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Sample records for apoptosis key players

  1. Serine racemase: a key player in apoptosis and necrosis

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    Nadia eCanu

    2014-04-01

    Full Text Available A fine balance between cell survival and cell death is required to sculpt the nervous system during development. However, an excess of cell death can occur following trauma, exposure to neurotoxins or alcohol, and some developmental and neurodegenerative diseases, such as Alzheimer’s disease (AD. N-Methyl-D-aspartate receptors (NMDARs support synaptic plasticity and survival of many neuronal populations whereas inappropriate activation may promote various forms of cell death, apoptosis and necrosis representing the two extremes of a continuum of cell death processes both in vitro and in vivo. Hence, by identifying the switches controlling pro-survival vs. apoptosis and apoptosis vs. pro-excitotoxic outcome of NMDAR stimulation, NMDAR modulators could be developed that selectively block the cell death enhancing pro-survival signaling or synaptic plasticity mediated by NMDAR. Among these modulators, a role is emerging for the enzyme serine racemase (SR that synthesizes D-serine, a key co-agonist with glutamate at NMDAR. This review summarizes the experimental evidence from in vitro neuronal cultures -- with special emphasis on cerebellar granule neurons (CGNs -- and in vivo models of neurodegeneration, where the dual role of the SR/D-serine pathway as a master regulator of apoptosis and the apoptosis-necrosis shift will be discussed.

  2. Key Distribution based on Three Player Quantum Games

    CERN Document Server

    Toyota, Norihito

    2010-01-01

    We study a new QKD that is different from the scheme proposed by \\cite{Ramz2}, though it essentially takes our ground on three-player quantum games and Greenberg-Horne-Zeilinger triplet entangled state (GHZ state) \\cite{Gree} is used. In our scheme proposed in this article, Bob and Charlie (and Alice also) that they are players in a game get some common key or information (applied strategies and their payoffs in the game) by knowing some results of the measurement made by Alice. There is not any arbiter in our scheme, since existence of an arbiter increase the risk of wiretapping. For it is difficult to detect wiretapping, when an arbiter repeatedly sends classical information. Lastly we discuss robustness for eavesdrop. We show that though maximally entangled case and non-entangled case provided essentially equivalent way in QKD, the latter is not available in the case there are some eavesdroppers.

  3. DMPD: TLR3 in antiviral immunity: key player or bystander? [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16027039 TLR3 in antiviral immunity: key player or bystander? Schroder M, Bowie AG.... Trends Immunol. 2005 Sep;26(9):462-8. (.png) (.svg) (.html) (.csml) Show TLR3 in antiviral immunity: key pl...ayer or bystander? PubmedID 16027039 Title TLR3 in antiviral immunity: key player or bystander? Authors Schr

  4. Mast cells as key players in periodontal disease

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    Popovici Ramona Amina

    2014-01-01

    Full Text Available Mast cell (MC active mediators promote inflammation through changes induced in the connective tissue components of human gingiva. The aim of this study was to evaluate the distribution, mast cell density and their relationship with the degree of inflammatory infiltrate in gingiva from patients with periodontal disease. Thirty-nine cases with periodontal disease and 12 cases without significant changes to the gingival mucosa were investigated. MCs were identified on paraffin-embedded specimens by immunohistochemistry using anti-mast cell tryptase. The inflammatory infiltrate was scored from 0 to 3, and the MCs were counted using the hotspot method. Intraepithelial MCs were scored from 0 to 2. We found a significant increase of mast cell density in cases with mild and moderate inflammatory changes, and a slight decrease in patients with severe periodontal disease. We noticed a higher degranulation rate in patients with periodontal disease compared to those with healthy mucosa. Intraepithelial MCs were found in cases with periodontal disease only and were correlated with the severity of the inflammatory lesion. MCs are important cellular components of the early stages of periodontal disease. Contrary to other studies, we found that MC density and activation increases with moderate inflammation but decreases in severe inflammatory lesions. Our data suggest that MCs are key players in the progression of inflammatory lesions of the gingiva. In advanced-stage periodontal disease, intraepithelial MCs apparently play an important role, although their biological significance remains to be fully understood.

  5. Polyphenols as Key Players for the Antileukaemic Effects of Propolis

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    Murtala B. Abubakar

    2014-01-01

    Full Text Available Propolis (a bee product which has a long history of medicinal use by humans has attracted a great deal of research interest in the recent time; this is due to its widely reported biological activities such as antiviral, antifungal, antibacterial, anti-inflammatory, antioxidant, and anticarcinogenic properties. Crude form of propolis and its phenolic contents have both been reported to exhibit antileukaemic effects in various leukaemia cell lines. The ability of the polyphenols found in propolis to arrest cell cycle and induce apoptosis and differentiation in addition to inhibition of cell growth and proliferation makes them promising antileukaemic agents, and hence, they are believed to be a key to the antileukaemic effects of propolis in different types of leukaemia. This paper reviews the molecular bases of antileukaemic activity of both crude propolis and individual polyphenols on various leukaemia cell lines, and it indicates that propolis has the potential to be used in both treatment and prevention of leukaemia. This however needs further evaluation by in vitro, in vivo, and epidemiological studies as well as clinical trials.

  6. Polyphenols as key players for the antileukaemic effects of propolis.

    Science.gov (United States)

    Abubakar, Murtala B; Abdullah, Wan Zaidah; Sulaiman, Siti Amrah; Ang, Boon Suen

    2014-01-01

    Propolis (a bee product) which has a long history of medicinal use by humans has attracted a great deal of research interest in the recent time; this is due to its widely reported biological activities such as antiviral, antifungal, antibacterial, anti-inflammatory, antioxidant, and anticarcinogenic properties. Crude form of propolis and its phenolic contents have both been reported to exhibit antileukaemic effects in various leukaemia cell lines. The ability of the polyphenols found in propolis to arrest cell cycle and induce apoptosis and differentiation in addition to inhibition of cell growth and proliferation makes them promising antileukaemic agents, and hence, they are believed to be a key to the antileukaemic effects of propolis in different types of leukaemia. This paper reviews the molecular bases of antileukaemic activity of both crude propolis and individual polyphenols on various leukaemia cell lines, and it indicates that propolis has the potential to be used in both treatment and prevention of leukaemia. This however needs further evaluation by in vitro, in vivo, and epidemiological studies as well as clinical trials.

  7. Who are the key players in a new translational research network?

    OpenAIRE

    Long, Janet C; Cunningham, Frances C.; Carswell, Peter; Braithwaite, Jeffrey

    2013-01-01

    Background Professional networks are used increasingly in health care to bring together members from different sites and professions to work collaboratively. Key players within these networks are known to affect network function through their central or brokerage position and are therefore of interest to those who seek to optimise network efficiency. However, their identity may not be apparent. This study using social network analysis to ask: (1) Who are the key players of a new translational...

  8. Key role of mitochondria in apoptosis of lymphocytes.

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    Boichuk, S V; Minnebaev, M M; Mustafin, I G

    2001-12-01

    Changes in the mitochondrial potential, expression of phosphatidylserine, parameters of direct and lateral light scattering, and DNA fragmentation during spontaneous and induced apoptosis in peripheral blood lymphocytes were studied by flow cytofluorometry. Dexamethasone and Ca2+ ionophore A23187 served as inductors of apoptosis. A decrease in the mitochondrial potential is an early sign of spontaneous and induced apoptosis. Phosphatidylserine expression on the outer plasma membrane occurred later and inversely depended on the mitochondrial potential. Our results indicate that the involvement of mitochondria in spontaneous and induced apoptosis accompanied by a decrease in the mitochondrial potential is an early and key event of programmed lymphocyte death. The decrease in the mitochondrial potential of lymphocytes induced degradation of their nuclei (DNA fragmentation) and promoted elimination of apoptotic cells (phosphatidylserine expression).

  9. Clusterin: a key player in cancer chemoresistance and its inhibition

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    Koltai T

    2014-03-01

    Full Text Available Tomas Koltai Gerencia de Efectores Sanitarios Propios, Instituto Nacional de la Seguridad Social para Jubilados y Pensionados, Buenos Aires, República Argentina Abstract: Clusterin is a heterodimeric disulfide-linked glycoprotein (449 amino acids isolated in the rat prostate after castration. It is widely distributed in different tissues and highly conserved in species. There are two isoforms (1 and 2 with antagonistic actions regarding apoptosis. Clusterin is implicated in a number of biological processes, including lipid transport, membrane recycling, cell adhesion, programmed cell death, and complement cascade, representing a truly multifunctional protein. Isoform 2 is overexpressed under cellular stress conditions and protects cells from apoptosis by impeding Bax actions on the mitochondrial membrane and exerts other protumor activities, like phosphatidylinositol 3-kinase/protein kinase B pathway activation, modulation of extracellular signal-regulated kinase 1/2 signaling and matrix metallopeptidase-9 expression, increased angiogenesis, modulation of the nuclear factor kappa B pathway, among others. Its overexpression should be considered as a nonspecific cellular response to a wide variety of tissue insults like cytotoxic chemotherapy, radiation, excess of free oxygen radicals, androgen or estrogen deprivation, etc. A review of the recent literature strongly suggests potential roles for custirsen in particular, and proapoptosis treatments in general, as novel modalities in cancer management. Inhibition of clusterin is known to increase the cytotoxic effects of chemotherapeutic agents, and custirsen, a second-generation antisense oligonucleotide that blocks clusterin, is being tested in a Phase III clinical trial after successful results were achieved in Phase II studies. A major issue in cancer evolution that remains unanswered is whether clusterin represents a driving force of tumorigenesis or a late phenomenon after chemotherapy. This

  10. Purposeful Activity in Psychiatric Rehabilitation: Is Neurogenesis a Key Player?

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    Joyce Siu-Chong Cheung

    2016-06-01

    Full Text Available Adult neurogenesis, defined as the generation of new neurons in adulthood, has been a fascinating discovery in neuroscience, as the continuously replenishing neuronal population provides a new perspective to understand neuroplasticity. Besides maintaining normal physiological function, neurogenesis also plays a key role in pathophysiology and symptomatology for psychiatric conditions. In the past decades, extensive effort has been spent on the understanding of the functional significance of neurogenesis in psychiatric conditions, mechanisms of pharmacological treatment, and discovery of novel drug candidates for different conditions. In a clinical situation, however, long-term rehabilitation treatment, in which occupational therapy is the key discipline, is a valuable, economical, and commonly used treatment alternative to psychotropic medications. Surprisingly, comparatively few studies have investigated the biological and neurogenic effects of different psychiatric rehabilitative treatments. To address the possible linkage between psychiatric rehabilitation and neurogenesis, this review discusses the role of neurogenesis in schizophrenia, major depression, and anxiety disorders. The review also discusses the potential neurogenic effect of currently used psychiatric rehabilitation treatments. With a better understanding of the biological effect of psychiatric rehabilitation methods and future translational studies, it is hoped that the therapeutic effect of psychiatric rehabilitation methods could be explained with a novel perspective. Furthermore, this knowledge will benefit future formulation of treatment methods, especially purposeful activities in occupational therapy, for the treatment of psychiatric disorders.

  11. Key players and activities across the ERP life cycle: A temporal perspective

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    2007-01-01

    Full Text Available Enterprise Resource Planning (ERP systems are enterprise wide systems that, because of their integration, automate all of a company's business processes. They have rapidly become the de facto industry standard for replacement of legacy systems. In this paper I analyze using an information theory approach the temporal aspects of key players and activities specific to Romanian SME's ERP implementations with focus on both generic and unique aspects

  12. Colorectal cancer prevention: Perspectives of key players from social networks in a low-income rural US region

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    Nancy E. Schoenberg

    2016-02-01

    Full Text Available Social networks influence health behavior and health status. Within social networks, “key players” often influence those around them, particularly in traditionally underserved areas like the Appalachian region in the USA. From a total sample of 787 Appalachian residents, we identified and interviewed 10 key players in complex networks, asking them what comprises a key player, their role in their network and community, and ideas to overcome and increase colorectal cancer (CRC screening. Key players emphasized their communication skills, resourcefulness, and special occupational and educational status in the community. Barriers to CRC screening included negative perceptions of the colonoscopy screening procedure, discomfort with the medical system, and misinformed perspectives on screening. Ideas to improve screening focused on increasing awareness of women's susceptibility to CRC, providing information on different screening tests, improving access, and the key role of health-care providers and key players themselves. We provide recommendations to leverage these vital community resources.

  13. Diversity of key players in the microbial ecosystems of the human body.

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    Jordán, Ferenc; Lauria, Mario; Scotti, Marco; Nguyen, Thanh-Phuong; Praveen, Paurush; Morine, Melissa; Priami, Corrado

    2015-10-30

    Coexisting bacteria form various microbial communities in human body parts. In these ecosystems they interact in various ways and the properties of the interaction network can be related to the stability and functional diversity of the local bacterial community. In this study, we analyze the interaction network among bacterial OTUs in 11 locations of the human body. These belong to two major groups. One is the digestive system and the other is the female genital tract. In each local ecosystem we determine the key species, both the ones being in key positions in the interaction network and the ones that dominate by frequency. Beyond identifying the key players and discussing their biological relevance, we also quantify and compare the properties of the 11 networks. The interaction networks of the female genital system and the digestive system show totally different architecture. Both the topological properties and the identity of the key groups differ. Key groups represent four phyla of prokaryotes. Some groups appear in key positions in several locations, while others are assigned only to a single body part. The key groups of the digestive and the genital tracts are totally different.

  14. Nrf2 as a key player of redox regulation in cardiovascular diseases.

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    Barančík, M; Grešová, L; Barteková, M; Dovinová, I

    2016-09-19

    The oxidative stress plays an important role in the development of cardiovascular diseases (CVD). In CVD progression an aberrant redox regulation was observed. In this regulation levels of reactive oxygen species (ROS) play an important role in cellular signaling, where Nrf2 is the key regulator of redox homeostasis. Keap1-Nrf2-ARE system regulates a great set of detoxificant and antioxidant enzymes in cells after ROS and electrophiles exposure. In this review we focus on radical-generating systems in cardiovascular system as well as on Nrf2 as a target against oxidative stress and a key player of redox regulation in cardiovascular diseases. We also summarize the current knowledge about the role of Nrf2 in pathophysiology of several CVD (hypertension, cardiac hypertrophy, cardiomyopathies) as well as in cardioprotection against myocardial ischemia/ reperfusion injury.

  15. Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra.

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    Guo, Xiao-Xi; An, Su; Yang, Yang; Liu, Ying; Hao, Qian; Xu, Tian-Rui

    2016-01-01

    Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR), receptor tyrosine kinases (RTKs), ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis and carcinogenesis. The complexity and diversity of Rap functions are tightly regulated by Rap-interacting proteins such as GEFs, GAPs, Rap effectors and scaffold proteins. These interacting proteins decide the subcellular localization of Rap, the interaction modes with downstream Rap effectors and tune Rap as an atypical molecular conductor, coupling extra- and intracellular signals to various pathways. In this review, we summarize four groups of Rap-interacting proteins, highlight their distinctions in Rap-binding properties and interactive modes and discuss their contribution to the spatiotemporal regulation of Rap as well as the implications of targeting Rap-interacting proteins in human cancer therapy.

  16. Rap-Interacting Proteins are Key Players in the Rap Symphony Orchestra

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    Xiao-Xi Guo

    2016-06-01

    Full Text Available Rap, a member of the Ras-like small G-protein family, is a key node among G-protein coupled receptors (GPCR, receptor tyrosine kinases (RTKs, ion channels and many other downstream pathways. Rap plays a unique role in cell morphogenesis, adhesion, migration, exocytosis, proliferation, apoptosis and carcinogenesis. The complexity and diversity of Rap functions are tightly regulated by Rap-interacting proteins such as GEFs, GAPs, Rap effectors and scaffold proteins. These interacting proteins decide the subcellular localization of Rap, the interaction modes with downstream Rap effectors and tune Rap as an atypical molecular conductor, coupling extra- and intracellular signals to various pathways. In this review, we summarize four groups of Rap-interacting proteins, highlight their distinctions in Rap-binding properties and interactive modes and discuss their contribution to the spatiotemporal regulation of Rap as well as the implications of targeting Rap-interacting proteins in human cancer therapy.

  17. Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Kiang, Karrie Mei-Yee; Zhang, Xiao-Qin; Leung, Gilberto Ka-Kit, E-mail: gilberto@hku.hk [Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong (China)

    2015-07-29

    Long non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system (CNS), will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed.

  18. History and Development of Coronal Mass Ejections as a Key Player in Solar Terrestrial Relationship

    CERN Document Server

    Gopalswamy, Nat

    2016-01-01

    Coronal mass ejections (CMEs) are relatively a recently-discovered phenomenon, in 1971, some fifteen years into the Space Era. It took another two decades to realize that CMEs are the most important players in solar terrestrial relationship as the root cause of severe weather in Earth's space environment. CMEs are now counted among the major natural hazards because they cause large solar energetic particle (SEP) events and major geomagnetic storms, both of which pose danger to humans and their technology in space and ground. Geomagnetic storms discovered in the 1700s, solar flares discovered in the 1800s, and SEP events discovered in the1900s are all now found to be closely related to CMEs via various physical processes occurring at various locations in and around CMEs, when they interact with the ambient medium. This article identifies a number of key developments that preceded the discovery of white-light CMEs suggesting that CMEs were waiting to be discovered. The last two decades witnessed an explosion of...

