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Sample records for apos apicectomia tratamento

  1. Evaluation of the permeability and morphological alteration of the dental surface after apicoectomy, treatment and preparation with Er:YAG and Nd:YAG lasers; Avaliacao da permeabilidade e da alteracao morfologica da superficie dentinaria apos apicectomia, tratamento e retropreparo com os lasers de Er:YAG e Nd:YAG

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Rodrigo Guerra de

    2001-07-01

    One of the objectives of endodontic treatment is to resolve pathological periapical processes caused by microbial contamination of the dental pulp. Correct execution of the necessary chemical preparation prior to surgery generally results in positive outcomes. However, a percentage of cases do not respond favorably and therefore require retreatment, a conservative therapeutic option. There are meanwhile a number of treatment failures which do not respond to these conservative measures and must therefore be subjected to paraendodontic surgical procedures. One of the principal problems of this therapeutic conduct is linked to the surface permeability of the dentin after apicoectomy and the lack of adequate marginal adaptation between the retrofilling material and the cavity walls. This permits the percolation of microorganisms and their metabolic by products from the system of root canals to the periapical region, thereby compromising the necessary tissue repair. The present work proposes the evaluation of the surface and marginal permeability of cut dentin after apicoectomy and treatment with Er:YAG and Nd:YAG lasers with fiber optics and then retrofilled with intermediate restorative material (IRM). A total of 24 single rooted teeth whose canals were endodontically treated were divided into 3 experimental groups: group I, whose apices were sectioned with an Er:YAG laser and the resulting cavity and the cut dental surface were irradiated with this laser via a 50/10 type fiber; in group II the apicoectomy was conducted with an Er:YAG laser and the resulting cavity and the cut surface were irradiated with a Nd:YAG laser; in group III, the samples were apicoectomized and the cavities were treated with a high speed bur (control group). Analysis of the infiltration of the dye methylene blue throughout the cut dental surface and the reconstruction demonstrated that the samples in the irradiated groups presented lower indices of infiltration than the control group. The Group I samples, meanwhile, did not present statistically significantly better results than the control group. Group II presented statistically significantly less infiltration than the other experimental groups. This result is compatible with the morphological and structural alterations evidenced by scanning electron microscopy: the group I samples (Er:YAG) presented clean, irregular surfaces with the presence of some cratering, without a smear layer and with the dental tubules exposed. The group II samples (Er:YAG and Nd:YAG) presented smoother, clean surfaces, without a smear layer, with fusion and resolidification of the dentin which sealed the dental tubules. Under the conditions of the study, apicoectomy with the Er:YAG laser followed by subsequent treatment of the cut surface and resulting cavity with a Nd:YAG laser, have shown as an option capable of reducing the permeability of the dentin to methylene blue dye. (author)

  2. Avaliação de técnica cirúrgica parendodôntica: apicectomia em 90º, retrocavitação com ultra-som e retrobturação com MTA = Evaluation of endodontics surgical technique: apical resection with a 90 o angle, ultrasonic preparation of root-end cavities and trioxide aggregate (MTA) filling

    OpenAIRE

    Pozza, Daniel Humberto

    2005-01-01

    Técnicas consagradas como apicectomia por broca em 45 graus, retrocavidade com broca de aço esférica e retrobturação com amálgama tem sido gradativamente substituídas por novas seqüências de procedimentos que aumentam os benefícios cirúrgico, melhorando o prognóstico clínico. A metodologia utilizada neste artigo encontra-se ambasada em revisão bibliográfica e aplicação laboratorial. Isto possibilitou identificar inúmeras vantagens no uso da apicectomia em 90 graus, retrocavidade com ultra-som...

  3. Avaliação de técnica cirúrgica parendodôntica: apicectomia em 90º, retrocavitação com ultra-som e retrobturação com MTA = Evaluation of endodontics surgical technique: apical resection with a 90 o angle, ultrasonic preparation of root-end cavities and trioxide aggregate (MTA filling

    Directory of Open Access Journals (Sweden)

    Pozza, Daniel Humberto

    2005-01-01

    Full Text Available Técnicas consagradas como apicectomia por broca em 45 graus, retrocavidade com broca de aço esférica e retrobturação com amálgama tem sido gradativamente substituídas por novas seqüências de procedimentos que aumentam os benefícios cirúrgico, melhorando o prognóstico clínico. A metodologia utilizada neste artigo encontra-se ambasada em revisão bibliográfica e aplicação laboratorial. Isto possibilitou identificar inúmeras vantagens no uso da apicectomia em 90 graus, retrocavidade com ultra-som e retrobturação com Odontology Mineral Trioxide Aggregate (MTA, nas cirurgias

  4. Changing trends in the treatment of Graves' disease with radioiodine: a 12-year experience in a university hospital; Mudancas evolutivas no tratamento da doenca de Graves com iodo radioativo: 12 anos de experiencia em um hospital universitario

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    Souza, Marcus Vinicius Leitao de [Instituto Estadual de Diabetes e Endocrinologia (IEDE), Rio de Janeiro, RJ (Brazil)], e-mail: marcusleitao@gmail.com; Souza, Honomar Ferreira de [Universidade Federal Fluminense (UFF), Niteroi, RJ (Brazil). Faculdade de Medicina. Dept. de Endocrinologia; Buescu, Alexandru; Vaisman, Mario [Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ (Brazil). Faculdade de Medicina. Dept. de Endocrinologia

    2009-03-15

    Objective: To evaluate the changes in clinical parameters and in the approach to patients submitted to radioiodine therapy for Graves' disease. Materials and methods: Dossiers of 226 patients submitted to radioiodine therapy for Graves' disease in the period between January 1990 and December 2001 were retrospectively evaluated. For the purposes of statistical analysis, the 12-year period was subdivided into three periods of 4 years, with a comparison of clinical and laboratory variables in these periods. Results: The authors have observed that the total number of patients referred for radioiodine therapy as well as the percentage of female patients presented a significant increase (from 62% to 86%; p = 0.005). The percentage of patients pretreated with methimazole before radioiodine therapy increased significantly (from 9.1% to 35.6%; p = 0.03). The mean radioiodine dose delivered has also presented a significant increase (from 7.6 mCi to 12.7 mCi; p = 0.000003) with a direct reflection on a higher percentage of patients cured one year after the radioiodine therapy (from 55.6% to 83.7%; p = 0.004). Conclusion: Radioiodine therapy has increasingly been accepted for treatment of patients with Graves' disease and the doses delivered have increased to achieve a permanent cure as well as a reduction of the chances of recurrence. (author)

  5. Tratamento do diabetes melito gestacional

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    Maganha Carlos Alberto

    2003-01-01

    Full Text Available Neste artigo, os autores analisam os mais recentes avanços no tratamento do diabetes gestacional, enfatizando pontos importantes na abordagem terapêutica: dieta, exercícios, controle glicêmico, utilização da insulina, assim como a utilização de hipoglicemiantes orais. O artigo traz propostas atuais para o tratamento do diabetes melito gestacional bem como ressaltar suas peculiaridades quanto patologia clínico-obstétrica.

  6. Analysis of dose in heterogeneity adjuvant radiotherapy after surgical treatment of cases of breast cancer; Analise da heterogeneidade de dose em radioterapia adjuvante apos tratamento cirurgico de casos de cancer de mama

    Energy Technology Data Exchange (ETDEWEB)

    Grechi, Bruna E.; Schwarz, Ana Paula, E-mail: anapaulaschwarz@yahoo.com.br [Centro Universitario Franciscano (UNIFRA), Santa Maria, RS (Brazil); Teston, Adriano; Rodrigues, Joanilso S. [Clinica de Radioterapia Santa Maria, Santa Maria, RS (Brazil)

    2013-12-15

    Assuming the systems planning radiotherapy recognize all body structures of the same density (d=1 g/cm³), variations in electron density within the irradiated area, as is the case of patients who undergo reconstruction mammary processes and use tissue expanders, may influence the dose distribution in the treatment and may produce heterogeneities which are not measured by changing its actual distribution into healthy tissues or in the target volume to be irradiated. Through the calculation of the algorithms' dose distribution of the XiO® planning system (Fast Fourier Transform, Convolution, Superposition, Fast Superposition e Clarkson), when using correction of heterogeneity between tissues of different densities, there was obtained a percentage ratio of dose increase in the structures of interest, and of the amount of absorbed dose by healthy organs adjacent to the target volume. (author)

  7. Tratamento da leishmaniose tegumentar americana pelo niridazol

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    Miroslau Constante Baranski

    1970-08-01

    Full Text Available Foi empregue o niridazol um derivado do nitrotiazol, em doze pacientes com leishmaniose tegumentar americana. Em todos êles, o diagnóstico clínico da doença foi confirmado pela biópsia das lesões e em oito dêles também pela positividade da intradetermorreação de Montenegro. Oito pacientes tinham lesões mucosas metastáticas em atividade e lesões cutâneas iniciais cicatrizadas há tempo mais ou menos longo. Dois apresentavam concomitância de lesões cutâneas e mucosas em atividade, e dois tinham lesões cutâneas exclusivas. A duração da doença variou de 2 meses a 32 anos. A posologia diária do niridazol foi uniformememente de 25 mg/kg de pêso corpóreo. O medicamento foi administrado por via oral, em duas tomadas diárias, sempre com o doente internado em hospital. Quando a tolerância o permitia, o paciente recebia cinco séries de tratamento de 10 dias de duração cada, intercaladas por períodos áe suspensão da droga de 10 dias entre uma série e outra. Isso foi possível em 10 dos 12 pacientes. O tratamento foi bem tolerado em 5 doentes e de tolerância regular em 4. Mal tolerado em um paciente pela ocorrência de alucinações e excitação mental e interrompido pela péssima tolerância em dois doentes devido ao aparecimento de convulsões generalizadas com perda da consciência. O tratamento acompanhou-se de grande incidência, de efeitos colaterais. A ocorrência de para-efeitos mais intensos não foi devida às más condições hepáticas. Provas de função hepática. hemogramas, estudos bioquímicos do sangue e exames de urina, realizados antes, durante e após o tratamento, não revelaram alterações significativas. Biópsias hepáticas por punção com agulha em dez doentes, prévias e posteriores ao tratamento, não detectaram lesões hepáticas que pudessem ser atribuídas à medicação. O seguimento dos doentes prolongou-se pelo prazo de dois a 36 meses apos o tratamento. Alterações eletrocardiogr

  8. Tegretol no tratamento da epilepsia

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    Jorge Armbrust-Figueiredo

    1968-09-01

    Full Text Available O Tegretol (5-carbamil-5H-dibenzo-b,L-azepina foi usado no tratamento de 68 pacientes com epilepsia; 54 apresentavam epilepsia temporal (42 com crises psicomotoras e 12 com crises complexas, 11 epilepsia focal de projeção não temporal e 3 epilepsia centrencefálica com crises P.M. Resultados satisfatórios foram observados em 82% dos 65 pacientes com epilepsia focal; os 3 pacientes com crises P.M. não foram influenciados pelo tratamento. A ação sobre as manifestações psíquicas que acompanhavam o quadro crítico ou intercrítico das crises ficou bem evidenciada. Os pacientes melhoraram de seus sintomas na grande maioria dos casos, conseguindo adaptar-se melhor no ambiente familiar, profissional e escolar. O efeito sobre as alterações eletrencefalográficas é moderado, e a evolução clínica não acompanha as modificações dos traçados. As doses usadas, em geral de 400 a 600 mg diários, são suficientes para o controle das crises na maioria dos casos e estão muito abaixo dos limites considerados como de segurança. As reações secundárias foram observadas em pequeno número de casos e foram sempre transitórias. O Tegretol representa, em nossa opinião, recurso de valor no trataemnto das epilepsias focais, particularmente nas crises psicomotoras.

  9. Tratamento da giardiase com tinidazol

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    Miroslau Constante Baranski

    1975-02-01

    Full Text Available Estudou-se a eficácia terapêutica do tinidazol, um novo derivado nitroimidazólico, em trinta pacientes com giardiase. A posologia diária foi de 300 mg em 20 pacientes com idade superior a 10 anos, e de 150 mg em 10 crianças com idade inferior a 10 anos. O tratamento teve a duração de cinco dias. O diagnóstico e os controles de cura parasitológicos foram feitos pelos métodos de Hoffman, Pons & Janer e de Faust e cols. Foram realizados três controles, com intervalos de sete dias, iniciando-se na semana subsequente ao término do tratamento. Obtiveram cura parasitológica em 96,6% dos casos. Ressaltam a excelente tolerância da droga, mesmo em pacientes com grave doença fundamental ou em crianças, não se registrando efeitos colaterais. Concluem ser o tinidazol excelente droga giardicida.The Autors study the therapeutic efficacy of Tinidazole, a new nitrimidazole derivative, in the treatment of thirty patients with giardiasis. They employed the daily dosage of 300 mg for twenty patients and 150 mg for ten children, respectively with ten years of age or and less during five consecutive days. The diagnosis and the parasitological evaluation of the results of treatment were accomplished by stool examinations using zinc sulphate centrifugal-flotation technique of Faust et al. and sedimentatian-concentration technique of Hoffman, Pons and Janer. The control started one week after the treatment and consisted of three stool examinations, at one week intervals. The Authors achieved 96.6 per cent of parasitological cures. They stressed the excellent tolerance of the drug ,even by patients with serious fundamental diseases or by children. No side effects were registered. They conclude that Tinidazole is an excellent drug against Giardia lamblia infections.

  10. Tratamento imunossupressor na esclerose múltipla

    OpenAIRE

    Oliveira, T. V.; A. M. Gorz-Reinhardt; C. M. Gracia; P.R.M. de Bittencourt

    1992-01-01

    Um estudo aberto, retrospectivo e não-controlado, foi realizado para avaliar a eficácia e tolerabilidade do tratamento imunossupressor instituído no período de 1982 a 1990 em pacientes com diagnóstico de esclerose múltipla clinicamente definida. Dos 42 pacientes, 18 (43%) foram tratados com uma só droga e 24 (57%) com mais de uma. A tolerabilidade foi avaliada após 6 meses de tratamento em 42 pacientes, dos quais 6 receberiam tratamento com prednisona, 26 com azatioprina, 17 com metilpredniso...

  11. Oil protection action ''Green Aalesund''; Oljevernaksjonen ''Green Aalesund''

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This report describes the actions taken after the refrigerator ship ''Green Aalesund'' ran aground north of Haugesund, Norway, on December 12, 2000. The report was worked out by the National State Pollution Control Authority (SFT). It is based on logs and other written documentation. The clean-up was carried out competently and successfully and the environmental damage was small.

  12. O psicanalista no tratamento da dor

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    Sueli Pinto Minatti

    2012-12-01

    Full Text Available A dor se manifesta como mal-estar do corpo e no corpo, e tende a ser encaminhada para tratamento médico. O objetivo deste trabalho é analisar a queixa dolorosa do ponto de vista do tratamento psicanalítico, retomando algumas acepções relacionadas ao tratamento da dor, encontradas na obra de Freud. Partimos da experiência no trabalho em hospital pediátrico, utilizando a análise do atendimento de pacientes com queixas de dor para definir e situar a dor no campo da psicanálise, e distingui-la do campo da medicina. No texto, pode-se acompanhar a dor como signo de sofrimento e diversas formas de abordá-la tanto pelo sujeito que a porta quanto pelas instituições que propõem seu cuidado.

  13. The strategic ''pull'' and operational ''push'' of total quality management in UK regional electricity service companies

    Energy Technology Data Exchange (ETDEWEB)

    McAdam, R.; McLean, J.; Henderson, J.

    2003-04-30

    The aim of this paper is to evaluate whether the UK regional electricity companies (RECs) has used total quality management (TQM) as a ''push'' or as a ''pull'' change methodology. ''Push'' is the operational improvement role of TQM; ''pull'' is the strategic or direction giving, improvement role of TQM. Following the onset of privatisation in 1990 there has been evidence of the RECs adopting TQM in both ''push'' and ''pull'' methodologies with varying degrees of success. An evaluation of the change processes involved will enable improved change models to be developed leading to increased business effectiveness in this 30 billion pounds sterling industry. Other possible benefits include the possible generalisations to other utilities such as water, roads, gas and telecoms. The research methodology includes a comparative case study analysis of five RECs, which have used TQM as their overarching approach to change. One of the cases is analysed to a more in-depth level based on the multiple case findings. The findings indicate that the ''push-pull'' analysis enables the full range of TQM activities to be evaluated in the RECs studied. Overall, there is a need to have a balanced portfolio of operational or ''push''-based TQM activity that is driven by strategic or ''pull'' based TQM planning and activity. (author)

  14. High energy X-ray laboratory ''HEXYLab''. The new facility ''HEXYTech''; Hochenergie-Roentgen-Labor ''HEXYLab''. Die neue Anlage ''HEXYTech''

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    Redmer, Bernhard; Hohendorf, Stefan; Kolkoori, Sanjeevareddy; Wrobel, Norma; Ewert, Uwe [BAM Bundesanstalt fuer Materialforschung und -pruefung, Berlin (Germany)

    2015-07-01

    High-energy radiography is used traditionally for the detection of defects in the thick-walled, bulky components. It is also used for testing the integrity of components for civil and security related applications (containers). The combination of high-energy emitters with digital detector arrays or line cameras allows test procedures in a shorter time compared to film or higher contrast sensitivity. The high-energy X-ray laboratory HEXYLab BAM is a joint laboratory in which future users, manufacturers and scientists can initiate and develop joint development projects. The new universal manipulation system HEXYTech forms the engineering and technical base for the most diverse requirements in HEXYLab (High Energy X-raY Lab.). With a total of 13 rotary and linear axes the diverse trajectories for tube, object and detector can be programmed. So large objects with complex geometries can be examined. 2D and 3D images can be measured by simple radiography, and laminography and computed tomography. The general rules for the application of high energy radiography with digital detectors (imaging plates, Digital detector arrays) were determined within the framework of the European project ''HEDRad'' (High Energy Digital Radiography) and included in the standard DIN EN ISO 17636-2. This article gives an overview of the testing technology and presents the possible applications on the basis of images and experiments. (PowerPoint slides). [German] Hochenergie-Radiographie wird traditionell fuer die Detektion von Defekten in dickwandigen, sperrigen Komponenten angewendet. Sie wird auch genutzt fuer die Pruefung der Komponentenintegritaet bei zivilen und sicherheitsrelevanten Anwendungen (Container). Die Kombination von Hochenergie- Strahlern mit digitalen Detektorarrays oder Zeilenkameras ermoeglicht die Pruefungsdurchfuehrung in kuerzerer Zeit im Vergleich zum Film oder mit hoeherer Kontrastempfindlichkeit. Das Hochenergie-Roentgen-Labor ''HEXYLab'&apos

  15. Custo comparativo do tratamento de feridas

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    Eline Lima Borges

    1999-06-01

    Full Text Available Este estudo compara o custo do curativo tradicional e o do preconizado pelo protocolo do setor de Estomaterapia do HC/UFMG no tratamento de diversos tipos de feridas. Ao final do trabalho, foi possível concluir que o custo do último é inferior ao do primeiro e que a freqüência na troca do curativo tradicional constitui fator de maior significância na elevação de seu custo.

  16. Oil protection ''John R''; Oljevernaksjon ''John R''

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The report briefly reviews the emergency actions after the bulk ship ''John R'' ran aground off Troms on December 15, 2002. The report was worked out by the contingency and control division at the National State Pollution Control Authority (SFT). SFT mobilized their own action organization to attend to the oil pollution preparedness around the disabled ship. The Norwegian Directorate of Shipping and Navigation (SD) mobilized in order to attend to a possible emergency discharging of the ship. In the opening phase, the situation was handled by Defence Command North Norway. The report is built on logs and other written documentation from the Coast Guard and from SFT. Material from several other participants are also included. The harmful effects on the environment were kept to a minimum. Altogether oil damage was observed on 1300 - 1800 sea birds. Only minor shores in three areas were affected.

  17. Microbiological, physicochemical and sensory evaluation of cabbage and carrot minimally processed salad after radiation treatment intended to immunocompromised patients or with special diets; Avaliacao microbiologica, fisico-quimica e sensorial de salada de repolho com cenoura minimamente processada apos o tratamento por radiacao gama destinado a pacientes imunocomprometidos ou com dietas especiais

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Thaise Cristine Fernandes

    2015-09-01

    During and after the treatment of cancer, people with HIV or transplants, the food intake can offer a well-being to the patient, because the action of eating right helps people to feel strong. Healthy people have their immune system working properly and can tolerate small amounts of bacteria. However, immunocompromised persons may not be able to and however immunocompromised people cannot fight this small amount of microorganisms and require a diet with very low microbiological count to avoid contact with potentially harmful bacteria. This is called neutropenic diet. These patients are susceptible to food contamination, so that it's not advisable the ingestion of raw products. The vegetable irradiation with low doses has the purpose of reducing the microbial load. The aim of this study was to obtain data on microbiological, sensorial e physicochemical aspects in minimally processed 'Primavera' salad irradiated with different doses of gamma radiation designed to immunocompromised patients. It were used doses of 1.0kGy, 2.0kGy, 3.0kGy and 4.0kGy irradiated in the Multipurpose Irradiator {sup 60}Co located in Radiation Technology Center. Microbiological analyzes were performed (n=25) using Petrifilm, sensory analysis using the sensory acceptance test (n=30) and triangular (n=15) and texture analysis (n=90) in the Food Microbiology Laboratory located at the Radiation Technology Center. The texture analysis was performed with the aid of a texturometer equipped with 5 kg load cell using a triangular cutting Warner-Bratzler Knife blade probe with the descent speed of 2mm/sec. All results were expressed in Newtons (N). The results showed that for microbiological analyzes the standards were followed according to the RDC 12/01 ANVISA. For the sensory test of acceptation no difference was found among the samples, however in the triangular test could be found slight differences between samples irradiated with 4.0kGy and control and there was significant

  18. a eficácia do tratamento

    OpenAIRE

    Fonseca, Tânia

    2011-01-01

    Trabalho apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Licenciada em Fisioterapia. Objectivo: O objectivo desta revisão sistemática é comprovar a relação entre a articulação têmporo-mandibular (ATM) e alterações posturais e ressaltar a importância e a eficácia do tratamento fisioterapêutico nas alterações posturais para melhora dos sintomas de disfunção temporomandibular (DTM). Metodologia: pesquisa de estudos datados entre 2000 e...

  19. prevenção e tratamento

    OpenAIRE

    Tambelli, Bianca

    2013-01-01

    Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária O desenvolvimento de lesões de mancha branca em indivíduos submetidos ao tratamento ortodôntico com aparatologia fixa constitui um problema clínico importante. A inadequada higiene oral cria condições adicionais propícias ao aumento significativo da placa bacteriana ao redor dos suportes dos aparelhos fixos, fator este responsável pe...

  20. Country report: Lithuania. ''Best practice'' projects and measures in Lithuania

    Energy Technology Data Exchange (ETDEWEB)

    Kazakevicius, E. [Housing and Urban Development Foundation (Lithuania); Jarasunas, V. [Energy Efficiency Center (Lithuania); Skema, R. [Lithuanian Energy Inst. (Lithuania)

    2002-11-01

    The authors report on selected ''best practice'' energy efficiency and renewable energy projects and measures in Lithuania: thermal energy conservation in the building sector, energy audits in industry, biomass utilization. (uke)

  1. The ''invisible'' radioactive scale

    Energy Technology Data Exchange (ETDEWEB)

    Bjoernstad, T.; Ramsoey, T

    1999-04-01

    Production and up-concentration of naturally occurring radioactive material (NORM) in the petroleum industry has attracted steadily increasing attention during the last 15 years. Most production engineers today associate this radioactivity with precipitates (scales) and sludges in production tubing, pumps, valves, separators, settling tanks etc., wherever water is being transported or treated. {sup 226}Ra and {sup 228}Ra are the most well known radioactive constituents in scale. Surprisingly little known is the radioactive contamination by {sup 210}Pb and progeny {sup 210}Bi and {sup 210}Po. These are found in combination with {sup 226}Ra in ordinary scale, often in layer of non-radioactive metallic lead in water transportation systems, but also in pure gas and condensate handling systems ''unsupported'' by {sup 226}Ra, but due to transportation and decay of the noble gas {sup 222}Rn in NG/LNG. This latter contamination may be rather thin, in some cases virtually invisible. When, in addition, the radiation energies are low enough for not being detectable on the equipment outer surface, its existence has for most people in the industry been a secret. The report discusses transportation and deposition mechanisms, detection methods and provides some examples of measured results from the North Sea on equipment sent for maintenance. It is concluded that a regular measurement program for this type of contamination should be mandatory under all dismantling processes of transportation and fluid handling equipment for fluids and gases offshore and onshore.

  2. Lufenuron no tratamento da dermatofitose em gatos?

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    Regina R. Ramadinha

    2010-02-01

    Full Text Available Em função de controvérsias sobre a eficácia do lufenuron no tratamento da dermatofitose causada por Microsporum canis, o efeito da droga foi avaliado em 46 gatos (30 com lesões cutâneas e 16 portadores assintomáticos atendidos no Hospital Veterinário da Universidade Federal Rural do Rio de Janeiro, Brasil. O diagnóstico foi estabelecido através da lâmpada de Wood, da cultura fúngica e, adicionalmente, na maioria dos animais sintomáticos, pela avaliação histopatológica da pele. Os animais foram tratados com 120mg/kg de lufenuron, a cada 21 dias (quatro doses; a droga mostrou-se eficaz no tratamento de 29 dos 30 felinos que apresentaram a forma clínica da dermatofitose, bem como no de todos os animais assintomáticos. O único felino que não teve cura clínica completa havia recebido várias doses de dexametasona antes do inicio do tratamento. Em um animal gestante, foram utilizadas duas doses do lufenuron e não foi observada qualquer alteração clínica e morfológica nos filhotes. Nenhum dos animais tratados teve qualquer reação adversa ao medicamento. Vinte dias após o último tratamento, o exame micológico resultou negativo em 45 dos felinos estudados (98%. Embora o lufenuron tenha o custo um pouco mais elevado do que o do cetoconazol, é uma droga que apresenta praticidade e margem de segurança bem maiores. Vale ressaltar que o sucesso do tratamento está diretamente relacionado à correta utilização da droga, assim como a perfeita higienização do ambiente e dos utensílios dos animais.Due to discrepancies regarding the effectiveness of lufenuron in treating dermato-phytosis caused by Microsporum canis the effect of this drug was checked in 46 cats (30 with cutaneous lesions and 16 asymptomatic carriers treated in the Veterinary Hospital of the Federal Rural University of Rio de Janeiro, Brazil. The diagnosis was based on Wood's lamp examination and fungal cultures. Biopsies were only performed in symptomatic

  3. Development and deployment of a novel ''yellow'' demulsifier for the gullfaks ''A'' platform

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, S.J.; Ingebrigtsen, T.; Breen, P.J.; Waage, J.; Thorstenson, T.; Melby, S.

    2006-03-15

    Oil producers are increasingly under pressure to produce their product in an environmentally sound manner. Releases to the environment are undesirable and, where permitted to make such releases, oil producers should minimise their environmental impact. The bulk of treatment chemicals designed to improve separation and provide clean water for disposal can themselves be harmful to the environment and must conform to very stringent rules to be considered environmentally acceptable, or ''green''. Here we present data on the development of a green demulsifier for Statoil's Gullfaks ''A'' platform, which not only meets the very stringent regulations but also exhibits a significant improvement in product performance. While the''bottle test'' remains the industry standard method for selecting demulsifiers, in recent years the ''mini trial'' method for product selection has gained favour. We describe using a combination of both methods for the development of the novel demulsifier technology described here. (Author) (tk)

  4. Adesão ao tratamento da ambliopia

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    Arakaki Mara Regina

    2004-01-01

    Full Text Available OBJETIVO: Avaliar a influência da adesão no resultado do tratamento da ambliopia. MÉTODOS: Foi feito estudo retrospectivo avaliando a resposta ao tratamento da ambliopia em 151 crianças portadoras de ambliopia, tratadas com esquema de oclusão diária, com o número de dias variando de acordo com a idade da criança. Os pacientes foram separados em dois grupos que diferiam entre si pela adesão ou não ao tratamento. RESULTADOS: Observou-se que o tratamento teve melhores resultados nas crianças de 4 a 7 anos e que aderiram ao tratamento; as crianças que aderiram ao tratamento necessitaram de tempo menor de permanência em tratamento. Mesmo crianças com idade superior a 7 anos tiveram resultados positivos com a oclusão. CONCLUSÃO:O tratamento oclusivo é um meio terapêutico eficiente desde que haja a cooperação do paciente.

  5. 'Side-by-side'

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2010-07-01

    France is a nuclear power nation. And this is not going to change. However, at the same time, the country is also pursuing massive investments in the expansion of renewable energies. According to France's President Nicolas Sarkozy, the motto should be: 'side-by-side' rather than 'one or the other'. For the PV sector, whose success was unbroken during the crisis in 2009, the signal is positive and could mean sustained growth. (orig.)

  6. prevenção e tratamento

    OpenAIRE

    Sousa, Andreia Margarida Ferreira de

    2011-01-01

    Sensação retardada de dor muscular (SRDM) é uma lesão por esforço muscular que se desenvolve após o exercício excêntrico, mas a eficácia do tratamento de fisioterapia ainda não foi sistematicamente avaliado. Esta revisão sistemática teve como objectivo reunir informação sobre as medidas de prevenção e/ou as medidas terapêuticas sobre os efeitos de SRDM. Após a pesquisa computorizada em bases de dados electrónica foram incluídos 17 artigos (exercício concêntrico, n=3; alongament...

  7. Tratamento da depressão

    Directory of Open Access Journals (Sweden)

    Fábio Gomes de Matos e Souza

    1999-05-01

    Full Text Available O tratamento antidepressivo deve ser realizado considerando os aspectos biológicos, psicológicos e sociais do paciente. Na média, não há diferenças significativas em termos de eficácia entre os diferentes antidepressivos mas o perfil em termos de efeitos colaterais, preço, risco de suicídio, tolerabilidade varia bastante o que implica em diferenças na efetividade das drogas para cada paciente. A conduta, portanto, deve ser individualizada. A prescrição profilática de antidepressivos irá depender da intensidade e freqüência dos episódios depressivos. O risco de suicídio dever ser sempre avaliado e se necessário o ECT deverá ser indicado. Não há antidepressivo ideal, entretanto, atualmente existe uma disponibilidade grande de drogas atuando através de diferentes mecanismos de ação o que permite que, mesmo em depressões consideradas resistentes, o tratamento possa obter êxito.The antidepressant treatment should be accomplished considering the patient’s biological, psychological and social aspects. In average, there are no significant differences in terms of efficacy among the different antidepressants but the profile in terms of collateral effects, price, suicide risk, tolerability shows great variation which implies in differences in the effectiveness of drugs for each patient. The therapy, therefore, should be individualized. The prophylactic prescription of antidepressants will depend on the intensity and frequency of the depressive episodes. The suicide risk should always be evaluated and if necessary ECT should be prescribed. There is no ideal antidepressant, however, there is a large variety of drugs acting through different mechanisms of action which allows the possibility of therapeutic success in resistant depressions.

  8. HEMOFILIAS: FISIOPATOLOGIA, DIAGNÓSTICO E TRATAMENTO

    Directory of Open Access Journals (Sweden)

    Roberta Truzzi COLOMBO, Gerson ZANUSSO JÚNIOR

    2013-12-01

    Full Text Available A hemofilia é um grave distúrbio hereditário da coagulação sanguínea, causada pela deficiência da atividade coagulante do fator VIII (hemofilia A ou IX (hemofilia B. A doença é decorrente de alterações nos genes codificantes destes fatores localizados no braço longo do cromossomo sexual X. Assim sua ocorrência no sexo masculino é quase que exclusiva, devido o homem apresentar somente um cromossomo X. A gravidade da doença pode variar em severa, moderadamente severa e leve, após dosagem dos fatores VIII e IX da coagulação. Uma das complicações mais temíveis dos pacientes com esta doença refere-se ao desenvolvimento de inibidores, que são anticorpos direcionados contra os fatores infundidos. O diagnóstico da doença é realizado através de exames laboratoriais, principalmente pelo coagulograma completo e dosagem de fatores específicos, baseando-se nas manifestações clínicas apresentadas pelo paciente. A hemofilia não tem cura e a base do seu tratamento é a infusão do concentrado do fator deficiente. No entanto, pacientes podem desenvolver inibidores específicos para os fatores infundidos e, nestes casos as alternativas de tratamento são o uso da biotecnologia para novos medicamentos e o uso da terapia gênica

  9. BLOWIN' IN THE WIND: BOTH ''NEGATIVE'' AND ''POSITIVE'' FEEDBACK IN AN OBSCURED HIGH-z QUASAR

    Energy Technology Data Exchange (ETDEWEB)

    Cresci, G.; Mannucci, F. [INAF-Osservatorio Astrofisco di Arcetri, largo E. Fermi 5, I-50127, Firenze (Italy); Mainieri, V. [European Southern Observatory, Karl-Schwarzschild-strasse 2, D-85748 Garching bei München (Germany); Brusa, M.; Perna, M.; Lanzuisi, G. [Dipartimento di Fisica e Astronomia, Università di Bologna, viale Berti Pichat 6/2, I-40127 Bologna (Italy); Marconi, A. [Dipartimento di Fisica e Astronomia, Università degli Studi di Firenze, via G. Sansone 1, I-50019 Sesto F.no, Firenze (Italy); Piconcelli, E.; Feruglio, C.; Fiore, F.; Bongiorno, A. [INAF-Osservatorio Astronomico di Roma, via Frascati 33, I-00040 Monteporzio Catone (Italy); Maiolino, R. [Cavendish Laboratory, University of Cambridge, 19 J. J. Thomson Avenue, Cambridge (United Kingdom); Merloni, A [Max Planck Institut für Extraterrestrische Physik, Giessenbachstrasse 1, D-85748 Garching bei München (Germany); Schramm, M.; Silverman, J. D. [Kavli Institute for the Physics and Mathematics of the Universe (WPI), Todai Institutes for Advanced Study, the University of Tokyo, Kashiwanoha 5-1-5, Kashiwa-shi, Chiba 277-8568 (Japan); Civano, F., E-mail: gcresci@arcetri.astro.it [Department of Physics and Yale Center for Astronomy and Astrophysics, Yale University, PO Box 208121, New Haven, CT 06520-8121 (United States)

    2015-01-20

    Quasar feedback in the form of powerful outflows is invoked as a key mechanism to quench star formation in galaxies, preventing massive galaxies to overgrow and producing the red colors of ellipticals. On the other hand, some models are also requiring ''positive'' active galactic nucleus feedback, inducing star formation in the host galaxy through enhanced gas pressure in the interstellar medium. However, finding observational evidence of the effects of both types of feedback is still one of the main challenges of extragalactic astronomy, as few observations of energetic and extended radiatively driven winds are available. Here we present SINFONI near infrared integral field spectroscopy of XID2028, an obscured, radio-quiet z = 1.59 QSO detected in the XMM-COSMOS survey, in which we clearly resolve a fast (1500 km s{sup –1}) and extended (up to 13 kpc from the black hole) outflow in the [O III] lines emitting gas, whose large velocity and outflow rate are not sustainable by star formation only. The narrow component of Hα emission and the rest frame U-band flux from Hubble Space Telescope/Advanced Camera for Surveys imaging enable to map the current star formation in the host galaxy: both tracers independently show that the outflow position lies in the center of an empty cavity surrounded by star forming regions on its edge. The outflow is therefore removing the gas from the host galaxy (''negative feedback''), but also triggering star formation by outflow induced pressure at the edges (''positive feedback''). XID2028 represents the first example of a host galaxy showing both types of feedback simultaneously at work.

  10. ApoE polymorphisms in narcolepsy

    Directory of Open Access Journals (Sweden)

    Kasten Meike

    2001-08-01

    Full Text Available Summary Background Narcolepsy is a common neuropsychiatric disorder characterized by increased daytime sleepiness, cataplexy and hypnagogic hallucinations. Deficiency of the hypocretin neurotransmitter system was shown to be involved in the pathogenesis of narcolepsy in animals and men. There are several hints that neurodegeneration of hypocretin producing neurons in the hypothalamus is the pathological correlate of narcolepsy. The ApoE4 allele is a major contributing factor to early-onset neuronal degeneration in Alzheimer disease and other neurodegenerative diseases as well. Methods To clarify whether the ApoE4 phenotype predisposes to narcolepsy or associates with an earlier disease onset, we have genotyped the ApoE gene in 103 patients with narcolepsy and 101 healthy controls. Results The frequency of the E4 allele of the ApoE gene was 11% in the patient and 15% in the control groups. Furthermore, the mean age of onset did not differ between the ApoE4+ and ApoE4- patient groups. Conclusion Our results exclude the ApoE4 allele as a major risk factor for narcolepsy.

  11. Korea's 1-watt plan ''Standby Korea 2010''

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Yungrae

    2010-09-15

    Korea announced standby power of all electronics shall be reduced to below 1W by 2010. Ministry of Knowledge Economy (MKE, Korean government) and Korea Energy Management Corporation (KEMCO) established ''Standby Korea 2010'' which is a roadmap to limit standby power below 1W by 2010. Korea implemented mandatory program over a relatively short period of time, incorporating the better elements from the more established national program and adding new initiatives, such as the threat of using mandatory warning label for products that fail to meet standby power targets.

  12. ''When Cost Measures Contradict''

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P. M.

    2003-05-09

    When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy's costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure's ability to correctly rank policies from most beneficial to most harmful. This paper analyzes empirically these two properties of different costs measures as they pertain to assessing the costs of the carbon abatement policies, especially the Kyoto Protocol, under alternative assumptions about implementation.

  13. Tratamento de leucemia linfóide aguda e crescimento

    OpenAIRE

    Monteiro I.M.U.; Bedone A.J.; Pinto C.L.B.; Brandalise S.R.

    1998-01-01

    OBJETIVO: Determinar alterações no crescimento após o tratamento de leucemia linfóide aguda em meninas. PACIENTES E MÉTODO: Realizou-se estudo retrospectivo com 59 meninas que apresentavam medidas de estatura antes e com no mínimo um ano do tratamento, subdivididas de acordo com a dose de radioterapia cranial utilizada [18 ou 24 Grays (Gy)] e com a idade no início do tratamento (antes e após os cinco anos de idade). RESULTADOS: Observou-se deficiência do crescimento com um, dois e mais de doi...

  14. Software in the DOE: The Hidden Overhead of''The Build''

    Energy Technology Data Exchange (ETDEWEB)

    Kumfert, G; Epperly, T

    2002-02-28

    ''The Build'' is the infrastructure needed to convert software from source code to usable form. It is intimately tied to the software it supports, knowing about every file and automating every transformation needed to produce a working program. Every developer knows that a project spends some labor overhead on ''the build.'' How big is this hidden overhead? According to 34 scientific software developers we surveyed at Lawrence Livermore National Labs, among colleagues at other DOE labs, and a handful of academics the ''perceived'' overhead averages around 12%. Individual cases of 20% to 30% were not uncommon. In one project claiming a 20% overhead, we found supporting evidence by combing through their CVS repository.

  15. Dietilcarbamazina no tratamento da filariose bancroftiana

    Directory of Open Access Journals (Sweden)

    Gerusa Dreyer

    1997-06-01

    Full Text Available Os autores realizaram uma ampla revisão sobre o tratamento da filariose bancroftiana com a droga dietilcarbamazina. Os aspectos interessantes sobre o histórico de sua descoberta e os conceitos básicos de sua farmacologia foram relatados de forma resumida. Ênfase especial, por outro lado, foi dada às especulações feitas pelos diversos autores sobre os achados intrigantes descritos na literatura. Foram trazidos os novos avanços sobre o conhecimento da doença, como por exemplo, a visualização pela ultra-sonografia do verme vivo de Wuchereria bancrofti, no seu hospedeiro natural, o homem. Isso possibilitou a compreensão de muitos dos achados aparentemente paradoxais encontrados na literatura sobre o tratamento da infeção com a DEC. Assim, devido à inexistência de uma droga sucessora que reunisse efeitos micro e macrofilaricidas ideais e aos novos conhecimentos sobre a bancroftose e sobre a própria dietilcarbamazina, foi-lhe conferido um novo realce. Esses aspectos a colocaram numa posição de destaque no cenário da infecção, à época do seu quase cinqüentenário de existência.The authors presented a detailed review about the tratment of bancroftian filariasis with diethylcarbamazine. The interesting aspects about the drug discovery and the basic concepts about its pharmacology were reported in a summarised form. On the other hand, emphasis was made about the speculation done by several authors about the intringuing findings regarding its efficacy reported in the literature. Latter, it was brought the new advances about the disease, as for example, the visualization by ultrasound of living Wuchereria bancrofti adult worm on its natural host3/4the human being. This made possible the comprehension of several paradoxical issues reported, focusing the treatment of infection using diethylcarbamazine. So far, because of the lack of ideal drug with micro and macrofilaricidal properties, together with the new understand about the

  16. A ''LIGHT'', CENTRALLY CONCENTRATED MILKY WAY HALO?

    Energy Technology Data Exchange (ETDEWEB)

    Rashkov, Valery; Pillepich, Annalisa; Deason, Alis J.; Madau, Piero [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Rockosi, Constance M. [Department of Astronomy and Astrophysics, UCO/Lock Observatory, University of California, Santa Cruz, CA 95064 (United States); Guedes, Javiera [Institute for Astronomy, ETH Zurich, 8093 Zurich (Switzerland); Mayer, Lucio [Institute of Theoretical Physics, University of Zurich, CH-9057 Zurich (Switzerland)

    2013-08-20

    We discuss a novel approach to ''weighing'' the Milky Way (MW) dark matter halo, one that combines the latest samples of halo stars selected from the Sloan Digital Sky Survey (SDSS) with state of the art numerical simulations of MW analogs. The fully cosmological runs employed in the present study include ''Eris'', one of the highest resolution hydrodynamical simulations of the formation of a M{sub vir} = 8 Multiplication-Sign 10{sup 11} M{sub Sun} late-type spiral, and the dark-matter-only M{sub vir} = 1.7 Multiplication-Sign 10{sup 12} M{sub Sun} ''Via Lactea II'' (VLII) simulation. Eris provides an excellent laboratory for creating mock SDSS samples of tracer halo stars, and we successfully compare their density, velocity anisotropy, and radial velocity dispersion profiles with the observational data. Most mock SDSS realizations show the same ''cold veil'' recently observed in the distant stellar halo of the MW, with tracers as cold as {sigma}{sub los} Almost-Equal-To 50 km s{sup -1} between 100 and 150 kpc. Controlled experiments based on the integration of the spherical Jeans equation as well as a particle tagging technique applied to VLII show that a ''heavy'' M{sub vir} Almost-Equal-To 2 Multiplication-Sign 10{sup 12} M{sub Sun} realistic host produces a poor fit to the kinematic SDSS data. We argue that these results offer added evidence for a ''light'', centrally concentrated MW halo.

  17. AREVA ''Sustainable Cycle Solutions''

    International Nuclear Information System (INIS)

    Almost three years after the Fukushima events, the nuclear industry has shown its capacity to respond to first additional safety requirements and continues working closely with the regulators and involved stakeholders for further improvements. Continued growth is still anticipated and several international organizations have confirmed 2035 scenarios close to or above 600 GWe of installed nuclear capacity. Securing and optimizing the fuel cycle is crucial to ensure the sustainability of such a nuclear program in the medium term. Rethinking fuel cycle schemes is also decisive to prepare long term transitions to next generations of reactors. R&D and Innovation shall remain a cornerstone of this sustainable development. Countries with significant or growing nuclear fleets have confirmed their commitment or plans to recycle. This is notably the case in China, France, India, Japan, the Netherlands, South Korea, and the Russian federation. Most of other nuclear countries are currently rethinking their used fuel management, taking into account; the geopolitical context and the international framework, including multilateral agreements, the legacy of their past fuel cycle policies,the cornerstones of energy policies' evolution such as the targets set for energy independence, as well as the level of their ambition in terms of nuclear park evolution, the involvement of concerned stakeholders in the decision making process, the regulatory and legal frameworks evolutions, the operational challenges that the nuclear actors are currently facing, in particular the increasing Constraints related to reactor pool storage, or to very long term dry storage. With the foreseen nuclear development, the used fuel backlog will continue to grow for several decades. Bolstered by a 40 years experience, recycling has been contributing to further increase safety while offering main operational, environmental, global acceptance benefits, among others However even though recycling

  18. Rapporteurs' Report

    Energy Technology Data Exchange (ETDEWEB)

    Isaacs, T H

    2004-02-11

    This Third FSC workshop focused on, ''Understanding the factors that influence public perception and confidence in the area of radioactive waste management...'' The workshop was held in Finland in close cooperation with Finnish stakeholders. This was most appropriate because of the recent successes in achieving positive decisions at the municipal, governmental, and Parliamentary levels, allowing the Finnish high-level radioactive waste repository program to proceed, including the identification of a proposed site. The workshop objective was to gain insight in answering the question, ''How did this political and societal decision come about?''

  19. Science closes in on the ''Holy Grail'' of solar energy

    Energy Technology Data Exchange (ETDEWEB)

    One of nature's best kept secrets ''how green plants and algae turn sunlight into useful energy'' is discussed. The work of Arizona State University chemists Devens Gust and Thomas Moore in the area of photosynthesis is described. The ultimate photochemical battery may be years away, but it was only seven years ago that these two scientists began working on a model that will someday make it possible.

  20. X-ray fluorescence analysis of the Venus rocks by the ''Venera-13' and ''Venera-14'' space probes

    Energy Technology Data Exchange (ETDEWEB)

    Surkov, Yu.A.; Shcheglov, O.P.; Moskaleva, L.P.; Kirichenko, V.S.; Dudin, A.D.; Gimadov, V.L.; Kurochkin, S.S.; Rasputnyj, V.N. (AN SSSR, Moscow. Inst. Geokhimii i Analiticheskoj Khimii)

    1982-08-01

    The device and X-ray measurement technique, used for the elemental analysis of Venerus' rocks by the ''Venera-13'' and ''Venera-14'' space probes, are described. The X-ray fluorescence spectrometer device, characteristics of Fe/sup 55/ and Pu/sup 238/ radioisotope sources, used in the device, the proportional counter and the structural flowsheet of the pulse amplitude analyzer, is briefly represented. Venerus' rock is sampled by a special coring tool, transported through the sluice port into the lander and irradiated by radioisotope sources. The excited fluorescence is recorded by a 256-channel spectrometer. The information is transmitted to the Earth telemetrically. The devices of both landers operate reliably. The chemical composition of the rock samples is determined as a result of these experiments.

  1. ''Social capitalism'' in renewable energy generation: China and California comparisons

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Woodrow W. II.; Li, Xing [Clark Strategic Partners, PO Box 17975, Beverly Hills, CA 90210 (United States)

    2010-03-15

    With a population of over 1.3 billion people, demand for renewable energy is expected to grow to a USD $12 billion market in the near term. Under Renewable Energy Law (REL) in February 2005 in the People's Republic of China (PRC) passed by the National Congress, renewable energy projects will be able to receive a range of financial incentives starting in 2006, which will more than double the PRC current renewable energy generation from 7% to 15% by 2020. Most of the increase will be in hydroelectric generated power. Nonetheless, the nation and especially the provinces are moving rapidly to develop a wide range of renewable energy generation including solar, wind, geothermal and run of the river. Because China practices ''social capitalism'' as expressed in it's recurrent Five Year National Plans since 1999, the national government and all the provinces have programs, unlike many western and industrialized nations, to ''plan'' and provide for infrastructures. This paper concerns only the energy infrastructure sector and renewable energy generation in particular. The planning process includes financial incentives and investments which are a major part of the Chinese law focused on ''encouraging foreign investment industries''. The key part of the law is to guarantee long-term power purchase agreements with state owned and controlled ''utilities''. In short, China may have gotten the economics of the energy sector correct in its concern for planning and finance. The paper develops these energy infrastructure ideas along with the legal and financial requirements as ''lessons'' learned from the USA and especially California. These lessons now apply to China and allow it to learn from the American mistakes. Empirical data will be drawn from work done in China that examine the renewable energy generation and infrastructures and hence allow the RPC and its

  2. Utilization of demolished composition materials of ''ClimateHouses''; Verwertung des Abbruchmaterials von ''KlimaHaeusern''

    Energy Technology Data Exchange (ETDEWEB)

    Knappe, Florian; Diebel, Anton; Reinhardt, Joachim; Theis, Stefanie [ifeu-Institut fuer Energie- und Umweltforschung GmbH, Heidelberg (Germany); Leiter, Elisabeth; Rosanelli, Rupert; Vieider, Andreas [Syneco, Bolzano (Italy); Feess, Walter [Firma Feess Erdbau, Kirchheim/Teck (Germany); Bonadio, Martina

    2012-09-15

    In the year 1992, an innovative concept of energy conservation was developed in order to improve the energy standards of new buildings as well as existing buildings. The model 'ClimateHouse' has to reduce significantly the energy demand in the area of needs building and living as well as the use of fossil resources and negative impacts on the climate. First of all the authors of the contribution under consideration report on and balance the situation in the province South Tyrol with respect to the design of 'ClimateHouses' and the use of construction materials for 'ClimateHouses'. This also is valid for solar panels. Within a second step the authors report on how the waste management has to be arranged to other waste mass flows and waste compositions.

  3. Report of working committee 4 ''transmission of gases''; Rapport de la commission 4 ''transport des gaz''

    Energy Technology Data Exchange (ETDEWEB)

    Volskij, E.

    2000-07-01

    Report of the WOC 4 Transmission contains the results of works carried out during 1998-2000 by the Committee members and the three study groups. The most important is: - review of actual situation and prospects for the gas pipeline transmission system development; - report of SG-4.1 'Pipeline Ageing and Rehabilitation', including analysis of pipeline steels, welding and insulation, methods of rehabilitation, the program of pipeline reconstruction; - report of SG-4.2 'Emission monitoring' including appraisal of gas losses and methods of lowering of methane and other emissions of the gas units in different countries; - report of SG-4.3 'Pipelines Integrity Management and Safety' including basic information on gas pipeline failure intensity, key elements of the Integrity Management System of the gas transmission, methods of risk evaluation and the effectiveness of the approach. (authors)

  4. ''Substantial Margin of Safety'': A New Approach to HLW Disposition

    Energy Technology Data Exchange (ETDEWEB)

    Power, M. S.

    2002-02-28

    In the Spring of 2001, the National Research Council published ''Disposition of High-Level Waste and Spent Nuclear Fuel: The Continuing Societal and Technical Challenges.'' (1) While finding the technical case for deep geologic disposal of high-level waste and spent fuel robust, the report focused new attention on societal issues and decision-making. The report appeared against a backdrop of heightened controversy about the development of a geologic repository at Yucca Mountain, Nevada. This paper identifies three principal reasons for the National Research Council committee's finding that ''Difficulties in achieving public support have been seriously underestimated in the past, and opportunities to gain public trust have been missed.''

  5. Carcinoma hepatocelular: parte 2. Tratamento Hepatocelular carcinoma: part 2. Therapy

    OpenAIRE

    CONTE Vinício Paride

    2000-01-01

    São revisadas as formas de tratamento, particularmente as ressecções cirúrgicas, a quimioembolização arterial e as injeções percutâneas de etanol e de ácido acético. Alguns aspectos relativos à dieta, com particular atenção à aflatoxina B1 e aos retinóides, são abordados quanto ao seu desempenho na etiopatogenia e no tratamento da afecção mais comumente encontrada nos países em desenvolvimento. Em relação ao tratamento, fazem-se considerações também referentes ao uso de octreotide, nitrosamin...

  6. Tratamento da anemia ferropriva com ferro por via oral

    Directory of Open Access Journals (Sweden)

    Rodolfo D. Cançado

    2010-06-01

    Full Text Available A anemia ferropriva permanece como uma das deficiências nutricionais mais frequentes e importantes no mundo. O tratamento com ferro deve ser iniciado preferencialmente por via oral e a investigação apropriada de sua causa é obrigatória. Os autores discutem os compostos com ferro atualmente disponíveis, o perfil de eficácia, segurança e tolerabilidade desses medicamentos, e o plano terapêutico mais adequado possível para o sucesso no tratamento dessa doença tão comum e importante.

  7. Tratamento nutricional dos transtornos alimentares Nutritional treatment of eating disorders

    OpenAIRE

    Andréa Romero Latterza; Karin Louise Lenz Dunker; Fernanda Baeza Scagliusi; Elisa Kemen

    2004-01-01

    Pacientes com transtornos alimentares possuem inadequações profundas no consumo, padrão e comportamento alimentar, além de diversas crenças equivocadas sobre alimentação, o que geralmente acarreta piora do estado nutricional. O tratamento nutricional visa a reverter tais alterações e promover hábitos alimentares saudáveis e melhor relação para com o alimento. Os objetivos e características do tratamento diferem para a anorexia nervosa e a bulimia nervosa, contudo, usualmente, a abordagem é di...

  8. 'et' special: ''E-world of energy''; 'et'-special: ''E-world of energy''

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2001-02-01

    The 'et' special on the conference 'E-world of energy', held from February 13 - 15, 2001 in Essen (Germany) presents contributions of experts who offer solutions to issues and many topical questions arising in the business of traders and utilities as participants of (international) energy markets at various stages of transition towards workable competition. The translated titles of the 15 contributions reproduced in this 'et' special indicate the major contents of the conference papers: 1. Internet-based wholesale power trading as a competitive option to the power exchange. 2. Forward graphs in European electricity markets. 3. Portfolio management in energy trading. 4. Risk management concepts in energy trading. 5. E-commerce as a driving force of a change in the energy markets. 6. eHuman resources management - a vital aspect of corporate success. 7. A brand policy for electricity? 8. Is it really only the price that counts for the customers? 9. The City Power network: an example of successful customer loyalty strategy for local and regional utilities. 10. The Call Center, an important instrument for customer loyalty programmes. 11. eCommerce or eLlusion? 12. eBusiness as a corporate strategy. 13. Meeting the challenges of increasing IT requirements. 14. IT solutions for transmission and distribution network management. 15. Target costing - pinpointed cost planning and control for the energy supply industry. (orig./CB) [German] In dem 'et'-Special zur Konferenz 'E-world of energy', die vom 13.- 15. Februar 2001 in Essen stattfand, bieten Experten Loesungsvorschlaege fuer die aktuellen Fragen und Probleme an, die sich auf dem Weg zu liberalisierten Energiemaerkten stellen. Die folgenden Titel der 15 Beitraege geben eine Uebersicht ueber den Inhalt der Konferenzbeitraege. Themen: 1. Internetbasierte Grosshandelsmaerkte als Konkurrenz zu Energieboersen 2. Forward-Kurven in europaeischen Strommaerkten 3

  9. Safety of the ''man-machine-environment'' system during well drilling

    Energy Technology Data Exchange (ETDEWEB)

    Fedorenko, V.I.; Fedorov, V.A.; Loginovskiy, V.I.; Nugayev, R.Ya.

    1982-01-01

    A review is given of safety of the oil and gas well drilling process, which depends on the correspondence and organization of the interaction of all components of the ''man-machine-environment'' system. The reasons for accidents, dangerous situations and emergencies are analyzed. An examination is made of the ergonomic characteristics of the system, questions of the study and development of ergonomic requirements for work site design at a drilling rig, and possible ways of improving these indices. Certain equipment is described that ensures safety of the ''man-machine-environment'' system during well drilling, improves the microclimatic working conditions, and eliminates shortcomings in equipment design.

  10. Cloning and Expression of Apolipoprotein E3 and Its Variant apoE2 and apoE4

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    In order to obtain three isoforms of apolipoprotein E (apoE), the cDNA encoding apoE3 was obtained by RT-PCR from normal human liver tissue. Site-directed mutagenesis was used to obtain the cDNAs encoding apoE2 and apoE4 isoforms. The 3 cDNAs were subcloned into vector pGEM-3Z and verified by DNA sequencing. The expression recombinant which can express the target protein as a (His) 6-tagged fusion was constructed by subcloning apoE cDNA into vector pT7-PL. The purified proteins were gained by Ni-NTA column. The SDS-PAGE results revealed the 6 His fusion proteins (apoE2, apoE3 and apoE4) were correctly expressed and purified successfully.

  11. Radiologically visible fecal gas patterns in ''normal'' newborns and young infants

    Energy Technology Data Exchange (ETDEWEB)

    Patriquin, H.B.; Fisch, C.; Bureau, M.; Black, R.

    1984-02-01

    A prospective study of abdominal and chest films of 212 babies without symptoms of intra-abdominal disease, aged 1 day-12 weeks, showed that the bubbly ''fecal pattern'' normally seen in older children is rare in young premature babies in the first two weeks of life. When it is seen, it may represent intramural air bubbles and signal the presence of necrotizing enterocolitis.

  12. Role of glaciers in watershed hydrology: ''Himalayan catchment'' perspective

    OpenAIRE

    R. J. Thayyen; J. T. Gergan

    2009-01-01

    A large number of Himalayan glacier catchments are under the influence of humid climate with snowfall in winter (November–April) and South-West monsoon in summer (June–September) dominating the regional hydrology. Such catchments are defined as ''Himalayan catchment'', where the glacier melt water contributes to the river flow during the period of annual high flows produced by the monsoon. Other two major glacio-hydrological regimes of the Himalaya are winter snow do...

  13. Moessbauer spectroscopic and electrochemical studies on 1', 1'''-dihalobiferrocenes

    Energy Technology Data Exchange (ETDEWEB)

    Motoyama, Izumi; Suto, Kyoko; Katada, Motomi; Sano, Hirotoshi (Tokyo Metropolitan Univ. (Japan). Faculty of Science)

    1983-08-01

    In the Mossbauer spectroscopic studies on the triiodide salts of a series of 1',1'''-dihalobiferrocenes, it has been found that the monocations of diiodo- and dibromobiferrocene show averaged valence states of iron atoms, while the monocation salt of dichlorobiferrocene shows a trapped valence state of iron atoms. On the other hand, no difference has been found in the half-wave potentials of the halobiferrocenes.

  14. Development of an object oriented lattice QCD code ''Bridge++''

    International Nuclear Information System (INIS)

    We are developing a new lattice QCD code set ''Bridge++'' aiming at extensible, readable, and portable workbench for QCD simulations, while keeping a high performance at the same time. Bridge++ covers conventional lattice actions and numerical algorithms. The code set is constructed in C++ with an object oriented programming. In this paper we describe fundamental ingredients of the code and the current status of development

  15. Avaliação auxológica e reavaliação do Eixo GH-IGF-1 em pacientes com deficiência de GH na infância, após o término do tratamento com hormônios de crescimento e recombinante

    OpenAIRE

    Carvalho, Julienne Angela Ramires de

    2011-01-01

    Resumo: Pacientes com diagnostico de deficiencia de hormonio de crescimento na infancia (GHD) devem ser retestados apos o tratamento, pois nem todos persistem com GHD. Objetivos: Fazer avaliacao auxologica, reavaliar o eixo GH-IGF-1 e a presenca de outras deficiencias hormonais, em pacientes com GHD de inicio na infancia. Material e Metodos: Estudoretrospectivo e prospectivo de 47 pacientes (32 do sexo masculino) atendidos na UEP do HCUFPR, com diagnostico de GHD na infancia, apos o tratament...

  16. Control of releases of radioactive aerosols from object ''Ukryttya'' in 2014

    International Nuclear Information System (INIS)

    The results of control of radioactive particulate emission are presented from the object ''Ukryttya'' in 2014. The maximal rate of unorganized releases of beta-radiating products of Chernobyl accident was in winter period and reached 3.6 MBq/day. The concentration of long-lived beta-radiating aerosols released in atmosphere from system ''Bypass'' was within the range 0.3 - 5 Bq/m3 (maximal concentration was 14 Bq/m3). Them carriers were particles with active median aerodynamic diameter (AMAD) 0.6 - 6 μm. Mean ratio of concentrations were: 137Cs/241Am = 97 i 241Am/154Eu = 6.2. The concentration of 212Pb - daughter products of thoron consisted as a rule 0.8 - 4 Bq/m3. Maximal concentration of 212Pb aerosols was 9 Bq/m3. The relation of concentrations of daughter products of radon and thoron and 212Pb were about 4. They have AMAD 0.06 - 0.3 μm. A volume activity and dispersity of radioactive aerosols in releases from object ''Ukryttya'' remain constant the last ten years

  17. The atmospheric cycling of radiomethane and the ''fossil fraction'' of the methane source

    OpenAIRE

    K. R. Lassey; Lowe, D. C.; Smith, A M

    2006-01-01

    The cycling of 14CH4 (''radiomethane'') through the atmosphere has been strongly perturbed in the industrial era by the release of 14C-free methane from geologic reservoirs (''fossil methane'' emissions), and in the nuclear era, especially since ca 1970, by the direct release of nucleogenic radiomethane from nuclear power facilities. Contemporary measurements of atmospheric radiomethan...

  18. VALORES DO RNI DE PACIENTES SUBMETIDOS AO TRATAMENTO COM ANTICOAGULANTES

    Directory of Open Access Journals (Sweden)

    Simone Aparecida Matos de SOUZA

    2015-12-01

    Full Text Available Uma pesquisa exploratória de natureza qualitativa e quantitativa foi realizada durante o período de maio a agosto de 2013 no Laboratório de Análises Clínicas do Hospital das Clínicas localizado no município de Itaperuna, RJ. O objetivo foi analisar o perfil dos pacientes sob tratamento com anticoagulantes, demonstrando as potenciais variações nos valores da Relação Normalizada Internacional (RNI em comparação aos valores de referência bem como a frequência de realização de tais exames. Um questionário foi aplicado pouco antes da coleta do sangue, estabelecendo-se como critério de inclusão o uso de medicamentos anticoagulantes. Os resultados indicaram um total de 45 pacientes sob tratamento com anticoagulantes, sendo 32 do sexo feminino e 13 do sexo masculino. A maioria dos pacientes encontrava-se sob tratamento com o anticoagulante de uso oral varfarina e se encontrava com idade superior a 50 anos. O valor médio do RNI apresentou-se dentro dos limites considerados seguros, porém mais da metade dos pacientes apresentou RNI < 2,0 e a maioria dos pacientes sob tratamento com anticoagulantes não realiza a avaliação do RNI com frequência.

  19. Tuberculose: sofrimento e ilusões no tratamento interrompido

    Directory of Open Access Journals (Sweden)

    Wilma Suely Batista Pereira

    1999-06-01

    Full Text Available Estudo realizado em Porto Velho (RO, junto a doentes de tuberculose que interromperam o tratamento. A partir da abordagem qualitativa e do método hermenêutico-dialético de análise do material das entrevistas, foi possível inferir que os sujeitos deste estudo têm pouco conhecimento sobre tuberculose e tomam atitudes relacionadas ao impacto que o diagnóstico e o tratamento prolongado causaram a eles próprios e ao seu meio social. Para os doze entrevistados, a interrupção do tratamento relaciona-se a motivos enraizados no não-dito, efeitos colaterais dos medicamentos, desorganização dos serviços e ilusão de estar curado. Isto implica repensarmos nossas posições técnico-metodológicas e as relações profissional-doente, visando a uma abordagem que possibilite encararmos tuberculose-interrupção de tratamento como experiências vividas pelas pessoas, famílias e redes sociais por elas tecidas ao longo do tempo.

  20. Tratamento focal e perifocal contra Aëdes aegypti

    Directory of Open Access Journals (Sweden)

    Milton Moura Lima

    1987-06-01

    Full Text Available Em quatro bairros da cidade do Rio de Janeiro, foram feitos ensaios de tratamento focal com abate granulado a 1 ppm e perifocal com pó molhável de Sumition a 2,5%. Esses tratamentos foram feitos tanto isoladamente quanto em conjunto e, também, associados à aplicação de inseticida a ultrabaixo volume. Os índices prediais, levantados um mês depois de terminado o trabalho, mostraram que o tratamento focal dispensa qualquer medida auxiliar. O tratamento perifocal mostrou-se inócuo e incapaz de impedir o aparecimento de larvas de Aëdes aegypti e de outros insetos, em pneus pintados, na face externa, com Sumition e com Malation.In four districts of the city of Rio dc Janeiro focal treatment essays with granulated Abate at 1 ppm and perifocal treatment essays with wettable powder of Sumithion at 2,5% were performed. These were made either alone or in combination as well as associated to insecticides applied at ultra low volume. The premise indices obtained one month after the treatments indicates that the focal treatment alone is effective, no other addicional methods being necessary. The perifocal treatment is not effective and did not prevent the development of Aedes aegypti larvae and other insects in tires which had their external surface painted with Sumithion and Malathion.

  1. &apos;&apos;Activity based costing&apos;&apos; in radiology; &apos;&apos;Activity based costing&apos;&apos; in der Radiologie

    Energy Technology Data Exchange (ETDEWEB)

    Klose, K.J. [Klinik fuer Strahlendiagnostik, Medizinisches Zentrum fuer Radiologie, Philipps-Universitaet, Marburg (Germany); Boettcher, J. [pphc GmbH, Ammersbeck (Germany)

    2002-05-01

    Background: The introduction of diagnosis related groups for reimbursement of hospital services in Germany (g-drg) demands for a reconsideration of utilization of radiological products and costs related to them. Methods: Traditional cost accounting as approach to internal, department related budgets are compared with the accounting method of activity based costing (ABC). The steps, which are necessary to implement ABC in radiology are developed.Conclusions: The introduction of a process-oriented cost analysis is feasible for radiology departments. ABC plays a central role in the set-up of decentralized controlling functions within this institutions. The implementation seems to be a strategic challenge for department managers to get more appropriate data for adequate enterprise decisions. The necessary steps of process analysis can be used for other purposes (Certification, digital migration) as well. (orig.) [German] Hintergrund. Die Oekonomisierung der Medizin in Deutschland, die in der beabsichtigten Einfuehrung der kostenhomogenen Verguetungsklassen nach den &apos;&apos;diagnosis related groups - DRG&apos;s'&apos; ihren vorlaeufigen Hoehepunkt finden soll, erfordert eine Neuorientierung im Einsatz und in der Beurteilung der Wirtschaftlichkeit radiologischer Verfahren.Methode. Traditionelle Kostenrechnungen bzw. Verfahren zur internen Budgetierung werden der Prozesskostenbetrachtung (&apos;&apos;activity based costing&apos;&apos; - ABC) gegenuebergestellt, deren auf radiologische Belange zugeschnittene Methodik Schritt fuer Schritt entwickelt wird.Ergebnisse. Die Betrachtung radiologischer Arbeitsprozesse auf der Basis des ABC gestattet anhand der bisher publizierten Ergebnisse eine bessere Einschaetzung von Steuerungsimpulsen, die zu einer Effizienzsteigerung in radiologischen Prozessen fuehren koennen.Schlussfolgerungen. Die Einfuehrung einer prozessorientierten Kostenanalyse ist fuer vielfaeltige Belange einer Radiologieabteilung moeglich. Sie stellt

  2. Tratamento do transtorno bipolar: eutimia Bipolar disorder treatment: euthymia

    Directory of Open Access Journals (Sweden)

    Fábio Gomes de Matos e Souza

    2005-01-01

    Full Text Available O transtorno bipolar é um quadro complexo caracterizado por episódios de depressão, mania ou hipomania e fases assintomáticas. O tratamento visa ao controle de episódios agudos e prevenção de novos episódios. O tratamento farmacológico iniciou-se com o lítio. Até o momento, o lítio permanece como o tratamento com mais evidências favoráveis na fase de manutenção. Outros tratamentos demonstram eficácia nessa fase, como o valproato, a carbamazepina e os antipsicóticos atípicos. Dos antipsicóticos atípicos o mais estudado nesta fase do tratamento é a olanzapina. Mais estudos prospectivos são necessários para confirmar a ação profilática de novos agentes.Bipolar disorder is a complex disorder characterized by depression episodes, mania or hypomania and asymptomatic phases. The treatment aims at the control of acute episodes and prevention of new episodes. The pharmacological treatment was inaugurated with lithium. Until the moment, lithium remains as the treatment with more favorable evidences in the maintenance phase. Other treatments demonstrate efficacy in this phase, as valproate, carbamazepine and atypical antipsychotics. Of the atypical antipsychotics, the most studied in this phase of treatment is olanzapine. More prospective studies are necessary to confirm prophylactic action of new agents.

  3. The German &apos;'Energiewende'&apos;. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-08-01

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German &apos;'Energiewende'&apos;. The result is clear-cut: The German &apos;'Energiewende'&apos; is inadequate. Due to the cap-and-trade system of the EU the &apos;''Energiewende'&apos;.

  4. European day &apos;&apos;in town, without my car&apos;&apos;; Journee europeen &apos;&apos;en ville, sans ma voiture&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-10-01

    70 million inhabitants took part in the day &apos;&apos;In town, without my car&apos;&apos; on 22 September of this year. It is a great success for this European first. The objective of Energie-Cites association being to promote sustainable local energy policies, that is to say policies aimed at improving energy efficiency, increasing the use of renewable energy sources and limiting nuisance and pollution linked to energy consumption, the association is pleased that this event helped focus public attention on transport. It is indeed in this sector that uncontrolled upswings in energy consumption and greenhouse gas emissions are the most important. This report presents the evaluation of this European initiative and details the actions in some towns. (A.L.B.)

  5. ECU tendon &apos;'dislocation'&apos; in asymptomatic volunteers

    Energy Technology Data Exchange (ETDEWEB)

    Petchprapa, Catherine N. [New York University Langone Medical Center, Hospital for Joint Diseases, Department of Radiology, New York, NY (United States); Meraj, Seema [Zwanger-Pesiri Radiology Group, Lindenhurst, NY (United States); Jain, Nidhi [New York University School of Medicine, New York University Langone Medical Center, Department of Radiology, New York, NY (United States)

    2016-06-15

    Assess extensor carpi ulnaris (ECU) tendon position in the ulnar groove, determine the frequency of tendon &apos;'dislocation'&apos; with the forearm prone, neutral, and supine, and determine if an association exists between ulnar groove morphology and tendon position in asymptomatic volunteers. Axial proton density-weighted MR was performed through the distal radioulnar joint with the forearm prone, neutral, and supine in 38 asymptomatic wrists. The percentage of the tendon located beyond the ulnar-most border of the ulnar groove was recorded. Ulnar groove depth and length was measured and ECU tendon signal was assessed. 15.8 % of tendons remained within the groove in all forearm positions. In 76.3 %, the tendon translated medially from prone to supine. The tendon &apos;'dislocated'&apos; in 0, 10.5, and 39.5 % with the forearm prone, neutral and supine, respectively. In 7.9 % prone, 5.3 % neutral, and 10.5 % supine exams, the tendon was 51-99 % beyond the ulnar border of the ulnar groove. Mean ulnar groove depth and length were 1.6 and 7.7 mm, respectively, with an overall trend towards greater degrees of tendon translation in shorter, shallower ulnar grooves. The ECU tendon shifts in a medial direction when the forearm is supine; however, tendon &apos;'dislocation'&apos; has not been previously documented in asymptomatic volunteers. The ECU tendon medially translated or frankly dislocated from the ulnar groove in the majority of our asymptomatic volunteers, particularly when the forearm is supine. Overall greater degrees of tendon translation were observed in shorter and shallower ulnar grooves. (orig.)

  6. Students&apos;, Guardians&apos;, and Teachers&apos; Perceptions of Student-Led Conferences

    Science.gov (United States)

    Orso, Charlotte Lindsey

    2013-01-01

    The purpose of the study was to examine the ELL and non-ELL students&apos;, guardians&apos;, and the English as a second language (ESL) teachers&apos; perceptions of student-led conferences. Specifically, the study examined if ELL students&apos; and guardians&apos; preferences were similar to non-ELL students&apos; and guardians&apos; preferences…

  7. Tratamento do Quelóide: O Estado da Arte

    OpenAIRE

    Francisco, R.; Fonseca, F; Pires, M.; Seixo, I; Costa, MJ

    2011-01-01

    Uma das complicações da cicatrização cutânea é a formação de quelóide. O quelóide surge por alterações no processo de cicatrização, com produção excessiva de colagénio e conduzem a limitação estética ou mesmo funcional. Métodos: Revisão bibliográfica do tratamento dos quelóides nos motores de busca PubMed, Gateway Ovid, Medscape. Resultados: O tratamento pode consistir em crioterapia, silicone, pressoterapia, injecção com corticóide, radiação ou cirurgia. Das muitas técnicas usada...

  8. Nuclear waste disposal. A wicked and highly conflict bearing societal problem; Nukleare Entsorgung. Ein &apos;'wicked'&apos; und hoechst konfliktbehaftetes Gesellschaftsproblem

    Energy Technology Data Exchange (ETDEWEB)

    Brunnengraeber, Achim; Mez, Lutz [Freie Univ. Berlin (Germany). Forschungszentrum fuer Umweltpolitik; Di Nucci, Maria Rosaria; Schreuers, Miranda [Freie Univ. Berlin (Germany)

    2012-12-15

    The final disposal of nuclear wastes is called &apos;'messy'&apos; or &apos;'wicked'&apos; in the political science literature. The highly complicated problems are characterized by a number of features such as intra- and inter-generational aspects and ethical questions. In the case of stakeholders the differences concern ideologies, interests, merits and preferences that cause conflicts. The search for solutions is complicated due to interacting political, social, ecologic, economic and technical aspects. The concepts &apos;&apos;wicked problems&apos;&apos; and &apos;'multi-level-governance'&apos; are promising approaches to solve the complicated situation.

