WorldWideScience

Sample records for applications therapeutiques roles

  1. Recours therapeutique en pediatrie: place de l'automedication chez ...

    African Journals Online (AJOL)

    L'itineraire therapeutique fait reference aux parcours utilises par les individus pour !'obtention de soins en developpant des strategies les mettant en relation avec divers lieux de traitements. L' objectif de notre travail etait d'etudier les itineraires therapeutiques des enfants rei(US au CHUP CDG. 11 s'est agi d'une etude ...

  2. CERN's role in medical applications

    CERN Multimedia

    Antonella Del Rosso

    2014-01-01

    Last week, CERN hosted the first meeting of the International Strategy Committee for medical applications. This Committee will help CERN establish its roadmap in the field of research and development activities for medical applications. Here the CERN Bulletin speaks with the Chair of the Committee as he shares his expectations and his vision.   Dr Michael Baumann is the Director of the Radiation Oncology department at the Carl Gustav Carus University Hospital in Dresden and of the Institute for Radiooncology of the Helmholtz-Zentrum Dresden-Rossendorf (Germany). He has recently been appointed Chair of CERN’s International Strategy Committee for medical applications – the team of experts who will advise the CERN Medical Applications Study Group led by Steve Myers. “CERN has a tremendous record in physics and basic research,” says Baumann. “I think that it has a very important role in steering some of the R&D that cannot be done at universities ...

  3. Radioinduced intestinal fibrosis: from molecular mechanisms to therapy applications. Contribution of the TGF--{beta}1, of the CTGF and of the transduction pathway of the Rho/ROCK signal; La fibrose intestinale radio-induite: des mecanismes moleculaires aux applications therapeutiques. Roles du TGF-{beta}1, du CTGF et de la voie de transduction du signal Rho/ROCK

    Energy Technology Data Exchange (ETDEWEB)

    Haydont, V

    2006-12-15

    Delayed radiation enteritis is an intestinal fibrosis induced by accidental or therapeutic radiation for pelvic and abdominal cancer treatments. Studies of molecular mechanisms involved in the development and maintenance of fibrosis have showed the respective contribution of CTGF, low TGF-{beta}1 concentrations and Rho/ROCK pathway. Thus, based on the relationship between CTGF, TGF-{beta}1 and Rho pathway, 2 therapeutics strategies have been develop. First, a pravastatin curative gift leads to a fibro-lysis involving an inhibition of Rho and in cascade a reduction of CTGF expression and extracellular matrix deposition. The data suggest that reversal of established radiation fibrosis in the gut is possible. Second, a pravastatin prophylactic gift prevents the installation of a chronic fibrosis but does not protect the tumor. On the base of these results, the radiation therapy department of the Institut Gustave Roussy will soon initiate 2 clinical trials. (author)

  4. Role of dosimetry in radiation processing applications

    International Nuclear Information System (INIS)

    Mehta, Kishor

    2001-01-01

    Today, radiation processing is a growing technology offering potential technological advantages as well as enhanced safety and economy. It is expanding on two fronts: the variety of applications is exploding as well as the sources of radiation. And with that comes the necessary advances in dosimetry. However, the success of the technology still depends on the assertion that the irradiated products are reliable and safe, whether they are health care products or cables and wires. And this is best assured through quality assurance programmes. The key element in QA in radiation processing is a well-characterised, reliable dosimetry that is traceable to the international measurement system. Traceability is the foundation for international acceptance of the irradiated products; and with international trade of irradiated products on the rise, it becomes absolutely critical. It is thus vital that the industry recognises this pivotal position of good dosimetry and the role a national standards laboratory plays in that connection. (author)

  5. The role of geotextiles in geosynthetic applications

    CSIR Research Space (South Africa)

    Anandjiwala, RD

    2013-11-01

    Full Text Available , is required. Needlepunched nonwoven geotextiles are extensively used in civil engineering applications, including road and railway construction, landfills, land reclamation, sea defence, and reinforcement of clay slopes. Such applications require geotextiles...

  6. The non-conventional therapeutical indications of I 131; Les indications therapeutiques non conventionnelles de l`I 131

    Energy Technology Data Exchange (ETDEWEB)

    Delisle, M.J.; Schvartz, C.; Maes, B.; Vaudrey, C.; Pochart, J.M. [I.J.G. BP 171, 51056 Reims (France)

    1997-12-31

    In our therapeutic activity the non-conventional indications represent 5-10% relative to the indisputable indications which the hyperthyroidism in the second half of the life and the differential thyroid cancers are. In this paper our experience since 1966 is revised and confronted with the data of international literature. In the last almost 40 years we have treated 178 hyperthyroidism of which 17 were youngsters between 16 and 20 years old, 17 multi-nodular euthyroid goiters (MEG), 85 advanced cardiopathies and 8 Cordarone cardiopathies. The indications are precise: relapses after ATS or surgery in young subjects, counter-indications or surgery refusal for the MEGs and cardiologic indications. The long term surveillance was managed by an adequate code. Immediate morbidity is null. The efficiency is high in the hyperthyroidism treatment. The hypothyroidism is diagnosed and early treated. The reduction of the MEG mass is significant. An objective amelioration of the heart state was obtained (23%). The evaluation of the preventive effect of induced hyperthyroidism by Cordarone is underway. In conclusion, the enlargement of indications concerns mainly the hyperthyroidism in young subjects. In order to avoid carcinogenic risks we excluded the children under 16 years, excepting for special situations. This extension to the procreation age imposes a rigorous application of contraception and radiation protection instructions and needs a prolonged evaluation of results

  7. HTR's role in process heat applications

    International Nuclear Information System (INIS)

    Kuhr, Reiner

    2008-01-01

    Advanced high-temperature nuclear reactors create a number of new opportunities for nuclear process heat applications. These opportunities are based on the high-temperature heat available, smaller reactor sizes, and enhanced safety features that allow siting close to process plants. Major sources of value include the displacement of premium fuels and the elimination of CO 2 emissions from combustion of conventional fuels and their use to produce hydrogen. High value applications include steam production and cogeneration, steam methane reforming, and water splitting. Market entry by advanced high-temperature reactor technology is challenged by the evolution of nuclear licensing requirements in countries targeted for early applications, by the development of a customer base not familiar with nuclear technology and related issues, by convergence of oil industry and nuclear industry risk management, by development of public and government policy support, by resolution of nuclear waste and proliferation concerns, and by the development of new business entities and business models to support commercialization. New HTR designs may see a larger opportunity in process heat niche applications than in power given competition from larger advanced light water reactors. Technology development is required in many areas to enable these new applications, including the commercialization of new heat exchangers capable of operating at high temperatures and pressures, convective process reactors and suitable catalysts, water splitting system and component designs, and other process-side requirements. Key forces that will shape these markets include future fuel availability and pricing, implementation and monetization of CO 2 emission limits, and the formation of international energy and environmental policy that will support initiatives to provide the nuclear licensing frameworks and risk distribution needed to support private investment. This paper was developed based on a plenary

  8. Application Framework with Abstractions for Protocol and Agent Role

    DEFF Research Database (Denmark)

    Kristensen, Bent Bruun

    2016-01-01

    In multi-agent systems, agents interact by sending and receiving messages and the actual sequences of message form interaction structures between agents. Protocols and agents organized internally by agent roles support these interaction structures. Description and use of protocols based on agent ...... roles are supported by a simple and expressive application framework....

  9. Role Playing: Applications in Hostage and Crisis Negotiation Skills Training

    Science.gov (United States)

    Van Hasselt, Vincent B.; Romano, Stephen J.; Vecchi, Gregory M.

    2008-01-01

    Role playing has been a mainstay of behavioral assessment for decades. In recent years, however, this analogue strategy has also enjoyed widespread application in the field of law enforcement. Most notably, role-play procedures have become an integral component of assessment and training efforts in hostage and crisis negotiation, which attempts to…

  10. Metamaterial inspired electromagnetic applications role of intelligent systems

    CERN Document Server

    2017-01-01

    This book focuses on the role of soft-computing-based electromagnetic computational engines in design and optimization of a wide range of electromagnetic applications. In addition to the theoretical background of metamaterials and soft-computing techniques, the book discusses novel electromagnetic applications such as tensor analysis for invisibility cloaking, metamaterial structures for cloaking applications, broadband radar absorbers, and antennas. The book will prove to be a valuable resource for academics and professionals, as well as military researchers working in the area of metamaterials.

  11. Landsat's role in ecological applications of remote sensing.

    Science.gov (United States)

    Warren B. Cohen; Samuel N. Goward

    2004-01-01

    Remote sensing, geographic information systems, and modeling have combined to produce a virtual explosion of growth in ecological investigations and applications that are explicitly spatial and temporal. Of all remotely sensed data, those acquired by landsat sensors have played the most pivotal role in spatial and temporal scaling. Modern terrestrial ecology relies on...

  12. The Role of Couples’ Interactions in Application of Communication Skills

    OpenAIRE

    منصوره‌السادات صادقی; محمدعلی مظاهری; فرشته موتابی

    2014-01-01

    The aim of this research was to predict the role of couples’ interactions in application of communication skills based on observing their positive and negative interactions. A sample of 31 couples [adapted (15) and maladapted (16)] who were living in Tehran, were selected via accessible sampling. The couples’ interactions were videotaped through a designed scenario including problem solving, decision making, and reviewing conversation about a shared pleasure event. Participants also completed...

  13. Dynamically Authorized Role-Based Access Control for Grid Applications

    Institute of Scientific and Technical Information of China (English)

    YAO Hanbing; HU Heping; LU Zhengding; LI Ruixuan

    2006-01-01

    Grid computing is concerned with the sharing and coordinated use of diverse resources in distributed "virtual organizations". The heterogeneous, dynamic and multi-domain nature of these environments makes challenging security issues that demand new technical approaches. Despite the recent advances in access control approaches applicable to Grid computing, there remain issues that impede the development of effective access control models for Grid applications. Among them there are the lack of context-based models for access control, and reliance on identity or capability-based access control schemes. An access control scheme that resolve these issues is presented, and a dynamically authorized role-based access control (D-RBAC) model extending the RBAC with context constraints is proposed. The D-RABC mechanisms dynamically grant permissions to users based on a set of contextual information collected from the system and user's environments, while retaining the advantages of RBAC model. The implementation architecture of D-RBAC for the Grid application is also described.

  14. Metabolism of {sup 137}cesium, {sup 137}barium in the rat. Therapeutics of the contamination; Metabolisme du {sup 137}cesium, {sup 137}baryum chez le rat. Therapeutique de la contamination

    Energy Technology Data Exchange (ETDEWEB)

    Remy, J; Philippon, A; Lafuma, J; Walter, C [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires. Departement de la Protection Sanitaire, Laboratoire de Radiopathologie

    1967-07-01

    'elimination du {sup 137}Cs - {sup 137}Ba chez le rat. Ils montrent l'independance de ces phenomenes vis-a-vis des modalites d'une administration unique. La distribution tend dans tous les cas vers un schema type qui se maintient ensuite identique a lui-meme en fonction de la charge corporelle. L'analyse biochimique de l'etat du cesium dans les milieux biologiques montre qu'il y est transporte sous une forme libre et ionisee. Abordant le probleme du mode de penetration de l'ion cesium dans le milieu intracellulaire et notamment par l'etude cinetique du systeme plasma-hematie in vivo et in vitro, les auteurs adoptent l'hypothese d'un transport actif du cesium par la membrane cellulaire. Ils en arrivent ainsi a un schema general de la distribution du cesium dans l'organisme, essentiellement caracterise par un equilibre dynamique de repartition entre deux compartiments: 99 pour cent du cesium est accumule dans le pool intracellulaire, 1 pour cent dans les liquides extracellulaires. Ce dernier compartiment est ouvert sur les emonctoires. Du fait du transport actif par les membranes cellulaires, la charge du pool intracellulaire est rapide, mais la decharge est lente. Ce phenomene est le facteur limitant de la decroissance de la charge corporelle. De ce schema les auteurs deduisent les raisons de l'echec relatif des diverses voies therapeutiques explorees a ce jour par eux-memes, et par d'autres auteurs. La stimulation des emonctoires naturels, dans le cas des diuretiques par exemple, ne saurait accroitre que l'epuration du compartiment extracellulaire. Or ce dernier ne contient que 1 pour cent de la charge corporelle et sa recharge est lente. En outre, les procedes visant a contrarier ou inhiber le transport actif du cesium par la membrane cellulaire restent, a ce jour, incompatibles avec la survie de la cellule. (auteurs)

  15. Bioactive Pigments from Marine Bacteria: Applications and Physiological Roles

    Directory of Open Access Journals (Sweden)

    Azamjon B. Soliev

    2011-01-01

    Full Text Available Research into natural products from the marine environment, including microorganisms, has rapidly increased over the past two decades. Despite the enormous difficulty in isolating and harvesting marine bacteria, microbial metabolites are increasingly attractive to science because of their broad-ranging pharmacological activities, especially those with unique color pigments. This current review paper gives an overview of the pigmented natural compounds isolated from bacteria of marine origin, based on accumulated data in the literature. We review the biological activities of marine compounds, including recent advances in the study of pharmacological effects and other commercial applications, in addition to the biosynthesis and physiological roles of associated pigments. Chemical structures of the bioactive compounds discussed are also presented.

  16. The Role of Couples’ Interactions in Application of Communication Skills

    Directory of Open Access Journals (Sweden)

    منصوره‌السادات صادقی

    2014-02-01

    Full Text Available The aim of this research was to predict the role of couples’ interactions in application of communication skills based on observing their positive and negative interactions. A sample of 31 couples [adapted (15 and maladapted (16] who were living in Tehran, were selected via accessible sampling. The couples’ interactions were videotaped through a designed scenario including problem solving, decision making, and reviewing conversation about a shared pleasure event. Participants also completed the Marital Adjustment Test (MAT. The couple’s interactions were coded using the Iranian Couples Interaction Coding System (ICICS. Results revealed that the more increase in positive interactions between couples, the more use of “problem solving” and “negotiation” skills observed, whereas increase in the couples’ negative interactions was associated with less application of this skills. It was also revealed that while the couples’ negative interactions were significantly predictive of using the “decision making” skill, couples with more positive interactions were located in the group who was able to have a review conversation about a shared positive event. In addition, results indicated that couples who were more able to apply problem solving, negotiation, decision making and review conversation about a shared event skills, had also higher scores on marital adjustment. Destructive role of the couples’ negative interactions and intensifying the negative emotions between them has been discussed, as if it seems that couples are not willing to help each other for resolving conflicts. As interactions getting more negative, by creating a negative filtering, memory becomes biased towards negative events at the expense of shared positive events.

  17. Industrial Applications of radioisotopes and radiation technology and Agency's role

    International Nuclear Information System (INIS)

    Ramamoorthy, N.; Haji-Saeid, M.

    2004-01-01

    Applications of radioisotopes and radiation technology are contributing significantly in many areas of science and technology, industry and environment, towards sustainable development, improving the quality of life and cleaner and safer national industries. There are three major classes impacting industrial scale operations, namely, (a) radiation processing/treatment, (b) radiotracer and sealed source techniques to monitor industrial processes/columns/vessels and (c) industrial gamma radiography and tomography. Radiation processing applying gamma sources and electron accelerators for material treatment/modification is an established technology. There are over 160 gamma industrial irradiators and 1300 industrial electron accelerators in operation worldwide. Development of new materials, especially for health care and environment protection, and advanced products (for electronics, solar energy systems, biotechnology etc) are the main objectives of R and D activity in radiation processing technology. The International Atomic Energy Agency (IAEA, Agency) is involved in supporting both the development and transfer of radiation technology. Thanks to Agency's efforts, advanced radiation processing centres have been established in many Member States (MS), e.g. Malaysia, Egypt, Iran, Poland, Brazil, Hungary. Hydrogel dressing for wounds, radiation vulcanised latex, degraded natural polymer are examples of useful product outcomes. Demonstration of effective treatment of flue gas in pilot plant as well as industrial scale and industrial wastewater in pilot plant scale has shown promise for tackling industrial emissions/effluents using electron beam machines. Industrial radiotracer and gamma sealed source techniques are largely used for analyzing industrial process systems. Initially used as trouble-shooting measures, they play a vital role in process parameter optimization, improved productivity, on-line monitoring and could lead to even pre-commissioning benchmarking. Gamma

  18. Industrial Applications of radioisotopes and radiation technology and Agency's role

    International Nuclear Information System (INIS)

    Ramamoorthy, N.; Haji-Saeid, M.

    2004-01-01

    Full text: Applications of radioisotopes and radiation technology are contributing significantly in many areas of science and technology, industry and environment, towards sustainable development, improving the quality of life and cleaner and safer national industries. There are three major classes impacting industrial scale operations, namely, (a) radiation processing/treatment, (b) radiotracer and sealed source techniques to monitor industrial processes/columns/vessels and (c) industrial gamma radiography and tomography. Radiation processing applying gamma sources and electron accelerators for material treatment/modification is an established technology. There are over 160 gamma industrial irradiators and 1300 industrial electron accelerators in operation worldwide. Development of new materials, especially for health care and environment protection, and advanced products (for electronics, solar energy systems, biotechnology etc) are the main objectives of R and D activity in radiation processing technology. The International Atomic Energy Agency (IAEA, Agency) is involved in supporting both the development and transfer of radiation technology. Thanks to Agency's efforts, advanced radiation processing centres have been established in many Member States (MS), e.g. Malaysia, Egypt, Iran, Poland, Brazil, Hungary. Hydrogel dressing for wounds, radiation vulcanised latex, degraded natural polymer are examples of useful product outcomes. Demonstration of effective treatment of flue gas in pilot plant as well as industrial scale and industrial wastewater in pilot plant scale has shown promise for tackling industrial emissions/effluents using electron beam machines. Industrial radiotracer and gamma sealed source techniques are largely used for analyzing industrial process systems. Initially used as trouble-shooting measures, they play a vital role in process parameter optimization, improved productivity, on-line monitoring and could lead to even pre

  19. Rhinorrhee cerebrospinale : difficulties therapeutiques et facteurs d ...

    African Journals Online (AJOL)

    Objectives: illustrate the different modalities of treatment of CSr and the causes of failure. Patients et méthodes : a total of 15 patients with CSF rhinorrhea(6 traumatic, 2 iatrogenic, and 7 spontaneous) were treated in our institution during an 11-year period (2000-2011). Results: The average patient age was 44, 9 years.

  20. Aspects epidemiologiques, cliniques et therapeutiques de la ...

    African Journals Online (AJOL)

    O. Ndour

    Une hernie inguinale était retrouvée chez 11 patients (9%). Chez deux enfants, la cryptorchidie bilatérale entrait dans le cadre d'un syndrome de. Prune Belly. Aucune échographie n'a été réalisée chez nos patients. Les aspects thérapeutiques et évolutifs. La majeure partie de nos patients (n = 95 soit 77,2%) a été opérée.

  1. imperforation choanale aspects cliniques, approche therapeutique

    African Journals Online (AJOL)

    17 déc. 2006 ... INTRODUCTION. L'atrésie choanale est une malformation congénitale qui consiste en une obstruction totale ou subtotale des ori- fices postérieurs des fosses nasales. Il s'agit d'une affec- tion relativement rare (1 pour 5000 à 8000 naissances). Plusieurs théories pathogéniques ont été avancées, elles.

  2. Metabolism of {sup 137}cesium, {sup 137}barium in the rat. Therapeutics of the contamination; Metabolisme du {sup 137}cesium, {sup 137}baryum chez le rat. Therapeutique de la contamination

    Energy Technology Data Exchange (ETDEWEB)

    Remy, J.; Philippon, A.; Lafuma, J.; Walter, C. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires. Departement de la Protection Sanitaire, Laboratoire de Radiopathologie

    1967-07-01

    'elimination du {sup 137}Cs - {sup 137}Ba chez le rat. Ils montrent l'independance de ces phenomenes vis-a-vis des modalites d'une administration unique. La distribution tend dans tous les cas vers un schema type qui se maintient ensuite identique a lui-meme en fonction de la charge corporelle. L'analyse biochimique de l'etat du cesium dans les milieux biologiques montre qu'il y est transporte sous une forme libre et ionisee. Abordant le probleme du mode de penetration de l'ion cesium dans le milieu intracellulaire et notamment par l'etude cinetique du systeme plasma-hematie in vivo et in vitro, les auteurs adoptent l'hypothese d'un transport actif du cesium par la membrane cellulaire. Ils en arrivent ainsi a un schema general de la distribution du cesium dans l'organisme, essentiellement caracterise par un equilibre dynamique de repartition entre deux compartiments: 99 pour cent du cesium est accumule dans le pool intracellulaire, 1 pour cent dans les liquides extracellulaires. Ce dernier compartiment est ouvert sur les emonctoires. Du fait du transport actif par les membranes cellulaires, la charge du pool intracellulaire est rapide, mais la decharge est lente. Ce phenomene est le facteur limitant de la decroissance de la charge corporelle. De ce schema les auteurs deduisent les raisons de l'echec relatif des diverses voies therapeutiques explorees a ce jour par eux-memes, et par d'autres auteurs. La stimulation des emonctoires naturels, dans le cas des diuretiques par exemple, ne saurait accroitre que l'epuration du compartiment extracellulaire. Or ce dernier ne contient que 1 pour cent de la charge corporelle et sa recharge est lente. En outre, les procedes visant a contrarier ou inhiber le transport actif du cesium par la membrane cellulaire restent, a ce jour, incompatibles avec la survie de la cellule. (auteurs)

  3. Distributed Role-based Access Control for Coaliagion Application

    Institute of Scientific and Technical Information of China (English)

    HONG Fan; ZHU Xian; XING Guanglin

    2005-01-01

    Access control in multi-domain environments is one of the important questions of building coalition between domains.On the basis of RBAC access control model, the concepts of role delegation and role mapping are proposed, which support the third-party authorization.Then, a distributed RBAC model is presented.Finally the implementation issues are discussed.

  4. The Role of Participatory Design in Mobile Application Development

    Science.gov (United States)

    Hamzah, Almed

    2018-03-01

    Mobile devices are used by people worldwide. It becomes a common equipment to complete a day-to-day activity. Inside the devices, there are numerous mobile applications that have been built for various needs. Some of these are quite successful while the other are not. The development of successful mobile application faces several challenges. In this research, we want to explore the use of participatory design method in mobile application development. Particularly, the aim of the study is to answer the question whether participatory design method has a place in the realm of mobile application development. We established two sessions of workshop to accommodate the participant to take part in the development process of mobile application. The result shows that participatory design method can determine how the user will deal with the limitations of mobile devices. It helps user to create a particular form of interaction that meets mobile devices characteristics.

  5. Prospects of HTGR process heat application and role of HTTR

    International Nuclear Information System (INIS)

    Shiozawa, S.; Miyamoto, Y.

    2000-01-01

    At Japan Atomic Energy Research Institute, an effort on development of process heat application with high temperature gas cooled reactor (HTGR) has been continued for providing a future clean alternative to the burning of fossil energy for the production of industrial process heat. The project is named 'HTTR Heat Utilization Project', which includes a demonstration of hydrogen production using the first Japanese HTGR of High Temperature Engineering Test Reactor (HTTR). In the meantime, some countries, such as China, Indonesia, Russia and South Africa are trying to explore the HTGR process heat application for industrial use. One of the key issues for this application is economy. It has been recognized for a long time and still now that the HTGR heat application system is not economically competitive to the current fossil ones, because of the high cost of the HTGR itself. However, the recent movement on the HTGR development, as represented by South Africa Pebble Beds Modular Reactor (SA-PBMR) Project, has revealed that the HTGRs are well economically competitive in electricity production to fossil fuel energy supply under a certain condition. This suggests that the HTGR process heat application will also possibly get economical in the near future. In the present paper, following a brief introduction describing the necessity of the HTGRs for the future process heat application, Japanese activities and prospect of the development on the process heat application with the HTGRs are described in relation with the HTTR Project. In conclusion, the process heat application system with HTGRs is thought technically and economically to be one of the most promising applications to solve the global environmental issues and energy shortage which may happen in the future. However, the commercialization for the hydrogen production system from water, which is the final goal of the HTGR process heat application, must await the technology development to be completed in 2030's at the

  6. The role of EEPROM devices in upcoming ISDN applications

    Science.gov (United States)

    Nette, Herbert L.

    1991-02-01

    Integrated Services Digital Network (ISDN) equipments are rapidly becoming a major market for semiconductor chips. Although at first glance this growing market appears to be geared at logic chips, nonvolatile memories represent important support chips and will become a significant segment of this market. Challenges in these applications consist in operating EEPROMs at lower voltages and lower power and embedding them on ever more complex communications processor chips.

  7. Role of optical computers in aeronautical control applications

    Science.gov (United States)

    Baumbick, R. J.

    1981-01-01

    The role that optical computers play in aircraft control is determined. The optical computer has the potential high speed capability required, especially for matrix/matrix operations. The optical computer also has the potential for handling nonlinear simulations in real time. They are also more compatible with fiber optic signal transmission. Optics also permit the use of passive sensors to measure process variables. No electrical energy need be supplied to the sensor. Complex interfacing between optical sensors and the optical computer is avoided if the optical sensor outputs can be directly processed by the optical computer.

  8. Emerging battery research in Indonesia: The role of nuclear applications

    Energy Technology Data Exchange (ETDEWEB)

    Kartini, E. [Science and Technology Center for Advanced Materials, National Nuclear Energy Agency, South Tangerang (Indonesia)

    2015-12-31

    Development of lithium ion batteries will play an important role in achieving innovative sustainable energy. To reduce the production cost of such batteries, the Indonesian government has instituted a strategy to use local resources. Therefore, this technology is now part of the National Industrial Strategic Plan. One of the most important scientific challenges is to improve performance of lithium batteries. Neutron scattering is a very important technique to investigate crystal structure of electrode materials. The unique properties of neutrons, which allow detection of light elements such as lithium ions, are indispensable. The utilization of neutron scattering facilities at the Indonesian National Nuclear Energy Agency will provide significant contributions to the development of improved lithium ion battery technologies.

  9. Emerging battery research in Indonesia: The role of nuclear applications

    International Nuclear Information System (INIS)

    Kartini, E.

    2015-01-01

    Development of lithium ion batteries will play an important role in achieving innovative sustainable energy. To reduce the production cost of such batteries, the Indonesian government has instituted a strategy to use local resources. Therefore, this technology is now part of the National Industrial Strategic Plan. One of the most important scientific challenges is to improve performance of lithium batteries. Neutron scattering is a very important technique to investigate crystal structure of electrode materials. The unique properties of neutrons, which allow detection of light elements such as lithium ions, are indispensable. The utilization of neutron scattering facilities at the Indonesian National Nuclear Energy Agency will provide significant contributions to the development of improved lithium ion battery technologies

  10. Monoterpenol Oxidative Metabolism: Role in Plant Adaptation and Potential Applications

    Science.gov (United States)

    Ilc, Tina; Parage, Claire; Boachon, Benoît; Navrot, Nicolas; Werck-Reichhart, Danièle

    2016-01-01

    Plants use monoterpenols as precursors for the production of functionally and structurally diverse molecules, which are key players in interactions with other organisms such as pollinators, flower visitors, herbivores, fungal, or microbial pathogens. For humans, many of these monoterpenol derivatives are economically important because of their pharmaceutical, nutraceutical, flavor, or fragrance applications. The biosynthesis of these derivatives is to a large extent catalyzed by enzymes from the cytochrome P450 superfamily. Here we review the knowledge on monoterpenol oxidative metabolism in plants with special focus on recent elucidations of oxidation steps leading to diverse linalool and geraniol derivatives. We evaluate the common features between oxidation pathways of these two monoterpenols, such as involvement of the CYP76 family, and highlight the differences. Finally, we discuss the missing steps and other open questions in the biosynthesis of oxygenated monoterpenol derivatives. PMID:27200002

  11. Indispensable role of biochar-inherent mineral constituents in its environmental applications: A review.

    Science.gov (United States)

    Xu, Xiaoyun; Zhao, Yinghao; Sima, Jingke; Zhao, Ling; Mašek, Ondřej; Cao, Xinde

    2017-10-01

    Biochar typically consists of both carbon and mineral fractions, and the carbon fraction has been generally considered to determine its properties and applications. Recently, an increasing body of research has demonstrated that mineral components inherent in biochar, such as alkali or alkaline earth metals in the form of carbonates, phosphates, or oxides, could also influence the properties and thus the applications. The review articles published thus far have mainly focused on multiple environmental and agronomic applications of biochar, including carbon sequestration, soil improvement, environmental remediation, etc. This review aims to highlight the indispensable role of the mineral fraction of biochar in these different applications, especially in environmental applications. Specifically, it provides a critical review of current research findings related to the mineral composition of biochar and the effect of the mineral fraction on the physicochemical properties, contaminant sorption, carbon retention and stability, and nutrient bioavailability of biochar. Furthermore, the role of minerals in the emerging applications of biochar, as a precursor for fuel cells, supercapacitors, and photoactive components, is also summarized. Overall, inherent minerals should be fully considered while determining the most appropriate application for any given biochar. A thorough understanding of the role of biochar-bound minerals in different applications will also allow the design or selection of the most suitable biochar for specific applications based on the consideration of feedstock composition, production parameters, and post-treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Role of IAEA in non-electric applications of nuclear energy

    International Nuclear Information System (INIS)

    Kupitz, J.

    1997-01-01

    Worldwide, approximately 30% of total primary energy is used to produce electricity. Most of the remaining 70% is either used for transportation or is converted into hot water, steam and heat. The International Atomic Energy Agency is a specialized agency within the United Nations family whose role includes the development and practical application of atomic energy for peaceful uses throughout the world. The focus of this paper is on those applications associated with district heating and process heat production for industrial use. 14 refs, 3 figs, 1 tab

  13. A comprehensive review of cryogels and their roles in tissue engineering applications.

    Science.gov (United States)

    Hixon, Katherine R; Lu, Tracy; Sell, Scott A

    2017-10-15

    The extracellular matrix is fundamental in providing an appropriate environment for cell interaction and signaling to occur. Replicating such a matrix is advantageous in the support of tissue ingrowth and regeneration through the field of tissue engineering. While scaffolds can be fabricated in many ways, cryogels have recently become a popular approach due to their macroporous structure and durability. Produced through the crosslinking of gel precursors followed by a subsequent controlled freeze/thaw cycle, the resulting cryogel provides a unique, sponge-like structure. Therefore, cryogels have proven advantageous for many tissue engineering applications including roles in bioreactor systems, cell separation, and scaffolding. Specifically, the matrix has been demonstrated to encourage the production of various molecules, such as antibodies, and has also been used for cryopreservation. Cryogels can pose as a bioreactor for the expansion of cell lines, as well as a vehicle for cell separation. Lastly, this matrix has shown excellent potential as a tissue engineered scaffold, encouraging regrowth at numerous damaged tissue sites in vivo. This review will briefly discuss the fabrication of cryogels, with an emphasis placed on their application in various facets of tissue engineering to provide an overview of this unique scaffold's past and future roles. Cryogels are unique scaffolds produced through the controlled freezing and thawing of a polymer solution. There is an ever-growing body of literature that demonstrates their applicability in the realm of tissue engineering as extracellular matrix analogue scaffolds; with extensive information having been provided regarding the fabrication, porosity, and mechanical integrity of the scaffolds. Additionally, cryogels have been reviewed with respect to their role in bioseparation and as cellular incubators. This all-inclusive view of the roles that cryogels can play is critical to advancing the technology and expanding its

  14. Validation plays the role of a "bridge" in connecting remote sensing research and applications

    Science.gov (United States)

    Wang, Zhiqiang; Deng, Ying; Fan, Yida

    2018-07-01

    Remote sensing products contribute to improving earth observations over space and time. Uncertainties exist in products of different levels; thus, validation of these products before and during their applications is critical. This study discusses the meaning of validation in depth and proposes a new definition of reliability for use with such products. In this context, validation should include three aspects: a description of the relevant uncertainties, quantitative measurement results and a qualitative judgment that considers the needs of users. A literature overview is then presented evidencing improvements in the concepts associated with validation. It shows that the root mean squared error (RMSE) is widely used to express accuracy; increasing numbers of remote sensing products have been validated; research institutes contribute most validation efforts; and sufficient validation studies encourage the application of remote sensing products. Validation plays a connecting role in the distribution and application of remote sensing products. Validation connects simple remote sensing subjects with other disciplines, and it connects primary research with practical applications. Based on the above findings, it is suggested that validation efforts that include wider cooperation among research institutes and full consideration of the needs of users should be promoted.

  15. Role of organic amendment application on greenhouse gas emission from soil

    Energy Technology Data Exchange (ETDEWEB)

    Thangarajan, Ramya, E-mail: thary008@mymail.unisa.edu.au [Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes, SA 5095 (Australia); Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, Adelaide, SA 5095 (Australia); Bolan, Nanthi S. [Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes, SA 5095 (Australia); Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, Adelaide, SA 5095 (Australia); Tian, Guanglong [Environmental Monitoring and Research Division, Monitoring and Research Dep., Metropolitan Water Reclamation District of Greater Chicago, 6001, Pershing Road, Cicero, IL 60804 (United States); Naidu, Ravi [Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes, SA 5095 (Australia); Cooperative Research Centre for Contamination Assessment and Remediation of the Environment, Adelaide, SA 5095 (Australia); Kunhikrishnan, Anitha [Chemical Safety Division, Department of Agro-Food Safety, National Academy of Agricultural Science,10 Suwon-si, Gyeonggi-do (Korea, Republic of)

    2013-11-01

    Globally, substantial quantities of organic amendments (OAs) such as plant residues (3.8 × 10{sup 9} Mg/yr), biosolids (10 × 10{sup 7} Mg/yr), and animal manures (7 × 10{sup 9} Mg/yr) are produced. Recycling these OAs in agriculture possesses several advantages such as improving plant growth, yield, soil carbon content, and microbial biomass and activity. Nevertheless, OA applications hold some disadvantages such as nutrient eutrophication and greenhouse gas (GHG) emission. Agriculture sector plays a vital role in GHG emission (carbon dioxide— CO{sub 2}, methane— CH{sub 4}, and nitrous oxide— N{sub 2}O). Though CH{sub 4} and N{sub 2}O are emitted in less quantity than CO{sub 2}, they are 21 and 310 times more powerful in global warming potential, respectively. Although there have been reviews on the role of mineral fertilizer application on GHG emission, there has been no comprehensive review on the effect of OA application on GHG emission in agricultural soils. The review starts with the quantification of various OAs used in agriculture that include manures, biosolids, and crop residues along with their role in improving soil health. Then, it discusses four major OA induced-GHG emission processes (i.e., priming effect, methanogenesis, nitrification, and denitrification) by highlighting the impact of OA application on GHG emission from soil. For example, globally 10 × 10{sup 7} Mg biosolids are produced annually which can result in the potential emission of 530 Gg of CH{sub 4} and 60 Gg of N{sub 2}O. The article then aims to highlight the soil, climatic, and OA factors affecting OA induced-GHG emission and the management practices to mitigate the emission. This review emphasizes the future research needs in relation to nitrogen and carbon dynamics in soil to broaden the use of OAs in agriculture to maintain soil health with minimum impact on GHG emission from agriculture. - Highlights: ► A comprehensive overview for the first time on GHG emission from

  16. Diversity, Roles, and Biotechnological Applications of Symbiotic Microorganisms in the Gut of Termite.

    Science.gov (United States)

    Zhou, Jing; Duan, Jiwei; Gao, Mingkun; Wang, Ying; Wang, Xiaohua; Zhao, Kai

    2018-05-12

    Termites are global pests and can cause serious damage to buildings, crops, and plantation forests. The symbiotic intestinal flora plays an important role in the digestion of cellulose and nitrogen in the life of termites. Termites and their symbiotic microbes in the gut form a synergistic system. These organism work together to digest lignocellulose to make the termites grow on nitrogen deficient food. In this paper, the diversity of symbiotic microorganisms in the gut of termites, including protozoan, spirochetes, actinomycetes, fungus and bacteria, and their role in the digestion of lignocellulose and also the biotechnological applications of these symbiotic microorganisms are discussed. The high efficiency lignocellulose degradation systems of symbiotic microbes in termite gut not only provided a new way of biological energy development, but also has immense prospect in the application of cellulase enzymes. In addition, the study on the symbiotic microorganisms in the gut of termites will also provide a new method for the biological control of termites by the endophytic bacteria in the gut of termites.

  17. Fostering applications of neutron scattering techniques in developing countries: IAEA's role

    Energy Technology Data Exchange (ETDEWEB)

    Paranjpe, Shriniwas K. [Division of Physical and Chemical Sciences, International Atomic Energy Agency, Wagramer Strasse 5, A-1400 Vienna (Austria)]. E-mail: S.K.Paranjpe@iaea.org; Mank, G. [Division of Physical and Chemical Sciences, International Atomic Energy Agency, Wagramer Strasse 5, A-1400 Vienna (Austria); Ramamoorthy, N. [Division of Physical and Chemical Sciences, International Atomic Energy Agency, Wagramer Strasse 5, A-1400 Vienna (Austria)

    2006-11-15

    Over the last 60 years research reactors have played an important role in technological and socio-economical development of mankind. Neutron scattering has been the workhorse for research and development in materials science. Developing countries with moderate flux research reactors have also been involved in using this technique. The reactors and the facilities around them have a large potential for applications, while their under-utilization has been a concern for many member states. The International Atomic Energy Agency (IAEA) has been supporting its member states in the enhancement of utilization of their research reactors. Technical meetings focussing on the area of current interests with potential applications are organized under the project on 'effective utilization of research reactors,' e.g. on residual stress measurement, neutron reflectometry. Coordinated research projects (CRPs) bring together scientists from developed and developing countries, build collaborations, and exchange expertise and technology. The CRPs on research reactor utilization include topics like development of small-angle neutron scattering applications and development of sources and imaging systems for neutron radiography. New CRPs on the measurement of residual stress and accelerator-driven neutron sources will be initiated soon. The results from these meetings of CRPs are published as technical documents of the IAEA that would act as guidelines for capacity building for research reactor managers. This paper will present some of the salient features of IAEA activities in promoting research reactor utilization.

  18. The Role of Technology in Science Teaching Activities: Web Based Teaching Applications

    Directory of Open Access Journals (Sweden)

    Fatma ALKAN

    2016-12-01

    Full Text Available 2015 Abstract In this research the attitudes of pre-service teachers studying at Hacettepe University, Division of Science Education towards the importance of technological equipment in chemistry education activities and how effective they find technology in teaching different skills and applications have been examined. Pre-test/post-test control group design has been used in the research. In the experimental group Titrimetric Analysis has been conducted with simulations supported web based instruction and in the control group with teacher-centered instruction. In general, it has been found out that the attitudes of pre-service teachers in experiment group towards the importance of technological equipment as a teaching tool in chemistry are more positive than those in control group. In other words, statistically significant differences have occurred in attitudes of pre-service teachers in both experiment and control group towards the role of technology in chemistry teaching activities after web based teaching.

  19. Understanding the role of thiol and disulfide self-assembled DNA receptor monolayers for biosensing applications.

    Science.gov (United States)

    Carrascosa, Laura G; Martínez, Lidia; Huttel, Yves; Román, Elisa; Lechuga, Laura M

    2010-09-01

    A detailed study of the immobilization of three differently sulfur-modified DNA receptors for biosensing applications is presented. The three receptors are DNA-(CH)n-SH-, DNA-(CH)n-SS-(CH)n-DNA, and DNA-(CH)n-SS-DMTO. Nanomechanical and surface plasmon resonance biosensors and fluorescence and radiolabelling techniques were used for the experimental evaluation. The results highlight the critical role of sulfur linker type in DNA self-assembly, affecting the kinetic adsorption and spatial distribution of DNA chains within the monolayer and the extent of chemisorption and physisorption. A spacer (mercaptohexanol, MCH) is used to evaluate the relative efficiencies of chemisorption of the three receptors by analysing the extent to which MCH can remove physisorbed molecules from each type of monolayer. It is demonstrated that -SH derivatization is the most suitable for biosensing purposes as it results in densely packed monolayers with the lowest ratio of physisorbed probes.

  20. Application of a hierarchical enzyme classification method reveals the role of gut microbiome in human metabolism.

    Science.gov (United States)

    Mohammed, Akram; Guda, Chittibabu

    2015-01-01

    vitamins. The ECemble method is able to hierarchically assign high quality enzyme annotations to genomic and metagenomic data. This study demonstrated the real application of ECemble to understand the indispensable role played by microbe-encoded enzymes in the healthy functioning of human metabolic systems.

  1. Application of a hierarchical enzyme classification method reveals the role of gut microbiome in human metabolism

    Science.gov (United States)

    2015-01-01

    , cofactors and vitamins. Conclusions The ECemble method is able to hierarchically assign high quality enzyme annotations to genomic and metagenomic data. This study demonstrated the real application of ECemble to understand the indispensable role played by microbe-encoded enzymes in the healthy functioning of human metabolic systems. PMID:26099921

  2. Applicability of the EULAR recommendations on the role of the nurse in the management of chronic inflammatory arthritis in Portugal Applicability of the EULAR recommendations on the role of the nurse in the management of chronic inflammatory arthritis in Portugal

    NARCIS (Netherlands)

    Barbosa, L.; Ramiro, S.; Santos, M. J.; Canas da Silva, J.

    2013-01-01

    Objectives: To evaluate the level of agreement and applicability of the EULAR recommendations for the role of the nurse in the management of chronic inflammatory arthritis in Portugal. Methods: Nurses from all Portuguese rheumatology centers were invited to fill-in a questionnaire addressing the

  3. Profils clinique, biologique et therapeutique des enfants infectes par ...

    African Journals Online (AJOL)

    Introduction : La prise en charge du VIH pédiatrique reste un maillon faible de la riposte au Togo. Le but de notre travail est de décrire les caractéristiques cliniques, immunologiques et thérapeutiques des enfants infectés au Centre Hospitalier Régional de Lomé-Commune (CHR-LC). Matériels et méthode : Cette étude ...

  4. Inobservance therapeutique aux anti-retroviraux chez les personnes ...

    African Journals Online (AJOL)

    Buts : Rechercher les facteurs psychologiques ou psychosociaux responsables de l'inobservance thérapeutique (IBT) aux antiretroviraux (ARV) Méthodologie : Il s'agit d'une étude transversale sur 06 mois (mai - octobre 2008) menée au centre de promotion sociale à Lomé chez les personnes vivant avec le VIH (PVVIH) ...

  5. Carbon Turnover during Effluent Application to the Land: A Potential Role for Vegetation?

    Directory of Open Access Journals (Sweden)

    Vasileios A. Tzanakakis

    2015-01-01

    Full Text Available This work investigates the effect of plant species (Eucalyptus camaldulensis vs. Arundo donax on carbon (C turnover during wastewater application to the land. The study was carried out in 40-liter pots under field conditions and plant species were treated either with pre-treated municipal wastewater or freshwater. Plant species had a strong effect on soil organic matter with pots planted with E. camaldulensis showing greater values than pots planted with A. donax. In accordance, greater respiration rates were measured in E. camaldulensis pots compared to those planted with A. donax. The respiration rate followed a decreasing trend with the progress of the season for both species. These findings suggest differences in soil microbial community composition and/or activity in the rhizosphere of plant species. Minor effects of plant species or effluent were observed in dissolved organic carbon, protein, and hexoses content. In conclusion, the results of the present study reveal an important role of plant species on C cycling in terrestrial environments with potential implications on the sequestration of C and release of nutrients and pollutants.

  6. Fostering the local production and application of industrial radiotracers in developing countries - IAEA's role

    International Nuclear Information System (INIS)

    Mohammad Haji-Saeid, S.; Jin, Joon-Ha; Ramamoorthy, Natesan; )

    2006-01-01

    Radiotracer techniques provide fast and accurate information for solving various process problems in industrial plants. The IAEA is playing an important role in supporting the development and transfer of radiotracer techniques to developing countries. The IAEA has implemented 5 coordinated research projects (CRP), including two on-going projects, in the field of radiotracer and sealed source applications in industry. The CRPs facilitated the acquisition and dissemination of know-how and technology for wear/corrosion measurement, residence time: distribution (RTD) study, validation of computed fluid dynamics data, industrial process tomography and inter-well connectivity study. A number of technical cooperation projects have been executed to strengthen the capability of radiotracer groups in developing Member States and to create awareness in the industries about the technical and economical benefits of radiotracer technology. The IAEA's regional projects have strongly impacted the transfer and adoption of the techniques. The status of radiotracer use in developing countries reveals that the lack of timely availability of radiotracers as one of the major problems. Development of some radionuclide generators is a possible solution. Cooperation among the international radiotracer communities is necessary to enhance the availability and use of radiotracers in developing countries. (author)

  7. Narrative review: the role of leptin in human physiology: emerging clinical applications.

    Science.gov (United States)

    Kelesidis, Theodore; Kelesidis, Iosif; Chou, Sharon; Mantzoros, Christos S

    2010-01-19

    Leptin is a hormone secreted by adipose tissue in direct proportion to amount of body fat. The circulating leptin levels serve as a gauge of energy stores, thereby directing the regulation of energy homeostasis, neuroendocrine function, and metabolism. Persons with congenital deficiency are obese, and treatment with leptin results in dramatic weight loss through decreased food intake and possible increased energy expenditure. However, most obese persons are resistant to the weight-reducing effects of leptin. Recent studies suggest that leptin is physiologically more important as an indicator of energy deficiency, rather than energy excess, and may mediate adaptation by driving increased food intake and directing neuroendocrine function to converse energy, such as inducing hypothalamic hypogonadism to prevent fertilization. Current studies investigate the role of leptin in weight-loss management because persons who have recently lost weight have relative leptin deficiency that may drive them to regain weight. Leptin deficiency is also evident in patients with diet- or exercise-induced hypothalamic amenorrhea and lipoatrophy. Replacement of leptin in physiologic doses restores ovulatory menstruation in women with hypothalamic amenorrhea and improves metabolic dysfunction in patients with lipoatrophy, including lipoatrophy associated with HIV or highly active antiretroviral therapy. The applications of leptin continue to grow and will hopefully soon be used therapeutically.

  8. Role of MNRC to Develop Knowledge and Skills in Nuclear Applications

    International Nuclear Information System (INIS)

    Marfak, T.; Krafes, H.

    2016-01-01

    Full text: Since 2003, CNESTEN is operating Maamora Nuclear Research Center MNRC which is including a 2 MW nuclear reactor and a dozen of specialized nuclear techniques laboratories dedicated to earth sciences, human health, industry, safety and security, radioactive waste management, and so on. Preparing the required qualified human resources needed investment in terms of identification of necessary competencies, training and expertise development. Human Resources and Communication Department established a strategy to lead with the CNESTEN overall vision and strategic objectives. As a result, modern HR tools were established such as: competencies repository, systematic approach for training SAT, multi-annual training program, evaluation system, etc. This paper will present all the HR projects identified and developed targeting the CNESTEN scientific and technical staff. The objective is to sustain the CNESTEN activities by qualifying its human resources, developing knowledgeand expertise at both the individual and collective levels. Furthermore, CNESTEN is playing a major role in the transfer of nuclear techniques applications knowledge to several African countries. This experience will be presented in this paper as well. (author

  9. The role of electromagnetic separators in the production of radiotracers for bio-medical research and nuclear medical application

    CERN Document Server

    Beyer, Gerd-Jürgen

    2003-01-01

    With the growing complexity of positron emission tomography/single photon emission computed tomography imaging and the new developments in systemic radionuclide therapy there is a growing need for radioisotope preparations with higher radiochemical and radionuclidic purity that has not been achievable before. Especially important for the new applications is the specific activity of the radiotracer. Conventional methods in medical isotope production have reached their technical limitations. The role of isotope separators is discussed with examples of typical production and characterization experiments conducted at the ISOLDE and TRIUMF facilities. These preliminary experiments indicate that isotope separators have a definite role to play in the future for the production of radioisotopes for biomedical research and medical application.

  10. THE ROLE OF RADIATION ACCIDENTS AND INDUSTRIAL APPLICATIONS OF IONIZING RADIATION SOURCES IN THE PROBLEM OF RADIATION DAMAGE

    OpenAIRE

    Кіхтенко, Ігор Миколайович

    2016-01-01

    Subject of research – the relevance of radiation damage at modern development of industry and medicine. In the world of radiation sources used in different fields of practice and their application in the future will increase, which greatly increases the likelihood of injury in a significant contingent of people.Research topic – the definition of the role of nuclear energy and the industrial use of ionizing radiation sources in the problem of radiation damage. The purpose of research – identif...

  11. The Role of the Web Server in a Capstone Web Application Course

    Science.gov (United States)

    Umapathy, Karthikeyan; Wallace, F. Layne

    2010-01-01

    Web applications have become commonplace in the Information Systems curriculum. Much of the discussion about Web development for capstone courses has centered on the scripting tools. Very little has been discussed about different ways to incorporate the Web server into Web application development courses. In this paper, three different ways of…

  12. The role of organizational strategy in the user-centered design of mobile applications

    NARCIS (Netherlands)

    Eshet, Eyal; de Reuver, G.A.; Bouwman, W.A.G.A.

    2017-01-01

    Gathering insights on users and the contexts they use mobile applications is at the core of the user-centered design (UCD). Organizations find it strategically important to efficiently and effectively use these insights. With the proliferation of mobile applications, gaining timely and relevant

  13. The environmental health officer's role in the determination of wind turbine applications

    International Nuclear Information System (INIS)

    Spode, D.

    1993-01-01

    An account is given from the Local Authority Environmental Health view point about the application for Deli Wind Farm, Delabole, Cornwall, UK, which was the first such application we received and was approved and is now operational. Subsequently we have approved the application for Cold Northcott, have refused two other applications and a further two are being processed. The account will indicate the practical problems faced by Environment Health Officers in assessing applications and advising the decision makers. An indication of the information which the author considers it is essential to have included in the noise section of an environmental assessment is given and suggestions are made on the type of conditions which should be attached to any planning consent with a view to protecting occupiers of the closest dwelling, this being particularly important where the relevant separation distances give little room for error in getting the decision right. (author)

  14. Applicant Reactions to Selection Events : Four studies into the role of attributional style and fairness perceptions

    NARCIS (Netherlands)

    Schinkel, S.; van Vianen, A.E.M.; Ryan, A.M.

    2016-01-01

    In four studies, applicants’ (N = 478) organizational attractiveness perceptions and recommendation intentions following selection outcomes were measured. In three field studies, actual applicants’ perceptions were measured in authentic, high-stakes application contexts, both preprocedure and

  15. Electrospun chitosan nanofibre membranes for antimicrobial application: role of electrospinning processing parameters

    CSIR Research Space (South Africa)

    Jacobs, V

    2010-01-01

    Full Text Available for biomedical applications such as wound dressing. In this paper, the authors report investigation on the effects of governing parameters on the formation of chitosan nanofibre membranes. These membranes were subjected to various cell cultures for antibacterial...

  16. INNOVATION AND INFORMATION TECHNOLGY: The role of Mobile application Inducing Innovations in Restaurant Businesses

    OpenAIRE

    Khadka, Ganesh Bahadur

    2014-01-01

    This thesis is a part of investigation to explain the relationship between information technology and innovation. MORSA ,Mobile Optimized Restaurant Service Application, was developed as a means of information technology by upgrading with new features comparing with currently existing online application service for restaurant businesses. With the help of MORSA,this research was conducted by examining its potentiaily to explain the relationship with different types of innovations. Moreover, di...

  17. A virtual reality application in role-plays of social skills training for schizophrenia: a randomized, controlled trial.

    Science.gov (United States)

    Park, Kyung-Min; Ku, Jeonghun; Choi, Soo-Hee; Jang, Hee-Jeong; Park, Ji-Yeon; Kim, Sun I; Kim, Jae-Jin

    2011-09-30

    Although social skills training (SST) is an effective approach for improving social skills for schizophrenia, the motivational deficit attenuates its efficacy. Virtual reality (VR) applications have allowed individuals with mental disabilities to enhance their motivation for rehabilitation. We compared SST using VR role-playing (SST-VR) to SST using traditional role-playing (SST-TR). This randomized, controlled trial included 91 inpatients with schizophrenia who were assigned to either SST-VR (n=46) or SST-TR (n=45). Both groups were administered over 10 semiweekly group sessions. An experienced, blinded rater assessed vocal, nonverbal and conversational skills. We also obtained data on motivation for SST and various social abilities. Throughout the 10 sessions, the SST-VR group (n=33) showed greater interest in SST and generalization of the skills than the SST-TR group (n=31). After SST, the SST-VR group improved more in conversational skills and assertiveness than the SST-TR group, but less in nonverbal skills. The VR application in role-plays of SST for schizophrenia may be particularly beneficial in terms of improving the conversational skills and assertiveness, possibly through its advantages in enhancing motivation for SST and generalization of the skills, and thus it may be a useful supplement to traditional SST. Copyright © 2011 Elsevier Ltd. All rights reserved.

  18. TME2/342: The Role of the EXtensible Markup Language (XML) for Future Healthcare Application Development

    Science.gov (United States)

    Noelle, G; Dudeck, J

    1999-01-01

    Two years, since the World Wide Web Consortium (W3C) has published the first specification of the eXtensible Markup Language (XML) there exist some concrete tools and applications to work with XML-based data. In particular, new generation Web browsers offer great opportunities to develop new kinds of medical, web-based applications. There are several data-exchange formats in medicine, which have been established in the last years: HL-7, DICOM, EDIFACT and, in the case of Germany, xDT. Whereas communication and information exchange becomes increasingly important, the development of appropriate and necessary interfaces causes problems, rising costs and effort. It has been also recognised that it is difficult to define a standardised interchange format, for one of the major future developments in medical telematics: the electronic patient record (EPR) and its availability on the Internet. Whereas XML, especially in an industrial environment, is celebrated as a generic standard and a solution for all problems concerning e-commerce, in a medical context there are only few applications developed. Nevertheless, the medical environment is an appropriate area for building XML applications: as the information and communication management becomes increasingly important in medical businesses, the role of the Internet changes quickly from an information to a communication medium. The first XML based applications in healthcare show us the advantage for a future engagement of the healthcare industry in XML: such applications are open, easy to extend and cost-effective. Additionally, XML is much more than a simple new data interchange format: many proposals for data query (XQL), data presentation (XSL) and other extensions have been proposed to the W3C and partly realised in medical applications.

  19. The role of the microbiome for human health : from basic science to clinical applications

    NARCIS (Netherlands)

    Mohajeri, M Hasan; Brummer, Robert J M; Rastall, Robert A; Weersma, Rinse K; Harmsen, Hermie J M; Faas, Marijke; Eggersdorfer, Manfred

    The 2017 annual symposium organized by the University Medical Center Groningen in The Netherlands focused on the role of the gut microbiome in human health and disease. Experts from academia and industry examined interactions of prebiotics, probiotics, or vitamins with the gut microbiome in health

  20. The role of pancreatic cancer-derived exosomes in cancer progress and their potential application as biomarkers.

    Science.gov (United States)

    Jin, H; Wu, Y; Tan, X

    2017-08-01

    Pancreatic cancer is one of the most deadly cancers, with dismal prognosis due to its poor early detection rate and high metastatic rate. Thus, elucidation of the molecular mechanisms accounting for its metastasis and discovery of competent biomarkers is required. Exosomes are multivesicular body-derived small extracellular vesicles released by various cell types that serve as important message carriers during intercellular communication. They are also known to play critical roles during cancer-genesis, cancer-related immune reactions, and metastasis. They also possess promising potential as novel biomarkers for cancer early detection. Therefore, extensive studies on pancreatic cancer-derived exosomes are currently being performed because they hold the promising potential of elevating the overall survival rate of patients with pancreatic cancer. In the present review, we focus on the role of exosomes in pancreatic cancer-related immune reactions, metastasis, and complications, and on their potential application as pancreatic cancer biomarkers.

  1. Da Lat Nuclear Research Reactor. Role and perspective in the development of radioisotope and nuclear technique application in Vietnam

    International Nuclear Information System (INIS)

    Tran Ha Anh; Tran Khac An; Ngo Phu Khang; Nguyen Mong Sinh

    1995-01-01

    The Da Lat Nuclear Research Reactor is playing a central role in the development of both the Nuclear Research Institute and nuclear application in our country. Thanks to this main scientific tool, the Nuclear Research Institute nearly 10 years after the completion of its renovation from the previous American-made TRIGA MARK 2 reactor is being able to implement numerous scientific and technological research projects and to develop significant applications of radioisotopes and various nuclear techniques. A general overview of the research and development activities of the Institute based on the Da Lat Nuclear Research Reactor is given as well as those aiming at ensuring its safe, reliable and efficient operation and at enlarging the perspectives of its utilisation in the future. (authors). 5 refs., 1 fig., 1 tab

  2. Examination of various roles for covariance matrices in the development, evaluation, and application of nuclear data

    International Nuclear Information System (INIS)

    Smith, D.L.

    1988-01-01

    The last decade has been a period of rapid development in the implementation of covariance-matrix methodology in nuclear data research. This paper offers some perspective on the progress which has been made, on some of the unresolved problems, and on the potential yet to be realized. These discussions address a variety of issues related to the development of nuclear data. Topics examined are: the importance of designing and conducting experiments so that error information is conveniently generated; the procedures for identifying error sources and quantifying their magnitudes and correlations; the combination of errors; the importance of consistent and well-characterized measurement standards; the role of covariances in data parameterization (fitting); the estimation of covariances for values calculated from mathematical models; the identification of abnormalities in covariance matrices and the analysis of their consequences; the problems encountered in representing covariance information in evaluated files; the role of covariances in the weighting of diverse data sets; the comparison of various evaluations; the influence of primary-data covariance in the analysis of covariances for derived quantities (sensitivity); and the role of covariances in the merging of the diverse nuclear data information. 226 refs., 2 tabs

  3. The role of hybrid SPECT-CT in oncology: current and emerging clinical applications

    International Nuclear Information System (INIS)

    Chowdhury, F.U.; Scarsbrook, A.F.

