent, provided information on the genetic structure and taxonomy of the parasite and allowed the zoonotic potential of previously unidentified agents to be determined. This review describes the concept of epidemiology and proper study design, describes the array of currently available molecular biological tools and provides examples of studies that have integrated both disciplines to successfully unravel zoonotic relationships that would otherwise be impossible utilising conventional diagnostic tools. The current limitations of applying these tools, including cautions that need to be addressed during their application are also discussed.

  17. Abordagem das pesquisas em epidemiologia aplicada à gerontologia no Brasil: revisão da literatura em periódicos, entre 1995 e 2005 Approach to research in epidemiology applied to gerontology in Brazil: literature review of papers published between 1995 and 2005

    Directory of Open Access Journals (Sweden)

    Regina Bueno Ribas Pinto


    Full Text Available O presente estudo teve como objetivo realizar uma revisão da literatura de forma exploratória e descritiva, buscando determinar a abordagem das pesquisas realizadas em epidemiologia aplicada à gerontologia no Brasil. Com esse intuito, foi efetuado um levantamento bibliográfico por meio da utilização do banco de dados da biblioteca virtual do SciELO, do LILACS e do PubMed. A busca dos artigos foi feita, exclusivamente, em periódicos incluídos nestes bancos de dados, sendo realizada a procura em artigos publicados no período compreendido entre os anos de 1995 a 2005. Os resultados encontrados demonstraram uma grande diversidade e abrangência nos enfoques das pesquisas realizadas, com o predomínio de pesquisas que abordam a área de psicologia, estudos delimitados por regiões e doenças relevantes para o envelhecimento. Houve também, um aumento de forma considerável no número total de pesquisas que foram realizadas a partir do ano de 2001, com aproximadamente 18,4 % do total de artigos publicados encontrados somente no ano de 2005.The present study had the objective of carrying out an exploratory and descriptive literature review, to determine the approach of research in epidemiology applied to gerontology in Brazil. The literature review used the databases of SciELO virtual library, LILACS and PubMed, and only included papers published in journals indexed these databases, in the period between 1995 and 2005. The results found were greatly diversified and comprehensive in terms of research focus with an important prevalence of issues related to psychology and conditions associated to aging. There was also an increase in the amount of research starting from 2001, with approximately 18.4% of the total papers published in 2005.

  18. An Application of Epidemiological Modeling to Information Diffusion (United States)

    McCormack, Robert; Salter, William

    Messages often spread within a population through unofficial - particularly web-based - media. Such ideas have been termed "memes." To impede the flow of terrorist messages and to promote counter messages within a population, intelligence analysts must understand how messages spread. We used statistical language processing technologies to operationalize "memes" as latent topics in electronic text and applied epidemiological techniques to describe and analyze patterns of message propagation. We developed our methods and applied them to English-language newspapers and blogs in the Arab world. We found that a relatively simple epidemiological model can reproduce some dynamics of observed empirical relationships.

  19. Global epidemiology of sporotrichosis. (United States)

    Chakrabarti, Arunaloke; Bonifaz, Alexandro; Gutierrez-Galhardo, Maria Clara; Mochizuki, Takashi; Li, Shanshan


    Sporotrichosis is an endemic mycosis caused by the dimorphic fungus Sporothrix schenckii sensu lato. It has gained importance in recent years due to its worldwide prevalence, recognition of multiple cryptic species within the originally described species, and its distinctive ecology, distribution, and epidemiology across the globe. In this review, we describe the current knowledge of the taxonomy, ecology, prevalence, molecular epidemiology, and outbreaks due to S. schenckii sensu lato. Despite its omnipresence in the environment, this fungus has remarkably diverse modes of infection and distribution patterns across the world. We have delved into the nuances of how sporotrichosis is intimately linked to different forms of human activities, habitats, lifestyles, and environmental and zoonotic interactions. The purpose of this review is to stimulate discussion about the peculiarities of this unique fungal pathogen and increase the awareness of clinicians and microbiologists, especially in regions of high endemicity, to its emergence and evolving presentations and to kindle further research into understanding the unorthodox mechanisms by which this fungus afflicts different human populations.

  20. The Epidemiology of Sarcopenia. (United States)

    Dodds, Richard Matthew; Roberts, Helen Clare; Cooper, Cyrus; Sayer, Avan Aihie


    The aim of this review is to describe the epidemiology of sarcopenia, specifically prevalence, health outcomes, and factors across the life course that have been linked to its development. Sarcopenia definitions involve a range of measures (muscle mass, strength, and physical performance), which tend to decline with age, and hence sarcopenia becomes increasingly prevalent with age. Less is known about prevalence in older people in hospital and care homes, although it is likely to be higher than in community settings. The range of measures used, and the cutpoints suggested for each, presents a challenge for comparing prevalence estimates between studies. The importance of sarcopenia is highlighted by the range of adverse health outcomes that strength and physical performance (and to a lesser extent, muscle mass) have been linked to. This is shown most strikingly by the finding of increased all-cause mortality rates among those with weaker grip strength and slower gait speed. A life course approach broadens the window for our understanding of the etiology of sarcopenia and hence the potential intervention. An example is physical activity, with increased levels across midadulthood appearing to increase muscle mass and strength in early old age. Epidemiologic studies will continue to make an important contribution to our understanding of sarcopenia and possible avenues for intervention and prevention.

  1. Clinical Epidemiology Of Stroke

    Directory of Open Access Journals (Sweden)

    Nagaraja D


    Full Text Available Stroke is a huge public health problem because of its high morbidity and disability. The epidemiology of stroke is of relevance to construct practical paradigms to tackle this major health issue in the community. Recent data have shown that about 72-86% of strokes are ischemic, 9-18% are due to hemorrhage (intracerebral of subarachnoid and the rest are undefined. The risk factors for stroke are multiple and combined. At present, stroke is no more considered as unavoidable and untreatable. It is an emergency and specialized units and teams improve outcome and lower costs. Death related to stroke is declining in many countries and in both sexes. This decrease in multifactorial. The detection and more effective treatment of hypertension may play an important factor, as well as the improved medical care and improvement in diagnostic procedures. While stroke incidence appears stable and stroke mortality is slowly declining, the absolute magnitude of stroke is likely to grow over the next 30 years. as the population ages, the absolute number of stroke victims and demands on healthcare and other support systems is likely to increase substantially in the future. Keeping this in perspective, this chapter shall focus on the epidemiology of stroke in the world and in Indian, in particular.

  2. 13 CFR 124.110 - Do Native Hawaiian Organizations have any special rules for applying to the 8(a) BD program? (United States)


    ...) BD program as its primary SIC code. (d) SBA does not deem an individual involved in the management or...: (i) The technical and managerial experience and competence of the individual(s) who will manage...

  3. Applied mathematics

    CERN Document Server

    Logan, J David


    Praise for the Third Edition"Future mathematicians, scientists, and engineers should find the book to be an excellent introductory text for coursework or self-study as well as worth its shelf space for reference." -MAA Reviews Applied Mathematics, Fourth Edition is a thoroughly updated and revised edition on the applications of modeling and analyzing natural, social, and technological processes. The book covers a wide range of key topics in mathematical methods and modeling and highlights the connections between mathematics and the applied and nat

  4. The new epidemiology of nephrolithiasis. (United States)

    Shoag, Jonathan; Tasian, Greg E; Goldfarb, David S; Eisner, Brian H


    Historically nephrolithiasis was considered a disease of dehydration and abnormal urine composition. However, over the past several decades, much has been learned about the epidemiology of this disease and its relation to patient demographic characteristics and common systemic diseases. Here we review the latest epidemiologic studies in the field.

  5. Epidemiology of infections in women. (United States)

    Risser, Jan M H; Risser, William L; Risser, Amanda L


    This article describes the epidemiologic profiles of sexually transmitted infections seen in US women. We present a brief description of the infectious agent, describe the epidemiology of the infection among women in terms of race/ethnicity and age (if those data are available), and present what is known about the behavioral risk factors associated with acquisition.

  6. Applied Enzymology. (United States)

    Manoharan, Asha; Dreisbach, Joseph H.


    Describes some examples of chemical and industrial applications of enzymes. Includes a background, a discussion of structure and reactivity, enzymes as therapeutic agents, enzyme replacement, enzymes used in diagnosis, industrial applications of enzymes, and immobilizing enzymes. Concludes that applied enzymology is an important factor in…

  7. Economic and epidemiological evalution of possible salmonella control strategies in dairy cattle

    NARCIS (Netherlands)

    Bergevoet, R.H.M.; Schaik, van G.; Veling, J.; Backus, G.B.C.; Franken, P.


    This paper presents an analysis of a Salmonella control program for Dutch dairy herds. Salmonella control strategies were evaluated using a computer-based model consisting of an epidemiological module and an economics module. The epidemiological module is a state transition model of the infectivity

  8. Applying social marketing principles to understand the effects of the radio diaries program in reducing HIV/AIDS stigma in Malawi. (United States)

    Rimal, Rajiv N; Creel, Alisha H


    Relatively little is known about the extent to which health campaigns can play a constructive role in reducing HIV/AIDS-related stigma. The Malawi Radio Diaries is a program in which HIV-positive men and women openly discuss day-to-day events in their lives with the goal of reducing stigma in the population. Adopting a social marketing perspective, we analyze the various components of the Radio Diaries program in terms of three of the "Four P's": product (stigma reduction), place (radio), and promotion (the program itself). We first investigated the important dimensions of stigma and then developed a model to test the demographic and psychosocial correlates of these dimensions. A midterm household survey was then used to determine the relationship between exposure to the Radio Diaries program and stigma. In multivariate analyses, lower education and knowledge were associated with stronger beliefs that persons living with HIV should be isolated from others. Exposure to the Radio Diaries program did not have a main-effect on stigma, but there was a significant interaction between exposure and efficacy to reduce number of partners such that there was little difference in stigma by exposure level for those with low efficacy, but a significant difference by exposure level for those with high efficacy. Findings are discussed in terms of social marketing principles.

  9. Cancer epidemiology of woodworking. (United States)

    Mohtashamipur, E; Norpoth, K; Lühmann, F


    The literature published between 1965 and 1989 on the cancer epidemiology of woodworking in furniture industries and carpentry shops in 17 countries is reviewed. Included are some unpublished data obtained through personal communication with epidemiologists or collected from doctoral dissertations. Of 5,785 cases with sino-nasal cancers, about 23% were found to be woodworkers. Dusty jobs, especially wood processing using high-speed machines, are mainly associated with the enhanced incidence of nasal adenocarcinomas. The latency periods of the latter tumors ranged from 7 to 69 years in five European countries. A variety of neoplasias of the respiratory, digestive, and urinary tracts as well as the hemopoietic and lymphatic systems, including Hodgkin's disease are reported to be significantly associated with occupational exposure to wood dust. These data suggest that the exposure to some types of wood dust might cause a systemic rather than local neoplastic disorder.

  10. The Epidemiology of Sarcoma

    Directory of Open Access Journals (Sweden)

    Burningham Zachary


    Full Text Available Abstract Sarcomas account for over 20% of all pediatric solid malignant cancers and less than 1% of all adult solid malignant cancers. The vast majority of diagnosed sarcomas will be soft tissue sarcomas, while malignant bone tumors make up just over 10% of sarcomas. The risks for sarcoma are not well-understood. We evaluated the existing literature on the epidemiology and etiology of sarcoma. Risks for sarcoma development can be divided into environmental exposures, genetic susceptibility, and an interaction between the two. HIV-positive individuals are at an increased risk for Kaposi’s sarcoma, even though HHV8 is the causative virus. Radiation exposure from radiotherapy has been strongly associated with secondary sarcoma development in certain cancer patients. In fact, the risk of malignant bone tumors increases as the cumulative dose of radiation to the bone increases (p for trend

  11. [Epidemiology of urinary lithiasis]. (United States)

    Joual, A; Rais, H; Rabii, R; el Mrini, M; Benjelloun, S


    The objective of this study was to analyse the epidemiological profile of urinary stones based on one thousand cases observed in our institution over a 10-year period. The mean age of the patients was 45 years and two-thirds of patients were males. The kidney was the commonest site of stones, in 57.8% of cases. The stone was radiopaque in 86.4% of cases and was a staghorn calculus in 12.2% of cases. An associated renal malformation was observed in 10.4% of cases. Urinary stones is therefore a common disease, essentially observed in a young population and characterized by recurrence. It therefore constitutes a public health problem and prevention consists of detecting recurrences and treating stone-inducing factors.

  12. Epidemiology of gliomas. (United States)

    Ostrom, Quinn T; Gittleman, Haley; Stetson, Lindsay; Virk, Selene M; Barnholtz-Sloan, Jill S


    Gliomas are the most common type of primary intracranial tumors. Some glioma subtypes cause significant mortality and morbidity that are disproportionate to their relatively rare incidence. A very small proportion of glioma cases can be attributed to inherited genetic disorders. Many potential risk factors for glioma have been studied to date, but few provide explanation for the number of brain tumors identified. The most significant of these factors includes increased risk due to exposure to ionizing radiation, and decreased risk with history of allergy or atopic disease. The potential effect of exposure to cellular phones has been studied extensively, but the results remain inconclusive. Recent genomic analyses, using the genome-wide association study (GWAS) design, have identified several inherited risk variants that are associated with increased glioma risk. The following chapter provides an overview of the current state of research in the epidemiology of intracranial glioma.

  13. Epidemiology of acne vulgaris. (United States)

    Bhate, K; Williams, H C


    Despite acne being an almost universal condition in younger people, relatively little is known about its epidemiology. We sought to review what is known about the distribution and causes of acne by conducting a systematic review of relevant epidemiological studies. We searched Medline and Embase to the end of November 2011. The role of Propionibacterium acnes in pathogenesis is unclear: antibiotics have a direct antimicrobial as well as an anti-inflammatory effect. Moderate-to-severe acne affects around 20% of young people and severity correlates with pubertal maturity. Acne may be presenting at a younger age because of earlier puberty. It is unclear if ethnicity is truly associated with acne. Black individuals are more prone to postinflammatory hyperpigmentation and specific subtypes such as 'pomade acne'. Acne persists into the 20s and 30s in around 64% and 43% of individuals, respectively. The heritability of acne is almost 80% in first-degree relatives. Acne occurs earlier and is more severe in those with a positive family history. Suicidal ideation is more common in those with severe compared with mild acne. In the U.S.A., the cost of acne is over 3 billion dollars per year in terms of treatment and loss of productivity. A systematic review in 2005 found no clear evidence of dietary components increasing acne risk. One small randomized controlled trial showed that low glycaemic index (GI) diets can lower acne severity. A possible association between dairy food intake and acne requires closer scrutiny. Natural sunlight or poor hygiene are not associated. The association between smoking and acne is probably due to confounding. Validated core outcomes in future studies will help in combining future evidence.

  14. Epidemiology of visceral leishmaniasis

    Directory of Open Access Journals (Sweden)

    Ready PD


    Full Text Available Paul D ReadyDisease Control Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UKAbstract: Leishmania species are the causative agents of leishmaniasis, a neglected tropical disease. These parasitic protozoans are usually transmitted between vertebrate hosts by the bite of blood sucking female phlebotomine sand flies. This review focuses on the two parasites causing most human visceral leishmaniasis (VL, which leads to substantial health problems or death for up to 400,000 people per year. Except for travel cases, Leishmania donovani infections are restricted to the (sub-tropics of Asia and Africa, where transmission is mostly anthroponotic, while Leishmania infantum occurs in the drier parts of Latin America as well as in the Mediterranean climate regions of the Old World, with the domestic dog serving as the main reservoir host. The prevalence of VL caused by L. infantum has been declining where living standards have improved. In contrast, infections of L. donovani continue to cause VL epidemics in rural areas on the Indian subcontinent and in East Africa. The current review compares and contrasts these continental differences and suggests priorities for basic and applied research that might improve VL control. Transmission cycles, pathogenesis, diagnosis, treatment and prognosis, prevention (including vector control, surveillance, transmission modeling, and international control efforts are all reviewed. Most case detection is passive, and so routine surveillance does not usually permit accurate assessments of any changes in the incidence of VL. Also, it is not usually possible to estimate the human inoculation rate of parasites by the sand fly vectors because of the limitations of survey methods. Consequently, transmission modeling rarely passes beyond the proof of principle stage, and yet it is required to help develop risk factor analysis for control programs. Anthroponotic VL

  15. Applied dynamics

    CERN Document Server

    Schiehlen, Werner


    Applied Dynamics is an important branch of engineering mechanics widely applied to mechanical and automotive engineering, aerospace and biomechanics as well as control engineering and mechatronics. The computational methods presented are based on common fundamentals. For this purpose analytical mechanics turns out to be very useful where D’Alembert’s principle in the Lagrangian formulation proves to be most efficient. The method of multibody systems, finite element systems and continuous systems are treated consistently. Thus, students get a much better understanding of dynamical phenomena, and engineers in design and development departments using computer codes may check the results more easily by choosing models of different complexity for vibration and stress analysis.

  16. Multi-Strain Deterministic Chaos in Dengue Epidemiology, A Challenge for Computational Mathematics (United States)

    Aguiar, Maíra; Kooi, Bob W.; Stollenwerk, Nico


    Recently, we have analysed epidemiological models of competing strains of pathogens and hence differences in transmission for first versus secondary infection due to interaction of the strains with previously aquired immunities, as has been described for dengue fever, known as antibody dependent enhancement (ADE). These models show a rich variety of dynamics through bifurcations up to deterministic chaos. Including temporary cross-immunity even enlarges the parameter range of such chaotic attractors, and also gives rise to various coexisting attractors, which are difficult to identify by standard numerical bifurcation programs using continuation methods. A combination of techniques, including classical bifurcation plots and Lyapunov exponent spectra has to be applied in comparison to get further insight into such dynamical structures. Especially, Lyapunov spectra, which quantify the predictability horizon in the epidemiological system, are computationally very demanding. We show ways to speed up computations of such Lyapunov spectra by a factor of more than ten by parallelizing previously used sequential C programs. Such fast computations of Lyapunov spectra will be especially of use in future investigations of seasonally forced versions of the present models, as they are needed for data analysis.

  17. Comparative review of three cost-effectiveness models for rotavirus vaccines in national immunization programs; a generic approach applied to various regions in the world

    Directory of Open Access Journals (Sweden)

    Tu Hong-Anh


    Full Text Available Abstract Background This study aims to critically review available cost-effectiveness models for rotavirus vaccination, compare their designs using a standardized approach and compare similarities and differences in cost-effectiveness outcomes using a uniform set of input parameters. Methods We identified various models used to estimate the cost-effectiveness of rotavirus vaccination. From these, results using a standardized dataset for four regions in the world could be obtained for three specific applications. Results Despite differences in the approaches and individual constituting elements including costs, QALYs Quality Adjusted Life Years and deaths, cost-effectiveness results of the models were quite similar. Differences between the models on the individual components of cost-effectiveness could be related to some specific features of the respective models. Sensitivity analysis revealed that cost-effectiveness of rotavirus vaccination is highly sensitive to vaccine prices, rotavirus-associated mortality and discount rates, in particular that for QALYs. Conclusions The comparative approach followed here is helpful in understanding the various models selected and will thus benefit (low-income countries in designing their own cost-effectiveness analyses using new or adapted existing models. Potential users of the models in low and middle income countries need to consider results from existing studies and reviews. There will be a need for contextualization including the use of country specific data inputs. However, given that the underlying biological and epidemiological mechanisms do not change between countries, users are likely to be able to adapt existing model designs rather than developing completely new approaches. Also, the communication established between the individual researchers involved in the three models is helpful in the further development of these individual models. Therefore, we recommend that this kind of comparative study

  18. Professionally significant psychophysiological qualities of information logical group of specialties at implementation of the experimental program of professionally applied physical training of students

    Directory of Open Access Journals (Sweden)

    Ostapenko Y.O.


    Full Text Available Purpose: to improve vocational and applied physical training of students of economics. Material: the pedagogical study involved 72 male students (aged 19-20 years. Results: job study was conducted. Defined professionally significant neurobehavioral performance of students of information logical group. Matched professionally applied exercises for their development. The results showed that in the process of purposeful muscle activity improved mechanisms of regulation of neural processes, adaptive changes occur that affect the temporal parameters of sensorimotor motor responses. A comparative analysis of the psychophysiological indicators of students of the control and experimental groups was done. Conclusions: it was found that matched professionally applied exercises positively affect the development of psycho-physiological qualities of students information and logical group of specialties.

  19. Chemical research projects office functions accomplishments programs. [applied research in the fields of polymer chemistry and polymeric composites with emphasis on fire safety (United States)

    Heimbuch, A. H.; Parker, J. A.


    Basic and applied research in the fields of polymer chemistry, polymeric composites, chemical engineering, and biophysical chemistry is summarized. Emphasis is placed on fire safety and human survivability as they relate to commercial and military aircraft, high-rise buildings, mines and rapid transit transportation. Materials systems and other fire control systems developed for aerospace applications and applied to national domestic needs are described along with bench-scale and full-scale tests conducted to demonstrate the improvements in performance obtained through the utilization of these materials and fire control measures.

  20. Epidemiological and Economic Burden of Pneumococcal Disease in Canadian Children

    Directory of Open Access Journals (Sweden)

    Geneviève Petit


    Full Text Available BACKGROUND: With the arrival of a new conjugate pneumococcal vaccine, it is important to estimate the burden of pneumococcal diseases in Canadian children. The epidemiological data and the economic cost of these diseases are crucial elements in evaluating the relevance of a vaccination program.

  1. Molecular epidemiology of giardiasis. (United States)

    Cacciò, Simone M; Ryan, Una


    Giardia duodenalis is a widespread parasite of mammalian species, including humans. Due to its invariant morphology, investigation on aspects such as host specificity and transmission patterns requires a direct genetic characterization of cysts/trophozoites from host samples. A number of molecular assays have been developed to help unravel the complex epidemiology of this infection. A coherent picture has emerged from those studies, indicating the existence of seven genetic groups (or assemblages), two of which (A and B) are found in both humans and animals, whereas the remaining five (C-G) are host-specific. Sequence-based surveys have identified a number of genotypes within assemblages A and B in animal species, some of which may have zoonotic potential. Recently, however, molecular approaches have been complicated by the recognition of intra-isolate sequence heterogeneity (i.e., "mixed templates", that affects identification of subtypes within each assemblage), and by the unreliable assignment of isolates to G. duodenalis assemblages generated by different genetic markers. This raises concerns about previous interpretation of genotyping data, especially when single genetic markers have been used. The mechanisms that may be responsible for these findings, including allelic sequence heterozygosity and meiotic recombination, are discussed.

  2. Microtia: epidemiology and genetics. (United States)

    Luquetti, Daniela V; Heike, Carrie L; Hing, Anne V; Cunningham, Michael L; Cox, Timothy C


    Microtia is a congenital anomaly of the ear that ranges in severity from mild structural abnormalities to complete absence of the ear, and can occur as an isolated birth defect or as part of a spectrum of anomalies or a syndrome. Microtia is often associated with hearing loss and patients typically require treatment for hearing impairment and surgical ear reconstruction. The reported prevalence varies among regions, from 0.83 to 17.4 per 10,000 births, and the prevalence is considered to be higher in Hispanics, Asians, Native Americans, and Andeans. The etiology of microtia and the cause of this wide variability in prevalence are poorly understood. Strong evidence supports the role of environmental and genetic causes for microtia. Although some studies have identified candidate genetic variants for microtia, no causal genetic mutation has been confirmed. The application of novel strategies in developmental biology and genetics has facilitated elucidation of mechanisms controlling craniofacial development. In this paper we review current knowledge of the epidemiology and genetics of microtia, including potential candidate genes supported by evidence from human syndromes and animal models. We also discuss the possible etiopathogenesis in light of the hypotheses formulated to date: Neural crest cells disturbance, vascular disruption, and altitude.