  9. Nuclear scanning in necrotizing progressive &apos;'malignant'&apos; external otitis

    Energy Technology Data Exchange (ETDEWEB)

    Parisier, S.C.; Lucente, F.E.; Som, P.M.; Hirschman, S.Z.; Arnold, L.M.; Roffman, J.D.

    1982-09-01

    The usefulness of radionuclear scanning in the treatment of 18 patients with necrotizing progressive &apos;'malignant'&apos; external otitis is discussed. A Tc 99-m bone scan, a valuable test since results are positive in early cases of osteomyelitis of the temporal bone and base of skull, showed increased uptake in all 18 patients. In 6 patients, Ga-67 citrate scans were obtained at the start of therapy and at 5-6 week intervals thereafter. The serial gallium scans were useful in evaluating the effectiveness of therapy since the uptake decrease with control of infection.

  10. Role of glaciers in watershed hydrology: &apos;&apos;Himalayan catchment&apos;&apos; perspective

    Directory of Open Access Journals (Sweden)

    R. J. Thayyen

    2009-07-01

    Full Text Available A large number of Himalayan glacier catchments are under the influence of humid climate with snowfall in winter (November–April and South-West monsoon in summer (June–September dominating the regional hydrology. Such catchments are defined as &apos;&apos;Himalayan catchment&apos;&apos;, where the glacier melt water contributes to the river flow during the period of annual high flows produced by the monsoon. Other two major glacio-hydrological regimes of the Himalaya are winter snow dominated Alpine catchments of the Kashmir and Karakoram region and cold-arid regions of the Ladakh mountain range. Factors influencing the river flow variations in a &apos;&apos;Himalayan catchment&apos;&apos; were studied in a micro scale glacier catchment in the Garhwal Himalaya, covering an area of 77.8 km2. Discharge data generated from three hydrometric stations established at different altitudes of the Din Gad stream during the summer ablation period of 1998, 1999, 2000, 2001, 2003 and 2004. These data has been analysed along with winter/summer precipitation, temperature and mass balance data of the Dokriani glacier to study the role of the glacier and precipitation in determining the runoff variations along the stream continuum from the glacier snout to 2360 m a.s.l. Study shows that the inter-annual runoff variations in a &apos;&apos;Himalayan glacier catchment&apos;&apos; is directly linked with the precipitation rather than mass balance changes of the glacier. Study suggest that warming induced initial increase of glacier degraded runoff and subsequent decline is a glaciers mass balance response and cannot be translated as river flow response in a &apos;&apos;Himalayan catchment&apos;&apos; as suggested by the IPCC, 2007. Study also suggest that the glacier runoff critically influence the headwater river flows during the years of low summer discharge and proposes that the Himalayan catchment could experience higher river flows and positive

  11. &apos;&apos;True believers&apos;&apos; or numerical terrorism at the nuclear power plant

    Energy Technology Data Exchange (ETDEWEB)

    Kraemer, Walter [Technical Univ. Dortmund (Germany). Faculty of Statistics; Arminger, Gerhard [Bergische Univ. Wuppertal (Germany). Schumpeter School of Business and Economics

    2010-09-15

    For decades, there has been a heated debate about whether or not nuclear power plants contribute to childhood cancer in their respective neighbourhoods, with statisticians testifying on both sides. The present paper points to some flaws in the pro-arguments, taking a recent study prepared for the political party &apos;&apos;Buendnis 90 / Gruene&apos;&apos; as a specimen. Typical mistakes include an understatement of the size of tests of significance, disregard of important covariates and extreme reliance on very few selected data points.

  12. The &apos;&apos;Kinetic Stabilizer&apos;&apos;: A Simpler Tandem Mirror Confinement?

    Energy Technology Data Exchange (ETDEWEB)

    Post, R.F.

    2000-06-15

    In the search for better approaches to magnetic fusion it is important to keep in mind the lessons learned in the 50 years that fusion plasma confinement has been studied. One of the lessons learned is that &apos;'closed'&apos; and &apos;'open'&apos; fusion devices differ fundamentally with respect to an important property of their confinement, as follows: Without known exception closed systems such as the tokamak, the stellarator, or the reversed-field pinch, have been found to have their confinement times limited by non-classical, i.e., turbulence-related, processes, leading to the requirement that such systems must be scaled-up in dimensions to sizes much larger than would be the case in the absence of turbulence. By contrast, from the earliest days of fusion research, it has been demonstrated that open magnetic systems of the mirror variety can achieve confinement times close to that associated with classical, i.e., collisional, processes. While these good results have been obtained in both axially symmetric fields and in non-axisymmetric fields, the clearest cases have been those in which the confining fields are solenoidal and axially symmetric. These observations, i.e., of confinement not enhanced by turbulence, can be traced theoretically to such factors as the absence of parallel currents in the plasma, and to the constraints on particle drifts imposed by the adiabatic invariants governing particle confinement in axisymmetric open systems. In the past the MHD instability of axially symmetric open systems has been seen as a barrier to their use. However, theory predicts MHD-stable confinement is achievable if sufficient plasma is present in the &apos;&apos;good curvature&apos;&apos; regions outside the mirrors. This theory has been confirmed by experiments on the Gas Dynamic Trap mirror-based experiment at Novosibirsk, In this paper a new way of exploiting this stabilizing principle, involving creating a localized &apos;&apos

  13. The human apoE7 and apoE4 transgenic mice models

    Institute of Scientific and Technical Information of China (English)

    孙明增; 琦祖和

    2001-01-01

    To scrutinize the disorders caused by human mutant apoE7/apoE4, human apoE4 and E7 transgenic mice were established with microinjection technique to examine molecular genetic phenomena in vivo. The integration and expression of h-apoE mutant genes in transgenic mice were determined with Southern blot, Northern blot and ELISA. The current studies indicated that the transgenes and the phenotypes regarding expression of transgenes could be transmitted stably in transgenic lines. The levels of serum lipid in transgenic mice showed the characteristics of hyperlipidemia. Besides, behavior tests demonstrated the degeneration of learning and memory in transgenic mice. Short life span was observed in 2 transgenic lines. After fed with high lipid food high serum lipid was found both in normal and transgenic mice, but their mechanism regulating lipid metabolism was different. It was also verified that the human apoE mutants located at either N-terminal or C-terminal had the same pathogenesis regarding disorders of lipid metabolism in murine.

  14. Improved Security Via &apos;&apos;Town Crier&apos;&apos; Monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, R. G.; Garcia, A. R. E.; Pacheco, A. N.

    2003-02-26

    Waste managers are increasingly expected to provide good security for the hazardous materials they marshal. Good security requires, among other things, effective tamper and intrusion detection. We have developed and demonstrated a new method for tamper and intrusion detection which we call the &apos;&apos;town crier method&apos;&apos;. It avoids many of the problems and vulnerabilities associated with traditional approaches, and has significant advantages for hazardous waste transport. We constructed two rudimentary town crier prototype systems, and tested them for monitoring cargo inside a truck. Preliminary results are encouraging.

  15. Implications of effects &apos;&apos;adaptive response&apos;&apos;, &apos;&apos;low-dose hypersensitivity&apos;&apos; und &apos;&apos;bystander effect&apos;&apos; for cancer risk at low doses and low dose rates; Implikationen der Effekte &apos;&apos;adaptive response&apos;&apos;, &apos;&apos;low-dose hypersensitivity&apos;&apos; und &apos;&apos;bystander effect&apos;&apos; fuer das Krebsrisiko bei niedrigen Dosen und Dosenraten

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, P (comp.)

    2006-07-01

    A model for carcinogenesis (the TSCE model) was applied in order to examine the effects of &apos;&apos;Low-dose hypersensitivity (LDH)&apos;&apos; and the &apos;&apos;Bystander effect (BE)&apos;&apos; on the derivation of radiation related cancer mortality risks. LDH has been discovered to occur in the inactivation of cells after acute exposure to low LET radiation. A corresponding version of the TSCE model was applied to the mortality data on the Abomb survivors from Hiroshima and Nagasaki. The BE has been mainly observed in cells after exposure to high LET radiation. A Version of the TSCE model which included the BE was applied to the data on lung cancer mortality from the workers at the Mayak nuclear facilities who were exposed to Plutonium. In general an equally good description of the A-bomb survivor mortality data (for all solid, stomach and lung tumours) was found for the TSCE model and the (conventional) empirical models but fewer parameters were necessary for the TSCE model. The TSCE model which included the effects of radiation induced cell killing resulted in non-linear dose response curves with excess relative risks after exposure at young ages that were generally lower than in the models without cell killing. The main results from TSCE models which included cell killing described by either conventional survival curves or LDH were very similar. A sub multiplicative effect from the interaction of smoking and exposure to plutonium was found to result from the analysis of the Mayak lung cancer mortality data. All models examined resulted in the predominant number of Mayak lung cancer deaths being ascribed to smoking. The interaction between smoking and plutonium exposures was found to be the second largest effect. The TSCE model resulted in lower estimates for the lung cancer excess relative risk per unit plutonium dose than the empirical risk model, but this difference was not found to be statistically significant. The excess relative risk dose responses

  16. Efeitos da acupuntura no tratamento da ansiedade: revisao integrativa

    Directory of Open Access Journals (Sweden)

    Sueli Leiko Takamatsu Goyatá

    2016-06-01

    Full Text Available RESUMO Objetivo: avaliar as evidências científicas disponíveis na literatura sobre os efeitos da acupuntura no tratamento da ansiedade e a qualidade desses estudos. Método: revisão integrativa, realizada nas bases/bancos de dados CINAHL, LILACS, PUBMEDPICO, SciELO, The Cochrane Library, no período entre 2001 a 2014. Os descritores anxiety, acupuncture therapy, acupuncture e anxiety disorders foram combinados entre si para garantir a ampla busca de estudos primários. Resultados: dos 514 artigos, 67 foram selecionados para leitura na íntegra e 19 incluídos. Desses, 11 apresentaram forte nível de evidência. Dos seis artigos de estudos clínicos randomizados, cinco apresentaram qualidade classificada como razoável. Dois estudos utilizaram acupunturistas enfermeiros para a aplicação da intervenção. Os resultados mostram efeitos positivos e estatisticamente significativos do uso da acupuntura para tratamento de indivíduos com ansiedade. Conclusão: a acupuntura parece ser um tratamento promissor para a ansiedade, no entanto, há necessidade de melhorar a qualidade metodológica das pesquisas nessa temática.

  17. Do we need a &apos;&apos;green medicine&apos;&apos;?; Brauchen wir &apos;&apos;Gruene Medizin?&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, M.; Daschner, F.; Scherrer, M. [Universitaetsklinikum Freiburg (Germany)

    2006-07-01

    Spontaneously, we do associate &apos;&apos;green medicine&apos;&apos; with terms like naturopathy, natural healing substances, herbal active agents, homeopathy, healthy food, preventive medicine and similar things, and finally we think of ecology. This is the focus of the following article. First of all, the following question arises: Are there any environment-friendly and cost-saving alternatives to the present medicine? There is an increasing number of environment-caused diseases. Therefore, a medicine not coping with the environment is not credible. In today&apos;s medicine, for example, there are too many persistent detergents, water-polluting disinfectants, and many disposable materials. Too much water ist consumed, whereas the use of renewable energies is only limited. And too little natural healing methods are applied in diagnostics and therapy. Presently, in Germany, 16,7 million in-patients are treated in Germany, 1,16 million out-patients have surgeries in 2166 hospitals by ca. 1,1 million medical staff. All this work needs energy and materials which bring various risks to environment and the patients. During the last two decades, however, many efforts were made in the field of environment protection in medicine. There is hardly a hospital left which has not taken measures of protecting the environment. In the branch-specific quality management system KTQ (=cooperation for transparency and quality in the health system). environment protection measures are interrogated and systematically assessed.

  18. The &apos;mini&apos; and &apos;micro&apos; energy sources and their limitations; Les &apos;'minis'&apos; et &apos;'micros'&apos; sources d&apos;energie et leurs limites

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2004-03-01

    The &apos;Science and defense 2003&apos; colloquium took place in Paris on December 2 and 3. It was organized by the general delegation of armament (DGA), the French atomic energy commission (CEA) with the participation of the national center of scientific research (CNRS) and the French ministry of research and new technologies. The main topic was the needs and the solutions implemented in the domain of energy sources both for civil and military portable applications. This article make a general summary of the content of this colloquium only in the domain of small power energy sources: emergence of new miniaturized portable devices (phones, computers, cameras, autonomous medical systems, wireless communication systems, soldiers equipments, drones etc..), improvement of batteries energy density and price, new needs linked with new functionalities, technological challenges (energy generation and recovery systems, miniaturized fuel-cells, use of recoverable energy sources, implantation of power sources in the human body etc..), new technological files (new electrode materials, micron- or sub-micron scale mechanical and electronic components, sensors, micro-motors, transfer of microelectronics technologies, hybrid systems..), international competition. (J.S.)

  19. &apos;&apos;Measuring the Costs of Climate Change Policies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, W. D.; Smith, A. E.; Biggar, S. L.; Bernstein, P.M.

    2003-05-09

    Studies of the costs of climate change policies have utilized a variety of measures or metrics for summarizing costs. The leading economic models have utilized GNP, GDP, the &apos;&apos;area under a marginal cost curve,&apos;&apos; the discounted present value of consumption, and a welfare measure taken directly from the utility function of the model&apos;s representative agent (the &apos;&apos;Equivalent Variation&apos;&apos;). Even when calculated using a single model, these metrics do not necessarily give similar magnitudes of costs or even rank policies consistently. This paper discusses in non-technical terms the economic concepts lying behind each concept, the theoretical basis for expecting each measure to provide a consistent ranking of policies, and the reasons why different measures provide different rankings. It identifies a method of calculating the &apos;&apos;Equivalent Variation&apos;&apos; as theoretically superior to the other cost metrics in ranking policies. When regulators put forward new economic or regulatory policies, there is a need to compare the costs and benefits of these new policies to existing policies and other alternatives to determine which policy is most cost-effective. For command and control policies, it is quite difficult to compute costs, but for more market-based policies, economists have had a great deal of success employing general equilibrium models to assess a policy&apos;s costs. Not all cost measures, however, arrive at the same ranking. Furthermore, cost measures can produce contradictory results for a specific policy. These problems make it difficult for a policy-maker to determine the best policy. For a cost measures to be of value, one would like to be confident of two things. First one wants to be sure whether the policy is a winner or loser. Second, one wants to be confident that a measure produces the correct policy ranking. That is, one wants to have confidence in a policy measure&apos;s ability to correctly rank

  20. Fatores associados a baixa adesao ao tratamento medicamentoso em idosos

    Directory of Open Access Journals (Sweden)

    Noemia Urruth Leao Tavares

    2013-12-01

    Full Text Available OBJETIVO : Analisar fatores associados à baixa adesão ao tratamento medicamentoso em idosos. MÉTODOS : Estudo transversal de base populacional, com amostra representativa de 1.593 indivíduos com 60 anos ou mais, residentes na região urbana de Bagé, RS, em 2008. A amostragem foi realizada em múltiplos estágios. Os dados foram coletados em entrevistas individuais nos domicílios. Analisou-se a associação entre a baixa adesão referida ao tratamento medicamentoso mensurado pelo Brief Medication Questionnaire (BMQ e fatores demográficos, socioeconômicos, comportamentais e de saúde, assistência e prescrição. Foi utilizado modelo de regressão de Poisson para estimar as razões de prevalência bruta e ajustada, os respectivos intervalos de confiança de 95% e p-valor (teste de Wald. RESULTADOS : Cerca de 78,0% dos indivíduos referiram ter usado algum medicamento nos sete dias precedentes à entrevista. Desses, cerca de 1 / 3 foram considerados com baixa adesão ao tratamento. Os fatores significativamente associados à baixa adesão foram: idade (65 a 74 anos, não ter plano de saúde, ter que comprar (totalmente ou em parte os seus medicamentos, ter três ou mais morbidades, possuir incapacidade instrumental para a vida diária e usar três ou mais medicamentos. CONCLUSÕES : A utilização elevada de medicamentos, decorrente da alta prevalência de doenças crônico-degenerativas em idosos, e o acesso ao tratamento devem ser considerados pelos profissionais de saúde para adoção de estratégias que visem diminuir a baixa adesão ao tratamento, aumentando a resolutividade terapêutica e a qualidade de vida desses pacientes.

  1. O tratamento da doenca renal cronica pode afetar a audicao?

    Directory of Open Access Journals (Sweden)

    Priscila Suman Lopez

    2014-01-01

    Full Text Available Introdução: Doença renal crônica (DRC é definida pela presença de lesão renal levando à perda lenta e progressiva da função renal. Objetivo: Comparar testes auditivos entre pacientes com DRC submetidos a diferentes método de tratamento. Material e método: Estudo clínico transversal. Os grupos foram divididos de acordo com o método de tratamento: hemodiálise (n = 35, diálise peritoneal (n =15, conservador (n = 51 e 27 pacientes saudáveis (controle. Pacientes com idade superior a 60 anos, perda auditiva congênita, síndromes genéticas, infecções de orelha média e transplante renal foram excluídos da pesquisa. A avaliação audiológica incluiu audiometria tonal, emissões otoacústicas evocadas transientes e Potencial Evocado Auditivo de Tronco Encefálico (PEATE; e as variáveis avaliadas foram: sexo, idade, diagnóstico de hipertensão arterial e diabetes, estádio da DRC, tempo de diagnóstico do diabetes e da hipertensão arterial, duração da DRC e do tratamento. Resultados: A idade, presença de hipertensão arterial e tempo de DRC foram estatisticamente significantes e controlados. O grupo conservador apresentou piores limiares auditivos na audiometria tonal e o intervalo III-V do PEATE significativamente maior que o da hemodiálise. Conclusão: O tratamento conservador mostrou piores resultados na avaliação auditiva, independente de diabetes e de hipertensão, reforçando que os pacientes submetidos a tratamento para DRC devem realizar avaliação auditiva completa para melhor compreensão da doença e de seus efeitos sobre o sistema auditivo.

  2. Role of the &apos;&apos;fountain effect&apos;&apos; in the equatorial ionosphere in the prolonged retention of radioactive products of the &apos;'Starfish'&apos; explosion at F-region altitudes

    Energy Technology Data Exchange (ETDEWEB)

    Bolyunova, A.D.

    1975-01-01

    The effect of prolonged retention of radioactive products (fission fragments) following the &apos;'Starfish'&apos; thermonuclear explosion at F-region altitudes of the ionosphere of lower and middle latitudes discovered on the Kosmos 3, Kosmos 5, and Kosmos 6 satellites is analyzed from the point of view of concepts concerning ion transport processes in the equatorial ionosphere. A qualitative explanation for this phenomenon based on the &apos;&apos;fountain effect&apos;&apos; in the equatorial ionosphere is proposed which is in satisfactory agreement with experiment.

  3. &apos;Teleparallel&apos; dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Geng, Chao-Qiang, E-mail: geng@phys.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China); National Center for Theoretical Sciences, Hsinchu 300, Taiwan (China); Lee, Chung-Chi, E-mail: g9522545@oz.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China); Saridakis, Emmanuel N., E-mail: Emmanuel_Saridakis@baylor.edu [CASPER, Physics Department, Baylor University, Waco, TX 76798-7310 (United States); National Center for Theoretical Sciences, Hsinchu 300, Taiwan (China); Wu, Yi-Peng, E-mail: s9822508@m98.nthu.edu.tw [Department of Physics, National Tsing Hua University, Hsinchu 300, Taiwan (China)

    2011-10-25

    Using the &apos;teleparallel&apos; equivalent of General Relativity as the gravitational sector, which is based on torsion instead of curvature, we add a canonical scalar field, allowing for a nonminimal coupling with gravity. Although the minimal case is completely equivalent to standard quintessence, the nonminimal scenario has a richer structure, exhibiting quintessence-like or phantom-like behavior, or experiencing the phantom-divide crossing. The richer structure is manifested in the absence of a conformal transformation to an equivalent minimally-coupled model.

  4. Novel action of apolipoprotein E (ApoE: ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons

    Directory of Open Access Journals (Sweden)

    Fujita Shinobu C

    2007-05-01

    Full Text Available Abstract Background Since the majority of apolipoprotein E (apoE existing in the cerebrospinal fluid is associated with high-density lipoprotein (HDL, one should focus on the role of the apoE-HDL complex rather than on that of free apoE in cholesterol metabolism in the central nervous system. However, the apoE-isoform-specific effect of apoE-HDL on cholesterol transport remains unclarified. Results Here we show that apoE3-HDL induced a marked cholesterol release from neurons, while apoE4-HDL induced little. To elucidate the mechanism underlying this phenomenon, we used a complex of lipid emulsion (EM with recombinant apoE3 or apoE4 (apoE-EM at various apoE concentrations. When a small number of apoE molecules were associated with EM, apoE3- and apoE4-EM, induced a marked cholesterol release to a level similar to that induced by EM alone. However, when apoE at given concentrations was incubated with EM, apoE3-EM induced a marked cholesterol release, while apoE4-EM induced little. Under these conditions, a greater number of apoE4 molecules were associated with EM than apoE3 molecules. When an increasing number of apoE molecules were associated with EM, both apoE3-EM and apoE4-EM induced little cholesterol release. Preincubation with β-mercaptoethanol increased the number of apoE3 molecules associated with EM similar to that of apoE4 molecules, indicating that the presence (apoE3 or absence (apoE4 of intermolecular disulfide bond formation is responsible for the association of a greater number of apoE4 molecules to EM than apoE3 molecules. Conclusion These results suggest that although apoE and a lipid particle are lipid acceptors, when apoE and a lipid particle form a complex, apoE on the particle surface inhibits the lipid particle-mediated cholesterol release from cells in an apoE-concentration-dependent manner.

  5. Preparation of data relevant to &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and Equivalent Initial Enrichment&apos;&apos; for burnup credit evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Nomura, Yasushi; Okuno, Hiroshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment; Murazaki, Minoru [Tokyo Nuclear Service Inc., Tokyo (Japan)

    2001-11-01

    Based on the PWR spent fuel composition data measured at JAERI, two kinds of simplified methods such as &apos;&apos;Equivalent Uniform Burnup&apos;&apos; and &apos;&apos;Equivalent Initial Enrichment&apos;&apos; have been introduced. And relevant evaluation curves have been prepared for criticality safety evaluation of spent fuel storage pool and transport casks, taking burnup of spent fuel into consideration. These simplified methods can be used to obtain an effective neutron multiplication factor for a spent fuel storage/transportation system by using the ORIGEN2.1 burnup code and the KENO-Va criticality code without considering axial burnup profile in spent fuel and other various factors introducing calculated errors. &apos;&apos;Equivalent Uniform Burnup&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis, in which the experimentally obtained isotopic composition together with a typical axial burnup profile and various factors such as irradiation history are considered on the conservative side. On the other hand, Equivalent Initial Enrichment&apos;&apos; is set up for its criticality analysis to be reactivity equivalent with the detailed analysis such as above when it is used in the so called fresh fuel assumption. (author)

  6. &apos;'VaneCAM'&apos; - the third generation of camshaft adjustment systems; &apos;'VaneCAM'&apos; - Nockenwellenversteller der dritten Generation

    Energy Technology Data Exchange (ETDEWEB)

    Knecht, A. [Hydraulik-Ring GmbH, Nuertingen (Germany). Entwicklung Motorentechnik; Stephan, W. [Hydraulik-Ring GmbH, Nuertingen (Germany); Hannibal, W. [Fachhochschule Suedwestfalen, Iserlohn (Germany). Labor fuer Konstruktion und CAE-Anwendungen

    2002-04-01

    Continuously variable camphasers are now well established for modern spark-ignition engines in high-volume production. With the latest generation of camshaft adjustment systems using the vane-type actuator principle, it is possible to move rapidly and reliably through a large adjustment angle. The layout of these adjusting systems is very simple. The production costs are low in comparison to the first generation of camphasers using spur/helical gears to vary the valve timing. The new-generation systems are mechatronic, with the function depending on the coordination and tuning of hydraulic actuation and engine electronics. The term &apos;VaneCAM&apos; is used for the continuously variable systems of this new generation supplied by Hydraulik-Ring in Nuertingen, Germany. (orig.) [German] Stufenlos wirkende Nockenwellenversteller haben sich an modernen Ottomotoren in den letzten Jahren in der Grossserie etabliert. Mit der neuesten Generation von Nockenwellenverstellern, die nach dem Schwenkmotor-Prinzip aufgebaut sind, lassen sich grosse Verdrehwinkel sehr schnell und betriebssicher verstellen. Der Aufbau dieser Versteller ist einfach, und die Herstellkosten sind gering im Vergleich zur ersten Generation von Verstellern. Bei den Systemen der neuen Generation handelt es sich um mechatronische Systeme, deren Funktion von dem Zusammenspiel und der Abstimmung von hydraulischer Ansteuerung und Motorelektronik abhaengt. Mit dem Begriff &apos;VaneCAM&apos; werden die stufenlos wirkenden Systeme dieser neuen Generation von Hydraulik-Ring aus Nuertingen bezeichnet. (orig.)

  7. Orbit as a Mirror of Systemic Disease; &apos;&apos; Epidemiologic, Clinical and Imaging &apos;&apos;

    Directory of Open Access Journals (Sweden)

    Aliakbar Ameri

    2009-01-01

    Full Text Available   "n1- Infectious: toxoplasmosis , toxocariasis ,TB , syphilis , leprosy , HIV , CMV. "n2- Non infectous: endocrine, diabetes, thyroid, connective tissue disease &apos;&apos;RA, SLE, wegeners, PAN, systemic sclerosis&apos;&apos;, vasculitides, GCA&apos;&apos;, sarcoidosis, behcet&apos;s disease, vogt koyangi harada syndrome, phakomatoses. "nAll diseases should be demonstrated by clinical images and imaging slides. "n-imaging "nX-RAY, high frequency US and color doppler, 2D and 3D X-RAY CT, MRI: "n1- X-RAY: in fractures, foreign bodies, skull combined anomalies and few other cases. "n2-High-frequency ultrasound for posterior chamber and ciliary body micro-anatomic changes &apos;&apos; tumors granulations&apos;&apos;. "nColor Doppler study for vascular lesions, central retin artery, tumors in the globe and retrobulbar region. "n3- X-RAY CT for tumors, 2D and 3D for fractures, 3D for bone anatomy, foreign body &apos;&apos; modality of choice is 2directional 2D CT scan &apos;&apos;, sino-nasal diseases, CT-angiography or phlebography in large vessel evaluation, DSA for small vessel anatomy. "n4- MRI for tumors and infection also granulation process. "nMRI and MRV in large vessel anatomy, functional – MRI for the visual pathway, tractography. "nConclusion : "nModality of choice : "n1- CT for foreign bodies &apos;&apos; MRI is contra-indicated in the first step specially in metallic fragments &apos;&apos;. CT for micro-calcification &apos;&apos; retinoblastoma &apos;&apos;,CT for fractures. "n2- MRI for tumors, biometry, soft tissue disease and functional imaging. "n3- DSA for vascular disease of the eye. "n4- U.S for biometery, posterior Chamber, iris and ciliary body lesions. 5- Fluorescein angiography for the retina.  

  8. What do we mean by the word &apos;'Shock'&apos;?

    International Nuclear Information System (INIS)

    From one vantage point, a shock is a continuous but drastic change in state variables that occurs over very small time and length scales. These scales and associated changes in state variables can be measured experimentally. From another vantage point, a shock is a mathematical singularity consisting of instantaneous changes in state variables. This more mathematical view gives rise to analytical solutions to idealized problems. And from a third vantage point, a shock is a structure in a hydrocode prediction. Its width depends on the simulation&apos;s grid resolution and artificial viscosity. These three vantage points can be in conflict when ideas from the associated fields are combined, and yet combining them is an important goal of an integrated modeling program. This presentation explores an example of how models for real materials in the presence of real shocks react to a hydrocode&apos;s numerical shocks of finite width. The presentation will include an introduction to plasticity for the novice, an historical view of plasticity algorithms, a demonstration of how pursuing the meaning of &apos;'shock'&apos; has resulted in hydrocode improvements, and will conclude by answering some of the questions that arise from that pursuit. After the technical part of the presentation, a few slides advertising LANL&apos;s Computational Physics Student Summer Workshop will be shown.

  9. Fatores de risco cardiovascular em alcoolistas em tratamento

    Directory of Open Access Journals (Sweden)

    Mayla Cardoso Fernandes Toffolo

    2013-06-01

    Full Text Available OBJETIVO: Avaliar a presença de fatores de risco cardiovascular, com ênfase na hipertensão e na adiposidade corporal, em alcoolistas abstinentes ou não abstinentes em tratamento. MÉTODO: Trata-se de um estudo transversal com 65 pacientes alcoolistas em tratamento no CAP-Sad. O grau de dependência do álcool foi avaliado pelo SADD (Short Alcohol Dependence Data e o uso de outras drogas, pelo ASSIST (Alcohol Smoking and Substance Involvement Screening Test. Foram avaliados o perfil bioquímico e o antropométrico dos usuários. RESULTADOS: Participaram do estudo 42 homens e 23 mulheres. A maioria dos participantes (67,74% apresentou dependência alcoólica grave, com uso de álcool associado principalmente a cigarro (66,15%. A média da circunferência da cintura (CC foi significativamente maior entre os abstinentes, em comparação aos não abstinentes (AB: 88,15 ± 15,95 x NA: 81,04 ± 9,86; p = 0,03. Pacientes abstinentes há mais tempo tiveram maior sobrepeso/obesidade e adiposidade abdominal (CC do que os não abstinentes e abstinentes recentes, com razão de chances de 5,25. Os abstinentes apresentaram razão de chances de 3,38 para %GC acima da média, independente do tempo de abstinência. CONCLUSÃO: Pacientes alcoolistas abstinentes apresentam mais sobrepeso/ obesidade, adiposidade corporal (%GC e abdominal (CC do que os não abstinentes. É importante o acompanhamento multiprofissional no tratamento de alcoolistas com abordagem para fatores de risco cardiovasculares, principalmente evitando o ganho de peso.

  10. Sustainable Agriculture: enhancing the &apos;neem cake&apos;

    International Nuclear Information System (INIS)

    The &apos;neem cake&apos; is the scrap processing of the industrial chain producing neem oil and azadirachtin. The ENEA Technical Unit Environment and Sustainable Development Innovation the Agro-Industrial System, developed a promising experiment to promote the use of &apos;neem cake&apos; as an insecticide, and fertilizer of low cost in sustainable agriculture.

  11. &apos;Portico&apos; in the Munich MP-tandem

    Energy Technology Data Exchange (ETDEWEB)

    Muenzer, H.; Carli, W.; Hartung, P.; Rohrer, L.; Schnitter, H.; Assmann, W.

    1986-02-15

    A &apos;'portico'&apos; was installed with the aim of preventing spark damage to column components and of increasing the terminal voltage. First experiences: no spark damage is observed, especially deconditioning of accelerating tubes by the sparks has disappeared. No significant increase in terminal voltage due to axial effects has been attained. (orig.).

  12. Parents&apos; Views of Schools&apos; Involvement Efforts

    Science.gov (United States)

    Rodriguez, Raymond J.; Blatz, Erin T.; Elbaum, Batya

    2014-01-01

    Individual and focus group interviews were conducted with 96 parents of students with disabilities in 18 schools to explore parents&apos; views of schools&apos; efforts to engage them in their child&apos;s education. A mixed-methods approach was used to identify and evaluate the relative importance of eight themes related to schools&apos; efforts…

  13. Personangens virtuais no tratamento do controlo de ansiedade

    OpenAIRE

    Lopes, Eder Wolsen Henriques

    2013-01-01

    Trabalho de projecto de mestrado em Informática, apresentado à Universidade de Lisboa, através da Faculdade de Ciências, 2013 A ansiedade social é um transtorno comum que se pode revelar muito debilitante e que, quando não é tratada devidamente, pode evoluir para patologias graves como fobias e até mesmo depressão. Atualmente existem dois métodos cientificamente aceites no tratamento da ansiedade social: a utilização de produtos farmacológicos e a terapia cognitivo-comportamental. A terapi...

  14. Compostos bioativos de microalgas com interesse no tratamento da diabetes

    OpenAIRE

    Gago, Alexandre da Silva

    2016-01-01

    Dissertação de Mestrado, Biologia Molecular e Microbiana, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2016 A diabetes é uma doença que afeta milhões de pessoas em todo o mundo e condiciona a qualidade de vida das mesmas. A diabetes tipo 2 tem merecido destaque pelo aumento da sua incidência e pelo facto de ser uma doença evitável. O tratamento atualmente resume-se a medicação específica juntamente com uma dieta bastante restritiva. As microalgas sendo conhecida...

  15. 10 anos de experiência no tratamento de retinoblastoma

    OpenAIRE

    Santos, C.; Coutinho, I; Azevedo, AR; Constantino, C.; Sousa, AB; Pereira, F.; Laranjeira, J; Cabral, J.; Teixeira, S.

    2015-01-01

    Objectivo: Descrever a experiência do Serviço de Oftalmologia do Hospital Prof. Doutor Fernando Fonseca no diagnóstico e tratamento de retinoblastoma entre Janeiro de 2004 e Dezembro de 2014. Métodos: Revisão retrospectiva dos processos clínicos e exames complementares de diagnóstico. Resultados: Foram tratados dezasseis doentes no período em estudo, sendo cinco casos bilaterais . O diagnóstico foi estabelecido em média aos 27 meses de idade e a forma de apresentação mais frequente...

  16. HIPERSENSIBILIDADE DENTINÁRIA: DIAGNÓSTICO E TRATAMENTO

    Directory of Open Access Journals (Sweden)

    VALE Ilan Sampaio do

    1997-01-01

    Full Text Available A hipersensibilidade é a sensibilidade exagerada da dentina quando exposta ao meio bucal, que se torna permeável à ação de estímulos agressivos. O diagnóstico é feito através da anamnese e da inspeção clínica minuciosa. O tratamento pode ser feito pelo profissional ou pelo próprio paciente sob orientação, dependendo do caso. Ela ocorre comumente no final da terceira década, sendo ligeiramente mais freqüente nas mulheres do que nos homens.

  17. Realidade virtual aplicada ao tratamento da ansiedade social

    OpenAIRE

    Pinheiro, Tânia Cristina Martins

    2012-01-01

    Trabalho de projecto de mestrado em Engenharia Informática (Engenharia de Software), apresentado à Universidade de Lisboa, através da Faculdade de Ciências, 2012 A ansiedade social é uma patologia debilitante que prejudica e diminui a qualidade de vida. O tratamento existe e ´e composto por várias terapias realizadas em simultâneo, sendo uma delas a terapia de exposição¸. Com a evolução tecnológica, surgiu a possibilidade de aplicar a Realidade Virtual `a terapia de exposição¸ (Terapia de ...

  18. Tratamento das cefaléias Treatment of headaches

    Directory of Open Access Journals (Sweden)

    José Luiz Dias Gherpelli

    2002-08-01

    Full Text Available Objetivo: realizar revisão bibliográfica sobre o tema tratamento da cefaléia na infância e adolescência. Fontes dos dados: revisão bibliográfica através do banco de dados Medline, utilizando os termos: cefaléia, enxaqueca ou migrânea, infância ou adolescência e tratamento, no período de 1966 a 2001, excluindo artigos de revisão e registros de casos. Foram selecionados artigos científicos que relataram estudos sobre a eficácia da terapêutica farmacológica e não farmacológica no tratamento das cefaléias primárias. Síntese dos dados: foram encontrados 104 artigos científicos, sendo selecionados aqueles que relataram estudos do tipo caso-controle, ou droga versus placebo, cegos ou abertos, e que estudassem crianças ou adolescentes. Conclusões: é digna de nota a pobreza de estudos controlados sobre o tema na faixa etária pediátrica, apesar da importância que as cefaléias primárias apresentam na prática clínica. Apenas algumas drogas foram estudadas de forma cientificamente adequada e, mesmo assim, o número de estudos é pequeno. Tanto o tratamento da crise álgica aguda quanto a profilaxia da cefaléia foram abordados.Objective: to perform a bibliographic review about headache treatment in childhood and adolescence. Sources: articles were searched through Medline database using the terms: migraine, or headache, childhood, or adolescence, and treatment, during the period between 1966 and 2001. Review articles and case reports were excluded. Only articles dealing with pharmacological, and non-pharmacological treatment of primary headaches were selected. Summary of the findings: a total of 104 articles were found; only those reporting results of the case-control studies, or drug vs. placebo, either blind, or open, and that included children, or adolescents were selected. Conclusions: only a few controlled studies about the headache treatment were found in the pediatric age group, although primary headaches are

  19. Tratamento da doença de Parkinson

    OpenAIRE

    Francisco Cardoso

    1995-01-01

    Doença de Parkinson (DP) é a causa mais freqüente de parkinsonismo em nosso meio, responsável por 58% dos casos. Devem-se excluir outras causas, como uso de drogas antidopaminérgicas (20% dos casos). Levodopa é o agente mais importante para o tratamento de DP. Há controvérsia sobre quando se introduzir esta droga mas deve-se reservá-la para quando surgir substancial comprometimento funcional. Drogas acessórias são anticolinérgicos, úteis para o tremor; amantadina, para bradicinesia e rigidez;...

  20. Overview of &apos;&apos;Red Oil&apos;&apos; Frequency Analyses for F-Canyon

    Energy Technology Data Exchange (ETDEWEB)

    Lux, C.R.

    2000-07-19

    A very small potential exists in the Savannah River Site (SRS) separations operations for an uncontrolled reaction between tri-n-butyl phosphate (TBP) and nitric acid that could result in unacceptable damage to separations facilities and a significant release of radioactive materials. The recent &apos;&apos;red oil&apos;&apos; (TBP and nitric acid) accident in Tomsk, Russia, resulted in considerable damage and radioactive release. Explosions have also occurred at SRS during the early years of operations. While the SRS separations facilities have operated without incident for many years, it is prudent to revisit the SRS defense-in-depth approach to preventing such an accident and to upgrade preventive procedures and hardware as appropriate.

  1. &apos;'Beaded'&apos; osteoid osteoma: a possible transition between solitary and multicentric tumor

    Energy Technology Data Exchange (ETDEWEB)

    Chiou, Yi-You [Department of Radiology, Taipei Veterans General Hospital, 201 Sec. 2 Shih-Pai Road, 11217, Taipei (Taiwan); Rosenthal, Daniel I. [Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (United States); Rosenberg, Andrew E. [Department of Pathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 (United States)

    2003-07-01

    An extremely rare example of an elongated (3 cm) osteoid osteoma is presented. The tumor demonstrated three focal enlargements connected by narrow areas, suggesting a &apos;&apos;string of beads&apos;&apos; in appearance. The elongated shape suggested the possibility that lesional tissue was stretched in a longitudinal fashion as a result of the rapid skeletal growth. The tumor closest to the growth plate was densely ossified, while the furthest lesion was almost completely lytic, suggesting that the tumor enlarged in a centripetal direction. This case is believed to illustrate a continuum from solitary to multicentric osteoid osteoma. The tumor was treated successfully with three separate percutaneous radiofrequency ablations during a single session. (orig.)

  2. THE FIRST &apos;&apos;WATER FOUNTAIN&apos;&apos; COLLIMATED OUTFLOW IN A PLANETARY NEBULA

    Energy Technology Data Exchange (ETDEWEB)

    Gómez, José F.; Miranda, Luis F.; Guerrero, Martín A. [Instituto de Astrofísica de Andalucía, CSIC, Glorieta de la Astronomía s/n, E-18008 Granada (Spain); Suárez, Olga; Bendjoya, Philippe; Lagadec, Eric [Laboratoire Lagrange, UMR 7293, Université de Nice Sophia-Antipolis, CNRS, Observatoire de la Côte d' Azur, F-06304 Nice (France); Rizzo, J. Ricardo; García-García, Enrique [Centro de Astrobiología (INTA-CSIC), Ctra. M-108, km. 4, E-28850 Torrejón de Ardoz (Spain); Green, James A. [CSIRO Astronomy and Space Science, Australia Telescope National Facility, P.O. Box 76, Epping, NSW 1710 (Australia); Uscanga, Lucero [Institute of Astronomy, Astrophysics, Space Applications and Remote Sensing, National Observatory of Athens, 15236 Athens (Greece); Ramos-Larios, Gerardo [Instituto de Astronomía y Meteorología, Av. Vallarta No. 2602, Col. Arcos Vallarta, C.P. 44130 Guadalajara, Jalisco (Mexico)

    2015-02-01

    &apos;&apos;Water fountains&apos;&apos; (WFs) are evolved objects showing high-velocity, collimated jets traced by water maser emission. Most of them are in the post-asymptotic giant branch (post-AGB) and they may represent one of the first manifestations of collimated mass loss in evolved stars. We present water maser, carbon monoxide, and mid-infrared spectroscopic data (obtained with the Australia Telescope Compact Array, Herschel Space Observatory, and the Very Large Telescope, respectively) toward IRAS 15103–5754, a possible planetary nebula (PN) with WF characteristics. Carbon monoxide observations show that IRAS 15103–5754 is an evolved object, while the mid-IR spectrum displays unambiguous [Ne II] emission, indicating that photoionization has started and thus, its nature as a PN is confirmed. Water maser spectra show several components spreading over a large velocity range (≅ 75 km s{sup –1}) and tracing a collimated jet. This indicates that the object is a WF, the first WF known that has already entered the PN phase. However, the spatial and kinematical distribution of the maser emission in this object are significantly different from those in other WFs. Moreover, the velocity distribution of the maser emission shows a &apos;'Hubble-like'&apos; flow (higher velocities at larger distances from the central star), consistent with a short-lived, explosive mass-loss event. This velocity pattern is not seen in other WFs (which are presumably in earlier evolutionary stages). We therefore suggest that we are witnessing a fundamental change of mass-loss processes in WFs, with water masers being pumped by steady jets in post-AGB stars, but tracing explosive/ballistic events as the object enters the PN phase.

  3. Trends in Energy. &apos;The consumer decides&apos;; Trends in Energy. &apos;De consument bepaalt&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Brzezowsky-Ruys, Y.; Van der Zalm, M.; Van Zutphen, M. (eds.)

    2012-03-15

    A report is given of the Capgemini organised congress &apos;Trends in Energy 2011&apos; which has the Dutch subtitle &apos;De consument bepaalt&apos; (The consumer decides&apos;. The focus of the articles, interviews, debates and presentations is on the role of the consumer in the supply of and demand for energy. Parts of the report are in Dutch and English [Dutch] Dit rapport bestaat uit een verslag van het congres &apos;Trends in Energy 2011. De consument bepaalt&apos; en een aantal artikelen met achtergrondinformatie over onder meer de rol van de consument in vraag en aanbod van energie.

  4. Tratamento do transtorno esquizoafetivo Treatment of the schizoaffective disorder

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    Lucas de Castro Quarantini

    2005-01-01

    Full Text Available O tratamento farmacológico do transtorno esquizoafetivo (TE é usualmente realizado com antipsicóticos, estabilizadores do humor e antidepressivos. Verifica-se a falta de estudos epecificamente desenhados para avaliar a resposta de pacientes esquizoafetivos à medicação. Portanto, as informações sobre o tratamento de pacientes com TE são derivadas de bancos de dados de paciente com esquizofrenia e transtornos bipolares. Dados de pesquisa apóiam a idéia de um continuum entre os transtornos bipolares e a esquizofrenia. As duas condições podem ser tratadas com antipsicóticos, o que pode refletir uma base fisiopatológica comum para ambas.The pharmacological treatment of schizoaffective disorders (SD is usually carried out with antipsychotics, mood stabilizers and antidepressants. There is a lack of clinical trials specifically designed to assess the clinical response of schizoaffective patients to medication. Therefore, data on the treatment of patients with SD is largely derived from datasets of patients with schizophrenia and bipolar disorders. Research data support the idea of a continuum between bipolar and schizophrenic disorders. Both disorders can be treated with antipsychotics and this may reflect a common pathophysiological diathesis.

  5. Diverticulopexia no tratamento do divertículo de Zenker

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    Renato Micelli Lupinacci

    2013-02-01

    Full Text Available O divertículo de Zenker é um pseudodivertículo que se origina de um defeito muscular na parede posterior da faringe, na área de transição entre o músculo constritor inferior da faringe e o músculo cricofaringeo. Apesar do avanço das técnicas endoscópicas, o tratamento cirúrgico persiste como o tratamento padrão. Duas técnicas são possíveis: diverticulectomia (ressecção do divertículo e a diverticulopexia. As vantagens da diverticulopexia estão ligadas à ausência de anastomose esofágica e suas possíveis complicações: fistulas cervicais, mediastinite, estenose esofágica e infecção de ferida. Em ambas as técnicas a secção das fibras musculares do músculo cricofaringeo (ou, esfíncter superior do esôfago é fundamental. O objetivo do presente artigo é descrever em detalhes a técnica de diverticulopexia junto ao ligamento pré-vertebral associada à miotomia do músculo cricofaríngeo.

  6. Fadiga em idosos em tratamento quimioterápico

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    Thalyta Cristina Mansano-Schlosser

    2014-08-01

    Full Text Available Pesquisa com delineamento transversal, realizada de agosto a dezembro de 2010, que objetivou identificar a presença e intensidade da fadiga em 140 idosos (média de idade 69,8 anos, 52,1% do sexo feminino com diagnóstico de câncer, em tratamento quimioterápico ambulatorial. Utilizou-se um questionário para caracterização sociodemográfica e clínica e a Escala de Fadiga de Piper-revisada. Identificou-se a presença de fadiga em 60 idosos (42,9% e a causa atribuída foi o câncer (64,1%, a quimioterapia (32,8% e o tratamento (3,1%. Como fator de alívio, os idosos entrevistados relataram "dormir", "rezar" e "morrer", enquanto 45% deles disseram "não ter o que fazer", pois a fadiga não poderia ser aliviada. Espera-se que este estudo alerte os profissionais de enfermagem para a relevância da fadiga e os estimule a identificar e realizar intervenções de enfermagem que visem o adequado manejo desse sintoma no paciente idoso oncológico.

  7. Molecules with &apos;'wheels'&apos; on a metal surface

    Energy Technology Data Exchange (ETDEWEB)

    Villagomez, Carlos; Grill, Leonhard [Institut fuer Experimentalphysik, Freie Universitaet Berlin (Germany); Sasaki, Takashi; Tour, James M. [Chemistry Department, Rice University, Houston, TX (United States)

    2009-07-01

    The design and creation of molecular nanostructures with specific mechanical functions is one of the fundamental issues in nanotechnology. In this context, wheels are an interesting component for the molecular motion, because they are expected to alter the diffusion properties on surfaces, for instance by allowing only directed motion. In the presented work, we show the absorption of functional molecules studied by scanning tunneling microscopy under ultrahigh vacuum at low temperatures of about 7 K. The molecules consist of a phenyl chain, equipped with carborane side groups that represent the molecular &apos;'wheels'&apos;. Additionally, bromine atoms are attached to the terminal groups of the molecules, which should allow the covalent connection of individual molecules, according to our recently presented oen-surface-synthesis&apos;&apos; method. The high mobility of the molecules during deposition, at room temperature, enables them to form molecular nanostructures. Characteristic appearances of the molecules, due to different molecular configurations, are found. Furthermore, lateral manipulation was used to displace molecules and to probe their intermolecular interactions.

  8. Efetividade do tratamento da tuberculose Effectiveness of tuberculosis treatment

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    Letícia Nazareth Fernandes da Paz

    2012-08-01

    Full Text Available OBJETIVO: Analisar as estratégias que influenciam a efetividade do tratamento da tuberculose em Unidades Básicas de Saúde (UBS. MÉTODOS: Levantamento epidemiológico, descritivo, retrospectivo, envolvendo os prontuários médicos de 588 pacientes com tuberculose cadastrados no programa de controle da tuberculose, entre janeiro de 2004 e dezembro de 2008, em duas UBS - Centro de Saúde Escola do Marco (CSEM e UBS da Pedreira (UBSP - localizadas na cidade de Belém (PA. Os critérios de exclusão foram ter idade 59 anos e ter alta por transferência ou mudança de diagnóstico. Os dados coletados foram idade, sexo, tipo de tratamento (autoadministrado ou supervisionado, coinfecção por HIV e desfecho do tratamento. Os profissionais de saúde envolvidos no programa da tuberculose das duas UBS foram entrevistados quanto às estratégias utilizadas no controle da doença e à rotina de atendimento. RESULTADOS: Não houve diferenças significativas quanto a idade, sexo e coinfecção com HIV nas duas UBS. A utilização de tratamento supervisionado foi significativamente maior no CSEM que na UBSP, assim como a taxa de cura, enquanto a taxa de abandono foi maior na UBSP que no CSEM. CONCLUSÕES: Para pacientes cadastrados em programas de controle da tuberculose em UBS no Brasil, o tratamento supervisionado provavelmente é uma estratégia de extrema importância para se alcançar uma menor taxa de abandono.OBJECTIVE: To analyze the treatment strategies that influence the effectiveness of tuberculosis treatment at primary care clinics (PCCs in Brazil. METHODS: This was a descriptive, retrospective epidemiological survey based on the medical records of 588 tuberculosis patients enrolled in the tuberculosis control programs at two PCCs located in the city of Belém, Brazil: Centro de Saúde Escola do Marco (CSEM and Unidade Básica de Saúde da Pedreira (UBSP. The survey was limited to patients enrolled between January of 2004 and December of 2008

  9. Tratamento adjuvante nos GISTs Adjuvant treatment in GISTs

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    Laercio Gomes Lourenço

    2011-09-01

    Full Text Available INTRODUÇÃO: O tumor estromal gastrointestinal (GIST é o sarcoma mais comum do aparelho digestivo. Essa neoplasia ocorre devido à mutação do gene KIT com consequente ativação constitutiva da proteína KIT. O tratamento primário é cirúrgico e consiste na sua ressecção completa. Entretanto, alguns grupos de pacientes apresentam risco elevado de recorrência mesmo após operação com ressecção completa (R0, indicando diferenças no comportamento biológico. Estudos clínicos comprovaram a atividade clínica do mesilato de imatinibe, fazendo dele a primeira linha de tratamento padrão nos GISTs metastáticos ou irressecáveis, mudando muito o desfecho clínico dessa doença em relação aos benefícios anteriormente obtidos com a quimioterapia antineoplásica. MÉTODO: Foi realizada revisão da literatura com consulta nos periódicos das bases Medline/Pubmed, Scielo e Lilacs cruzando os descritores: tumor estromal gastrointestinal, Gist, tratamento, adjuvância. Além desta revisão foi adicionada a experiência pessoal dos autores. CONCLUSÃO: Melhor refinamento dos critérios de prognóstico tem permitido selecionar de forma mais adequada pacientes para o tratamento adjuvante com imatinibe. Os resultados de maior evidência até o momento respaldam o tratamento adjuvante por um ano, o que produz benefício significativo na sobrevida livre de recidiva, mas não na sobrevida global desses pacientes.INTRODUCTION: Gastrointestinal stromal tumor (GIST is the most common sarcoma of the digestive tract. This cancer occurs due to mutation of the KIT gene resulting in constitutive activation of KIT protein. The primary treatment is surgical and consists of complete resection. However, some groups of patients at high risk of recurrence even after surgery with complete resection (R0, indicate differences in biological behavior. Clinical studies have demonstrated the clinical activity of imatinib mesylate, making it the standard first

  10. Solid state laser technology for inertial confinement fusion: A collection of articles from &apos;&apos;Energy and Technology Review&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    1988-06-01

    This paper contains reprinted articles that record several milestones in laser research at LLNL. &apos;&apos;Neodymium-Glass Laser Research and Development at LLNL&apos;&apos; recounts the history of the Laser Program and our work on neodymium-glass lasers. &apos;&apos;Nova Laser Technology&apos;&apos; describes the capabilities of the Nova laser and some of its uses. &apos;&apos;Building Nova: Industry Relations and Technology Transfer&apos;&apos; illustrates the Laboratory&apos;s commitment to work with US industry in technology development. &apos;&apos;Managing the Nova Laser Project&apos;&apos; details the organization and close monitoring of costs and schedules during the construction of the Nova laser facility. The article &apos;&apos;Optical Coatings by the Sol-Gel Process,&apos;&apos; describes our chemical process for making the damage-resistant, antireflective silica coatings used on the Nova laser glass. The technical challenges in designing and fabricating the KDP crystal arrays used to convert the light wave frequency of the Nova lasers are reported in &apos;&apos;Frequency Conversion of the Nova Laser.&apos;&apos; Two articles, &apos;&apos;Eliminating Platinum Inclusions in Laser Glass&apos;&apos; and &apos;&apos;Detecting Microscopic Inclusions in Optical Glass,&apos;&apos; describe how we dealt with the problem of damaging metal inclusions in the Nova laser glass. The last article reprinted here, &apos;&apos;Auxilliary Target Chamber for Nova,&apos;&apos; discusses the diversion of two of Nova&apos;s ten beamlines into a secondary chamber for the purpose of increasing our capacity for experimentation.

  11. ApoE isoform-dependent changes in hippocampal synaptic function

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    Sullivan Patrick M

    2009-05-01

    Full Text Available Abstract The lipoprotein receptor system in the hippocampus is intimately involved in the modulation of synaptic transmission and plasticity. The association of specific apoE isoform expression with human neurodegenerative disorders has focused attention on the role of these apoE isoforms in lipoprotein receptor-dependent synaptic modulation. In the present study, we used the apoE2, apoE3 and apoE4 targeted replacement (TR mice along with recombinant human apoE isoforms to determine the role of apoE isoforms in hippocampus area CA1 synaptic function. While synaptic transmission is unaffected by apoE isoform, long-term potentiation (LTP is significantly enhanced in apoE4 TR mice versus apoE2 TR mice. ApoE isoform-dependent differences in LTP induction require NMDA-receptor function, and apoE isoform expression alters activation of both ERK and JNK signal transduction. Acute application of specific apoE isoforms also alters LTP induction while decreasing NMDA-receptor mediated field potentials. Furthermore, acute apoE isoform application does not have the same effects on ERK and JNK activation. These findings demonstrate specific, isoform-dependent effects of human apoE isoforms on adult hippocampus synaptic plasticity and highlight mechanistic differences between chronic apoE isoform expression and acute apoE isoform exposure.

  12. Pressure effects on the intervalence-transfer band of salts of mixed-valence 1&apos;,1&apos;'&apos;-disubstituted biferrocenium cations

    Energy Technology Data Exchange (ETDEWEB)

    Sinha, U.; Lowery, M.D.; Ley, W.W.; Drickamer, H.G.; Hendrickson, D.N.

    1988-04-13

    The pressure dependence of the intervalence-transfer (IT) electronic absorption band has been determined for the mixed-valence biferrocenium and 1&apos;,1&apos;'&apos;-diethylbiferrocenium cations intercalated into a clay and for the following eight microcrystalline compounds: biferrocenium triiodide (1); biferrocenium hexafluorophosphate (2); 1&apos;,1&apos;'&apos;-diiodobiferrocenium triiodide (3); 1&apos;,1&apos;'&apos;-diiodobiferrocenium dibromoiodate (4); 1&apos;,1&apos;'&apos;-dibromobiferrocenium triiodide (5); 1&apos;,1&apos;'&apos;-dichlorobiferrocenium triiodide hemiiodine (6); 1&apos;,1&apos;'&apos;-diethylbiferrocenium triiodide (7); 1&apos;,1&apos;'&apos;-di-n-butylbiferrocenium triiodide (8). Basically three different types of pressure dependencies of the energy of the IT band are seen. Compounds 3-5, which have a solid-state packing arrangement consisting of alternating stacks of cations and anions, exhibit one type of behavior. For these three compounds the IT band shifts blue initially with pressure, and above approx. 80 kbar there is the onset of a rather abrupt reversal where the IT band shifts red with increasing pressure.

  13. &apos;&apos;Black Bone&apos;&apos; MRI: a potential alternative to CT with three-dimensional reconstruction of the craniofacial skeleton in the diagnosis of craniosynostosis

    Energy Technology Data Exchange (ETDEWEB)

    Eley, Karen A. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); University of Cambridge, Addenbrookes Hospital, Department of Radiology, Cambridge (United Kingdom); Watt-Smith, Stephen R. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); University College London, Eastman Dental Institute, London (United Kingdom); Sheerin, Fintan [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom); Oxford University Hospitals NHS Trust, Oxford (United Kingdom); Golding, Stephen J. [University of Oxford, John Radcliffe Hospital, Nuffield Department of Surgical Sciences, Oxford (United Kingdom)

    2014-10-15

    To determine the potential of novel gradient echo parameters, &apos;&apos;Black Bone&apos;&apos; MRI as an alternative to CT in the identification of normal and prematurely fused cranial sutures both in 2D and 3D imaging. Thirteen children with a clinical diagnosis of craniosynostosis underwent &apos;&apos;Black Bone&apos;&apos; MRI in addition to routine cranial CT. &apos;&apos;Black Bone&apos;&apos; datasets were compared to CT and clinical findings. &apos;&apos;Black Bone&apos;&apos; imaging was subsequently used to develop 3D reformats of the craniofacial skeleton to enhance further visualisation of the cranial sutures. Patent cranial sutures were consistently identified on &apos;&apos;Black Bone&apos;&apos; MRI as areas of increased signal intensity. In children with craniosynostosis the affected suture was absent, whilst the remaining patent sutures could be visualised, consistent with CT and clinical findings. Segmentation of the &apos;&apos;Black Bone&apos;&apos; MRI datasets was successful with both threshold and volume rendering techniques. The cranial sutures, where patent, could be visualised throughout their path. Patent cranial sutures appear as areas of increased signal intensity on &apos;&apos;Black Bone&apos;&apos; MRI distinct from the cranial bone, demonstrating considerable clinical potential as a non-ionising alternative to CT in the diagnosis of craniosynostosis. (orig.)

  14. Tratamento nutricional dos transtornos alimentares Nutritional treatment of eating disorders

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    Andréa Romero Latterza

    2004-01-01

    Full Text Available Pacientes com transtornos alimentares possuem inadequações profundas no consumo, padrão e comportamento alimentar, além de diversas crenças equivocadas sobre alimentação, o que geralmente acarreta piora do estado nutricional. O tratamento nutricional visa a reverter tais alterações e promover hábitos alimentares saudáveis e melhor relação para com o alimento. Os objetivos e características do tratamento diferem para a anorexia nervosa e a bulimia nervosa, contudo, usualmente, a abordagem é dividida em duas fases: a educacional, cujas principais metas são a regularização do hábito alimentar e o aumento do conhecimento nutricional, e a experimental, que visa a propiciar maior reabilitação nutricional e mudanças mais profundas no comportamento alimentar. As evidências existentes sugerem que o tratamento nutricional promove a melhora de tais parâmetros, porém, alguns comportamentos alimentares, como a sensação de incompetência ao lidar com os alimentos, permanecem. Desta forma, mais estudos são necessários para que se possa de fato avaliar a eficácia da abordagem nutricional.Patients with eating disorders have disturbed food intake, food pattern, food behavior, and mistaken beliefs about food and nutrition, which can worsen nutritional status. The nutritional treatment aims to revert such alterations and to promote better food habits and relationship with food. The objectives and characteristics of the treatment are different for anorexia nervosa and bulimia nervosa, but usually the approach has two phases: the educational phase, whose major goals are regularization of food habits and increase of nutrition knowledge; and the experimental phase, whose targets are better nutritional rehabilitation and more complex improvements of nutritional behavior. Evidence suggests that nutritional treatment can ameliorate such parameters, but some inadequate food behaviors remain, such as feeling of incompetence while dealing with

  15. Cisto dentígero: modalidades de tratamento

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    Rubens Caliento

    Full Text Available INTRODUÇÃO: O cisto dentígero é o segundo cisto odontogênico mais frequente nos maxilares. É uma lesão benigna, derivada do epitélio odontogênico da coroa de um dente não erupcionado, porém de etiopatogenia incerta. São geralmente radiotransparentes e, mais comumente, uniloculares. Estas lesões são observadas em exames de rotina ou quando não ocorre o irrompimento de um dente permanente. Os terceiros molares inferiores e os caninos superiores são os dentes mais acometidos, sendo também alta a ocorrência desta lesão em dentes supranumerários e associados a odontomas. O cisto dentígero ocorre principalmente nas três primeiras décadas de vida, tendo um crescimento lento e assintomático; pode atingir dimensões consideráveis, causando deformidade facial, impactação e deslocamento de dentes e/ou estruturas adjacentes. OBJETIVO: Definição das técnicas de marsupialização e enucleação, bem como consideração de critérios objetivos importantes para o plano de tratamento, como tamanho do cisto, idade, proximidade com estruturas anatômicas e importância clínica do dente envolvido. Apesar das peculiaridades clínicas de cada caso e do método de tratamento escolhido, o prognóstico destas lesões é favorável, quando se emprega apropriada terapêutica. MATERIAL E MÉTODO: O presente estudo apresentará um relato de caso tratado através da manobra de descompressão seguida de enucleação, bem como uma discussão acerca das modalidades de tratamento. RESULTADO: O paciente encontra-se em pós-operatório de dois anos sem sinais de recidiva da lesão e ausência de parestesias em face. CONCLUSÃO: A técnica empregada preservou a função neurossensorial e mostrou-se eficiente para a cura da lesão.

  16. Response of &apos;Nagpur&apos; mandarin, &apos;Mosambi&apos; sweet orange and &apos;Kagzi&apos; acid lime to gamma radiation

    Energy Technology Data Exchange (ETDEWEB)

    Ladaniya, M.S. E-mail: mslngp@nagpur.dot.net.in; Singh, Shyam; Wadhawan, A.K

    2003-07-01

    The effects of irradiation dose and refrigerated storage conditions on &apos;Nagpur&apos; mandarin (Citrus reticulata Blanco), &apos;Mosambi&apos; sweet orange (Citrus sinensis Osbeck) and &apos;Kagzi&apos; acid lime (Citrus aurantifolia Swingle) were investigated. Mature fruits of these three species were treated with 0, 0.25, 0.5, 1 and 1.5 kGy radiation. &apos;Nagpur&apos; mandarin and &apos;Mosambi&apos; sweet oranges were stored at 6-7 deg. C and 90-95% r.h. for 75 and 90 days, respectively, while &apos;Kagzi&apos; acid limes were stored at 8{+-}1 deg. C and 90-95% r.h. for 90 days. Physico-chemical parameters, sensory attributes and respiration rate were measured besides losses and disorders. In &apos;Nagpur&apos; mandarin, radiation dose upto 1.5 kGy did not cause any rind disorder. Radiation treatments did not reduce the extent of decay. Penicillium rot was delayed in fruit treated with 1.5 kGy, while it appeared early in 0 kGy. Irradiation doses were ineffective to control rots due to Botryodiplodia theobromae and Alternaria citri. Doses upto 1.5 kGy did not cause any significant effect on fruit firmness and juice content; however, total soluble solids increased, while titratable acidity and vitamin &apos;C&apos; content decreased. Texture and flavour scores as recorded after a week, were not affected by irradiation except in 1.5 kGy. In &apos;Mosambi&apos; sweet orange, radiation treatments caused peel disorder in the form of brown sunken areas after 90 days and reduced fruit firmness, acidity and vitamin C content. The TSS content was higher in treated fruit. Flavour and texture were not affected by the doses of irradiation used. In treated acid limes (mature yellow), weight loss and decay were higher than untreated fruit (0 kGy) although difference was non-significant. Juice, TSS, titratable acidity and vitamin C contents were significantly less in treated fruit than in 0 kGy. Texture and flavour scores were also less in treated fruit than in 0 kGy. The

  17. Tratamento nutricional da bulimia nervosa Nutritional therapy for bulimia nervosa

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    Marle dos Santos Alvarenga

    2010-10-01

    Full Text Available A bulimia nervosa é um transtorno alimentar caracterizado por compulsões alimentares e métodos compen-satórios recorrentes. Os pacientes apresentam ingestão alimentar inadequada e comportamentos alimentares disfuncionais. O adequado tratamento do transtorno requer uma equipe multiprofissional e terapia nutricional especializada. Compreender as características desse transtorno, os padrões de consumo e o comportamento alimentar, bem como atentar para as atitudes alimentares dos pacientes, é fundamental para o planejamento e para a adequada condução da abordagem nutricional. A terapia nutricional para esse transtorno é diferenciada, exigindo do nutricionista maiores habilidades de aconselhamento nutricional. Educação nutricional e acon-selhamento nutricional, com ênfase na abordagem de atitudes alimentares e insatisfação corporal, são o foco da terapia nutricional. Para o atendimento eficaz desses pacientes e o sucesso no tratamento nutricional, é importante que o profissional se mantenha atualizado sobre nutrição e transtornos alimentares e procure especialização e experiência nessa área do conhecimento.Bulimia nervosa is an eating disorder characterized by binge eating and compensatory behaviors. The patients present inappropriate food intake and dysfunctional eating behaviors. Proper treatment of this disorder requires a multidisciplinary team and specialized nutrition therapy. It is fundamental to understand the characteristics of this disorder, the intake patterns and the eating behavior, and be attentive to the eating attitudes of these patients to plan and conduct a nutritional approach properly. The nutrition therapy for this disorder is specific and demands greater skillfulness in nutrition counseling from the dietician. Nutrition therapy focuses on nutrition education and nutrition counseling, mainly addressing eating attitudes and dissatisfaction with body image. The professional must keep abreast on nutrition and

  18. Profilaxia para tromboembolia venosa em uma unidade de tratamento intensivo

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    BARRETO SÉRGIO SALDANHA MENNA

    2000-01-01

    Full Text Available Objetivos: Identificar o nível de risco e a prática de profilaxia para TEV em pacientes hospitalizados em um centro de tratamento intensivo (CTI. Métodos: A amostra foi constituída por pacientes admitidos no CTI-HCPA entre dezembro de 1997 e fevereiro de 1998. Foram excluídos pacientes em tratamento com anticoagulantes ou que apresentavam contra-indicações para uso de heparina. Os critérios utilizados para determinação dos fatores de risco para TEV e sua estratificação em níveis de risco seguiram parâmetros estabelecidos em consensos internacionais. O estudo não foi de conhecimento do pessoal médico da unidade. Resultados: Foram analisados 180 pacientes, com média de idade de 58 anos (± 16,5. Os fatores de risco mais freqüentes foram: idade ³ 40 anos (85,0%, grande cirurgia (47,8%, infecção torácica ou abdominal (22,8%. Dois ou mais fatores de risco simultâneos estiveram presentes em 146 (81% casos. Na avaliação do risco para TEV, 142 (79% foram classificados como risco moderado/alto. Medidas profiláticas foram prescritas para 102 pacientes (57%, sendo a heparina utilizada em 60% dos casos de risco moderado ou alto. Evidenciou-se uma associação significativa entre o aumento do nível de risco e do número de fatores de risco com o aumento do uso de profilaxia (p < 0,05. Conclusão: Fatores de risco para TEV foram freqüentes na amostra estudada. No entanto, 40% dos pacientes com risco moderado/alto não receberam profilaxia farmacológica para TEV.

  19. Tratamento cirúrgico da retinopatia diabética

    Directory of Open Access Journals (Sweden)

    Nelson Alexandre Sabrosa

    2013-06-01

    Full Text Available A retinopatia diabética é a causa mais frequente de cegueira na população ativa nos países desenvolvidos. A prevalência da retinopatia diabética aumenta com a duração da diabetes, e praticamente 100% dos pacientes com diabetes tipo I (DM I e mais do que 60% dos pacientes com o tipo II (DM II apresentarão algum sinal de retinopatia após 20 anos. Além de um controle sistêmico rigoroso dos níveis glicêmicos, lipídicos, colesterol e da pressão arterial, o exame oftalmológico de rotina, com a identificação precoce da retinopatia diabética, podem detectar anormalidades em estágios primários, o que possibilita o tratamento ainda na fase inicial do problema; o uso adequado da fotocoagulação e a utilização da terapia antiangiogênica pode reduzir o número de pacientes com hemorragia vítrea ou descolamento tracional da retina. Infelizmente, em vários pacientes, a retinopatia progride mesmo com as melhores condutas tomadas pelo paciente e pelo oftalmologista, embora vários olhos podem se beneficiar com o tratamento cirúrgico, a vitrectomia posterior via pars plana. Esta revisão apresenta as indicações atuais para cirurgia vitreorretiniana em pacientes portadores de retinopatia diabética proliferativa.

  20. Tratamento da doença de Parkinson

    Directory of Open Access Journals (Sweden)

    Francisco Cardoso

    1995-03-01

    Full Text Available Doença de Parkinson (DP é a causa mais freqüente de parkinsonismo em nosso meio, responsável por 58% dos casos. Devem-se excluir outras causas, como uso de drogas antidopaminérgicas (20% dos casos. Levodopa é o agente mais importante para o tratamento de DP. Há controvérsia sobre quando se introduzir esta droga mas deve-se reservá-la para quando surgir substancial comprometimento funcional. Drogas acessórias são anticolinérgicos, úteis para o tremor; amantadina, para bradicinesia e rigidez; e agonistas dopaminérgicos que ajudam no manuseio de complicações da levodopa. A selegelina tem discreta ação sintomática e possível ação neuroprotetora. O tratamento de DP pode ser complicado por falha primária, falha secundária e problemas do uso da levodopa. A falha primária pode ser causada por uso de agentes antidopaminérgicos, presença de tremor de repouso severo ou erro diagnóstico. A causa mais comum de falha secundária é progressão da DP. As principais complicações do uso da levodopa são flutuações e discinesias. Outros problemas comuns são disautonomia, depressão, psicose e demência. Fenomenologia e manuseio destas complicações são discutidos. Perspectivas futuras incluem cirurgias para reversão de patologia.

  1. Tratamento Videolaparoscópico de Endometriomas Ovarianos

    Directory of Open Access Journals (Sweden)

    Lopez Adriana C.S.

    2000-01-01

    Full Text Available Objetivo: avaliar os resultados do tratamento videolaparoscópico de 32 pacientes com endometrioma ovariano. Métodos: estudo retrospectivo que incluiu trinta e duas pacientes encaminhadas ao setor de Endoscopia Ginecológica do Serviço de Ginecologia e Obstetrícia do Hospital do Servidor Público Estadual "Francisco Morato de Oliveira" - São Paulo, as quais tinham diagnóstico clínico e ultra-sonográfico de endometrioma ovariano e foram tratadas por videolaparoscopia. Onze pacientes com endometriomas com diâmetro menor que 3 cm foram submetidas à drenagem do endometrioma e exérese da cápsula na primeira laparoscopia. Vinte e uma pacientes com endometriomas com diâmetros maior que 3 cm foram submetidas à drenagem do endometrioma e lavagem do cisto na primeira laparoscopia. A seguir, utilizaram análogo do GnRH por quatro meses (1 ampola mensal e então foram submetidas à segunda laparoscopia para retirada da cápsula do endometrioma. O exame histopatológico do material obtido na cirurgia foi realizado em todos os casos. Avaliou-se o resultado imediato do procedimento e a freqüência de recidivas. Resultados: não se registraram intercorrências cirúrgicas ou complicações pós-operatórias. Ocorreram três recidivas em um período de seis a doze meses, todas no grupo de 21 pacientes com endometriomas com o diâmetro maior que 3 cm. Conclusão: o tratamento videolaparoscópico dos endometriomas ovarianos com retirada da cápsula apresenta bons resultados e baixo índice de recidiva.

  2. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.

    Science.gov (United States)

    Zhu, Li; Zhong, Minghao; Elder, Gregory A; Sano, Mary; Holtzman, David M; Gandy, Sam; Cardozo, Christopher; Haroutunian, Vahram; Robakis, Nikolaos K; Cai, Dongming

    2015-09-22

    The apolipoprotein E4 (ApoE4) allele is the strongest genetic risk factor for developing sporadic Alzheimer's disease (AD). However, the mechanisms underlying the pathogenic nature of ApoE4 are not well understood. In this study, we have found that ApoE proteins are critical determinants of brain phospholipid homeostasis and that the ApoE4 isoform is dysfunctional in this process. We have found that the levels of phosphoinositol biphosphate (PIP2) are reduced in postmortem human brain tissues of ApoE4 carriers, in the brains of ApoE4 knock-in (KI) mice, and in primary neurons expressing ApoE4 alleles compared with those levels in ApoE3 counterparts. These changes are secondary to increased expression of a PIP2-degrading enzyme, the phosphoinositol phosphatase synaptojanin 1 (synj1), in ApoE4 carriers. Genetic reduction of synj1 in ApoE4 KI mouse models restores PIP2 levels and, more important, rescues AD-related cognitive deficits in these mice. Further studies indicate that ApoE4 behaves similar to ApoE null conditions, which fails to degrade synj1 mRNA efficiently, unlike ApoE3 does. These data suggest a loss of function of ApoE4 genotype. Together, our data uncover a previously unidentified mechanism that links ApoE4-induced phospholipid changes to the pathogenic nature of ApoE4 in AD.