    2008-01-01

    Single photon emission computed tomography - computed tomography (SPECT-CT) is an emerging dual-modality imaging technique with many established and potential clinical applications in the field of oncology. To date, there has been a considerable emphasis on the benefits of integrated positron emission tomography - computed tomography (PET-CT) in oncology, but relatively little focus on the clinical utility of SPECT-CT. As with PET-CT, accurate co-registration of anatomical and functional data from a combined SPECT-CT camera often provides complementary diagnostic information. Both sensitivity (superior disease localization) and specificity (exclusion of false-positives due to physiological tracer uptake) are improved, and the functional significance of indeterminate lesions detected on cross-sectional imaging can be defined. This article will review the scope of hybrid SPECT-CT in oncology and illustrate both current and emerging clinical applications

  4. The Role of Technology in Science Teaching Activities: Web Based Teaching Applications

    OpenAIRE

    Fatma ALKAN; Canan KOÇAK ALTUNDAĞ

    2016-01-01

    2015 Abstract In this research the attitudes of pre-service teachers studying at Hacettepe University, Division of Science Education towards the importance of technological equipment in chemistry education activities and how effective they find technology in teaching different skills and applications have been examined. Pre-test/post-test control group design has been used in the research. In the experimental group Titrimetric Analysis has been conducted with simulations ...

  5. Role of Volatility in the Development of JP-8 Surrogates for Diesel Engine Application

    Science.gov (United States)

    2014-01-01

    rail solenoid injector with a single-hole nozzle is mounted at an angle about 28º from the vertical axis, delivering the fuel into the center of the...the combustion chamber along the axial direction. The first thermocouple measures the charge temperature close by the injector nozzle , and the second...Development of JP-8 Surrogates for Diesel Engine Application Author, co-author (Do NOT enter this information. It will be pulled from participant

  6. Compulsive Internet use: the role of online gaming and other internet applications.

    Science.gov (United States)

    van Rooij, Antonius J; Schoenmakers, Tim M; van de Eijnden, Regina J J M; van de Mheen, Dike

    2010-07-01

    Increasing research on Internet addiction makes it necessary to distinguish between the medium of Internet and its specific applications. This study explores the relationship between time spent on various Internet applications (including online gaming) and Compulsive Internet Use in a large sample of adolescents. The 2007 (N=4,920) and 2008 (N=4,753) samples of a longitudinal survey study among adolescents were used, as well as the 2007-2008 cohort subsample (N=1421). Compulsive Internet Use was predicted from the time spent on the various Internet applications in two cross-sectional multiple linear regression models and one longitudinal regression model in which changes in behavior were related to changes in Compulsive Internet Use. In both samples, downloading, social networking, MSN use, Habbo Hotel, chatting, blogging, online games, and casual games were shown to be associated with Compulsive Internet Use. Off these, online gaming was shown to have the strongest association with Compulsive Internet Use. Moreover, changes in online gaming were most strongly associated with changes in Compulsive Internet Use over time for the longitudinal cohort. A clear relationship was shown between online gaming and Compulsive Internet Use. It is further argued that a subgroup of compulsive Internet users should be classified as compulsive online gamers. Copyright (c) 2010 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

  7. Role of np fertilizer under different application methods on seed yield of sunflower

    International Nuclear Information System (INIS)

    Khan, R.U.; Khan, R.A.; Khan, R.A.; Muendal, H.

    2007-01-01

    The effects of different application methods of nitrogen and phophorus fertilizers were studied on the sunflower hybrid NK-212 during spring and kharif seasons at National Agricultural Research Centre, Islamabad. Nitrogen and phosphorus were applied at the rate 90 and 60 kg P 2 degree 5 ha-1 in a different proportions i.e. all broadcast and disked, 3/4 broadcast disked + 1/4 side banded, 1/2 broadcast disked + 1/2 side banded, 1/4 broadcast disked + 3/4 side banded and all side banded. Fertilizer applied in equal proportions of side banded and broadcast at the time of planting gave maximum (1525 and 1348 kg ha-1) seed yield and largest (14.3 cm and 10.15 cm) head diameter of sunflower in spring seasons during (1987 and 1988), and seed yield of 1206 kg ha-1 and 11.0 cm head diameter during kharif 1987. A significant increase in the 1000 seed weight was also observed in all the treatments receiving different split applications of N and P over all broadcast applied fertilizer. Plant height was not increased by split applications, with lowest height to be associated with most side banding of fertilizers. (author)

  8. Collaborative role construction in a conversation with dementia: an application of systemic functional linguistics.

    Science.gov (United States)

    Müller, Nicole; Wilson, Brent T

    2008-01-01

    This study applies the tools provided by Systemic Functional Linguistics (SFL) to the description of patterns in a conversation between a person with dementia and a person without. It shows how, in the presence of, on the one hand, considerable communicative and cognitive deficits, and on the other, a collaborative interlocutor, a person with dementia succeeds in leading and sustaining a lengthy conversation, and of constructing for himself a positive role in the interaction, namely that of the elder advising a much younger man.

  9. Examining the role of unmeasured confounding in mediation analysis with genetic and genomic applications.

    Science.gov (United States)

    Lutz, Sharon M; Thwing, Annie; Schmiege, Sarah; Kroehl, Miranda; Baker, Christopher D; Starling, Anne P; Hokanson, John E; Ghosh, Debashis

    2017-07-19

    In mediation analysis if unmeasured confounding is present, the estimates for the direct and mediated effects may be over or under estimated. Most methods for the sensitivity analysis of unmeasured confounding in mediation have focused on the mediator-outcome relationship. The Umediation R package enables the user to simulate unmeasured confounding of the exposure-mediator, exposure-outcome, and mediator-outcome relationships in order to see how the results of the mediation analysis would change in the presence of unmeasured confounding. We apply the Umediation package to the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study to examine the role of unmeasured confounding due to population stratification on the effect of a single nucleotide polymorphism (SNP) in the CHRNA5/3/B4 locus on pulmonary function decline as mediated by cigarette smoking. Umediation is a flexible R package that examines the role of unmeasured confounding in mediation analysis allowing for normally distributed or Bernoulli distributed exposures, outcomes, mediators, measured confounders, and unmeasured confounders. Umediation also accommodates multiple measured confounders, multiple unmeasured confounders, and allows for a mediator-exposure interaction on the outcome. Umediation is available as an R package at https://github.com/SharonLutz/Umediation A tutorial on how to install and use the Umediation package is available in the Additional file 1.

  10. The Role of Suomi NPP VIIRS Data in Land Science and Applications.

    Science.gov (United States)

    Justice, C. O.; Csiszar, I. A.; Roman, M. O.; Vermote, E.

    2014-12-01

    The current Suomi-NPP mission was designed as a bridging mission to the Joint Polar Satellite System (JPSS) next-generation, operational satellites. The VIIRS instrument on-board Suomi-NPP provides continuity with NASA's Earth Observing System Moderate-resolution Imaging Spectroradiometer (MODIS) observations and a much-needed replacement of the long-serving, operational NOAA Advanced Very High Resolution Radiometer (AVHRR) system, to meet the expanding needs of Earth Science and Applications of Societal Benefit. Post-launch evaluation has proven the instrument to be excellent for land observations and capable of providing measurement continuity with MODIS. This provides a critical contribution to the scientific study of global change. Several regions of the World are undergoing rapid land transformations, driven by economic development and population growth. In addition, changes in climate conditions are resulting in ecosystem responses and changes in land cover and land use. Long-term, systematic observations of the global land surface at coarse resolution enable detection, monitoring and characterization of such changes to the land surface. A suite of Land environmental data records (EDRs) from the VIIRS, are being developed by NOAA to meet operational data needs, primarily for the National Weather Service (e.g., Albedo, Land Surface Temperature, Fractional Vegetation Cover, Surface Type, Snow and Ice Monitoring). Scientists funded by NOAA and NASA, have been evaluating and validating these products. Based on these evaluations, NASA is embarking on a program to develop enhanced and additional products to provide continuity with MODIS to meet the needs of the global change science community. In addition, and as with MODIS, data from the VIIRS can be used as input to a number of practical applications of societal benefit and the associated decision support systems. For example, progress with VIIRS data is being made in the areas of fire and agricultural monitoring

  11. What is the role of curvature on the properties of nanomaterials for biomedical applications?

    Science.gov (United States)

    Gonzalez Solveyra, Estefania; Szleifer, Igal

    2016-05-01

    The use of nanomaterials for drug delivery and theranostics applications is a promising paradigm in nanomedicine, as it brings together the best features of nanotechnolgy, molecular biology, and medicine. To fully exploit the synergistic potential of such interdisciplinary strategy, a comprehensive description of the interactions at the interface between nanomaterials and biological systems is not only crucial, but also mandatory. Routine strategies to engineer nanomaterial-based drugs comprise modifying their surface with biocompatible and targeting ligands, in many cases resorting to modular approaches that assume additive behavior. However, emergent behavior can be observed when combining confinement and curvature. The final properties of functionalized nanomaterials become dependent not only on the properties of their constituents but also on the geometry of the nano-bio interface, and on the local molecular environment. Modularity no longer holds, and the coupling between interactions, chemical equilibrium, and molecular organization has to be directly addressed in order to design smart nanomaterials with controlled spatial functionalization envisioning optimized biomedical applications. Nanoparticle's curvature becomes an integral part of the design strategy, enabling to control and engineer the chemical and surface properties with molecular precision. Understanding how nanoparticle size, morphology, and surface chemistry are interrelated will put us one step closer to engineering nanobiomaterials capable of mimicking biological structures and their behaviors, paving the way into applications and the possibility to elucidate the use of curvature by biological systems. WIREs Nanomed Nanobiotechnol 2016, 8:334-354. doi: 10.1002/wnan.1365 For further resources related to this article, please visit the WIREs website. © 2015 Wiley Periodicals, Inc.

  12. Synthesis of SWNT/Pt nanocomposites for their effective role in hydrogen storage applications

    Science.gov (United States)

    Sharma, Anshu; Andreas, Rossos; Nehra, S. P.

    2018-05-01

    Single Wall Carbon Nanotubes (SWNTs) decorated with platinum were synthesized for hydrogen storage applications. Platinum was deposited on the nanotubes using hexachloroplatinic acid (H2PtCl6.6H2O) as a precursor. Commercial SWNTs were also used to compare the results. The obtained SWNTs/Pt nanocomposite was characterized by various techniques such as powder X-ray diffractrometry (XRD), Raman Spectroscopy and Scanning Electron Microscopy (SEM). Furthermore, in the case of SWNTs/Pt, Pt nanoparticles are found to be uniformly dispersed and bound to the SWNTs acting like a single atom catalyst.

  13. The Emerging Role of Tractography in Deep Brain Stimulation: Basic Principles and Current Applications

    Directory of Open Access Journals (Sweden)

    Nelson B. Rodrigues

    2018-01-01

    Full Text Available Diffusion tensor imaging (DTI is an MRI-based technique that delineates white matter tracts in the brain by tracking the diffusion of water in neural tissue. This methodology, known as “tractography”, has been extensively applied in clinical neuroscience to explore nervous system architecture and diseases. More recently, tractography has been used to assist with neurosurgical targeting in functional neurosurgery. This review provides an overview of DTI principles, and discusses current applications of tractography for improving and helping develop novel deep brain stimulation (DBS targets.

  14. The role of soil in NBT applications to landmine detection problem

    International Nuclear Information System (INIS)

    Obhodas, Jasmina; Sudac, Davorin; Nad, Karlo; Valkovic, Vlado; Nebbia, Giancarlo; Viesti, Giuseppe

    2003-01-01

    Long-term observations of soil water content as well as determination of physical and chemical properties of different types of soils in Croatia were made in order to provide the necessary background information for landmine explosive detection. Soil water content is the key attribute of soil as a background in neutron backscattering technique (NBT) landmine detection application. If the critical value of the soil water content is reached, the detection of landmine explosives is not possible. It is recommended that soil moisture content for NBT application does not exceed 0.1 kg.kg-1 [1]. Nineteen representative samples of different soil types from different parts of Croatia were collected in order to establish soil bank with the necessary physical and chemical properties determined for each type of soil. In addition soil water content was measured on daily and weekly basis on several locations in Croatia. This procedure also included daily soil moisture measurements in the test field made of different types of soils from several locations in Croatia. This was done in order to evaluate the behavior of different types of soils under the same weather conditions

  15. The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine

    DEFF Research Database (Denmark)

    Andersen, Morten Østergaard; Dillschneider, Philipp; Kjems, Jørgen

    2013-01-01

    to specifically target tissue engineering and repair, either in culture or in association with implanted cells and/or implants. We will here summarise these methods providing examples from present literature. Based on previous results, we will also predict more advanced technologies that may deliver mi......Many cellular functions rely on the coordinated expression and repression of a large number of messenger RNAs; these are tightly controlled in part by microRNAs (miRNAs) at the posttranscriptional level. The number of characterised miRNAs that are involved in tissue development and repair...... will revolutionise regenerative medicine. This chapter will introduce miRNA biology and their role in controlling pluripotency, stem cell differentiation, proliferation, senescence, survival, inflammation and angiogenesis. There are several strategies by which miRNA-modulating technologies can be used...

  16. The Role of Organizations in Liberation Psychology: Applications to the Study of Migrations

    Directory of Open Access Journals (Sweden)

    Virginia Paloma

    2011-11-01

    Full Text Available The incorporation of an immigrant population in the receiving society often takes place in the context of asymmetrical power relationships between immigrants and other groups in society. This often reduces the chances of successfully fulfilling any goals or plans that immigrants may have for their lives in the new country. In this paper we analyze how the study of migration can be enriched by Liberation Psychology, a theoretical approach which calls for the transformation of society at all levels (structural, organizational and individual as a means to create social justice and conditions of well-being for all social groups. In addition, we analyze how the internal dynamics of several organizations working in the field of migration are actually helping to perpetuate the status quo. Finally, we highlight the potential role that organizations can play in the construction of a just multicultural society, using a Liberation Psychology approach.

  17. Application of differential game theory to role-determination in aerial combat

    Science.gov (United States)

    Merz, A. W.

    1975-01-01

    The development of criteria which specify the roles of pursuer and evader as functions of the relative geometry and of the important parameters of the problem are discussed. A reduced-order model of the relative motion is derived and discussed. In this model, the two aircraft move in the same plane at unequal but constant speeds, and with different maximum turn rates. The equations of relative motion are of third order, the dependent variables being the relative range, bearing, and heading of the two aircraft. Termination of the pursuit-evasion game is defined by either the heading-limited or the range-limited end condition. These are geometric conditions for which the evading aircraft is in front of the other, with the relative heading and relative range satisfying certain inequalities. Retrograde solutions to the equations of relative motion were used with the derived optimal terminal maneuvers to find where an assumed set of end conditions could have begun.

  18. The Role and Potential Therapeutic Application of Myeloid-Derived Suppressor Cells in Allo- and Autoimmunity

    Directory of Open Access Journals (Sweden)

    Qi Zhang

    2015-01-01

    Full Text Available Myeloid-derived suppressor cells (MDSCs are a heterogeneous population of cells that consists of myeloid progenitor cells and immature myeloid cells. They have been identified as a cell population that may affect the activation of CD4+ and CD8+ T-cells to regulate the immune response negatively, which makes them attractive targets for the treatment of transplantation and autoimmune diseases. Several studies have suggested the potential suppressive effect of MDSCs on allo- and autoimmune responses. Conversely, MDSCs have also been found at various stages of differentiation, accumulating during pathological situations, not only during tumor development but also in a variety of inflammatory immune responses, bone marrow transplantation, and some autoimmune diseases. These findings appear to be contradictory. In this review, we summarize the roles of MDSCs in different transplantation and autoimmune diseases models as well as the potential to target these cells for therapeutic benefit.

  19. Emerging roles of exosomes in normal and pathological conditions. New insights for diagnosis and therapeutic applications

    Directory of Open Access Journals (Sweden)

    Julieta eDe Toro

    2015-05-01

    Full Text Available From the time when they were first described in the 1970s by the group of Johnstone and Stahl, exosomes are a target of constant research. Exosomes belong to the family of nano-vesicles which are of great interest for their many functions and potential for diagnosis and therapy in multiples diseases. Exosomes originate from the intraluminal vesicles of late endosomal compartments named multivesicular bodies and the fusion of these late endosomes with the cell membrane result in the release of the vesicles into the extracellular compartment. Moreover, their generation can be induced by many factors including extracellular stimuli, such as microbial attack and other stress conditions. The primary role attributed to exosomes was the removal of unnecessary proteins from the cells. Now, several studies have demonstrated that exosomes are involved in cell-cell communication, even though their biological function is not completely clear.The participation of exosomes in cancer is the field of microvesicle research that has expanded more over the last years. Evidence proving that exosomes derived from tumor-pulsed dendritic cells, neoplastic cells and malignant effusions, are able to present antigens to T‐cells, has led to numerous studies using them as cell free cancer vaccines.Since exosomes derive from all cell types, they contain proteins, lipids and miRNA capable of regulating a variety of target genes. Much research is being conducted, which focuses on the employment of these vesicles as biomarkers in the diagnosis of cancer in addition to innovative biomarkers for diagnosis, prognosis and management of cardiovascular diseases. Interesting findings indicating the role of exosomes in the pathogenesis of several diseases have encouraged researchers to consider their therapeutic potential not only in oncology but also in the treatment of autoimmune syndromes and neurodegenerative disorders such as Alzheimer´s and Parkinson´s disease; in addition

  20. Social Media Used by Government Institutions in Iceland: Application, Role and Aims

    Directory of Open Access Journals (Sweden)

    Már Einarsson

    2014-12-01

    Full Text Available The purpose of this research was to study the use and role of social media hosted by government institutions in Iceland. The research was conducted using quantitative and qualitative research methods. A survey was sent electronically to all government institutions in Iceland and semi-structured interviews were conducted with specialists working for institutions. No research has been conducted on this subject in Iceland before. It was therefore considered timely that a research was conducted on the use of social media in public institutions, with the intention of adding new knowledge to the field. No similar research from outside of Iceland was found, but this research was based on related studies and sources from abroad. A little less than half of government institutions used social media as part of their activities and Facebook and YouTube were most widely used. Popularity, circulation, usefulness and convenience were the most important factors when choosing social media. The majority of institutions had neither defined social media goals nor the role and responsibility of employees when using social media. The institutions placed strong emphasis on publishing adverts and news items on the institutions’ activities via social media pages and there were a considerable number of references to material on other web pages. Among other things the interviewees said that the purpose of using social media was information dissemination, reception of information, more visibility, the opening of institutions to the public and increased transparency. They talked about the importance of being informal on social media, but they also pointed out that there had been some fear among institutions of using them, in particular fear of employees showing a human side via social media. There was minimal use of original material on institutions’ social media pages, while institutions were quite systematic in posting material from their website through social media

  1. The Role of Retinal Imaging and Portable Screening Devices in Tele-ophthalmology Applications for Diabetic Retinopathy Management.

    Science.gov (United States)

    DeBuc, Delia Cabrera

    2016-12-01

    In the years since its introduction, retinal imaging has transformed our capability to visualize the posterior pole of the eye. Increasing practical advances in mobile technology, regular monitoring, and population screening for diabetic retinopathy management offer the opportunity for further development of cost-effective applications through remote assessment of the diabetic eye using portable retinal cameras, smart-phone-based devices and telemedicine networks. Numerous retinal imaging methods and mobile technologies in tele-ophthalmology applications have been reported for diabetic retinopathy screening and management. They provide several advantages of automation, sensitivity, specificity, portability, and miniaturization for the development of point-of-care diagnostics for eye complications in diabetes. The aim of this paper is to review the role of retinal imaging and mobile technologies in tele-ophthalmology applications for diabetic retinopathy screening and management. At large, although improvements in current technology and telemedicine services are still needed, telemedicine has demonstrated to be a worthy tool to support health caregivers in the effective management and prevention of diabetes and its complications.

  2. Exposure to organophosphate flame retardants in spray polyurethane foam applicators: Role of dermal exposure.

    Science.gov (United States)

    Bello, Anila; Carignan, Courtney C; Xue, Yalong; Stapleton, Heather M; Bello, Dhimiter

    2018-04-01

    Spray polyurethane foam (SPF) is a highly effective thermal insulation material that has seen considerable market growth in the past decade. Organophosphate flame retardants (PFRs) are added to SPF formulations to meet fire code requirements. A common flame retardant used in SPF formulations is tris 1-chloro 2-propyl phosphate (TCIPP), a suspected endocrine disruptor. Exposure monitoring efforts during SPF applications have focused primarily on the isocyanate component, a potent respiratory and dermal sensitizer. However, to our knowledge, there is no monitoring data for TCIPP. To characterize occupational exposures to TCIPP and other flame retardants during SPF insulation. Workers at four SPF insulation sites and one foam removal site (total n = 14) were recruited as part of this pilot study. Personal inhalation exposure to TCIPP was monitored with a CIP-10MI inhalable sampler and potential dermal exposure was assessed through the use of a glove dosimeter. Biomarkers of TCIPP and three other PFRs were measured in urine collected from workers pre-and post-shift. Linear mixed effect models were used to analyze associations of urinary biomarkers with inhalation and dermal exposures and paired t-tests were used to examine the difference on the means of urinary biomarkers pre-and post-shift. Chemical analysis of all species was performed with liquid chromatography-electrospray ionization tandem mass spectrometry. Geometric mean (GM) concentrations of TCIPP in personal air monitors and glove dosimeters collected from SPF applicators, 294.7 μg/m 3 and 18.8 mg/pair respectively. Overall, GM concentrations of the two TCIPP urinary biomarkers BCIPP and BCIPHIPP and (6.2 and 88.8 μg/mL) were 26-35 times higher than reported in the general population. Post-shift levels of TCIPP biomarkers were higher than pre-shift even though workers at insulation sites wore supplied air respirators, gloves and coveralls. The urinary biomarkers for the other PFRs were not

  3. Perspective of Fe3O4 Nanoparticles Role in Biomedical Applications

    Science.gov (United States)

    Kashefi, Mehrdad; Shams, Seyyedeh Fatemeh; Jaafari, Mahmoud Reza

    2016-01-01

    In recent years, although many review articles have been presented about bioapplications of magnetic nanoparticles by some research groups with different expertise such as chemistry, biology, medicine, pharmacology, and materials science and engineering, the majority of these reviews are insufficiently comprehensive in all related topics like magnetic aspects of process. In the current review, it is attempted to carry out the inclusive surveys on importance of magnetic nanoparticles and especially magnetite ones and their required conditions for appropriate performance in bioapplications. The main attentions of this paper are focused on magnetic features which are less considered. Accordingly, the review contains essential magnetic properties and their measurement methods, synthesis techniques, surface modification processes, and applications of magnetic nanoparticles. PMID:27293893

  4. The role of driver nodes in managing epileptic seizures: Application of Kuramoto model.

    Science.gov (United States)

    Mohseni, Ali; Gharibzadeh, Shahriar; Bakouie, Fatemeh

    2017-04-21

    Synchronization is an important global phenomenon which could be found in a wide range of complex systems such as brain or electronic devices. However, in some circumstances the synchronized states are not desirable for the system and should be suppressed. For example, excessively synchronized activities in the brain network could be the root of neuronal disorders like epileptic seizures. According to the controllability theory of the complex networks, a minimum set of driver nodes has the ability to control the entire system. In this study, we examine the role of driver nodes in suppressing the excessive synchronization in a generalized Kuramoto model, which consists of two types of oscillators: contrarian and regular ones. We used two different structural topologies: Barabási-Albert scale-free (BASF) network and Caenorhabditis elegans (C.elegans) neuronal network. Our results show that contrarian driver nodes have the sufficient ability to break the synchronized level of the systems. In this case, the system coherency level is not fully suppressed that is avoiding dysfunctions of normal brain functions which require the neuronal synchronized activities. Moreover, in this case, the oscillators grouped in two distinct synchronized clusters that could be an indication of chaotic behavior of the system known as resting-state activity of the brain. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Influence of saturation degree and role of suction in unsaturated soils behaviour: application to liquefaction

    Directory of Open Access Journals (Sweden)

    Vernay Mathilde

    2016-01-01

    Full Text Available The effect of the pore fluid compressibility on liquefaction has been studied by various authors. But few papers have been published about the role of suction in cyclic behavior of unsaturated soils. Most of these works use Skempton coefficient B as a reference in terms of saturation degree to analyze their results. The use of B in experimental conditions is convenient, but is not accurate when studying liquefaction behavior, since effects of suction are neglected. In this paper, the influence of saturation degree on mechanical behavior of a soil under dynamic loads is studied. Cyclic undrained triaxial tests were performed on sand samples, under various levels of saturation. Soil-water characteristic curve was used, in order to study influence of suction. The first results confirm that when the degree of saturation decreases, the resistance increases. Initial positive suction tends to stiffen the soil. It also appears that the presence of air delays the occurrence of liquefaction, but doesn’t prevent it. Indeed, liquefaction is observed, whether the soil is saturated or not.

  6. Aluminum stress and its role in the phospholipid signaling pathway in plants and possible biotechnological applications.

    Science.gov (United States)

    Poot-Poot, Wilberth; Hernandez-Sotomayor, Soledad M Teresa

    2011-10-01

    An early response of plants to environmental signals or abiotic stress suggests that the phospholipid signaling pathway plays a pivotal role in these mechanisms. The phospholipid signaling cascade is one of the main systems of cellular transduction and is related to other signal transduction mechanisms. These other mechanisms include the generation of second messengers and their interactions with various proteins, such as ion channels. This phospholipid signaling cascade is activated by changes in the environment, such as phosphate starvation, water, metals, saline stres, and plant-pathogen interactions. One important factor that impacts agricultural crops is metal-induced stress. Because aluminum has been considered to be a major toxic factor for agriculture conducted in acidic soils, many researchers have focused on understanding the mechanisms of aluminum toxicity in plants. We have contributed the last fifteen years in this field by studying the effects of aluminum on phospholipid signaling in coffee, one of the Mexico's primary crops. We have focused our research on aluminum toxicity mechanisms in Coffea arabica suspension cells as a model for developing future contributions to the biotechnological transformation of coffee crops such that they can be made resistant to aluminum toxicity. We conclude that aluminum is able to not only generate a signal cascade in plants but also modulate other signal cascades generated by other types of stress in plants. The aim of this review is to discuss possible involvement of the phospholipid signaling pathway in the aluminum toxicity response of plant cells. Copyright © 2011 Wiley Periodicals, Inc.

  7. Exopolysaccharides from Marine and Marine Extremophilic Bacteria: Structures, Properties, Ecological Roles and Applications

    Directory of Open Access Journals (Sweden)

    Angela Casillo

    2018-02-01

    Full Text Available The marine environment is the largest aquatic ecosystem on Earth and it harbours microorganisms responsible for more than 50% of total biomass of prokaryotes in the world. All these microorganisms produce extracellular polymers that constitute a substantial part of the dissolved organic carbon, often in the form of exopolysaccharides (EPS. In addition, the production of these polymers is often correlated to the establishment of the biofilm growth mode, during which they are important matrix components. Their functions include adhesion and colonization of surfaces, protection of the bacterial cells and support for biochemical interactions between the bacteria and the surrounding environment. The aim of this review is to present a summary of the status of the research about the structures of exopolysaccharides from marine bacteria, including capsular, medium released and biofilm embedded polysaccharides. Moreover, ecological roles of these polymers, especially for those isolated from extreme ecological niches (deep-sea hydrothermal vents, polar regions, hypersaline ponds, etc., are reported. Finally, relationships between the structure and the function of the exopolysaccharides are discussed.

  8. Moving research to patient applications through commercialization: understanding and evaluating the role of intellectual property.

    Science.gov (United States)

    Patino, Robert M

    2010-03-01

    The advancement of research from discovery to the delivery of medical care can be limited without the support of industry to sponsor its continued development. Federal government financial support is generally crucial in early-stage development through funding from the NIH, National Science Foundation, and other federal agencies; however, government support generally stops shortly after basic research discoveries have been reported. Much of the cessation of financial support derives from the government's regulatory responsibilities, as sponsoring the commercialization of a product conflicts with regulation of the approval for clinical use of a drug or device. Furthermore, differences in goals, resources, and flexibility render government, as compared with private industry, inefficient and less responsive to market demands with regard to stream-lining the development of and enhancing the quality of products and services offered. Thus, industry and private investment provide the bridge that converts new discoveries into healthcare products that are available to consumers and patients. This conversion occurs through commercialization, which involves both high risks and high rewards. Taking advantage of the commercialization option for research development requires an understanding of the technology transfer process. This article reviews 5 topics: 1) industry motivation to invest in academic research; 2) institutional considerations in partnering with industry; 3) academia's interactions with inventors in the commercialization process; 4) the research institution's route to commercialization, and 5) the role of intellectual property and commercialization in the advancement of healthcare.

  9. Characterization of diatomite and its application for the retention of radiocobalt: role of environmental parameters

    International Nuclear Information System (INIS)

    Sheng, Guodong; Dong, Huaping; Li, Yimin

    2012-01-01

    Clay minerals have been extensively studied because of their strong sorption and complexation ability. In this work, diatomite was characterized by using acid–base titration. Retention of radionuclide 60 Co(II) from aqueous solution by sorption onto diatomite was investigated by using batch technique under various environmental conditions such as pH, ionic strength, humic acid (HA), fulvic acid (FA), and temperature. The results indicated that the sorption of Co(II) onto diatomite was strongly dependent on pH. At low pH value, the sorption of Co(II) was dominated by outer-sphere surface complexation and ion exchange with Na + /H + on diatomite surfaces, whereas inner-sphere surface complexation was the main sorption mechanism at high pH value. The D–R model fitted the sorption isotherms better than the Langmuir and Freundlich models. The thermodynamic parameters (ΔH 0 , ΔS 0 and ΔG 0 ) calculated from the temperature-dependent sorption isotherms suggested that the sorption of Co(II) was an endothermic and spontaneous process. In addition, diatomite showed higher sorption capacity than that of lots of the sorbents reported in the literatures we surveyed. From the results of Co(II) removal by diatomite, the optimum reaction conditions can be obtained for the maximum removal of Co(II) from water. It is clear that the best pH values of the system to remove Co(II) from solution by using diatomite are 7–8. Considering the low cost and effective disposal of Co(II)-contaminated wastewaters, the best condition for Co(II) removal is at room temperature and solid content of 0.5 g/L. The results might be important for assessing the potential of practical application of diatomite in Co(II) and related radionuclide pollution management. - Highlights: ► The sorption of Co(II) was strongly dependent on ionic strength at low pH, but independent of ionic strength at high pH. ► A positive effect of HA/FA on Co(II) sorption was found at low pH, whereas a negative effect

  10. Enhanced Deployment Strategy for Role-based Hierarchical Application Agents in Wireless Sensor Networks with Established Clusterheads

    Science.gov (United States)

    Gendreau, Audrey

    Efficient self-organizing virtual clusterheads that supervise data collection based on their wireless connectivity, risk, and overhead costs, are an important element of Wireless Sensor Networks (WSNs). This function is especially critical during deployment when system resources are allocated to a subsequent application. In the presented research, a model used to deploy intrusion detection capability on a Local Area Network (LAN), in the literature, was extended to develop a role-based hierarchical agent deployment algorithm for a WSN. The resulting model took into consideration the monitoring capability, risk, deployment distribution cost, and monitoring cost associated with each node. Changing the original LAN methodology approach to model a cluster-based sensor network depended on the ability to duplicate a specific parameter that represented the monitoring capability. Furthermore, other parameters derived from a LAN can elevate costs and risk of deployment, as well as jeopardize the success of an application on a WSN. A key component of the approach presented in this research was to reduce the costs when established clusterheads in the network were found to be capable of hosting additional detection agents. In addition, another cost savings component of the study addressed the reduction of vulnerabilities associated with deployment of agents to high volume nodes. The effectiveness of the presented method was validated by comparing it against a type of a power-based scheme that used each node's remaining energy as the deployment value. While available energy is directly related to the model used in the presented method, the study deliberately sought out nodes that were identified with having superior monitoring capability, cost less to create and sustain, and are at low-risk of an attack. This work investigated improving the efficiency of an intrusion detection system (IDS) by using the proposed model to deploy monitoring agents after a temperature sensing

  11. Influence of Nanotechnology and the Role of Nanostructures in Biomimetic Studies and Their Potential Applications

    Directory of Open Access Journals (Sweden)

    Puneet Garg

    2017-05-01

    Full Text Available With the advent of nanotechnology, by looking further deep down into the molecular level, today, we are able to understand basic and applied sciences even better than ever before. Not only has nanoscience and nanotechnology allowed us to study the composing structures of materials in detail, it has also allowed us to fabricate and synthesize such nanostructures using top-down and bottom-up approaches. One such field, which has been significantly influenced by the dawn of nanotechnology is biomimetics. With powerful spectroscopic and microscopic tools presenting us with images like double nanostructured pillars on the lotus surface for superhydrophobicity, the conical protuberances of moth eye demonstrating anti-reflection properties and nanostructured spatulae of gecko feet for high adhesivity, we are now able to fabricate these structures in the lab with properties showing close resemblance to their natural counterparts. Here, we present a review of various nanostructures that exist in nature, their fabrication techniques and some of their promising future applications. We hope this review will provide the reader with a basic understanding of what biomimetics is and how nanotechnology has significantly influenced this field.

  12. NiTi Alloys for Tribological Applications: The Role of In-Situ Nanotechnology

    Science.gov (United States)

    Dellacorte, Christopher

    2016-01-01

    Beginning in 2004, NASA initiated the investigation and development of, Nitinol 60, a nickel-rich and dimensionally stable version of shape memory alloy Nitinol 55, as an alternative to bearing steel. Early investigations showed it to be hard and impervious to aqueous corrosion but the fundamental reasons for these properties were unknown. Shape memory alloys made from equiatomic Ni-Ti are widely known for their unique dimensional instability behavior that can be triggered by thermal and mechanical stress. The nickel-rich alloys exhibit no such dimension change property and have high hardness but have largely been overlooked by industry and the engineering community. Though steel is the dominant material of choice for mechanical components (bearings and gears) it has intrinsic limitations related to corrosion and plastic deformation. In contrast, Ni-Ti alloys are intrinsically rustproof and can withstand high contact loads without damage (denting). Over the last decade, focused RD to exploit these alloys for new applications has revealed that in-situ nano-scale phases that form during processing are largely responsible for NiTis remarkable properties. In this presentation, the state-of-art of nickel-rich NiTi alloys will be introduced and the nanotechnology behind their intriguing behavior will be addressed. The presentation will include discussion of how NASA is adopting this new technology inside the space station water recycling system as a pathfinder for more down-to-earth tribological challenges.

  13. The advantage of being oneself: The role of applicant self-verification in organizational hiring decisions.

    Science.gov (United States)

    Moore, Celia; Lee, Sun Young; Kim, Kawon; Cable, Daniel M

    2017-11-01

    In this paper, we explore whether individuals who strive to self-verify flourish or flounder on the job market. Using placement data from 2 very different field samples, we found that individuals rated by the organization as being in the top 10% of candidates were significantly more likely to receive a job offer if they have a stronger drive to self-verify. A third study, using a quasi-experimental design, explored the mechanism behind this effect and tested whether individuals who are high and low on this disposition communicate differently in a structured mock job interview. Text analysis (LIWC) of interview transcripts revealed systematic differences in candidates' language use as a function of their self-verification drives. These differences led an expert rater to perceive candidates with a strong drive to self-verify as less inauthentic and less misrepresentative than their low self-verifying peers, making her more likely to recommend these candidates for a job. Taken together, our results suggest that authentic self-presentation is an unidentified route to success on the job market, amplifying the chances that high-quality candidates can convert organizations' positive evaluations into tangible job offers. We discuss implications for job applicants, organizations, and the labor market. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  14. Translating Knowledge: The role of Shared Learning in Bridging the Science-Application Divide

    Science.gov (United States)

    Moench, M.

    2014-12-01

    As the organizers of this session state: "Understanding and managing our future relation with the Earth requires research and knowledge spanning diverse fields, and integrated, societally-relevant science that is geared toward solutions." In most cases, however, integration is weak and scientific outputs do not match decision maker requirements. As a result, while scientific results may be highly relevant to society that relevance is operationally far from clear. This paper explores the use of shared learning processes to bridge the gap between the evolving body of scientific information on climate change and its relevance for resilience planning in cities across Asia. Examples related to understanding uncertainty, the evolution of scientific knowledge from different sources, and data extraction and presentation are given using experiences generated over five years of work as part of the Rockefeller Foundation supported Asian Cities Climate Change Resilience Network and other programs. Results suggest that processes supporting effective translation of knowledge between different sources and different applications are essential for the identification of solutions that respond to the dynamics and uncertainties inherent in global change processes.

  15. Waste Derived Sorbents and Their Potential Roles in Heavy Metal Remediation Applications

    Directory of Open Access Journals (Sweden)

    Chiang Y. W.

    2013-04-01

    Full Text Available Inorganic waste materials that have the suitable inherent characteristics could be used as precursors for the synthesis of micro- and mesoporous materials, which present great potential to be re-utilized as sorbent materials for heavy metal remediation. Three inorganic waste materials were studied in the present work: water treatment residuals (WTRs from an integrated drinking water/wastewater treatment plant, and fly ash and bottom ash samples from a municipal solid waste incinerator (MSWI. These wastes were converted into three sorbent materials: ferrihydrite-like materials derived from drying of WTRs, hydroxyapatite-like material derived from ultrasound assisted synthesis of MSWI fly ash with phosphoric acid solution, and a zeolitic material derived from alkaline hydrothermal conversion of MSWI bottom ash. The performance of these materials, as well as their equivalent commercially available counterparts, was assessed for the adsorption of multiple heavy metals (As, Cd, Co, Ni, Pb, Zn from synthetic solutions, contaminated sediments and surface waters; and satisfactory results were obtained. In addition, it was observed that the combination of sorbents into sorbent mixtures enhanced the performance levels and, where applicable, stabilized inherently mobile contaminants from the waste derived sorbents.

  16. [Role and management of cancer clinical database in the application of gastric cancer precision medicine].

    Science.gov (United States)

    Li, Yuanfang; Zhou, Zhiwei

    2016-02-01

    Precision medicine is a new medical concept and medical model, which is based on personalized medicine, rapid progress of genome sequencing technology and cross application of biological information and big data science. Precision medicine improves the diagnosis and treatment of gastric cancer to provide more convenience through more profound analyses of characteristics, pathogenesis and other core issues in gastric cancer. Cancer clinical database is important to promote the development of precision medicine. Therefore, it is necessary to pay close attention to the construction and management of the database. The clinical database of Sun Yat-sen University Cancer Center is composed of medical record database, blood specimen bank, tissue bank and medical imaging database. In order to ensure the good quality of the database, the design and management of the database should follow the strict standard operation procedure(SOP) model. Data sharing is an important way to improve medical research in the era of medical big data. The construction and management of clinical database must also be strengthened and innovated.

  17. Animal models in genomic research: Techniques, applications, and roles for nurses.

    Science.gov (United States)

    Osier, Nicole D; Pham, Lan; Savarese, Amanda; Sayles, Kendra; Alexander, Sheila A

    2016-11-01

    Animal research has been conducted by scientists for over two millennia resulting in a better understanding of human anatomy, physiology, and pathology, as well as testing of novel therapies. In the molecular genomic era, pre-clinical models represent a key tool for understanding the genomic underpinnings of health and disease and are relevant to precision medicine initiatives. Nurses contribute to improved health by collecting and translating evidence from clinically relevant pre-clinical models. Using animal models, nurses can ask questions that would not be feasible or ethical to address in humans, and establish the safety and efficacy of interventions before translating them to clinical trials. Two advantages of using pre-clinical models are reduced variability between test subjects and the opportunity for precisely controlled experimental exposures. Standardized care controls the effects of diet and environment, while the availability of inbred strains significantly reduces the confounding effects of genetic differences. Outside the laboratory, nurses can contribute to the approval and oversight of animal studies, as well as translation to clinical trials and, ultimately, patient care. This review is intended as a primer on the use of animal models to advance nursing science; specifically, the paper discusses the utility of preclinical models for studying the pathophysiologic and genomic contributors to health and disease, testing interventions, and evaluating effects of environmental exposures. Considerations specifically geared to nurse researchers are also introduced, including discussion of how to choose an appropriate model and controls, potential confounders, as well as legal and ethical concerns. Finally, roles for nurse clinicians in pre-clinical research are also highlighted. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Improving adherence to acne treatment: the emerging role of application software

    Directory of Open Access Journals (Sweden)

    Park C

    2014-02-01

    Full Text Available Chanhyun Park,1 Gilwan Kim,1 Isha Patel,2 Jongwha Chang,3 Xi Tan2 1College of Pharmacy, University of Texas at Austin, Austin, TX, USA; 2College of Pharmacy, University of Michigan, Ann Arbor, MI, USA; 3McWhorter School of Pharmacy, Samford University, Birmingham, AL, USA Objective: To examine recent studies on the effect of mobile and electronic (ME-health technology on adherence to acne treatment. Background: With emerging use of ME-health technology, there is a growing interest in evaluating the effectiveness of the tools on medication adherence. Examples of ME-health technology-based tools include text message-based pill reminders and Web-based patient education. Methods: MEDLINE, Cochrane Library, and Web of Science were searched for articles on adherence to acne treatment published through November 2013. A combination of search terms such as "acne" and "adherence" or "compliance" were used. Results: Adherence to oral acne medication was higher than for topical acne medication. The frequency of office visits was also an influencing factor for acne treatment adherence. The telephone-based reminders on a daily basis did not improve acne patients' medication adherence, whereas the Web-based educational tools on a weekly basis had a positive effect on medication adherence in acne treatment. Conclusion: In using ME-health interventions, factors such as medication dosage forms, frequency of intervention, and patients' preferences should be taken into consideration. Developing disease-specific text message reminders may be helpful to increase adherence rates. In addition, a combination of text message reminders with another type of intervention may improve medication adherence. Keywords: acne vulgaris, medication adherence, compliance, mobile and electronic health technology, application software, telemedicine

  19. Role of data aggregation in biosurveillance detection strategies with applications from ESSENCE.

    Science.gov (United States)

    Burkom, Howard S; Elbert, Y; Feldman, A; Lin, J

    2004-09-24

    Syndromic surveillance systems are used to monitor daily electronic data streams for anomalous counts of features of varying specificity. The monitored quantities might be counts of clinical diagnoses, sales of over-the-counter influenza remedies, school absenteeism among a given age group, and so forth. Basic data-aggregation decisions for these systems include determining which records to count and how to group them in space and time. This paper discusses the application of spatial and temporal data-aggregation strategies for multiple data streams to alerting algorithms appropriate to the surveillance region and public health threat of interest. Such a strategy was applied and evaluated for a complex, authentic, multisource, multiregion environment, including >2 years of data records from a system-evaluation exercise for the Defense Advanced Research Project Agency (DARPA). Multivariate and multiple univariate statistical process control methods were adapted and applied to the DARPA data collection. Comparative parametric analyses based on temporal aggregation were used to optimize the performance of these algorithms for timely detection of a set of outbreaks identified in the data by a team of epidemiologists. The sensitivity and timeliness of the most promising detection methods were tested at empirically calculated thresholds corresponding to multiple practical false-alert rates. Even at the strictest false-alert rate, all but one of the outbreaks were detected by the best method, and the best methods achieved a 1-day median time before alert over the set of test outbreaks. These results indicate that a biosurveillance system can provide a substantial alerting-timeliness advantage over traditional public health monitoring for certain outbreaks. Comparative analyses of individual algorithm results indicate further achievable improvement in sensitivity and specificity.

  20. The role of risk management in corporate governance: Guidelines and applications

    Directory of Open Access Journals (Sweden)

    Hugh Grove

    2017-11-01

    Full Text Available Risk management should be a key concern of board members to enhance corporate governance in any organization. Eleven key numbers, ratios, and models were advocated in this paper for risk management analyses, including an analysis of their variability with graphs. They are applied to Kaisa, a Chinese property developer, located in Shenzhen but incorporated with limited liability in the Cayman Islands. The importance of such risk management analyses was demonstrated in this paper as Kaisa destroyed $12.9 billion in four different types of investments: $2.2 billion in stock market value, $0.3 billion in private equity investments, $2.5 billion in global bonds, and $7.9 billion in Chinese short-term and long-term debt. Thus, the use of key financial statement metrics, including fraud models and ratios, has been shown here to provide enhanced corporate governance with risk management guidelines and applications. Boards of Directors need to pay attention to key financial statement metrics, which have been shown to work over and over again, as with Kaisa in this paper. These key metrics usually start with operating cash flows which then may indicate problems with debt service (the fixed charge coverage ratio which then may lead to bankruptcy predictions by the Altman bankruptcy model. To cover up such survival problems, companies often resort to earnings management and even fraudulent financial reporting which are typically red flagged by the quality of earnings, the quality of revenues, the new fraud model and the old fraud model

  1. Characterization of diatomite and its application for the retention of radiocobalt: role of environmental parameters.

    Science.gov (United States)

    Sheng, Guodong; Dong, Huaping; Li, Yimin

    2012-11-01

    Clay minerals have been extensively studied because of their strong sorption and complexation ability. In this work, diatomite was characterized by using acid-base titration. Retention of radionuclide (60)Co(II) from aqueous solution by sorption onto diatomite was investigated by using batch technique under various environmental conditions such as pH, ionic strength, humic acid (HA), fulvic acid (FA), and temperature. The results indicated that the sorption of Co(II) onto diatomite was strongly dependent on pH. At low pH value, the sorption of Co(II) was dominated by outer-sphere surface complexation and ion exchange with Na(+)/H(+) on diatomite surfaces, whereas inner-sphere surface complexation was the main sorption mechanism at high pH value. The D-R model fitted the sorption isotherms better than the Langmuir and Freundlich models. The thermodynamic parameters (ΔH(0), ΔS(0) and ΔG(0)) calculated from the temperature-dependent sorption isotherms suggested that the sorption of Co(II) was an endothermic and spontaneous process. In addition, diatomite showed higher sorption capacity than that of lots of the sorbents reported in the literatures we surveyed. From the results of Co(II) removal by diatomite, the optimum reaction conditions can be obtained for the maximum removal of Co(II) from water. It is clear that the best pH values of the system to remove Co(II) from solution by using diatomite are 7-8. Considering the low cost and effective disposal of Co(II)-contaminated wastewaters, the best condition for Co(II) removal is at room temperature and solid content of 0.5 g/L. The results might be important for assessing the potential of practical application of diatomite in Co(II) and related radionuclide pollution management. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. Searching for a Role of Nursing Personnel in Developing Landscape of Ehealth: Factors Determining Attitudes toward Key Patient Empowering Applications.

    Science.gov (United States)

    Duplaga, Mariusz

    2016-01-01

    Nurses may play an important role in the delivery of medical services based on the use of ehealth tools. Nevertheless, their taking an active role in an ehealth environment depends on their possessing the appropriate skills and mindset. The main objective of this paper was to assess nurses' opinions and to analyze the predictors of their acceptance of ehealth features relevant to patient empowerment with a strong focus on chronic care. A survey was conducted among nurses from hospital centers of south-eastern Poland based on a questionnaire designed to assess their attitudes toward the ehealth domain. The predictors of the nurses' acceptance of ehealth usage within specific contexts were assessed with uni- and multivariate logistic regression. An analysis was performed on data from 648 questionnaires retained after a quality check. The duration of Internet use was consistently related to higher acceptance of ehealth applications and more certainty regarding the reliability of health-related information available on the Internet. Nurses from urban medical centers were more skeptical about the use of specific ehealth solutions. Previous experience in using information technologies is the main factor influencing the acceptance of specific ehealth solutions relevant for care provided to patients suffering from chronic conditions.

  3. The Emerging Role of Proteomics in Precision Medicine: Applications in Neurodegenerative Diseases and Neurotrauma.

    Science.gov (United States)

    Alaaeddine, Rana; Fayad, Mira; Nehme, Eliana; Bahmad, Hisham F; Kobeissy, Firas

    2017-01-01

    neurodegenerative diseases and neurotrauma. However, other applications in proteomics such as "individual" proteome sequencing with its signature PTMs, have not been fully investigated as compared to the achievements in the genomics discipline This infers that proteomics research work has promising potential, yet to be discovered, in the precision medicine and comprises a major component of the personalized medicine infrastructure as it allows individual characterization of disease at the protein level. To conclude, the field of proteomics-based personalized medicine is still in its infancy compared to genomics field due to several technical and instrumentation-based obstacles; however, we anticipate to have this initiative leading in the coming future. This chapter will discuss briefly how neuroproteomics can impact personalized medicine in the fields of neurodegenerative disorders particularly in Alzheimer's disease and brain injury .

  4. Evaluation, testing and application of participatory approaches. The Role of Local Referenda. Deliverable D16a

    Energy Technology Data Exchange (ETDEWEB)

    Vojtechova, Hana (Nuclear Research Institute Rez plc (Czech Republic))

    2009-10-15

    , the only solution to a problem remains an open discussion on the basis of which all stakeholders reach a compromise. - Local referenda may be easily manipulated and certain interest groups may 'abuse' them - The outcome of a referendum is a picture of public opinion at a specific moment, but the moods and opinions of the public are likely to change, whereas the result of the referendum remains. - Representatives of local self-government or other organizations responsible for solution of the particular issue would be disturbed in their work; the citizens would unreasonably prolong the decision-making process. Naturally, it is not only important whether the citizens are politically active through the use of the institute of local referendum or other instrument of direct democracy, but also what impact these instruments have on politicians, local representatives and formation of policy at the local and state level as such. If public involvement is to work, it needs to be a two-way process. Not only do citizens need to let their voice be heard at various forms of consideration (deliberation) and discussions or through referenda and other citizens' initiatives, but also political representatives (people in power) have to take those views in some way into consideration in their decision-making. More consistent application of the principle of subsidiarity embedded in the primary law of the European Communities/European Union would facilitate the development of direct democracy, at least in European context. This principle stipulates that regulations should be adopted at the level closest to the citizens, i.e. at the lowest level of public administration where these are implemented. Unfortunately, the EC/EU itself faces considerable problems with application of this principle since the desire of non-elected European officials to influence the life of citizens in the EU is more than obvious. An illustrative example is the effort to harmonize tax legislation in

  5. Evaluation, testing and application of participatory approaches. The Role of Local Referenda. Deliverable D16a

    International Nuclear Information System (INIS)

    Vojtechova, Hana

    2009-10-01

    , the only solution to a problem remains an open discussion on the basis of which all stakeholders reach a compromise. - Local referenda may be easily manipulated and certain interest groups may 'abuse' them - The outcome of a referendum is a picture of public opinion at a specific moment, but the moods and opinions of the public are likely to change, whereas the result of the referendum remains. - Representatives of local self-government or other organizations responsible for solution of the particular issue would be disturbed in their work; the citizens would unreasonably prolong the decision-making process. Naturally, it is not only important whether the citizens are politically active through the use of the institute of local referendum or other instrument of direct democracy, but also what impact these instruments have on politicians, local representatives and formation of policy at the local and state level as such. If public involvement is to work, it needs to be a two-way process. Not only do citizens need to let their voice be heard at various forms of consideration (deliberation) and discussions or through referenda and other citizens' initiatives, but also political representatives (people in power) have to take those views in some way into consideration in their decision-making. More consistent application of the principle of subsidiarity embedded in the primary law of the European Communities/European Union would facilitate the development of direct democracy, at least in European context. This principle stipulates that regulations should be adopted at the level closest to the citizens, i.e. at the lowest level of public administration where these are implemented. Unfortunately, the EC/EU itself faces considerable problems with application of this principle since the desire of non-elected European officials to influence the life of citizens in the EU is more than obvious. An illustrative example is the effort to harmonize tax legislation in the EU countries

  6. Application of natural citric acid sources and their role on arsenic removal from drinking water: a green chemistry approach.

    Science.gov (United States)

    Majumder, Santanu; Nath, Bibhash; Sarkar, Simita; Islam, Sk Mijanul; Bundschuh, Jochen; Chatterjee, Debashis; Hidalgo, Manuela

    2013-11-15

    Solar Oxidation and Removal of Arsenic (SORAS) is a low-cost non-hazardous technique for the removal of arsenic (As) from groundwater. In this study, we tested the efficiency of natural citric acid sources extracted from tomato, lemon and lime to promote SORAS for As removal at the household level. The experiment was conducted in the laboratory using both synthetic solutions and natural groundwater samples collected from As-polluted areas in West Bengal. The role of As/Fe molar ratios and citrate doses on As removal efficiency were checked in synthetic samples. The results demonstrate that tomato juice (as citric acid) was more efficient to remove As from both synthetic (percentage of removal: 78-98%) and natural groundwater (90-97%) samples compared to lemon (61-83% and 79-85%, respectively) and lime (39-69% and 63-70%, respectively) juices. The As/Fe molar ratio and the citrate dose showed an 'optimized central tendency' on As removal. Anti-oxidants, e.g. 'hydroxycinnamates', found in tomato, were shown to have a higher capacity to catalyze SORAS photochemical reactions compared to 'flavanones' found in lemon or lime. The application of this method has several advantages, such as eco- and user- friendliness and affordability at the household level compared to other low-cost techniques. Copyright © 2012 Elsevier B.V. All rights reserved.

  7. The role of the clean development mechanism in facilitating the application of biomass renewable energy technologies in Malaysia

    International Nuclear Information System (INIS)

    Kheng, Wong Hwee; Hvid, Joergen

    2003-01-01

    The Malaysian Government's move to ratify the Kyoto Protocol in September 2001 reaffirms the country's support to combat global climate change. Although Malaysia is not bound by any commitments to reduce its greenhouse gas emissions, the opportunities that exist through the Clean Development Mechanism (CDM) could be two-fold: to contribute to the country's sustainable development objectives and to improve the energy supply security through the application of clean energy technologies such as renewable energy technologies. Malaysia is very dependent on fossil fuel based technologies for electricity generation and energy production. In 2001 almost 90% of the total energy input to power stations was derived from fossil fuels. Although the energy mix will continue to be predominantly based on fossil fuels, indigenous renewable energy resources may come to play a noticeable role in complementing the depleting fossil fuels. This paper focuses on how best to utilize the oil palm residues for electricity generation and energy production as these residues are the 'low hanging fruits' that are readily available. It compares the use of two different technological uses of residues: distributes power generation and co-firing with coal in large-scale power plants. The paper analyses the financial, economic and environmental impacts of these technologies, and it discusses the relative benefits of the technologies. In addition, the paper look into the barriers associated with each of the technologies, and it suggests possible policy interventions to be adopted in order to promote a viable and environmentally efficient use of the limited biomass resources. (au)

  8. Performance measurement in the UK construction industry and its role in supporting the application of lean construction concepts

    Directory of Open Access Journals (Sweden)

    Saad Sarhan

    2013-03-01

    Full Text Available Performance measurement has received substantial attention from researchers and the construction industry over the past two decades. This study sought to assess UK practitioners’ awareness of the importance of the use of appropriate performance measures and its role in supporting the application of Lean Construction (LC concepts. To enable the study to achieve its objectives, a review of a range of measurements developed to evaluate project performance including those devoted to support LC efforts was conducted. Consequently a questionnaire survey was developed and sent to 198 professionals in the UK construction industry as well as a small sample of academics with an interest in LC. Results indicated that although practitioners recognise the importance of the selection of non-financial performance measures, it has not been properly and widely implemented. The study identified the most common techniques used by UK construction organisations for performance measurement, and ranked a number of non-financial key performance indicators as significant. Some professed to have embraced the Last Planner System methodology as a means for performance measurement and organisational learning, while further questioning suggested otherwise. It was also suggested that substance thinking amongst professionals could be a significant hidden barrier that militates against the successful implementation of LC.

  9. The role of human error in risk analysis: Application to pre- and post-maintenance procedures of process facilities

    International Nuclear Information System (INIS)

    Noroozi, Alireza; Khakzad, Nima; Khan, Faisal; MacKinnon, Scott; Abbassi, Rouzbeh

    2013-01-01

    Human factors play an important role in the safe operation of a facility. Human factors include the systematic application of information about human characteristics and behavior to increase the safety of a process system. A significant proportion of human errors occur during the maintenance phase. However, the quantification of human error probabilities in the maintenance phase has not been given the amount of attention it deserves. This paper focuses on a human factors analysis in pre-and post- pump maintenance operations. The procedures for removing process equipment from service (pre-maintenance) and returning the equipment to service (post-maintenance) are considered for possible failure scenarios. For each scenario, human error probability is calculated for each activity using the Success Likelihood Index Method (SLIM). Consequences are also assessed in this methodology. The risk assessment is conducted for each component and the overall risk is estimated by adding individual risks. The present study is aimed at highlighting the importance of considering human error in quantitative risk analyses. The developed methodology has been applied to a case study of an offshore process facility

  10. Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing

    Directory of Open Access Journals (Sweden)

    Francis A. Ortega

    2018-01-01

    Full Text Available Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in pharmacological safety testing. Through the injection of computationally simulated conductances into isolated cardiomyocytes in a real-time continuous loop, dynamic clamp has greatly expanded the capabilities of patch clamp outside traditional static voltage and current protocols. Recent applications include fine manipulation of injected artificial conductances to identify promising drug targets in the prevention of arrhythmia and the direct testing of model-based hypotheses. Furthermore, dynamic clamp has been used to enhance existing experimental models by addressing their intrinsic limitations, which increased predictive power in identifying pro-arrhythmic pharmacological compounds. Here, we review the recent advances of the dynamic clamp technique in cardiac electrophysiology with a focus on its future role in the development of safety testing and discovery of anti-arrhythmic drugs.