  3. Epidemiology of delayed ejaculation. (United States)

    Di Sante, Stefania; Mollaioli, Daniele; Gravina, Giovanni Luca; Ciocca, Giacomo; Limoncin, Erika; Carosa, Eleonora; Lenzi, Andrea; Jannini, Emmanuele A


    A large body of literature on diminished ejaculatory disorders has been generated without the use of a clear diagnostic definition. Many studies have not distinguished between the orgasm and ejaculation disorders leading to doubtful results. Delayed ejaculation (DE) is one of the diminished ejaculatory disorders, which range from varying delays in ejaculatory latency to a complete inability to ejaculate. The present review is aimed at providing a comprehensive overview of the current knowledge on the definition and epidemiology of diminished ejaculatory disorders. We focus on the acquired diseases, such as benign prostatic hyperplasia (BPH) and specific drug regimens that may cause an iatrogenic form of ejaculatory disorder. In addition, the impact of aging is discussed since the prevalence of DE appears to be moderately but positively related to age. Finally, we also focus on the importance of the hormonal milieu on male ejaculation. To date, evidence on the endocrine control of ejaculation is derived from small clinical trials, but the evidence suggests that hormones modulate the ejaculatory process by altering its overall latency.

  4. Radiobiology and Epidemiology

    Energy Technology Data Exchange (ETDEWEB)

    Desaintes, C; Holmstock, L


    The main objectives of research in the field of radiobiology and epidemiology performed at the Belgian Nuclear Research Centre SCK-CEN are: (1) to study cancer mortality in nuclear workers in Belgium and to co-ordinate the Belgian contribution to the 'International Collaborative Study of Cancer Risk among Radiation Workers in the Nuclear Industry'; (2) to elucidate the molecular basis of individual susceptibility to ionizing radiation in mammalian embryo during the early phases of its development; (3) to assess the genetic risk of maternal exposure to ionizing radiation; (4) to elucidate the cellular mechanisms leading to brain damage after prenatal irradiation; (5) to monitor the early variations of gene expression induced by ionising radiation and cytokines; (6) to evaluate the use of cytokines and natural substances for improving radiotherapy protocols; (6) to advise authorities and to provide the general population with adequate information concerning the health risk arising from radiation exposure. Progress and major achievements in these topical areas in 2000 are reported.

  5. Epidemiology of gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Katherine D Crew; Alfred I Neugut


    The incidence and mortality of gastric cancer have fallen dramatically in US and elsewhere over the past several decades. Nonetheless, gastric cancer remains a major public health issue as the fourth most common cancer and the second leading cause of cancer death worldwide. Demographic trends differ by tumor location and histology. While there has been a marked decline in distal, intestinal type gastric cancers, the incidence of proximal, diffuse type adenocarcinomas of the gastric cardia has been increasing, particularly in the Western countries. Incidence by tumor sub-site also varies widely based on geographic location, race, and socioeconomic status. Distal gastric cancer predominates in developing countries, among blacks, and in lower socioeconomic groups, whereas proximal tumors are more common in developed countries, among whites, and in higher socio-economic classes. Diverging trends in the incidence of gastric cancer by tumor location suggest that they may represent two diseases with different etiologies. The main risk factors for distal gastric cancer include Helicobacter pylori (H pylori) infection and dietary factors, whereas gastroesophageal reflux disease and obesity play important roles in the development of proximal stomach cancer. The purpose of this review is to examine the epidemiology and risk factors of gastric cancer, and to discuss strategies for primary prevention.

  6. Epidemiology of severe trauma. (United States)

    Alberdi, F; García, I; Atutxa, L; Zabarte, M


    Major injury is the sixth leading cause of death worldwide. Among those under 35 years of age, it is the leading cause of death and disability. Traffic accidents alone are the main cause, fundamentally in low- and middle-income countries. Patients over 65 years of age are an increasingly affected group. For similar levels of injury, these patients have twice the mortality rate of young individuals, due to the existence of important comorbidities and associated treatments, and are more likely to die of medical complications late during hospital admission. No worldwide, standardized definitions exist for documenting, reporting and comparing data on severely injured trauma patients. The most common trauma scores are the Abbreviated Injury Scale (AIS), the Injury Severity Score (ISS) and the Trauma and Injury severity Score (TRISS). Documenting the burden of injury also requires evaluation of the impact of post-trauma impairments, disabilities and handicaps. Trauma epidemiology helps define health service and research priorities, contributes to identify disadvantaged groups, and also facilitates the elaboration of comparable measures for outcome predictions.


    Directory of Open Access Journals (Sweden)

    Giorgia Sulis


    Full Text Available Tuberculosis (TB is a major public health concern worldwide: despite a regular, although slow, decline in incidence over the last decade, as many as 8.6 million new cases and 1.3 million deaths were estimated to have occurred in 2012. TB is by all means a poverty-related disease, mainly affecting the most vulnerable populations in the poorest countries. The presence of multidrug-resistant strains of M. tuberculosis in most countries, with some where prevalence is high, is among the major challenges for TB control, which may hinder recent achievements especially in some settings. Early TB case detection especially in resource-constrained settings and in marginalized groups remains a challenge, and about 3 million people are estimated to remain undiagnosed or not notified and untreated. The World Health Organization (WHO has recently launched the new global TB strategy for the “post-2015 era” aimed at “ending the global TB epidemic” by 2035, based on the three pillars that emphasize patient-centred TB care and prevention, bold policies and supportive systems, and intensified research and innovation. This paper aims to provide an overview of the global TB epidemiology as well as of the main challenges that must be faced to eliminate the disease as a public health problem everywhere.

  8. Modeling Corporate Epidemiology

    CERN Document Server

    Waber, Benjamin; Cebrian, Manuel; Crane, Riley; Danon, Leon; Pentland, Alex


    Corporate responses to illness is currently an ad-hoc, subjective process that has little basis in data on how disease actually spreads at the workplace. Additionally, many studies have shown that productivity is not an individual factor but a social one: in any study on epidemic responses this social factor has to be taken into account. The barrier to addressing this problem has been the lack of data on the interaction and mobility patterns of people in the workplace. We have created a wearable Sociometric Badge that senses interactions between individuals using an infra-red (IR) transceiver and proximity using a radio transmitter. Using the data from the Sociometric Badges, we are able to simulate diseases spreading through face-to-face interactions with realistic epidemiological parameters. In this paper we construct a curve trading off productivity with epidemic potential. We are able to take into account impacts on productivity that arise from social factors, such as interaction diversity and density, wh...

  9. Pemphigus: Epidemiology and Pathogenesis

    Directory of Open Access Journals (Sweden)

    Yelda Karıncaoğlu


    Full Text Available Pemphigus, a group of bullous diseases affecting the oral mucosa and the skin, is caused by antibody-mediated autoimmune reaction to desmogleins (Dsg, desmosomal transmembrane glycoproteins, leading to acantholysis. Pemphigus has a worldwide distribution but the incidence in patients of Jewish origin is higher. The disease has a peak incidence of occurrence between the 4th and 6th decades. While various environmental factors have been implicated as triggering agents, HLA association is probably the most important predisposing factor. Pemphigus, is caused by antibody-mediated autoimmune reaction to desmosomal cadherins, Dsg1, and Dsg3. Recent molecular studies have shown that acantholysis can occur also in the presence of antibodies against 9a nicotinic acetylcholine receptor. Pemphigus is currently divided into three distinct varieties, i.e., pemphigus vulgaris (PV, pemphigus foliaceus (PF and other variants of pemphigus, depending on clinical features, the level of separation in the epidermis, and immunologic characteristics of auto-antigens. Blistering pathogenesis differ for each of the types of pemphigus. PV is characterized by IgG autoantibodies against Dsg 3, whereas the target of PF is Dsg1, although about 50% of PV patients also have Dsg1 autoantibodies. Lesion distribution is related to the location of the antigen (Dgs 3 and/or Dgs 1 in the epithelium and specific autoantibody production. This article reviews the epidemiology and pathogenesis of pemphigus.

  10. Metabolomics and Epidemiology Working Group (United States)

    The Metabolomics and Epidemiology (MetEpi) Working Group promotes metabolomics analyses in population-based studies, as well as advancement in the field of metabolomics for broader biomedical and public health research.

  11. Rosacea: current state of epidemiology. (United States)

    Tan, Jerry; Berg, Mats


    Case definitions are critical in epidemiologic research. However, modern disease indicators must now consider complex data from gene-based research along with traditional clinical parameters. Rosacea is a skin disorder with multiple signs and symptoms. In individuals, these features may be multiple or one may predominate. While studies on the epidemiology of rosacea have previously been sparse, there has been a recent increase in research activity. A broader body of epidemiological information that includes a greater variety of countries beyond Northern Europe and general population-based demographics is needed. As there are operational issues in current case definitions of rosacea subtypes--rationalization and standardization--universal consistent applications in future research is also imperative. Further improvement in disease definition combining new research information along with clinical pragmatism should increase the accuracy of rosacea case ascertainment and facilitate further epidemiological research.

  12. Epidemiologic view of phenylketonuria (PKU in Latinamerica

    Directory of Open Access Journals (Sweden)

    Gustavo JC Borrajo


    Phenylketonuria newborn screening programs vary among different Latin American countries; each one has its own history; quality standards, newborn population covered and the mandatory legislation of newborn screening. Epidemiological knowledge on phenylketonuria of this region is imprecise due to the lack of national statistic registries, thus avoiding an objective assessment of population coverage and disease incidence; therefore available data is obtained from isolated observations. Analysis of phenylketonuria and hyperphenylalaninemia based on available information of several Latin American newborn screening programs shows mean incidence values of 1: 23,518 and 1: 20,759 respectively; however, individual analysis of incidence by country indicates that phenylketonuria ranges between 1:12,473 and 1:161,748 live newborns.

  13. Sociocultural epidemiology: an essential approach.

    Directory of Open Access Journals (Sweden)

    Paul Hersch-Martínez


    Full Text Available The necessity of an inclusive epidemiological approach, capable to attend the diverse dimensions involved in health damage as a reflective phenomenon of society is analyzed. The range of perspectives involved requires an inclusive methodological scope and applicative channels, in order to deal with sanitary realities systematically related to culture and social organization. Some constitutive elements of sociocultural epidemiology are underlined, shaping an operative proposal that can enhance the relationship between disciplines and sectors regarding specific outstanding public health problems.

  14. Asociación entre la epidemiología de la rabia canina, la organización del programa de rabia y las condiciones socio-económicas en Colombia. Estudio ecológico. / Association between canine rabies epidemiology, the organization of rabies national control program and the socio-economic conditions in Colombia. Ecologic study



    Se realizó un estudio epidemiológico para estimar la asociación entre la epidemiología de la rabia canina y las condiciones socio-económicas y del programa de rabia nacional en Colombia. Se observó una tasa de incidencia de 0,36 por cada 100.000 perros entre el 2001 y 2006. Se calculó un subregistro de la rabia canina del 87% causado por una deficiente vigilancia en la mayoría de los departamentos y distritos. Para la estimación del subregistro de la enfermedad en perros se usó la tasa 1,81 x...

  15. An Evaluation of the Nonlinearity Correction Applied to Atmospheric Emitted Radiance Interferometer (AERI) Data Collected by the Atmospheric Radiation Measurement Program

    Energy Technology Data Exchange (ETDEWEB)

    Turner, D. D. [National Oceanic and Atmospheric Administration (NOAA), Boulder, CO (United States). Earth System Research Lab.; Knuteson, R. O. [Univ. of Wisconsin, Madison, WI (United States); Revercomb, H. E. [Univ. of Wisconsin, Madison, WI (United States); Dedecker, R. G. [Univ. of Wisconsin, Madison, WI (United States); Feltz, W. F. [Univ. of Wisconsin, Madison, WI (United States)


    Mercury Cadmium Telluride (MCT) detectors provide excellent sensitivity to infrared radiation and are used in passive infrared remote sensors such as the Atmospheric Emitted Radiance Interferometer (AERI). However, MCT detectors have a nonlinear response and thus this nonlinearity must be characterized and corrected to provide accurate infrared radiance observations. This paper discusses the significance of the nonlinearity correction applied to AERI data and its impacts on the parameters retrieved from the AERI spectra. It also evaluates the accuracy of the scheme used to determine the nonlinearity of the MCT detectors used in the Atmospheric Radiation Measurement (ARM) Program’s AERIs.

  16. Applying the milestones in an internal medicine residency program curriculum: a foundation for outcomes-based learner assessment under the next accreditation system. (United States)

    Lowry, Becky N; Vansaghi, Lisa M; Rigler, Sally K; Stites, Steven W


    In 2010, University of Kansas Medical Center internal medicine residency program leaders concluded that their competency-based curriculum and evaluation system was not sufficient to promote accurate assessment of learners' performance and needed revision to meet the requirements of the Accreditation Council for Graduate Medical Education (ACGME) Next Accreditation System (NAS). Evaluations of learners seldom referenced existing curricular goals and objectives and reflected an "everyone is exceptional, no one is satisfactory" view.The authors identified the American Board of Internal Medicine and ACGME's Developmental Milestones for Internal Medicine Residency Training as a published standard for resident development. They incorporated the milestones into templates, a format that could be modified for individual rotations. A milestones-based curriculum for each postgraduate year of training and every rotation was then created, with input from educational leaders within each division in the Department of Internal Medicine and with the support of the graduate medical education office.In this article, the authors share their implementation process, which took approximately one year, and discuss their current work to create a documentation system for direct observation of entrustable professional activities, with the aim of providing guidance to other programs challenged with developing an outcomes-based curriculum and assessment system within the time frame of the NAS.

  17. 1995 Annual epidemiologic surveillance report for Pantex Plant

    Energy Technology Data Exchange (ETDEWEB)



    This report provides a summary of epidemiologic surveillance data collected from the Pantex Plant from January 1, 1995 through December 31,1995. The data were collected by a coordinator at Pantex and submitted to the Epidemiologic Surveillance Data Center,located at Oak Ridge Institute for Science and Education, where quality control procedures and data analyses were carried out. The data presented apply only to Pantex. The main sections of the report are the same as in previous years; the 1995 report provides additional information describing the work force by age and occupational groups.

  18. Applied combustion

    Energy Technology Data Exchange (ETDEWEB)



    From the title, the reader is led to expect a broad practical treatise on combustion and combustion devices. Remarkably, for a book of modest dimension, the author is able to deliver. The text is organized into 12 Chapters, broadly treating three major areas: combustion fundamentals -- introduction (Ch. 1), thermodynamics (Ch. 2), fluid mechanics (Ch. 7), and kinetics (Ch. 8); fuels -- coal, municipal solid waste, and other solid fuels (Ch. 4), liquid (Ch. 5) and gaseous (Ch. 6) fuels; and combustion devices -- fuel cells (Ch. 3), boilers (Ch. 4), Otto (Ch. 10), diesel (Ch. 11), and Wankel (Ch. 10) engines and gas turbines (Ch. 12). Although each topic could warrant a complete text on its own, the author addresses each of these major themes with reasonable thoroughness. Also, the book is well documented with a bibliography, references, a good index, and many helpful tables and appendices. In short, Applied Combustion does admirably fulfill the author`s goal for a wide engineering science introduction to the general subject of combustion.

  19. Inquiring into Applying Object-Oriented Programming to Finite Element Program Design%有限元编程中应用面向对象编程技术的探讨

    Institute of Scientific and Technical Information of China (English)

    王伟; 刘德富


    采用面向对象编程技术(OOP),运用C++语言,描述了有限元程序的设计过程.针对有限元分析中的结点、单元和整个研究区域,建立了结点类、单元类和研究区域类分别负责管理,并提供了程序的部分实现代码.与传统Fortran语言编制的有限元程序相比,该法编制的程序执行速度快、维护简便、易于实现多种类型单元共存的情况,是解决大型有限元程序编制的有效方法.%The process of finite elements program design is described with C++ language and object-oriented programming(OOP).In the light of nodes,elements and the whole considered area at finite element analysis;the node class,element class and considered area class are established to be in charge of them respectively.Parts of the program codes are provided. Compared with finite element program with traditional Fortran language, the program with OOP has predominance of high speed in program running,convenient in maintenance and easily realizing coexisting of various kinds of elements. It is effective for large-scale finite element program design.

  20. Molecular Epidemiology for Vector Research on Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Hirotomo Kato


    Full Text Available Leishmaniasis is a protozoan disease caused by the genus Leishmania transmitted by female phlebotomine sand flies. Surveillance of the prevalence of Leishmania and responsive vector species in endemic and surrounding areas is important for predicting the risk and expansion of the disease. Molecular biological methods are now widely applied to epidemiological studies of infectious diseases including leishmaniasis. These techniques are used to detect natural infections of sand fly vectors with Leishmania protozoa and are becoming powerful tools due to their sensitivity and specificity. Recently, genetic analyses have been performed on sand fly species and genotyping using PCR-RFLP has been applied to the sand fly taxonomy. In addition, a molecular mass screening method has been established that enables both sand fly species and natural leishmanial infections to be identified simultaneously in hundreds of sand flies with limited effort. This paper reviews recent advances in the study of sand flies, vectors of leishmaniasis, using molecular biological approaches.

  1. Inquérito epidemiológico sobre teníase em população do programa saúde da família no município de Uberaba, MG Epidemiologic survery of teniasis in health and family program in Uberaba, MG

    Directory of Open Access Journals (Sweden)

    Flavia Maria Esteves


    Full Text Available Foi realizado inquérito para avaliar alguns aspectos epidemiológicos da teníase em 100.144 indivíduos do Programa Saúde da Família. Foram identificados 185 (0,2% indivíduos com antecedentes de teníase. Destes, 112 (60,5% receberam tratamento com praziquantel. Em 97 (86,6% dos casos, houve eliminação de proglotes que corresponderam a Taenia saginata e Taenia solium em 36 (37,1% e 4 (4,1%, respectivamente.An epidemiologic survey was carried out on 110,144 people from the Health Family Program to evaluate some Epidemiologic aspects of teniasis. Previous history of passing proglottides was registered in 185(0.2% of them, and 112 (60.5% received praziquantel. After this 97 (86.6% passed proglottides characterized as Taenia Saginata and Taenia Solium in 36 (37.1% and 4 (4.1% respectively.

  2. Epidemiology of hepatitis C in the middle east

    Directory of Open Access Journals (Sweden)

    Farahnaz Fallahian


    Full Text Available The epidemiology of hepatitis C virus (HCV infection is not well defined in the Middle East region. A review of the epidemiology and modes of transmission and spread of HCV infection in regions located in the Middle East, including Iran, Bahrain, Iraq, Oman, Qatar, Jordan, Kuwait, Saudi Arabia, United Arab Emirates, Cyprus, Sudan, Egypt, Pakistan, Syria, Turkey, Lebanon, Gaza Strip and West Bank, and Yemen, was undertaken. Public health strategies, well-programmed, population-based and certain HCV infection at-risk surveys, and transmission risk factors′ settings detection are insufficient in some countries of this region. Since significant diffe-rences in prevalence and epidemiology of HCV exist among the Middle East countries or even inside the countries, control strategies should take these differences into account.

  3. Comparison of two non-convex mixed-integer nonlinear programming algorithms applied to autoregressive moving average model structure and parameter estimation (United States)

    Uilhoorn, F. E.


    In this article, the stochastic modelling approach proposed by Box and Jenkins is treated as a mixed-integer nonlinear programming (MINLP) problem solved with a mesh adaptive direct search and a real-coded genetic class of algorithms. The aim is to estimate the real-valued parameters and non-negative integer, correlated structure of stationary autoregressive moving average (ARMA) processes. The maximum likelihood function of the stationary ARMA process is embedded in Akaike's information criterion and the Bayesian information criterion, whereas the estimation procedure is based on Kalman filter recursions. The constraints imposed on the objective function enforce stability and invertibility. The best ARMA model is regarded as the global minimum of the non-convex MINLP problem. The robustness and computational performance of the MINLP solvers are compared with brute-force enumeration. Numerical experiments are done for existing time series and one new data set.

  4. Enhancing the effectiveness of HIV/AIDS prevention programs targeted to unique population groups in Thailand: lessons learned from applying concepts of diffusion of innovation and social marketing. (United States)

    Svenkerud, P J; Singhal, A


    Diffusion of innovations theory and social marketing theory have been criticized for their limited applicability in influencing unique population groups (e.g., female commercial sex workers (CSWs) working in low-class brothels). This study investigated the applicability of these two theoretical frameworks in outreach efforts directed to unique populations at high risk for HIV/AIDS in Bangkok, Thailand. Further, this study examined Thai cultural characteristics that influence communication about HIV/AIDS prevention. The results suggest that certain concepts and strategies drawn from the two frameworks were used more or less by effective outreach programs, providing several policy-relevant lessons. Cultural constraints, such as the lack of visibility of the disease and traditional sexual practices, influenced communication about HIV/AIDS prevention.

  5. Morphometrics applied to medical entomology. (United States)

    Dujardin, Jean-Pierre


    Morphometrics underwent a revolution more than one decade ago. In the modern morphometrics, the estimate of size is now contained in a single variable reflecting variation in many directions, as many as there are landmarks under study, and shape is defined as their relative positions after correcting for size, position and orientation. With these informative data, and the corresponding software freely available to conduct complex analyses, significant biological and epidemiological features can be quantified more accurately. We discuss the evolutionary significance of the environmental impact on metric variability, mentioning the importance of concepts like genetic assimilation, genetic accommodation, and epigenetics. We provide examples of measuring the effect of selection on metric variation by comparing (unpublished) Qst values with corresponding (published) Fst. The primary needs of medical entomologists are to distinguish species, especially cryptic species, and to detect them where they are not expected. We explain how geometric morphometrics could apply to these questions, and where there are deficiencies preventing the approach from being utilized at its maximum potential. Medical entomologists in connection with control programs aim to identify isolated populations where the risk of reinfestation after treatment would be low ("biogeographical islands"). Identifying them can be obtained from estimating the number of migrants per generation. Direct assessment of movement remains the most valid approach, but it scores active movement only. Genetic methods estimating gene flow levels among interbreeding populations are commonly used, but gene flow does not necessarily mean the current flow of migrants. Methods using the morphometric variation are neither suited to evaluate gene flow, nor are they adapted to estimate the flow of migrants. They may provide, however, the information needed to create a preliminary map pointing to relevant areas where one could

  6. Introduction to the use of regression models in epidemiology. (United States)

    Bender, Ralf


    Regression modeling is one of the most important statistical techniques used in analytical epidemiology. By means of regression models the effect of one or several explanatory variables (e.g., exposures, subject characteristics, risk factors) on a response variable such as mortality or cancer can be investigated. From multiple regression models, adjusted effect estimates can be obtained that take the effect of potential confounders into account. Regression methods can be applied in all epidemiologic study designs so that they represent a universal tool for data analysis in epidemiology. Different kinds of regression models have been developed in dependence on the measurement scale of the response variable and the study design. The most important methods are linear regression for continuous outcomes, logistic regression for binary outcomes, Cox regression for time-to-event data, and Poisson regression for frequencies and rates. This chapter provides a nontechnical introduction to these regression models with illustrating examples from cancer research.

  7. Applied chemical engineering thermodynamics

    CERN Document Server

    Tassios, Dimitrios P


    Applied Chemical Engineering Thermodynamics provides the undergraduate and graduate student of chemical engineering with the basic knowledge, the methodology and the references he needs to apply it in industrial practice. Thus, in addition to the classical topics of the laws of thermodynamics,pure component and mixture thermodynamic properties as well as phase and chemical equilibria the reader will find: - history of thermodynamics - energy conservation - internmolecular forces and molecular thermodynamics - cubic equations of state - statistical mechanics. A great number of calculated problems with solutions and an appendix with numerous tables of numbers of practical importance are extremely helpful for applied calculations. The computer programs on the included disk help the student to become familiar with the typical methods used in industry for volumetric and vapor-liquid equilibria calculations.

  8. Fatty acid composition of soybean/sunflower mix oil, fish oil and butterfat applying the AOCS Ce 1j-07 method with a modified temperature program

    Directory of Open Access Journals (Sweden)

    Masson, L.