  3. Optimal &apos;'image-based'&apos; weighting for energy-resolved CT

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Taly Gilat [Department of Biomedical Engineering, Marquette University, Milwaukee, Wisconsin 53201 (United States)

    2009-07-15

    This paper investigates a method of reconstructing images from energy-resolved CT data with negligible beam-hardening artifacts and improved contrast-to-nosie ratio (CNR) compared to conventional energy-weighting methods. Conceptually, the investigated method first reconstructs separate images from each energy bin. The final image is a linear combination of the energy-bin images, with the weights chosen to maximize the CNR in the final image. The optimal weight of a particular energy-bin image is derived to be proportional to the contrast-to-noise-variance ratio in that image. The investigated weighting method is referred to as &apos;'image-based'&apos; weighting, although, as will be described, the weights can be calculated and the energy-bin data combined prior to reconstruction. The performance of optimal image-based energy weighting with respect to CNR and beam-hardening artifacts was investigated through simulations and compared to that of energy integrating, photon counting, and previously studied optimal &apos;'projection-based'&apos; energy weighting. Two acquisitions were simulated: dedicated breast CT and a conventional thorax scan. The energy-resolving detector was simulated with five energy bins. Four methods of estimating the optimal weights were investigated, including task-specific and task-independent methods and methods that require a single reconstruction versus multiple reconstructions. Results demonstrated that optimal image-based weighting improved the CNR compared to energy-integrating weighting by factors of 1.15-1.6 depending on the task. Compared to photon-counting weighting, the CNR improvement ranged from 1.0 to 1.3. The CNR improvement factors were comparable to those of projection-based optimal energy weighting. The beam-hardening cupping artifact increased from 5.2% for energy-integrating weighting to 12.8% for optimal projection-based weighting, while optimal image-based weighting reduced the cupping to 0

  4. The &apos;lamellated&apos; skull in. beta. -thalassaemia

    Energy Technology Data Exchange (ETDEWEB)

    Orzincolo, C. (St. Anna Hospital, Ferrara (Italy). Dept. of Radiology); Castaldi, G. (St. Maria delle Croci Hospital, Ravenna (Italy). Dept. of Medicine); Scutellari, P.N. (Ferrara Univ. (Italy). Inst. of Radiology); Franceschini, F. (Ferrara Univ. (Italy). Inst. of Medical Semeiotica)

    1989-08-01

    The skull in homozygous {beta}-thalassaemia may present several abnormalities, such as osteopenia, widening of the diploic space, and a &apos;hair-on-end&apos; appearance. In some cases it presents also a particular stratified appearance caused by a variable number of osseous lamellae, parallel with the inner table. This &apos;lamellated skull&apos; was observed in 16 out of 150 patients affected by the disease (10.6%). (orig./GDG).

  5. The best selled car. &apos;'Twizy'&apos; leads the sales statistics of electrically powered vehicles - a test report; Der Meistverkaufte. Renaults &apos;'Twizy'&apos; fuehrt die E-Mobil-Verkaufsstatistik an - ein Fahrbericht

    Energy Technology Data Exchange (ETDEWEB)

    Welter, Philippe

    2013-02-15

    Four wheels, two seats, one steering wheel: What does it require more for a small, electrically powered city car? Nothing, says the manufacturer. Two side windows, that is our opinion. With a maximum speed of 80 kilometers per hour and a range of 100 kilometers, the vehicle is certainly ideal for many applications over short distances in the city. PHOTON now uses the &apos;'Twizy'&apos; for almost a year, and gained consistently good experiences.

  6. Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.

    Science.gov (United States)

    Huang, Yadong

    2011-08-01

    ApoE4 (apolipoprotein E4) is the major known genetic risk factor for AD (Alzheimer's disease). In most clinical studies, apoE4 carriers account for 65-80% of all AD cases, highlighting the importance of apoE4 in AD pathogenesis. Emerging data suggest that apoE4, with its multiple cellular origins and multiple structural and biophysical properties, contributes to AD in multiple ways either independently or in combination with other factors, such as Aβ (amyloid β-peptide) and tau. Many apoE mouse models have been established to study the mechanisms underlying the pathogenic actions of apoE4. These include transgenic mice expressing different apoE isoforms in neurons or astrocytes, those expressing neurotoxic apoE4 fragments in neurons and human apoE isoform knock-in mice. Since apoE is expressed in different types of cells, including astrocytes and neurons, and in brains under diverse physiological and/or pathophysiological conditions, these apoE mouse models provide unique tools to study the cellular source-dependent roles of apoE isoforms in neurobiology and in the pathogenesis of AD. They also provide useful tools for discovery and development of drugs targeting apoE4's detrimental effects.

  7. Proceedings of the DGMK-conference &apos;Synthesis gas chemistry&apos;. Authors&apos; manuscripts

    Energy Technology Data Exchange (ETDEWEB)

    Hoenicke, D.; Kohlpaintner, C.; Luecke, B.; Reschetilowski, W. [eds.

    2000-07-01

    The main topics of the DGMK-Conference &apos;&apos;Synthesis Gas Chemistry&apos;&apos; were: production of synthesis gas from several educts, new catalysts, Fischer-Tropsch synthesis, hydroformylation, steam reforming and carbonylation.

  8. &apos;Renewable energy potentials of the coal mining sector&apos;; &apos;Regenerative Energiepotenziale des Steinkohlebergbaus&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Eikhoff, Juergen [RAG Aktiengesellschaft, Herne (Germany)

    2012-07-15

    The contribution outlines the &apos;green activities and plans&apos; of the RAG. This may be surprising in a coal mining company but perspectives must be found beyond 2018, when coal production will phase out. (orig./AKB)

  9. Progress Report: DE-FG03-97ER20274, &apos;&apos;Microbial Production of Isoprene&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Ray Fall

    2002-03-13

    We have discovered that microorganisms produce and emit the hydrocarbon isoprene (2-methyl-1,3-butadiene), and have suggested that if isoprene-producing enzymes and their genes can be harnessed, useful hydrocarbon-producing systems might be constructed. The main goal of the proposed work is to establish the biochemical mechanism and regulation of isoprene formation in the bacterial system, Bacillus subtilis. Specific objectives of the proposed work are the following: (A) to characterize the physiological regulation of isoprene formation in B. subtilis; (B) to characterize mutations in B. subtilis 168 that suppress isoprene formation, clone these genes, and determine how isoprene and isoprenoid carbon flow are regulated; and (C) to test &apos;'overflow'&apos; and &apos;'signaling'&apos; models for Bacillus isoprene formation. We are also pursuing the isolation and cloning of B. subtilis isoprene synthase, which we believe may be a regulatory enzyme.

  10. Design and implementation of a &apos;'cheese'&apos; phantom-based Tomotherapy TLD dose intercomparison

    Energy Technology Data Exchange (ETDEWEB)

    Schiefer, Hans; Buchauer, Konrad; Heinze, Simon [Medical Physics Group, Department of Radiation Oncology, St. Gallen (Switzerland); Henke, Guido; Plasswilm, Ludwig [Department of Radiation Oncology, St. Gallen (Switzerland)

    2015-11-15

    The unique beam-delivery technique of Tomotherapy machines (Accuray Inc., Sunnyvale, Calif.) necessitates tailored quality assurance. This requirement also applies to external dose intercomparisons. Therefore, the aim of the 2014 SSRMP (Swiss Society of Radiobiology and Medical Physics) dosimetry intercomparison was to compare two set-ups with different phantoms. A small cylindrical Perspex phantom, which is similar to the IROC phantom (Imaging and Radiation Oncology Core, Houston, Tex.), and the &apos;'cheese'&apos; phantom, which is provided by the Tomotherapy manufacturer to all institutions, were used. The standard calibration plans for the TomoHelical and TomoDirect irradiation techniques were applied. These plans are routinely used for dose output calibration in Tomotherapy institutions. We tested 20 Tomotherapy machines in Germany and Switzerland. The ratio of the measured (D{sub m}) to the calculated (D{sub c}) dose was assessed for both phantoms and irradiation techniques. The D{sub m}/D{sub c} distributions were determined to compare the suitability of the measurement set-ups investigated. The standard deviations of the TLD-measured (thermoluminescent dosimetry) D{sub m}/D{sub c} ratios for the &apos;'cheese'&apos; phantom were 1.9 % for the TomoHelical (19 measurements) and 1.2 % (11 measurements) for the TomoDirect irradiation techniques. The corresponding ratios for the Perspex phantom were 2.8 % (18 measurements) and 1.8 % (11 measurements). Compared with the Perspex phantom-based set-up, the &apos;'cheese'&apos; phantom-based set-up without individual planning was demonstrated to be more suitable for Tomotherapy dose checks. Future SSRMP dosimetry intercomparisons for Tomotherapy machines will therefore be based on the &apos;'cheese'&apos; phantom set-up. (orig.) [German] Die einzigartige Bestrahlungstechnik mit Tomotherapie-Bestrahlungsgeraeten (Accuray Inc., Sunnyvale, CA, USA) erfordert spezifische

  11. &apos;Minergie&apos; as an opportunity for trade; &apos;Minergie&apos; als Chance fuer das Gewerbe

    Energy Technology Data Exchange (ETDEWEB)

    Graf, R.; Buergi, H.; Hotz, R.

    2000-07-01

    This collection of short articles is dedicated to the promotion of the Swiss &apos;Minergie&apos; building standard, covering the following points: &apos;Minergie&apos; - a standard for the future; well-insulated and air-tight - two of the three main &apos;Minergie&apos; requirements; solar collectors as a &apos;Minergie&apos; component; radiators for low-energy-consumption buildings; hot water from the sun on six out of seven days; the &apos;Minergie&apos; module as a factor for success; the &apos;Habitus&apos; ventilation unit - a new Swiss product. The first contribution introduces the &apos;Minergie&apos; Standard. Its application in the building and building technical services trades offers from considerable advantages and opportunities for profit. The Standard, which aims to increase the comfort and reduce the energy consumption of buildings, is introduced and the basic principles involved, including energy usage figures, are discussed. A second contribution describes two of the three main requirements for reaching the &apos;Minergie&apos; Standard, air-tightness and good thermal insulation. The main advantage of the standard - a higher level of comfort - is emphasised and an example is given. The third short article takes a look at the use of thermal solar collectors as a source of heat in &apos;Minergie&apos; buildings. A solution involving a combined solar heating and hot-water supply is discussed. The fourth contribution discusses the use of low-temperature radiators in &apos;Minergie&apos; buildings. Examples are given of heat requirements calculation and the factors involved in dimensioning the radiators are discussed. A fifth article describes a commercially available compact solar hot-water system and discusses questions of solar fraction. Returning to basic aspects, the sixth contribution introduces a labelling system for the various components of a &apos;Minergie&apos; building - such as ventilation units, insulation material, radiators, boilers etc

  12. Absorption-line &apos;'forest'&apos; in quasar spectra, and the structure of the universe

    Energy Technology Data Exchange (ETDEWEB)

    Doroshkevich, A.G.; Muket, J.P.

    1985-05-01

    The &apos;'forest'&apos; of absorption lines observed in the spectrum of distant quasars is interpreted in light of the adiabatic (pancake) theory for the origin and evolution of structure in the universe. The hidden mass might reside in neutrino-like particles (perhaps unstable) having a rest mass of about 60--100 eV. Opportunities for testing the hypothesis observationally are discussed.

  13. Small angle neutron scattering experiments on &apos;&apos;side-on fixed&apos;&apos; liquid crystal polyacrylates

    Energy Technology Data Exchange (ETDEWEB)

    Leroux, N. (Centre de Recherche Paul Pascal, Bordeaux-1 Univ., 33 - Pessac (France)); Keller, P. (Lab. Leon Brillouin, CEA-CNRS/CE Saclay, 91 - Gif-sur-Yvette (France)); Achard, M.F. (Centre de Recherche Paul Pascal, Bordeaux-1 Univ., 33 -Pessac (France)); Noirez, L. (Lab. Leon Brillouin, CEA-CNRS/CE Saclay, 91 -Gif-sur-Yvette (France)); Hardouin, F. (Centre de Recherche Paul Pascal, Bordeaux-1 Univ., 33 - Pessac (France))

    1993-08-01

    Small Angle Neutron Scattering experiments were carried out on liquid crystalline &apos;&apos;side-on fixed&apos;&apos; polyacrylates: we observe that the polymer backbone adopts a prolate conformation in the nematic phase. Such anisotropy of the global backbone is larger for smaller spacer lenght. In every case we measure at low temperatures a large chain extension as previously described in polysiloxanes. (orig.).

  14. 4He2+ and H2+ ion beam separation on &apos;'Sokol'&apos; IBA facility

    International Nuclear Information System (INIS)

    Two separation methods of 4He2+ and H2+ ion beams have been tested on &apos;'Sokol'&apos; IBA facility of NSC KIPT: use of existing beam-bending magnet and electrostatic analyzer, dissociation of H2+ ions when the beam passes through the carbon film. It is shown that these methods allow to decrease essentially the H2+ ion content in the 4He2+ beam.

  15. The solar boat &apos;Midnight sun&apos;; Solelbaaten &apos;Midnight sun&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Kohlstroem, Richard; Fiedler, Frank

    2010-12-15

    The solar boat &apos;Midnight sun&apos; has during the project period been presented and demonstrated at many different events in Sweden. The focus has been on exhibitions for boats, energy and education. There was a great response from visitors but also from various media such as newspapers, radio and television which reported about the solar boat. Solar driven vehicles are a great way to create interest for solar technology. Due to the increased demand for technical improvements and financial efforts we refrained from participating at the solar boat race &apos;Frisian Solar Challenge&apos; in 2010 in Holland. Instead a solar boat for tourist trade at Fraemby Udde in Falun has been designed and built. The boat will be rented to visitors during the summer period. The electrical components are designed for short trips with a travel time between 3-4 hours. The solar boat at Fraemby Udde shows that it is relatively simple to convert an existing boat to a solar driven boat. Fraemby Udde receives many visitors, so the solar boat will be shown and used by a large number of tourists from Sweden and abroad

  16. OBJECTIVE BAYESIAN ANALYSIS OF &apos;'ON/OFF'&apos; MEASUREMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Casadei, Diego, E-mail: diego.casadei@fhnw.ch [Visiting Scientist, Department of Physics and Astronomy, UCL, Gower Street, London WC1E 6BT (United Kingdom)

    2015-01-01

    In high-energy astrophysics, it is common practice to account for the background overlaid with counts from the source of interest with the help of auxiliary measurements carried out by pointing off-source. In this &apos;'on/off'&apos; measurement, one knows the number of photons detected while pointing toward the source, the number of photons collected while pointing away from the source, and how to estimate the background counts in the source region from the flux observed in the auxiliary measurements. For very faint sources, the number of photons detected is so low that the approximations that hold asymptotically are not valid. On the other hand, an analytical solution exists for the Bayesian statistical inference, which is valid at low and high counts. Here we illustrate the objective Bayesian solution based on the reference posterior and compare the result with the approach very recently proposed by Knoetig, and discuss its most delicate points. In addition, we propose to compute the significance of the excess with respect to the background-only expectation with a method that is able to account for any uncertainty on the background and is valid for any photon count. This method is compared to the widely used significance formula by Li and Ma, which is based on asymptotic properties.

  17. Effects of inhomogeneities on apparent cosmological observables: &apos;'fake'&apos; evolving dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Romano, Antonio Enea [Kyoto University, Yukawa Institute for Theoretical Physics, Kyoto (Japan); Universidad de Antioquia, Instituto de Fisica, Medellin (Colombia); National Taiwan University, Leung Center for Cosmology and Particle Astrophysics, Taipei, Taiwan (China); The University of Tokyo, Research Centre for the Early Universe (RESCEU), Graduate School of Science, Tokyo (Japan); Starobinsky, Alexei A. [L. D. Landau Institute for Theoretical Physics, Moscow (Russian Federation); The University of Tokyo, Research Centre for the Early Universe (RESCEU), Graduate School of Science, Tokyo (Japan); Sasaki, Misao [Kyoto University, Yukawa Institute for Theoretical Physics, Kyoto (Japan)

    2012-12-15

    Using the exact Lemaitre-Bondi-Tolman solution with a non-vanishing cosmological constant {Lambda}, we investigate how the presence of a local spherically symmetric inhomogeneity can affect apparent cosmological observables, such as the deceleration parameter or the effective equation of state of dark energy (DE), derived from the luminosity distance under the assumption that the real space-time is exactly homogeneous and isotropic. The presence of a local underdensity is found to produce apparent phantom behavior of DE, while a locally overdense region leads to apparent quintessence behavior. We consider relatively small large scale inhomogeneities which today are not linear and could be seeded by primordial curvature perturbations compatible with CMB bounds. Our study shows how observations in an inhomogeneous {Lambda}CDM universe with initial conditions compatible with the inflationary beginning, if interpreted under the wrong assumption of homogeneity, can lead to the wrong conclusion about the presence of &apos;'fake'&apos; evolving dark energy instead of {Lambda}. (orig.)

  18. Formation and characterisation of solution processed &apos;'pseudo-bilayer'&apos; organic solar cells

    Energy Technology Data Exchange (ETDEWEB)

    Heinemann, Marc Daniel; Ananthanarayanan, Krishnamoorthy; Thummalakunta, L.N.S.A.; Yong, Chian Haw; Luther, Joachim [Singapore National Univ. (SG). Solar Energy Research Inst. of Singapore (SERIS)

    2011-07-01

    The current state of the art solution processed organic photovoltaic (OPV) cells are based on the bulk heterojunction (BHJ) architecture, consisting of an active layer, in which the donor and the acceptor material are dissolved in a common solvent. In this report, we show that by sequential processing of the active components and by subsequent annealing a &apos;'pseudo-bilayer'&apos; can be formed which results in an enhanced nanomorphology for efficient charge generation and extraction. The enhanced nanomorphology arises from the inter-diffusion of the PCBM nanoparticles into a layer of pre-organised polymer P3HT instead of a phase separation that happens at the time of spin-coating and annealing in the case of conventional BHJ devices. To get a further insight into the inter-diffusion process, TOF-SIMS depth profiling and XPS measurements were carried out for different thermal annealing treatments of these pseudo-bilayer devices, which show full inter-diffusion after only seconds of annealing at 140 C. The optimised photovoltaic devices that were fabricated showed an efficiency of 4.1%. (orig.)

  19. &apos;&apos;1/f noise&apos;&apos; in music: Music from 1/f noise

    Energy Technology Data Exchange (ETDEWEB)

    Voss, R.F.; Clarke, J.

    1978-01-01

    The spectral density of fluctuations in the audio power of many musical selections and of English speech varies approximately as 1/f (f is the frequency) down to a frequency of 5 x 10/sup -4/ Hz. This result implies that the audio-power fluctuations are correlated over all times in the same manner as &apos;&apos;1/f noise&apos;&apos; in electronic components. The frequency fluctuations of music also have a 1/f spectral density at frequencies down to the inverse of the length of the piece of music. The frequency fluctuations of English speech have a quite different behavior, with a single characteristic time of about 0.1 s, the average length of a syllable. The observations on music suggest that 1/f noise is a good choice for stochastic composition. Compositions in which the frequency and duration of each note were determined by 1/f noise sources sounded pleasing. Those generated by white-noise sources sounded too random, while those generated by 1/f/sup 2/ noise sounded too correlated.

  20. In vivo imaging of &apos;'neuroinflammation'&apos;. Principles and applications; In-vivo-Darstellung &apos;'neuroinflammatorischer'&apos; Veraenderungen mit [{sup 11}C] PK11195-PET. Grundlagen und Anwendung

    Energy Technology Data Exchange (ETDEWEB)

    Gerhard, A.; Banati, R.B. [MRC Clinical Sciences Centre and Div. of Neuroscience, Faculty of Medicine, Imperial Coll., London (United Kingdom)

    2002-09-01

    Microglia are the brains&apos; resident immunocompetent cells that can be activated by acute as well as chronic pathological stimuli. When activated they express the peripheral benzodiazepine binding site to which the isoquinolin PK11195 binds with high specificity. Labelled with [{sup 11}C], the R-enatiomer [{sup 11}C] PK1195 has been used for positron emission tomography (PET) studies to demonstrate neuroinflammatory changes in vivo. [{sup 11}C](R) PK11195-PET has been successfully used to show in vivo microglial activation in ischemic (stroke), inflammatory (multiple sclerosis) and degenerative (Alzheimer&apos;s and Parkinson&apos;s disease). Longitudinal studies are in progress to help to clarify the relationship between localisation and extent of microglial activation and the clinical presentations in these disorders. This will help to determine the role of [{sup 11}C](R) PK11195 PET as a diagnostic tool and a surrogate marker of &apos;'neuroinflammation'&apos; in therapeutic trials. (orig.) [German] Mikroglia sind residente immunkompetente Zellen des Gehirns, die durch akute, aber auch langsam voranschreitende, chronische Schaedigungprozesse aktiviert werden. Im aktivierten Zustand exprimieren sie den peripheren Benzodiazepinrezeptor, an den das Isoquinolin PK11195 spezifisch bindet. Radioaktiv markiert kann das R-Enantiomer [{sup 11}C] PK11195 als Ligand in der Positronenemissionstomographie (PET) genutzt werden und ermoeglicht so die In-vivo-Darstellung aktiver &apos;'neuroinflammatorischer'&apos;, d.h. die Mikroglia aktivierender, Veraenderungen. Mit der [{sup 11}C](R) PK11195-PET konnte bisher In-vivo-Mikrogliaaktivierung bei ischaemischen (Schlaganfall), entzuendlichen (multiple Sklerose) und degenerativen (Morbus Alzheimer- und Parkinson-Erkrankung) demonstriert werden. Laufende longitudinale Studien werden dazu beitragen, die Beziehung zwischen Lokalisation und Ausmass der Mikrogliaaktivierung und klinischer Krankheitsauspraegung

  1. Internet of &apos;'printed'&apos; Things: low-cost fabrication of autonomous sensing nodes by inkjet printing

    International Nuclear Information System (INIS)

    &apos;&apos;What if electronics devices are printed using an inkjet printer even at home?&apos;&apos; &apos;&apos;What if those devices no longer need a battery?&apos;&apos; I will introduce two enabling technologies for the Internet of Things concept. 1. Instant Inkjet Circuits: A low cost, fast and accessible technology to support the rapid prototyping of electronic devices. We demonstrated that &apos;'sintering-free'&apos; silver nano particle ink with a commodity inkjet printer can be used to fabricate printed circuit board and high-frequency applications such as antennas and sensors. The technology is now commercialized by AgIC, Inc. 2. Wireless Power: Although large amounts of data can be exchanged over a wireless communication link, mobile devices are still tethered by power cables. We are trying to solve this problem by two different approaches: energy harvesting. A simple circuitry comprised of diodes and capacitor can convert ambient radio signals into DC current. Our research revealed the signals from TV tower located 6.5km apart could be used to feed 100 microwatts to power microcontrollers

  2. The atmospheric cycling of radiomethane and the &apos;&apos;fossil fraction&apos;&apos; of the methane source

    Directory of Open Access Journals (Sweden)

    K. R. Lassey

    2006-06-01

    Full Text Available The cycling of 14CH4 (&apos;'radiomethane'&apos; through the atmosphere has been strongly perturbed in the industrial era by the release of 14C-free methane from geologic reservoirs (&apos;&apos;fossil methane&apos;&apos; emissions, and in the nuclear era, especially since ca 1970, by the direct release of nucleogenic radiomethane from nuclear power facilities. Contemporary measurements of atmospheric radiomethane have been used to estimate the proportion of fossil methane in the global methane source (the &apos;&apos;fossil fraction&apos;&apos;, but such estimates carry high uncertainty due to the ill-determined nuclear-power source. We exploit an analysis in a companion paper of the global radiomethane budget through the nuclear era, using contemporary measurements of atmospheric radiomethane since 1986 to quantify both the fossil fraction and the strength of the nuclear power source. We deduce that 28.6±1.9% (1 s.d. of the global methane source has fossil origin, a fraction which may include some 14C-depleted refractory carbon fraction such as in aged peat deposits. The co-estimated strength of the global nuclear-power source of radiomethane is consistent with values inferred independently from local nuclear facilities.

  3. Study and designing of the &apos;'caliprax'&apos; measurement bench; Etude et realisation du banc &apos;'caliprax'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Barriere, J.Ch

    2001-09-01

    Probing the matter in order to check its elementary constituents, that is the goal of the particle physic. In this field, the experiments consist in colliding highly energetic particle beams and observing the new born particles. These observations are based on big particle detectors whose running is dependant on the precise knowledge of their geometry (position of the detection chambers). To achieve this, the detectors are equipped with alignment sensors, which have to be calibrated before. This document describes the study and the making of a calibration bench for the &apos;Praxial&apos; (PRoximity AXIAL) type sensors, and other works related to these sensors. In a first part, we determine and apply a method to set the tools used to fix the sensor stands on the detection chambers. These settings are made with the use of a tridimensional measuring machine. Then, we study the stands themselves. These investigations concern mechanics: positioning quality of the sensors in their stands, bending of the supports due to the tightening. In this part too, the studies are in the field of dimensional metrology. After this, the works are reoriented toward the bench, with the choice of the displacement sensors among two different technologies: optical, with the Rasnik system, and mechanical, with linear probes as LVDT (Linear Variable Differential Transformer). Following the discovery of an ambiguity on the Rasnik system, we go on the tests to understand its behaviour. We introduce the theory of the alignment sensors calibration, which is based on a minimization calculation. The computer programs are explained in a chapter, and in an other, the implementation of the quality assurance procedures. An other part describes the mechanical studies and the problems they cause. Because of a delay onset of the project, we make a model of the bench. This dummy allows us to test every single function of the final bench. With this device, we record manually the first calibration data and

  4. Tratamento de úlceras de estase venosa com bota de unna e carvão ativado

    OpenAIRE

    Francisco Tiago

    1996-01-01

    Neste trabalho descreve-se os resultados obtidos no tratamento das úlceras de estase venosa utilizando bota de unna mais curativo de carvão ativado e prata, em 47 pacientes com idade entre 30 e 80 anos. O tempo de tratamento variou de 2 a 16 semanas, a freqüência média das trocas dos curativos foi a cada 6 dias. Dos 47 pacientes, 87% tiveram suas feridas cicatrizadas, 8,5% não obtiveram sucesso e 4,5% abandonaram o tratamento. As principais vantagens observadas foram: redução do número de cur...

  5. Pré-tratamento anaeróbio de um efluente da indústria alimentar

    OpenAIRE

    Monteiro, Norberto Carlos Oliveira Cruz

    2008-01-01

    O trabalho realizado teve como intuito avaliar a aplicabilidade de um processo biológico anaeróbio como pré-tratamento de um efluente gerado na prensagem de compostos insolúveis de cereais e café de uma fábrica nacional de produtos alimentares. Este efluente devido à sua reduzida biodegradabilidade provoca limitações na eficiência do processo de tratamento biológico aeróbio actualmente existente na ETARI (estação de tratamento de águas residuais industriais). Nesse sentido f...

  6. Carcinoma hepatocelular: parte 2. Tratamento Hepatocelular carcinoma: part 2. Therapy

    Directory of Open Access Journals (Sweden)

    Vinício Paride CONTE

    2000-04-01

    Full Text Available São revisadas as formas de tratamento, particularmente as ressecções cirúrgicas, a quimioembolização arterial e as injeções percutâneas de etanol e de ácido acético. Alguns aspectos relativos à dieta, com particular atenção à aflatoxina B1 e aos retinóides, são abordados quanto ao seu desempenho na etiopatogenia e no tratamento da afecção mais comumente encontrada nos países em desenvolvimento. Em relação ao tratamento, fazem-se considerações também referentes ao uso de octreotide, nitrosaminas e outras drogas. A coagulação intersticial a laser e as drogas de ação antivascular também mereceram abordagem sucinta. O problema do carcinoma hepatocelular precoce e a sua destruição é sinalizado de modo sumário. A quimioprevenção com o uso do interferon alfa recombinante considerado e o transplante de fígado encerram a revisão, antes dos comentários finais.Recent improvements on the therapeutical management of hepatocellular carcinoma are revised with special attention to evaluate the role of surgery for the disease. Considering that definitive surgical intervention is not feasible in most cases because of extreme tumor extension, multiplicity of tumor foci, and associated advanced liver cirrhosis at the time of diagnosis, others forms of treatment are listed, such as transcatheterarterial chemoembolization, percutaneous ethanol and acetic acid injections, and chemotherapy only to a small portion of patients with no indication for standard treatments The emerging role of retinoic acid metabolism blocking agents, was examined and may offer a significant new potential treatment for cancer, inclusive the possibility of combining other anticancer drugs with exogenous retinoids or modulation of endogenous retinoids as a real opportunity to advance our ability to treat or prevent human cancer effectively. Octreotide, nitrosamine and other drugs are analyzed and is concluded that improves survival and is a valuable

  7. Endocardite infecciosa: 12 anos de tratamento cirúrgico

    Directory of Open Access Journals (Sweden)

    ARNONI Antoninho Sanfins

    2000-01-01

    Full Text Available INTRODUÇÃO: A endocardite é uma doença de tratamento difícil e que freqüentemente necessita da participação cirúrgica. CASUÍSTICA E MÉTODOS: Entre janeiro de 1987 e janeiro de 1999, 159 pacientes foram operados em nosso Serviço, sendo 64,7% do sexo masculino. Este grupo apresentou idade média de 39,2 anos (2 a 78 anos, com peso médio de 57,1 kg. O acometimento valvar aórtico foi o mais freqüente (66 pacientes, sendo na valva nativa em 47 casos e em próteses em 19 (8 metálicas e 11 biológicas: a lesão mitral verificou-se em 53 pacientes, sendo mais comum em portadores de prótese (28 biológicas e 2 metálicas. O comprometimento das duas valvas esteve presente em 28 casos. Os demais pacientes eram portadores de defeitos congênitos ou de marcapasso definitivo. A operação foi indicada por refratariedade ao tratamento clínico, insuficiência cardíaca, quadro infeccioso levando a disfunção valvar ou de prótese, vazamento periprotético, ou ainda por arritmia. RESULTADOS: O estudo microbiológico evidenciou maior prevalência de infecção por Streptococcus viridans e Staphilococcus aureus. A operação realizada nos portadores de endocardite infecciosa em valva nativa propiciou a conservação da valva em 3 pacientes do grupo mitral e em 1 do grupo aórtico; nos demais pacientes empregaram-se próteses (a maioria metálica em aórticos e biológica em mitrais. As reoperações foram freqüentes, tendo pacientes com até quarta operação. A lesão congênita responsável pela maioria dos casos foi a comunicação interventricular (3 casos e 4 pacientes apresentavam a endocardite em eletrodo de marcapasso. A mortalidade global foi de 16,3%, com maior incidência em portadores de prótese mitral e aórtica submetidos a reoperação. A presença de abscesso como complicação da endocardite infecciosa verificou-se em 18,2% dos pacientes, utilizando-se pericárdio bovino na reconstrução da maioria, com mortalidade de 17

  8. Asma e Gravidez: Tratamento Hospitalar Asthma and Pregnancy: Hospital Admission

    Directory of Open Access Journals (Sweden)

    Francisco Mauad Filho

    2001-09-01

    Full Text Available Objetivo: avaliar as complicações perinatais decorrentes da associação de asma e gravidez em pacientes que necessitaram hospitalização para controle da crise asmática. Método: análise retrospectiva de 12 casos de asma e gravidez que necessitaram de internação hospitalar e foram assistidos no Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, no período compreendido entre 1992 e 1996. Os parâmetros analisados foram: idade materna, acompanhamento pré-natal, tempo de permanência hospitalar, tratamento instituído, intercorrências gravídicas, idade gestacional ao parto, tipo de parto, peso ao nascer e índice de Apgar. Resultados: das 12 gestantes asmáticas, 7 não haviam iniciado o seguimento pré-natal antes da internação para o tratamento da crise asmática. Três pacientes apresentaram doença hipertensiva específica da gravidez, sendo um dos casos associado a rotura prematura de membranas e corioamnionite e outro associado a descolamento prematuro de placenta. Foram diagnosticados 2 casos de insuficiência placentária, um deles associado a trabalho de parto prematuro e transfusão feto-fetal em gestação gemelar e outro associado a oligoâmnio. Foi detectado 1 caso de oligoâmnio associado a pneumonia materna e óbito fetal e também 1 caso de polidrâmnio. Além disso, ocorreram 2 casos de parto prematuro e 3 recém-nascidos foram considerados pequenos para a idade gestacional. Conclusões: a prevenção das complicações da asma na gravidez deve ser instituída antes mesmo da concepção, enfatizando-se os aspectos educativos da paciente em relação à doença e afastando-se quando possível os fatores desencadeantes das crises, como os alergênios ambientais e o tabagismo. O tratamento deve ser instituído precocemente e a paciente deve ser acompanhada em conjunto pelo obstetra e pelo pneumologista.Purpose: to study perinatal outcome in asthmatic

  9. Sex Differences in Presynaptic Density and Neurogenesis in Middle-Aged ApoE4 and ApoE Knockout Mice

    Directory of Open Access Journals (Sweden)

    A. Rijpma

    2013-01-01

    Full Text Available Atherosclerosis and apolipoprotein E ε4 (APOE4 genotype are risk factors for Alzheimer’s disease (AD and cardiovascular disease (CVD. Sex differences exist in prevalence and manifestation of both diseases. We investigated sex differences respective to aging, focusing on cognitive parameters in apoE4 and apoE knockout (ko mouse models of AD and CVD. Presynaptic density and neurogenesis were investigated immunohistochemically in male and female apoE4, apoE ko, and wild-type mice. Middle-aged female apoE4 mice showed decreased presynaptic density in the inner molecular layer of the dentate gyrus of the hippocampus. Middle-aged female apoE ko mice showed a trend towards increased neurogenesis in the hippocampus compared with wild-type mice. No differences in these parameters could be observed in middle-aged male mice. Specific harmful interactions between apoE4 and estrogen could be responsible for decreased presynaptic density in female apoE4 mice. The trend of increased neurogenesis found in female apoE ko mice supports previous studies suggesting that temporarily increased amount of synaptic contacts and/or neurogenesis is a compensatory mechanism for synaptic failure. To our knowledge, no other studies investigating presynaptic density in aging female apoE4 or apoE ko mice are available. Sex-specific differences between APOE genotypes could account for some sex differences in AD and CVD.

  10. VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina.

    Science.gov (United States)

    Antes, Ran; Salomon-Zimri, Shiran; Beck, Susanne C; Garcia Garrido, Marina; Livnat, Tami; Maharshak, Idit; Kadar, Tamar; Seeliger, Mathias; Weinberger, Dov; Michaelson, Daniel M

    2015-01-01

    Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with neuronal and vascular impairments. Recent findings suggest that retina of apoE4 mice have synaptic and functional impairments. We presently investigated the effects of apoE4 on retinal and choroidal vasculature and the possible role of VEGF in these effects. There were no histological differences between the retinal and choroidal vasculatures of naïve apoE3 and apoE4 mice. In contrast, laserdriven choroidal injury induced higher levels of choroidal neovascularization (CNV) in apoE4 than in apoE3 mice. These effects were associated with an inflammatory response and with activation of the Muller cells and asrocytic markers gluthatione synthetase and GFAP, all of which were more pronounced in the apoE4 mice. CNV also induced a transient increase in the levels of the synaptic markers synaptophysin and PSD95 which were however similar in the apoE4 and apoE3 naive mice. Retinal and choroidal VEGF and apoE levels were lower in naïve apoE4 than in corresponding apoE3 mice. In contrast, VEGF and apoE levels rose more pronouncedly following laser injury in the apoE4 than in apoE3 mice. Taken together, these findings suggest that the apoE4-induced retinal impairments, under basal conditions, may be related to reduced VEGF levels in the eyes of these mice. The hyper-neovascularization in the apoE4 mice might be driven by increased inflammation and the associated surge in VEGF following injury. Retinal and choroidal VEGF and apoE levels were lower in naïve apoE4 than in corresponding apoE3 mice. In contrast, VEGF and apoE levels rose more pronouncedly following laser injury in the apoE4 than in apoE3 mice. Taken together, these findings suggest that the apoE4-induced retinal impairments, under basal conditions, may be related to reduced VEGF levels in the eyes of these mice. The hyper-neovascularization in the apoE4 mice might be driven by increased inflammation

  11. Consenso sobre o tratamento da dependência de nicotina

    Directory of Open Access Journals (Sweden)

    Marques Ana Cecilia P R

    2001-01-01

    Full Text Available Têm sido atribuídas à dependência de nicotina 20% das mortes nos EUA. Estudos têm mostrado que 30% a 50% das pessoas que começam a fumar escalam para um uso problemático. Nos últimos 20 anos, a educação e a persuasão não foram suficientes para promover uma mudança política, cultural e social relacionada ao comportamento de fumar. As intervenções para interromper o uso de tabaco ainda não estão integradas às rotinas dos serviços de saúde no mundo. A falta de estratégias de integração, de tempo disponível para acoplar ações assistenciais mais específicas e mesmo a percepção dos profissionais de saúde de que os tratamentos para a dependência de nicotina são pouco efetivos são algumas das barreiras apontadas. Assim, elaborar um consenso sobre a dependência de nicotina teve como objetivos: ? levantar dados epidemiológicos relevantes relacionados ao uso do tabaco no mundo e no Brasil; ? revisar as ações gerais e centrais da nicotina; ? elaborar um protocolo de triagem mínimo para serviços de atenção primária à saúde; ? recomendar diretrizes básicas de avaliação, diagnóstico e tratamento para todos os níveis de atenção à saúde em relação à dependência de nicotina; ? fornecer sugestões para a abordagem de grupos especiais de pacientes: adolescentes, gestantes, idosos, pacientes em regime de internação, obesos e pacientes com comorbidades psiquiátricas, cardiovasculares e respiratórias.

  12. &apos;&apos;Whither Deterrence?&apos;&apos; A Brief Synopsis May, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Poppe, C; Vergino, E; Barker, R; Brown, P; Gilmartin, T J; Nach, M; Sloss, L

    2002-05-29

    To most audiences, deterrence has been interconnected with nuclear weapons whose purpose had been to deter a Soviet attack. But, the Soviet Union has been gone for almost a decade. President George W. Bush has stated that Russia is not an enemy of the US and the numbers of nuclear weapons can be dramatically reduced. It is important to note that deterrence has always transcended nuclear weapons. The US&apos; first line of deterrence has been its formidable conventional warfare capability, designed to prevent conflict and win wars if necessary. The role of nuclear weapons has been to deter the,use of nuclear weapons and other weapons of mass destruction against U.S. interests during the conduct of conventional warfare and to ensure our ability to inflict massive destruction on any who would use nuclear weapons, or other weapons of mass destruction, against us. With regard to the Soviet Union, the threat of the use of nuclear weapons was a critical component of our deterrent to prevent massive Soviet conventional attack against our allies in Europe. However, the events of September 11, 2001 make clear that we have not convinced all who seek to harm us that we will be able to respond in a manner to make them wish they had not even tried. The September 11 attacks, as well as other past conflicts, do not mean that deterrence has failed-it remains effective against the threats for which it was designed. We have known there are other threats for which we did not have a credible deterrent. The challenge is to sustain deterrence against the classic threats as they evolve in technical sophistication while remaining alert to the need to evaluate continuously our ability to deter previously unforeseen challenges. How then should we be looking at deterrence as we consider fifteen or so years in the future, say to about 2015? What will be the role of nuclear weapons and other instruments of mass destruction in the future? What should the US be doing to prepare for the future? In

  13. &apos;'Routine'&apos; brain CT in psychiatric patients - does it make sense?; &apos;'Routine'&apos;-Schaedel-CT in der psychiatrischen Diagnostik

    Energy Technology Data Exchange (ETDEWEB)

    Pickuth, D.; Heywang-Koebrunner, S.H.; Spielmann, R.P. [Martin-Luther-Universitaet Halle-Wittenberg, Halle (Germany). Klinik und Poliklinik fuer Diagnostische Radiologie

    1999-11-01

    Purpose: To prospectively assess the spectrum of brain CT findings in psychiatric patients and to determine the number of patients that had an underlying cause for the symptoms. Patients and methods: Over a period of six months, 142 patients (78 males, 64 females; median age 61 [18-91] years) were referred for CT brain scans. Their scans were reviewed, along with the clinical information that was provided in the request form. All the hard copies were reviewed to assess areas of ischaemia, infarction, atrophy, tumours, and haematomas. The majority of requests were to exclude vascular event or space-occupying lesions. Clinical indications included mood disorders (depression, mania), schizophrenic disorders, dementia, personality and behavioural disorders. Results: 31 (22%) were normal. 111 (78%) had varying degrees of ischaemia, infarction and cerebral/cerebellar atrophy. 7 (4.9%) had space-occupying lesions which included two gliomas and five meningiomas. There were two chronic subdural haematomas and one arteriovenous malformation. Conclusion: 1. In our series, pathologic findings in &apos;routine&apos; brain CT&apos;s were encountered in 78%. 2. The incidence of brain tumours was 4.9%, compared with 0.00005% of the general population. 3. CT scanning in psychiatric patients is cost-effective and especially indicated when there is an atypical presentation, or inadequate response to standard treatment. (orig.) [German] Hintergrund: Bei psychiatrischen Patienten wird vielerorts routinemaessig eine kraniale Computertomographie (CCT) durchgefuehrt. Ob der Nutzen die Kosten rechtfertigt, wurde im Rahmen einer Prospektivstudie untersucht. Patienten und Methode: In einem Zeitraum von 6 Monaten wurde bei 142 psychiatrischen Patienten (78 Maenner, 64 Frauen, 18-91 Jahre, Median 61 Jahre) ein CCT angefertigt. Die Untersuchung erfolgt nativ in 5-mm-Schichtdicke, bei klinischem Verdacht auf eine intrakraniale Raumforderung auch kontrastverstaerkt. Ueberweisungsdiagnosen waren v

  14. The effect of a high-fat diet on brain plasticity, inflammation and cognition in female ApoE4-knockin and ApoE-knockout mice

    NARCIS (Netherlands)

    C.I.F. Janssen (Carola); D. Jansen (Diane); M.P.C. Mutsaers (Martina); J. Dederen (Jos); B. Geenen (Bram); M. Mulder (Monique); A.J. Kiliaan Kiliaan (Amanda J.)

    2016-01-01

    textabstractApolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protec

  15. Extracellular proteolysis of apolipoprotein E (apoE by secreted serine neuronal protease.

    Directory of Open Access Journals (Sweden)

    Irfan Y Tamboli

    Full Text Available Under normal conditions, brain apolipoprotein E (apoE is secreted and lipidated by astrocytes, then taken up by neurons via receptor mediated endocytosis. Free apoE is either degraded in intraneuronal lysosomal compartments or released. Here we identified a novel way by which apoE undergoes proteolysis in the extracellular space via a secreted neuronal protease. We show that apoE is cleaved in neuronal conditioned media by a secreted serine protease. This apoE cleavage was inhibited by PMSF and α1-antichymotrypsin, but not neuroserpin-1 or inhibitors of thrombin and cathepsin G, supporting its identity as a chymotrypsin like protease. In addition, apoE incubation with purified chymotrypsin produced a similar pattern of apoE fragments. Analysis of apoE fragments by mass spectrometry showed cleavages occurring at the C-terminal side of apoE tryptophan residues, further supporting our identification of cleavage by chymotrypsin like protease. Hippocampal neurons were more efficient in mediating this apoE cleavage than cortical neurons. Proteolysis of apoE4 generated higher levels of low molecular weight fragments compared to apoE3. Primary glial cultures released an inhibitor of this proteolytic activity. Together, these studies reveal novel mechanism by which apoE can be regulated and therefore could be useful in designing apoE directed AD therapeutic approaches.

  16. Tratamento de úlceras de estase venosa com bota de unna e carvão ativado

    Directory of Open Access Journals (Sweden)

    Francisco Tiago

    1996-06-01

    Full Text Available Neste trabalho descreve-se os resultados obtidos no tratamento das úlceras de estase venosa utilizando bota de unna mais curativo de carvão ativado e prata, em 47 pacientes com idade entre 30 e 80 anos. O tempo de tratamento variou de 2 a 16 semanas, a freqüência média das trocas dos curativos foi a cada 6 dias. Dos 47 pacientes, 87% tiveram suas feridas cicatrizadas, 8,5% não obtiveram sucesso e 4,5% abandonaram o tratamento. As principais vantagens observadas foram: redução do número de curativos, economia para o serviço de saúde e pacientes, facilidade da aplicação do tratamento.

  17. Tratamento cirúrgico-ortodôntico dos traumatizados dento-alveolares

    OpenAIRE

    Fernando Peres; Paula Macedo; Fernando R. Rebelo; Pedro Mesquita

    1996-01-01

    Os autores apresentam a sua filosofia sobre este tipo de tratamento, que ilustram com uma série de casos clínicos. The authors present their philosophy of this type of treatment showing some clinical cases.

  18. Tratamento cirúrgico-ortodôntico dos traumatizados dento-alveolares (I Parte)

    OpenAIRE

    Fernando Peres; Paula Macedo; Fernando R. Peres; Pedro Mesquita

    1993-01-01

    Os autores apresentam a sua filosofia sobre este tipo de tratamento, que ilustram com uma série de casos clínicos. The authors present their philosophy of this type of treatment showing some clinical cases.

  19. PROCTOSSIGMOIDECTOMIA VIA PERINEAL NO TRATAMENTO DO PROLAPSO RETAL

    Directory of Open Access Journals (Sweden)

    Bueno R. N.

    2001-01-01

    Full Text Available A técnica cirúrgica mais utilizada no tratamento do prolapso retal é a sacropromontofixação do reto por via abdominal, porém nos últimos anos a proctossigmoidectomia via perineal tem sido retomada como alternativa para pacientes idosos com comorbidades. Revisamos 14 casos operados pela proctossigmoidectomia via perineal (cirurgia de Altemeier, sendo 13 mulheres e 1 homem. Destes pacientes havia 50% de obstipados, 14,2% tinham diarréia crônica e 64,2% eram previamente incontinentes. Idade média de 72,2 anos, 64,2 % com anastomose manual e 35,8% mecânica, além de 42,9% com reparo anal posterior no mesmo tempo operatório. O tempo médio de internação foi de 3,8 dias, não houve complicações imediatas ou precoces e apenas ocorreu recidiva em 01 paciente, 7,1%. Pelos bons resultados, baixa morbi-mortalidade e recidiva aceitável e de acordo com a literatura nos encorajamos à utilização desta técnica para correção do prolapso retal .

  20. SHORT GAMMA-RAY BURSTS IN THE &apos;'TIME-REVERSAL'&apos; SCENARIO

    Energy Technology Data Exchange (ETDEWEB)

    Ciolfi, Riccardo [Physics Department, University of Trento, Via Sommarive 14, I-38123 Trento (Italy); Siegel, Daniel M., E-mail: riccardo.ciolfi@unitn.it, E-mail: daniel.siegel@aei.mpg.de [Max Planck Institute for Gravitational Physics (Albert Einstein Institute), Am Mühlenberg 1, D-14476 Potsdam-Golm (Germany)

    2015-01-10

    Short gamma-ray bursts (SGRBs) are among the most luminous explosions in the universe and their origin still remains uncertain. Observational evidence favors the association with binary neutron star or neutron star-black hole (NS-BH) binary mergers. Leading models relate SGRBs to a relativistic jet launched by the BH-torus system resulting from the merger. However, recent observations have revealed a large fraction of SGRB events accompanied by X-ray afterglows with durations ∼10{sup 2}-10{sup 5} s, suggesting continuous energy injection from a long-lived central engine, which is incompatible with the short (≲ 1 s) accretion timescale of a BH-torus system. The formation of a supramassive NS, resisting the collapse on much longer spin-down timescales, can explain these afterglow durations, but leaves serious doubts on whether a relativistic jet can be launched at the merger. Here we present a novel scenario accommodating both aspects, where the SGRB is produced after the collapse of a supramassive NS. Early differential rotation and subsequent spin-down emission generate an optically thick environment around the NS consisting of a photon-pair nebula and an outer shell of baryon-loaded ejecta. While the jet easily drills through this environment, spin-down radiation diffuses outward on much longer timescales and accumulates a delay that allows the SGRB to be observed before (part of) the long-lasting X-ray signal. By analyzing diffusion timescales for a wide range of physical parameters, we find delays that can generally reach ∼10{sup 5} s, compatible with observations. The success of this fundamental test makes this &apos;'time-reversal'&apos; scenario an attractive alternative to current SGRB models.

  1. The trochlear cleft: the &apos;&apos;black line&apos;&apos; of the trochlear trough

    Energy Technology Data Exchange (ETDEWEB)

    Wissman, Robert D.; Nepute, Joshua; Fischer, Nathaniel von; Radhakrishnan, Rupa; Hendry, Daniel [University of Cincinnati Medical Center, Department of Radiology, Cincinnati, OH (United States); Ingalls, Jerrell [Desert Radiologists, Las Vegas, NV (United States); Kenter, Keith [University of Cincinnati Medical Center, Department of Orthopaedic Surgery, Cincinnati, OH (United States)

    2012-09-15

    The &apos;&apos;cartilage black line sign&apos;&apos; is a recently described T2 dark cartilage lesion that we have identified appearing as a cleft in the trochlear trough. The purpose of our study was to define the MR imaging characteristics of a trochlear cleft, determine its incidence, and correlate the MR findings with arthroscopy. A total of 1,300 consecutive MR examinations of the knee were retrospectively reviewed by consensus of two fellowship-trained musculoskeletal radiologists. The MR imaging characteristics and location of a trochlear cleft were determined. Imaging results were compared to arthroscopy when available. Patient age and gender were compared to 25 randomly selected control patients without trochlear clefts. A total of 25 (1.9%) individuals (11 females and 14 males; age range 19-45 years; mean age 28 years) were diagnosed with a trochlear cleft. The control group consisted of 11 females and 14 males; age range 19-83 years; mean age 46 years. Mean cleft length was 7 mm (range 6-12 mm); cleft location was consistently in the lower trochlear trough. No full-thickness cartilage defects were identified in the eight individuals in whom arthroscopic correlation was available. A grade 2 cartilage lesion was identified in a single individual; another progressed from grade 0 to a full-thickness trochlear lesion over an 8-month interval. Eight individuals were athletes. No significant difference in gender was noted between the two groups, however, the study group was significantly younger p < 0.0001. A trochlear cleft is a rare finding in young active individuals. It most likely indicates an incomplete cartilage fissure which may rarely progress to a full-thickness defect. (orig.)

  2. &apos;&apos;Atomic Optics&apos;&apos;: Nonimaging Optics on the Nanoscale

    Energy Technology Data Exchange (ETDEWEB)

    Roland Winston Joseph O' Gallagher

    2005-01-15

    This is the final report for a one year close out extension of our basic research program that was established at the University of Chicago more than sixteen years ago to explore and develop the optical sub-discipline that has come to be known as &apos;&apos;nonimaging optics&apos;&apos;. This program has been extremely fruitful, having both broadened the range of formalism available for workers in this field and led to the discovery of many new families of optical devices. These devices and techniques have applications wherever the efficient transport and transformation of light distributions are important, in particular in illumination, fiber optics, collection and concentration of sunlight, and the detection of faint light signals in physics and astrophysics. Over the past thirty years, Nonimaging Optics (Welford and Winston, 1989) has brought a fresh approach to the analysis of many problems in classical macro-scale optics. Through the application of phase-space concepts, statistical methods, thermodynamic arguments, etc., many previously established performance limits were able to be broken and many technical surprises with exciting practical applications were discovered. The most recent three-year phase of our long-term continuing program ended in late 2002 and emphasized extending our work in geometrical optics and expanding it to include some interesting questions in physical optics as well as in the new field of statistical optics. This report presents a survey of the basic history and concepts of nonimaging optics and reviews highlights and significant accomplishments over the past fifteen years. This is followed by a more detailed summary of recent research directions and accomplishments during the last three years. This most recent phase was marked by the broadening in scope to include a separate project involving a collaboration with an industrial partner, Science Applications International Corporation (SAIC). This effort was proposed and approved in

  3. The adductor magnus &apos;'mini-hamstring'&apos;: MRI appearance and potential pitfalls

    Energy Technology Data Exchange (ETDEWEB)

    Broski, Stephen M.; Murthy, Naveen S.; Collins, Mark S. [Department of Radiology, Mayo Clinic, Rochester, MN (United States); Krych, Aaron J. [Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN (United States); Obey, Mitchel R. [Mayo School of Graduate Medical Education, Rochester, MN (United States)

    2016-02-15

    To examine the anatomic MRI characteristics of the adductor magnus mini hamstring (AMMH) and explore its involvement in cases of hamstring avulsion. An IRB-approved retrospective review of patients undergoing &apos;&apos;hamstring protocol&apos;&apos; MRI between March 2009 and June 2014 was performed. Two musculoskeletal radiologists recorded multiple AMMH anatomic characteristics and involvement in cases of hamstring avulsion. Seventy-six AMMHs were analyzed in 66 patients [35 females and 31 males, mean age 49.3 ± 15.2 years (range 17-81)]. Eleven percent of AMMHs were poorly visualized, 51 % visualized, and 37 % well visualized. Seven percent demonstrated round, 73 % ovoid, and 21 % flat/lenticular tendon morphologies. Most (88 %) demonstrated typical origins. Average cross-sectional area (CSA) was 22.4 ± 10.6 mm{sup 2} (range 6-56), diameter was 7.2 ± 2.5 mm (range 2.9-15), medial distance from the semimembranosus tendon was 7.5 ± 2.5 mm (range 3-14), and tendon length was 6.8 ± 3.3 cm (range 1.2-14.1). There was no gender difference in AMMH anatomic measurements or correlation between age and CSA or diameter. Of 17 complete hamstring avulsion cases, the AMMH was intact in 13, partially torn in 3, and completely torn in 1. The AMMH is a constant finding with variable anatomic characteristics. It is visualized or well visualized by MRI in 88 % of cases and is a sizable tendon located in close proximity to the semimembranosus tendon. Because it is uncommonly completely torn (6 %) in cases of complete hamstring avulsion, radiologists should be aware of its presence and appearance to avoid diagnostic confusion. (orig.)

  4. Tratamento farmacológico de transtornos alimentares Pharmacological treatment of eating disorders

    OpenAIRE

    Fábio Tapia Salzano; Táki Athanássios Cordás

    2004-01-01

    Os autores revisaram a literatura a respeito do tratamento farmacológico para transtornos alimentares, incluindo anorexia nervosa, bulimia nervosa e transtorno da compulsão alimentar periódica. São apresentadas evidências clínicas relacionadas ao uso de psicofármacos nos transtornos alimentares e apontadas, ainda, as perspectivas futuras para o tratamento.The authors have revised the literature about the pharmacological treatment of eating disorders, including anorexia nervosa, bulimia nervos...

  5. Report of working committee 3 &apos;&apos;liquefied gases&apos;&apos;; Rapport du comite de travail 3 &apos;&apos;gaz liquefies&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Baudino, M.

    2000-07-01

    Working Committee 3&apos;s report concerns the evolution of the liquefied gas industry: both liquefied natural gas (LNG) and liquefied petroleum gases (LPG). Given the current state of the LNG market the Committee decided to concentrate on this area in particular. A number of aspects have been identified which the Committee has been looking at, while others have been given to Study Groups set up specifically for the purpose. The first aspects regard: - the development of LNG and LPG, new installations, future chains and relevant statistical data; - the role of LNG and LPG in starting up a gas industry; - operating and technological improvements in the LNG industry; - energy savings, cold utilization and reduction of CO{sub 2} emissions. The Study Groups which were set up dealt with the following subjects: Technological and Economical Developments for cost Reduction of LNG/LPG Facilities. Small Scale LNG Projects and Modular Systems. LNG/LPG Peak Shaving and Satellite Plants. LNG versus Pipeline Infrastructure. (author)

  6. &apos;Fail-to-safety&apos; methane drainage system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-01-01

    Queensland-based Capricorn Coal Management and SMC Pneumatics (Australia) have developed a new methane drainage system incorporating a pneumatically controlled &apos;automatic shut down system&apos; (ASDS) that, in an emergency situation, automatically terminates the flow of gas at the source with automatic shut-off valves. The air supply unit incorporates two air compressors operating in a rotating cycle to ensure continuous supply with pressure and flow measurement sensors and solenoid valves configured to &apos;fail-to-safety&apos; in the event of power failure. The SMC-Capcoal system has been operating successfully for two years at Capcoal&apos;s Central colliery, Queensland&apos;s first longwall mine. It can shut off methane flows within 90 seconds. 3 photos.

  7. The &apos;Instrumental&apos; Reality of Phlogiston

    Directory of Open Access Journals (Sweden)

    Mi Gyung Kim

    2008-07-01

    Full Text Available The stability of phlogiston in eighteenth-century French chemistry depended not on its role as a comprehensive theory, but on its operational (instrumental, theoretical, and philosophical (speculative identities that were forged in different contexts, yet were interwoven to designate a single substance. It was as &apos;real&apos; as any other chemical substance to the degree that it was obtained through material operations, occupied a place in the theoretical edifice of the affinity table, and was endowed with a corpuscular ontology. Lavoisier labeled it as an &apos;imaginary&apos; substance because it offered a unique resistance to his vision of the new chemistry based on &apos;metric&apos; measurements and algebraic representations.

  8. &apos;Action 2016&apos;: AREVA&apos;s strategic action plan; AREVA presente son Plan d&apos;Actions Strategique &apos;Action 2016&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Marie, Patricia; Briand, Pauline; Floquet-Daubigeon, Fleur; Michaut, Maxime; De Scorbiac, Marie; Du Repaire, Philippine

    2011-12-13

    On December 13, 2011, Luc Oursel, CEO, and Pierre Aubouin, Chief Financial Officer presented the group&apos;s strategic plan for the period 2012-2016. The plan has been drawn up collectively and is based on a thorough-going analysis and a realistic assessment of perspectives for all group activities and associated resources. Development of nuclear and renewable energies: the fundamentals are unchanged. In this context, the German decision remains an isolated case and the great majority of nuclear programs around the world have been confirmed. More conservative in its projections than the International Energy Agency, the group expects growth of 2.2% annually, reaching 583 GW of installed nuclear capacity by 2030, against 378 GW today. However, the Fukushima accident will lead to delays in launching new programs. &apos;Action 2016&apos; plan aims to consolidate AREVA&apos;s leadership in nuclear energy and become a leading player in renewable energy. The group&apos;s strategic action plan &apos;Action 2016&apos; is based on the following strategic choices: - commercial priority given to value creation, - selectivity in investments, - strengthening of the financial structure. These demand an improvement in the group&apos;s performance by 2015. This plan makes nuclear safety a strategic priority for the industrial and commercial performance of the group. This ambitious performance plan for the period 2012-2016 will give the group the wherewithal to withstand a temporary slowdown in the market resulting from the Fukushima accident and to deliver safe and sustainable growth of the business. The plan sets out the strategic direction for the group&apos;s employees for the years ahead: taking advantage of the expected growth in nuclear and renewable energies, targeted investment programs, and return to self-financing as of 2014

  9. &apos;&apos;Rueckbau 2014&apos;&apos;. KWS Congress regarding decommissioning and dismantling at Zwentendorf nuclear training power plant; &apos;&apos;Rueckbau 2014&apos;&apos;. KWS-Rueckbau-Fachtagung im Schulungskernkraftwerk Zwentendorf

    Energy Technology Data Exchange (ETDEWEB)

    Maassen, Herbert [KRAFTWERKSSCHULE E.V. (KWS), Essen (Germany)

    2015-06-01

    From September 24 to 25, 2014, KRAFTWERKS-SCHULE E.V. (KWS) held the congress &apos;&apos;Rueckbau 2014&apos;&apos;.This first congress about nuclear power plant decommissioning was combined with an exhibition in the fully equipped Zwentendorf nuclear training power plant. The exhibitors had the opportunity to present and test their products in the ambience of a real nuclear power plant, close to original plant components. The visitors got a general overview of the on-site conditions. During the lectures the process of decommissioning and dismantling of a nuclear power plant were described, problems within this process were discussed, and possible solutions were recommended.

  10. Quantifying the &apos;naturalness&apos; of the curvaton model

    Energy Technology Data Exchange (ETDEWEB)

    Lerner, Rose N. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Helsinki Institute of Physics (Finland); Melville, Scott [Helsinki Institute of Physics (Finland)

    2014-02-15

    We investigate the probability of obtaining an observable curvature perturbation, using as an example the minimal curvaton-Higgs (MCH) model. We determine &apos;probably observable&apos; and &apos;probably excluded&apos; regions of parameter space assuming generic initial conditions and applying a stochastic approach for the curvaton&apos;s evolution during inflation. Inflation is assumed to last longer than the N{sub obs}≅55 observable e-folds, and the total number of e-folds of inflation determines the particular ranges of parameters that are probable. For the MCH model, these &apos;probably observable&apos; regions always lie within the range 8 x 10{sup 4} GeV≤m{sub σ}≤2 x 10{sup 7} GeV, where m{sub σ} is the curvaton mass, and the Hubble scale at horizon exit is chosen as H{sub *}=10{sup 10} GeV. Because the &apos;probably observable&apos; region depends on the total duration of inflation, information on parameters in the Lagrangian from particle physics and from precision CMB observables can therefore provide information about the total duration of inflation, not just the last N{sub obs} e-folds. This method could also be applied to any model that contains additional scalar fields to determine the probability that these scalar fields contribute to the curvature perturbation.

  11. Tratamento da arterite de Takayasu Takayasu’s arteritis treatment

    Directory of Open Access Journals (Sweden)

    Alexandre Wagner Silva de Souza

    2006-06-01

    Full Text Available A arterite de Takayasu (AT é uma vasculite granulomatosa crônica que envolve a aorta e seus principais ramos. A monitoração da atividade da doença e o melhor esquema terapêutico ainda têm sido um desafio para todos os que tratam estes pacientes. Corticosteróides e imunossupressores vêm sendo utilizados na prática clínica diária com resultados nem sempre animadores. Apesar de não haver estudos controlados que abordem o tratamento da AT, diferentes estudos observacionais descrevem a resposta de pacientes com AT ao uso de corticosteróides, metotrexato (MTX, azatio-prina e ciclofosfamida. Após a introdução da terapia biológica, novas perspectivas têm surgido para os pacientes com AT refratários aos esquemas terapêuticos tradicionais.Takayasus’s arteritis is a chronic granulomatous vasculitis involving the aorta and its main branches. Monitoring disease activity and the choice for the best therapy has been major challenger faced by all physicians who treat these patients. Corticosteroids and immunosuppressive therapy have been used in daily medical practice, but results have not always been encouraging. Although there are no controlled studies evaluating the treatment of Takayasu’s arteritis, observational studies have described the response to the use of corticosteroids, methotrexate, azathioprine and cyclophosphamide. The emerging of biological therapy has brought new perspective for Takayasu’s patients who are refractory to conventional therapy.

  12. Tratamento cirúrgico da cisticircose da fossa craniana posterior

    Directory of Open Access Journals (Sweden)

    Pedro Garcia Lopes

    1971-03-01

    Full Text Available A cisticercose, um dos mais sérios problemas parasitológicos do sistema nervoso, apresenta, quando localizada na fossa posterior, um quadro clínico dramático, no qual predomina a hipertensão intracraniana. Foram estudados neste trabalho, 70 pacientes com cisticercose de fossa craniana posterior, atendidos no Serviço de Neurocirurgia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo de 1945 a 1968. Considerando-se a grande diversidade existente em torno das técnicas de tratamento cirúrgico, foi objetivo deste trabalho o estudo dos resultados obtidos nestes pacientes, nos quais várias técnicas foram empregadas. As cirurgias paliativas que derivam o trânsito do líquido cefalorraqueano para regiões extracranianas, quando comparadas aos outros tipos de cirurgias utilizados, foram as que proporcionaram maior índice de recuperação, exigiram menos reoperações, além de terem sido acompanhadas de menor número de complicações, bem como de menor mortalidade pós-operatória. Por outro lado, a neurocisticercose geralmente é um processo difuso, encontrando-se parasitas em várias regiões do encéfalo e/ou aracnoidite, conforme comprovou-se, também, entre os casos ora reunidos e que vieram a falecer. Baseando-se nestes fatos, não se justificam as derivações intracranianas e, a não ser eventualmente, a abordagem direta do parasita. Os casos estudados permitem cone- tatar, portanto, que as derivações extracranianas, por sua simplicidade e eficácia, apresentam-se, atualmente, como a terapêutica cirúrgica mais propriada à cisticercose de fossa craniana posterior.

  13. Intervalos entre tratamentos inseticidas Interval between insecticide treatments

    Directory of Open Access Journals (Sweden)

    Luiz O. T. Mendes

    1959-01-01

    Full Text Available Admitindo que as populações de insetos crescem segundo a lei logística, o autor, partindo de uma equação que a descreve, apresenta uma fórmula que permite estabelecer o intervalo de tempo que deve decorrer entre os tratamentos inseticidas, para que a infestação por uma praga não exceda um limite pré-estabelecido. O valor de t (intervalo, expresso em número de gerações do inseto depende do potencial biótico da espécie, da eficiência do inseticida e do nível de infestação que se estabelecer como máximo permissível. Os resultados teóricos são discutidos e mostram a possibilidade de sua comprovação por meio de populações de insetos mantidas em laboratório, como fase preliminar à sua aplicação no campo.Based on the assumption that the growth of insect populations follows the logistic law, the author developed an equation for the determination of the time interval between insecticide treatments: t= {lpg [100-Po (1-E / (1 - E (100 -Po]} / log p where t = time interval between treatments expressed in number of generations of the species; Po = maximum percentage of infestation, that must not be surpassed (from 0,00 to 100,00; E = efficiency of the insecticide (from 0,00 to 1,00; p = reproduction potential of the species. The theoretical results are discussed.

  14. Tratamento atual dos miomas Current treatment of leiomyomas

    Directory of Open Access Journals (Sweden)

    Helena von Eye Corleta

    2007-06-01

    Full Text Available Leiomiomas são tumores benignos. Eles surgem no miométrio e contêm quantidade variável de tecido conjuntivo fibroso. Cerca de 75% dos casos são assintomáticos, encontrados ocasionalmente durante exame abdominal, pélvico bimanual ou ultra-sonografia. Os sintomas são relacionados diretamente ao tamanho, ao número e à localização dos miomas. Nessa revisão, são apresentadas as abordagens terapêuticas atuais clínicas (anticoncepcionais orais, progestágenos e antiprogestágenos, análogos do hormônio liberador das gonadotrofinas (GnRH, e antiinflamatórios não esteróides e cirúrgicas (histerectomia, miomectomia e embolização para o tratamento de leiomiomas.Leiomyomas are benign tumors. They appear in the myometrium and present a variable amount of fibrous conjunctive tissue. About 75% of the cases are not symptomatic and are usually found during abdominal, bimanual pelvic examination or during ultrasonography. The symptoms are directly related to the size, number and localization of the myomas. In the present review, the current clinical therapeutic procedures (oral anti-conceptive drugs, progestins and anti-progestins, analogues of the gonadothrophins’ releasing hormone (GnRH, and non-steroid anti-inflammatory drugs, and also the surgical procedures (hysterectomy, myomectomy, embolization are presented for the treatment of leiomyomas.

  15. Laser de diodo no tratamento da retinopatia da prematuridade

    Directory of Open Access Journals (Sweden)

    Liarth Josilene de Carvalho Soares

    2001-01-01

    Full Text Available Objetivo: Determinar a eficácia do laser de diodo e suas complicações no tratamento da retinopatia da prematuridade, estágio 3 limiar. Métodos: De 348 crianças pré-termo examinadas na Clínica Oftalmológica do Hospital Getúlio Vargas e Instituto de Olhos do Piauí, em Teresina, Piauí, no período de julho/89 a março/99, 152 (43,7% apresentaram retinopatia da prematuridade. As crianças com retinopatia da prematuridade no estágio 3 limiar foram submetidas a laserablação retiniana com laser de diodo indireto, no centro cirúrgico, sob anestesia geral. Resultados: Vinte crianças (38 olhos foram submetidas a laserablação retiniana. Doze pacientes (80,0% tiveram regressão da retinopatia e três (20,0% evoluíram para o estágio 5. Cinco crianças não retornaram para controle, sendo excluídas do estudo quanto aos resultados do laser. Não foram observadas complicações oculares. Cinco crianças apresentaram apnéia relacionada à anestesia. Conclusões: Neste grupo de crianças, o laser de diodo foi eficaz em 80,0% dos pacientes tratados. As complicações encontradas (cinco casos de apnéia se relacionaram possivelmente à anestesia geral.

  16. An Anti-apoE4 Specific Monoclonal Antibody Counteracts the Pathological Effects of apoE4 In Vivo.

    Science.gov (United States)

    Luz, Ishai; Liraz, Ori; Michaelson, Daniel M

    2016-06-01

    ApolipoproteinE4 (apoE4) is the most prevalent genetic risk factor for Alzheimer's disease (AD) and as such is a promising therapeutic target. This study examined the extent to which the pathological effects of apoE4 can be counteracted in vivo utilizing an immunological approach in which anti-apoE4 antibodies are applied peripherally by i.p. injections into apoE4-targeted replacement mice. Prerequisites for the successful pursuit of this objective are the availability of antibodies that specifically bind brain apoE4 and not apoE3, and demonstrating that direct application of these antibodies into the brain can counteract the effects of apoE4. Accordingly, it was shown that the antiapoE4 monoclonal antibody (mAb) 9D11 binds specifically to brain apoE4 and not apoE3. Direct i.c.v. application of mAb 9D11 prevented the apoE4-driven accumulation of Aβ in hippocampal neurons following activation of the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin. These findings provide a proof-of-concept that anti-apoE4 mAb 9D11, when introduced into the brain, can counteract the apoE4 effects in vivo. Subsequent experiments, utilizing repeated i.p. injections of mAb 9D11, resulted in the formation of apoE/IgG complexes specifically in apoE4 mice. This was associated with reversal of the cognitive impairments of apoE4 in the Morris water maze and the novel object recognition test as well as with reversal of key apoE4-driven pathologies including the hyperphosphorylated tau and the reduced levels of the apoER2 receptor. These results indicate that anti-apoE4 immunotherapy counteracts the cognitive and brain pathological effects of apoE4, and suggest that such an approach could also benefit human apoE4 carriers.

  17. Maintain levels of nicotine but reduce other smoke constituents: a formula for &apos;'less-hazardous'&apos; cigarettes

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, J.C.; Young, J.C.; Rickert, W.S.

    1984-09-01

    Twenty-two volunteers who smoked more than 20 cigarettes with &apos;'high'&apos; nicotine yields (0.8 to 1.2 mg) per day participated in an 8-week study designed to test the hypothesis that smoking cigarettes with a constant level of nicotine but reduced deliveries of tar, carbon monoxide, and hydrogen cyanide leads to a decrease in smoke absorption. All subjects smoked their usual high-nicotine brand for the first 3 weeks (P1), and the absorption of smoke constituents was determined from levels of thiocyanate and cotinine in saliva and serum, levels of carbon monoxide in expired air, and levels of carboxyhemoglobin in the blood. During the final 5 weeks (P2), the treatment group (16 subjects) switched to the &apos;'light'&apos; version of their usual brands (similar yields of nicotine but with reduced yields of tar, carbon monoxide, and hydrogen cyanide); the control group (6 subjects) smoked their usual brands for the duration of the study. Average levels of cotinine for the subjects who switched during P2 were not significantly different from those of the control group as was expected. Slight reductions were noted in average expired-air carbon monoxide levels, blood carboxyhemoglobin, and saliva thiocyanate, but these reductions were smaller than anticipated based on brand characteristics. The results suggest that the ratio of smoke constituents is different when individuals, rather than machines, smoke cigarettes. Yields determined under subject-defined conditions are necessary in order to properly evaluate the role of nicotine in the design of &apos;'less-hazardous'&apos; cigarettes.

  18. Electrolyzed-water generator &apos;SaniBoy&apos;; Eisei jokinsuik kyokyu sochi &apos;SaniBoy&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Inoue, M.; Kakiuchi, H.; Muto, K. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-03-10

    In the food industry, injuries due to food poisoning have been increasing. Especially the mass outbreak of food poisoning by Escherichia coli such as O-157 in 1996 gave warning on the importance of food sanitation management. Public efforts such as the Hazard Analysis and Critical Control Point (HACCP) system have been made to prevent food poisoning. Recently, disinfection made by electrolyzing water with some salt added has attracted attention. Fuji Electric has developed the generator &apos;SaniBoy&apos; that produces weak alkaline electrolyzed water without wasting water. The environment-friendly &apos;SaniBoy&apos; will contribute to sanitation in various fields. (author)

  19. &apos;'Key'&apos; sectors in final energy consumption: an input-output application to the Spanish case

    Energy Technology Data Exchange (ETDEWEB)

    Alcantara, V.; Padilla, E. [Universitat Autonoma de Barcelona, Bellaterra (Spain). Dept. d' Economia Aplicada

    2003-12-01

    In this paper we analyze the determination of &apos;'key'&apos; sectors in the final energy consumption. We approach this issue from an input-output perspective and we design a methodology based on the elasticities of the demands of final energy consumption. As an exercise, we apply the proposed methodology to the Spanish economy. The analysis allows us to indicate the greater or lesser relevance of the different sectors in the consumption of final energy, pointing out which sectors deserve greater,attention in the Spanish case and showing the implications for energy policy. (author)

  20. Marketing manufactured housing under the &apos;&apos;Super Good Cents&apos;&apos; Program

    Energy Technology Data Exchange (ETDEWEB)

    Mohler, B.L.; Smith, S.A.

    1986-01-01

    The objective of this study is to propose a strategy for including manufactured housing (MH) in Bonneville Power Administration&apos;s Super Good Cents (SGC) Program. This report presents information on the site-built SGC program, the characterization of MH consumers, the options for including MH in the SGC program, and the recommendations for including MHs in the SGC program. The purposed strategy for including MHs in the SGC program is designed to reduce risks to manufacturers and dealers, stimulate demand, and allow for maximum flexibility.