  11. Brachytherapy, diagnostic radiology, mammographic radiology and ophthalmic applicators. An assessment of current and future needs in the UK and the role of NPL

    International Nuclear Information System (INIS)

    Angliss, R.; Bass, G.; Sander, T.

    2001-01-01

    Several UK hospitals were visited by NPL staff to discuss the current practises and future developments in brachytherapy, diagnostic and mammographic radiology and ophthalmic applicators. The results of the discussions are presented here, including NPL's role in each of these areas is discussed. (author)

  12. The role of oxytocin in relationships between dogs and humans and potential applications for the treatment of separation anxiety in dogs.

    Science.gov (United States)

    Thielke, Lauren E; Udell, Monique A R

    2017-02-01

    The hormone oxytocin plays an important role in attachment formation and bonding between humans and domestic dogs. Recent research has led to increased interest in potential applications for intranasal oxytocin to aid with the treatment of psychological disorders in humans. While a few studies have explored the effects of intranasally administered oxytocin on social cognition and social bonding in dogs, alternative applications have not yet been explored for the treatment of behavioural problems in this species. One potentially important application for intranasal oxytocin in dogs could be the treatment of separation anxiety, a common attachment disorder in dogs. Here we provide an overview of what is known about the role of oxytocin in the human-dog bond and canine separation anxiety, and discuss considerations for future research looking to integrate oxytocin into behavioural treatment based on recent findings from both the human and dog literature. © 2015 Cambridge Philosophical Society.

  13. Role of collective effects in dominance of scattering off thermal ions over Langmuir wave decay: Analysis, simulations, and space applications

    International Nuclear Information System (INIS)

    Cairns, Iver H.

    2000-01-01

    Langmuir waves driven to high levels by beam instabilities are subject to nonlinear processes, including the closely related processes of scattering off thermal ions (STI) and a decay process in which the ion response is organized into a product ion acoustic wave. Calculations of the nonlinear growth rates predict that the decay process should always dominate STI, creating two paradoxes. The first is that three independent computer simulation studies show STI proceeding, with no evidence for the decay at all. The second is that observations in space of type III solar radio bursts and Earth's foreshock, which the simulations were intended to model, show evidence for the decay proceeding but no evidence for STI. Resolutions to these paradoxes follow from the realization that a nonlinear process cannot proceed when its growth rate exceeds the minimum frequency of the participating waves, since the required collective response cannot be maintained and the waves cannot respond appropriately, and that a significant number of e-foldings and wave periods must be contained in the time available. It is shown that application of these ''collective'' and ''time scale'' constraints to the simulations explains why the decay does not proceed in them, as well as why STI proceeds in specific simulations. This appears to be the first demonstration that collective constraints are important in understanding nonlinear phenomena. Furthermore, applying these constraints to space observations, it is predicted that the decay should proceed (and dominate STI) in type III sources and the high beam speed regions of Earth's foreshock for a specific range of wave levels, with a possible role for STI alone at slightly higher wave levels. Deeper in the foreshock, for slower beams and weaker wave levels, the decay and STI are predicted to become ineffective. Suggestions are given for future testing of the collective constraint and an explanation for why waves in space are usually much weaker than

  14. Penetration level and impact of ITS applications: economic analysis of ITS deployment plans and the role of governments

    NARCIS (Netherlands)

    Bie, Jing; Vreeswijk, Jacob Dirk; van Berkum, Eric C.

    2012-01-01

    The impact of Intelligent Transportation System (ITS) applications, especially cooperative driver assistance systems, depends greatly on the percentage of users equipped (i.e. the penetration rate). The application may have little impact if only a few drivers are using the application. A higher

  15. APPLICATION METHODS TO INCREASE OF ROLE PLAYING ON LEARNING MATERIALS PRESERVING NKRI (PENERAPAN METODE ROLE PLAY UNTUK MENINGKATKAN HASIL BELAJAR PADA MATERI MENJAGA KEUTUHAN NKRI

    Directory of Open Access Journals (Sweden)

    Mahfudin -

    2016-10-01

    Full Text Available Abstract. Uncertainty in the nation's economy, the impact of globalization as well as various crises and disasters are problems that may lead to national disintegration which make few groups want to secede from NKRI. All these problems unilaterally are evidences of the unreliability of civic education learning as a subject that mandates to maintain the integrity of NKRI, not in the macro scope but in giving civic education as early as possible from the elementary school. The learning outcomes of civic education learning do not only include the acquisition of knowledge, but more to the acquisition of feeling and behavior. Consequently, in the pre-cycle, the researcher found difficulties to integrate the two domains, which made the learning outcomes below the mini-mum mastery criteria, students’ behavior lacking the feeling of love to their homeland and stu-dents’ motivation in learning low. To solve the problems, the researcher used role play method and as a result, after two cycles, students’ learning outcomes increased. The percentage of stu-dents’ minimum mastery criteria increased from 52% (score 75 to 69% in cycle I and 96% in cycle II. In addition, the students’ were more motivated in learning, followed ceremony in an or-derly manner, and behaved in ways that reflect the love of homeland. It can be concluded that ap-plying role play method in the lesson of preserving the integrity of NKRI at Grade V SDN Cilengkrang North Sumedang Regencey, students’ learning outcomes could be improved. Keywords: Role Play Method, Civic Education Learning, Integrity of The Unitary State of The Republic of Indonesia Abstrak. Ketidakpastian kondisi perekonomian bangsa, pengaruh globalisasi serta berbagai krisis dan bencana merupakan permasalahan yang merujuk ke arah disintegrasi bangsa. Sehingga segelintir kelompok ingin memisahkan diri dari NKRI. Semua permasalahan diatas secara sepihak merupakan suatu bukti ketidak mempanan pembelajaran PKn

  16. Advanced practice nursing role delineation in acute and critical care: application of the strong model of advanced practice.

    Science.gov (United States)

    Mick, D J; Ackerman, M H

    2000-01-01

    This purpose of this study was to differentiate between the roles of clinical nurse specialists and acute care nurse practitioners. Hypothesized blending of the clinical nurse specialist and acute care nurse practitioner roles is thought to result in an acute care clinician who integrates the clinical skills of the nurse practitioner with the systems knowledge, educational commitment, and leadership ability of the clinical nurse specialist. Ideally, this role blending would facilitate excellence in both direct and indirect patient care. The Strong Model of Advanced Practice, which incorporates practice domains of direct comprehensive care, support of systems, education, research, and publication and professional leadership, was tested to search for practical evidence of role blending. This descriptive, exploratory, pilot study included subjects (N = 18) solicited from an academic medical center and from an Internet advanced practice listserv. Questionnaires included self-ranking of expertise in practice domains, as well as valuing of role-related tasks. Content validity was judged by an expert panel of advanced practice nurses. Analyses of descriptive statistics revealed that clinical nurse specialists, who had more experience both as registered nurses and in the advanced practice nurse role, self-ranked their expertise higher in all practice domains. Acute care nurse practitioners placed higher importance on tasks related to direct comprehensive care, including conducting histories and physicals, diagnosing, and performing diagnostic procedures, whereas clinical nurse specialists assigned greater importance to tasks related to education, research, and leadership. Levels of self-assessed clinical expertise as well as valuing of role-related tasks differed among this sample of clinical nurse specialists and acute care nurse practitioners. Groundwork has been laid for continuing exploration into differentiation in advanced practice nursing roles. As the clinical

  17. Role of collective effects in dominance of scattering off thermal ions over Langmuir wave decay: Analysis, simulations, and space applications

    Energy Technology Data Exchange (ETDEWEB)

    Cairns, Iver H.

    2000-12-01

    Langmuir waves driven to high levels by beam instabilities are subject to nonlinear processes, including the closely related processes of scattering off thermal ions (STI) and a decay process in which the ion response is organized into a product ion acoustic wave. Calculations of the nonlinear growth rates predict that the decay process should always dominate STI, creating two paradoxes. The first is that three independent computer simulation studies show STI proceeding, with no evidence for the decay at all. The second is that observations in space of type III solar radio bursts and Earth's foreshock, which the simulations were intended to model, show evidence for the decay proceeding but no evidence for STI. Resolutions to these paradoxes follow from the realization that a nonlinear process cannot proceed when its growth rate exceeds the minimum frequency of the participating waves, since the required collective response cannot be maintained and the waves cannot respond appropriately, and that a significant number of e-foldings and wave periods must be contained in the time available. It is shown that application of these ''collective'' and ''time scale'' constraints to the simulations explains why the decay does not proceed in them, as well as why STI proceeds in specific simulations. This appears to be the first demonstration that collective constraints are important in understanding nonlinear phenomena. Furthermore, applying these constraints to space observations, it is predicted that the decay should proceed (and dominate STI) in type III sources and the high beam speed regions of Earth's foreshock for a specific range of wave levels, with a possible role for STI alone at slightly higher wave levels. Deeper in the foreshock, for slower beams and weaker wave levels, the decay and STI are predicted to become ineffective. Suggestions are given for future testing of the collective constraint and an explanation

  18. Applications of nutrient profiling: potential role in diet-related chronic disease prevention and the feasibility of a core nutrient-profiling system.

    Science.gov (United States)

    Sacks, G; Rayner, M; Stockley, L; Scarborough, P; Snowdon, W; Swinburn, B

    2011-03-01

    A number of different nutrient-profiling models have been proposed and several applications of nutrient profiling have been identified. This paper outlines the potential role of nutrient-profiling applications in the prevention of diet-related chronic disease (DRCD), and considers the feasibility of a core nutrient-profiling system, which could be modified for purpose, to underpin the multiple potential applications in a particular country. The 'Four 'P's of Marketing' (Product, Promotion, Place and Price) are used as a framework for identifying and for classifying potential applications of nutrient profiling. A logic pathway is then presented that can be used to gauge the potential impact of nutrient-profiling interventions on changes in behaviour, changes in diet and, ultimately, changes in DRCD outcomes. The feasibility of a core nutrient-profiling system is assessed by examining the implications of different model design decisions and their suitability to different purposes. There is substantial scope to use nutrient profiling as part of the policies for the prevention of DRCD. A core nutrient-profiling system underpinning the various applications is likely to reduce discrepancies and minimise the confusion for regulators, manufacturers and consumers. It seems feasible that common elements, such as a standard scoring method, a core set of nutrients and food components, and defined food categories, could be incorporated as part of a core system, with additional application-specific criteria applying. However, in developing and in implementing such a system, several country-specific contextual and technical factors would need to be balanced.

  19. Enhanced Deployment Strategy for Role-Based Hierarchical Application Agents in Wireless Sensor Networks with Established Clusterheads

    Science.gov (United States)

    Gendreau, Audrey

    2014-01-01

    Efficient self-organizing virtual clusterheads that supervise data collection based on their wireless connectivity, risk, and overhead costs, are an important element of Wireless Sensor Networks (WSNs). This function is especially critical during deployment when system resources are allocated to a subsequent application. In the presented research,…

  20. The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology

    International Nuclear Information System (INIS)

    Graves, David B

    2012-01-01

    Reactive oxygen species (ROS) and the closely related reactive nitrogen species (RNS) are often generated in applications of atmospheric pressure plasmas intended for biomedical purposes. These species are also central players in what is sometimes referred to as ‘redox’ or oxidation-reduction biology. Oxidation-reduction biochemistry is fundamental to all of aerobic biology. ROS and RNS are perhaps best known as disease-associated agents, implicated in diabetes, cancer, heart and lung disease, autoimmune disease and a host of other maladies including ageing and various infectious diseases. These species are also known to play active roles in the immune systems of both animals and plants and are key signalling molecules, among many other important roles. Indeed, the latest research has shown that ROS/RNS play a much more complex and nuanced role in health and ageing than previously thought. Some of the most potentially profound therapeutic roles played by ROS and RNS in various medical interventions have emerged only in the last several years. Recent research suggests that ROS/RNS are significant and perhaps even central actors in the actions of antimicrobial and anti-parasite drugs, cancer therapies, wound healing therapies and therapies involving the cardiovascular system. Understanding the ways ROS/RNS act in established therapies may help guide future efforts in exploiting novel plasma medical therapies. The importance of ROS and RNS to plant biology has been relatively little appreciated in the plasma biomedicine community, but these species are just as important in plants. It appears that there are opportunities for useful applications of plasmas in this area as well. (topical review)

  1. The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology

    Science.gov (United States)

    Graves, David B.

    2012-07-01

    Reactive oxygen species (ROS) and the closely related reactive nitrogen species (RNS) are often generated in applications of atmospheric pressure plasmas intended for biomedical purposes. These species are also central players in what is sometimes referred to as ‘redox’ or oxidation-reduction biology. Oxidation-reduction biochemistry is fundamental to all of aerobic biology. ROS and RNS are perhaps best known as disease-associated agents, implicated in diabetes, cancer, heart and lung disease, autoimmune disease and a host of other maladies including ageing and various infectious diseases. These species are also known to play active roles in the immune systems of both animals and plants and are key signalling molecules, among many other important roles. Indeed, the latest research has shown that ROS/RNS play a much more complex and nuanced role in health and ageing than previously thought. Some of the most potentially profound therapeutic roles played by ROS and RNS in various medical interventions have emerged only in the last several years. Recent research suggests that ROS/RNS are significant and perhaps even central actors in the actions of antimicrobial and anti-parasite drugs, cancer therapies, wound healing therapies and therapies involving the cardiovascular system. Understanding the ways ROS/RNS act in established therapies may help guide future efforts in exploiting novel plasma medical therapies. The importance of ROS and RNS to plant biology has been relatively little appreciated in the plasma biomedicine community, but these species are just as important in plants. It appears that there are opportunities for useful applications of plasmas in this area as well.

  2. [Application of role-play simulation in pre-clinical practice of the fourth grade students in department of endodontics].

    Science.gov (United States)

    Zhu, Lin-lin; Qiu, Li-hong; Qu, Liu; Xue, Ming; Yan, Lu

    2014-10-01

    To apply role- play simulation in pre-clinical practice of the fourth grade students in department of endodontics. Thirty-two students were randomly divided into 2 groups, there were 16 students in each group. Students in one group were taught with role-play simulation while the other group with lecture-based learning method. The teaching effect was measured with examination and questionnaire survey. The data was analyzed by using SPSS 17.0 software package. There were no significant differences in basic knowledge, case analysis and oral examination between 2 groups (P>0.05), but there was significant difference in history taking and medical records writing, practical examination and total scores between 2 groups (Pendodontics.

  3. Good alarm design plays a vital role in successful DCS implementation: Hard learned lessons from petrochemical applications

    International Nuclear Information System (INIS)

    Wilson, C.; Rothenberg, D.

    2006-01-01

    Nuclear operators are eager to update their automation infrastructure, but are apprehensive due to the consequences of failure. The process industries have learned that alarm design is critical to a successful Distributed Control System (DCS) implementation. This paper shares valuable insight into how alarms play a key role in successful management of upsets, help focus operator attention, and supply critical information during periods of high stress. (authors)

  4. Is there a role for TENS application in the control of diabetes mellitus in insulin-dependent patients?

    Science.gov (United States)

    Khan, Mueen Ullah

    2012-11-01

    An 80-year-old man with insulin-dependent diabetes mellitus presented to the hospital with low back pain. He was initially managed with non-steroidal anti-inflammatory drugs, tramadol and epidural steroid injection. Transcutaneous electrical nerve stimulation (TENS), applied on the back and buttocks, was subsequently advised. Initially, TENS was applied once every 24 hours. On improvement of pain symptoms, it was increased to thrice every 24 hours. The patient then complained of symptoms of hypoglycaemia (blood sugar level TENS resulted in raised blood sugar level. When TENS was restarted, the same hypoglycaemic response was noted. The insulin dosage was adjusted to half of the patient's routine daily requirement with continued application of TENS. This incidental finding has alerted us to hypoglycaemic episodes following TENS application, which may be due to effective pain control, decreased sympathetic stimulation, enhanced insulin sensitivity or altered muscle metabolism due to electrical stimulation.

  5. Application of heat stress in situ demonstrates a protective role of irradiation on photosynthetic performance in alpine plants

    OpenAIRE

    Buchner, Othmar; STOLL, Magdalena; Karadar, Matthias; Kranner, Ilse; Neuner, Gilbert

    2014-01-01

    The impact of sublethal heat on photosynthetic performance, photosynthetic pigments and free radical scavenging activity was examined in three high mountain species, R hododendron ferrugineum, S enecio incanus and R anunculus glacialis using controlled in situ applications of heat stress, both in darkness and under natural solar irradiation. Heat treatments applied in the dark reversibly reduced photosynthetic performance and the maximum quantum efficiency of photosystem II (Fv/Fm), which rem...

  6. Study of human mesenchymal stem cells plasticity into radiation injured tissues in a N.O.D./S.C.I.D. mouse model: therapeutic approach of the multiple organ dysfunction; Etude de la capacite plastique des Cellules Souches Mesenchymateuses humaines (CSM) apres irradiation du tissu receveur: approche therapeutique de l'atteinte multiorgane radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S

    2006-01-15

    The therapeutic potential of bone marrow-derived human mesenchymal stem cells (h.M.S.C.) has recently been brought into the spotlight of many fields of research. One possible application of the approach is the repair of injured tissues arising from side effects of radiation treatments and accidents. The first challenge in cell therapy is to assess the quality of the cell and the ability to retain their differentiation potential during the expansion process. Efficient delivery to the sites of intended action is also necessary. We addressed both questions using h.M.S.C. cultured and then infused to Non Obese Diabetes/Severe Combined Immunodeficiency (N.O.D./S.C.I.D.) mice submitted to total body irradiation. Further, we tested the impact of additional local irradiation superimposed to total body irradiation (T.B.I.), as a model of accidental irradiation. Our results showed that the h.M.S.C. used for transplant have been expanded without significant loss in their differentiation capacities. After transplantation into adult unconditioned mice, h.M.S.C. not only migrate in bone marrow but also into other tissues. Total body irradiation increased h.M.S.C. implantation in bone marrow and muscle and further led to engraftment in brain, heart, and liver. Local irradiation, in addition to T.B.I., increased both specific homing of injected cells to the injured tissues and to other tissues outside the local irradiation field. M.S.C. may participate to restoration of intestinal homeostasis 3 days post abdominal irradiation. This study suggests that using the potential of h.M.S.C. to home to various organs in response to tissue injuries could be a promising strategy to repair the radiation induced damages. (author)

  7. Study of human mesenchymal stem cells plasticity into radiation injured tissues in a N.O.D./S.C.I.D. mouse model: therapeutic approach of the multiple organ dysfunction; Etude de la capacite plastique des Cellules Souches Mesenchymateuses humaines (CSM) apres irradiation du tissu receveur: approche therapeutique de l'atteinte multiorgane radio-induite

    Energy Technology Data Exchange (ETDEWEB)

    Francois, S

    2006-01-15

    The therapeutic potential of bone marrow-derived human mesenchymal stem cells (h.M.S.C.) has recently been brought into the spotlight of many fields of research. One possible application of the approach is the repair of injured tissues arising from side effects of radiation treatments and accidents. The first challenge in cell therapy is to assess the quality of the cell and the ability to retain their differentiation potential during the expansion process. Efficient delivery to the sites of intended action is also necessary. We addressed both questions using h.M.S.C. cultured and then infused to Non Obese Diabetes/Severe Combined Immunodeficiency (N.O.D./S.C.I.D.) mice submitted to total body irradiation. Further, we tested the impact of additional local irradiation superimposed to total body irradiation (T.B.I.), as a model of accidental irradiation. Our results showed that the h.M.S.C. used for transplant have been expanded without significant loss in their differentiation capacities. After transplantation into adult unconditioned mice, h.M.S.C. not only migrate in bone marrow but also into other tissues. Total body irradiation increased h.M.S.C. implantation in bone marrow and muscle and further led to engraftment in brain, heart, and liver. Local irradiation, in addition to T.B.I., increased both specific homing of injected cells to the injured tissues and to other tissues outside the local irradiation field. M.S.C. may participate to restoration of intestinal homeostasis 3 days post abdominal irradiation. This study suggests that using the potential of h.M.S.C. to home to various organs in response to tissue injuries could be a promising strategy to repair the radiation induced damages. (author)

  8. The role and application of ion beam analysis for studies of plasma-facing components in controlled fusion devices

    Energy Technology Data Exchange (ETDEWEB)

    Rubel, Marek, E-mail: Marek.Rubel@ee.kth.se [EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Fusion Plasma Physics, Royal Institute of Technology (KTH), 100 44 Stockholm (Sweden); Petersson, Per [EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Fusion Plasma Physics, Royal Institute of Technology (KTH), 100 44 Stockholm (Sweden); Alves, Eduardo [EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisbon (Portugal); Brezinsek, Sebastijan [EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Institut für Klima- und Energieforschung, Forschungszentrum Jülich, D-52425 Jülich (Germany); Coad, Joseph Paul [EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CCFE, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Heinola, Kalle [EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); University of Helsinki, 00014 Helsinki (Finland); Mayer, Matej [EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Max-Planck-Institut für Plasmaphysik, 85478 Garching (Germany); Widdowson, Anna [EUROfusion Consortium, JET, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CCFE, Culham Science Centre, Abingdon OX14 3DB (United Kingdom)

    2016-03-15

    First wall materials in controlled fusion devices undergo serious modification by several physical and chemical processes arising from plasma–wall interactions. Detailed information is required for the assessment of material lifetime and accumulation of hydrogen isotopes in wall materials. The intention of this work is to give a concise overview of key issues in the characterization of plasma-facing materials and components in tokamaks, especially in JET with an ITER-Like Wall. IBA techniques play a particularly prominent role here because of their isotope selectivity in the low-Z range (1–10), high sensitivity and combination of several methods in a single run. The role of {sup 3}He-based NRA, RBS (standard and micro-size beam) and HIERDA in fuel retention and material migration studies is presented. The use of tracer techniques with rare isotopes (e.g. {sup 15}N) or marker layers on wall diagnostic components is described. Special instrumentation, development of equipment to enhance research capabilities and issues in handling of contaminated materials are addressed.

  9. The role and application of ion beam analysis for studies of plasma-facing components in controlled fusion devices

    Science.gov (United States)

    Rubel, Marek; Petersson, Per; Alves, Eduardo; Brezinsek, Sebastijan; Coad, Joseph Paul; Heinola, Kalle; Mayer, Matej; Widdowson, Anna

    2016-03-01

    First wall materials in controlled fusion devices undergo serious modification by several physical and chemical processes arising from plasma-wall interactions. Detailed information is required for the assessment of material lifetime and accumulation of hydrogen isotopes in wall materials. The intention of this work is to give a concise overview of key issues in the characterization of plasma-facing materials and components in tokamaks, especially in JET with an ITER-Like Wall. IBA techniques play a particularly prominent role here because of their isotope selectivity in the low-Z range (1-10), high sensitivity and combination of several methods in a single run. The role of 3He-based NRA, RBS (standard and micro-size beam) and HIERDA in fuel retention and material migration studies is presented. The use of tracer techniques with rare isotopes (e.g. 15N) or marker layers on wall diagnostic components is described. Special instrumentation, development of equipment to enhance research capabilities and issues in handling of contaminated materials are addressed.

  10. Improved workflow modelling using role activity diagram-based modelling with application to a radiology service case study.

    Science.gov (United States)

    Shukla, Nagesh; Keast, John E; Ceglarek, Darek

    2014-10-01

    The modelling of complex workflows is an important problem-solving technique within healthcare settings. However, currently most of the workflow models use a simplified flow chart of patient flow obtained using on-site observations, group-based debates and brainstorming sessions, together with historic patient data. This paper presents a systematic and semi-automatic methodology for knowledge acquisition with detailed process representation using sequential interviews of people in the key roles involved in the service delivery process. The proposed methodology allows the modelling of roles, interactions, actions, and decisions involved in the service delivery process. This approach is based on protocol generation and analysis techniques such as: (i) initial protocol generation based on qualitative interviews of radiology staff, (ii) extraction of key features of the service delivery process, (iii) discovering the relationships among the key features extracted, and, (iv) a graphical representation of the final structured model of the service delivery process. The methodology is demonstrated through a case study of a magnetic resonance (MR) scanning service-delivery process in the radiology department of a large hospital. A set of guidelines is also presented in this paper to visually analyze the resulting process model for identifying process vulnerabilities. A comparative analysis of different workflow models is also conducted. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  11. Application of aluminium in nuclear power plants; the role of corrosion under breakdown conditions within the hermetic zone

    International Nuclear Information System (INIS)

    Szontagh, Endre; Eva, Andras; Koevari, Tiborne

    1987-01-01

    Basic corrosion processes of aluminium determining the application possibilities as construction material within the containment of nuclear power plants were studied. The structure and stability of the oxide layers formed on aluminium surfaces depend on the pH, the temperature and the composition of the media and on the presence of alloying elements in the metal. It could be stated that hydrogen evolution due to the corrosion interaction of aluminium with the coolant of WWER-type reactors was less significant than calculated values. (V.N.)

  12. Radioimmunoassay of pancreatic glucagon. Improvement of method and application in order to determine the role of glucagon in the polytrauma

    International Nuclear Information System (INIS)

    Schrezenmeir, J.

    1980-01-01

    Radio-iodizing of glucagon under the application of chloralamine-T was examined and optimized with respect to its dependency on the concentration of the reacting agents, on the duration of reaction and on the pH value. The methods of other authors to purify labeled glucagon were put in contrast with the considerably faster and less complicated batch-procedure, in which Ouso G32 is applied. In order to improve the immunogenity of the weak antigen glucagon, different immunogenic preparations were produced and compared with each other. By the glucagon polymerisation with carbodiimid in guadinin HCl-solution, antibodies of excellent quality were obtained. With the glucagon polymers for the first time an immunogen was found, which produced exclusively so-called specific anti-glucagon sera. The influence of the albumine concentration and of the charcoal quantity on the separation of free and antibody-bound glucagon by means of dextran-covered charcoal was investigated. The early beginning of the investigations, the observation of the course, the temporal correlation of numerous other parameters and the fast application of shock-measures led to new knowledge about glucagon in the polytrauma. (orig./MG) [de

  13. The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical Applications

    Directory of Open Access Journals (Sweden)

    Eva Hemmer

    2012-01-01

    Full Text Available Upconversion and near-infrared emitting Gd2O3:Er3+,Yb3+ nanostructured phosphors (nanoparticles and nanorods for applications in bioimaging have been synthesized by precipitation methods and hydrothermal treatment. Variation of the material synthesis conditions (additives and pH allows controlling particle size (40 nm to μm range and rod aspect ratio (5 to 18. It was shown that PEG-b-PAAc (poly(ethylene glycol poly(acrylic acid block polymer is suitable to provide the required chemical durability, dispersion stability, and noncytotoxic behaviour for biomedical applications, where the coating of Gd2O3 with a protecting and biocompatible layer is essential in order to prevent the release of toxic Gd3+ ions. Physicochemical properties of the Gd2O3:Er3+,Yb3+ nanostructures modified with PEG-b-PAAc have been investigated by TG-DTA, FT-IR, and DLS revealing a strong influence of modification conditions, namely, pH of the reaction media, on the nature of the PEG-b-PAAc layer.

  14. Role of embodied energy in the European manufacturing industry: Application to short-term impacts of a carbon tax

    International Nuclear Information System (INIS)

    Bordigoni, Mathieu; Hita, Alain; Le Blanc, Gilles

    2012-01-01

    Role of energy in the manufacturing industry is a major concern for energy and environmental policy design. Issues like energy prices, security of supply and carbon mitigation are often connected to the industry and its competitiveness. This paper examines the role and consequences of embodied energy in the European industry. To this end, a multi-regional input–output analysis including 59 industrial sectors for all European Union countries and 17 more aggregated industries for other regions of the World is developed. Other segments of the economy are not included. This base is combined with energy consumption, carbon emission as well as bilateral trade data for every sector in all included countries. Our main result is that embodied energy in manufactured products' imports represents a significant aspect of the energy situation in European industries, with quantities close to the direct energy consumption. These flows can further be broken down for detailed analysis at the sector level thanks to the number of distinct industries included. Results demonstrate that an important part of embodied energy inside European products is not concerned with domestic energy price changes. In addition, a European-wide carbon tax would induce an unbalanced burden on industries and countries. - Highlights: ► We calculate embodied energy and carbon flows in the European and World industry. ► A multi-regional input–output analysis is used with a detailed nomenclature. ► National industries' energy prices dependence is a domestic issue. ► With a European carbon tax energy-intensive industries would be penalised. ► Such a tax may also induce competition distortion among EU countries.

  15. Physiologically Based Pharmacokinetic Modeling: Methodology, Applications, and Limitations with a Focus on Its Role in Pediatric Drug Development

    Directory of Open Access Journals (Sweden)

    Feras Khalil

    2011-01-01

    Full Text Available The concept of physiologically based pharmacokinetic (PBPK modeling was introduced years ago, but it has not been practiced significantly. However, interest in and implementation of this modeling technique have grown, as evidenced by the increased number of publications in this field. This paper demonstrates briefly the methodology, applications, and limitations of PBPK modeling with special attention given to discuss the use of PBPK models in pediatric drug development and some examples described in detail. Although PBPK models do have some limitations, the potential benefit from PBPK modeling technique is huge. PBPK models can be applied to investigate drug pharmacokinetics under different physiological and pathological conditions or in different age groups, to support decision-making during drug discovery, to provide, perhaps most important, data that can save time and resources, especially in early drug development phases and in pediatric clinical trials, and potentially to help clinical trials become more “confirmatory” rather than “exploratory”.

  16. Application of radiotracers in the assessment of prophylactic role of zinc in experimental model of colon carcinogenesis

    International Nuclear Information System (INIS)

    Dani, Vijayata; Vaiphei, K.; Dhawan, D.K.

    2010-01-01

    Full text: The present study elucidated the modulatory effects of zinc in 1,2 dimethylhydrazine (DMH) induced colon carcinogenesis using radiotracer techniques. Rats were segregated into four groups viz., untreated control, DMH treated, zinc treated, DMH+zinc treated. Colon carcinogenesis was induced through weekly subcutaneous injections of DMH (30 mg/Kg body weight) for 16 weeks. Zinc was supplemented to rats at a dose level of 227mg/L in drinking water, ad libitum. The prophylactic role of zinc was assessed by following radiotracer techniques viz: whole body biological half life of 65 Zn and 65 Zn biodistribution, subcellular distribution, uptake of 3 H-Thymidine to assess rate of DNA synthesis, radiorespirometric determination of 14 C-D-Glucose metabolism and in-vitro uptake of labeled aminoacids. The statistical significance of the data has been determined by using one way analysis of variance (ANOVA) followed by multiple post - hoc test. The carcinogenic state in the animals was confirmed by histopathological examination, whereby, well-differentiated signs of dysplasia were evident in colonic tissue sections of DMH treated rats. The biokinetics study of zinc revealed a significant decrease in the biological half life of 65 Zn. Also, DMH treatment caused a significant increase in the percent uptake values of 65 Zn in the colon, small intestine, kidney and blood, whereas a significant decrease was observed in the liver. The uptake rates of amino acids viz: 14 C-glycine, 14 C-alanine and 14 C-lysine were significantly higher in the DMH treated colons. Moreover, a significant increase in the uptake and turnover of 14 C-D-Glucose was also observed after DMH treatment. A significant increase in the ( 3 H)-thymidine uptake was observed following 16 weeks DMH treatment. However, supplementation of zinc significantly reversed the proliferative effect of DMH as evidenced by ameliorating the altered parameters. Radiotracer techniques play an important role in assessing

  17. A study of junction effect transistors and their roles in carbon nanotube field emission cathodes in compact pulsed power applications

    Science.gov (United States)

    Shui, Qiong

    This thesis is focusing on a study of junction effect transistors (JFETs) in compact pulsed power applications. Pulsed power usually requires switches with high hold-off voltage, high current, low forward voltage drop, and fast switching speed. 4H-SiC, with a bandgap of 3.26 eV (The bandgap of Si is 1.12eV) and other physical and electrical superior properties, has gained much attention in high power, high temperature and high frequency applications. One topic of this thesis is to evaluate if 4H-SiC JFETs have a potential to replace gas phase switches to make pulsed power system compact and portable. Some other pulsed power applications require cathodes of providing stable, uniform, high electron-beam current. So the other topic of this research is to evaluate if Si JFET-controlled carbon nanotube field emitter cold cathode will provide the necessary e-beam source. In the topic of "4H-SiC JFETs", it focuses on the design and simulation of a novel 4H-SiC normally-off VJFET with high breakdown voltage using the 2-D simulator ATLAS. To ensure realistic simulations, we utilized reasonable physical models and the established parameters as the input into these models. The influence of key design parameters were investigated which would extend pulsed power limitations. After optimizing the key design parameters, with a 50-mum drift region, the predicted breakdown voltage for the VJFET is above 8kV at a leakage current of 1x10-5A/cm2 . The specific on-state resistance is 35 mO·cm 2 at VGS = 2.7 V, and the switching speed is several ns. The simulation results suggest that the 4H-SiC VJFET is a potential candidate for improving switching performance in repetitive pulsed power applications. To evaluate the 4H-SiC VJFETs in pulsed power circuits, we extracted some circuit model parameters from the simulated I-V curves. Those parameters are necessary for circuit simulation program such as SPICE. This method could be used as a test bench without fabricating the devices to

  18. The role of herbometallic preparations in traditional medicine--a review on mica drug processing and pharmaceutical applications.

    Science.gov (United States)

    Wijenayake, Apsara; Pitawala, Amarasooriya; Bandara, Ratnayake; Abayasekara, Charmalie

    2014-09-11

    Biotite mica enriched with Fe(2+) ions are widely used as a major mineral ingredient in traditional pharmaceutical science of alchemy (Rasashastra). Abhrak bhasma (mica ash), a pharmaceutical product containing treated mica, is utilized, for example, in Ayurvedic treatments for ailments such as gastritis, renal disease, skin disease and mainly in rejuvenation formulations. However, the untreated mica minerals may be harmful when used directly, as they carry considerably high amounts of trace-elements that can cause undesirable effects in the human body. In order to remove toxic factors and produce readily absorbable materials having high nutrient capacity, specific thermal and chemical treatments (purification, detoxification, particle size reduction and incineration) are performed during the preparation of Rasashastra. This review evaluates the chemical and pharmacological aspects of mica ash as well as the technological aspects of mica ash production. The detailed literature review on the chemistry and scientific basis of mica ash, its preparation techniques, mica alterations and pharmaceutical applications was carried out by using published Ayurvedic text books and research articles, available from Science Direct, on mica minerals, mica ash and their physico-chemical alteration processes and pharmacological applications. During the purification and detoxification procedures, heating followed by quenching (in ionic medium) influences the structural distortion and the development of stress-induced cracks and spallations of the micaceous plates. Thus, the efficient diffusion of the external medium takes place at successive heating and quenching steps. Acidic organic liquids and animal byproducts can enhance the cation exchange capacity and solubility of mica. Further, these natural compounds facilitate the removal of toxic-elements in the structure. When treated-mica and paddy husks are tied up in a cloth and squeezed, particle size reduction and further

  19. The role of self–esteem and passion in determining resilience in athletes: an application of structural equation modelling

    Directory of Open Access Journals (Sweden)

    Nazmi BAYKÖSE

    2017-12-01

    Full Text Available Aim: The aim of this study was to investigate the role of self-esteem and passion in determining resilience in athletes. Material and Methods: 105 females (Xage=19.50±1.45 and 132 males (Xage=21.27±2.76 totally 237 (Xage=20.49±2.44 university athletes voluntarily participated in this study. “Personal Information Form”, “Sport Passion scale”, “Rosenberg Self-Esteem Scale” and “Brief Resilience Scale” were administered to athletes. Descriptive analysis and “Structural Equation Modelling (SEM” was used to test the relationships among resilience with self-esteem, obsessive and harmony passion level in athletes. According to the research results, concerned findings are listed below. Results: According to results of modelling which was conducted by structural equation modelling (SEM using AMOS, regression coefficient were 0.58 (p<0.001 for resilience and self-esteem, 0.56 (p<0.001 for resilience and harmony passion, -0.34 (p<0.001 for resilience and obsessive passion. Conclusion: In conclusion, there was a significant positive relationship among resilience, self-esteem and harmony passion. Furthermore, in conclusion, there was a significant negative relationship between resilience and obsessive passion.

  20. The role of nuclear energy for Korean long-term energy supply strategy : application of energy demand-supply model

    International Nuclear Information System (INIS)

    Chae, Kyu Nam

    1995-02-01

    An energy demand and supply analysis is carried out to establish the future nuclear energy system of Korea in the situation of environmental restriction and resource depletion. Based on the useful energy intensity concept, a long-term energy demand forecasting model FIN2USE is developed to integrate with a supply model. The energy supply optimization model MESSAGE is improved to evaluate the role of nuclear energy system in Korean long-term energy supply strategy. Long-term demand for useful energy used as an exogeneous input of the energy supply model is derived from the trend of useful energy intensity by sectors and energy carriers. Supply-side optimization is performed for the overall energy system linked with the reactor and nuclear fuel cycle strategy. The limitation of fossil fuel resources and the CO 2 emission constraints are reflected as determinants of the future energy system. As a result of optimization of energy system using linear programming with the objective of total discounted system cost, the optimal energy system is obtained with detailed results on the nuclear sector for various scenarios. It is shown that the relative importance of nuclear energy would increase especially in the cases of CO 2 emission constraint. It is concluded that nuclear reactor strategy and fuel cycle strategy should be incorporated with national energy strategy and be changed according to environmental restriction and energy demand scenarios. It is shown that this modelling approach is suitable for a decision support system of nuclear energy policy

  1. Personalized medicine and the role of health economics and outcomes research: issues, applications, emerging trends, and future research.

    Science.gov (United States)

    O'Donnell, John C

    2013-01-01

    The decade since the completion of the sequencing of the human genome has witnessed significant advances in the incorporation of genomic information in diagnostic, treatment, and reimbursement practices. Indeed, as case in point, there are now several dozen commercially available genomic tests routinely applied across a wide range of disease states in predictive or prognostic applications. Moreover, many involved in the advancement of personalized medicine would view emerging approaches to stratify patients in meaningful ways beyond genomic information as a signal of the progress made. Yet despite these advances, there remains a general sense of dissatisfaction about the progress of personalized medicine in terms of its contribution to the drug development process, to the efficiency and effectiveness of health care delivery, and ultimately to the provision of the right treatment to the right patient at the right time. Academicians, payers, and manufacturers alike are struggling not only with how to embed the new insights that personalized medicine promises but also with the fundamental issues of application in early drug development, implications for health technology assessment, new demands on traditional health economic and outcomes research methods, and implications for reimbursement and access. In fact, seemingly prosaic issues such as the definition and composition of the term "personalized medicine" are still unresolved. Regardless of these issues, practitioners are increasingly compelled to find practical solutions to the challenges and opportunities presented by the evolving face of personalized medicine today. Accordingly, the articles comprising this Special Issue offer applied perspectives geared toward professionals and policymakers in the field grappling with developing, assessing, implementing, and reimbursing personalized medicine approaches. Starting with a framework with which to characterize personalized medicine, this Special Issue proceeds to

  2. Role of computation fluid dynamics in aeronautical engineering (4). Development and applications of implicit TVD finete volume code

    Energy Technology Data Exchange (ETDEWEB)

    Shima, Eiji; Jounouchi, Tadamasa

    1986-12-01

    Potential analysis in aeronautic design has reached the stage of practical use although it involves problems concerning accuracy and restrictions on its application. On the other hand, numerical analysis using Euler and Navier-Stokes (N-S) equations is based on a highly accurate theory, so is preferable, but has not reached the stage of practical use because it involves problems that shapes that can be analyzed are restricted on account of factors relating to computation lattice generation and because it involves difficulty relating to computation time. The essential factor in numerical analysis is stoutness (numeric stability). From this viewpoint, an Euler/N-S method was developed; the theory begins with TVD finite volume code, and incorporates various types of improvement to raise accuracy and shorten computation time; hence, it satisfies design requirements. The use of this method helps get solution under a wide range of flow condition without any fine adjustments, such as artificial viscosity. (6 figs, 1 tab, 10 refs)

  3. Application of heat stress in situ demonstrates a protective role of irradiation on photosynthetic performance in alpine plants.

    Science.gov (United States)

    Buchner, Othmar; Stoll, Magdalena; Karadar, Matthias; Kranner, Ilse; Neuner, Gilbert

    2015-04-01

    The impact of sublethal heat on photosynthetic performance, photosynthetic pigments and free radical scavenging activity was examined in three high mountain species, Rhododendron ferrugineum, Senecio incanus and Ranunculus glacialis using controlled in situ applications of heat stress, both in darkness and under natural solar irradiation. Heat treatments applied in the dark reversibly reduced photosynthetic performance and the maximum quantum efficiency of photosystem II (Fv /Fm), which remained impeded for several days when plants were exposed to natural light conditions subsequently to the heat treatment. In contrast, plants exposed to heat stress under natural irradiation were able to tolerate and recover from heat stress more readily. The critical temperature threshold for chlorophyll fluorescence was higher under illumination (Tc (')) than in the dark (Tc). Heat stress caused a significant de-epoxidation of the xanthophyll cycle pigments both in the light and in the dark conditions. Total free radical scavenging activity was highest when heat stress was applied in the dark. This study demonstrates that, in the European Alps, heat waves can temporarily have a negative impact on photosynthesis and, importantly, that results obtained from experiments performed in darkness and/or on detached plant material may not reliably predict the impact of heat stress under field conditions. © 2014 The Authors. Plant, Cell & Environment published by John Wiley & Sons Ltd.

  4. The role of drug profiles as similarity metrics: applications to repurposing, adverse effects detection and drug-drug interactions.

    Science.gov (United States)

    Vilar, Santiago; Hripcsak, George

    2017-07-01

    Explosion of the availability of big data sources along with the development in computational methods provides a useful framework to study drugs' actions, such as interactions with pharmacological targets and off-targets. Databases related to protein interactions, adverse effects and genomic profiles are available to be used for the construction of computational models. In this article, we focus on the description of biological profiles for drugs that can be used as a system to compare similarity and create methods to predict and analyze drugs' actions. We highlight profiles constructed with different biological data, such as target-protein interactions, gene expression measurements, adverse effects and disease profiles. We focus on the discovery of new targets or pathways for drugs already in the pharmaceutical market, also called drug repurposing, in the interaction with off-targets responsible for adverse reactions and in drug-drug interaction analysis. The current and future applications, strengths and challenges facing all these methods are also discussed. Biological profiles or signatures are an important source of data generation to deeply analyze biological actions with important implications in drug-related studies. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  5. The role of post-earthquake structural safety in pre-earthquake retrof in decision: guidelines and applications

    International Nuclear Information System (INIS)

    Bazzurro, P.; Telleen, K.; Maffei, J.; Yin, J.; Cornell, C.A.

    2009-01-01

    Critical structures such as hospitals, police stations, local administrative office buildings, and critical lifeline facilities, are expected to be operational immediately after earthquakes. Any rational decision about whether these structures are strong enough to meet this goal or whether pre-empitive retrofitting is needed cannot be made without an explicit consideration of post-earthquake safety and functionality with respect to aftershocks. Advanced Seismic Assessment Guidelines offer improvement over previous methods for seismic evaluation of buildings where post-earthquake safety and usability is a concern. This new method allows engineers to evaluate the like hood that a structure may have restricted access or no access after an earthquake. The building performance is measured in terms of the post-earthquake occupancy classifications Green Tag, Yellow Tag, and Red Tag, defining these performance levels quantitatively, based on the structure's remaining capacity to withstand aftershocks. These color-coded placards that constitute an established practice in US could be replaced by the standard results of inspections (A to E) performed by the Italian Dept. of Civil Protection after an event. The article also shows some applications of these Guidelines to buildings of the largest utility company in California, Pacific Gas and Electric Company (PGE). [it

  6. The Role of Mobile Applications in Improving Alcohol Health Literacy in Young Adults With Type 1 Diabetes: Help or Hindrance?

    Science.gov (United States)

    Tamony, Peter; Holt, Richard; Barnard, Katharine

    2015-08-06

    Mobile health (mHealth) is an expanding field which includes the use of social media and mobile applications (apps). Apps are used in diabetes self-management but it is unclear whether these are being used to support safe drinking of alcohol by people with type 1 diabetes (T1DM). Alcohol health literacy is poor among young adults with T1DM despite specific associated risks. Systematic literature review followed by critical appraisal of commercially available apps. An eSurvey investigating access to mHealth technology, attitudes toward apps for diabetes management and their use to improve alcohol health literacy was completed by participants. Of 315 articles identified in the literature search, 7 met the inclusion criteria. Ten diabetes apps were available, most of which lacked the educational features recommended by clinical guidelines. In all, 27 women and 8 men with T1DM, aged 19-31 years were surveyed. Of them, 32 had access to a smartphone/tablet; 29 used apps; 20 used/had used diabetes apps; 3 had used apps related to alcohol and diabetes; 11 had discussed apps with their health care team; 22 felt more communication with their health care team would increase awareness of alcohol-associated risks. Use of mobile apps is commonplace but the use of apps to support safe drinking in this population was rare. Most participants expressed a preference for direct communication with their health care teams about this subject. Further research is needed to determine the preferences of health care professionals and how they can best support young adults in safe drinking. © 2015 Diabetes Technology Society.

  7. Accelerating the commercialization of university technologies for military healthcare applications: the role of the proof of concept process

    Science.gov (United States)

    Ochoa, Rosibel; DeLong, Hal; Kenyon, Jessica; Wilson, Eli

    2011-06-01

    The von Liebig Center for Entrepreneurism and Technology Advancement at UC San Diego (vonliebig.ucsd.edu) is focused on accelerating technology transfer and commercialization through programs and education on entrepreneurism. Technology Acceleration Projects (TAPs) that offer pre-venture grants and extensive mentoring on technology commercialization are a key component of its model which has been developed over the past ten years with the support of a grant from the von Liebig Foundation. In 2010, the von Liebig Entrepreneurism Center partnered with the U.S. Army Telemedicine and Advanced Technology Research Center (TATRC), to develop a regional model of Technology Acceleration Program initially focused on military research to be deployed across the nation to increase awareness of military medical needs and to accelerate the commercialization of novel technologies to treat the patient. Participants to these challenges are multi-disciplinary teams of graduate students and faculty in engineering, medicine and business representing universities and research institutes in a region, selected via a competitive process, who receive commercialization assistance and funding grants to support translation of their research discoveries into products or services. To validate this model, a pilot program focused on commercialization of wireless healthcare technologies targeting campuses in Southern California has been conducted with the additional support of Qualcomm, Inc. Three projects representing three different universities in Southern California were selected out of forty five applications from ten different universities and research institutes. Over the next twelve months, these teams will conduct proof of concept studies, technology development and preliminary market research to determine the commercial feasibility of their technologies. This first regional program will help build the needed tools and processes to adapt and replicate this model across other regions in the

  8. Therapeutic management of locally unresectable pancreatic cancer; Adenocarcinomes du pancreas localement evolues: modalites therapeutiques actuelles

    Energy Technology Data Exchange (ETDEWEB)

    Lombard-Bohas, C.; Saurin, J.C. [Centre Hospitalier Universitaire Edouard-Herriot, 69 - Lyon (France); Mornex, F. [Centre Hospitalier Universitaire Lyon-Sud, 69 - Pierre-Benite (France)

    1997-12-31

    Pancreatic cancer still have bad prognosis. At the time of diagnosis, less than 10 % of patients can undergo surgery with an overall 5-year survival rate of less than 2 %. For patients with localized pancreatic adenocarcinoma, the combination of radiation therapy and chemotherapy has been shown to control symptoms and to enhance patient survival. This treatment should be proposed to all the patients with good performance status and without icterus. Pain management should be optimized and often need morphinic and co-antalgic (anticonvulsants, steroids) consumption. The celiac plexus block with alcohol gives an excellent pain relief and should be more frequently used. (author)

  9. Microparticules magnetiques therapeutiques pour la chimio-embolisation ciblee du foie

    Science.gov (United States)

    Pouponneau, Pierre

    The proposed project introduces a therapeutic vector for the liver tumor treatment based on a new magnetic targeting strategy. The hypothesis of this thesis is that it is possible to design a therapeutic vector compatible with the constraints of liver chemoembolization and MRN in the hepatic artery to target the right/left lobe of the liver. This vector, referred to as therapeutic magnetic microcarriers (TMMC) is loaded with an antitumor drug and magnetic nanoparticles. A design study, based on a mathematical modeling of microparticle steering and a literature review on the chemoembolization, was done to optimize TMMC properties (diameter, Ms, nanoparticle choice and loading). Iron-cobalt (FeCo) nanoparticles were synthesized and annealed under inert conditions to improve their magnetic properties. These ferromagnetic nanoparticles possessed a mean diameter of 200 nm, measured by transmission electronic microscopy, and an Ms of 205 emu g-1, determined with a vibrating sample magnetometer. These nanoparticles, by their high Ms, allowed reducing by half the magnetic material loading in TMMC compared with the encapsulation of iron oxide nanoparticles. The nanoparticles coated with 10-nm graphite shell were protected from oxidation and thus they maintained their excellent magnetic properties. The design study was experimentally confirmed by the encapsulation of FeCo nanoparticles into poly(lactic-co-glycolic acid (PLGA) biodegradable microparticles. The latter were steered in vitro in a phantom mimicking the hepatic artery and its right/left bifurcation. The steering efficiency was determined by steering video analysis and the iron and cobalt ion concentrations were assayed by atomic absorption spectrometry in each bifurcation. FeCo nanoparticles were then co-encapsulated with doxorubicin (DOX) into PLGA microparticles. DOX is an antitumor drug widely used for HCC treatments. TMMC possessed a mean diameter of 52 mum, an Ms of 72 emu g-1 and they were loaded with 37% (w/w) of nanoparticles and 3% (w/w) of DOX. In vitro, after 3 days of elution in phosphate buffered saline solution, 54% of the DOX encapsulated remained in the TMMC. The elution was characterized by a fast release phase during one hour and then a slow kinetics. The steering was evaluated in vitro in a phantom mimicking the hepatic artery under physiological and interventional radiology conditions (injection by catheter, variation of distance between the catheter and the bifurcation from 30 to 20 mm, magnetic gradient from 200 to 400 mT m -1, flow velocity from 7.5 to 12 cm s-1). Steering efficiency was defined as the reduction of the TMMC (or drug) dose in the untargeted area in the presence of magnetic steering versus the negative control (no steering). The steering efficiency increased when the magnetic gradient increased. The efficiency decreased when the flow velocity increased and the catheter was closer to the bifurcation. The efficiency decreased with microparticles with lower steering properties (diameter of 30 mum and Ms of 49 emu g-1). This result confirmed that the TMMC properties were specific to the vascular network being targeted. In the optimal conditions, the steering efficiency reached 70%. The steering of TMMC was measured in vivo. An interventional radiology protocol compatible with MRN was developed to place the catheters, to reduce the hepatic artery blood velocity during the steering and to determine the MRI sequence parameters. TMMC induced signal loss on T2*-weighted magnetic resonance images because of their high Ms which allowed their easy localization in the tissues. The embolization of the hepatic artery branches by TMMC was confirmed by histological analysis. The sustained release of DOX was verified by measuring its plasmatic concentration. TMMC distribution in the tissues was determined by the histological analysis and DOX and cobalt concentration measurements. A significant difference in the TMMC distribution in the liver lobes between the group with MRN and the control group was obtained. The MRN allowed reducing the microparticle concentration in the untargeted area. In the optimal conditions, the steering efficiency reached 50%. The parameters influencing the steering efficiency in vitro were confirmed during in vivo tests. (Abstract shortened by UMI.)

  10. A net-zero building application and its role in exergy-aware local energy strategies for sustainability

    International Nuclear Information System (INIS)

    Kılkış, Şiir

    2012-01-01

    Highlights: ► Net-zero exergy targets are put forth for more energy-sufficient buildings and districts. ► A premier building that is the first LEED Platinum building in Turkey exemplifies this target. ► The building integrates low-exergy measures with PV/BIPV, CHP, GSHP, solar collectors and TES. ► Two districts in the south heating network of Stockholm are compared with this technology bundle. ► Net-zero exergy targets are related to a re-structuring of an exergy-aware energy value chain. - Abstract: Based on two case studies, this paper explores the nexus of exergy, net-zero targets, and sustainable cities as a means of analyzing the role of exergy-aware strategies at the building and district level. The first case study is a premier building in Ankara that is ready to meet the net-zero exergy target. It is also the first building in Turkey to receive the highest Platinum rating in Leadership in Energy and Environmental Design. A net-zero exergy building (NZEXB) is a building that has an annual sum of net-zero exergy transfer across the building-district boundary. This new target is made possible by lowered annual exergy consumption, (AEXC), and increased on-site production from a bundle of sustainable energy technologies. The modeled results of the building indicate that the reduced AEXC of 60 kW h/m 2 yr is met with on-site production of 62 kW h/m 2 yr. On-site production includes PV and building integrated PV, a micro-wind turbine, combined heat and power, GSHP, and solar collectors. Diversified thermal energy storage tanks further facilitate the exergy supply to meet with the exergy demand. The results of this case study provide key lessons to structure an energy value chain that is more aware of exergy, which are up-scalable to the district level when the bundle of sustainable energy technologies is zoomed out across a larger spatial area. These key lessons are then compared with the second case study of two districts in the south heating network

  11. Application of fundamental aquatic chemistry to the safety case and the role of thermodynamic reference data bases

    International Nuclear Information System (INIS)

    Altmaier, Marcus; Gaona, Xavier; Fellhauer, David; Geckeis, Horst

    2015-01-01

    All national and international programs developing a Nuclear Waste Disposal Safety Case have recognized the essential requirement of assessing aqueous (radionuclide) chemistry and establishing reliable thermodynamic databases. Long-term disposal of nuclear waste in deep underground repositories is the safest option to separate highly hazardous radionuclides from the environment. In order to predict the long-term performance of a repository for different evolution scenarios, the potentially relevant specific (geo)chemical systems are analyzed. This requires a detailed understanding of solubility, speciation and thermodynamics for all relevant components including radionuclides, and the availability of reliable thermodynamic data and databases as fundamental input for integral geochemical model calculations and hence PA. Radionuclide solubility and speciation strongly depend on chemical conditions (pH, E h , matrix electrolyte system and ionic strength) with additional factors like the presence of complexing ligands or temperature further impacting solution chemistry. As the fundamental chemical key processes are known and convincingly described by general laws of nature (→ solution thermodynamics), the long-term behavior of a repository system can be analyzed over geological timescales using geochemical tools. A key application of fundamental aquatic chemistry in the Safety Case is the determination of solubility limits (radionuclide source terms). Based upon fundamental chemical information (on solid phases, complexation reactions, activity coefficients, etc.), the maximum amount of radionuclides potentially dissolved in a given volume of solution and transported away from the repository, are quantified. A detailed understanding of radionuclide chemistry is also crucial for neighboring fields. For example, advanced mechanistic understanding and modeling of sorption processes at the solid liquid interphase, waste dissolution processes, secondary phase and solid

  12. Application of fundamental aquatic chemistry to the safety case and the role of thermodynamic reference data bases

    Energy Technology Data Exchange (ETDEWEB)

    Altmaier, Marcus; Gaona, Xavier; Fellhauer, David; Geckeis, Horst [Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen (Germany). Inst. for Nuclear Waste Disposal

    2015-07-01

    All national and international programs developing a Nuclear Waste Disposal Safety Case have recognized the essential requirement of assessing aqueous (radionuclide) chemistry and establishing reliable thermodynamic databases. Long-term disposal of nuclear waste in deep underground repositories is the safest option to separate highly hazardous radionuclides from the environment. In order to predict the long-term performance of a repository for different evolution scenarios, the potentially relevant specific (geo)chemical systems are analyzed. This requires a detailed understanding of solubility, speciation and thermodynamics for all relevant components including radionuclides, and the availability of reliable thermodynamic data and databases as fundamental input for integral geochemical model calculations and hence PA. Radionuclide solubility and speciation strongly depend on chemical conditions (pH, E{sub h}, matrix electrolyte system and ionic strength) with additional factors like the presence of complexing ligands or temperature further impacting solution chemistry. As the fundamental chemical key processes are known and convincingly described by general laws of nature (→ solution thermodynamics), the long-term behavior of a repository system can be analyzed over geological timescales using geochemical tools. A key application of fundamental aquatic chemistry in the Safety Case is the determination of solubility limits (radionuclide source terms). Based upon fundamental chemical information (on solid phases, complexation reactions, activity coefficients, etc.), the maximum amount of radionuclides potentially dissolved in a given volume of solution and transported away from the repository, are quantified. A detailed understanding of radionuclide chemistry is also crucial for neighboring fields. For example, advanced mechanistic understanding and modeling of sorption processes at the solid liquid interphase, waste dissolution processes, secondary phase and

  13. The early warning application role in facing the environmental crisis and disasters: "Preliminarily risk management strategy for the greater city of Cairo"

    Directory of Open Access Journals (Sweden)

    Ghoneem Yousef M.

    2013-01-01

    Full Text Available Natural disasters are inevitable and it is almost impossible to fully recoup the damage caused by the disasters. But it is possible to minimize the potential risk by developing disaster early warning strategies, methods using the new technology applications which play a crucial role in efficient mitigation and management of disasters. This paper describes the importance of the remote sensing and Geographical Information System (GIS in evolving a suitable strategy for disaster, crises and risk management using these technologies. The main objective of this paper is to make a Preliminary risk management plan (it is a logical and systematic method of identifying, analyzing, treating and monitoring the risks involved in any activity or process. This process helps Administrations to focus on priorities and in decisions on deploying limited resources to deal with the highest risks using the Environmental risk map of the greater city of Cairo demonstrating the most high-risk administrative areas in the city, supported by field evidence and different sources of information. to reduce the loss of life and property and protect the Nation from all hazards, including natural disasters and other man-made disasters, by leading and supporting the Nation in a risk-based, comprehensive emergency management system of preparedness, protection, response, recovery, and mitigation. This study has shown that how can the early warning Applications can be useful in analyzing, Integrating and managing different datasets for predicting the environmental crises and disasters that may affect the urbanism inside the city and help in the preparation of the Risk management plan.