    Full Text Available Gas-Liquid Chromatography (GLC methods such as AOAC Fat in foods 966.06 (2005, AOCS Official Methods Ce 1h-05 (2005, Ce 1j-07 (2007, allow for analyzing the fatty acids (FAs in dietary fats using highly polar liquid phase capillary columns. However, there are still difficulties in completely separating butiric acid from solvent, FA critical pairs with similar polarity, conjugated linoleic acid (CLA isomers, and long chainpolyunsaturated FAs (LC-PUFAs. Therefore, the selection of the temperature program to be employed is important. This work aimed to improve the AOCS Ce 1j-07 Method for the FA composition of a mixture of soybean and sunflower oil, fish oil, and butterfat, using a modified temperature program, tested among five laboratories. It takes more time, but it allows to completely separate butyric acid from the solvent, trans-18:1 from cis-18:1, 20:1 isomers from 18:3 n-3, 22:1 n-9 from 20:4 n-6, 20:5 n-3 from 24:0 and the main CLA isomers, thus permitting FA quantification in fats and oils for different purposes such as nutritional labeling, quality control and research.Métodos por cromatografía gas-líquido, AOAC 966.06 (2005, AOCS Ce 1h-05 (2005, Ce 1j-07 (2007 permiten determinar ácidos grasos (AG en matrices grasas usando columnas capilares altamente polares y distintos programas de temperatura. No obstante, aún existen dificultades para separar ácido butírico del solvente, pares críticos de AG con polaridades similares, isómeros del ácido linoleico conjugado (CLA, AG de cadena larga poliinsaturados (LC-PUFAs. El objetivo fue mejorar el Método AOCS Ce 1j-07 aplicándolo a la composición en AG de mezcla de aceite soja/girasol, aceite de pescado, mantequilla, usando un programa de temperatura modificado, entre cinco laboratorios. El programa de temperatura elegido, si bien emplea más tiempo, permite separar completamente ácido butírico del solvente, trans-18:1 de cis-18:1, isómeros 20:1 de 18:3 n-3, 22:1 n-9 de 20:4 n-6


    Directory of Open Access Journals (Sweden)

    Ratheesh T


    Full Text Available BACKGROUND: Tinea versicolor is a chronic, mild, usually asymptomatic infection of the stratum corneum. The lesions are discrete or confluent and appear as discolored or hypo pigmented areas of the skin. The affected areas are located principally on the chest, abdomen, upper extremities and back. The etiologic agent is the lipophilic yeast Pityrosporum orbiculare, part of the normal flora of the human skin. This study is undertaken to know “clinical, patterns of the disease with respect to morphology and distribution, associated conditions and epidemiological factors like age, sex distribution and seasonal variation of the disease”. METHODS: Two hundred patients of tinea versicolor were selected. Patients belonging to the age group of above 10 years and below 60 years belonging to both sexes were selected and included in the study group after taking consent. A detailed history was taken with particular reference to onset, duration, symptoms and treatment taken and were recorded. Factors like – seasonal variation, family history and presence of any associated illnesses was also noted. A thorough clinical examination was done with reference to the location, the color, the extent of the lesions, the margins, the type of lesions and the details were recorded. Potassium hydroxide (KOH examination and Wood’s lamp examination were done in all the patients before therapy. RESULTS: Out of 200 patients, majority of them belong to 2nd and 3rd decade of life (72%. The Male: Female ratio was 1.5:1. There was a family history of 16%. The trunk was the most common site involved. Majority of the patients had exacerbation in summer. The most common associated dermatoses were acne vulgaris, immunosuppression and infections. INTERPRETATION AND CONCLUSION: Tinea versicolor is a disease of worldwide distribution, although it is significantly more common in humid and tropical climates. The true incidence cannot be estimated precisely because the disease is

  10. Applying community-based participatory research principles to the development of a smoking-cessation program for American Indian teens: "telling our story". (United States)

    Horn, Kimberly; McCracken, Lyn; Dino, Geri; Brayboy, Missy


    Community-based participatory research provides communities and researchers with opportunities to develop interventions that are effective as well as acceptable and culturally competent. The present project responds to the voices of the North Carolina American Indian (AI) community and the desire for their youth to recognize tobacco addiction and commercial cigarette smoking as debilitating to their health and future. Seven community-based participatory principles led to the AI adaptation of the Not On Tobacco teen-smoking-cessation program and fostered sound research and meaningful results among an historically exploited population. Success was attributed to values-driven, community-based principles that (a) assured recognition of a community-driven need, (b) built on strengths of the tribes, (c) nurtured partnerships in all project phases, (d) integrated the community's cultural knowledge, (e) produced mutually beneficial tools/products, (f) built capacity through co-learning and empowerment, (g) used an iterative process of development, and (h) shared findings/ knowledge with all partners.

  11. Innovative Talents Cultivating Model for Applied Civil Engineering Programs%应用型土木工程专业创新人才培养模式探析

    Institute of Scientific and Technical Information of China (English)

    孙路; 何延宏; 王宇; 李玉胜


    文章通过对应用型本科院校土木工程专业存在的问题进行分析,提出适合学校发展定位的校企共建办学模式,符合国际标准的创新人才培养模式,“双师型”教师队伍建设和课程与教学资源建设等一系列创新人才培养体系的构建方法,并在实践中运行、检验,在教学研究、实践能力、社会资源、学生就业和学科竞赛取得了一些实际成效,以期为同类院校提供借鉴和帮助。%The problems in the programs of civil engineering are analyzed ,based on which some suggestions are proposed .There should be a school-company collaborative training pro-gram,which complies with the international standard of talents training .The “trans-disciplina-ry” teaching team and teaching resource are also necessary .so far,the achievements in practice ( examination ,teaching research ,competence of practice ,social resource ,employment and disci-pline competition ) may of great help for schools of the same type to borrow .

  12. JPRS Report, Epidemiology. (United States)


    Campaign against infantile paralysis, programmed to immunize 6.3 million children from 0 to 5 years of age in the nine states in the region. According...states have been losing ground. The major foci of infantile paralysis are in the northeast, which has not succeeded in meeting the planned goals for...of British Columbia city now has moved into its second phase. Epidemiologist Michele Descamps of the Cancer Control Agency of British Columbia

  13. NASA Remote Sensing Data for Epidemiological Studies (United States)

    Maynard, Nancy G.; Vicente, G. A.


    In response to the need for improved observations of environmental factors to better understand the links between human health and the environment, NASA has established a new program to significantly improve the utilization of NASA's diverse array of data, information, and observations of the Earth for health applications. This initiative, lead by Goddard Space Flight Center (GSFC) has the following goals: (1) To encourage interdisciplinary research on the relationships between environmental parameters (e.g., rainfall, vegetation) and health, (2) Develop practical early warning systems, (3) Create a unique system for the exchange of Earth science and health data, (4) Provide an investigator field support system for customers and partners, (5) Facilitate a system for observation, identification, and surveillance of parameters relevant to environment and health issues. The NASA Environment and Health Program is conducting several interdisciplinary projects to examine applications of remote sensing data and information to a variety of health issues, including studies on malaria, Rift Valley Fever, St. Louis Encephalitis, Dengue Fever, Ebola, African Dust and health, meningitis, asthma, and filariasis. In addition, the NASA program is creating a user-friendly data system to help provide the public health community with easy and timely access to space-based environmental data for epidemiological studies. This NASA data system is being designed to bring land, atmosphere, water and ocean satellite data/products to users not familiar with satellite data/products, but who are knowledgeable in the Geographic Information Systems (GIS) environment. This paper discusses the most recent results of the interdisciplinary environment-health research projects and provides an analysis of the usefulness of the satellite data to epidemiological studies. In addition, there will be a summary of presently-available NASA Earth science data and a description of how it may be obtained.

  14. A Program Against Bacterial Bioterrorism

    DEFF Research Database (Denmark)

    Kemp, Michael; Dargis, Rimtas; Andresen, Keld


    fever, tularemia, trench fever, brucellosis, and melioidosis. The implementation of an antibioterrorism program in a clinical diagnostic setting improved the diagnostic possibilities for patients in Denmark and provided new epidemiologic information. It also introduced a number of diagnostic assays...

  15. Nature cure treatment in the context of India’s epidemiological transition

    Institute of Scientific and Technical Information of China (English)

    Joseph Stewart Alter; Chandrashekar Sharma


    Scholars have argued that theoretical insights of critical medical anthropology should be applied to the analysis of complementary and alternative medicine in order to develop more criticaly engaged integrative medicine. In this essay we focus on nature cure in the context of India’s contemporary epidemiological transition as an example of why engaged integrative medicine is important for public health, and how the institutionalization of nature cure treatment in India provides a critical framework for the development of programs focused on holistic treatment and prevention. After providing an overview of the epidemiological transition in contemporary India, we develop this argument through an examination of ilustrative cases in a clinic that operates within the structure of India’s Central Council for Research on Yoga and Naturopathy. Based on a review of recent history and contemporary practice we describe how a system of medicine that makes use exclusively of air, earth, sunlight, water and food has been institutionalized and professionalized in India. Whereas biomedical treatment for chronic non-communicable diseases is focused on the problem of curing individual diseases, nature cure establishes a regimen of personalized public healthcare for the integrated management of symptoms. We argue that nature cure is based on an ecological understanding of health, thus providing treatment that refl ects a broad appreciation for the risk factors that characterize India’s current crises of public health.

  16. 1995 annual epidemiologic surveillance report for Sandia National Laboratory-Albuquerque

    Energy Technology Data Exchange (ETDEWEB)



    The US Department of Energy`s (DOE`s) conduct of epidemiologic surveillance provides an early warning system for health problems among workers. This program monitors illnesses and injuries that result in an absence of five or more consecutive workdays, occupational injuries and illnesses, and disabilities and deaths among current workers. This report provides a summary of epidemiologic surveillance data collected from the Sandia National Laboratory-Albuquerque (SNL-AL) from January 1, 1995 through December 31, 1995. The data were collected by a coordinator at SNL-AL and submitted to the Epidemiologic Surveillance Data Center, located at Oak Ridge Institute for Science and Education, where quality control procedures and data analyses were carried out. The annual report for 1995 has been redesigned from reports for previous years. Most of the information in the previous reports is also in this report, but some material now appears in the appendices instead of the main body of the report. The information presented in the main body of the report provides a descriptive analysis of the data collected from the site and the appendices provide more detail. A new section of the report presents trends in health over time. The Glossary and an Explanation of Diagnostic Categories have been expanded with more examples of diagnoses to illustrate the content of each category. The data presented here apply only to SNL-AL. The DOE sites are varied, so comparisons of SNL-AL with other DOE sites should be made with caution. It is important to keep in mind that many factors can affect the completeness and accuracy of health information collected at the sites as well as affect patterns of illness and injury observed.

  17. 1995 annual epidemiologic surveillance report for Hanford Site

    Energy Technology Data Exchange (ETDEWEB)



    The US Department of Energy`s (DOE) commitment to assuring the health and safety of its workers includes the conduct of epidemiologic surveillance activities that provide an early warning system for health problems among workers. A number of DOE sites participate in the Epidemiologic Surveillance Program. This program monitors illnesses and health conditions that result in an absence of five or more consecutive workdays, occupational injuries and illnesses, disabilities and deaths among current workers. This report provides a summary of epidemiologic surveillance data collected from the Hanford Site from January 1, 1995 through December 31, 1995. The data were collected by a coordinator at Hanford and submitted to the Epidemiologic Surveillance Data Center, located at Oak Ridge Institute for Science and Education, where quality control procedures and data analyses were carried out. The information in the main body of the report provides a descriptive analysis of the data collected from the site, and the appendices provides additional detail. The report also contains an expanded Glossary and an Explanation of Diagnostic Categories which gives examples of health conditions in each of the diagnostic categories.

  18. Epidemiología y control de la cisticercosis en el Perú Epidemiology and control of cysticercosis in Peru

    Directory of Open Access Journals (Sweden)

    Hector H. Garcia


    Full Text Available La neurocisticercosis, infección del sistema nervioso humano por el estadio larvario de la Taenia solium, es una causa importante de epilepsia y otras manifestaciones neurológicas en el Perú y en la mayoría de países en desarrollo. Desde 1987, el Grupo de Trabajo en Cisticercosis en Perú ha desarrollado una serie de estudios epidemiológicos que han llevado a estimar el impacto y entender la transmisión de la Taenia solium, y que posteriormente se aplicaron al diseño y ejecución de un programa de control en Tumbes, en la costa norte del país. En este artículo se revisan los principales hallazgos epidemiológicos, así como las líneas generales del programa de eliminación y las herramientas utilizadas. Los avances en el control de la teniasis/cisticercosis en nuestro país abren el camino hacia su eliminación y eventual erradicación.Neurocysticercosis, the infection of the human central nervous system by the larval stage of the cestode Taenia solium, is an important cause of epilepsy and other neurological manifestations in Peru and most developing countries. Since 1987, the Cysticercosis Working Group in Peru has performed a series of epidemiological studies which led to estimate the impact and to better understand the transmission of Taenia solium. This information was later applied to the design and execution of a control program in Tumbes, in the Northern Coast of Peru. This paper reviews the main epidemiological findings, as well as the conceptual framework of the elimination program and the tools used. Advances in the control of taeniasis/cysticercosis in our country open the road towards its elimination and potential eradication.

  19. Epidemiology of idiopathic pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    Ley B


    Full Text Available Brett Ley, Harold R Collard Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California, USA Abstract: Idiopathic pulmonary fibrosis is a chronic fibrotic lung disease of unknown cause that occurs in adults and has a poor prognosis. Its epidemiology has been difficult to study because of its rarity and evolution in diagnostic and coding practices. Though uncommon, it is likely underappreciated both in terms of its occurrence (ie, incidence, prevalence and public health impact (ie, health care costs and resource utilization. Incidence and mortality appear to be on the rise, and prevalence is expected to increase with the aging population. Potential risk factors include occupational and environmental exposures, tobacco smoking, gastroesophageal reflux, and genetic factors. An accurate understanding of its epidemiology is important, especially as novel therapies are emerging. Keywords: idiopathic pulmonary fibrosis, epidemiology, incidence, prevalence, mortality, risk factors

  20. Viral marketing as epidemiological model

    CERN Document Server

    Rodrigues, Helena Sofia


    In epidemiology, an epidemic is defined as the spread of an infectious disease to a large number of people in a given population within a short period of time. In the marketing context, a message is viral when it is broadly sent and received by the target market through person-to-person transmission. This specific marketing communication strategy is commonly referred as viral marketing. Due to this similarity between an epidemic and the viral marketing process and because the understanding of the critical factors to this communications strategy effectiveness remain largely unknown, the mathematical models in epidemiology are presented in this marketing specific field. In this paper, an epidemiological model SIR (Susceptible- Infected-Recovered) to study the effects of a viral marketing strategy is presented. It is made a comparison between the disease parameters and the marketing application, and simulations using the Matlab software are performed. Finally, some conclusions are given and their marketing impli...

  1. Epidemiología de campo y epidemiología social Field epidemiology and social epidemiology

    Directory of Open Access Journals (Sweden)

    Javier Segura del Pozo


    Full Text Available Mediante la comparación de la epidemiología de campo y la epidemiología social, se pretende reflexionar sobre los imaginarios no explícitos que operan en ambos ámbitos, necesariamente convergentes, sobre los obstáculos de la práctica epidemiológica actual para alcanzar su función social y sobre la necesidad de cambiar las bases epistemológicas, metodológicas y prácticas que operan en la epidemiología, empezando por la formación del epidemiólogo de campo. La epidemiología de campo tiende a la acción sin marco teórico. La epidemiología social, por el contrario, tiende a los desarrollos teóricos (reflexión e investigación sobre los determinantes sociales alejados de la acción, debido a los limitantes para cambiar las políticas públicas. Otras diferencias se sitúan en el nivel de intervención (micro/macroespacios, el objeto de intervención (control del brote frente a control de las desigualdades y en la forma de articular la comunicación con la sociedad. Se asemejan en la preocupación por el método, la predominancia de una orientación positivista y condicionada por la estadística, aunque en proceso de cierta apertura epistemológica, la tensión experimentada entre relacionarse con un mundo virtual de bases de datos o con la sociedad real, su situación en la periferia del sistema político-social-institucional-profesional y por estar abocadas a la frustración profesional. Finalmente, se formulan 10 interrogantes a los epidemiólogos de campo sobre su práctica actual, a través de los cuales se podría evaluar si están realizando una epidemiología social, y se sugieren cambios para introducir en la formación y práctica del epidemiólogo.Comparing field epidemiology and social epidemiology, we pretend to think about the no explicit images and meanings operating in both necessary convergent fields, about the obstacles present in epidemiological practice to fulfil its social function and about the necessity of

  2. [Epidemiology of tuberculosis in France in 2008]. (United States)

    Che, D; Antoine, D


    A total of 5,758 tuberculosis cases were notified in France in 2008, giving a rate of nine cases per 100,000 inhabitants. The median age was 45 years and 59% of cases were male patients. Île-de-France (Paris and greater Paris area) and French Guiana had the highest notification rate in 2008 (17.9/10(5) and 22.6/10(5) respectively). The rate of tuberculosis was higher in individuals born abroad (43.2/10(5) vs. 5.0/10(5) for individuals born in France), especially those recently arrived in France. Pulmonary tuberculosis accounted for 72% of notified cases, 76% of which were potentially contagious (positive sputum smear, or culture). Compared to 2007, the number of notified tuberculosis cases increased by 3.3% in 2008. This increase was not accompanied by a rise of severe cases (meningitis and miliary TB); this seemed to be due partly to improvement in identification and notification of cases. However this trend could require specific monitoring in future years. A national tuberculosis control program was launched in France in 2007, aiming at reducing epidemiological disparities. Clinical and public health expertise needs to be maintained on all the territory to ensure that implemented measures can have the expected impact on the epidemiology of the disease.

  3. Epidemiological review of gastric cancer in India

    Directory of Open Access Journals (Sweden)

    Rajesh P Dikshit


    Full Text Available Stomach cancer is the one of the leading cause of cancer in southern region of India. Its incidence is decreasing worldwide yet on global scale stomach cancer remains one of the most common causes of cancer death. Etiology of gastric cancer includes Helicobacter pylori infection, diet and lifestyle, tobacco, alcohol and genetic susceptibility. In this review, we tried to find the contribution of Indian scientist in understanding the descriptive and observational epidemiology of stomach cancer. PubMed was used as a search platform using key words such as "stomach cancer, treatment, clinical characteristics, stomach cancer outcome, epidemiology, etiological factor and their corresponding Mesh terms were used in combination with Boolean operators OR, AND". Most of the reported studies on gastric cancer from India are case report or case series and few are case-control studies. Indian studies on this topic are limited and have observed H. pylori infection, salted tea, pickled food, rice intake, spicy food, soda (additive of food, tobacco and alcohol as risk factors for gastric cancer. More research is required to understand the etiology, develop suitable screening test, to demarcate high-risk population and to develop and evaluate the effect of primary prevention programs.

  4. Applied survival analysis using R

    CERN Document Server

    Moore, Dirk F


    Applied Survival Analysis Using R covers the main principles of survival analysis, gives examples of how it is applied, and teaches how to put those principles to use to analyze data using R as a vehicle. Survival data, where the primary outcome is time to a specific event, arise in many areas of biomedical research, including clinical trials, epidemiological studies, and studies of animals. Many survival methods are extensions of techniques used in linear regression and categorical data, while other aspects of this field are unique to survival data. This text employs numerous actual examples to illustrate survival curve estimation, comparison of survivals of different groups, proper accounting for censoring and truncation, model variable selection, and residual analysis. Because explaining survival analysis requires more advanced mathematics than many other statistical topics, this book is organized with basic concepts and most frequently used procedures covered in earlier chapters, with more advanced topics...

  5. Developing a foundation for eco-epidemiological assessment of aquatic ecological status over large geographic regions utilizing existing data resources and models. (United States)

    Kapo, Katherine E; Holmes, Christopher M; Dyer, Scott D; de Zwart, Dick; Posthuma, Leo


    Eco-epidemiological studies utilizing existing monitoring program data provide a cost-effective means to bridge the gap between the ecological status and chemical status of watersheds and to develop hypotheses of stressor attribution that can influence the design of higher-tier assessments and subsequent management. The present study describes the process of combining existing data and models to develop a robust starting point for eco-epidemiological analyses of watersheds over large geographic scales. Data resources from multiple federal and local agencies representing a range of biological, chemical, physical, toxicological, and other landscape factors across the state of Ohio, USA (2000-2007), were integrated with the National Hydrography Dataset Plus hydrologic model (US Environmental Protection Agency and US Geological Survey). A variety of variable reduction, selection, and optimization strategies were applied to develop eco-epidemiological data sets for fish and macroinvertebrate communities. The relative importance of landscape variables was compared across spatial scales (local catchment, watershed, near-stream) using conditional inference forests to determine the scales most relevant to variation in biological community condition. Conditional inference forest analysis applied to a holistic set of environmental variables yielded stressor-response hypotheses at the statewide and eco-regional levels. The analysis confirmed the dominant influence of state-level stressors such as physical habitat condition, while highlighting differences in predictive strength of other stressors based on ecoregional and land-use characteristics. This exercise lays the groundwork for subsequent work designed to move closer to causal inference.

  6. Nephrogenic systemic fibrosis: epidemiology update

    DEFF Research Database (Denmark)

    Marckmann, P.


    Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated that gadoli......Purpose of review The aim of this article is to outline the history of nephrogenic systemic fibrosis, a new and serious disease of patients with renal failure, and to give an update on its aetiology and prevalence. Recent findings Epidemiological and histochemical studies demonstrated...

  7. Network epidemiology and plant trade networks. (United States)

    Pautasso, Marco; Jeger, Mike J


    Models of epidemics in complex networks are improving our predictive understanding of infectious disease outbreaks. Nonetheless, applying network theory to plant pathology is still a challenge. This overview summarizes some key developments in network epidemiology that are likely to facilitate its application in the study and management of plant diseases. Recent surveys have provided much-needed datasets on contact patterns and human mobility in social networks, but plant trade networks are still understudied. Human (and plant) mobility levels across the planet are unprecedented-there is thus much potential in the use of network theory by plant health authorities and researchers. Given the directed and hierarchical nature of plant trade networks, there is a need for plant epidemiologists to further develop models based on undirected and homogeneous networks. More realistic plant health scenarios would also be obtained by developing epidemic models in dynamic, rather than static, networks. For plant diseases spread by the horticultural and ornamental trade, there is the challenge of developing spatio-temporal epidemic simulations integrating network data. The use of network theory in plant epidemiology is a promising avenue and could contribute to anticipating and preventing plant health emergencies such as European ash dieback.

  8. 外国语言学及应用语言学硕士学科点课程规划研究%The Curriculum Layout for the Master's Degree Program of Foreign Linguistics an,d Applied Linguistics

    Institute of Scientific and Technical Information of China (English)



    Ingenuous layout and improvement are required for the Master' s Degree Program of Foreign Linguistics and Applied Linguistics, in which the scientificalness, systematicness and gradual profundity are undoubtedly a crucial link in advancing post-graduates' quality and overall development. The paper researches into the renovation of teaching ideology, the implication of the fields targeted, the integrity of the curriculua, and the efficiency of the measures guaranteed, in view of the overall layout of the fields of the Master' s Degree Program of Foreign Linguistics and Applied Linguistics.%外国语言学及应用语言学硕士学科点需要规划和建设,而课程体系的科学性、层级性和系统性无疑是牵动硕士生质量提升和素质优化的关键一环.结合外国语言学及应用语言学硕士学科点的方向设置,对教学理念的更新,专业方向蕴涵的把握,课程体系的完整配套,保障措施的得力有效等问题进行了探讨.

  9. Immunology and Epidemiology

    CERN Document Server

    Hraba, Tomáš


    In February 1985 a small international meeting of scientists took place at the recreation resort of the Polish Academy of Sci­ ences in Mogilany, near Cracow, Poland. The initiative for holding the workshop came from a working meeting on mathematical immunology and related topics at the International Institute for Applied Sys­ tems Analysis in Laxenburg, Austria, in November 1983. In addition to representatives of IIASA, delegates of the IIASA National Member Organizations (NMO) of Czechoslovakia, Italy, and the soviet Union took part in that working meeting. The participants came to the conclusion that IIASA could play an important role in facilitating the development of research in this field. The first step that they recommended to I IASA was to organize a workshop on mathematical immunology. The purpose of the workshop was to review the progress that has been made in applying mathematics to problems in immunology and to explore ways in which further progress might be achieved, especially by more efficie...