  1. Radiobiological study of the radioprotective activity of a natural Iranian compound, &apos;'Shir-Khecht'&apos;; Etude radiobiologique de l&apos;activite radioprotectrice d&apos;un compose naturel Iranien: le &apos;'Shir-Khecht'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rouhanizadeh, N. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-01-01

    After reviewing the primary mechanisms of the action of ionizing radiation, the possible mechanisms of the action of radioprotective substances, the various chemical structures having a protective effect and the methods for studying chemical radioprotection, the author presents the results he has obtained with natural Iranian product: &apos;'Shir-Khecht'&apos;. Tests with this product at lethal and sublethal doses have been carried out on the rat using various means of introduction. The effect of radiation, both with and without protection, has been studied using histological and biochemical methods. The product examined has, in effect, a protective action; it is, furthermore, non-toxic and active when taken orally. (author) [French] Apres avoir rappele les mecanismes primaires de l&apos;action des rayonnements ionisants, les mecanismes possibles de l&apos;action des substances radioprotectrices, les diverses structures chimiques possedant un effet protecteur et les methodes d&apos;etude de la radioprotection chimique, l&apos;auteur presente les resultats qu&apos;il a obtenus en utilisant un compose naturel iranien: le &apos;'Shir-Khecht'&apos;. Des essais de ce produit, chez le rat, par diverses voies d&apos;introduction, a dose letale et subletale ont ete effectues. L&apos;effet des radiations, avec et sans protection, a ete etudie a l&apos;aide de methodes histologiques et biochimiques. Le compose essaye possede un pouvoir protecteur; il est, de plus, non toxique et actif par voie orale. (auteur)

  2. Under-Threes&apos; Mathematical Learning--Teachers&apos; Perspectives

    Science.gov (United States)

    Franzén, Karin

    2014-01-01

    This project highlights preschool teachers&apos; views of toddlers&apos; learning in mathematics. The Swedish national curriculum covers even the youngest children who are 1-3?years old. Interesting questions are thus: what should mathematics be for this age group and how should preschool teachers work with maths to achieve the curriculum…

  3. Development and utilization of a mechanical barrier for large-calibre cavern necks. The &apos;&apos;Spider Plug&apos;&apos;; Entwicklung und Einsatz einer mechanischen Absperrung fuer grosskalibrige Kavernenhaelse. Der &apos;&apos;Spider Plug&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Pfeifer, K.; Maut, D. [UGS GmbH, Mittenwalde (Germany)

    2013-08-01

    An hydraulic separation of a well and the cavern can be necessary for different workover applications, e.g. casing milling or underreaming. The separation is needed to ensure a mud circulation during such operations. In that case a barrier is set after flooding the cavern, which will then be used as a mechanical abutment for the cement bridge. If the diameter of the cavern neck has been enlarged due to e.g. unwanted leaching processes or unstabilized underreaming processes, it might get impossible to set a standard plug with the available technologies into those diameters. Therefore UGS GmbH has developed a mechanical plug, which is set hydraulically. The so called &apos;Spider Plug&apos; is used as basis for a cement bridge and can be removed by drilling after the workover has been done. Depending on the dimension of the setting tool a cavern neck up to 50&apos;&apos; diameter can be plugged by the &apos;Spider Plug&apos;. Up to now a number of successful operations on different locations has shown, that the &apos;Spider Plug&apos; is a practicable and cost-efficient solution for a mechanical abutment of large cavern necks. (orig.)

  4. Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis

    OpenAIRE

    Huang, Zhi H.; Maeda, Nobuyo; Mazzone, Theodore

    2011-01-01

    Expression of apoE in adipocytes has been shown to have an important role in modulating adipocyte triglyceride (TG) metabolism and gene expression that is independent of circulating and extracellular apoE. The impact of adipocyte expression of common human apoE isoforms was evaluated using adipocytes harvested from human apoE2, -3, and -4 knock-in mice. Expression of the apoE2 isoform was associated with an increase in adipocyte apoE gene expression and apoE synthesis. Newly synthesized apoE2...

  5. Comment on &apos;&apos;Teleportation of two-mode squeezed states&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    He Guangqiang; Zhang Jingtao [State Key Lab of Advanced Optical Communication Systems and Networks Department of Electronic Engineering, Shanghai Jiaotong University, Shanghai 200030 (China)

    2011-10-15

    We investigate the teleportation scheme of two-mode squeezed states proposed by Adhikari et al.[S. Adhikari et al., Phys. Rev. A 77, 012337 (2008)]. It uses four-mode entangled states to teleport two-mode squeezed states. The fidelity between the original two-mode squeezed states and teleported ones is calculated. The maximal fidelity value of Adhikari&apos;s protocol is 0.38, which is incompatible with the fidelity definition with the maximal value 1. In our opinion, one reason is that they calculate the fidelity for multimodes Gaussian states using the fidelity formula for single-mode ones. Another reason is that the covariance matrix of output states should be what is obtained after applying the linear unitary Bogoliubov operations (two cascaded Fourier transformations) on the covariance matrix given in Eq. (12) in their paper. These two reasons result in the incomparable results. In addition, Adhikari&apos;s protocol can be simplified to be easily implemented.

  6. Technology &apos;90

    Energy Technology Data Exchange (ETDEWEB)

    1991-01-01

    The US Department of Energy (DOE) laboratories have a long history of excellence in performing research and development in a number of areas, including the basic sciences, applied-energy technology, and weapons-related technology. Although technology transfer has always been an element of DOE and laboratory activities, it has received increasing emphasis in recent years as US industrial competitiveness has eroded and efforts have increased to better utilize the research and development resources the laboratories provide. This document, Technology &apos;90, is the latest in a series that is intended to communicate some of the many opportunities available for US industry and universities to work with the DOE and its laboratories in the vital activity of improving technology transfer to meet national needs. Technology &apos;90 is divided into three sections: Overview, Technologies, and Laboratories. The Overview section describes the activities and accomplishments of the DOE research and development program offices. The Technologies section provides descriptions of new technologies developed at the DOE laboratories. The Laboratories section presents information on the missions, programs, and facilities of each laboratory, along with a name and telephone number of a technology transfer contact for additional information. Separate papers were prepared for appropriate sections of this report.

  7. Finding the object&apos;&apos; proceedings addendum

    Energy Technology Data Exchange (ETDEWEB)

    Whiting, M.A.; Devaney, D.M.

    1990-10-01

    The purpose of this workshop was to discuss finding the object -- that is, how software engineers imagine, invent, design, or recycle objects and their behaviors for object-oriented software engineering. The workshop organizers (and, as we subsequently discovered, several of the workshop participants) felt that this issue is crucial to successful object-oriented software engineering (after all, finding objects is what the projects is all about, isn&apos;t it ). Unfortunately, when previous workshops have had the opportunity to review and discuss techniques practitioners use to find objects, too often the results were heated debates on what is an object &apos;&apos; which becomes all consuming. We believed that, given appropriate control over the question of which kind of object&apos;&apos; is being discussed (which meant tell us what object you are trying to find, then tell us your method), a workshop to concentrate on techniques for finding objects would be quite appropriate. 8 refs., 2 figs.

  8. &apos;Green Isle&apos; on the &apos;Red Isle&apos;. The gasometer in Berlin becomes a centre of the &apos;European Energy Forum&apos;; &apos;Gruene Insel&apos; auf der &apos;Roten Insel&apos;. Der Berliner Gasometer wird zum Zentrum des &apos;Europaeischen Energie Forums&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Ulf

    2013-06-01

    If the ARD political talk show with Guenther Jauch starts on Sunday night after the crime thriller, only few viewers know that they are tele-guests on the former gasometer site in Berlin-Schoeneberg. Currently, this site is being transformed into an environmentally friendly campus called the &apos;European Energy Forum&apos; (EUREF). According to the will of the owner and architect Reinhard Mueller, the campus will become the largest CO{sub 2} neutral office and business location in Europe. Totally 600 million Euro will be invested. All new buildings should be ecological &apos;green buildings&apos; and received the LEED Gold certification.

  9. Ascite pancreática: tratamento com octreotide: relato de caso = Pancreatic ascites: treatment with octreotide: Case report

    Directory of Open Access Journals (Sweden)

    Diogo, Luciano Passamani

    2005-01-01

    Comentários: O tratamento da ascite pancreática é ainda controverso. Divide-se basicamente em conservador e intervencionista, sendo este último subdividido em tratamento endoscópico e cirúrgico. Apesar do sucesso do tratamento com octreotide no caso relatado, e diante de poucas e controversas evidências na literatura, um número maior de pacientes é necessário para determinar o melhor tratamento para ascite pancreática, permanecendo este motivo de debate

  10. Tratamento cirúrgico para aspiração

    Directory of Open Access Journals (Sweden)

    Manrique Dayse

    2001-01-01

    Full Text Available Introdução: Quando o mecanismo protetor da laringe está comprometido, o paciente pode apresentar aspiração traqueal, com graves complicações pulmonares. Objetivo: Relatar 15 casos de tratamento cirúrgico para o controle da aspiração crônica, incluindo as técnicas cirúrgicas empregadas, seus resultados e complicações. Forma de estudo: Avaliação retrospectiva. Material e método: No período de 1997 a 2000, 15 pacientes foram submetidos à cirurgia para controle da aspiração, na AACD - São Paulo/SP. As técnicas cirúrgicas empregadas foram classificadas em: oclusão laríngea supraglótica; oclusão laríngea glótica; oclusão subglótica ou separação laringotraqueal. Foi avaliado o perfil dos pacientes em relação a sexo, idade, etiologia de base, traqueotomia prévia, via preferencial de alimentação, redução das infecções pulmonares, tempo de seguimento pós-operatório e complicações. Resultados: Oito pacientes eram do sexo masculino e sete do feminino, com idade média de nove anos e dois meses. A doença etiológica de base mais comum foi a encefalopatia crônica. Dez pacientes foram submetidos à traqueotomia previamente à cirurgia. Nove pacientes apresentaram, no pós-operatório, dieta via oral de pelo menos 50% do volume requerido. Os 15 pacientes evoluíram com diminuição no número e na gravidade das infecções pulmonares. O tempo de seguimento pós-operatório variou de quatro a 36 meses. Um paciente evoluiu com deiscência parcial na técnica de oclusão laríngea supraglótica. Conclusão: A cirurgia para controle da aspiração traqueal, nas três técnicas utilizadas, foi eficaz para prevenção da aspiração, refletindo na melhora clínica e na qualidade de vida dos pacientes.

  11. CONSTRAINING THE EVOLUTIONARY FATE OF CENTRAL COMPACT OBJECTS: &apos;'OLD'&apos; RADIO PULSARS IN SUPERNOVA REMNANTS

    International Nuclear Information System (INIS)

    Central compact objects (CCOs) constitute a population of radio-quiet, slowly spinning (≥100 ms) young neutron stars with anomalously high thermal X-ray luminosities. Their spin-down properties imply weak dipole magnetic fields (∼1010-11 G) and characteristic ages much greater than the ages of their host supernova remnants (SNRs). However, CCOs may posses strong &apos;'hidden'&apos; internal magnetic fields that may re-emerge on timescales of ≳10 kyr, with the neutron star possibly activating as a radio pulsar in the process. This suggests that the immediate descendants of CCOs may be masquerading as slowly spinning &apos;'old'&apos; radio pulsars. We present an X-ray survey of all ordinary radio pulsars within 6 kpc that are positionally coincident with Galactic SNRs in order to test the possible connection between the supposedly old but possibly very young pulsars and the SNRs. None of the targets exhibit anomalously high thermal X-ray luminosities, suggesting that they are genuine old ordinary pulsars unrelated to the superposed SNRs. This implies that CCOs are either latent radio pulsars that activate long after their SNRs dissipate or they remain permanently radio-quiet. The true descendants of CCOs remain at large

  12. &apos;&apos;Dural tail&apos;&apos; adjacent to acoustic neuroma on MRI: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Lunardi, P. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Mastronardi, L. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Nardacci, B. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Acqui, M. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy)); Fortuna, A. (Dept. of Neurological Sciences-Neurosurgery, Univ. ' ' La Sapienza' ' , Rome (Italy))

    1993-04-01

    A &apos;dural tail&apos; on Gd-DTPA-enhanced MRI has been often observed adjacent to meningiomas and considered to be useful in distinguishing meningioma of the cerebellopontine angle from acoustic neuroma. However, demonstration of a dural tail adjacent to an acoustic neuroma indicates that this sign is not specific. (orig.)

  13. Possibilities for a sustainable development. Muligheter for en baerekraftig utvikling; Analyser paa &apos;&apos;World Model&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Bjerkholt, O.; Johnsen, T.; Thonstad, K.

    1993-01-01

    This report is the final report of a project that the Central Bureau of Statistics of Norway has carried out. The report present analyses of the relations between economic development, energy consumption and emission of pollutants to air in a global perspective. The analyses are based on the &apos;&apos;World Model&apos;&apos;, that has been developed at the Institute for Economic Analysis at New York University. The analyses show that it will be very difficult to obtain a global stabilization of the CO[sub 2] emission on the 1990 level. In the reference scenario of the United Nations report &apos;&apos;Our Common Future&apos;&apos;, the increase of CO[sub 2] emissions from 1990 to 2020 was 73%. Even in the scenario with the most drastic measures, the emissions in 2020 will be about 43% above the 1990 level, according to the present report. A stabilization of the global emissions at the 1990 level will require strong measures beyond those assumed in the model calculations, or a considerable breakthrough in energy technology. 17 refs., 5 figs., 21 tabs.

  14. Cerebral Hemorrhage and APOE genotype

    Institute of Scientific and Technical Information of China (English)

    Sun xiaojiang; Wu ping; Zhang jing; Lu shanqing; Li bing

    2000-01-01

    Background and Purpose: Current evidence Suggests that the apolipoprotein E (APOE)ε 4 allele predisposes to cerebral amyloid angiopathy (CAA) whereas ε 2 is associated with CAA-zelated hemorrhage. In this study we examined potential clinical risk factors inpatients with cerebral hemorrhage and assessed these with respect to APOE genotype. Methoeds: 146 patinas with cerebral hemorrhage and 70 normal controls were investigated. APOE genotypes were determined with use of polymerase Chain reaction techniques.Results: The frequency of allele gene ( 0.180 ) and the percentage of the APOE ε 4 genotype in the cerebral hemorrhage group were Significantly higher as compared with the e 4 prequency ( O.O72 ) in the control group respectively ( p=O.O389 ) .Conelusious: APOE ε 4 :allele is a risk gene for cerebral hemorrhage.

  15. Results of the Danish &apos;&apos;high efficiency motors campaign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Malmose, K.

    2000-07-01

    In Denmark energy consultancy (demand side management activities (DSM)) took its first steps in the middle of the 80&apos;ies. The energy consultancy was built up around the Danish electric utilities on which the Danish government imposed the implementation of energy savings for funds collected through the electricity bill (approx. 0.0006 DKK/kWh corresponding to approx. 0.001 ECU). The electric utilities trained energy consultants who specialised in visiting industrial enterprises and counselling on energy consumption, primarily focusing on auxiliary systems like lighting, compressed air, ventilation and heating. Within these areas large savings could be obtained because each company was focusing on the actual production but also because the cost of energy was a fraction of the total costs. (orig.)

  16. Stratospheric sulfate from the Gareloi eruption, 1980: Contribution to the &apos;'ambient'&apos; aerosol by a poorly documented volcanic eruption

    Energy Technology Data Exchange (ETDEWEB)

    Sedlacek, W.A.; Mroz, E.J.; Heiken, G.

    1981-07-01

    While sampling stratospheric aerosols during July--August 1980 a plume of &apos;'fresh'&apos; volcanic debris was observed in the Northern hemisphere. The origin of this material seems to be a poorly documented explosive eruption of Gareloi valcano in the Aleutian Islands. The debris was sampled at an altitude of 19.2 km: almost twice the height of observed eruption clouds. Such remote, unobserved or poorly documented eruptions may be a source that helps maintain the &apos;'ambient'&apos; stratospheric aerosol background.

  17. Vertiefungskurs 2014. Safety margins in nuclear power plants. Identify, quantify and extend; Vertiefungskurs 2014 zum Thema &apos;&apos;Sicherheitsmargen in Kernkraftwerken. Identifizieren, quantifizieren, erweitern&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Rey, Matthias

    2015-02-15

    Fifteen speakers dealt with the topic safety margins in nuclear power plants from different points of view at the &apos;&apos;Vertiefungskurs 2014&apos;&apos; of the Nuklearforum Schweiz in Olten, 4 and 5 November 2014. In the context of the &apos;&apos;Vertiefungskurs 2014&apos;&apos; the safety margins in power plants were considered and quantified and possible extensions have been discussed. The conference started with an in-depth introduction of the basis design of existing nuclear power plants. Thereafter speakers told about the main topics emergency preparedness, knowledge management and safety retrofit of nuclear power plants in operation.

  18. Produção de matrizes à base de quitosano para o tratamento de feridas

    OpenAIRE

    Machado, Ana Espiga

    2014-01-01

    A pele é o maior órgão do corpo humano cuja função é comprometida pela ocorrência de feridas. O tratamento de feridas representa uma fracção considerável dos gastos em saúde, sendo o desenvolvimento de novos métodos de tratamento alvo de grande interesse. Uma das vertentes desta investigação é a utilização de novas matérias-primas na produção de dispositivos médicos(DM) para o tratamento de feridas. O quitosano é um derivado da quitina, o segundo biopolímero mais abundante. As propriedades...

  19. Tratamento do paciente com mielodisplasia de alto risco Treatment of myelodysplastic syndrome in high risk patients

    OpenAIRE

    Evandro M. Fagundes

    2006-01-01

    O tratamento do paciente com mielodisplasia deve ser feito considerando o risco biológico da doença, a idade e as condições clínicas do paciente. De um modo geral, uma doença de alto risco necessitaria de um tratamento mais agressivo. Porém, devido à elevada idade mediana no diagnóstico, a maioria dos pacientes não tolera tratamentos intensivos. O transplante de células-tronco hematopoiéticas é a única opção para aqueles que objetivam a cura da doença. Para aqueles que não podem se submeter a...

  20. Tratamento farmacológico do tabagismo Pharmacological treatment of tobacco dependence

    Directory of Open Access Journals (Sweden)

    Guilherme Rubino de A. Focchi

    2005-10-01

    Full Text Available A cada ano, o tabagismo mata 5 milhões de pessoas em todo o mundo; este número tende a crescer nos próximos anos. A farmacoterapia tem grande importância no tratamento da dependência de nicotina. Este artigo faz uma revisão crítica dos principais tratamentos medicamentosos usados atualmente para o tratamento deste transtorno: a terapia de reposição de nicotina, a bupropiona e a nortriptilina.Each year, nicotine dependence kills five million people around the world and the morbidity and mortality due to tobacco use tends to increase in the following years. Pharmacotherapy has great importance in the treatment of nicotine dependence. This paper presents a critical review of the main pharmacotherapies presently available for the treatment of this disorder: nicotine replacement, bupropion and nortriptyline.

  1. EUGRIS: &apos;&apos;European Substainable Land and Groundwater Management Information System&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Frauenstein, J. [Federal Environmental Agency (UBA), Berlin (Germany)

    2003-07-01

    The presentation outlines and Accompanying Measure with the FP 5 to develop an web based EUropean Sustainable Land and GRoundwater Management Information System information system (EUGRIS). The management of contaminated land and groundwater requires an interdisciplinary approach and a considerable amount of supporting technical information and knowledge. EUGRIS will provide a generally available comprehensive and overarching information and innovation resource, to support both research and practical contaminated land and groundwater management. EUGRI is a gateway to provide a &apos;one stop shop&apos; for information provided by research projects, legislation, standards, best practice and other technical guidance and policy/regulatory publications from the EC, participating Member and Accession States and from various international networks dealing with groundwater and land management issues. Different types of user can access information through different windows according to their needs. EUGRIS will provide its visitors with summary information (digests) and links to sources of more detailed and/or original information in a scaleable holistic and contexturally meaningful way. EUGRIS is being built in three stages: the design of the information system, the development of its software implementation, and the population of the system with information. The presentation is focussed on the concept of the development of the information system with the individual work packages. In the second part of the lecture in particular the work procedures are presented for the content wise replenishment by EUGRIS. The data collation for the proven pilot countries and the production of a European research data base, which opens contents and results of European-wide locked and current projects, form the emphasis thereby. (orig.)

  2. &apos;Action 2016&apos;: AREVA&apos;s strategic action plan to improve performance; &apos;Action 2016&apos;: le plan d&apos;actions strategique d&apos;AREVA pour ameliorer sa performance

    Energy Technology Data Exchange (ETDEWEB)

    Marie, Patricia; Floquet-Daubigeon, Fleur; Michaut, Maxime; De Scorbiac, Marie; Du Repaire, Philippine

    2011-12-12

    On December 12, 2011, Luc Oursel, Executive Officer of AREVA, and Pierre Aubouin, Chief Financial Executive Officer, presented the group&apos;s &apos;Action 2016&apos; strategic action plan based on an in-depth analysis of the market&apos;s outlook. This document makes, first, a Detailed presentation of the &apos;Action 2016&apos; plan and then presents the group&apos;s financial outlook: - Full-year 2011 immediate accounting consequences of the new market environment: operating losses expected in 2011; - 2012-2013 transition period Objective: self-finance capex in cumulative terms; - 2014-2016: safe growth and cash generation, free operating cash flow at break-even beginning in 2013, above euro 1 bn per year beginning in 2015

  3. Custo-utilidade do tratamento do glaucoma primário de ângulo aberto no Brasil

    Directory of Open Access Journals (Sweden)

    Ricardo Augusto Paletta Guedes

    2016-02-01

    Full Text Available RESUMO Objetivo: Determinar a estratégia mais custo-efetiva para o tratamento do glaucoma primário de ângulo aberto em fase inicial, comparando-se as seguintes alternativas: observação, tratamento clínico ou tratamento com laser. Métodos: Por meio de um modelo de Markov, sob a perspectiva do Sistema Único de Saúde (SUS e um horizonte da expectativa de vida média da população brasileira. Comparou-se a razão de custo-utilidade incremental (ICUR entre 3 alternativas de tratamento, assim como seus custos e o ganho em qualidade de vida, medido em QALY (Quality-adjusted life years. Resultados: A ICUR do tratamento inicial com laser e do tratamento inicial com colírios, em relação a não tratar foi de R$ 2.811,39/QALY e R$ 3.450,47/QALY, respectivamente. Ambas as estratégias foram custo-efetivas, com uma discreta vantagem para o tratamento a laser. Esta diferença diminui ainda mais quando se aumenta a idade de entrada no modelo. As duas alternativas propiciaram ganhos significativos de qualidade de vida (em torno de 2,5 QALYs para o tratamento com laser e de 5,0 QALYs para o tratamento com colírios. Conclusão: Tanto o tratamento primário com trabeculoplastia a laser quanto com medicações foram custo-efetivos e proporcionaram ganhos reais de qualidade de vida quando comparados com o não tratamento do GPAA.

  4. Rosuvastatina e ciprofibrato no tratamento da dislipidemia em pacientes com HIV

    Directory of Open Access Journals (Sweden)

    Hamilton Domingos

    2012-11-01

    Full Text Available FUNDAMENTO: A dislipidemia secundária à terapia antirretroviral potente nos pacientes com HIV está associada à significativa elevação da morbimortalidade cardiovascular por doença aterosclerótica, sendo, portanto, necessário tratamento imediato e eficaz. OBJETIVO: Demonstrar a efetividade e a segurança da rosuvastatina e do ciprofibrato no tratamento da dislipidemia associada à terapia antirretroviral potente em pacientes com HIV. MÉTODOS: Trezentos e quarenta e seis pacientes com dislipidemia foram submetidos a tratamento farmacológico: 200 pacientes com hipertrigliceridemia receberam ciprofibrato (Grupo I; 79 pacientes com hipercolesterolemia receberam rosuvastatina (Grupo II; e 67 pacientes com dislipidemia mista receberam ciprofibrato associado a rosuvastatina (Grupo III. O perfil lipídico foi avaliado antes e após o tratamento hipolipemiante, sendo feita comparação estatística pelo teste de Wilcoxon. Transaminases hepáticas e creatinofosfoquinase foram dosadas para controle de toxicidade hepática e muscular. RESULTADOS: As concentrações séricas de triglicérides e de colesterol total foram significativamente menores do que as obtidas antes do tratamento, para os três grupos experimentais (p < 0,002. Observou-se aumento significativo do HDL colesterol nos grupos experimentais I e III (p < 0,002. Nos grupos I e II, o LDL-colesterol foi significativamente menor (p < 0,001. Nenhum dos pacientes apresentou elevações de transaminases ou de creatinofosfoquinase a níveis de toxicidade significativa. CONCLUSÃO: Os resultados deste estudo demonstram que ciprofibrato, rosuvastatina ou a combinação de ambos pode ser considerada tratamento hipolipemiante efetivo, seguro e com boa tolerância nos pacientes com Aids submetidos à terapia antirretroviral potente.

  5. Ronco: critérios diagnósticos e tratamento Snoring: diagnostic criteria and treatment

    Directory of Open Access Journals (Sweden)

    Flávio José Magalhães da Silveira

    2010-06-01

    Full Text Available O ronco é um problema importante com consequentes manifestações sociais e médicas. O passo inicial consiste em confirmar a presença do ronco e excluir qualquer doença respiratória noturna para que o tratamento adequado seja instituído. Este capítulo analisa o gerenciamento atual do ronco e seu tratamento.Snoring is a significant problem with social and medical manifestations. After snoring has been confirmed, other nocturnal respiratory diseases should be excluded so that the appropriate treatment can be instituted. This chapter addresses the current management of snoring and its treatment.

  6. Cistos de bolsa de Rathke: diagnóstico e tratamento

    Directory of Open Access Journals (Sweden)

    Rodrigues Flávio Freinkel

    2001-01-01

    Full Text Available Estudamos retrospectivamente quatro pacientes com cisto de bolsa de Rathke. Chamamos a atenção para a apresentação clínica e para o tratamento destas lesões. Todos ocorreram em pacientes do sexo feminino. Os sintomas predominantes foram amenorréia, cefaléia e déficit visual. Revisamos várias séries publicadas de cistos de bolsa de Rathke. Concluimos que o tratamento cirúrgico é ainda a melhor conduta e que a via transesfenoidal é a abordagem mais indicada.

  7. Tratamento farmacológico de transtornos alimentares Pharmacological treatment of eating disorders

    Directory of Open Access Journals (Sweden)

    Fábio Tapia Salzano

    2004-01-01

    Full Text Available Os autores revisaram a literatura a respeito do tratamento farmacológico para transtornos alimentares, incluindo anorexia nervosa, bulimia nervosa e transtorno da compulsão alimentar periódica. São apresentadas evidências clínicas relacionadas ao uso de psicofármacos nos transtornos alimentares e apontadas, ainda, as perspectivas futuras para o tratamento.The authors have revised the literature about the pharmacological treatment of eating disorders, including anorexia nervosa, bulimia nervosa and binge-eating disorder. Clinical evidences of the medications action in eating disorders are presented, and future perspectives for the treatment are indicated.

  8. Fatores influentes na aderência ao tratamento em pacientes com risco cardiovascular

    OpenAIRE

    Rodríguez Acelas, Alba Luz; GÓMEZ OCHOA, ANA MARITZA

    2010-01-01

    Objetivo: descrever e analisar os fatores que influem na aderência ao tratamento farmacológico e não farmacológico em pacientes com risco de doença cardiovascular na Fundação Cardiovascular da Colômbia. Metodologia: estudo descritivo – metodológico realizado com 172 pacientes hospitalizados e de consulta ambulatória. O instrumento aplicado foi desenhado por Bonilla (8) e é útil para avaliar a aderência aos tratamentos farmacológicos e não farmacológicos em pacientes com fatores de risco de...

  9. O uso da terapia cognitivo-comportamental no tratamento do transtorno depressivo: uma abordagem em grupo

    Directory of Open Access Journals (Sweden)

    Terezinha Rech

    2010-01-01

    Full Text Available A depressão tem atingido amplos grupos sociais sem distinção entre eles e, constantemente, está associada como comorbidade a outras doenças. A Terapia Cognitivo- Comportamental (TCC começou a ser estruturada pelo psicanalista e psiquiatra Aaron Beck para oferecer tratamento a pessoas deprimidas. Foi aprimorada e chegou a propostas de tratamento em grupo desenvolvidas por Aaron Beck e demais colaboradores. Este estudo procura fazer uma breve revisão dos temas da TCC e de sua aplicação no tratamento em grupo para depressão, desde a sua formulação até a revisão do uso dessa terapia na atualidade. Foram analisados artigos do ano de 2008 dessa metodologia de trabalho e comparados com os cânones dessa tipologia de tratamento. A depressão tem atingido amplos grupos sociais sem distinção entre eles e, constantemente, está associada como comorbidade a outras doenças. A Terapia Cognitivo- Comportamental (TCC começou a ser estruturada pelo psicanalista e psiquiatra Aaron Beck para oferecer tratamento a pessoas deprimidas. Foi aprimorada e chegou a propostas de tratamento em grupo desenvolvidas por Aaron Beck e demais colaboradores. Este estudo procura fazer uma breve revisão dos temas da TCC e de sua aplicação no tratamento em grupo para depressão, desde a sua formulação até a revisão do uso dessa terapia na atualidade. Foram analisados artigos do ano de 2008 dessa metodologia de trabalho e comparados com os cânones dessa tipologia de tratamento. Abstract Depression affects a variety of social groups without distinction, and usually occurs as comorbidity with other disorders. The Cognitive Behavioral Therapy (CBT was originally structured by Aaron Beck to provide treatment to depressed people. It was later improved by him and his collaborators and developed into a proposal of group therapy. This study comprises a brief review of CBT topics and their application in group therapy of depression, from its formulation to its

  10. Hipertensão pulmonar persistente neonatal: recentes avanços na fisiopatologia e tratamento

    OpenAIRE

    Joaquim E.B. Cabral; Jaques Belik

    2013-01-01

    OBJETIVOS: Embora reconhecida há décadas, ainda pouco se sabe a respeito da etiologia, fisiopatologia e prevenção da hipertensão pulmonar persistente neonatal (HPPN), e seu tratamento continua a ser um grande desafio para os neonatologistas. Nesta revisão, vamos abordar as características clínicas e os mecanismos fisiopatológicos da síndrome, assim como seu tratamento geral e específico. FONTES DE DADOS: Fizemos uma revisão nas bases de dados PubMed, Cochrane Library e MRei Consult , procuran...

  11. Tratamento farmacológico dos transtornos alimentares Pharmacological treatment of eating disorders

    OpenAIRE

    Jose C Appolinario; Josue Bacaltchuk

    2002-01-01

    O tratamento dos transtornos alimentares (TA) geralmente exige uma abordagem multidisciplinar em que a farmacoterapia é adjuvante de abordagens psicológicas e nutricionais. Psicotrópicos são indicados para a maioria dos pacientes com TA para tratar as comorbidades e também os sintomas chamados nucleares. Progressos importantes estão ocorrendo nos últimos anos. Este artigo apresenta uma revisão das evidências atuais e perspectivas futuras para o tratamento farmacológico da anorexia nervosa, bu...

  12. The development and treatment of impulsivity = O desenvolvimento e tratamento da impulsividade

    OpenAIRE

    Amorim Neto, Roque do Carmo; True, Mary

    2011-01-01

    Impulsividade é um fator presente em várias desordens psicológicas, incluindo ADHD, drogadição, comportamentos agressivos e automutiladores, e obesidade infantil. Impulsividade também é um fator de risco para o abandono de tratamento. Este artigo tem por objetivo apresentar as raízes da impulsividade do ponto de vista biológico, sociológico e do desenvolvimento humano, bem como as formas de tratamento mais comuns para pessoas com extrema impulsividade. Aqui também se inclui pesquisas das área...

  13. Biossegurança na perspectiva da equipe de enfermagem de Unidades de Tratamento Intensivo

    OpenAIRE

    Cátia Inácia Brand; Rosane Teresinha Fontana

    2014-01-01

    Trata-se de um estudo descritivo, com abordagem qualitativa, que teve como objetivo investigar saberes e práticas da equipe de enfermagem sobre biossegurança em Unidades de Tratamento Intensivo, bem como identificar situações de risco biológico a que o trabalhador está exposto e a adesão das unidades à Norma Regulamentadora nº 32. A coleta de dados foi feita por meio de entrevista e observação, no primeiro semestre de 2012, e o tratamento dos dados deu-se mediante análise temática. O estudo p...

  14. Acidentes com Hipoclorito de Sódio durante o Tratamento Endodôntico

    OpenAIRE

    Serrão, Nadine Raquel Pereira Martins

    2014-01-01

    A endodontia tem vindo a evoluir substancialmente nas últimas décadas. O desenvolvimento de novas tecnologias e materiais, facilitam o trabalho do médico dentista e diminuem o tempo do tratamento endodôntico. Contudo, os insucessos estão relacionados diretamente com a persistência de microrganismos que resistem ao preparo químico-mecânico. A irrigação durante o tratamento endodôntico é, portanto, fundamental para que se consiga obter uma limpeza adequada do sistema de canais...

  15. Tratamento de parasitoses intestinais pela associação piperazina-tiabendazol

    Directory of Open Access Journals (Sweden)

    Adelina S. Velho Soli

    1972-08-01

    Full Text Available Os autores apresentam os resultados obtidos com o emprego da associação antihelmintica piperazina-tiabendazol no tratamento de infecção por Ascaris lumbricoides e ancilostomídeos. Considerando a cura de 81 % dos casos de ascaridíase e de 80% dos casos de ancilostomíase, bem como a ótima tolerância ao medicamento, acreditam que esta associação medicamentosa possa ser empregada com sucesso para o tratamento das referidas parasitoses.

  16. The development and treatment of impulsivity = O desenvolvimento e tratamento da impulsividade

    Directory of Open Access Journals (Sweden)

    Amorim Neto, Roque do Carmo

    2011-01-01

    Full Text Available Impulsividade é um fator presente em várias desordens psicológicas, incluindo ADHD, drogadição, comportamentos agressivos e automutiladores, e obesidade infantil. Impulsividade também é um fator de risco para o abandono de tratamento. Este artigo tem por objetivo apresentar as raízes da impulsividade do ponto de vista biológico, sociológico e do desenvolvimento humano, bem como as formas de tratamento mais comuns para pessoas com extrema impulsividade. Aqui também se inclui pesquisas das áreas de desenvolvimento neuronal e regulação emocional

  17. Estimation of doses to patients from &apos;'complex'&apos; conventional X-ray examinations

    Energy Technology Data Exchange (ETDEWEB)

    Calzado, A.; Vano, E.; Moran, P.; Ruiz, S.; Gonzalez, L. (Universidad Complutense de Madrid (Spain). Catedra de Fisica Medica); Castellote, C. (Hospital Militar Central ' ' Gomez Ulla' ' , Madrid (Spain). Dept. de Radiologia)

    1991-06-01

    A numerical method has been developed to estimate organ doses and effective dose-equivalent for patients undergoing three &apos;complex&apos; examinations (barium meal, barium enema and intravenous urography). The separation of radiological procedures into a set of standard numerical views is based on the use of Monte Carlo conversion factors and measurements within a Remab phantom. Radiation doses measured in a phantom for such examinations were compared with predictions of the &apos;'numerical'&apos; method. Dosimetric measurements with thermoluminescent dosemeters attached to the patient&apos;s skin along with measurements of the dose-area product during the examination have enabled the derivation of organ doses and to estimate effective dose-equivalent. Mean frequency weighted values of dose-area product, energy imparted to the patient, doses to a set of organs and effective dose-equivalent in the area of Madrid are reported. Comparisons of results with those from similar surveys in other countries were made. (author).

  18. Documentation to the workshop &apos;Cluster in the environmental protection economy&apos;; Dokumentation zum Workshop &apos;&apos;Cluster in der Umweltschutzwirtschaft&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-12-11

    Within the workshop &apos;Cluster in the environmental protection economy&apos; at the Umweltbundesamt (Dessau-Rosslau, Federal Republic of Germany) at 27th November, 2008, the following lectures were held: (a) Which contribution can cluster and cluster politics contribute to the promotion of the environmental protection economy? (Harald Legler); (b) Cluster in the environmental protection economy: Targets and expectations (Dieter Rehfeld); (c) Demands at the management of clusters (Karin Hoerhan); (d) Demands at the cluster politics in the environmental protection economy (Bernhard Hausberg); (e) Photovoltaics in Eastern Germany (Johann Wackenbauer); (f) Automotive industry in Bergisches Land (Thomas Lemken); (g) Competence centre environment Augsburg-Schwaben (Egon Beckord).

  19. ApoE4 induces synaptic and ERG impairments in the retina of young targeted replacement apoE4 mice.

    Directory of Open Access Journals (Sweden)

    Ran Antes

    Full Text Available The vertebrate retina, which is part of the central nervous system, is a window into the brain. The present study investigated the extent to which the retina can be used as a model for studying the pathological effects of apolipoprotein E4 (apoE4, the most prevalent genetic risk factor for Alzheimer's disease (AD. Immunohistochemical studies of retinas from young (4 months old apoE4-targeted replacement mice and from corresponding mice which express the AD benign apoE3 allele, revealed that the density of the perikarya of the different classes of retinal neurons was not affected by apoE4. In contrast, the synaptic density of the retinal synaptic layers, which was assessed immunohistochemically and by immunoblot experiments, was significantly lower in the apoE4 than in the apoE3 mice. This was associated with reduced levels of the presynaptic vesicular glutamatergic transporter, VGluT1, but not of either the GABAergic vesicular transporter, VGaT, or the cholinergic vesicular transporter, VAChT, suggesting that the glutamatergic nerve terminals are preferentially affected by apoE4. In contrast, the post synaptic scaffold proteins PSD-95 and Gephyrin, which reside in excitatory and inhibitory synapses, respectively, were both elevated, and their ratio was not affected by apoE4. Electroretinogram (ERG recordings revealed significant attenuation of mixed rod-cone responses in dark-adapted eyes of apoE4 mice. These findings suggest that the reduced ERG response in the apoE4 mice may be related to the observed decrease in the retinal nerve terminals and that the retina could be used as a novel model for non-invasive monitoring of the effects of apoE4 on the CNS.

  20. Magnetooptical measurements of {beta}&apos;&apos;-(BEDT-TTF)(TCNQ)

    Energy Technology Data Exchange (ETDEWEB)

    Kimata, M.; Oshima, Y.; Ohta, H.; Koyama, K.; Motokawa, M.; Yamamoto, H.M.; Kato, R

    2004-04-30

    Magnetooptical measurements have been performed on {beta}&apos;&apos;-(BEDT-TTF)(TCNQ) using the cavity perturbation techniques. {beta}&apos;&apos;-(BEDT-TTF)(TCNQ) has very exotic Fermi surface (FS). Several harmonic resonances were observed at various angles. We consider these resonances as q1D-periodic orbit resonance. The obtained Fermi velocity and the scattering time are 4.4x10{sup 4} m/s and 2.1x10{sup -11} s, respectively. When the magnetic field was rotated in the b{sup *}a-plane, the similar resonances are observed. According to these results, the FS topology of the system at low temperature is discussed.

  1. SOLAR MAGNETIZED &apos;TORNADOES&apos;: RELATION TO FILAMENTS

    Energy Technology Data Exchange (ETDEWEB)

    Su Yang; Veronig, Astrid; Temmer, Manuela [IGAM-Kanzelhoehe Observatory, Institute of Physics, University of Graz, Universitaetsplatz 5, A-8010 Graz (Austria); Wang Tongjiang [Department of Physics, Catholic University of America, Washington, DC 20064 (United States); Gan Weiqun, E-mail: yang.su@uni-graz.at [Key Laboratory of Dark Matter and Space Astronomy, Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008 (China)

    2012-09-10

    Solar magnetized &apos;tornadoes&apos;, a phenomenon discovered in the solar atmosphere, appear as tornado-like structures in the corona but are rooted in the photosphere. Like other solar phenomena, solar tornadoes are a feature of magnetized plasma and therefore differ distinctly from terrestrial tornadoes. Here we report the first analysis of solar &apos;tornadoes&apos; (two papers which focused on different aspects of solar tornadoes were published in the Astrophysical Journal Letters and Nature, respectively, during the revision of this Letter). A detailed case study of two events indicates that they are rotating vertical magnetic structures probably driven by underlying vortex flows in the photosphere. They usually exist as a group and are related to filaments/prominences, another important solar phenomenon whose formation and eruption are still mysteries. Solar tornadoes may play a distinct role in the supply of mass and twists to filaments. These findings could lead to a new explanation of filament formation and eruption.

  2. Characterisation of epeiric &apos;'layer-cake'&apos; carbonate reservoirs: Upper Muschelkalk (Middle Triassic), the Netherlands

    Energy Technology Data Exchange (ETDEWEB)

    Borkhataria, R.; Aigner, T.; Poeppelreiter, M.C.; Pipping, J.C.P. [Shell International Exploration and Production Inc., Houston, TX (United States)

    2005-04-01

    Upper Muschelkalk (Middle Triassic) carbonates produce natural gas at Coevorden field in the NE Netherlands. This is currently the only field that produces gas from this succession although several other prospects have been identified nearby. In order to help develop these hydrocarbons, this study proposes a facies and reservoir model of the Upper Muschelkalk in the NE Netherlands together with a regional framework intended to assist in further evaluation. Distribution of facies and reservoir properties of the Upper Muschelkalk carbonates in the NE Netherlands indicate deposition on a storm-dominated epeiric ramp with a very low gradient. The predominantly muddy and marly lithofacies types in proximal and distal parts of the ramp gradually interfinger with a shoreline-detached &apos;'shoal'&apos;-like ooidal grainstone complex. The best reservoir quality (permeability up to 60 mD) is recognised within dolomitised peloid ooid grainstones. These are interpreted as high-energy backshoal deposits. Reservoir quality decreases in the limestone-dominated &apos;'shoal'&apos; facies and the muddier foreshoal facies. A four-fold hierarchy of depositional cycles describes the systematic and thus predictable vertical variation in reservoir quality (permeability) and quantity (net-to-gross). High-resolution correlation suggests that medium-scale cycles (5 to 15 metres thick) can be traced for hundreds of kilometres. Small-scale cycles (1 to 3 metres thick) are persistent for several tens of kilometres and have sheet-like geometries. Individual reservoir units (several decimetres thick) appear to be laterally continuous over a maximum of a few kilometres although internal flow barriers might be expected. Mapping of Upper Muschelkalk thickness and facies has clearly defined backshoal, &apos;'shoal'&apos; and foreshoal facies belts with distinctly different reservoir characteristics. Typically, reservoir quality and quantity decrease with increasing

  3. Swiss &apos;Electricity&apos; Research Programme 2004-2007; Konzept des Forschungsprogramms &apos;Elektrizitaet&apos; 2004 - 2007

    Energy Technology Data Exchange (ETDEWEB)

    Brueniger, R.

    2004-07-01

    This report issued by the Swiss Federal Office of Energy (SFOE) provides details on Swiss research in the electricity area that is foreseen for the period 2004-2007. The report discusses the current state of electricity research and the strategic goals for the period and presents the organisations involved and their previous work. The general main areas of interest addressed by the programme are noted, such as the storage and transport of electricity as well as its use in communication technologies, motors, domestic appliances and industrial applications. Figures are presented on the programme&apos;s finances and the concept of &apos;trend-watching&apos; groups is briefly addressed.

  4. Folate targeted polymeric &apos;green&apos; nanotherapy for cancer

    Energy Technology Data Exchange (ETDEWEB)

    Narayanan, Sreeja; Binulal, N S; Mony, Ullas; Manzoor, Koyakutty; Nair, Shantikumar; Menon, Deepthy, E-mail: deepthymenon@aims.amrita.edu [Amrita Center for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi-682 041, Kerala (India)

    2010-07-16

    The concept of &apos;green&apos; chemotherapy by employing targeted nanoparticle mediated delivery to enhance the efficacy of phytomedicines is reported. Poly (lactide-co-glycolide) (PLGA) nanoparticles encapsulating a well known nutraceutical namely, grape seed extract (GSE)-&apos;NanoGSE&apos;-was prepared by a nanoprecipitation technique. The drug-loaded nanoparticles of size {approx} 100 nm exhibited high colloidal stability at physiological pH. Molecular receptor targeting of this nanophytomedicine against folate receptor over-expressing cancers was demonstrated in vitro by conjugation with a potential cancer targeting ligand, folic acid (FA). Fluorescence microscopy and flow cytometry data showed highly specific cellular uptake of FA conjugated NanoGSE on folate receptor positive cancer cells. Studies were also conducted to investigate the efficiency of targeted (FA conjugated) versus non-targeted (non-FA conjugated) nanoformulations in causing cancer cell death. The IC{sub 50} values were lowered by a factor of {approx} 3 for FA-NanoGSE compared to the free drug, indicating substantially enhanced bioavailability to the tumor cells, sparing the normal ones. Receptor targeting of FA-NanoGSE resulted in a significant increase in apoptotic index, which was also quantified by flow cytometry and fluorescence microscopy. This in vitro study provides a basis for the use of nanoparticle mediated delivery of anticancer nutraceuticals to enhance bioavailability and effectively target cancer by a &apos;green&apos; approach.

  5. Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment.

    Science.gov (United States)

    Salomon-Zimri, Shiran; Glat, Micaela Johanna; Barhum, Yael; Luz, Ishai; Boehm-Cagan, Anat; Liraz, Ori; Ben-Zur, Tali; Offen, Daniel; Michaelson, Daniel M

    2016-06-30

    Apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with increased neurodegeneration and vascular impairments. Vascular endothelial growth factor (VEGF), originally described as a key angiogenic factor, has recently been shown to play a crucial role in the nervous system. The objective of this research is to examine the role of VEGF in mediating the apoE4-driven pathologies. We show that hippocampal VEGF levels are lower in apoE4 targeted replacement mice compared to the corresponding apoE3 mice. This effect was accompanied by a specific decrease in both VEGF receptor-2 and HIF1-α. We next set to examine whether upregulation of VEGF can reverse apoE4-driven pathologies, namely the accumulation of hyperphosphorylated tau (AT8) and Aβ42, and reduced levels of the pre-synaptic marker, VGluT1, and of the ApoE receptor, ApoER2. This was first performed utilizing intra-hippocampal injection of VEGF-expressing-lentivirus (LV-VEGF). This revealed that LV-VEGF treatment reversed the apoE4-driven cognitive deficits and synaptic pathologies. The levels of Aβ42 and AT8, however, were increased in apoE3 mice, masking any potential effects of this treatment on the apoE4 mice. Follow-up experiments utilizing VEGF-expressing adeno-associated-virus (AAV-VEGF), which expresses VEGF specifically under the GFAP astrocytic promoter, prevented this effects on apoE3 mice, and reversed the apoE4-related increase in Aβ42 and AT8. Taken together, these results suggest that apoE4-driven pathologies are mediated by a VEGF-dependent pathway, resulting in cognitive impairments and brain pathology. These animal model findings suggest that the VEGF system is a promising target for the treatment of apoE4 carriers in AD.

  6. Deep-sea drilling. Practical aspects of 4D seismic: what an engineer needs to know. Developments in Iran: &apos;SIRRI&apos; of the Total company and &apos;DOROOD&apos; of the Elf company. The &apos;DOROOD&apos; operating plan. The &apos;SIRRI&apos; operating plan; Le forage en eau profonde. Aspects pratiques de la sismique 4D: ce qu&apos;un ingenieur doit savoir. Developpements en Iran: &apos;SIRRI&apos; de Total et &apos;DOROOD&apos; d&apos;Elf. Le projet &apos;DOROOD&apos;. Le projet &apos;SIRRI&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Claverie, P. [Schlumberger Sedco Forex, 92 - Montrouge (France); Bauquis, P.R. [Association Francaise des Techniciens et Professionnels du Petrole, AFTP, 92 - Paris-la-Defense (France); Seiller, B.; Geronimi, X. [Elf France, (France); Barthe, D. [Total Fina, 92 - La Defense (France)

    1999-08-01

    In this &apos;Drilling-Production&apos; section, in which 7 papers are gathered, 3 main topics are developed: (1)the deep-sea drilling (2)the practical aspects of 4D seismic (3)the &apos;SIRRI&apos; and &apos;DOROOD&apos; operating plans in Iran. Concerning the first point, it can be noticed that nowadays, mobile platforms are located in great offshore where water depths are of about 2400 m. In the second point is particularly detailed what 4D is, what it can do, what the primary conditions for it works are and how it costs. The third point is the more particularly detailed in this section (15 pages). At first an introduction indicates why Iran has to call to international petroleum investors, what the current problems of Iran are, what Iran has to do to attract foreign investment and technology and what the challenges to foreign companies are. Then the two operating plans: &apos;SIRRI&apos; and &apos;DOROOD&apos; are exposed into details. A synthesis of these plans, called of &apos;Buy Back&apos;, (production, investment, refund) is given as well as their advantages and disadvantages. (O.M.)

  7. Calculation of LDL apoB

    NARCIS (Netherlands)

    Sniderman, A.D.; Tremblay, A.J.; Graaf, J. de; Couture, P.

    2014-01-01

    OBJECTIVES: This study tests the validity of the Hattori formula to calculate LDL apoB based on plasma lipids and total apoB. METHODS: In 2178 patients in a tertiary care lipid clinic, LDL apoB calculated as suggested by Hattori et al. was compared to directly measured LDL apoB isolated by ultracent

  8. &apos;&apos;{sup local}Renewables model communities network&apos;&apos;. An international initiative by ICLEI

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Emani [ICLEI South Asia Secretariat, Noida (India); Macedo, Laura Valente de [ICLEI Latin America and Caribbean Secretariat, Buenos Aires, DF (Argentina); Staden, Maryke van [ICLEI European Secretariat, Freiburg (Germany)

    2008-07-01

    Local governments (LGs) play a crucial role in implementing local energy policies, ensuring effective regulations, managing assets and providing a wide range of services that impact energy consumption. It is clear that they must also be key players in the transformation to sustainable energy in their communities. The &apos;&apos;{sup local}Renewables Model Communities Network&apos;&apos; (LR), an initiative of ICLEI - Local Governments for Sustainability, to build an international network of communities committed to sustainable energy. The participating cities and towns from developing and developed countries act as role models, and encourage others. LR network communities share information on aspects of sustainable energy, experiences and expertise, from policies to technologies, from stakeholder involvement to implementation processes. LGs around the globe have to become active in the field of sustainable energy. The also require support from various actors, including international cooperation and exchange to support their transition towards sustainable energy solutions. (orig.)

  9. The &apos;Transnuklear affair&apos; and its consequences. Die &apos;Transnuklear-Affaere&apos; und ihre Auswirkungen

    Energy Technology Data Exchange (ETDEWEB)

    Brinkert, M.

    1992-03-01

    The &apos;Bribe&apos; and &apos;Drum&apos; Affairs and suspected proliferation in connection with Transnuklear GmbH public around the turn of 1987/88. Many members of the press wished them to speed up the process of opting out of nuclear power. However, none of the accusations specifically related to nuclear power leveled at that time turned out to be tenable. Instead, all violations of the law which had been detected could have been punished in the same way as in any other branch of industry. As a consequence, the impacts arising to regulatory structures in the nuclear sector, especially the measures taken by the Federal Government, may be considered to have been unjustified in scope. The TN Affair and the associated litigation has caused a great deal of confidence in nuclear power to be lost, which now has to be reclaimed by purposeful public relations efforts. (orig.).

  10. Prospects for neutron star equation of state constraints using &apos;'recycled'&apos; millisecond pulsars

    Energy Technology Data Exchange (ETDEWEB)

    Bogdanov, Slavko [Columbia University, Columbia Astrophysics Laboratory, New York, NY (United States)

    2016-02-15

    &apos;'Recycled'&apos; millisecond pulsars are a variety of rapidly spinning neutron stars that typically show thermal X-ray radiation due to the heated surface of their magnetic polar caps. Detailed numerical modeling of the rotation-induced thermal X-ray pulsations observed from recycled millisecond pulsars, including all relevant relativistic and stellar atmospheric effects, has been identified as a promising approach towards an astrophysical determination of the true neutron star mass-radius relation, and by extension the state of cold matter at densities exceeding those of atomic nuclei. Herein, I review the basic model and methodology commonly used to extract information regarding neutron star structure from the pulsed X-ray radiation observed from millisecond pulsars. I also summarize the results of past X-ray observations of these objects and the prospects for precision neutron star mass-radius measurements with the upcoming Neutron Star Interior Composition Explorer (NICER) X-ray timing mission. (orig.)

  11. The generation and function of soluble apoE receptors in the CNS

    Directory of Open Access Journals (Sweden)

    Rebeck G William

    2006-10-01

    Full Text Available Abstract More than a decade has passed since apolipoprotein E4 (APOE-ε4 was identified as a primary risk factor for Alzheimer 's disease (AD, yet researchers are even now struggling to understand how the apolipoprotein system integrates into the puzzle of AD etiology. The specific pathological actions of apoE4, methods of modulating apolipoprotein E4-associated risk, and possible roles of apoE in normal synaptic function are still being debated. These critical questions will never be fully answered without a complete understanding of the life cycle of the apolipoprotein receptors that mediate the uptake, signaling, and degradation of apoE. The present review will focus on apoE receptors as modulators of apoE actions and, in particular, explore the functions of soluble apoE receptors, a field almost entirely overlooked until now.

  12. Hawai&apos;i&apos;s EVolution: Hawai&apos;i Powered. Technology Driven. (Brochure)

    Energy Technology Data Exchange (ETDEWEB)

    2013-05-01

    This Hawaii Clean Energy Initiative (HCEI) brochure outlines Hawaii&apos;s energy and transportation goals and the implementation of electric vehicles (EV) and electric vehicle infrastructure since HCEI began in 2008. It includes information about Hawaii&apos;s role in leading the nation in available EV charging infrastructure per capita; challenges for continuing to implement EV technology; features on various successful EV users, including the Hawaiian Electric Company, Enterprise Rent-A-Car, and Senator Mike Gabbard; how EVs can integrate into and help propel Hawaii&apos;s evolving smart grid; and much more.

  13. &apos;'Accelerated'&apos; filling of the Inden mine&apos;s residual lake from the Rur river; Die &apos;'beschleunigte'&apos; Befuellung des Tagebaurestsees Inden aus der Rur

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Andreas [RWE Power AG, Koeln (Germany); Koenzen, Uwe [Planungsbuero Koenzen - Wasser + Landschaft, Hilden (Germany); Lohr, Hubert [SYDRO Consult GmbH, Darmstadt (Germany); Hemmann, Regina; Mueller, Vera [Bezirksregierung Koeln, Koeln (Germany); Lange, Joachim [Wasserverband Eifel-Rur, Dueren (Germany)

    2013-03-01

    The Inden opencast lignite mine is located some 20 km to the north-east of Aachen in Germany&apos;s Rhineland. After the end of lignite mining around the year 2030, a lake measuring some 11.8 km{sup 2} is planned to be created. It will mainly be filled with water from the river Rur flowing past in the immediate vicinity of the opencast mine. Filling the lake volume of some 800 million m{sup 3} will take 20 to 25 years. During the past ten years, the basic water management questions arising in connection with the creation of the In den mine&apos;s residual lake were settled within the scope of the state-planning approval procedure.lt could be demonstrated by means of a numeric river catchment model that the envisaged withdrawal of water from the Rur is feasible and compatible with the water body&apos;s ecological and hydromorphological targets as well as its industrial use. (orig.)

  14. Retro-odontoid &apos;'ghost'&apos; pseudotumours in atlanto-axial instability caused by rheumatoid arthritis

    Energy Technology Data Exchange (ETDEWEB)

    Kenez, J. (Dept. of Neurology, Semmelweis Medical Univ., Budapest (Hungary)); Turoczy, L. (Dept. of Neurosurgery, National Inst. of Traumatology, Budapest (Hungary)); Barsi, P. (Dept. of Neurology, Semmelweis Medical Univ., Budapest (Hungary)); Veres, R. (Dept. of Neurosurgery, National Inst. of Traumatology, Budapest (Hungary))

    1993-05-01

    Among 27 cases of marked atlanto-axial instability investigated in the last 10 years we found three with reducible dislocation, in which a cystic &apos;ghost&apos; pseudo-tumours appeared behind the odontoid, maintaining cord compression even in the reduced position, thus influencing the strategy of operative treatment. The cervical spine and the craniocervical region were examined by conventional tomogrpaphy, myelotomography, CT, CT myelography (following melography), and recently in some cases with MRI. (orig./UWA)

  15. Exercícios para tratamento de lombalgia inespecífica

    Directory of Open Access Journals (Sweden)

    Daniele Tatiane Lizier

    2012-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A lombalgia é uma síndrome frequente e provoca incapacidade e perda no trabalho. Apesar de existirem diversas causas, o tipo de lombalgia mais frequente é a inespecífica. Os exercícios são frequentemente empregados para o tratamento da lombalgia porém existem controvérsias quanto a sua eficácia. O objetivo deste texto foi fazer uma revisão sobre exercícios para tratamento de lombalgia inespecífica. CONTEÚDO: Foram descritas a definição e a classificação das lombalgias. A incidência e os mecanismos da lombalgia inespecífica, e os exercícios empregados para seu tratamento foram relatados. CONCLUSÕES: Os tipos de exercícios terapêuticos para lombalgia crônica ou aguda que são mais eficazes, ainda são bastante controversos, contudo exercícios terapêuticos são provavelmente o tratamento conservativo mais usado no mundo todo.

  16. Sintomas de pacientes em tratamento oncológico = Symptoms of patients undergoing oncological treatment

    Directory of Open Access Journals (Sweden)

    Brateibach, Valdecir

    2013-01-01

    Conclusão: O estudo evidencia associação estatística dos sintomas náuseas e vômitos com o ciclo de vida e tratamento, e revela maiores queixas entre as mulheres. Estes dados podem ser utilizados na prática assistencial, auxiliando na individualização da assistência

  17. COMPOSIÇÃO DE CULTIVARES DE SOJA SUBMETIDA A DIFERENTES TRATAMENTOS TÉRMICOS

    Directory of Open Access Journals (Sweden)

    N. C. MOURA

    2008-11-01

    Full Text Available

    A composição centesimal e a presença de fitatos e inibidores de tripsina foram avaliadas nas cultivares de soja Embrapa 48, BRS 212, BRS 214 e BRS 231 submetidas a diferentes tratamentos térmicos (cocção em panela aberta, panela de pressão, microondas e autoclave. Os dados obtidos permitiram a elaboração de rótulo nutricional para os grãos submetidos ao tratamento em panela de pressão. A cocção por microondas preservou a porcentagem de carboidratos e diminuiu o teor de proteínas nas cultivares, com exceção da cultivar BRS 231. Os tratamentos em autoclave e panela de pressão foram os mais eficientes para reduzir os fitatos. O tratamento por microondas foi eficiente para reduzir os inibidores de tripsina em duas cultivares (BRS 212 e BRS 214.

  18. Tratamento da bulimia nervosa: síntese das evidências

    Directory of Open Access Journals (Sweden)

    Bacaltchuk Josué

    1999-01-01

    Full Text Available As duas abordagens terapêuticas mais estudadas para o tratamento da bulimia nervosa (BN são os tratamentos psicológicos, principalmente a terapia cognitivo-comportamental (TCC e o uso de antidepressivos. Os resultados de duas revisões sistemáticas da literatura mostram que a TCC é melhor que fila de espera e que os antidepressivos são superiores ao placebo na remissão a curto prazo dos sintomas bulímicos. A comparação direta das duas abordagens mostra que, quando usados como abordagens exclusivas, a TCC é clinicamente mais eficaz e mais aceita do que os antidepressivos. A associação dos dois tipos de tratamento é clinicamente mais eficaz que cada um isoladamente, mas a aceitação das abordagens psicológicas exclusivas é maior. Como a BN é um transtorno grave e com baixa taxa de remissão espontânea, o tratamento associado, com abordagem multidimensional e multidisciplinar, pode ser indicado.

  19. História dos tratamentos biológicos Biologicals treatments's history

    Directory of Open Access Journals (Sweden)

    Sérgio Paulo Rigonatti

    2004-01-01

    Full Text Available Contexto: Trata-se de uma discussão de como surgiram os tratamentos biológicos no decorrer da história da psiquiatria.Context: It's about a discussion on how begun the biological treatment throughout Psychiatry History.

  20. Iran&apos;s &apos;Risk-Taking&apos; in Perspective

    Energy Technology Data Exchange (ETDEWEB)

    Shahram, Chubin

    2008-07-01

    Assessing any state&apos;s intentions is a difficult undertaking - especially at a specific moment in time. When a state is considered hostile, its behaviour erratic, and its system opaque, what is difficult under normal circumstances becomes nearly impossible. It may thus often seem prudent to attribute the worst of intentions to such states, but this can create a self-fulfilling prophecy. Iran with its revolutionary pretensions, fiery rhetoric and nuclear ambitions, is a case in point, since it is particularly difficult to &apos;read&apos;. Located in the centre of a geo-politically sensitive and conflict-driven area, Iran is in a position to influence - positively or otherwise - the Persian Gulf, the Caucasus, the Middle East and South Asia. This influence may furthermore be expanding as a result of the weakening of Iraq and Lebanon, divisions among the Palestinians, and the more general rise of the Shi&apos;i across the broader region. Add to this the ambiguous aims of Iran&apos;s nuclear programme and the shadow this has already thrown across the region, and the need to assess Iran&apos;s intentions accurately appears crucial. Here, Iran&apos;s past behavior may provide some help, especially when it comes to Iran&apos;s proclivity for risk taking - provided the acquisition of a nuclear capability does not alter Iran&apos;s intentions or behavior so as to make the past irrelevant. Some commentators believe that Iran&apos;s ideology and past behaviour suggest that a nuclear-capable Iran will be inclined to take on a high level of risk, without concern for the potential costs of this recklessness, and that Iran may perhaps even welcome the risks involved. By contrast, the recent National Intelligence Estimate (NIE), a composite of US intelligence agency estimates, has concluded that Iran&apos;s &apos;decisions are guided by a cost-benefit approach&apos; and therefore &apos;may be more vulnerable to influence&apos; than they had previously (i.e.2005) judged. These

  1. Avaliação e Tratamento do Doente com Acne - Parte II: Tratamento Tópico, Sistémico e Cirúrgico, Tratamento da Acne na Grávida, Algoritmo Terapêutico

    OpenAIRE

    A. Figueiredo; Massa, A; Picoto, A; Soares, AP; Basto, AS; Lopes, C; Resende, C; Rebelo, C; Brandão, FM; Marques-Pinto, G; Oliveira, HS; Selores, M.; Gonçalo, Margarida; Bello, RT

    2011-01-01

    O Portuguese Acne Advisory Board (PAAB), grupo de dermatologistas portugueses que, à semelhança de grupos congéneres internacionais, tem dedicado particular atenção à definição de linhas de orientação para o tratamento da acne, pretende que o presente documento constitua uma ferramenta útil na abordagem dos doentes com esta patologia. Elaborou-se um dossier, para educação médica contínua, subdividido em 2 partes: Parte I – etiopatogenia e clínica; Parte II – abordagem terapêutica. Nesta P...

  2. Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.

    Science.gov (United States)

    Klein, Rebecca C; Acheson, Shawn K; Mace, Brian E; Sullivan, Patrick M; Moore, Scott D

    2014-09-01

    The human APOE4 allele is associated with an early age of onset and increased risk of Alzheimer's disease (AD). Apolipoprotein E is secreted as part of a high-density lipoprotein-like particle by glial cells in the brain for the primary purpose of transport of lipophilic compounds involved in the maintenance of synapses. Previous studies examining synaptic integrity in the amygdala of human apoE targeted replacement (TR) mice showed a decrease in spontaneous excitatory synaptic activity, dendritic arbor, and spine density associated with apoE4 compared with apoE3 and apoE2 in adult male mice. In the present study, we assessed how APOE genotype affects synaptic integrity of amygdala neurons by comparing electrophysiological and morphometric properties in human apoE3, E4, and E2/4 TR mice at the age of 18-20 months. In contrast to adult mice, we found that aged apoE4 TR mice exhibited the highest level of excitatory synaptic activity compared with other cohorts. Additionally, apoE4 mice had significantly greater spontaneous inhibitory activity than all other cohorts. Taken together, there was a significant interaction between genotypes when comparing inhibition relative to excitation; there was a simple main effect of frequency type with an imbalance toward inhibition in apoE4 mice but not in apoE3 or apoE2/4 mice. These results suggest that apoE isoforms differentially influence synaptic transmission throughout the life span, where aging coupled with apoE4 expression, results in an imbalance in maintaining integrity of synaptic transmission.

  3. Gastos publicos com medicamentos para o tratamento da osteoporose na pos-menopausa

    Directory of Open Access Journals (Sweden)

    Cristina Mariano Ruas Brandao

    2013-06-01

    Full Text Available OBJETIVO: Analisar os gastos com medicamentos para o tratamento da osteoporose na pós-menopausa e os fatores associados ao gasto médio per capita . MÉTODOS: Pareamento probabilístico-determinístico a partir das bases das Autorizações de Procedimentos de Alta Complexidade com o Sistema de Informação sobre Mortalidade, resultando em coorte histórica de pacientes que utilizaram medicamentos de alto custo para o tratamento da osteoporose na pós-menopausa de 2000 a 2006. O gasto médio mensal com medicamentos foi estratificado por faixas etárias e descrito de acordo com as características demográficas, clínicas e tipo de medicamento utilizado. Foi utilizado modelo de regressão linear para avaliar o impacto de características demográficas e clínicas sobre o gasto médio mensal per capita com os medicamentos. RESULTADOS: Foram identificadas 72.265 mulheres que receberam medicamentos para o tratamento da osteoporose na pós-menopausa. O gasto médio mensal per capita no primeiro ano de tratamento foi de R$ 90,00 (dp R$ 144,49. A maioria das mulheres tinha de 60 a 69 anos de idade, iniciaram tratamento em 2000, eram residentes na região Sudeste, tinham fraturas osteoporóticas prévias e o alendronato de sódio foi o medicamento mais utilizado no início do tratamento. A maioria das pacientes permaneceu em uso do mesmo princípio ativo durante o tratamento. Foram identificados 6.429 óbitos entre as participantes. Mais de um terço das mulheres permaneceram no programa por até 12 meses. Raloxifeno e calcitonina sintética foram as alternativas com maior impacto sobre o gasto médio mensal com medicamentos, tendo como padrão de referência o alendronato de sódio. CONCLUSÕES: Dado o alto impacto do tipo de medicamento utilizado no gasto com medicação, recomenda-se estabelecer critérios para prescrição e dispensação, com prioridade para aqueles com menores custos e maior efetividade. Isso pode otimizar o processo de assist

  4. Impressive Offshore Rig Built &apos;&apos;in the Woods&apos;&apos;. Bentec launched new 2500 hp drilling rig for the Mittelplate field development

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2005-06-01

    In May international rig design and manufacturer Bentec Drilling and Oilfield Systems, a wholly-owned subsidiary of Abbot Group plc, unveiled the new 2500 hp rig T-150 it has been building for the Mittelplate Consortium (RWE Dea AG as operator/Wintershall AG) at Bentec&apos;s manufacturing facility &apos;&apos;in the woods&apos;&apos; of Bad Bentheim, Germany. (orig.)

  5. Why Germany&apos;s &apos;Messy&apos; energy transition should be a lesson to other nations

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Brighton (United Kingdom)

    2015-03-15

    Germany&apos;s so-called &apos;&apos;energy transition&apos;&apos; (&apos;'Energiewende'&apos;) is increasingly drawing the intention of the international community - but it seems for all the wrong reasons. US Senator Lamar Alexander said recently that German energy policy is one of the reasons the US should not abandon nuclear, but actually encourage increased investment in nuclear power plants. Alexander&apos;s remarks were made in an article published by the US Nuclear Energy Institute, in which he outlined his reasons why the US should not follow Germany&apos;s lead. Alexander rightly pointed out that the cost of attempting to replace nuclear power with wind, solar, and accompanying infrastructure is estimated by the German government at some 1.2 trillion US dollars (about 1 trillion Euros). The senator also made the point that Germany &apos;&apos;does not produce enough reliable, baseload energy for an important manufacturing economy&apos;&apos;. He also expressed concern at Germany&apos;s reliance on buying natural gas from Russia. While Germany has been forcing the closure of nuclear power plants others, including the oil-rich United Arab Emirates (UAE), have been investing in new nuclear, Alexander said. Judging from Alexander&apos;s remarks, it seems that Germany&apos;s energy transition experience will, after all, have a long-lasting legacy. That legacy will be a valuable lesson to other major industrialised nations in why they should not follow Germany&apos;s lead in abandoning a sensible energy mix, if they wish to maintain and develop economic and industrial productivity while keeping to international commitments to tackle climate change.

  6. Eletroacupuntura para tratamento de hipotensão induzida por isofluorano em cavalos

    Directory of Open Access Journals (Sweden)

    E.C. Franco

    2014-04-01

    Full Text Available Objetivou-se avaliar a eficiência do tratamento da hipotensão arterial com eletroacupuntura comparativamente à dobutamina em equinos. Foram avaliados seis cavalos adultos, saudáveis, mantidos em anestesia inalatória, com isofluorano, em ventilação mecânica. Após a estabilização da anestesia, foi induzida hipotensão arterial, através do incremento da concentração do isofluorano, iniciando-se um dos tratamentos: DOB: dobutamina (1,5µg kg-1 min-1, infusão contínua intravenosa; EA: estímulo elétrico no acuponto pericárdio 6 (PC6, bilateralmente; SHAM: estímulo elétrico em ponto falso de acupuntura. Foram mensurados: frequência cardíaca (FC, pressão arterial média (PAM, temperatura retal (T, concentração final expirada de isofluorano (ETiso, variáveis hemogasométricas, concentração sérica de aspartato aminotransferase (AST e creatina fosfoquinase (CK, tempo e qualidade da recuperação pós-anestésica. Houve incremento na PAM de 50%, 36,6% e 7,5% nos tratamentos DOB, EA e SHAM, respectivamente. Não houve diferença entre os grupos nas variáveis hemogasométricas, FC, T, ETiso, CK, AST, tempo e qualidade de recuperação pós-anestésica. Conclui-se que o tratamento com dobutamina foi mais efetivo para o tratamento da hipotensão em cavalos sob anestesia inalatória quando comparado ao estímulo elétrico do acuponto PC6 ou ponto falso de acupuntura.

  7. 7th CNS int&apos;l steam generators to controls conference - a compliment to the remarkable CNS &apos;OM+DM utility engagement initiative&apos;

    International Nuclear Information System (INIS)

    We learned from CANDU Maintenance-Conference of December 2011, that it is our own &apos;ways-of-working&apos; as service-providers for everything from plant-architecture to operational-support, that is holding back &apos;new-build&apos; as well as &apos;re-build&apos;. CMC2011 addressed that by focusing on &apos;Needs-and-Interests of the Operating-Utilities&apos;. SGC 2012 extends that by focusing firstly on &apos;Issue-Identification&apos; to isolate &apos;items-needing-attention&apos;; then on &apos;Issue-Definition&apos; to define the &apos;work&apos; required for &apos;Issue-Resolution&apos;. It also pursues &apos;Task Leadership&apos; as a competence, essential for ... &apos;making things happen&apos;. These events and the CNS &apos;OM+DM [Operations&Maintenance and Design&Materials Divisions] Utility Engagement Initiative&apos; are seen as complimentary initiatives toward such &apos;ways-of-working-improvement&apos; objectives. (author)

  8. The synchro crusher: a new type of impact?; Le &apos;'synchro-concasseur'&apos;: du nouveau dans l&apos;impact?

    Energy Technology Data Exchange (ETDEWEB)

    Van der Zanden, H.; Valenchon, P.

    1999-10-01

    The seminar organized by &apos;Quarry Management&apos; on the occasion of the Hillhead 99 workshop provided the Dutch company VanderZanden with the opportunity to present its research work on the development of a new concept of crushing called &apos;SynchroCrusher&apos;. Its principle uses the &apos;relative movement&apos; linked with &apos;synchronization&apos;. Each particle is uniformly and precisely crushed by a double impact, the second impact being only generated by the residual (free) energy and occurring at a greater speed. An optimal direct impact is obtained thanks to a perfect control of the impact angle (between 75 and 85 deg.) and of the particle trajectories with no interference between particles. This system allows to reduce both the energy consumption and the wear of crushers. This paper presents the concept of the SynchroCrusher, its comparison with other classical impact crushers and the R and D work carried out to analyze the movement of particles, the capacity of the crusher with respect to the orientation of blades, the directional changes of particles inside the crusher and the synchronization of particle trajectories. (J.S.)