  19. Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions.

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    Shannan Cao

    Full Text Available In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the acid environment, neutrophil apoptosis delayed, respiratory burst inhibited, polarization augmented, chemotaxis differed, endocytosis enhanced and bacteria killing suppressed. These findings suggested that extracellular acidification acts as a key regulator of neutrophil apoptosis and functions.

  20. Key players of singlet oxygen-induced cell death in plants

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    Laloi, Christophe; Havaux, Michel

    2015-01-01

    The production of reactive oxygen species (ROS) is an unavoidable consequence of oxygenic photosynthesis. Singlet oxygen (1O2) is a highly reactive species to which has been attributed a major destructive role during the execution of ROS-induced cell death in photosynthetic tissues exposed to excess light. The study of the specific biological activity of 1O2 in plants has been hindered by its high reactivity and short lifetime, the concurrent production of other ROS under photooxidative stress, and limited in vivo detection methods. However, during the last 15 years, the isolation and characterization of two 1O2-overproducing mutants in Arabidopsis thaliana, flu and ch1, has allowed the identification of genetically controlled 1O2 cell death pathways and a 1O2 acclimation pathway that are triggered at sub-cytotoxic concentrations of 1O2. The study of flu has revealed the control of cell death by the plastid proteins EXECUTER (EX)1 and EX2. In ch1, oxidized derivatives of β-carotene, such as β-cyclocitral and dihydroactinidiolide, have been identified as important upstream messengers in the 1O2 signaling pathway that leads to stress acclimation. In both the flu and ch1 mutants, phytohormones act as important promoters or inhibitors of cell death. In particular, jasmonate has emerged as a key player in the decision between acclimation and cell death in response to 1O2. Although the flu and ch1 mutants show many similarities, especially regarding their gene expression profiles, key differences, such as EXECUTER-independent cell death in ch1, have also been observed and will need further investigation to be fully understood. PMID:25699067

  1. Developing Talented Soccer Players: An Analysis of Socio-Spatial Factors as Possible Key Constraints

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    Serra-Olivares Jaime

    2016-12-01

    Full Text Available Most studies on the identification and development of soccer talent have been one-dimensional in nature. Although some multi-dimensional analyses have been conducted, few research studies have assessed in any depth the socio-spatial factors influencing talent development. The aim of this particular study was to analyse variations in the international representation of clubs (n = 821 and countries (n = 59 in the development of players who took part in the 2014 FIFA Soccer World Cup. Clubs and countries were ranked and divided into quartiles according to the number of players developed between the ages of 15 and 21 (clubs and countries that developed players for at least three years between these ages and the number of official league matches played by these players up to the age of 23. Significant variations were observed between clubs in terms of the number of developed players who took part in the World Cup and the number of official league matches played by these players up to the age of 23 (p < .05, and also between countries (p < .05. The findings reveal the need to carry out more in-depth studies into the type of training and competition engaged in by elite players in the period of development between the ages of 15 and 21. It may be the case that these factors are potentially decisive socio-spatial constraints in the development of soccer talent.

  2. Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.

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    Kong, Ruirui; Yi, Fengshuang; Wen, Pushuai; Liu, Jianghong; Chen, Xiaoping; Ren, Jinqi; Li, Xiaofei; Shang, Yulong; Nie, Yongzhan; Wu, Kaichun; Fan, Daiming; Zhu, Li; Feng, Wei; Wu, Jane Y

    2015-11-03

    Emerging evidence indicates that the neuronal guidance molecule SLIT plays a role in tumor suppression, as SLIT-encoding genes are inactivated in several types of cancer, including lung cancer; however, it is not clear how SLIT functions in lung cancer. Here, our data show that SLIT inhibits cancer cell migration by activating RhoA and that myosin 9b (Myo9b) is a ROBO-interacting protein that suppresses RhoA activity in lung cancer cells. Structural analyses revealed that the RhoGAP domain of Myo9b contains a unique patch that specifically recognizes RhoA. We also determined that the ROBO intracellular domain interacts with the Myo9b RhoGAP domain and inhibits its activity; therefore, SLIT-dependent activation of RhoA is mediated by ROBO inhibition of Myo9b. In a murine model, compared with control lung cancer cells, SLIT-expressing cells had a decreased capacity for tumor formation and lung metastasis. Evaluation of human lung cancer and adjacent nontumor tissues revealed that Myo9b is upregulated in the cancer tissue. Moreover, elevated Myo9b expression was associated with lung cancer progression and poor prognosis. Together, our data identify Myo9b as a key player in lung cancer and as a ROBO-interacting protein in what is, to the best of our knowledge, a newly defined SLIT/ROBO/Myo9b/RhoA signaling pathway that restricts lung cancer progression and metastasis. Additionally, our work suggests that targeting the SLIT/ROBO/Myo9b/RhoA pathway has potential as a diagnostic and therapeutic strategy for lung cancer.

  3. IMPLEMENTATION OF GREEN BUILDING INCENTIVES FOR CONSTRUCTION KEY PLAYERS IN MALAYSIA

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    SITI ZUBAIDAH HASHIM

    2016-04-01

    Full Text Available A Green Building Index (GBI is a pioneer in a building grading system to promote sustainability and increase awareness upon environmental issue in Malaysia. The GBI was first established by Malaysia Architect Association (PAM and Association of Consulting Engineers Malaysia (ACEM in February 2009. As a green building contribution on sustainable development and energy efficiency, government has introduced incentives to parties who involve in obtaining Green Building Index Certificate to inculcate vgreen technology. The present paper articulates various categories of incentives introduced by government for construction key players in Malaysia and compare those incentives implies worldwide including countries such as United States, United Kingdom, Australia and Singapore. The incentives are categories into three; financial incentives, fiscal incentives and structure incentives. In a case of financial incentives the financial grants, loans, fund, vouchers, rebates and etc. attract building developers to adopt green elements and apply for certification in their new building project. Obviously, most developers more engrossed to the incentives which has a direct impact on the project financial cash flow. Fiscal incentive however is a privilege by the government, in term of tax exemption granted to respective green building project. Structural incentives are much common incentives offered by government because it would not require expenditure of fund and not reduce the income of city and county. By comparing few successful model of incentives by several countries, the present research reveals that the structure of incentives for green building in Malaysia should have more focused on structural incentive especially those involves technical support, expedited building permit and Gross Floor Area (GFA equivalent incentive scheme.

  4. Cellular Players in the Herpes Simplex Virus Dependent Apoptosis Balancing Act

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    John A. Blaho

    2009-11-01

    Full Text Available Apoptosis is triggered as an intrinsic defense against numerous viral infections. Almost every virus encodes apoptotic modulators, and the herpes simplex viruses (HSV are no exception. During HSV infection, there is an intricate balance between pro- and anti-apoptotic factors that delays apoptotic death until the virus has replicated. Perturbations in the apoptotic balance can cause premature cell death and have the potential to dramatically alter the outcome of infection. Recently, certain cellular genes have been shown to regulate sensitivity to HSV-dependent apoptosis. This review summarizes current knowledge of the cellular genes that impact the apoptotic balance during HSV infection.

  5. B-lymphocytes as key players in chemical-induced asthma.

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    Vanessa De Vooght

    Full Text Available T-lymphocytes and B-lymphocytes are key players in allergic asthma, with B-lymphocytes producing antigen-specific immunoglobulins E (IgE. We used a mouse model of chemical-induced asthma and transferred B-lymphocytes from sensitized animals into naïve wild type mice, B-lymphocyte knock-out (B-KO mice or severe combined immunodeficiency (SCID mice. On days 1 and 8, BALB/c mice were dermally sensitized with 0.3% toluene diisocyanate (TDI (20 µl/ear. On day 15, mice were euthanized and the auricular lymph nodes isolated. B-lymphocytes (CD19(+ were separated from the whole cell suspension and 175,000 cells were injected in the tail vein of naïve wild type, B-KO or SCID mice. Three days later, the mice received a single oropharyngeal challenge with 0.01% TDI (20 µl or vehicle (acetone/olive oil (AOO (controls. Airway reactivity to methacholine and total and differential cell counts in the bronchoalveolar lavage (BAL fluid were measured 24 hours after challenge. B-lymphocytes of AOO or TDI-sensitized mice were characterized for the expression of surface markers and production of cytokines. We found that transfer of B-cells obtained from mice dermally sensitized to toluene diisocyanate (TDI into naïve wild type mice, B-KO mice or SCID mice led, within three days, to an acute asthma-like phenotype after an airway challenge with TDI. This response was specific and independent of IgE. These B-lymphocytes showed antigen presenting capacities (CD80/CD86 and CD40 and consisted of B effector (Be2- (IL-4 and Be1-lymphocytes (IFN-γ. The transferred B-lymphocytes were visualized near large airways, 24 hours after TDI challenge. Thus, B-lymphocytes can provoke an asthmatic response without the action of T-lymphocytes and without major involvement of IgE.

  6. Camus' Actor as Tom Stoppard's Player; A Key to Interpreting "Rosencrantz and Guildenstern Are Dead."

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    Zivanovic, Judith

    An examination of Albert Camus' definition of the actor in "The Myth on Sisyphus" helps to illuminate the character and role of The Player in Tom Stoppard's play and, hence, to bring light to an understanding of the philosophy of the play itself. The actor, for Camus, reveals our mortality in the face of the absurdity of our mortality,…

  7. Organization of the upper limb movement for piano key-depression differs between expert pianists and novice players.

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    Furuya, Shinichi; Kinoshita, Hiroshi

    2008-03-01

    The present study investigated the expert-novice difference in the organization of upper-limb movement for the key-depression on the piano. Kinematic and electromyographic recordings were made while experts (N = 7) and novices (N = 7) of classical-piano players performed a right hand octave keystroke to produce four different sound dynamics. The joint torque generated at the key-bottom moment (key-force torque) was also estimated. At all sound dynamics, the experts showed a larger finger attack angle, more flexed shoulder, wrist, and MP joints, more extended elbow joint, and smaller key-force torque at the MP joint than the novices. The level of co-activation in the finger flexor-extensor muscles during the period prior to the key-bottom moment was also lower for the experts. To attain the large attack angle by the experts, as the fingertip depressed the key to the bottom, their shoulder was actively flexed, the forearm was thrust forward, and the hand was rotated forward. The novices, on the other hand, actively extended their shoulder to move the forearm and hand downward to depress the key. These results confirmed a substantial difference in the key-depression movement organization between the experts and novices. These findings also suggest that experts use a synergistically organized multi-joint limb motion that allows them to minimize the biomechanical load and muscular effort to the distal muscles. The novices, on the other hand, tend to rely on a rudimentary synergy of joint motion developed through daily experience.

  8. Network theory inspired analysis of time-resolved expression data reveals key players guiding P. patens stem cell development.

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    Busch, Hauke; Boerries, Melanie; Bao, Jie; Hanke, Sebastian T; Hiss, Manuel; Tiko, Theodhor; Rensing, Stefan A

    2013-01-01

    Transcription factors (TFs) often trigger developmental decisions, yet, their transcripts are often only moderately regulated and thus not easily detected by conventional statistics on expression data. Here we present a method that allows to determine such genes based on trajectory analysis of time-resolved transcriptome data. As a proof of principle, we have analysed apical stem cells of filamentous moss (P. patens) protonemata that develop from leaflets upon their detachment from the plant. By our novel correlation analysis of the post detachment transcriptome kinetics we predict five out of 1,058 TFs to be involved in the signaling leading to the establishment of pluripotency. Among the predicted regulators is the basic helix loop helix TF PpRSL1, which we show to be involved in the establishment of apical stem cells in P. patens. Our methodology is expected to aid analysis of key players of developmental decisions in complex plant and animal systems.

  9. Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

    NARCIS (Netherlands)

    De Keyser, Jacques; Mostert, Jop P.; Koch, Marcus W.

    2008-01-01

    Once considered little more than the glue that holds neurons in place, astrocytes are now becoming appreciated for the key roles they play in central nervous system functions. They supply neurons and oligodendrocytes with substrates for energy metabolism, control extracellular water and electrolyte

  10. Seizures beget seizures: the quest for GABA as a key player.

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    Ben-Ari, Yehezkel

    2006-01-01

    Synapses mediated by gamma-aminobutyric acid (GABA) A receptors are notoriously altered during periods of enhanced activity. Since a loss of inhibitory tone is a basic cause of seizures and epilepsies, it is important to determine the underlying mechanisms and the way this could be alleviated or at least reduced. Alterations of the intracellular content of chloride are thought to be a major player in the sequence of events that follow episodes of hyperactivity. In this review, I discuss these mechanisms both in the adult and developing brain, relying on studies in which chloride and GABAergic currents were measured by electrophysiological and imaging techniques. The main conclusion is that in adult systems, status epilepticus induces a complete re-organization of the networks, with cell death, axonal growth, and glutamatergic neosynapse formation leading to an increased glutamatergic drive. This, in turn, will decrease the threshold of seizure generation and thus contribute to seizure generation. In contrast, GABAergic synapses are not readily "plastic" as the lost interneurones and synapses are not replaced. Somatostatin-positive 0-LM Interneurons that innervate the dendrites of the principal cells in the hippocampus degenerate selectively, leading to a loss of the inhibitory drive in the dendrites, whereas somatic projecting basket cells and somatic inhibitory drives are relatively spared. This imbalance leads to a reduction of the inhibitory strength that is necessary but not sufficient to generate ongoing seizures. An additional important factor is the persistent increase of the intracellular chloride concentration that leads to a long-lasting shift in the depolarizing direction of the actions of GABA that will also contribute to seizure generation. In the developing brain, a major source of seizure generation is the depolarizing and often excitatory actions of GABA due to a higher intracellular chloride concentration ([Cl-]I) in immature neurons, a property

  11. Partnerships in medical business: a framework for choosing the right key players.

    Science.gov (United States)

    Dhawan, Naveen

    2013-01-01

    At a time when more and more physicians are opting for shared practices and embarking on business ventures, partnerships play a key role. The fate of a medical business is largely contingent upon the success of the partnership. In this article, the author introduces a practical framework for deciding whether to take on a partnership. The model considers six critical factors: financial compensation, special skill set, goal alignment, personality assessment, overall strengths and weaknesses, and trustworthiness. It also provides an evaluation of financial incentives. The paper also provides several action items for physicians.

  12. Dendritic cells in hepatitis C virus infection: key players in the IFNL3-genotype response.

    Science.gov (United States)

    O'Connor, Kate S; George, Jacob; Booth, David; Ahlenstiel, Golo

    2014-12-21

    Recently, single nucleotide polymorphisms, in the vicinity of the interferon lambda 3 (IFNL3) gene have been identified as the strongest predictor of spontaneous and treatment induced clearance of hepatitis C virus (HCV) infection. Since then, increasing evidence has implicated the innate immune response in mediating the IFNL3 genotype effect. Dendritic cells (DCs) are key to the host immune response in HCV infection and their vital role in the IFNL3 genotype effect is emerging. Reports have identified subclasses of DCs, particularly myeloid DC2s and potentially plasmacytoid DCs as the major producers of IFNL3 in the setting of HCV infection. Given the complexities of dendritic cell biology and the conflicting current available data, this review aims to summarize what is currently known regarding the role of dendritic cells in HCV infection and to place it into context of what is know about lambda interferons and dendritic cells in general.

  13. Dietary sodium, potassium, and alcohol: key players in the pathophysiology, prevention, and treatment of human hypertension.

    Science.gov (United States)

    Koliaki, Chrysi; Katsilambros, Nicholas

    2013-06-01

    Western industrialized societies are currently experiencing an epidemic expansion of hypertension (HTN), which extends alarmingly even to children and adolescents. HTN constitutes an independent risk factor for cardiorenal disease and represents an extremely common comorbidity of diabetes and obesity. Numerous randomized clinical trials and meta-analyses have provided robust scientific evidence that reduced dietary salt intake, increased dietary potassium intake, moderation of alcohol consumption, optimal weight maintenance, and the adoption of "heart-friendly" dietary patterns such as the Dietary Approaches to Stop Hypertension or the Mediterranean diet can effectively lower blood pressure. Interestingly, the susceptibility of blood pressure to nutritional interventions is greatly variable among individuals, depending on age, race, genetic background, and comorbidities. The purpose of this review is to provide a comprehensive overview of currently available scientific evidence in the constantly evolving field of diet and HTN, placing particular emphasis on the key role of dietary sodium, dietary potassium, and alcohol intake in the pathophysiology, prevention, and treatment of human hypertension.