  10. Childhood tuberculosis: epidemiology, diagnosis, treatment, and vaccination. (United States)

    Tsai, Kuo-Sheng; Chang, Hsiao-Ling; Chien, Shun-Tien; Chen, Kwo-Liang; Chen, Kou-Huang; Mai, Ming-Hsin; Chen, Kow-Tong


    Despite the existence of a government-run tuberculosis (TB) control program, the current nationwide burden of TB continues to be a public health problem in Taiwan. Intense current and previous efforts into diagnostic, therapeutic, and preventive interventions have focused on TB in adults, but childhood TB has been relatively neglected. Children are particularly vulnerable to severe disease and death following infection, and children with latent infections become reservoirs for future transmission following disease reactivation in adulthood, thus fueling future epidemics. Additional research, understanding, and prevention of childhood TB are urgently needed. This review assesses the epidemiology, diagnosis, treatment, and relevant principles of TB vaccine development and presents efficacy data for the currently licensed vaccines.

  11. Assessing performance of feedlot operations using epidemiology. (United States)

    Corbin, Marilyn J; Griffin, Dee


    The progressive feedlot veterinarian must be well versed not only in individual production animal medicine, but also in population-based medicine. Feedlot health programs must be goal oriented, and evaluation of these goals is accomplished through diligent use of record systems and analytic evaluation of these record systems. Basic feedlot monitoring parameters include health and economic parameters in addition to the use of bench marking parameters between and among feed yards. When these parameters have significant changes, steps should be initiated to begin field investigations. Feedlot epidemiology uses several novel applications such as partial budgeting, risk assessment, and packing plant audits to provide scientifically sound and economically feasible solutions for the feeding industry.

  12. [Epidemiology of mood disorders]. (United States)

    Rouillon, Frédéric


    The 12 months and lifetime prevalence of is respectively 5 and 9% in the general population; moreover 10 to 20% of general practice patients are depressed. Depression is involved in about 40 to 80% of suicide and induces one of the greatest social burden. Mood disorders are more frequent in women, individual living alone and people with low socio-economic level. Risk factors are stressfull life events, biological vulnerability (genetic factors), somatic diseases, psychiatric comorbidity including personality disorders and addictions. Depressive disorders are underdiagnosed and undertreated despite efficacious pharmacological and psychotherapeutic strategies in their treatment. It's the reason why public health programs to prevent depression have been promoted by many countries like European Alliance against Depression. Their efficacy must be evaluated as their cost-efficiency.

  13. Why does epidemiology need better questionnaires?

    DEFF Research Database (Denmark)

    Tong, S.; Ring, I.; Olsen, Jørn


    The authors argue for the use of validated questionnaires whenever possible to improve the quality of epidemiological research.......The authors argue for the use of validated questionnaires whenever possible to improve the quality of epidemiological research....

  14. Mitochondrial DNA and Cancer Epidemiology Workshop (United States)

    A workshop to review the state-of-the science in the mitochondrial DNA field and its use in cancer epidemiology, and to develop a concept for a research initiative on mitochondrial DNA and cancer epidemiology.

  15. Molecular epidemiology of glanders, Pakistan. (United States)

    Hornstra, Heidie; Pearson, Talima; Georgia, Shalamar; Liguori, Andrew; Dale, Julia; Price, Erin; O'Neill, Matthew; Deshazer, David; Muhammad, Ghulam; Saqib, Muhammad; Naureen, Abeera; Keim, Paul


    We collected epidemiologic and molecular data from Burkholderia mallei isolates from equines in Punjab, Pakistan from 1999 through 2007. We show that recent outbreaks are genetically distinct from available whole genome sequences and that these genotypes are persistent and ubiquitous in Punjab, probably due to human-mediated movement of equines.

  16. Molecular Epidemiology of Glanders, Pakistan


    Hornstra, Heidie; Pearson, Talima; Georgia, Shalamar; Liguori, Andrew; Dale, Julia; Price, Erin; O’Neill, Matthew; DeShazer, David; Muhammad, Ghulam; Saqib, Muhammad; Naureen, Abeera; Keim, Paul


    We collected epidemiologic and molecular data from Burkholderia mallei isolates from equines in Punjab, Pakistan from 1999 through 2007. We show that recent outbreaks are genetically distinct from available whole genome sequences and that these genotypes are persistent and ubiquitous in Punjab, probably due to human-mediated movement of equines.

  17. Candida infections : detection and epidemiology

    NARCIS (Netherlands)

    Borst, A. (Annemarie)


    Despite the fact that the yeast Candida is the number 4 cause of bloodstream infections in the United States and ranks number 8 in Europe, adequate detection methods are lacking. Furthermore, relatively little is known about the epidemiology of Candida. Our aim was to improve the detection and ident

  18. Glossary for econometrics and epidemiology. (United States)

    Gunasekara, F Imlach; Carter, K; Blakely, T


    Epidemiologists and econometricians are often interested in similar topics-socioeconomic position and health outcomes-but the different languages that epidemiologists and economists use to interpret and discuss their results can create a barrier to mutual communication. This glossary defines key terms used in econometrics and epidemiology to assist in bridging this gap.

  19. Brain Tumor Epidemiology Consortium (BTEC) (United States)

    The Brain Tumor Epidemiology Consortium is an open scientific forum organized to foster the development of multi-center, international and inter-disciplinary collaborations that will lead to a better understanding of the etiology, outcomes, and prevention of brain tumors.

  20. The evolving epidemiology of inflammatory bowel disease.

    LENUS (Irish Health Repository)

    Shanahan, Fergus


    Epidemiologic studies in inflammatory bowel disease (IBD) include assessments of disease burden and evolving patterns of disease presentation. Although it is hoped that sound epidemiologic studies provide aetiological clues, traditional risk factor-based epidemiology has provided limited insights into either Crohn\\'s disease or ulcerative colitis etiopathogenesis. In this update, we will summarize how the changing epidemiology of IBD associated with modernization can be reconciled with current concepts of disease mechanisms and will discuss studies of clinically significant comorbidity in IBD.

  1. The Global Epidemiologic Transition: Noncommunicable Diseases and Emerging Health Risk of Allergic Disease in Sub-Saharan Africa (United States)

    Atiim, George A.; Elliott, Susan J.


    Globally, there has been a shift in the causes of illness and death from infectious diseases to noncommunicable diseases. This changing pattern has been attributed to the effects of an (ongoing) epidemiologic transition. Although researchers have applied epidemiologic transition theory to questions of global health, there have been relatively few…

  2. Travel epidemiology: the Saudi perspective. (United States)

    Memish, Ziad A; Venkatesh, S; Ahmed, Qanta A


    The Kingdom of Saudi Arabia occupies four-fifths of the Arabian Peninsula, with a land area of 2 million square kilometres. Saudi Arabia holds a unique position in the Islamic world, as the custodian of the two holiest places of Islam, in Mecca and Medina. Annually, some 2 million Muslims from over 140 countries embark on Hajj. This extraordinary en masse migration is a unique forum for the study of travel epidemiology since the Hajj carries various health risks, both communicable and non-communicable, often on a colossal scale. Non-communicable hazards of the Hajj include stampede and motor vehicle trauma, fire-related burn injuries and accidental hand injury during animal slaughter. Communicable hazards in the form of outbreaks of multiple infectious diseases have been reported repeatedly, during and following the Hajj. Meningococcal meningitis, gastroenteritis, hepatitis A, B and C, and various zoonotic diseases comprise some of the possible infectious hazards at the Hajj. Many of these infectious and non-infectious hazards can be avoided or averted by adopting appropriate prophylactic measures. Physicians and health personnel must be aware of these risks to appropriately educate, immunize and prepare these travellers facing the unique epidemiological challenges of Hajj in an effort to minimize untoward effects. Travel epidemiology related to the Hajj is a new and exciting area, which offers valuable insights to the travel specialist. The sheer scale of numbers affords a rare view of migration medicine in action. As data is continually gathered and both national and international policy making is tailored to vital insights gained through travel epidemiology, the Hajj will be continually safeguarded. Practitioners will gain from findings of travel related epidemiological changes in evolution at the Hajj: the impact of vaccinating policies, infection control policies and public health are afforded a real-world laboratory setting at each annual Hajj, allowing us to

  3. History and philosophy of modern epidemiology

    DEFF Research Database (Denmark)

    Andersen, Hanne


    Epidemiological studies of chronic diseases began around the mid-20th century. Contrary to the infectious disease epidemiology which had prevailed at the beginning of the 20th century and which had focused on single agents causing individual diseases, the chronic disease epidemiology which emerge...

  4. 1995 annual epidemiologic surveillance report for Idaho National Engineering and Environmental Laboratory

    Energy Technology Data Exchange (ETDEWEB)



    The US Department of Energy's (DOE) conduct of epidemiologic surveillance provides an early warning system for health problems among workers. This program monitors illnesses and health conditions that result in an absence of five or more consecutive workdays, occupational injuries and illnesses, and disabilities and deaths among current workers. This report summarizes epidemiologic surveillance data collected from the Idaho National Engineering and Environmental Laboratory (INEEL) from January 1, 1995 through December 31, 1995. The data were collected by a coordinator at INEEL and submitted to the Epidemiologic Surveillance Data Center, located at Oak Ridge Institute for Science and Education, where quality control procedures and data analyses were carried out.

  5. Molecular Epidemiology of Brucella abortus in Northern Ireland-1991 to 2012.

    Directory of Open Access Journals (Sweden)

    Adrian Allen

    Full Text Available Brucellosis is the most common bacterial zoonoses worldwide. Bovine brucellosis caused by Brucella abortus has far reaching animal health and economic impacts at both the local and national levels. Alongside traditional veterinary epidemiology, the use of molecular typing has recently been applied to inform on bacterial population structure and identify epidemiologically-linked cases of infection. Multi-locus variable number tandem repeat VNTR analysis (MLVA was used to investigate the molecular epidemiology of a well-characterised Brucella abortus epidemic in Northern Ireland involving 387 herds between 1991 and 2012.MLVA identified 98 unique B. abortus genotypes from disclosing isolates in the 387 herds involved in the epidemic. Clustering algorithms revealed the relatedness of many of these genotypes. Combined with epidemiological information on chronology of infection and geographic location, these genotype data helped to identify 7 clonal complexes which underpinned the outbreak over the defined period. Hyper-variability of some VNTR loci both within herds and individual animals led to detection of multiple genotypes associated with single outbreaks. However with dense sampling, these genotypes could still be associated with specific clonal complexes thereby permitting inference of epidemiological links. MLVA- based epidemiological monitoring data were congruent with an independent classical veterinary epidemiology study carried out in the same territory.MLVA is a useful tool in ongoing disease surveillance of B. abortus outbreaks, especially when combined with accurate epidemiological information on disease tracings, geographical clustering of cases and chronology of infection.

  6. [Understanding and intervention: a dimension of collaboration of anthropology and epidemiology]. (United States)

    Song, Lei-Ming; Wang, Ning


    'Epidemiological intervention' involves many social and cultural contents and can be recognized as a social cultural practice. If we know more about the relevant social cultural background of the objects on intervention measures and intervention, the goals would more successful and effective be reached. Since anthropology is specialized in understanding relevant social and cultural contents, the understanding of anthropology should be viewed both as important prerequisite and foundation of the epidemiological intervention programs.

  7. Childhood brain tumor epidemiology: a brain tumor epidemiology consortium review. (United States)

    Johnson, Kimberly J; Cullen, Jennifer; Barnholtz-Sloan, Jill S; Ostrom, Quinn T; Langer, Chelsea E; Turner, Michelle C; McKean-Cowdin, Roberta; Fisher, James L; Lupo, Philip J; Partap, Sonia; Schwartzbaum, Judith A; Scheurer, Michael E


    Childhood brain tumors are the most common pediatric solid tumor and include several histologic subtypes. Although progress has been made in improving survival rates for some subtypes, understanding of risk factors for childhood brain tumors remains limited to a few genetic syndromes and ionizing radiation to the head and neck. In this report, we review descriptive and analytical epidemiology childhood brain tumor studies from the past decade and highlight priority areas for future epidemiology investigations and methodological work that is needed to advance our understanding of childhood brain tumor causes. Specifically, we summarize the results of a review of studies published since 2004 that have analyzed incidence and survival in different international regions and that have examined potential genetic, immune system, developmental and birth characteristics, and environmental risk factors. Cancer Epidemiol Biomarkers Prev; 23(12); 2716-36. ©2014 AACR.

  8. Comprehensive Program Review: Applying TQM Principles. (United States)

    Ostroth, D. David


    Reviews one system successfully used to implement Total Quality Management (TQM) principles and techniques in a student affairs department at a large public university. Discusses TQM applications and argues that implementation of TQM requires both planned staff training and an organization-wide culture change. (RJM)

  9. Epidemiologic trends of leprosy for the 21st century. (United States)

    Schreuder, Pieter A M; Noto, Salvatore; Richardus, Jan Hendrik


    Major gaps still exist in the knowledge about leprosy, particularly with regard to how it spreads. Leprosy epidemiology remains complicated due to the specific characteristics of Mycobacterium leprae. To describe epidemiologic trends for the 21st century, the first part of this paper gives an overview of the epidemiology of leprosy, followed by past trends and the present situation of new-case detection as a proxy of the incidence. The third part, regarding predicted epidemiologic trends for the 21st century, elaborates on the main topic of this paper. With limited diagnostic tools to detect infection with M leprae, other methods are necessary to estimate trends in incidence and transmission. A computer program has been developed for modeling the transmission and control of leprosy (SIMLEP). The effect of failure to sustain early case detection beyond 2005 on leprosy incidence and case detection is shown. Important unanswered questions are whether the incubation period is contagious and how rapid close contacts of leprosy patients are infected. As long as such key questions remain unanswered, it will be difficult to estimate the impact of control strategies on the transmission of M leprae on resulting disease incidence. In the meantime we can expect that the global new-case detection trends will stay more or less stable or only decrease slightly for many years to come. There is a need of new preventive interventions to change this situation and reduce the incidence of leprosy in the 21st century.

  10. Analysis of epidemiological characteristics for hepatitis A after introduction of hepatitis A vaccine into immunization program in Xuchang City%许昌市甲型病毒性肝炎疫苗纳入免疫规划后的甲肝流行特征分析

    Institute of Scientific and Technical Information of China (English)



    Objective To analyze the epidemiological characterriics of hepatitis A after introduction of hepatitis A vaccine into immunization program, and to provide a scientific evidence for the prevention and control measures in related disease. Methods The descriptive epidemiology was carried out in analysis of hepatitis A outbreak from 2005 to 2014 in Xuchang City.The epidemic characteristics were analyzed by SPSS before and after hepatitis A vaccine was introduced into the na-tional immunization program.Results The epidemic intensity and the incidence rate were decreased after introduction of the hepatitis A vaccine into the program. The age of occuring the disese shifted older and there was no variation in seasons. The infected populations were farmer and student.The difference in average incidence rate was not significant in between city and rural area.The incidence in Yanling County is the highest because of the poor economic and healthy conditions, and low immunization rate.Conclusion The vaccination rates and quality were rapidly improved after introduction of hep-atitis A vaccine into national immunization.The epidemiological characteristics of hepatitis A have a significant change. The vaccination of key populations should be strengthened and expanded on the basis of routine immunization of hepatitis A vaccine in the future.It is important to pay attention to the monitoring and risk assessment of the epidemic, health educa-tion in key areas and the public to improve the working and learning environments.The local outbreak of hepatitis A should be under prevention and control.%目的:分析甲肝疫苗纳入国家免疫规划后的甲肝流行特征,为制定有效控制措施提供科学依据。方法采用描述流行病学方法对2005—2014年许昌市甲肝疫情进行描述,利用SPSS软件对甲肝疫苗纳入国家免疫规划前后流行特征进行对比分析。结果甲肝疫苗纳入国家免疫规划后,甲肝流行强度减弱,发病率

  11. Epidemiology of cancer in Malaysia. (United States)

    Lo, E K


    Some information on cancer in Malaysia are available, and its epidemiology is described. There is a need for systematic and coordinated collection of cancer statistics which are essential to patient management, cancer control programme formulation, implementation and evaluation. The decision of the Ministry of Health to introduce National Cancer Registry and to encourage epidemiological studies, which will ultimately lead to the utilization of data and introduction of control and preventive activities for cancers are positive steps in the right direction. Meanwhile, curative and palliative treatment is available from the existing hospital facilities, and preventive activities such as actions on smoking and health will be continued until such time when a comprehensive prevention and control programme for cancers in the country is evolved.

  12. "Epidemiological criminology": coming full circle. (United States)

    Akers, Timothy A; Lanier, Mark M


    Members of the public health and criminal justice disciplines often work with marginalized populations: people at high risk of drug use, health problems, incarceration, and other difficulties. As these fields increasingly overlap, distinctions between them are blurred, as numerous research reports and funding trends document. However, explicit theoretical and methodological linkages between the 2 disciplines remain rare. A new paradigm that links methods and statistical models of public health with those of their criminal justice counterparts is needed, as are increased linkages between epidemiological analogies, theories, and models and the corresponding tools of criminology. We outline disciplinary commonalities and distinctions, present policy examples that integrate similarities, and propose "epidemiological criminology" as a bridging framework.

  13. [Epidemiology of burns in France]. (United States)

    Latarjet, Jacques; Ravat, François


    As with most traumas, the epidemiology of the "burn" health-event has long been neglected by public health doctors and rarely considered by burns specialists. There were therefore few verified data and many approximations and preconceived ideas. The gathering of information recently undertaken in France enables the reliability of the data to be improved and the diagnostic and demographic elements relating to hospitalised patients with burns to be established.

  14. Epidemiological characteristics of gastric cancer


    Šipetić Sandra B.; Tomić-Kundaković Slađana; Vlajinac Hristina D.; Maksimović Nataša; Knežević Anita; Kisić Darija


    Introduction. Gastric cancer was the third most common cancer worldwide in 2000, accounting for approximately 876 000 new cases or 9% of the global cancer burden. Epidemiological characteristics As a result of changes in diet, the incidence of gastric cancer has decreased in most countries. Now days, consumption of fresh vegetables and fruits is increasing in regard to canned food. In addition to unhealthy diet, the main risk factors for gastric cancer are H. pylori infection, alcohol consump...

  15. Biomarkers in Prostate Cancer Epidemiology

    Directory of Open Access Journals (Sweden)

    Mudit Verma


    Full Text Available Understanding the etiology of a disease such as prostate cancer may help in identifying populations at high risk, timely intervention of the disease, and proper treatment. Biomarkers, along with exposure history and clinical data, are useful tools to achieve these goals. Individual risk and population incidence of prostate cancer result from the intervention of genetic susceptibility and exposure. Biochemical, epigenetic, genetic, and imaging biomarkers are used to identify people at high risk for developing prostate cancer. In cancer epidemiology, epigenetic biomarkers offer advantages over other types of biomarkers because they are expressed against a person’s genetic background and environmental exposure, and because abnormal events occur early in cancer development, which includes several epigenetic alterations in cancer cells. This article describes different biomarkers that have potential use in studying the epidemiology of prostate cancer. We also discuss the characteristics of an ideal biomarker for prostate cancer, and technologies utilized for biomarker assays. Among epigenetic biomarkers, most reports indicate GSTP1 hypermethylation as the diagnostic marker for prostate cancer; however, NKX2-5, CLSTN1, SPOCK2, SLC16A12, DPYS, and NSE1 also have been reported to be regulated by methylation mechanisms in prostate cancer. Current challenges in utilization of biomarkers in prostate cancer diagnosis and epidemiologic studies and potential solutions also are discussed.


    Directory of Open Access Journals (Sweden)

    Dennis J. Caine


    Full Text Available The objective of the book is to review comprehensively what is known about the distribution and determinants of injury rates in a variety of individual sports, and to suggest injury prevention measures and guidelines for further research. This book provides comprehensive compilation and critical analysis of epidemiological data over children's individual sports: including equestrian, gymnastics, martial arts, skiing and snowboarding, tennis, track and field, and wrestling. This book encourages coaches and sports administrators to discuss rules, equipment standards, techniques, and athlete conditioning programs. In turn, they can inform parents about the risks and how they can help their children avoid or limit injury in sports. A common, uniform strategy and evidence-based approach to organizing and interpreting the literature is used in all chapters. All the sports-specific chapters are laid out with the same basic headings, so that it is easy for the reader to find common information across chapters. Chapter headings are: 1 Epidemiology of children's individual sports injuries, 2 Equestrian injuries, 2 Gymnastics injuries, 3 Martial arts injuries, 4 Skiing and snowboard injuries, 5 Tennis injuries, 6 Track and field injuries, 7 Wrestling injuries, 8 Injury prevention and future research. Chapter headings include: i Incidence of injury, ii Injury characteristics, iii Injury severity, iv njury risk factors, v Suggestions for injury prevention, vi Suggestions for further research. In each sports-specific chapter, an epidemiological picture has been systematically developed from the data available in prospective cohort, retrospective cohort, case-control, and cross-sectional studies. The tables are numerous, helpful and very useful. The book provides a very useful resource for sport scientist, pediatricians, family practitioners and healthcare professionals in the field of child and adolescent injury and prevention The readers are going to

  17. 42 CFR 431.708 - Procedures for applying standards. (United States)


    ... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE ORGANIZATION AND GENERAL ADMINISTRATION State Programs for Licensing Nursing Home Administrators § 431.708 Procedures for applying standards. The...

  18. Applied statistical inference with MINITAB

    CERN Document Server

    Lesik, Sally


    Through clear, step-by-step mathematical calculations, Applied Statistical Inference with MINITAB enables students to gain a solid understanding of how to apply statistical techniques using a statistical software program. It focuses on the concepts of confidence intervals, hypothesis testing, validating model assumptions, and power analysis.Illustrates the techniques and methods using MINITABAfter introducing some common terminology, the author explains how to create simple graphs using MINITAB and how to calculate descriptive statistics using both traditional hand computations and MINITAB. Sh

  19. Snow's case revisited: New tool in geographic profiling of epidemiology


    Papini, Alessio; Santosuosso, Ugo


    Geographic Profiling technique is used to find the origin of a series of crimes. The method was recently extended to other fields. One of the best renowned data in epidemiology is that by John Snow during an outburst of cholera in London. We wrote Python scripts to perform the analyses to apply the Geographic Profiling for individuating the starting origin of an infection by using the old Snow's data set. We modified the method by applying a weight to each point of the map where cases of chol...

  20. Major depression epidemiology from a diathesis-stress conceptualization

    Directory of Open Access Journals (Sweden)

    Patten Scott B


    Full Text Available Abstract Background Major depression is a widely used diagnostic category but there is increasing dissatisfaction with its performance. The diathesis-stress model is an alternative approach that does not require the (sometimes arbitrary imposition of categories onto the spectrum of depressive morbidity. However, application of this model has not been well explored and its consistency with available epidemiologic data is uncertain. Methods Simulation provides an opportunity to explore these issues. In this study, a simulation model based on an intuitive representation of diathesis-stress interaction was developed. Both diathesis and stress were represented using continuous distributions, without categorization. A diagnostic threshold was then applied to the simulation output to create nominal categories and to explore their consistency with available information. Results An apparently complex epidemiologic pattern emerged from the diathesis-stress interaction when thresholds were applied: incidence was time dependent, recurrence depended on the number of past episodes, baseline symptoms were associated with an increased risk of subsequent episodes and the remission rate declined with increasing episode duration. Conclusions A diathesis-stress conceptualization coupled with application of a threshold-based diagnostic definition may explain several of the apparent complexities of major depression epidemiology. Some of these complexities may be artifacts of the nominal diagnostic approach. These observations should encourage an empirical exploration of whether diathesis-stress interactions provide a more parsimonious framework for understanding depression than current approaches.

  1. The epidemiology of mental illness in Afro-Americans. (United States)

    Williams, D H


    The epidemiologic study of mental illness among Afro-Americans has progressed since the antebellum period when the rate of mental illness among free Afro-Americans living in the North was inflated to justify continued slavery. Community-wide surveys conducted after World War II demonstrated that when socioeconomic variables were controlled, the rate of mental illness among Afro-Americans was no higher than that of other groups. The rates of mental illness and substance abuse of Afro-Americans vary according to socioeconomic class and are also related to differential family structure, early performance in school, and antisocial behavior of fathers. Despite progress, undersampling of middle-class Afro-Americans and poor, unemployed, young, urban Afro-American males are consistent deficiencies of surveys that even the ambitious NIMH Epidemiologic Catchment Area Program seems to share.