  14. Role of mHealth applications for improving antenatal and postnatal care in low and middle income countries: a systematic review.

    Science.gov (United States)

    Feroz, Anam; Perveen, Shagufta; Aftab, Wafa

    2017-11-07

    From 1990 to 2015, the number of maternal deaths globally has dropped by 43%. Despite this, progress in attaining MDG 5 is not remarkable in LMICs. Only 52% of pregnant women in LMICs obtain WHO recommended minimum of four antenatal consultations and the coverage of postnatal care is relatively poor. In recent years, the increased cellphone penetration has brought the potential for mHealth to improve preventive maternal healthcare services. The objective of this review is to assess the effectiveness of mHealth solutions on a range of maternal health outcomes by categorizing the interventions according to the types of mHealth applications. Three international online electronic databases were searched between January 1, 2000 and January 25, 2016 to identify studies exploring the role of mHealth solutions in improving preventive maternal healthcare services. Of 1262 titles screened after duplication, 69 potentially relevant abstracts were obtained. Out of 69 abstracts, 42 abstracts were shortlisted. Full text of 42 articles was reviewed using data extraction sheet. A total of 14 full text studies were included in the final analysis. The 14 final studies were categorized in to five mHealth applications defined in the conceptual framework. Based on our analysis, the most reported use of mHealth was for client education and behavior change communication, such as SMS and voice reminders [n = 9, 65%]. The categorization provided the understanding that much work have been done on client education and behavior change communication. Most of the studies showed that mHealth interventions have proven to be effective to improve antenatal care and postnatal care services, especially those that are aimed at changing behavior of pregnant women and women in postnatal period. However, little evidence exists on other type of mHealth applications. This review suggests that mHealth solutions targeted at pregnant women and women in postnatal period can improve preventive maternal

  15. Role of mHealth applications for improving antenatal and postnatal care in low and middle income countries: a systematic review

    Directory of Open Access Journals (Sweden)

    Anam Feroz

    2017-11-01

    Full Text Available Abstract Background From 1990 to 2015, the number of maternal deaths globally has dropped by 43%. Despite this, progress in attaining MDG 5 is not remarkable in LMICs. Only 52% of pregnant women in LMICs obtain WHO recommended minimum of four antenatal consultations and the coverage of postnatal care is relatively poor. In recent years, the increased cellphone penetration has brought the potential for mHealth to improve preventive maternal healthcare services. The objective of this review is to assess the effectiveness of mHealth solutions on a range of maternal health outcomes by categorizing the interventions according to the types of mHealth applications. Methods Three international online electronic databases were searched between January 1, 2000 and January 25, 2016 to identify studies exploring the role of mHealth solutions in improving preventive maternal healthcare services. Of 1262 titles screened after duplication, 69 potentially relevant abstracts were obtained. Out of 69 abstracts, 42 abstracts were shortlisted. Full text of 42 articles was reviewed using data extraction sheet. A total of 14 full text studies were included in the final analysis. Results The 14 final studies were categorized in to five mHealth applications defined in the conceptual framework. Based on our analysis, the most reported use of mHealth was for client education and behavior change communication, such as SMS and voice reminders [n = 9, 65%]. The categorization provided the understanding that much work have been done on client education and behavior change communication. Most of the studies showed that mHealth interventions have proven to be effective to improve antenatal care and postnatal care services, especially those that are aimed at changing behavior of pregnant women and women in postnatal period. However, little evidence exists on other type of mHealth applications. Conclusion This review suggests that mHealth solutions targeted at pregnant women

  16. Jet formation and shock wave emission during collapse of ultrasound-induced cavitation bubbles and their role in the therapeutic applications of high-intensity focused ultrasound.

    Science.gov (United States)

    Brujan, E A; Ikeda, T; Matsumoto, Y

    2005-10-21

    The dynamics of inertial cavitation bubbles produced by short pulses of high-intensity focused ultrasound near a rigid boundary are studied to get a better understanding of the role of jet formation and shock wave emission during bubble collapse in the therapeutic applications of ultrasound. The bubble dynamics are investigated by high-speed photography with up to 2 million frames/s and acoustic measurements, as well as by numerical calculations. The significant parameter of this study is the dimensionless stand-off, gamma, which is defined as the distance of the bubble centre at its maximum expansion scaled by the maximum bubble radius. High-speed photography is applied to observe the bubble motion and the velocity of the liquid jet formed during bubble collapse. Hydrophone measurements are used to determine the pressure and the duration of the shock wave emitted during bubble rebound. Calculations yield the variation with time of the bubble wall, the maximum velocity and the kinetic energy of the re-entrant jet. The comparisons between experimental and numerical data are favourable with regard to both shape history and translational motion of the bubble. The acoustic energy constitutes the largest individual amount in the energy balance of bubble collapse. The ratio of the shock wave energy, measured at 10 mm from the emission centre, to the cavitation bubble energy was 1:2.4 at gamma = 1.55 and 1:3.5 at gamma = 1. At this distance, the shock wave pressure ranges from 0.122 MPa, at gamma = 1, to 0.162 MPa, at gamma = 1.55, and the temporal duration at the half maximum level is 87 ns. The maximum jet velocity ranges from 27 m s(-1), at gamma = 1, to 36 m s(-1), at gamma = 1.55. For gamma < 1.2, the re-entrant jet can generate an impact pressure on the nearby boundary larger than 50 MPa. We discuss the implications of the results for the therapeutic applications of high-intensity focused ultrasound.

  17. Jet formation and shock wave emission during collapse of ultrasound-induced cavitation bubbles and their role in the therapeutic applications of high-intensity focused ultrasound

    International Nuclear Information System (INIS)

    Brujan, E A; Ikeda, T; Matsumoto, Y

    2005-01-01

    The dynamics of inertial cavitation bubbles produced by short pulses of high-intensity focused ultrasound near a rigid boundary are studied to get a better understanding of the role of jet formation and shock wave emission during bubble collapse in the therapeutic applications of ultrasound. The bubble dynamics are investigated by high-speed photography with up to 2 million frames/s and acoustic measurements, as well as by numerical calculations. The significant parameter of this study is the dimensionless stand-off, γ, which is defined as the distance of the bubble centre at its maximum expansion scaled by the maximum bubble radius. High-speed photography is applied to observe the bubble motion and the velocity of the liquid jet formed during bubble collapse. Hydrophone measurements are used to determine the pressure and the duration of the shock wave emitted during bubble rebound. Calculations yield the variation with time of the bubble wall, the maximum velocity and the kinetic energy of the re-entrant jet. The comparisons between experimental and numerical data are favourable with regard to both shape history and translational motion of the bubble. The acoustic energy constitutes the largest individual amount in the energy balance of bubble collapse. The ratio of the shock wave energy, measured at 10 mm from the emission centre, to the cavitation bubble energy was 1:2.4 at γ = 1.55 and 1:3.5 at γ = 1. At this distance, the shock wave pressure ranges from 0.122 MPa, at γ = 1, to 0.162 MPa, at γ 1.55, and the temporal duration at the half maximum level is 87 ns. The maximum jet velocity ranges from 27 m s -1 , at γ = 1, to 36 m s -1 , at γ = 1.55. For γ < 1.2, the re-entrant jet can generate an impact pressure on the nearby boundary larger than 50 MPa. We discuss the implications of the results for the therapeutic applications of high-intensity focused ultrasound

  18. Water-Deficit Tolerance in Sweet Potato [Ipomoea batatas (L. Lam.] by Foliar Application of Paclobutrazol: Role of Soluble Sugar and Free Proline

    Directory of Open Access Journals (Sweden)

    Suravoot Yooyongwech

    2017-08-01

    Full Text Available The objective of this study was to elevate water deficit tolerance by improving soluble sugar and free proline accumulation, photosynthetic pigment stabilization, photosynthetic abilities, growth performance and storage root yield in sweet potato cv. ‘Tainung 57’ using a foliar application of paclobutrazol (PBZ. The experiment followed a Completely Randomized Block Design with four concentrations of PBZ: 0 (control, 17, 34, and 51 μM before exposure to 47.5% (well irrigation, 32.3% (mild water deficit or 17.5% (severe water deficit soil water content. A sweet potato cultivar, ‘Japanese Yellow’, with water deficit tolerance attributes was the positive check in this study. Total soluble sugar content (sucrose, glucose, and fructose increased by 3.96-folds in ‘Tainung 57’ plants treated with 34 μM PBZ grown under 32.3% soil water content (SWC compared to the untreated plants, adjusting osmotic potential in the leaves and controlling stomatal closure (represented by stomatal conductance and transpiration rate. In addition, under the same treatment, free proline content (2.15 μmol g-1 FW increased by 3.84-folds when exposed to 17.5% SWC. PBZ had an improved effect on leaf size, vine length, photosynthetic pigment stability, chlorophyll fluorescence, and net photosynthetic rate; hence, delaying wilting symptoms and maintaining storage root yield (26.93 g plant-1 at the harvesting stage. A positive relationship between photon yield of PSII (ΦPSII and net photosynthetic rate was demonstrated (r2 = 0.73. The study concludes that soluble sugar and free proline enrichment in PBZ-pretreated plants may play a critical role as major osmoprotectant to control leaf osmotic potential and stomatal closure when plants were subjected to low soil water content, therefore, maintaining the physiological and morphological characters as well as storage root yield.

  19. Water-Deficit Tolerance in Sweet Potato [Ipomoea batatas (L.) Lam.] by Foliar Application of Paclobutrazol: Role of Soluble Sugar and Free Proline.

    Science.gov (United States)

    Yooyongwech, Suravoot; Samphumphuang, Thapanee; Tisarum, Rujira; Theerawitaya, Cattarin; Cha-Um, Suriyan

    2017-01-01

    The objective of this study was to elevate water deficit tolerance by improving soluble sugar and free proline accumulation, photosynthetic pigment stabilization, photosynthetic abilities, growth performance and storage root yield in sweet potato cv. 'Tainung 57' using a foliar application of paclobutrazol (PBZ). The experiment followed a Completely Randomized Block Design with four concentrations of PBZ: 0 (control), 17, 34, and 51 μM before exposure to 47.5% (well irrigation), 32.3% (mild water deficit) or 17.5% (severe water deficit) soil water content. A sweet potato cultivar, 'Japanese Yellow', with water deficit tolerance attributes was the positive check in this study. Total soluble sugar content (sucrose, glucose, and fructose) increased by 3.96-folds in 'Tainung 57' plants treated with 34 μM PBZ grown under 32.3% soil water content (SWC) compared to the untreated plants, adjusting osmotic potential in the leaves and controlling stomatal closure (represented by stomatal conductance and transpiration rate). In addition, under the same treatment, free proline content (2.15 μmol g -1 FW) increased by 3.84-folds when exposed to 17.5% SWC. PBZ had an improved effect on leaf size, vine length, photosynthetic pigment stability, chlorophyll fluorescence, and net photosynthetic rate; hence, delaying wilting symptoms and maintaining storage root yield (26.93 g plant -1 ) at the harvesting stage. A positive relationship between photon yield of PSII (Φ PSII ) and net photosynthetic rate was demonstrated ( r 2 = 0.73). The study concludes that soluble sugar and free proline enrichment in PBZ-pretreated plants may play a critical role as major osmoprotectant to control leaf osmotic potential and stomatal closure when plants were subjected to low soil water content, therefore, maintaining the physiological and morphological characters as well as storage root yield.

  20. Enhanced reality live role playing

    OpenAIRE

    Söderberg, Jonas; Waern, Annika; Åkesson, Karl-Petter; Björk, Staffan; Falk, Jennica

    2004-01-01

    Live role-playing is a form of improvisational theatre played for the experience of the performers and without an audience. These games form a challenging application domain for ubiquitous technology. We discuss the design options for enhanced reality live role-playing and the role of technology in live role-playing games.

  1. Factors affecting initial disability allowance rates for the Disability Insurance and Supplemental Security Income programs: the role of the demographic and diagnostic composition of applicants and local labor market conditions.

    Science.gov (United States)

    Rupp, Kalman

    2012-01-01

    Various factors outside the control of decision makers may affect the rate at which disability applications are allowed or denied during the initial step of eligibility determination in the Social Security Disability Insurance (DI) and Supplemental Security Income (SSI) programs. In this article, using individual-level data on applications, I estimate the role of three important factors--the demographic characteristics of applicants, the diagnostic mix of applicants, and the local unemployment rate--in affecting the probability of an initial allowance and state allowance rates. I use a random sample of initial determinations from 1993 through 2008 and a fixed-effects multiple regression framework. The empirical results show that the demographic and diagnostic characteristics of applicants and the local unemployment rate substantially affect the initial allowance rate. An increase in the local unemployment rate tends to be associated with a decrease in the initial allowance rate. This negative relationship holds for adult DI and SSI applicants and for SSI childhood applicants.

  2. Marital Processes Linking Gender Role Attitudes and Marital Satisfaction Among Mexican-Origin Couples: Application of an Actor-Partner Interdependence Mediation Model.

    Science.gov (United States)

    Helms, Heather M; Supple, Andrew J; Hengstebeck, Natalie D; Wood, Claire A; Rodriguez, Yuliana

    2018-01-24

    Informed by dyadic approaches and culturally informed, ecological perspectives of marriage, we applied an actor-partner interdependence mediation model (APIMeM) in a sample of 120 Mexican-origin couples to examine (a) the associations linking Mexican immigrant husbands' and wives' gender role attitudes to marital satisfaction directly and indirectly through marital processes (i.e., warmth and negativity) and (b) whether the associations between spouses' gender role attitudes and marital processes were moderated by wives' employment. Although previous research has identified spouses' gender role attitudes as potential predictors of spouses' marital satisfaction, no study has examined these links in a dyadic model that elucidates how gender role attitudes may operate through processes to shape marital satisfaction and conditions under which associations may differ. We found that when spouses reported less sex-typed attitudes, their partners reported feeling more connected to them and more satisfied with the marriage, regardless of whether wives were employed. Our results suggest that marital satisfaction was highest for those Mexican-origin couples in which marital partners were less sex-typed in their attitudes about marital roles to the extent that partners' attitudinal role flexibility promoted spouses' feelings of warmth and connection to their partner. © 2018 Family Process Institute.

  3. An application of multiplier analysis in analyzing the role of information and communication technology sectors on Indonesian national economy: 1990-2005

    International Nuclear Information System (INIS)

    Zuhdi, Ubaidillah

    2015-01-01

    The purpose of this study is to continue the previous studies which focused on Indonesian Information and Communication Technology (ICT) sectors. More specifically, this study aims to analyze the role of ICT sectors on Indonesian national economy using simple household income multiplier, one of the analysis tools in Input-Output (IO) analysis. The analysis period of this study is from 1990-2005. The results show that the sectors did not have an important role on the national economy of Indonesia on the period. Besides, the results also show that, from the point of view of the multiplier, Indonesian national economy tended to stable during the period

  4. An analysis of the role of information and communication technology sectors on Japanese national economy from 1995 through 2005: An application of multiplier analysis

    International Nuclear Information System (INIS)

    Zuhdi, Ubaidillah

    2015-01-01

    The purpose of this study is to continue the previous studies which focused on Japanese Information and Communication Technology (ICT) sectors. More specifically, this study aims to analyze the role of ICT sectors on Japanese national economy using simple household income multiplier, one of the analysis instruments in Input-Output (IO) analysis. The analysis period of this study is from 1995-2005. The results show that the sectors did not have an important role on the national economy of Japan on the period. Besides, the results also show that, from the point of view of the multiplier, Japanese national economy tended to stable during the period

  5. The role of central, regional and local administrations in the application of the Kyoto protocol in the forestry sector in Italy

    Directory of Open Access Journals (Sweden)

    Pompei E

    2007-01-01

    Full Text Available According to art. 3.3 and 3.4 of the Kyoto Protocol and subsequent UNFCCC COP's and national decisions, Italy shall report the net changes in GHG emissions by sources and removals by sinks resulting from afforestation, reforestation and deforestation (art. 3.3 and forest management (art. 3.4 activities. To assess art. 3.3 activities, Italy will define methods to estimate land use changes occurring after 31 December 1989. The paper considers the key-role that central administration shall have, as well as the role of regional and local administrations in order to solve some specific topics regarding data collection and management issues.

  6. Developing the Librarians' Role in Supporting Grant Applications and Reducing Waste in Research: Outcomes from a Literature Review and Survey in the NIHR Research Design Service

    Science.gov (United States)

    Edmunds Otter, Mary L.; Wright, Judy M.; King, Natalie V.

    2017-01-01

    Librarians and information specialists' involvement during the development of grant applications for external funding can save researchers' time, provide specialist support, and contribute to reducing avoidable waste in research. This article presents a survey of information specialists working for the National Institute for Health Research's…

  7. Students as First-Time Voters: The Role of Voter Advice Applications in Self-Reflection on Party Choice and Political Identity

    Science.gov (United States)

    Kristensen, Niels Nørgaard; Solhaug, Trond

    2017-01-01

    Purpose: This article analyses what characterises first time voters' self-reflections on party choice as they use voter advice applications. Method: This study is based on interviews of 28 Norwegian students (age 18-20) preparing themselves for their first election. Findings: Finding a party to vote for is primarily characterized by a process of…

  8. The role of prevention-oriented attitudes towards nature in people's judgment of new applications of genomics techniques in soil ecology

    NARCIS (Netherlands)

    de Boer, J.

    2010-01-01

    New applications of genomics techniques in soil ecology may provide people with fresh insights into the richness of microbial life forms and natural methods to build on the "self-cleaning capacity" of soils. Because genetic modification might also be involved, this paper examines people's judgments

  9. Emerging role of human factors and ergonomics in healthcare delivery – A new field of application and influence for the IEA

    Science.gov (United States)

    Carayon, Pascale

    2014-01-01

    Recent developments of research and application of Human Factors and Ergonomics (HFE) are described, in particular the domain of healthcare delivery. HFE activities in this domain are highlighted and challenges for the discipline and the International Ergonomics Association are presented. PMID:22317500

  10. Infusion Reactions Associated with the Medical Application of Monoclonal Antibodies: The Role of Complement Activation and Possibility of Inhibition by Factor H

    OpenAIRE

    Tamás Fülöp; Tamás Mészáros; Gergely Tibor Kozma; János Szebeni; Mihály Józsi

    2018-01-01

    Human application of monoclonal antibodies (mAbs), enzymes, as well as contrast media and many other particulate drugs and agents referred to as “nanomedicines”, can initiate pseudoallergic hypersensitivity reactions, also known as infusion reactions. These may in part be mediated by the activation of the complement system, a major humoral defense system of innate immunity. In this review, we provide a brief outline of complement activation-related pseudoallergy (CARPA) in general, and then f...

  11. The role of IGFs and leptin in nutrition-reproduction interactions and their potential application as indicators of nutritional adequacy and predictors of reproductive performance in dairy cattle

    International Nuclear Information System (INIS)

    Blanche, Dominique

    2002-01-01

    Full text: The interaction between nutrition and reproductive activity has been described in both wild and farm animals. The lactating cow is one of the very best examples of this interaction. During lactation, the length of time spent in negative energy balance around parturition seems to be an important factor controlling the delay to return to breeding after parturition. The mechanism by which nutrition regulates the reproductive system is not fully understood in lactating dairy cows or indeed in any other situation in ruminants or mammals in general. However, to be effective, a nutritional signal should ultimately act on at least one of the 3 regulatory sites in the reproductive axis - the brain, the pituitary gland and the gonads. Nutrition is likely to involve metabolic signals that could act directly on one of these targets or it could interfere with other regulatory mechanisms such as the feedback by gonadal steroids on gonadotrophin secretion. In this presentation, we will use examples from laboratory rodents and ruminants, and from dairy cattle where they are available, to examine how IGF-1 and leptin, amongst several other blood metabolites and metabolic hormones, could be part of the link between nutrition and reproduction in the postpartum dairy cow. A number of studies have proposed a role for IGF-1 in the control of postpartum anoestrus and the framework of the current hypothesis will be presented. The role of leptin is still not clear for ruminants in general, but especially in cattle, because leptin was only recently discovered (about 6 years ago) and because a reliable radioimmunoassay for bovine leptin only became available since 1999. The possibilities and restrictions of a role for leptin in the control of reproduction by nutrition will be discussed. To conclude, we will examine the use of these two hormones as potential indicators of the adequacy of nutritional status for reproductive function and we will introduce insulin as another

  12. Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat

    International Nuclear Information System (INIS)

    Worley, Rachel Rogers; Fisher, Jeffrey

    2015-01-01

    ABSTRACT: Renal elimination and the resulting clearance of perfluorooctanoic acid (PFOA) from the serum exhibit pronounced sex differences in the adult rat. The literature suggests that this is largely due to hormonally regulated expression of organic anion transporters (OATs) on the apical and basolateral membranes of the proximal tubule cells that facilitate excretion and reabsorption of PFOA from the filtrate into the blood. Previously developed PBPK models of PFOA exposure in the rat have not been parameterized to specifically account for transporter-mediated renal elimination. We developed a PBPK model for PFOA in male and female rats to explore the role of Oat1, Oat3, and Oatp1a1 in sex-specific renal reabsorption and excretion of PFOA. Descriptions of the kinetic behavior of these transporters were extrapolated from in vitro studies and the model was used to simulate time-course serum, liver, and urine data for intravenous (IV) and oral exposures in both sexes. Model predicted concentrations of PFOA in the liver, serum, and urine showed good agreement with experimental data for both male and female rats indicating that in vitro derived physiological descriptions of transporter-mediated renal reabsorption can successfully predict sex-dependent excretion of PFOA in the rat. This study supports the hypothesis that sex-specific serum half-lives for PFOA are largely driven by expression of transporters in the kidney and contribute to the development of PBPK modeling as a tool for evaluating the role of transporters in renal clearance. - Highlights: • The PBPK model for PFOA in the rat explores the role of OATs in sex-specific clearance. • Descriptions of OAT kinetics were extrapolated from in vitro studies. • Model predictions showed good fit with experimental data for male and female rats.

  13. Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat

    Energy Technology Data Exchange (ETDEWEB)

    Worley, Rachel Rogers, E-mail: idz7@cdc.gov [Agency for Toxic Substances and Disease Registry, Division of Community Health Investigations, 4770 Buford Highway, Atlanta, GA 30341 (United States); Interdisciplinary Toxicology Program, University of Georgia, 341 Pharmacy South, Athens, GA 30602 (United States); Fisher, Jeffrey [Interdisciplinary Toxicology Program, University of Georgia, 341 Pharmacy South, Athens, GA 30602 (United States); Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079 (United States)

    2015-12-15

    ABSTRACT: Renal elimination and the resulting clearance of perfluorooctanoic acid (PFOA) from the serum exhibit pronounced sex differences in the adult rat. The literature suggests that this is largely due to hormonally regulated expression of organic anion transporters (OATs) on the apical and basolateral membranes of the proximal tubule cells that facilitate excretion and reabsorption of PFOA from the filtrate into the blood. Previously developed PBPK models of PFOA exposure in the rat have not been parameterized to specifically account for transporter-mediated renal elimination. We developed a PBPK model for PFOA in male and female rats to explore the role of Oat1, Oat3, and Oatp1a1 in sex-specific renal reabsorption and excretion of PFOA. Descriptions of the kinetic behavior of these transporters were extrapolated from in vitro studies and the model was used to simulate time-course serum, liver, and urine data for intravenous (IV) and oral exposures in both sexes. Model predicted concentrations of PFOA in the liver, serum, and urine showed good agreement with experimental data for both male and female rats indicating that in vitro derived physiological descriptions of transporter-mediated renal reabsorption can successfully predict sex-dependent excretion of PFOA in the rat. This study supports the hypothesis that sex-specific serum half-lives for PFOA are largely driven by expression of transporters in the kidney and contribute to the development of PBPK modeling as a tool for evaluating the role of transporters in renal clearance. - Highlights: • The PBPK model for PFOA in the rat explores the role of OATs in sex-specific clearance. • Descriptions of OAT kinetics were extrapolated from in vitro studies. • Model predictions showed good fit with experimental data for male and female rats.

  14. The role of intention as mediator between latent effects and behavior: application of a hybrid choice model to study departure time choices

    DEFF Research Database (Denmark)

    Thorhauge, Mikkel; Cherchi, Elisabetta; Walker, Joan L.

    2017-01-01

    of them consider the effect of intention and its role as mediator between those psychological effects and the choice, as implied in the Theory of Planned Behavior. In this paper we contribute to the literature in this field by specifically studying the direct effect of the intention on the actual behavior......, while attitude, social norms, and perceived behavioral control affect the intention to behave in a given way. We apply a hybrid choice model to study the departure time choice. For this, we use data from Danish commuters in the morning rush hours in the Greater Copenhagen area. We find a significant...

  15. Wapice News Mobile Application

    OpenAIRE

    Söylemez, Ilke

    2017-01-01

    Since the mobile phones started to have an increasingly significant role in daily life, the mobile application development also started to be an important area in the software industry. The problem for mobile application developers is to develop a mobile application which supports all the devices and platforms on the market. This issue created a need for cross platform mobile applications. The cross platform mobile development refers to the development of mobile applications that could be use...

  16. The role of cyclooxygenase-2 in the malignant tissue and possible applicability of cyclooxygenase-2 inhibitors in the therapy of cancer

    International Nuclear Information System (INIS)

    Legan, M.

    2003-01-01

    Cyclooxygenase-2 (COX-2), an inducible prostaglandin (PG) synthase, is elevated in many types of malignant and pre-malignant tissues. This enzyme is localized in neoplastic (epithelial) cells, microvascular endothelial cells, and stromal fibroblasts. Through the released PG it enhances carcinogenesis with increasing angiogenesis, inhibiting apoptosis, activating matrix metalloproteinases, suppressing of cell mediated antitumor immune response and protection against damage by cytotoxic agents. Evidences from in vitro studies, studies on animal models as well as first clinical outcomes suggest that the inhibition of COX-2 may suppress carcinogenesis by affecting a number of pathways: inhibiting angiogenesis, invasiveness of tumors and promoting apoptosis. References forecast that COX-2 inhibitors, mostly COX-2 selective inhibitors, may get a role in the therapy of cancer as an adjuvant therapy or as an co-chemotherapeutic agent. The purpose of the present article is to summarize the most important facts about the role of COX-2 in the malignant tissue and discuss possible ways for potential therapeutic place of COX-2 inhibitors in clinical practice. (author)

  17. High-tech tools for exercise motivation: use and role of technologies such as the internet, mobile applications, social media, and video games.

    Science.gov (United States)

    Tate, Deborah F; Lyons, Elizabeth J; Valle, Carmina G

    2015-01-01

    IN BRIEF The majority of patients with type 2 diabetes are not active at recommended levels, and many do not have access to behavior change programs to support lifestyle change. Thus, tools and programs designed to promote the adoption and maintenance of physical activity using technology may be helpful. This article reviews the evidence regarding the use of technology tools such as the Internet, mobile applications, social media, and video games and provides suggestions for evaluating the potential benefit of such tools for behavior change.

  18. Students as First-time Voters: The role of Voter Advice Applications in Self-reflection on Party Choice and Political Identity

    Directory of Open Access Journals (Sweden)

    Niels Nørgaard Kristensen

    2017-03-01

    Full Text Available Purpose: This article analyses what characterises first time voters' self-reflections on party choice as they use voter advice applications. Method: This study is based on interviews of 28 Norwegian students (age 18-20preparing themselves for their first election. Findings: Finding a party to vote for is primarily characterized by a process of matching a party to students' political self, which we see as steps toward a political identity. Practical implications: Teaching politics should allow for students' reflections on self and their political preferences.

  19. High-Tech Tools for Exercise Motivation: Use and Role of Technologies Such as the Internet, Mobile Applications, Social Media, and Video Games

    Science.gov (United States)

    Lyons, Elizabeth J.; Valle, Carmina G.

    2015-01-01

    IN BRIEF The majority of patients with type 2 diabetes are not active at recommended levels, and many do not have access to behavior change programs to support lifestyle change. Thus, tools and programs designed to promote the adoption and maintenance of physical activity using technology may be helpful. This article reviews the evidence regarding the use of technology tools such as the Internet, mobile applications, social media, and video games and provides suggestions for evaluating the potential benefit of such tools for behavior change. PMID:25717278

  20. The role of social cost-benefit analysis in societal decision-making under large uncertainties with application to robbery at a cash depot

    International Nuclear Information System (INIS)

    Jones-Lee, M.; Aven, T.

    2009-01-01

    Social cost-benefit analysis is a well-established method for guiding decisions about safety investments, particularly in situations in which it is possible to make accurate predictions of future performance. However, its direct applicability to situations involving large degrees of uncertainty is less obvious and this raises the question of the extent to which social cost-benefit analysis can provide a useful input to the decision framework that has been explicitly developed to deal with safety decisions in which uncertainty is a major factor, namely risk analysis. This is the main focus of the arguments developed in this paper. In particular, we provide new insights by examining the fundamentals of both approaches and our principal conclusion is that social cost-benefit analysis and risk analysis represent complementary input bases to the decision-making process, and even in the case of large uncertainties social cost-benefit analysis may provide very useful decision support. What is required is the establishment of a proper contextual framework which structures and gives adequate weight to the uncertainties. An application to the possibility of a robbery at a cash depot is examined as a practical example.

  1. Role of Bacillus licheniformis VS16-Derived Biosurfactant in Mediating Immune Responses in Carp Rohu and its Application to the Food Industry

    Science.gov (United States)

    Giri, Sib Sankar; Sen, Shib Sankar; Jun, Jin Woo; Sukumaran, V.; Park, Se Chang

    2017-01-01

    Multifarious applications of Bacillus licheniformis VS16-derived biosurfactant were explored. Labeo rohita fingerlings were injected intraperitoneally with 0.1 mL of phosphate-buffered saline (PBS) containing purified biosurfactant at 0 (control), 55 (S55), 110 (S110), 220 (S220), or 330 (S330) μg mL-1 concentrations. Various immunological parameters and the expression of immune-related genes were measured at 7, 14, and 21 days post-administration (dpa). At 21 dpa, fish were challenged with Aeromonas hydrophila and mortality was recorded for 14 days. Immune parameters such as lysozyme levels (39.29 ± 2.14 U mL-1), alternative complement pathway (61.21 ± 2.38 U mL-1), and phagocytic activities (33.37 ± 1.2%) were maximum (P Biosurfactant was effective in inhibiting biofilm formation up to 54.71 ± 1.27%. Moreover, it efficiently removed cadmium (Cd) from tested vegetables such as carrot, radish, ginger, and potato, with the highest removal efficiency (60.98 ± 1.29%) recorded in ginger contaminated with Cd. Collectively, these results suggest that isolated biosurfactant could be used in the aquaculture industry, in addition to its potential application to the food industry. PMID:28400765

  2. Climate change and the health of older people in Australia: A scoping review on the role of mobile applications (apps) in ameliorating impact.

    Science.gov (United States)

    Black, Deborah A; O'Loughlin, Kate; Wilson, Leigh A

    2018-06-01

    Due to the impact of climate change, mobile applications (apps) providing information about the external environment have the potential to improve the health of older people. The purpose of this research was to undertake a scoping review of the evidence on the usability, feasibility and effectiveness of mobile apps to encourage access to activities outside the home in older people. A search of databases was undertaken with relevant keywords. Selected manuscripts were judged for relevance to the inclusion criteria and assessed for quality. Very few published studies examined mobile apps specifically designed to prevent, or to treat, chronic disease in ageing populations, and fewer had rigorous designs. No study addressed accessing the external environment in the context of climate change. This study demonstrates that there is a gap in the evidence about the mobile apps designed for healthy ageing and, more specifically, to improve access to the external environment. © 2018 AJA Inc.

  3. Le Sommeil et l’Age: de la Physiopathologie a la Therapeutique (Sleep and Age: From Physiopathology to Therapeutics)

    Science.gov (United States)

    2000-08-01

    comine ront montrd Blois et diflicile. al. en 1983 et Boselli et al. en 1998: - Causes et m&anismes PARAMETRE VARIATION Le rythme veille-sonuneil est...nocturnes BENOIT 0. Troubles du rythnie veille-sommeil. La revue Pourcentage de stade 2 du praticien, 1996,46,2442-2447. Pourcentage de stades 3 et 4 BLOIS R_...appears even the age of 35-40 years as it was demonsrated bywithe a. n193 aging, ea! n 99 On the other hand, psychostimulants could reduce Blois etal. in

  4. Role of Ni2+(d8) ions in electrical, optical and magnetic properties of CdS nanowires for optoelectronic and spintronic applications

    Science.gov (United States)

    Arshad Kamran, Muhammad

    2018-06-01

    For the first time, 1D Ni ion doped CdS nanowires (NWs) were synthesized via chemical vapour deposition (CVD). The synthesized Cd0.886Ni0.114S NWs were single crystalline. We have reported here the investigation of optical, electrical and magnetic properties of prepared NWs for optoelectronic and spintronic applications. Successful incorporation of Ni ions in an individual CdS NW has been confirmed through several characterization tools: significantly higher angle and phonon mode shift were observed in the XRD and Raman spectra. SEM-EDX and XPS analysis also confirmed the presence of Ni2+ ions. Room temperature photoluminescence (RT-PL) showed multiple peaks: two emission peaks in the visible region centered at 517.1 nm (green), 579.2 nm (orange), and a broad-band near infra-red (NIR) emission centered at 759.9 nm. The first peak showed 5 nm red shift upon Ni2+ doping, hinting at the formation of exciton magnetic polarons (EMPs), and broad NIR emission was observed in both chlorides and bromides, which was assigned to d‑d transition of Ni ions whose energy levels lying at 749.51 nm (13 342 cm–1) and 750.98 nm (13 316 cm–1) are very close to NIR emission. Orange emission not only remained at same peak position—its PL intensity was also significantly enhanced at 78 K; this was assigned to d‑d transition (3A2g → 1Eg) of Ni2+ ions. It was observed that 11.4% Ni2+ ion doping enhanced the conductivity of our sample around 20 times, and saturation magnetization (Ms) increased from 7.2 × 10‑5 Am2/Kg to 1.17 × 10‑4 Am2/Kg, which shows promise for optoelectronic and spintronic applications.

  5. The role of the gas/plasma plume and self-focusing in a gas-filled capillary discharge waveguide for high-power laser-plasma applications

    CERN Document Server

    Ciocarlan, C.; Islam, M. R.; Ersfeld, B.; Abuazoum, S.; Wilson, R.; Aniculaesei, C.; Welsh, G. H.; Vieux, G.; Jaroszynski, D. A.; 10.1063/1.4822333

    2013-01-01

    The role of the gas/plasma plume at the entrance of a gas-filled capillary discharge plasma waveguide in increasing the laser intensity has been investigated. Distinction is made between neutral gas and hot plasma plumes that, respectively, develop before and after discharge breakdown. Time-averaged measurements show that the on-axis plasma density of a fully expanded plasma plume over this region is similar to that inside the waveguide. Above the critical power, relativistic and ponderomotive selffocusing lead to an increase in the intensity, which can be nearly a factor of 2 compared with the case without a plume. When used as a laser plasma wakefield accelerator, the enhancement of intensity can lead to prompt electron injection very close to the entrance of the waveguide. Self-focusing occurs within two Rayleigh lengths of the waveguide entrance plane in the region, where the laser beam is converging. Analytical theory and numerical simulations show that, for a density of 3.01018 cm3, the peak normalized...

  6. Russian olive (Elaeagnus angustifolia L.: From a variety of traditional medicinal applications to its novel roles as active antioxidant, anti-inflammatory, anti-mutagenic and analgesic agent

    Directory of Open Access Journals (Sweden)

    Rafie Hamidpour

    2017-01-01

    Full Text Available Elaeagnus angustifolia L., which is commonly known as oleaster or Russian olive, is a deciduous plant from Elaeagnacea family. This plant can tolerate and survive a wide variety of environmental conditions. Different parts of E. angustifolia plant, especially the fruits and flowers, have been used traditionally in treating a variety of common illnesses such as nausea, cough, asthma, fever, jaundice, and diarrhea. The use of fruit powder and extract of E. angustifolia L. have shown to be effective in alleviating pain in patients with rheumatoid arthritis and also in reducing the healing time of wounds in injured person. In addition, some recent reports have indicated the anti-oxidant, anti-inflammatory, antimicrobial, anticancer and some other properties of oleaster plant. The other important property of this plant would be its role in bio-monitoring the environment for some toxic elements and also its action as a bio-fertilizer agent in distressed lands. It seems that with more advanced studies on E. angustifolia L. and its bioactive components, this plant might be potentially effective and can be used as a natural alternative resource in pharmaceutical industries for treating chronic and serious problems, Fig. 1.

  7. Role and assignments of a consultant for the evaluation and the construction of a nuclear power plant application to a project in Turkey

    International Nuclear Information System (INIS)

    Naigeon, J.; Menez, A.; Valentin, A.; Milliot, B.; Kutukcuoglu, A.; Sahin, S.

    1977-01-01

    For certain countries, the decision to build the first nuclear power plant raises serious problems, generally through lack of a sufficient number of specialists and of adequate experience to overcome the difficulties involved. The role of a consultant consists in making his knowledge and experience available to the future power plant owner, thus enabling him to make adequate and timely decisions and to build and operate the facility under optimum conditions. The consultant's assignments are determined case by case. Generally speaking, they concern the following aspects: specific site investigations; preparation of the invitations to bid and bid evaluation; preparation of the final project; technical assistance throughout the manufacture of the equipment, the construction and the erection stages and also during the plant acceptance and start-up tests; and safety analysis and participation in the preparation of the corresponding reports. To these assignments are added, where necessary, complementary studies such as: investigation of the problems involved in fuel procurement, management, storage and (or) reprocessing; cost estimation and financial planning; and definition of operating staff training requirements. At the outset, the future owner may also request advice as to the type of plant to adopt. All these aspects are analyzed in the light of the experience acquired during the performance of a contract, presently underway for the preparation of an invitation to bid for the construction of the first nuclear power plant (600 MWe) to be ordered by a national electricity utility [fr

  8. Smoking behaviors and intentions among adolescents in rural China: the application of the Theory of Planned Behavior and the role of social influence.

    Science.gov (United States)

    Su, Xuefen; Li, Liping; Griffiths, Sian M; Gao, Yang; Lau, Joseph T F; Mo, Phoenix K H

    2015-09-01

    This study investigated the associations between the variables of the theory of planned behavior (TPB), influence of significant others, and smoking intentions and behaviors among adolescents living in rural southern China. A cross-sectional study was conducted among 2609 students in two junior high schools in rural Shantou, Guangdong province, using a self-administered questionnaire. Logistic regression models were fitted to estimate univariate and adjusted odds ratios and corresponding 95% confidence intervals. Multivariate analyses showed that having favorable attitudes towards smoking on psychological and social aspects, perceived behavioral control, and having most friends who were current smokers were significantly associated with smoking intentions in the next six months and in the next five years. Having most family members who were current smokers was also significantly related to smoking intention in the next five years. Having favorable attitudes towards smoking on psychological aspect and negative attitudes on physical aspect, perceived support from friends on smoking, and having most friends and senior relatives being current smokers were significantly associated with increased likelihood of ever smoking. Perceived behavioral control and having most friends being current smokers were also significantly associated with regular smoking and smoking in the past 30days. Our results suggest that the key constructs of the TPB model and friends' smoking behaviors play important roles in accounting for smoking intentions and behaviors among a sample of rural Chinese adolescents. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Role Identification and Application of SigD in the Transformation of Soybean Phytosterol to 9α-Hydroxy-4-androstene-3,17-dione in Mycobacterium neoaurum.

    Science.gov (United States)

    Xiong, Liang-Bin; Liu, Hao-Hao; Xu, Li-Qin; Wei, Dong-Zhi; Wang, Feng-Qing

    2017-01-25

    9α-Hydroxy-4-androstene-3,17-dione (9-OHAD) is a valuable steroid pharmaceutical intermediate which can be produced by the conversion of soybean phytosterols in mycobacteria. However, the unsatisfactory productivity and conversion efficiency of engineered mycobacterial strains hinder their industrial applications. Here, a sigma factor D (sigD) was investigated due to its dramatic downregulation during the conversion of phytosterols to 9-OHAD. It was determined as a negative regulator in the metabolism of phytosterols, and the deletion of sigD in a 9-OHAD-producing strain significantly enhanced the titer of 9-OHAD by 18.9%. Furthermore, a high yielding strain was constructed by the combined modifications of sigD and choM2, a key gene in the phytosterol metabolism pathway. After the modifications, the productivity of 9-OHAD reached 0.071 g/L/h (10.27 g/L from 20 g/L phytosterol), which was 22.5% higher than the original productivity of 0.058 g/L/h (8.37 g/L from 20 g/L phytosterol) in the industrial resting cell biotransformation system.

  10. Thermo-enhanced field emission from ZnO nanowires: Role of defects and application in a diode flat panel X-ray source

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Zhipeng; Chen, Daokun; Chen, Wenqing; Chen, Yicong; Song, Xiaomeng; Zhan, Runze; Deng, Shaozhi; Xu, Ningsheng; Chen, Jun, E-mail: stscjun@mail.sysu.edu.cn

    2017-03-31

    Highlights: • A thermo-enhanced field emission phenomenon was observed from dendritic ZnO nanowires under the temperature of 323–723 K. • Defect-assisted field emission mechanism was proposed and quantitative calculation fits well with the experiment results. • The mechanism was verified by the field emission from ZnO nanowires with different defect concentrations. • A diode X-ray source making use of thermo-enhanced field emission phenomenon was proposed for separate tuning of dose and energy. - Abstract: A thermo-enhanced field emission phenomenon was observed from ZnO nanowires. The field emission current increased by almost two orders of magnitude under a constant applied electric field, and the turn-on field decreased from 6.04 MV/m to 5.0 MV/m when the temperature increased from 323 to 723 K. The Poole–Frenkel electron excitation from the defect-induced trapping centers to the conduction band under high electric fields is believed to be the primary cause of the observed phenomenon. The experimental results fit well with the proposed physical model. The field emission from ZnO nanowires with different defect concentrations further confirmed the role of defects. Using the thermo-enhanced field emission phenomenon, a diode flat panel X-ray source was demonstrated, for which the energy and dose can be separately tuned. The thermo-enhanced field emission phenomenon observed from ZnO nanowires could be an effective way to realize a large area flat panel multi-energy X-ray source.

  11. The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction

    Directory of Open Access Journals (Sweden)

    Francisco-Javier Bermúdez-Silva

    2011-08-01

    Full Text Available The endocannabinoid system (ECS has been implicated in many physiological functions, including the regulation of appetite, food intake and energy balance, a crucial involvement in brain reward systems and a role in psychophysiological homeostasis (anxiety and stress responses. We first introduce this important regulatory system and chronicle what is known concerning the signal transduction pathways activated upon the binding of endogenous cannabinoid ligands to the Gi/0-coupled CB1 cannabinoid receptor, as well as its interactions with other hormones and neuromodulators which can modify endocannabinoid signaling in the brain. Anorexia nervosa (AN and bulimia nervosa (BN are severe and disabling psychiatric disorders, characterized by profound eating and weight alterations and body image disturbances. Since endocannabinoids modulate eating behavior, it is plausible that endocannabinoid genes may contribute to the biological vulnerability to these diseases. We present and discuss data suggesting an impaired endocannabinoid signaling in these eating disorders, including association of endocannabinoid components gene polymorphisms and altered CB1-receptor expression in AN and BN. Then we discuss recent findings that may provide new avenues for the identification of therapeutic strategies based on the endocannabinod system. In relation with its implications as a reward-related system, the endocannabinoid system is not only a target for cannabis but it also shows interactions with other drugs of abuse. On the other hand, there may be also a possibility to point to the ECS as a potential target for treatment of drug-abuse and addiction. Within this framework we will focus on enzymatic machinery involved in endocannabinoid inactivation (notably fatty acid amide hydrolase or FAAH as a particularly interesting potential target. Since a deregulated endocannabinoid system may be also related to depression, anxiety and pain symptomatology accompanying drug

  12. Role of temperature in the radiation stability of yttria stabilized zirconia under swift heavy ion irradiation: A study from the perspective of nuclear reactor applications

    Science.gov (United States)

    Kalita, Parswajit; Ghosh, Santanu; Sattonnay, Gaël; Singh, Udai B.; Grover, Vinita; Shukla, Rakesh; Amirthapandian, S.; Meena, Ramcharan; Tyagi, A. K.; Avasthi, Devesh K.

    2017-07-01

    The search for materials that can withstand the harsh radiation environments of the nuclear industry has become an urgent challenge in the face of ever-increasing demands for nuclear energy. To this end, polycrystalline yttria stabilized zirconia (YSZ) pellets were irradiated with 80 MeV Ag6+ ions to investigate their radiation tolerance against fission fragments. To better simulate a nuclear reactor environment, the irradiations were carried out at the typical nuclear reactor temperature (850 °C). For comparison, irradiations were also performed at room temperature. Grazing incidence X-ray diffraction and Raman spectroscopy measurements reveal degradation in crystallinity for the room temperature irradiated samples. No bulk structural amorphization was however observed, whereas defect clusters were formed as indicated by transmission electron microscopy and supported by thermal spike simulation results. A significant reduction of the irradiation induced defects/damage, i.e., improvement in the radiation tolerance, was seen under irradiation at 850 °C. This is attributed to the fact that the rapid thermal quenching of the localized hot molten zones (arising from spike in the lattice temperature upon irradiation) is confined to 850 °C (i.e., attributed to the resistance inflicted on the rapid thermal quenching of the localized hot molten zones by the high temperature of the environment) thereby resulting in the reduction of the defects/damage produced. Our results present strong evidence for the applicability of YSZ as an inert matrix fuel in nuclear reactors, where competitive effects of radiation damage and dynamic thermal healing mechanisms may lead to a strong reduction in the damage production and thus sustain its physical integrity.

  13. Promoting Implementation of Safety Culture in Nuclear Application for Industrial Facilities; an Important Role of Nuclear Energy Regulatory Agency in Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    Setianingsih, Lilis Susanti [KINS-KAIST Master Degree Program, Daejeon (Korea, Republic of)

    2012-03-15

    Implementation of nuclear energy for industrial purposes has reached its highest peak. BAPETEN, as Nuclear Energy Regulatory Agency of Indonesia has published regulations regarding nuclear energy utilization. As high risk associating such utilization requires direct and thoroughly supervision in order to assure its compliance to safety and security aspect, procedures related to operational activities must by fully applied. Radiation Protection Program as one type of procedures that must be available in nuclear energy utilization operation is intended to provide operators specifically technical guidance to avoid undesired negative effects of incidents or accidents. It is the responsibility of managerial level in a company to provide the procedures and to further supervise their application in the field. Radiation workers, those are all employees working in or within radiation area must understand how to execute the procedures properly. The radiation protection program is intended to protect workers, member of community and property as well as the environment from the negative impacts of nuclear utilization operational due to its radiation exposure. Safety culture, a compound of nature derived from behavior of organization and people within the organization to pay a full attention and give main priority in radiation safety matters, is expected to be achieved by implementing the radiation protection program as safety habits at the work place. It requires a management commitment to ensure that all aspect in safety and, whenever necessary, security are accomplished within the radiation protection program in order to build a safety culture in a radiation work place. Government Regulation No. 33 2007 about Safety for Ionizing Radiation and Security for Radioactive Source and Government Regulation No. 29 2008 regarding Licensing for Utilization of Ionizing Radiation and Nuclear Material present regulation and arrangement related to radiation protection program as a basic

  14. Promoting Implementation of Safety Culture in Nuclear Application for Industrial Facilities; an Important Role of Nuclear Energy Regulatory Agency in Indonesia

    International Nuclear Information System (INIS)

    Setianingsih, Lilis Susanti

    2012-01-01

    Implementation of nuclear energy for industrial purposes has reached its highest peak. BAPETEN, as Nuclear Energy Regulatory Agency of Indonesia has published regulations regarding nuclear energy utilization. As high risk associating such utilization requires direct and thoroughly supervision in order to assure its compliance to safety and security aspect, procedures related to operational activities must by fully applied. Radiation Protection Program as one type of procedures that must be available in nuclear energy utilization operation is intended to provide operators specifically technical guidance to avoid undesired negative effects of incidents or accidents. It is the responsibility of managerial level in a company to provide the procedures and to further supervise their application in the field. Radiation workers, those are all employees working in or within radiation area must understand how to execute the procedures properly. The radiation protection program is intended to protect workers, member of community and property as well as the environment from the negative impacts of nuclear utilization operational due to its radiation exposure. Safety culture, a compound of nature derived from behavior of organization and people within the organization to pay a full attention and give main priority in radiation safety matters, is expected to be achieved by implementing the radiation protection program as safety habits at the work place. It requires a management commitment to ensure that all aspect in safety and, whenever necessary, security are accomplished within the radiation protection program in order to build a safety culture in a radiation work place. Government Regulation No. 33 2007 about Safety for Ionizing Radiation and Security for Radioactive Source and Government Regulation No. 29 2008 regarding Licensing for Utilization of Ionizing Radiation and Nuclear Material present regulation and arrangement related to radiation protection program as a basic

  15. Characterization of C-S lyase from Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 and its potential role in food flavour applications.

    Science.gov (United States)

    Allegrini, Alessandra; Astegno, Alessandra; La Verde, Valentina; Dominici, Paola

    2017-04-01

    Volatile thiols have substantial impact on the aroma of many beverages and foods. Thus, the control of their formation, which has been linked to C-S lyase enzymatic activities, is of great significance in industrial applications involving food flavours. Herein, we have carried out a spectroscopic and functional characterization of a putative pyridoxal 5'-phosphate (PLP)-dependent C-S lyase from the lactic acid bacterium Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 (LDB C-S lyase). Recombinant LDB C-S lyase exists as a tetramer in solution and shows spectral properties of enzymes containing PLP as cofactor. The enzyme has a broad substrate specificity toward sulphur-containing amino acids with aminoethyl-L-cysteine and L-cystine being the most effective substrates over L-cysteine and L-cystathionine. Notably, the protein also reveals cysteine-S-conjugate β-lyase activity in vitro, and is able to cleave a cysteinylated substrate precursor into the corresponding flavour-contributing thiol, with a catalytic efficiency higher than L-cystathionine. Contrary to similar enzymes of other lactic acid bacteria however, LDB C-S lyase is not capable of α,γ-elimination activity towards L-methionine to produce methanethiol, which is a significant compound in flavour development. Based on our results, future developments can be expected regarding the flavour-forming potential of Lactobacillus C-S lyase and its use in enhancing food flavours. © The Authors 2017. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

  16. The role of bismuth on the microstructure and corrosion behavior of ternary Mg–1.2Ca–xBi alloys for biomedical applications

    Energy Technology Data Exchange (ETDEWEB)

    Tok, H.Y.; Hamzah, E., E-mail: Esah@fkm.utm.my; Bakhsheshi-Rad, H.R.

    2015-08-15

    Highlights: • Secondary phases have a significant effect on corrosion properties of the alloys. • Microstructure of Mg–Ca–xBi was refined significantly after Bi addition. • Addition of 0.5 wt.% Bi to Mg–Ca alloy leads to increase corrosion resistance. • Microstructure analysis showed needle-shaped precipitates at the grain boundaries. - Abstract: In this study the influence of various Bi additions on the microstructure and corrosion behavior of the Mg–1.2Ca–xBi alloys (x = 0.5, 1.5, 3, 5, 12 wt.%) were evaluated by using optical and scanning electron microscopy, immersion and electrochemical tests. Microstructural observations showed that the refinement efficiency became more pronounced with increased Bi amount. Microstructural results of Mg–1.2Ca–xBi (x = 0.5, 1.5, and 3) indicated that the formation of three distinct phases—namely α-Mg, Mg{sub 2}Ca and Mg{sub 3}Bi{sub 2}. However, further addition of Bi to 5 and 12 wt.% leads to evolution of α-Mg, Mg{sub 3}Bi{sub 2}, and Mg{sub 2}Bi{sub 2}Ca phases. The addition of Bi up to 0.5 wt.% enhanced corrosion resistance while further addition from 1.5 to 12 wt.% accelerated the degradation rate because of the emergence of more galvanic coupling between the α-Mg phases and secondary phases. The analyses showed that the Mg–1.2Ca–0.5Bi alloy gives the best corrosion resistance behavior, which makes it ideal for biodegradable medical applications.

  17. The role of post-failure brittleness of soft rocks in the assessment of stability of intact masses: FDEM technique applications to ideal problems

    Science.gov (United States)

    Lollino, Piernicola; Andriani, Gioacchino Francesco; Fazio, Nunzio Luciano; Perrotti, Michele

    2016-04-01

    Strain-softening under low confinement stress, i.e. the drop of strength that occurs in the post-failure stage, represents a key factor of the stress-strain behavior of rocks. However, this feature of the rock behavior is generally underestimated or even neglected in the assessment of boundary value problems of intact soft rock masses. This is typically the case when the stability of intact rock masses is treated by means of limit equilibrium or finite element analyses, for which rigid-plastic or elastic perfectly-plastic constitutive models, generally implementing peak strength conditions of the rock, are respectively used. In fact, the aforementioned numerical techniques are characterized by intrinsic limitations that do not allow to account for material brittleness, either for the method assumptions or due to numerical stability problems, as for the case of the finite element method, unless sophisticated regularization techniques are implemented. However, for those problems that concern the stability of intact soft rock masses at low stress levels, as for example the stability of shallow underground caves or that of rock slopes, the brittle stress-strain response of rock in the post-failure stage cannot be disregarded due to the risk of overestimation of the stability factor. This work is aimed at highlighting the role of post-peak brittleness of soft rocks in the analysis of specific ideal problems by means of the use of a hybrid finite-discrete element technique (FDEM) that allows for the simulation of the rock stress-strain brittle behavior in a proper way. In particular, the stability of two ideal cases, represented by a shallow underground rectangular cave and a vertical cliff, has been analyzed by implementing a post-peak brittle behavior of the rock and the comparison with a non-brittle response of the rock mass is also explored. To this purpose, the mechanical behavior of a soft calcarenite belonging to the Calcarenite di Gravina formation, extensively

  18. The role of hydrological and water quality models in the application of the ecosystem services framework for the EU Water Framework Directive

    Science.gov (United States)

    Hallouin, Thibault; Bruen, Michael; Feeley, Hugh B.; Christie, Michael; Bullock, Craig; Kelly, Fiona; Kelly-Quinn, Mary

    2017-04-01

    The hydrological cycle is intimately linked with environmental processes that are essential for human welfare in many regards including, among others, the provision of safe water from surface and subsurface waterbodies, rain-fed agricultural production, or the provision of aquatic-sourced food. As well as being a receiver of these natural benefits, the human population is also a manager of the water and other natural resources and, as such, can affect their future sustainable provision. With global population growth and climate change, both the dependence of the human population on water resources and the threat they pose to these resources are likely to intensify so that the sustainability of the coupled natural and human system is threatened. In the European Union, the Water Framework Directive is driving policy and encouraging member states to manage their water resources wisely in order to maintain or restore ecological quality. To this end, the ecosystem services framework can be a useful tool to link the requirements in terms of ecological status into more tangible descriptors, that is the ecosystem services. In the ESManage Project, existing environmental system models such as hydrological models and water quality models are used as the basis to quantify the provision of many hydrological and aquatic ecosystem services by constructing indicators for the ecosystem services from the modelled environmental variables. By allowing different management options and policies to be compared, these models can be a valuable source of information for policy makers when they are used for climate and land use scenario analyses. Not all hydrological models developed for flood forecasting are suitable for this application and inappropriate models can lead to questionable conclusions. This paper demonstrates the readily available capabilities of a specially developed catchment hydrological model coupled with a water quality model to quantify a wide range of biophysically

  19. Quantifying the role of climate variability on extreme total water level impacts: An application of a full simulation model to Ocean Beach, California

    Science.gov (United States)

    Serafin, K.; Ruggiero, P.; Stockdon, H. F.; Barnard, P.; Long, J.

    2014-12-01

    Many coastal communities worldwide are vulnerable to flooding and erosion driven by extreme total water levels (TWL), potentially dangerous events produced by the combination of large waves, high tides, and high non-tidal residuals. The West coast of the United States provides an especially challenging environment to model these processes due to its complex geological setting combined with uncertain forecasts for sea level rise (SLR), changes in storminess, and possible changes in the frequency of major El Niños. Our research therefore aims to develop an appropriate methodology to assess present-day and future storm-induced coastal hazards along the entire U.S. West coast, filling this information gap. We present the application of this framework in a pilot study at Ocean Beach, California, a National Park site within the Golden Gate National Recreation Area where existing event-scale coastal change data can be used for model calibration and verification. We use a probabilistic, full simulation TWL model (TWL-FSM; Serafin and Ruggiero, in press) that captures the seasonal and interannual climatic variability in extremes using functions of regional climate indices, such as the Multivariate ENSO index (MEI), to represent atmospheric patterns related to the El Niño-Southern Oscillation (ENSO). In order to characterize the effect of climate variability on TWL components, we refine the TWL-FSM by splitting non-tidal residuals into low (monthly mean sea level anomalies) and high frequency (storm surge) components. We also develop synthetic climate indices using Markov sequences to reproduce the autocorrelated nature of ENSO behavior. With the refined TWL-FSM, we simulate each TWL component, resulting in synthetic TWL records providing robust estimates of extreme return level events (e.g., the 100-yr event) and the ability to examine the relative contribution of each TWL component to these extreme events. Extreme return levels are then used to drive storm impact models

  20. The role of the expert

    International Nuclear Information System (INIS)

    Smeesters, P.