  9. The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice.

    Science.gov (United States)

    Janssen, Carola I F; Jansen, Diane; Mutsaers, Martina P C; Dederen, Pieter J W C; Geenen, Bram; Mulder, Monique T; Kiliaan, Amanda J

    2016-01-01

    Apolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protects against high-fat (HF) diet induced neurodegeneration by its role in the maintenance of the integrity of the blood-brain barrier. The influence of a HF diet on the progression of AD-like cognitive and neuropathological changes was assessed in wild-type (WT), human ApoE4 and ApoE-knockout (ApoE-/-) mice to evaluate the modulatory role of ApoE in this process. From 12 months of age, female WT, ApoE4, and ApoE-/- mice were fed either a standard or a HF diet (19% butter, 0.5% cholate, 1.25% cholesterol) throughout life. At 15 months of age mice performed the Morris water maze, evaluating spatial learning and memory. ApoE-/- showed increased spatial learning compared to WT mice (p = 0.009). HF diet improved spatial learning in WT mice (p = 0.045), but did not affect ApoE4 and ApoE-/- mice. Immunohistochemical analyses of the hippocampus demonstrated increased neuroinflammation (CD68) in the cornu ammonis 1 (CA1) region in ApoE4 (p = 0.001) and in ApoE-/- (p = 0.032) mice on standard diet. HF diet tended to increase CD68 in the CA1 in WT mice (p = 0.052), while it decreased in ApoE4 (p = 0.009), but ApoE-/- remained unaffected. A trend towards increased neurogenesis (DCX) was found in both ApoE4 (p = 0.052) and ApoE-/- mice (p = 0.068). In conclusion, these data suggest that HF intake induces different effects in WT mice compared to ApoE4 and ApoE-/- with respect to markers for cognition and neurodegeneration. We propose that HF intake inhibits the compensatory mechanisms of neuroinflammation and neurogenesis in aged female ApoE4 and ApoE-/- mice. PMID:27171180

  10. The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice.

    Directory of Open Access Journals (Sweden)

    Carola I F Janssen

    Full Text Available Apolipoprotein E4 (ApoE4, one of three common isoforms of ApoE, is a major risk factor for late-onset Alzheimer disease (AD. ApoE-deficient mice, as well as mice expressing human ApoE4, display impaired learning and memory functions and signs of neurodegeneration. Moreover, ApoE protects against high-fat (HF diet induced neurodegeneration by its role in the maintenance of the integrity of the blood-brain barrier. The influence of a HF diet on the progression of AD-like cognitive and neuropathological changes was assessed in wild-type (WT, human ApoE4 and ApoE-knockout (ApoE-/- mice to evaluate the modulatory role of ApoE in this process. From 12 months of age, female WT, ApoE4, and ApoE-/- mice were fed either a standard or a HF diet (19% butter, 0.5% cholate, 1.25% cholesterol throughout life. At 15 months of age mice performed the Morris water maze, evaluating spatial learning and memory. ApoE-/- showed increased spatial learning compared to WT mice (p = 0.009. HF diet improved spatial learning in WT mice (p = 0.045, but did not affect ApoE4 and ApoE-/- mice. Immunohistochemical analyses of the hippocampus demonstrated increased neuroinflammation (CD68 in the cornu ammonis 1 (CA1 region in ApoE4 (p = 0.001 and in ApoE-/- (p = 0.032 mice on standard diet. HF diet tended to increase CD68 in the CA1 in WT mice (p = 0.052, while it decreased in ApoE4 (p = 0.009, but ApoE-/- remained unaffected. A trend towards increased neurogenesis (DCX was found in both ApoE4 (p = 0.052 and ApoE-/- mice (p = 0.068. In conclusion, these data suggest that HF intake induces different effects in WT mice compared to ApoE4 and ApoE-/- with respect to markers for cognition and neurodegeneration. We propose that HF intake inhibits the compensatory mechanisms of neuroinflammation and neurogenesis in aged female ApoE4 and ApoE-/- mice.

  11. The &apos;night sensitive&apos; vehicle; Das &apos;nachtsensitive&apos; Fahrzeug

    Energy Technology Data Exchange (ETDEWEB)

    Egelhaaf, J.C.; Knoll, P.M. [Robert Bosch GmbH, Leonberg (Germany)

    2003-07-01

    Driver assistance systems help to reduce the number of accidents. In particular, night vision improvement systems can help to come closer to the goal of collision mitigation since 40% of all fatal accidents occur at night while only 20% of traffic happens at night. (Situation in Germany). Besides weather condition, limited vision at night is mainly caused by the light of oncoming vehicles. To overcome this problem, different developments have been made and are going on. Decades ago, an approach using polarized light has been tested but was not pursued longer due to the huge losses of light caused by the polarizers. Adaptive curve light has been introduced in the 1960&apos;s and intelligent headlight systems, adapting the beams of the headlights to specific traffic situations, are under development. A FIR based night vision improvement system is offered as an option in Cadillac cars, and has good market acceptance. The sensor detects the Far Infrared radiation of objects in front of the vehicle and shows them as a Video picture projected on the windscreen with a HUD. At Robert Bosch a NIR based system is currently under development. It uses Near Infrared radiation from the modified halogen headlight. The picture is detected with a Video camera with an imager with high dynamic range, being currently under development. The range of the system is in the range beyond 100 m at good sight (no fog or heavy rain). The advantage of this combination is on the one hand a better performance compared to the FIR system because road limit lines are seen clearly at a wide range and thus a differentiation of objects within or outside the lane can be made. On the other hand the video camera being used for night vision improvement purposes can be used during day time as well, and has a high potential for other vision based safety and comfort functions like lane departure warning (day and night), ACC Stop and Go and others. (orig.)

  12. A Survey of Open Clusters in the u&apos;g'r'i'z&apos; Filter System. 3. Results for the Cluster NGC 188

    Energy Technology Data Exchange (ETDEWEB)

    Fornal, Bartosz; Tucker, Douglas L.; Smith, J.Allyn; Allam, Sahar S.; Rider, Cristin J.; Sung, Hwankyung; /Jagiellonian U. /Fermilab /Austin Peay State U. /Wyoming U. /Johns Hopkins U. /Sejong U.

    2006-11-01

    The authors continue the series of papers describing the results of a photometric survey of open star clusters, primarily in the southern hemisphere, taken in the u&apos;g'r'i'z&apos; filter system. The entire observed sample covered more than 100 clusters, but here they present data only on NGC 188, which is one of the oldest open clusters known in the Milky Way. They fit the Padova theoretical isochrones to the data. Assuming a solar metallicity for NGC 188, they find a distance of 1700 {+-} 100 pc, an age of 7.5 {+-} 0.7 Gyr, and a reddening E(B-V) of 0.025 {+-} 0.005. This yields a distance modulus of 11.23 {+-} 0.14.

  13. The state and means for developing efforts to regulate drilling mud types at the &apos;'Permneft''&apos; union

    Energy Technology Data Exchange (ETDEWEB)

    Krysin, N.I.; Minaeva, R.M.; Sukhikh, U.M.

    1979-01-01

    Service water has been most widely used as a drilling mud at the &apos;'Permneft''&apos; union. Emulsion mud and emulsion mud-carbonated drilling mud are also widely used. In unstable rock areas, flushing is conducted using calcium chloride mud drilling solutions and mud drilling solutions with natural subsalt mineralization. The use of various types of drilling muds is analyzed. The following were the primary indicators in the analysis: the specific weight of the expenditures on drilling solution materials in the overall cost of borehole construction and the expenses on materials for 1 meter of drilling. The types of drilling solutions recommended for use in different fields in specific geological conditions are determined. The drilling solution standards are compared based on the results of an analysis and the reference materials of the All-Union Scientific Research Institute on Comprehensive Oil Solutions. An examination proceedure is described, together with the regulation acceptances and directions for improving them.

  14. The effects of the apoE4 genotype on the developing mouse retina.

    Science.gov (United States)

    Maharshak, Idit; Salomon-Zimri, Shiran; Antes, Ran; Liraz, Ori; Nisgav, Yael; Livnat, Tami; Weinberger, Dov; Colton, Carol A; Solomon, Arieh S; Michaelson, Daniel M

    2016-04-01

    Apolipoprotein E4 (apoE4), the most prevalent genetic risk factor for Alzheimer's disease (AD), is associated with neuronal and vascular impairments. The retina, which is as an extension of the central nervous system (CNS), is a particularly suitable model for studying developmental and functional aspects of the neuronal and vascular systems. This study investigates the apoE4-dependent developmental effects on the retinal vasculature and neuronal systems and on the levels of apoE and the vascular endothelial growth factor (VEGF) in the retina. This was performed utilizing retinas of 4, 7, 12, and of 120-day-old human-apoE4-targeted replacement mice and of corresponding mice that express the AD benign isoform, apoE3. The results obtained revealed retinal vascular pathology in the apoE4 mice, which started on the early post-natal days. This includes transient increase in vascular branching, and vascular buds which are round vascular elements representing sprouting or retracting vessels. These effects peaked and ended during the neonatal period. Examination of the synaptic system utilizing the pre-synaptic marker synaptophysin revealed a significant decrease of retinal synaptic density in the apoE4 mice, which was detectable by post-natal day 12 (P12). These morphological changes are associated with neonatal age-dependent elevation in the apoE levels in both apoE3 and apoE4 retinas which is more profound in the apoE4 mice and a corresponding increase in VEGF levels, which is less profound in the apoE4 mice. Additionally, we observed lower levels of retinal VEGF in the apoE4 mice compared to the apoE3 mice retinas on P12. These results show that apoE4 has a transient vascular effect during retinal development that ends in the neonatal period, which is accompanied by a synaptic effect that begins at the end of the neonatal period. These findings show that the apoE4 genotype can have distinct developmental effects on both the retinal vasculature and on neurons and

  15. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

    Directory of Open Access Journals (Sweden)

    Benfeard Williams

    2015-10-01

    Full Text Available The increased risk of developing Alzheimer's disease (AD is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 and ApoE2 are considered to be the AD-neutral and AD-protective isoforms, respectively. It has been hypothesized that the ApoE isoforms may contribute to the development of AD by modifying the homeostasis of ApoE physiological partners and AD-related proteins in an isoform-specific fashion. Here we find that, despite the high sequence similarity among the three ApoE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific domain-domain interactions in molecular dynamics simulations. The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by altering multiple cellular pathways involved in ApoE-dependent lipid transport efficiency or in AD-related protein aggregation and clearance. We present what we believe to be the first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the molecular mechanism underlying the role of ApoE4 in AD pathogenesis. The knowledge of the structure for the ApoE4 folding intermediate provides a new platform for the rational design of alternative therapeutic strategies to fight AD.

  16. ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.

    Science.gov (United States)

    Williams, Benfeard; Convertino, Marino; Das, Jhuma; Dokholyan, Nikolay V

    2015-10-01

    The increased risk of developing Alzheimer's disease (AD) is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the strongest risk factor for AD onset, while ApoE3 and ApoE2 are considered to be the AD-neutral and AD-protective isoforms, respectively. It has been hypothesized that the ApoE isoforms may contribute to the development of AD by modifying the homeostasis of ApoE physiological partners and AD-related proteins in an isoform-specific fashion. Here we find that, despite the high sequence similarity among the three ApoE variants, only ApoE4 exhibits a misfolded intermediate state characterized by isoform-specific domain-domain interactions in molecular dynamics simulations. The existence of an ApoE4-specific intermediate state can contribute to the onset of AD by altering multiple cellular pathways involved in ApoE-dependent lipid transport efficiency or in AD-related protein aggregation and clearance. We present what we believe to be the first structural model of an ApoE4 misfolded intermediate state, which may serve to elucidate the molecular mechanism underlying the role of ApoE4 in AD pathogenesis. The knowledge of the structure for the ApoE4 folding intermediate provides a new platform for the rational design of alternative therapeutic strategies to fight AD.

  17. Reflection group on &apos;Expert Culture&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Eggermont, G

    2000-07-01

    As part of SCK-CEN&apos;s social sciences and humanities programme, a reflection group on &apos;Expert Culture&apos; was established. The objectives of the reflection group are: (1) to clarify the role of SCK-CEN experts; (2) to clarify the new role of expertise in the evolving context of risk society; (3) to confront external views and internal SCK-CEN experiences on expert culture; (4) to improve trust building of experts and credibility of SCK-CEN as a nuclear actor in society; (5) to develop a draft for a deontological code; (6) to integrate the approach in training on assertivity and communication; (7) to create an output for a topical day on the subject of expert culture. The programme, achievements and perspectives of the refection group are summarised.

  18. Outline of year-round ski facility &apos;LALAPORT SKI DOME &apos;SSAWS'&apos;. Lalaport ski dome &apos;SSAWS&apos; no keikaku gaiyo

    Energy Technology Data Exchange (ETDEWEB)

    Kayo, M. (Kajima Corp., Tokyo (Japan)); Suzuki, T. (NKK Corp., Tokyo (Japan))

    1994-03-31

    This paper introduces the world&apos;s first indoor snow-fall type artificial ski facility &apos;SSAWS&apos;. Skiing can be enjoyed throughout a year by virtue of artificial snow making machines. Snow quality control requires that the temperature in the ski slope be kept below the freezing point at all times. Means to achieve the requirement included reducing outer wall load by using heat insulation, recovering waste heat from the ski slope by using heat pipes, preventing cold air from leaking and outside air from entering, and adopting a cogeneration system. The cold heat source is a warm water absorbing freezer utilizing waste heat from a gas engine for the cogeneration. The cogeneration system has saved more than 60% of the air conditioning and hot water supplying energy, reducing the annual expense by 15%. The snow making system has a nozzle jet out very highly homogeneous and microfine water droplets with compressed air, and freeze them at -5[degree]C utilizing adiabatic expansion into snow to fall on the slope. The system can control the snow quality as required. The floor of the ski slope is in contact with atmosphere, where snow melting progresses from the lower part as a result of temperature gradient. Therefore, neither special heat source is required, nor a work to scrape and remove the snow that has been stained. 4 refs., 11 figs.

  19. Tratamento cirúrgico para claudicação intermitente em pacientes que não melhoram com o tratamento clínico

    Directory of Open Access Journals (Sweden)

    Wolosker Nelson

    2004-01-01

    Full Text Available OBJETIVO: Estudar prospectivamente os resultados obtidos com o tratamento cirúrgico de portadores de claudicação intermitente que não obtiveram melhora clínica com o tratamento conservador, acompanhados, em média, por 6 anos. MÉTODOS: De janeiro/1992 a janeiro/2002 foram acompanhados 26 pacientes tratados cirurgicamente de um grupo de 1380 portadores de claudicação intermitente, admitidos num ambulatório de doença arterial obstrutiva periférica e claudicação intermitente, representando 1,88% do total. RESULTADOS: Não referiam limitação para deambular após a cirurgia 16 pacientes. Experimentaram melhora nove, porém com algum grau de limitação, e dois, pequena melhora na distância máxima de marcha. Não houve mortalidade intra-operatória. Três pacientes apresentaram trombose da artéria tratada 6,48 e 60 meses após o procedimento e passaram a apresentar claudicação intermitente para as distâncias prévias à cirurgia. Durante o seguimento a longo prazo observamos uma mortalidade de 23,0% devido a infarto agudo do miocárdio (4 casos, insuficiência renal (um e acidente vascular cerebral (um. Dois pacientes foram submetidos a revascularização do miocárdio 2 e 4 anos após a reconstrução arterial e um ainda necessitou angioplastia coronariana com 3 anos de seguimento. O tempo de seguimento médio foi de 73 meses. CONCLUSÃO: O tratamento cirúrgico diminuiu sintomas isquêmicos da claudicação intermitente em muitos pacientes, com excelente taxa de patência (88,4% dos enxertos, tornando-se em pacientes que não apresentam melhora com tratamento clínico, boa alternativa com baixas taxas de complicações e bons resultados a longo prazo.

  20. The role of APOE in cerebrovascular dysfunction.

    Science.gov (United States)

    Tai, Leon M; Thomas, Riya; Marottoli, Felecia M; Koster, Kevin P; Kanekiyo, Takahisa; Morris, Alan W J; Bu, Guojun

    2016-05-01

    The ε4 allele of the apolipoprotein E gene (APOE4) is associated with cognitive decline during aging, is the greatest genetic risk factor for Alzheimer's disease and has links to other neurodegenerative conditions that affect cognition. Increasing evidence indicates that APOE genotypes differentially modulate the function of the cerebrovasculature (CV), with apoE and its receptors expressed by different cell types at the CV interface (astrocytes, pericytes, smooth muscle cells, brain endothelial cells). However, research on the role of apoE in CV dysfunction has not advanced as quickly as other apoE-modulated pathways. This review will assess what aspects of the CV are modulated by APOE genotypes during aging and under disease states, discuss potential mechanisms, and summarize the therapeutic significance of the topic. We propose that APOE4 induces CV dysfunction through direct signaling at the CV, and indirectly via modulation of peripheral and central pathways. Further, that APOE4 predisposes the CV to damage by, and exacerbates the effects of, additional risk factors (such as sex, hypertension, and diabetes). ApoE4-induced detrimental CV changes include reduced cerebral blood flow (CBF), modified neuron-CBF coupling, increased blood-brain barrier leakiness, cerebral amyloid angiopathy, hemorrhages and disrupted transport of nutrients and toxins. The apoE4-induced detrimental changes may be linked to pericyte migration/activation, astrocyte activation, smooth muscle cell damage, basement membrane degradation and alterations in brain endothelial cells. PMID:26884068

  1. A model for economical integration of &apos;&apos;Green power&apos;&apos; into the grid. VDE-Study &apos;Smart Distribution 2020&apos;; Ein Modell fuer die wirtschaftliche Integration von Oekostrom ins Netz. VDE-Studie &apos;Smart Distribution 2020&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Jopp, Klaus

    2008-07-01

    The model of this study motivates &apos;'green'&apos; power generation due to the demand in the frame of virtual power plants, therefore the connection of green power generators regulated consumers and power storage. Conditions for virtual power plants is an &apos;&apos;Apollo program&apos;&apos; for an armament to the grids by information- and communication technologies as investigation on advanced storage engineering. With special efforts Germany should be able to play a leading role on intelligent grid management, which may be developed as an import hit. (GL)

  2. ApoE Isoform-Dependent Deficits in Extinction of Contextual Fear Conditioning

    OpenAIRE

    Olsen, Reid H. J.; Agam, Mati; Davis, Matthew James; Raber, Jacob

    2012-01-01

    The three major human apoE isoforms (apoE2, apoE3, and apoE4) are encoded by distinct alleles (ε2, ε3, and ε4). Compared to ε3, ε4 is associated with increased risk to develop Alzheimer’s disease (AD), cognitive impairments in Parkinson’s disease (PD), and other conditions. In contrast, a recent study indicated an increased susceptibility to the recurring and re-experiencing symptom cluster of Post Traumatic Stress Disorder (PTSD), as well as related memory impairments, in patients carrying a...

  3. &apos;&apos;Rio+20 on site&apos;&apos;. Communities on their way to sustainability. Examples from Germany; &apos;&apos;Rio+20 vor Ort&apos;&apos;. Kommunen auf dem Weg zur Nachhaltigkeit. Beispiele aus Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Nolting, Katrin; Goell, Edgar

    2012-03-15

    20 years ago, the international community adopted the concept of &apos;sustainable development&apos; as a model for the 21st century adopted in order to meet the growing challenges facing the mankind. With Agenda 21, the UN presented a global action plan for the implementation of such a sustainable development. This brochure provides an insight into sustainability activities at local level in Germany. It is shown how such activities result in future-oriented and exemplary developments in some areas and selected areas of action.

  4. &apos;Biomoleculas&apos;: cellular metabolism didactic software

    Energy Technology Data Exchange (ETDEWEB)

    Menghi, M L [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina); Novella, L P [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina); Siebenlist, M R [Chair of Physiology and Biophysics, Facultad de Ingenieria, Universidad Nacional de Entre Rios, CC 57 Suc 3, Parana 3100, Entre Rios (Argentina)

    2007-11-15

    &apos;Biomoleculas&apos; is a software that deals with topics such as the digestion, cellular metabolism and excretion of nutrients. It is a pleasant, simple and didactic guide, made by and for students. In this program, each biomolecule (carbohydrates, lipids and proteins) is accompanied until its degradation and assimilation by crossing and interrelating the different metabolic channels to finally show the destination of the different metabolites formed and the way in which these are excreted. It is used at present as a teaching-learning process tool by the chair of Physiology and Biophysics at the Facultad de Ingenieria - Universidad Nacional de Entre Rios.

  5. Qualidade de vida de pacientes hipertensos em tratamento ambulatorial Quality of life of hypertensive patients treated at an outpatient clinic

    OpenAIRE

    Margaret Assad Cavalcante; Maria Teresa Nogueira Bombig; Braulio Luna Filho; Antonio Carlos Camargo Carvalho; Angelo A. V. de Paola; Rui Póvoa

    2007-01-01

    FUNDAMENTO: As doenças cardiovasculares são principal causa de mortalidade na população brasileira, sendo a hipertensão arterial (HA) de maior prevalência. A terapêutica para o tratamento da HA é cada vez maior e sabe-se que melhora a sobrevida dos pacientes, porém questiona-se a melhora na qualidade de vida (QV) do paciente hipertenso após tratamento. OBJETIVO: Comparar aspectos relacionados à QV de pacientes hipertensos em tratamento. MÉTODOS: Foram estudados 100 pacientes hipertensos; 46 a...

  6. Tratamento cognitivo e comportamental para transtornos do controle de impulsos Cognitive-behavioral treatment for impulse control disorders

    OpenAIRE

    Hodgins, David C; Nicole Peden

    2008-01-01

    OBJETIVOS: Este artigo revisa o tratamento da cleptomania, do comprar compulsivo e do jogo patológico. MÉTODO: Realizou-se uma revisão da literatura publicada. RESULTADOS: A pesquisa sobre o tratamento em todas essas áreas é limitada. As técnicas cognitivo-comportamentais utilizadas no tratamento da cleptomania compreendem sensibilização encoberta, dessensibilização imaginal, dessensibilização sistemática, terapia de aversão, treinamento de relaxamento e fontes alternativas de satisfação. Com...

  7. Optimisation of biological reactors using the &apos;biological resonance&apos; phenomenon; Ansatz zur Optimierung biologischer Reinigungsstufen durch das Phaenomen der &apos;&apos;Biologischen Resonanz&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, A.

    2003-07-01

    The microbial catabolic activity of biological reactors can be increased by up to 75% through external stimulation with intermittent stress loads at intervals of several minutes. Under these process conditions, the &apos;&apos;biological resonance&apos;&apos; phenomenon determines the system and leads to an increased synthesis of enzymes. In addition to computer simulations, experiments with activated sludge were carried out in a 10-litre bioreactor. By modulating the stress intervals, a permanent increase in catabolic activity of about 60% was achieved during these experiments. By relying on the &apos;&apos;biological resonance&apos;&apos; phenomenon, the required reaction volume of biological treatment units can probably be reduced by up to 40%. (orig.)

  8. Cuts in energy and operating cost with the Swiss system &apos;Energie in ARA&apos; - practical experience in Germany; Energie- und Betriebskosteneinsparungen nach dem schweizerischen System &apos;&apos;Energie in ARA&apos;&apos; - Praxiserfahrungen in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Christmann, B. [UmBAUwelt Partnerschaft Architekten und Ingenieure, Riedstadt (Germany)

    1999-07-01

    German sewage treatment plants, too, have potential for saving energy cost and cutting down on their operating expenditure. Following the systematy developed by the &apos;Energie in ARA&apos; concept, this potential can be harnessed. (orig.) [German] Potential fuer Energiekosteneinsparungen und dadurch initiierte Betriebskosteneinsparungen ist auch bei deutschen Klaeranlagen vorhanden. Die Systematik &apos;Energie in ARA&apos; kann fuer die Erschliessung der Einsparpotentiale verwendet werden. (orig.)

  9. ApoE mimetic peptide decreases Aβ production in vitro and in vivo

    Directory of Open Access Journals (Sweden)

    Pak Daniel TS

    2010-04-01

    Full Text Available Abstract Background Apolipoprotein E (apoE is postulated to affect brain Aβ levels through multiple mechanisms--by altering amyloid precursor protein (APP processing, Aβ degradation, and Aβ clearance. We previously showed that an apoE-derived peptide containing a double repeat of the receptor-binding region was similarly effective in increasing APP processing in vivo. Here, we further examined whether peptides containing tandem repeats of the apoE receptor-binding region (amino acids 141-149 affected APP trafficking, APP processing, and Aβ production. Results We found that peptides containing a double or triple tandem repeat of the apoE receptor-binding region, LRKLRKRLL, increased cell surface APP and decreased Aβ levels in PS1-overexpressing PS70 cells and in primary neurons. This effect was potentiated by a sequential increase in the number of apoE receptor-binding domain repeats (trimer > dimer > monomer. We previously showed that the apoE dimer increased APP CTF in vivo; to determine whether the dimer also affected secreted APP or Aβ levels, we performed a single hippocampal injection of the apoE dimer in wild-type mice and analyzed its effect on APP processing. We found increased sAPPα and decreased Aβ levels at 24 hrs after treatment, suggesting that the apoE dimer may increase α-secretase cleavage. Conclusions These data suggest that small peptides consisting of tandem repeats of the apoE receptor-binding region are sufficient to alter APP trafficking and processing. The potency of these peptides increased with increasing repeats of the receptor binding domain of apoE. In addition, in vivo administration of the apoE peptide (dimer increased sAPPα and decreased Aβ levels in wild-type mice. Overall, these findings contribute to our understanding of the effects of apoE on APP processing and Aβ production both in vitro and in vivo.

  10. 2001-2003 &apos;&apos;public utility&apos;&apos; contract between the French government and Gaz de France; Contrat de &apos;&apos;service public&apos;&apos; 2001-2003 entre l&apos;etat et Gaz de France

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    The &apos;&apos;public utility&apos;&apos; contract aims at specifying the actions of Gaz de France (GdF), the French gas utility, in terms of national development and public utility presence at the local scale. It extends and completes the &apos;contract of group&apos; established between the government and GdF in the domain of quality of the services offered to clients, development of gas infrastructures and extension of gas supplies, and sustainable development. (J.S.)

  11. OPEC&apos;s strategies

    Energy Technology Data Exchange (ETDEWEB)

    Wirl, Franz [Vienna Univ. (Austria). Faculty of Business, Economics and Statistics

    2012-09-15

    This paper investigates rationale explanations of OPEC&apos;s strategies. Accounting for market characteristics in particular the sluggishness of demand and supply allows to explain price jumps as rational OPEC strategies from a narrow economic perspective (up and down) as well as from political objectives (at least up) due to the political payoff from standing up against the &apos;West&apos;. Although the temptation to accrue this political payoff was and remains high, the narrow economic profit motive coupled with an imperfect cooperation among OPEC members explains past price volatility and high prices much better than the usual reference to political events. A more specific prediction is that OPEC will switch back to setting prices since the current quantity strategy encourages oil importing countries to appropriate rents in particular in connection with the need to mitigate global warming. (orig.)

  12. Vertigo Imaging; Clinical Radiology&apos;

    Directory of Open Access Journals (Sweden)

    Jalal Jalal Shokouhi

    2009-01-01

    Full Text Available   "n- Dizziness that patients complain from are rotational vertigo, sense of instability, ataxia of gait, disturbance of vision, loss of contact with surroundings, nausea, loss of memory, loss of confidence, epileptic convulsion and dizziness that is considered by medical staff are: "n1- Vertigo as a sense of feeling the environment moving when it does not persist in all positions, aggravated by head movement. "n2- Disequilibrium as a feeling of unsteadiness or insecurity without rotation, standing and walking are difficult. "n3- Light headedness as swimming, floating, giddy or swaying sensation in the head or in the room. "nTaking the history from a vertigo patient:* "n            What the patient means by vertigo?- "n- Time of onset "n-Temporal pattern "n-Associated signs and symptoms &apos;&apos; tinnitus, hearing loss, headache, double vision, numbness and difficulty in swallowing &apos;&apos;. "n- Precipitating, aggravating and relieving factors. "n- If episodic: sequence of events, activity at onset, aura, severity and amnesia. "n*Examination of the vertigo patient checking: "nSpontaneous nystagmus, positional nystagmus, optokinetic nystagmus, posture and balance control like romberg&apos;s test, blind walking, untenberger and barany&apos;s test, stimulation of labyrinth, caloric test &apos;&apos; cold, warm water &apos;&apos; and the rotational test. "nEtiology : "n*Spontaneous nystagmus: "nPosture and balance control is positive with nausea , vomiting , sweating and anxiety : harmonic vestibular sy with loss of hearing , tinnitus , vestibular neuronitis , meniere disease and with otologic origin and dysharmmonic vestibular sy , with numbness , double vision , dysarthria in brain stem infarct and with a neurological origin. "nNonspontaneous nystagmus :Posture and balance negative with nausea, vomiting in GI disorders and internal medicine , sweating and trachycardia by chest pain in angina , M.I &apos;&apos; cardiology &apos;&apos

  13. Cash management system &apos;CEREUS-SM&apos;; Supermarket muke kinsen shoriki &apos;CEREUS-SM&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Niizuma, N.; Fukushima, Y.; Kinoshita, S. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-03-10

    The adjustment system with change in coin has reduced cashier work in supermarkets, and has spread as the standard peripheral equipment of the point of sales (POS) system. Recently, there have been customer needs for a type with change in bill and coin. Fuji Electric has developed cash management system &apos;CEREUS-SM&apos; which is as small as the current system only with change in coin and can be handled by anyone, including a part-timer or a student worker. (author)

  14. Crisis - Weisskopf&apos;s view

    International Nuclear Information System (INIS)

    &apos;We are facing a crisis, not only in particle physics but in the whole of fundamental science&apos;, said Victor Weisskopf, doyen of quantum physics, during his traditional summer CERN stopover. &apos;Basic science - science for its own sake - and especially high energy physics, is really in danger.&apos; As well as explaining how this has come about, the former CERN Director General (1961-5) proposed action to reverse the trend. Rather than dividing science into the conventional &apos;big&apos; and &apos;small&apos; camps, he slices across another axis. On one hand there is obviously applicable &apos;terrestrial science&apos; - biology, medicine, solid state, much of the nuclear sector, nonlinear behaviour, chaos,....all directly connected with processes that happen on Earth. On the other there is &apos;cosmic science&apos; - astronomy, astrophysics, particle physics and some of the nuclear sector - addressing deeper issues, not attainable naturally on this planet at all, and where applications are less immediately obvious. (This classification is not completely watertight - even cosmic science can, and does, foster immediate spinoff, Weisskopf points out, citing Georges Charpak&apos;s detector work.) Tracing the evolution of science in this century, Weisskopf sees the rapid evolution of American influence in the 1930s as a turning point. Before then, the United States had not been in the front line, and it had been important for US researchers to spend some time in Europe

  15. The role of the &apos;&apos;Neutral Service Provider&apos;&apos; in the liberalised gas market; Die Rolle des &apos;&apos;Neutral Service Provider&apos;&apos; im liberalisierten Erdgasmarkt

    Energy Technology Data Exchange (ETDEWEB)

    Peper, F.; Greverath, I. [Viavera GmbH Dortmund (Germany)

    2002-07-01

    The ongoing liberalisation of European gas markets forces network operators as well as retail companies to implement new processes. This article focuses on the challenges for network operators. In this context the potential for &apos;Neutral Service Providers (NSP)&apos; is discussed. Based on sample TPA processes the interaction between the NSP and the network operator is explored. The authors conclude that for many market participants the outsourcing of TPA processes to a specialized service provider has the potential to deliver significant benefits. (orig.) [German] Die fortschreitende Liberalisierung der europaeischen Erdgasmaerkte stellt die Netz- sowie die Vertriebsgesellschaften vor staendig wachsende Anforderungen. Dabei wird in diesem Artikel der Schwerpunkt auf die Komplexitaet der Aufgaben insbesondere fuer Netzbetreiber gelegt. In diesem Zusammenhang werden die hieraus resultierenden Marktchancen fuer neue Dienstleistungsunternehmen, die sogenannten &apos;Neutral Service Provider&apos; (NSP) eroertert. Anhand eines Prozessbeispiels wird die Interaktion zwischen NSP und den von ihm betreuten Netzbetreibern diskutiert. Die Autoren kommen zu dem Schluss, dass fuer viele Marktteilnehmer die Auslagerung bestimmter Unternehmensaktivitaeten im Zusammenhang mit der Bewaeltigung des Netzzugangs Dritter an einen spezialisierten Dienstleister mit erheblichen Vorteilen verbunden ist. (orig.)

  16. &apos;Blueprint&apos; your pulverizer for improved performance

    Energy Technology Data Exchange (ETDEWEB)

    Storm, R.F. [Storm Technologies Inc. (United States)

    2009-03-15

    Pulverizer throughput is determined by the coal fineness desired for a given coal. However, compromising on coal fineness when your pulverizer isn&apos;t up to scratch can increase NOx and cause many furnace problems. Your least costly option for increasing pulverizer capacity is to pay careful attention to key dimensions and critical tolerances during your next overhaul. 11 figs.

  17. Scenarios for the popular initiatives &apos;Strom ohne Atom&apos; (Electricity without nuclear power) and &apos;Moratorium Plus&apos;; Szenarien zu den Initiativen &apos;Strom ohne Atom&apos; sowie &apos;MoratoriumPlus&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Eckerle, K.; Haker, K.; Hofer, P

    2001-07-01

    This report for the Swiss Federal Office of Energy (SFOE) presents the results of a study made on the possible effects of two Swiss Popular Initiatives which called for the shutdown of nuclear power stations in Switzerland (&apos;Strom ohne Atom&apos;), the restriction of their operating life and the abstention from building new atomic power stations (&apos;Moratorium Plus&apos;). The report examines the energetic and financial consequences of the initiatives. The approaches used for the analysis are described and the energy policy actions required to avoid gaps in the supply of power after the possible closure of the power stations are discussed. Apart from a reference scenario (long-term utilisation of nuclear energy), scenarios for power generation using co-generation are presented. The problems posed by the resulting CO{sub 2} and NO{sub x} emissions are discussed. Further scenarios review the contribution to be made by renewable sources of energy and increasing energy-conservation efforts. The costs of the shutdown of nuclear power stations are discussed and the results of a sensitivity analysis are presented.

  18. Efeito adverso do uso intermitente de rifampicina para tratamento de hanseníase

    Directory of Open Access Journals (Sweden)

    Priscila Maria de Oliveira Papaiordanou

    1988-10-01

    Full Text Available Os autores apresentam um caso de insuficiência renal aguda, hemólise aguda e trombocitopenia relacionada ao uso intermitente de Rifampicina para tratamento da Hanseníase. Estas reações adversas são observadas com extrema raridade na literatura mundial. A evolução da paciente foi benigna havendo recuperação total da função renal e regressão completa das alterações hematológicas. Este foi o primeiro registro no Brasil dos efeitos adversos da Rifampicina no tratamento de Hanseníase. São discutidos os principais aspectos patogênicos das alterações apresentadas e fez-se revisão da literatura existente sobre o assunto.

  19. Psicoterapia interpessoal no tratamento da perturbação depressiva maior

    Directory of Open Access Journals (Sweden)

    Catarina Oliveira Lucas

    2012-08-01

    Full Text Available A terapia interpessoal é um modelo de terapia breve formulado para o tratamento da perturbação depressiva maior, tendo como precursores Gerald Klerman e Mirna Weissman. Esta visa o alívio dos sintomas associados à depressão abordando os problemas interpessoais que os originaram e perpetuam. Esta modalidade de terapia refere as perturbações como resultantes da existência de problemas numa das quatro áreas interpessoais principais: luto, transição de papéis, disputas de papéis interpessoais e défices interpessoais. Deste modo, a terapia incidirá na área afectada. Esta demonstra bons indicadores de eficácia e apesar de formulada para o tratamento da depressão, a terapia interpessoal tem sido adaptada e expandida a outras perturbações.

  20. Tratamento do derrame pleural parapneumônico em crianças

    OpenAIRE

    Cat, Rubens

    2007-01-01

    Resumo: Introdução: Pneumonia continua sendo a principal causa infecciosa de morte na população pediátrica, com aproximadamente 4 milhões de óbitos ao ano. Sua principal complicação é o derrame pleural, presente em até 80% dos casos fatais. Não existe consenso quanto ao seu tratamento ideal. Objetivos: Definir, por meio de ecografia torácica no momento da internação, a indicação do tratamento cirúrgico precoce para diminuir o tempo de hospitalização de crianças com derrame pleural parapneumôn...

  1. Tratamento cirúrgico da siringomielia pela Técnica de Gardner

    Directory of Open Access Journals (Sweden)

    Gilberto M. Almeida

    1973-12-01

    Full Text Available O tratamento cirúrgico da siringomielia é, em geral, considerado decepcionante. Vários tipos de drenagem da cavidade siringomiélica não têm fornecido resultados satisfatórios. Gardner, em magnífica série de trabalhos, mostrou que a siringomielia e as várias malformações associadas à hidrocefalia têm fisiopatogenia única. Baseado em sua teoria, Gardner propôs, em 1958, o bloqueio da comunicação entre o IV ventrículo e o canal central da medula, para o tratamento da siringomielia. Esta técnica não tem sido realizada com muita freqüência. Empregamos o método proposto por Gardner em 4 pacientes, os quais melhoraram após a intervenção cirúrgica.

  2. Os objetos e o tratamento da criança autista

    Directory of Open Access Journals (Sweden)

    Ariana Lucero

    2015-12-01

    Full Text Available Resumo O objetivo deste artigo é refletir sobre o uso dos objetos na direção de tratamento psicanalítico da criança autista. Primeiramente, teceremos algumas considerações a respeito da importância do objeto na constituição subjetiva, a partir da oposição freudiana entre os princípios de prazer e de realidade. A seguir, retomaremos as considerações de Frances Tustin sobre o objeto autístico e o caso Joey, de Bruno Bettelheim, para exemplificarmos como autores clássicos da psicanálise teorizaram sobre o objeto no tratamento. Por fim, discutiremos com autores contemporâneos a importância de uma retomada da noção de objeto no âmbito da teoria e da prática psicanalíticas.

  3. Terapia génica no tratamento da doença de Parkinson

    OpenAIRE

    Fontes, Albina de Jesus Ventura

    2011-01-01

    Dissertação de mest., Ciências Farmacêuticas, Faculdade de Ciências e Tecnologia, Univ. do Algarve, 2011 A presente dissertação aborda o tratamento da doença de Parkinson através da Terapia Génica. A doença de Parkinson é uma doença neurodegenerativa progressiva que manifesta-se principalmente na idade adulta. Actualmente o tratamento convencional é farmacológico e sintomático ou por estimulação cerebral, no caso de perda de eficácia dos fármacos. Os fármacos utilizados não curam,...

  4. Uso do octreotide no tratamento do quilotórax e quiloperitôneo

    Directory of Open Access Journals (Sweden)

    Cristiane Felix Ximenes Pessotti

    2011-08-01

    Full Text Available Relato de três casos de quilotórax e um caso de ascite quilosa em crianças em pós-operatório de cirurgia cardíaca, que evoluíram sem resposta ao tratamento clínico habitual, baseado em jejum e nutrição parenteral prolongada. Tratamento com octreotide na dose inicial de 1,0 mcg/kg/h foi escolhido, com aumento progressivo de 1,0 mcg/kg/h/dia até a dose máxima de 4,0 mcg/kg/h. Todos os casos tiveram resposta favorável, com redução progressiva do débito do dreno, até resolução do quadro, sem efeito colateral significativo.

  5. Experiências com o Antihelmíntico BB-04 no tratamento de helmintoses intestinais

    Directory of Open Access Journals (Sweden)

    Léa Camillo-Coura

    1971-04-01

    Full Text Available Os autores apresentam os resultados da associação piperazina-tiabendazol-dimetilpolisiloxane no tratamento de infecções por helmintos intestinais. Os resultados vieram confirmar a apreciável eficácia da piperazina e do tiabendazol para o tratamento da ascaridíase e da ancilostomíase nas doses utilizadas. Houve cura de 50% dos 82 casos de ancilostomíase, de 41% dos 72 de ascaridiase e de 26% dos 76 portadores de infecção pelo Trichuris trichiura. Observou-se regressão da sintomatologia na maioria dos casos após instituída a terapêutica, especialmente dor abdominal, diarréia e obstipação. A tolerância ao medicamento foi considerada boa.

  6. CONSERVAÇÃO DE PERAS MINIMAMENTE PROCESSADAS SUBMETIDAS A TRATAMENTOS QUÍMICOS

    OpenAIRE

    ANA CAROLINA VILAS BOAS; PAÔLA DE CASTRO HENRIQUE; LUIZ CARLOS DE OLIVEIRA LIMA; MICHEL CARDOSO DE ANGELIS PEREIRA

    2015-01-01

    RESUMO O trabalho teve como objetivo testar a eficácia de tratamentos químicos na manutenção da qualidade de peras ‘Williams’ minimamente processadas. Inicialmente, realizaram-se a lavagem, a sanitização e a retirada das sementes dos frutos. Em seguida, foram realizados cortes no formato de palitos, e os mesmos foram imersos nas soluções, compondo os tratamentos: ácido ascórbico a 2 % (controle); ácido ascórbico a 2% + cloreto de cálcio a 2%; ácido ascórbico a 2% + ácido cítrico a 2%; ácido ...

  7. Comportamento da eosinofilia após o tratamento das geohelmintoses

    Directory of Open Access Journals (Sweden)

    Marta Maria Bozóti

    1973-04-01

    Full Text Available A eosinofilia sanguínea após o tratamento anti-helmíntico específico se comportou numa amostragem de 57 crianças da seguinte forma: .Na ascaridíase isolada ou associada à trieuríase a hipereosinofilia parasitária ou descia uniformemente após o tratamento, ou houve primeiro uma exacerbação que durava até a terceira semana após a erradicação da, parasitose, descendo em seguida. Em ambos os casos houve normalização do hemograma em dois meses. Na associação ascaridíase/ancilostomíase também são possíveis dois tipos de comportamento da eosinofilia após tratamento eficaz: ou vai diminuindo a hipereosinofilia, logo em seguida à expulsão dos parasitos, ou há no primeiro mês um aumento da hipereosinofilia (geralmente mais acentuado na primeira semana que se segue ao tratamento, para diminuir após o fim do primeiro mês progressivamente até desaparecer. Na estrongiloidíase e na associação ascaridíase/estrongiloidíase há diminuição constante da hipereosinofilia logo após o tratamento e o hemograma se normaliza em cerca de dois meses. Na trieuríase, a hipereosinofilia, aliás já discreta, diminui pouco com o tratamento. Na ancilostomíase e na associação ancilostomíase/trieuríase a hipereosinofilia ou desce após o tratamento gradativo e lentamente, ou primeiro há uma exaltação temporária nas primeiras três semanas após a terapêutica, para diminuir em seguida. Na associação ancilostomíase/estrongiloidíase também se encontram esses dois tipos de comportamento da hipereosinofilia verminótica, mas a exacerbação da hipereosinofilia, que ocorre na metade dos casos, só dura duas semanas; a regressão eosinofílica ocorre dois meses após o tratamento. Nas tri e tetraeparasitoses a involução pós-terapêutica da hipereosinofilia é irregular e a normalização das taxas sanguíneas de eosinófilos é sempre arrastada, principalmente nas associações ascaridíase/estrongiloidíase/ancilostomíase e

  8. Alguns vegetais brasileiros empregados no tratamento da diabetes Some Brazilian plants employed in diabetes treatment

    OpenAIRE

    Fernando de Oliveira; Maria Lucia Saito

    1989-01-01

    Os autores mencionam 17 plantas medicinais brasileiras frequentemente empregadas no tratamento de diabetes fornecendo dados sobre a composição química, elabora­ção das formas farmacêuticas empregadas e a posologia utilizada.The outhors present 17 Brazilian medicinal plants frequently employed as hypoglycaemiant in diabetes treatment The chemical composition, preparation of pharmaceutical forms and posology of these plants are presented.

  9. Necessidades básicas das esposas de pacientes infartados na fase aguda do tratamento

    Directory of Open Access Journals (Sweden)

    Edna Ikumi Umebayashi Takahashi

    1990-12-01

    Full Text Available Trata-se de um estudo exploratório que teve por finalidade as necessidades básicas das esposas de pacientes infartados, na fase aguda do tratamento. Foi utlizado como referencial para análise os conceitos de Nacessidades Básicas de MASLOW. Os resultados permitiram identificar como principais necessidades afetadas das esposas: segurança, amor e gregária, estima.

  10. Paralisia de Bell: fisiopatologia e tratamento = Bell’s palsy: physiopathology and treatment

    Directory of Open Access Journals (Sweden)

    Falavigna, Asdrubal

    2008-01-01

    Conclusões: a fisiopatologia da paralisia de Bell ainda permanece não bem esclarecida, embora tenha sido demonstrada associação com a presença do vírus Herpes simplex. O seu tratamento permanece controverso, no entanto recentes ensaios clínicos bem conduzidos confirmam o benefício dos corticosteróides

  11. Divertículo faringoesofagiano: avaliação dos resultados do tratamento

    Directory of Open Access Journals (Sweden)

    Maria Aparecida Coelho de Arruda Henry

    2013-04-01

    Full Text Available OBJETIVO: Avaliar a evolução pós-operatória de pacientes com divertículo faringoesofagiano submetidos aos tratamentos cirúrgico e endoscópico. MÉTODOS: Foram analisados de maneira retrospectiva 36 pacientes com divertículo faringo-esofagiano atendidos no Hospital das Clínicas da Faculdade de Medicina de Botucatu - UNESP. Os pacientes foram distribuídos em dois grupos, na dependência do tratamento: grupo 1 (n=24 - diverticulectomia associada á miotomia do cricofaríngeo, através de cervicotomia esquerda; grupo 2 (n=12 - diverticulostomia endoscópica usando grampeador linear. RESULTADOS: A mortalidade operatória foi nula em ambos os grupos. Complicações precoces: grupo 1 - dois pacientes desenvolveram fistula cervical e outros dois, rouquidão; grupo 2 - sem complicações. Complicações tardias: grupo 1 - sem complicações: grupo 2: recidiva da disfagia em quatro pacientes (p=0,01. O seguimento médio foi 33 meses para o grupo 1 e 28 meses para o grupo 2. CONCLUSÃO: Os dois procedimentos foram eficazes na remissão da disfagia. O tratamento cirúrgico apresentou superioridade em relação ao endoscópico, com resolução da disfagia com um único procedimento. O tratamento endoscópico deve ser reservado para os mais idosos e portadores de comorbidades.

  12. Effects of nocturnal aircraft noise on sleep: results from the &apos;&apos;quiet air traffic&apos;&apos; project; Wirkungen des Nachtfluglaerms auf den Schlaf: Ergebnisse aus dem Projekt &apos;&apos;Leiser Flugverkehr&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Samel, A.; Basner, M.; Maass, H.; Mueller, U.; Quehl, J.; Wenzel, J. [Deutsches Zentrum fuer Luft- und Raumfahrt (DLR) in der Helmholtz-Gemeinschaft (HGF), Inst. fuer Luft- und Raumfahrtmedizin, Koeln (Germany)

    2005-07-01

    In 192 sleep-healthy subjects (18 to 65 y) effects of nocturnal aircraft noise on sleep, stress, performance and subjective factors were investigated in 2240 nights under laboratory and field conditions. In the sleep lab, 112 volunteers were subjected to aircraft noise events by varying numbers and noise levels during 9 nights within a period of 13 nights. 16 further subjects served as control group (i.e. without any noise). 64 subjects were studied in the vicinity of Cologne-Bonn airport during 9 nights. Polysomnographical and acoustical recordings, determination of excretion rates of stress hormones from night urines, performance tests and questionnaires were conducted during all days for the assessment of nocturnal aircraft noise effects. By simultaneous recording of electrophysiological and acoustical data the probability of noise induced awakenings was estimated. Performance and most of psychological parameters did not show significant dose-effect relationships, whereas annoyance did. Epinephrine and norepinephrine did not change under aircraft noise, cortisol did change only in the lab. In the lab, a comparison between all noisy nights and noise-free baseline nights exhibited a non-significant 2-min. reduction of sleep and a 4-min. decrease of slow-wave sleep. In the field, awakenings caused by aircraft noise were detected above a threshold of 33 dB(A) &apos;&apos;at the sleeper&apos;s ear&apos;&apos;. All effects were much less pronounced in the field than in the lab. For the first time, precise dose-effect curves between maximum aircraft noise event levels and electrophysiologically detectable awakenings, and a threshold were empirically established. The results of these studies broadens the knowledge on aircraft noise induced sleep disturbances and immediate consequences for the next day. (orig.)

  13. The effects of apoA-I/C-III/A-IV, apoE and apoB polymorphisms on carotid artery intima-media thickness.

    Science.gov (United States)

    Nieminen, Tuomo; Kähönen, Mika; Lehtimäki, Terho

    2006-03-01

    Different apolipoprotein combinations explain most of the functional differences between plasma lipoproteins. This emphasizes the pivotal role of apolipoproteins in the homeostasis and physiological control of lipid metabolism. Genetic polymorphisms of apolipoprotein (apo)A-I/C-III/A-IV, apoE and apoB have been suggested to modulate plasma lipid levels as well as the risk of coronary artery disease and stroke. Carotid artery intima-media thickness has been shown to represent preclinical atherosclerosis and has, therefore, been used as a surrogate in quantifying the early stages of atherosclerosis. The effects of the polymorphisms in apoA-I/C-III/A-IV and apoB on carotid intima-media thickness are poorly known. The corresponding influence of apoE polymorphisms has been studied more extensively, but the results are not yet conclusive. In this review, these results are presented in detail and the potential reasons and mechanisms for the discrepancies are discussed. PMID:19804074

  14. Avaliação e tratamento da hiperglicemia em pacientes graves

    Directory of Open Access Journals (Sweden)

    Marina Verçoza Viana

    2014-03-01

    Full Text Available A hiperglicemia é um problema frequentemente encontrado em pacientes graves em ambiente de terapia intensiva. Sua presença se associa ao aumento da morbidade e da mortalidade, independentemente da causa da admissão (infarto agudo do miocárdio, condição após cirurgia cardiovascular, acidente vascular cerebral e sepse. Entretanto, permanecem muitas dúvidas com relação à fisiopatologia e, particularmente, em relação ao tratamento da hiperglicemia no paciente graves. Na prática clínica, devem ser levados em consideração diversos aspectos para o controle desses pacientes, inclusive os alvos de glicemia, o histórico de diabetes mellitus, a via de nutrição (enteral ou parenteral e o equipamento de monitoramento disponível, o que aumenta substancialmente a carga de trabalho dos profissionais envolvidos nesse tratamento. Esta revisão descreveu a epidemiologia, a fisiopatologia, o tratamento e o monitoramento da hiperglicemia no paciente adulto grave.

  15. Tratamento microcirúrgico de aneurismas da artéria comunicante anterior

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Mendes Faleiro

    1973-12-01

    Full Text Available Os autores descrevem o tratamento microcirúrgico realizado em oito pacientes que tiveram hemorragia subaracnóidea espontânea por rotura de aneurisma da artéria comunicante anterior. A conduta clínica pré-operatória é apresentada sendo dada ênfase às condições do paciente antes do ato cirúrgico. A técnica cirúrgica é descrita em detalhe, sendo salientado o uso do microscópio binocular. Dos 8 pacientes, dois (25% tinham mais de um aneurisma que foram tratados durante a mesma operação. A única complicação cirúrgica foi meningite pós-operatória em um paciente; esta complicação cedeu completamente ao tratamento. Após a operação 88% dos pacientes retornaram ao seu trabalho, não tendo havido óbito em virtude do tratamento.

  16. Adesão ao tratamento da Hanseníase: dificuldades inerentes aos portadores

    Directory of Open Access Journals (Sweden)

    Izaildo Tavares Luna

    2010-12-01

    Full Text Available Esta pesquisa, realizada em Guaiúba, CE, Brasil, objetivou identificar as dificuldades de adesão ao tratamento pelos portadores de hanseníase, relacionando os fatores associados. Estudo qualitativo, cujos dados foram coletados a partir de uma visita domiciliária com roteiro de entrevista contendo sete questões norteadoras. Participaram pacientes com diagnóstico de hanseníase e histórico de não adesão ao tratamento. Utilizou-se o Modelo de Atividade de Vida de Roper, Logan e Tierney. As falas dos sujeitos foram categorizadas de acordo com as doze atividades de vida. A utilização do modelo possibilitou uma abordagem holística sobre as barreiras vivenciadas pelo hanseniano na adesão ao tratamento medicamentoso, de modo a conhecer as atividades de vida destes pacientes para possível adequação de ações voltadas a essa clientela.

  17. PROTOCOLOS DE TRATAMENTO FISIOTERÁPICO APÓS CIRURGIA DO LIGAMENTO CRUZADO ANTERIOR

    Directory of Open Access Journals (Sweden)

    Thaís Sá Pimenta

    2015-12-01

    Full Text Available O ligamento cruzado anterior (LCA é uma das estruturas que compõe a articulação do joelho. As lesões do LCA estão ocorrendo com frequência e está é suscetível a lesões em desportos de contato. A perda deste ligamento gera instabilidade anterior do joelho podendo limitar a capacidade funcional, sobrecarregar os estabilizadores secundários e limitar a atividade esportiva do individuo, assim a indicação cirúrgica no tratamento da lesão do LCA vem sendo um consenso. Desta forma, este estudo tem por objetivo apresentar variados protocolos de tratamento após cirurgia de reparação deste ligamento. Embora todos os protocolos encontrados foquem o mesmo objetivo de dar ao paciente as mesmas capacidades funcionais comparativamente ao membro não operado, neste estudo podemos concluir que as opções de tratamento são numerosos com relação as condutas fisioterápicas e os conhecimentos sobre patologias do joelho sofreram grande avanço e por consequência vários protocolos ainda vêm sendo desenvolvidos, e a recuperação do paciente deve sempre focar no objetivo e levar sempre em conta a profissão, o esporte, o estilo de vida e a idade do paciente na escolha do protocolo.

  18. Toxina botulínica como tratamento para fobia social generalizada com hiperidrose

    Directory of Open Access Journals (Sweden)

    Larissa da Rocha Lessa

    2011-01-01

    Full Text Available CONTEXTO: Enrubescimento, tremores e transpiração excessiva são fenômenos frequentemente observados na fobia social. OBJETIVOS: Descrever a resposta de um paciente com o tipo generalizado de fobia social e hiperidrose à terapia cognitivo-comportamental aliada à toxina botulínica. MÉTODO: Relato de caso único. RESULTADOS: O Sr. A, 20 anos, estudante universitário, procurou tratamento por apresentar sintomas compatíveis com os diagnósticos de fobia social e depressão. O Sr. A também apresentava diagnóstico de hiperidrose palmar, plantar e axilar. Tanto a fobia social quanto a hiperidrose tiveram seu início no começo da adolescência, com a primeira se iniciando quatro anos antes da segunda. A terapia cognitivo-comportamental levou à remissão da depressão, mas o tratamento efetivo da fobia social apenas foi possível após a terapia com a toxina botulínica. CONCLUSÃO: A toxina botulínica, um tratamento que bloqueia fenômenos autonômicos periféricos, também pode proporcionar alívio dos sintomas em pacientes com fobia social.

  19. Espondilodiscites sépticas: diagnóstico e tratamento

    Directory of Open Access Journals (Sweden)

    Leal Francisco Sérgio C. Barros

    2003-01-01

    Full Text Available Estudamos retrospectivamente 24 pacientes com espondilodiscite séptica de diferentes etiologias (hematogênica, primária e infantil e os diferentes aspectos envolvidos em seu diagnóstico e tratamento. Constatamos que a velocidade de hemossedimentação é um bom parâmetro laboratorial para acompanhar a evolução da doença, mas deve ser sempre interpretada conjuntamente com o quadro clínico e os achados de neuroimagem. Biópsias devem ser reservadas para os casos de diagnóstico duvidoso e o tratamento clínico realizado sempre que afastadas as seguintes condições: sepse, déficit neurológico, deformidade severa, abscesso epidural e corpo estranho (discite primária. A abordagem cirúrgica deve ser planejada levando em conta o estágio da doença, sendo preferencialmente por via posterior nas fases supurativas e anterior nas demais. Baseados em nossa experiência e em revisão da literatura, propomos um algoritmo para orientar o diagnóstico e o tratamento das espondilodiscites sépticas.

  20. Tratamento videolaparoscópico da hérnia inguinal em meninos = Laparoscopic treatment of inguinal hernia in boys

    Directory of Open Access Journals (Sweden)

    Faria, Adyr Eduardo Virmond

    2008-01-01

    Conclusões: a técnica videolaparoscópica mostrou-se efetiva, segura e com baixa incidência de complicações no tratamento cirúrgico da hérnia inguinal em meninos. Acredita-se que o tratamento videolaparoscópico das hérnias inguinais em meninos seja um método alternativo válido em relação à cirurgia tradicional

  1. Conference: &apos;Heating with Wood&apos;. An alternative to fossil fuels? Status and perspectives. Documentation; Tagung: &apos;Heizen mit Holz&apos;. Eine Alternative zur fossilen Energie? Stand der Technik und neue Perspektiven. Dokumentation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    Main topics of the meeting &apos;&apos;Heating with wood&apos;&apos; were: resource assessment, economical aspects, logistics, cogeneration, district heating, plantation and harvesting of fast growing trees, new heating systems.(uke)

  2. Introducing Human APOE into Aβ Transgenic Mouse Models

    Directory of Open Access Journals (Sweden)

    Leon M. Tai

    2011-01-01

    Full Text Available Apolipoprotein E (apoE and apoE/amyloid-β (Aβ transgenic (Tg mouse models are critical to understanding apoE-isoform effects on Alzheimer's disease risk. Compared to wild type, apoE−/− mice exhibit neuronal deficits, similar to apoE4-Tg compared to apoE3-Tg mice, providing a model for Aβ-independent apoE effects on neurodegeneration. To determine the effects of apoE on Aβ-induced neuropathology, apoE−/− mice were crossed with Aβ-Tg mice, resulting in a significant delay in plaque deposition. Surprisingly, crossing human-apoE-Tg mice with apoE−/−/Aβ-Tg mice further delayed plaque deposition, which eventually developed in apoE4/Aβ-Tg mice prior to apoE3/Aβ-Tg. One approach to address hAPOE-induced temporal delay in Aβ pathology is an additional insult, like head injury. Another is crossing human-apoE-Tg mice with Aβ-Tg mice that have rapid-onset Aβ pathology. For example, because 5xFAD mice develop plaques by 2 months, the prediction is that human-apoE/5xFAD-Tg mice develop plaques around 6 months and 12 months before other human-apoE/Aβ-Tg mice. Thus, tractable models for human-apoE/Aβ-Tg mice continue to evolve.

  3. Solar tank. &apos;Solar ship&apos; and solar development project at Freiburg; Sonne im Tank. &apos;Sonnenschiff&apos; und Solarsiedlung in Freiburg

    Energy Technology Data Exchange (ETDEWEB)

    Alle, N.

    2007-05-15

    In the &apos;Vauban&apos; district of the German city of Freiburg, 59 plusenergy terrace houses and one block of offices and shops were constructed during the past five years. The latter is named &apos;solar ship&apos; and has nine penthouses on its roof which generate more power than they consume. The building is 125 m long and is both a building and a power station. (orig.)

  4. Inorganic profile of some Brazilian medicinal plants obtained from ethanolic extract and &apos;&apos;in natura&apos;&apos; samples

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, M.O.M.; de Sousa, P.T.; Salvador, V.L.R.; Sato, I.M.

    2004-10-03

    The Anadenathera macrocarpa, Schinus molle, Hymenaea courbaril, Cariniana legalis, Solidago microglossa and Stryphnodendron barbatiman, were collected &apos;&apos;in natura&apos;&apos; samples (leaves, flowers, barks and seeds) from different commercial suppliers. The pharmaco-active compounds in ethanolic extracts had been made by the Mato Grosso Federal University (UFMT). The energy-dispersive x-ray fluorescence (ED-XRF) spectrometry was used for the elemental analysis in different parts of the plants and respective ethanolic extracts. The Ca, Cl, Cu, Fe, K, Mg, Mn, Na, Ni, P, Rb, S, Sr and Zn concentrations were determined by the fundamental parameters method. Some specimens showed a similar inorganic profile for &apos;&apos;in natura&apos;&apos; and ethanolic extract samples and some ones showed a distinct inorganic profile. For example, the Anadenathera macrocarpa showed a similar concentration in Mg, P, Cu, Zn and Rb elements in &apos;&apos;in natura&apos;&apos; and ethanolic extract samples; however very different concentration in Na, S, Cl, K , Ca, Mn, Fe and Sr was observed in distinctive samples. The Solidago microglossa showed the K, Ca, Cl, S, Mg, P and Fe elements as major constituents in both samples, suggesting that the extraction process did not affect in a considerable way the &apos;&apos;in natura&apos;&apos; inorganic composition. The elemental composition of the different parts of the plants (leaves, flowers, barks and seeds) has been also determined. For example, the Schinus molle specimen showed P, K, Cl and Ca elements as major constituents in the seeds, Mg, K and Sr in the barks and Mg, S, Cl and Mn in the leaves, demonstrating a differentiated elementary distribution. These inorganic profiles will contribute to evaluate the quality control of the Brazilian herbaceous trade and also will assist to identify which parts of the medicinal plants has greater therapeutic effect.

  5. Proposal of a simple screening method for a rapid preliminary evaluation of &apos;&apos;heavy metals&apos;&apos; mobility in soils of contaminated sites

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Valentina; Chiusolo, Francesca; Cremisini, Carlo [ENEA - Italian Agency for New Technologies, Energy and Environment, Rome (Italy). Section PROTCHIM

    2010-09-15

    Risks associated to &apos;&apos;heavy metals&apos;&apos; (HM) soil contamination depend not only on their total content but, mostly, on their mobility. Many extraction procedures have been developed to evaluate HM mobility in contaminated soils, but they are generally time consuming (especially the sequential extraction procedures (SEPs)) and consequently applicable on a limited number of samples. For this reason, a simple screening method, applicable even &apos;&apos;in field&apos;&apos;, has been proposed in order to obtain a rapid evaluation of HM mobility in polluted soils, mainly focused on the fraction associated to Fe and Mn oxide/hydroxides. A buffer solution of trisodium citrate and hydroxylamine hydrochloride was used as extractant for a single-step leaching test. The choice of this buffered solution was strictly related to the possibility of directly determining, via titration with dithizone (DZ), the content of Zn, Cu, Pb and Cd, which are among the most representative contaminants in highly mineralised soils. Moreover, the extraction solution is similar, aside from for the pH value, which is the one used in the BCR SEP second step. The analysis of bivalents ions through DZ titration was exploited in order to further simplify and quicken the whole procedure. The proposed method generically measures, in few minutes, the concentration of total extractable &apos;&apos;heavy metals&apos;&apos; expressed as molL{sup -1} without distinguishing between elements. The proposed screening method has been developed and applied on soil samples collected from rural, urban and mining areas, representing different situation of soil contamination. Results were compared with data obtained from the BCR procedure. The screening method demonstrated to be a reliable tool for a rapid evaluation of metals mobility. Therefore, it could be very useful, even &apos;&apos;in field&apos;&apos;, both to guide the sampling activity on site and to monitor the efficacy of the subsequent

  6. Re-evaluation of the criticality experiments of the &apos;&apos;Otto Hahn Nuclear Ship&apos;&apos; reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lengar, I.; Snoj, L.; Rogan, P.; Ravnik, M. [Jozef Stefan Institute, Ljubljana (Slovenia)

    2008-11-15

    Several series of experiments with a FDR reactor (advanced pressurized light water reactor) were performed in 1972 in the Geesthacht critical facility ANEX. The experiments were performed to test the core prior to its usage for the propulsion of the first German nuclear merchant ship &apos;'Otto-Hahn'&apos;. In the present paper a calculational re-evaluation of the experiments is described with the use of the up-to date computer codes (Monte-Carlo code MCNP5) and nuclear data (ENDF/B-VI release 6). It is focused on the determination of uncertainties in the benchmark model of the experimental set-up, originating mainly from the limited set of information still available about the experiments. Effects of the identified uncertainties on the multiplication factor were studied. The sensitivity studies include parametric variation of material composition and geometry. The combined total uncertainty being found 0.0050 in k{sub eff}, the experiments are qualified as criticality safety benchmark experiments. (orig.)

  7. Final Report on Project 01-ERD-017 &apos;&apos;Smart Nanostructures From Computer Simulations&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Grossman, J C; Williamson, A J

    2004-02-13

    This project had two main objectives. The first major goal was to develop new, powerful computational simulation capabilities. It was important that these tools have the combination of the accuracy needed to describe the quantum mechanical nature of nanoscale systems and the efficiency required to be applied to realistic, experimentally derived materials. The second major goal was to apply these computational methods to calculate and predict the properties of quantum dots--initially composed of silicon, but then of other elements--which could be used to build novel nanotechnology devices. The driving factor of our purpose has been that, through the development and successful application of these tools, we would generate a new capability at LLNL that could be used to make nanostructured materials &apos;'smarter'&apos;, e.g., by selectively predicting how to engineering specific, desired properties. To carry out the necessary work to successfully complete this project and deliver on our goals, we established a two-pronged effort from the beginning: (1) to work on developing new, more efficient algorithms and quantum simulation tools, and (2) to solve problems and make predictions regarding properties of quantum dots which were being studied experimentally here at Livermore.

  8. Aerosol activity distribution on aerodynamic diameter inside the object &apos;'Shelter'&apos;: physical and dosimetric aspects

    Energy Technology Data Exchange (ETDEWEB)

    Bondarenko, O.A.; Aryasov, P.B.; Medvedev, S.Yu.; Nesmiyan, I.M. [Radiation Protection Inst., Kiev (Ukraine); Zhidkov, A.V. [ISTC ' ' Shelter' ' , Chernobyl, Kiev (Ukraine)

    2001-07-01

    Experimental results of the aerosol size distribution inside the Object &apos;'Shelter'&apos; are evaluated in the work. The results show a consistent and significant contribution of sub-micron fraction to the total aerosol activity. Different methods of interpretation of impactor data series are evaluated in terms of adequate assessment of the separate sub-micron aerosol fraction. The contribution of the sub-micron component to the total aerosol activity was found to be about 35%. Results of this research were also compared to those of other authors conducted with by using identical impactor equipment, e.g. results of aerosol sampling at a Czech NPP Dukovany. It is demonstrated in the work that observation of such a significant contribution of the sub-micron fraction for the Shelter aerosol can be hardly explained by systematic failure of the sampling equipment. Also physical mechanisms and corresponding observations of sub-micron aerosol generation inside the Shelter as well as subsequent dosimetric aspects are discussed. (orig.)

  9. &apos;'Green'&apos; Biopolymers for Improved Decontamination of Metals from Surfaces: Sorptive Characterization and Coating Properties

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Brian H.; Kuritz, Tanya

    2000-06-01

    The proposed research aims to develop a fundamental understanding of important biological and physical chemical parameters for effective decontamination of metal surfaces using environmentally benign aqueous-based biopolymer solutions. Understanding how heavy metal-chelating biopolymers coat and interact with contaminated surfaces will benefit the development of novel, safe, easy-to-apply decontamination methodologies for removal of radionuclides and heavy metals. The benefits of these methodologies will include the following: (1) decreased exposure hazards for workers; (2) decreased secondary waste generation; (3) increased efficiency of decontamination; (4) positive public appeal and development of novel, nature-friendly business opportunities; and (5) lower cost of cleanup to the government. We propose to use aqueous biopolymer solutions to coat a contaminated metal surface (i.e., steel), solubilize the heavy metals (e.g., uranium) from the surface, and bind the heavy metals into the biopolymer. The biopolymer coating (containing the immobilized hazardous metal contaminants) will then be removed as a viscous film, as a dry powder, or by washing. This &apos;&apos;apply, wait, and remove&apos;&apos; procedure will reduce the amount of worker time spent in decontamination activities.

  10. &apos;'Green'&apos; Biopolymers for Improved Decontamination of Metals from Surfaces: Sorptive Characterization and Coating Properties

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Brian H.; Kurtiz,Tanya

    1999-06-01

    The proposed research aims to develop a fundamental understanding of important biological and physical chemical parameters for effective decontamination of metal surfaces using environmentally benign aqueous-based biopolymer solutions. Understanding how heavy metal-chelating biopolymers coat and interact with contaminated surfaces will benefit the development of novel, safe, easy-to-apply decontamination methodologies for removal of radionuclides and heavy metals. The benefits of these methodologies will include the following: (1) decreased exposure hazards for workers; (2) decreased secondary waste generation; (3) increased efficiency of decontamination; (4) positive public appeal and development of novel, nature-friendly business opportunities; and (5) lower cost of cleanup to the government. We propose to use aqueous biopolymer solutions to coat a contaminated metal surface (i.e., steel), solubilize the heavy metals (e.g., uranium) from the surface, and bind the heavy metals into the biopolymer. The biopolymer coating (containing the immobilized hazardous metal contaminants) will then be removed as a viscous film, as a dry powder, or by washing. This &apos;&apos;apply, wait, and remove&apos;&apos; procedure will reduce the amount of worker time spent in decontamination activities.

  11. &apos;'Green'&apos; Biopolymers for Improved Decontamination of Metals from Surfaces: Sorptive Characterization and Coating Properties

    Energy Technology Data Exchange (ETDEWEB)

    Davison, Brian H.

    2002-04-30

    The proposed research aimed to develop a fundamental understanding of important biological and physical chemical parameters for effective decontamination of metal surfaces using environmentally benign aqueous-based biopolymer solutions. Understanding how heavy metal-chelating biopolymers coat and interact with contaminated surfaces will benefit the development of novel, safe, easy-to-apply decontamination methodologies for removal of radionuclides and heavy metals. The benefits of these methodologies include the following: decreased exposure hazards for workers; decreased secondary waste generation; increased efficiency of decontamination; positive public appeal and development of novel, nature-friendly business opportunities; and lower cost of cleanup to the government. We proposed to use aqueous biopolymer solutions to coat a contaminated metal surface (i.e., steel), solubilize the heavy metals (e.g., uranium) from the surface, and bind the heavy metals into the biopolymer. The biopolymer coating (containing the immobilized hazardous metal contaminants) was to be removed as a viscous film, as a dry powder, or by washing. This &apos;&apos;apply, wait, and remove&apos;&apos; procedure will reduce the amount of worker time spent in decontamination activities.

  12. Comment on &apos;&apos;Functional integral for Weyl fermions and the effective action&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Banerjee, R.; Banerjee, H.

    1989-02-15

    Baaklini&apos;s method of obtaining the effective action for Weyl fermions is shown to yield either a gauge-invariant or a gauge-variant form depending on the specific definition employed in the analysis. The structures of the effective action proposed by Baaklini are found to correspond to the standard expressions.

  13. Imaging of bridging vein thrombosis in infants with abusive head trauma: the &apos;&apos;Tadpole Sign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Hahnemann, Maria L.; Kinner, Sonja; Schweiger, Bernd [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Bajanowski, Thomas [University Hospital Essen, Institute of Legal Medicine, Essen (Germany); Karger, Bernd; Pfeiffer, Heidi; Wittschieber, Daniel [University Hospital Muenster, Institute of Legal Medicine, Muenster (Germany)

    2014-10-03

    Abusive head trauma (AHT) in infants is usually diagnosed using a multi-disciplinary approach by investigating the circumstances and identifying morphological indicators, for example, subdural hematomas (SDHs), subdural hygromas (SDHys), retinal haemorrhages and encephalopathy. The present morphological study investigates the incidence, radiological characteristics and non-radiological co-factors of bridging vein thrombosis (BVT) in infants with AHT. From 2002 to 2013, computed tomography (CT) and magnetic resonance imaging (MRI) material of 628 infants aged 0-2 years were analysed retrospectively. If available, medicolegal expert opinions were additionally considered. Cases with SDHs and/or SDHys were identified and systematically evaluated as to the presence and characteristics of BVT. SDHs and/or SDHys were present in 29 of the 81 cases exhibiting morphological abnormalities in the initial CT. Among these, 11 cases (40 %) had BVT (mean age = 5.0 months). BVT could be best depicted in the T1-weighted spin echo and T2*/susceptibility-weighted MRI. In one case, BVT could be depicted indirectly using time-of-flight MR venography. The predominant (73 %) BVT shape was found to be tadpole-like (&apos;&apos;Tadpole Sign&apos;&apos;). In the absence of appropriate accidental trauma, BVT appears to be a strong indicator of AHT. Therefore, the BVT/Tadpole Sign represents compelling cause to search for other signs of AHT. (orig.)

  14. Resource consumption of Germany - indicators and definitions. Development of a glossary on the concept of &apos;'resources'&apos; and calculation of missing characteristic data of resources consumption for further political analysis; Ressourcenverbrauch von Deutschland - aktuelle Kennzahlen und Begriffsbestimmungen. Erstellung eines Glossars zum &apos;'Ressourcenbegriff'&apos; und Berechnung von fehlenden Kennzahlen des Ressourcenverbrauchs fuer die weitere politische Analyse

    Energy Technology Data Exchange (ETDEWEB)

    Schuetz, Helmut; Bringezu, Stefan [Wuppertal Institut fuer Klima, Umwelt, Energie GmbH, Wuppertal (Germany). Forschungsgruppe 3: Stoffstroeme und Ressourcenmanagement

    2008-02-15

    The goals of the reported study are: - to prepare a glossary on the term &apos;'Resources'&apos; in order to support communication based on a harmonised resource term and associated terms and - to provide key data on resource use in Germany in time series since 1991 up to the most recent year for which data were available (2004 in general), and to attribute results to the resource terms. Results achieved are presented and discussed below by the following sections: Provision of a glossary on the term &apos;'resource'&apos;, use of the term &apos;'resource'&apos; at different levels, and provision of data and derived indicators for resource consumption in time series. First, a list of the relevant publications in the topic field &apos;'resources'&apos; was provided and co-ordinated with the client. This publication list is given in the annex to this report. On basis of national and international sources a glossary was provided which clearly describes and comments the resource term, its sub-terms and associated terms. This glossary is in the annex to this report. (orig.)