  2. Applied mechanics of solids

    CERN Document Server

    Bower, Allan F


    Modern computer simulations make stress analysis easy. As they continue to replace classical mathematical methods of analysis, these software programs require users to have a solid understanding of the fundamental principles on which they are based. Develop Intuitive Ability to Identify and Avoid Physically Meaningless Predictions Applied Mechanics of Solids is a powerful tool for understanding how to take advantage of these revolutionary computer advances in the field of solid mechanics. Beginning with a description of the physical and mathematical laws that govern deformation in solids, the text presents modern constitutive equations, as well as analytical and computational methods of stress analysis and fracture mechanics. It also addresses the nonlinear theory of deformable rods, membranes, plates, and shells, and solutions to important boundary and initial value problems in solid mechanics. The author uses the step-by-step manner of a blackboard lecture to explain problem solving methods, often providing...

  3. 34 CFR 661.3 - What regulations apply? (United States)


    ..., DEPARTMENT OF EDUCATION BUSINESS AND INTERNATIONAL EDUCATION PROGRAM General § 661.3 What regulations apply? The following regulations apply to this program: (a) The regulations in 34 CFR part 655. (b)...

  4. β-Lactam Resistance Genes: Characterization, Epidemiology, and First Detection of blaCTX-M-1 and blaCTX-M-14 in Salmonella spp. Isolated from Poultry in Brazil-Brazil Ministry of Agriculture's Pathogen Reduction Program. (United States)

    Fitch, Fernanda Marques; Carmo-Rodrigues, Mirian Silva; Oliveira, Vinicius Gomes Sales; Gaspari, Marcus Vinicius; Dos Santos, Amaury; de Freitas, Josinete Barros; Pignatari, Antonio C C


    Salmonella spp. are widespread in nature; however, human infections occur mainly through ingestion of contaminated food, specially poultry and eggs. In Brazil, the Ministry of Agriculture (MAPA) oversees food production in general, with the goal of preventing transmission of pathogens through the food chain. In 2004, MAPA initiated a program to monitor and control levels of Salmonella in poultry during slaughter. This study analyzes isolates from MAPA's program for β-lactam resistance and the resistance genes involved, as well as the geographic distributions of potentially clonal populations of resistant isolates within Brazil. Initially, 1,939 Salmonella spp. isolated between 2004 and 2011 were examined. These isolates were tested for antimicrobial susceptibility, and 100 isolates resistant or intermediate to ampicillin and ceftriaxone were screened initially for the presence of blaSHV, blaTEM, blaOXA, blaPSA, blaCMY-1, and blaCMY-2 genes. There were 55 isolates whose resistance genes were not identified by this panel and these isolates are the subject of this report. These 55 isolates were differentiated into 31 distinct ribogroups, with multiple β-lactam resistance genes, including AmpC blaCMY, blaTEM, blaCTX-M-1, blaCTX-M-2, blaCTX-M-8, and blaCTX-M-14. Isolates carrying variants of blaCTX-M were identified in three geographic regions. Salmonella carrying particular genetic variants of blaCTX-M and belonging to the same ribogroup were identified from multiple poultry slaughtering facilities. In some instances, these presumptive clonal-related isolates were from facilities over 300 miles apart, indicating potential clonal spread between two geographic regions. This is the first report of blaCTX-M-1 and blaCTX-M-14 in Salmonella in Brazil.

  5. The Applied Connection for Sociology. (United States)

    Boros, Alexander


    A survey of the 76 graduates of Kent State's applied sociology masters program, designed to prepare students for employment outside academe, found one graduate employed outside her field, four who continued their education and became practicing sociologists, and a majority who used their training as human service practitioners. (MSE)

  6. Epidemiology, molecular epidemiology, and risk factors for renal cell carcinoma

    Directory of Open Access Journals (Sweden)

    Chiara Paglino


    Full Text Available Despite only accounting for approximately 2% of all new primary cancer cases, renal cell carcinoma (RCC incidence has dramatically increased over time. Incidence rates vary greatly according to geographic areas, so that it is extremely likely that exogenous risk factors could play an important role in the development of this cancer. Several risk factors have been linked with RCC, including cigarette smoking, obesity, hypertension (and antihypertensive drugs, chronic kidney diseases (also dialysis and transplantation, as well as the use of certain analgesics. Furthermore, although RCC has not generally been considered an occupational cancer, several types of occupationally-derived exposures have been implicated in its pathogenesis. These include exposure to asbestos, chlorinated solvents, gasoline, diesel exhaust fumes, polycyclic aromatic hydrocarbons, printing inks and dyes, cadmium and lead. Finally, families with a predisposition to the development of renal neoplasms were identified and the genes involved discovered and characterized. Therefore, there are now four well-characterized, genetically determined syndromes associated with an increased incidence of kidney tumors, i.e., Von Hippel Lindau (VHL, Hereditary Papillary Renal Carcinoma (HPRC, Birt-Hogg-Dubé Syndrome (BHD, and Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC. This review will address present knowledge about the epidemiology, molecular epidemiology and risk factors of RCC.

  7. Genetic epidemiological study of schizophrenia: reproduction behaviour. (United States)

    Ritsner, M; Sherina, O; Ginath, Y


    Data from the Tomsk Epidemiological Register and epidemiological family sample were used to study the relationship between schizophrenics' reproductive behaviour (marital status and fertility rate), severity of ICD-9 schizophrenia and risk of illness among relatives of probands. The results are interpreted in terms of multifactorial threshold and single monolocus models. Their importance for the interpretation of epidemiological data (a change of prevalence rate, cohort effect and clinical polymorphism) is discussed.

  8. Integrative cancer epidemiology--the next generation. (United States)

    Spitz, Margaret R; Caporaso, Neil E; Sellers, Thomas A


    We outline an integrative approach to extend the boundaries of molecular cancer epidemiology by integrating modern and rapidly evolving "omics" technologies into state-of-the-art molecular epidemiology. In this way, one can comprehensively explore the mechanistic underpinnings of epidemiologic observations in cancer risk and outcome. We highlight the exciting opportunities to collaborate across large observational studies and to forge new interdisciplinary collaborative ventures.

  9. Applying Nonlinear Programming to Solve Optimal Control for Soft Landing of Lunar Probe%应用非线性规划求解月球探测器着陆轨道最优控制

    Institute of Scientific and Technical Information of China (English)



    In order to decrease the fuel consumption under a finite thrust, a method of nonlinear program-ming is presented to solve the optimal control problem on the soft landing of a lunar probe.The lunar soft land-ing problem is transformed into a two point boundary value problem in mathematics.In consideration of the bound condition, applying on Lagrang principle, the two-point boundary value problem is converted into a pa-rameter optimization problem.The simulated result demonstrates that the proposed method leads to a success-ful implementation of the lunar soft landing, which shows that the proposed design scheme is effective.%为了减少有限推力作用下月球探测器软着陆所需的燃料消耗,提出了应用非线性规划方法来求解该最优控制问题。首先,将有限推力作用下月球软着陆问题转化为数学上的两点边值问题;在考虑边界条件的前提下,利用拉格朗日原理将该两点边值问题转化为针对控制变量的优化问题;然后应用非线性规划方法求解所形成的参数优化问题。实验仿真结果显示,该方法能够成功实现月面软着陆,表明提出的设计方法简单有效。

  10. Epidemiology. (United States)

    Walsh, Kyle M; Ohgaki, Hiroko; Wrensch, Margaret R


    More than 250,000 new cases of primary malignant brain tumors are diagnosed annually worldwide, 77% of which are gliomas. A small proportion of gliomas are caused by the inheritance of rare high-penetrance genetic variants or high-dose radiation. Since 2009, inherited genetic variants in 10 regions near eight different genes have been consistently associated with glioma risk via genome-wide association studies. Most of these variants increase glioma risk by 20-40%, but two have higher relative risks. One on chromosome 8 increases risk of IDH-mutated gliomas sixfold and another that affects TP53 function confers a 2.5-fold increased risk of glioma. Functions of some of the other risk variants are known or suspected, but future research will determine functions of other risk loci. Recent progress also has been made in defining subgroups of glioma based on acquired alterations within tumors. Allergy history has been consistently associated with reduced glioma risk, though the mechanisms have not yet been clarified. Future studies will need to be large enough so that environmental and constitutive genetic risk factors can be examined within molecularly defined, etiologically homogeneous subgroups.

  11. Epidemiology of recurrent venous thrombosis

    Directory of Open Access Journals (Sweden)

    D.D. Ribeiro


    Full Text Available Venous thrombosis, including deep vein thrombosis and pulmonary embolism, is a common disease that frequently recurs. Recurrence can be prevented by anticoagulants, but this comes at the risk of bleeding. Therefore, assessment of the risk of recurrence is important to balance the risks and benefits of anticoagulant treatment. This review briefly outlines what is currently known about the epidemiology of recurrent venous thrombosis, and focuses in more detail on potential new risk factors for venous recurrence. The general implications of these findings in patient management are discussed.

  12. Epidemiological investigation of esophageal carcinoma

    Institute of Scientific and Technical Information of China (English)

    Hong Zhang; Shao-Hua Chen; You-Ming Li


    AIM: To review the characteristics of esophageal carcinoma in recent 30 years in the epidemiological investigation.METHODS: A total of 1 520 cases of esophageal carcinoma in the First Affiliated Hospital of Zhejiang University Medical College admitted from 1970 until now were reviewed. Their age, gender, position of carcinoma and histological type were analyzed.RESULTS: The morbidity of esophageal carcinoma was increasing during the observation period. Compared with the 1970s (9.5%), the ratio of adenocarcinoma significantly increased after the 1980s (19.1%). The difference was significant (P≤0.05).CONCLUSION: The morbidity of esophageal adenocarcinoma was increasing and advanced clinical study should be strengthened.

  13. An introduction to mathematical epidemiology

    CERN Document Server

    Martcheva, Maia


    The book is a comprehensive, self-contained introduction to the mathematical modeling and analysis of infectious diseases. It includes model building, fitting to data, local and global analysis techniques. Various types of deterministic dynamical models are considered: ordinary differential equation models, delay-differential equation models, difference equation models, age-structured PDE models and diffusion models. It includes various techniques for the computation of the basic reproduction number as well as approaches to the epidemiological interpretation of the reproduction number. MATLAB code is included to facilitate the data fitting and the simulation with age-structured models.

  14. Intrathoracic neoplasia: Epidemiology and etiology

    Energy Technology Data Exchange (ETDEWEB)

    Weller, R.E.


    Neoplasms of the thorax encompass those derived from the thoracic wall, trachea, mediastinum, lungs and pleura. They represent a wide variety of lesions including benign and malignant tumors arising from many tissues. The large surface area, 60 to 90 m{sup 2} in man, represented by the respiratory epithelium and associated thoracic structures are ideal targets for carcinogens carried by inspired air. The topic of discussion in this report is the epidemiology, etiology, and mechanisms of spontaneous intrathoracic neoplasia in animals and man. Much of what we know or suspect about thoracic neoplasia in animals has been extrapolated from experimentally-induced neoplasms.

  15. Epidemiology of Ciguatera in Florida


    Radke, Elizabeth G.; Reich, Andrew; Morris, John Glenn


    Ciguatera is the most commonly reported marine food-borne illness worldwide. Because there is a biological plausibility that ciguatera may be impacted by long-term climate variability and Florida is on the northern border of the geographic distribution of ciguatera, it is important to update our understanding of its epidemiology in Florida. We performed an analysis of 291 reports in Florida from 2000 to 2011 and an e-mail survey of 5,352 recreational fishers to estimate incidence and underrep...

  16. Epidemiology of Autoimmune Bullous Diseases

    Directory of Open Access Journals (Sweden)

    Erkan Alpsoy


    Full Text Available We have very limited knowledge about aotuimmune bullous disesases which are important causes of morbidity and mortality. They are generally rare disases in population. The yearly over all incidences of pemphigus and bullous pemhigoid are between 0.5 to 16.1/million and 2.5 to 42.8/million, respectively. Pemphigus vulgaris is the major type of pemphigus and it is most prevalent between ages of 40 and 50. Bullous pemphigoid is tpypically most prevalent in ages of over 70. In this review the results obtained from the studies which are especially about epidemiology of pemphigus and bullous pemphigoid were analised according to geographic regions.

  17. Genetics and epidemiology, congenital anomalies and cancer

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, J.M. [Univ. of British Columbia, Vancouver (Canada)


    Many of the basic statistical methods used in epidemiology - regression, analysis of variance, and estimation of relative risk, for example - originally were developed for the genetic analysis of biometric data. The familiarity that many geneticists have with this methodology has helped geneticists to understand and accept genetic epidemiology as a scientific discipline. It worth noting, however, that most of the work in genetic epidemiology during the past decade has been devoted to linkage and other family studies, rather than to population-based investigations of the type that characterize much of mainstream epidemiology. 30 refs., 2 tabs.

  18. Effective Programming

    DEFF Research Database (Denmark)

    Frost, Jacob

    To investigate the use of VTLoE as a basis for formal derivation of functional programs with effects. As a part of the process, a number of issues central to effective formal programming are considered. In particular it is considered how to develop a proof system suitable for pratical reasoning......, how to implement this system in the generic proof assistant Isabelle and finally how to apply the logic and the implementation to programming....

  19. The household contact study design for genetic epidemiological studies of infectious diseases

    Directory of Open Access Journals (Sweden)

    Catherine eStein


    Full Text Available Most genetic epidemiological study designs fall into one of two categories: family-based and population-based (case-control. However, recent advances in statistical genetics call for study designs that combine these two approaches. We describe the household contact study design as we have applied it in our several years of study of the epidemiology of tuberculosis. Though we highlight its applicability for genetic epidemiological studies of infectious diseases, there are many facets of this design that are appealing for modern genetic studies, including the simultaneous enrollment of related and unrelated individuals, closely and distantly related individuals, collection of extensive epidemiologic and phenotypic data, and evaluation of effects of shared environment and gene by environment interaction. These study design characteristics are particularly appealing for current sequencing studies.

  20. Western Perspectives in Applied Linguistics in Africa (United States)

    Makoni, Sinfree; Meinhof, Ulrike H.


    The aim of this article is to analyze the nature of the historical and contemporary social contexts within which applied linguistics in Africa emerged, and is currently practiced. The article examines the challenges "local" applied Linguistics in Africa is confronted with as it tries to amplify applied linguistic programs emanating from…

  1. Estudos epidemiológicos na avaliação de efetividade do Programa de Controle da Doença de Chagas: discussão metodológica Epidemiological studies for evaluating the effectiveness of the Chagas' Disease Control Program: a discussion on methods

    Directory of Open Access Journals (Sweden)

    Mariângela Carneiro


    ão éticos, pois são implementados durante a execução dos programas; permitem inferência de relação causa-efeito; são viáveis do ponto de vista operacional, podendo ser incluídos na fase de planejamento de programas de saúde.The present paper describes the methodological aspects of different epidemiological designs tested as a model to evaluate the effectiveness of the Chagas' disease control program. The main outcome was the reduction of infection rates by Trypanosam cruzi (etiological agent measured by serology, in those born after the intervention. The actions of Chagas' disease control programs were based on house spraying with insecticide with the objective of controlling the vector Triatoma infestans (intermediate hosts of T. cruzi. The epidemiological designs used were: 1 Quasi-experimental, conducted in 1987, when an area for comparison was available. The reduction of T. cruzi infection rates in the area where intervention had been carried out for 5 and 10 years was compared with those where there was no intervention (control. The program effectiveness was estimated by comparing the infection rates found in the study with those published by the Chagas' disease serological survey (1975-1980; 2 Panel study, conducted in one area with 13 years of intervention. The objectives were to investigate the T. cruzi infection transmission pattern in a cohort born after the intervention and to verify whether the duration of the program was a determinant factor in inducing change in the incidence. The reduction of T. cruzi infection rates was estimated from data collected on three separate occasions: a national serological survey (1975-80, a quasi-experimental study (1987 and the present investigation (1995; 3 Nested case-control, to evaluate the risk factors of T.cruzi infection, incorporated within a serological survey of school children, which was implemented by the National Health Foundation to evaluate the effectiveness of the Chagas' disease control program

  2. Suicide and attempted suicide: epidemiological surveillance as a crucial means of a local suicide prevention project in Trento's Province. (United States)

    Di Napoli, Wilma Angela; Della Rosa, Alberto


    The World Health Organization identifies suicide among the top 10 causes of death in many countries with an overall mortality rate of 16 per 100,000 inhabitants. Furthermore suicide attempts present a frequency 4-10 times greater than the suicidal events, representing also one of the main risk factors to lead to recurrent attempts of suicide. In 2008 the Autonomous Province of Trento launched a suicide prevention pogram called "Invitation to Life" which includes various interventions intended to counter the phenomenon of suicide in the region. Actually the epidemiological research upon the phenomenon of suicide in Trentino region is one of the main pillars of the project: it represents a fundamental requirement to identify risk and protective factors in the population in order to adopt more specific and effective preventive strategies. This article aims to present methods and instruments for epidemiological monitoring of suicide and attempted suicide which are applied in Trentino and to describe results after seven years from the beginning of the local prevention program "Invitation to life".

  3. Web-based public health geographic information systems for resources-constrained environment using scalable vector graphics technology: a proof of concept applied to the expanded program on immunization data

    Directory of Open Access Journals (Sweden)

    Kamadjeu Raoul


    Full Text Available Abstract Background Geographic Information Systems (GIS are powerful communication tools for public health. However, using GIS requires considerable skill and, for this reason, is sometimes limited to experts. Web-based GIS has emerged as a solution to allow a wider audience to have access to geospatial information. Unfortunately the cost of implementing proprietary solutions may be a limiting factor in the adoption of a public health GIS in a resource-constrained environment. Scalable Vector Graphics (SVG is used to define vector-based graphics for the internet using XML (eXtensible Markup Language; it is an open, platform-independent standard maintained by the World Wide Web Consortium (W3C since 2003. In this paper, we summarize our methodology and demonstrate the potential of this free and open standard to contribute to the dissemination of Expanded Program on Immunization (EPI information by providing interactive maps to a wider audience through the Internet. Results We used SVG to develop a database driven web-based GIS applied to EPI data from three countries of WHO AFRO (World Health Organization – African Region. The system generates interactive district-level country immunization coverage maps and graphs. The approach we describe can be expanded to cover other public health GIS demanding activities, including the design of disease atlases in a resources-constrained environment. Conclusion Our system contributes to accumulating evidence demonstrating the potential of SVG technology to develop web-based public health GIS in resources-constrained settings.

  4. [Epidemiology of acromegaly in Spain]. (United States)

    Sesmilo, Gemma


    Epidemiology of acromegaly in Spain does not differ from that reported in other published series. Prevalence rate is approximately 60 cases per million, peak incidence occurs in middle age, more women are affected (61%), and there is a substantial delay between occurrence of the first symptoms and diagnosis. Studies REA (Spanish Acromegaly Registry) and OASIS analyzed the epidemiology, clinical characteristics, and management of the disease in Spain. Surgery, performed in more than 80% of patients, has been (and continues to be) the main treatment for the past four decades. In the past decade, however, more patients have received somatostatin analogs (SSAs) as first-line treatment. Use of radiation therapy has significantly decreased in recent decades. Somatostatin analogs (SSAs) are the most commonly used drugs, administered to 85% of patients; however, only 12%-15% continue on drug treatment alone. The surgical remission rate was 38.4% in the last decade, with a significant improvement over decades. Preoperative treatment with SSAs has no influence on surgical cure rates. Second-line therapies used after surgical failure in the past decade included SSAs in 49% of patients, repeat surgery in 27%, radiotherapy in 11%, pegvisomant in 15%, and dopamine agonists in 5%. Mean cost of acromegaly treatment was 9.668€ (data estimated in 2009 and adjusted in 2010), of which 71% was due to the cost of SSAs. Patients treated with pegvisomant have a more aggressive form of the disease and higher comorbidity rates.

  5. en epidemiología

    Directory of Open Access Journals (Sweden)

    Ana V. Diez Roux


    Full Text Available La epidemiología sociocultural se caracteriza por la integración de procesos sociales, culturales, económicos y políticos con procesos biológicos en el estudio de los determinantes de la salud. Por definición, esto implica la consideración de determinantes especificados a múltiples niveles, desde los genes hasta las características de la sociedad en su totalidad. En este artículo se analizan diversos problemas metodológicos que surgen en epidemiología (y en las ciencias sociales en general por la presencia de múltiples niveles de organización que pueden ser relevantes para entender las causas de la salud y la enfermedad. Se subraya la necesidad de investigar conjuntamente (o de integrar determinantes de la salud definidos a distintos niveles. El artículo concluye con un examen de las implicaciones de la presencia de múltiples niveles para el estudio de los determinantes sociales o culturales de la salud.

  6. Epidemiology: second-rate science? (United States)

    Parascandola, M


    In recent years epidemiology has come under increasing criticism in regulatory and public arenas for being "unscientific." The tobacco industry has taken advantage of this, insisting for decades that evidence linking cigarettes and lung cancer falls short of proof. Moreover, many epidemiologists remain unduly skeptical and self-conscious about the status of their own causal claims. This situation persists in part because of a widespread belief that only the laboratory can provide evidence sufficient for scientific proof. Adherents of this view erroneously believe that there is no element of uncertainty or inductive inference in the "direct observation" of the laboratory researcher and that epidemiology provides mere "circumstantial" evidence. The historical roots of this attitude can be traced to philosopher John Stuart Mill and physiologist Claude Bernard and their influence on modern experimental thinking. The author uses the debate over cigarettes and lung cancer to examine ideas of proof in medical science and public health, concluding that inductive inference from a limited sample to a larger population is an element in all empirical science.

  7. Epidemiology of Brucellosis and Genetic Diversity of Brucella abortus in Kazakhstan (United States)

    Shevtsova, Elena; Shevtsov, Alexandr; Mukanov, Kasim; Filipenko, Maxim; Kamalova, Dinara; Sytnik, Igor; Syzdykov, Marat; Kuznetsov, Andrey; Akhmetova, Assel; Zharova, Mira; Karibaev, Talgat; Tarlykov, Pavel; Ramanculov, Erlan


    Brucellosis is a major zoonotic infection in Kazakhstan. However, there is limited data on its incidence in humans and animals, and the genetic diversity of prevalent strains is virtually unstudied. Additionally, there is no detailed overview of Kazakhstan brucellosis control and eradication programs. Here, we analyzed brucellosis epidemiological data, and assessed the effectiveness of eradication strategies employed over the past 70 years to counteract this infection. We also conducted multiple loci variable-number tandem repeat analysis (MLVA) of Brucella abortus strains found in Kazakhstan. We analyzed official data on the incidence of animal brucellosis in Kazakhstan. The records span more than 70 years of anti-brucellosis campaigns, and contain a brief description of the applied control strategies, their effectiveness, and their impact on the incidence in humans. The MLVA-16 method was used to type 94 strains of B. abortus and serial passages of B. abortus 82, a strain used in vaccines. MLVA-8 and MLVA-11 analyses clustered strains into a total of four and seven genotypes, respectively; it is the first time that four of these genotypes have been described. MLVA-16 analysis divided strains into 28 distinct genotypes having genetic similarity coefficient that varies from 60 to100% and a Hunter & Gaston diversity index of 0.871. MST analysis reconstruction revealed clustering into "Kazakhstani-Chinese (Central Asian)", "European" and "American" lines. Detection of multiple genotypes in a single outbreak confirms that poorly controlled trade of livestock plays a crucial role in the spread of infection. Notably, the MLVA-16 profile of the B. abortus 82 strain was unique and did not change during 33 serial passages. MLVA genotyping may thus be useful for epidemiological monitoring of brucellosis, and for tracking the source(s) of infection. We suggest that countrywide application of MLVA genotyping would improve the control of brucellosis in Kazakhstan. PMID

  8. Epidemiology, diagnosis and management of food allergy

    NARCIS (Netherlands)

    Le, T.T.M.