    1998-01-01

    The expert's role in the involvement in decisions on nuclear risks is discussed. The responsibility of scientists in ethics and in several sociological problems is highlighted. The mandates, the positivist reaction, way to knowledge, the scientist as a subject studying an object, and application in the domain of radioprotection are the main issues of the somewhat philosophical essay. (R.P.)

  1. The role

    Directory of Open Access Journals (Sweden)

    Suresh Vellaiyan

    2016-09-01

    Full Text Available Air pollution caused by the diesel engines has shown much interest in the domain of eco-friendly diesel fuels since enhanced environmental and human health are of concern. In order to obtain the efficient energy development with less polluted environment with existing diesel engines, continuous efforts have gone into research and development of water-in-diesel (W/D emulsion fuels, which have the potential to reduce nitric oxides (NOx and particulate matter (PM emissions simultaneously with improved performance level. The current discussion addresses the principle of W/D emulsion fuel, emulsion fuel stability, physico-chemical properties and effect of W/D emulsion fuel on combustion, performance and emission characteristics. In addition, role of nano-additives in W/D emulsion fuel, nano-fuel synthesis and its influence on engine performance and emission characteristics are also discussed. The survey of earlier reports led to the decision that the optimization of engine parameters, nano-particle size confirmation in nano-fuel and its handling from engine exhaust are the details to be studied in the domain of W/D emulsion fuel engine.

  2. The role of PSA in safety management

    International Nuclear Information System (INIS)

    Szikszai, T.

    1997-01-01

    The presentation discusses the following issues: defence in depth principle (the role of the barriers, how does PSA represents the barriers?); the safety management and nuclear power plants; the probabilistic and deterministic approaches; the PSA applications and safety management

  3. Application of expert systems

    Energy Technology Data Exchange (ETDEWEB)

    Basden, A

    1983-11-01

    This article seeks to bring together a number of issues relevant to the application of expert systems by discussing their advantages and limitations, their roles and benefits, and the influence that real-life applications might have on the design of expert systems software. Part of the expert systems strategy of one major chemical company is outlined. Because it was in constructing one particular expert system that many of these issues became important this system is described briefly at the start of the paper and used to illustrate much of the later discussion. It is of the plausible-inference type and has application in the field of materials engineering. 22 references.

  4. A new class of medicament: radioactivity isotopes (1962); Une nouvelle classe de medicaments: les isotopes radioactifs (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Y. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    Very many radioelement are used in medicine, either for diagnosis or as therapeutics. The development of medicine has entailed an increase in the number of application of radioactive isotopes. Firstly used in the form of simple inorganic molecules for diagnosis or as anticancer therapeutics, radioelements are now used for labelling organic molecules, allowing functional specific studies of any kind of nature. Their production is made difficult by their radio-active properties. Their pharmaceutical properties, determined by tests and controls, depend either from radiochemistry and from medicine. The author reminds, in this report, the methods for the preparation and analysis, and set out the medical application. (author) [French] De tres nombreux radioelements trouvent une application en medecine humaine, soit dans le diagnostic, soit en therapeutique. L'evolution de la medecine entraine un accroissement du champ d'application des isotopes radioactifs. D'abord utilises sous forme de molecules minerales simples, pour les diagnostics ou des therapeutiques anticancereuses, les radioelements sont maintenant introduits dans des molecules organiques qui permettent des etudes fonctionnelles specifiques de toute nature. Leur fabrication est compliquee par leurs proprietes radioactives. Leurs caracteristiques pharmaceutiques determinees par des essais et controles, sont liees d'une part a la radiochimie, d'autre part a la medecine. L'auteur rappelle, dans cet expose, les methodes de preparation et d'analyse et aborde les applications medicales. (auteur)

  5. A new class of medicament: radioactivity isotopes (1962); Une nouvelle classe de medicaments: les isotopes radioactifs (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Y [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-07-01

    Very many radioelement are used in medicine, either for diagnosis or as therapeutics. The development of medicine has entailed an increase in the number of application of radioactive isotopes. Firstly used in the form of simple inorganic molecules for diagnosis or as anticancer therapeutics, radioelements are now used for labelling organic molecules, allowing functional specific studies of any kind of nature. Their production is made difficult by their radio-active properties. Their pharmaceutical properties, determined by tests and controls, depend either from radiochemistry and from medicine. The author reminds, in this report, the methods for the preparation and analysis, and set out the medical application. (author) [French] De tres nombreux radioelements trouvent une application en medecine humaine, soit dans le diagnostic, soit en therapeutique. L'evolution de la medecine entraine un accroissement du champ d'application des isotopes radioactifs. D'abord utilises sous forme de molecules minerales simples, pour les diagnostics ou des therapeutiques anticancereuses, les radioelements sont maintenant introduits dans des molecules organiques qui permettent des etudes fonctionnelles specifiques de toute nature. Leur fabrication est compliquee par leurs proprietes radioactives. Leurs caracteristiques pharmaceutiques determinees par des essais et controles, sont liees d'une part a la radiochimie, d'autre part a la medecine. L'auteur rappelle, dans cet expose, les methodes de preparation et d'analyse et aborde les applications medicales. (auteur)

  6. Nonlinear Optics and Applications

    Science.gov (United States)

    Abdeldayem, Hossin A. (Editor); Frazier, Donald O. (Editor)

    2007-01-01

    Nonlinear optics is the result of laser beam interaction with materials and started with the advent of lasers in the early 1960s. The field is growing daily and plays a major role in emerging photonic technology. Nonlinear optics play a major role in many of the optical applications such as optical signal processing, optical computers, ultrafast switches, ultra-short pulsed lasers, sensors, laser amplifiers, and many others. This special review volume on Nonlinear Optics and Applications is intended for those who want to be aware of the most recent technology. This book presents a survey of the recent advances of nonlinear optical applications. Emphasis will be on novel devices and materials, switching technology, optical computing, and important experimental results. Recent developments in topics which are of historical interest to researchers, and in the same time of potential use in the fields of all-optical communication and computing technologies, are also included. Additionally, a few new related topics which might provoke discussion are presented. The book includes chapters on nonlinear optics and applications; the nonlinear Schrodinger and associated equations that model spatio-temporal propagation; the supercontinuum light source; wideband ultrashort pulse fiber laser sources; lattice fabrication as well as their linear and nonlinear light guiding properties; the second-order EO effect (Pockels), the third-order (Kerr) and thermo-optical effects in optical waveguides and their applications in optical communication; and, the effect of magnetic field and its role in nonlinear optics, among other chapters.

  7. Role of Puspati

    Energy Technology Data Exchange (ETDEWEB)

    Muslim, N B

    1981-01-01

    The seminar is the third in a series of four seminars on the applications of nuclear techniques in industry and were organized by Pusat Penyelidikan Aatom Tun Ismail (PUSPATI) with the objective to introduce nuclear science and technology to Malaysia. PUSPATI was formed in 1972 aimed at five major areas of research programs to meet long-term objectives: 1) nuclear instrumentation and semiconductor technology, 2) uranium and thorium studies, 3) radiation chemistry and radiation biology, 4) reactor systems and energy studies, and 5) siting and safety studies of nuclear installations. The paper discusses the efforts in each of the above categories and draws attention to the services which PUSPATI plans to provide. The role of PUSPATI in industry and plans for future are also discussed.

  8. AINSE's future role

    International Nuclear Information System (INIS)

    MacDonald, R.J.

    1999-01-01

    AINSE (Australian Institute for Nuclear Science and Engineering) was created in 1958 as a consortium of nine universities and the then Australian Atomic Energy Commission (AAEC) to develop research projects associated with the use of atomic energy. In 1999 AINSE remains strong, but has increased its membership to include 35 Australian universities and 1 New Zealand university. AINSE's role has been to facilitate access by researchers in universities to the facilities of the ANSTO Laboratories. Over the years the emphasis of the research projects themselves has shifted from those related to nuclear physics and the solution of problems associated with the development of nuclear energy, to projects where the emphasis is on the application of nuclear and nuclear related techniques to problems in a wide range of areas, including biomedical science and the environment. AINSE has reached a 40-year milestone and is about to enter the next millennium (and the next 40 years) at a time when ANSTO will host a new and modern reactor and the application of basic sciences to the biological areas is tipped to become the major focus of scientific discovery. Increasingly the environment becomes a source of major concern for everyone and the subject of a large component of research. The challenge for AINSE is to retain existing interests and expertise, but to also develop new ways in which nuclear science can be applied to these exciting and expanding areas of research

  9. Bilgi Okuryazarlığı Becerilerinin Geliştirilmesinde Kütüphanelerin Rolü ve Dokuz Eylül Üniversitesi Uygulaması / The Role of Libraries in the Development Information Literacy Skills and Application of Dokuz Eylül University

    Directory of Open Access Journals (Sweden)

    Ömür Saatçioğlu

    2003-04-01

    Full Text Available One of the areas where the impact of rapid change and developments most is the university education and libraries. Especially, technological development is one of the most important factors that affect the restructuring of university education and libraries. The skills that should be obtained throughout the university education carry the outmost importance in the restructuring process. One of these skills, which will make the major contribution to lifelong learning and learning how to learn, is information literacy. The role of library and librarians are increasing in the development of information literacy applications. The objective of this article is to define the development of information literacy; the changes in university education and libraries resulting from development of information literacy and to determine the position of library and librarians in the information literacy applications of Dokuz Eylul University.

  10. 44 CFR 152.4 - Roles and responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Roles and responsibilities... Roles and responsibilities. (a) Applicants must: (1) Complete the application and certify to the... grant, available if requested for an audit to ensure compliance with any requirement of the grant...

  11. 论社会角色理论在大中学校德育实践中的应用%The Application of Social Role Theory in the Practice of Ethical Education in Schools

    Institute of Scientific and Technical Information of China (English)

    方政

    2012-01-01

    社会学理论有着较高的应用价值,利用社会学的理论成果开展学校德育,将成为我们提高德育实效性的一种积极尝试。作为社会学基础理论之一的社会角色理论在大中学校德育实践中有重要应用价值,不仅有助于实现大中学校德育工作的目标,而且有助于实现大中学校德育衔接。社会角色理论应用于大中学校德育实践,有利于实现德育的生活化、提高德育的可操作性、增强德育的实效性。%Sociological theory has a higher value of practice.To make use of sociological theory results will be a proactive experiment of improving the effectiveness of ethical education.In sociology,sociological perspectives,theories,or paradigms are complex theoretical and methodological frameworks,used to analyze and explain objects of social study,and facilitate organizing sociological knowledge.Sociological theory is constantly evolving,therefore it can never be presumed to be complete.It can involve analysis at a macro-level,which focuses on social structures shaping the society or at a micro-level which is a close-up study on social interaction taking place in specific situations.As one of the basic theory of social roles,its purpose is to guide people to properly play a role in a society.This is the principle that people behave differently in social situations and take different roles,due to the expectations that society puts upon them.Social role theory is conducive to the improvement of the operability of ethical education and the enhancement of the effectiveness of ethical education.

  12. Practical applications of phosphors

    CERN Document Server

    Yen, William M; Yamamoto, Hajime

    2006-01-01

    Drawn from the second edition of the best-selling Phosphor Handbook, Practical Applications of Phosphors outlines methods for the production of various phosphors and discusses a broad spectrum of applications. Beginning with methods for synthesis and related technologies, the book sets the stage by classifying and then explaining practical phosphors according to usage. It describes the operating principle and structure of phosphor devices and the phosphor characteristics required for a given device, then covers the manufacturing processes and characteristics of phosphors. The book discusses research and development currently under way on phosphors with potential for practical usage and touches briefly on phosphors that have played a historical role, but are no longer of practical use. It provides a comprehensive treatment of applications including lamps and cathode-ray tubes, x-ray and ionizing radiation, and for vacuum fluorescent and field emission displays and covers inorganic and organic electroluminescen...

  13. Medical Applications

    OpenAIRE

    Biscari, C.; Falbo, L.

    2016-01-01

    The use of accelerators for medical applications has evolved from initial experimentation to turn-key devices commonly operating in hospitals. New applications are continuously being developed around the world, and the hadrontherapy facilities of the newest generation are placed at the frontier between industrial production and advanced R&D. An introduction to the different medical application accelerators is followed by a description of the hadrontherapy facilities, with special emphasis on ...

  14. LCA Applications

    DEFF Research Database (Denmark)

    Owsianiak, Mikołaj; Bjørn, Anders; Laurent, Alexis

    2018-01-01

    The chapter gives examples of applications of LCA by the central societal actors in government, industry and citizens, and discusses major motivations and challenges for the use of LCA to support science-based decision-making from their respective perspectives. We highlight applications of LCA...... environmental impacts of products and systems and support decisions around production and consumption and highlights factors that prevent its even more widespread application....

  15. Immunonutrition: the role of taurine.

    LENUS (Irish Health Repository)

    Redmond, H P

    2012-02-03

    Taurine is a sulfonated beta amino acid derived from methionine and cysteine metabolism. It is present in high concentrations in most tissues and in particular in proinflammatory cells such as polymorphonuclear phagocytes. Initial investigation into the multifaceted properties of this non-toxic physiologic amino acid revealed a link between retinal dysfunction and dietary deficiency. Since then a role for this amino acid has been found in membrane stabilization, bile salt formation, antioxidation, calcium homeostasis, growth modulation, and osmoregulation. Our own group has demonstrated a key role for taurine in modulation of apoptosis in a variety of cell types. This review summarizes our current knowledge of taurine in nutrition, host proinflammatory cell homeostasis, therapeutic applications, and its potential immunoregulatory properties. It is our belief that taurine, similar to arginine and glutamine, is now more than worthy of critical clinical analysis.

  16. 基于多智能体协同的角色互换策略的研究应用%Research Application Based on Strategy of Multi-Agent Cooperative Role Exchange

    Institute of Scientific and Technical Information of China (English)

    章成飞; 程泽凯; 秦锋

    2013-01-01

    Multi-Agent cooperative technology is an important branch in the field of Artificial Intelligence ( AI) . Robot football race pro-vides a test platform for the study of Multi-Agent cooperative technology. The football player named Agent in the robot simulation foot-ball race has both number attribute and role attribute. It makes Agent in the robot simulation football race as the research subject. Model for Agent with online coach mechanism and put forward the tactics to identify the counterparts as well as the strategy of football players'dynamic role exchange. In the underlying 2D of Agent,programming comes into effect. When one robot simulation football team tests with the other one,the winning probability is going to be raised by a big margin,which demonstrates the efficiency of this algorithm. And the algorithm can also improve attack ability of the football team.%多智能体协同技术是人工智能领域的一个重要分支。机器人足球比赛为多智能体协同技术的研究提供了一个测试平台,仿真机器人足球比赛球员Agent具有号码属性与角色属性。文中以仿真机器人足球比赛中的球员Agent为研究对象,利用在线教练机制对球员Agent进行建模,提出了对手角色识别策略以及基于多智能体协同的球员Agent动态角色互换策略。在Agent2D底层中编程实现,与某球队进行测试,胜率大大增加,结果表明了该算法的有效性,该算法可提高球队的进攻能力。

  17. Multimedia database retrieval technology and applications

    CERN Document Server

    Muneesawang, Paisarn; Guan, Ling

    2014-01-01

    This book explores multimedia applications that emerged from computer vision and machine learning technologies. These state-of-the-art applications include MPEG-7, interactive multimedia retrieval, multimodal fusion, annotation, and database re-ranking. The application-oriented approach maximizes reader understanding of this complex field. Established researchers explain the latest developments in multimedia database technology and offer a glimpse of future technologies. The authors emphasize the crucial role of innovation, inspiring users to develop new applications in multimedia technologies

  18. Enterprise Application Integration Using Java Technologies

    Directory of Open Access Journals (Sweden)

    Alexandru BARBULESCU

    2006-01-01

    Full Text Available The current article points out some of the tasks and challenges companies must face in order to integrate their computerized systems and applications and then to place them on the Web. Also, the article shows how the Java 2 Enterprise Edition Platform and architecture helps the Web integration of applications. By offering standardized integration contracts, J2EE Platform allows application servers to play a key role in the process of Web integration of the applications.

  19. Mobility chains analysis of technologies for passenger cars and light duty vehicles fueled with biofuels : application of the Greet model to project the role of biomass in America's energy future (RBAEF) project.

    Energy Technology Data Exchange (ETDEWEB)

    Wu, M.; Wu, Y.; Wang, M; Energy Systems

    2008-01-31

    The Role of Biomass in America's Energy Future (RBAEF) is a multi-institution, multiple-sponsor research project. The primary focus of the project is to analyze and assess the potential of transportation fuels derived from cellulosic biomass in the years 2015 to 2030. For this project, researchers at Dartmouth College and Princeton University designed and simulated an advanced fermentation process to produce fuel ethanol/protein, a thermochemical process to produce Fischer-Tropsch diesel (FTD) and dimethyl ether (DME), and a combined heat and power plant to co-produce steam and electricity using the ASPEN Plus{trademark} model. With support from the U.S. Department of Energy (DOE), Argonne National Laboratory (ANL) conducted, for the RBAEF project, a mobility chains or well-to-wheels (WTW) analysis using the Greenhouse gases, Regulated Emissions, and Energy use in Transportation (GREET) model developed at ANL. The mobility chains analysis was intended to estimate the energy consumption and emissions associated with the use of different production biofuels in light-duty vehicle technologies.

  20. Role of substrate and annealing temperature on the structure of ZnO and Al{sub x}Zn{sub 1−x}O thin films for solar cell applications

    Energy Technology Data Exchange (ETDEWEB)

    Nambala, Fred Joe [Department of Physics, University of Pretoria, Private bag X20, Hatfield 0028 (South Africa); Department of Physics, University of Zambia, PO Box 32379, Great East Road Campus, Lusaka (Zambia); Nel, Jacqueline M.; Machatine, Augusto G.J. [Department of Physics, University of Pretoria, Private bag X20, Hatfield 0028 (South Africa); Mwakikunga, Bonex W. [DST/CSIR National Centre for Nano-Structured Materials, PO Box 395, Pretoria (South Africa); Njoroge, Eric G. [Department of Physics, University of Pretoria, Private bag X20, Hatfield 0028 (South Africa); Maabong, Kelebogile [Department of Physics, University of Pretoria, Private bag X20, Hatfield 0028 (South Africa); Physics Department, University of Botswana, Private Bag 0022, Gaborone (Botswana); Das, Arran G.M. [Monash University, Private Bag X60, Roodepoort 1725 (South Africa); Diale, Mmantsae, E-mail: mmantsae.diale@up.ac.za [Department of Physics, University of Pretoria, Private bag X20, Hatfield 0028 (South Africa)

    2016-01-01

    This paper reports on the deposition of pure and 5 at% Al doped ZnO (AZO) prepared by sol–gel and applied to the substrates by spin-coating, and the role of annealing temperature on the crystallinity of these layers. It is found that both ZnO and AZO are largely amorphous when coated on glass compared to n-Si(111), as substrates. On both substrates, X-ray diffraction (XRD) shows that the crystallinity improves as annealing temperature is raised from 200 to 600 °C with better crystallinity on Si substrates. The thickness of the films on substrates was determined as 120 nm by Rutherford backscattering spectroscopy (RBS). Specular ultra-violet visible (UV–vis) gives the direct transition optical band gaps (E{sub g}) for AZO as-deposited films are 2.60 and 3.35 eV while that of 600 °C annealed films are 3.00 and 3.60 eV. The E{sub g} calculated from diffuse reflectance spectroscopy (DRS) UV–vis are more diverse in ZnO- and AZO-Si than the ZnO- and AZO-glass samples, although in both sets the E{sub g} tend to converge after annealing 600 °C. The Raman spectra of samples show multiphonon processes of higher order from the AZO and substrates. It is found that residual stresses are related to E{sub 2} Raman mode.

  1. The role of a decision-support smartphone application in enhancing community health volunteers' effectiveness to improve maternal and newborn outcomes in Nairobi, Kenya: quasi-experimental research protocol.

    Science.gov (United States)

    Bakibinga, Pauline; Kamande, Eva; Omuya, Milka; Ziraba, Abdhalah K; Kyobutungi, Catherine

    2017-07-20

    Improving maternal and newborn survival remains major aspirations for many countries in the Global South. Slum settlements, a result of rapid urbanisation in many developing countries including Kenya, exhibit high levels of maternal and neonatal mortality. There are limited referral mechanisms for sick neonates and their mothers from the community to healthcare facilities with ability to provide adequate care. In this study, we specifically plan to develop and assess the added value of having community health volunteers (CHVs) use smartphones to identify and track mothers and children in a bid to reduce pregnancy-related complications and newborn deaths in the urban slums of Kamukunji subcounty in Nairobi, Kenya. This is a quasi-experimental study. We are implementing an innovative, mHealth application known as mobile Partnership for Maternal, Newborn and Child Health (mPAMANECH) which uses dynamic mobile phone and web-portal solutions to enable CHVs make timely decisions on the best course of action in their management of mothers and newborns at community level. The application is based on existing guidelines and protocols in use by CHVs. Currently, CHVs conduct weekly home visits and make decisions from memory or using unwieldy manual tools, and thus prone to making errors. mPAMANECH has an in-built algorithm that makes it easier, faster and more likely for CHVs to make the right management decision. We are working with a network of selected CHVs and maternity centres to pilot test the tool. To measure the impact of the intervention, baseline and end-line surveys will be conducted. Data will be obtained through qualitative and quantitative methods. Ethical approval for the study was obtained from the African Medical Research Foundation. Key messages from the results will be packaged and disseminated through meetings, conference presentations, reports, fact sheets and academic publications to facilitate uptake by policy-makers. © Article author(s) (or their

  2. Industrial applications of computer tomography

    International Nuclear Information System (INIS)

    Sheng Kanglong; Qiang Yujun; Yang Fujia

    1992-01-01

    Industrial computer tomography (CT) and its application is a rapidly developing field of high technology. CT systems have been playing important roles in nondestructive testing (NDT) of products and equipment for a number of industries. Recently, the technique has advanced into the area of industrial process control, bringing even greater benefit to mankind. The basic principles and typical structure of an industrial CT system Descriptions are given of some successful CT systems for either NDT application or process control purposes

  3. PSA applications

    Energy Technology Data Exchange (ETDEWEB)

    Dubreuil Chambardel, A

    1997-12-31

    The IAEA now defines three types of PSA applications: Validation of design and of operation procedures; optimization of plant operation; and regulatory applications. The applications of PSA are manifold: only a few are dealt with here (precursor analysis is dealt with in session 3, topic 4). For each of them, we will do the utmost to demonstrate the main difficulties encountered, EDF`s viewpoint on the matter, and the points remaining to be solved. In what follows, unless explicitly stated otherwise, we have made every effort to represent the different applications as they are practiced by all concerned in the international community, and to describe the inherent difficulties the international community has encountered with these applications with all objectivity. It goes without saying that the comments below are simply those of the ESF department, and are submitted here for discussion by the experts. 13 refs.

  4. PSA applications

    International Nuclear Information System (INIS)

    Dubreuil Chambardel, A.

    1996-01-01

    The IAEA now defines three types of PSA applications: Validation of design and of operation procedures; optimization of plant operation; and regulatory applications. The applications of PSA are manifold: only a few are dealt with here (precursor analysis is dealt with in session 3, topic 4). For each of them, we will do the utmost to demonstrate the main difficulties encountered, EDF's viewpoint on the matter, and the points remaining to be solved. In what follows, unless explicitly stated otherwise, we have made every effort to represent the different applications as they are practiced by all concerned in the international community, and to describe the inherent difficulties the international community has encountered with these applications with all objectivity. It goes without saying that the comments below are simply those of the ESF department, and are submitted here for discussion by the experts. 13 refs

  5. Uranium - what role

    International Nuclear Information System (INIS)

    Grey, T.; Gaul, J.; Crooks, P.; Robotham, R.

    1980-01-01

    Opposing viewpoints on the future role of uranium are presented. Topics covered include the Australian Government's uranium policy, the status of nuclear power around the world, Australia's role as a uranium exporter and problems facing the nuclear industry

  6. Women And Leadership Roles

    OpenAIRE

    Parikh Indira J

    2003-01-01

    Women and Leadership Roles is culled from workshops conducted by Prof. Indira Parikh at the IIMA. From 1980 till date programmes exploring issues facing Women in Management are offered at the Institute. Issues surrounding leadership, work roles and authority are debated. The objectives are to explore the influence of the transformation of organisations on womens roles in the corporate world; to explore leadership roles and also individual life-spaces; to discover wholesome ways to actualise d...

  7. Dual Career Mothers' Role Conflict, Parental Roles, and Gender Roles.

    Science.gov (United States)

    Kinsella-Shaw, Mary; And Others

    The increasing numbers of married women working make the study of dual career mothers an important topic for the psychology of women. Such research is vital to helping women integrate careers with family life. A study was conducted to examine the extent to which gender role, number of hours worked per week, and number and age of children relate to…

  8. Nursing's role in Y2K planning.

    Science.gov (United States)

    Simpson, R L

    1999-04-01

    Why haven't more nurses fulfilled their role in Y2K planning? Nurses need to apply their skills and expertise to solving often overlooked problems such as point-of-service applications, transactions with business partners, and contingency planning.

  9. The Role of Statistics in Kosovo Enterprises

    Science.gov (United States)

    Gjonbalaj, Muje; Dema, Marjan; Miftari, Iliriana

    2009-01-01

    Considering science as the main contributor to contemporary developments has encouraged us to raise a scientific discussion regarding the role of statistics in business decision-making and economic development. Statistics, as an applicative science, is growing and being widely applied in different fields and professions. Statistical thinking is…

  10. Medical Applications

    CERN Document Server

    Biscari, C.

    2014-12-19

    The use of accelerators for medical applications has evolved from initial experimentation to turn-key devices commonly operating in hospitals. New applications are continuously being developed around the world, and the hadrontherapy facilities of the newest generation are placed at the frontier between industrial production and advanced R&D. An introduction to the different medical application accelerators is followed by a description of the hadrontherapy facilities, with special emphasis on CNAO, and the report closes with a brief outlook on the future of this field.

  11. Medical Applications

    International Nuclear Information System (INIS)

    Biscari, C; Falbo, L

    2014-01-01

    The use of accelerators for medical applications has evolved from initial experimentation to turn-key devices commonly operating in hospitals. New applications are continuously being developed around the world, and the hadrontherapy facilities of the newest generation are placed at the frontier between industrial production and advanced R&D. An introduction to the different medical application accelerators is followed by a description of the hadrontherapy facilities, with special emphasis on CNAO, and the report closes with a brief outlook on the future of this field

  12. Radioisotopes for medical applications

    International Nuclear Information System (INIS)

    Carr, S.

    1998-01-01

    For more than 3 decades, the Australian Nuclear Science and Technology Organisation has been the country's main supplier of radioisotopes for medical applications. The use of radioisotopes in medicine has revolutionised the diagnosis, management and treatment of many serious diseases such as cancer, heart disease and stroke. It is also beginning to play a key role in neurological disorders such as Parkinson and Alzheimers disease and epilepsy. More recently there has been considerable growth in the application of nuclear medicine to treat sport-related injuries - especially wrist, ankle and knees where more common techniques do not always enable accurate diagnosis. Australia is a recognised leader in nuclear medicine. This can be partially attributed to the close relationship between ANSTO and the medical community in providing opportunities to develop and evaluate new agents to support more effective patient care. A list of commercial isotopes produced in the reactor or the cyclotron and used in medical applications is given. Nuclear medicine plays an important role in the clinical environment and the timely supply of radioisotopes is a key element. ANSTO will continue to be the premier supplier of currently available and developing isotopes to support the health and well being of the Australian community

  13. Radioisotopes for medical applications

    Energy Technology Data Exchange (ETDEWEB)

    Carr, S. [Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW (Australia). Radiopharmaceuticals Division

    1998-03-01

    For more than 3 decades, the Australian Nuclear Science and Technology Organisation has been the country`s main supplier of radioisotopes for medical applications. The use of radioisotopes in medicine has revolutionised the diagnosis, management and treatment of many serious diseases such as cancer, heart disease and stroke. It is also beginning to play a key role in neurological disorders such as Parkinson and Alzheimers disease and epilepsy. More recently there has been considerable growth in the application of nuclear medicine to treat sport-related injuries - especially wrist, ankle and knees where more common techniques do not always enable accurate diagnosis. Australia is a recognised leader in nuclear medicine. This can be partially attributed to the close relationship between ANSTO and the medical community in providing opportunities to develop and evaluate new agents to support more effective patient care. A list of commercial isotopes produced in the reactor or the cyclotron and used in medical applications is given. Nuclear medicine plays an important role in the clinical environment and the timely supply of radioisotopes is a key element. ANSTO will continue to be the premier supplier of currently available and developing isotopes to support the health and well being of the Australian community 2 tabs., 1 fig.

  14. Microwave mixer technology and applications

    CERN Document Server

    Henderson, Bert

    2013-01-01

    Although microwave mixers play a critical role in wireless communication and other microwave applications employing frequency conversion circuits, engineers find that most books on this subject emphasize theoretical aspects, rather than practical applications. That's about to change with the forthcoming release of Microwave Mixer Technology and Applications. Based on a review of over one thousand patents on mixers and frequency conversion, authors Bert Henderson and Edmar Camargo have written a comprehensive book for mixer designers who want solid ideas for solving their own design challenges.

  15. Superconductivity - applications

    International Nuclear Information System (INIS)

    The paper deals with the following subjects: 1) Electronics and high-frequency technology, 2) Superconductors for energy technology, 3) Superconducting magnets and their applications, 4) Electric machinery, 5) Superconducting cables. (WBU) [de

  16. Photovoltaic applications

    International Nuclear Information System (INIS)

    Sidrach, M.

    1992-01-01

    The most common terrestrial applications of photovoltaic plants are reviewed. Classification of applications can be done considering end-use sectors and load profiles (consumption demand). For those systems with direct coupling the working point is determined by the intersection of the load line with the I-V curve Design guidelines are provided for photovoltaic systems. This lecture focusses on the distribution system and safeguards

  17. Laser Beam Scintillation with Applications

    CERN Document Server

    Andrews, Larry C; Young, Cynthia

    2001-01-01

    Renewed interest in laser communication systems has sparked development of useful new analytic models. This book discusses optical scintillation and its impact on system performance in free-space optical communication and laser radar applications, with a detailed look at propagation phenomena and the role of scintillation on system behavior. Intended for practicing engineers, scientists, and students.

  18. Multimedia applications in differential services

    International Nuclear Information System (INIS)

    Mahfooz, S.; Merabti, M.; Pereira, R.

    2003-01-01

    In this paper we present a mechanism to provide Quality of Service (QoS) guarantees to different multimedia applications that share link bandwidth in IP-based differential services domain. In this mechanism weights are associated with each and to individual users according to their priorities. In order to evaluate the performance of our scheme we conducted simulations. The test data used portray different multimedia applications i.e. MPEG-2, IP telephony. The simulation results obtained show the effectiveness of our scheme for multimedia applications by allocating link share to each multimedia application and minimising end-to-end transmission delay 9Y bringing them in line with the recommended standard acceptable transmission delay for multimedia applications. This paper also presents extension to our proposed Relative Bandwidth Sharing (RES) scheme for differential services. We have identified and highlighted the role of border routers and core routers in differential services domain. Exploring features of Internet Protocol IPv6 in our architecture. (author)

  19. Heat pipe applications workshop report

    International Nuclear Information System (INIS)

    Ranken, W.A.

    1978-04-01

    The proceedings of the Heat Pipe Applications Workshop, held at the Los Alamos Scientific Laboratory October 20-21, 1977, are reported. This workshop, which brought together representatives of the Department of Energy and of a dozen industrial organizations actively engaged in the development and marketing of heat pipe equipment, was convened for the purpose of defining ways of accelerating the development and application of heat pipe technology. Recommendations from the three study groups formed by the participants are presented. These deal with such subjects as: (1) the problem encountered in obtaining support for the development of broadly applicable technologies, (2) the need for applications studies, (3) the establishment of a heat pipe technology center of excellence, (4) the role the Department of Energy might take with regard to heat pipe development and application, and (5) coordination of heat pipe industry efforts to raise the general level of understanding and acceptance of heat pipe solutions to heat control and transfer problems

  20. Role of Negative Pressure Wound Therapy in Healing of Diabetic ...

    African Journals Online (AJOL)

    Journal of Surgical Technique and Case Report | Jan-Jun 2011 | Vol-3 | Issue-1. 10. Role of Negative ... case of any difficulty faced in the application of VAC dressings. BLEEDING ISSUE ... show exposed bone, tendon, joint capsule or fascia.

  1. The role of cyclosporine A on the periodontal tissues

    Directory of Open Access Journals (Sweden)

    Mallappa Jayasheela

    2013-01-01

    Conclusion: CsA targets the periodontal tissues (gingiva, alveolar bone and cementum in different pattern. Its role in cementogenesis can be utilized for periodontal regeneration, if its local application is testified and verified in the future animal studies.

  2. Ultracapacitors for automotive applications

    Science.gov (United States)

    Ashtiani, Cyrus; Wright, Randy; Hunt, Gary

    In response to a growing consensus in the auto industry that ultracapacitors can potentially play a key role in the modern vehicle power distribution network, a task force was created at the United States Advanced Battery Consortium (USABC) to tackle issues facing the fledging industry. The task force embarked on first developing and establishing standards for performance and abuse tolerance of ultracapacitors in collaboration with the U.S. Department of Energy and National Labs. Subsequently, potential applications in the automotive industry were identified and a consensus requirement specification was drawn as a development guide for the industry.

  3. Ultracapacitors for automotive applications

    Energy Technology Data Exchange (ETDEWEB)

    Ashtiani, Cyrus [DaimlerChrysler Corp., CIMS 526-00-00, 1870 Technology Dr., Troy, MI 48083 (United States); Wright, Randy; Hunt, Gary [Idaho National Laboratory, P.O. Box 1625, Idaho Falls, ID 834415-3830 (United States)

    2006-03-21

    In response to a growing consensus in the auto industry that ultracapacitors can potentially play a key role in the modern vehicle power distribution network, a task force was created at the United States Advanced Battery Consortium (USABC) to tackle issues facing the fledging industry. The task force embarked on first developing and establishing standards for performance and abuse tolerance of ultracapacitors in collaboration with the U.S. Department of Energy and National Labs. Subsequently, potential applications in the automotive industry were identified and a consensus requirement specification was drawn as a development guide for the industry. (author)

  4. Diverse applications of radioimmunoassay

    International Nuclear Information System (INIS)

    Yalow, R.S.

    1981-01-01

    The author discussed the issues concerning insulins of the different species (pig, dog and sperm whale) and the applications of species specific antisera in experimental and clinical settings. The possible role of a new form of ACTH as a hormonal marker was also discussed. Three species of insulin (pig, dog, and sperm whale) were separated by human antisera. Immune reaction was utilized to distinguish between endogenous human insulin and exogenously administered animal insulin. The longer acting insulins was found to be more immunogenic than regular crystalline insulins. Insulin concentrations in acid/ethanol extracts of the whole rat brain was about 25 times higher than plasma insulin. Plasma concentration of ACTH could be applicable to effect the distinction between tumor primary in or metastatic to the lung. (Nakanishi, T.)

  5. Biomedical applications of nanotechnology.

    Science.gov (United States)

    Ramos, Ana P; Cruz, Marcos A E; Tovani, Camila B; Ciancaglini, Pietro

    2017-04-01

    The ability to investigate substances at the molecular level has boosted the search for materials with outstanding properties for use in medicine. The application of these novel materials has generated the new research field of nanobiotechnology, which plays a central role in disease diagnosis, drug design and delivery, and implants. In this review, we provide an overview of the use of metallic and metal oxide nanoparticles, carbon-nanotubes, liposomes, and nanopatterned flat surfaces for specific biomedical applications. The chemical and physical properties of the surface of these materials allow their use in diagnosis, biosensing and bioimaging devices, drug delivery systems, and bone substitute implants. The toxicology of these particles is also discussed in the light of a new field referred to as nanotoxicology that studies the surface effects emerging from nanostructured materials.

  6. Applications of isotopes

    International Nuclear Information System (INIS)

    Kirby-Smith, J.S.

    1976-01-01

    Current and potential applications of stable isotopes as tracers in a number of biomedical and environmental areas are discussed. It is pointed out that a wide variety of problems exist in these fields whose solutions in principle are amenable to the isotopic approach. The number and diversity of these problems as well as the unique role stable isotopes can play in their solution illustrate the importance of achieving and maintaining a broad inventory of isotopic species. Experience has demonstrated unequivocally an additional overriding requirement for widespread exploration of stable isotopes by the scientific and technical community, i.e., the need for low cost availability of the materials in quantity. Some representative applications of 12 C, 13 C, 14 N, 15 N, 16 O, 17 O, and 18 O are discussed

  7. 49 CFR 256.11 - Applications.

    Science.gov (United States)

    2010-10-01

    ..., implementation, or operation of each project, along with a discussion of the role of each organization; (2) A...); (20) An opinion of the applicant's legal counsel advising that— (i) Counsel is familiar with— (A) The... organization's role; (4) A full discussion of the desirability and feasibility of the project and a summary of...

  8. Applications Using AIRS Data

    Science.gov (United States)

    Ray, S. E.; Pagano, T. S.; Fetzer, E. J.; Lambrigtsen, B.; Olsen, E. T.; Teixeira, J.; Licata, S. J.; Hall, J. R.; Thompson, C. K.

    2015-12-01

    The Atmospheric Infrared Sounder (AIRS) on NASA's Aqua spacecraft has been returning daily global observations of Earth's atmospheric constituents and properties since 2002. With a 12-year data record and daily, global observations in near real-time, AIRS data can play a role in applications that fall under many of the NASA Applied Sciences focus areas. For vector-borne disease, research is underway using AIRS near surface retrievals to assess outbreak risk, mosquito incubation periods and epidemic potential for dengue fever, malaria, and West Nile virus. For drought applications, AIRS temperature and humidity data are being used in the development of new drought indicators and improvement in the understanding of drought development. For volcanic hazards, new algorithms using AIRS data are in development to improve the reporting of sulfur dioxide concentration, the burden and height of volcanic ash and dust, all of which pose a safety threat to aircraft. In addition, anomaly maps of many of AIRS standard products are being produced to help highlight "hot spots" and illustrate trends. To distribute it's applications imagery, AIRS is leveraging existing NASA data frameworks and organizations to facilitate archiving, distribution and participation in the BEDI. This poster will communicate the status of the applications effort for the AIRS Project and provide examples of new maps designed to best communicate the AIRS data.

  9. Knowledge Management in Role Based Agents

    Science.gov (United States)

    Kır, Hüseyin; Ekinci, Erdem Eser; Dikenelli, Oguz

    In multi-agent system literature, the role concept is getting increasingly researched to provide an abstraction to scope beliefs, norms, goals of agents and to shape relationships of the agents in the organization. In this research, we propose a knowledgebase architecture to increase applicability of roles in MAS domain by drawing inspiration from the self concept in the role theory of sociology. The proposed knowledgebase architecture has granulated structure that is dynamically organized according to the agent's identification in a social environment. Thanks to this dynamic structure, agents are enabled to work on consistent knowledge in spite of inevitable conflicts between roles and the agent. The knowledgebase architecture is also implemented and incorporated into the SEAGENT multi-agent system development framework.

  10. PRIBIC Application

    International Nuclear Information System (INIS)

    Pascual Alonso, J.L.; Barcala Riveira, J.M.

    2002-01-01

    PRIBIC plant (Pollutants Reduction In small Biomass Combustion systems) at CEDER is a facility specifically designed to do biomass combustion tests. In these tests is necessary to know the values of different sensors in real time. With this information the PRIBIC plant is regulated to its optimum point of work and its possible to follow the operation criteria and get test objectives. Different electronic instruments record information about the plant operation. A software application was developed to let a centralised motorization of that information. The application communicates with the instrumentation, recovers data, lets operators see data in real time and saves the information in files. An important part of this document describes that application, and some considerations to generalise this kind of developments to other Experimental Plants, including cost estimations. Descriptions of plant, analysis of the problem, result evaluations, and conclusions can also be found in the document. (Author) 13 refs

  11. Forensic applications

    International Nuclear Information System (INIS)

    Yellin, E.

    1981-01-01

    Modern scientific technology now plays an increasingly important role in the process of law enforcement. Neutron activation, as developed for elemental analysis offers, in many cases, the suitable answer to forensic problems. The author discusses the use NAA has been put to in forensic science. (Auth.)

  12. Chemistry Teachers' Knowledge and Application of Models

    Science.gov (United States)

    Wang, Zuhao; Chi, Shaohui; Hu, Kaiyan; Chen, Wenting

    2014-01-01

    Teachers' knowledge and application of model play an important role in students' development of modeling ability and scientific literacy. In this study, we investigated Chinese chemistry teachers' knowledge and application of models. Data were collected through test questionnaire and analyzed quantitatively and qualitatively. The result indicated…

  13. Nuclear applications in life sciences

    International Nuclear Information System (INIS)

    Uenak, P.

    2009-01-01

    Radioactivity has revolutionized life sciences during the last century, and it is still an indispensable tool. Nuclear Medicine, Radiation Biology and Radiotherapy, Dosimetry and Medical Radiation Physics, Nutrition and Environmental Problems Relevant Health are significant application fields of Nuclear Sciences. Nuclear medicine today is a well established branch of medicine. Radionuclides and radiopharmaceuticals play a key role both in diagnostic investigations and therapy-Both cyclotron and reactor produced radionuclides find application, the former more in diagnostic studies and the latter in therapy. New therapy applications such as bor neutron therapy are increasing by time together with the technological improvements in imaging systems such as PET and SPECT. Radionuclides and radiopharmaceuticals play important role in both therapy and imaging. However cyclotron produced radionuclides have been using generally in imaging purposes while reactor produced radionuclides have also therapeutic applications. With the advent of emission tomography, new vistas for probing biochemistry in vivo have been opened. The radio chemist faces an ever-increasing challenge of designing new tracers for diagnostic and therapeutic applications. Rapid, efficient and automated methods of radionuclide and precursor production, labeling of biomolecules, and quality control need to be developed. The purpose of this article is a short interface from Nuclear Medicine, Radiation Biology and Radiotherapy, Dosimetry and Medical Radiation Physics Applications of Nuclear Sciences.

  14. Other applications

    International Nuclear Information System (INIS)

    Ligou, J.; Benoist, P.; Boffi, V.; Stenic, B.

    1981-01-01

    This chapter reports about the work done by four groups in Italy, France, Switzerland and Yugoslavia on the new applications of transport theory. Among them problems dealing with controlled thermonuclear reactions and/or fusion devices, nonlinear electric conductivity, atomic and crystal models were discussed

  15. A novel dual-ratiometric-response fluorescent probe for SO2/ClO- detection in cells and in vivo and its application in exploring the dichotomous role of SO2 under the ClO- induced oxidative stress.

    Science.gov (United States)

    Dou, Kun; Fu, Qiang; Chen, Guang; Yu, Fabiao; Liu, Yuxia; Cao, Ziping; Li, Guoliang; Zhao, Xianen; Xia, Lian; Chen, Lingxin; Wang, Hua; You, Jinmao

    2017-07-01

    Intracellular reactive sulfur species and reactive oxygen species play vital roles in immunologic mechanism. As an emerging signal transmitter, SO 2 can be generated as the anti-oxidant, while SO 2 is also a potential oxidative stress-inducer in organism. Aiming to elucidate in-depth the dichotomous role of SO 2 under oxidative stress, we designed a dual-response fluorescent probe that enabled the respective or successive detection of SO 2 and ClO - . The probe itself emits the red fluorescence (625 nm) which can largely switch to blue (410 nm) and green fluorescence (500 nm) respectively in response to SO 2 and ClO - , allowing the highly selective and accurate ratiometric quantification for both SO 2 and ClO - in cells. Moreover the ultrafast (SO 2 : <60 s; ClO - : within sec) and highly sensitive (detection limits: SO 2 : 3.5 nM; ClO - : 12.5 nM) detection were achieved. With the robust applicability, the developed probe was successfully used to quantify SO 2 and endogenous ClO - in respectively the HeLa cells and the RAW 264.7 cells, as well as to visualize the dynamic of SO 2 /ClO - in zebrafish. The fluorescent imaging studies and flow cytometry analysis confirmed the burst-and-depletion and meanwhile the oxidative-and-antioxidative effects of intracellular SO 2 under the NaClO induced oxidative stress. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Roles and responsibilities of the nursing scholar.

    Science.gov (United States)

    Conard, Patricia L; Pape, Tess Theresa

    2014-01-01

    Scholarship is an important facet of the nursing profession. There are many components, virtues, and roles and responsibilities of a nursing scholar practicing in today's ever-changing health care environment. Scholarship was redefined by Boyer to include scholarly activities in addition to research. Boyer's Model of Scholarship includes four interrelated and overlapping domains of discovery, integration, application, and teaching. Each domain is explained with examples for the pediatric nurse scholar, which includes roles in academia as well as in the practice setting. Pediatric nurses are key to scholarship in nursing because they work to improve the care of children.

  17. Docker Containers and Their Emerging Roles in Distributed Applications

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    **Sebastien Goasguen** built his first compute cluster in the late 90's when they were still called Beowulf clusters while working on his PhD; he has been working on making computing a utility since then. He has done research in grid computing and high performance computing and ...

  18. Role of Women Scientists and Teachers in promotion and application

    Indian Academy of Sciences (India)

    ranjeetha

    technology for the benefit of the society and in particular technological empowerment of women.” .... fisheries, soil management, low cost bio-fertilizer production, coir mat .... public campaigns on issues relating to cancer, hazards of smoking,.

  19. Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Laura Santangelo

    2017-01-01

    Full Text Available Exosomes are important in intercellular communication. They assure the horizontal transfer of specific functional contents (i.e., proteins, lipids, RNA molecules, and circulating DNA from donor to recipient cells. Notably, tumor-derived exosomes (TDEs appear to be an important vehicle of specific signals in cancer, impacting on tumor growth and metastasis. Recent researches point to the characterization of exosomes in Hepatocellular Carcinoma (HCC, the major adult liver malignancy. In this review, we summarize current findings on HCC exosomes, focusing on the identification of noncoding RNAs as exosome-enriched functional regulators and new potential biomarkers. The great potential of exosomes in future HCC diagnostic and therapeutic approaches is underlined.

  20. Potential role of glycosidase inhibitors in industrial biotechnological applications

    DEFF Research Database (Denmark)

    Sørensen, J.F.; Kragh, K.M.; Sibbesen, O.

    2004-01-01

    The nutrient content of food and animal feed may be improved through new knowledge about enzymatic changes in complex carbohydrates. Enzymatic hydrolysis of complex carbohydrates containing alpha or beta glycosidic bonds is very important in nutrition and in several technological processes......, produce glucose, fructose or dextrins, hydrolyse lactose, modify food pectins, or improve processes. However, many plant foods also contain endogenous inhibitors, which reduce the activity of glycosidases, in particular, proteins, peptides, complexing agents and phenolic compounds. The plant proteinaceous...

  1. Perspective role of stem cells application in neuropsychiatric research

    Czech Academy of Sciences Publication Activity Database

    Syková, Eva

    2003-01-01

    Roč. 13, č. 4 (2003), s. 148 ISSN 0924-977X. [Congress of the European College of Neuropsychopharmacology /16./. Prague, 20.09.2003-24.09.2003] R&D Projects: GA MŠk LN00A065; GA ČR GA304/03/1189 Institutional research plan: CEZ:AV0Z5039906; CEZ:MSM 111300004 Keywords : stem cells Subject RIV: FH - Neurology Impact factor: 2.842, year: 2003

  2. Future Roles of Structural Sensing for Aerospace Applications

    National Research Council Canada - National Science Library

    Derriso, Mark M; Chang, Fu-Kuo

    2006-01-01

    To reduce cost, increase availability, and maintain safety of current and future air vehicle systems, emphasis has been placed on the development of Integrated Systems Health Management (ISHM) techniques...

  3. Future Roles of Film Sound Design in VR-applications

    DEFF Research Database (Denmark)

    Nordahl, Rolf

    2005-01-01

    Virtual Environments offers new affordances for multimodal experiences. However, most research has been done on the visual modality and technologies supporting this sense In this paper new approaches to sound design for VE are proposed. Utilizing principles of film sound can prove beneficial in c...

  4. Role of metabolic stress for enhancing muscle adaptations: Practical applications

    OpenAIRE

    de Freitas, Marcelo Conrado; Gerosa-Neto, Jose; Zanchi, Nelo Eidy; Lira, Fabio Santos; Rossi, Fabr?cio Eduardo

    2017-01-01

    Metabolic stress is a physiological process that occurs during exercise in response to low energy that leads to metabolite accumulation [lactate, phosphate inorganic (Pi) and ions of hydrogen (H+)] in muscle cells. Traditional exercise protocol (i.e., Resistance training) has an important impact on the increase of metabolite accumulation, which influences hormonal release, hypoxia, reactive oxygen species (ROS) production and cell swelling. Changes in acute exercise routines, such as intensit...

  5. The future role of research reactors

    International Nuclear Information System (INIS)

    Glaeser, W.

    2001-01-01

    The decline of neutron source capacity in the next decades urges for the planning and construction of new neutron sources for basic and applied research with neutrons. Modern safety precautions of research reactors make them competitive with other ways of neutron production using non-chain reactions for many applications. Research reactors consequently optimized offer a very broad range of possible applications in basic and applied research. Research reactors at universities also in the future have to play an important role in education and training in basic and applied nuclear science. (orig.)

  6. Industrial applications of radiation technology

    International Nuclear Information System (INIS)

    Sarma, K.S.S.

    2012-01-01

    During the past one decade, Radiation Technology applications utilizing gamma radiation and high energy electrons have made a big way into the Indian industry bringing quality and value-added products in a more environment-friendly way. While radiation sterilization of health care products, hygienization of food materials, modification of polymer materials etc. are established as successful processes world wide including India, new applications are emerging especially in the field of environmental remediation. Two types of installations viz. gamma irradiators and high energy electron accelerators are in use right now to carry out such applications. The aim of the talk is to put forward before the audience about the potential applications developed in India and abroad, role of Department of Atomic Energy and current status of radiation processing for industrial utilization

  7. Clarifying the role of the IAEA

    International Nuclear Information System (INIS)

    Smith, R.

    1983-01-01

    The IAEA has many roles in promoting the role of nuclear energy for peaceful purposes. The most significant role that the IAEA undertakes is the development and application of safeguards to nuclear material, other material, equipment and facilities; this work consumes about 35% of the IAEA budget. The authority, procedures and limitations for the application of safeguards were described together with the relationship between the IAEA and the States where safeguards are in effect. Claims that the IAEA is not adequately fulfilling its safeguard role are usually based on misunderstandings of its role and authority. The IAEA's relationship to inspected States is not adversarial, regulatory, or guarding. It provides assurance to all States that peaceful nuclear activities are not diverted to a military program and in so doing enhances the reputation of States to whom safeguards are applied. Safeguards would be only one of many factors that would be involved in a States embarking on a military nuclear program. If proliferation of nuclear weapons occurs, this may be due in entirety or in part to these other factors. Many States could now undertake a military program but do not do so, because of their enlightened viewpoint that such activities are not in their own, or the world's best interests. However, any trend to further proliferation of nuclear weapons could be diminished by: -a lessening of political and economic tension between States, -restrictions on the supply of required technology, equipment, and material, and -an effective IAEA safeguard regime. There has been a regrettable trend to politicization in the direction and operation of the IAEA. It is hoped that this trend will be reversed and that IAEA will return to its earlier more technical role. There is a pressing need for the general public and governments to more fully understand the IAEA's role and its limitations

  8. Semantic Role Labeling

    CERN Document Server

    Palmer, Martha; Xue, Nianwen

    2011-01-01

    This book is aimed at providing an overview of several aspects of semantic role labeling. Chapter 1 begins with linguistic background on the definition of semantic roles and the controversies surrounding them. Chapter 2 describes how the theories have led to structured lexicons such as FrameNet, VerbNet and the PropBank Frame Files that in turn provide the basis for large scale semantic annotation of corpora. This data has facilitated the development of automatic semantic role labeling systems based on supervised machine learning techniques. Chapter 3 presents the general principles of applyin

  9. Semantics, Conceptual Role

    OpenAIRE

    Block, Ned

    1997-01-01

    According to Conceptual Role Semantics ("CRS"), the meaning of a representation is the role of that representation in the cognitive life of the agent, e.g. in perception, thought and decision-making. It is an extension of the well known "use" theory of meaning, according to which the meaning of a word is its use in communication and more generally, in social interaction. CRS supplements external use by including the role of a symbol inside a computer or a brain. The uses appealed to are not j...

  10. Application note :

    Energy Technology Data Exchange (ETDEWEB)

    Russo, Thomas V.

    2013-08-01

    The development of the XyceTM Parallel Electronic Simulator has focused entirely on the creation of a fast, scalable simulation tool, and has not included any schematic capture or data visualization tools. This application note will describe how to use the open source schematic capture tool gschem and its associated netlist creation tool gnetlist to create basic circuit designs for Xyce, and how to access advanced features of Xyce that are not directly supported by either gschem or gnetlist.

  11. Nursing Reclaims its Role.

    Science.gov (United States)

    Diers, Donna

    1982-01-01

    An attempt is made to explain the nurses' role: what the nurse is, what the nurse does, how the nurse is viewed by society, why nurses suffer burnout, nursing costs, and health care system reform. (CT)

  12. Role-Playing Mitosis.

    Science.gov (United States)

    Wyn, Mark A.; Stegink, Steven J.

    2000-01-01

    Introduces a role playing activity that actively engages students in the learning process of mitosis. Students play either chromosomes carrying information, or cells in the cell membrane. (Contains 11 references.) (Author/YDS)

  13. Roles within the Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Text Size Email Print Share Roles Within the Family Page Content Article Body Families are not democracies. ...

  14. The role of parliament

    International Nuclear Information System (INIS)

    Valesco, R.G.

    2007-01-01

    The author explained the nature and role of the spanish Parliament in nuclear affairs. She recalled that all members of the Parliament unanimously supported the development of a centralized radioactive waste storage facility. (A.L.B.)

  15. Managerial accounting applications in radiology.

    Science.gov (United States)

    Lexa, Frank James; Mehta, Tushar; Seidmann, Abraham

    2005-03-01

    We review the core issues in managerial accounting for radiologists. We introduce the topic and then explore its application to diagnostic imaging. We define key terms such as fixed cost, variable cost, marginal cost, and marginal revenue and discuss their role in understanding the operational and financial implications for a radiology facility by using a cost-volume-profit model. Our work places particular emphasis on the role of managerial accounting in understanding service costs, as well as how it assists executive decision making.

  16. Authorization Administration in a Distributed Multi-application Environment

    Institute of Scientific and Technical Information of China (English)

    DUAN Sujuan; HONG Fan; LI Xinhua

    2004-01-01

    To meet the authorization administration requirements in a distributed computer network environment, this paper extends the role-based access control model with multiple application dimensions and establishes a new access control model ED-RBAC(Extended Role Based Access Control Model) for the distributed environment. We propose an extendable hierarchical authorization assignment framework and design effective role-registering, role-applying and role-assigning protocol with symmetric and asymmetric cryptographic systems. The model can be used to simplify authorization administration in a distributed environment with multiple applications.

  17. Role of carnitine in disease

    Directory of Open Access Journals (Sweden)

    Flanagan Judith L

    2010-04-01

    Full Text Available Abstract Carnitine is a conditionally essential nutrient that plays a vital role in energy production and fatty acid metabolism. Vegetarians possess a greater bioavailability than meat eaters. Distinct deficiencies arise either from genetic mutation of carnitine transporters or in association with other disorders such as liver or kidney disease. Carnitine deficiency occurs in aberrations of carnitine regulation in disorders such as diabetes, sepsis, cardiomyopathy, malnutrition, cirrhosis, endocrine disorders and with aging. Nutritional supplementation of L-carnitine, the biologically active form of carnitine, is ameliorative for uremic patients, and can improve nerve conduction, neuropathic pain and immune function in diabetes patients while it is life-saving for patients suffering primary carnitine deficiency. Clinical application of carnitine holds much promise in a range of neural disorders such as Alzheimer's disease, hepatic encephalopathy and other painful neuropathies. Topical application in dry eye offers osmoprotection and modulates immune and inflammatory responses. Carnitine has been recognized as a nutritional supplement in cardiovascular disease and there is increasing evidence that carnitine supplementation may be beneficial in treating obesity, improving glucose intolerance and total energy expenditure.

  18. The role of precise time in IFF

    Science.gov (United States)

    Bridge, W. M.

    1982-01-01

    The application of precise time to the identification of friend or foe (IFF) problem is discussed. The simple concept of knowing when to expect each signal is exploited in a variety of ways to achieve an IFF system which is hard to detect, minimally exploitable and difficult to jam. Precise clocks are the backbone of the concept and the various candidates for this role are discussed. The compact rubidium-controlled oscillator is the only practical candidate.

  19. Risk assessment of forensic patients: nurses' role.

    Science.gov (United States)

    Encinares, Maxima; McMaster, Jeff James; McNamee, Jim

    2005-03-01

    One of the unique roles of forensic nurses is to conduct risk assessments. Establishing a therapeutic nurse-patient relationship helps forensic nurses perform accurate and useful risk assessments. Accurate risk assessments can facilitate formulation of individualized risk management plans, designed to meet patients' needs and ensure public safety. The importance of forensic nurses' knowledge and application of appropriate communication and proper documentation cannot be overemphasized.

  20. Vacuum science, technology, and applications

    CERN Document Server

    Naik, Pramod K

    2018-01-01

    Vacuum plays an important role in science and technology. The study of interaction of charged particles, neutrals and radiation with each other and with solid surfaces requires a vacuum environment for reliable investigations. Vacuum has contributed immensely to advancements made in nuclear science, space, metallurgy, electrical/electronic technology, chemical engineering, transportation, robotics and many other fields. This book is intended to assist students, scientists, technicians and engineers to understand the basics of vacuum science and technology for application in their projects. The fundamental theories, concepts, devices, applications, and key inventions are discussed.