  14. Glycosyltransferases:key players involved in the modification of plant secondary metabolites

    Institute of Scientific and Technical Information of China (English)

    Jun WANG; Bingkai HOU

    2009-01-01

    Glycosyltransferases are members of the multigene superfamily in plants that can transfer single or multiple activated sugars to a range of plant molecules,resulting in the glycosylation of plant compounds.Although the activities of many glycosyltransferases and their products have been recognized for a long time,only in recent years were some glycosyltransferase genes identified and a few functionally characterized in detail.Glycosylation is thought to be one of the most important modification reactions towards plant secondary metabolites,and plays a key role in maintaining cell homeostasis,thus likely participating in the regulation of plant growth,development and in defense responses to stress environments.With advances in plant genome projects and the development of novel technologies in analyzing gene function,significant progress could be made in gaining new insights into the properties and precise biological roles of plant secondary product glycosyltransferases,and the new knowledge will have extensive application prospects in the catalytic synthesis of glycoconjugates and metabolic engineering of crops.In this review,we summarize the current research,highlighting the possible biological roles,of plant secondary metabolite glycosyltransferases and discuss their potential applications as well as aspects to be further studied in the near future.

  15. Gut microbiota: a key player in health and disease. A review focused on obesity.

    Science.gov (United States)

    Villanueva-Millán, M J; Pérez-Matute, P; Oteo, J A

    2015-09-01

    Gut microbiota, its evolutive dynamics and influence on host through its protective, trophic and metabolic actions, has a key role in health and opens unique opportunities for the identification of new markers of the physiopathological state of each individual. Alterations in gut microbiota composition have been associated with plenty disorders. Of interest, the vast number of studies demonstrates the role of microbiota in obesity, a serious public health problem that has reached epidemic proportions in many developed and middle-income countries. The economic and health costs of this condition and its comorbidities such as fatty liver, insulin resistance/diabetes, or cardiovascular events are considerable. Therefore, every strategy designed to reduce obesity would imply important savings. Targeting microbiota, in order to restore/modulate the microbiota composition with antibiotics, probiotics, prebiotics, or even fecal transplants, is considered as a promising strategy for the development of new solutions for the treatment of obesity. However, there is still lot to do in this field in order to identify the exact composition of microbiota in "health" and the specific mechanisms that regulate the host-microbiotal crosstalk. In addition, it is important to note that changes not only in the gut microbiota profile (abundance) but also in its metabolism and functions need to be taken into account in the context of contribution in the physiopathology of obesity and related disorders.

  16. KEY PLAYERS IN CHOLINE METABOLIC REPROGRAMMING IN TRIPLE NEGATIVE BREAST CANCER

    Directory of Open Access Journals (Sweden)

    Egidio Iorio

    2016-09-01

    Full Text Available Triple negative breast cancer (TNBC, defined by lack of estrogen and progesterone receptors in the absence of protein overexpression/gene amplification of human epidermal growth factor receptor 2 (HER2, is still a clinical challenge despite progress in breast cancer (BC care. 1H magnetic resonance spectroscopy (MRS allows identification and non-invasive monitoring of TNBC metabolic aberrations and elucidation of some key mechanisms underlying tumor progression. Thus, it has the potential to improve in vivo diagnosis and follow-up, and identify new targets for treatment. Several studies have shown an altered phosphatidylcholine (PtdCho metabolism in TNBCs, both in patients and in experimental models. Up-regulation of choline kinase-alpha, an enzyme of the Kennedy pathway that phosphorylates free choline (Cho to phosphocholine (PCho, is a major contributor to the increased PCho content detected in TNBCs. Phospholipase-mediated PtdCho headgroup hydrolysis also contributes to the build-up of a PCho pool in TNBC cells. The oncogene-driven PtdCho cycle appears to be fine tuned in TNBC cells in at least three ways: by modulating the choline import, by regulating the activity or expression of specific metabolic enzymes, and by contributing to the rewiring of the entire metabolic network. Thus, only by thoroughly dissecting these mechanisms, it will be possible to effectively translate this basic knowledge into further development and implementation of Cho-based imaging techniques and novel classes of therapeutics.

  17. Underlying Motives, Moral Agendas and Unlikely Partnerships: The Formulation of the U.S. Trafficking in Victims Protection Act Through the Data and Voices of Key Policy Players

    Directory of Open Access Journals (Sweden)

    Nicole Footen Bromfield

    2012-08-01

    Full Text Available In response to the overwhelming amount of attention to human trafficking, the debates surrounding its definition, and its focus on the sex industry, the purpose of this study was to understand the motivations behind the formation of the Trafficking in Victims Protection Act (TVPA. Using the Advocacy Coalition Framework (ACF as a model, data was collected and analyzed in order to examine the coalition identities of key players and their positions. Through the presentation of in-depth interview data with key policy players involved in the making of the TVPA, this article illustrates how and why the TVPA was formulated, the implications of its development, and the necessity for critical analysis of its effects. The use of alternative frameworks of labor and migration for understanding trafficking is proposed. Further consideration is given to legislative changes to eliminate anti-prostitution ideology and to support anti-oppressive approaches to addressing forced or deceptive working conditions.

  18. T cell–mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis

    Science.gov (United States)

    Trautmann, Axel; Akdis, Mübeccel; Kleemann, Daniela; Altznauer, Frank; Simon, Hans-Uwe; Graeve, Thomas; Noll, Michaela; Bröcker, Eva-B.; Blaser, Kurt; Akdis, Cezmi A.

    2000-01-01

    Clinical and histologic similarities between various eczematous disorders point to a common efferent pathway. We demonstrate here that activated T cells infiltrating the skin in atopic dermatitis (AD) and allergic contact dermatitis (ACD) induce keratinocyte (KC) apoptosis. KCs normally express low levels of Fas receptor (FasR) that can be substantially enhanced by the presence of IFN-γ. KCs are rendered susceptible to apoptosis by IFN-γ when FasR numbers reach a threshold of approximately 40,000 per KC. Subsequently, KCs undergo apoptosis induced by anti-FasR mAb’s, soluble Fas ligand, supernatants from activated T cells, or direct contact between T cells and KCs. Apoptotic KCs show typical DNA fragmentation and membrane phosphatidylserine expression. KC apoptosis was demonstrated in situ in lesional skin affected by AD, ACD, and patch tests. Using numerous cytokines and anti-cytokine neutralizing mAb’s, we found no evidence that cytokines other than IFN-γ participate in this process. In addition, apoptosis-inducing pathways other than FasR triggering were ruled out by blocking T cell–induced KC apoptosis by caspase inhibitors and soluble Fas-Fc protein. Responses of normal human skin and cultured skin equivalents to activated T cells demonstrated that KC apoptosis caused by skin-infiltrating T cells is a key event in the pathogenesis of eczematous dermatitis. PMID:10880045

  19. Network structure and the role of key players in a translational cancer research network: a study protocol

    OpenAIRE

    Long, Janet C; Cunningham, Frances C.; Braithwaite, Jeffrey

    2012-01-01

    Introduction Translational research networks are a deliberate strategy to bridge the gulf between biomedical research and clinical practice through interdisciplinary collaboration, supportive funding and infrastructure. The social network approach examines how the structure of the network and players who hold important positions within it constrain or enable function. This information can be used to guide network management and optimise its operations. The aim of this study was to describe th...

  20. A strategic game between key players in a competitive oil market; Um jogo estrategico entre atores-chave em um mercado competitivo de petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Medina, Fernando; Ferreira Filho, Virgilio Jose Martins [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia (COPPE)

    2004-07-01

    This article aims to state a strategic game devised in Theory Game, regarding some aspects present in a highly competitive oil market. A set of strategies for two key players of the world oil industry is created. Both of them are in a conflict of economic interest and make decisions based on rational and conservative principles. Pure and mixed strategies, the minimax optimizing method and the concept of Nash Equilibrium among optimum strategies are used to calculate the expected value for decision for each actor in the game. (author)

  1. Upregulation of NOXA by 10-Hydroxycamptothecin plays a key role in inducing fibroblasts apoptosis and reducing epidural fibrosis

    Directory of Open Access Journals (Sweden)

    Jihang Dai

    2017-01-01

    the first to demonstrate that upregulation of NOXA by HCPT plays a key role in inducing fibroblast apoptosis and in reducing epidural fibrosis. These findings might provide a potential therapeutic target for preventing epidural fibrosis following laminectomy.

  2. Apoptosis in mammalian oocytes: a review.

    Science.gov (United States)

    Tiwari, Meenakshi; Prasad, Shilpa; Tripathi, Anima; Pandey, Ashutosh N; Ali, Irfan; Singh, Arvind K; Shrivastav, Tulsidas G; Chaube, Shail K

    2015-08-01

    Apoptosis causes elimination of more than 99% of germ cells from cohort of ovary through follicular atresia. Less than 1% of germ cells, which are culminated in oocytes further undergo apoptosis during last phases of oogenesis and depletes ovarian reserve in most of the mammalian species including human. There are several players that induce apoptosis directly or indirectly in oocytes at various stages of meiotic cell cycle. Premature removal of encircling granulosa cells from immature oocytes, reduced levels of adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate, increased levels of calcium (Ca(2+)) and oxidants, sustained reduced level of maturation promoting factor, depletion of survival factors, nutrients and cell cycle proteins, reduced meiotic competency, increased levels of proapoptotic as well as apoptotic factors lead to oocyte apoptosis. The BH3-only proteins also act as key regulators of apoptosis in oocyte within the ovary. Both intrinsic (mitochondria-mediated) as well as extrinsic (cell surface death receptor-mediated) pathways are involved in oocyte apoptosis. BID, a BH3-only protein act as a bridge between both apoptotic pathways and its cleavage activates cell death machinery of both the pathways inside the follicular microenvironment. Oocyte apoptosis leads to the depletion of ovarian reserve that directly affects reproductive outcome of various mammals including human. In this review article, we highlight some of the important players and describe the pathways involved during oocyte apoptosis in mammals.

  3. Tracing a key player in the regulation of plant architecture: the columnar growth habit of apple trees (Malus × domestica).

    Science.gov (United States)

    Petersen, Romina; Krost, Clemens

    2013-07-01

    Plant architecture is regulated by a complex interplay of some key players (often transcription factors), phytohormones and other signaling molecules such as microRNAs. The columnar growth habit of apple trees is a unique form of plant architecture characterized by thick and upright stems showing a compaction of internodes and carrying short fruit spurs instead of lateral branches. The molecular basis for columnar growth is a single dominant allele of the gene Columnar, whose identity, function and gene product are unknown. As a result of marker analyses, this gene has recently been fine-mapped to chromosome 10 at 18.51-19.09 Mb [according to the annotation of the apple genome by Velasco (2010)], a region containing a cluster of quantitative trait loci associated with plant architecture, but no homologs to the well-known key regulators of plant architecture. Columnar apple trees have a higher auxin/cytokinin ratio and lower levels of gibberellins and abscisic acid than normal apple trees. Transcriptome analyses corroborate these results and additionally show differences in cell membrane and cell wall function. It can be expected that within the next year or two, an integration of these different research methodologies will reveal the identity of the Columnar gene. Besides enabling breeders to efficiently create new apple (and maybe related pear, peach, cherry, etc.) cultivars which combine desirable characteristics of commercial cultivars with the advantageous columnar growth habit using gene technology, this will also provide new insights into an elevated level of plant growth regulation.

  4. Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation

    Directory of Open Access Journals (Sweden)

    Maja Jazvinšćak Jembrek

    2015-01-01

    Full Text Available Alzheimer’s disease (AD, the most common chronic and progressive neurodegenerative disorder, is characterized by extracellular deposits of amyloid β-peptides (Aβ and intracellular deposits of hyperphosphorylated tau (phospho-tau protein. Ceramides, the major molecules of sphingolipid metabolism and lipid second messengers, have been associated with AD progression and pathology via Aβ generation. Enhanced levels of ceramides directly increase Aβ through stabilization of β-secretase, the key enzyme in the amyloidogenic processing of Aβ precursor protein (APP. As a positive feedback loop, the generated oligomeric and fibrillar Aβ induces a further increase in ceramide levels by activating sphingomyelinases that catalyze the catabolic breakdown of sphingomyelin to ceramide. Evidence also supports important role of ceramides in neuronal apoptosis. Ceramides may initiate a cascade of biochemical alterations, which ultimately leads to neuronal death by diverse mechanisms, including depolarization and permeabilization of mitochondria, increased production of reactive oxygen species (ROS, cytochrome c release, Bcl-2 depletion, and caspase-3 activation, mainly by modulating intracellular signalling, particularly along the pathways related to Akt/PKB kinase and mitogen-activated protein kinases (MAPKs. This review summarizes recent findings related to the role of ceramides in oxidative stress-driven neuronal apoptosis and interplay with Aβ in the cascade of events ending in neuronal degeneration.

  5. Rapidly Evolving Genes Are Key Players in Host Specialization and Virulence of the Fungal Wheat Pathogen Zymoseptoria tritici (Mycosphaerella graminicola.

    Directory of Open Access Journals (Sweden)

    Stephan Poppe

    2015-07-01

    Full Text Available The speciation of pathogens can be driven by divergent host specialization. Specialization to a new host is possible via the acquisition of advantageous mutations fixed by positive selection. Comparative genome analyses of closely related species allows for the identification of such key substitutions via inference of genome-wide signatures of positive selection. We previously used a comparative genomics framework to identify genes that have evolved under positive selection during speciation of the prominent wheat pathogen Zymoseptoria tritici (synonym Mycosphaerella graminicola. In this study, we conducted functional analyses of four genes exhibiting strong signatures of positive selection in Z. tritici. We deleted the four genes in Z. tritici and confirm a virulence-related role of three of the four genes ΔZt80707, ΔZt89160 and ΔZt103264. The two mutants ΔZt80707 and ΔZt103264 show a significant reduction in virulence during infection of wheat; the ΔZt89160 mutant causes a hypervirulent phenotype in wheat. Mutant phenotypes of ΔZt80707, ΔZt89160 and ΔZt103264 can be restored by insertion of the wild-type genes. However, the insertion of the Zt80707 and Zt89160 orthologs from Z. pseudotritici and Z. ardabiliae do not restore wild-type levels of virulence, suggesting that positively selected substitutions in Z. tritici may relate to divergent host specialization. Interestingly, the gene Zt80707 encodes also a secretion signal that targets the protein for cell secretion. This secretion signal is however only transcribed in Z. tritici, suggesting that Z. tritici-specific substitutions relate to a new function of the protein in the extracellular space of the wheat-Z. tritici interaction. Together, the results presented here highlight that Zt80707, Zt103264 and Zt89160 represent key genes involved in virulence and host-specific disease development of Z. tritici. Our findings illustrate that evolutionary predictions provide a powerful tool

  6. Rapidly Evolving Genes Are Key Players in Host Specialization and Virulence of the Fungal Wheat Pathogen Zymoseptoria tritici (Mycosphaerella graminicola)

    Science.gov (United States)

    Poppe, Stephan; Dorsheimer, Lena; Happel, Petra; Stukenbrock, Eva Holtgrewe

    2015-01-01

    The speciation of pathogens can be driven by divergent host specialization. Specialization to a new host is possible via the acquisition of advantageous mutations fixed by positive selection. Comparative genome analyses of closely related species allows for the identification of such key substitutions via inference of genome-wide signatures of positive selection. We previously used a comparative genomics framework to identify genes that have evolved under positive selection during speciation of the prominent wheat pathogen Zymoseptoria tritici (synonym Mycosphaerella graminicola). In this study, we conducted functional analyses of four genes exhibiting strong signatures of positive selection in Z. tritici. We deleted the four genes in Z. tritici and confirm a virulence-related role of three of the four genes ΔZt80707, ΔZt89160 and ΔZt103264. The two mutants ΔZt80707 and ΔZt103264 show a significant reduction in virulence during infection of wheat; the ΔZt89160 mutant causes a hypervirulent phenotype in wheat. Mutant phenotypes of ΔZt80707, ΔZt89160 and ΔZt103264 can be restored by insertion of the wild-type genes. However, the insertion of the Zt80707 and Zt89160 orthologs from Z. pseudotritici and Z. ardabiliae do not restore wild-type levels of virulence, suggesting that positively selected substitutions in Z. tritici may relate to divergent host specialization. Interestingly, the gene Zt80707 encodes also a secretion signal that targets the protein for cell secretion. This secretion signal is however only transcribed in Z. tritici, suggesting that Z. tritici-specific substitutions relate to a new function of the protein in the extracellular space of the wheat-Z. tritici interaction. Together, the results presented here highlight that Zt80707, Zt103264 and Zt89160 represent key genes involved in virulence and host-specific disease development of Z. tritici. Our findings illustrate that evolutionary predictions provide a powerful tool for the

  7. Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity

    Science.gov (United States)

    Gaje, Pusa Nela; Amalia Ceausu, Raluca; Jitariu, Adriana; Popovici, Ramona Amina; Raica, Marius

    2016-01-01

    Although mast cells (MCs) have been discovered over 130 years ago, their function was almost exclusively linked to allergic affections. At the time being, it is well known that MCs possess a great variety of roles, in both physiologic and pathologic conditions. In the oral tissues, MCs release different proinflammatory cytokines, tumor necrosis factor alpha (TNF-α), that promote leukocyte infiltration in various inflammatory states of the oral cavity. These cells play a key role in the inflammatory process and, as a consequence, their number changes in different pathologic conditions of the oral cavity, like gingivitis, periodontitis, and so on. MCs also represent a rich source of proteases, especially of mast cell tryptase and chymase, which directly degrade the extracellular matrix through their proteolytic activity and thus indirectly stimulate angiogenesis and facilitate invasion and metastasis. It may be stated that mast cells could have an impact on primary tumor development, progression, and metastases in oral squamous cell carcinoma. By understanding the role of mast cells in the pathogenesis of different inflammatory and tumor diseases of the oral cavity, these cells may become therapeutic targets that could possibly improve the prognosis and survival of these patients. PMID:27847826

  8. The South Atlantic Anticyclone as a key player for the representation of the tropical Atlantic climate in coupled climate models

    Science.gov (United States)

    Cabos, William; Sein, Dmitry V.; Pinto, Joaquim G.; Fink, Andreas H.; Koldunov, Nikolay V.; Alvarez, Francisco; Izquierdo, Alfredo; Keenlyside, Noel; Jacob, Daniela

    2016-08-01

    The key role of the South Atlantic Anticyclone (SAA) on the seasonal cycle of the tropical Atlantic is investigated with a regionally coupled atmosphere-ocean model for two different coupled domains. Both domains include the equatorial Atlantic and a large portion of the northern tropical Atlantic, but one extends southward, and the other northwestward. The SAA is simulated as internal model variability in the former, and is prescribed as external forcing in the latter. In the first case, the model shows significant warm biases in sea surface temperature (SST) in the Angola-Benguela front zone. If the SAA is externally prescribed, these biases are substantially reduced. The biases are both of oceanic and atmospheric origin, and are influenced by ocean-atmosphere interactions in coupled runs. The strong SST austral summer biases are associated with a weaker SAA, which weakens the winds over the southeastern tropical Atlantic, deepens the thermocline and prevents the local coastal upwelling of colder water. The biases in the basins interior in this season could be related to the advection and eddy transport of the coastal warm anomalies. In winter, the deeper thermocline and atmospheric fluxes are probably the main biases sources. Biases in incoming solar radiation and thus cloudiness seem to be a secondary effect only observed in austral winter. We conclude that the external prescription of the SAA south of 20°S improves the simulation of the seasonal cycle over the tropical Atlantic, revealing the fundamental role of this anticyclone in shaping the climate over this region.