    This thesis describes the epidemiology, diagnosis and management of food allergy. Epidemiology This thesis shows that the prevalence of self-reported adverse food reactions in children and adults was high: 17-25% for all foods and 10-11% for 24 preselected, so-called priority foods. The prevalence o

  9. Epidemiology of traumatic brain injury in Europe

    NARCIS (Netherlands)

    W. Peeters (Wouter); R. van den Brande (Ruben); S. Polinder (Suzanne); A. Brazinova (Alexandra); E.W. Steyerberg (Ewout); H.F. Lingsma (Hester); A.I.R. Maas (Andrew)


    textabstractBackground: Traumatic brain injury (TBI) is a critical public health and socio-economic problem throughout the world, making epidemiological monitoring of incidence, prevalence and outcome of TBI necessary. We aimed to describe the epidemiology of traumatic brain injury in Europe and to

  10. Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC resistance

    Directory of Open Access Journals (Sweden)

    Chen LF


    Full Text Available Luke F Chen,1–4 Deverick J Anderson,1–4 David L Paterson51Duke Program for Infection Prevention and Healthcare Epidemiology, 2Duke Infection Control Outreach Network, 3Duke University Prevention Epicenter Program, 4Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA; 5University of Queensland Centre for Clinical Research (UQCCR, Royal Brisbane and Women's Hospital Campus, Brisbane, AustraliaAbstract: Klebsiella pneumoniae carbapenemases (KPCs confer resistance to nearly all ß-lactams. This broad-spectrum drug resistance mechanism has rapidly spread in the United States and is reportedly increasing elsewhere in the world. Thus, the emergence of KPC resistance is a major threat to global health. This article reviews the epidemiology and provides an overview of the dissemination of KPC-producing organisms.Keywords: beta-lactam resistance, carbapenemase, drug resistance, epidemiology, treatment failure

  11. [Epidemiologic surveillance for the prevention and control urban violence]. (United States)

    Concha-Eastman, A; Guerrero, R


    Violence prevention policies should be based on information, follow-up, research, and analysis, all of which increase the chances of success and make it easier to evaluate interventions. This implies, in turn, that there is a need to create surveillance, research, and prevention models for violence within the sphere of public health and epidemiology, a task that constitutes an integral part of the Pan American Health Organization's Regional Plan of Action Health and Violence. This article describes the objectives of epidemiologic surveillance systems and explains their purpose and scope, along with the barriers that stand in the way of their implementation. It also examines a number of variables and their definitions, the types of analyses and reports that should be generated, and the decisions that can be made on the basis of these reports. Finally, it discusses ethical criteria and describes the experiences of the program known as Desarrollo, Seguridad y Paz (DESEPAZ) in Cali and Santa Fe de Bogota, Colombia, where an epidemiologic surveillance system against violence has been implemented.

  12. Molecular Epidemiology of Hemoglobinopathies in Cambodia. (United States)

    Munkongdee, Thongperm; Tanakulmas, Jatuporn; Butthep, Punnee; Winichagoon, Pranee; Main, Barbara; Yiannakis, Miriam; George, Joby; Devenish, Robyn; Fucharoen, Suthat; Svasti, Saovaros


    Determining the magnitude of the thalassemia problem in a country is important for implementing a national prevention and control program. In order to acquire accurate thalassemia prevalence data, the gene frequency of α- and β-thalassemia (α- and β-thal) in different regions of a country should be determined. The molecular basis of thalassemia in Cambodia was performed by polymerase chain reaction (PCR)-based techniques in a community-based cross-sectional survey of 1631 unrelated individuals from three regions, Battambang, Preah Vihear and Phnom Penh. Thalassemia mutations were detected in 62.7% of the three studied population of Cambodia. Hb E (HBB: c.79G > A) was the most common β-globin gene mutation with a frequency ranging from 0.139 to 0.331, while the most frequent α-globin gene mutation was the -α(3.7) (rightward) deletion (0.098-0.255). The other frequencies were 0.001-0.003 for β-thal, 0.008-0.011 for α-thal-1 (- -(SEA)), 0.003-0.008 for α-thal-2 [-α(4.2) (leftward deletion)], 0.021-0.044 for Hb Constant Spring (Hb CS, HBA2: c.427T > C) and 0.009-0.036 for Hb Paksé (HBA2: c.429A > T). A regional specific thalassemia gene frequency was observed. Preah Vihear had the highest prevalence of Hb E (55.9%), α-thal-2 (24.0%) and nondeletional α-thal (15.1%), whereas Phnom Penh had the lowest frequency of thalassemia genes. Interestingly, in Preah Vihear, the frequency of Hb Paksé was extremely high (0.036), almost equivalent to that of Hb CS (0.044). Our results indicate the importance of micromapping and epidemiology studies of thalassemia, which will assist in establishing the national prevention and control program in Cambodia.

  13. Epidemiological studies of oral cancer. (United States)

    Pindborg, J J


    The FDI has shown considerable interest in the oral cancer and has in recent years arranged three symposia on the subject. The incidence of oral cancer shows marked geographic differences mostly depending upon environmental factors. In the present paper the epidemiology of oral cancer is illustrated by the relative frequency to total number of cancers and incidence rates from a number of countries. Canada has the highest rate of cancer of the vermilion border, which is extremely rare among dark-skinned people. Even within one country differences may be found, a fact which is illustrated by findings from Czechoslovakia and India. In most of the studies dealing with the etiology of oral cancer tobacco usage in its various forms is shown to be the outstanding factor.

  14. Epidemiological characteristics of gastric cancer

    Directory of Open Access Journals (Sweden)

    Šipetić Sandra B.


    Full Text Available Introduction. Gastric cancer was the third most common cancer worldwide in 2000, accounting for approximately 876 000 new cases or 9% of the global cancer burden. Epidemiological characteristics As a result of changes in diet, the incidence of gastric cancer has decreased in most countries. Now days, consumption of fresh vegetables and fruits is increasing in regard to canned food. In addition to unhealthy diet, the main risk factors for gastric cancer are H. pylori infection, alcohol consumption, smoking, gastritis, stomach ulcer, gastrectomy, stomach polyposis, positive family history for gastric cancer, pernicious anemia and blood type A. Diet rich in vegetables and fruits, and reduced salt intake can prevent 65-75% of gastric cancer cases among nonsmokers. Prevention of Helicobacter pylori infection can also reduce the incidence of this malignant disease. .

  15. Epidemiology of Haemophilus ducreyi Infections. (United States)

    González-Beiras, Camila; Marks, Michael; Chen, Cheng Y; Roberts, Sally; Mitjà, Oriol


    The global epidemiology of Haemophilus ducreyi infections is poorly documented because of difficulties in confirming microbiological diagnoses. We evaluated published data on the proportion of genital and nongenital skin ulcers caused by H. ducreyi before and after introduction of syndromic management for genital ulcer disease (GUD). Before 2000, the proportion of GUD caused by H. ducreyi ranged from 0.0% to 69.0% (35 studies in 25 countries). After 2000, the proportion ranged from 0.0% to 15.0% (14 studies in 13 countries). In contrast, H. ducreyi has been recently identified as a causative agent of skin ulcers in children in the tropical regions; proportions ranged from 9.0% to 60.0% (6 studies in 4 countries). We conclude that, although there has been a sustained reduction in the proportion of GUD caused by H. ducreyi, this bacterium is increasingly recognized as a major cause of nongenital cutaneous ulcers.

  16. Epidemiology and treatment of mucormycosis. (United States)

    Lewis, Russell E; Kontoyiannis, Dimitrios P


    Mucormycosis is an uncommon but aggressive opportunistic fungal infection that afflicts patients with severe underlying immunosuppression, uncontrolled hyperglycemia and/or ketoacidosis, patients with iron overload resulting from frequent blood transfusions or blood disorders and occasionally healthy patients who are inoculated with fungal spores through traumatic injuries. The clinical presentation of mucormycosis is initially indistinguishable from other common infections, and if not diagnosed early and aggressively treated, it is almost always fatal. In this article we summarize recent changes in the epidemiology of mucormycosis, discuss diagnostic and clinical clues suggestive of the infection and provide a general strategy for managing the infection in the absence of data from well-controlled, prospective clinical trials.

  17. Epidemiological survey of primary palmar hyperhidrosis in adolescents

    Institute of Scientific and Technical Information of China (English)

    LI Xu; CHEN Rong; TU Yuan-rong; LIN Min; LAI Fan-cai; LI Yue-ping; CHEN Jian-feng; YE Jian-gang


    Background Despite recent advances in recognition and treatment of primary palmar hyperhidrosis(PPH),the epidemiological survey has hardly been conducted.The aim of this study was to i.lvestigate the prevalence and epidemiological characteristics of primary PPH among adolescents in three cities of southeast China.Methods Stratified-cluster sampling was carried out and cross-sectional epidemiological survey by questionnaire was applied among 33 000 college and high schooJ students.Results The prevalence rate of PPH was 4.36% affecting both sexes equally.Prevalence rate of severe PPH was 0.27%.The average age of onset was 12.27±2.12 years.The peak age of onset was 6-16 years,accounting for 97.2% of PPH population.Positive family history was found in 17.9% PPH cases.Besides palms,axillae and soles can be also affected.Conclusions PPH affects a larger group of individual than previously reported.More measures should be taken to enhance the recognition,diagnosis,and treatment of PPH.

  18. Epidemiology of multiple chronic conditions: an international perspective

    Directory of Open Access Journals (Sweden)

    François G. Schellevis


    Full Text Available The epidemiology of multimorbidity, or multiple chronic conditions (MCCs, is one of the research priority areas of the U.S. Department of Health and Human Services (HHS by its Strategic Framework on MCCs. A conceptual model addressing methodological issues leading to a valid measurement of the prevalence rates of MCCs has been developed and applied in descriptive epidemiological studies. Comparing these results with those from prevalence studies performed earlier and in other countries is hampered by methodological limitations. Therefore, this paper aims to put the size and patterns of MCCs in the USA, as established within the HHS Strategic Framework on MCCs, in perspective of the findings on the prevalence of MCCs in other countries. General common trends can be observed: increasing prevalence rates with increasing age, and multimorbidity being the rule rather than the exception at old age. Most frequent combinations of chronic diseases include the most frequently occurring single chronic diseases. New descriptive epidemiological studies will probably not provide new results; therefore, future descriptive studies should focus on the prevalence rates of MCCs in subpopulations, statistical clustering of chronic conditions, and the development of the prevalence rates of MCCs over time. The finding of common trends also indicates the necessary transition to a next phase of MCC research, addressing the quality of care of patients with MCCs from an organizational perspective and with respect to the content of care.

  19. [Epidemiology and Public Health: tendencies of the Brazilian epidemiology production regarding volume, indexation and investigation areas - 2001 to 2006]. (United States)

    Turci, Silvana Rubano Barretto; Guilam, Maria Cristina Rodrigues; Câmara, Maria Clara Coelho


    This article examines and interprets the trends of epidemiological production in Brazil in the Public Health context. CAPES indicators from 2001 to 2006 were used as database. We analyzed 26 programs and select the 10 major ones to analyze their bibliographic production in indexed journals. It was observed that the total production of epidemiological articles accounted for 40% of production in Public Health and 55% of the production was published in international journals, especially Cadernos de Saúde Pública, Revista de Saúde Pública and Ciência & Saúde Coletiva. The most prevalent themes were public health nutrition, maternal and infant health and, infectious diseases, particularly AIDS. Environmental e worker's heath, oral health, violence and health of the elderly have been ratified as objects of study for the discipline, while meta-analysis and geoprocessing appear as a useful tool for health services. We conclude that the epidemiological production tends to increase in indexed publications, covering various topics and a wide spectrum of relevant issues to Brazilian health policy.

  20. Parameter Estimation in Epidemiology: from Simple to Complex Dynamics (United States)

    Aguiar, Maíra; Ballesteros, Sebastién; Boto, João Pedro; Kooi, Bob W.; Mateus, Luís; Stollenwerk, Nico


    We revisit the parameter estimation framework for population biological dynamical systems, and apply it to calibrate various models in epidemiology with empirical time series, namely influenza and dengue fever. When it comes to more complex models like multi-strain dynamics to describe the virus-host interaction in dengue fever, even most recently developed parameter estimation techniques, like maximum likelihood iterated filtering, come to their computational limits. However, the first results of parameter estimation with data on dengue fever from Thailand indicate a subtle interplay between stochasticity and deterministic skeleton. The deterministic system on its own already displays complex dynamics up to deterministic chaos and coexistence of multiple attractors.

  1. Epidemiological designs for vaccine safety assessment: methods and pitfalls. (United States)

    Andrews, Nick


    Three commonly used designs for vaccine safety assessment post licensure are cohort, case-control and self-controlled case series. These methods are often used with routine health databases and immunisation registries. This paper considers the issues that may arise when designing an epidemiological study, such as understanding the vaccine safety question, case definition and finding, limitations of data sources, uncontrolled confounding, and pitfalls that apply to the individual designs. The example of MMR and autism, where all three designs have been used, is presented to help consider these issues.

  2. Factorial and Discriminant Validity of the Center for Epidemiological Studies Depression (CES-D) Scale. (United States)

    Orme, John G.; And Others


    Examined the factorial and discriminant validity of the Center for Epidemiological Studies Depression (CES-D) scale for 116 parents participating in family support programs. Factorial validity was adequate, and results indicated a moderate correlation between the CES-D and self-esteem and state anxiety. However, a high correlation was obtained…

  3. Epidemiology of Pathogen-Specific Respiratory Infections Among Three US Populations (United States)


    establish baselines of infection, identify outbreaks, and help prioritize the development of new vaccines and future treatments. Epidemiology of Respiratory... vaccination programs, and possible investment in the development of future vaccines or treatments. Supporting Information S1 File. Tables S1 and S2...plans, establish baselines of infection, identify outbreaks, and help prioritize the development of new vaccines and future treatments. 15. SUBJECT

  4. Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014. (United States)

    Woehrer, Adelheid; Lau, Ching C; Prayer, Daniela; Bauchet, Luc; Rosenfeld, Myrna; Capper, David; Fisher, Paul G; Kool, Marcel; Müller, Martin; Kros, Johan M; Kruchko, Carol; Wiemels, Joseph; Wrensch, Margaret; Danysh, Heather E; Zouaoui, Sonia; Heck, Julia E; Johnson, Kimberly J; Qi, Xiaoyang; O'Neill, Brian P; Afzal, Samina; Scheurer, Michael E; Bainbridge, Matthew N; Nousome, Darryl; Bahassi, El Mustapha; Hainfellner, Johannes A; Barnholtz-Sloan, Jill S


    The Brain Tumor Epidemiology Consortium (BTEC) is an open scientific forum, which fosters the development of multi-center, international and inter-disciplinary collaborations. BTEC aims to develop a better understanding of the etiology, outcomes, and prevention of brain tumors ( The 15th annual Brain Tumor Epidemiology Consortium Meeting, hosted by the Austrian Societies of Neuropathology and Neuro-oncology, was held on September 9 - 11, 2014 in Vienna, Austria. The meeting focused on the central role of brain tumor epidemiology within multidisciplinary neuro-oncology. Knowledge of disease incidence, outcomes, as well as risk factors is fundamental to all fields involved in research and treatment of patients with brain tumors; thus, epidemiology constitutes an important link between disciplines, indeed the very hub. This was reflected by the scientific program, which included various sessions linking brain tumor epidemiology with clinical neuro-oncology, tissue-based research, and cancer registration. Renowned experts from Europe and the United States contributed their personal perspectives stimulating further group discussions. Several concrete action plans evolved for the group to move forward until next year's meeting, which will be held at the Mayo Clinic at Rochester, MN, USA.

  5. Brain Tumor Epidemiology – A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014 (United States)

    Woehrer, Adelheid; Lau, Ching C.; Prayer, Daniela; Bauchet, Luc; Rosenfeld, Myrna; Capper, David; Fisher, Paul G.; Kool, Marcel; Müller, Martin; Kros, Johan M.; Kruchko, Carol; Wiemels, Joseph; Wrensch, Margaret; Danysh, Heather E.; Zouaoui, Sonia; Heck, Julia E.; Johnson, Kimberly J.; Qi, Xiaoyang; O’Neill, Brian P.; Afzal, Samina; Scheurer, Michael E.; Bainbridge, Matthew N.; Nousome, Darryl; El Bahassi, Mustapha; Hainfellner, Johannes A.; Barnholtz-Sloan, Jill S.


    The Brain Tumor Epidemiology Consortium (BTEC) is an open scientific forum, which fosters the development of multi-center, international and inter-disciplinary collaborations. BTEC aims to develop a better understanding of the etiology, outcomes, and prevention of brain tumors ( The 15th annual Brain Tumor Epidemiology Consortium Meeting, hosted by the Austrian Societies of Neuropathology and Neuro-oncology, was held on September 9 – 11, 2014 in Vienna, Austria. The meeting focused on the central role of brain tumor epidemiology within multidisciplinary neuro-oncology. Knowledge of disease incidence, outcomes, as well as risk factors is fundamental to all fields involved in research and treatment of patients with brain tumors; thus, epidemiology constitutes an important link between disciplines, indeed the very hub. This was reflected by the scientific program, which included various sessions linking brain tumor epidemiology with clinical neuro-oncology, tissue-based research, and cancer registration. Renowned experts from Europe and the United States contributed their personal perspectives stimulating further group discussions. Several concrete action plans evolved for the group to move forward until next year’s meeting, which will be held at the Mayo Clinic at Rochester, MN, USA. PMID:25518914

  6. Geographical information system (GIS) as a new tool to evaluate epidemiology based on spatial analysis and clinical outcomes in acromegaly


    Naves, Luciana Ansaneli; Porto, Lara Benigno; Rosa, João Willy Corrêa; Casulari, Luiz Augusto; Rosa, José Wilson Corrêa


    Geographical information systems (GIS) have emerged as a group of innovative software components useful for projects in epidemiology and planning in Health Care System. This is an original study to investigate environmental and geographical influences on epidemiology of acromegaly in Brazil. We aimed to validate a method to link an acromegaly registry with a GIS mapping program, to describe the spatial distribution of patients, to identify disease clusters and to evaluate if the access to Hea...

  7. An animated depiction of major depression epidemiology

    Directory of Open Access Journals (Sweden)

    Patten Scott B


    Full Text Available Abstract Background Epidemiologic estimates are now available for a variety of parameters related to major depression epidemiology (incidence, prevalence, etc.. These estimates are potentially useful for policy and planning purposes, but it is first necessary that they be synthesized into a coherent picture of the epidemiology of the condition. Several attempts to do so have been made using mathematical modeling procedures. However, this information is not easy to communicate to users of epidemiological data (clinicians, administrators, policy makers. Methods In this study, up-to-date data on major depression epidemiology were integrated using a discrete event simulation model. The mathematical model was animated in Virtual Reality Modeling Language (VRML to create a visual, rather than mathematical, depiction of the epidemiology. Results Consistent with existing literature, the model highlights potential advantages of population health strategies that emphasize access to effective long-term treatment. The paper contains a web-link to the animation. Conclusion Visual animation of epidemiological results may be an effective knowledge translation tool. In clinical practice, such animations could potentially assist with patient education and enhanced long-term compliance.

  8. The contribution of molecular epidemiology to the understanding and control of viral diseases of salmonid aquaculture

    Directory of Open Access Journals (Sweden)

    Snow Michael


    Full Text Available Abstract Molecular epidemiology is a science which utilizes molecular biology to define the distribution of disease in a population (descriptive epidemiology and relies heavily on integration of traditional (or analytical epidemiological approaches to identify the etiological determinants of this distribution. The study of viral pathogens of aquaculture has provided many exciting opportunities to apply such tools. This review considers the extent to which molecular epidemiological studies have contributed to better understanding and control of disease in aquaculture, drawing on examples of viral diseases of salmonid fish of commercial significance including viral haemorrhagic septicaemia virus (VHSV, salmonid alphavirus (SAV and infectious salmon anaemia virus (ISAV. Significant outcomes of molecular epidemiological studies include: Improved taxonomic classification of viruses A better understanding of the natural distribution of viruses An improved understanding of the origins of viral pathogens in aquaculture An improved understanding of the risks of translocation of pathogens outwith their natural host range An increased ability to trace the source of new disease outbreaks Development of a basis for ensuring development of appropriate diagnostic tools An ability to classify isolates and thus target future research aimed at better understanding biological function While molecular epidemiological studies have no doubt already made a significant contribution in these areas, the advent of new technologies such as pyrosequencing heralds a quantum leap in the ability to generate descriptive molecular sequence data. The ability of molecular epidemiology to fulfil its potential to translate complex disease pathways into relevant fish health policy is thus unlikely to be limited by the generation of descriptive molecular markers. More likely, full realisation of the potential to better explain viral transmission pathways will be dependent on the

  9. EI: A Program for Ecological Inference

    Directory of Open Access Journals (Sweden)

    Gary King


    Full Text Available The program EI provides a method of inferring individual behavior from aggregate data. It implements the statistical procedures, diagnostics, and graphics from the book A Solution to the Ecological Inference Problem: Reconstructing Individual Behavior from Aggregate Data (King 1997. Ecological inference, as traditionally defined, is the process of using aggregate (i.e., "ecological" data to infer discrete individual-level relationships of interest when individual-level data are not available. Ecological inferences are required in political science research when individual-level surveys are unavailable (e.g., local or comparative electoral politics, unreliable (racial politics, insufficient (political geography, or infeasible (political history. They are also required in numerous areas of ma jor significance in public policy (e.g., for applying the Voting Rights Act and other academic disciplines ranging from epidemiology and marketing to sociology and quantitative history.

  10. Epidemiology of tobacco use and dependence. (United States)

    Giovino, G A; Henningfield, J E; Tomar, S L; Escobedo, L G; Slade, J


    Knowledge of the epidemiology of tobacco use and dependence can be used to guide research initiatives, intervention programs, and policy decisions. Both the reduction in the prevalence of smoking among US adults and black adolescents and the decline in per capita consumption are encouraging. These changes have probably been influenced by factors operating at the individual (e.g., school-based prevention programs and cessation programs) and environmental (e.g., mass media educational strategies, the presence of smoke-free laws and policies, and the price of tobacco products) levels (for a discussion of these factors, see, e.g., refs. 2, 48, 52, 183, and 184). The lack of progress among adolescents, especially whites and males, and the high risk for experimenters of developing tobacco dependence present cause for great concern (48, 183-186). In addition to those discussed above, several areas of research can be recommended. 1. Better understanding of the clustering of tobacco use with the use of other drugs, other risk behaviors, and other psychiatric disorders could better illuminate the causal processes involved, as well as the special features of the interventions needed to prevent and treat tobacco dependence. 2. To better understand population needs, trend analyses of prevalence, initiation, and cessation should, whenever possible, incorporate standardized measures of these other risk factors. Future research should compare the effect of socioeconomic status variables on measures of smoking behavior among racial/ethnic groups in the United States. 3. For reasons that may be genetic, environmental, or both, some persons do not progress beyond initial experimentation with tobacco use (2, 48, 183, 187-192), but about one-third to one-half of those who experiment with cigarettes become regular users (48, 193, 194). Factors, both individual and environmental, that can influence the susceptibility of individuals to tobacco dependence need further attention. 4. To

  11. Using Principles of Programmed Instruction (United States)

    Huffman, Harry


    Although programmed instruction in accounting is available, it is limited in scope and in acceptance. Teachers, however, may apply principles of programming to the individualizing of instruction. (Author)

  12. A large sustained endemic outbreak of multiresistant Pseudomonas aeruginosa: a new epidemiological scenario for nosocomial acquisition

    Directory of Open Access Journals (Sweden)

    Sora Mercedes


    Full Text Available Abstract Background Studies of recent hospital outbreaks caused by multiresistant P.aeruginosa (MRPA have often failed to identify a specific environmental reservoir. We describe an outbreak due to a single clone of multiresistant (MR Pseudomonas aeruginosa (PA and evaluate the effectiveness of the surveillance procedures and control measures applied. Methods Patients with MRPA isolates were prospectively identified (January 2006-May 2008. A combined surveillance procedure (environmental survey, and active surveillance program in intensive care units [ICUs] and an infection control strategy (closure of ICU and urology wards for decontamination, strict compliance with cross-transmission prevention protocols, and a program restricting the use of carbapenems in the ICUs was designed and implemented. Results Three hundred and ninety patients were identified. ICU patients were the most numerous group (22% followed by urology patients (18%. Environmental surveillance found that 3/19 (16% non-ICU environmental samples and 4/63 (6% ICU samples were positive for the MRPA clonal strain. In addition, active surveillance found that 19% of patients were fecal carriers of MRPA. Significant changes in the trends of incidence rates were noted after intervention 1 (reinforcement of cleaning procedures: -1.16 cases/1,000 patient-days (95%CI -1.86 to -0.46; p = 0.003 and intervention 2 (extensive decontamination: -1.36 cases/1,000 patient-days (95%CI -1.88 to -0.84; p Conclusions In the setting of sustained MRPA outbreaks, epidemiological findings suggest that patients may be a reservoir for further environmental contamination and cross-transmission. Although our control program was not successful in ending the outbreak, we think that our experience provides useful guidance for future approaches to this problem.