  1. Photography applications

    Science.gov (United States)

    Cochran, Susan A.; Goodman, James A.; Purkis, Samuel J.; Phinn, Stuart R.

    2013-01-01

    Photographic imaging is the oldest form of remote sensing used in coral reef studies. This chapter briefly explores the history of photography from the 1850s to the present, and delves into its application for coral reef research. The investigation focuses on both photographs collected from low-altitude fixed-wing and rotary aircraft, and those collected from space by astronauts. Different types of classification and analysis techniques are discussed, and several case studies are presented as examples of the broad use of photographs as a tool in coral reef research.

  2. Perceived Role Achievement and Role Expectation of Local ...

    African Journals Online (AJOL)

    USER

    Keywords: Local governments, role expectations and role achievements, southeast .... Four point, five point and three point Likert- type scales were used to measure role ... (2009) reports that procurement of farm inputs for farmers is one of the.

  3. Teacher roles in Learning Games

    DEFF Research Database (Denmark)

    Magnussen, Rikke

    2007-01-01

    the roles as forensic experts who solve a series of murder cases. When teachers use this type of games, they have to adapt to new teaching situations and roles. This includes the fictional role in a game, but also the role as a supervisor for a group of students that play the role as professional experts. I...

  4. Gender roles revised?

    DEFF Research Database (Denmark)

    Gustafsson, Jessica

    2018-01-01

    The aim of this chapter is to deepen the understanding of how mobile phone usage is related to gender in general and the negotiation of gender roles in particular. It will focus on how women in Kenya appropriate mobile phones and how the appropriation is influenced by prevailing gender norms...... but also in turn is influencing gender relations. Mobile phone use is strongly intertwined with everyday life and thus this chapter will approach mobile phone use, as practices or a site where gender roles are potentially negotiated, challenged but also reinforced. Geographically the study that constituted...... the basis for this chapter is set in Kenya, where family relations and gender roles is presently undergoing changes. The data was gathered in Uasin Gishu County, Kenya, an area, which is predominantly rural, but also home to the city Eldoret and its surrounding peri-urban areas. The situation for women...

  5. Ice slurry applications

    Energy Technology Data Exchange (ETDEWEB)

    Kauffeld, M. [Karlsruhe University of Applied Sciences, Moltkestr. 30, 76133 Karlsruhe (Germany); Wang, M.J.; Goldstein, V. [Sunwell Technologies Inc., 180 Caster Avenue, Woodbridge, L4L 5Y (Canada); Kasza, K.E. [Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States)

    2010-12-15

    The role of secondary refrigerants is expected to grow as the focus on the reduction of greenhouse gas emissions increases. The effectiveness of secondary refrigerants can be improved when phase changing media are introduced in place of single-phase media. Operating at temperatures below the freezing point of water, ice slurry facilitates several efficiency improvements such as reductions in pumping energy consumption as well as lowering the required temperature difference in heat exchangers due to the beneficial thermo-physical properties of ice slurry. Research has shown that ice slurry can be engineered to have ideal ice particle characteristics so that it can be easily stored in tanks without agglomeration and then be extractable for pumping at very high ice fraction without plugging. In addition ice slurry can be used in many direct contact food and medical protective cooling applications. This paper provides an overview of the latest developments in ice slurry technology. (author)

  6. Applications of cerebral SPECT

    Energy Technology Data Exchange (ETDEWEB)

    McArthur, C., E-mail: claire.mcarthur@nhs.net [Department of Neuroradiology, Institute of Neurological Sciences, Glasgow (United Kingdom); Jampana, R.; Patterson, J.; Hadley, D. [Department of Neuroradiology, Institute of Neurological Sciences, Glasgow (United Kingdom)

    2011-07-15

    Single-photon emission computed tomography (SPECT) can provide three-dimensional functional images of the brain following the injection of one of a series of radiopharmaceuticals that crosses the blood-brain barrier and distributes according to cerebral perfusion, neurotransmitter, or cell density. Applications include differentiating between the dementias, evaluating cerebrovascular disease, preoperative localization of epileptogenic foci, diagnosing movement disorders, and evaluation of intracerebral tumours, while also proving a useful research tool. Unlike positronemission tomography (PET), SPECT imaging is widely available and can be performed in any department that has access to a rotating gamma camera. The purpose of this review is to demonstrate the utility of cerebral SPECT and increase awareness of its role in the investigation of neurological and psychiatric disorders.

  7. Detector applications

    International Nuclear Information System (INIS)

    Pehl, R.H.

    1977-10-01

    Semiconductor detectors are now applied to a very wide range of problems. The combination of relatively low cost, excellent energy resolution, and simultaneous broad energy-spectrum analysis is uniquely suited to many applications in both basic and applied physics. Alternative techniques, such as magnetic spectrometers for charged-particle spectroscopy, while offering better energy resolution, are bulky, expensive, and usually far more difficult to use. Furthermore, they do not directly provide the broad energy-spectrum measurements easily accomplished using semiconductor detectors. Scintillation detectors, which are approximately equivalent to semiconductor detectors in convenience and cost, exhibit 10 to 100 times worse energy resolution. However, their high efficiency and large potential size recommend their use in some measurements

  8. Women in Leading Role

    Science.gov (United States)

    Rácz, Anita

    2016-01-01

    The questions related to the role of women in the world of labour and to the rate of female and male employees are issues that have been discussed since long ago. Equality of women and the fight against the discrimination of women are hot topics not only for the "weaker sex" as there are abundant research and literature dealing with the…

  9. Coeducation and Sex Roles.

    Science.gov (United States)

    Harris, Mary B.

    1986-01-01

    A study of the sex role stereotypes held by 538 first-term Australian university students from single-sex and coeducational high schools is presented. Results suggest that coeducational schooling may have some advantages for fostering interactions with the opposite sex. (MSE)

  10. Dad's Role in Breastfeeding

    Science.gov (United States)

    ... Share Dad's Role in Breastfeeding Page Content Article Body Let’s say you and mom have talked about it and ... is the medical term for the way the body makes room for incoming food by ... that your baby poops every time she nurses. Step in to handle this ...

  11. Biological role of nickel

    Energy Technology Data Exchange (ETDEWEB)

    Thauer, R K; Diekert, G; Schoenheit, P

    1980-01-01

    Several enzymes and one cofactor have recently been shown to contain nickel. For example, urease of jack beans has been found to be a nickel protein and factor F/sub 430/ from methanogenic bacteria to be a nickel tetrapyrrole. The biological role of nickel in several organisms is discussed.

  12. CNS role evolution.

    Science.gov (United States)

    Payne, J L; Baumgartner, R G

    1996-01-01

    THE CNS ROLE has been actualized in a variety of ways. Flexibility-inherent in the role-and the revolution in health care consciousness tend to place the CNS at risk for criticism regarding value to the organization. At Vanderbilt University Medical Center, a CNS task force evaluated the current reality of CNS practice and recommended role changes to include the financial analysis of patient care. After incorporating a financial perspective into our present practice, we have embarked on an interesting journey of post-Master's degree study, that of the tertiary care nurse practitioner. This practice option could elevated the clinical and financial aspects of providing cost-effective health care to a more autonomous role form; however, the transition has been challenging. Since 1990, the American Nurses Association has recommended that nursing school curricula change to meet the needs of the health care environment and provide increased career flexibility through creating one advanced degree incorporating both CNS and NP functions. Swiftly moving past differences and toward similarities will bridge the gap for advanced practice nurses in the future.

  13. Role extension and role advancement - Is there a difference? A discussion paper

    International Nuclear Information System (INIS)

    Hardy, Maryann; Snaith, Beverly

    2006-01-01

    The terms 'extended' and 'advanced' practice are commonly used to describe clinical practitioner roles. However, these terms have not been clearly defined within the context of modern radiography practice despite their fundamental importance to establishing the 4 tier structure, implementing Agenda for Change and promoting a coherent clinical radiography career structure. This paper discusses the terms 'extension' and 'advancement' in relation to radiography practice and, using evidence from the debates of other health professions, attempts to offer some clarity to the terminology, presenting one interpretation of its possible application to the radiographer role in the United Kingdom

  14. Role extension and role advancement - Is there a difference? A discussion paper

    Energy Technology Data Exchange (ETDEWEB)

    Hardy, Maryann [Division of Radiography, School of Health Studies, University of Bradford, Trinity Road, Bradford, West Yorkshire BD5 0BB (United Kingdom)]. E-mail: m.l.hardy1@bradford.ac.uk; Snaith, Beverly [Mid Yorkshire Hospitals NHS Trust (United Kingdom)

    2006-11-15

    The terms 'extended' and 'advanced' practice are commonly used to describe clinical practitioner roles. However, these terms have not been clearly defined within the context of modern radiography practice despite their fundamental importance to establishing the 4 tier structure, implementing Agenda for Change and promoting a coherent clinical radiography career structure. This paper discusses the terms 'extension' and 'advancement' in relation to radiography practice and, using evidence from the debates of other health professions, attempts to offer some clarity to the terminology, presenting one interpretation of its possible application to the radiographer role in the United Kingdom.

  15. Clinical applications

    International Nuclear Information System (INIS)

    Anon.

    1982-01-01

    The Oak Ridge Calutron facility has been a critical factor in the development and subsequent production of a majority of currently useful medical radionuclides. The role of stable isotopes in the development of radiopharmaceuticals is described. Some examples are: stable isotope molybdenum-98 for producing radiopharmaceuticals incorporating technetium-99m; thallium-203 precursor for thallium-201 which is used as tracers in the detection of coronary-heart disease; zinc-68 precursor of gallium-67 which is used in the diagnosis of tumors and infections. The continued availability of the isotopic materials necessary for optimal health care can only be achieved by taking the following actions: (1) stocks of all the stable isotopes from which products for research and patient care are derived must be expanded and maintained; (2) all facilities, including the calutrons, capable of furnishing products to meet these needs should be identified and described; federal support for the research and development of alternative separation methods should continue; (3) an advisory committee should be created to set realistic goals, to evaluate resources, and coordinate overall efforts

  16. Connected vehicle applications : environment.

    Science.gov (United States)

    2016-01-01

    The U.S. Department of Transportation has developed a number of connected vehicle environmental applications, including the Applications for the Environment Real-Time Information Synthesis (AERIS) research program applications and road weather applic...

  17. Environmental applications for biosurfactants

    Energy Technology Data Exchange (ETDEWEB)

    Mulligan, Catherine N. [Department Building, Civil and Environmental Engineering, Concordia University, 1455 de Maisonneuve Boulevard W., Montreal, Quebec, H3G 1M8 (Canada)]. E-mail: mulligan@civil.concordia.ca

    2005-01-01

    Biosurfactants are surfactants that are produced extracellularly or as part of the cell membrane by bacteria, yeasts and fungi. Examples include Pseudomonas aeruginosa which produces rhamnolipids, Candida (formerly Torulopsis) bombicola, one of the few yeasts to produce biosurfactants, which produces high yields of sophorolipids from vegetable oils and sugars and Bacillus subtilis which produces a lipopeptide called surfactin. This review includes environmental applications of these biosurfactants for soil and water treatment. Biosurfactant applications in the environmental industries are promising due to their biodegradability, low toxicity and effectiveness in enhancing biodegradation and solubilization of low solubility compounds. However, more information is needed to be able to predict and model their behaviour. Full scale tests will be required. The role of biosurfactants in natural attenuation processes has not been determined. Very little information is available concerning the influence of soil components on the remediation process with biosurfactants. As most of the research until now has been performed with rhamnolipids, other biosurfactants need to be investigated as they may have more promising properties. - More information is needed to be able to predict and model the behaviour of biosurfactants.

  18. Environmental applications for biosurfactants

    International Nuclear Information System (INIS)

    Mulligan, Catherine N.

    2005-01-01

    Biosurfactants are surfactants that are produced extracellularly or as part of the cell membrane by bacteria, yeasts and fungi. Examples include Pseudomonas aeruginosa which produces rhamnolipids, Candida (formerly Torulopsis) bombicola, one of the few yeasts to produce biosurfactants, which produces high yields of sophorolipids from vegetable oils and sugars and Bacillus subtilis which produces a lipopeptide called surfactin. This review includes environmental applications of these biosurfactants for soil and water treatment. Biosurfactant applications in the environmental industries are promising due to their biodegradability, low toxicity and effectiveness in enhancing biodegradation and solubilization of low solubility compounds. However, more information is needed to be able to predict and model their behaviour. Full scale tests will be required. The role of biosurfactants in natural attenuation processes has not been determined. Very little information is available concerning the influence of soil components on the remediation process with biosurfactants. As most of the research until now has been performed with rhamnolipids, other biosurfactants need to be investigated as they may have more promising properties. - More information is needed to be able to predict and model the behaviour of biosurfactants

  19. Teleneurology applications

    Science.gov (United States)

    Wechsler, Lawrence R.; Tsao, Jack W.; Levine, Steven R.; Swain-Eng, Rebecca J.; Adams, Robert J.; Demaerschalk, Bart M.; Hess, David C.; Moro, Elena; Schwamm, Lee H.; Steffensen, Steve; Stern, Barney J.; Zuckerman, Steven J.; Bhattacharya, Pratik; Davis, Larry E.; Yurkiewicz, Ilana R.; Alphonso, Aimee L.

    2013-01-01

    Objective: To review current literature on neurology telemedicine and to discuss its application to patient care, neurology practice, military medicine, and current federal policy. Methods: Review of practice models and published literature on primary studies of the efficacy of neurology telemedicine. Results: Teleneurology is of greatest benefit to populations with restricted access to general and subspecialty neurologic care in rural areas, those with limited mobility, and those deployed by the military. Through the use of real-time audio-visual interaction, imaging, and store-and-forward systems, a greater proportion of neurologists are able to meet the demand for specialty care in underserved communities, decrease the response time for acute stroke assessment, and expand the collaboration between primary care physicians, neurologists, and other disciplines. The American Stroke Association has developed a defined policy on teleneurology, and the American Academy of Neurology and federal health care policy are beginning to follow suit. Conclusions: Teleneurology is an effective tool for the rapid evaluation of patients in remote locations requiring neurologic care. These underserved locations include geographically isolated rural areas as well as urban cores with insufficient available neurology specialists. With this technology, neurologists will be better able to meet the burgeoning demand for access to neurologic care in an era of declining availability. An increase in physician awareness and support at the federal and state level is necessary to facilitate expansion of telemedicine into further areas of neurology. PMID:23400317

  20. The roles of government

    International Nuclear Information System (INIS)

    Aigrain, P.

    1988-01-01

    The author chooses to address his talk to governments as a broad category, not differentiating the more centralized, socialized, federal, or for that matter the role of smaller governmental entities within countries, and the role they can have in impacting science. He chooses to try to say what governments should do, and with a few exceptions, what they should avoid doing, in order to support the development of physics, and for that matter other sciences within their countries. The major role is in education, where governments can prepare people for work in these disciplines, and also present the disciplines in an interesting manner so that the best minds can be attracted to these areas. The second major role is in the support of basic research in high technology areas. Some of this involves very large resource investments, but not all areas are equally expensive to support. There is a particular pitfall when governments become the consumer for basic research, for example in the case of national defense concerns, when the consumer can have a profound effect on the research effort in a country, not always for the betterment of science or society. Fiscal matters are equally important, not only in the support of the individual worker, support of the basic research, support of education, but also in the general attititude to supporting physics high tech work in the private sector within countries. Governmantal fiscal policies can have profound influences on the way private capital flows into such initiatives. Finally he touches on the need for those in basic research and high tech work to have contacts, all kinds of contacts, which foster the exchange of information and ideas, and the development of new approaches to old and new problems

  1. Recent advances in application of EB Technology

    Energy Technology Data Exchange (ETDEWEB)

    Mittendorfer, J [Mediscan GmbH, Kremsmuenster (Austria)

    2001-07-01

    In this paper recent advances in application of electron beam technology are presented. Important industrial and scientific achievements of the international community, together with research by Mediscan, Austria, an operator of state-of-the-art electron beam service center and innovator in the field of EB-Technology are reviewed. In addition, areas which may play an important role in the future are identified. Special focus is on the use of X-ray converters and the potential for industrial applications. (author)

  2. Biomedical and therapeutic applications of biosurfactants

    OpenAIRE

    Rodrigues, L. R.; Teixeira, J. A.

    2010-01-01

    During the last years, several applications of biosurfactants with medical purposes have been reported. Biosurfactants are considered relevant molecules for applications in combating many diseases and as therapeutic agents due to their antibacterial, antifungal and antiviral activities. Furthermore, their role as anti-adhesive agents against several pathogens illustrate their utility as suitable anti-adhesive coating agents for medical insertional materials leading to a reduction of a large n...

  3. Multiphysics simulation electromechanical system applications and optimization

    CERN Document Server

    Dede, Ercan M; Nomura, Tsuyoshi

    2014-01-01

    This book highlights a unique combination of numerical tools and strategies for handling the challenges of multiphysics simulation, with a specific focus on electromechanical systems as the target application. Features: introduces the concept of design via simulation, along with the role of multiphysics simulation in today's engineering environment; discusses the importance of structural optimization techniques in the design and development of electromechanical systems; provides an overview of the physics commonly involved with electromechanical systems for applications such as electronics, ma

  4. Recent advances in application of EB Technology

    International Nuclear Information System (INIS)

    Mittendorfer, J.

    2001-01-01

    In this paper recent advances in application of electron beam technology are presented. Important industrial and scientific achievements of the international community, together with research by Mediscan, Austria, an operator of state-of-the-art electron beam service center and innovator in the field of EB-Technology are reviewed. In addition, areas which may play an important role in the future are identified. Special focus is on the use of X-ray converters and the potential for industrial applications. (author)

  5. Nuclear radiation applications in hydrological investigations

    International Nuclear Information System (INIS)

    Rao, S.M.

    1978-01-01

    The applications of radiation sources for the determination of water and soil properties in hydrological investigations are many and varied. These include snow gauging, soil moisture and density determinations, measurement of suspended sediment concentrations in natural streams and nuclear well logging for groundwater exploitation. Besides the above, many radiation physics aspects play an important role in the development of radiotracer techniques, particularly in sediment transport studies. The article reviews the above applications with reference to their limitations and advantages. (author)

  6. Advanced Ceramic Materials for Future Aerospace Applications

    Science.gov (United States)

    Misra, Ajay

    2015-01-01

    With growing trend toward higher temperature capabilities, lightweight, and multifunctionality, significant advances in ceramic matrix composites (CMCs) will be required for future aerospace applications. The presentation will provide an overview of material requirements for future aerospace missions, and the role of ceramics and CMCs in meeting those requirements. Aerospace applications will include gas turbine engines, aircraft structure, hypersonic and access to space vehicles, space power and propulsion, and space communication.

  7. The motivational theory of role modeling : How role models influence role aspirants' goals

    NARCIS (Netherlands)

    Morgenroth, Thekla; Ryan, Michelle K.; Peters, Kim

    2015-01-01

    Role models are often suggested as a way of motivating individuals to set and achieve ambitious goals, especially for members of stigmatized groups in achievement settings. Yet, the literature on role models tends not to draw on the motivational literature to explain how role models may help role

  8. Strategic Roles of Manufacturing

    DEFF Research Database (Denmark)

    Yang, Cheng

    with the trend of globalisation, how do industrial companies develop their global manufacturing networks? These two questions are actually interlinked. On the one hand, facing increasing offshoring and outsourcing of production activities, industrial companies have to understand how to develop their global...... manufacturing networks. On the other hand, ongoing globalisation also brings tremendous impacts to post-industrial economies (e.g. Denmark). A dilemma therefore arises, i.e. whether it is still necessary to keep manufacturing in these post-industrial economies; if yes, what kinds of roles manufacturing should...

  9. [Historical roles of salt].

    Science.gov (United States)

    Ritz, E; Ritz, C

    2004-12-17

    Recently increasing evidence has been provided pointing to a close relation of salt consumption to hypertension as well as to target organ damage. It is interesting to note that the discussion concerning salt is unusually emotional. This may be explained, at least in part, by the fact that since ancient times salt had deep symbolic significance, as exemplified, mostly subconsciously, by many customs and expressions still in current use. In the past salt was essential to preserve food. The past importance of salt as a commodity can well be compared with that of oil today. These and further historical aspects of the role of salt are briefly dealt with in this article.

  10. The Role of Madrasas

    DEFF Research Database (Denmark)

    Vestenskov, David

    This book is the combined result of all three studies edited by the RDDC. The intention is to provide a more nuanced view on the role of madrasas in Afghanistan and Pakistan by addressing some of the core questions pertaining to these institutions: Why do Pakistani parents decide to send...... their children to madrasas instead of public schools? From which sources do the Pakistani madrasas generate their funding, and how dependent are they on this funding? What are recent developments and which groups run madrasas in Afghanistan? This book presents the findings from the extensive data...

  11. Role Models on Dope

    DEFF Research Database (Denmark)

    Christiansen, Ask Vest; Gleaves, John

    2014-01-01

    Compared to football-players cyclists are virtuous role models. Yes, Lance Armstrong, Michael Rasmussen and other riders have doped, and because of this they have received the predicate as the most immoral athletes in the sporting world. But if morality is not only a question of whether a person ...... has enhanced his or hers performances by the use of various drugs (and lied about it), but also is about human beings’ relations and interactions, then cycling isn’t as depraved as we like to tell each other. Football is much worse....

  12. Handbook of Mobile Systems Applications and Services

    CERN Document Server

    Kumar, Anup

    2012-01-01

    From fundamental concepts and theories to implementation protocols and cutting-edge applications, the Handbook of Mobile Systems Applications and Services supplies a complete examination of the evolution of mobile services technologies. It examines service-oriented architecture (SOA) and explains why SOA and Service Oriented Computing (SOC) will play key roles in the development of future mobile services. Investigating current service discovery frameworks, the book covers the basics of mobile services and applications developed in various contexts. The first section provides readers with the r

  13. Symposium on isotope production and applications

    International Nuclear Information System (INIS)

    1981-01-01

    This report contains the papers delivered at the symposium on isotope production and applications, held at Pelindaba, Pretoria, South Africa. The following topics were discussed: facilities for the production of radioisotopes at Pelindaba; the role of the chemist in the development and production of radioisotopic preparations; quality control of radioisotopic products; applications of radioisotopes in medicine; concepts and current status of nuclear imaging; industrial and research applications of radioisotopic tracers and radioisotopic radiation sources; radiation processing using intense radioisotopic radiation sources; a review of current and future radioisotope production activities at the Council for Scientific and Industrial Research

  14. MEMS for automotive and aerospace applications

    CERN Document Server

    Kraft, Michael

    2013-01-01

    MEMS for automotive and aerospace applications reviews the use of Micro-Electro-Mechanical-Systems (MEMS) in developing solutions to the unique challenges presented by the automotive and aerospace industries.Part one explores MEMS for a variety of automotive applications. The role of MEMS in passenger safety and comfort, sensors for automotive vehicle stability control applications and automotive tire pressure monitoring systems are considered, along with pressure and flow sensors for engine management, and RF MEMS for automotive radar sensors. Part two then goes on to explore MEMS for

  15. Role of computers in CANDU safety systems

    International Nuclear Information System (INIS)

    Hepburn, G.A.; Gilbert, R.S.; Ichiyen, N.M.

    1985-01-01

    Small digital computers are playing an expanding role in the safety systems of CANDU nuclear generating stations, both as active components in the trip logic, and as monitoring and testing systems. The paper describes three recent applications: (i) A programmable controller was retro-fitted to Bruce ''A'' Nuclear Generating Station to handle trip setpoint modification as a function of booster rod insertion. (ii) A centralized monitoring computer to monitor both shutdown systems and the Emergency Coolant Injection system, is currently being retro-fitted to Bruce ''A''. (iii) The implementation of process trips on the CANDU 600 design using microcomputers. While not truly a retrofit, this feature was added very late in the design cycle to increase the margin against spurious trips, and has now seen about 4 unit-years of service at three separate sites. Committed future applications of computers in special safety systems are also described. (author)

  16. Organogels thermodynamics, structure, solvent role, and properties

    CERN Document Server

    Guenet, Jean-Michel

    2016-01-01

    This book provides a physics-oriented introduction to organogels with a comparison to polymer thermoreversible gels whenever relevant. The past decade has seen the development of a wide variety of newly-synthesized molecules that can spontaneously self-assemble or crystallize from their organic or aqueous solutions to produce fibrillar networks, namely organogels, with potential applications in organic electronics, light harvesting, bio-imaging, non-linear optics, and the like. This compact volume presents a detailed outlook of these novel molecular systems with special emphasis upon their thermodynamics, morphology, molecular structure, and rheology. The definition of these complex systems is also tackled, as well as the role of the solvent. The text features numerous temperature-phase diagrams for a variety of organogels as well as illustrations of their structures at the microscopic, mesoscopic and macroscopic level. A review of some potential applications is provided including hybrid functional materials ...

  17. Supporting the scholar role in intensive care nursing.

    Science.gov (United States)

    Melles, M; Freudenthal, A; de Ridder, H

    2012-01-01

    This study investigates how future informatics applications can support and challenge intensive care nurses (ICU nurses) to grow and learn continuously. To this end a research-and-design tool is introduced which is based on a model of the nursing process that starts from the idea that a nurse fulfills three different roles: the role of practitioner (using information immediately to base actions upon), the role of scholar (using information later on to learn from) and the role of human (coping with stress and dealing with emotions). In this paper the focus is on the scholar role. Twenty-eight intensive care staff members from six different hospitals were asked to recount an imposing experience from the perspective of each role. Regarding the scholar role, the participants mentioned 77 learning strategies they adopt for individual as well as organizational learning. Individual learning concerned reflection on former patient cases, reflection on current patient cases to anticipate a change in the patient's condition and reflection on personal behavior and decisions. Organizational learning concerned reflection on former patient cases. Examples of specific strategies were formal team evaluations focused on procedure and understanding the perspective of team members, being present at autopsies, and giving feedback on the nursing skills of colleagues. Based on these strategies design implications are defined for future nursing informatics applications, which will be presented.

  18. Neuroendocrine Role for VGF

    Directory of Open Access Journals (Sweden)

    Jo Edward Lewis

    2015-02-01

    Full Text Available The vgf gene (non-acronymic is highly conserved and was identified on the basis of its rapid induction in vitro by nerve growth factor, although can also be induced by brain derived neurotrophic factor, and glial derived growth factor. The VGF gene gives rise to a 68kDa precursor polypeptide which is induced robustly, relatively selectively and is synthesized exclusively in neuronal and neuroendocrine cells. Post-translational processing by neuroendocrine specific pro-hormone convertases in these cells results in the production of a number of smaller peptides. The VGF gene and peptides are widely expressed throughout the brain, particularly the hypothalamus and hippocampus, and in peripheral tissues including the pituitary gland, the adrenal glands and the pancreas, and in the gastrointestinal tract in both the myenteric plexus and in endocrine cells. VGF peptides have been associated with a number of neuroendocrine roles and in this mini-review we aim to describe these roles to highlight the importance of VGF as therapeutic target for a number of disorders, particularly those associated with energy metabolism, pain, reproduction and cognition.

  19. Topology Optimization - broadening the areas of application

    DEFF Research Database (Denmark)

    Bendsøe, Martin P.; Lund, Erik; Olhoff, Niels

    2005-01-01

    This paper deals with recent developments of topology optimization techniques for application in some new types of design problems. The emphasis is on recent work of the Danish research groups at Aalborg University and at the Technical University of Denmark and focus is on the central role that t...

  20. Mathematical Ship Modeling for Control Applications

    DEFF Research Database (Denmark)

    Perez, Tristan; Blanke, Mogens

    2002-01-01

    In this report, we review the models for describing the motion of a ship in four degrees of freedom suitable for control applications. We present the hydrodynamic models of two ships: a container and a multi-role naval vessel. The models are based on experimental results in the four degrees...

  1. Clinical application of ghrelin.

    Science.gov (United States)

    Strasser, Florian

    2012-01-01

    Ghrelin as a human natural hormone is involved in fundamental regulatory processes of eating and energy balance. Ghrelin signals the nutrient availability from the gastrointestinal tract to the central nervous system, up-regulates food intake and lowers energy expenditure mainly through hypothalamic mediators acting both centrally and peripherally including the gastrointestinal tract (motility, epithelium), promotes both neuro-endocrine and inflammatory signals to increase skeletal muscle growth and decrease protein breakdown, and increases lipolysis while body fat utilization is reduced. Ghrelin does more to exert its probably sentinel role around "human energy": it influences through mainly extra-hypothalamic actions the hedonic and incentive value of food, mood and anxiety, sleep-wake regulation, learning and memory, and neurogenesis. Recently numerous ghrelin gene-derived peptides were discovered, demonstrating the complexity within the ghrelin/ghrelin receptor axis. For clinical applications, not only the natural ghrelin and its slice variants, but also several modified or artificial molecules acting at ghrelin-associated receptors were and are developed. Current clinical applications are limited to clinical studies, focusing mainly on cachexia in chronic heart failure, COPD, cancer, endstage- renal-disease or cystic fibrosis, but also on frailty in elderly, gastrointestinal motility (e.g., gastroparesis, functional dyspepsia, postoperative ileus), after curative gastrectomy, anorexia nervosa, growth hormone deficient patients, alcohol craving, sleep-wake regulation (e.g. major depression), or sympathetic nervous activity in obesity. The results of completed, preliminary studies support the clinical potential of ghrelin, ghrelin gene-derived peptides, and artificial analogues, suggesting that larger clinical trials are demanded to move ghrelin towards an available and reimbursed pharmaceutical intervention.

  2. The Role of CFD Simulation in Rocket Propulsion Support Activities

    Science.gov (United States)

    West, Jeff

    2011-01-01

    Outline of the presentation: CFD at NASA/MSFC (1) Flight Projects are the Customer -- No Science Experiments (2) Customer Support (3) Guiding Philosophy and Resource Allocation (4) Where is CFD at NASA/MSFC? Examples of the expanding Role of CFD at NASA/MSFC (1) Liquid Rocket Engine Applications : Evolution from Symmetric and Steady to 3D Unsteady (2)Launch Pad Debris Transport-> Launch Pad Induced Environments (a) STS and Launch Pad Geometry-steady (b) Moving Body Shuttle Launch Simulations (c) IOP and Acoustics Simulations (3)General Purpose CFD Applications (4) Turbomachinery Applications

  3. Roles in Innovative Software Teams

    DEFF Research Database (Denmark)

    Aaen, Ivan

    2010-01-01

    With inspiration from role-play and improvisational theater, we are developing a framework for innovation in software teams called Essence. Based on agile principles, Essence is designed for teams of developers and an onsite customer. This paper reports from teaching experiments inspired by design...... science, where we tried to assign differentiated roles to team members. The experiments provided valuable insights into the design of roles in Essence. These insights are used for redesigning how roles are described and conveyed in Essence....

  4. Mobile phone application for mathematics learning

    Science.gov (United States)

    Supandi; Ariyanto, L.; Kusumaningsih, W.; Aini, A. N.

    2018-03-01

    This research was aimed to determine the role of the use of Mobile Phone Application (MPA) in Mathematics learning. The Pre and Post-test Quasy Experiment method was applied. The Pre-test was performed to understand the initial capability. In contrast, the Post-test was selected to identify changes in student ability after they were introduced to the application of Mobile Technology. Student responses to the use of this application were evaluated by a questionnaire. Based on the questionnaire, high scores were achieved, indicating the student's interest in this application. Also, learning results showed significant improvement in the learning achievement and the student learning behaviour. It was concluded that education supported by the MPA application gave a positive impact on learning outcomes as well as learning atmosphere both in class and outside the classroom.

  5. Biomedical hydrogels biochemistry, manufacture and medical applications

    CERN Document Server

    Rimmer, Steve

    2011-01-01

    Hydrogels are very important for biomedical applications because they can be chemically manipulated to alter and control the hydrogel's interaction with cells and tissues. Their flexibility and high water content is similar to that of natural tissue, making them extremely suitable for biomaterials applications. Biomedical hydrogels explores the diverse range and use of hydrogels, focusing on processing methods and novel applications in the field of implants and prostheses. Part one of this book concentrates on the processing of hydrogels, covering hydrogel swelling behaviour, superabsorbent cellulose-based hydrogels and regulation of novel hydrogel products, as well as chapters focusing on the structure and properties of hydrogels and different fabrication technologies. Part two covers existing and novel applications of hydrogels, including chapters on spinal disc and cartilage replacement implants, hydrogels for ophthalmic prostheses and hydrogels for wound healing applications. The role of hydrogels in imag...

  6. Completing the surrogate motherhood process: parental order reporters' attitudes towards surrogacy arrangements, role ambiguity and role conflict.

    Science.gov (United States)

    Purewal, Satvinder; Crawshaw, Marilyn; van den Akker, Olga

    2012-06-01

    This study investigated the attitudes of parental order reporters (PORs) towards their work with surrogacy arrangements and their experiences of role conflict and role ambiguity. A questionnaire was used to assess PORs' perceptions of their role in parental order [PO] applications, attitudes towards surrogacy arrangements and the legal process and the influence of role ambiguity or conflict. Questionnaires were distributed to all PORs employed by the Children and Family Court Advisory and Support Service in England. Thirty-three PORs participated (response rate 46%) who, on average, had each completed five PO applications (range 1-40). Positive attitudes towards surrogacy and the child's needs for openness about origins were found. Concerns about the inadequacy of preparation and assessment arrangements, overseas arrangements and non-regulation of surrogacy agencies were evident. PORs with high-role ambiguity were more likely to report less positive attitudes towards the emotional consequence of surrogacy on offspring. High scores on role ambiguity and role conflict were reflected in less positive attitudes towards the parties' preparation towards parenthood. These results have implications for training, policy and practice in this area.

  7. Learning Android application testing

    CERN Document Server

    Blundell, Paul

    2015-01-01

    If you are an Android developer looking to test your applications or optimize your application development process, then this book is for you. No previous experience in application testing is required.

  8. Promise Zones for Applicants

    Data.gov (United States)

    Department of Housing and Urban Development — This tool assists applicants to HUD's Promise Zone initiative prepare data to submit with their application by allowing applicants to draw the exact location of the...

  9. Radiation chemistry and its application

    International Nuclear Information System (INIS)

    Majima, Tetsuro

    2013-01-01

    Effects of radiation to human body have been seriously discussed nowadays. These are important issues for the realization of sustainable society. It should be emphasized that various reactive intermediates generated by radiation play important roles in each cases. Radiation chemical studies will provide various reaction-mechanistic aspects on these important issues. Our research group has continuously carried out reaction-mechanistic studies using radiation chemical methods. From these studies, we have obtained a variety of results on basic molecular systems, reactions, materials that are close to practical application, biological systems and so on. Reactive species are generated from the radiation reactions in solution, and can be used as one-electron oxidative and reductive reagent to give selectively radical cation and anion of solute molecules such as various organic and inorganic molecules. Therefore, the radiation chemistry has contributed significantly to chemistry in which one-electron oxidation and reduction play the important role. The kinetics of such redox processes and the following reduction play the important role. The kinetics of such redox processes and the following reactions can be studied in real time with the transition absorption measurement by the pulse radiolysis technique. Even though the target compounds cannot be oxidized and reduced in chemical or electrochemical oxidation and reduction, their one-electron redox can be performed by the electron beam radiation. Therefore, radiation chemistry is very useful technique for basic science. Moreover, application potentials of radiation chemistry are so high for various research subjects. Moreover, application potentials of radiation chemistry are so high for various research subjects

  10. Efficiency of PRECIS Role Operators.

    Science.gov (United States)

    Mahapatra, M.; Biswas, S. C.

    1984-01-01

    Describes research which measured the efficiency of role operators through frequency of appearances in PRECIS input strings for 200 abstracts related to taxation, genetic psychology, and Shakespearian drama. Frequencies of appearance of major categories of role operators, role operators in different subjects, individual main line operators, and…

  11. Studies of blood irradiator application

    International Nuclear Information System (INIS)

    Li Wenhong; Lu Yangqiao

    2004-01-01

    Transfusion is an important means for medical treatment, but it has many syndromes such as transfusion-associated graft-versus-host disease, it's occurrence rate of 5% and above 90% death-rate. Now many experts think the only proven method is using blood irradiator to prevent this disease. It can make lymphocyte of blood product inactive, so that it can not attack human body. Therefore, using irradiation blood is a trend, and blood irradiator may play an important role in medical field. This article summarized study of blood irradiator application, including the meaning of blood irradiation, selection of the dose for blood irradiation and so on

  12. Industrial Applications of Image Processing

    Science.gov (United States)

    Ciora, Radu Adrian; Simion, Carmen Mihaela

    2014-11-01

    The recent advances in sensors quality and processing power provide us with excellent tools for designing more complex image processing and pattern recognition tasks. In this paper we review the existing applications of image processing and pattern recognition in industrial engineering. First we define the role of vision in an industrial. Then a dissemination of some image processing techniques, feature extraction, object recognition and industrial robotic guidance is presented. Moreover, examples of implementations of such techniques in industry are presented. Such implementations include automated visual inspection, process control, part identification, robots control. Finally, we present some conclusions regarding the investigated topics and directions for future investigation

  13. UML 2 Semantics and Applications

    CERN Document Server

    Lano, Kevin

    2009-01-01

    A coherent and integrated account of the leading UML 2 semantics work and the practical applications of UML semantics development With contributions from leading experts in the field, the book begins with an introduction to UML and goes on to offer in-depth and up-to-date coverage of: The role of semantics Considerations and rationale for a UML system model Definition of the UML system model UML descriptive semantics Axiomatic semantics of UML class diagrams The object constraint language Axiomatic semantics of state machines A coalgebraic semantic framework for reasoning about interaction des

  14. Random measures, theory and applications

    CERN Document Server

    Kallenberg, Olav

    2017-01-01

    Offering the first comprehensive treatment of the theory of random measures, this book has a very broad scope, ranging from basic properties of Poisson and related processes to the modern theories of convergence, stationarity, Palm measures, conditioning, and compensation. The three large final chapters focus on applications within the areas of stochastic geometry, excursion theory, and branching processes. Although this theory plays a fundamental role in most areas of modern probability, much of it, including the most basic material, has previously been available only in scores of journal articles. The book is primarily directed towards researchers and advanced graduate students in stochastic processes and related areas.

  15. Stable isotopes - separation and application

    International Nuclear Information System (INIS)

    Lockhart, I.M.

    1980-01-01

    In this review, methods used for the separation of stable isotopes ( 12 C, 13 C, 14 N, 15 N, 16 O, 17 O, 18 O, 34 S) will be described. The synthesis of labelled compounds, techniques for detection and assay, and areas of application will also be discussed. Particular attention will be paid to the isotopes of carbon, nitrogen, and oxygen; to date, sulphur isotopes have only assumed a minor role. The field of deuterium chemistry is too extensive for adequate treatment; it will therefore be essentially excluded. (author)

  16. Association models for petroleum applications

    DEFF Research Database (Denmark)

    Kontogeorgis, Georgios

    2013-01-01

    Thermodynamics plays an important role in many applications in the petroleum industry, both upstream and downstream, ranging from flow assurance, (enhanced) oil recovery and control of chemicals to meet production and environmental regulations. There are many different applications in the oil & gas...... industry, thus thermodynamic data (phase behaviour, densities, speed of sound, etc) are needed to study a very diverse range of compounds in addition to the petroleum ones (CO2, H2S, water, alcohols, glycols, mercaptans, mercury, asphaltenes, waxes, polymers, electrolytes, biofuels, etc) within a very....... Such association models have been, especially over the last 20 years, proved to be very successful in predicting many thermodynamic properties in the oil & gas industry. They have not so far replaced cubic equations of state, but the results obtained by using these models are very impressive in many cases, e...

  17. Modern measurements fundamentals and applications

    CERN Document Server

    Petri, D; Carbone, P; Catelani, M

    2015-01-01

    This book explores the modern role of measurement science for both the technically most advanced applications and in everyday and will help readers gain the necessary skills to specialize their knowledge for a specific field in measurement. Modern Measurements is divided into two parts. Part I (Fundamentals) presents a model of the modern measurement activity and the already recalled fundamental bricks. It starts with a general description that introduces these bricks and the uncertainty concept. The next chapters provide an overview of these bricks and finishes (Chapter 7) with a more general and complex model that encompasses both traditional (hard) measurements and (soft) measurements, aimed at quantifying non-physical concepts, such as quality, satisfaction, comfort, etc. Part II (Applications) is aimed at showing how the concepts presented in Part I can be usefully applied to design and implement measurements in some very impor ant and broad fields. The editors cover System Identification (Chapter 8...

  18. EURATOM: Development, role, experience

    International Nuclear Information System (INIS)

    Tsalas, S.

    1998-01-01

    Besides description of the historical development of EURATOM and its role in safeguards the paper includes the implementation experience of EURATOM safeguards. Depending on the scope of inspection a set of measures is applied according to the following verification methods: accountancy audit, visual checks, counting and identification, non-destructive measurements, sampling and destructive analysis complemented by containment and surveillance measures. The present staff of the safeguards directorate comprises about 300 persons of which two thirds are inspectors. EURATOM has a solid legal basis for performing safeguards inspections and the necessary infrastructure for inspection support, information treatment and data evaluation. It is a full scope multinational regional safeguards system fulfilling its obligations under EURATOM Treaty and contributing to the successful implementation of the Non-proliferation treaty by satisfying its obligations in the framework of the safeguards agreements with the IAEA

  19. Women in Leading Role

    Directory of Open Access Journals (Sweden)

    Rácz Anita

    2016-11-01

    Full Text Available The questions related to the role of women in the world of labour and to the rate of female and male employees are issues that have been discussed since long ago. Equality of women and the fight against the discrimination of women are hot topics not only for the “weaker sex” as there are abundant research and literature dealing with the question whether feminism, the lengthy pursuit for the equality of women can be regarded successful or there are still much to do for the elimination of negative discrimination of women at workplaces. In this context, I examine in my study whether the increasing of the share of female employees, the action plans on raising the share of executive positions filled by women, and the related conferences live up to the expectations, and can women really have the same place on the labour market as men have.

  20. Sustainability: role of thorium

    International Nuclear Information System (INIS)

    Stigson, Bjorn Roland

    2015-01-01

    The task to renew the world's energy infrastructure, where fossil fuels account for 80% of supply, is enormous. The two carbon neutral energy sources - renewable and nuclear - should be the base of the world's future energy mix. Nuclear, however, suffers from a bad public opinion and lack of government support in many parts of the world. We can conclude that the world needs an 'on demand' energy source that is affordable, clean, safe and scalable. Thorium energy could be that energy source. It is the most energy dense solution we know, fitting well to the modular and size-constrained requirements of an urbanizing world. No part of society can create a sustainable world on their own and markets are too slow to drive transformational changes. We need new partnerships between governments, business, civil society and academia where each part is delivering on their specific responsibilities and roles

  1. Dementia: role of MRI

    International Nuclear Information System (INIS)

    Georgieva-Kozarova, G.

    2012-01-01

    Full text: This presentation will focus on the role of MRI in the diagnosis of dementia and related diseases. We will discuss the following subjects: 1. Systematic assessment of MR in dementia 2. MR protocol for dementia 3. Typical findings in the most common dementia syndrome Alzheimer's disease (AD), Vascular Dementia (VaD), Frontotemporal lobe dementia (FTLD) 4. Short overview of neurodegenerative disorders which may be associated with dementia. The role of neuroimaging in dementia nowadays extends to support the diagnosis of specific neurodegenerative disorders. It is a challenge to the early diagnosis of neurodegenerative diseases such as Alzheimer's disease. Early diagnosis includes recognition of predementia conditions, such as mild cognitive impairment (MCI). Neuroimaging may also be used to assess disease progression and is adopted in current trials investigating MCI and AD. An MR-study of a patient suspected of having dementia must be assessed in a standardized way. First of all, treatable diseases like subdural hematomas, tumors and hydrocephalus need to be excluded. Next we should look for signs of specific dementias such as: Alzheimer's disease (AD): medial temporal lobe atrophy (MTA) and parietal atrophy. Frontotemporal Lobar Degeneration (FTLD): (asymmetric) frontal lobe atrophy and atrophy of the temporal pole. Vascular Dementia (VaD): global atrophy, diffuse white matter lesions, lacunas and 'strategic infarcts' (infarcts in regions that are involved in cognitive function). Dementia with Lewy bodies (DLB): in contrast to other forms of dementia usually no specific abnormalities. So when we study the MR images we should score in a systematic way for global atrophy, focal atrophy and for vascular disease (i.e. infarcts, white matter lesions, lacunas)

  2. Credential Application Awaiting Information

    Data.gov (United States)

    Department of Homeland Security — When a Credential application or required documentation is incomplete, an Awaiting Information letter is issued. The application process cannot continue until all...

  3. Role of mass spectrometry in nuclear forensic science

    International Nuclear Information System (INIS)

    Joseph, M.; Sivaraman, N.

    2016-01-01

    The present talk will focus on the role of mass spectrometry in NFS in general; besides that, the various chromatographic methods developed towards separation of actinides and lanthanide fission products and characterization of dissolver solutions of nuclear reactor fuels using TIMS and some applications of using ICP-MS as well

  4. The role of computed tomography in modern paediatric uroradiology

    International Nuclear Information System (INIS)

    Maudgil, D.D.; McHugh, K.

    2002-01-01

    Computed tomography (CT) has developed a well-recognised role within paediatric uroradiology, especially in imaging of trauma, malignancy (in particular Wilms' tumour), atypical infection, and congenital urogenital abnormalities. CT can also be used for problem solving in nephrolithiasis and renal transplant assessment. These applications are illustrated and discussed, with an emphasis on particular information that can be gained from the CT study

  5. A Recruiting and Hiring Role-Play: An Experiential Simulation

    Science.gov (United States)

    Newberry, Robert; Collins, Marianne K.

    2012-01-01

    Creating experiential learning opportunities that engage students, meet marketing curricula objectives, and fit the application in a traditional semester course is extremely challenging. This paper describes a role-playing simulation offered concurrently to the professional selling and sales management classes in which the selling students act as…

  6. Energy in developing countries and the role of nuclear energy

    International Nuclear Information System (INIS)

    Goldemberg, Jose

    1986-01-01

    The role of nuclear energy in developing countries is discussed with respect to energy consumption, energy needs and energy future. The application of Article IV of the Non-Proliferation Treaty (NPT) is examined for the developing countries. It is suggested that a revision of the NPT is needed to encourage effective nuclear disarmament. (UK)

  7. Partons and their applications at high energies

    International Nuclear Information System (INIS)

    Drell, Sidney D.; Yan, Tung-Mow

    2000-01-01

    We discuss Feynman's parton model for deep inelastic weak or electromagnetic processes as an application of the impulse approximation to elementary particle interactions. The special features and conditions permitting this application are elaborated upon in some detail including the dependence of the parton model and the impulse treatment on an appropriate choice of coordinate frames and the role of the very soft or wee partons. Application of the parton model is made to the calculation of the cross section for massive lepton pair production in very high energy hadron-hadron collisions and compared with experiment. The conjectured role of light cone singularities in describing this and the other deep inelastic amplitudes is also discussed. (c) 2000 Academic Press, Inc

  8. Radioanalytical techniques and their application in forensic science

    International Nuclear Information System (INIS)

    Chattopadhyay, N.

    1998-01-01

    Neutron techniques mainly in the form of Neutron Activation Analysis (NAA) is suitable for determination of very low amounts of many elements and can be effectively applied in crime investigation. Trace element analysis plays a significant role in forensic science. Different aspects of radioanalytical techniques, role of a few typical elements and their forensic application in different types of samples are discussed

  9. Use of professional profiles in applications for specialist training positions

    DEFF Research Database (Denmark)

    Lundh, Andreas; Skjelsager, Karen; Wildgaard, Kim

    2013-01-01

    The seven roles of the CanMEDS system have been implemented in Danish postgraduate medical training. For each medical specialty, a professional profile describes which elements of the seven roles the specialty deems important for applicants for a specialist training position. We investigated use...

  10. The role of benchmarking for yardstick competition

    International Nuclear Information System (INIS)

    Burns, Phil; Jenkins, Cloda; Riechmann, Christoph

    2005-01-01

    With the increasing interest in yardstick regulation, there is a need to understand the most appropriate method for realigning tariffs at the outset. Benchmarking is the tool used for such realignment and is therefore a necessary first-step in the implementation of yardstick competition. A number of concerns have been raised about the application of benchmarking, making some practitioners reluctant to move towards yardstick based regimes. We assess five of the key concerns often discussed and find that, in general, these are not as great as perceived. The assessment is based on economic principles and experiences with applying benchmarking to regulated sectors, e.g. in the electricity and water industries in the UK, The Netherlands, Austria and Germany in recent years. The aim is to demonstrate that clarity on the role of benchmarking reduces the concern about its application in different regulatory regimes. We find that benchmarking can be used in regulatory settlements, although the range of possible benchmarking approaches that are appropriate will be small for any individual regulatory question. Benchmarking is feasible as total cost measures and environmental factors are better defined in practice than is commonly appreciated and collusion is unlikely to occur in environments with more than 2 or 3 firms (where shareholders have a role in monitoring and rewarding performance). Furthermore, any concern about companies under-recovering costs is a matter to be determined through the regulatory settlement and does not affect the case for using benchmarking as part of that settlement. (author)

  11. Possible roles for mismatch negativity in neuropsychiatry.

    Science.gov (United States)

    Gené-Cos, N; Ring, H A; Pottinger, R C; Barrett, G

    1999-01-01

    This article reviews research on the main characteristics of mismatch negativity (MMN) and its applications in neuropsychiatry. Event-related potentials (ERPs) have been used to study many aspects of information processing. Mismatch negativity is an early auditory ERP that has been identified as an index of an automatic (preconscious) alerting mechanism stimulating an individual to attend to unexpected environmental events. Disturbances of MMN may relate to abnormalities of auditory information processing contributing to the pathophysiology of neuropsychiatric conditions. The authors review (1) studies that have evaluated the electrophysiological aspects of MMN and (2) studies that have investigated the different applications of MMN in neuropsychiatry. The first part of this article describes the characteristics of MMN, its cerebral origins, and electrophysiological parameters. We then discuss the role of "echoic memory" as well as that of attention and vigilance. In the second part of the article, disturbances in MMN associated with schizophrenia, depressive illness, dementing processes, and other neuropsychiatric states are discussed. MMN is a preconscious cognitive ERP, the main generators and functions of which are well defined. Observations relating to the origins of MMN and its role in early auditory information processing together with its possible behavioral significance, combined with observations of MMN aberrations in psychiatric conditions, may provide novel insights into the pathophysiology of neuropsychiatric states.

  12. Computational quantum magnetism: Role of noncollinear magnetism

    International Nuclear Information System (INIS)

    Freeman, Arthur J.; Nakamura, Kohji

    2009-01-01

    We are witnessing today a golden age of innovation with novel magnetic materials and with discoveries important for both basic science and device applications. Computation and simulation have played a key role in the dramatic advances of the past and those we are witnessing today. A goal-driving computational science-simulations of every-increasing complexity of more and more realistic models has been brought into greater focus with greater computing power to run sophisticated and powerful software codes like our highly precise full-potential linearized augmented plane wave (FLAPW) method. Indeed, significant progress has been achieved from advanced first-principles FLAPW calculations for the predictions of surface/interface magnetism. One recently resolved challenging issue is the role of noncollinear magnetism (NCM) that arises not only through the SOC, but also from the breaking of symmetry at surfaces and interfaces. For this, we will further review some specific advances we are witnessing today, including complex magnetic phenomena from noncollinear magnetism with no shape approximation for the magnetization (perpendicular MCA in transition-metal overlayers and superlattices; unidirectional anisotropy and exchange bias in FM and AFM bilayers; constricted domain walls important in quantum spin interfaces; and curling magnetic nano-scale dots as new candidates for non-volatile memory applications) and most recently providing new predictions and understanding of magnetism in novel materials such as magnetic semiconductors and multi-ferroic systems

  13. The role of dimethylaminoethanol in cosmetic dermatology.

    Science.gov (United States)

    Grossman, Rachel

    2005-01-01

    Skincare formulations for the improvement of aging skin are increasingly important consumer products. Here, we review available data on one such agent - 2-dimethylaminoethanol (DMAE) or deanol - that has recently been evaluated in a placebo-controlled trial. DMAE is an analog of the B vitamin choline and is a precursor of acetylcholine. Although the role of acetylcholine as a neurotransmitter is well known, growing evidence points to acetylcholine as a ubiquitous cytokine-like molecule that regulates basic cellular processes such as proliferation, differentiation, locomotion, and secretion in a paracrine and autocrine fashion. Indeed, this modulatory role may contribute to the cutaneous activity of DMAE. In a randomized clinical study, 3% DMAE facial gel applied daily for 16 weeks has been shown to be safe and efficacious (p appearance of aging skin. These effects did not regress during a 2-week cessation of application. Beneficial trends (p > 0.05 but appearance of coarse wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness. Application was found to be well tolerated, with no differences in the incidence of erythema, peeling, dryness, itching, burning, or stinging between the DMAE and placebo groups. An open-label extension of the trial showed that the long-term application of DMAE gel for up to 1 year was associated with a good safety profile. The acute skin-firming effects of DMAE have been confirmed by quantitative measures of cutaneous tensile strength. In vitro studies in peripheral blood lymphocytes indicate that DMAE is a moderately active anti-inflammatory agent. Although its mechanisms of action in the skin remain to be elucidated, evidence suggests that the skin is an active site of acetylcholine synthesis, storage, secretion, metabolism, and receptivity. Muscarinic acetylcholine receptors have been localized to keratinocytes, melanocytes and dermal fibroblasts, whereas nicotinic acetylcholine receptors have been found

  14. Characteristics and Thinking of External Application of Chinese Medicine

    Science.gov (United States)

    Li, Mengyan; Bai, Ming; Miao, Mingsan

    2018-01-01

    Chinese traditional medicine plays an important role in the clinical treatment of traditional Chinese medicine topical drugs in recent years with the increasing types of disease treatment is also not much extended, this paper reviews the application of clinical application of traditional Chinese medicine in recent years in different conditions, to provide reference for related research.

  15. Connecting NASA science and engineering with earth science applications

    Science.gov (United States)

    The National Research Council (NRC) recently highlighted the dual role of NASA to support both science and applications in planning Earth observations. This Editorial reports the efforts of the NASA Soil Moisture Active Passive (SMAP) mission to integrate applications with science and engineering i...

  16. The role of heart rate variability in sports physiology.

    Science.gov (United States)

    Dong, Jin-Guo

    2016-05-01

    Heart rate variability (HRV) is a relevant marker reflecting cardiac modulation by sympathetic and vagal components of the autonomic nervous system (ANS). Although the clinical application of HRV is mainly associated with the prediction of sudden cardiac death and assessing cardiovascular and metabolic illness progression, recent observations have suggested its applicability to physical exercise training. HRV is becoming one of the most useful tools for tracking the time course of training adaptation/maladaptation of athletes and in setting the optimal training loads leading to improved performances. However, little is known regarding the role of HRV and the internal effects of physical exercise on an athlete, which may be useful in designing fitness programs ensuring sufficient training load that may correspond with the specific ability of the athlete. In this review, we offer a comprehensive assessment of investigations concerning the interrelation between HRV and ANS, and examine how the application of HRV to physical exercise may play a role in sports physiology.

  17. Tüketimin Değişen Yüzü: Elektronik Ticaret Uygulamaları ve Sosyal Paylaşım Ağlarının Rolü / The Changing Face of Consumption: E-Commerce Applications And The Role of Social Networks

    Directory of Open Access Journals (Sweden)

    Büşra Halis

    2012-12-01

    Full Text Available İnsanlık tarihi kadar eski olan tüketim, zaman içerisinde yaşanan değişim ve dönüşümlerle birlikte yeni bir boyut kazanmıştır. Eskinin, ihtiyacı kadar almak ve çalışmak gibi fenemonlerinin yerini, günümüzde daha çok satın almak için çalışmak, tükettiğinin ölçüsünde var olabilmek ya da olamamak almıştır. Tüketimin soyut anlamda kavramsal içeriğinin farklılaşmasının yanı sıra, tüketim araçları da farklılaşmıştır. Artık, yüz yüze görüşmeler yoluyla yapılan alışverişlerin yerini; fiziki mekândan bağımsız, internet üzerinden e-ticaret yoluyla ve birtakım paylaşım ağları aracılığıyla yapılan alışverişler almıştır. Bu çalışmada da, tüketimin ve tüketimde kullanılan araçların geçmişten bugüne değişen anlamı ve bu değişimi körükleyen sosyal ağ paradigması tartışılmaktadır. The Changing Face of Consumption: E-Commerce Applications And The Role of Social Networks Consumption, which is as old as human history has gained a new dimension with changes and transformations in the course of time. In the past, people bought and worked as they needed, but now, they work to buy more things except necessity and they be or not to be until they consumed. Over time, the conceptual content and tools of the consumption has changed. Shopping, which is done independent of the physical space, via the internet through e-commerce replaced shopping made by face to face. In this work, the changing meaning and tools of consumption from past to present and the paradigm of social networks which encouraging this change is to be held.

  18. Sight Application Analysis Tool

    Energy Technology Data Exchange (ETDEWEB)

    Bronevetsky, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-09-17

    The scale and complexity of scientific applications makes it very difficult to optimize, debug and extend them to support new capabilities. We have developed a tool that supports developers’ efforts to understand the logical flow of their applications and interactions between application components and hardware in a way that scales with application complexity and parallelism.