  9. Veto players

    NARCIS (Netherlands)

    Warntjen, Andreas; Dowding, Keith

    2010-01-01

    Veto players are political actors whose consent is necessary to adopt a new policy. Put otherwise, they have veto power which allows them to prevent a change to the status quo. The concept is crucial to the influential veto player theory developed by George Tsebelis. Building on earlier work in form

  10. Dopaminergic D2 receptor is a key player in the substantia nigra pars compacta neuronal activation mediated by REM sleep deprivation.

    Science.gov (United States)

    Proença, Mariana B; Dombrowski, Patrícia A; Da Cunha, Claudio; Fischer, Luana; Ferraz, Anete C; Lima, Marcelo M S

    2014-01-01

    Currently, several studies addresses the novel link between sleep and dopaminergic neurotransmission, focusing most closely on the mechanisms by which Parkinson's disease (PD) and sleep may be intertwined. Therefore, variations in the activity of afferents during the sleep cycles, either at the level of DA cell bodies in the ventral tegmental area (VTA) and/or substantia nigra pars compacta (SNpc) or at the level of dopamine (DA) terminals in limbic areas may impact functions such as memory. Accordingly, we performed striatal and hippocampal neurochemical quantifications of DA, serotonin (5-HT) and metabolites of rats intraperitoneally treated with haloperidol (1.5 mg/kg) or piribedil (8 mg/kg) and submitted to REM sleep deprivation (REMSD) and sleep rebound (REB). Also, we evaluated the effects of REMSD on motor and cognitive parameters and SNpc c-Fos neuronal immunoreactivity. The results indicated that DA release was strongly enhanced by piribedil in the REMSD group. In opposite, haloperidol prevented that alteration. A c-Fos activation characteristic of REMSD was affected in a synergic manner by piribedil, indicating a strong positive correlation between striatal DA levels and nigral c-Fos activation. Hence, we suggest that memory process is severely impacted by both D2 blockade and REMSD and was even more by its combination. Conversely, the activation of D2 receptor counteracted such memory impairment. Therefore, the present evidence reinforce that the D2 receptor is a key player in the SNpc neuronal activation mediated by REMSD, as a consequence these changes may have direct impact for cognitive and sleep abnormalities found in patients with PD. This article is part of the Special Issue entitled 'The Synaptic Basis of Neurodegenerative Disorders'.

  11. TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress.

    Science.gov (United States)

    Dufour, Florent; Rattier, Thibault; Constantinescu, Andrei Alexandru; Zischler, Luciana; Morlé, Aymeric; Ben Mabrouk, Hazem; Humblin, Etienne; Jacquemin, Guillaume; Szegezdi, Eva; Delacote, Fabien; Marrakchi, Naziha; Guichard, Gilles; Pellat-Deceunynck, Catherine; Vacher, Pierre; Legembre, Patrick; Garrido, Carmen; Micheau, Olivier

    2017-02-07

    TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion have solely been described to occur through TRAIL-R2. Using the TALEN gene-editing approach, we show that TRAIL-R1 can also induce apoptosis during unresolved unfolded protein response (UPR). Likewise, TRAIL-R1 was found to co-immunoprecipitate with FADD and caspase-8 during ER stress. Its deficiency conferred resistance to apoptosis induced by thaspigargin, tunicamycin or brefeldin A. Our data also demonstrate that tumor cell motility and invasion-induced by TRAIL-R2 is not cell autonomous but induced in a TRAIL-dependant manner. TRAIL-R1, on the other hand, is unable to trigger cell migration owing to its inability to induce an increase in calcium flux. Importantly, all the isogenic cell lines generated in this study revealed that apoptosis induced TRAIL is preferentially induced by TRAIL-R1. Taken together, our results provide novel insights into the physiological functions of TRAIL-R1 and TRAIL-R2 and suggest that targeting TRAIL-R1 for anticancer therapy is likely to be more appropriate owing to its lack of pro-motile signaling capability.

  12. Autophagy and apoptosis: where do they meet?

    Science.gov (United States)

    Mukhopadhyay, Subhadip; Panda, Prashanta Kumar; Sinha, Niharika; Das, Durgesh Nandini; Bhutia, Sujit Kumar

    2014-04-01

    Autophagy and apoptosis are two important cellular processes with complex and intersecting protein networks; as such, they have been the subjects of intense investigation. Recent advances have elucidated the key players and their molecular circuitry. For instance, the discovery of Beclin-1's interacting partners has resulted in the identification of Bcl-2 as a central regulator of autophagy and apoptosis, which functions by interacting with both Beclin-1 and Bax/Bak respectively. When localized to the endoplasmic reticulum and mitochondria, Bcl-2 inhibits autophagy. Cellular stress causes the displacement of Bcl-2 from Beclin-1 and Bax, thereby triggering autophagy and apoptosis, respectively. The induction of autophagy or apoptosis results in disruption of complexes by BH3-only proteins and through post-translational modification. The mechanisms linking autophagy and apoptosis are not fully defined; however, recent discoveries have revealed that several apoptotic proteins (e.g., PUMA, Noxa, Nix, Bax, XIAP, and Bim) modulate autophagy. Moreover, autophagic proteins that control nucleation and elongation regulate intrinsic apoptosis through calpain- and caspase-mediated cleavage of autophagy-related proteins, which switches the cellular program from autophagy to apoptosis. Similarly, several autophagic proteins are implicated in extrinsic apoptosis. This highlights a dual cellular role for autophagy. On one hand, autophagy degrades damaged mitochondria and caspases, and on the other hand, it provides a membrane-based intracellular platform for caspase processing in the regulation of apoptosis. In this review, we highlight the crucial factors governing the crosstalk between autophagy and apoptosis and describe the mechanisms controlling cell survival and cell death.

  13. Caspase-10 Is the Key Initiator Caspase Involved in Tributyltin-Mediated Apoptosis in Human Immune Cells

    Directory of Open Access Journals (Sweden)

    Harald F. Krug

    2012-01-01

    Full Text Available Tributyltin (TBT is one of the most toxic compounds produced by man and distributed in the environment. A multitude of toxic activities have been described, for example, immunotoxic, neurotoxic, and endocrine disruptive effects. Moreover, it has been shown for many cell types that they undergo apoptosis after treatment with TBT and the cell death of immune cells could be the molecular background of its immunotoxic effect. As low as 200 nM up to 1 μM of TBT induces all signs of apoptosis in Jurkat T cells within 1 to 24 hrs of treatment. When compared to Fas-ligand control stimulation, the same sequence of events occurs: membrane blebbing, phosphatidylserine externalisation, the activation of the “death-inducing signalling complex,” and the following sequence of cleavage processes. In genetically modified caspase-8-deficient Jurkat cells, the apoptotic effects are only slightly reduced, whereas, in FADD-negative Jurkat cells, the TBT effect is significantly diminished. We could show that caspase-10 is recruited by the TRAIL-R2 receptor and apoptosis is totally prevented when caspase-10 is specifically inhibited in all three cell lines.

  14. Using fear appeals in warning labels to promote responsible gambling among VLT players: the key role of depth of information processing.

    Science.gov (United States)

    Munoz, Yaromir; Chebat, Jean-Charles; Suissa, Jacob Amnon

    2010-12-01

    Video lottery terminals (VLT) are a highly lucrative gambling format, but at the same time they are among the most hazardous. Previous research has shown that threatening warnings may be an appropriate approach for promoting protective behavior. The present study explores the potential benefits of threatening warnings in the fight against compulsive gambling. A 4 × 2 factorial design experiment was used to test our model based on both Elaboration Likelihood Model and Protection Motivation Theory. 258 VLT adult players (58% males, 42% females) with various degrees of problem gambling were exposed to three threat levels (plus a control condition) from two different sources (i.e., either a medical source or a source related to the provider of VLT's). Our results show that both higher threat warnings and the medical source of warnings enhance Depth of Information Processing. It was also found that Depth of Information Processing affects positively attitude change and compliance intentions. The theoretical and managerial implications are discussed.

  15. Caveolin-1 plays a key role in the oleanolic acid-induced apoptosis of HL-60 cells.

    Science.gov (United States)

    Ma, Wei; Wang, Di-Di; Li, Li; Feng, Yu-Kuan; Gu, Hong-Mei; Zhu, Gui-Ming; Piao, Jin-Hua; Yang, Yu; Gao, Xu; Zhang, Peng-Xia

    2014-07-01

    Our previous study found that caveolin-1 (CAV-1) protein expression is upregulated during oleanolic acid (OA)-induced inhibition of proliferation and promotion of apoptosis in HL-60 cells. CAV-1 is the main structural protein component of caveolae, playing important roles in tumorigenesis and tumor development. It has been shown that cav-1 expression is lower in leukemia cancer cell lines SUP-B15, HL-60, THP-1 and K562 and in chronic lymphocytic leukemia primary (CLP) cells when compared with normal white blood cells, with the lowest cav-1 expression level found in HL-60 cells. To study the effects of cav-1 in HL-60 cells and the effects of cav-1 overexpression on OA drug efficacy, cav-1 was overexpressed in HL-60 cells using lentiviral-mediated transfection combined with OA treatment. The results showed that cav-1 overexpression inhibited HL-60 cell proliferation, promoted apoptosis, arrested the cell cycle in the G1 phase and inhibited activation of the PI3K/AKT/mTOR signaling pathway. Overexpression of CAV-1 also increased HL-60 cell sensitivity to OA. To further verify whether OA affects HL-60 cells via the activation of downstream signaling pathways by CAV-1, cav-1 gene expression was silenced using RNAi, and the cells were treated with OA to examine its efficacy. The results showed that after cav-1 silencing, OA had little effect on cell activity, apoptosis, the cell cycle and phosphorylation of HL-60 cells. This study is the first to show that CAV-1 plays a crucial role in the effects of OA on HL-60 cells.

  16. Combined analysis of mRNA and miRNA identifies dehydration and salinity responsive key molecular players in citrus roots

    Science.gov (United States)

    Xie, Rangjin; Zhang, Jin; Ma, Yanyan; Pan, Xiaoting; Dong, Cuicui; Pang, Shaoping; He, Shaolan; Deng, Lie; Yi, Shilai; Zheng, Yongqiang; Lv, Qiang

    2017-01-01

    Citrus is one of the most economically important fruit crops around world. Drought and salinity stresses adversely affected its productivity and fruit quality. However, the genetic regulatory networks and signaling pathways involved in drought and salinity remain to be elucidated. With RNA-seq and sRNA-seq, an integrative analysis of miRNA and mRNA expression profiling and their regulatory networks were conducted using citrus roots subjected to dehydration and salt treatment. Differentially expressed (DE) mRNA and miRNA profiles were obtained according to fold change analysis and the relationships between miRNAs and target mRNAs were found to be coherent and incoherent in the regulatory networks. GO enrichment analysis revealed that some crucial biological processes related to signal transduction (e.g. ‘MAPK cascade’), hormone-mediated signaling pathways (e.g. abscisic acid- activated signaling pathway’), reactive oxygen species (ROS) metabolic process (e.g. ‘hydrogen peroxide catabolic process’) and transcription factors (e.g., ‘MYB, ZFP and bZIP’) were involved in dehydration and/or salt treatment. The molecular players in response to dehydration and salt treatment were partially overlapping. Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) analysis further confirmed the results from RNA-seq and sRNA-seq analysis. This study provides new insights into the molecular mechanisms how citrus roots respond to dehydration and salt treatment. PMID:28165059

  17. Genetic analysis of interferon induced thyroiditis (IIT): evidence for a key role for MHC and apoptosis related genes and pathways.

    Science.gov (United States)

    Hasham, Alia; Zhang, Weijia; Lotay, Vaneet; Haggerty, Shannon; Stefan, Mihaela; Concepcion, Erlinda; Dieterich, Douglas T; Tomer, Yaron

    2013-08-01

    Autoimmune thyroid diseases (AITD) have become increasingly recognized as a complication of interferon-alpha (IFNα) therapy in patients with chronic Hepatitis C virus (HCV) infection. Interferon-induced thyroiditis (IIT) can manifest as clinical thyroiditis in approximately 15% of HCV patients receiving IFNα and subclinical thyroiditis in up to 40% of patients, possibly resulting in either dose reduction or discontinuation of IFNα treatment. However, the exact mechanisms that lead to the development of IIT are unknown and may include IFNα-mediated immune-recruitment as well as direct toxic effects on thyroid follicular cells. We hypothesized that IIT develops in genetically predisposed individuals whose threshold for developing thyroiditis is lowered by IFNα. Therefore, our aim was to identify the susceptibility genes for IIT. We used a genomic convergence approach combining genetic association data with transcriptome analysis of genes upregulated by IFNα. Integrating results of genetic association, transcriptome data, pathway, and haplotype analyses enabled the identification of 3 putative loci, SP100/110/140 (2q37.1), HLA (6p21.3), and TAP1 (6p21.3) that may be involved in the pathogenesis of IIT. Immune-regulation and apoptosis emerged as the predominant mechanisms underlying the etiology of IIT.

  18. cAMP and EPAC are key players in the regulation of the signal transduction pathway involved in the α-hemolysin autophagic response.

    Directory of Open Access Journals (Sweden)

    María Belén Mestre

    Full Text Available Staphylococcus aureus is a microorganism that causes serious diseases in the human being. This microorganism is able to escape the phagolysosomal pathway, increasing intracellular bacterial survival and killing the eukaryotic host cell to spread the infection. One of the key features of S. aureus infection is the production of a series of virulence factors, including secreted enzymes and toxins. We have shown that the pore-forming toxin α-hemolysin (Hla is the S. aureus-secreted factor responsible for the activation of the autophagic pathway and that this response occurs through a PI3K/Beclin1-independent form. In the present report we demonstrate that cAMP has a key role in the regulation of this autophagic response. Our results indicate that cAMP is able to inhibit the autophagy induced by Hla and that PKA, the classical cAMP effector, does not participate in this regulation. We present evidence that EPAC and Rap2b, through calpain activation, are the proteins involved in the regulation of Hla-induced autophagy. Similar results were obtained in cells infected with different S. aureus strains. Interestingly, in this report we show, for the first time to our knowledge, that both EPAC and Rap2b are recruited to the S. aureus-containing phagosome. We believe that our findings have important implications in understanding innate immune processes involved in intracellular pathogen invasion of the host cell.

  19. Copper-Containing Amine Oxidases and FAD-Dependent Polyamine Oxidases Are Key Players in Plant Tissue Differentiation and Organ Development.