  13. Cancer epidemiology in the pacific islands - past, present and future. (United States)

    Moore, Malcolm A; Baumann, Francine; Foliaki, Sunia; Goodman, Marc T; Haddock, Robert; Maraka, Roger; Koroivueta, Josefa; Roder, David; Vinit, Thomas; Whippy, Helen J D; Sobue, Tomotaka


    The Pacific Ocean contains approximately 25,000 islands, stretching from Papua New Guinea to Easter Island, populated by mixtures of Melanesians, Micronesians and Polynesians, as well as migrant groups from Asia and Europe. The region encompasses a third of the surface of the earth although it is sparsely populated at a total of around 9 million. With the exception of some of the more populated islands, such as New Zealand and Hawaii, few surveys of chronic diseases have been conducted, but it is increasingly recognized that obesity, diabetes and associated conditions are emerging public health problems and clearly there is a need for cooperation to optimize control. Here we focus on cancer registry and epidemiological findings for Papua New Guinea, the Solomons, Vanuatu, Samoa, New Caledonia, Fiji, Polynesia, French Polynesia, Maori in New Zealand, Native Hawaiians, Micronesia, including Guam, and Aboriginal populations in Australia as assessed by PubMed searches and perusal of the International Agency for Cancer Research descriptive epidemiology database. Overall, the major cancers in males are oral and liver in Papua New Guinea and the Solomon Islands, and lung and prostate elsewhere (Fiji being exceptional in demonstrating a predominance of esophageal cancer), whereas in females it is breast and either cervix or lung, depending largely on whether cervical cancer screening program is active. In certain locations thyroid cancer is also very prevalent in females. The similarities and variation point to advantages for collaborative research to provide the evidence-base for effective cancer control programs in the region.

  14. Epilepsy in India I: Epidemiology and public health

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    Senthil Amudhan


    Full Text Available Of the 70 million persons with epilepsy (PWE worldwide, nearly 12 million PWE are expected to reside in India; which contributes to nearly one-sixth of the global burden. This paper (first of the two part series provides an in-depth understanding of the epidemiological aspects of epilepsy in India for developing effective public health prevention and control programs. The overall prevalence (3.0-11.9 per 1,000 population and incidence (0.2-0.6 per 1,000 population per year data from recent studies in India on general population are comparable to the rates of high-income countries (HICs despite marked variations in population characteristics and study methodologies. There is a differential distribution of epilepsy among various sociodemographic and economic groups with higher rates reported for the male gender, rural population, and low socioeconomic status. A changing pattern in the age-specific occurrence of epilepsy with preponderance towards the older age group is noticed due to sociodemographic and epidemiological transition. Neuroinfections, neurocysticercosis (NCC, and neurotrauma along with birth injuries have emerged as major risk factors for secondary epilepsy. Despite its varied etiology (unknown and known, majority of the epilepsy are manageable in nature. This paper emphasizes the need for focused and targeted programs based on a life-course perspective and calls for a stronger public health approach based on equity for prevention, control, and management of epilepsy in India.

  15. Epilepsy in India I: Epidemiology and public health (United States)

    Amudhan, Senthil; Gururaj, Gopalkrishna; Satishchandra, Parthasarathy


    Of the 70 million persons with epilepsy (PWE) worldwide, nearly 12 million PWE are expected to reside in India; which contributes to nearly one-sixth of the global burden. This paper (first of the two part series) provides an in-depth understanding of the epidemiological aspects of epilepsy in India for developing effective public health prevention and control programs. The overall prevalence (3.0-11.9 per 1,000 population) and incidence (0.2-0.6 per 1,000 population per year) data from recent studies in India on general population are comparable to the rates of high-income countries (HICs) despite marked variations in population characteristics and study methodologies. There is a differential distribution of epilepsy among various sociodemographic and economic groups with higher rates reported for the male gender, rural population, and low socioeconomic status. A changing pattern in the age-specific occurrence of epilepsy with preponderance towards the older age group is noticed due to sociodemographic and epidemiological transition. Neuroinfections, neurocysticercosis (NCC), and neurotrauma along with birth injuries have emerged as major risk factors for secondary epilepsy. Despite its varied etiology (unknown and known), majority of the epilepsy are manageable in nature. This paper emphasizes the need for focused and targeted programs based on a life-course perspective and calls for a stronger public health approach based on equity for prevention, control, and management of epilepsy in India. PMID:26425001

  16. Epidemiological features of brain tumors

    Directory of Open Access Journals (Sweden)

    Živković Nenad


    Full Text Available Brain tumors account for 1.4% of all cancers and 2.4% of all cancer-related deaths. The incidence of brain tumors varies and it is higher in developed countries of Western Europe, North America, Australia and New Zealand. In Serbia, according to data from 2009, malignant brain tumors account for 2. 2 of all tumors, and from all cancer­related deaths, 3.2% is caused by malignant brain tumors. According to recent statistical reports, an overall incidence of brain tumors for benign and malignant tumors combined is 18.71 per 100,000 persons/year. The most common benign brain tumor in adults is meningioma, which is most present in women, and the most common malignant tumor is glioblastoma, which is most present in adult men. Due to high mortality, especially in patients diagnosed with glioblastoma and significant brain tumor morbidity, there is a constant interest in understanding its etiology in order to possibly prevent tumor occurrence in future and enable more efficient treatment strategies for this fatal brain disease. Despite the continuously growing number of epidemiological studies on possible factors of tumor incidence, the etiology remains unclear. The only established environmental risk factor of gliomas is ionizing radiation exposure. Exposure to radiofrequency electromagnetic fields via cell phone use has gained a lot of attention as a potential risk factor of brain tumor development. However, studies have been inconsistent and inconclusive, so more definite results are still expected.

  17. The epidemiology of premature ejaculation. (United States)

    Saitz, Theodore Robert; Serefoglu, Ege Can


    Vast advances have occurred over the past decade with regards to understanding the epidemiology, pathophysiology and management of premature ejaculation (PE); however, we still have much to learn about this common sexual problem. As a standardized evidence-based definition of PE has only recently been established, the reported prevalence rates of PE prior to this definition have been difficult to interpret. As a result, a large range of conflicting prevalence rates have been reported. In addition to the lack of a standardized definition and operational criteria, the method of recruitment for study participation and method of data collection have obviously contributed to the broad range of reported prevalence rates. The new criteria and classification of PE will allow for continued research into the diverse phenomenology, etiology and pathogenesis of the disease to be conducted. While the absolute pathophysiology and true prevalence of PE remains unclear, developing a better understanding of the true prevalence of the disease will allow for the completion of more accurate analysis and treatment of the disease.

  18. Epidemiology of HBV subgenotypes D. (United States)

    Ozaras, Resat; Inanc Balkan, Ilker; Yemisen, Mucahit; Tabak, Fehmi


    The natural history of hepatitis B virus infection is not uniform and affected from several factors including, HBV genotype. Genotype D is a widely distributed genotype. Among genotype D, several subgenotypes differentiate epidemiologically and probably clinically. D1 is predominant in Middle East and North Africa, and characterized by early HBeAg seroconversion and low viral load. D2 is seen in Albania, Turkey, Brazil, western India, Lebanon, and Serbia. D3 was reported from Serbia, western India, and Indonesia. It is a predominant subgenotype in injection drug use-related acute HBV infections in Europe and Canada. D4 is relatively rare and reported from Haiti, Russia and Baltic region, Brazil, Kenya, Morocco and Rwanda. Subgenotype D5 seems to be common in Eastern India. D6 has been reported as a rare subgenotype from Indonesia, Kenya, Russia and Baltic region. D7 is the main genotype in Morocco and Tunisia. D8 and D9 are recently described subgenotypes and reported from Niger and India, respectively. Subgenotypes of genotype D may have clinical and/or viral differences. More subgenotype studies are required to conclude on subgenotype and its clinical/viral characteristics.

  19. Epidemiology of Helicobacter pylori infection. (United States)

    Leja, Mārcis; Axon, Anthony; Brenner, Hermann


    This review of recent publications related to the epidemiology of Helicobacter pylori highlights the origin of the infection, its changing prevalence, transmission, and outcome. A number of studies have addressed the ancestor roots of the bacteria, and the first genomewide analysis of bacterial strains suggests that its coexistence with humans is more ancient than previously thought. As opposed to the generally declining prevalence of H. pylori (including China and Japan), in Sweden, the prevalence of atrophic gastritis in the young population has risen. The prevalence of the infection remains high in the indigenous populations of the Arctic regions, and reinfection rates are high. A high prevalence is permanently found in the Siberian regions of Russia as well. Several studies, some of which used multiplex serology, addressed prevalence of and risks associated with various H. pylori serotypes, thereby enabling more precise risk assessment. Transmission of H. pylori was discussed, specifically fecal-oral transmission and the use of well-water and other unpurified water. Finally, the long-term course of H. pylori infection was considered, with an estimated 89% of noncardia gastric cancer cases being attributable to the infection.

  20. Epidemiology of neurocysticercosis in Brazil. (United States)

    Agapejev, S


    A revision of literature was done with the objective of tracing an epidemiologic profile of neurocysticercosis (NCC) in Brazil. The prevalence was 0.12-9% in autopsies. The frequency was 0.03-7.5% in clinical series and 0.68-5.2% in seroepidemiological studies. The disease corresponds to 0.08-2.5% of admissions to general hospitals. Patient origin was rural in 30-63% of cases. The most involved age range (64-100%) was 11 to 60 years, with a predominance (22-67%) between 21 and 40 years. The male sex was the most affected (51-80%). In the severe forms there was a predominance of urban origin (53-62%) and of the female sex (53-75%). The period of hospitalization ranges from 1 to 254 days and 33 to 50% of patients suffer 1.7 +/- 1.4 admissions. The clinical picture was variable, with a predominance of epileptic syndrome (22-92%) and intracranial hypertension (19-89%). Psychiatric manifestations were associated in 9-23% of patients. Lethality was 0.29% in terms of all diseases in general and 4.8-25.9% in terms of neurologic diseases. The asymptomatic form was detected in 6% of patients in clinical series and in 48.5% of case from autopsies. The racemose form and ventricular localization also was observed as asymptomatic form. Among the patients with cutaneous cysticercosis 65% of them showed neurologic manifestations.

  1. Epidemiology of Ciguatera in Florida. (United States)

    Radke, Elizabeth G; Reich, Andrew; Morris, John Glenn


    Ciguatera is the most commonly reported marine food-borne illness worldwide. Because there is a biological plausibility that ciguatera may be impacted by long-term climate variability and Florida is on the northern border of the geographic distribution of ciguatera, it is important to update our understanding of its epidemiology in Florida. We performed an analysis of 291 reports in Florida from 2000 to 2011 and an e-mail survey of 5,352 recreational fishers to estimate incidence and underreporting and identify high risk demographic groups, fish types, and catch locations. Incidence was 5.6 per 100,000 adjusted for underreporting. Hispanics had the highest incidence rate (relative risk [RR] = 3.4) and were more likely to eat barracuda than non-Hispanics. The most common catch locations for ciguatera-causing fish were the Bahamas and Florida Keys. Cases caused by fish from northern Florida were infrequent. These results indicate that ciguatera incidence is higher than estimated from public health reports alone. There is little evidence that incidence or geographic range has increased because of increased seawater temperatures since earlier studies.

  2. Epidemiology of Helicobacter pylori infection. (United States)

    Eusebi, Leonardo H; Zagari, Rocco M; Bazzoli, Franco


    Medline and PubMed databases were searched on epidemiology of Helicobacter pylori for the period of April 2013-March 2014. Several studies have shown that the prevalence of H. pylori is still high in most countries. In north European and North American populations, about one-third of adults are still infected, whereas in south and east Europe, South America, and Asia, the prevalence of H. pylori is often higher than 50%. H. pylori remains highly prevalent in immigrants coming from countries with high prevalence of H. pylori. However, the lower prevalence of infection in the younger generations suggests a further decline of H. pylori prevalence in the coming decades. Low socioeconomic conditions in childhood are confirmed to be the most important risk factors for H. pylori infection. Although the way the infection is transmitted is still unclear, interpersonal transmission appears to be the main route. Finally, H. pylori recurrence after successful eradication can still occur, but seems to be an infrequent event.

  3. Comprehensive Epidemiologic Data Resource (CEDR) (Poster)

    Energy Technology Data Exchange (ETDEWEB)

    Oak Ridge Institute for Science and Education (ORISE)


    This poster introduces the Comprehensive Epidemiologic Data Resource (CEDR), an electronic database with demographic, health outcome, and exposure information for over a million DOE nuclear plant and laboratory workers.

  4. 16 CFR 1000.26 - Directorate for Epidemiology. (United States)


    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Directorate for Epidemiology. 1000.26... AND FUNCTIONS § 1000.26 Directorate for Epidemiology. The Directorate for Epidemiology, managed by the Associate Executive Director for Epidemiology, is responsible for the collection and analysis of data...

  5. Gastric cancer - clinical and epidemiological aspects. (United States)

    Venerito, Marino; Link, Alexander; Rokkas, Theodoros; Malfertheiner, Peter


    Gastric cancer (GC) ranks fifth for cancer incidence and second for cancer deaths. Epidemiological data showed that survivors of Hodgkin's lymphoma and patients with pernicious anemia etiologically linked to autoimmune gastritis are at increased risk of GC. Screening of patients with autoimmune thyroid disease by means of pepsinogen (PG) I and PG I/II detected autoimmune gastritis with oxyntic gastric atrophy in one of four patients and may be recommended for GC prevention purposes. The International Agency for Research on Cancer reported a positive association between consumption of processed meet and increased GC risk. A new GC risk prediction model based on biological markers, age, gender, smoking status, family history of GC, and consumption of highly salted food showed good predictive performance, and might prompt individuals to modify their lifestyle habits, attend regular check-up visits or participate in screening programs. A novel GC classification based on gene expression of primary resected cancers correlated with clinicopathological features. Noncoding RNA for GC screening remains the focus of multiple studies. Patients with early GC undergoing endoscopic resection are more likely to develop metachronous lesions than patients undergoing surgery and endoscopic surveillance is warranted in this special cohort. The addition of gastrectomy to chemotherapy did not improve survival of patients with advanced GC and a single noncurable factor. Apatinib, a novel oral vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor, improved the median overall survival of patients with advanced GC and progressive disease after two or more lines of prior chemotherapy of nearly 3 months.

  6. Epidemiology of small intestinal atresia in Europe

    DEFF Research Database (Denmark)

    Best, Kate E; Tennant, Peter W G; Addor, Marie-Claude;


    The epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe.......The epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe....

  7. Maritim epidemiologi på Supercourse

    DEFF Research Database (Denmark)

    Jensen, Olaf


    Maritim epidemiologi er nu kommet med i samlingen af undervisningsmidler på ”Supercourse”. Der er oprettet en særlig mappe med Maritime Epidemiology og alle der har gode bidrag inden for området opfordres hermed til at publicere her. Supercourse er en samling af foredrag beregnet til at være en r...... of Pittsburgh af bla. Ronald LaPorte, Faina Linkov, Mita Lovalekar og Eugene Shubnikov. God fornøjelse Olaf Jensen...

  8. Yersinia enterocolitica: Epidemiological Studies and Outbreaks

    Directory of Open Access Journals (Sweden)

    Atiqur Rahman


    Full Text Available Yersinia enterocolitica is the most common bacteriological cause of gastrointestinal disease in many developed and developing countries. Although contaminated food is the main source of human infection due to Y. enterocolitica, animal reservoir and contaminated environment are also considered as other possible infection sources for human in epidemiological studies. Molecular based epidemiological studies are found to be more efficient in investigating the occurrence of human pathogenic Y. enterocolitica in natural samples, in addition to conventional culture based studies.

  9. How to make epidemiological training infectious. (United States)

    Bellan, Steve E; Pulliam, Juliet R C; Scott, James C; Dushoff, Jonathan


    Modern infectious disease epidemiology builds on two independently developed fields: classical epidemiology and dynamical epidemiology. Over the past decade, integration of the two fields has increased in research practice, but training options within the fields remain distinct with few opportunities for integration in the classroom. The annual Clinic on the Meaningful Modeling of Epidemiological Data (MMED) at the African Institute for Mathematical Sciences has begun to address this gap. MMED offers participants exposure to a broad range of concepts and techniques from both epidemiological traditions. During MMED 2010 we developed a pedagogical approach that bridges the traditional distinction between classical and dynamical epidemiology and can be used at multiple educational levels, from high school to graduate level courses. The approach is hands-on, consisting of a real-time simulation of a stochastic outbreak in course participants, including realistic data reporting, followed by a variety of mathematical and statistical analyses, stemming from both epidemiological traditions. During the exercise, dynamical epidemiologists developed empirical skills such as study design and learned concepts of bias while classical epidemiologists were trained in systems thinking and began to understand epidemics as dynamic nonlinear processes. We believe this type of integrated educational tool will prove extremely valuable in the training of future infectious disease epidemiologists. We also believe that such interdisciplinary training will be critical for local capacity building in analytical epidemiology as Africa continues to produce new cohorts of well-trained mathematicians, statisticians, and scientists. And because the lessons draw on skills and concepts from many fields in biology--from pathogen biology, evolutionary dynamics of host--pathogen interactions, and the ecology of infectious disease to bioinformatics, computational biology, and statistics--this exercise

  10. How to make epidemiological training infectious.

    Directory of Open Access Journals (Sweden)

    Steve E Bellan

    Full Text Available Modern infectious disease epidemiology builds on two independently developed fields: classical epidemiology and dynamical epidemiology. Over the past decade, integration of the two fields has increased in research practice, but training options within the fields remain distinct with few opportunities for integration in the classroom. The annual Clinic on the Meaningful Modeling of Epidemiological Data (MMED at the African Institute for Mathematical Sciences has begun to address this gap. MMED offers participants exposure to a broad range of concepts and techniques from both epidemiological traditions. During MMED 2010 we developed a pedagogical approach that bridges the traditional distinction between classical and dynamical epidemiology and can be used at multiple educational levels, from high school to graduate level courses. The approach is hands-on, consisting of a real-time simulation of a stochastic outbreak in course participants, including realistic data reporting, followed by a variety of mathematical and statistical analyses, stemming from both epidemiological traditions. During the exercise, dynamical epidemiologists developed empirical skills such as study design and learned concepts of bias while classical epidemiologists were trained in systems thinking and began to understand epidemics as dynamic nonlinear processes. We believe this type of integrated educational tool will prove extremely valuable in the training of future infectious disease epidemiologists. We also believe that such interdisciplinary training will be critical for local capacity building in analytical epidemiology as Africa continues to produce new cohorts of well-trained mathematicians, statisticians, and scientists. And because the lessons draw on skills and concepts from many fields in biology--from pathogen biology, evolutionary dynamics of host--pathogen interactions, and the ecology of infectious disease to bioinformatics, computational biology, and

  11. Vygotsky in applied neuropsychology

    Directory of Open Access Journals (Sweden)

    Glozman J. M.


    Full Text Available The aims of this paper are: 1 to show the role of clinical experience for the theoretical contributions of L.S. Vygotsky, and 2 to analyze the development of these theories in contemporary applied neuropsychology. An analysis of disturbances of mental functioning is impossible without a systemic approach to the evidence observed. Therefore, medical psychology is fundamental for forming a systemic approach to psychology. The assessment of neurological patients at the neurological hospital of Moscow University permitted L.S. Vygotsky to create, in collaboration with A.R. Luria, the theory of systemic dynamic localization of higher mental functions and their relationship to cultural conditions. In his studies of patients with Parkinson’s disease, Vygotsky also set out 3 steps of systemic development: interpsychological, then extrapsychological, then intrapsychological. L.S. Vygotsky and A.R. Luria in the late 1920s created a program to compensate for the motor subcortical disturbances in Parkinson’s disease (PD through a cortical (visual mediation of movements. We propose to distinguish the objective mediating factors — like teaching techniques and modalities — from subjective mediating factors, like the individual’s internal representation of his/her own disease. The cultural-historical approach in contemporary neuropsychology forces neuropsychologists to re-analyze and re-interpret the classic neuropsychological syndromes; to develop new assessment procedures more in accordance with the patient’s conditions of life; and to reconsider the concept of the social brain as a social and cultural determinant and regulator of brain functioning. L.S. Vygotsky and A.R. Luria proved that a defect interferes with a child’s appropriation of his/her culture, but cultural means can help the child overcome the defect. In this way, the cultural-historical approach became, and still is, a methodological basis for remedial education.

  12. Geohelminth contamination of public areas and epidemiological risk factors in Curitiba, Brazil

    Directory of Open Access Journals (Sweden)

    Lew Kan Sprenger

    Full Text Available This study aimed to investigate the frequency of geohelminthic contamination of public parks and squares in Curitiba, state of Paraná, Brazil, between August and December 2010. A total of 345 samples were collected from 69 sandboxes in different areas and were tested using the Faust, Lutz and Baermann parasitological techniques. Potential risk factors associated with soil contamination were also analyzed. A total of 36% of the samples (124/345 were positive for helminths and 65.2% of the areas (45/69 were classified as contaminated in one or more samples. The most commonly identified parasite eggs were Ancylostoma sp. (14.5%; 50/345; followed by Toxocara sp. (9.6%; 33/345 and the Strongyloidea superfamily (excluding hookworms (2.3%; 8/345. The analysis on the epidemiological risk factors indicated that the presence of dogs and feces in the sandboxes increased the chances of contamination of the site. Use of fences had a protective positive impact that reduced soil contamination. Health education programs should be applied within the community to minimize the risk of human contact with dogs' feces. Use of fencing in these areas is highly recommended to prevent or reduce the users' contact with animal excrement.

  13. Australia and New Zealand Applied Linguistics (ANZAL): Taking Stock (United States)

    Kleinsasser, Robert C.