  15. Estudo imunológico da esquistossomose mansoni intestinal antes e após tratamento com aminonitrotiazol

    Directory of Open Access Journals (Sweden)

    Lucyr Jones Antunes

    1974-02-01

    Full Text Available Foram dosadas as imunoglobulinas e realizados testes cutâneos para se avaliar o sistema imunológico de pacientes portadores da forma intestinal da esquistossomose mansoni. Estes testes foram realizados antes do tratamento com aminonitrotiazol e após trinta, sessenta e noventa dias do tratamento. Antes do tratamento o nível de IgG (1893 ± 472 mg% apresentava-se elevado, mas os níveis de IgA (186 ± 74 mg% e de IgM (91 ± 26 mg% achavam-se normais. Decorridos trinta, sessenta e noventa dias do tratamento, o nível de IgG diminuiu, observando-se ligeira elevação de IgA bem como de IgM. Os pacientes, antes do tratamento, quando testados com schistosomina e anti IgE apresentaram áreas de 1,22 ± 0,36 cm² e 1,04 ± 0,25 cm², respectivamente. Noventa dias após o tratamento, as reações à schistosomina e ao soro anti IgE produziram reações com áreas ainda maiores. Os testes de hipersensibilidade retardada mostraram que 35% dos pacientes reagiram à schistosomina e 71% ao 2-4 dinitrofluorobenzeno.

  16. Solar passive building &apos;Working and Living&apos; in Freiburg, Vauban. Final report; Solar-Passivhaus &apos;Wohnen und Arbeiten&apos;, Freiburg, Vauban. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Wittwer, V.; Voss, K.

    2001-03-30

    Objective of the project: The apartment house called &apos;&apos;living and working&apos;&apos; in the conversion area &apos;'Vauban'&apos; in Freiburg was built with the goal to achieve CO2 -savings of 80% compared to todays standard new buildings regarding heating, warm water and electricity (incl. household appliances). The additional investment costs should not exceed 300 DM per square meter. Presentation of the working steps of the methods applied: Using the subsidies detailed solutions and calculations regarding rentability and costs could be obtained during the planning process. The cost-yield ratio (DM applied/saved primary energy) was determined for all measures planned.This instrument proved to be very useful in making decisions for selecting the measures to be taken. [German] Zielsetzung und Anlass des Vorhabens: Das Mehrfamilienhaus &apos;Wohnen and Arbeiten&apos; im Freiburger Konversionsgebiet &apos;Vauban&apos; entstand mit der Zielrichtung in den Bereichen Heizung, Warmwasser und Elektrizitaet (ink. Haushaltsgeraete) eine CO{sub 2}-Einsparung von 80% gegenueber dem heute ueblichen Neubaustandard zu erreichen. Dabei sollten die investiven Mehrkosten pro Quadratmeter Wohnflaeche nicht mehr als 300 DM betragen. Darstellung der Arbeitsschritte und der angewandten Methoden: Mit Hilfe der Foerdergelder konnten bereits waehrend des Planungsprozesses Detailloesungen, sowie ausfuehrliche Wirtschaftlichkeits- und Kostenbetrachtungen durchgefuehrt werden. Fuer alle geplanten Massnahmen wurde das Kosten-Nutzenverhaeltnis (eingesetzte DM/zu eingesparter Primaerenergie) bestimmt. Dieses Instrument hat sich als Entscheidungshilfe bei der Auswahl der Massnahmen ausserordentlich bewaehrt. (orig.)

  17. Tratamento endovascular de aneurismas cirsoideos do couro cabeludo Endovascular treatment of scalp cirsoid aneurysms

    Directory of Open Access Journals (Sweden)

    Eduardo Wajnberg

    2010-08-01

    Full Text Available OBJETIVO: Relatar os resultados da aplicação de técnicas endovasculares no tratamento de aneurismas cirsoideos do couro cabeludo. MATERIAIS E MÉTODOS: Quatro pacientes com diagnóstico de aneurismas cirsoideos foram submetidos ao tratamento por via endovascular. Todos os quatro pacientes incluídos nesta série tinham malformações arteriovenosas e foram tratados apenas com embolização. RESULTADOS: Três pacientes foram submetidos a tratamento endovascular mediante embolização transarterial e um foi tratado por punção direta da porção venosa. Os resultados clínicos e cosméticos foram satisfatórios em todos os pacientes. Não houve recidiva clínica durante o período de acompanhamento. CONCLUSÃO: A via endovascular é uma alternativa segura e eficaz no tratamento dos aneurismas cirsoideos. Embora possa ser efetivamente utilizado como uma alternativa adjuvante ou complementar à cirurgia, especialmente quando é necessário lidar com aferências profundas, a maioria dos casos pode ser totalmente curada apenas com a terapêutica endovascular. A escolha do método de tratamento deve ser baseada em uma variedade de características próprias da lesão, incluindo sua angioarquitetura, tamanho e apresentação clínica.OBJECTIVE: To report results of the application of endovascular techniques in the management of scalp cirsoid aneurysms. MATERIALS AND METHODS: Four patients diagnosed with cirsoid aneurysms were submitted to treatment by endovascular approach. All the four patients included in the present series had arteriovenous malformations and were treated solely by embolization. RESULTS: Three of the patients underwent endovascular treatment by transarterial embolization and one was treated by direct puncture of the venous segment. Both clinical and cosmetic outcomes were satisfactory in all of the patients. Clinical relapse was not observed along the follow-up period. CONCLUSION: The endovascular approach is safe and effective in

  18. Scientists from all over the world attend the &apos;&apos;Frederic Joliot/Otto Hahn Summer School 2009&apos;&apos; at the Karlsruhe Institute of Technology (KIT); Wissenschaftler aus aller Welt bei der &apos;&apos;Frederic Joliot/Otto Hahn Summer School 2009&apos;&apos; am Karlsruhe Institute of Technologie (KIT)

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Espinoza, Victor Hugo; Fischer, Ulrich [Karlsruhe Inst. of Tech. (KIT), Campus Nord/Inst. for Neutron Physics and Reactor Tech. (INR), Eggenstein-Leopoldshafen (Germany)

    2009-11-15

    The &apos;&apos;Frederic Joliot/Otto Hahn Summer School&apos;&apos; is organized each year alternately by the Karlsruhe Institute of Technology and the Commissariat a l&apos;Energie Atomique (CEA), Cadarache. This year&apos;s Summer School, the 15th since its foundation, was run at the Advanced Training Center (FTU) of KIT Campus Nord on August 26 to September 4. The key topic this year was &apos;&apos;The Challenges in Implementing Fast Reactor Technology.&apos;&apos; These are the items discussed: Principles and challenges of future fast reactor designs, Fuels, fuel cycle, and recycling of minor actinides, Innovative cladding tube and structural materials, Special aspects of coolants and the challenges they pose, Fast reactor safety. Experts from 8 leading international research establishments and universities presented and discussed with the 58 participants from 16 countries the current state of the art and the latest development trends in the topics listed above. (orig.)

  19. Photoluminescence of acupoint &apos;Waiqiu&apos; in human superficial fascia

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Yuan [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Yan Xiaohui [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Liu Chenglin [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China); Dang Ruishan [Second Military Medical University, Shanghai 200433 (China); Zhang Xinyi [Synchrotron Radiation Research Center, Department of Physics, Surface Physics Laboratory (State Key Laboratory) of Fudan University, Shanghai 200433 (China) and Shanghai Research Center of Acupuncture and Meridian, Pudong, Shanghai 201203 (China)]. E-mail: xy-zhang@fudan.edu.cn

    2006-07-15

    The spectral characters of an acupuncture point named &apos;Waiqiu&apos; in superficial fascia tissue have been studied by photoluminescence (PL) spectroscopy under the excitation of 457.9 nm. The PL around &apos;Waiqiu&apos; acupuncture point consists of two sub-bands resulting from the flavin adenine dinucleotide (FAD) and phospholipids, and the porphyrins (including purine, isoxanthopterin and tryptophan), respectively. More emission due to FAD and phospholipids is found inside the acupuncture effect area of &apos;Waiqiu&apos; than its marginal or outside acupuncture regions. The ratio of emission intensity of FAD and phospholipids to one of porphyrins gradually decreases along the direction away from the center of the acupuncture point. It implies that the component proportion changes between FAD, phospholipids and porphyrins around the &apos;Waiqiu&apos; acupuncture point. We suggest that there might be a certain relationship between redox function of FAD and &apos;Waiqiu&apos; acupuncture effect.

  20. &apos;Minergie&apos; modernisation - Test in practice; Praxistest Minergie-Modernisierung

    Energy Technology Data Exchange (ETDEWEB)

    Ruetter, H.; Ruetter-Fischbacher, U. [Ruetter und Partner, Soziooekonomische Forschung und Beratung, Rueschlikon (Switzerland); Haessig, W. [Haessig Sustech GmbH - Ingenieurbuero fuer Minergie und nachhaltige Gebaeudetechnik, Uster (Switzerland); Jakob, M. [TEP Energy GmbH, CEPE ETH, Zuerich (Switzerland)

    2008-07-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) examines the results obtained in practice concerning the use of the &apos;Minergie&apos; low energy consumption standard. Experience gained with &apos;Minergie&apos; refurbishment projects is reviewed and the critical points and constraints found are discussed. Further, recommendations for improvements in the use of the &apos;Minergie&apos; standard are made. The study is based on questions posed to building owners in the German speaking part of Switzerland who have carried out refurbishment projects to meet &apos;Minergie&apos; standards as well as questions posed to those who did not adhere to &apos;Minergie&apos; standards in the refurbishment of their buildings. The reasons quoted for using / not using the standard are listed and discussed. Possible tightening of energy regulations concerning renovation work are discussed. The recommendations resulting from the survey are also noted and discussed.

  1. Behavioral phenotype and BDNF differences related to apoE isoforms and sex in young transgenic mice

    DEFF Research Database (Denmark)

    Reverte, Ingrid; Klein, Anders Bue; Ratner, Cecilia;

    2012-01-01

    , very little information is available on apoE2 genotype. In the present study, we have characterized behavioral and learning phenotypes in young transgenic mice apoE2, apoE3 and apoE4 of both sexes. We have also determined the levels of brain-derived neurotrophic factor (BDNF) and its receptor Trk...... in the exploration of an open-field, which is compatible with a hyperactive behavior, was found in apoE2 females, while a decreased activity was observed in apoE4 mice. Increased BDNF levels in the frontal cortex were observed in apoE2 mice compared to apoE3. These results underscore behavioral differences between...

  2. Diretrizes brasileiras para o tratamento da narcolepsia Brazilian guidelines for the treatment of narcolepsy

    Directory of Open Access Journals (Sweden)

    Flávio Alóe

    2010-09-01

    Full Text Available Este artigo relata as conclusões da reunião de consenso da Associação Brasileira de Sono com médicos especialistas brasileiros sobre o tratamento da narcolepsia, baseado na revisão dos artigos sobre narcolepsia publicados entre 1980 e 2010. Os objetivos do consenso são valorizar o uso de agentes avaliados em estudos randomizados placebo-controlados, emitir recomendações de consenso para o uso de outras medicações e informar pontos importantes a respeito da segurança e efeitos adversos das medicações. O tratamento da narcolepsia é baseado em diversas classes de agentes, estimulantes para sonolência excessiva, agentes antidepressivos para cataplexia e hipnóticos para sono noturno fragmentado. Medidas comportamentais são igualmente importantes e recomendadas universalmente. Todos os ensaios clínicos terapêuticos foram classificados de acordo com o nível de qualidade da evidência. Recomendações terapêuticas individualizadas para cada tipo de sintoma e recomendações gerais foram formuladas pelos autores. Modafinila é indicada como a primeira escolha para o tratamento da sonolência diurna. Agentes de segunda escolha para o tratamento da sonolência excessiva são metilfenidato de liberação lenta seguido pelo mazindol. Reboxetina, clomipramina, venlafaxina, desvenlafaxina e os inibidores seletivos de recaptação de serotonina em doses altas são a primeira escolha para o tratamento da cataplexia. Hipnóticos são utilizados para o tratamento do sono noturno fragmentado. Antidepressivos e hipnóticos são igualmente utilizados para o tratamento das alucinações hipnagógicas e paralisia do sono.This manuscript contains the conclusion of the consensus meeting of the Brazilian Sleep Association with Brazilian sleep specialists on the treatment of narcolepsy based on the review of medical literature from 1980 to 2010. The manuscript objectives were to reinforce the use of agents evaluated in randomized placebo

  3. Evaluatie onderzoeksprogramma&apos;s milieutechnologie vanuit een invalshoek stoffen

    NARCIS (Netherlands)

    Lijzen JPA

    1991-01-01

    This study was carried out to determine the need of a separate programme of the &apos;Regulation for the Advancement of Environmental Technology&apos; (&apos;Sti-MT&apos;) to stimulate technology from a substance point of view. Therefore 6 programms of the &apos;Sti-MT&apos; and 5 other technologic

  4. Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study.

    Directory of Open Access Journals (Sweden)

    Laurence O'Dwyer

    Full Text Available The E4 allele of the ApoE gene has consistently been shown to be related to an increased risk of Alzheimer's disease (AD. The E4 allele is also associated with functional and structural grey matter (GM changes in healthy young, middle-aged and older subjects. Here, we assess volumes of deep grey matter structures of 22 healthy younger ApoE4 carriers and 22 non-carriers (20-38 years. Volumes of the nucleus accumbens, amygdala, caudate nucleus, hippocampus, pallidum, putamen, thalamus and brain stem were calculated by FMRIB's Integrated Registration and Segmentation Tool (FIRST algorithm. A significant drop in volume was found in the right hippocampus of ApoE4 carriers (ApoE4+ relative to non-carriers (ApoE4-, while there was a borderline significant decrease in the volume of the left hippocampus of ApoE4 carriers. The volumes of no other structures were found to be significantly affected by genotype. Atrophy has been found to be a sensitive marker of neurodegenerative changes, and our results show that within a healthy young population, the presence of the ApoE4+ carrier gene leads to volume reduction in a structure that is vitally important for memory formation. Our results suggest that the hippocampus may be particularly vulnerable to further degeneration in ApoE4 carriers as they enter middle and old age. Although volume reductions were noted bilaterally in the hippocampus, atrophy was more pronounced in the right hippocampus. This finding relates to previous work which has noted a compensatory increase in right hemisphere activity in ApoE4 carriers in response to preclinical declines in memory function. Possession of the ApoE4 allele may lead to greater predilection for right hemisphere atrophy even in healthy young subjects in their twenties.

  5. Environmental education project &apos;Mico-Estrela Track&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Vicente, Ana Paula Camargo de; Magalhaes, Milton Pinto Magalhaes; Silva, Simone Rodrigues da; Pinheiro, Roberta Vieira Nunes; Torres, Carlos Alberto Rodrigues; Silveira, Jeanete [PETROBRAS Transporte S.A. (TRANSPETRO), Rio de Janeiro, RJ (Brazil)

    2009-12-19

    Senador Canedo fuel storage terminal is situated in the Cerrado biome and implements the policy of promoting improvements in the preservation of its Green Belt by working out the Environmental Education Project &apos;Mico-Estrela7 Track&apos;, aimed at stimulating the preservation, protection, landscape beauty and defense of scientific sources of the Cerrado through environmental sensibilization and rational use of the existing natural resources. In the area of the track (1.5 ha) alone 352 plants have been identified, totaling 97 different species that are distributed in 36 families. The implementation of the project will contribute to strengthen the relations with the local community, like dwellers, teachers and pupils of the municipal network of Senador Canedo, as well as co-workers of the unit, thus reaffirming the commitment of the company to socio-environmental responsibility. (author)

  6. Chronic radiation effects on dental hard tissue (&apos;&apos;radiation carries&apos;&apos;). Classification and therapeutic strategies; Chronische Strahlenfolgen an den Zahnhartgeweben (&apos;'Strahlenkaries'&apos;). Klassifikation und Behandlungsansaetze

    Energy Technology Data Exchange (ETDEWEB)

    Groetz, K.A.; Brahm, R.; Al-Nawas, B.; Wagner, W. [Universitaetsklinik und Poliklinik fuer Mund-, Kiefer- und Gesichtschirurgie, Mainz (Germany); Riesenbeck, D.; Willich, N. [Universitaetsklinik und Poliklinik fuer Strahlentherapie -Radioonkologie, Muenster (Germany); Seegenschmiedt, M.H. [Alfried-Krupp-Krankenhaus Essen (Germany). Klinik und Poliklinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Doerr, W. [Technische Univ. Dresden (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie; Kutzner, J.; Thelen, M. [Universitaetsklinik und Poliklinik fuer Radiologie/Strahlentherapie, Mainz (Germany)

    2001-02-01

    Objectives: Since the first description of rapid destruction of dental hard tissues following head and neck radiotherapy 80 years ago, &apos;radiation caries&apos; is an established clinical finding. The internationally accepted clinical evaluation score RTOG/EORTC however is lacking a classification of this frequent radiogenic alteration. Material and Methods: Medical records, data and images of radiation effects on the teeth of more than 1,500 patients, who underwent periradiotherapeutic care, were analyzed. Macroscopic alterations regarding the grade of late lesions of tooth crowns were used for a classification into 4 grades according to the RTOG/EORTC guidelines. Results: No early radiation effects were found by macroscopic inspection. In the first 90 days following radiotherapy 1/3 of the patients complained of reversible hypersensitivity, which may be related to a temporary hyperemia of the pulp. It was possible to classify radiation caries as a late radiation effect on a graded scale as known from RTOG/EORTC for other organ systems. This is a prerequisite for the integration of radiation caries into the international nomenclature of the RTOG/EORTC classification. Conclusions: The documentation of early radiation effects on dental hard tissues seems to be neglectable. On the other hand the documentation of late radiation effects has a high clinical impact. The identification of an initial lesion at the high-risk areas of the neck and incisal part of the tooth can lead to a successful therapy as a major prerequisite for orofacial rehabilitation. An internationally standardized documentation is a basis for the evaluation of the side effects of radiooncotic therapy as well as the effectiveness of protective and supportive procedures. (orig.) [German] Fragestellung: Die rasche Zahnhartgewebszerstoerung nach einer Kopf-Hals-Bestrahlung wurde bereits vor fast 80 Jahren als &apos;Strahlenkaries&apos; beschrieben und ist seither als klinischer Befund in der Routine

  7. A cool &apos;win-win&apos; for Matra

    Energy Technology Data Exchange (ETDEWEB)

    Wolff, V. [Alstom, Budapest (Hungary)

    2007-07-15

    In 2004 the Matra plant management initiated a 60 M euro investment programme to increase the generating capacity of units 4 and 5 of the lignite fuelled plant and to give it greater flexibility. This has been achieved by adding a 30 MW natural gas-fired topping gas turbine to each of the 230 MW units, for commissioning by 2007. The power uprate meant the capacity of the dry-tower based cooling system was increased by 24 W for each unit. This has now undergone a major upgrade, involving addition of a wet cooling tower to create a &apos;hybrid&apos; system. It is one of the largest such projects ever carried out, and the first involving a dry-tower cooling system of the Heller type. The result is increased competitiveness and efficiency, with a 250,000 t reduction in annual carbon dioxide emissions. 3 figs.

  8. 7. Duesseldorf Energy Law Conference &apos;&apos;Grid Access Regulation - Preliminary Evaluation&apos;&apos;; 7. Duesseldorfer Energierechtstag &apos;&apos;Netzregulierung - Ein erstes Fazit&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Buedenbender, U. [Technische Univ. Dresden (Germany). Lehrstuhl fuer Buergerliches Recht, Energiewirtschaft und Arbeitsrecht; Rosin, P. [Clifford Chance, Duesseldorf (Germany); Schmidt, M.F. (eds.)

    2007-07-01

    This book contains the papers presented at the 7th Duesseldorf energy law conference on grid access regulation, in which renowned experts of the Bundesnetzagentur, science and industry take stock for the first time of grid access regulation and its effects on the power industry. The focus of the papers is on current court rulings which are viewed from different angles. The issues are discussed both from the view of legal science and from the view of the courts and the parties concerned. The &apos;pilot case&apos; of Vattenfall Europe Transmission GmbH vs. Bundesnetzagentur gets particular attention. A report on the experience with regulation management shows how legal specifications are reflected in the everyday work of grid operators. (orig.)

  9. Putting &apos;international&apos; back in IPEC.

    Energy Technology Data Exchange (ETDEWEB)

    Veil, J. A.

    2000-10-27

    During the previous six annual sessions of the International Petroleum Environmental Conference (IPEC), little attention has been given to international issues. Although the US is clearly a leader in oil field research and regulatory development information is available on interesting projects throughout the world Many participants in IPEC have little exposure to international oil and gas environmental problems and solutions. Beginning with the 7th IPEC, a stronger effort is being made to include international issues in the confidence. This paper describes some of the author&apos;s experiences in working with international oil and gas environmental issues in North America, Latin America, Europe, and Asia. Among the topics to be discussed are the issues that developing oil and gas-producing nations face and the need for sensitivity to other nation&apos;s cultures and legal systems.

  10. Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.

    Science.gov (United States)

    Biundo, Fabrizio; Ishiwari, Keita; Del Prete, Dolores; D'Adamio, Luciano

    2015-12-01

    Mutations in Amyloid β Precursor Protein (APP) and in genes that regulate APP processing--such as PSEN1/2 and ITM2b/BRI2--cause familial dementia, such Familial Alzheimer disease (FAD), Familial Danish (FDD) and British (FBD) dementias. The ApoE gene is the major genetic risk factor for sporadic AD. Three major variants of ApoE exist in humans (ApoE2, ApoE3, and ApoE4), with the ApoE4 allele being strongly associated with AD. ITM2b/BRI2 is also a candidate regulatory node genes predicted to mediate the common patterns of gene expression shared by healthy ApoE4 carriers and late-onset AD patients not carrying ApoE4. This evidence provides a direct link between ITM2b/BRI2 and ApoE4. To test whether ApoE4 and pathogenic ITM2b/BRI2 interact to modulate learning and memory, we crossed a mouse carrying the ITM2b/BRI2 mutations that causes FDD knocked-in the endogenous mouse Itm2b/Bri2 gene (FDDKI mice) with human ApoE3 and ApoE4 targeted replacement mice. The resultant ApoE3, FDDKI/ApoE3, ApoE4, FDDKI/ApoE4 male mice were assessed longitudinally for learning and memory at 4, 6, 12, and 16-17 months of age. The results showed that ApoE4-carrying mice displayed spatial working/short-term memory deficits relative to ApoE3-carrying mice starting in early middle age, while long-term spatial memory of ApoE4 mice was not adversely affected even at 16-17 months, and that the FDD mutation impaired working/short-term spatial memory in ApoE3-carrying mice and produced impaired long-term spatial memory in ApoE4-carrying mice in middle age. The present results suggest that the FDD mutation may differentially affect learning and memory in ApoE4 carriers and non-carriers.

  11. QUALIDADE DE GOIABAS ‘PEDRO SATO’ EM FUNÇÃO DE TRATAMENTOS ALTERNATIVOS EM PÓS-COLHEITA

    Directory of Open Access Journals (Sweden)

    MARIA CECÍLIA DE ARRUDA PALHARINI

    2016-02-01

    Full Text Available RESUMO Este trabalho teve como objetivo avaliar o efeito de produtos alternativos e termoterapia, isoladamente e em associação, na qualidade físico-química e no controle das podridões de goiabas ‘Pedro Sato’. Inicialmente, foi avaliado o efeito dos tratamentos em pós-colheita com cloreto de cálcio, fosfito de potássio, 1-metilciclopropeno (1-MCP, fécula de mandioca, etanol seguido de cloro (etanol+cloro e termoterapia, durante oito dias de armazenamento dos frutos a 22ºC. Em uma segunda etapa, quatro tratamentos foram selecionados (fécula de mandioca, 1-MCP, termoterapia e etanol+cloro e avaliados em associação de dois, aplicados de forma sequencial, durante oito dias de armazenamento dos frutos a 25ºC. Os tratamentos 1-MCP e fécula foram os mais eficazes em manter a qualidade físico-química das goiabas ‘Pedro Sato’, retardando a perda de massa, a mudança de coloração da casca e contribuindo para a retenção da firmeza. Constatou-se maior redução de frutos com podridão nos tratamentos com termoterapia, fécula de mandioca e 1-MCP. As associações de tratamento com 1-MCP/fécula de mandioca e termoterapia/fécula foram os tratamentos mais eficazes em manter a qualidade das goiabas ‘Pedro Sato’, retardando a perda de massa, a mudança de coloração da casca e a redução da firmeza. As associações de tratamento reduziram a ocorrência de podridões, com destaque para os tratamentos com etanol+cloro/termoterapia e termoterapia/fécula, que foram mais eficientes até o quarto dia de armazenamento. Observou-se correlação entre a incidência de podridões e os parâmetros cor da casca e firmeza da polpa para a maioria das associações de tratamentos. De maneira geral, recomenda-se o tratamento com termoterapia/fécula para goiabas armazenadas a 22-25ºC, como forma de manutenção da qualidade físico-química e atrasando em, pelo menos, dois dias os sintomas de podridões.

  12. Functional and morphological parameters with tissue characterization of cardiovascular magnetic imaging in clinically verified &apos;&apos;infarct-like myocarditis&apos;&apos;

    International Nuclear Information System (INIS)

    Cardiac magnetic resonance (CMR) has increasingly proved to be a valuable diagnostic tool for evaluating patients with suspected myocarditis. The objective of this study was to evaluate the diagnostic value of functional and morphological parameters including tissue characterization in patients with &apos;&apos;infarct-like myocarditis&apos;&apos;. 43 patients with clinically verified cases of &apos;&apos;infarct-like myocarditis&apos;&apos; (median time to MRI scanning after admission for acute symptoms 3 days) and 35 control patients matched by age and sex were included in this retrospective case control study. In this study we used a 1.5 T MRI scanner conducting steady-state-free-precession sequences, T2-weighted imaging, T1-weighted imaging before and after contrast administration and late gadolinium enhancement sequences. According to the recommendations for CMR diagnosis of myocarditis (Lake Louise consensus criteria), a scan was positive for acute myocarditis if 2 of 3 CMR criteria were present. 30 % of the patients with &apos;&apos;infarct-like myocarditis&apos;&apos; had a reduced left ventricular ejection fraction, 11 % had an increased LV end-diastolic volume index and 35 % had an increased LV mass index. The sensitivity of wall motion abnormalities was 63 % with a regional distribution in 49 %. In 47 % of cases regional wall motion abnormalities were present in the lateral left ventricular segments. Pericardial effusions were discovered in 65 % of cases with a circular appearance in 21 % and focal manifestation in 44 %. The diagnostic sensitivity, specificity, and accuracy of CMR in patients with &apos;&apos;infarct-like myocarditis&apos;&apos; were 67 %, 100 % and 82 %, respectively. The LGE alone was the most sensitive test parameter with 86 %, providing a specificity of 100 % and accuracy of 92 %. Our study results can be applied to the subgroup of patients with &apos;&apos;infarct-like myocarditis&apos;&apos;, where we found that LGE alone was the

  13. Functional and morphological parameters with tissue characterization of cardiovascular magnetic imaging in clinically verified &apos;&apos;infarct-like myocarditis&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Schwab, Johannes [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Radiology; Rogg, H.J.; Pauschinger, M.; Fessele, K. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology; Bareiter, T.; Baer, I. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Cardiology and Neuroradiology; Loose, R. [Paracelsus Medical Univ., General Hospital Nuremberg (Germany). Dept. of Radiology

    2016-04-15

    Cardiac magnetic resonance (CMR) has increasingly proved to be a valuable diagnostic tool for evaluating patients with suspected myocarditis. The objective of this study was to evaluate the diagnostic value of functional and morphological parameters including tissue characterization in patients with &apos;&apos;infarct-like myocarditis&apos;&apos;. 43 patients with clinically verified cases of &apos;&apos;infarct-like myocarditis&apos;&apos; (median time to MRI scanning after admission for acute symptoms 3 days) and 35 control patients matched by age and sex were included in this retrospective case control study. In this study we used a 1.5 T MRI scanner conducting steady-state-free-precession sequences, T2-weighted imaging, T1-weighted imaging before and after contrast administration and late gadolinium enhancement sequences. According to the recommendations for CMR diagnosis of myocarditis (Lake Louise consensus criteria), a scan was positive for acute myocarditis if 2 of 3 CMR criteria were present. 30 % of the patients with &apos;&apos;infarct-like myocarditis&apos;&apos; had a reduced left ventricular ejection fraction, 11 % had an increased LV end-diastolic volume index and 35 % had an increased LV mass index. The sensitivity of wall motion abnormalities was 63 % with a regional distribution in 49 %. In 47 % of cases regional wall motion abnormalities were present in the lateral left ventricular segments. Pericardial effusions were discovered in 65 % of cases with a circular appearance in 21 % and focal manifestation in 44 %. The diagnostic sensitivity, specificity, and accuracy of CMR in patients with &apos;&apos;infarct-like myocarditis&apos;&apos; were 67 %, 100 % and 82 %, respectively. The LGE alone was the most sensitive test parameter with 86 %, providing a specificity of 100 % and accuracy of 92 %. Our study results can be applied to the subgroup of patients with &apos;&apos;infarct-like myocarditis&apos;&apos;, where we found that LGE alone was the

  14. Solar students&apos; hostel at Kaiserslautern

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, W.; Vangerow-Kuehn, A.

    A students&apos; hostel including 30 living units is being built at the University of Kaiserslautern. Together with the department of biology the students of the department of architecture, regional and environmental planning, civil engineering, are planning an &apos;'alternative'&apos; hostel. It is to be constructed on the university campus in self-construction. The passive utilization of solar energy for the conservation of heating costs is focused in the design planning. The hostel shall be roofed with a standard, low-priced greenhouse construction of a prefabrication degree of 100% and including standardized ventilation devices and blinds.

  15. From Higgs to quantum gravity. New particles, exotic numbers, and the &apos;&apos;theory for all&apos;&apos;; Vom Higgs zur Quantengravitation. Neue Teilchen, exotische Zahlen und die &apos;&apos;Theorie fuer alles&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Koenneker, Carsten (comp.)

    2013-11-01

    The following topics are dealt with: The hunting for the quark-gluon plasma, the long way to the Higgs, the LHC after the Higgs, life in the quantum world, Schroedinger&apos;s cat on the test, on the way to quantum gravity, with a computational trick to the comprehensive theory of natural forces, antirealistic maverick, exotic numbers and string theory, physics as a ramshackle tower of Babel. (HSI)

  16. Finishing report for the &apos;SolcelleInverter&apos; project

    Energy Technology Data Exchange (ETDEWEB)

    Boekhoej Kjaer, S.

    2005-03-01

    The main objective for this research project was to develop an inverter for the AC module, where one PV module is equipped with its own dedicated inverter, and connected to the grid. A topology, among many different candidates, has been selected, based on analysis&apos;s. The inverter has been optimized in respect to cost, reliability, and efficiency, and a prototype has been build. (au)

  17. Endovascular treatment of aortic arch aneurysms Tratamento endovascular dos aneurismas de arco aórtico

    Directory of Open Access Journals (Sweden)

    Roberto Chiesa

    2008-06-01

    Full Text Available BACKGROUND: Endovascular approach to the aortic arch is an appealing solution for selected patients. OBJECTIVE: To compare the technical and clinical success recorded in the different anatomical settings of endografting for aortic arch disease. METHODS: Between June 1999 and October 2006, among 178 patients treated at our institution for thoracic aorta disease with a stent-graft, the aortic arch was involved in 64 cases. According to the classification proposed by Ishimaru, aortic zone 0 was involved in 14 cases, zone 1 in 12 cases and zone 2 in 38 cases. A hybrid surgical procedure of supra-aortic debranching and revascularization was performed in 37 cases. RESULTS: Zone 0. Proximal neck length: 44±6 mm. Initial clinical success was 78.6%: two deaths (stroke, one type Ia endoleak. At a mean follow-up of 16.4±11 months the midterm clinical success was 85.7%. Zone 1. Proximal neck length: 28±5 mm. Initial clinical success was 66.7%: 0 deaths, four type Ia endoleaks. At a mean follow-up of 16.9±17.2 months the midterm clinical success was 75.0%. Zone 2. Proximal neck length: 30±5 mm. Initial clinical success was 84.2%: two deaths (one cardiac arrest, one multiorgan embolization, three type Ia endoleaks, one case of open conversion. Two cases of delayed transitory paraparesis/paraplegia were observed. At a mean follow-up of 28.0±17.2 months the midterm clinical success was 89.5%. CONCLUSIONS: This study and a literature review demonstrated that hybrid procedure for aortic arch pathology is feasible in selected patients at high risk for conventional surgery. Our experience is still limited by the relatively small sample size. We propose to reserve zone 1 for patients unfit for sternotomy or in cases with aortic neck length > 30 mm following left common carotid artery debranching. We recommend to perform complete aortic rerouting of the aortic arch in cases with lesser comorbidities and shorter aortic neck.CONTEXTO: O tratamento endovascular

  18. The location selection act or &apos;the Emperor&apos;s new clothes&apos;; Das Standortauswahlgesetz oder &apos;Des Kaisers neue Kleider&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Feldmann, Ulrike

    2013-10-15

    As is generally known, the governing parties CDU/CSU and FDP agreed a few weeks ago in the 17{sup th} legislative period of the German Bundestag in a rare show of unanimity, together with the parties SPD and Buendnis 90/Die Gruenen, as well as with the Laender, on a &apos;law to search and select a location for a permanent disposal site for heat-generating radioactive waste products and to change other laws&apos;, in brief a location selection act also called StandAG. The law was received with animated approval from the ranks of the parties - with the exception of the (left-wing) party Die Linke. This praise is a tad bewildering, since the Bundesumweltministerium (Federal Department of the Environment) named solving the task within a single generation as one of the principles for the StandAG, and it was emphasised again and again in the debates about the StandAG that the problem of permanent disposal must not be shifted to the next generation. Conclusion: - The StandAG leads to a postponement of solving the permanent disposal site issue by a least several generations with its predictable, long-winded selection method. - The decision not to explore Gorleben conclusively could lead to the site being permanently (&apos;wasted&apos; or) &apos;burned&apos;. - The de-central, interim disposal site Gorleben is likewise &apos;burned&apos; without having a resilient alternative solution for the glass coquilles that must be taken back. - The people&apos;s protest is exponentiated by the number of the potential sites for the StandAG. - The costs for the alternative site search will not be shifted to the producers of the waste that are obliged by law to deliver the waste because of the financial provisions of the constitution. - The third party protection dogma has not been broken up, which will at least lead to delays in the procedure and will have effects on other major projects in the long run. (orig.)

  19. Einstein&apos;s quest for unification

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, John [Theory Division at CERN, Geneva (Switzerland)

    2005-01-01

    The last 30 years of his life were spent on a fruitless search for a unified field theory, but as John Ellis explains, Einstein put this &apos;holy grail&apos; of modern physics on the theoretical map. The definitive scientific biography of Einstein, Subtle is the Lord..., which was written by Abraham Pais in 1982, delivered an unequivocal verdict on Einstein&apos;s quest for a unified field theory. Pais wrote that the time for unification had not come, and that Einstein&apos;s work &apos;led to no results of physical interest&apos;. But a lot of water has flowed under the bridge of unification since then, allowing us to look back with perhaps more indulgence as we celebrate the centenary of Einstein&apos;s 1905 papers. (U.K.)

  20. Doença periapical em eqüinos: estudo de quatro casos Periapical disease in equine: study of four cases

    Directory of Open Access Journals (Sweden)

    G.M. Pagliosa

    2004-02-01

    Full Text Available Estudaram-se quatro casos de doença periapical (DP em eqüinos submetidos à apicectomia e extração dentária. O diagnóstico baseou-se na anamnese, nos exames físico geral e oral e na radiologia. A apicectomia foi ineficaz devido à falta de tratamento endodôntico e a extração dentária mostrou-se a melhor conduta de tratamento, apesar da dificuldade de cura completa da infecção. A DP pode ter causas adicionais a serem definidas, além das classificadas como primária e secundária pela literatura.Four cases of periapical disease (PC in equines submitted to apicoectomy and dental extraction were studied. The diagnosis was based on anamnesis, physical and oral examination and radiology. The apicoectomy was not effective due of the lack of endodontic treatment. The dental extraction was the better treatment, despite of the difficulty of complete cure of the infection. The PC can have other causes, beyond of those classified as primary and secondary by the literature.

  1. Mothers&apos; Beliefs about Children&apos;s Learning in Hong Kong and the United States: Implications for Mothers&apos; Child-Based Worth

    Science.gov (United States)

    Ng, Florrie Fei-Yin; Pomerantz, Eva M.; Lam, Shui-fong

    2013-01-01

    Chinese and American mothers&apos; beliefs about children&apos;s learning and parents&apos; role in it were examined using notions salient in Chinese culture. Mothers from Hong Kong ("n" = 66) and the United States ("n" = 69) indicated their endorsement of the ideas that children&apos;s learning reflects children&apos;s…

  2. The intern structure of special relativity; La &apos;&apos;structure fine&apos;&apos; de la relativite restreinte

    Energy Technology Data Exchange (ETDEWEB)

    Pierseaux, Y. [Universite Libre de Bruxelles (Belgium)

    1999-07-01

    The author presents the forgotten fact that in 1905 there were 2 restricted theories of relativity: that of Einstein and that of Poincare. These 2 theories were independently formulated, they are very close to each other but are fundamentally different when we consider their basic principles. Poincare&apos;s theory is based on a classical representation of the purely undulatory aspect of light, whereas Einstein stipulates for the quantum aspect of light. Poincare&apos;s theory implies the existence of the ether and asserts the primacy of continuity over discontinuity. The author has based his work on a thorough study of the scientific articles in which Poincare and Einstein explained their ideas. The comparison of these 2 theories sheds light on the evolution of concepts on which the whole modern physics is based. An extended bibliography of works published on special relativity or on related topics is given. (A.C.)

  3. CT angiography helps to differentiate acute from chronic carotid occlusion: the &apos;&apos;carotid ring sign&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Michel, Patrik; Ntaios, George [Centre Hospitalier Universitaire Vaudois and University of Lausanne, Neurology Service, Lausanne (Switzerland); Delgado, Montserrat G. [Hospital Universitario Central de Asturias, Oviedo (Spain); Bezerra, Daniel C. [Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, Baltimore, MD (United States); Meuli, Reto; Binaghi, Stefano [Centre Hospitalier Universitaire Vaudois and University of Lausanne, Department of Radiology, Lausanne (Switzerland)

    2012-02-15

    Currently, there is no reliable method to differentiate acute from chronic carotid occlusion. We propose a novel CTA-based method to differentiate acute from chronic carotid occlusions that could potentially aid clinical management of patients. We examined 72 patients with 89 spontaneously occluded extracranial internal carotids with CT angiography (CTA). All occlusions were confirmed by another imaging modality and classified as acute (imaging <1 week of presumed occlusion) orchronic (imaging >4 weeks), based on circumstantial clinical and radiological evidence. A neuroradiologist and a neurologist blinded to clinical information determined the site of occlusion on axial sections of CTA. They also looked for (a) hypodensity in the carotid artery (thrombus), (b) contrast within the carotid wall (vasa vasorum), (c) the site of the occluded carotid, and (d) the &apos;&apos;carotid ring sign&apos;&apos; (defined as presence of a and/or b). Of 89 occluded carotids, 24 were excluded because of insufficient circumstantial evidence to determine timing of occlusion, 4 because of insufficient image quality, and 3 because of subacute timing of occlusion. Among the remaining 45 acute and 13 chronic occlusions, inter-rater agreement (kappa) for the site of proximal occlusion was 0.88, 0.45 for distal occlusion, 0.78 for luminal hypodensity, 0.82 for wall contrast, and 0.90 for carotid ring sign. The carotid ring sign had 88.9% sensitivity, 69.2% specificity, and 84.5% accuracy to diagnose acute occlusion. The carotid ring sign helps to differentiate acute from chronic carotid occlusion. If further confirmed, this information may be helpful in studying ischemic symptoms and selecting treatment strategies in patients with carotid occlusions. (orig.)

  4. Development of new VOC exposure metrics and their relationship to &apos;&apos;Sick Building Syndrome&apos;&apos; symptoms

    Energy Technology Data Exchange (ETDEWEB)

    None

    1995-08-01

    Volatile organic compounds (VOCs) are suspected to contribute significantly to &apos;&apos;Sick Building Syndrome&apos;&apos; (SBS), a complex of subchronic symptoms that occurs during and in general decreases away from occupancy of the building in question. A new approach takes into account individual VOC potencies, as well as the highly correlated nature of the complex VOC mixtures found indoors. The new VOC metrics are statistically significant predictors of symptom outcomes from the California Healthy Buildings Study data. Multivariate logistic regression analyses were used to test the hypothesis that a summary measure of the VOC mixture, other risk factors, and covariates for each worker will lead to better prediction of symptom outcome. VOC metrics based on animal irritancy measures and principal component analysis had the most influence in the prediction of eye, dermal, and nasal symptoms. After adjustment, a water-based paints and solvents source was found to be associated with dermal and eye irritation. The more typical VOC exposure metrics used in prior analyses were not useful in symptom prediction in the adjusted model (total VOC (TVOC), or sum of individually identified VOCs ({Sigma}VOC{sub i})). Also not useful were three other VOC metrics that took into account potency, but did not adjust for the highly correlated nature of the data set, or the presence of VOCs that were not measured. High TVOC values (2--7 mg m{sup {minus}3}) due to the presence of liquid-process photocopiers observed in several study spaces significantly influenced symptoms. Analyses without the high TVOC values reduced, but did not eliminate the ability of the VOC exposure metric based on irritancy and principal component analysis to explain symptom outcome.

  5. Depositional &apos;'cyclicity'&apos; on carbonate platforms: Real-world limits on computer-model output

    Energy Technology Data Exchange (ETDEWEB)

    Boss, S.K.; Neumann, A.C. (Univ. of North Carolina, Chapel Hill, NC (United States)); Rasmussen, K.A. (Northern Virginia Community Coll., Annandale, VA (United States))

    1994-03-01

    Computer-models which attempt to define interactions among dynamic parameters believed to influence the development of &apos;'cyclic'&apos; carbonate platform sequences have been popularized over the past few years. These models typically utilize vectors for subsidence (constant) and cyclical (sinusoidal) eustatic sea-level to create accommodation space which is filled by sedimentation (depth-dependent rates) following an appropriate lag time (non-depositional episode during initial platform flooding). Since these models are intended to reflect general principles of cyclic carbonate deposition, it is instructive to test their predictive utility by comparing typical model outputs with an actively evolving depositional cycle on a modern carbonate platform where rates of subsidence, eustatic sea-level and sediment accumulation are known. Holocene carbonate deposits across northern Great Bahama Bank provide such an ideal test-platform for model-data comparisons. On Great Bahama Bank, formation of accommodation space depends on eustatic sea-level rise because tectonic subsidence is very slow. Contrary to typical model input parameters, however, the rate of formation of accommodation space varies irregularly across the bank-top because irregular bank-top topography (produced by subaerial erosion and karstification) results in differential flooding of the platform surface. Results of this comparison indicate that typical computer-model input variables (subsidence, sea-level, sedimentation, lag-time) and output depositional geometries are poorly correlated with real depositional patterns across Great Bahama Bank. Since other modern carbonate platforms and ancient carbonate sequences display similarly complex stratigraphies, it is suggested that present computer-modeling results have little predictive value for stratigraphic interpretation.

  6. IPSN activity report 1999; Rapport d&apos;activite de l&apos;IPSN 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    The &apos;&apos;Institut de Protection et de Surete Nucleaire&apos;&apos; (IPSN), carries out researches and expert studies needed to manage nuclear risks and their consequences on people and environment. These activities cover the installation safety, the radioactive matter transport, the public health and environmental control, the nuclear matters safety and control and the crisis situation management. The IPSN have got also a mission of public information and participates to international actions in the domain of scientific researches or expert&apos;s report. This annual report presents the highlights of the year 1999, information on staff, budgets and geographical situation. Then technical and scientific papers gathers the activities of the year covered by the IPSN: the &apos;&apos;Free Tribune&apos;&apos;, installations and radioactive wastes safety, crisis and nuclear matter management, public health and environment control, international cooperation. (A.L.B.)

  7. Scenarios for an integrated sustainability policy - using the example of the &apos;&apos;Sustainable City 2030&apos;&apos;. Vol. 2; Szenarien fuer eine integrierte Nachhaltigkeitspolitik - am Beispiel: Die nachhaltige Stadt 2030. Bd. 2. Teilbericht &apos;&apos;Kreislaufstadt 2030&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Verbuecheln, Maic; Grabow, Busso; Uttke, Angela; Schwausch, Mandy [Deutsches Inst. fuer Urbanistik (DiFu), Berlin (Germany); Gassner, Robert [Institut fuer Zukunftsstudien und Technologiebewertung gGmbH (IZT), Berlin (Germany)

    2013-04-15

    The partial report &apos;&apos;Recycling City 2030&apos;&apos; was prepared for the Federal Environment Agency (Dessau, Federal Republic of Germany) as a part of the project &apos;&apos;Scenarios for an integrated sustainability policy - the example of &apos;The Sustainable City 2030 &apos;'&apos;. This partial report is based on research activities of the German Institute of Urban Affairs (Berlin, Federal Republic of Germany) and Institute for Futures Studies and Technology Assessment (Berlin, Federal Republic of Germany). The objectives of this partial report are: (1) Description of the challenges and trends in urban regions; (2) Recycling city and its importance in the current debate on sustainability; (3) Identification and optimization of existing cycle approaches in urban habitats; (4) Analysis of the actual state as well as designation of developments and constraints; (5) Discussion on the interface between the sectors; (6) Options for action for the interaction between the actors in interdisciplinary topics; (7) Outline of ways and perspectives of the implementation of the &apos;&apos;Recycling City 2030&apos;&apos;.

  8. Formation of helium induced nanostructure &apos;fuzz&apos; on various tungsten grades

    Energy Technology Data Exchange (ETDEWEB)

    Baldwin, M.J., E-mail: mbaldwin@ferp.ucsd.ed [Center for Energy Research and Department of Mechanical and Aerospace Engineering, University of California-San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0417 (United States); Doerner, R.P. [Center for Energy Research and Department of Mechanical and Aerospace Engineering, University of California-San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0417 (United States)

    2010-09-30

    The response of a variety of W material grades to nanostructure &apos;fuzz&apos; formation is explored. W targets are exposed to He or D{sub 2}-0.2He plasmas in PISCES-B at 900-1320 K to below sputter threshold He{sup +} ions of energy 25-60 eV for up to 2.2 x 10{sup 4} s. SEM and XPS reveal nanoscopic reorganization of the W surface to a layer of &apos;fuzz&apos; of porosity {approx}90% as determined by a &apos;fuzz&apos; removal/weight loss method. The variability of &apos;fuzz&apos; growth is examined at 1120 K for 1 h durations: SR, SC and doped W grades - La{sub 2}O{sub 3} (1% wt.), Re (5% and 10% wt.), and TiC (1.5% wt.) developed 2-3 {mu}m thick &apos;fuzz&apos; layers, while a VPS grade developed a layer 4 {mu}m thick. An RC grade revealed additional &apos;fuzz&apos; at deep (>100 {mu}m) grain boundaries. However, heat treatment up to 1900 K produced reintegration of &apos;fuzz&apos; with the bulk and He release at {approx}1000 K and {approx}1400-1800 K due to depopulation from vacancy complexes.

  9. Aids to decision in selection of valve stem seals in accordance with the &apos;&apos;TA Luft&apos;&apos; requirements, 2002 edition; Entscheidungshilfen fuer die Auswahl von Spindelabdichtungen nach TA-Luft-Anforderungen - Ausgabe 2002

    Energy Technology Data Exchange (ETDEWEB)

    Wodara, G. [Phoenix Armaturen Werke Bregel GmbH, Volkmarsen (Germany)

    2005-12-01

    &apos;&apos;TA Luft&apos;&apos; (&apos;&apos;Technical Directive for Prevention of Air Pollution&apos;&apos;), 2002, specifies high-quality-sealing metal bellows with a downstream safety gland, or equivalent sealing systems, for the sealing of valva stems. According to &apos;&apos;TA Luft&apos;&apos;, sealing systems may be considered equivalent provided the temperature-specific rates of leakage are met in the VDI 2440 (November, 2000 edition) test and detection procedure. &apos;&apos;High-quality metal bellows with downstream safety gland&apos;&apos; and various &apos;&apos;spring-load gland packings&apos;&apos; are examined in this article on the criterion of the requirements of &apos;'TA-Luft'&apos;, on the bases of testing in accordance with TA Luft 2002 VDI 2440 and a test in accordance with DIN EN ISO 15 848, Part 1. The result: There is, for the bello with downstream safety gland, no alternative which fulfills all the requirements of &apos;&apos;TA Luft&apos;&apos;. The spring-loaded gland packing and, according to the relevant literature, the double gland packing with barrier fluid and exhausting, which is not examined here, do provide a potential alternative for lower load-cycle numbers. The fact that design specifications and the packing and valve manufacturers&apos; installation instructions were taken into account for valve stem surfaces, gap tolerances, packing-ring arrangement, and tightening torques for precompression and final compression, was decisive for fulfillment of the requirements of TA Luft, VDI 2440 in the tests examined in this article. (orig.)

  10. Transtornos de humor refratários a tratamento Treatment-resistant mood disorders

    Directory of Open Access Journals (Sweden)

    Rodrigo Machado-Vieira

    2007-10-01

    Full Text Available OBJETIVOS E MÉTODO: Os transtornos de humor estão entre os transtornos psiquiátricos mais prevalentes. Apesar de novas descobertas e avanços no estudo das bases neurobiológicas e abordagens terapêuticas no transtorno bipolar e depressão recorrente, elevadas taxas de recorrência, sintomas subsindrômicos persistentes e refratariedade terapêutica são aspectos clínicos desafiadores e precisam ser abordados. O objetivo desta revisão da literatura é o de avaliar os conceitos e critérios de resistência e refratariedade ao tratamento, e evidenciar as principais alternativas terapêuticas para transtornos do humor resistentes aos tratamentos disponíveis. RESULTADOS: Fatores genéticos, erro diagnóstico e de tratamento, não-aderência, e estressores biológicos e psicossociais podem levar à perda de mecanismos regulatórios e ao aumento na prevalência de casos de refratariedade nos transtornos de humor. Com relação aos tratamentos disponíveis, o uso de doses apropriadas, seguido por associação com um segundo ou terceiro fármaco, e após, se indicado, a troca de medicação, são etapas necessárias na busca de melhor eficácia. Entretanto, no paradigma de refratariedade terapêutica, tratamentos atuando em sistemas já conhecidos, especialmente monoaminas, freqüentemente apresentam limitada eficácia. Assim, a busca por tratamentos mais eficazes para os transtornos de humor torna-se um aspecto chave para diminuir sua morbidade. CONCLUSÃO: Estratégias focadas na regulação de vias ativadoras de neuroplasticidade, incluindo agentes antiglutamatérgicos, antagonistas de receptor glucocorticóide e neuropeptídeos, podem representar opções terapêuticas promissoras.OBJECTIVE AND METHOD: Mood disorders are the most prevalent psychiatric disorders. Despite new insights and advances on the neurobiological basis and therapeutic approaches for bipolar disorders and recurrent depression, elevated prevalence of recurrence, persistent

  11. Know-how management &apos;&apos;Rock mechanics and support methods for the gate roads in the German coal mining industry&apos;&apos;; Wissensmanagement &apos;&apos;Gebirgsmechanik und Ausbautechnik fuer Floezstrecken im deutschen Steinkohlenbergbau

    Energy Technology Data Exchange (ETDEWEB)

    Junker, M. [Deutsche Steinkohle AG, Herne (Germany). Servicebereich Technik und Logistik; Schmidt, R.

    2006-03-23

    The R+D-project for establishment of a database with the entire know-how of the last 30 years from the &apos;&apos;Rock mechanics and support methods for gate roads in the German coal mining industry&apos;&apos; has so far been carried out as planned. After adaptation to the project the selected computer system was introduced. A planning module with recorded operational cases and a structured literature database is thus available to the Competence Centre for Road Supports in the Mining Technology Department of the Technology and Logistics Service Division of DSK. (Orig.)

  12. Reply to &apos;&apos;Comment on &apos;Paramagnetic and ferromagnetic resonance studies on dilute magnetic semiconductors based on GaN&apos; &apos;&apos; [Phys. Status Solidi A 205, 1872 (2008)

    Energy Technology Data Exchange (ETDEWEB)

    Kammermeier, T. [Institut fuer Energie und Umwelttechnik e.V. (IUTA), Luftreinhaltung and Nachhaltige Nanotechnologie Unit, Bliersheimer Strasse 60, 47229 Duisburg (Germany); Fakultaet fuer Physik und CeNIDE, Universitaet Duisburg-Essen, 47057 Duisburg (Germany); Ney, A. [Fakultaet fuer Physik und CeNIDE, Universitaet Duisburg-Essen, 47057 Duisburg (Germany); Wieck, A.D. [Angewandte Festkoerperphysik, Ruhr-Universitaet Bochum, Universitaetsstr. 150, NB Building, 44780 Bochum (Germany)

    2011-08-15

    In a comment by Gehlhoff et al. on our work on &apos;&apos;Paramagnetic and ferromagnetic resonance studies on dilute magnetic semiconductors based on GaN&apos;&apos; [Phys. Status Solidi A 205, 1872 (2008)] the authors claim a contradictory explanation of angular dependent magnetic resonance measurements. Here we discuss their - solely based on computer simulations - claims. We show that an interpretation limited on magnetic impurities can hardly be used to explain the complex magnetic behavior. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  13. A criocirurgia como tratamento alternativo do xerodema pigmentoso = The criosurgery as alternative treatment of xeroderma pigmentosum

    Directory of Open Access Journals (Sweden)

    Antunes, Antonio Azoubel

    2007-01-01

    Full Text Available A criocirurgia consiste em tratar lesões patológicas da pele e mucosas pelo congelamento intenso da área afetada. Sua indicação deve obedecer a critérios de avaliação, como o aspecto macroscópico da lesão, tamanho, tipo histológico, localização e idade do paciente, sendo indicado para o tratamento das lesões provenientes do Xeroderma Pigmentoso (XP. O objetivo do presente estudo é instituir a experiência dos autores quanto ao uso da criocirurgia no tratamento de 12 pacientes com lesões em pele e mucosa da região da cabeça e pescoço associadas ao XP, em um período de 25 anos, discutindo suas aplicações e aspectos de sucesso e insucesso. Durante o período de abril de 1977 a abril de 2002 (25 anos, foram tratados pela criocirurgia, no Centro de Oncologia (CEON do Hospital Universitário Oswaldo Cruz (HUOC – Universidade de Pernambuco (UPE, Departamento de Cabeça e Pescoço – Hospital de Câncer de Pernambuco e na clínica privada de um dos autores, 1900 (mil e novecentos casos de pacientes portadores de lesões benignas e malignas da pele e mucosa na região de cabeça e pescoço, dos quais 12 pacientes (0,7% eram portadores de XP. Do total da amostra, 66,6% eram do sexo masculino e todos os casos ocorreram na 1ª e 2ª décadas de vida. A criocirurgia constitui-se um excelente método alternativo de tratamento para as lesões de pele e mucosa decorrentes do XP, sempre que indicada de maneira criteriosa

  14. Tratamento dos transtornos do comportamento de pacientes com demência

    Directory of Open Access Journals (Sweden)

    Tamai Sérgio

    2002-01-01

    Full Text Available No curso da demência, transtornos não-cognitivos comportamentais são altamente prevalentes. Esses sintomas psicológicos e comportamentais da demência (SPCD são mais importantes no dia-a-dia do que os déficits cognitivos, tanto para o paciente quanto para o cuidador, em termos de angústia e incapacitação causadas. Os SPCD freqüentemente levam à institucionalização. O raciocínio para o uso de drogas psicotrópicas está parcialmente baseado nas semelhanças fenomenológicas entre alguns comportamentos observados em pacientes idosos dementados e sinais e sintomas de transtornos psiquiátricos, como os transtornos depressivos, psicóticos ou ansiosos, em pacientes não-dementados. Na realidade, os SPCD são, com freqüência, qualitativamente diferentes daqueles que caracterizam os transtornos psicóticos, depressivos ou ansiosos. Os estudos de seguimento de tratamento sugerem que as drogas antipsicóticas são menos eficazes em pacientes com doença de Alzheimer ou demência de lobo frontal do que em pacientes com transtornos psiquiátricos. Abordagens não-farmacológicas são a primeira escolha no tratamento dos SPCD. Os inibidores da colinesterase no tratamento dos SPCD na doença de Alzheimer e na demência cortical difusa por corpos de Lewi representam uma abordagem terapêutica promissora.

  15. Tratamento dos Leiomiomas por Embolização das Artérias Uterinas

    Directory of Open Access Journals (Sweden)

    Messina Marcos de Lorenzo

    2001-01-01

    Full Text Available Objetivos: avaliar os resultados da embolização das artérias uterinas (EAU como tratamento do leiomioma uterino. Métodos: foram estudadas 18 mulheres com diagnóstico ultra-sonográfico de leiomioma uterino submetidas à EAU com partículas de álcool polivinílico (PVA. O acesso arterial foi realizado por punção da artéria femoral e a progressão do cateter foi monitorada até atingir seletivamente as artérias uterinas. A avaliação dos resultados foi realizada pelo estudo ultra-sonográfico antes e três meses após o procedimento. Foi realizado controle clínico evolutivo para avaliação das características menstruais e do volume uterino. Resultados: houve insucesso técnico em três casos por dificuldade de cateterização das artérias uterinas. O sangramento e a dismenorréia foram controlados no intervalo de três meses em 86 e 60% das pacientes, respectivamente. A média dos volumes uterinos iniciais foi de 381 cm³ e após 3 meses foi de 263 cm³. Houve redução média de 27,4% no volume uterino três meses após o tratamento. Três pacientes tiveram insuficiência ovariana clínica e laboratorial (20% dos casos. Conclusões: a EAU representa alternativa terapêutica para o tratamento dos leiomiomas uterinos. Em virtude do risco de insuficiência ovariana esse procedimento é reservado para pacientes com mais de 45 anos de idade ou com prole completa.

  16. The clock face guide to peroneal intraneural ganglia: critical &apos;'times'&apos; and sites for accurate diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Spinner, Robert J. [Mayo Clinic, Department of Neurologic Surgery, Rochester, MN (United States); Mayo Clinic, Department of Orthopedics, Rochester, MN (United States); Mayo Clinic, Department of Anatomy, Rochester, MN (United States); Luthra, Gauri [University College Cork, National University of Ireland, Cork (Ireland); Desy, Nicholas M. [McGill University School of Medicine, Department of Orthopedics, Montreal, Quebec (Canada); Anderson, Meredith L. [Mayo Clinic, Department of Radiology, Rochester, MN (United States); Amrami, Kimberly K. [Mayo Clinic, Department of Neurologic Surgery, Rochester, MN (United States); Mayo Clinic, Department of Radiology, Rochester, MN (United States)

    2008-12-15

    The aim of this study is to exploit the normal nature of peroneal nerve anatomy to identify constant magnetic resonance imaging (MRI) patterns in peroneal intraneural ganglia. This study is designed as a retrospective clinical study. MR images of 25 patients with peroneal intraneural ganglia were analyzed and were compared to those of 25 patients with extraneural ganglia and 25 individuals with normal knees. All specimens were interpreted as left-sided. Using conventional axial images, the position of the common peroneal nerve and either intraneural or extraneural cyst was determined relative to the proximal fibula and the superior tibiofibular joint using a symbolic clock face. In all patients, the common peroneal nerve could be seen between the 4 and 5 o&apos;clock position at the mid-portion of the fibular head. In patients with intraneural ganglia, a single axial image could reproducibly and reliably demonstrate both cyst within the common peroneal nerve at the mid-portion of the fibular head (signet ring sign) between 4 and 5 o&apos;clock and within the articular branch at the superior tibiofibular joint connection (tail sign) between 11 and 12 o&apos;clock; in addition, cyst within the transverse limb of the articular branch (transverse limb sign) was seen at the mid-portion of the fibular neck between the 12 and 2 o&apos;clock positions on serial images. Extraneural ganglia typically arose from more superior joint connections with the epicenter of the cyst varying around the entire clock face without a consistent pattern. There was no significant difference between the visual and template assessment of clock face position for all three groups (intraneural, extraneural, and controls). We believe that the normal anatomic and pathologic relationships of the common peroneal nerve in the vicinity of the fibular neck/head region can be established readily and reliably on single axial images. This technique can provide radiologists and surgeons with rapid and

  17. Analysis of &apos;&apos;new physics&apos;&apos; in the flavor sector using effective field theory methods

    Energy Technology Data Exchange (ETDEWEB)

    Dassinger, Benjamin M.

    2010-02-05

    The enormous amount of data collected by the B factories as well as the perspective concerning the upcoming experiments at the LHC provide us with the opportunity to perform high precision tests of the standard model. This dissertation presents two model independent precision tests of the weak sector of the standard model using extensions of the weak currents which are set up using effective field theory methods in order to control the size of the different contributions. Constraints on the coefficients of the terms can then be obtained by comparison with experimental results. The first analysis incorporates a test of the lefthandedness of the weak interaction in the quark sector. By introducing additional weak couplings the differential and total decay rates of the inclusive semileptonic decay anti B {yields} X{sub c}l anti {nu}{sub l} are calculated. The calculation includes the computation of the heavy-quark expansion which describes the interaction of the decaying b quark with respect to the background field of the B meson, up to order 1/m{sub b}{sup 4}. This has been done in a new, systematic way which does not involve the calculation of gluon matrix elements. Furthermore, radiative corrections have been included up to order O({alpha}{sub s}) including renormalization group running. The second part deals with the introduction of lepton flavor violating operators in the context of leptonic {tau} decays. These operators give rise to the effective four-fermion vertex {tau}{yields}ll{sup &apos;}l'&apos; as well as the subsequent radiative decay {tau}{yields}l{gamma}{sup *}{yields}ll{sup &apos;+}l{sup &apos;-}. The resulting Dalitz distributions turn out to predict completely different signatures for the radiative and the effective four-fermion vertices and provide the opportunity to check, whether the decay is induced either by a radiative or by an effective four-fermion vertex. Since different models which contain lepton flavor violation are normally more

  18. Characteristics of radioactive aerosols in 2014 near lavaliked fuel contained materials in premise 012/15 of the &apos;'Ukryttya'&apos; object

    International Nuclear Information System (INIS)

    Composition, concentrations and dispersity of radioactive aerosols in 2014 in premise 012/15 of the &apos;'Ukryttya'&apos; object, were are existed the lavaliked fuel contained materials (LCFM) are presented. The samples were taken on Petryanov&apos;s three-layer filters. At the same time concentrations of radon, thoron and their daughter products were definition with help of the seismic radon station and of radiometer &apos;&apos;Alfarad plus A&apos;&apos;. It was stated that concentration of beta-radiating (Σβ) aerosol-carriers (90Sr+90Y and 137Cs) was fluctuating with the range 0.2 - 3 Bq/m3. Besides, 137Cs share made 30 - 40 %. Ratio of 1&apos;37Cs/241Am concentrations was close to 150. Radionuclide carriers were aerosols with AMAD near 1 μm. Gamma-spectrometric measurements have demonstrated that ratios of radionuclides-products ChNPP Unit 4 accident in aerosol samples and LCFM specimens were characteristically different. It mean that LCFM destruction is altered slightly. Maximum volume activity of radon reached 200 - 300 Bq/m3. 212Pb concentrations - thoron daughter products were fluctuating within the range 0.7 - 33 Bq/m3, and its carriers were the particles of diameter, prevailing, 0.1 - 0.3 μm

  19. U-Pb zircon geochronology of &apos;'brasiliano'&apos; granitoids from the Serido orogenic belt (Borborema Province, NE Brazil). Ages U-Pb sur zircon de granitoides &apos;'brasilianos'&apos; de la ceinture du Serido (Province Borborema, NE Bresil)

    Energy Technology Data Exchange (ETDEWEB)

    Leterrier, J.; Bertrand, J.M. (Centre National de la Recherche Scientifique (CNRS), 54 - Nancy (France). Centre de Recherches Petrographiques et Geochimiques); Pin, C. (Clermont-Ferrand-2 Univ., 63 - Aubiere (France)); Jardim de Sa, E.

    1994-06-01

    Diorites previously attributed to an early stage of the &apos;brasiliano&apos; plutonic evolution of the Serido belt yielded U-Pb zircon age of 579 [+-]7 Ma. The age of associated granites is slightly younger although a synchronous emplacement of granites and diorites is suggested by field relationships. Such an age difference may result from difficulties to distinguish &apos;crystallization age&apos; from &apos;emplacement age&apos;, which is still to be determined precisely. (authors). 16 refs., 3 figs., 1 tab.

  20. Search for B Meson Decays to eta&apos; eta&apos; K

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2006-05-05

    The authors describe searches for decays of B mesons to the charmless final states {eta}&apos;{eta}&apos;K. The data consist of 228 million B{bar B} pairs produced in e{sup +}e{sup -} annihilation, collected with the BABAR detector at the Stanford Linear Accelerator Center. The 90% confidence level upper limits for the branching fractions are {Beta}(B{sup 0} {yields} {eta}&apos;{eta}&apos;K{sup 0}) < 31 x 10{sup -6} and {Beta}(B{sup +} {yields} {eta}&apos;{eta}&apos;K{sup +}) < 25 x 10{sup -6}.

  1. The countdown is running. The &apos;Endlagerkommission&apos; on the finishing straight

    International Nuclear Information System (INIS)

    Although the Site Selection Act (&apos;'Standortauswahlgesetz'&apos;) entered into force on 27 July 2013, the Commission on Storage of High-level Waste Materials&apos;&apos; held its inaugural meeting on 22 May 2014. One main task of the Commission is the preparation and submission of a report concerning the main issues for the site selection for a final high-level waste repository. Additionally the proposals should comprise a decision-making tool and recommendations for actions for the Bundestag and Bundesrat. In mid-February 2016 the Commission started to publish some draft parts of the report on the website of the Commission.

  2. PubliForum &apos;Electricity and Society&apos;. Citizen Panel Report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-06-01

    In the Citizen Panel&apos;s Report on &apos;Electricity and Society&apos; we present the first results of three intensive week-ends. In this document, 27 Swiss citizens have recorded their opinions on the future of our electricity supply system. Solutions are sought without making claims on having found the ultimate recipe. The recommendations are the result of an assessment made by a representative cross-section of the public - one could almost say &apos;the voice of the people&apos;. They reflect not only the public&apos;s apprehensions and worries, but also their ideas and desires. (authors)

  3. ANDRA&apos;s news; L&apos;actualite de l&apos;Andra

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This press kit presents the three missions of the French national agency of radioactive wastes (ANDRA) and the main highlights of these three missions for the second half of 2003: 1 - industrial mission: the very low radioactive waste disposal facility of Morvilliers (543 m{sup 3} of waste packages already stored), the Aube disposal facility (exploitation data), the Manche disposal facility (adaptation to new monitoring standards); 2 - the research mission: the Meuse/Haute-Marne laboratory (progress of works and experimental program), the mobilization of competences (international expertise of ANDRA&apos;s researches about deep underground disposal, the coordination of the European program ESDRED); 3 - the information mission: national inventory of radioactive wastes, publications and events, recall of ANDRA&apos;s missions. (J.S.)

  4. Tratamento da Doença de Chagas pelo Nifurtimox (Bayer 2502

    Directory of Open Access Journals (Sweden)

    Aluizio Prata

    1975-12-01

    Full Text Available Foram tratados 77 pacientes com doença de Chagas pelo nifurtimox, subdivididos em quatro grupos. Grupo I, com 30 pacientes na fase aguda. Somente oito doentes usaram a droga durante 120 dias, na dose inicial de 15 mg/kg de peso corporal e posteriormente de 10 mg. Vinte e dois pacientes tomaram dose insuficiente. Em quatro doentes (50% o xenodiagnóstico tornou-se negativo pós-tratamento; destes, três fizeram reação de Machado Guerreiro, a qual estava negativa. Houve um óbito por insuficiência cardíaca no 59 dia de tratamento. Seis pacientes apresentaram polineuropatia periférica. Grupo II, com 15 pacientes na fase crônica, tratados em ambulatório. Oito abandonaram o tratamento, mas cinco em dez que tomaram placebo fizeram o mesmo. Dos seis que tomaram a droga durante 120 dias e fizeram pelo menos um xenodiagnóstico pós-tratamento, havia quatro que estavam com os exames negativos. O tratamento não alterou o eletrocardiograma, a área cardíaca ou a radiografia do esôfago dos doentes e não evitou que um paciente viesse a desenvolver insuficiência cardíaca e um outro arritmia. Grupo III, com 15 pacientes na fase crônica, tratados com 10 mg/kg, durante 120 dias. Fizeram 12 xenodiagnósticos mensalmente, cada um com oito caixas contendo 10 T. infestans após o tratamento e somente 28,5% dos pacientes apresentaram todos os exames negativos. Houve acentuada redução da parasitemia, mesmo nos doentes não curados. O número de xenos positivos passou de 43% antes do tratamento para 24,4% após o mesmo e o número de caixas positivas caiu de 29,6% para 7%. Grupo IV, com 17 pacientes na fase crônica, tratados com 8 mg/kg ao dia, sendo que em oito durante 120 dias, em cinco durante 100 dias e em quatro durante 60 dias. A percentagem de doentes com os 12 xenos negativos pós-tratamento foi de 56,25. Também neste grupo houve redução de parasitemia, caindo a percentagem de xenos positivos de 76,5 antes do tratamento para 10,3 e a de

  5. O autocuidado para o tratamento de úlcera de perna falciforme: orientações de enfermagem

    OpenAIRE

    Amanda Martins; Debora Galvão Moreira; Emilia Matos do Nascimento; Enedina Soares

    2013-01-01

    O objetivo deste estudo foi verificar a eficácia do Programa do Autocuidado, pela progressão do processo cicatricial de úlcera da perna falciforme. Trata-se de um estudo longitudinal com abordagem quantitativa realizado com 40 clientes no setor de curativos de uma instituição de saúde pública, especializada no tratamento hematológico, situada no Rio de Janeiro. Para a coleta dos dados foi utilizado um instrumento aplicado no momento das consultas de enfermagem. Os dados foram analisados com o...

  6. Pré-tratamentos na secagem e reidratação de champignon em fatias

    Directory of Open Access Journals (Sweden)

    Hayana Juliani Mimura

    2014-04-01

    Full Text Available O objetivo deste trabalho foi avaliar o efeito de dois pré-tratamentos (pt na desidratação osmo-convectiva: Pré-tratamento químico a 20°C por 5min em solução de ácido cítrico, bissulfito de sódio e carbonato de cálcio a 0,1% cada (pt-ABC e por branqueamento a 80°C por 5min (pt-B, bem como a combinação pt-ABC seguido de pt-B (amostra:solução = 1:10 w/w. O pt-ABC provocou aumento de massa (13% em média entretanto o pt-B perda (-34% em média. A desidratação osmótica a 20°C por 60min em solução de NaCl a 10% reduziu a massa de fatias não pré-tratadas em 43%. Esse nível de redução de massa não pode ser atingido com o uso do pt-ABC, mas melhorou para 49% para fatias submetidas ao pt-B. Os pré-tratamentos reduziram o tempo de secagem (70°C e com circulação de ar de 18m³ h-1 de 150min para 60min para atingir o nível de atividade de água do produto seco igual ou menor a do produto comercial. As fatias submetidas ao pt-ABC ou do controle apresentaram boa capacidade de reidratação. As fatias que foram submetidas aos dois pré-tratamentos apresentaram coloração mais clara e menos enrugadas após secagem, aparência similar foi observada às do pt-ABC. O pt-ABC pode ser usado para se obter fatias de champignon seco com aspecto visual e capacidade de reidratação adequados para o desenvolvimento de novos produtos para consumo direto ou que necessite reidratação.

  7. O uso da crioterapia no tratamento das disfunções temporomandibulares

    OpenAIRE

    Renata Maria Moreira Moraes Furlan

    2015-01-01

    Esta pesquisa teve por objetivo realizar uma revisão integrativa sobre a produção científica referente ao uso da crioterapia no tratamento das disfunções temporomandibulares, caracterizando as técnicas utilizadas, duração de aplicação da técnica, área estimulada e frequência de realização. Foi realizado um levantamento da literatura nas bases de dados Medline, LILACS, SciELO, Biblioteca Cochrane e IBECS. Os termos utilizados foram: crioterapia,temperatura baixa, transferência de calor, hipote...

  8. Tratamento operatório de bolhas no enfisema bolhoso: uma simples drenagem

    OpenAIRE

    SAAD JR. ROBERTO; MANSANO MARCELO DOMINGUES; BOTTER MÁRCIO; GIANNINI JACQUELINE ARANTES; DORGAN NETO VICENTE

    2000-01-01

    Dez operações foram realizadas em oito doentes portadores de doença bolhosa. A drenagem fechada da bolha foi a operação feita em todos os doentes. Esta técnica, descrita inicialmente por Monaldi para o tratamento de abscessos pulmonares tuberculosos, foi utilizada com algumas modificações. Melhora dos sintomas e colapso total das bolhas foi obtido em nove procedimentos. Não houve mortalidade e os resultados foram compensadores. Esta técnica é um método simples de descompressão da bolha atravé...