    Science.gov (United States)

    Tavladoraki, Paraskevi; Cona, Alessandra; Angelini, Riccardo

    2016-01-01

    Plant polyamines are catabolized by two classes of amine oxidases, the copper amine oxidases (CuAOs) and the flavin adenine dinucleotide (FAD)-dependent polyamine oxidases (PAOs). These enzymes differ to each other in substrate specificity, catalytic mechanism and subcellular localization. CuAOs and PAOs contribute to several physiological processes both through the control of polyamine homeostasis and as sources of biologically-active reaction products. CuAOs and PAOs have been found at high level in the cell-wall of several species belonging to Fabaceae and Poaceae families, respectively, especially in tissues fated to undertake extensive wall loosening/stiffening events and/or in cells undergoing programmed cell death (PCD). Apoplastic CuAOs and PAOs have been shown to play a key role as a source of H2O2 in light- or developmentally-regulated differentiation events, thus influencing cell-wall architecture and maturation as well as PCD. Moreover, growing evidence suggests a key role of intracellular CuAOs and PAOs in several facets of plant development. Here, we discuss recent advances in understanding the contribution of different CuAOs/PAOs, as well as their cross-talk with different intracellular and apoplastic metabolic pathways, in tissue differentiation and organ development.

  20. Swelling-activated ion channels: functional regulation in cell-swelling, proliferation and apoptosis

    DEFF Research Database (Denmark)

    Stutzin, A; Hoffmann, E K

    2006-01-01

    Cell volume regulation is one of the most fundamental homeostatic mechanisms and essential for normal cellular function. At the same time, however, many physiological mechanisms are associated with regulatory changes in cell size meaning that the set point for cell volume regulation is under phys...... as key players in the maintenance of normal steady-state cell volume, with particular emphasis on the intracellular signalling pathways responsible for their regulation during hypotonic stress, cell proliferation and apoptosis....

  1. The Cer-cqu gene cluster determines three key players in a β-diketone synthase polyketide pathway synthesizing aliphatics in epicuticular waxes

    DEFF Research Database (Denmark)

    Schneider, Lizette Marais; Adamski, Nikolai M.; Christensen, Caspar Elo;

    2016-01-01

    identification of mutants in their synthesis or transport. The present study discloses three such Eceriferum (cer) genes in barley - Cer-c, Cer-q and Cer-u - known to be tightly linked and functioning in a biochemical pathway forming dominating amounts of β-diketone and hydroxy-β-diketones plus some esterified...... five candidates, of which three were missing in apparent cer-cqu triple mutants. Sequencing more than 50 independent mutants for each gene confirmed their identification. Cer-c is a chalcone synthase-like polyketide synthase, designated diketone synthase (DKS), Cer-q is a lipase/carboxyl transferase...... affect overall protein structure or specific active site residues. The rich diversity of identified mutations will facilitate future studies of three key enzymes involved in synthesis of plant apoplast waxes....

  2. A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis.

    Science.gov (United States)

    Boualia, Sami Kamel; Gaitan, Yaned; Tremblay, Mathieu; Sharma, Richa; Cardin, Julie; Kania, Artur; Bouchard, Maxime

    2013-10-15

    Translating the developmental program encoded in the genome into cellular and morphogenetic functions requires the deployment of elaborate gene regulatory networks (GRNs). GRNs are especially crucial at the onset of organ development where a few regulatory signals establish the different programs required for tissue organization. In the renal system primordium (the pro/mesonephros), important regulators have been identified but their hierarchical and regulatory organization is still elusive. Here, we have performed a detailed analysis of the GRN underlying mouse pro/mesonephros development. We find that a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization. Among the genes directly affected by the core components are the key developmental molecules Nephronectin (Npnt) and Plac8. Hence, the pro/mesonephros GRN links together several essential genes regulating tissue morphogenesis. This renal GRN sheds new light on the disease group Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) in that gene mutations are expected to generate different phenotypic outcomes as a consequence of regulatory network deficiencies rather than threshold effects from single genes.

  3. The Cer-cqu gene cluster determines three key players in a β-diketone synthase polyketide pathway synthesizing aliphatics in epicuticular waxes

    Science.gov (United States)

    Schneider, Lizette M; Adamski, Nikolai M; Christensen, Caspar Elo; Stuart, David B; Vautrin, Sonia; Hansson, Mats; Uauy, Cristobal; von Wettstein-Knowles, Penny

    2016-01-01

    Aliphatic compounds on plant surfaces, called epicuticular waxes, are the first line of defense against pathogens and pests, contribute to reducing water loss and determine other important phenotypes. Aliphatics can form crystals affecting light refraction, resulting in a color change and allowing identification of mutants in their synthesis or transport. The present study discloses three such Eceriferum (cer) genes in barley – Cer-c, Cer-q and Cer-u – known to be tightly linked and functioning in a biochemical pathway forming dominating amounts of β-diketone and hydroxy-β-diketones plus some esterified alkan-2-ols. These aliphatics are present in many Triticeae as well as dicotyledons such as Eucalyptus and Dianthus. Recently developed genomic resources and mapping populations in barley defined these genes to a small region on chromosome arm 2HS. Exploiting Cer-c and -u potential functions pinpointed five candidates, of which three were missing in apparent cer-cqu triple mutants. Sequencing more than 50 independent mutants for each gene confirmed their identification. Cer-c is a chalcone synthase-like polyketide synthase, designated diketone synthase (DKS), Cer-q is a lipase/carboxyl transferase and Cer-u is a P450 enzyme. All were highly expressed in pertinent leaf sheath tissue of wild type. A physical map revealed the order Cer-c, Cer-u, Cer-q with the flanking genes 101kb apart, confirming they are a gene cluster, Cer-cqu. Homology-based modeling suggests that many of the mutant alleles affect overall protein structure or specific active site residues. The rich diversity of identified mutations will facilitate future studies of three key enzymes involved in synthesis of plant apoplast waxes. PMID:26962211

  4. The Cer-cqu gene cluster determines three key players in a β-diketone synthase polyketide pathway synthesizing aliphatics in epicuticular waxes.

    Science.gov (United States)

    Schneider, Lizette M; Adamski, Nikolai M; Christensen, Caspar Elo; Stuart, David B; Vautrin, Sonia; Hansson, Mats; Uauy, Cristobal; von Wettstein-Knowles, Penny

    2016-03-09

    Aliphatic compounds on plant surfaces, called epicuticular waxes, are the first line of defense against pathogens and pests, contribute to reducing water loss and determine other important phenotypes. Aliphatics can form crystals affecting light refraction, resulting in a color change and allowing identification of mutants in their synthesis or transport. The present study discloses three such Eceriferum (cer) genes in barley - Cer-c, Cer-q and Cer-u - known to be tightly linked and functioning in a biochemical pathway forming dominating amounts of β-diketone and hydroxy-β-diketones plus some esterified alkan-2-ols. These aliphatics are present in many Triticeae as well as dicotyledons such as Eucalyptus and Dianthus. Recently developed genomic resources and mapping populations in barley defined these genes to a small region on chromosome arm 2HS. Exploiting Cer-c and -u potential functions pinpointed five candidates, of which three were missing in apparent cer-cqu triple mutants. Sequencing more than 50 independent mutants for each gene confirmed their identification. Cer-c is a chalcone synthase-like polyketide synthase, designated diketone synthase (DKS), Cer-q is a lipase/carboxyl transferase and Cer-u is a P450 enzyme. All were highly expressed in pertinent leaf sheath tissue of wild type. A physical map revealed the order Cer-c, Cer-u, Cer-q with the flanking genes 101kb apart, confirming they are a gene cluster, Cer-cqu. Homology-based modeling suggests that many of the mutant alleles affect overall protein structure or specific active site residues. The rich diversity of identified mutations will facilitate future studies of three key enzymes involved in synthesis of plant apoplast waxes.

  5. Sequence/structural analysis of xylem proteome emphasizes pathogenesis-related proteins, chitinases and β-1, 3-glucanases as key players in grapevine defense against Xylella fastidiosa

    Directory of Open Access Journals (Sweden)

    Sandeep Chakraborty

    2016-05-01

    Full Text Available Background. Xylella fastidiosa, the causative agent of various plant diseases including Pierce’s disease in the US, and Citrus Variegated Chlorosis in Brazil, remains a continual source of concern and economic losses, especially since almost all commercial varieties are sensitive to this Gammaproteobacteria. Differential expression of proteins in infected tissue is an established methodology to identify key elements involved in plant defense pathways. Methods. In the current work, we developed a methodology named CHURNER that emphasizes relevant protein functions from proteomic data, based on identification of proteins with similar structures that do not necessarily have sequence homology. Such clustering emphasizes protein functions which have multiple copies that are up/down-regulated, and highlights similar proteins which are differentially regulated. As a working example we present proteomic data enumerating differentially expressed proteins in xylem sap from grapevines that were infected with X. fastidiosa. Results. Analysis of this data by CHURNER highlighted pathogenesis related PR-1 proteins, reinforcing this as the foremost protein function in xylem sap involved in the grapevine defense response to X. fastidiosa. β-1, 3-glucanase, which has both anti-microbial and anti-fungal activities, is also up-regulated. Simultaneously, chitinases are found to be both up and down-regulated by CHURNER, and thus the net gain of this protein function loses its significance in the defense response. Discussion. We demonstrate how structural data can be incorporated in the pipeline of proteomic data analysis prior to making inferences on the importance of individual proteins to plant defense mechanisms. We expect CHURNER to be applicable to any proteomic data set.

  6. Histone variants: key players of chromatin.

    Science.gov (United States)

    Biterge, Burcu; Schneider, Robert

    2014-06-01

    Histones are fundamental structural components of chromatin. Eukaryotic DNA is wound around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 promotes higher order chromatin organization. In addition to their structural role, histones impact chromatin function and dynamics by, e.g., post-translational histone modifications or the presence of specific histone variants. Histone variants exhibit differential expression timings (DNA replication-independent) and mRNA characteristics compared to canonical histones. Replacement of canonical histones with histone variants can affect nucleosome stability and help to create functionally distinct chromatin domains. In line with this, several histone variants have been implicated in the regulation of cellular processes such as DNA repair and transcriptional activity. In this review, we focus on recent progress in the study of core histone variants H2A.X, H2A.Z, macroH2A, H3.3, and CENP-A, as well as linker histone H1 variants, their functions and their links to development and disease.

  7. Glutathione: a key player in autoimmunity.

    Science.gov (United States)

    Perricone, Carlo; De Carolis, Caterina; Perricone, Roberto

    2009-07-01

    Increasing attention in the physiopathology of inflammatory/immunomediated diseases has been focused on the role of reactive oxygen species (ROS), oxygen-based molecules possessing high chemical reactivity and produced by activated neutrophils during the inflammatory response. During chronic inflammation, when sustained production of ROS occurs, antioxidant defences can weaken, resulting in a situation termed oxidative stress. Moreover, antioxidant defence systems have been demonstrated to be constitutively lacking in patients affected with chronic degenerative diseases, especially inflammatory/immunomediated. Glutathione, a tripeptide, is the principal component of the antioxidant defence system in the living cells. Glutathione has been demonstrated to have diverse effects on the immune system, either stimulating or inhibiting the immunological response in order to control inflammation. The study of interactions between glutathione and the immune system has attracted many investigators. Altered glutathione concentrations may play an important role in many autoimmune pathological conditions prevalently elicited, detrimed and maintained by inflammatory/immune response mediated by oxidative stress reactions. The role of glutathione in autoimmunity will be reviewed herein.

  8. Galectin-3: A key player in arthritis.

    Science.gov (United States)

    Hu, Yong; Yéléhé-Okouma, Mélissa; Ea, Hang-Korng; Jouzeau, Jean-Yves; Reboul, Pascal

    2017-01-01

    Arthritis is more and more considered as the leading reason for the disability in the world, particularly regarding its main entities, rheumatoid arthritis and osteoarthritis. The common feature of arthritis is inflammation, which is mainly supported by synovitis (synovial inflammation), although the immune system plays a primary role in rheumatoid arthritis and a secondary one in osteoarthritis. During the inflammatory phase of arthritis, many pro-inflammatory cytokines and mediators are secreted by infiltrating immune and resident joint cells, which are responsible for cartilage degradation and excessive bone remodeling. Amongst them, a β-galactoside-binding lectin, galectin-3, has been reported to be highly expressed and secreted by inflamed synovium of rheumatoid arthritis and osteoarthritis patients. Furthermore, galectin-3 has been demonstrated to induce joint swelling and osteoarthritis-like lesions after intra-articular injection in laboratory animals. However, the mechanisms underlying its pathophysiological role in arthritis have not been fully elucidated. This review deals with the characterization of arthritis features and galectin-3 and summarizes our current knowledge of the contribution of galectin-3 to joint tissue lesions in arthritis.

  9. TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response.

    Directory of Open Access Journals (Sweden)

    Dmitri Rozanov

    Full Text Available A high throughput screen for compounds that induce TRAIL-mediated apoptosis identified ML100 as an active chemical probe, which potentiated TRAIL activity in prostate carcinoma PPC-1 and melanoma MDA-MB-435 cells. Follow-up in silico modeling and profiling in cell-based assays allowed us to identify NSC130362, pharmacophore analog of ML100 that induced 65-95% cytotoxicity in cancer cells and did not affect the viability of human primary hepatocytes. In agreement with the activation of the apoptotic pathway, both ML100 and NSC130362 synergistically with TRAIL induced caspase-3/7 activity in MDA-MB-435 cells. Subsequent affinity chromatography and inhibition studies convincingly demonstrated that glutathione reductase (GSR, a key component of the oxidative stress response, is a target of NSC130362. In accordance with the role of GSR in the TRAIL pathway, GSR gene silencing potentiated TRAIL activity in MDA-MB-435 cells but not in human hepatocytes. Inhibition of GSR activity resulted in the induction of oxidative stress, as was evidenced by an increase in intracellular reactive oxygen species (ROS and peroxidation of mitochondrial membrane after NSC130362 treatment in MDA-MB-435 cells but not in human hepatocytes. The antioxidant reduced glutathione (GSH fully protected MDA-MB-435 cells from cell lysis induced by NSC130362 and TRAIL, thereby further confirming the interplay between GSR and TRAIL. As a consequence of activation of oxidative stress, combined treatment of different oxidative stress inducers and NSC130362 promoted cell death in a variety of cancer cells but not in hepatocytes in cell-based assays and in in vivo, in a mouse tumor xenograft model.

  10. Myeloid cell leukemia-1 is a key molecular target for mithramycin A-induced apoptosis in androgen-independent prostate cancer cells and a tumor xenograft animal model.

    Science.gov (United States)

    Choi, Eun-Sun; Jung, Ji-Youn; Lee, Jin-Seok; Park, Jong-Hwan; Cho, Nam-Pyo; Cho, Sung-Dae

    2013-01-01

    Mithramycin A (Mith) is a natural polyketide that has been used in multiple areas of research including apoptosis of various cancer cells. Here, we examined the critical role of Mith in apoptosis and its molecular mechanism in DU145 and PC3 prostate cancer cells and tumor xenografts. Mith decreased cell growth and induced apoptosis in DU145 and PC-3 cells. Myeloid cell leukemia-1 (Mcl-1) was over-expressed in both cell lines compared to RWPE1 cells. Mith inhibited Mcl-1 protein expression in both cells, but only altered Mcl-1 mRNA levels in PC-3 cells. We also found that Mith reduced Mcl-1 protein levels through both proteasome-dependent protein degradation and the inhibition of protein synthesis in DU145 cells. Studies using siRNA confirmed that the knockdown of Mcl-1 induced apoptosis. Mith significantly suppressed TPA-induced neoplastic cell transformation through the down-regulation of the Mcl-1 protein in JB6 cells, and suppressed the transforming activity of both cell types. Mith also inhibited tumor growth and Mcl-1 levels, in addition to inducing apoptosis, in athymic nude mice bearing DU145 cell xenografts without affecting five normal organs. Therefore, Mith inhibits cell growth and induces apoptosis by suppressing Mcl-1 in both prostate cancer cells and xenograft tumors, and thus is a potent anticancer drug candidate for prostate cancer.

  11. EVALUATING AUSTRALIAN FOOTBALL LEAGUE PLAYER CONTRIBUTIONS USING INTERACTIVE NETWORK SIMULATION

    Directory of Open Access Journals (Sweden)

    Jonathan Sargent

    2013-03-01

    Full Text Available This paper focuses on the contribution of Australian Football League (AFL players to their team's on-field network by simulating player interactions within a chosen team list and estimating the net effect on final score margin. A Visual Basic computer program was written, firstly, to isolate the effective interactions between players from a particular team in all 2011 season matches and, secondly, to generate a symmetric interaction matrix for each match. Negative binomial distributions were fitted to each player pairing in the Geelong Football Club for the 2011 season, enabling an interactive match simulation model given the 22 chosen players. Dynamic player ratings were calculated from the simulated network using eigenvector centrality, a method that recognises and rewards interactions with more prominent players in the team network. The centrality ratings were recorded after every network simulation and then applied in final score margin predictions so that each player's match contribution-and, hence, an optimal team-could be estimated. The paper ultimately demonstrates that the presence of highly rated players, such as Geelong's Jimmy Bartel, provides the most utility within a simulated team network. It is anticipated that these findings will facilitate optimal AFL team selection and player substitutions, which are key areas of interest to coaches. Network simulations are also attractive for use within betting markets, specifically to provide information on the likelihood of a chosen AFL team list "covering the line".