    This paper reviews some emerging trends in applied linguistics in both Australia and New Zealand. It sketches the current scene of (selected) postgraduate applied linguistics programs in higher education and considers how various university programs define applied linguistics through the classes (titles) they have postgraduate students complete to…

  14. The Cybernetic Writing Program. (United States)

    Lowe, Kelly Fisher

    This paper looks at the role of a Writing Program Administrator, and applies the idea of a cybernetic system to the administration of the program. In this cybernetic model, the Writing Program Administrator (WPA) works as both a problem solver and problem causer, with the responsibility of keeping the program in proper balance. A cybernetic…

  15. Malaria Four-year Epidemiological Trends in Sistan and Baluchistan Province, Iran (United States)

    Norouzinezhad, Faezeh; Ghaffari, Fatemeh; Raeisi, Ahmad; Norouzinejad, Abbas; Kaveh, Farzad


    Introduction Malaria is one of the foremost public health concerns in Iran, where more than 90% of malaria cases are reported in the southern and south-eastern areas of the country. The aim of this study was to assess the epidemiological trends of malaria over a four-year period in in the Sistan and Baluchistan province in south east of Iran. Methods This descriptive epidemiological study examined malaria trends in Sistan and Baluchistan province from 2011 to 2014. The study used data collected in accordance with the Iranian Ministry of Health’s malaria control and elimination protocol. This protocol has digitized the data reporting system for malaria, and all information were sent online to the Center of Disease Control in the Ministry of Health. In this manner, information on malaria cases in Sistan and Baluchistan were made available for the researchers to analyze. Descriptive and comparative analyses were conducted using the SPSS version 13. Results Annual incidence rates reported in 2011, 2012, 2013, and 2014 showed the prevalence of 89.9, 43.9, 38.3 and 36.6 (per 100,000 persons), respectively. Across all 4 years, the highest numbers of cases were found in persons 16–25 years old and among males. Most of the infected individuals were villagers and workers. In total, 64.8% of patients were Iranian and 29.5% were Pakistani. The highest number of cases was diagnosed in the cities of Sarbaz and Chabahar, with 1,742 and 1,707 cases, respectively. The results showed that over the last 4 years, 50.8% of cases have entered into Iran from foreign countries. The majority of cases involved parasites in the trophozoite stage of the life cycle. In terms of surveillance, passive care was reported in the majority of cases, and vivax malaria had the highest prevalence in comparison with other types. Conclusion The findings are showing that the care, control and treatment system applied to Sistan and Baluchistan province has had a positive effect on decreasing the

  16. Cannabis Epidemiology: A Selective Review (United States)

    Anthony, James C.; Lopez-Quintero, Catalina; Alshaarawy, Omayma


    Background Globally, the most widely used set of compounds among the internationally regulated drugs is cannabis. Objective To review evidence from epidemiological research on cannabis, organized in relation to this field’s five main rubrics: quantity, location, causes, mechanisms, and prevention/control. Method The review covers a selection of evidence from standardized population surveys, official statistics, and governmental reports, as well as published articles and books identified via MEDLINE, Web of Science, and Google Scholar as of July 2016. Results In relation to quantity, an estimated 3% to 5% of the world population is thought to have tried a cannabis product, with at least one fairly recent use, mainly extra-medical and outside boundaries of prescribed use. Among cannabis users in the United States, roughly one in 7–8 has engaged in medical marijuana use. In relation to location, prevalence proportions reveal important variations across countries and between subgroups within countries. Regarding causes and mechanisms of starting to use cannabis, there is no compelling integrative and replicable conceptual model or theoretical formulation. Most studies of mechanisms have focused upon a ‘gateway sequence’ and person-to-person diffusion, with some recent work on disability-adjusted life years. A brief review of cannabis use consequences, as well as prevention and control strategies is also provided. Conclusion At present, we know much about the frequency and occurrence of cannabis use, with too little replicable definitive evidence with respect to the other main rubrics. Given a changing regulatory environment for cannabis products, new institutions such as an independent International Cannabis Products Safety Commission may be required to produce evidence required to weigh benefits versus costs. It is not clear that government sponsored research will be sufficient to meet consumer demand for balanced points of view and truly definitive evidence

  17. Epidemiology of Bluetongue in India. (United States)

    Rao, P P; Hegde, N R; Reddy, Y N; Krishnajyothi, Y; Reddy, Y V; Susmitha, B; Gollapalli, S R; Putty, K; Reddy, G H


    Bluetongue (BT) is an insectborne endemic disease in India. Although infections are observed in domestic and wild ruminants, the clinical disease and mortality are observed only in sheep, especially in the southern states of the country. The difference in disease patterns in different parts of the country could be due to varied climatic conditions, sheep population density and susceptibility of the sheep breeds to BT. Over the five decades after the first report of BT in 1964, most of the known serotypes of bluetongue virus (BTV) have been reported from India either by virus isolation or by detection of serotype-specific antibodies. There have been no structured longitudinal studies to identify the circulating serotypes throughout the country. At least ten serotypes were isolated between 1967 and 2000 (BTV-1-4, 6, 9, 16-18, 23). Since 2001, the All-India Network Programme on Bluetongue and other laboratories have isolated eight different serotypes (BTV-1-3, 9, 10, 12, 16, 21). Genetic analysis of these viruses has revealed that some of them vary substantially from reference viruses, and some show high sequence identity with modified live virus vaccines used in different parts of the world. These observations have highlighted the need to develop diagnostic capabilities, especially as BT outbreaks are still declared based on clinical signs. Although virus isolation and serotyping are the gold standards, rapid methods based on the detection of viral nucleic acid may be more suitable for India. The epidemiological investigations also have implications for vaccine design. Although only a handful serotypes may be involved in causing outbreaks every year, the combination of serotypes may change from year to year. For effective control of BT in India, it may be pertinent to introduce sentinel and vector traps systems for identification of the circulating serotypes and to evaluate herd immunity against different serotypes, so that relevant strains can be included in vaccine

  18. Varicella in Europe-A review of the epidemiology and experience with vaccination

    DEFF Research Database (Denmark)

    Helmuth, Ida Glode; Poulsen, Anja; Suppli, Camilla Hiul


    There is no consensus as regards the European varicella immunisation policy; some countries have introduced varicella vaccination in their routine childhood immunisation programs whereas others have decided against or are debating. With the aim of providing an overview of the epidemiology...... adults. Hospitalisation due to varicella is not common, but complications and hospitalisation mainly affect previously healthy children, which underlines the importance of not dismissing varicella as a disease of little importance. The experience with universal vaccination in Europe shows...... of varicella in Europe and addressing the different strategies and the experiences so far, we performed a review of epidemiological studies done in Europe from 2004 to 2014. Varicella is mainly a disease of childhood, but sero-epidemiological studies show regional differences in the proportion of susceptible...

  19. [Sanitary and epidemiological supply for the Russian Army during the First World War (1914-1918)]. (United States)

    gorelova, L E; Loktev, A E


    At the beginning of the First World War the most typical diseases in the Russian Army were typhoid, typhus, diphtheria, cholera, smallpox and other infectious diseases. At the beginning of the First World War the level of infectious morbidity was significantly low, but further increased and pandemic risk arose. Servicemen were mostly ill with typhus, relapsing fever, flux, cholera, smallpox and typhoid. The highest mortality rate was registered in patients with cholera, typhus and typhoid. According the prewar deployment program of the Russian Army anti-epidemiologic facilities were established. By the end of war were established 110 sanitary-and-hygienic and 90 disinfection units. However, organization of anti-epidemiologic security was unsatisfactory. Due to lack of specialists and equipment anti-epidemiologic facilities of units were under strength. Commanders of sanitary units and sanitary service had not enough resources for operational service in the Forces and facilities of rear area.

  20. A comprehensive review of the epidemiology and disease burden of Influenza B in 9 European countries. (United States)

    Tafalla, Monica; Buijssen, Marleen; Geets, Régine; Vonk Noordegraaf-Schouten, Marije


    This review was undertaken to consolidate information on the epidemiology and burden of influenza B, as well as the circulation patterns of influenza B lineage in 9 European countries. Following a comprehensive search of peer-reviewed and gray literature sources, we found that published data on influenza B epidemiology and burden are scarce. Surveillance data show frequent co-circulation of both influenza B lineages during influenza seasons, but little is known about its impact, especially in adults and the clinical burden of influenza B remains unknown. Mismatch between the circulating influenza B lineage and vaccine recommendations has been seen in at least one influenza season in every country. Such observations could impact the effectiveness of seasonal influenza vaccination programs using trivalent vaccines, which contain only one influenza B lineage (B/Yamagata or B/Victoria) and highlight the need for local studies to better understand the epidemiology and burden of influenza B in these countries.

  1. Cluster detection methods applied to the Upper Cape Cod cancer data

    Directory of Open Access Journals (Sweden)

    Ozonoff David


    Full Text Available Abstract Background A variety of statistical methods have been suggested to assess the degree and/or the location of spatial clustering of disease cases. However, there is relatively little in the literature devoted to comparison and critique of different methods. Most of the available comparative studies rely on simulated data rather than real data sets. Methods We have chosen three methods currently used for examining spatial disease patterns: the M-statistic of Bonetti and Pagano; the Generalized Additive Model (GAM method as applied by Webster; and Kulldorff's spatial scan statistic. We apply these statistics to analyze breast cancer data from the Upper Cape Cancer Incidence Study using three different latency assumptions. Results The three different latency assumptions produced three different spatial patterns of cases and controls. For 20 year latency, all three methods generally concur. However, for 15 year latency and no latency assumptions, the methods produce different results when testing for global clustering. Conclusion The comparative analyses of real data sets by different statistical methods provides insight into directions for further research. We suggest a research program designed around examining real data sets to guide focused investigation of relevant features using simulated data, for the purpose of understanding how to interpret statistical methods applied to epidemiological data with a spatial component.

  2. The epidemiology of anxiety disorders in the Arab world: a review. (United States)

    Tanios, Christine Y; Abou-Saleh, Mohammad T; Karam, Aimée N; Salamoun, Mariana M; Mneimneh, Zeina N; Karam, Elie G


    Epidemiological studies are quite rare in the Arab world. The Institute for Development Research Advocacy and Applied Care (IDRAAC) has conducted a systematic review of all epidemiologic research on anxiety disorders in the Arab world up to 2006. Specific keywords were used in the search for affective disorders, namely anxiety, generalized anxiety disorder, GAD, panic, separation anxiety disorder, SAD, overanxious disorder, OAD, phobia, fear, post-traumatic stress disorder, PTSD, obsessive compulsive disorder (OCD), obsessive compulsive symptom (OCS), obsession, compulsion, obsessive, compulsive. All results were screened and categorized. Epidemiological data on prevalence, gender differences, age of onset, comorbidity, risk factors and treatment of anxiety disorders in the Arab world were found in clinical and community samples. There is an evident need for national data on anxiety disorders in the Arab world in order to identify the magnitude of these diseases and their burden on the individual and community.

  3. Updates on cardiovascular comorbidities associated with psoriatic diseases: epidemiology and mechanisms. (United States)

    Yim, Kaitlyn M; Armstrong, April W


    Psoriasis and psoriatic arthritis are associated with a significantly increased risk of cardiovascular risk factors and major adverse cardiovascular events (MACE). Active research is ongoing to elucidate this relationship between psoriatic diseases and cardiovascular comorbidities, as well as their shared pathogenic mechanisms. This review focuses on (1) the epidemiologic association between psoriasis and cardiovascular risk factors, (2) the epidemiologic association between psoriasis and MACE, (3) the epidemiologic association between psoriatic arthritis, cardiovascular risk factors, and MACE, and (4) proposed mechanisms for the contribution of psoriatic diseases to cardiovascular diseases. The proposed mechanisms for shared pathogenesis between psoriatic diseases and cardiovascular diseases are inflammation, insulin resistance, dyslipidemia, angiogenesis, oxidative stress, and endothelial dysfunction. There is complex interplay and overlap among these mechanisms and their contributions to shared pathogenesis. Future translational research is necessary to elucidate the link between psoriatic diseases and cardiovascular diseases. Such findings may be applied clinically to improve the lives of psoriasis patients.

  4. Molecular Epidemiology of Fonsecaea Species

    NARCIS (Netherlands)

    Najafzadeh, M.J.; Sun, J.; Vicente, V.A.; Klaassen, C.H.W.; Bonifaz, A.; Gerrits van den Ende, A.H.G.; Menken, S.B.J.; de Hoog, G.S.


    To assess population diversities among 81 strains of fungi in the genus Fonsecaea that had been identified down to species level, we applied amplified fragment-length polymorphism (AFLP) technology and sequenced the internal transcribed spacer regions and the partial cell division cycle, β-tubulin,

  5. Molecular epidemiology of Mycobacterium tuberculosis complex in Brussels, 2010–2013 (United States)

    Vluggen, Christelle; Soetaert, Karine; Groenen, Guido; Wanlin, Maryse; Spitaels, Martine; Arrazola de Oñate, Wouter; Fauville-Dufaux, Maryse; Saegerman, Claude


    The tuberculosis (TB) incidence rate in Brussels-Capital Region is 3-fold higher than in Belgium as a whole. Eight years after the realization of initial prospective population-based molecular epidemiology investigations in this Region, a similar study over the period 2010–2013 was conducted. TB strains isolated from 945 patients were submitted to genotyping by standardized 24-locus-MIRU-VNTR typing and spoligotyping. The phylogenetic analysis showed that the LAM (16.7%) and Haarlem (15.7%) branches are the two most prevalent TB lineages circulating in Brussels. Analysis of the MDR subgroup showed an association with Beijing strains (39.9%) and patients native of Eastern Europe (40.7%). Genotyping detected 113 clusters involving 321 patients, giving a recent transmission index of 22.9%. Molecular-guided epidemiological investigations and routine surveillance activities revealed family transmission or social contact for patients distributed over 34 clusters. Most of the patients were foreign-born (75.7%). However, cluster analysis revealed only limited trans-national transmission. Comparison with the previous study shows a stable epidemiological situation except for the mean age difference between Belgian-born and foreign-born patients which has disappeared. This study confirms that molecular epidemiology has become an important determinant for TB control programs. However, sufficient financial means need to be available to perform all required epidemiological investigations. PMID:28222189

  6. Gallbladder cancer: epidemiology and outcome

    Directory of Open Access Journals (Sweden)

    Hundal R


    Full Text Available Rajveer Hundal, Eldon A Shaffer Division of Gastroenterology, Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada Abstract: Gallbladder cancer, though generally considered rare, is the most common malignancy of the biliary tract, accounting for 80%-95% of biliary tract cancers. An early diagnosis is essential as this malignancy progresses silently with a late diagnosis, often proving fatal. Its carcinogenesis follows a progression through a metaplasia-dysplasia-carcinoma sequence. This comprehensive review focuses on and explores the risks, management, and outcomes for primary gallbladder carcinoma. Epidemiological studies have identified striking geographic and ethnic disparities – inordinately high occurrence in American Indians, elevated in Southeast Asia, yet quite low elsewhere in the Americas and the world. Age, female sex, congenital biliary tract anomalies, and a genetic predisposition represent important risk factors that are immutable. Environmental triggers play a critical role in eliciting cancer developing in the gallbladder, best exemplified by cholelithiasis and chronic inflammation from biliary tract and parasitic infections. Mortality rates closely follow incidence; those countries with the highest prevalence of gallstones experience the greatest mortality from gallbladder cancer. Vague symptoms often delay the diagnosis of gallbladder cancer, contributing to its overall progression and poor outcome. Surgery represents the only potential for cure. Some individuals are fortunate to be incidentally found to have gallbladder cancer at the time of cholecystectomy being performed for cholelithiasis. Such an early diagnosis is imperative as a late presentation connotes advanced staging, nodal involvement, and possible recurrence following attempted resection. Overall mean survival is a mere 6 months, while 5-year survival rate is only 5%. The dismal prognosis, in part, relates to the

  7. Epidemiology of ANCA associated vasculitis

    Directory of Open Access Journals (Sweden)

    Wenche Koldingsnes


    Full Text Available ANCA associated vasculitis (AAV comprises three syndromes with systemic vasculitis (Wegener’s granulomatosis (WG, Churg Strauss syndrome (CSS and icroscopic polyangiitis (MPA, which all involve small and medium sized vessels and are associated with antibodies against cytoplasmatic antibodies in neutrophils (ANCA. Polyarteritis nodosa (PAN is included in this review as it also affects medium sized vessels, and has many clinical findings in common with the AAV.Since the recognition of ANCA, increasing data have become available on the epidemiology of these vasculitidis. WG constitutes half of the AAV and its prevalence has increased from 30/million in the late 1980’s in the USA to 160/million in this century in northern Europe. The prevalence for the whole group of primary systemic vasculitides is now 300/million in Sweden. The annual incidence of WG increased from 6.0/million to 14/million during the 1990’s in Tromsø, but it is unknown if this is a true increase or the result of an increased awareness of the diagnosis. For the whole group of AAV, the annual incidence in most more recent studies is relatively constant over time and by geographical location, ranging from 13 to 21/million. Nonetheless there are interesting differences in the prevalence of specific vasculitis between different geographical areas, as well as for sub specificities of ANCA.There seems to be a South-North gradient for WG and PR3-ANCA with high figures reported from northern Europe and southern New Zealand. In European studies WG is 90% PR3-ANCA positive. MPA which is predominantly MPO-ANCA associated are more frequent in the Mediterranean countries and also has an increasing gradient towards east-Asia, as almost all AAV in China and Japan are diagnosed as MPA, predominantly MPO-ANCA positive.There are also some ethnic and gender differences. WG is most prevalent among Caucasians in the USA and in people with European ancestors in Paris and in New Zealand, less

  8. [Scientific, practical and educational aspects of clinical epidemiology]. (United States)

    Briko, N I


    This article defines clinical epidemiology and describes its goal and objectives. The author claims that clinical epidemiology is a section of epidemiology which underlies the development of evidence-based standards for diagnostics, treatment and prevention and helps to select the appropriate algorithm for each clinical case. The study provides a comprehensive overview of the relationship between clinical epidemiology and evidence-based medicine. Epidemiological research is shown to be methodological basis of clinical epidemiology and evidence-based medicine with randomized controlled trials being the "gold standard" for obtaining reliable data. The key stages in the history of clinical epidemiology are discussed and further development of clinical epidemiology and the integration of courses on clinical epidemiology in education is outlined for progress in medical research and health care practice.

  9. An argument for a consequentialist epidemiology. (United States)

    Galea, Sandro


    Epidemiology is the study of the causes and distributions of diseases in human populations so that we may identify ways to prevent and control disease. Although this definition broadly serves us well, I suggest that in recent decades, our discipline's robust interest in identifying causes has come at the expense of a more rigorous engagement with the second part of our vision for ourselves-the intent for us to intervene-and that this approach threatens to diminish our field's relevance. I argue here for a consequentialist epidemiology, a formalization and recalibration of the philosophical foundations of our discipline. I discuss how epidemiology is, at its core, more comfortably a consequentialist, as opposed to a deontological, discipline. A more consequentialist approach to epidemiology has several implications. It clarifies our research priorities, offers a perspective on the place of novel epidemiologic approaches and a metric to evaluate the utility of new methods, elevates the importance of global health and considerations about equity to the discipline, brings into sharp focus our engagement in implementation and translational science, and has implications for how we teach our students. I intend this article to be a provocation that can help clarify our disciplinary intentions.

  10. Perspectives on Applied Ethics



    Applied ethics is a growing, interdisciplinary field dealing with ethical problems in different areas of society. It includes for instance social and political ethics, computer ethics, medical ethics, bioethics, envi-ronmental ethics, business ethics, and it also relates to different forms of professional ethics. From the perspective of ethics, applied ethics is a specialisation in one area of ethics. From the perspective of social practice applying eth-ics is to focus on ethical aspects and ...

  11. Advances in Applied Mechanics



    Advances in Applied Mechanics draws together recent significant advances in various topics in applied mechanics. Published since 1948, Advances in Applied Mechanics aims to provide authoritative review articles on topics in the mechanical sciences, primarily of interest to scientists and engineers working in the various branches of mechanics, but also of interest to the many who use the results of investigations in mechanics in various application areas, such as aerospace, chemical, civil, en...

  12. Epidemiology, etiology and study of clinical findings of headache

    Directory of Open Access Journals (Sweden)

    Ghaffarpoor M


    clinical practice, treating, teaching, clinical and epidemiological research is very useful and must also be applied for Iranian patients.

  13. Epidemiological surveillance of lymphocryptovirus infection in wild bonobos

    Directory of Open Access Journals (Sweden)

    Tomoyuki Yoshida


    Full Text Available Lymphocryptovirus (LCV is one of the major gena in the herpesvirus family and is widely disseminated among primates. LCVs of human and rhesus macaques are shown to be causative agents of a number of malignant diseases including lymphoma and carcinoma. Bonobos (Pan paniscus are highly endangered and the least studied species of the great apes. Considering the potential pathogenicity of the LCV that might threaten the fate of wild bonobos, population-based epidemiological information in terms of LCV prevalence in different location of Bonobo’s habitats will help propose improved conservation strategies for the bonobos. However, such data are not available yet because it is very difficult to collect blood samples in the wild and thus virtually impossible to conduct sero-epidemiological study on the wild ape. In order to overcome this issue, we focused on evaluating anti-LCV IgA in the feces of bonobos, which are available in a noninvasive manner. Preliminary study showed that anti-LCV IgA but not IgG was efficiently and reproducibly detected in the feces of captive chimpanzees. It is noteworthy that the fecal IgA-positive individuals were seropositive for both anti-LCV IgG and IgA and that the IgA antibodies in both sera and feces were also detectable by Western blotting assay. These results indicate that the detection of fecal anti-LCV IgA is likely a reliable and feasible for epidemiological surveillance of LCV prevalence in the great apes. We then applied this method and found that 31% of wild bonobos tested were positive for anti-LCV IgA antibody in the feces. Notably, the positivity rates varied extensively among their sampled populations. In conclusion, our results in this study demonstrate that LCV is highly disseminated among wild bonobos while the prevalence is remarkably diverse in their population-dependent manner.

  14. Applied Neuroscience Laboratory Complex (United States)

    Federal Laboratory Consortium — Located at WPAFB, Ohio, the Applied Neuroscience lab researches and develops technologies to optimize Airmen individual and team performance across all AF domains....

  15. The Economic Epidemiology of Crime.


    Tomas J. Philipson; Posner, Richard A


    Economic analysis of infectious diseases emphasizes the self-correcting character of epidemics, as rising risk of infection causes potential victims to take self-protective measures. We apply the analysis to crime, showing how rational potential victims of crime will take increased self-protective measures in response to rising crime rates, causing those rates to moderate. Victim responses to crime can offset public expenditures on crime control; this implies that there may be a "natural" rat...

  16. Redis applied design patterns

    CERN Document Server

    Chinnachamy, Arun


    This book is for developers who are already proficient in programming and capable of designing systems using traditional databases, but are new to Redis. It is assumed that you understand the basics of Redis and are familiar with the various data structures. You are also expected to be proficient in one or more programming languages through which you want to use Redis.

  17. 34 CFR 350.4 - What regulations apply? (United States)


    ... (IRB) reviews research that purposefully requires inclusion of children with disabilities or... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION DISABILITY AND REHABILITATION RESEARCH PROJECTS AND CENTERS PROGRAM General § 350.4 What regulations apply? The following regulations apply to the Disability...

  18. Evidence for transgenerational metabolic programming in Drosophila



    SUMMARY Worldwide epidemiologic studies have repeatedly demonstrated an association between prenatal nutritional environment, birth weight and susceptibility to adult diseases including obesity, cardiovascular disease and type 2 diabetes. Despite advances in mammalian model systems, the molecular mechanisms underlying this phenomenon are unclear, but might involve programming mechanisms such as epigenetics. Here we describe a new system for evaluating metabolic programming mechanisms using...

  19. Association Between Cannabis and Psychosis: Epidemiologic Evidence. (United States)

    Gage, Suzanne H; Hickman, Matthew; Zammit, Stanley


    Associations between cannabis use and psychotic outcomes are consistently reported, but establishing causality from observational designs can be problematic. We review the evidence from longitudinal studies that have examined this relationship and discuss the epidemiologic evidence for and against interpreting the findings as causal. We also review the evidence identifying groups at particularly high risk of developing psychosis from using cannabis. Overall, evidence from epidemiologic studies provides strong enough evidence to warrant a public health message that cannabis use can increase the risk of psychotic disorders. However, further studies are required to determine the magnitude of this effect, to determine the effect of different strains of cannabis on risk, and to identify high-risk groups particularly susceptible to the effects of cannabis on psychosis. We also discuss complementary epidemiologic methods that can help address these questions.

  20. Epidemiology of Injury in Gaelic Handball. (United States)

    O'Connor, S; Downey, M; Moran, K


    The initial step in developing injury prevention strategies is to establish the epidemiology of injury. However there has been no published research on injury in Gaelic handball. This study describes the epidemiology of injury in 75 Gaelic handball players utilising a retrospective questionnaire. 88% of participants reported one or more injuries. Injuries to the upper limb were prevalent (52.9%), followed by the lower limb (30.3%). The shoulder (17.6%), finger (10.5%) and ankle (9.8%) were the primary sites of injury. Injuries occurred most frequently in December (9.7%), January (9.7%), February (9.7%) and November (8.7%). Injuries predominantly occurred during games (82.4%). Injuries were primarily severe (54.7%), with 14.6% of participants admitted to hospital due to injury. Given that this is the only study on Gaelic handball to date, prospective epidemiological studies and further research on injury prevention strategies are necessary.