  9. Tratamento operatório das bolhas pulmonares gigantes Surgical treatment of giant emphysematous lung bullae

    OpenAIRE

    Marcio Botter; Roberto Saad Júnior; Denise Aparecida Botter; Jorge Henrique Rivabem; Roberto Gonçalves; Vicente Dorgan Neto

    2007-01-01

    OBJETIVOS: A escassez de publicações nacionais a respeito desta doença no Brasil nos motivou a realizar o presente trabalho, cujos objetivos são descrever a evolução histórica e analisar os resultados do tratamento operatório das bolhas enfisematosas gigantes na Santa Casa de São Paulo. MÉTODOS: Avaliamos retrospectivamente, entre janeiro de 1979 a junho de 2005, os prontuários de 83 doentes submetidos a uma entre quatro modalidades operatórias: bulectomia por toracotomia, bulectomia por ciru...

  10. Efetividade do tratamento em fisioterapia na pubalgia num jogador de futsal

    OpenAIRE

    Silva, Ivone

    2011-01-01

    A pubalgia é uma inflamação que ocorre na região do osso púbis, ponto de origem – inserção de diversos músculos, como os adutores da coxa e os abdominais. É responsável pelo afastamento de atletas de diversas modalidades da sua prática desportiva. Objectivo: Analisar a efectividade do tratamento em fisioterapia num jogador de futsal profissional que apresenta sintomatologia de pubalgia. Método: Foi realizado um estudo de caso com um jogador de futsal de 28 anos atuante na posição ala/pivot. O...

  11. Os efeitos do óleo essencial decitrusaurantiumno tratamento de sobrepeso e obesidade

    OpenAIRE

    Anna Carolina Faria; Daniel Maurício de Oliveira Rodrigues

    2012-01-01

    Introdução: O objetivo deste estudo foi verificar os possíveis efeitos do óleo essencial de Citrusaurantiumvar. Amara no tratamento de Sobrepeso e obesidade Grau I. Método: Trata-se de um estudo clínico piloto duplo-cego randomizado, de natureza quantitativa, realizado na Clínica de Naturologia da UNISUL com 15 moradores de Palhoça/SC, com idade de 20 a 42 anos. Os participantes foram divididos, pela técnica de amostragem aleatória simples, em dois grupos: experimental (óleo essencial, n=8) e...

  12. Toxina botulínica como tratamento para fobia social generalizada com hiperidrose

    OpenAIRE

    Larissa da Rocha Lessa; Fontenelle, Leonardo F.

    2011-01-01

    CONTEXTO: Enrubescimento, tremores e transpiração excessiva são fenômenos frequentemente observados na fobia social. OBJETIVOS: Descrever a resposta de um paciente com o tipo generalizado de fobia social e hiperidrose à terapia cognitivo-comportamental aliada à toxina botulínica. MÉTODO: Relato de caso único. RESULTADOS: O Sr. A, 20 anos, estudante universitário, procurou tratamento por apresentar sintomas compatíveis com os diagnósticos de fobia social e depressão. O Sr. A também apresentava...

  13. Atividade de bioterápicos para o tratamento de mastite subclínica bovina.

    OpenAIRE

    Almeida, Anna Christina de; Soares, Thais Maria Pinheiro; Silva, Délcio Bueno; Silva, Bárbara Cardoso da Mata; Almeida, Patricia Natalicia Mendes; Santos, Claudinei Alves dos

    2011-01-01

    Objetivou-se avaliar a eficiência de bioterápicos administrados por meio da ração para o tratamento de mastite subclínica bovina causada por Staphylococcus aureus. O bioterápico na potência 12 CH foi produzido a partir de amostras de leite dos quartos infectados e administrado na dosagem de 0,5g do produto em pó por animal, espalhado sobre o alimento oferecido no momento da ordenha, duas vezes ao dia, durante 30 dias. Um grupo controle foi mantido nas mesmas condições recebendo placebo. Análi...

  14. Diretrizes brasileiras para o tratamento da narcolepsia Brazilian guidelines for the treatment of narcolepsy

    OpenAIRE

    Flávio Alóe; Rosana Cardoso Alves; John F. Araújo; Alexandre de Azevedo; Andrea Bacelar; Márcio Bezerra; Lia Rita Azeredo Bittencourt; Guilherme Bustamante; Tania Aparecida Marchiori de Oliveira Cardoso; Alan L. Eckeli; Regina Maria França Fernandes; Leonardo Goulart; Márcia Pradella-Hallinan; Rosa Hasan; Heidi Haueisen Sander

    2010-01-01

    Este artigo relata as conclusões da reunião de consenso da Associação Brasileira de Sono com médicos especialistas brasileiros sobre o tratamento da narcolepsia, baseado na revisão dos artigos sobre narcolepsia publicados entre 1980 e 2010. Os objetivos do consenso são valorizar o uso de agentes avaliados em estudos randomizados placebo-controlados, emitir recomendações de consenso para o uso de outras medicações e informar pontos importantes a respeito da segurança e efeitos adversos das med...

  15. Clínica(s: diagnóstico e tratamento

    Directory of Open Access Journals (Sweden)

    Priszkulnik Léia

    2000-01-01

    Full Text Available O artigo analisa os pressupostos que delimitam o domínio da clínica médica (clínica positiva e da clínica psicanalítica, duas configurações diferentes de clínica, que se utilizam de referenciais muito próprios que determinam trabalhos distintos. Levanta um breve histórico e examina a maneira de cada profissional se posicionar frente ao sintoma do paciente, ao processo de diagnóstico e de tratamento.

  16. Endovascular treatment for intracranial infectious aneurysms Tratamento endovascular de aneurismas infecciosos intracranianos

    Directory of Open Access Journals (Sweden)

    Eduardo Wajnberg

    2008-12-01

    Full Text Available OBJETIVE: To re-enforce an alternative, less aggressive treatment modality in the management of intracranial infectious aneurysms. METHOD: We present a series of five patients with infectious endocarditis and intracranial infectious aneurysms (mycotic aneurysms managed by means of endovascular treatment. RESULTS: Endovascular treatment was executed technically uneventfully in all patients. Three patients had favorable clinical outcome: two were classified as Glasgow Outcome Scale 4/5, and one had total neurological recovery (GOS 5/5. Two patients died (GOS 1/5, one in consequence of the initial intracranial bleeding and the other after cardiac complications from endocarditis and open-heart surgery. CONCLUSION: Endovascular techniques are an expanding option for the treatment of IIAs. It has been especially useful for infectious endocarditis patients with IIA, who will be submitted to cardiac surgery with cardiopulmonary bypass and anticoagulation, with the risk of intracranial bleeding.OBJETIVO: Enfatizar o método endovascular como uma opção de tratamento alternativa e menos agressiva no tratamento de aneurismas infecciosos intracranianos. MÉTODO: Apresentamos uma série de cinco pacientes com endocardite infecciosa e aneurismas infecciosos intra-cranianos (aneurismas micóticos tratados através da via endovascular. RESULTADOS: O tratamento endovascular teve sucesso técnico e sem intercorrências relacionadas ao cateterismo em todos os casos. Três pacientes tiveram desfecho clínico favorável: dois com escala de regeneração de Glasgow 4/5 e um com recuperação neurológica completa (GOS 5/5. Dois pacientes tiveram desfecho desfavorável (GOS 1/5, um devido às conseqüências do sangramento intracraniano inicial e outro devido a complicações cardíacas da endocardite e cirurgia de troca valvar. CONCLUSÃO: As técnicas endovasculares são uma nova opção de tratamento dos aneurismas infecciosos intracranianos. Ela é especialmente

  17. Florais de bach como terapia complementar no tratamento dos sintomas de DDAH

    OpenAIRE

    Hellen Karla Oliveira Marques

    2012-01-01

    Introdução: O artigo aborda os Florais de Bach como Terapia complementar no tratamento dos sintomas dodistúrbio de déficit de atenção e hiperatividade (DDAH) ou transtorno de déficit de atenção e hiperatividade(TDAH), um problema de saúde mental comum em crianças, caracterizado por distração, inquietação,impulsividade e transtornos de aprendizagem. Se o quadro persiste até a fase adulta, o portador tem sua vidaprofissional e pessoal afetada. A realidade do transtorno em crianças no Estado de ...

  18. Tratamento da anemia ferropriva com ferro por via parenteral Iron deficiency anemia treatment with parenteral iron

    Directory of Open Access Journals (Sweden)

    Rodolfo D. Cançado

    2010-06-01

    Full Text Available Embora o ferro por via oral seja considerado a primeira opção de tratamento da deficiência de ferro, em algumas situações específicas, a administração de ferro por via parenteral é uma opção terapêutica que deve ser considerada. Diferentemente do ferro dextran de alto peso molecular utilizado na década de 80 e lembrado como um composto associado ao alto risco de reação anafilática e morte, o desenvolvimento e comercialização de novos compostos com ferro para uso parenteral, sobretudo por via endovenosa - como o ferro sacarato, ferro gluconato e, mais recentemente, a carboximaltose férrica - , tem se tornado cada vez mais uma alternativa terapêutica segura e efetiva, e tem possibilitado ampliar o leque de indicações desta modalidade de tratamento além da nefrologia, como obstetrícia e ginecologia, cirurgia, pediatria, gastroenterologia, hematologia e hemoterapia. Os autores revisam as principais indicações do tratamento com ferro por via parenteral, analisam as principais drogas disponíveis para a correção da anemia ferropriva por via endovenosa e propõem uma estratégia de investigação diagnóstica, tratamento e seguimento laboratorial dos pacientes com indicação desta opção terapêutica.Although oral iron is generally considered the first choice in the treatment of iron deficiency, in some specific situations, parenteral iron administration is a therapeutic option that should be considered. Different to the high-molecular-weight iron dextran utilized in the eighties and remembered as a compound associated with a high risk of anaphylaxis and death, the development and marketing of newer preparations for parenteral, in particular endovenous, administration, such as iron sucrose, ferric gluconate and more recently ferric carboxymaltose, are becoming a more effective and safe therapeutic alternative, that have extended the range of indications beyond nephrology to obstetrics and gynecology, surgery, pediatrics

  19. Desenvolvimento de matrizes biomiméticas como substitutos de pele destinados ao tratamento de queimaduras

    OpenAIRE

    Gomes, Susana Raquel Rodrigues

    2013-01-01

    Dissertação para obtenção do Grau de Doutor em Engenharia Biomédica A Engenharia de Tecidos apresenta actualmente soluções comerciais, para o tratamento de lesões provocadas por queimadura com perda total de pele, que não preenchem todos os requisitos para serem denominados de substitutos definitivos de pele. O objectivo deste trabalho consistiu no desenvolvimento e caracterização físico-química e biológica da componente dérmica de um substituto de pele baseada numa matriz de nanofib...

  20. Compressed &apos;energy logs&apos;; Energiatukit tulevat

    Energy Technology Data Exchange (ETDEWEB)

    Fredriksson, T.

    1999-07-01

    In Sweden the utilization of forest fuels exceeds 5 million m{sup 3}/a. Two different solutions have been developed for compacting of the logging residues of final fellings. The operating principles of these methods differ from each other. Both these methods compress logging residues to &apos;energy logs&apos;, which can be processed and transported by ordinary forest machines and lorries, used for harvesting of timber. Fiberpack Ab has developed a machine which can compress logging residues or trees without any larger restrictions for raw material. Long tops and trees under 30 cm diameter can be compressed into cylindrical pieces, the diameter of which are 0.7 m, while the length can be defined freely. However, in practical operation the length is usually 3.2 m which enables in long-distance transportation the full load of a timber-lorry. In principle the Fiberpack can produce as long energy log as the amount of logging residues enable. Transportation defines the length of the log. Fiberpac-unit weights six tons, and the width in operational condition is 5.8 m. The length of the unit is 2.4 m and the height 1.9 m. The operation of the equipment has been reliable. Compacting of the logging residues occurs in three stages. In pre-compassion the residues are compressed between two rollers, in the second stage it is compressed further in square-shaped frame, after which it undergoes final compression and binding. The average weight of the &apos;logs&apos; is 550 kg. A normal timber-trailer takes 65-70 logs. The production of Fiberpac is 15-20 logs per hour. Frozen and snowy raw material is the hardest raw material, but both fresh and dried logging residues can be used for production of logs. The price of one Fiberpac-unit is about 1.4 million SEK. Another alternative is the machine developed by Wood Pac Ab, which resembles a cigarette roller. A medium-sized forest machine is used as the basic machine. The minimum power demand is 120 kW, and the efficiency of the

  1. Measuring Beliefs in Centimeters: Private Knowledge Biases Preschoolers&apos; and Adults&apos; Representation of Others&apos; Beliefs

    Science.gov (United States)

    Sommerville, Jessica A.; Bernstein, Daniel M.; Meltzoff, Andrew N.

    2013-01-01

    A novel task, using a continuous spatial layout, was created to investigate the degree to which (in centimeters) 3-year-old children&apos;s ("N" = 63), 5-year-old children&apos;s ("N" = 60), and adults&apos; ("N" = 60) own privileged knowledge of the location of an object biased their representation of a…

  2. Whose education affects a child&apos;s nutritional status? From parents&apos; to household&apos;s education

    OpenAIRE

    Francesco Burchi

    2012-01-01

    BACKGROUND The paper engages in the ongoing debate regarding the determinants of child nutrition in developing countries and stresses the potential contribution of the education of household members other than the child&apos;s parents. OBJECTIVE The aim of the paper is threefold: (1) to verify whether there is evidence of the key role of parents&apos; education for children&apos;s nutrition; (2) to explore the possible presence of the externalities generated by the literacy of household membe...

  3. OJT. make &apos;em or break &apos;em

    Energy Technology Data Exchange (ETDEWEB)

    Arner, S.A.

    1992-01-01

    On-the-job training (OJT) has been with us in varying forms for longer than perhaps any other type of training. In reality, OJT is a process for accomplishing change; change in an employee&apos;s ability to perform assigned job duties. However, bringing about that change can often be a difficult process. A clear understanding of what change really is and what it entails is essential to easing its process. this document discusses the methodology in OJT and emphasizes the importance of communications in this process.

  4. Dat&apos;a&apos; RTE - &apos; Balance Responsible data &apos; Service. You would like to manage your activities more effectively, and that&apos;s why RTE is offering new services that give you access to personalized data; Dat&apos;a&apos; RTE offre &apos;&apos;donnees de responsable d&apos;equilibre'&apos;. Vous souhaitez mieux piloter vos activites, RTE vous propose un nouveau service de mise a disposition de donnees personnalisees

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-06-01

    RTE, the French manager of the power transportation network, already offers a service under which it publishes public data on its web site ; it aims to improve the way the electricity market works in a transparent and nondiscriminatory fashion. To better respond to the needs of actors in the electricity market, RTE has developed new Dat&apos;a&apos; RTE services, giving them access to detailed, personalized and confidential data. Dat&apos;a&apos; RTE is the main electronic channel used for exchanging personalized data between RTE and customers. The &apos;Balance Responsible Data&apos; service completes and enhances the other services associated with the &apos;Balance Responsible Entity&apos; service. For a detailed picture and greater reactivity, the customers have access to the basic data used to calculate imbalances as soon as they are processed by RTE. They become definitive from the point in time specified in the Balance Responsible Entity contractual documents. The price of this service is dependent upon the size of the customer&apos;s Balance Responsible perimeter.

  5. 3&apos;,8&apos;&apos;-biisokaempferide, a cytotoxic biflavonoid and other chemical constituents of Nanuza plicata (Velloziaceae)

    Energy Technology Data Exchange (ETDEWEB)

    Pinto, Meri Emili F.; Silva, Marcelo Sobral da; Barbosa Filho, Jose Maria; Castello-Branco, Marianna Vieira S.; Agra, Maria de Fatima; Tavares, Josean Fechine, E-mail: marcelosobral@ltf.ufpb.b [Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB (Brazil). Lab. de Tecnologia Farmaceutica; Schindler, Elisabete; El-Bacha, Ramon dos Santos [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil). Inst. de Ciencias da Saude. Lab. de Neuroquimica e Biologia Celular

    2010-07-01

    A novel biflavonoid, named 3&apos;,8&apos;&apos;-biisokaempferide (1), along with the known compounds amentoflavone (2), patagonic acid (3), (4aR,5S,6R,8aR)-5-[2-(2,5-Dihydro-5-methoxy-2-oxofuran- 3-yl)ethyl]-3,4,4a,5,6,7,8,8a-octahydro-5,6,8a- trimethylnaphthalene-1-carboxylic acid (4), 5-caffeoylquinic acid methyl ester (5), 3,5-di-caffeoylquinic acid (6) and luteolin (7), were isolated of the leaves from Nanuza plicata. The compounds 3, 4, 5 and 6 are reported for the first time in Velloziaceae. The structures of the compounds were elucidated on the basis of spectroscopic methods, especially NMR and MS analyses. The cytotoxicity of 3&apos;,8&apos;&apos;-biisokaempferide was studied in cultures of human glioblastoma GL-15 cells. The effective concentration, which killed 50 % of cells after 72 h was 36.5 {mu}mol L{sup -1}. Changes in cellular morphology, including retraction and degradation of cytoplasm, were observed when cells were treated with concentrations from 20 {mu}mol L-1 of 3&apos;,8&apos;&apos;-biisokaempferide for 72 h. (author)

  6. Innovative casting technology for the manufacture of near-net-shape crankshafts; Innovative giesstechnologische Entwicklungen zur Herstellung von &apos;'Endnah-Guss-Kurbelwellen'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Heck, K. [Audi AG, Ingolstadt (Germany); Dieterle, U. [Halberg Guss GmbH, Saarbruecken-Brebach (Germany); Kleine, A.; Sahm, P.R. [Technische Hochschule Aachen (Germany). Lehrstuhl fuer das Gesamte Giessereiwesen und Giesserei-Institut

    1999-07-01

    The reported technology solution for manufacturing a near-net-shape crankshaft is the outcome of a cooperation between three project teams of experts in the fields of casting, CNB grinding, and finishing. The casting process for near-net-shape crankshafts, the geometry design, the materials and properties are explained. The entire concept reduces the reuqired work volume by about 25%, and the throuput time by about 30%. (orig./MM) [German] Bedingt durch die Komplexitaet der Kurbelwellenfertigung erfolgte eine Projektorganisation unter Beruecksichtigung des Simultaneous-Engineering, das zu einer engen Zusammenarbeit zwischen den insgesamt drei Projektteams der Bereiche &apos;Giessen&apos;, &apos;CBN-Schleifen&apos; und &apos;Finishen&apos; fuehrte. Konkret erlaubt das als Endnah-Guss-Kurbelwellen-Technologie bezeichnete Loesungskonzept eine Verringerung der Arbeitsvorgaenge um ca. 25% und eine Reduzierung der Durchlaufzeit um ca. 30%. (orig.)

  7. Myonecrosis of Behcet&apos;s disease

    Energy Technology Data Exchange (ETDEWEB)

    Stubbs, Alana Y. [Southern Arizona Veterans Administration Health Care System, Department of Radiology, Tucson, AZ (United States); Taljanovic, Mihra S. [University of Arizona HSC, Radiology and Orthopaedic Surgery, Department of Radiology, Tucson, AZ (United States); Massey, Brandon Z. [The Village Offices, Institute for Plastic Surgery and Peripheral Nerve Surgery, Tucson, AZ (United States); Graham, Anna R. [University of Arizona HSC, Department of Pathology, Tucson, AZ (United States); Friend, Christopher J.; Walsh, Joshua A. [Inland Imaging, LLC, Spokane, WA (United States)

    2008-04-15

    Behcet&apos;s disease is an inflammatory disease of unknown cause characterized by intermittent episodes of acute inflammation manifested by oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. We report a rare case of myonecrosis associated with Behcet&apos;s disease. Myonecrosis of Behcet&apos;s disease can mimic soft tissue abscess and therefore awareness of this entity in the appropriate clinical setting is important for initiation of appropriate and timely treatment. (orig.)

  8. &apos;Minergie&apos; on a large scale; Minergie im Grossformat

    Energy Technology Data Exchange (ETDEWEB)

    Hawkins, A. C.

    2007-07-01

    This article takes a look at two housing estates in the suburbs of Zurich, Switzerland, that conform to &apos;Minergie&apos; low energy-consumption standards. In contrast to single-family homes normally associated with the &apos;Minergie&apos; low energy-consumption label, here, two &apos;Minergie&apos; housing estates each with a number of apartment blocks are looked at. The systems for providing regulated fresh air with heat recovery are described. In one of the estates, heat is collected from a nearby sewer via heat-exchangers and, together with a heat-pump system, is used to heat the apartments. Nearby, in the other &apos;Minergie&apos; estate, a large, mains-connected photovoltaics plant is used to meet the net power requirements of a heat-pump-based heating system. In summer, power is sold to the local electricity utility.

  9. Those who &apos;Cry Wolf&apos; about nuclear safety damage their own credibility

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Redditch (United Kingdom)

    2016-06-15

    Do you recall the fable of the boy who cried wolf? I was reminded of this following the latest call by Germany&apos;s Federal Environment Minister, Barbara Hendricks, for Belgium to take two of its nuclear reactors off the grid, citing &apos;'questions'&apos; about the units&apos; safety. Those in positions of power and influence in one country should take care to be as responsible in their dealings with their neighbours as they are in handling domestic matters of state. Those who see &apos;danger&apos; where there is none are not being good neighbours. They are generating fear and alarm without good cause and should mind their own business.

  10. ApoE allele frequencies in Italian sporadic and familial Alzheimer's disease.

    Science.gov (United States)

    Sorbi, S; Nacmias, B; Forleo, P; Latorraca, S; Gobbini, I; Bracco, L; Piacentini, S; Amaducci, L

    1994-08-15

    Recent studies have provided evidence of association of apolipoprotein E (ApoE) epsilon 4 allele and late onset familial and sporadic Alzheimer's disease (AD). Epidemiological studies have established allelic variation at the ApoE locus. We have analyzed the ApoE gene polymorphism in a sample of 446 Italian subjects. Our data confirm a significant association between epsilon 4 allele and sporadic AD. The frequency of epsilon 4 allele in early onset familial AD patients was comparable to control values suggesting that epsilon 4 allele does not represent a risk factor for early onset familial AD (EOFAD). Moreover, we found a not previously reported association between ApoE epsilon 2 allele and sporadic AD and EOFAD. PMID:7824157

  11. Special Data Collection System (SDCS) NTS Event &apos;Bulkhead&apos;, 27 April 1977. Technical report

    Energy Technology Data Exchange (ETDEWEB)

    Naylor, G.R.; Dawkins, M.S.

    1978-12-18

    This event report contains seismic data from the Special Data Collection System (SDCS), and other sources for the &apos;Bulkhead&apos; event. The report also contains epicenter information from seismic observations.

  12. Atoms of helium in interstellar and interplanetary medium. 1. Observations of scattering ultraviolet radiation in lines of HI lambda 1216 A and HeI lambda 584 A by the &apos;&apos;Prognoz-5&apos;&apos; and &apos;&apos;Prognoz-6&apos;&apos; satellites

    Energy Technology Data Exchange (ETDEWEB)

    Burgin, M.S.; Kurt, V.G.; Mironova, E.N.; Prokhorenko, V.I.; Ehjsmont, N.A.; Berto, Zh.L.; Dalod' e, F.

    A review of observation results of the joint Soviet- French experiment on the measurement of scattering ultraviolet radiation in interplanetary medium in HIlambda1216 A and HeI 584 A hydrogen lines, is presented. The four-channel photometer Oas installed at two high-apogee satellites of &apos;&apos;Prognoz-5&apos;&apos; and &apos;&apos;Prognoz-6&apos;&apos;. The sky scanning was performed due to satellite rotation around its axis directed to the Sun. A vessel with hydrogen was set up in the HILsub(..cap alpha..) channel in order to measure the Lsub(..cap alpha..) line width. All parameters connected with the Sun motion in interplanetary medium were determined.

  13. Tratamento cirúrgico da hipertensão porta na esquistossomose mansoni

    Directory of Open Access Journals (Sweden)

    Petroianu Andy

    2003-01-01

    Full Text Available Define-se a hipertensão porta pela presença de um gradiente de pressão venosa hepática superior a 5mmHg. Ela é causada geralmente pelo aumento da resistência do leito vascular porta-hepático em decorrência de obstrução ao fluxo sanguíneo. Nas formas graves da esquistossomose há aumento progressivo da pressão porta e o desenvolvimento de varizes nos órgãos intra-abdominais, no retroperitônio e na parede do abdômen. A principal complicação desse processo é o sangramento digestivo, proveniente, na maioria dos casos, das varizes esofágicas e gástricas. Para o tratamento, diversos procedimentos clínicos (propranolol, somatostatina e octeotrida, endoscópicos (escleroterapia, clipes e ligaduras de varizes, vasculares (TIPS - shunt intra-hepático transjugular portasistêmico e cirúrgicos (derivações portassistêmicas e desconexões portavarizes têm sido propostos. Neste artigo, o autor apresenta revisão crítica sobre os vários tratamentos propostos, enfatizando os procedimentos cirúrgicos.

  14. Biossegurança na perspectiva da equipe de enfermagem de Unidades de Tratamento Intensivo

    Directory of Open Access Journals (Sweden)

    Cátia Inácia Brand

    2014-01-01

    Full Text Available Trata-se de um estudo descritivo, com abordagem qualitativa, que teve como objetivo investigar saberes e práticas da equipe de enfermagem sobre biossegurança em Unidades de Tratamento Intensivo, bem como identificar situações de risco biológico a que o trabalhador está exposto e a adesão das unidades à Norma Regulamentadora nº 32. A coleta de dados foi feita por meio de entrevista e observação, no primeiro semestre de 2012, e o tratamento dos dados deu-se mediante análise temática. O estudo permitiu verificar adesão parcial às normas de biossegurança por parte das instituições e profissionais pesquisados e a deficiência de discussões sobre o tema nos espaços de educação continuada. O fomento de iniciativas para a educação de práticas seguras e a atualização constitui-se como promotor de saúde, além da prevenção de exposições jurídicas pelas infrações sanitárias assim configuradas.

  15. Fístula arteriovenosa coronário- pulmonar: tratamento cirúrgico

    Directory of Open Access Journals (Sweden)

    Cláudio Albernaz CÉSAR

    1997-07-01

    Full Text Available Fístulas arteriovenosas coronárias pertencem a um grupo de lesões cardíacas de difícil diagnóstico, por não apresentarem sintomas; quando suspeitadas de ocasionar o quadro clínico de um paciente, ou descobertas em exame de rotina, devem ser pesquisadas para o tratamento adequado. É relatado o caso de homem de 65 anos de idade, com história de precordialgia súbita, evoluindo para IAM de parede inferior, cuja investigação revelou a presença de fístulas de artérias coronárias direita e esquerda para tronco pulmonar. Após tratamento clínico seguido da operação, demonstrou resultados satisfatórios.Coronary arteriovenous fistulas belong to a group of cardiac pathologies that are rarely diagnosed because they do not present symptoms. However, when suspected of causing the clinical picture, they must be investigated to determine adequate treatment. The case of a 65-year-old man with a history of sudden angina, progressing to acute myocardial infarction of the inferior wall is presented. After diagnostic investigation, the presence of right and left coronary arteriovenous fistulas to pulmonary artery were found. After surgical and clinical treatment, the patient's course was satisfactory.

  16. Reboxetina no tratamento da bulimia nervosa Reboxetine in the treatment of bulimia nervosa

    Directory of Open Access Journals (Sweden)

    Simone Mancini Castilho

    2003-06-01

    Full Text Available É vasta a literatura demonstrando a eficácia dos antidepressivos inibidores seletivos da recaptação de serotonina na Bulimia Nervosa, diminuindo a freqüência do comportamento alimentar compulsivo e dos vômitos. A boa resposta terapêutica aos agentes farmacológicos noradrenérgicos, como a desipramina e a reboxetina, embora menos encontrada na literatura, também já foi documentada. O presente relato de caso descreve o tratamento de uma paciente com Bulimia Nervosa utilizando-se reboxetina na dose de 4 a 8 mg ao dia. A resposta terapêutica vem confirmar os resultados favoráveis do uso desta droga no tratamento da Bulimia Nervosa.There is a substancial body of literature demonstrating the efficacy of selective serotonin reuptake inhibitors antidepressants (SSRI in reducing binge eating and vomiting frequency in Bulimia Nervosa. Good therapeutic response to noradrenergic agents, like desipramine and reboxetine, though not frequently reported in literature, has already been demonstrated. This case report describes the treatment of Bulimia Nervosa with reboxetine (4 to 8 mg/day and its favorable therapeutic results.

  17. Tratamento farmacológico dos transtornos alimentares Pharmacological treatment of eating disorders

    Directory of Open Access Journals (Sweden)

    Jose C Appolinario

    2002-12-01

    Full Text Available O tratamento dos transtornos alimentares (TA geralmente exige uma abordagem multidisciplinar em que a farmacoterapia é adjuvante de abordagens psicológicas e nutricionais. Psicotrópicos são indicados para a maioria dos pacientes com TA para tratar as comorbidades e também os sintomas chamados nucleares. Progressos importantes estão ocorrendo nos últimos anos. Este artigo apresenta uma revisão das evidências atuais e perspectivas futuras para o tratamento farmacológico da anorexia nervosa, bulimia nervosa e do transtorno da compulsão alimentar periódica.The treatment of eating disorders (ED usually involves a multidisciplinary approach and pharmacotherapy is adjunctive to psychological and nutritional interventions. Psychotropic agents are prescribed for most patients with ED to treat both the comorbid conditions and ED core symptoms. Important progresses have occurred in the last years. We present an overview of the current evidences and future directions in the pharmacological treatment of anorexia nervosa, bulimia nervosa and binge eating disorder.

  18. Uso de ácidos graxos essenciais no tratamento de úlcera venosa: relato de caso

    Directory of Open Access Journals (Sweden)

    Nayana Nobre

    2012-05-01

    Full Text Available Nesse estudo relata-se o uso de ácidos graxos essenciais (AGE no tratamento de úlcera venosa em membro inferior esquerdo de um paciente do sexo masculino de 60 anos. O tratamento foi realizado nas Clínicas Integradas Izabela Hendrix.  A coleta dos dados foi realizada por meio de anamnese  e exame físico do paciente. Na avaliação da lesão foram realizadas medidas geométricas desde o momento em que o paciente procurou o serviço, bem como foram feitos registros fotográficos ao longo do atendimento. Ao final de três meses a lesão obteve sua completa cicatrização. Não houve relato de desconforto ou qualquer complicação durante o uso do AGE, o que permite afirmar que o produto apresentou eficácia terapêutica para esse caso em particular.   

  19. A orbifloxacina no tratamento das cistites bacterianas em gatos domésticos

    Directory of Open Access Journals (Sweden)

    Reche Junior Archivaldo

    2005-01-01

    Full Text Available O presente estudo teve como objetivos, avaliar o uso da orbifloxacina nas cistites bacterianas de felinos, e seus possíveis efeitos colaterais, mormente a nefro e/ou hepatotoxicidade. Para tanto, foram colhidas amostras de urina de 53 gatos com históricos variados, mas com predisposição à infecção urinária. A cistite bacteriana foi comprovada, através de exame microbiológico, em 13 pacientes. No entanto, apenas 10 apresentaram infecção por agentes sensíveis a orbifloxacina. Esses 10 pacientes foram então submetidos ao tratamento com orbifloxacina na dose de 2,5mg kg-1 a cada 24 horas por 10 dias. Não houve crescimento bacteriano nas amostras de urina submetidas à cultura, 72 horas após a interrupção do tratamento. Não foram observados sinais de nefro e/ou hepatotoxicidade nesses pacientes, uma vez que os níveis séricos de alanina aminotransferase (ALT, aspartato aminotransferase (AST, fosfatase alcalina (FA, albumina, uréia e creatinina não tiveram variação significativa após o uso do fármaco. Portanto, os resultados apresentados sugerem que a orbifloxacina pode ser usada como agente antimicrobiano nas infecções urinárias de felinos.

  20. The role of bioenergy in the energy transition. The &apos;&apos;Smart Bioenergy&apos;&apos; concept; Die Rolle der Bioenergie in der Energiewende. Das &apos;&apos;Smart Bioenergy&apos;&apos;-Konzept

    Energy Technology Data Exchange (ETDEWEB)

    Thraen, Daniela [Helmholtz-Zentrum fuer Umweltforschung - UFZ, Leipzig (Germany). Dept. Bioenergie (BEN); DBFZ Deutsches Biomasseforschungszentrum gGmbH, Leipzig (Germany). Bereich Bioenergiesysteme; Seitz, Stefanie B.; Wirkner, Ronny; Nelles, Michael [DBFZ Deutsches Biomasseforschungszentrum gGmbH, Leipzig (Germany). Bereich Bioenergiesysteme

    2016-08-01

    The energy system&apos;s transformation away from fossil and therefore finite resources and ecological harmful use towards renewable energy sources and sustainable forms of usage proceeds. But even after 35 years, the German energy transition has yet not reached its ambitious goals. Moreover, in the recent years the progress has stagnated in certain areas. This is due to the fact that one of the central challenges of the energy system&apos;s changeover to an sole use renewable energy (RE) have not yet mastered: the reliable and stable delivery of RE for all energy dependent sectors starting form electricity via heat to mobility in the face of fluctuating energy sources like sun and wind. Bioenergy with its flexible use of innovative technologies and smart integration in the overall system is therefore vital to grant stability of energy supply. Furthermore, bioenergy can recourse on sustainable resources and may become therefore the backbone of the future bioeconomy. For this purpose an integrative approach is necessary that aligns the aforementioned building blocks in a cohesive whole: the Smart Bioenergy concept - that will be presented here with its elements but also open questions and challenges.

  1. Schroedinger-Newton &apos;collapse&apos; of the wavefunction

    Energy Technology Data Exchange (ETDEWEB)

    Van Meter, J R, E-mail: james.r.vanmeter@nasa.gov [Department of Physics, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250 (United States)

    2011-11-07

    It has been suggested that the nonlinear Schroedinger-Newton equation might approximate the coupling of quantum mechanics with gravitation, particularly in the context of the Moeller-Rosenfeld semiclassical theory. Numerical results for the spherically symmetric, time-dependent, single-particle case are presented, clarifying and extending previous work on the subject. It is found that, for a particle mass greater than 1.14({h_bar}{sup 2}/(G{sigma})){sup 1/3}, a wave packet of width {sigma} partially &apos;collapses&apos; to a groundstate solution found by Moroz, Penrose and Tod, with excess probability dispersing away. However, for a mass less than 1.14({h_bar}{sup 2}/(G{sigma})){sup 1/3}, the entire wave packet appears to spread like a free particle, albeit more slowly. It is argued that, on some scales (lower than the Planck scale), this theory predicts significant deviation from conventional (linear) quantum mechanics. However, owing to the difficulty of controlling quantum coherence on one hand, and the weakness of gravity on the other, definitive experimental falsification poses a technologically formidable challenge.

  2. EU-project &apos;'GasHighWay'&apos; and utilization of biogas as a motor fuel; Das EU-Projekt &apos;GasHighWay&apos; und der Einsatz von Biogas als Kraftstoff

    Energy Technology Data Exchange (ETDEWEB)

    Haas, Andrea [Foerdergesellschaft fuer nachhaltige Biogas- und Bioenergienutzung (FnBB) e.V., Kirchberg/Jagst (Germany)

    2011-05-15

    The EU project &apos;GasHighWay&apos; is to enhance the use of natural gas and biogas as motor fuels. While Germany is the European leader in biogas production for heat and power generation, other European countries like Switzerland or Sweden are more advanced when it comes to using biogas as a motor fuel.

  3. Touching the &apos;'Pariah'&apos;. China&apos;s economic and strategic interests in the Caspian Crescent with special reference to Beijing&apos;s energy policy towards post-Pahlavi Iran

    Energy Technology Data Exchange (ETDEWEB)

    Weimar, Niclas D.

    2010-07-01

    The author of the contribution under consideration focuses on China&apos;s economic and strategic interests in the Caspian Crescent and the means by which the Peoples Republic of China seeks to enforce them. Most analysts, researches and Chinese officials rank the issue of the region&apos;s hydrocarbon resources equal to or even below other issues of interest such as border issues, regional stability and terrorism. But the facts previously stated raise questions about the particular role of energy in the overall context of China&apos;s interests in that region as well as the significance of Sino-Iranian relations for Beijing&apos;s regional goals. These goals give particular consideration to the Chinese government&apos;s blunt commitment to its ties with Pariah Indian despite pressure and criticism from the USA. Thereon, this study features three research objectives: (1) To outline China&apos;s economic and strategic interests in the Caspian Crescent and demonstrate they are dominated by Beijing&apos;s fundamental interest in oil and gas; (2) To demonstrate that Iran is China&apos;s key partner in the whole region around the Caspian Sea for the accomplishment of its interests in hydrocarbons and regional preponderance.

  4. Pythagoras&apos;s theorem on a two-dimensional lattice from a &apos;natural&apos; Dirac operator and Connes&apos;s distance formula

    Energy Technology Data Exchange (ETDEWEB)

    Dai Jian [Theory Group, Department of Physics, Peking University, Beijing (China)]. E-mail: jdai@mail.phy.pku.edu.cn; Song Xingchang [Theory Group, Department of Physics, Peking University, Beijing (China)]. E-mail: songxc@ibm320h.phy.pku.edu.cn

    2001-07-13

    One of the key ingredients of Connes&apos;s noncommutative geometry is a generalized Dirac operator which induces a metric (Connes&apos;s distance) on the pure state space. We generalize such a Dirac operator devised by Dimakis et al, whose Connes distance recovers the linear distance on an one-dimensional lattice, to the two-dimensional case. This Dirac operator has the local eigenvalue property and induces a Euclidean distance on this two-dimensional lattice, which is referred to as &apos;natural&apos;. This kind of Dirac operator can be easily generalized into any higher-dimensional lattices. (author)

  5. Initialization of the Euler model MODIS with field data from the &apos;&apos;EPRI plume model validation project&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, G.; Eppel, D.; Lautenschlager, M.; Mueller, A.

    1985-01-01

    The program deck MODIS (&apos;&apos;Moment DIstrubution&apos;&apos;) is designed to be used as operational tool for modelling the dispersion of a point source under general atmospheric conditions. The concentration distribution is determined by calculating its cross-wind moments on a vertical grid oriented in the main wind direction. The model contains a parametrization for horizontal and vertical diffusion coefficients based on a second order closure model. The Eulerian time scales, preliminarily determined by fitting measured plume cross sections, are confirmed by comparison with data from the EPRI plume model validation project. 8 refs., 9 figs.

  6. Hot air instead of electricity. Special modular pumps at &apos;&apos;Saunaparadies Erding&apos;&apos;; Heissluft statt Elektrowaerme. Modulare Sonderpumpen im Saunaparadies Erding

    Energy Technology Data Exchange (ETDEWEB)

    Christoph, D. [Grundfos GmbH, Erkrath (Germany)

    2008-07-01

    &apos;&apos;Saunaparadies Erding&apos;&apos; is a sauna spa with 16 newly constructed saunas and with an uncommon heating concept. The investor opted for hot air instead of electric heating. Accordingly, an industrial-scale boiler was installed in the mechanical equipment room. The boiler supplies air of 170 degC to the air-to-water heat exchangers in the sauna cabins. The design of this system was a great challenge to the planners and constructors and also to the components of the piping system. (orig.)

  7. The &apos;&apos;penumbra sign&apos;&apos; on T1-weighted MRI for differentiating musculoskeletal infection from tumour

    Energy Technology Data Exchange (ETDEWEB)

    McGuinness, B.; Wilson, N.; Doyle, A.J. [Middlemore Hospital, Department of Radiology, Masterton (New Zealand)

    2007-05-15

    The &apos;&apos;penumbra sign&apos;&apos; on unenhanced T1-weighted MR sequences is thought to be helpful for discriminating subacute osteomyelitis from bone neoplasm. We sought to quantify the sensitivity and specificity of this sign for bone and soft tissue infection in a general referral population. Clinical coding was used to identify patients admitted to Middlemore Hospital (Auckland, New Zealand) between January 2000 and November 2003 with a diagnosis of either infection or neoplasm of the upper or lower limb who had undergone an MRI scan. One hundred and eighty-three patients were included in the study. Fifty-seven patients had bone or soft tissue infection. One hundred and twenty-six had a bone or soft tissue neoplasm. Relevant unenhanced T1-weighted images were selected for each patient, randomised and placed in a folder on the Hospital PACS system. Four reviewers were shown the original article describing the penumbra sign and then asked to look at the images in the folder stating whether the penumbra sign was present or absent. The average specificity and sensitivity of the penumbra sign for musculoskeletal infection was 96% (range 94-99%) and 27% (range 21-34%) respectively. Interobserver reliability was moderate to good with an average kappa score of 0.57 (range 0.50-0.62). For isolated soft tissue infection there was a higher sensitivity (54%, 33-83%) but with similar specificity (98%, 96-100%) and interobserver reliability (0.47, 0.33-0.58). Of the 11 out of 57 (19%) true positive penumbra signs identified by a consensus of three or more of the observers, all were subacute, chronic or acute on chronic infections. The penumbra sign has a high specificity for musculoskeletal infection. This is also true for isolated soft tissue infection. The penumbra sign is helpful in differentiating neoplasm from infection and its presence in the setting of a high pretest probability is useful in making a diagnosis of infection. (orig.)

  8. Tratamento das fraturas do processo odontóide Treatment of odontoid fractures

    Directory of Open Access Journals (Sweden)

    Pedro Augusto Pontin

    2011-01-01

    Full Text Available OBJETIVO: Este artigo faz a avaliação retrospectiva clínica e radiológica das fraturas do odontóide de 20 pacientes atendidos no IOT-HCFMUSP, durante o período de 2004-2010. MÉTODOS: Foi realizado a estratificação destas fraturas segundo sua classificação (AO/Anderson e D'Alonzo, perfil epidemiológico, tipo de tratamento, tempo de consolidação e complicações. RESULTADOS: Observou-se maior número de casos da fratura do odontóide em pacientes do sexo masculino (4:1, com idade entre 3ª e 4ª década de vida (60%, vítimas de quedas de altura (60% e acidentes automobilísticos (25% como principais mecanismos de trauma, e 15% dos casos apresentaram-se com déficit neurológico. A fraturas do odontóide de maior prevalência foram as do tipo II (55%, seguidas pelas fraturas do tipo III (40%. Os tratamentos mais empregados nas fraturas do tipo II e III foram, respectivamente, o cirúrgico (73% e conservador (87,5%. A consolidação ocorreu em até 16 semanas para 87,5% dos casos de tratamento cirúrgico e para 54,5% dos tratados conservadoramente. Não houve casos de pseudoartrose. CONCLUSÃO: O tratamento cirúrgico das fraturas do odontóide do tipo II apresentou resultados satisfatórios em relação ao tempo consolidação e baixa incidência de complicações, bem como o tratamento conservador destinado às fraturas do tipo III.Nivel de Evidência IV, série de casos.OBJECTIVE: This article describes a clinical and radiologic retrospective analysis of odontoid fractures in20 patients accompanied byThe IOT-HCFMUSP,from 2004 to 2010. METHODS: These fractures were stratified according to their classification (AO/Anderson andD'Alonzo, epidemiologic profile, type of treatment, time to consolidation of the fracture, and complications. RESULTS: It was observed that there was a higher number of odontoid fractures in males (4:1, between the third and fourth decades of life (60%, and that the main causes of the trauma were falling from

  9. Stability of maxillary anterior crowding treatment Estabilidade do tratamento de apinhamento anterossuperior

    Directory of Open Access Journals (Sweden)

    Camila Leite Quaglio

    2012-08-01

    Full Text Available OBJECTIVE: To evaluate the stability and the relapse of maxillary anterior crowding treatment on cases with premolar extraction and evaluate the tendency of the teeth to return to their pretreatment position. METHODS: The experimental sample consisted of 70 patients of both sex with an initial Class I and Class II maloclusion and treated with first premolar extractions. The initial mean age was 13,08 years. Dental casts' measurements were obtained at three stages (pretreatment, posttreatment and posttreatment of 9 years on average and the variables assessed were Little Irregularity Index, maxillary arch length and intercanine. Pearson correlation coefficient was used to know if some studied variable would have influence on the crowding in the three stages (LII1, LII2, LII3 and in each linear displacement of the Little irregularity index (A, B, C, D, E in the initial and post-retention phases. RESULTS: The maxillary crowding relapse ( LII3-2 is influenced by the initial ( LII1, and the teeth tend to return to their pretreatment position. CONCLUSION: The results underline the attention that the orthodontist should be given to the maxillary anterior relapse, primarily on those teeth that are crowded before the treatment.OBJETIVO: avaliar a estabilidade e recidiva do tratamento de apinhamento dos dentes anterossuperiores em casos com extrações de pré-molares e avaliar a tendência dos dentes apinhados, no início do tratamento, a retornar à sua posição original. MÉTODOS: a amostra consistiu de 70 pacientes de ambos os sexos, com má oclusão inicial de Classe I e Classe II de Angle, tratados com extrações dos primeiros pré-molares. A idade média inicial foi de 13,08 anos. Foram avaliados os modelos de estudo nas fases inicial (T1, final (T2 e, em média, 9 anos pós-tratamento (T3 de cada paciente. As variáveis da arcada superior avaliadas e comparadas estatisticamente pela Análise de Variância (ANOVA foram: índice de irregularidade

  10. Hycanthone e oxamniquine no tratamento de crianças portadoras de S. mansoni

    Directory of Open Access Journals (Sweden)

    Maria Zelia Rouquayrol

    1976-04-01

    Full Text Available Os autores apresentam resultado de tratamento com Hycanthone e com Oxamniquine efetuado em grupos de 36 crianças de 6 - 15 anos de idade, portadoras de S. mansoni, mais um grupo Controle (não portadores, de igual número perfazendp o total de 108 crianças. Os grupos eram homogêneos quanto à idade, peso, altura, condições clínicas (forma intestinal moderada e fatores sócio-econômico-sanitários. Eram todos residentes no perímetro irrigado da Curú-Recuperação, Pentecoste-Ceará, e filhos de funcionários do DNOCS. Foi efetuado tratamento com Hycanthone (2,3 m/kg a 2,7 mg/kg mais placebo de Oxamniquine (Grupo A, com Oxamniquine (11,4 mg/kg a 20 mg/kg mais placebo de Hycanthone (Grupo B e placebo dos dois medicamentos para o grupo Controle (Grupo C. Foram realizados exames de sangue (hemograma, transaminases e fosfatases alcalinas, sumário de urina e coproscopias (Hoffman, Kato qualitativo e quantitativo. Após tratamento todos os casos ficaram sob observação durante 72 horas e mais seguimento clínico e laboratorial durante 4 meses. Efetuados teste de t e de chi-quadrado todos os resultados são apresentados em tabelas e assim sumariados: 1 Hycanthone mostrou eficácia completa apresentando 100% como índice de cura. 2 Oxamniquine apresentou índice de cura de 80%, sendo que os 7 pacientes não curados tiveram significativa redução do número de ovos viáveis; destes, após o 29 tratamento, persistiram apenas 3 eliminando ovos viáveis. 3 Efeitos colaterais do tratamento com Hycanthone foram os seguintes: dor local, febre, náuseas, vômitos, cefaléia, tontura e sonolência. 4 Oxamniquine quase não afetou as crianças do ponto de vista de efeitos colaterais demonstráveis, tendo apresentado alguns casos com febre moderada e transitória e um caso com queixa de náusea. 5 Testes de função hepática revelaram alterações leves com aumento de TGO tanto no Grupo Hycanthone como no Grupo Oxamniquine (sem diferença estat

  11. &apos;Lifecycle cost&apos; management used in ITER project

    International Nuclear Information System (INIS)

    &apos;Lifecycle cost&apos; management is a new kind of management. The International Nuclear Fusion Energy Program was managing by &apos;lifecycle cost&apos; method. The cost and other factors associated with cost were under control by the method. In the future, the system engineering method should be focused in engineering management, paying equal attention to both evaluation and management, and strengthening the application of information system in the cost management to effectively improve the management level. (authors)

  12. Why Was Kelvin&apos;s Estimate of the Earth&apos;s Age Wrong?

    Science.gov (United States)

    Lovatt, Ian; Syed, M. Qasim

    2014-01-01

    This is a companion to our previous paper in which we give a published example, based primarily on Perry&apos;s work, of a graph of ln "y" versus "t" when "y" is an exponential function of "t". This work led us to the idea that Lord Kelvin&apos;s (William Thomson&apos;s) estimate of the Earth&apos;s age was…

  13. Oxidative Stress Impairs Learning and Memory in apoE Knockout Mice

    OpenAIRE

    Evola, Marianne; Hall, Allyson; Wall, Trevor; Young, Alice; Grammas, Paula

    2010-01-01

    Cardiovascular risk factors, such as oxidative stress and elevated lipids, are linked to the development of cognitive impairment. A mediator common to both stressors is the apolipoprotein E (apoE). The objectives of this study are to determine the effects of apoE deficiency and diet-induced systemic oxidative stress in mice on vascular expression of inflammatory proteins and on cognitive function. Mice are placed on a diet enriched in homocysteine for fifteen weeks and then assessed for spati...

  14. Leucine supplementation via drinking water reduces atherosclerotic lesions in apoE null mice

    OpenAIRE

    Zhao, Yang; Dai, Xiao-Yan; Zhou, Zhou; Zhao, Ge-xin; Wang, Xian; Xu, Ming-Jiang

    2015-01-01

    Aim: Recent evidence suggests that the essential amino acid leucine may be involved in systemic cholesterol metabolism. In this study, we investigated the effects of leucine supplementation on the development of atherosclerosis in apoE null mice. Methods: ApoE null mice were fed with chow supplemented with leucine (1.5% w/v) in drinking water for 8 week. Aortic atherosclerotic lesions were examined using Oil Red O staining. Plasma lipoprotein-cholesterol levels were measured with fast protein...

  15. ESTUDO COMPARATIVO DO EFEITO FUNGICIDA DO ÓLEO COMERCIAL SAFETEAM E DO TRATAMENTO DE ULTRASSOM EM FLUIDOS DE CORTE

    Directory of Open Access Journals (Sweden)

    Rachele Marcon Nicoliello

    2016-08-01

    Full Text Available O setor de Usinagem utiliza fluidos de corte de base vegetal em suas máquinas-ferramenta por serem mais sustentáveis, porém sua composição química os torna mais susceptíveis à degradação. O principal objetivo deste trabalho foi avaliar dois tratamentos para o controle microbiológico em fluidos de corte: extrato vegetal Safeteam (tratamento químico e ultrassom (tratamento físico. De acordo com o histórico de degradação dos fluidos de corte do Centro de Competência em Manufatura (CCM e dados da literatura, identificou-se que o gênero Penicillium sp aparece com maior frequência. Para avaliar a eficiência dos tratamentos, utilizou-se fluido de corte de base vegetal (sem biocida e cepas de Penicillium oxalicum. No primeiro tratamento, utilizou-se a Concentração Mínima Inibitória (CMI de 5% do óleo comercial Safeteam, utilizando o método de profundidade. No segundo tratamento, com ultrassom, utilizou-se 100 mL de amostra de fluido de corte (90% de água e 10% de concentrado para cada parâmetro (variando 2 tempos e 3 potências. Como resultado, o extrato vegetal na CMI de 5% apresentou uma redução de 100% do número de Unidades Formadoras de Colônias (UFCs e o ultrassom uma redução significativa das UFCs, que não foi quantificada, já que, na leitura inicial, a quantidade de colônias foi incontável. Permitindo concluir que ambas as técnicas apresentaram resultados positivos para o controle do bolor Penicillium oxalicum em fluidos de corte.

  16. Contributions to the qualification of the &apos;'CRISTAL'&apos; criticality calculi scheme: interpretation of critical experiments. Elaboration of a characterization system of neutronic configurations; Contributions a la qualification du schema de calcul de criticite &apos;'cristal'&apos;: interpretation d&apos;experiences critiques. Elaboration d&apos;un systeme de caracterisation des configurations neutroniques

    Energy Technology Data Exchange (ETDEWEB)

    Gagnier, E

    1999-06-01

    This thesis work is about the validation of the new criticality-safety package CRISTAL and contributes to the modernization and the improvement of the computational tools. The first part presents neutronic elements, the objectives of safety criticality studies and the package CRISTAL. Then, the validation work concerned two series of experiments involving uranyl solutions (UO{sub 2}F{sub 2}) and UO{sub 2} powders. For these experiments, the differences between the computation results and the experimental results were analysed. It was highlighted interesting physical phenomena such of the compensations of errors between the approximate representation by the 99 energy group structure on the first resonance of oxygen and the anisotropy of the diffusion simulation as well as the influence of uranium 234 in high enriched solutions in uranium 235. Once the work of the experimental qualification carried out, raises the question of the use the base of qualification and the &apos;'calculation-experiment'&apos; variations which are referred to it. It is often difficult to establish the link between the &apos;&apos;studied configuration&apos;&apos; and the experiments of the base of qualification. The presented characterisation system proposes to answer in a way automatic and quantified this difficulty: - in bringing an answer on the package qualification for the studied configuration, - in giving an estimate of the package bias. To answer these points, it was defined a set of 35 characteristic neutronic parameters representing the behaviour of the medium. To process the information brought by these parameters and to use it to answer the objectives of the system, we called upon statistical methods (Principal Components Analysis and Sliced Inverse Regression). The results obtained in the feasibility studies showed the relevance of these methods for the considered objectives. (author)

  17. Teaching Laura Kipnis&apos;s "Love&apos;s Labors" in "Ways of Reading"

    Science.gov (United States)

    Fike, Matthew A.

    2013-01-01

    This essay describes a method of teaching a very challenging anthology piece: Laura Kipnis&apos;s "Love&apos;s Labors" (chapter 1 of her 2003 "Against Love: A Polemic"). The method, although designed for a critical thinking course, should also provide resources for those who teach Kipnis&apos;s work in writing courses. Using…

  18. Master&apos;s Degree Learners&apos; Use of Theory in Designing Instructional Materials

    Science.gov (United States)

    Wojtecki, John A.

    2012-01-01

    Educational institutions offering a master&apos;s degree program in instructional design incorporate instructional design theory into the master&apos;s degree course offerings. The responsibility for the student is to develop coursework. Master&apos;s degree learners will use instructional design theory to develop course materials. This study…

  19. Agreements for energy and environment; Patto per l&apos;energia e l&apos;ambiente

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    In this paper are reported in ambit of italian national conference of energy and environment, an agreement undersigned by deputy of political and social forces. [Italian] In questo documento e&apos; illustrato il patto per l&apos;energia e l&apos;ambiente cui hanno aderito forze sociali e politiche del paese.

  20. Primary Health Care Providers&apos; Knowledge Gaps on Parkinson&apos;s Disease

    Science.gov (United States)

    Thompson, Megan R.; Stone, Ramona F.; Ochs, V. Dan; Litvan, Irene

    2013-01-01

    In order to determine primary health care providers&apos; (PCPs) knowledge gaps on Parkinson&apos;s disease, data were collected before and after a one-hour continuing medical education (CME) lecture on early Parkinson&apos;s disease recognition and treatment from a sample of 104 PCPs participating at an annual meeting. The main outcome measure…

  1. Individual Differences in Children&apos;s and Parents&apos; Generic Language

    Science.gov (United States)

    Gelman, Susan A.; Ware, Elizabeth A.; Kleinberg, Felicia; Manczak, Erika M.; Stilwell, Sarah M.

    2014-01-01

    Generics ("&apos;Dogs&apos; bark") convey important information about categories and facilitate children&apos;s learning. Two studies with parents and their 2- or 4-year-old children (N = 104 dyads) examined whether individual differences in generic language use are as follows: (a) stable over time, contexts, and domains, and (b) linked…

  2. The Impact of Adolescents&apos; Dyslexia on Parents&apos; and Their Own Educational Expectations

    Science.gov (United States)

    Rimkute, Laura; Torppa, Minna; Eklund, Kenneth; Nurmi, Jari-Erik; Lyytinen, Heikki

    2014-01-01

    The present study examined the role that adolescents&apos; dyslexia plays in their educational expectations, as well as their parents&apos; expectations concerning their offspring&apos;s future education. To investigate this, 170 adolescents were asked to report their educational expectations on two occasions while they were still attending…

  3. James Baldwin&apos;s "Everybody&apos;s Protest Novel": Educating Our Responses to Racism

    Science.gov (United States)

    Frank, Jeff

    2014-01-01

    The aim of this article is to establish--and explore--James Baldwin&apos;s significance for educational theory. Through a close reading of "Everybody&apos;s Protest Novel", I show that Baldwin&apos;s thinking is an important (if unrecognized) precursor to the work of Stanley Cavell and Cora Diamond, and is relevant to a number of…

  4. White Teachers&apos; Racial Identities, Perceptions of Students&apos; Behaviors, and Symptoms of Burnout

    Science.gov (United States)

    Chen, Cynthia E.

    2013-01-01

    Educational research has examined factors contributing to teachers&apos; burnout symptoms, including their perceptions of student behaviors (Ingersoll, 2003). Interestingly, teacher and students&apos; races have been differentially related to teachers&apos; perceptions of student behavior (Downey & Pribesh, 2004); this disparity in perceptions…

  5. Tratamento farmacológico do transtorno de ansiedade generalizada: perspectivas futuras Pharmacological treatment of generalized anxiety disorder: future perspectives

    OpenAIRE

    Roberto Andreatini; Roseli Boerngen-Lacerda; Dirceu Zorzetto Filho

    2001-01-01

    O presente artigo apresenta uma visão atualizada e ampla do tratamento farmacológico do transtorno de ansiedade generalizada (TAG). São revistos os medicamentos com eficácia comprovada em estudos controlados e atualmente disponíveis na clínica (benzodiazepínicos, buspirona, antidepressivos, betabloqueadores, antipsicóticos e extrato de kava-kava). A seguir, baseados nesses dados, propõe-se um algoritmo de tratamento do TAG. São apresentadas as principais linhas de pesquisa de novos fármacos a...

  6. Anticonvulsivantes e antipsicóticos no tratamento do transtorno bipolar Anticonvulsants and antipsychotics in the treatment of Bipolar Disorder

    OpenAIRE

    Ricardo Alberto Moreno; Doris Hupfeld Moreno; Márcia Britto de Macedo Soares; Roberto Ratzke

    2004-01-01

    O transtorno bipolar é uma condição médica complexa e até o momento não há um tratamento único comprovadamente eficaz no controle de todos aspectos da doença. Foram revisadas a literatura disponível sobre o uso de anticonvulsivantes (valproato, carbamazepina, oxcarbazepina, lamotrigina, gabapentina, topiramato, clonazepam) e antipsicóticos atípicos (clozapina, risperidona, olanzapina, quetiapina, ziprasidona e aripiprazole) no tratamento agudo e profilático do transtorno bipolar. Existe um ac...

  7. Utilização de macrófitas aquáticas no tratamento de efluentes de suinicultura

    OpenAIRE

    Maia, Anabela; Catarino, Justina; Rodrigues, Fátima; Mendonça, E; Trancoso, Maria Ascensão

    2007-01-01

    Em contraste com anteriores abordagens, actualmente as tecnologias ambientais tendem a utilizar um menor consumo de recursos energéticos e materiais. No que respeita ao tratamento de efluentes a utilização de macrófitas aquáticas tem tido um interesse crescente revelando-se como um método simples e energicamente eficiente na remoção de nutrientes e contaminantes com aplicação no tratamento de efluentes urbanos, industriais e agrícolas. Este sistema baseia-se nas interações entre as plantas, e...

  8. Atelectasias em pediatria: mecanismos, diagnóstico e tratamento Atelectasis: mechanisms, diagnosis and treatment in the pediatric patient

    OpenAIRE

    Cíntia Johnston; Werther Brunow de Carvalho

    2008-01-01

    OBJETIVO: Realizar uma revisão da literatura sobre os mecanismos, diagnóstico e tratamento das atelectasias pulmonares em pediatria. MÉTODOS:Efetuou-se uma pesquisa nos bancos de dados eletrônicos Medline e Scielo com os critérios de inclusão: artigos publicados entre os anos de 1960 e 2007, que abordassem a etiologia, fisiopatologia, conseqüências funcionais, avaliação, prevenção, tratamento e complicações das atelectasias pulmonares em pediatria. Palavras-chave: atelectasis, children, pedia...

  9. Green economy. From theory to practice; &apos;Green Economy&apos;. Von der Theorie zur Praxis

    Energy Technology Data Exchange (ETDEWEB)

    Wackerbauer, Johann [ifo Institut, Muenchen (Germany)

    2013-04-15

    The topic of &apos;&apos;green economy&apos;&apos; took centre stage at last year&apos;s UN conference on sustainable development in Rio de Janeiro. The term &apos;&apos;green economy&apos;&apos; has many interpretations to it, ranging from an emphasis on energy and resource efficiency in an otherwise ordinary economy to positions that are critical of growth as such. What can be considered as the essence of the concept of green economy, and what challenges need to be mastered on the way there? The present study shows that there is more to the term than most companies and consumers are aware of.

  10. Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice

    NARCIS (Netherlands)

    Zerbi, V.; Wiesmann, M.; Emmerzaal, T.L.; Jansen, D.; Beek, M. van; Mutsaers, M.P.C.; Beckmann, C.F.; Heerschap, A.; Kiliaan, A.J.

    2014-01-01

    It is well established that the cholesterol-transporter apolipoprotein epsilon (APOE) genotype is associated with the risk of developing neuro-degenerative diseases. Recently, brain functional connectivity (FC) in apoE-epsilon 4 carriers has been investigated by means of resting-state fMRI, showing

  11. Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice

    NARCIS (Netherlands)

    Zerbi, V.; Wiesmann, M.; Emmerzaal, T.L.; Jansen, D.; Beek, M. van; Mutsaers, M.P.; Beckmann, C.F.; Heerschap, A.; Kiliaan, A.J.

    2014-01-01

    It is well established that the cholesterol-transporter apolipoprotein epsilon (APOE) genotype is associated with the risk of developing neurodegenerative diseases. Recently, brain functional connectivity (FC) in apoE-epsilon4 carriers has been investigated by means of resting-state fMRI, showing a

  12. Biodegradable loose fill packing material &apos;ECO-FOAM&apos;. Seibunkaisei barajo kanshozai &apos;ECO-FOAM&apos;

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    Biodegradable loose fill packing material &apos;ECO-FOAM&apos; was developed to prevent pollution of the natural environment after plastics have been used. The material uses a hybrid cornstarch of 95% or higher and a small amount of water-soluble synthetic additive(polyvinyl alcohol). The manufacturing method is patented by National And Chemical Corporation in the U.S.A. The material has nearly the same buffering performance as the conventional foaming polystyrene, can be used on the existing filling facilities, and is non-electrically chargeable. Its raw material causes no destruction of resources and forests as experienced in petroleum and lumbers, and requires no foaming material such as butane for swelling, but foams naturally by mechanical action and heat of an extruding machine. The material has biodegradability of full degradation type, and is friendly with the environment. It is non-poisoning and safe, but has some problem in water resistance. While the material may be treated in various ways after having been disposed of as refuse, it may be incinerated, filled, or utilized as compost. The material may be degraded by activated sludge generated from sewage treatment. 5 figs.

  13. CHEMICAL COMPOSITION OF COMET C/2007 N3 (LULIN): ANOTHER &apos;'ATYPICAL'&apos; COMET

    Energy Technology Data Exchange (ETDEWEB)

    Gibb, Erika L.; Sudholt, Emily [Department of Physics and Astronomy, University of Missouri-St. Louis, St. Louis, MO 63121 (United States); Bonev, Boncho P.; Villanueva, Geronimo; Radeva, Yana [Department of Physics, The Catholic University of America, Washington, DC 20064 (United States); DiSanti, Michael A.; Mumma, Michael J., E-mail: gibbe@umsl.edu [Goddard Center for Astrobiology, Solar System Exploration Division, NASA Goddard Space Flight Center, Code 690, Greenbelt, MD 20771 (United States)

    2012-05-10

    We measured the volatile chemical composition of comet C/2007 N3 (Lulin) on three dates from 2009 January 30 to February 1 using NIRSPEC, the high-resolution ({lambda}/{Delta}{lambda} Almost-Equal-To 25,000), long-slit echelle spectrograph at Keck 2. We sampled nine primary (parent) volatile species (H{sub 2}O, C{sub 2}H{sub 6}, CH{sub 3}OH, H{sub 2}CO, CH{sub 4}, HCN, C{sub 2}H{sub 2}, NH{sub 3}, CO) and two product species (OH* and NH{sub 2}). We also report upper limits for HDO and CH{sub 3}D. C/2007 N3 (Lulin) displayed an unusual composition when compared to other comets. Based on comets measured to date, CH{sub 4} and C{sub 2}H{sub 6} exhibited &apos;normal&apos; abundances relative to water, CO and HCN were only moderately depleted, C{sub 2}H{sub 2} and H{sub 2}CO were more severely depleted, and CH{sub 3}OH was significantly enriched. Comet C/2007 N3 (Lulin) is another important and unusual addition to the growing population of comets with measured parent volatile compositions, illustrating that these studies have not yet reached the level where new observations simply add another sample to a population with well-established statistics.

  14. Households&apos; recycling efforts

    Energy Technology Data Exchange (ETDEWEB)

    Bruvoll, Annegrete; Halvorsen, Bente [Research Department, Statistics Norway, 8131 Dep, N-0033 Oslo (Norway); Nyborg, Karine [The Ragnar Frisch Centre of Economic Research, Gaustadalleen 21, N-0349 Oslo (Norway)

    2002-11-01

    Households&apos; recycling effort is often argued to be of an insignificant size. It is also frequently argued that this contribution, if significant, is not a cost to households, since it is voluntary. Thus households&apos; use of time and energy are frequently disregarded in cost-benefit analyses of stricter recycling targets. In this survey, based on 1162 interviews, we find that sorting at source involves significant extra use of time and energy in the households. On average, each of those asked reported that they use close to half an hour a week for cleaning, sorting and transporting recyclable waste. On average, 185 h is used per tonne of waste. Four out of ten reported that they use warm or hot water to clean the materials. When investigating the motives for sorting waste, we find that many perceive sorting as mandatory, while some in fact find it a pleasant activity in itself. Moral motives for sorting at source are also widespread. A majority would prefer that a company took over the sorting if this were possible, and on average, the respondents are willing to pay US$ 20/year for this service.

  15. Apolipoprotein E (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?

    Science.gov (United States)

    Jasienska, Grazyna; Ellison, Peter T; Galbarczyk, Andrzej; Jasienski, Michal; Kalemba-Drozdz, Malgorzata; Kapiszewska, Maria; Nenko, Ilona; Thune, Inger; Ziomkiewicz, Anna

    2015-03-22

    The alleles that are detrimental to health, especially in older age, are thought to persist in populations because they also confer some benefits for individuals (through antagonistic pleiotropy). The ApoE4 allele at the ApoE locus, encoding apolipoprotein E (ApoE), significantly increases risk of poor health, and yet it is present in many populations at relatively high frequencies. Why has it not been replaced by natural selection with the health-beneficial ApoE3 allele? ApoE is a major supplier of cholesterol precursor for the production of ovarian oestrogen and progesterone, thus ApoE has been suggested as the potential candidate gene that may cause variation in reproductive performance. Our results support this hypothesis showing that in 117 regularly menstruating women those with genotypes with at least one ApoE4 allele had significantly higher levels of mean luteal progesterone (144.21 pmol l(-1)) than women with genotypes without ApoE4 (120.49 pmol l(-1)), which indicates higher potential fertility. The hormonal profiles were based on daily data for entire menstrual cycles. We suggest that the finding of higher progesterone in women with ApoE4 allele could provide first strong evidence for an evolutionary mechanism of maintaining the ancestral and health-worsening ApoE4 allele in human populations.

  16. Maglev technology - results and conclusions of Maglev&apos;2006; Magnetschwebetechnologie - Ergebnisse und Erkenntnisse von der MAGLEV&apos;2006

    Energy Technology Data Exchange (ETDEWEB)

    Schach, R.; Naumann, R. [Technische Univ. Dresden (Germany). Inst. fuer Baubetriebswesen

    2007-04-15

    From 13 to 15 September 2006, Germany acted as host for &apos;Maglev &apos;2006&apos; under the patronage of the German Federal Ministry of Transport, Building and Urban Development (BMVBS). This event also integrated the Dresden &apos;Fachtagung Transrapid&apos;, a specialist conference, which the Dresden University of Technology has now organized for the sixth time. (orig.)

  17. SKI&apos;s and SSI&apos;s review of SKB&apos;s safety report SR-Can

    Energy Technology Data Exchange (ETDEWEB)

    Dverstorp, Bjoern; Stroemberg, Bo (and others)

    2008-03-15

    This report summarises SKI&apos;s and SSI&apos;s joint review of the Swedish Nuclear Fuel and Waste Management Co&apos;s (SKB) safety report SR-Can (SKB TR-06-09). SR-Can is the first assessment of post-closure safety for a KBS-3 spent nuclear fuel repository at the candidate sites Forsmark and Laxemar, respectively. The analysis builds on data from the initial stage of SKB&apos;s surface-based site investigations and on data from full-scale manufacturing and testing of buffer and copper canisters. SR-Can can be regarded as a preliminary version of the safety report that will be required in connection with SKB&apos;s planned licence application for a final repository in late 2009. The main purpose of the authorities&apos; review is to provide feedback to SKB on their safety reporting as part of the pre-licensing consultation process. However, SR-Can is not part of the formal licensing process. In support of the authorities&apos; review three international peer review teams were set up to make independent reviews of SR-Can from three perspectives, namely integration of site data, representation of the engineered barriers and safety assessment methodology, respectively. Further, several external experts and consultants have been engaged to review detailed technical and scientific issues in SR-Can. The municipalities of Oesthammar and Oskarshamn where SKB is conducting site investigations, as well NGOs involved in SKB&apos;s programme, have been invited to provide their views on SR-Can as input to the authorities&apos; review. Finally, the authorities themselves, and with the help of consultants, have used independent models to reproduce part of SKB&apos;s calculations and to make complementary calculations. All supporting review documents are published in SKI&apos;s and SSI&apos;s report series. The main findings of the review are: -SKB&apos;s safety assessment methodology is overall in accordance with applicable regulations, but part of the methodology needs to be

  18. Reduction of NO{sub x} emissions from the combustion of hard coals &apos;'RENOX'&apos;; Reduccion de Emisiones de NO{sub x} en la combustion de Carbones Antracitosos &apos;'RENOX'&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    The present project, whose abbreviated name is RENOX, has the aim of reducing NO{sub x} emissions from the combustion of hard coals or coals with low volatile matter contents. It is applied to the combustion of these coals in arc boilers (or &apos;'U'&apos; boilers), where the necessary combination of long presence times and high hearth temperatures facilitates the high NO{sub x} levels reached. The intended reduction in emissions is approached through the application of primary combustion measures, also known as adjustment or refining of combustion. This solution is adopted for two reasons: due to its efficiency in environmental and economic terms, and because it is an unavoidable step if the levels to be attained require the installation of specific gas crubbing systems (secondary measures). The practical nature of RENOX has led to the development of the project in two phases, corresponding to two logical stages: phase 1, associated with the RNA project, on the characterization of emissions and combustion, complex numeric modelling of flows inside the boiler, and determination of the viability and scope of the optimization of emissions, and phase 2, the OPTINOXproject, which follows the methodology and lessons of the first phase and, as a natural continuation of this, deals with the design, development, manufacturing and validation of a computerized system that processes real time data on the boiler where it is installed to monitor, supervise and control the commercial operation of the plant, optimizing its combustion efficiency and/or NO{sub x} emissions. The practical objective of this project is represented by the construction of a validated prototype to demonstrate the OPTINOX system, which is capable of determining operating and control strategies that can minimize NO{sub x} emissions without unfavourably affecting the productivity and specific consumption of the units. Phase 1 development activities took place in groups 3, 4 and 5 of Compostilla

  19. Workshop &apos;&apos;actual data processing supported applications in the area of soil protection and contaminated sites&apos;&apos;; Workshop &apos;&apos;Aktuelle DV-gestuetzte Anwendungen im Bodenschutz- und Altlastenbereich&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Mathews, Jeannette; Frauenstein, Joerg; Mahrle, Sabine (comps.)

    2011-05-15

    Within the 5th workshop at the Federal Environment Agency (Dessau-Rosslau, Federal Republic of Germany) from 28th to 29th September, 2010, the following lectures were held: (1) Information systems for the contaminated site management in Baden-Wuerttemberg (I. Blankenhorn); (2) SALKA 7 - A web based solution for a central data handling of the Saxonian register of contaminated sites (S. Gruhne); (3) Information system (ABuDIS) for contaminated sites, soil conservation and disposal sites in the Free State of Bavaria - Experiences from the project &apos;Data quality&apos; (O. Klammer); (4) Environmental specimen bank - Web interface (M. Ruether); (5) Biocides in the Web - A portal for the publicity (G. Minx); (6) INSPIRE - Thematic work group (TWG) Appendix III Soil (S. Marahrens); (6) INSPIRE - State of the art, requirements (R. Baritz); (7) Requirements for the interoperability of soil data from the view of the Federal Environment Agency (F. Hilliges); (8) Implementation of the PortalU-Software in the European context - The project GS Soil (K. Feiden); (9) What is offered by PRTR - Pollutant Release and Transfer Register? (E. Six); (10) GSBL - Application for web recherche (B. Liebscher); (11) New Web Map Service for ground water background values (B. Wagner); (12) Visualized information on contaminated sites - A status (J. Frauenstein); (13) Utilization of industrial wastelands - An idea makes soil good. A project of BAFU for revitalization of industrial wastelands (K. Schenk); (14) Information on the status of ground water for the governmental real estates (H.-O. Zintz); (15) Application of data processing procedures of the artificial intelligence on an area-based representation of pollutant contents in settlement areas (T. Hertwig).