  12. The Player Engagement Process

    DEFF Research Database (Denmark)

    Schoenau-Fog, Henrik

    2011-01-01

    Engagement is an essential element of the player experience, and the concept is described in various ways in the literature. To gain a more detailed comprehension of this multifaceted concept, and in order to better understand what aspects can be used to evaluate engaging game play and to design...... engaging user experiences, this study investigates one dimension of player engagement by empirically identifying the components associated with the desire to continue playing. Based on a description of the characteristics of player engagement, a series of surveys were developed to discover the components......, categories and triggers involved in this process. By applying grounded theory to the analysis of the responses, a process-oriented player engagement framework was developed and four main components consisting of objectives, activities, accomplishments and affects as well as the corresponding categories...

  13. Cardiovascular molecular imaging of apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Wolters, S.L.; Reutelingsperger, C.P.M. [Maastricht University, Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht (Netherlands); Corsten, M.F.; Hofstra, L. [Maastricht University, Department of Cardiology, Cardiovascular Research Institute Maastricht, P.O. Box 616, Maastricht (Netherlands); Narula, J. [University of California Irvine, Department of Cardiology, Irvine (United States)

    2007-06-15

    Molecular imaging strives to visualise processes at the molecular and cellular level in vivo. Understanding these processes supports diagnosis and evaluation of therapeutic efficacy on an individual basis and thereby makes personalised medicine possible. Apoptosis is a well-organised mode of cell suicide that plays a role in cardiovascular diseases (CVD). Apoptosis is associated with loss of cardiomyocytes following myocardial infarction, atherosclerotic plaque instability, congestive heart failure and allograft rejection of the transplanted heart. Thus, apoptosis constitutes an attractive target for molecular imaging of CVD. Our current knowledge about the molecular players and mechanisms underlying apoptosis offers a rich palette of potential molecular targets for molecular imaging. However, only a few have been successfully developed so far. This review highlights aspects of the molecular machinery and biochemistry of apoptosis relevant to the development of molecular imaging probes. It surveys the role of apoptosis in four major areas of CVD and portrays the importance and future perspectives of apoptosis imaging. The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies. (orig.)

  14. Cricket club looking for new players

    CERN Multimedia

    Cricket Club

    2016-01-01

    The CERN Cricket Club, having lost several key players, has had a very difficult season so far and is desperately in need of new players. Having qualified for the Cricket Switzerland semi-finals for the last two years (unfortunately losing both), this year we are bottom of the Western Pool, having played the last two league matches with only 10 players. If you are interested in playing cricket please join us at net practice, which takes place on the Prevessin site each Thursday evening from 18:00 to around 20:00 (weather permitting) or send me an e-mail (see below). Please have a look at the Cricket Club web site for more information: http://cern.ch/Club-Cricket/ Chris Onions, President of the CERN Cricket Club   (christopher.onions@gmail.com)

  15. Balance between apoptosis or survival induced by changes in extracellular-matrix composition in human mesangial cells: a key role for ILK-NFκB pathway.

    Science.gov (United States)

    del Nogal, María; Luengo, Alicia; Olmos, Gemma; Lasa, Marina; Rodriguez-Puyol, Diego; Rodriguez-Puyol, Manuel; Calleros, Laura

    2012-12-01

    Renal fibrosis is the final outcome of many clinical conditions that lead to chronic renal failure, characterized by a progressive substitution of cellular elements by extracellular-matrix proteins, in particular collagen type I. The aim of this study was to identify the mechanisms responsible for human mesangial cell survival, conditioned by changes in extracellular-matrix composition. Our results indicate that collagen I induces apoptosis in cells but only after inactivation of the pro-survival factor NFκB by either the super-repressor IκBα or the PDTC inhibitor. Collagen I activates a death pathway, through ILK/GSK-3β-dependent Bim expression. Moreover, collagen I significantly increases NFκB-dependent transcription, IκBα degradation and p65/NFκB translocation to the nucleus; it activates β1 integrin and this is accompanied by increased activity of ILK which leads to AKT activation. Knockdown of ILK or AKT with small interfering RNA suppresses the increase in NFκB activity. NFκB mediates cell survival through the antiapoptotic protein Bcl-xL. Our data suggest that human mesangial cells exposed to abnormal collagen I are protected against apoptosis by a complex mechanism involving integrin β1/ILK/AKT-dependent NFκB activation with consequent Bcl-xL overexpression, that opposes a simultaneously activated ILK/GSK-3β-dependent Bim expression and this dual mechanism may play a role in the progression of glomerular dysfunction.

  16. Triggering of dendritic cell apoptosis by xanthohumol.

    Science.gov (United States)

    Xuan, Nguyen Thi; Shumilina, Ekaterina; Gulbins, Erich; Gu, Shuchen; Götz, Friedrich; Lang, Florian

    2010-07-01

    Xanthohumol, a flavonoid from beer with anticancer activity is known to trigger apoptosis in a variety of tumor cells. Xanthohumol further has anti-inflammatory activity. However, little is known about the effect of xanthohumol on survival and function of immune cells. The present study thus addressed the effect of xanthohumol on dendritic cells (DCs), key players in the regulation of innate and adaptive immunity. To this end, mouse bone marrow-derived DCs were treated with xanthohumol with subsequent assessment of enzymatic activity of acid sphingomyelinase (Asm), ceramide formation determined with anti-ceramide antibodies in FACS and immunohistochemical analysis, caspase activity utilizing FITC conjugated anti-active caspase 8 or caspase 3 antibodies in FACS and by Western blotting, DNA fragmentation by determining the percentage of cells in the sub-G1 phase and cell membrane scrambling by annexin V binding in FACS analysis. As a result, xanthohumol stimulated Asm, enhanced ceramide formation, activated caspases 8 and 3, triggered DNA fragmentation and led to cell membrane scrambling, all effects virtually absent in DCs from gene targeted mice lacking functional Asm or in wild-type cells treated with sphingomyelinase inhibitor amitriptyline. In conclusion, xanthohumol stimulated Asm leading to caspase activation and apoptosis of bone marrow-derived DCs.

  17. Carbon ion beam triggers both caspase-dependent and caspase-independent pathway of apoptosis in HeLa and status of PARP-1 controls intensity of apoptosis.

    Science.gov (United States)

    Ghorai, Atanu; Sarma, Asitikantha; Bhattacharyya, Nitai P; Ghosh, Utpal

    2015-04-01

    High linear energy transfer (LET) carbon ion beam (CIB) is becoming very promising tool for various cancer treatments and is more efficient than conventional low LET gamma or X-rays to kill malignant or radio-resistant cells, although detailed mechanism of cell death is still unknown. Poly (ADP-ribose) polymerase-1 (PARP-1) is a key player in DNA repair and its inhibitors are well-known as radio-sensitizer for low LET radiation. The objective of our study was to find mechanism(s) of induction of apoptosis by CIB and role of PARP-1 in CIB-induced apoptosis. We observed overall higher apoptosis in PARP-1 knocked down HeLa cells (HsiI) compared with negative control H-vector cells after irradiation with CIB (0-4 Gy). CIB activated both intrinsic and extrinsic pathways of apoptosis via caspase-9 and caspase-8 activation respectively, followed by caspase-3 activation, apoptotic body, nucleosomal ladder formation and sub-G1 accumulation. Apoptosis inducing factor translocation into nucleus in H-vector but not in HsiI cells after CIB irradiation contributed caspase-independent apoptosis. Higher p53 expression was observed in HsiI cells compared with H-vector after exposure with CIB. Notably, we observed about 37 % fall of mitochondrial membrane potential, activation of caspase-9 and caspase-3 and mild activation of caspase-8 without any detectable apoptotic body formation in un-irradiated HsiI cells. We conclude that reduction of PARP-1 expression activates apoptotic signals via intrinsic and extrinsic pathways in un-irradiated cells. CIB irradiation further intensified both intrinsic and extrinsic pathways of apoptosis synergistically along with up-regulation of p53 in HsiI cells resulting overall higher apoptosis in HsiI than H-vector.

  18. Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells.

    Directory of Open Access Journals (Sweden)

    Loubna Abdel Hadi

    Full Text Available The plant flavonoid luteolin exhibits different biological effects, including anticancer properties. Little is known on the molecular mechanisms underlying its actions in colorectal cancer (CRC. Here we investigated the effects of luteolin on colon cancer cells, focusing on the balance between ceramide and sphingosine-1-phosphate (S1P, two sphingoid mediators with opposite roles on cell fate. Using cultured cells, we found that physiological concentrations of luteolin induce the elevation of ceramide, followed by apoptotic death of colon cancer cells, but not of differentiated enterocytes. Pulse studies revealed that luteolin inhibits ceramide anabolism to complex sphingolipids. Further experiments led us to demonstrate that luteolin induces an alteration of the endoplasmic reticulum (ER-Golgi flow of ceramide, pivotal to its metabolic processing to complex sphingolipids. We report that luteolin exerts its action by inhibiting both Akt activation, and sphingosine kinase (SphK 2, with the consequent reduction of S1P, an Akt stimulator. S1P administration protected colon cancer cells from luteolin-induced apoptosis, most likely by an intracellular, receptor-independent mechanism. Overall this study reveals for the first time that the dietary flavonoid luteolin exerts toxic effects on colon cancer cells by inhibiting both S1P biosynthesis and ceramide traffic, suggesting its dietary introduction/supplementation as a potential strategy to improve existing treatments in CRC.

  19. Microparticles as players in the pathogenesis of cardiovascular disease

    Energy Technology Data Exchange (ETDEWEB)

    Alexandru, N.; Georgescu, A.

    2015-07-01

    Cardiovascular diseases (CVD) are the largest cause of morbidity and mortality in the world and include all diseases and conditions of the heart and blood vessels. The main cause of most CVD is atherosclerosis, which is an abnormal build-up of fat and other substances which form plaque inside the arteries. Atherosclerosis is most serious when it leads to reduced or blocked blood supply to the heart (causing angina or heart attack) or to the brain (causing a stroke). The majority of CVD is caused by risk factors that can be controlled, treated or modified. Microparticles (MPs) are now recognized as potential biomarkers and key elements in the development of CVD. Although MP generation is a physiological phenomenon, their shedding from a variety of cell types into body fluid is intensified in response to cellular activation, high shear stress, as well as cellular apoptosis. In this review we outline distinct aspect of MP generation and their side as players n the CVD development.

  20. Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration.

    Science.gov (United States)

    Murakami, Y; Matsumoto, H; Roh, M; Giani, A; Kataoka, K; Morizane, Y; Kayama, M; Thanos, A; Nakatake, S; Notomi, S; Hisatomi, T; Ikeda, Y; Ishibashi, T; Connor, K M; Miller, J W; Vavvas, D G

    2014-02-01

    There is no known treatment for the dry form of an age-related macular degeneration (AMD). Cell death and inflammation are important biological processes thought to have central role in AMD. Here we show that receptor-interacting protein (RIP) kinase mediates necrosis and enhances inflammation in a mouse model of retinal degeneration induced by dsRNA, a component of drusen in AMD. In contrast to photoreceptor-induced apoptosis, subretinal injection of the dsRNA analog poly(I : C) caused necrosis of the retinal pigment epithelium (RPE), as well as macrophage infiltration into the outer retinas. In Rip3(-/-) mice, both necrosis and inflammation were prevented, providing substantial protection against poly(I : C)-induced retinal degeneration. Moreover, after poly(I : C) injection, Rip3(-/-) mice displayed decreased levels of pro-inflammatory cytokines (such as TNF-α and IL-6) in the retina, and attenuated intravitreal release of high-mobility group box-1 (HMGB1), a major damage-associated molecular pattern (DAMP). In vitro, poly(I : C)-induced necrosis were inhibited in Rip3-deficient RPE cells, which in turn suppressed HMGB1 release and dampened TNF-α and IL-6 induction evoked by necrotic supernatants. On the other hand, Rip3 deficiency did not modulate directly TNF-α and IL-6 production after poly(I : C) stimulation in RPE cells or macrophages. Therefore, programmed necrosis is crucial in dsRNA-induced retinal degeneration and may promote inflammation by regulating the release of intracellular DAMPs, suggesting novel therapeutic targets for diseases such as AMD.

  1. Implementation of Mobile Streaming Media Player Based on BREW

    Institute of Scientific and Technical Information of China (English)

    WANG Zhong-rong; LIU Zhao

    2006-01-01

    Nowadays mobile streaming service through cell phone is becoming the highlight of new value-added mobile services. Based on the present CDMA1x wireless data network and Binary Runtime Environment for Wireless (BREW) platform, adopting compression technologies of H.264 and QCP, a set of streaming media players are designed and implemented, and the principle, structure, key technologies and performance analysis of this system are introduced. This player works well in practice.

  2. Role of Calpain in Apoptosis

    Directory of Open Access Journals (Sweden)

    Hamid Reza Momeni

    2011-01-01

    Full Text Available Apoptosis, a form of programmed cell death that occurs under physiologicalas well as pathological conditions, is characterized by morphological and biochemicalfeatures. While the importance of caspases in apoptosis is established,several noncaspase proteases (Ca2+-dependent proteases such as calpain mayplay a role in the execution of apoptosis. The calpain family consists of twomajor isoforms, calpain I and calpain II which require μM and mM Ca2+ concentrationsto initiate their activity. An increase in intracellular Ca2+ level isthought to trigger a cascade of biochemical processes including calpain activation.Once activated, calpains degrade membrane, cytoplasmic and nuclear substrates,leading to the breakdown of cellular architecture and finally apoptosis.The activation of calpain has been implicated in neuronal apoptosis followingspinal cord injuries and neurodegenerative diseases. This review focuses oncalpain with an emphasis on its key role in the proteolysis of cellular proteinsubstrates following apoptosis.

  3. How to Share a Key (Invited paper)

    DEFF Research Database (Denmark)

    Fitzi, Matthias; Nielsen, Jesper Buus; Wolf, Stefan

    The problem of asynchronous perfectly secure communication via one-time pads (OTP) has been recently introduced by Di Crescenzo and Kiayias. There, several players share the same OTP to be used in parallel but it is not known in advance which players will consume how many bits of the pad. Based...... players to share the same k keys of length ` bits. The goal is to assign a key sequence to each player such that, for as many keys as possible and independently of which player uses how many of them, it is guaranteed that all used keys are independent. Such an assignment is called loss-free if k keys can...... always be consumed independently. Note that, in contrast to the previous model, the players are ignorant of each other’s key consumptions. We first observe a simple loss-free solution for the case that the key is of certain (small) minimal length `. Furthermore, for the case of key length ` = 1 (the most...

  4. Multi-Player Quantum Games

    CERN Document Server

    Benjamin, S C; Benjamin, Simon C.; Hayden, Patrick M.

    2001-01-01

    Game theory is a mature field of applied mathematics. It formalizes the conflict between competing agents, and has found applications ranging from economics through to biology. Recently the first efforts have been made to introduce quantum information into game theory. For two-player games, it has been found that when the allowed `moves' are extended to include everything quantum mechanically possible, then the predominant strategies in the game can disappear, and only reappear if the players degrade the quantum coherence. Here we present the first study of quantum games with more than two players. We demonstrate that such games can exhibit `coherent' equilibrium strategies which have no analogue in classical games, or even in two-player quantum games. These equilibria are generally of a cooperative nature: quantum players can exploit their environment highly efficiently through the use of collaborative strategies.

  5. Predicting Player Churn In the Wild

    DEFF Research Database (Denmark)

    Hadiji, Fabian; Sifa, Rafet; Drachen, Anders;

    2014-01-01

    a crucial value, allowing developers to obtain data-driven insights to inform design, development and marketing strategies. One of the key challenges is modeling and predicting player churn. This paper presents the first cross-game study of churn prediction in Free-to-Play games. Churn in games is discussed...... with the individual retention model for each game in the dataset used, we develop a broadly applicable churn prediction model, which does not rely on gamedesign specific features. The presented classifiers are applied on a dataset covering five free-to-play games resulting in high accuracy churn prediction....

  6. The Edubox Learning Design Player

    NARCIS (Netherlands)

    Tattersall, Colin; Vogten, Hubert; Hermans, Henry

    2005-01-01

    Tattersall, C., Vogten, H. & Hermans, H. (2005). The Edubox Learning Design Player. In: Koper, R. & Tattersall, C., Learning Design: A Handbook on Modelling and Delivering Networked Education and Training (pp. 303-310). Berlin-Heidelberg: Springer Verlag.

  7. CUEDC2: an emerging key player in inflammation and tumorigenesis

    Institute of Scientific and Technical Information of China (English)

    Jianghong Man; Xuemin Zhang

    2011-01-01

    CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle,inflammation,and tumorigenesis and is highly expressed in many types of tumors.CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibition.CUEDC2 is also known to interact with IkB kinase α (IKKα) and IKKβ and has an inhibitory role in the activation of transcription factor nuclear factor-κB.Moreover,CUEDC2 plays an important role in downregulating the expression of hormone receptors estrogen receptorα and progesterone receptor,thereby impairing the responsiveness of breast cancer to endocrine therapies.In this review,current knowledge on the multi-functions of CUEDC2 in normal processes and tumorigenesis are discussed and summarized.