  19. CENTRAL EUROPE: Role models

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1993-12-15

    Hungary is one of the newcomers to the CERN fold, having joined in 1992. The country's contributions are naturally in line with its slender resources and are not as immediately visible as those of the major Western European Member States. However the approach used and its consequent successes provide a good role model for a smaller nation in an international research environment. This was reflected on 24 September at a meeting of the European Committee for Future Accelerators (ECFA) convened in Budapest, continuing an ECFA tradition of holding meetings in national centres to learn more about the physics programmes of different countries. This tradition started with visits to major West European Centres, but last year ECFA held a meeting in Warsaw, its first in a central European country. By far the largest Hungarian population centre, Budapest is also a hub for national research in this sector, with university centres and the KFKI Research Institute for Particle and Nuclear Physics of the National Academy of Sciences. However important research work is also carried out in the eastern city of Debrecen. Hungarians look back to the classic investigations of Eotvos early this century as the starting point of their national tradition in fundamental physics. (In the mid-80s, these experiments briefly came back into vogue when there was a suggestion of an additional 'fifth force' contribution to nuclear masses.)

  20. CENTRAL EUROPE: Role models

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    Hungary is one of the newcomers to the CERN fold, having joined in 1992. The country's contributions are naturally in line with its slender resources and are not as immediately visible as those of the major Western European Member States. However the approach used and its consequent successes provide a good role model for a smaller nation in an international research environment. This was reflected on 24 September at a meeting of the European Committee for Future Accelerators (ECFA) convened in Budapest, continuing an ECFA tradition of holding meetings in national centres to learn more about the physics programmes of different countries. This tradition started with visits to major West European Centres, but last year ECFA held a meeting in Warsaw, its first in a central European country. By far the largest Hungarian population centre, Budapest is also a hub for national research in this sector, with university centres and the KFKI Research Institute for Particle and Nuclear Physics of the National Academy of Sciences. However important research work is also carried out in the eastern city of Debrecen. Hungarians look back to the classic investigations of Eotvos early this century as the starting point of their national tradition in fundamental physics. (In the mid-80s, these experiments briefly came back into vogue when there was a suggestion of an additional 'fifth force' contribution to nuclear masses.)

  1. Role of the technologist

    International Nuclear Information System (INIS)

    Bray, A.P.

    1985-01-01

    This paper discusses the role of the technologist in helping achieve all the objectives of the nuclear project - not only the technical objectives, but the business and societal objectives as well. It is important to realize at the outset the many objectives that the project can fulfill, including the contribution it can make to national development. The technologist may act as consultant, a partner, a business administrator or an agent of the utility, helping implement a management approach that furthers not only technical, but business and societal objectives as well. Two very different approaches to contracting are possible. On the one hand, the utility places heavy pressure on bidders to accept the risk of schedule and license, and forces suppliers to charge higher prices and make little use of local talent. On the other hand, the utility may recognize the need to develop national capability in the nuclear industry, and accept cooperative contracts which encourage suppliers to foster and employ local talent. This issue must be given attention in the initiation of future national nuclear power programs: whether to minimize the cost of the plant or maximize the cultivation and development of national capability

  2. The roles of turbulence on plasma heating

    International Nuclear Information System (INIS)

    Kawamura, Takaichi; Kawabe, Takaya.

    1976-06-01

    In this paper, the characteristic features of the turbulent heating are reviewed, which is considered to be one of the strong candidates of the further heating method in fusion reactor systems, referring to the works in the Institute of Plasma Physics, Nagoya University. The roles of turbulence in plasma heating including toroidal plasma heating are discussed from several points of view. The relation between the heating rate of plasma particles and the thermalization (randomization) frequency is theoretically investigated and the role of plasma turbulence in the fast thermalization is shown. The experimental results on fluctuation and heating of electrons and ions in turbulently heated plasmas are presented. The influence of turbulence, which is responsible for the particle heating, on the diffusion across the confinement magnetic field is considered for the application in the toroidal plasmas. It is pointed out that the turbulent fields in the fast turbulent heating give only a minor effect to the loss of particles across the magnetic field. It can be said that the enhanced fluctuation in turbulent plasma gives its field energy to the plasma particles while it can play the role of the fast thermalization of the ordered motion of particles that is produced in the plasma by some acceleration process. (Kato, T.)

  3. Management information systems: their role in the marketing activities of HMOs.

    Science.gov (United States)

    Aronow, D B

    1988-01-01

    HMOs are particularly dependent on their information resources in providing cost-effective, high quality, accessible care. Understanding the role of MIS in HMO marketing activities may guide administrators in evaluating information systems applications within their organizations.

  4. Application of Java technology in radiation image processing

    International Nuclear Information System (INIS)

    Cheng Weifeng; Li Zheng; Chen Zhiqiang; Zhang Li; Gao Wenhuan

    2002-01-01

    The acquisition and processing of radiation image plays an important role in modern application of civil nuclear technology. The author analyzes the rationale of Java image processing technology which includes Java AWT, Java 2D and JAI. In order to demonstrate applicability of Java technology in field of image processing, examples of application of JAI technology in processing of radiation images of large container have been given

  5. Thin film coatings for space electrical power system applications

    Science.gov (United States)

    Gulino, Daniel A.

    1988-01-01

    This paper examines some of the ways in which thin film coatings can play a role in aerospace applications. Space systems discussed include photovoltaic and solar dynamic electric power generation systems, including applications in environmental protection, thermal energy storage, and radiator emittance enhancement. Potential applications of diamondlike films to both atmospheric and space based systems are examined. Also, potential uses of thin films of the recently discovered high-temperature superconductive materials are discussed.

  6. Application of CFD technique for HYFLEX aerodynamic design

    OpenAIRE

    Yamamoto, Yukimitsu; Watanabe, Shigeya; Ishiguro, Mitsuo; Ogasawara, Ko; 山本 行光; 渡辺 重哉; 石黒 満津夫; 小笠原 宏

    1994-01-01

    An overview of the application of Computational Fluid Dynamics (CFD) technique for the HYFLEX (Hypersonic Flight Experiment) aerodynamic design by using the numerical simulation codes in the supersonic and hypersonic speed ranges is presented. Roles of CFD required to make up for the short term of development and small amount of the wind tunnel test cases, application in the HYFLEX aerodynamic design and their application methods are described. The procedure of CFD code validation by the expe...

  7. Inventory and application of artificial radionuclides in France

    International Nuclear Information System (INIS)

    Besson, J.P.; Hoorelbeke, A.

    1998-01-01

    A number of regulations were completed with the aim to ensure safe storage and application of radionuclides in France, especially taking into account radiation protection. CIREA guarantees their unanimity by its judgement on the general questions arising from application of regulations. It has a regulatory role since it requires special conditions for particular practices. Authorisation for induction of radioactive sources or equipment containing sources, their application, storage, etc. are directly given by CIREA or after having obtained its premises

  8. HIFAR's developing role

    International Nuclear Information System (INIS)

    Abraham, D.

    1992-01-01

    The High Flux Australian Reactor (HIFAR) is operated by the Australian Nuclear Science and Technology Organisation (ANSTO) with objectives associated with the non-energy uses of nuclear technology. HIFAR is one of six DIDO-class reactors designed in Britain in the 1950s. The design was chosen for its versatility, utility and longevity and has brought wide benefits to health care, to environmental protection and to the development of high technology. HIFAR is expected to be operating to the early years of the next century. After the government decided not to develop a nuclear power programme, materials testing work tapered off while the use of the reactor for producing radioisotopes increased. This growth continued to the point where radioisotope production became the major application of the reactor's in-core facilities. With the growth in the world semiconductor industry, ANSTO built facilities at HIFAR in the early 1980s to convert silicon to neutron transmutation doped (NTD) silicon for semiconductor manufacture. (Author)

  9. and their biological role

    Directory of Open Access Journals (Sweden)

    Agnieszka Zabłotni

    2014-08-01

    Full Text Available Nowadays antibiotics are broadly used not only for treatment of bacterial infections but also in nonmedical applications. For many years they have been added as livestock and poultry growth supplements, and they are applied similarly in fish farming. In basically unchanged form they may get into the natural environment and remain there for a long time. Excessive use of antibiotics leads to widespread of antibiotic resistance among clinical and environmental bacterial strains. Subinhibitory concentrations of antibiotics, which do not inhibit growth of bacteria, are often found in soil, water or even in the tissue of different organisms. Such low concentrations affect many bacterial genes through changes in their transcription level and increase of the mutation rate, and as a consequence lead to many bacterial adaptations to environmental stresses. There is also evidence that subinhibitory concentrations of antibiotics induce transfer of mobile genetic elements through horizontal gene transfer pathways, and therefore enhance antibiotic resistance, also among environmental strains. The analyzed data suggest the necessity of restriction and regular monitoring of antibiotics, which may be considered as environmental pollutants.

  10. Microwave power engineering applications

    CERN Document Server

    Okress, Ernest C

    2013-01-01

    Microwave Power Engineering, Volume 2: Applications introduces the electronics technology of microwave power and its applications. This technology emphasizes microwave electronics for direct power utilization and transmission purposes. This volume presents the accomplishments with respect to components, systems, and applications and their prevailing limitations in the light of knowledge of the microwave power technology. The applications discussed include the microwave heating and other processes of materials, which utilize the magnetron predominantly. Other applications include microwave ioni

  11. Role-Oriented Enterprise Systems

    DEFF Research Database (Denmark)

    Holst, Philip; Beringer, Joerg; Winther, Jacob

    This paper examines the concept of role-­oriented enterprise systems by investigating motivations for and approaches to constructing and reflecting predefined organizational roles in user interfaces of packaged enterprise systems. The research is conducted as case studies of Microsoft and SAP......, constructed from interviews, documents, and examples of role-­‐oriented enterprise system packages from both vendors. The research indicates that the primary motivation of the vendors for including predefined roles is to complement a function-­‐centric approach with a user-­‐centric approach to the design...... of user interfaces of enterprise systems. The research furthermore identifies strategies of an embedded and an independent approach to modeling the role concept and a unified and a componentized approach to reflecting role aggregation in user interfaces....

  12. Extracurricular activities of medical school applicants

    Directory of Open Access Journals (Sweden)

    Sang Hyun Kim

    2016-06-01

    Full Text Available Purpose: The purpose of this study was to investigate medical school applicants’ involvements in extracurricular activities including medical volunteering/community services, nonmedical community services, club activities, leadership role, and research. Methods: Extracurricular characteristics were compared for 448 applicants (223 males and 225 females who applied to Kangwon Medical School in 2013 to 2014. Frequency analysis, chi-square test, and simple correlation were conducted with the collected data. Results: The 448 applicants participated in medical volunteer/community services (15.3%, nonmedical community services (39.8%, club activities (22.9%, club officials (10%, and research (13.4%. On average, applicants from foreign universities participated in 0.9 medical volunteer/community service, 0.8 nonmedical community service, 1.7 club activities, and 0.6 research work. On the other hand, applicants from domestic universities reported 0.2 medical volunteer/community service, 1.0 nonmedical community service, 0.7 club activity, and 0.3 research. Conclusion: Involvement in extracurricular activities was extensive for medical school applicants. Participation in extracurricular activities differed between applicants from foreign and domestic universities. Females consistently reported greater participation in extracurricular activities than males. The data can be helpful for admission committees to recruit well-rounded applicants and compare between applicants with similar academic backgrounds.

  13. EUROPE: Swiss role

    International Nuclear Information System (INIS)

    Anon.

    1995-01-01

    On its continual round of CERN Member States, the European Committee for Future Accelerators (ECFA) met in Bern, Switzerland, in March. With CERN based in Geneva, and with a national research centre at the Paul Scherrer Institute (PSI), Villigen, Switzerland figures prominently in European particle physics. The Bern ECFA meeting provided a full picture of Swiss particle physics activities, project by project, and was prefaced by an overview by Claude Joseph of Lausanne. The number of experimental particle physicists in the country is about 200, with an academic staff of about 170. These are distributed among seven universities - Basel, Bern, Fribourg, Geneva, Lausanne, Neuchâtel and Zurich. In addition there are substantial research groups at ETH-Zurich and at PSI. Probably reflecting the proximity of CERN, the size of the national research community, when scaled to the population, is above the CERN Member State average. At CERN, there is a strong Swiss participation in research at the LEP electron-positron collider (concentrated on L3), with 44 physicists. There are also 33 physicists working at the LEAR low energy antiproton ring, in particular the Crystal Barrel and CP-LEAR studies. In addition there is interest in heavy ion research and in neutrino physics (NOMAD) as well as substantial participation in research and development work for experiments at the LHC. Away from CERN, there are 6 Swiss physicists working at the HERA electron-proton collider at DESY, Hamburg, with the national PSI programme involving about 40 physicists. (The PSI programme was covered at the Bern ECFA meeting by H.C. Walter.) Following the illustrious tradition of Fritz Zwicky, Switzerland also counts many astrophysicists. Theoretical physics, with a community of some 80 researchers, has a great tradition. Throughout the 20th century, leading Swiss research centres have been beacons of brilliance. Zurich, in particular, played a leading role, with Einstein, Schrödinger and Pauli among

  14. Immunologic roles of hyaluronan.

    Science.gov (United States)

    Mummert, Mark E

    2005-01-01

    Hyaluronan (HA), a large glycosaminoglycan composed of D-N-acetylglucosamine and D-glucuronic acid, is expressed in virtually all tissues and has long been considered to serve as a structural component or filling material in the tissue interstitium (Filler Theory). This idea was revised with the discovery of HA-binding proteins that introduced the concept that HA may also serve as an adhesive substrate for cellular trafficking (Adhesion Theory). Most recently, it has been shown that HA fragments can deliver maturational signals to dendritic cells (DCs) and high molecular weight HA polymers can deliver costimulatory signals to T-cells (Signaling Theory). Thus, HA may represent an important component of the immune system. Recently, we have evaluated the impact of HA on Langerhans cell (LC) maturation and migration using a novel peptide inhibitor of HA function, termed Pep-1 (GAHWQFNALTVR). As skin-specific members of the DC family, LCs are crucial for the initiation of cutaneous immune responses. Local injections of Pep-1 prevented hapten-induced LC migration from the epidermis, providing the first experimental evidence that HA facilitates their emigration. Moreover, Pep-1 also significantly inhibited the hapten-induced maturation of LCs in vivo as assessed by cell morphology, costimulatory molecule expression, and their ability to induce proliferation of allogeneic T-cells. HA therefore has dual functionality to facilitate LC migration and maturation, the two critical events for the initiation of adaptive immune responses. Finally, we have observed that DC-dependent, antigen-specific T-cell proliferation and cytokine secretion is blocked by Pep-1. These results have revealed a previously unrecognized role for HA in antigen presentation. Thus, far from an inert structural biopolymer, HA represents a multifunctional carbohydrate mediator of immune processes.

  15. Models and role models.

    Science.gov (United States)

    ten Cate, Jacob M

    2015-01-01

    Developing experimental models to understand dental caries has been the theme in our research group. Our first, the pH-cycling model, was developed to investigate the chemical reactions in enamel or dentine, which lead to dental caries. It aimed to leverage our understanding of the fluoride mode of action and was also utilized for the formulation of oral care products. In addition, we made use of intra-oral (in situ) models to study other features of the oral environment that drive the de/remineralization balance in individual patients. This model addressed basic questions, such as how enamel and dentine are affected by challenges in the oral cavity, as well as practical issues related to fluoride toothpaste efficacy. The observation that perhaps fluoride is not sufficiently potent to reduce dental caries in the present-day society triggered us to expand our knowledge in the bacterial aetiology of dental caries. For this we developed the Amsterdam Active Attachment biofilm model. Different from studies on planktonic ('single') bacteria, this biofilm model captures bacteria in a habitat similar to dental plaque. With data from the combination of these models, it should be possible to study separate processes which together may lead to dental caries. Also products and novel agents could be evaluated that interfere with either of the processes. Having these separate models in place, a suggestion is made to design computer models to encompass the available information. Models but also role models are of the utmost importance in bringing and guiding research and researchers. 2015 S. Karger AG, Basel

  16. Laser applications in neurosurgery

    Science.gov (United States)

    Cerullo, Leonard J.

    1985-09-01

    beam makes the laser superior to all conventional destructive instruments. 4)|The coagulative properties of certain chromophoric lasers has allowed a new attack on certain vascular tumors and malformations of the brain and spinal cord which had been operated only with trepidation or not at all. Early reports are sobering but encouraging. 5)|Finally, the use of the laser with tissue photosensitization, albeit it in its infancy, offers great promise. This is particularly true in the case of primary brain cancer, where the infiltration of tumorous tissue among normal pathways precludes the classical oncologic surgery practice of resection of a "safe margin". The ability to track and destroy these cells, without affecting adjacent cells, may be the greatest single contribution of the laser to neurosurgery in the future. The present applications of the laser are relatively crude by comparison with what is expected. Endoscopic laser surgery, both vascular and subarachnoid, will diminish morbidity and improve results. From the exotic treatment of aneurysms and arteriovenous malformations of the brain to the mundane care of herniated disks of the spine, it is anticipated that the laser will play an important role. The use of a laser, coupled with computerized imagining devices, will allow increasing precision in arrival to and treatment of deep seated lesions of the brain, brainstem, and spinal cord. The use of different wavelengths, perhaps in the X-ray and ultraviolet spectra, will allow increasing precision with decreasing invasion. Manipulation of wavelength, time, and treatment area will allow subcellular surgery, perhaps in the treatment of personality disorders and movement disorders as well as epilepsy. Tissue welding will allow heightened regenerative and recuperative powers to be exploited. The possibility of laser biostimulation must also be considered. In short, it appears that the future of the laser in neurosurgery is limited only by the imagination of the

  17. QUALITY PARAMETERS IN NANOTECHNOLOGIC APPLICATIONS

    Directory of Open Access Journals (Sweden)

    Ayşegül Akdoğan Eker

    2013-06-01

    Full Text Available Nanotechnology concept which has added a new dimension to our lives in recent years, is finding a place in every sector day by day. The combined effect of nanotechnology is almost equal to the industrial revolution of last 200 years and have is able to fill all developments in a few years. However this development should be taken under control. Otherwise unstoppable new structures will not ease life but will be a problem for humanity. For this purpose, the main parameters (from the start up stage of nano-technologic applications to the obtained product should be checked. These parameters are actually not different than the adaptation of the classical quality indicators for nanotechnology applications. Especially it plays an important role in obtaining a uniform distribution and regarding the features of the end product in nano-technological ceramic and etc. applications. The most important problem faced in particles of that size is the accumulation they create. Another problem is the increasing friction force as size gets smaller. The friction force of asubstance increases proportionally with the cube of its surface area. Another problem is surface tension. The increasing surface tension due to increasing surface area will cause the particles to attract and stick to each other. The structures aimed to be obtained are mostly complex and especially in upwards approach, it is thermodynamically very hard for the atoms to get into that order. Therefore in this announcement, we stated the quality parameters that will be taken into consideration in nano-technological applications and the methods for obtaining those parameters. The aim is to explain these parameters with all dimensions so that they will lead the way to the future nano-technological applications.

  18. The Perceived Social Roles of Mobile Phones in Travel

    DEFF Research Database (Denmark)

    Tussyadiah, Iis

    2012-01-01

    This study aims at measuring tourists’ perception towards the social characteristics of mobile devices and how they may lead to the perceived social role of mobile phones while traveling. Informed by social role theory and computing technology continuum of perspective (CP) model, the hypothesized...... relationships between mobile computing CP, respondents’ psychological traits, frequency of mobile phone use for travel, and perceived social role of mobile phones during traveling were tested. The results demonstrate that perceived intelligence and socialness of mobile phones prompt tourists to respond socially...... to mobile computing technology, thus emphasizing the importance of anthropomorphism in the designing of mobile technology for travel. As a managerial implication, smart mobile applications suggesting the roles of mobile devices as personal travel companions and/or assistants should be developed to increase...

  19. Gender, multiple roles, role meaning, and mental health.

    Science.gov (United States)

    Simon, R W

    1995-06-01

    This paper examines gender differences in the consequences of combining spouse, parent, and worker roles for mental health. I suggest that work and family roles have different meanings for males and females, and that differences in the meaning of these roles may be partially responsible for why the mental health advantages of holding multiple roles are fewer for women than for men. Based on qualitative analyses of follow-up, in-depth interviews with 40 employed married parents who participated in a community panel study of mental health, I find that sex differences in the perceived relationship between work and family roles may help account for sex differences in distress by contributing to male-female differences in both the extent and nature of work-parent conflicts, attributions of responsibility for marital problems, feelings of guilt, and self-evaluations as parents and spouses. By identifying gender differences in the meaning of roles among individuals who have the same multiple role configuration, and suggesting how these differences can help explain sex differences in well-being; this research may expand existing theories about the mental health consequences of multiple role involvements.

  20. Role Model, Hero or Champion? Children's Views Concerning Role Models

    Science.gov (United States)

    Bricheno, Patricia; Thornton, Mary

    2007-01-01

    Background: Claims that male role models can improve the behaviour and achievement of boys are familiar and persistent. However, research has not confirmed such a link; recent UK studies indicate that peers and relatives may be far more important to boys than their teachers. Given the seemingly relentless reference to male teachers as role models…

  1. The human role in space. Volume 3: Generalizations on human roles in space

    Science.gov (United States)

    1984-01-01

    The human role in space was studied. The role and the degree of direct involvement of humans that will be required in future space missions, was investigated. Valid criteria for allocating functional activities between humans and machines were established. The technology requirements, ecnomics, and benefits of the human presence in space were examined. Factors which affect crew productivity include: internal architecture; crew support; crew activities; LVA systems; IVA/EVA interfaces; and remote systems management. The accomplished work is reported and the data and analyses from which the study results are derived are included. The results provide information and guidelines to enable NASA program managers and decision makers to establish, early in the design process, the most cost effective design approach for future space programs, through the optimal application of unique human skills and capabilities in space.

  2. Radon applications in geosciences - Progress & perspectives

    Science.gov (United States)

    Barbosa, S. M.; Donner, R. V.; Steinitz, G.

    2015-05-01

    During the last decades, the radioactive noble gas radon has found a variety of geoscientific applications, ranging from its utilization as a potential earthquake precursor and proxy of tectonic stress over its specific role in volcanic environments to a wide range of applications as a tracer in marine and hydrological settings. This topical issue summarizes the current state of research as exemplified by some original research articles covering the aforementioned as well as other closely related aspects and points to some important future directions of radon application in geosciences. This editorial provides a more detailed overview of the contents of this volume, a brief summary of the rationale underlying the diverse applications, and outlines some important perspectives.

  3. The Role(s) of Process Models in Design Practice

    DEFF Research Database (Denmark)

    Iversen, Søren; Jensen, Mads Kunø Nyegaard; Vistisen, Peter

    2018-01-01

    This paper investigates how design process models are implemented and used in design-driven organisations. The archetypical theoretical framing of process models, describe their primary role as guiding the design process, and assign roles and deliverables throughout the process. We hypothesise...... that the process models also take more communicative roles in practice, both in terms of creating an internal design rationale, as well as demystifying the black box of design thinking to external stakeholders. We investigate this hypothesis through an interview study of four major danish design......-driven organisations, and analyse the different roles their archetypical process models take in their organisations. The main contribution is the identification of three, often overlapping roles, which design process models showed to assume in design-driven organisations: process guidance, adding transparency...

  4. Roles of Communication Problems and Communication Strategies on Resident-Related Role Demand and Role Satisfaction.

    Science.gov (United States)

    Savundranayagam, Marie Y; Lee, Christopher

    2017-03-01

    This study investigated the impact of dementia-related communication difficulties and communication strategies used by staff on resident-related indicators of role demand and role satisfaction. Formal/paid long-term care staff caregivers (N = 109) of residents with dementia completed questionnaires on dementia-related communication difficulties, communication strategies, role demand (ie, residents make unreasonable demands), and role satisfaction (measured by relationship closeness and influence over residents). Three types of communication strategies were included: (a) effective repair strategies, (b) completing actions by oneself, and (c) tuning out or ignoring the resident. Analyses using structural equation modeling revealed that communication problems were positively linked with role demand. Repair strategies were positively linked with relationship closeness and influence over residents. Completing actions by oneself was positively linked to role demand and influence over residents, whereas tuning out was negatively linked with influence over residents. The findings underscore that effective caregiver communication skills are essential in enhancing staff-resident relationships.

  5. Testing the Claims of Asylum Seekers: The Role of Language Analysis

    Science.gov (United States)

    Eades, Diana

    2009-01-01

    Language tests in immigration contexts typically perform a gate-keeping role in decisions about whether an applicant should be granted residence or citizenship in a new country. In refugee contexts, so-called language tests or language analyses also play a gate-keeping role, but a more ambitious one; namely that of providing answers to questions…

  6. Combining Linked Data and knowledge engineering best practices to design a lightweight role ontology

    NARCIS (Netherlands)

    Passant, A; Isaac, A.H.J.C.A.; Laublet, P

    2011-01-01

    Defining roles of agents (i.e., people, organisations, etc.) is required in various Semantic Web applications, including access control, knowledge management and skill repository. So far, many theoretical discussions have taken place on the nature of roles and how to represent them. In this paper,

  7. Perceptions of Challenge: The Role of Catastrophe Theory in Piano Learning

    Science.gov (United States)

    Bugos, Jennifer; Lee, William

    2015-01-01

    The purpose of this study is to evaluate the perceptions of private piano instructors on the role of challenge in teaching and learning the piano and to examine the potential application of catastrophe theory in understanding the role and outcomes of such challenges. A 23-item electronic questionnaire was administered to collect quantitative and…

  8. 10 CFR 2.1316 - Authority and role of NRC staff.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Authority and role of NRC staff. 2.1316 Section 2.1316... ORDERS Procedures for Hearings on License Transfer Applications § 2.1316 Authority and role of NRC staff. (a) During the pendency of any hearing under this subpart, consistent with the NRC staff's findings...

  9. The Java EE architect's handbook how to be a successful application architect for Java EE applications

    CERN Document Server

    Ashmore, Derek C.

    2014-01-01

    This handbook is a concise guide to assuming the role of application architect for Java EE applications. This handbook will guide the application architect through the entire Java EE project including identifying business requirements, performing use-case analysis, object and data modeling, and guiding a development team during construction. This handbook will provide tips and techniques for communicating with project managers and management. This handbook will provide strategies for making your application easier and less costly to support. Whether you are about to architect your first Java EE application or are looking for ways to keep your projects on-time and on-budget, you will refer to this handbook again and again.

  10. The role of advanced sensing in smart cities.

    Science.gov (United States)

    Hancke, Gerhard P; Silva, Bruno de Carvalho E; Hancke, Gerhard P

    2012-12-27

    In a world where resources are scarce and urban areas consume the vast majority of these resources, it is vital to make cities greener and more sustainable. Advanced systems to improve and automate processes within a city will play a leading role in smart cities. From smart design of buildings, which capture rain water for later use, to intelligent control systems, which can monitor infrastructures autonomously, the possible improvements enabled by sensing technologies are immense. Ubiquitous sensing poses numerous challenges, which are of a technological or social nature. This paper presents an overview of the state of the art with regards to sensing in smart cities. Topics include sensing applications in smart cities, sensing platforms and technical challenges associated with these technologies. In an effort to provide a holistic view of how sensing technologies play a role in smart cities, a range of applications and technical challenges associated with these applications are discussed. As some of these applications and technologies belong to different disciplines, the material presented in this paper attempts to bridge these to provide a broad overview, which can be of help to researchers and developers in understanding how advanced sensing can play a role in smart cities.

  11. Balancing the Roles of a Family Medicine Residency Faculty: A Grounded Theory Study.

    Science.gov (United States)

    Reitz, Randall; Sudano, Laura; Siler, Anne; Trimble, Kristopher

    2016-05-01

    Great variety exists in the roles that family medicine residency faculty fill in the lives of their residents. A family medicine-specific model has never been created to describe and promote effective training relationships. This research aims to create a consensus model for faculty development, ethics education, and policy creation. Using a modified grounded theory methods, researchers conducted phone interviews with 22 key informants from US family medicine residencies. Data were analyzed to delineate faculty roles, common role conflicts, and ethical principles for avoiding and managing role conflicts. Key informants were asked to apply their experience and preferences to adapt an existing model to fit with family medicine residency settings. The primary result of this research is the creation of a family medicine-specific model that describes faculty roles and provides insight into how to manage role conflicts with residents. Primary faculty roles include Role Model, Advisor, Teacher, Supervisor, and Evaluator. Secondary faculty roles include Friendly Colleague, Wellness Supporter, and Helping Hand. The secondary roles exist on a continuum from disengaged to enmeshed. When not balanced, the secondary roles can detract from the primary roles. Differences were found between role expectations of physician versus behavioral science faculty and larger/university/urban residencies versus smaller/community/rural residencies. Diversity of opinion exists related to the types of roles that are appropriate for family medicine faculty to maintain with residents. This new model is a first attempt to build consensus in the field and has application to faculty development, ethics education, and policy creation.

  12. Downhole Applications of Magnetic Sensors.

    Science.gov (United States)

    Gooneratne, Chinthaka P; Li, Bodong; Moellendick, Timothy E

    2017-10-19

    In this paper we present a review of the application of two types of magnetic sensors-fluxgate magnetometers and nuclear magnetic resonance (NMR) sensors-in the oil/gas industry. These magnetic sensors play a critical role in drilling wells safely, accurately and efficiently into a target reservoir zone by providing directional data of the well and acquiring information about the surrounding geological formations. Research into magnetic sensors for oil/gas drilling has not been explored by researchers to the same extent as other applications, such as biomedical, magnetic storage and automotive/aerospace applications. Therefore, this paper aims to serve as an opportunity for researchers to truly understand how magnetic sensors can be used in a downhole environment and to provide fertile ground for research and development in this area. A look ahead, discussing other magnetic sensor technologies that can potentially be used in the oil/gas industry is presented, and what is still needed in order deploy them in the field is also addressed.

  13. Downhole Applications of Magnetic Sensors

    Directory of Open Access Journals (Sweden)

    Chinthaka P. Gooneratne

    2017-10-01

    Full Text Available In this paper we present a review of the application of two types of magnetic sensors—fluxgate magnetometers and nuclear magnetic resonance (NMR sensors—in the oil/gas industry. These magnetic sensors play a critical role in drilling wells safely, accurately and efficiently into a target reservoir zone by providing directional data of the well and acquiring information about the surrounding geological formations. Research into magnetic sensors for oil/gas drilling has not been explored by researchers to the same extent as other applications, such as biomedical, magnetic storage and automotive/aerospace applications. Therefore, this paper aims to serve as an opportunity for researchers to truly understand how magnetic sensors can be used in a downhole environment and to provide fertile ground for research and development in this area. A look ahead, discussing other magnetic sensor technologies that can potentially be used in the oil/gas industry is presented, and what is still needed in order deploy them in the field is also addressed.

  14. Phytosanitary irradiation - Development and application

    Science.gov (United States)

    Hallman, Guy J.; Loaharanu, Paisan

    2016-12-01

    Phytosanitary irradiation, the use of ionizing radiation to disinfest traded agricultural commodities of regulated pests, is a growing use of food irradiation that has great continued potential for increase in commercial application. In 2015 approximately 25,000 t of fresh fruits and vegetables were irradiated globally for phytosanitary purposes. Phytosanitary irradiation has resulted in a paradigm shift in phytosanitation in that the final burden of proof of efficacy of the treatment has shifted from no live pests upon inspection at a port of entry (as for all previous phytosanitary treatments) to total dependence on certification that the treatment for target pests is based on adequate science and is commercially conducted and protected from post-treatment infestation. In this regard phytosanitary irradiation is managed more like a hazard analysis and critical control point (HACCP) approach more consistent with food safety than phytosanitation. Thus, phytosanitary irradiation offers a more complete and rigorous methodology for safeguarding than other phytosanitary measures. The role of different organizations in achieving commercial application of phytosanitary irradiation is discussed as well as future issues and applications, including new generic doses.

  15. Role of Melanin in Oncogenesis

    Science.gov (United States)

    2011-08-01

    and validating the role of melanin in human melanoma pathobiology. Conclusions  Chronic production of excess melanin caused unique gene...vitro effects in a small sample size.  A long-term study with animal models and human patient specimens is needed to determine if excess melanin ...AD_________________ Award Number: W81XWH-10-1-0066 TITLE: Role of Melanin in Oncogenesis

  16. Metrology's role in quality assurance

    International Nuclear Information System (INIS)

    Zeederberg, L.B.

    1982-01-01

    Metrology, the science of measurement, is playing an increasing role in modern industry as part of an on-going quality assurance programme. At Escom, quality assurance was critical during the construction of the Koeberg nuclear facility, and also a function in controlling services provided by Escom. This article deals with the role metrology plays in quality assurance

  17. Life Role Salience and Values

    NARCIS (Netherlands)

    van Hattem, A.H.; Ossenkop, C.; Dikkers, J.S.E.; Vinkenburg, C.J.

    2013-01-01

    Purpose-Even though both values and life roles are intensively studied topics, limited research has been conducted regarding the association between the two. In the context of the Dutch public sector, this study therefore examines how life roles and values relate to each other. Moreover, the

  18. Role model and prototype matching

    DEFF Research Database (Denmark)

    Lykkegaard, Eva; Ulriksen, Lars

    2016-01-01

    ’ meetings with the role models affected their thoughts concerning STEM students and attending university. The regular self-to-prototype matching process was shown in real-life role-models meetings to be extended to a more complex three-way matching process between students’ self-perceptions, prototype...

  19. Development of the Role Scenario of the Personnel Management Specialist Activity

    OpenAIRE

    Stolyaruk Khrystyna S.

    2013-01-01

    The article is devoted of the issues of development of classification and content of role, which are performed by personnel management specialists in their professional activity. It proves a necessity of development of role scenarios under conditions of application of the competence approach in training and practical activity. Thus, the author offers five key roles in activity of a personnel management specialist, which reflect different vectors of directions of the scenario of professional a...

  20. Framework for Evaluating the Impact of Advanced Practice Nursing Roles.

    Science.gov (United States)

    Bryant-Lukosius, Denise; Spichiger, Elisabeth; Martin, Jacqueline; Stoll, Hansruedi; Kellerhals, Sabine Degen; Fliedner, Monica; Grossmann, Florian; Henry, Morag; Herrmann, Luzia; Koller, Antje; Schwendimann, René; Ulrich, Anja; Weibel, Lukas; Callens, Betty; De Geest, Sabina

    2016-03-01

    To address the gap in evidence-based information required to support the development of advanced practice nursing (APN) roles in Switzerland, stakeholders identified the need for guidance to generate strategic evaluation data. This article describes an evaluation framework developed to inform decisions about the effective utilization of APN roles across the country. A participatory approach was used by an international group of stakeholders. Published literature and an evidenced-based framework for introducing APN roles were analyzed and applied to define the purpose, target audiences, and essential elements of the evaluation framework. Through subsequent meetings and review by an expert panel, the framework was developed and refined. A framework to evaluate different types of APN roles as they evolve to meet dynamic population health, practice setting, and health system needs was created. It includes a matrix of key concepts to guide evaluations across three stages of APN role development: introduction, implementation, and long-term sustainability. For each stage, evaluation objectives and questions examining APN role structures, processes, and outcomes from different perspectives (e.g., patients, providers, managers, policy-makers) were identified. A practical, robust framework based on well-established evaluation concepts and current understanding of APN roles can be used to conduct systematic evaluations. The evaluation framework is sufficiently generic to allow application in developed countries globally, both for evaluation as well as research purposes. © 2016 Sigma Theta Tau International.

  1. The role of mental health professionals in political asylum processing.

    Science.gov (United States)

    Meffert, Susan M; Musalo, Karen; McNiel, Dale E; Binder, Renée L

    2010-01-01

    Applying for asylum in the United States can be a strenuous process for both applicants and immigration attorneys. Mental health professionals with expertise in asylum law and refugee trauma can make important contributions to such cases. Not only can mental health professionals provide diagnostic information that may support applicants' claims, but they can evaluate how culture and mental health symptoms relate to perceived deficits in credibility or delays in asylum application. They can define mental health treatment needs and estimate the possible effects of repatriation on mental health. Mental health professionals can also provide supportive functions for clients as they prepare for testimony. Finally, in a consultative role, mental health experts can help immigration attorneys to improve their ability to elicit trauma narratives from asylum applicants safely and efficiently and to enhance their resilience in response to vicarious trauma and burnout symptoms arising from work with asylum seekers.

  2. NASDA'S activities and roles in promoting satellite utilization experiments

    Science.gov (United States)

    Shigeta, Tsutomu; Miyoshi, Takashi

    2004-02-01

    While NASDA has been engaged in the development of new satellite missions and the bus technologies, NASDA explores new and attractive applications by promoting the utilization of satellite missions and strengthening the relationships with external parties. Offering opportunities to external parties for conducting application experiments will bring great chances for them in challenging and experimenting new space-based applications. Consequently, it is expected that the outcomes of the space development are returned to general public, research institutes, industries, and that ideas or requirements for new satellite mission could emerge and be materialized. With these objectives in mind, NASDA is presently planning a new space project that is named "i-Space". The i-Space project aims to contribute to the progressing "IT Revolution" by providing new space communication capabilities and to develop practical applications by collaborating with external parties. This paper introduces the activities and roles of NASDA in promoting satellite utilization experiments, particularly focusing on the i-Space project.

  3. Analysis of the Chemical, Pharmacological and Clinical Applications of Polygonum Cuspidatum

    Science.gov (United States)

    Guo, Chenyang; Bai, Ming; Miao, Mingsan; Miao, Yanyan

    2018-01-01

    Traditional Chinese medicine Polygonum cuspidatum widely used, the larger production, and in the clinical application of more, but the role played by the role of different roles are also different. By reviewing the relevant literatures in recent years, the chemical constituents and pharmacological effects of Polygonum cuspidatum were sorted and summarized, and the role of Polygonum cuspidatum was analyzed, and the function of Polygonum cuspidatum was explored to find out the role of Polygonum cuspidatum in compatibility. Application law. Which can not only study the medicinal mechanism of Polygonum cuspidatum, but also provide the theoretical basis for the medicinal development, clinical treatment and comprehensive utilization of Polygonum cuspidatum.

  4. Role clarity and role conflict among Swedish diabetes specialist nurses.

    Science.gov (United States)

    Boström, Eva; Hörnsten, Asa; Lundman, Berit; Stenlund, Hans; Isaksson, Ulf

    2013-10-01

    To explore diabetes specialist nurses (DSNs)' perceptions of their role in terms of clarity, conflict and other psychosocial work aspects. A cross-sectional study was conducted among DSNs in a county in northern Sweden. The DSNs answered the Nordic Questionnaire of Psychological and Social Factors at Work (QPS Nordic) about psychosocial aspects of their work. Statistical analysis compared DSNs with a reference group of different health professionals. Correlations between role clarity, role conflict, and other variables were analysed. The DSNs perceived more, and higher, job demands, including quantitative, decision-making and learning demands, but also more positive challenges at work compared with the reference group. Role clarity correlated with experiences of health promotion, perception of mastery, co-worker support, and empowering leadership, while role conflict correlated with quantitative and learning demands. The DSNs perceived high demands but also positive challenges in their work. Their role expectations correlated with several psychosocial work aspects. It is important that DSNs should be presented with positive challenges as meaningful incentives for further role development and enhanced mastery of their work. Copyright © 2013 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  5. Therapeutic efficiency of synthokine SC-55494, a human IL-3 receptor agonist, in a nonhuman primate model of HIGH dose, sublethal, radiation-induced marrow aplasia; Efficacite therapeutique d`un variant d`interleukine-3 chez des macaques irradies

    Energy Technology Data Exchange (ETDEWEB)

    Herodin, F.; Farese, A.; Grab, L.; McKearn, J.P.; Mestries, J.C.; McVittie, T.J.

    1994-12-31

    The synthetic cytokine (Synthokine) SC-55494 is a high affinity IL-3 receptor ligand. The therapeutic administration of Synthokine to total body irradiated (TBI) monkeys (7 Gy gamma) from day 1 post TBI for 23 days, significantly enhanced platelet recovery and modulated aneutrophil nadir. (author). 6 refs.

  6. Histologic assessment of treatment effect of preoperative chemo-radiation in patients presenting with resectable pancreatic adenocarcinoma; Chimioradiotherapie preoperatoire des adenocarcinomes du pancreas: evaluation anatomopathologique de l'efficacite therapeutique

    Energy Technology Data Exchange (ETDEWEB)

    Le Scodan, R. [Departement de radiotherapie, centre Rene-Huguenin, 35, rue Dailly, 92210 Saint-Cloud (France); Mornex, F. [Departement de radiotherapie-oncologie, centre hospitalier Lyon-Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France); Partensky, C. [Service de chirurgie digestive, hopital edouard-Herriot, 5, place Arsonval, 69003 Lyon (France); Mercier, C. [Departement de statistiques medicales, centre hospitalier Lyon-Sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Benite cedex (France); Valette, P.J. [Service de radiologie digestive, hopital edouard-Herriot, 5, place Arsonval, 69003 Lyon (France); Ychou, M. [Departement d' oncologie medicale, centre Val-d' Aurelle-Paul-Lamarque, 208, rue des Apothicaires, 34298 Montpellier cedex 5 (France); Bibeau, F. [Departement de pathologie, centre Val-d' Aurelle-Paul-Lamarque, 208, rue des Apothicaires, 34298 Montpellier cedex 5 (France); Scoazec, J.Y. [Laboratoire d' anatomie et de cytologie pathologiques, hopital edouard-Herriot, 5, place Arsonval, 69003 Lyon (France)

    2011-04-15

    Purpose. - Several phase II studies have shown the feasibility of neo-adjuvant chemo-radiation regimens for resectable localized pancreatic adenocarcinoma. However, there is to date no completed phase III study to validate this approach and treatment effects evaluation still remains an active area of investigation. From the mature results of the SFRO-FFCD 9704 trial, we explored the anti-tumoral effect of a 5-fluoro-uracil and cisplatin-based preoperative chemo-radiation regimen, with a special highlight on the histopathological response and performed a literature review. Patients and methods. - Treatment consisted of concurrent radiotherapy (50 Gy within five weeks) and chemotherapy with 5-fluoro-uracil (300 mg/m{sup 2}/day, five days/week, weeks 1-5) and cisplatin (20 mg/m{sup 2}/day, days 1-5 and 29-33), followed by surgical resection of the pancreatic tumour in patients without progression. Results. - In all, 41 patients were enrolled, 26 patients (63%) underwent surgical resection with curative intent and 21 (80.7%) had R0 resection. A total of 13 of 26 specimens (50%) presented a major pathologic response (=80% of severely degenerative cancer cells), with one complete pathologic response. The local recurrence and two-year survival rates were 4 and 32%, respectively, for the 26 operated patients. Conclusion. - Our results suggest that preoperative chemo-radiation provides anti-tumoral effect associated with major histopathological response in 50% of patients and a high R0 resection rate. Evaluation of histopathological response to neo-adjuvant chemo-radiation may serve as a surrogate marker for treatment efficacy and further research is needed to determine new prognostic and predictive factors of treatment response. (authors)

  7. A prospective study of the early clinical symptoms following a 2 Gy therapeutic whole-body irradiation; Etude prospective de la symptomatologie clinique precoce apres irradiation corporelle totale therapeutique de 2 Gy

    Energy Technology Data Exchange (ETDEWEB)

    Fizazi, K.; Chaillet, M.P.; Fourquet, A.; Jammet, P.; Cosset, J.M. [Institut Curie, 75 - Paris (France)

    1995-10-01

    Early human tolerance following total body irradiation (TBI) according to the dose received is still poorly known. Thirteen selected patients were prospectively evaluated for clinical side effects during the first 10 hours following a 2 Gy TBI prior to bone marrow transplantation. All of them but one were treated for haematological malignancies and were in clinical remission at the date of TBI. There were 10 males and 3 females, with a median age of 43 y (range 16*61) and a good performance status (WHO 0-1). They received granisetron (3 mg) injected intravenously 1 h before the time of TBI in order to prevent nausea and vomiting. The main symptoms consisted in drowsiness (69%), headache (62%), xerostomia (62%), nausea and vomiting (46%), anorexia (38%), parotid gland pain (23%) and abdominal pain (8%). Their intensity was always moderate, except for 2 patients who experimented severe vomiting. The incidence rate and the time-course of the symptoms of the prodromal phase may proved to be helpful for early clinical evaluation and triage of victims of an accidental irradiation. In particular, absence of fever at the 6{sup th} h after TBI supports the assumption of an estimated exposure dose below 2 Gy. (authors). 23 refs., 2 tabs.

  8. Detection and characterisation of trypanosome strains supposedly resistant to trypanocidal drugs in Senegal; Detection au buffy coat technique et en ELISA de souches de trypanosomes supposees chimioresistantes au Senegal et caracterisation therapeutique

    Energy Technology Data Exchange (ETDEWEB)

    Diaite, A; Seye, M; Mane, A; Ndiaye, T; Seye, M M [Institut Senegalais de Recherches Agricoles (ISRA), Dakar (Senegal). Lab. de Parasitologie

    1997-02-01

    In the region of Sokone cattle are constantly exposed to infections with trypanosomes transmitted by Glossina morsitans submorsitans and G. palpalis gambiensis. Trypanocidal drugs are widely used by the farmers on the 50,000 cattle present in the region. Consequently, drug resistance has become a major problem. During the present study goats were inoculated with trypanosome strains isolated from infected cattle. Following the appearance of parasitaemia, the animals were treated with either Berenil, Samorin or Ethidium. The results indicated the parasites were susceptible to Samorin, but one of the Trypanosoma vivax strains showed resistance to Berenil and Ethidium. In addition, the performance of the antigen detection ELISA was compared with that of the Buffy Coat Technique using more than 1000 serum samples from the Sokone region and 100 samples from Northern Senegal infested with tsetse flies. The results showed a very high specificity of 98%. However, additional tests will be necessary to assess the sensitivity properly. (author). 3 refs, 7 tabs.

  9. What is the future of the children after therapeutic irradiation of their mother during their pregnancy?; Que deviennent les enfants dont les meres ont ete irradiees a visee therapeutique pendant leur grossesse?

    Energy Technology Data Exchange (ETDEWEB)

    Anon

    2008-12-15

    Abnormalities in children exposed to radiation during gestation occur more specially when the mother irradiation is made between the third and the eleventh week of pregnancy. However a case is reported through a child irradiated in utero and whom development is normal. So, more than a proposition of abortion to the parents it would be convenient to propose a long term surveillance by pediatricians and register these cases in a national data base, this rounding up of knowledge will allow to consolidate the advices that could be given to the parents on taking any precaution in this particularly difficult context. (N.C.)

  10. Radioprotection after therapeutic injection of [{sup 131}I]-mibg: Prerequisite to the MIITOP protocol opening; Radioprotection apres injection therapeutique de [131I]-mIBG: donnees prealables a l'ouverture du protocole MIITOP-0607

    Energy Technology Data Exchange (ETDEWEB)

    Petyt, G.; Cougnenc, O.; Carpentier, P. [Centre Oscar-Lambret, CLCC Nord-Pas-de-Calais, Dept. de Medecine Nucleaire, 59 - Lille (France); Defachelles, A.S. [Centre Oscar-Lambret, Dept. d' Oncologie Pediatrique, 59 - Lille (France); Cazin, J.L. [Centre Oscar-Lambret, Dept. de Pharmacie Clinique, 59 - Lille (France)

    2009-12-15

    Introduction The MIITOP-0607 protocol, studying the efficiency of administration of topotecan and myelo-suppressive [{sup 131}I]-mibg therapy in children affected by neuroblastoma, needed to assess irradiation risks on staff and family of children to obtain the agreement of the Autorite de surete nucleaire (A.S.N.). Our aim was to quantify irradiation of the staff during preparation of the mibg and to assay the irradiation and contamination of the accompanying persons. Patient and methods Radiation exposure of the staff was measured during the preparation, transport and administration of the first treatment. Salivary and urinary excretions were monitored well as the atmospheric radioactivity. Radiation exposure and contamination of the accompanying persons were also measured. Results Finger dose of 3 mSv and whole body dose of 50 {mu}Sv were estimated for preparation of an 11.1 GBq syringe. Irradiation from urinary activity can be as low as 100 {mu}Sv if a dedicated device is used. Salivary excretion decreased rapidly during the first 24 hours. Atmospheric contamination always remained below 25 Bq m-3. Total irradiation of the accompanying persons is about 2.35 mSv for the two consecutive injections (9,3 and 11,1 GBq). Internal contamination occurred only once and corresponded to a 27 {mu}Sv whole body irradiation and 670 {mu}Sv thyroid irradiation. Conclusion This study shows the safety of [{sup 131}I]-mibg treatments using high activities. The involved dose is not negligible but seems to be acceptable in the specific paediatric oncology context if radioprotection instructions are met and if optimization of protocols is performed. (authors)

  11. To understand and manage the digestive radiation injuries: importance of the mucous reaction and new therapy orientations; Apprehender et gerer les lesions radiques digestives: importance de la reaction muqueuse et nouvelles orientations therapeutiques

    Energy Technology Data Exchange (ETDEWEB)

    Francois, A

    2007-09-15

    Actually the radiotherapy that concerns 50% of anti tumoral treatments is accompanied by side effects. The evolution of this therapy turns towards the limitation of the early effects but also the delayed effects in order to improve the quality of life of patients. The first answer was to reduce the radiation doses and the irradiated volume. Three directions are to be kept in mind concerning the digestive tissues: Fight against the break of the epithelial homeostasis by increasing the pool of cells before irradiation and by facilitating the processes of restoration and epithelial regeneration by the stimulation of the proliferation of the cells of progenitor compartments; Fight against the phenotype changes of the cells, and more globally against the cellular activation and its consequences: activation of the vascular endothelium and the initiation of the inflammatory and thrombosis processes; activation of the vascular smooth muscular cells and stenosis; oxidative stress and tissue hypoxia; recruitment and activation of the mesenchyme cells and matrix unbalance; to consider the global nature of the secondary effects, and become aware that there is, besides the physical twilight connected to the irradiation configuration, a biological twilight, that is to say a potential repercussion of the irradiation effects out of the field, on the global nature of an organ even an organism, and this in the therapy and accident configurations. (N.C.)

  12. Medullary aplasia secondary to an irradiation accident: Treatment options and evolution of the concepts; L'aplasie medullaire secondaire a un accident d'irradiation : options therapeutiques et evolution des concepts

    Energy Technology Data Exchange (ETDEWEB)

    De Revel, T. [Service d' Hematologie, HIA Percy, et Service de Neurovirologie, Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France); Fagot, T.; Souleau, B. [Service d' Hematologie, HIA Percy, Clamart (France); Dormont, D. [Service de Neurovirologie, Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France); Nedellec, G. [Service d' Hematologie, HIA Percy, Clamart (France)

    2002-07-01

    Bone marrow grafting following accidental irradiation exposure should be viewed in the perspective of a severe myeloablative syndrome linked to high medullary damage for a dose range higher than 6-8 Gy, resulting in very late or no recovery. Prognosis will depend on the presence or absence of radio-combined injuries, the toxicity of the transplant procedure, and the risk of rejection induced by insufficient percritical immunosuppression. It is in this context that new cell therapy modalities, which combine enhanced peripheral hematopoietic cell engraftment and high immunosuppressive conditioning regimen with low extrahematological toxicity, inducing early and stable mixed lymphomyeloid chimerism with minimal morbidity, can be considered. Such an approach is being evaluated in the treatment of patients with hematological malignancies at high risk of transplant-related mortality using conventional bone marrow methods. (author)

  13. Pediatric nasopharyngeal carcinoma: Anatomo-clinic aspects, therapeutic results and progressive particularities;Le cancer du cavum de l'enfant et l'adulte jeune: aspects anatomocliniques, therapeutiques et particularites evolutives

    Energy Technology Data Exchange (ETDEWEB)

    Frikha, M.; Toumi, N. [Service de carcinologie medicale, CHU Habib-Bourguiba, Sfax (Tunisia); Ghorbel, L.; Ben Salah, H.; Daoud, J. [Service de carcinologie radiotherapie, CHU Habib-Bourguiba, Sfax, (Tunisia); Khabir, A.; Boudawara, T. [Service d' anatomopathologie, CHU Habib-Bourguiba, Sfax (Tunisia); Karray, H. [Service de virologie, CHU Habib-Bourguiba, Sfax (Tunisia); Gargouri, R. [Centre de biotechnologie, Sfax (Tunisia); Ghorbel, A. [Service d' ORL, CHU Habib-Bourguiba, Sfax (Tunisia)

    2010-06-15

    Purpose We retrospectively analyzed anatomo-clinic, therapeutic and progressive particularities of 74 young patients (= 20 years) with nasopharyngeal carcinoma treated between 1993 and 2005. Patients and methods Initial work-up included a fiberoptic naso-fiberscopy with biopsy, computed tomography and/or MRI of nasopharynx and neck, chest X-ray, abdominal ultrasonography and bone scan. Patients were treated with either primary chemotherapy (epirubicin and cisplatin) followed by radiotherapy or concomitant radio chemotherapy (five fluorouracil and cisplatin). Radiotherapy was delivered to a total dose of 70 to 75 Gy to nasopharynx and involved cervical lymph nodes and 50 Gy to the remainder cervical areas. Results The median age was 16 years. Sixty-three percent of patients had undifferentiated tumors. Sixty-six percent had locally advanced tumor. With a median follow-up of 107 months, one patient presented a local relapse, 24 patients developed distant metastases with a median delay of 7 months. The 5 years overall survival and disease-free survival were 66 and 65 %. Late complications were dominated by dry mouth and endocrine disorders. Comments Pediatric nasopharyngeal carcinoma is characterized by an early metastatic diffusion. Local control is excellent but with severe late toxicities. New techniques of radiotherapy and new molecules of chemotherapy could improve these results. (authors)

  14. Is there a Greater Role for Prime Numbers in our Schools?

    Science.gov (United States)

    Cairns, Grant

    2005-01-01

    Prime numbers play an extremely important role in modern mathematics. Apart from still being the object of intense research activity, their applications in banking and security underline a key phenomenon: in the modern world, useful applications of mathematics often come from very "pure" abstract theories. Curiously, despite their undeniable…

  15. Inorganic biomaterials structure, properties and applications

    CERN Document Server

    Zhang, Xiang C

    2014-01-01

    This book provides a practical guide to the use and applications of inorganic biomaterials. It begins by introducing the concept of inorganic biomaterials, which includes bioceramics and bioglass. This concept is further extended to hybrid biomaterials consisting of inorganic and organic materials to mimic natural biomaterials. The book goes on to provide the reader with information on biocompatibility, bioactivity and bioresorbability. The concept of the latter is important because of the increasing role resorbable biomaterials are playing in implant applications. The book also introduces a n

  16. CCD research. [design, fabrication, and applications

    Science.gov (United States)

    Gassaway, J. D.

    1976-01-01

    The fundamental problems encountered in designing, fabricating, and applying CCD's are reviewed. Investigations are described and results and conclusions are given for the following: (1) the development of design analyses employing computer aided techniques and their application to the design of a grapped structure; (2) the role of CCD's in applications to electronic functions, in particular, signal processing; (3) extending the CCD to silicon films on sapphire (SOS); and (4) all aluminum transfer structure with low noise input-output circuits. Related work on CCD imaging devices is summarized.

  17. CYCLODEXTRINS - FIELFS OF APPLICATION. PART II

    Directory of Open Access Journals (Sweden)

    Gh. Duca

    2012-12-01

    Full Text Available This paper represents an analysis of potential and current applications of cyclodextrins as biologically active substances in medicine. The main applications described here include use of cyclodextrins as agents that form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol, agents that form inclusion complexes with exogenous substances with their man role as guest molecules (sugammadex, FBCx, agents that block endogenous and exogenous macromolecules (ion channels, anthrax toxin, α-hemolysin, and agents which activity is based on the chemical nature of them and of their derivatives (cyclodextrin polysulphate derivatives. The fi rst classifi cation for medically important biological activity of cyclodextrins has been proposed.

  18. Magnetic nanoparticles for application in cancer therapy

    Energy Technology Data Exchange (ETDEWEB)

    Rivas, J. [Department of Applied Physics, University of Santiago de Compostela, E-15782 Santiago de Compostela (Spain); Banobre-Lopez, M. [Department of Physical Chemistry, University of Santiago de Compostela, E-15782 Santiago de Compostela (Spain); Pineiro-Redondo, Y. [Department of Applied Physics, University of Santiago de Compostela, E-15782 Santiago de Compostela (Spain); Rivas, B., E-mail: jose.rivas@usc.es [Department of Operative Dentistry and Endodontics, University of Santiago de Compostela, E-15782 Santiago de Compostela (Spain); Lopez-Quintela, M.A. [Department of Physical Chemistry, University of Santiago de Compostela, E-15782 Santiago de Compostela (Spain)

    2012-10-15

    Magnetic particles play nowadays an important role in different technological areas with potential applications in fields such as electronics, energy and biomedicine. In this report we will focus on the hyperthermia properties of magnetite nanoparticles and the effect of several chemical/physical parameters on their heating properties. We will discuss about the need of searching new smaller magnetic systems in order to fulfill the required physical properties which allow treating tumoral tissues more efficiently by means of magnetically induced heat. Preliminary results will be shown about the effect of a biocompatible shell of core-shell magnetite NPs on the heating properties by application of a RF magnetic field.