  20. Measure of the e+e-{yields}bb Cross Section at the LEP Energies; Medida de la seccion eficaz e&apos;'+e'&apos;-{yields}bb a las Energias de LEP

    Energy Technology Data Exchange (ETDEWEB)

    Arce Dubois, P.

    1992-07-01

    In the present work I analyse the data collected during 1990 by the L3 detector, situated in the electron-positron collider LEP. After selecting the events e&apos;'+e'&apos;-{yields} bb through their semileptonic decays into muons, I calculate the cross section for the process e&apos;'+e'&apos;- {yields} bb at different energy points around the mass of the vectorial boson Z, and I measure some parameters of the Standard Model, namely, the Br(b{yields}{mu} ),{gamma}{sub z}n-{yields}bb/{gamma}{sub z}n{yields}had and {gamma}{sub z}n{yields}bb{gamma}{sub z}n{yields}e&apos;'+e'&apos;-. (Author) 26 refs.

  1. May Goedel&apos;s Ideas Be Addressed Philosophically?

    Energy Technology Data Exchange (ETDEWEB)

    Dokulil, Milos [Department of Information Technologies, Faculty of Informatics, Masaryk University, Botanicka 68a, 602 00 Brno (Czech Republic)

    2007-11-15

    Goedel emphasised philosophy as an important tool in science. Much less is known about his religious background. We should bear in mind that our evaluational perspective differs very much from the one in which Goedel lived. He was personally sure that there must be another existence after death-an afterlife (&apos;of unlimited life span&apos;). As a &apos;Baptized Lutheran&apos; he did not include &apos;Trinity&apos; in his creed. He was also certain that mind is separate from matter. This text tries to include Libet&apos;s &apos;readiness potential&apos; into the debate concerning the specificity of the mind. Neither Goedel&apos;s identification of materialism with mechanism nor his vision of the &apos;spirit&apos; are a viable solution of the problem.

  2. Diferentes modalidades terapêuticas no tratamento da tendinopatia do supraespinhoso

    Directory of Open Access Journals (Sweden)

    Milton Faria Junior

    2013-06-01

    Full Text Available Objetivo: Verificar a eficácia de diferentes modalidades terapêuticas no tratamento da tendinopatia do supraespinhoso. Métodos: Ensaio clínico, de abordagem quantitativa e longitudinal, realizado de janeiro de 2010 a outubro de 2011 na Clínica de Fisioterapia da Universidade de Ribeirão Preto (UNAERP. Foram selecionados 24 pacientes adultos entre 40 e 50 anos, de ambos os gêneros, com diagnóstico de tendinopatia do supraespinhoso. Eles foram divididos em três grupos: Grupo 1 - ultrassom e cinesioterapia convencional; Grupo 2 - laser e cinesioterapia convencional; e Grupo 3 - cinesioterapia aprimorada. Como critérios de avaliação, foram utilizados os questionários de DASH e McGill e a avaliação da amplitude de movimento (ADM de flexão, extensão, abdução, adução, rotação interna (RI e rotação externa (RE. Na análise estatística, foi aplicado o Modelo de Regressão com Efeitos Mistos e o teste Kruskal-Wallis, através do software SAS® 9.0. Resultados: Após os tratamentos aplicados, os 3 grupos apresentaram melhora significativa da ADM (p<0,01 para os movimentos avaliados. O Grupo 1 apresentou ganho na ADM de RI (6° e diminuição do resultado do questionário DASH (-17,5. O Grupo 3 apresentou ganhos para os movimentos de flexão (22°, extensão (10°, abdução (26°, adução (11° e RE (13°, e uma diminuição do resultado do questionário McGill (-18,5. Conclusão: A cinesioterapia aprimorada, abordando todas as estruturas do ombro, mostrou-se mais eficaz no ganho de ADM quando comparada ao tratamento de eletroterapia e cinesioterapia convencional.

  3. TRATAMENTOS PRÉ-GERMINATIVOS EM SEMENTES DE Didymopanax morototoni (Aubl. Dcne. et Planch

    Directory of Open Access Journals (Sweden)

    Elci Terezinha Henz Franco

    2002-06-01

    Full Text Available Didymopanax morototoni (Aubl. Dcne. et Planch, (caixeta, é uma espécie nativa com vasta distribuição natural, rápido crescimento, grande porte e ainda pela sua rusticidade, é considerada uma espécie pioneira de potencial florestal para o Brasil. Porém, as suas sementes apresentam baixa germinabilidade. O objetivo deste trabalho foi avaliar o efeito de tratamentos pré-germinativos que pudessem maximizar o processo de germinação desta espécie. Foram testados os seguintes tratamentos: pré- -embebição em H20 por 8 h; escarificação química (HCl e H2SO4 a 70%; escarificação mecânica (por picotes no tegumento e com lixamento; lavagem com água destilada e lavagem em água + álcool (1:1 por 15, 30 e 45 min. As sementes foram colocadas para germinar em diferentes substratos. Realizou-se ainda teste de germinação in vitro. Sementes foram inoculadas em meio WPM, solidificado com ágar na presença de cinetina e ácido giberélico nas concentrações (0; 0,1; 0,5; 1,0 mg/l, e caseína hidrolisada na concentração 250 mg/l. A incubação foi a 25°C 1°C em câmara de germinação sob fotoperíodo de 16 horas luz, numa intensidade de 14,3 μE.m-².s-¹ ou no escuro. A germinação foi favorecida pelos pré-tratamentos de lavagens com água e água + álcool, sendo o tempo mais eficaz o de 45 min. A adição de cinetina e ácido giberélico provocou um aumento na germinabilidade de 40 a 70 %. Estes resultados confirmam a dormência tegumentar parcial e indicam a presença provável de substancias inibidoras nos tegumentos, removidas pelas lavagens.

  4. Cleptomania: características clínicas e tratamento Kleptomania: clinical characteristics and treatment

    Directory of Open Access Journals (Sweden)

    Jon E Grant

    2008-05-01

    Full Text Available OBJETIVOS: A cleptomania, um transtorno incapacitante do controle dos impulsos, caracteriza-se pelo furto repetitivo e incontrolável de itens que são de pequena utilidade para a pessoa acometida por esse transtorno. Apesar de seu histórico relativamente longo, a cleptomania continua sendo pouco entendida pelo público geral, pelos clínicos e pelos que dela sofrem. MÉTODO: Este artigo revisa a literatura sobre o que se sabe a respeito das características clínicas, histórico familiar, neurobiologia e opções de tratamento para indivíduos com cleptomania. RESULTADOS: A cleptomania geralmente tem seu início no final da adolescência ou no início da vida adulta, e parece ser mais comum em mulheres. A comorbidade psiquiátrica ao longo da vida com outros transtornos de controle de impulsos (20-46%, de uso de substâncias (23-50% e de humor (45-100% é freqüente. Indivíduos com cleptomania sofrem de prejuízo significativo em sua capacidade de funcionamento social e ocupacional. A cleptomania pode responder ao tratamento com terapia cognitivo-comportamental e com várias farmacoterapias (lítio, antiepilépticos e antagonistas de opióides. CONCLUSÕES: A cleptomania é um transtorno incapacitante que resulta em uma vergonha intensa, bem como problemas legais, sociais, familiares e ocupacionais. São necessários estudos de tratamento em ampla escala.OBJECTIVES: Kleptomania, a disabling impulse control disorder, is characterized by the repetitive and uncontrollable theft of items that are of little use to the afflicted person. Despite its relatively long history, kleptomania remains poorly understood to the general public, clinicians, and sufferers. METHOD: This article reviews the literature for what is known about the clinical characteristics, family history, neurobiology, and treatment options for individuals with kleptomania. RESULTS: Kleptomania generally has its onset in late adolescence or early adulthood and appears to be more

  5. Tratamento artroscópico do impacto femoroacetabular Arthroscopic treatment of femoroacetabular impingement

    Directory of Open Access Journals (Sweden)

    Giancarlo C. Polesello

    2009-06-01

    Full Text Available OBJETIVOS: O propósito deste estudo é avaliar os resultados em curto prazo do tratamento artroscópico do impacto femoroacetabular. A hipótese é a de que os resultados do tratamento artroscópico são favoráveis. MÉTODOS: Entre agosto de 2003 e agosto de 2007, 28 quadris foram submetidos ao tratamento do impacto femoroacetabular pela via artroscópica. A idade média dos pacientes foi de 34 anos, com média de seguimento de 27 meses. Quanto à melhora clínica, os pacientes foram avaliados pré e pósoperatoriamente pelo Harris Hip Score (HHS modificado por Byrd. Os pacientes foram avaliados pré e pós-operatoriamente em relação à rotação interna do quadril acometido. Os valores obtidos nos índices acima foram analisados estatisticamente através do método de Wilcoxon para a avaliação de variáveis não paramétricas. RESULTADOS: O Harris Hip Score médio pré-operatório foi de 54,2 e o pós-operatório, de 94,8 (p OBJECTIVE: The purpose of this study is to evaluate the short-term follow-up results of arthroscopic treatment of femoroacetabular impingement. Our hypothesis is that arthroscopic treatment results are favorable. METHODS: Between August 2003 and August 2007, 28 hips had femoroacetabular impingement treated by hip arthroscopy. The mean age was 34 years, with mean follow-up period of 27 months. Clinical results were graded with the modified Harris hip score, which was measured pre-and postoperatively. Patients had also their internal rotation analyzed. These parameters were calculated by using Wilcoxon's t test for analysis of nonparametric paired samples performed. RESULTS: The mean preoperative Harris Hip Score was 54.2, improving to 94.8 postoperatively (p<0,001. The mean increase was 37.5 points. We had 4 good results (15% and 24 excellent results (85%. Preoperatively, the patients had a mean internal rotation of 17º, and, postoperatively, 36º. The average internal rotation increase was 19º (p<0,001. CONCLUSIONS

  6. Atualização no tratamento profilático das enxaquecas

    Directory of Open Access Journals (Sweden)

    KRYMCHANTOWSKI ABOUCH VALENTY

    1999-01-01

    Full Text Available Dentre as cefaléias primárias, pacientes com migrânea ou enxaqueca são os que mais procuram assistência médica. A sua prevalência é estimada em 12% da população sendo mais comum em mulheres com média de 18 a 20%, de 6% nos homens e de 4 a 8% nas crianças. O impacto econômico na produtividade e lazer é significativo, e as crises incapacitam o paciente para as atividades habituais. Com fisiopatologia complexa e ainda insuficientemente conhecida, a migrânea pode cursar com ataques de cefaléia intermitente, intensa e com características peculiares. A abordagem mais eficiente para o tratamento inclui o afastamento dos fatores deflagradores, tratamento medicamentoso preventivo, uso de medicamentos de resgate para os momentos de dor, e as terapias acessórias ou não medicamentosas. Para o tratamento profilático, objeto desta avaliação, utilizam-se várias classes de medicamentos que incluem os beta bloqueadores, antidepressivos tricíclicos (e mais recentemente inibidores seletivos da recaptação da serotonina, antagonistas dos canais de cálcio, antagonistas da serotonina, anticonvulsivantes e outros. Embora os seus mecanismos de ação nas migrâneas ainda sejam desconhecidos, parece que todos atuam nas funções serotoninérgica, noradrenérgica e gabaérgica centrais. Novas propostas de mecanismos de ação para algumas destas drogas incluem a inibição da formação do óxido nítrico e a ação específica de modulação em canais catiônicos neuronais. Quando individualizados e usados corretamente, estes medicamentos preventivos têm sido responsáveis por reduções importantes na frequência e intensidade dos episódios de migrânea, diminuindo assim o sofrimento e condutas duvidosas às quais os pacientes são usualmente submetidos.

  7. O tratamento do pé artrogripótico Treatment of the arthrogrypotic foot

    Directory of Open Access Journals (Sweden)

    Simone Dota Simis

    2008-05-01

    Full Text Available A artrogripose é um termo utilizado para definir a presença, ao nascimento, de múltiplas contraturas articulares. A amioplasia é a principal e mais freqüente doença que cursa com contraturas congênitas e deformidade em eqüinovaro dos pés. A maioria dessas crianças tem bom potencial para a deambulação, havendo a necessidade da correção da deformidade dos pés para a posição plantígrada. O tratamento desses pés continua sendo um desafio devido à rigidez característica da doença e ao alto risco de recidiva. Os autores apresentam as opções de tratamento com base em uma revisão ampla da literatura, discutindo as técnicas cirúrgicas convencionais, como as liberações de partes moles e a talectomia, e a correção com o aparelho de Ilizarov. Ressaltam os estudos com resultados do tratamento primário do pé artrogripótico, na tentativa de fundamentar e auxiliar o ortopedista nesta difícil escolha.Arthrogryposis is the name used to define the presence of multiple joint contractures at birth. Amyoplasia is the main and most frequent among the diseases that take place with congenital contractures and equinovarus deformity of the foot. Most of these children have a good potential for walking, and a correction is required to correct their feet to the plantigrade position. Treatment of these feet presents a challenge due to the characteristic rigidity of the disease and to the high risk of recurrence. The authors present the treatment options based on a broad review of the literature, and discuss the conventional surgical techniques, such as the release of soft tissues and talectomy, and the correction of Ilizarov's device. They point to the studies that show the results of primary treatment of the arthrogrypotic foot in an attempt of providing a basis and giving a support to the orthopedist in this difficult choice.

  8. Tratamento de epilepsia: consenso dos especialistas brasileiros Treatment of epilepsy: consensus of the Brazilian specialists

    Directory of Open Access Journals (Sweden)

    Luiz Eduardo Betting

    2003-12-01

    Full Text Available Epilepsia é uma condição muito freqüente em todo o mundo. Na última década, várias opções terapêuticas surgiram ou foram aprimoradas. O principal método utilizado para decisão terapêutica baseia-se nos estudos randomizados, que representam o maior nível de evidência. Entretanto, mesmo estes estudos são passíveis de críticas e em alguns casos o tratamento de escolha permanece controverso. Nestas situações, a opinião dos especialistas, na área da epileptologia, com maior experiência clínica, passa a ter grande valor. O presente estudo tem como principal objetivo elaborar um consenso de tratamento das epilepsias, através da opinião de experts brasileiros no assunto. Este consenso poderá auxiliar na criação de manuais e estratégias para o tratamento de determinadas síndromes epilépticas, de acordo com os padrões socioeconômicos brasileiros.Epilepsy is a frequent condition in the world. Recently a study in Brazil showed prevalence of 18/1000 inhabitants in São José do Rio Preto, São Paulo State. In the last decade, new therapeutic options were discovered or developed. The main therapeutic decision method is based on randomized clinical trials. This method represents the higher level of evidence. However, even these studies have limitations and in some cases the treatment of choice remains controversial. In these instances, the epilepsy experts' opinions become helpful. In 2001 a similar study had been conducted in USA. The aim of this study is to create guidelines for epilepsy treatment based on the opinion of the Brazilian experts. These guidelines can be used to create manuals and strategies for the treatment of some epileptic syndromes according to Brazilian experts. As compared to the North-American guidelines our study better reflects the resources available in our country.

  9. KDYNA user&apos;s manual

    Energy Technology Data Exchange (ETDEWEB)

    Levatin, J.A.L.; Attia, A.V.; Hallquist, J.O.

    1990-09-28

    This report is a complete user&apos;s manual for KDYNA, the Earth Sciences version of DYNA2D. Because most features of DYNA2D have been retained in KDYNA much of this manual is identical to the DYNA2D user&apos;s manual.

  10. Japan&apos;s new energy policy

    International Nuclear Information System (INIS)

    Japan&apos;s energy policy is undergoing fundamental changes. The accident at TEPCO&apos;s Fukushima Daiichi nuclear power plant questions the future contribution of nuclear power in the national energy mix. Growing imports of fossil fuels to replace the lost nuclear capacity inflated energy prices and raise economic and energy security challenges. At the same time, the US shale gas and oil revolution is reshaping the global energy scene. Japan expects to take advantage of the trend to eliminate the &apos;Asian premium&apos; on natural gas prices and expand cheaper natural gas consumption. These developments have driven the Government of Japan to review its energy policy from scratch and adopt a new Strategic Energy Plan. This new policy has far reaching implications for gas and coal development in Japan but also for the international markets as Japan is the world&apos;s largest LNG importer and the second largest coal importer. This document summarizes the key findings of a new report by CEDIGAZ &apos;Japan&apos;s new energy policy: In search for stable and competitive energy supply&apos;. The report analyzes the current changes taking place on the gas and coal markets in Japan, in light of the new energy policy adopted in April 2014, and in particular the decision to restart safe nuclear power plants and push forward electricity market reforms

  11. Steady-State Confinement of Non-Neutral Plasmas Using Trivelpiece-Gould Modes Excited by a &apos;&apos;Rotating Wall&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    F. Anderegg; E.M. Hollmann; C.F. Driscoll

    1999-12-31

    A &apos;&apos;rotating wall&apos;&apos; voltage varying as exp(im{sub {theta}}{theta}+ ik{sub z}z - i2{pi}ft) can give steady-state confinement of more than 10{sup 9} charges in a Penning-Malmberg trap at 4 Tesla. For both pure ion plasmas and pure electron plasmas, the torque exerted on the plasma by the rotating wall exhibits peaks at the frequencies of k{sub z} {ne} 0 Trivelpiece-Gould modes. As expected, modes with f > m{sub {theta}}fr (i.e. propagating faster than the plasma rotation) give positive torque and cause plasma compression; and modes with f < m{sub {theta}}fr give adverse torque and cause plasma expansion. The rotating wall drive also causes plasma heating, but cyclotron radiation (in the electron case) and collisions with background residual neutral gas (in the ion case) keep the temperature low enough that background ionization is negligible. The rotating wall &apos;'slip'&apos; is typically greater for electrons than for ions, because f - m{sub {theta}}fr is proportional to the plasma frequency {omega}{sub p}. This contrasts with the k{sub z} = 0 rotating wall perturbation which couples to crystallized ion plasmas with no slip. By increasing the frequency of the rotating wall, we observed a plasma central density compression of about a factor of 20. These techniques may be useful for a variety of trapping experiments.

  12. Omani Students&apos; Definitions of Geography

    Science.gov (United States)

    Al-Nofli, Mohammed Abdullah

    2014-01-01

    Very few studies have been conducted on students&apos; definitions of geography. The purpose of the present study was to add to the existing literature by exploring Omani students&apos; definitions of geography. Participants were 477 students of grade 6 (ages 11-12) and grade 10 (ages 15-16) in one school district in Oman. They had been taught…

  13. Testing Bernoulli&apos;s Law

    Science.gov (United States)

    Ivanov, Dragia; Nikolov, Stefan; Petrova, Hristina

    2014-01-01

    In this paper we present three different methods for testing Bernoulli&apos;s law that are different from the standard "tube with varying cross-section." They are all applicable to high-school level physics education, with varying levels of theoretical and experimental complexity, depending on students&apos; skills, and may even be…

  14. Singapore&apos;s double festival

    International Nuclear Information System (INIS)

    Coinciding with celebrations for the nation&apos;s 25th anniversary, the 25th International Conference on High Energy Physics, held in Singapore from 2-8 August, was itself a double festival, with the Standard Model of contemporary physics and CERN&apos;s new LEP electron-positron collider providing the twin themes

  15. India&apos;s Higher Education Challenges

    Science.gov (United States)

    Altbach, Philip G.

    2014-01-01

    India, with the world&apos;s second largest higher education system and a rapidly growing economy as one of the BRIC nations, faces significant challenges in building both capacity and excellence in higher education. India&apos;s higher education system is characterized by "islands of excellence in a sea of mediocrity." The mainstream…

  16. Poland&apos;s syndrome: radiologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Bazzi Junior, Joao Lourenco, E-mail: joaobazzijr@gmail.com [Clinica Via Imagem, Xanxere, SC (Brazil); Matta, Eduardo Simoes da [Pro Circulacao - Clinica de Angiologia, Cirurgia Vascular e Ecografia Vascular, Xanxere, SC (Brazil); De Bortoli, Luciano [Materclinica Materno Infantil, Xanxere, SC (Brazil); De Bortoli, Felipe Raasch [Universidade Catolica de Pelotas (UCPel), Pelotas, RS (Brazil). Fac. of Medicine

    2012-05-15

    Poland&apos;s syndrome is a rare non-inherited congenital anomaly. The authors describe the classic radiologic findings of Poland&apos;s syndrome by reporting the case of a male four-year old patient with asymmetry of hands and chest, illustrating the fundamental imaging criteria for a conclusive diagnosis. (author)

  17. Universal machine &apos;'Shtrek'&apos; and the tractor-lifter with pneumatic-equipment control. [Auxiliary multipurpose materials handling equipment

    Energy Technology Data Exchange (ETDEWEB)

    Bal' bert, B.M.; Borumenskiy, V.A.; Lishenko, A.P.; Mitchenko, G.A.

    1982-01-01

    The machine &apos;'Shtrek'&apos; is described. It makes it possible to mechanize over 20 auxiliary operations: loading-unloading operations: extraction of old and deformed timbering; dissmantling of obstructions; erection of different types of timbering; making and restoring of drainage channels; laying and straightening of a drift and its leveling; assembly and disassembly of pipelines and mine equipment, etc. Depending on the type of operation, the machine has the corresponding suspended equipment. The elementary variant has a limited area of application at mines of the central region of the Dunbass. Currently a pneumatic variant of the machine &apos;'Shtrek'&apos; has been developed. The electric motor and the starter of the pumping equipment of the machine have been replaced by a pneumatic motor and pneumatically controlled valve KTM-50. In this case there was significant reduction in the weight of the pumping equipment and in its overall dimensions; the electric drive of the hydraulic distributors for controlling the mechanisms were replaced by simpler pneumatic ones; the logical circuit of the control system was constructed on the USEPPA elements. A specialized tractor-lifter designed for moving suspended loads is described for auxiliary operations in the near-face zone of the preparatory drifts. The machine also lifts and lowers the boom, rotates the boom by 270/sup 0/ and additionally lifts and lowers the weight-lifting hook.

  18. Final Report, NERI Project: &apos;&apos;An Innovative Reactor Analysis Methodology Based on a Quasidiffusion Nodal Core Model&apos;&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Dmitriy Y. Anistratov; Marvin L. Adams; Todd S. Palmer; Kord S. Smith; Kevin Clarno; Hikaru Hiruta; Razvan Nes

    2003-08-04

    OAK (B204) Final Report, NERI Project: &apos;&apos;An Innovative Reactor Analysis Methodology Based on a Quasidiffusion Nodal Core Model&apos;&apos; The present generation of reactor analysis methods uses few-group nodal diffusion approximations to calculate full-core eigenvalues and power distributions. The cross sections, diffusion coefficients, and discontinuity factors (collectively called &apos;&apos;group constants&apos;&apos;) in the nodal diffusion equations are parameterized as functions of many variables, ranging from the obvious (temperature, boron concentration, etc.) to the more obscure (spectral index, moderator temperature history, etc.). These group constants, and their variations as functions of the many variables, are calculated by assembly-level transport codes. The current methodology has two main weaknesses that this project addressed. The first weakness is the diffusion approximation in the full-core calculation; this can be significantly inaccurate at interfaces between different assemblies. This project used the nodal diffusion framework to implement nodal quasidiffusion equations, which can capture transport effects to an arbitrary degree of accuracy. The second weakness is in the parameterization of the group constants; current models do not always perform well, especially at interfaces between unlike assemblies. The project developed a theoretical foundation for parameterization and homogenization models and used that theory to devise improved models. The new models were extended to tabulate information that the nodal quasidiffusion equations can use to capture transport effects in full-core calculations.

  19. Workers&apos; Education in Palestine

    Science.gov (United States)

    Elayassa, Wajih

    2013-01-01

    Due to the political context and the restrictions placed on general freedoms and trade union activities, workers&apos; education in Palestine remained informal and largely reliant on oral memory until the early 1990s. For decades, it was an integral part of political education. Workers&apos; education only became a stand-alone field after the…

  20. A importância da família no tratamento do uso abusivo de drogas: uma revisão da literatura

    Directory of Open Access Journals (Sweden)

    Schenker Miriam

    2004-01-01

    Full Text Available Este artigo apresenta uma revisão da literatura sobre as duas fases do tratamento do adicto e de sua família: o engajamento e o tratamento propriamente ditos. Ressalta, através de diversos estudos, a necessidade do adicto ser atendido juntamente com a sua família para um resultado satisfatório do tratamento. Aponta para questões socioculturais importantes que interferem no tratamento realizado em Instituições. Enfatiza que o tratamento do adicto e de sua família contribui para o entendimento e as bases de uma ação efetiva de prevenção.

  1. Gene-Environment Interplay in the Link of Friends&apos; and Nonfriends&apos; Behaviors with Children&apos;s Social Reticence in a Competitive Situation

    Science.gov (United States)

    Guimond, Fanny-Alexandra; Brendgen, Mara; Vitaro, Frank; Forget-Dubois, Nadine; Dionne, Ginette; Tremblay, Richard E.; Boivin, Michel

    2014-01-01

    This study used a genetically informed design to assess the effects of friends&apos; and nonfriends&apos; reticent and dominant behaviors on children&apos;s observed social reticence in a competitive situation. Potential gene-environment correlations (rGE) and gene-environment interactions (GxE) in the link between (a) friends&apos; and…

  2. European Union&apos;s environmental strategy

    International Nuclear Information System (INIS)

    Environmental policy is an art of execution. Hence the fact that European Union member states have recently managed to agree on targets of emissions to fight climate change leaves open the question of how they will meet them. Economics cannot but embrace the scientific consensus on climate change and cannot say much about the efficiency of alternative technologies. Yet, its expertise is valuable to calculate economic effects and fairness of policies and to assess the relevance of incentives structures and effectiveness of institutions put into place to convert scientific consensus into action. This article is concerned with this latter point: does the EU have the right institutions to fight climate change? We claim that such is not the case, and offer to institute a &apos;European Community of Environment, Energy and Research&apos; to go forward. Initially published in &apos;Revue de l&apos;OFCE&apos; No. 102

  3. Initial increase, &apos;&apos;peaking effect&apos;&apos;, in the internal friction of copper following pulsed neutron and electron irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Simpson, H.M.; Parkin, D.M.; Goldstone, J.A.; Hemsky, J.W.

    1985-01-01

    Under certain experimental conditions the internal friction in metals can first increase and following prolonged irradiation decrease. Many models have been proposed to account for this &apos;&apos;peaking effect&apos;&apos;; however, in many of the cases, no effort is made to distinguish between the influence of interstitials and/or vacancies. To determine the nature of the point defect responsible for the peaking effect in high purity copper, we have performed a series of pulsed irradiations using neutrons and electrons. In all of the experiments an initial very rapid rise in the internal friction and Young&apos;s modulus was observed. These data show that a fast diffusing defect is responsible for the peaking effect: i.e. the interstitial.

  4. Review of the study &apos;&apos;Development of the energy markets - energy reference forecast&apos;&apos; from the perspective of brown coal

    International Nuclear Information System (INIS)

    In June 2014 the Federal Ministry for Economic Affairs and Energy (BMWi) published an expertise prepared by the EWI, GWS and Prognos institutes entitled &apos;&apos;Development of the energy markets - energy reference forecast&apos;&apos;. This study presents probable developments in the energy economy up to the year 2030 (reference forecast) on the assumption of a yet more stringent energy and climate protection policy as well as continuing impediments to its implementation. Complementing the forecast is an outlook up to the year 2050 (scenario of trends). But what do the findings of this expertise say about the future utilization of Germany&apos;s greatest domestic energy resource, namely brown coal? This question is addressed in the following article.

  5. Supplemental report on cost estimates&apos;

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1992-04-29

    The Office of Management and Budget (OMB) and the U.S. Army Corps of Engineers have completed an analysis of the Department of Energy&apos;s (DOE) Fiscal Year (FY) 1993 budget request for its Environmental Restoration and Waste Management (ERWM) program. The results were presented to an interagency review group (IAG) of senior-Administration officials for their consideration in the budget process. This analysis included evaluations of the underlying legal requirements and cost estimates on which the ERWM budget request was based. The major conclusions are contained in a separate report entitled, &apos;&apos;Interagency Review of the Department of Energy Environmental Restoration and Waste Management Program.&apos;&apos; This Corps supplemental report provides greater detail on the cost analysis.

  6. Short circuit - How our power supply became more expensive and got worse. A critical balance after eight years &apos;'deregulation'&apos; of the German Energy Economy; Kurzschluss - Wie unsere Stromversorgung teurer und schlechter wurde. Eine kritische Bilanz nach acht Jahren &apos;'Liberalisierung'&apos; der deutschen Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Leuschner, U.

    2007-07-01

    Since 16 years the author, a journalist, pursues the economical and political development of the German power economy. Many facts of this book prove: the impacting consequences as the clear scarcity of 1998 introduced deregulation, which has permitted 8 years long the discrimination of competitors and enabled in this way an exampleless concentration of market might (pt. 1); how supply reliability became worse and power and gas got more and more expensive (pt. 2); the complete insufficient practice of cartel agreements which is exchanged by administrative grid charges respectively &apos;&apos;incentive regulation&apos;&apos; (pt. 3); the relation between management and policy which has become still more distantless than in the epoche of membership books (pt. 4); the development of the German power economy from the beginning in the 19th century to the deregulation incl. the reorganization on the area of the former German Democratic republic. (GL) [German] Im ersten Teil des Buches (&apos;&apos;Stromwirtschaft im Umbruch&apos;&apos;) befasst sich Leuschner nun noch eingehender mit den politischen Hintergruenden der verfehlten Deregulierung. Er stellt fest, dass es die letzte Regierung unter Helmut Kohl war, die von Anfang an die Weichen falsch gestellt hat. Die Hauptverantwortung fuer die Nichtkorrektur des Fehlers und den fortgesetzten &apos;&apos;Schmusekurs mit den Konzernen&apos;&apos; sieht er aber bei den beiden folgenden rot-gruenen Bundesregierungen. Er verdeutlicht ferner, dass die erhoehten Belastungen durch Stromsteuer, EEG und KWK-Gesetz keine hinreichende Begruendung fuer den Strompreisanstieg liefern. Wo nicht minder wichtige Faktoren fuer den Preisanstieg liegen, veranschaulicht er im Kapitel ueber die &apos;&apos;Preisveredelung an der EEX&apos;&apos;. Im zweiten Teil, der die technischen Hintergruende und Risiken der Deregulierung behandelt, findet man jetzt auch ausfuehrlich die europaweite Netzstoerung beschrieben, die EON am 4. November 2006

  7. Fair Miles? The concept of &apos;food miles&apos; through a sustainable development lens

    Energy Technology Data Exchange (ETDEWEB)

    MacGregor, James; Vorley, Bill

    2006-10-15

    The concept of &apos;food miles&apos; presents an argument to buy goods which have travelled the shortest distance from farm to table, and to discriminate against long-haul transportation, especially air-freighted goods. The long-distance transport of food is associated with additional emissions due to increased transportation coupled with greater packaging, as well as a disconnection between the public and local farming. Furthermore, &apos;food miles&apos; encapsulates (and is at the vanguard of) the climate change debate in the UK. In light of growing international concern over the speed and scale of climate change, the concept of &apos;food miles&apos; has captured public attention and apparently is changing some consumers&apos; behaviour, although only around one-third of shoppers know of the concept.

  8. Kinetic characterization and of recrystallization of the aluminum alloy 6063 after S work hardening treatment; Caracterizacao e cinetica de recristalizacao da liga de aluminio 6063 apos tratamentos termomecanicos

    Energy Technology Data Exchange (ETDEWEB)

    Esposito, Iara Maria

    2006-07-01

    The aluminum 6063 alloy possesses a great industrial interest, presenting characteristics that justify its frequent use, when compared to the other aluminum alloys: the precipitation hardening and high cold work capacity. These alloys present high ductility, that allows their use in operations with high deformation degrees, as the cold work. The objective of this work is to show comparative analysis of the hardness Vickers of the commercial aluminum 6063 alloy, after cold work with different area reduction degree and thermal treatment. Considering the frequent utilization aluminium 6063 alloy, this work studies the characterization and recrystallization of this alloy, after the plastic deformation in different area reduction degrees, thermal treatment and convenient treatment times - Thermo mechanic Treatments. (author)

  9. Occupational doses in neuroendocrine tumors by using {sup 177}Lu DOTATATE; Doses ocupacionais em tratamento de tumores neuroendocrinos utilizando {sup 17&apos;}7Lu DOTATATE

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Gustavo Coelho Alves; Sa, Lidia Vasconcellos de, E-mail: gustavo@ird.gov.b, E-mail: lidia@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2011-10-26

    This paper investigated the treatment of neuroendocrine tumors (abdominal tumors) using of {sup 177}Lu DOTATATE radiopharmaceutical which is a type of treatment presently used in the experimental form in Brazil and, therefore, not contemplated in norms or specific use. This research studied the occupational doses of this treatment and suggested guidelines or rules of procedures viewing the radiological protection of workers involved and the public. The treatment were followed up by using two types of radiation detection, one a scintillator and a Geiger-Muller, and the measurements were performed in a public hospital at Rio de Janeiro and the other in a private hospital at Sao Paulo. It was observed that the equivalent occupational doses can variate from 160 {mu}Sv to 450 {mu}Sv, in function of operator, of stage of manipulation, and of the administration method, which can be through the use of infusion pump or manual injection. The use of infusion pump is highly recommended and the hospitalization of the patient until the dose rate measured at 1 m does not surpass 20 {mu}Sv/h

  10. Radio-Tracking Studies of Adult Chinook Salmon and Steelhead to Determine the Effect of &apos;'Zero'&apos; River Flow During Water Storage at Little Goose Dam on the Lower Snake River, Final Report of Research.

    Energy Technology Data Exchange (ETDEWEB)

    Liscom, Kenneth

    1985-09-01

    Allowable instantaneous minimum river flows are established in the Columbia and Snake Rivers to ensure safe passage of anadromous fish during their migration to the spawning grounds. However, water storage during periods of low power demands (at night and on weekends) would be beneficial to the power producers. This storage procedure is called &apos;'zero'&apos; river flow and is now permitted on a limited basis when there are few if any actively migrating anadromous fish present in the river system. Requests were made to extend &apos;'zero'&apos; river flow into periods when anadromous fish were actively migrating and a study was initiated. Radio-tracking studies were conducted on the Snake River between Lower Monumental and Little Goose Dams to determine the effect of &apos;'zero'&apos; river flow on the migration of adult chinook salmon, Oncorhynchus tshawytscha, and steelhead, Salmo gairdneri. From July through September, 1981, a total of 258 steelhead and 32 chinook salmon were radio-tagged. The rate of migration was used to determine differences between test and control fish and a gamma distribution model was used to describe the migration rate for radio-tagged fish. Estimates of the parameters of the model were used to statistically compare &apos;'zero'&apos; flow and normal river flow conditions for the radio-tagged fish. The results show that the &apos;'zero'&apos; flow condition delays the migration of adult chinook salmon and steelhead; therefore, extended periods of &apos;'zero'&apos; flow to store water are not recommended when fish are actively migrating in the river system. 16 refs., 5 figs., 9 tabs.

  11. Technical and quality requisites (RTC&apos;s) &apos;a data architecture&apos;; Requisitos tecnicos y de calidad (RTC&apos; s) &apos;una arquitectura de datos&apos;

    Energy Technology Data Exchange (ETDEWEB)

    Munoz G, R.; Jimenez R, B.; Ahedo A, S. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)]. e-mail: rmg@nuclear.inin.mx

    2007-07-01

    The RTC&apos;s are notes of technical and of quality requisites that the CLV emits, according to validity procedures of the Nuclear power station, to specify purchasing requisites of equipment with quality assurance category. This document contains a description of the computer program application RTC&apos;s, elaborated by the ININ for the CLV that allows to capture and to process the information of a database whose purpose is to facilitate the elaboration of the RTC&apos;s. Details of its development process are included. (Author)

  12. Germany steps up pressure on Fessenheim, but is the &apos;Energiewende&apos; all-knowing?

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Brighton (United Kingdom)

    2015-04-15

    Politics of course has more than its fair share of those who know everything and do their best not to let get the facts get in the way where inconvenient truths risk destroying their &apos;'Besserwisser'&apos; illusions. An example of this is a letter from Germany&apos;s federal environment minister Barbara Hendricks to her French counterpart Segolene Royal. The subject of the letter was the closure of France&apos;s Fessenheim nuclear power plant. The content of the letter appears to show that, not content with stamping out the use of nuclear energy in Germany and all the knowledge and industrial expertise that goes with it, Germany seems intent on imposing its point of view onto its neighbour. Hendricks acknowledges that any decisions relating to Fessenheim are for France alone as a sovereign nation. But, if that is the case, why bother to write the letter in the first place? In reply Royal, a prominent French Socialist, stresses French president Francois Hollande&apos;s desire to close Fessenheim before his term of office draws to a close. Royal also noted that it is up to France&apos;s nuclear operator, EDF, to &apos;&apos;define which reactors are removed from the grid&apos;&apos;. It is also amusing to read Royal&apos;s comment that the fact Fessenheim can be closed at all is largely due to the construction of replacement nuclear capacity at Flamanville, in northern France. Surely that irony could not have been lost on Germany&apos;s environment ministry.

  13. Florais de bach como terapia complementar no tratamento dos sintomas de DDAH

    Directory of Open Access Journals (Sweden)

    Hellen Karla Oliveira Marques

    2012-06-01

    Full Text Available Introdução: O artigo aborda os Florais de Bach como Terapia complementar no tratamento dos sintomas dodistúrbio de déficit de atenção e hiperatividade (DDAH ou transtorno de déficit de atenção e hiperatividade(TDAH, um problema de saúde mental comum em crianças, caracterizado por distração, inquietação,impulsividade e transtornos de aprendizagem. Se o quadro persiste até a fase adulta, o portador tem sua vidaprofissional e pessoal afetada. A realidade do transtorno em crianças no Estado de São Paulo é preocupante, asecretaria Municipal da saúde (SMS do estado comprou nos primeiros meses de 2011 uma quantidade igual aquase o total adquirido no em 2010 de comprimidos de Ritalina (Cloridrato de Metilfenidato, estimulante dosistema nervoso central usado no tratamento do transtorno. Reportagens relatam que DDAH está entre asdoenças que mais renderá lucros para a indústria farmacêutica em 2012. Método: O trabalho realizado porpesquisas em internet e buscadores como LILAC´S, Scielo, Medline, e Pubmed sobre estudos quantitativos daeficácia da Terapia Floral no tratamento dos sintomas das crianças portadoras de DDAH. Incentivar a produçãocientíficacom aplicação de Terapia Floral no tratamento das crianças em escolas e Unidades básicas de saúde.Resultados: Verificou?se que a maioria das abordagens são descritas em sites de Terapeutas Holísticosepsicopedagogia e são enumerados os tipos de florais com suas funções no equilíbrio emocional. A terapia floralconfigura entre outras terapias tais como massagem, yoga, meditação e tai?chi?chuan. Foram encontradosraríssimos artigos e antigos do ano de 2007 a 2009 sobre padrão de cuidado nas escolas. Conclusões: Osestudos quantitativos sobre o temasão escassos principalmente no Brasil, porém deram um passoimportantecom resultados significativos no comportamento de emoções das crianças. A combinação detratamentos pedagógicos e terapia floral demonstraram efic

  14. Novas perspetivas no tratamento farmacológico da diabetes tipo 2

    OpenAIRE

    Fernandes, Bruno Miguel Gomes

    2015-01-01

    Os inibidores dos co-transportadores de sódio e glicose do tipo 2 (SGLT2, sodium glucose co-transporter 2) constituem um novo grupo de fármacos disponível para o tratamento da diabetes tipo 2. Os SGLT2 são os principais transportadores envolvidos na reabsorção renal de glicose no tubo contornado proximal; a sua inibição origina glicosúria, resultando na diminuição dos níveis plasmáticos de glicose de uma forma independente da ação da insulina. Atualmente esta classe é constituída por três fár...

  15. Tratamento cirurgico do hidrocefalo em crianças: II - complicações

    OpenAIRE

    Benedicto Oscar Colli; Edwin Montague Starr; Nelson Martelli

    1981-01-01

    São analisadas as complicações observadas em 57 crianças hidrocéfalas submetidas a tratamento cirúrgico no período de 1970 a 1980. As causas de hidrocéfalo foram malformação congênita (42,1%), infecção meníngea (36,8%) e neoplasias (21,1%). Não foram observadas complicações nos casos submetidos à derivação externa do líquido cefalorraquídeo e a implantação de reservatório no couro cabeludo, em comunicação com o ventrículo lateral, apresentou várias complicações (abscesso subcutâneo, abscesso ...

  16. Fístula arteriovenosa coronário- pulmonar: tratamento cirúrgico

    OpenAIRE

    CÉSAR Cláudio Albernaz; ARAKAKI Nilo; BARBOSA Carlos Idelmar C.; Wilson FERREIRA JÚNIOR; COUTO Gustavo José Ventura; JAZBIK NETO João

    1997-01-01

    Fístulas arteriovenosas coronárias pertencem a um grupo de lesões cardíacas de difícil diagnóstico, por não apresentarem sintomas; quando suspeitadas de ocasionar o quadro clínico de um paciente, ou descobertas em exame de rotina, devem ser pesquisadas para o tratamento adequado. É relatado o caso de homem de 65 anos de idade, com história de precordialgia súbita, evoluindo para IAM de parede inferior, cuja investigação revelou a presença de fístulas de artérias coronárias direita e esquerda ...

  17. Tratamento preventivo da raiva humana Preventive treatment against rabies in humans

    Directory of Open Access Journals (Sweden)

    Murillo Pacca de Azevedo

    1981-10-01

    Full Text Available Foi elaborada Norma Técnica por uma Comissão constituída pelo Serviço Especial de Saúde Pública do Ministério da Saúde com a participação de represeentantes de vários estados brasileiros para que seja adotado, em todo o território nacional, um mesmo esquema de tratamento anti-rábico preventivo humano pós-exposição ao contágio.A technical note has been elaborated by a working-group coordinated by the "Serviço Especial de Saúde Pública" of the "Ministério da Saúde" with the participation of experts from various Brazilian States with a view to the adaptation, throughout Brazil, of the same technical norms for post-exposure anti-rabies preventive treatment.

  18. Tratamento de metástases hepáticas de carcinoma colo-rectal

    OpenAIRE

    Martins, Rui Miguel Rua Filipe

    2009-01-01

    O carcinoma colo-rectal é responsável por mais de 75% das metástases hepáticas, sendo a segunda maior causa de morte por doença neoplásica nos EUA. Aproximadamente 50% dos pacientes com carcinoma colo-rectal desenvolvem metástases hepáticas ao longo da evolução da doença. A ressecção hepática é o tratamento de eleição na metastização hepática de carcinoma colo-rectal, dado que permite um aumento da sobrevida aos 5 anos entre 26 a 49%, sendo a única opção terapêutica que pode levar à cura. A h...

  19. Aparelho Herbst: protocolos de tratamento precoce e tardio The Herbst appliance: early and late treatment protocol

    Directory of Open Access Journals (Sweden)

    Omar Gabriel da Silva Filho

    2005-02-01

    Full Text Available Até que ponto o crescimento mandibular pode ser realmente influenciado pelos aparelhos ortopédicos de reposicionamento anterior, ainda permanece indecifrável. Mas a lógica leva a crer que se existe alguma chance de potencializar o deslocamento anterior da mandíbula, ela será mais certa quando se utiliza aparelhos de avanço contínuo. O presente artigo discorre sobre os protocolos de tratamento precoce e tardio para a correção da deficiência mandibular com o aparelho Herbst.The question as to what extent mandibular growth may be influenced by orthopedic appliances remains unanswered. However, it seems reasonable to believe that the use of continuous forces potentialize the anterior displacement of the mandible. The current paper describes the early and late protocols of treatment of the mandibular deficiency with the Herbst appliance.

  20. Tratamento medicamentoso da osteoartrose do joelho Drug therapy in knee osteoarthrosis

    Directory of Open Access Journals (Sweden)

    Márcia Uchôa de Rezende

    2009-02-01

    Full Text Available O tratamento clínico da osteoartrite/artrose (OA está sempre indicado e baseia-se no autocuidado feito pelo paciente e orientado pelo médico. O uso de medicamentos é complementar às medidas de emagrecimento, ganho de força, de propriocepção, de flexibilidade e de amplitude de movimento. Entre os medicamentos disponíveis para o tratamento da OA há os que são essencialmente analgésicos e que não interferem no curso da doença; bem como os anti-inflamatórios, controversos por seus efeitos colaterais e pelo seu papel na OA, porém, com propriedades analgésicas e anti-inflamatórias indiscutíveis; e, por fim, as drogas modificadoras de estrutura, que retardam a evolução da OA. As medicações ainda podem ser de uso tópico, intra-articular, oral e injetável (sistêmico. As várias apresentações de ácido hialurônico (AH mostram o poder analgésico da droga e há indícios de poder modificador de estrutura da cartilagem pela medicação. Há nível de evidência IA, para diacereína e para a glucosamina, de que retardam a evolução da OA. Mais tecnologia para diagnóstico e controle de tratamento da OA, bem como mais estudos multicêntricos são necessários para consolidar o poder do tratamento medicamentoso de outras drogas.Clinical treatment for osteoarthritis (OA is very important and is based on patient's self care and guided by the physician. Drug therapy is additional to losing weight, improving muscular strength, proprioception, flexibility and range of motion. Between the available drugs for osteoarthritis' treatment, some are basically analgesics and do not interfere on disease's progression; some are anti-inflammatory with good analgesic power but with side effects that compromise their prolonged usage; and the structure modifying drugs that slow down the progression of OA. The medications are presented in topic, oral, intra-muscular, intra-venous and intra-articular forms. The hyaluronic acid has various

  1. Auto cuidado no tratamento pelo método de Ilizarov: um estudo de caso

    Directory of Open Access Journals (Sweden)

    Marisa Toshiko Ono Tashiro

    1995-03-01

    Full Text Available As autoras realizaram um estudo de caso com aplicação do modelo de auto cuidado de Dorothea Orem, no tratamento pelo método de Ilizarov, utilizando cuidados e orientações específicas para a recuperação e prevenção de complicações. A operacionalização do estudo constou de procedimentos relativos às demandasdecuida dos universais e terapêuticos, durante a hospitalização. As demandas foram detectadas no pré-operatório e os cuidados desenvolvidos no pós-operatório, facilitando ao paciente o aprendizado e a realização dos procedimentos necessários a dar continuidade dos mesmos no seu domicílio.

  2. Repercussões da radioterapia na região orofacial e seu tratamento

    OpenAIRE

    Ana Emília Holanda Rolim; Lino João da Costa; Luciana Maria Pedreira Ramalho

    2011-01-01

    A radioterapia em região de cabeça e pescoço provoca inúmeras sequelas ao paciente irradiado, afetando o sistema estomatognático e com repercussões sistêmicas importantes. As sequelas da radiação ionizante podem ser extensas e, algumas vezes, permanentes, em especial nas glândulas salivares e no tecido ósseo. É relevante que o cirurgião dentista tenha conhecimento das reações adversas e das formas adequadas de prevenção e tratamento para amenizar o desconforto e melhorar a condição de vida do...

  3. Comorbidade entre bulimia e transtorno de personalidade borderline: implicações para o tratamento

    Directory of Open Access Journals (Sweden)

    Bruno de Paula Rosa

    2011-06-01

    Full Text Available O estudo investiga o manejo clínico de pacientes com comorbidade entre transtorno alimentar e transtorno de personalidade borderline. Utilizou-se como estratégia metodológica o estudo de caso e o enfoque psicanalítico para análise dos dados. Após revisão teórica do tema, acompanha-se a evolução do tratamento por meio de vinhetas clínicas. Finalmente, postula-se o lugar do terapeuta como alguém que oferece um ambiente de confiança e acolhimento do sofrimento do paciente.

  4. Um caso de anorexia nervosa: a condução do tratamento

    Directory of Open Access Journals (Sweden)

    Alexandre Costa Val

    2014-09-01

    Full Text Available Descreve-se, neste texto, como o trabalho com sujeitos anoréxicos e bulímicos é conduzido pela equipe interdisciplinar do Núcleo de Investigação em Anorexia e Bulimia do Hospital das Clínicas da Universidade Federal de Minas Gerais (NIAB-HC/UFMG. Com base no referencial teórico e metodológico da psicanálise lacaniana, procede-se à construção do caso clínico, o que permite nortear a condução do tratamento em equipe. O trabalho de construção do caso clínico é apresentado a partir dos elementos singulares isolados ao longo do processo.

  5. Acupuntura como tratamento coadjuvante na síndrome talâmica: relato de caso

    Directory of Open Access Journals (Sweden)

    Alysson Bruno Oliveira Santos

    2011-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: As doenças cerebrovasculares são responsáveis por grande parte das mortes no mundo. Entre os sobreviventes, a maioria das sequelas limitantes encontradas nos pacientes é motora, mas quando vias ou centros sensitivos são afetados os pacientes podem evoluir com alterações de sensibilidade na região corpórea representada pela área encefálica atingida. Quando a região acometida relaciona-se com o tálamo pode ocorrer síndrome talâmica. O objetivo deste relato de caso foi demonstrar o uso da eletroacupuntura como coadjuvante no tratamento de dor central, diagnosticada como síndrome talâmica de difícil controle com tratamento farmacológico. RELATO DO CASO: Paciente do sexo feminino, 46 anos, com história de acidente vascular encefálico isquêmico que acometeu região temporoparietal esquerda em abril de 2003, evoluiu com hemiparesia e hemitaxia à direita. Após um ano, iniciou-se quadro doloroso insidioso, contínuo, difuso em hemicorpo direito, acompanhado de alodínea e hiperalgesia, diagnosticado como síndrome talâmica. Em janeiro de 2006, deu entrada no serviço de terapia da dor e medicina paliativa da Santa Casa de Misericórdia de São Paulo e iniciou tratamento farmacológico com resposta ruim, sendo programada para abordagem neurofuncional. Em julho de 2009, propôs-se à paciente tratamento com eletroacupuntura na tentativa de melhor controle de quadro álgico. Foram realizadas sessões de eletroacupuntura em pontos em couro cabeludo e membros. Após a décima primeira sessão, a paciente encontrava-se com quadro álgico controlado, sem uso de opioides e amitriptilina tópica, sensação de bem-estar elevada, maior coordenação motora, diminuição global da dor, sendo completa em mão e face. CONCLUSÕES: A eficácia da eletroacupuntura no controle do quadro álgico e no aumento do bem-estar encontra-se em concordância com estudos modernos, os quais demonstraram ativação de vias

  6. Rituximabe para o tratamento da artrite reumatoide: revisão sistemática

    Directory of Open Access Journals (Sweden)

    Lívia Lovato Pires de Lemos

    2014-06-01

    Full Text Available Introdução: A artrite reumatoide (AR é uma doença autoimune crônica caracterizada por inflamação articular sistêmica que, com frequência, leva a significativa incapacitação. Vários agentes anti-TNF têm sido usados efetivamente, mas alguns pacientes demonstraram resposta inadequada. Rituximabe é um anticorpo monoclonal terapêutico indicado em tais casos. Métodos: Realizou-se uma revisão sistemática para avaliar a eficácia e a segurança de rituximabe em pacientes com AR ativa previamente tratados ou não com agentes anti-TNF e para relacionar o desfecho com a sorologia para FR e anti-CCP. Pesquisaram-se importantes bancos de dados eletrônicos e a literatura não convencional, além de se fazer uma busca manual de referências. Para a meta-análise, utilizou-se o programa Review Manager® 5.1. Resultados: Consideramos seis ERCs comparando rituximabe 1000 mg com placebo. Em ambos os grupos usou-se Metotrexato. O tratamento com rituximabe foi mais efetivo em pacientes jamais tratados e nos que não obtiveram sucesso com a terapia anti-TNF - critérios ACR 20/50/70 e EULAR. No grupo de rituximabe, observaram-se mudanças menos expressivas nos escores de Sharp/Genant, de erosão e de estreitamento do espaço articular; nesse grupo, os escores SF-36, FACIT-T e HAQ-DI também foram melhores. Não foram notadas diferenças entre grupos com relação aos desfechos de segurança, com exceção das reações agudas à infusão, que foram mais comuns no grupo de rituximabe. Ainda no grupo de rituximabe, um número maior de pacientes soropositivos para FR/anti-CCP alcançou ACR20, em comparação com pacientes negativos para RF/anti-CCP. Conclusão: Os dados disponíveis falam em favor do uso de rituximabe para o tratamento da AR, como opção efetiva e segura para pacientes jamais tratados ou que não obtiveram sucesso com o tratamento anti-TNF. FR e anti-CCP parecem influenciar os resultados do tratamento, mas essa inferência ainda est

  7. Íleo pós-cirúrgico equino e o seu tratamento

    OpenAIRE

    Falcão, Slavador de Noronha de Alarcão

    2008-01-01

    Dissertação de Mestrado Integrado em Medicina Veterinária Com este estudo pretendeu-se fazer uma revisão acerca das causas e do que se sabe da fisiopatologia do íleo pós-cirúrgico equino e as suas possíveis opções de tratamento. Este estudo foi baseado na revisão bibliográfica de artigos científicos e completada com um caso clínico observado durante o estágio na universidade de Gent. O objectivo deste trabalho foi fazer uma revisão da anatomia e fisiologia do tracto gastrointestinal equ...

  8. Fraturas: origem e tratamentos - doi: 10.5102/ucs.v3i2.561

    Directory of Open Access Journals (Sweden)

    Gustavo Rocha Velloso

    2008-04-01

    Full Text Available As fraturas representam uma fadiga de estrutura óssea. O estudo dos conceitos básicos sobre a organização do tecido ósseo, o mecanismo indutor das fraturas e o processo de consolidação são temas importantes da moderna traumatologia. Alterações estruturais nos ossos ocorrem em decorrência de complexo sistema de forças deformadoras. As lesões podem ocasionar alterações em diferentes tecidos ósseos. O tratamento das fraturas é usualmente realizado pela fixação interna e externa, mas experimentos modernos apontam para que o processo biológico de reparação das fraturas seja melhor do que a fixação metálica.

  9. &apos;Micromorph&apos; solar cells; &apos;Mikromorphe&apos; Solarzellen, basierend auf amorphem und mikrokristallinem Silizium

    Energy Technology Data Exchange (ETDEWEB)

    Shah, A.

    2000-07-01

    This report on behalf of the Swiss Federal Office of Energy (SFOE) describes the achievements made in a project carried out at the Institute of Microelectronics (IMT) in Neuchatel, Switzerland. The project, whose goal was to demonstrate the potential of tandem cells consisting of a combination of micro-crystalline and amorphous solar cells, has spawned world-wide interest and also initiated much research into the use of VHF-GD (Very High Frequency Glow-discharge) techniques to deposit thin films. Individual results achieved at IMT including those from investigations into micro-crystalline structures and textures and their absorption enhancement effects, electronic transport, improvement of open-circuit voltage, deposition rates, patterning techniques and increasing stabilised efficiencies are listed. A first Micromorph 23.6 cm{sup 2} mini-module using an integrated electric series connection concept is mentioned and advances in the IMT&apos;s infrastructure and facilities are described.

  10. Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein

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    Ioannis Papaioannou

    2012-01-01

    Full Text Available Cardiovascular disease is the leading worldwide cause of death. Apolipoprotein E (ApoE is a 34-kDa circulating glycoprotein, secreted by the liver and macrophages with pleiotropic antiatherogenic functions and hence a candidate to treat hypercholesterolaemia and atherosclerosis. Here, we describe atheroprotective properties of ApoE, though also potential proatherogenic actions, and the prevalence of dysfunctional isoforms, outline conventional gene transfer strategies, and then focus on gene correction therapeutics that can repair defective APOE alleles. In particular, we discuss the possibility and potential benefit of applying in combination two technical advances to repair aberrant APOE genes: (i an engineered endonuclease to introduce a double-strand break (DSB in exon 4, which contains the common, but dysfunctional, ε2 and ε4 alleles; (ii an efficient and selectable template for homologous recombination (HR repair, namely, an adeno-associated viral (AAV vector, which harbours wild-type APOE sequence. This technology is applicable ex vivo, for example to target haematopoietic or induced pluripotent stem cells, and also for in vivo hepatic gene targeting. It is to be hoped that such emerging technology will eventually translate to patient therapy to reduce CVD risk.

  11. Tratamento cirúrgico e terapias adjuvantes na papilomatose respiratória

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    Melissa Ameloti Gomes Avelino

    2013-10-01

    Full Text Available Papilomatose respiratória recorrente ou papilomatose laríngea recorrente é uma doença da laringe, causada pelo papiloma vírus humano, caracterizada por lesões epiteliais verrucosas e, geralmente, recorrentes. Na literatura são descritos diversos tipos de tratamento, como cirurgia a frio, a laser e/ou uso de microdebridador, além das terapias adjuvantes; todas no sentindo de diminuir possíveis sequelas permanentes da doença. OBJETIVO: Realizar uma revisão de literatura a respeito desta doença com ênfase nas técnicas cirúrgicas e terapias adjuvantes mais utilizadas atualmente. MÉTODO: Utilizou-se a metodologia de revisão bibliográfica, por meio de levantamentos em base de dados eletrônicos de domínio público, entre 1992-2012, utilizando-se as palavras-chave: papiloma, infecções por papillomavírus, laringe, terapêutica, vacinas contra papillomavírus. RESULTADOS: Foram levantados 357 artigos, dos quais 49 foram usados como base para esta revisão. Os trabalhos científicos apontam para a redução de recidiva na maioria das terapêuticas adjuvantes. Entretanto, o levantamento demonstrou metodologias e amostras diferentes, o que não permitiu comparar os tipos de tratamento e de terapias adjuvantes. CONCLUSÃO: A escolha da técnica cirúrgica varia entre os autores, porém, há uma tendência atual ao uso do microdebridador. As terapias adjuvantes recentes, como cidofovir, vacina tetravalente contra o papiloma vírus humano e bevacizumab, necessitam de estudos mais amplos.

  12. Tratamento da superdosagem de anticoagulantes orais Reversal of excessive oral anticoagulation

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    Dayse Maria Lourenço

    1998-01-01

    Full Text Available OBJETIVO: Verificar a resposta de 73 pacientes com superdosagem de droga anti-vitamina K (AVK a 3 esquemas de tratamento. MÉTODOS: Os 73 pacientes foram avaliados em 94 ocasiões e divididos em 3 grupos: grupo A (N=32 , suspensão do AVK por 2 dias e introdução de dose menor; grupo B (N=37, suspensão do AVK e reavaliação em 4 dias; grupo C (N=25, vitamina K por via oral. A razão normalizada internacional (RNI final foi considerada adequada quando entre 2,0 e 4,0. RESULTADOS: Não houve diferença entre os tratamentos (chi²=2,352, p=0,671 para 61 pacientes com RNI inicial 8. Cinco dos 7 pacientes do grupo B que continuaram com superdosagem tinham RNI PURPOSE: To evaluate the response of 73 patients with antivitamin K (AVK overdose to 3 different therapeutic regimens. METHODS: Seventy three patients were evaluated in 94 occasions: group A (N=32, consisted of drug withdrawal for 2 days followed by reduced dosage; group B (N=37, drug withdrawal and reassessment within 4 days; group C (N=25, oral administration of vitamin K. Therapeutic range was set between INR-values of 2 and 4. RESULTS: Reversal regimens did not result in differences among 61 patients who had initial INR 4, but 5 of them were bellow 4.5, without increased bleeding risk. There were 10 patients in group C bellow therapeutic range, 6 of them with INR < 1.6, with risk of thromboembolism. Thirteen patients bled, but none required transfusion. CONCLUSION: Reversal of excessive oral anticoagulation can be safely performed by initial withdrawal of the drug, followed by lower doses. Vitamin K administration may lead to INR bellow the therapeutic range. This should be reserved for patients with high INR or in the presence of bleeding.

  13. Tratamento paliativo do adenocarcinoma gástrico Palliative treatment of gastric adenocarcinoma

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    Fernando de Oliveira Souza

    2011-03-01

    Full Text Available INTRODUÇÃO: Embora decrescendo nos países do chamado primeiro mundo, o adenocarcinoma gástrico mantém-se como terceiro tumor mais frequente no sexo masculino mundialmente. Sua mortalidade é muito elevada, fruto do diagnóstico tardio em lesões muito avançadas, o que frequentemente torna paliativo seu tratamento, motivos pelos quais se justificam estudos no sentido de melhorar estes resultados. MÉTODO: Revisão da literatura através do portal de periódicos da CAPES indicados por busca no sites da Bireme e PubMed. Além disso, foram consultados os sumários do 8º Congresso Internacional de Câncer Gástrico em 2009. Foi apresentada uma sugestão de algoritmo de atendimento destes pacientes. CONCLUSÕES: O surgimento de novas drogas anticancer, mais efetivas, está propiciando novas alternativas para a ressecção gástrica como tratamento paliativo. Novos protocolos estão surgindo mostrando boas perspectivas para melhorar os resultados desta doença.INTRODUCTION: Although decreasing in the well developed countries, gastric adenocarcinoma still represents the third most common cancer in males worldwide. Its mortality is very high because of the lateness of its diagnosis over advanced lesions, which turns palliative its treatment in the majority of the cases. METHOD: Literature review using CAPES, PubMed and Bireme sites as well as the abstracts of the 8 º International Gastric Cancer Congress which was held in Krakow in 2009. CONCLUSIONS: The release of new anticancer drugs against gastric cancer is providing a revival of gastrectomy as an effective palliative treatment of advanced gastric cancer. New protocols are being published, showing better results in the treatment of this disease.

  14. Efeito de diferentes tratamentos pré-congelamento sobre a qualidade do morango var. Chandler congelado

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    BERBARI Shirley Aparecida Garcia

    1998-01-01

    Full Text Available A adequabilidade da variedade de morango Chandler ao processo de congelamento e a influência da utilização de tratamentos pré-congelamento foram avaliadas. Tanto na matéria-prima como no produto final foram realizadas medidas objetivas de textura, pH, acidez total titulável, teor de sólidos solúveis, teor de ácido ascórbico e perda de líquido por exsudação. Subjetivamente foram avaliados o sabor, a textura e a cor do produto final. O preparo dos frutos para congelamento compreendeu os procedimentos normais de limpeza, corte em metades e os tratamentos de pré-congelamento, que utilizaram: sacarose, cloreto de cálcio, pectina e aplicação de calor. Os produtos foram acondicionados em latas com capacidade para 450g (74,6 x 95,2mm, revestidas internamente com verniz epóxi fenólico, que foram recravadas e em seguida congeladas a -25°C. O produto final foi armazenado por 45 dias a -18°C e avaliado após 12h de descongelamento em temperatura de 5°C. Os resultados mostraram que a variedade Chandler apresenta características adequadas ao congelamento e que a adição de cálcio e pectina é útil a este tipo de processamento, colaborando para a diminuição da perda de líquido por exsudação, assim como redução de perdas de ácido ascórbico e não interferindo no sabor e na cor do produto.

  15. Influência de tratamento térmico e sistemas de embalagens na qualidade de lichia 'Bengal

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    Valéria Delgado de Almeida Anjos

    2014-12-01

    Full Text Available Estudaram-se oito tratamentos quanto à eficiência de banhos hidrotérmicos com ou sem adição de produtos químicos na conservação da qualidade de lichias acondicionadas em bandejas de PET com tampa (BT e cobertas com filme de PVC de 15 µm (BF, sendo submetidas a banhos hidrotérmicos, tais como:T1-BT e T2-BF - sem tratamento; T3-BT- água a 55ºC por 20 s; T4-BF- água a 55ºC por 20 s; T5-BT- água a 55ºC por 10 s e em ácido cítrico 60% por 10 s; T6-BF- água a 55ºC por 10 s e banho de ácido cítrico 60% por 10 s ; T7-BT- ácido cítrico 60% por 20 s; T8-BF-ácido cítrico 60% por 20 s. Avaliaram-se as principais alterações físicas, químicas, sensoriais e presença de doença em lichias armazenadas a 4ºC e a 25ºC. De forma geral, ao final do estudo, as lichias ficaram ligeiramente menos ácidas, com leve aumento no pH e com discreta redução de sólidos solúveis, e após dois dias a 25ºC todos os tratamentos apresentaram infestação por fungos.Os tratamentos T5, T6, T7 e T8 foram considerados inaceitáveis (>4 a partir de 15 dias; T1, T2, T3 e T4 aceitáveis até 21 dias, pela avaliação visual. Quanto à manutenção da cor vermelha, os melhores tratamentos foram T1 e T4. O tratamento T2 apresentou os maiores valores de firmeza da casca, mostrando que o filme de PVC protegeu contra a perda de firmeza, de umidade e ao murchamento. A menor perda de massa foi nos tratamentos T6 e T8 (0,4%, ambos com filme de PVC, e a maior perda de massa foi nas amostras T5 (5,6% acondicionadas nas bandejas perfuradas, além de apresentar menor firmeza na casca.

  16. Tratamentos farmacológicos para o transtorno de ansiedade social: existem novos parâmetros na atualidade?

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    Larissa Forni dos Santos

    2011-01-01

    Full Text Available CONTEXTO: O transtorno de ansiedade social (TAS, apesar da baixa taxa de detecção e do alto índice de comorbidades associadas, é considerado uma condição tratável. Apesar da resposta estabelecida a diversas classes de medicamentos, os algoritmos para o tratamento do TAS necessitam de atualização constante. OBJETIVO: Realizar revisão sistemática da literatura no que diz respeito à eficácia dos tratamentos farmacológicos relativos ao TAS, a partir de estudos controlados, conduzidos no período de 2005 a 2010. MÉTODO: Foram utilizados os indexadores eletrônicos PsycoInfo, Lilacs e Medline, utilizando-se as palavras-chave: "social phobia or social anxiety and treatment". RESULTADOS: De acordo com critérios de inclusão adotados, 29 artigos foram incluídos e analisados. Mostram-se eficazes para o tratamento do TAS as seguintes drogas, de acordo com a classe: a ISRSs: escitalopram, fluvoxamina, citalopram, GR205171 e sertralina; b ISRSN: venlafaxina; c IMAOs: fenelzina, moclobemina; d aminoácidos: d-cicloserina; f anticonvulsivantes: tiagabina. CONCLUSÃO: Os ISRSs e os ISRSNs têm seu uso estabelecido e ainda continuam sendo considerados primeira opção de tratamento. Porém, destaca-se o potencial futuro da d-cicloserina e dos anticonvulsivantes, com necessidade de um número maior de estudos controlados que confirmem os achado iniciais. A ação das diferentes drogas em nível neurobiológico, bem como dos tratamentos associados, necessita ainda ser mais explorada.

  17. Fraturas do côndilo mandibular: classificação e tratamento Mandibular condylar fractures: classification and treatment

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    Luiz C. Manganello

    2002-10-01

    Full Text Available As fraturas do côndilo mandibular, dentre as fraturas faciais, são as que apresentam o maior número de controvérsias quanto ao seu tratamento e maior dificuldade de diagnóstico. A escolha de um tratamento - cirúrgico, bloqueio maxilo-mandibular, fisioterapia elástica ou associação -, está diretamente ligado ao tipo de fratura, à idade do paciente e ao grau de alteração funcional em decorrência da fratura. Os exames por imagens são importantes para o diagnóstico e classificação da fratura, no entanto, os achados clínicos são mais relevantes na indicação de um tratamento cirúrgico ou conservador. Este trabalho tem como objetivo apresentar uma classificação das fraturas do côndilo relacionada com o seu tratamento e relatar dois casos clínicos, sendo um tratado de forma cirúrgica e o outro conservadoramente, discutindo as vantagens e desvantagens do tratamento cirúrgico, bem como as indicações e contra-indicações.Condylar fractures are considered one of the most controversial fractures in face regarding treatment and diagnostic difficulty. Choosing the best treatment, such as surgery, inter maxillary fixation, physiotherapy or their association is directly related to fractures type, patient age and functional impairment degree. Clinical findings are relevant for proper diagnostic but image is fundamental for a precise treatment indication. We present a novel classification based on the condyle deviation and also propose a treatment for each type of fracture regarding age and clinical symptoms. We illustrate this paper with a description of two cases, one submitted to surgical and other to clinical treatment.

  18. Uso de tratamento hidrotérmico e ácido clorídrico na qualidade de lichia 'Bengal'

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    Ellen Toews Doll Hojo

    2011-06-01

    Full Text Available Um dos maiores problemas na pós-colheita da lichia é o escurecimento do pericarpo, cuja cor vermelha se torna totalmente escurecida em 48 horas, sob 25 ºC. Tecnologias que possam controlar o escurecimento do pericarpo são valiosas, e é o foco principal da pesquisa na área de pós-colheita. O objetivo deste trabalho foi avaliar a vida útil de lichias 'Bengal', armazenadas a 20 ºC e 82 %UR após o tratamento hidrotérmico e/ou imersão em solução de HCl. O delineamento experimental foi o inteiramente casualizado, em esquema fatorial 4 x 7, com 3 repetições, onde o primeiro fator correspondeu aos tratamentos: testemunha; imersão em HCl a 1%, por 6 minutos; tratamento hidrotérmico, com imersão em água a 52 ºC por 1 minuto, seguido de resfriamento em água a 10 ºC, por 6 minutos; e tratamento hidrotérmico, seguido de resfriamento em HCl a 1%, a 10 ºC, por 6 minutos. O segundo fator foram os períodos de armazenamento: 0; 1; 2; 3;6; 9 e 12 dias. A combinação entre tratamento hidrotérmico (52 ºC por 1 minuto e resfriamento em HCl a 1% permite conservar a coloração das lichias 'Bengal' por até dois dias. Mesmo assim há escurecimento em 25% da superfície.

  19. Qualidade fisiológica e tratamentos de sementes de cedrela fissilis procedentes do sul do Brasil

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    Marília Lazarotto

    2013-04-01

    Full Text Available Os objetivos deste trabalho foram: avaliar a qualidade fisiológica de sementes de cedro (Cedrela fissilis, procedentes de localidades do sul do Brasil, através de testes de vigor e avaliar diferentes tratamentos nas sementes para controle de patógenos e para promoção da germinação da espécie. Para tanto, foram utilizadas seis amostras com procedências dos Estados do Rio Grande do Sul, Santa Catarina e Paraná, as quais foram submetidas à determinação de teor de água, teste de germinação e primeira contagem, envelhecimento acelerado (testando períodos de exposição às condições de envelhecimento, emergência em viveiro e tratamento de sementes. Os tratamentos utilizados para controle de patógenos foram: testemunha (T0; físico com calor seco a 70°C±3°C por 48 horas (T1; extrato aquoso de alho (Allium sativum (T2; biológico à base de Trichoderma spp. - Agrotich Plus® (T3; e químico com fungicida protetor Captan (T4. A germinação variou de 56 a 87%; o período de 48 h sob temperatura de 41 °C foi o mais eficiente para estratificar as amostras em níveis de vigor; a emergência variou de 51 a 88% e as variáveis de desempenho de plântulas analisadas conseguiram estratificar as amostras em níveis de vigor. Quanto ao tratamento de sementes, o calor seco e o tratamento à base de extrato de alho se mostram eficientes no controle de microrganismos em semente de cedro, sem prejuízos ao vigor destas.

  20. Revisão sistemática sobre tratamentos psicológicos para problemas relacionados ao crack

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    Viviane Samoel Rodrigues

    2013-09-01

    Full Text Available OBJETIVO: O objetivo deste artigo é apresentar uma revisão sistemática da literatura sobre tratamentos psicológicos oferecidos para usuários de crack. MÉTODOS: Foi realizada uma revisão sistemática por meio de uma busca na literatura internacional e nacional, indexada nas bases de dados Medline, SciELO, Lilacs e Web of Science. Os descritores utilizados foram: crack or crack cocaine or cocaine smokers (crack and psychosocial treatment or psycotherapy or psychosocial treatment (tratamento psicológico e a busca incluiu artigos publicados no período de 2001 a 2011. RESULTADOS: No total foram encontrados 155 artigos por meio dos descritores utilizados. Os artigos foram agrupados em três dimensões: tratamentos psicossociais na internação e cuidados continuados, relaxamento respiratório e outras técnicas comportamentais e abordagens fundamentadas na Entrevista Motivacional, Cognitivo-Comportamental e Modelo Transteórico de Mudança. CONCLUSÃO: Com base nos estudos examinados, pode ser formulado um elenco de algumas intervenções que estão sendo estudadas para o tratamento de usuários de crack e algumas apresentam resultados satisfatórios. Os poucos esforços de comparação entre técnicas resultaram em evidências de pouca ou nenhuma diferença, ainda que se registre o benefício para os usuários na aplicação de qualquer delas. Não existe consenso acerca da efetividade no tratamento de usuários de crack. Parece oportuno e necessário o aprofundamento dos estudos nesse campo.