  8. ROS as key players in plant stress signalling.

    Science.gov (United States)

    Baxter, Aaron; Mittler, Ron; Suzuki, Nobuhiro

    2014-03-01

    Reactive oxygen species (ROS) play an integral role as signalling molecules in the regulation of numerous biological processes such as growth, development, and responses to biotic and/or abiotic stimuli in plants. To some extent, various functions of ROS signalling are attributed to differences in the regulatory mechanisms of respiratory burst oxidase homologues (RBOHs) that are involved in a multitude of different signal transduction pathways activated in assorted tissue and cell types under fluctuating environmental conditions. Recent findings revealed that stress responses in plants are mediated by a temporal-spatial coordination between ROS and other signals that rely on production of stress-specific chemicals, compounds, and hormones. In this review we will provide an update of recent findings related to the integration of ROS signals with an array of signalling pathways aimed at regulating different responses in plants. In particular, we will address signals that confer systemic acquired resistance (SAR) or systemic acquired acclimation (SAA) in plants.

  9. Key players must help shatter the glass ceiling, say experts.

    Science.gov (United States)

    Eubanks, P

    1991-10-01

    Women are continuing to move up through the management pipeline in hospitals across the country; but is top management prepared? Although many women are aiming for the highest levels in management, a recent survey of female and male health care executives indicates that critical changes must be made by top management and boards of hospitals before those women can continue to advance accordingly. Meanwhile, women's experience as senior executives has been quite different from men's, the survey also shows.

  10. Microbial Ecology of Anaerobic Digesters: The Key Players of Anaerobiosis

    Science.gov (United States)

    Ali Shah, Fayyaz; Mahmood, Qaisar; Maroof Shah, Mohammad; Pervez, Arshid; Ahmad Asad, Saeed

    2014-01-01

    Anaerobic digestion is the method of wastes treatment aimed at a reduction of their hazardous effects on the biosphere. The mutualistic behavior of various anaerobic microorganisms results in the decomposition of complex organic substances into simple, chemically stabilized compounds, mainly methane and CO2. The conversions of complex organic compounds to CH4 and CO2 are possible due to the cooperation of four different groups of microorganisms, that is, fermentative, syntrophic, acetogenic, and methanogenic bacteria. Microbes adopt various pathways to evade from the unfavorable conditions in the anaerobic digester like competition between sulfate reducing bacteria (SRB) and methane forming bacteria for the same substrate. Methanosarcina are able to use both acetoclastic and hydrogenotrophic pathways for methane production. This review highlights the cellulosic microorganisms, structure of cellulose, inoculum to substrate ratio, and source of inoculum and its effect on methanogenesis. The molecular techniques such as DGGE (denaturing gradient gel electrophoresis) utilized for dynamic changes in microbial communities and FISH (fluorescent in situ hybridization) that deal with taxonomy and interaction and distribution of tropic groups used are also discussed. PMID:24701142

  11. Fibroblast growth factor 21 - a key player in cardiovascular disorders?

    Science.gov (United States)

    Lenart-Lipińska, Monika; Duma, Dariusz; Hałabiś, Magdalena; Dziedzic, Marcin; Solski, Janusz

    2016-06-15

    Fibroblast growth factor 21 (FGF21) is a newly discovered adipokine, synthesized by several organs, mostly by the liver, which was introduced as a potent metabolic regulator and insulin-sensitizing factor. Numerous animal studies have demonstrated that FGF21 improves glucose and lipids metabolism and exerts anti-inflammatory effects. However, data obtained from human studies have shown contradictory results, in which circulating FGF21 levels were often elevated in obesity, dyslipidemia, type 2 diabetes (DM2) and other conditions connected with insulin resistance. This increase in basal FGF21 concentrations observed in patients with obesity and other conditions related to insulin resistance was being explained as a compensatory response to the underlying metabolic disturbances or tissue resistance to FGF21 action. Furthermore, the results of clinical trials have shown that increased FGF21 concentrations were associated with increased cardiovascular (CV) risk and had a prognostic value in CV outcomes. In recent years, it has been reported that FGF21 may exert cardioprotective effects. This mini-review aims to summarize the current state of knowledge about the role of FGF21 in CV disorders, and discuss the molecular mechanism underlying the anti-atherogenic properties of this compound.

  12. Training Teachers as Key Players in Poverty Alleviation

    Science.gov (United States)

    Benavente, Ana; Ralambomanana, Stangeline; Mbanze, Jorge

    2008-01-01

    This article presents several questions, reflections and suggestions on pre-service and in-service teacher training that arose during the project "Curricular innovation and poverty alleviation in sub-Saharan Africa". While recognizing that the situation in the nine countries taking part in the project, and in many other countries in the southern…

  13. Microbial Ecology of Anaerobic Digesters: The Key Players of Anaerobiosis

    Directory of Open Access Journals (Sweden)

    Fayyaz Ali Shah

    2014-01-01

    Full Text Available Anaerobic digestion is the method of wastes treatment aimed at a reduction of their hazardous effects on the biosphere. The mutualistic behavior of various anaerobic microorganisms results in the decomposition of complex organic substances into simple, chemically stabilized compounds, mainly methane and CO2. The conversions of complex organic compounds to CH4 and CO2 are possible due to the cooperation of four different groups of microorganisms, that is, fermentative, syntrophic, acetogenic, and methanogenic bacteria. Microbes adopt various pathways to evade from the unfavorable conditions in the anaerobic digester like competition between sulfate reducing bacteria (SRB and methane forming bacteria for the same substrate. Methanosarcina are able to use both acetoclastic and hydrogenotrophic pathways for methane production. This review highlights the cellulosic microorganisms, structure of cellulose, inoculum to substrate ratio, and source of inoculum and its effect on methanogenesis. The molecular techniques such as DGGE (denaturing gradient gel electrophoresis utilized for dynamic changes in microbial communities and FISH (fluorescent in situ hybridization that deal with taxonomy and interaction and distribution of tropic groups used are also discussed.

  14. Key players in pancreatic cancer-stroma interaction

    DEFF Research Database (Denmark)

    Nielsen, Michael Friberg Bruun; Mortensen, Michael Bau; Detlefsen, Sönke

    2016-01-01

    of this review is to describe the complex interplay between PC cells and the cellular and non-cellular components of the tumour stroma. Published data have indicated that the desmoplastic stroma protects PC cells against chemotherapy and radiation therapy and that it might promote the proliferation and migration...

  15. Brokers and key players in the internationalization of the FARC

    OpenAIRE

    Cunningham, Dan; Everton, Sean; Wilson, Greg; Padilla, Carlos; Zimmerman, Doug

    2013-01-01

    The article of records as published may be located at http://dx.doi.org/10.1080/1057610X.2013.784603 The Fuerzas Armadas Revolucionarias de Colombia (Revolutionary Armed Forces of Colombia—FARC) was originally founded to protect Colombian peasants from harsh landowner policies in exchange for food and supplies. Over time, it has evolved into an internationally connected, narco-trafficking organization that displays little concern for the peasants it once vowed to protect. In re...

  16. Protein phosphatase 2A, a key player in Alzheimer's disease

    Institute of Scientific and Technical Information of China (English)

    Rong LIU; Qing TIAN

    2009-01-01

    Protein phosphatase 2A (PP2A) is the pre-dominant serine/threonine phosphatase in eukaryotic cells. In the brains of patients with Alzheimer's disease (AD), decreased PP2A activities were observed, which is suggested to be involved in neurofibrillary tangle (NFT) formation, disturbed amyloid precursor protein (APP) secretion and neurodegeneration in AD brain. Based on our research and other previous findings, decreased PP2Ac level, decreased PP2A holoenzyme composition, increased level of PP2A inhibitors, increased PP2Ac Leu309 demethylation and Tyr307 phosphorylation underlie PP2A inactivation in AD. β-amyloid (Aβ) over-production, estrogen deficiency and impaired homocys-teine metabolism are the possible up-stream factors that inactivate PP2A in AD neurons. Further studies are required to disclose the role of PP2A in Alzheimer's disease.

  17. The HBZ gene, a key player in HTLV-1 pathogenesis

    Directory of Open Access Journals (Sweden)

    Green Patrick L

    2009-08-01

    Full Text Available Abstract Human T-cell leukemia virus type 1 (HTLV-1 causes adult T-cell leukemia/lymphoma (ATL and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.

  18. The proximal tubular cell, a key player in renal damage

    NARCIS (Netherlands)

    Timmeren, Mirjan Miranda van

    2008-01-01

    A decline in renal function is associated with the degree of proteinuria and with histological findings of glomerulosclerosis and interstitial fibrosis. Proteinuria is not only a marker of renal damage, but ultrafiltered proteins can be toxic to the kidney, thereby contributing to tubulo-interstitia

  19. Mitochondria: key players in the neurotoxic effects of amphetamines.

    Science.gov (United States)

    Barbosa, Daniel José; Capela, João Paulo; Feio-Azevedo, Rita; Teixeira-Gomes, Armanda; Bastos, Maria de Lourdes; Carvalho, Félix

    2015-10-01

    Amphetamines are a class of psychotropic drugs with high abuse potential, as a result of their stimulant, euphoric, emphathogenic, entactogenic, and hallucinogenic properties. Although most amphetamines are synthetic drugs, of which methamphetamine, amphetamine, and 3,4-methylenedioxymethamphetamine ("ecstasy") represent well-recognized examples, the use of natural related compounds, namely cathinone and ephedrine, has been part of the history of humankind for thousands of years. Resulting from their amphiphilic nature, these drugs can easily cross the blood-brain barrier and elicit their well-known psychotropic effects. In the field of amphetamines' research, there is a general consensus that mitochondrial-dependent pathways can provide a major understanding concerning pathological processes underlying the neurotoxicity of these drugs. These events include alterations on tricarboxylic acid cycle's enzymes functioning, inhibition of mitochondrial electron transport chain's complexes, perturbations of mitochondrial clearance mechanisms, interference with mitochondrial dynamics, as well as oxidative modifications in mitochondrial macromolecules. Additionally, other studies indicate that amphetamines-induced neuronal toxicity is closely regulated by B cell lymphoma 2 superfamily of proteins with consequent activation of caspase-mediated downstream cell death pathway. Understanding the molecular mechanisms at mitochondrial level involved in amphetamines' neurotoxicity can help in defining target pathways or molecules mediating these effects, as well as in developing putative therapeutic approaches to prevent or treat the acute- or long-lasting neuropsychiatric complications seen in human abusers.

  20. Mineralocorticoid receptor in human brain : a key player in resilience

    NARCIS (Netherlands)

    Klok, Melanie Diane

    2011-01-01

    Depression involves multiple mental problems, including low mood, inability to experience pleasure and emotional, cognitive and behavioral problems. It has a lifetime prevalence of ~15% in the Dutch population, striking women twice as often as men. The disorder often comprises persisting disturbance

  1. The endocannabinoid system: an emerging key player in inflammation

    NARCIS (Netherlands)

    Witkamp, R.F.; Meijerink, J.

    2014-01-01

    Purpose of review: The purpose of this review is to illustrate the expanding view of the endocannabinoid system (ECS) in relation to its roles in inflammation. Recent findings: According to the formal classification, the ECS consists of two cannabinoid receptors, their endogenous fatty acid-derived

  2. Weighted Key Player Problem for Social Network Analysis

    Science.gov (United States)

    2011-03-01

    that can be found at http://www.python.org. This code makes use of a number of free and open source Python packages: SciPy, NumPy and NetworkX...each partition , a list partition: The p paritions of the network , a dictionary ’’’ import networkx as nx 226 import numpy from scipy.cluster import

  3. Frontal Lobe Function in Chess Players

    Directory of Open Access Journals (Sweden)

    Vahid Nejati

    2012-05-01

    Full Text Available Chess is considered as a cognitive game because of severe engagement of the mental resources during playing. The purpose of this study is evaluation of frontal lobe function of chess players with matched non-players. Wisconsin Card Sorting Test (WCST data showed no difference between the player and non-player groups in preservation error and completed categories but surprisingly showed significantly lower grade of the player group in correct response. Our data reveal that chess players dont have any preference in any stage of Stroop test. Chess players dont have any preference in selective attention, inhibition and executive cognitive function. Chess players' have lower shifting abilities than non-players.

  4. MEANING TO BE VOLLEYBALL PLAYER IN CAREER TRANSITION PHASE

    Directory of Open Access Journals (Sweden)

    Adriana Justino

    2016-09-01

    Full Text Available The objective of this study is to assess the meaning of being that a volleyball player for the under-19 players who are experiencing a transition in their in career. Sixteen male players aged 17 and 18 were evaluated, by being asked the triggering question “What does being a volleyball player mean to you?” The analysis of the discourses was carried out according to the procedures recommended by Miles & Huberman (2004. Four response categories resulted: psychoemotional and behavioral skills, emotions in sport, recognition and financial return, skills as an athlete/player. The athletes showed that the meaning of sport lies especially in the passion for practice, but also, in the improving of their tactics and techniques, in the development of psychoemotional and behavioral skills, in the professional recognition and, to a lesser degree, in the financial aspect. Most athletes state they intend to continue in the juvenile sports categories, therefore, understanding the meaning of this activity in their life can be the key to the elaboration of a plan of psychological preparation whose aim is to provide support to their needs in this moment of professional choice.

  5. Integrin-Associated Focal Adhesion Kinase Protects Human Embryonic Stem Cells from Apoptosis, Detachment, and Differentiation

    Directory of Open Access Journals (Sweden)

    Loriana Vitillo

    2016-08-01

    Full Text Available Human embryonic stem cells (hESCs can be maintained in a fully defined niche on extracellular matrix substrates, to which they attach through integrin receptors. However, the underlying integrin signaling mechanisms, and their contribution to hESC behavior, are largely unknown. Here, we show that focal adhesion kinase (FAK transduces integrin activation and supports hESC survival, substrate adhesion, and maintenance of the undifferentiated state. After inhibiting FAK kinase activity we show that hESCs undergo cell detachment-dependent apoptosis or differentiation. We also report deactivation of FAK downstream targets, AKT and MDM2, and upregulation of p53, all key players in hESC regulatory networks. Loss of integrin activity or FAK also induces cell aggregation, revealing a role in the cell-cell interactions of hESCs. This study provides insight into the integrin signaling cascade activated in hESCs and reveals in FAK a key player in the maintenance of hESC survival and undifferentiated state.

  6. Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NFκβ pathways.

    Science.gov (United States)

    Harsha Raj, M; Yashaswini, B; Rössler, Jochen; Salimath, Bharathi P

    2016-05-01

    TRAIL, an apoptosis inducing cytokine currently in phase II clinical trial, was investigated for its capability to induce apoptosis in six different human tumor cell lines out of which three cell lines showed resistance to TRAIL induced apoptosis. To investigate whether Anacardic acid (A1) an active component of Anacardium occidentale can sensitize the resistant cell lines to TRAIL induced apoptosis, we treated the resistant cells with suboptimal concentration of A1 and showed that it is a potent enhancer of TRAIL induced apoptosis which up-regulates the expression of both DR4 and DR5 receptors, which has been observed in the cellular, protein and mRNA levels. The death receptors upregulation consequent to A1 treatment was corroborated by the activation of p53 as well as phosphorylation of p38 and JNK MAP kinases and concomitant inactivation of NFκβ and ERK signaling cascades. Also, A1 modulated the expression of key apoptotic players like Bax, Bcl-2 and CAD along with the abatement of tumor angiogenesis in vivo in EAT mouse model. Thus, post A1 treatment the TRAIL resistant cells turned into TRAIL sensitive cells. Hence our results demonstrate that A1 can synergize TRAIL induced apoptosis through the upregulation of death receptors and downregulation of anti-apoptotic proteins in cancer context.

  7. Mycobacterium tuberculosis effectors interfering host apoptosis signaling.

    Science.gov (United States)

    Liu, Minqiang; Li, Wu; Xiang, Xiaohong; Xie, Jianping

    2015-07-01

    Tuberculosis remains a serious human public health concern. The coevolution between its pathogen Mycobacterium tuberculosis and human host complicated the way to prevent and cure TB. Apoptosis plays subtle role in this interaction. The pathogen endeavors to manipulate the apoptosis via diverse effectors targeting key signaling nodes. In this paper, we summarized the effectors pathogen used to subvert the apoptosis, such as LpqH, ESAT-6/CFP-10, LAMs. The interplay between different forms of cell deaths, such as apoptosis, autophagy, necrosis, is also discussed with a focus on the modes of action of effectors, and implications for better TB control.