  19. Engineered magnetic nanoparticles for biomedical applications.

    Science.gov (United States)

    Canfarotta, Francesco; Piletsky, Sergey A

    2014-02-01

    In the past decades, magnetic nanoparticles (MNPs) have been used in wide range of diverse applications, ranging from separation to sensing. Here, synthesis and applications of functionalized MNPs in the biomedical field are discussed, in particular in drug delivery, imaging, and cancer therapy, highlighting also recent progresses in the development of multifunctional and stimuli-responsive MNPs. The role of their size, composition, and surface functionalization is analyzed, together with their biocompatibility issues. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Computer performance optimization systems, applications, processes

    CERN Document Server

    Osterhage, Wolfgang W

    2013-01-01

    Computing power performance was important at times when hardware was still expensive, because hardware had to be put to the best use. Later on this criterion was no longer critical, since hardware had become inexpensive. Meanwhile, however, people have realized that performance again plays a significant role, because of the major drain on system resources involved in developing complex applications. This book distinguishes between three levels of performance optimization: the system level, application level and business processes level. On each, optimizations can be achieved and cost-cutting p

  1. Connected vehicle applications : safety.

    Science.gov (United States)

    2016-01-01

    Connected vehicle safety applications are designed to increase situational awareness : and reduce or eliminate crashes through vehicle-to-infrastructure, vehicle-to-vehicle, : and vehicle-to-pedestrian data transmissions. Applications support advisor...

  2. Applicant Satisfaction Survey

    Data.gov (United States)

    Office of Personnel Management — The Chief Human Capital Officers developed 3 surveys that asks applicants to assess their satisfaction with the application process on a 1-10 point scale, with 10...

  3. Applications and extensions of degradation modeling

    International Nuclear Information System (INIS)

    Hsu, F.; Subudhi, M.; Samanta, P.K.; Vesely, W.E.

    1991-01-01

    Component degradation modeling being developed to understand the aging process can have many applications with potential advantages. Previous work has focused on developing the basic concepts and mathematical development of a simple degradation model. Using this simple model, times of degradations and failures occurrences were analyzed for standby components to detect indications of aging and to infer the effectiveness of maintenance in preventing age-related degradations from transforming to failures. Degradation modeling approaches can have broader applications in aging studies and in this paper, we discuss some of the extensions and applications of degradation modeling. The application and extension of degradation modeling approaches, presented in this paper, cover two aspects: (1) application to a continuously operating component, and (2) extension of the approach to analyze degradation-failure rate relationship. The application of the modeling approach to a continuously operating component (namely, air compressors) shows the usefulness of this approach in studying aging effects and the role of maintenance in this type component. In this case, aging effects in air compressors are demonstrated by the increase in both the degradation and failure rate and the faster increase in the failure rate compared to the degradation rate shows the ineffectiveness of the existing maintenance practices. Degradation-failure rate relationship was analyzed using data from residual heat removal system pumps. A simple linear model with a time-lag between these two parameters was studied. The application in this case showed a time-lag of 2 years for degradations to affect failure occurrences. 2 refs

  4. Applications and extensions of degradation modeling

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, F.; Subudhi, M.; Samanta, P.K. [Brookhaven National Lab., Upton, NY (United States); Vesely, W.E. [Science Applications International Corp., Columbus, OH (United States)

    1991-12-31

    Component degradation modeling being developed to understand the aging process can have many applications with potential advantages. Previous work has focused on developing the basic concepts and mathematical development of a simple degradation model. Using this simple model, times of degradations and failures occurrences were analyzed for standby components to detect indications of aging and to infer the effectiveness of maintenance in preventing age-related degradations from transforming to failures. Degradation modeling approaches can have broader applications in aging studies and in this paper, we discuss some of the extensions and applications of degradation modeling. The application and extension of degradation modeling approaches, presented in this paper, cover two aspects: (1) application to a continuously operating component, and (2) extension of the approach to analyze degradation-failure rate relationship. The application of the modeling approach to a continuously operating component (namely, air compressors) shows the usefulness of this approach in studying aging effects and the role of maintenance in this type component. In this case, aging effects in air compressors are demonstrated by the increase in both the degradation and failure rate and the faster increase in the failure rate compared to the degradation rate shows the ineffectiveness of the existing maintenance practices. Degradation-failure rate relationship was analyzed using data from residual heat removal system pumps. A simple linear model with a time-lag between these two parameters was studied. The application in this case showed a time-lag of 2 years for degradations to affect failure occurrences. 2 refs.

  5. Applications and extensions of degradation modeling

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, F.; Subudhi, M.; Samanta, P.K. (Brookhaven National Lab., Upton, NY (United States)); Vesely, W.E. (Science Applications International Corp., Columbus, OH (United States))

    1991-01-01

    Component degradation modeling being developed to understand the aging process can have many applications with potential advantages. Previous work has focused on developing the basic concepts and mathematical development of a simple degradation model. Using this simple model, times of degradations and failures occurrences were analyzed for standby components to detect indications of aging and to infer the effectiveness of maintenance in preventing age-related degradations from transforming to failures. Degradation modeling approaches can have broader applications in aging studies and in this paper, we discuss some of the extensions and applications of degradation modeling. The application and extension of degradation modeling approaches, presented in this paper, cover two aspects: (1) application to a continuously operating component, and (2) extension of the approach to analyze degradation-failure rate relationship. The application of the modeling approach to a continuously operating component (namely, air compressors) shows the usefulness of this approach in studying aging effects and the role of maintenance in this type component. In this case, aging effects in air compressors are demonstrated by the increase in both the degradation and failure rate and the faster increase in the failure rate compared to the degradation rate shows the ineffectiveness of the existing maintenance practices. Degradation-failure rate relationship was analyzed using data from residual heat removal system pumps. A simple linear model with a time-lag between these two parameters was studied. The application in this case showed a time-lag of 2 years for degradations to affect failure occurrences. 2 refs.

  6. Geant4 application in a Web browser

    International Nuclear Information System (INIS)

    Garnier, Laurent

    2014-01-01

    Geant4 is a toolkit for the simulation of the passage of particles through matter. The Geant4 visualization system supports many drivers including OpenGL[1], OpenInventor, HepRep[2], DAWN[3], VRML, RayTracer, gMocren[4] and ASCIITree, with diverse and complementary functionalities. Web applications have an increasing role in our work, and thanks to emerging frameworks such as Wt [5], building a web application on top of a C++ application without rewriting all the code can be done. Because the Geant4 toolkit's visualization and user interface modules are well decoupled from the rest of Geant4, it is straightforward to adapt these modules to render in a web application instead of a computer's native window manager. The API of the Wt framework closely matches that of Qt [6], our experience in building Qt driver will benefit for Wt driver. Porting a Geant4 application to a web application is easy, and with minimal effort, Geant4 users can replicate this process to share their own Geant4 applications in a web browser.

  7. Web Application Vulnerabilities

    OpenAIRE

    Yadav, Bhanu

    2014-01-01

    Web application security has been a major issue in information technology since the evolvement of dynamic web application. The main objective of this project was to carry out a detailed study on the top three web application vulnerabilities such as injection, cross site scripting, broken authentication and session management, present the situation where an application can be vulnerable to these web threats and finally provide preventative measures against them. ...

  8. Mobile food ordering application

    OpenAIRE

    Yang, Fan

    2014-01-01

    The purpose of this thesis was to build a food ordering client server application for Tom Yum Thai Oy, which is a Thai restaurant in Vaasa. For the customer, this application provides a view of current food information (category, name, image,price, description etc.) on the website and Android application. The customer can order food from these two platforms. For the administrator in restaurant, this application offers a series of operations to add, update, delete and query the information of ...

  9. Libros

    Directory of Open Access Journals (Sweden)

    Facultad de Medicina Revista

    1952-09-01

    Full Text Available Precis de Parasitologie Humaine / Sindromes Pathologiques du Nourrisson et. de L'enfant / Practique Neurnlogique / Precis D'Anatomie / Traite de Medecine / Traite de Therapeutique Chirurgicale

  10. Role of compressibility on driven magnetic reconnection

    International Nuclear Information System (INIS)

    Sato, T.; Hayashi, T.; Watanabe, K.; Horiuchi, R.; Tanaka, M.; Sawairi, N.; Kusano, K.

    1991-08-01

    Whether it is induced by an ideal (current driven) instability or by an external force, plasma flow causes a change in the magnetic field configuration and often gives rise to a current intensification locally, thereby a fast driven reconnection being driven there. Many dramatic phenomena in magnetically confined plasmas such as magnetospheric substorms, solar flares, MHD self-organization and tokamak sawtooth crash, may be attributed to this fast driven reconnection. Using a fourth order MHD simulation code it is confirmed that compressibility of the plasma plays a crucial role in leading to a fast (MHD time scale) driven reconnection. This indicates that the incompressible representation is not always applicable to the study of a global dynamical behavior of a magnetically confined plasma. (author)

  11. Changing family roles and marital instability.

    Science.gov (United States)

    Kharchev, A G; Matskovskii, M S

    1981-01-01

    The causes of divorce and its social and ethical consequences in Socialist and capitalist societies are examined in an attempt to improve the effectiveness of research on divorce, with a focus on changes in the family structure and the role of women. The impact of divorce on the institution of marriage, the lives of the divorced partners, the upbringing and character of children, and the reproductive processes of society is explored. Traditional notions and expectations of marriage and of duties within the family are identified. The possibility of changing attitudes in order to adapt to conditions resulting from scientific and technological progress is considered, with emphasis on ways of combining women's employment and the performance of household functions. Problems associated with the application of data obtained in foreign empirical studies to situations in the Soviet Union are addressed, and Western sociological approaches to the study of family dynamics are critically examined.

  12. Role of teleradiology in modern diagnostic imaging

    International Nuclear Information System (INIS)

    Chrzan, R.; Urbanik, A.; Wyrobek -Renczynska, M.; Podsiadlo, L.

    2004-01-01

    Teleradiology is a dynamically expanding technology of electronic transmission of radiologic images. History of teleradiology development, methods of obtaining images in digital form, media used for their transmission, factors affecting time of transmission, methods of visualization of transmitted images, attempts at standardization of new technology and at last typical applications of teleradiology were presented. Teleradiology from the position of technical curiosity advanced to the role of everyday work tool. Possibility of specialist diagnostic imaging assurance in poorly developed regions, not possessing sufficient number of radiologists, turned out particularly important. Cooperation of regional hospitals with specialist centers of diagnostic images reporting and archiving created a chance for making better use of owned equipment and reducing the costs of diagnostics. For the sake of broader and broader access to teleradiology not only over the world but also in Poland it is advisable to familiarize with its possibilities by both radiologists and clinicists using the results of diagnostic imaging. (author)

  13. Role of industry in international fusion program

    International Nuclear Information System (INIS)

    Durston, J.G.

    1997-01-01

    ITER combines a wide variety of technologies on an unprecedented scale of application. The experience of industry in design and integration of complex and advanced systems is helping to ensure that the engineering design of ITER is practicable and best meets the technical and cost objectives. The final development of fusion must take full benefit of the vast experience of industry in the management and coordination of major construction projects coupled with the fusion know-how being developed through participation in the ITER design activities. To achieve this, industry must be given an increasingly prominent role in the realization of the next-step device. The AE model provides an excellent means of achieving this aim. (author) 2 figs

  14. Optimizing memory use in Java applications, garbage collectors

    Directory of Open Access Journals (Sweden)

    Ştefan PREDA

    2016-05-01

    Full Text Available Java applications are diverse, depending by use case, exist application that use small amount of memory till application that use huge amount, tens or hundreds of gigabits. Java Virtual Machine is designed to automatically manage memory for applications. Even in this case due diversity of hardware, software that coexist on the same system and applications itself, these automatic decision need to be accompanied by developer or system administrator to triage optimal memory use. After developer big role to write optimum code from memory allocation perspective , optimizing memory use at Java Virtual Machine and application level become in last year's one of the most important task. This is explained in special due increased demand in applications scalability.

  15. Applications of Particle Accelerators in Medical Physics

    CERN Document Server

    Cuttone, G

    2008-01-01

    Particle accelerators are often associated to high energy or nuclear physics. As well pointed out in literature [1] if we kindly analyse the number of installation worldwide we can easily note that about 50% is mainly devoted to medical applications (radiotherapy, medical radioisotopes production, biomedical research). Particle accelerators are also playing an important indirect role considering the improvement of the technical features of medical diagnostic. In fact the use of radionuclide for advanced medical imaging is strongly increasing either in conventional radiography (CT and MRI) and also in nuclear medicine for Spect an PET imaging. In this paper role of particle accelerators for medical applications will be presented together with the main solutions applied.

  16. Antimicrobial Peptides: Multifunctional Drugs for Different Applications

    Directory of Open Access Journals (Sweden)

    Lea-Jessica Albrecht

    2012-02-01

    Full Text Available Antimicrobial peptides (APs are an important part of the innate immune system in epithelial and non-epithelial surfaces. So far, many different antimicrobial peptides from various families have been discovered in non-vertebrates and vertebrates. They are characterized by antibiotic, antifungal and antiviral activities against a variety of microorganisms. In addition to their role as endogenous antimicrobials, APs participate in multiple aspects of immunity. They are involved in septic and non-septic inflammation, wound repair, angiogenesis, regulation of the adaptive immune system and in maintaining homeostasis. Due to those characteristics AP could play an important role in many practical applications. Limited therapeutic efficiency of current antimicrobial agents and the emerging resistance of pathogens require alternate antimicrobial drugs. The purpose of this review is to highlight recent literature on functions and mechanisms of APs. It also shows their current practical applications as peptide therapeutics and bioactive polymers and discusses the possibilities of future clinical developments.

  17. THE ROLE OF MARKETING IN THE EDUCATION'S PROCESS

    Directory of Open Access Journals (Sweden)

    Baban Eleonora Gabriela

    2010-12-01

    Full Text Available Over time, marketing has become a propelling factor in any field of human activity, being also a primary tool in achieving the objectives of an organization. Identifying the main strategies in correlation with the marketing mix and its application on easy terms is a premise for each organization to achieve their targets. The essential objectives of the study are: 1. presenting the main functions of education, the role of marketing in education, 2 highlighting the main features of the education market in Romania; 3. presentation of the main strategies used by educational institutions in Romania; 4. application of marketing mix in education.

  18. The role of computer simulation in nuclear technologies development

    International Nuclear Information System (INIS)

    Tikhonchev, M.Yu.; Shimansky, G.A.; Lebedeva, E.E.; Lichadeev, V. V.; Ryazanov, D.K.; Tellin, A.I.

    2001-01-01

    In the report the role and purposes of computer simulation in nuclear technologies development is discussed. The authors consider such applications of computer simulation as nuclear safety researches, optimization of technical and economic parameters of acting nuclear plant, planning and support of reactor experiments, research and design new devices and technologies, design and development of 'simulators' for operating personnel training. Among marked applications the following aspects of computer simulation are discussed in the report: neutron-physical, thermal and hydrodynamics models, simulation of isotope structure change and damage dose accumulation for materials under irradiation, simulation of reactor control structures. (authors)

  19. The role of computer simulation in nuclear technology development

    International Nuclear Information System (INIS)

    Tikhonchev, M.Yu.; Shimansky, G.A.; Lebedeva, E.E.; Lichadeev, VV.; Ryazanov, D.K.; Tellin, A.I.

    2000-01-01

    In the report, the role and purpose of computer simulation in nuclear technology development is discussed. The authors consider such applications of computer simulation as: (a) Nuclear safety research; (b) Optimization of technical and economic parameters of acting nuclear plant; (c) Planning and support of reactor experiments; (d) Research and design new devices and technologies; (f) Design and development of 'simulators' for operating personnel training. Among marked applications, the following aspects of computer simulation are discussed in the report: (g) Neutron-physical, thermal and hydrodynamics models; (h) Simulation of isotope structure change and dam- age dose accumulation for materials under irradiation; (i) Simulation of reactor control structures. (authors)

  20. The effect of maternal role training program on role attainment and maternal role satisfaction in nulliparous women with unplanned pregnancy

    OpenAIRE

    Kordi, Masoumeh; Fasanghari, Maryam; Asgharipour, Negar; Esmaily, Habibollah

    2017-01-01

    INTRODUCTION: The maternal role is one of the most basic and important roles played by women during their lifetime. The process of the maternal role starts during pregnancy and to continue and develop after postpartum with the growth of suckling. However, unplanned pregnancy may jeopardize achieving the maternal role and reduce maternal role satisfaction. Therefore, the researcher conducted the present study to determine the impact of maternal role training program on attainment of role and r...

  1. Well logging. Acquisition and applications; Diagraphies. Acquisition et applications

    Energy Technology Data Exchange (ETDEWEB)

    Serra, O.; Serra, L.

    2001-07-01

    This reference book on wire-line and LWD well logging covers all geophysical methods of underground survey in a synthetic, visual and dynamical way. It treats of: the physical principle of well logging measurements, the different types of existing probes, the factors that can influence the measurements, and the applications of these measurements. The following well-logging methods are reviewed: resistivity; electromagnetic wave propagation; magnetic susceptibility and magnetic field; spontaneous potential; nuclear logging: natural gamma radioactivity, density logging, photoelectric index, neutron emission probes, hydrogen index or neutron porosity, neutron induced gamma spectroscopy, neutron relaxation time, NMR; acoustic measurements: sonic logging, seismic profiles; texture, structure and stratigraphy data acquisition; borehole diameter measurement; temperature measurement; wire sampling methods; place and role of well-logging in petroleum exploration; well-logging programs. (J.S.)

  2. SIMS applications workshop. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The first ANSTO/AINSE SIMS Workshop drew together a mixture of Surface Analysis experts and Surface Analysis users with the concept that SIMS analysis has to be enfolded within the spectrum of surface analysis techniques and that the user should select the technique most applicable to the problem. With this concept in mind the program was structured as sessions on SIMS Facilities; Applications to Mineral Surfaces; Applications to Biological Systems, Applications to Surfaces as Semi- conductors, Catalysts and Surface Coatings; and Applications to Ceramics

  3. Application Portable Parallel Library

    Science.gov (United States)

    Cole, Gary L.; Blech, Richard A.; Quealy, Angela; Townsend, Scott

    1995-01-01

    Application Portable Parallel Library (APPL) computer program is subroutine-based message-passing software library intended to provide consistent interface to variety of multiprocessor computers on market today. Minimizes effort needed to move application program from one computer to another. User develops application program once and then easily moves application program from parallel computer on which created to another parallel computer. ("Parallel computer" also include heterogeneous collection of networked computers). Written in C language with one FORTRAN 77 subroutine for UNIX-based computers and callable from application programs written in C language or FORTRAN 77.

  4. Division algebras, extended supersymmetries and applications

    International Nuclear Information System (INIS)

    Toppan, F.

    2001-03-01

    I present here some new results which make explicit the role of the division algebras R, C, H, O in the construction and classification of, respectively, N= 1, 2, 4, 8 global supersymmetric quantum mechanical and classical dynamical systems. In particular an N=8 Malcev superaffine algebra is introduced and its relation to the non-associative N = 8 SCA is discussed. A list of present and possible future applications is given. (author)

  5. Industrial applications of the Kalman filter

    DEFF Research Database (Denmark)

    Auger, François; Hilairet, Mickael; Guerrero, Josep M.

    2013-01-01

    The Kalman filter has received a huge interest from the industrial electronics community and has played a key role in many engineering fields since the 70s, ranging, without being exhaustive, trajectory estimation, state and parameter estimation for control or diagnosis, data merging, signal...... processing and so on. This paper provides a brief overview of the industrial applications and implementation issues of the Kalman filter in six topics of the industrial electronics community, highlighting some relevant reference papers and giving future research trends....

  6. Diode lasers and their applications in spectrometry

    International Nuclear Information System (INIS)

    Pavone, F.S.

    1997-01-01

    The impact of semiconductor diode laser in different fields ranging from communications to spectroscopy is becoming huge and pushes the research into developing sources satisfying the different requirements. For applications related to trace gas detection, the low amplitude noise in the light source of semiconductor diode laser is sufficient to obtain interesting results. Trace gas of molecular species as methane is interesting for different reason: it plays an important role in both radiative transport an photochemistry in the atmosphere

  7. Application of Motivation in English Teaching

    Institute of Scientific and Technical Information of China (English)

    朱瀚

    2006-01-01

    Teacher's words are not only a tool in teaching, but also an important resource of the language input for student at the same time.So it plays a very important role in the whole process of the teaching organization.The quantity and quality of teacher's words would directly affect the course.Moreover, motivation can usually bring much advantage to teaching.This thesis introduces the application of motivation in English teaching.

  8. Applications of Particle Accelerators in Medical Physics

    OpenAIRE

    Cuttone, G

    2008-01-01

    Particle accelerators are often associated to high energy or nuclear physics. As well pointed out in literature [1] if we kindly analyse the number of installation worldwide we can easily note that about 50% is mainly devoted to medical applications (radiotherapy, medical radioisotopes production, biomedical research). Particle accelerators are also playing an important indirect role considering the improvement of the technical features of medical diagnostic. In fact the use of radionuclide f...

  9. Division algebras, extended supersymmetries and applications

    International Nuclear Information System (INIS)

    Toppan, F.

    2001-01-01

    I present here some new results which make explicit the role of the division algebras R, C, H, O in the construction and classification of, respectively, N = 1, 2, 4, 8 global supersymmetric quantum mechanical and classical dynamical systems. In particular an N = 8 Malcev superaffine algebra is introduced and its relation to the non-associative N = 8 SCA is discussed. A list of present and possible future applications is given

  10. Z-Pinch Fusion for Energy Applications

    Energy Technology Data Exchange (ETDEWEB)

    SPIELMAN,RICK B.

    2000-01-01

    Z pinches, the oldest fusion concept, have recently been revisited in light of significant advances in the fields of plasma physics and pulsed power engineering. The possibility exists for z-pinch fusion to play a role in commercial energy applications. We report on work to develop z-pinch fusion concepts, the result of an extensive literature search, and the output for a congressionally-mandated workshop on fusion energy held in Snowmass, Co July 11-23,1999.

  11. Z-Pinch Fusion for Energy Applications

    International Nuclear Information System (INIS)

    SPIELMAN, RICK B.

    2000-01-01

    Z pinches, the oldest fusion concept, have recently been revisited in light of significant advances in the fields of plasma physics and pulsed power engineering. The possibility exists for z-pinch fusion to play a role in commercial energy applications. We report on work to develop z-pinch fusion concepts, the result of an extensive literature search, and the output for a congressionally-mandated workshop on fusion energy held in Snowmass, Co July 11-23,1999

  12. An Ontology for Knowledge Representation and Applications

    OpenAIRE

    Nhon Do

    2008-01-01

    Ontology is a terminology which is used in artificial intelligence with different meanings. Ontology researching has an important role in computer science and practical applications, especially distributed knowledge systems. In this paper we present an ontology which is called Computational Object Knowledge Base Ontology. It has been used in designing some knowledge base systems for solving problems such as the system that supports studying knowledge and solving analytic ...

  13. The cost - effective solar energy applications in Canada

    International Nuclear Information System (INIS)

    Pape, A.

    1999-01-01

    This paper outlines several cost-effective solar energy application in Canada, and estimates the GHG emission reduction potential for each. The applications include: (1) passive solar building design; (2) solar water heating applications; (3) solar photovoltaics for remote power; and (4) solar assisted space heating and cooling in industrial buildings. Each technology is briefly profiled in terms of functionality, cost characteristics, energy production characteristics and potential emission reduction benefits. Real-life examples of each application are also included. Finally, the paper concludes on the potential role of solar energy in the reduction of Canadian GHG emissions. (author)

  14. Criteria for Social Applications

    DEFF Research Database (Denmark)

    Atzenbeck, Claus; Tzagarakis, Manolis

    2007-01-01

    Social networks are becoming increasingly important for a wide number of applications. This is in particular true in the context of the Web 2.0 movement where a number of Web-based applications emerged - termed social networking applications or services - that allow the articulation of social...... relationships between individuals thus creating social networks. Although Web 2.0 applications are a popular and characteristic class of such applications they are not the only representatives that permit such functionality. Applications in the Personal Information Management domain exhibit similar...... characteristics but have never been mentioned in the context of social networking. The increasing number and diversity of such applications makes their study, analysis and evaluation from a systems point of view critical and important as their study may help identify relationships that are useful when attempting...

  15. Role of polyhydroxybutyrate in mitochondrial calcium uptake

    Science.gov (United States)

    Smithen, Matthew; Elustondo, Pia A.; Winkfein, Robert; Zakharian, Eleonora; Abramov, Andrey Y.; Pavlov, Evgeny

    2013-01-01

    Polyhydroxybutyrate (PHB) is a biological polymer which belongs to the class of polyesters and is ubiquitously present in all living organisms. Mammalian mitochondrial membranes contain PHB consisting of up to 120 hydroxybutyrate residues. Roles played by PHB in mammalian mitochondria remain obscure. It was previously demonstrated that PHB of the size similar to one found in mitochondria mediates calcium transport in lipid bilayer membranes. We hypothesized that the presence of PHB in mitochondrial membrane might play a significant role in mitochondrial calcium transport. To test this, we investigated how the induction of PHB hydrolysis affects mitochondrial calcium transport. Mitochondrial PHB was altered enzymatically by targeted expression of bacterial PHB hydrolyzing enzyme (PhaZ7) in mitochondria of mammalian cultured cells. The expression of PhaZ7 induced changes in mitochondrial metabolism resulting in decreased mitochondrial membrane potential in HepG2 but not in U87 and HeLa cells. Furthermore, it significantly inhibited mitochondrial calcium uptake in intact HepG2, U87 and HeLa cells stimulated by the ATP or by the application of increased concentrations of calcium to the digitonin permeabilized cells. Calcium uptake in PhaZ7 expressing cells was restored by mimicking calcium uniporter properties with natural electrogenic calcium ionophore - ferutinin. We propose that PHB is a previously unrecognized important component of the mitochondrial calcium uptake system. PMID:23702223

  16. Occupational Therapy's Role with Autism

    Science.gov (United States)

    Fact Sheet Occupational Therapy’s Role with Autism Autism is a lifelong condition associated with a varied course from early childhood through adulthood. Occupational therapy practitioners are distinctly qualified to ...

  17. CULTURE AND GENDER ROLE DIFFERENCES

    Directory of Open Access Journals (Sweden)

    Angelica-Nicoleta NECULĂESEI (ONEA

    2015-06-01

    Full Text Available Culture influences thinking, language and human behaviour. The social environment, in which individuals are born and live, shapes their attitudinal, emotional and behavioural reactions and the perceptions about what is happening around. The same applies in the case of assigned/assumed roles in society based on gender. Cultural dimensions that reflect differences in gender roles, but also elements related to the ethics of sexual difference were highlighted by many researchers. The presentation of these issues from the interdisciplinary perspective is the subject of this article. Briefly, the article refers to: importance of communication in transmission of roles of those two sexes, cultural dimensions that reflect role differences invarious cultures, discrimination issues and ethics of sexual difference.

  18. CULTURE AND GENDER ROLE DIFFERENCES

    OpenAIRE

    Angelica-Nicoleta NECULĂESEI (ONEA)

    2015-01-01

    Culture influences thinking, language and human behaviour. The social environment, in which individuals are born and live, shapes their attitudinal, emotional and behavioural reactions and the perceptions about what is happening around. The same applies in the case of assigned/assumed roles in society based on gender. Cultural dimensions that reflect differences in gender roles, but also elements related to the ethics of sexual difference were highlighted by many researchers. The presentation...

  19. The roles of viruses in periodontal diseases

    OpenAIRE

    C C Azodo; P Erhabor

    2015-01-01

    The roles of bacteria in the etiopathogenesis of periodontal disease are well-understand, but that of the virus found in the periodontal environment are poorly understood. The aim of this literature review was to report the roles of viruses in periodontal diseases. The roles of viruses in periodontal diseases were categorized into the role in disease etiology, role in the pathogenesis of periodontal diseases, role in diseases progression and role in response to treatment. Clearer understandin...

  20. Electronic Submissions of Pesticide Applications

    Science.gov (United States)

    Applications for pesticide registration can be submitted electronically, including forms, studies, and draft product labeling. Applicants need not submit multiple electronic copies of any pieces of their applications.

  1. Wood energy-commercial applications

    Science.gov (United States)

    Kennel, R. P.

    1978-01-01

    Wood energy is being widely investigated in many areas of the country because of the many obvious benefits of wood fuel such as the low price per million Btus relative to coal, oil, and gas; the wide availability of noncommercial wood and the proven ability to harvest it; established technology which is reliable and free of pollution; renewable resources; better conservation for harvested land; and the potential for jobs creation. The Southeastern United States has a specific leadership role in wood energy based on its established forest products industry experience and the potential application of wood energy to other industries and institutions. Significant questions about the widespread usage of wood energy are being answered in demonstrations around the country as well as the Southeast in areas of wood storage and bulk handling; high capitalization costs for harvesting and combustion equipment; long term supply and demand contracts; and the economic feasibility of wood energy outside the forest products industry.

  2. Conference on Inequalities and Applications

    CERN Document Server

    Losonczi, László; Gilányi, Attila; Páles, Zsolt; Plum, Michael

    2009-01-01

    Inequalities continue to play an essential role in mathematics. Perhaps, they form the last field comprehended and used by mathematicians in all areas of the discipline. Since the seminal work Inequalities (1934) by Hardy, Littlewood and Pólya, mathematicians have laboured to extend and sharpen their classical inequalities. New inequalities are discovered every year, some for their intrinsic interest whilst others flow from results obtained in various branches of mathematics. The study of inequalities reflects the many and various aspects of mathematics. On one hand, there is the systematic search for the basic principles and the study of inequalities for their own sake. On the other hand, the subject is the source of ingenious ideas and methods that give rise to seemingly elementary but nevertheless serious and challenging problems. There are numerous applications in a wide variety of fields, from mathematical physics to biology and economics. This volume contains the contributions of the participants of th...

  3. CFD applications in hypersonic flight

    Science.gov (United States)

    Edwards, T. A.

    1992-01-01

    Design studies are underway for a variety of hypersonic flight vehicles. The National Aero-Space Plane will provide a reusable, single-stage-to-orbit capability for routine access to low earth orbit. Flight-capable satellites will dip into the atmosphere to maneuver to new orbits, while planetary probes will decelerate at their destination by atmospheric aerobraking. To supplement limited experimental capabilities in the hypersonic regime, CFD is being used to analyze the flow about these configurations. The governing equations include fluid dynamic as well as chemical species equations, which are solved with robust upwind differencing schemes. Examples of CFD applications to hypersonic vehicles suggest an important role this technology will play in the development of future aerospace systems. The computational resources needed to obtain solutions are large, but various strategies are being exploited to reduce the time required for complete vehicle simulations.

  4. Cold neutron production and application

    International Nuclear Information System (INIS)

    Inoue, Kazuhiko; Watanabe, Noboru.

    1976-01-01

    The first part gives general introduction to cold neutrons, namely the definition and the role as a probe in basic science and technology. The second part reviews various methods of cold neutron production. Some physical characteristics required for cold moderators are presented, and a list summarizes a number of cold moderators and their reactor physics constants. The definition of flux gain factor and the measured values for liquid light- and heavy-hydrogen are also given. The cold neutron spectra in methane and liquid hydrogen measured by LINAC time-of-flight method are presented to show the advantage of solid methane. The cold neutron sources using experimental reactors or linear accelerators are explained along with the examples of existing facilities. Two Japanese programs, the one is the use of a high flux reactor and the other is the use of a LINAC, are also presented. The third part of this report reviews the application areas of cold neutrons. (Aoki, K.)

  5. Food irradiation: chemistry and applications

    International Nuclear Information System (INIS)

    Thakur, B.R.; Singh, R.K.

    1994-01-01

    Food irradiation is one of the most extensively and thoroughly studied methods of food preservation. Despite voluminous data on safety and wholesomeness of irradiated foods, food irradiation is still a “process in waiting.” Although some countries are allowing the use of irradiation technology on certain foods, its full potential is not recognized. Only 37 countries worldwide permit the use of this technology. If used to its full potential, food irradiation can save millions of human lives being lost annually due to food‐borne diseases or starvation and can add billions of dollars to the world economy. This paper briefly reviews the history and chemistry of food irradiation along with its main applications, impediments to its adoption, and its role in improving food availability and health situation, particularly in developing countries of the world

  6. An experimental study comparing the role played by the ‘pre-experience’ and the ‘post-experience’ phases in respect with ‘perception’ and ‘memory’ to test the practical application of Perception Experience Memory Model of advertising.

    OpenAIRE

    Ghiya, Krishn/ KG

    2015-01-01

    This study aims to bridge the gap between the theoretical and practical applications between the theories of advertising. After comparing and contrasting the Elaboration Likelihood Model (ELM) (Petty, et al., 1983), the Information Processing Model (Engel, et al., 1993) and the Perception Experience Memory (PEM) model (Hall, 2002) of advertising, the research became more focussed towards the PEM model. Although, this relatively newer theory is a combination of merits of the ELM and the IPM, i...

  7. Applications of noise analysis to nuclear safety

    International Nuclear Information System (INIS)

    Aguilar Martinez, Omar

    2000-01-01

    Noise Analysis techniques (analysis of the fluctuation of physical parameters) have been successfully applied to the operational vigilance of the technical equipment that plays a decisive role in the production cycle of a very complex industry. Although fluctuation measurements in nuclear installations started almost at the start of the nuclear era (see works by Feynman and Rossi on the development of neutron methodology), only recently have neutron noise diagnostic applications begun to be a part of the standard procedures for the performance of some modern nuclear installations. Following the relevant technical advances made in information sciences and analogical electronics, measuring the fluctuation of physical parameters has become a very effective tool for detecting, guarding and following up possible defects in a nuclear system. As the processing techniques for the fluctuation of a nuclear reactor's physical-neutron parameters have evolved (temporal and frequency analysis, multi-parameter self -regression analysis, etc.), the applications of the theory of non-lineal dynamics and chaos theory have progressed by focusing on the problem from another perspective. This work reports on those nuclear applications of noise analysis that increase nuclear safety in all types of nuclear facilities and that have been carried out by the author over the last decade, such as: -Void Force Critical Set Applications (Zero Power Reactor Applications, Central Institute of Physical Research, Budapest, Hungary); -Research Reactor Applications (Triga Mark III Reactor, National Institute of Nuclear Research, ININ, Mexico); -Power Reactor Applications in a Nuclear Power Plant (First Circuit of Block II, Paks Nuclear Center, Hungary); -Second Loop applications in a Nuclear Power Plant (Block I Paks Nuclear Center, Hungary; Block II Kalinin Nuclear Center, Russia); -Shield System Applications for the Transport of Radioisotopes (Nuclear Technology Center, Havana, Cuba) New trends in

  8. Use of professional profiles in applications for specialist training positions

    DEFF Research Database (Denmark)

    Lundh, Andreas; Skjelsager, Karen; Wildgaard, Kim

    2013-01-01

    INTRODUCTION: The seven roles of the CanMEDS system have been implemented in Danish postgraduate medical training. For each medical specialty, a professional profile describes which elements of the seven roles the specialty deems important for applicants for a specialist training position. We...... investigated use of professional profiles among the 38 Danish specialty societies in order to ascertain the use of the seven roles. MATERIAL AND METHODS: We used information from the websites of the Postgraduate Medical Training Secretariats in March 2012. For each profile, we extracted information on how...... the seven roles were described, how the roles were ranked by importance, whether a score sheet was used by the appointment committee and whether the profile had been updated. RESULTS: Twenty-four (63%) of the 38 profiles described the contents for all of the seven roles and four (11%) described the contents...

  9. The role of psychiatry in family violence treatment

    OpenAIRE

    Nastasić, Petar; Hrnčić, Jasna; Brkić, Miroslav

    2013-01-01

    The aim of the paper is reassessment of the role of psychiatry in the treatment of family violence within the context of contemporary approaches and researches. There are prejudices in the general and professional public that perpetrators of family violence are usually persons with mental disorders and that psychiatry is primarily in charge of their treatment; it has been shown that severe mental disorders do not increase the risk of violence. Application of classical psychiatrics appro...

  10. Nitrilase enzymes and their role in plant–microbe interactions

    OpenAIRE

    Howden, Andrew J. M.; Preston, Gail M.

    2009-01-01

    Summary Nitrilase enzymes (nitrilases) catalyse the hydrolysis of nitrile compounds to the corresponding carboxylic acid and ammonia, and have a wide range of industrial and biotechnological applications, including the synthesis of industrially important carboxylic acids and bioremediation of cyanide and toxic nitriles. Nitrilases are produced by a wide range of organisms, including plants, bacteria and fungi, but despite their biotechnological importance, the role of these enzymes in living ...

  11. The role of computed tomography in modern paediatric uroradiology

    Energy Technology Data Exchange (ETDEWEB)

    Maudgil, D.D.; McHugh, K. E-mail: kmchugh@gosh.nhs.uk

    2002-08-01

    Computed tomography (CT) has developed a well-recognised role within paediatric uroradiology, especially in imaging of trauma, malignancy (in particular Wilms' tumour), atypical infection, and congenital urogenital abnormalities. CT can also be used for problem solving in nephrolithiasis and renal transplant assessment. These applications are illustrated and discussed, with an emphasis on particular information that can be gained from the CT study.

  12. Transforming poison into medicine: the role of dualism in psychiatry.

    Science.gov (United States)

    Marinoff, Lou

    2011-09-01

    This article draws attention to a generalizable phenomenon called "transforming poison into medicine," illustrating both literal and figurative applications. The purpose of such illustrations is to support a strong philosophical claim, namely the currently incomplete reduction (if not the ultimate irreducibility) of intentional mind-states - e.g., beliefs, desires, volitions - to electro-chemical brain-states. Such incomplete reduction (or irreducibility) holds profound implications for the ineluctable role of dualism in neuroscience and psychiatry alike.

  13. Nevada`s role in the hydrogen economy

    Energy Technology Data Exchange (ETDEWEB)

    Vaeth, T. [Dept. of Energy, Las Vegas, NV (United States)

    1997-12-31

    The paper discusses the promise of hydrogen and its possible applications, barriers to its development, the role that the Nevada Test Site could play if it were made more available to public and private institutions for research, and the ``clean city`` concept being developed jointly with California, Utah, and Nevada. This concept would create a ``clean corridor`` along the route from Salt Lake City through Reno to Sacramento, Los Angeles, Las Vegas, and back to Salt Lake City.

  14. Role of Interfaces in Mechanical Properties of Polycrystalline Materials

    Indian Academy of Sciences (India)

    Commercial Applications · Slide 9 · Slide 10 · Grain Boundary Sliding and Slip · Slide 12 · Slide 13 · Role of Grain Boundaries · Superplasticity in Zirconia · Slide 16 · Slide 17 · Slide 18 · Slide 19 · Scaling Relationship · Slide 21 · Slide 22 · Slide 23 · Slide 24 · Slide 25 · Slide 26 · Slide 27 · Slide 28 · Creep in Electrodeposited ...

  15. Performance Evaluation Model for Application Layer Firewalls.

    Science.gov (United States)

    Xuan, Shichang; Yang, Wu; Dong, Hui; Zhang, Jiangchuan

    2016-01-01

    Application layer firewalls protect the trusted area network against information security risks. However, firewall performance may affect user experience. Therefore, performance analysis plays a significant role in the evaluation of application layer firewalls. This paper presents an analytic model of the application layer firewall, based on a system analysis to evaluate the capability of the firewall. In order to enable users to improve the performance of the application layer firewall with limited resources, resource allocation was evaluated to obtain the optimal resource allocation scheme in terms of throughput, delay, and packet loss rate. The proposed model employs the Erlangian queuing model to analyze the performance parameters of the system with regard to the three layers (network, transport, and application layers). Then, the analysis results of all the layers are combined to obtain the overall system performance indicators. A discrete event simulation method was used to evaluate the proposed model. Finally, limited service desk resources were allocated to obtain the values of the performance indicators under different resource allocation scenarios in order to determine the optimal allocation scheme. Under limited resource allocation, this scheme enables users to maximize the performance of the application layer firewall.

  16. Performance Evaluation Model for Application Layer Firewalls.

    Directory of Open Access Journals (Sweden)

    Shichang Xuan

    Full Text Available Application layer firewalls protect the trusted area network against information security risks. However, firewall performance may affect user experience. Therefore, performance analysis plays a significant role in the evaluation of application layer firewalls. This paper presents an analytic model of the application layer firewall, based on a system analysis to evaluate the capability of the firewall. In order to enable users to improve the performance of the application layer firewall with limited resources, resource allocation was evaluated to obtain the optimal resource allocation scheme in terms of throughput, delay, and packet loss rate. The proposed model employs the Erlangian queuing model to analyze the performance parameters of the system with regard to the three layers (network, transport, and application layers. Then, the analysis results of all the layers are combined to obtain the overall system performance indicators. A discrete event simulation method was used to evaluate the proposed model. Finally, limited service desk resources were allocated to obtain the values of the performance indicators under different resource allocation scenarios in order to determine the optimal allocation scheme. Under limited resource allocation, this scheme enables users to maximize the performance of the application layer firewall.

  17. Evolving technologies drive the new roles of Biomedical Engineering.

    Science.gov (United States)

    Frisch, P H; St Germain, J; Lui, W

    2008-01-01

    Rapidly changing technology coupled with the financial impact of organized health care, has required hospital Biomedical Engineering organizations to augment their traditional operational and business models to increase their role in developing enhanced clinical applications utilizing new and evolving technologies. The deployment of these technology based applications has required Biomedical Engineering organizations to re-organize to optimize the manner in which they provide and manage services. Memorial Sloan-Kettering Cancer Center has implemented a strategy to explore evolving technologies integrating them into enhanced clinical applications while optimally utilizing the expertise of the traditional Biomedical Engineering component (Clinical Engineering) to provide expanded support in technology / equipment management, device repair, preventive maintenance and integration with legacy clinical systems. Specifically, Biomedical Engineering is an integral component of the Medical Physics Department which provides comprehensive and integrated support to the Center in advanced physical, technical and engineering technology. This organizational structure emphasizes the integration and collaboration between a spectrum of technical expertise for clinical support and equipment management roles. The high cost of clinical equipment purchases coupled with the increasing cost of service has driven equipment management responsibilities to include significant business and financial aspects to provide a cost effective service model. This case study details the dynamics of these expanded roles, future initiatives and benefits for Biomedical Engineering and Memorial Sloan Kettering Cancer Center.

  18. Theory of reproducing kernels and applications

    CERN Document Server

    Saitoh, Saburou

    2016-01-01

    This book provides a large extension of the general theory of reproducing kernels published by N. Aronszajn in 1950, with many concrete applications. In Chapter 1, many concrete reproducing kernels are first introduced with detailed information. Chapter 2 presents a general and global theory of reproducing kernels with basic applications in a self-contained way. Many fundamental operations among reproducing kernel Hilbert spaces are dealt with. Chapter 2 is the heart of this book. Chapter 3 is devoted to the Tikhonov regularization using the theory of reproducing kernels with applications to numerical and practical solutions of bounded linear operator equations. In Chapter 4, the numerical real inversion formulas of the Laplace transform are presented by applying the Tikhonov regularization, where the reproducing kernels play a key role in the results. Chapter 5 deals with ordinary differential equations; Chapter 6 includes many concrete results for various fundamental partial differential equations. In Chapt...

  19. Role of nuclear safety research and future plan

    International Nuclear Information System (INIS)

    Kim, W. S.; Lee, J. I.; Kang, S. C.; Park, Y. W.; Lee, J. H.; Kim, M. W.; Lee, C. J.; Park, Y. I.

    2000-01-01

    For promoting and improving nuclear safety research activities, this report gives an insight on the scope of safety research and its role in the safety management of nuclear installations, and suggests measures to adequately utilize the research results through taking an optimized role share among research organizations. Several measures such as cooperative planning of common research areas and proper role assignment, improvement of the interfaces among researchers, and reflection of end-users' opinion in the course of planning and conducting research to promote application of research results are identified. It is expected that the identified measures will contribute to enhancing the efficiency and effectiveness of nuclear safety research, if they are implemented after deliberating with the government and safety research organizations

  20. Role of Bioreactors in Microbial Biomass and Energy Conversion

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Liang [Chongqing University, Chongqing, China; Zhang, Biao [Chongqing University, Chongqing, China; Zhu, Xun [Chongqing University, Chongqing, China; Chang, Haixing [Chongqing University of Technology; Ou, Shawn [ORNL; Wang, HONG [Chongqing University, Chongqing, China

    2018-04-01

    Bioenergy is the world’s largest contributor to the renewable and sustainable energy sector, and it plays a significant role in various energy industries. A large amount of research has contributed to the rapidly evolving field of bioenergy and one of the most important topics is the use of the bioreactor. Bioreactors play a critical role in the successful development of technologies for microbial biomass cultivation and energy conversion. In this chapter, after a brief introduction to bioreactors (basic concepts, configurations, functions, and influencing factors), the applications of the bioreactor in microbial biomass, microbial biofuel conversion, and microbial electrochemical systems are described. Importantly, the role and significance of the bioreactor in the bioenergy process are discussed to provide a better understanding of the use of bioreactors in managing microbial biomass and energy conversion.

  1. Nuclear data for medical applications

    International Nuclear Information System (INIS)

    Capote, Roberto

    2011-01-01

    Nuclear science plays an increasingly important role in medical applications, in particular the need for radioisotopes in both cancer therapy and diagnostic techniques is very well established. Over the previous thirty years, many laboratories have reported a significant body of experimental data relevant to medical radionuclide production, and international data centres have compiled most of these data. However, till late 90s no systematic effort had been devoted to their standardization and assembly. These needs are being addressed through three IAEA Coordinated Research Projects on Nuclear Data for the Production of Radionuclides that started in 1999. Monitor cross sections to be used in charged particle measurements have been also evaluated (see http://www-nds.iaea.org/medical/monitor reactions.html). A review of IAEA recommended cross sections for the production of medical radioisotopes will be presented. Theoretical modelling of nuclear reactions will be discussed both for nuclear data evaluation and validation. The role of the Recommended Input Parameter Library (RIPL) in defining the input for production codes like EMPIRE and TALYS will be highlighted. (author)

  2. Technical applications of aerogels

    International Nuclear Information System (INIS)

    Hrubesh, L.W.

    1997-01-01

    Aerogel materials posses such a wide variety of exceptional properties that a striking number of applications have developed for them. Many of the commercial applications of aerogels such as catalysts, thermal insulation, windows, and particle detectors are still under development and new application as have been publicized since the ISA4 Conference in 1994: e.g.; supercapacitors, insulation for heat storage in automobiles, electrodes for capacitive deionization, etc. More applications are evolving as the scientific and engineering community becomes familiar with the unusual and exceptional physical properties of aerogels, there are also scientific and technical application, as well. This paper discusses a variety of applications under development at Lawrence Livermore National Laboratory for which several types of aerogels are formed in custom sizes and shapes. Particular discussions will focus on the uses of aerogels for physics experiments which rely on the exceptional, sometimes unique, properties of aerogels

  3. Industrial Application of Accelerators

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    At CERN, we are very familiar with large, high energy particle accelerators. However, in the world outside CERN, there are more than 35000 accelerators which are used for applications ranging from treating cancer, through making better electronics to removing harmful micro-organisms from food and water. These are responsible for around $0.5T of commerce each year. Almost all are less than 20 MeV and most use accelerator types that are somewhat different from what is at CERN. These lectures will describe some of the most common applications, some of the newer applications in development and the accelerator technology used for them. It will also show examples of where technology developed for particle physics is now being studied for these applications. Rob Edgecock is a Professor of Accelerator Science, with a particular interest in the medical applications of accelerators. He works jointly for the STFC Rutherford Appleton Laboratory and the International Institute for Accelerator Applications at the Univer...

  4. Industrial Application of Accelerators

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    At CERN, we are very familiar with large, high energy particle accelerators. However, in the world outside CERN, there are more than 35000 accelerators which are used for applications ranging from treating cancer, through making better electronics to removing harmful micro-organisms from food and water. These are responsible for around $0.5T of commerce each year. Almost all are less than 20 MeV and most use accelerator types that are somewhat different from what is at CERN. These lectures will describe some of the most common applications, some of the newer applications in development and the accelerator technology used for them. It will also show examples of where technology developed for particle physics is now being studied for these applications. Rob Edgecock is a Professor of Accelerator Science, with a particular interest in the medical applications of accelerators. He works jointly for the STFC Rutherford Appleton Laboratory and the International Institute for Accelerator Applications at the Uni...

  5. Applications of Photocatalytic Disinfection

    Directory of Open Access Journals (Sweden)

    Joanne Gamage

    2010-01-01

    Full Text Available Due to the superior ability of photocatalysis to inactivate a wide range of harmful microorganisms, it is being examined as a viable alternative to traditional disinfection methods such as chlorination, which can produce harmful byproducts. Photocatalysis is a versatile and effective process that can be adapted for use in many applications for disinfection in both air and water matrices. Additionally, photocatalytic surfaces are being developed and tested for use in the context of “self-disinfecting” materials. Studies on the photocatalytic technique for disinfection demonstrate this process to have potential for widespread applications in indoor air and environmental health, biological, and medical applications, laboratory and hospital applications, pharmaceutical and food industry, plant protection applications, wastewater and effluents treatment, and drinking water disinfection. Studies on photocatalytic disinfection using a variety of techniques and test organisms are reviewed, with an emphasis on the end-use application of developed technologies and methods.

  6. Theoretical aspects of business role-playing game for senior students

    Directory of Open Access Journals (Sweden)

    Faychuk Olena Leonidivna

    2015-04-01

    Full Text Available The article deals with some theoretically grounded features of the business role-playing game determined to improve the learning process of senior students (specialization «Social work». The authors give the classification of business role-playing games, benefits and effective application of the rules of role-plays, and possibilities of using them in the learning process. Business role-playing games provide students’ initiative, emotional saturation of the learning process and help to assimilate the basic theoretical knowledge.

  7. Objective assessment of gender roles: Gender Roles Test (GRT-36).

    Science.gov (United States)

    Fernández, Juan; Quiroga, M Angeles; del Olmo, Isabel; Aróztegui, Javier; Martín, Arantxa

    2011-11-01

    This study was designed to develop a computerized test to assess gender roles. This test is presented as a decision-making task to mask its purpose. Each item displays a picture representing an activity and a brief sentence that describes it. Participants have to choose the most suitable sex to perform each activity: man or woman. The test (Gender Roles Test, GRT-36) consists of 36 items/activities. The program registers both the choices made and their response times (RTs). Responses are considered as stereotyped when the chosen sex fits stereotyped roles and non-stereotyped when the chosen sex does not fit stereotyped roles. Individual means (RTs) were computed for stereotyped and non-stereotyped responses, differentiating between domestic and work spheres. A "D" score, reflecting the strength of association between activities and sex, was calculated for each sphere and sex. The study incorporated 78 participants (69% women and 31% men) ranging from 19 to 59 years old. The results show that: (a) reading speed does not explain the variability in the RTs; (b) RTs show good internal consistency; (c) RTs are shorter for stereotyped than for neutral stimuli; (d) RTs are shorter for stereotyped than for non-stereotyped responses. Intended goals are supported by obtained results. Scores provided by the task facilitate both group and individual detailed analysis of gender role, differentiating the gender role assigned to men from that assigned to women, at the domestic and work spheres. Obtained data fall within the scope of the genderology and their implications are discussed.

  8. Support vector machines applications

    CERN Document Server

    Guo, Guodong

    2014-01-01

    Support vector machines (SVM) have both a solid mathematical background and good performance in practical applications. This book focuses on the recent advances and applications of the SVM in different areas, such as image processing, medical practice, computer vision, pattern recognition, machine learning, applied statistics, business intelligence, and artificial intelligence. The aim of this book is to create a comprehensive source on support vector machine applications, especially some recent advances.

  9. Microprocessors principles and applications

    CERN Document Server

    Debenham, Michael J

    1979-01-01

    Microprocessors: Principles and Applications deals with the principles and applications of microprocessors and covers topics ranging from computer architecture and programmed machines to microprocessor programming, support systems and software, and system design. A number of microprocessor applications are considered, including data processing, process control, and telephone switching. This book is comprised of 10 chapters and begins with a historical overview of computers and computing, followed by a discussion on computer architecture and programmed machines, paying particular attention to t

  10. Applications of combinatorial optimization

    CERN Document Server

    Paschos, Vangelis Th

    2013-01-01

    Combinatorial optimization is a multidisciplinary scientific area, lying in the interface of three major scientific domains: mathematics, theoretical computer science and management. The three volumes of the Combinatorial Optimization series aims to cover a wide range of topics in this area. These topics also deal with fundamental notions and approaches as with several classical applications of combinatorial optimization. "Applications of Combinatorial Optimization" is presenting a certain number among the most common and well-known applications of Combinatorial Optimization.

  11. Android Applications Security

    OpenAIRE

    Paul POCATILU

    2011-01-01

    The use of smartphones worldwide is growing very fast and also the malicious attacks have increased. The mobile security applications development keeps the pace with this trend. The paper presents the vulnerabilities of mobile applications. The Android applications and devices are analyzed through the security perspective. The usage of restricted API is also presented. The paper also focuses on how users can prevent these malicious attacks and propose some prevention measures, including the a...

  12. Galileo Timing Applications

    Science.gov (United States)

    2007-11-01

    public bodies like university and research institutes. The user community analysis also includes a market analysis performed by a specialized company to... companies and public institutions (e.g., universities, research laboratories) that work in several different application domains in order to virtually...Summary of application domains for the use of time in cryptography. B2G B2B B2C Applications Military waypoints, judicial reports, construction

  13. Refrigeration systems and applications

    CERN Document Server

    Dincer, Ibrahim

    2010-01-01

    Refrigeration Systems and Applications, 2nd edition offers a comprehensive treatise that addresses real-life technical and operational problems, enabling the reader to gain an understanding of the fundamental principles and the practical applications of refrigeration technology. New and unique analysis techniques (including exergy as a potential tool), models, correlations, procedures and applications are covered, and recent developments in the field are included - many of which are taken from the author's own research activities in this area. The book also includes so

  14. Exploiting chaos for applications

    Energy Technology Data Exchange (ETDEWEB)

    Ditto, William L., E-mail: wditto@hawaii.edu [Department of Physics and Astronomy, University of Hawaii at Mānoa, Honolulu, Hawaii 96822 (United States); Sinha, Sudeshna, E-mail: sudeshna@iisermohali.ac.in [Indian Institute of Science Education and Research (IISER), Mohali, Knowledge City, Sector 81, SAS Nagar, PO Manauli 140306, Punjab (India)

    2015-09-15

    We discuss how understanding the nature of chaotic dynamics allows us to control these systems. A controlled chaotic system can then serve as a versatile pattern generator that can be used for a range of application. Specifically, we will discuss the application of controlled chaos to the design of novel computational paradigms. Thus, we present an illustrative research arc, starting with ideas of control, based on the general understanding of chaos, moving over to applications that influence the course of building better devices.

  15. Microcomputer interfacing and applications

    CERN Document Server

    Mustafa, M A

    1990-01-01

    This is the applications guide to interfacing microcomputers. It offers practical non-mathematical solutions to interfacing problems in many applications including data acquisition and control. Emphasis is given to the definition of the objectives of the interface, then comparing possible solutions and producing the best interface for every situation. Dr Mustafa A Mustafa is a senior designer of control equipment and has written many technical articles and papers on the subject of computers and their application to control engineering.

  16. Exploiting chaos for applications.

    Science.gov (United States)

    Ditto, William L; Sinha, Sudeshna

    2015-09-01

    We discuss how understanding the nature of chaotic dynamics allows us to control these systems. A controlled chaotic system can then serve as a versatile pattern generator that can be used for a range of application. Specifically, we will discuss the application of controlled chaos to the design of novel computational paradigms. Thus, we present an illustrative research arc, starting with ideas of control, based on the general understanding of chaos, moving over to applications that influence the course of building better devices.

  17. Application Layer Multicast

    Science.gov (United States)

    Allani, Mouna; Garbinato, Benoît; Pedone, Fernando

    An increasing number of Peer-to-Peer (P2P) Internet applications rely today on data dissemination as their cornerstone, e.g., audio or video streaming, multi-party games. These applications typically depend on some support for multicast communication, where peers interested in a given data stream can join a corresponding multicast group. As a consequence, the efficiency, scalability, and reliability guarantees of these applications are tightly coupled with that of the underlying multicast mechanism.

  18. REST based mobile applications

    Science.gov (United States)

    Rambow, Mark; Preuss, Thomas; Berdux, Jörg; Conrad, Marc

    2008-02-01

    Simplicity is the major advantage of REST based webservices. Whereas SOAP is widespread in complex, security sensitive business-to-business aplications, REST is widely used for mashups and end-user centric applicatons. In that context we give an overview of REST and compare it to SOAP. Furthermore we apply the GeoDrawing application as an example for REST based mobile applications and emphasize on pros and cons for the use of REST in mobile application scenarios.

  19. Irregular Applications: Architectures & Algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Feo, John T.; Villa, Oreste; Tumeo, Antonino; Secchi, Simone

    2012-02-06

    Irregular applications are characterized by irregular data structures, control and communication patterns. Novel irregular high performance applications which deal with large data sets and require have recently appeared. Unfortunately, current high performance systems and software infrastructures executes irregular algorithms poorly. Only coordinated efforts by end user, area specialists and computer scientists that consider both the architecture and the software stack may be able to provide solutions to the challenges of modern irregular applications.

  20. Applications of Nanotechnology in Dermatology

    Science.gov (United States)

    DeLouise, Lisa A.

    2014-01-01

    What are nanoparticles and why are they important in dermatology? These questions are addressed by highlighting recent developments in the nanotechnology field that have increased the potential for intentional and unintended nanoparticle skin exposure. The role of environmental factors in the interaction of nanoparticles with skin and the potential mechanisms by which nanoparticles may influence skin response to environmental factors are discussed. Trends emerging from recent literature suggest that the positive benefit of engineered nanoparticles for use in cosmetics and as tools for understanding skin biology and curing skin disease, out weigh potential toxicity concerns. Discoveries reported in this journal are highlighted. This review begins with a general introduction to the field of nanotechnology and nanomedicine. This is followed by a discussion of the current state of understanding of nanoparticle skin penetration and their use in three different therapeutic applications. Challenges that must be overcome to derive clinical benefit from the application of nanotechnology to skin are discussed last, providing perspective on the significant opportunity that exists for future studies in investigative dermatology. PMID:22217738