  8. The Effectiveness Evaluation among Different Player-Matching Mechanisms in a Multi-Player Quiz Game

    Science.gov (United States)

    Tsai, Fu-Hsing

    2016-01-01

    This study aims to investigate whether different player-matching mechanisms in educational multi-player online games (MOGs) can affect students' learning performance, enjoyment perception and gaming behaviors. Based on the multi-player quiz game, TRIS-Q, developed by Tsai, Tsai and Lin (2015) using a free player-matching (FPM) mechanism, the same…

  9. Sphingolipids and mitochondrial apoptosis.

    Science.gov (United States)

    Patwardhan, Gauri A; Beverly, Levi J; Siskind, Leah J

    2016-04-01

    The sphingolipid family of lipids modulate several cellular processes, including proliferation, cell cycle regulation, inflammatory signaling pathways, and cell death. Several members of the sphingolipid pathway have opposing functions and thus imbalances in sphingolipid metabolism result in deregulated cellular processes, which cause or contribute to diseases and disorders in humans. A key cellular process regulated by sphingolipids is apoptosis, or programmed cell death. Sphingolipids play an important role in both extrinsic and intrinsic apoptotic pathways depending on the stimuli, cell type and cellular response to the stress. During mitochondrial-mediated apoptosis, multiple pathways converge on mitochondria and induce mitochondrial outer membrane permeabilization (MOMP). MOMP results in the release of intermembrane space proteins such as cytochrome c and Apaf1 into the cytosol where they activate the caspases and DNases that execute cell death. The precise molecular components of the pore(s) responsible for MOMP are unknown, but sphingolipids are thought to play a role. Here, we review evidence for a role of sphingolipids in the induction of mitochondrial-mediated apoptosis with a focus on potential underlying molecular mechanisms by which altered sphingolipid metabolism indirectly or directly induce MOMP. Data available on these mechanisms is reviewed, and the focus and limitations of previous and current studies are discussed to present important unanswered questions and potential future directions.

  10. Psychosocial Factors Involved in Transitions from College to Postcollege Careers for Male NCAA Division-1 Basketball Players

    Science.gov (United States)

    Cummins, Paul; O'Boyle, Ian

    2015-01-01

    This article investigated the key psychosocial factors that impact upon National Collegiate Athletic Association (NCAA) Division-1 male basketball players, as they transition from college to postcollege athletic or nonathletic careers. Participants (N = 9) were current/former NCAA Division-1 basketball players. Four participants were selected…

  11. The NBA’s Maximum Player Salary and the Distribution of Player Rents

    Directory of Open Access Journals (Sweden)

    Kelly M. Hastings

    2015-03-01

    Full Text Available The NBA’s 1999 Collective Bargaining Agreement (CBA included provisions capping individual player pay in addition to team payrolls. This study examines the effect the NBA’s maximum player salary on player rents by comparing player pay from the 1997–1998 and 2003–2004 seasons while controlling for player productivity and other factors related to player pay. The results indicate a large increase in the pay received by teams’ second highest and, to a lesser extent, third highest paid players. We interpret this result as evidence that the adoption of the maximum player salary shifted rents from stars to complementary players. We also show that the 1999 CBA’s rookie contract provisions reduced salaries of early career players.

  12. Invertebrate Iridovirus Modulation of Apoptosis

    Institute of Scientific and Technical Information of China (English)

    Trevor Williams; Nllesh S. Chitnis; Sh(a)n L. Bilimoria

    2009-01-01

    Programmed cell death (apoptosis) is a key host response to virus infection. Viruses that can modulate host apoptotic responses are likely to gain important opportunities for transmission. Here we review recent studies that demonstrate that particles of Invertebrate iridescent virus 6 (IIV-6) (Iridoviridae, genus Iridovirus), or an IIV-6 virion protein extract, are capable of inducing apoptosis in lepidopteran and coleopteran cells, at concentrations 1000-fold lower than that required to shut-off host macromolecular synthesis. Induction of apoptosis depends on endocytosis of one or more heat-sensitive virion component(s). Studies with a JNK inh ibitor(SP600125) indicated that the JNK signaling pathway is significantly involved in apoptosis in IIV-6 infections of Choristoneurafumiferana ceils. The genome of IIV-6 codes for an inhibitor of apoptosis iap gene (193R) that encodes a protein of 208 aa with 15% identity and 28% similarity in its amino acid sequence to IAP-3 from Cydia pomonella ganulovirus (CpGV). Transcription of IIV-6 iap did not require prior DNA or protein synthesis, indicating that it is an immediate-early class gene. Transient expression and gene knockdown studies have confirmed the functional nature of the IIV-6 iap gene. We present a tentative model for IIV-6 induction and inhibition of apoptosis in insect cells and discuss the potential applications of these findings in insect pest control.

  13. Molecular signal transduction in vascular cell apoptosis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical forces, reactive oxygen and nitrogen species, cytokines, growth factors, oxidized lipoproteins, etc., may influence apoptosis of vascular cells. The Fas/Fas ligand/caspase death-signaling pathway, Bcl-2 protein family/mitochondria, the tumor suppressive gene p53, and the proto-oncogene c-myc may be activated in atherosclerotic lesions, and mediates vascular apoptosis during the development of atherosclerosis. Abnormal expression and dysfunction of these apoptosis-regulating genes may attenuate or accelerate vascular cell apoptosis and affect the integrity and stability of atherosclerotic plaques. Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes.

  14. IgE - the main player of food allergy

    DEFF Research Database (Denmark)

    Broekman, Henrike C H; Eiwegger, Thomas; Upton, Julia

    2017-01-01

    Food allergy is a growing problem worldwide, presently affecting 2-4% of adults and 5-8% of young children. IgE is a key player in food allergy. Consequently huge efforts have been made to develop tests to detect either the presence of IgE molecules, their allergen binding sites or their function......Food allergy is a growing problem worldwide, presently affecting 2-4% of adults and 5-8% of young children. IgE is a key player in food allergy. Consequently huge efforts have been made to develop tests to detect either the presence of IgE molecules, their allergen binding sites...... or their functionality, in order to provide information regarding the patient's food allergy. The ultimate goal is to develop tools that are capable of discriminating between asymptomatic sensitization and a clinically relevant food allergy, and between different allergic phenotypes in an accurate and trustworthy manner...

  15. Adapting playware to multiple players

    DEFF Research Database (Denmark)

    Þorsteinsson, Arnar Tumi; Lund, Henrik Hautop; Mastorakis, Nikos

    2011-01-01

    With the creation of playware as intelligent hardware and software that creates play, it is possible to adapt the play tool to the individual user, and even to multiple users playing at the same time with the play tool. In this paper, we show how it is possible to implement adaptivity in modular...... to such differences, and argues that adaptivity is needed to make games fit to the individual users in both single-player games and multi-player games. As a case study, we implemented such adaptivity on modular interactive tiles for the single-user game ColorTimer, and for the multiple-user games PingPong, in which...

  16. Psychological games of entangled players

    CERN Document Server

    Zak, Michail

    2012-01-01

    The paper introduces a new approach to theory of differential games in which entangled players try to predict and influence actions of their adversaries. The entanglement is generated be a joint probability density known by the players. Incase of complex density, its imaginary part represents a measure of uncertainty of the density distribution. The novelty of the approach is in non-Newtonian mathematical formalism thatis based upon a behavioral model of Livings. The model is quantum-inspired: it represented by a modified Madelung equation which the quantum potential is replaced by different, specially chosen "computational" potential. It consists of motor dynamics simulating actual behavior of the object, and mental dynamics representing evolution of the corresponding knowledge-based and incorporating this knowledge in the for m of information flows into the motor dynamics. Due to feedback from mental dynamics, motor dynamics attains quantum-like properties: its trajectory splits into a family of different t...

  17. Two-Player Graph Pebbling

    Science.gov (United States)

    Prudente, Matthew James

    Given a graph G with pebbles on the vertices, we define a pebbling move as removing two pebbles from a vertex u, placing one pebble on a neighbor v, and discarding the other pebble, like a toll. The pebbling number pi( G) is the least number of pebbles needed so that every arrangement of pi(G) pebbles can place a pebble on any vertex through a sequence of pebbling moves. We introduce a new variation on graph pebbling called two-player pebbling. In this, players called the mover and the defender alternate moves, with the stipulation that the defender cannot reverse the previous move. The mover wins only if they can place a pebble on a specified vertex and the defender wins if the mover cannot. We define η(G), analogously, as the minimum number of pebbles such that given every configuration of the η( G) pebbles and every specified vertex r, the mover has a winning strategy. First, we will investigate upper bounds for η( G) on various classes of graphs and find a certain structure for which the defender has a winning strategy, no matter how many pebbles are in a configuration. Then, we characterize winning configurations for both players on a special class of diameter 2 graphs. Finally, we show winning configurations for the mover on paths using a recursive argument.

  18. Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts.

    Directory of Open Access Journals (Sweden)

    Shuli Li

    Full Text Available Neural crest-derived (FOb and mesoderm-derived (POb calvarial osteoblasts are characterized by distinct differences in their osteogenic potential. We have previously demonstrated that enhanced activation of endogenous FGF and Wnt signaling confers greater osteogenic potential to FOb. Apoptosis, a key player in bone formation, is the main focus of this study. In the current work, we have investigated the apoptotic activity of FOb and POb cells during differentiation. We found that lower apoptosis, as measured by caspase-3 activity is a major feature of neural crest-derived osteoblast which also have higher osteogenic capacity. Further investigation indicated TGF-β signaling as main positive regulator of apoptosis in these two populations of calvarial osteoblasts, while BMP and canonical Wnt signaling negatively regulate the process. By either inducing or inhibiting these signaling pathways we could modulate apoptotic events and improve the osteogenic potential of POb. Taken together, our findings demonstrate that integration of multiple signaling pathways contribute to imparting greater osteogenic potential to FOb by decreasing apoptosis.

  19. Dynamical Stability and Predictability of Football Players: The Study of One Match

    Directory of Open Access Journals (Sweden)

    Micael S. Couceiro

    2014-01-01

    Full Text Available The game of football demands new computational approaches to measure individual and collective performance. Understanding the phenomena involved in the game may foster the identification of strengths and weaknesses, not only of each player, but also of the whole team. The development of assertive quantitative methodologies constitutes a key element in sports training. In football, the predictability and stability inherent in the motion of a given player may be seen as one of the most important concepts to fully characterise the variability of the whole team. This paper characterises the predictability and stability levels of players during an official football match. A Fractional Calculus (FC approach to define a player’s trajectory. By applying FC, one can benefit from newly considered modeling perspectives, such as the fractional coefficient, to estimate a player’s predictability and stability. This paper also formulates the concept of attraction domain, related to the tactical region of each player, inspired by stability theory principles. To compare the variability inherent in the player’s process variables (e.g., distance covered and to assess his predictability and stability, entropy measures are considered. Experimental results suggest that the most predictable player is the goalkeeper while, conversely, the most unpredictable players are the midfielders. We also conclude that, despite his predictability, the goalkeeper is the most unstable player, while lateral defenders are the most stable during the match.

  20. Modulation of PKC signaling and induction of apoptosis through suppression of reactive oxygen species and tumor necrosis factor receptor 1 (TNFR1): key role of quercetin in cancer prevention.

    Science.gov (United States)

    Maurya, Akhilendra Kumar; Vinayak, Manjula

    2015-11-01

    Cancer cells are characterized by increased production of reactive oxygen species (ROS) and an altered redox environment as compared to normal cells. Continuous accumulation of ROS triggers oxidative stress leading to hyper-activation of signaling pathways that promote cell proliferation, survival, and metabolic adaptation to the tumor microenvironment. Therefore, antioxidants are proposed to contribute to cancer prevention. Protein kinase C (PKC) is a crucial regulator of diverse cellular processes and contributes to cancer progression. The activation of PKC is partially dependent on ROS signaling. In the present study, cancer preventive activity of natural flavonoid quercetin is analyzed in ascite cells of Dalton's lymphoma-bearing mice. The total ROS level and activity of PKC were downregulated after quercetin treatment in lymphoma-bearing mice. Quercetin modulates the expression of almost all isozymes of classical, novel, and atypical PKC as well as downregulates the level and expression of PKCα. Further, quercetin improves apoptotic potential, as observed by the levels of caspase 3, caspase 9, PARP, PKCδ, and nuclear condensation. Additionally, quercetin reduces cell survival and promotes death receptor-mediated apoptosis via differential localization of the TNFR1 level in ascite cells. The overall result suggests the cancer preventive activity of quercetin via the induction of apoptosis and modulates PKC signaling with the reduction of oxidative stress in ascite cells of lymphoma-bearing mice.

  1. Serious eye injury in badminton players.

    Science.gov (United States)

    Kelly, S P

    1987-10-01

    Serious eye injury can occur in badminton players and may become more frequent. The causes and nature of such injuries in this sport in six patients are discussed. All were playing competitive doubles matches. Penetrating eye injury due to a shattered glass spectacle lens occurred. Players should be advised not to wear spectacles with glass lenses. Ocular protection in this sport is desirable, and the forward player should hold the racket in front of the face.

  2. Player-character dynamics in multi-player Role Playing Games

    DEFF Research Database (Denmark)

    Tychsen, Anders; McIlwain, Doris; Brolund, Thea

    2007-01-01

    This paper presents the results of a comprehensive empirical study of the impact of integrating complex game characters in multi-player Role Playing Games across tabletop and digital formats. Players were provided with characters that had detailed background history, personality and goals. Player...... and player engagement with their character and no correlation between enjoyment and similarity between player and character personality. © 2007 Authors & Digital Games Research Association (DiGRA)....... and character personality were assessed using the Extended Personal Attributes Questionnaire (EPAQ) and further questionnaires administered to measure player enjoyment and the player-character relationship. Results include a high level of player enjoyment across all formats, a high correlation between enjoyment...

  3. An investigation of player to player character identification via personal pronouns

    DEFF Research Database (Denmark)

    Hichens, Michael; Drachen, Anders; Richards, Deborah

    2012-01-01

    The player character is an important feature of many games, where it is through the character that the player interacts with game world. There has been considerable interest in the relationship between the player and the player character. Much of this work has examined the identification of players...... in playing video games, did have a statistically significant affect, indicating that different levels of identification are more dependent on the player than on the game. This indicates that players are not a homogeneous group with respect to player character identification and is an important consideration...... with their characters, generally taking either a textual analysis approach, or has been empirical work that has explicitly identified the idea of identification through survey instruments, etc. The work presented here takes a different empirical approach, focusing on the use of various pronoun forms (first, second...

  4. Chess players' fame versus their merit

    CERN Document Server

    Simkin, M V

    2015-01-01

    We investigate a pool of international chess title holders born between 1901 and 1943. Using Elo ratings we compute for every player his expected score in a game with a randomly selected player from the pool. We use this figure as player's merit. We measure players' fame as the number of Google hits. The correlation between fame and merit is 0.38. At the same time the correlation between the logarithm of fame and merit is 0.61. This suggests that fame grows exponentially with merit.

  5. The Prevalence of Injuries in Professional Turkish Soccer Players

    Science.gov (United States)

    Yamaner, Faruk; Gumusdag, Hayrettin; Kartal, Alparslan; Gumus, M.; Gullu, A.; Imamoglu, O.

    2011-01-01

    Study aim: To assess the prevalence and anatomical sites of injuries in professional soccer players in one game season. Material and methods: A cohort of 510 professional male soccer players consisting of 48 goalkeepers, 194 defence players, 189 mid-field players and 79 forward players of the 1st and 2nd Turkish Professional Soccer Leagues in…

  6. Contributions to Using IT in Education: An Educational Video Player

    Directory of Open Access Journals (Sweden)

    Ciprian CUCU

    2010-01-01

    Full Text Available Following the trends of IT use in education we propose four main principles of educational application development: anytime-anywhere access (including access for mobile devices; user-generated content; assigning users an active role inside the platform; creating a correlation between natural activities and educational activities – adding fun into the equation. With these principles in mind we developed a small Educational Player – a movie player that connects to a database to show information relevant to the events in the movie, more specific to the exact key-frame (in the movie time-line at the moment of the request. Though the application is still in a conceptual form, its possibilities make us confident in its future success either as an informal way of learning, or by using it in a formal educational context either as an e-learning tool, either as interactivity tool in a traditional classroom setting.

  7. The Distribution of Benefits for Players in Agricultural Industrial Chain

    Institute of Scientific and Technical Information of China (English)

    Wanming; LI; Huibo; SUN

    2015-01-01

    Players of the agricultural industrial chain pursue their own profit maximization,which can lead to conflicts of interest and affect the stability of the industrial chain. Therefore,fair and reasonable profit allocation mechanism is the key to guaranteeing the development and strengthening the strategic alliance relationship between participate members. Shapley model is an effective method to solve the profit distribution in cooperative relations. But it does not consider the three factors: risks faced by players during the operation of the agricultural industrial chain,technology innovation ability,and the degree of participating in the cooperation. So,correction factors are introduced to modify the Shapley value model,in order to make the distribution of benefits more equitable and reasonable,and effectively guide practice.

  8. β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway

    Directory of Open Access Journals (Sweden)

    Zhang Dong

    2011-11-01

    Full Text Available Abstract Background Smoking and stress, pancreatic cancer (PanCa risk factors, stimulate nitrosamine 4-(methylnitrosamino-1-(3-pyridyl-1-butanone (NNK and catecholamines production respectively. NNK and catecholamine bind the β-adrenoceptors and induce PanCa cell proliferation; and we have previously suggested that β-adrenergic antagonists may suppress proliferation and invasion and stimulate apoptosis in PanCa. To clarify the mechanism of apoptosis induced by β2-adrenergic antagonist, we hypothesize that blockage of the β2-adrenoceptor could induce G1/S phase arrest and apoptosis and Ras may be a key player in PanCa cells. Results The β1 and β2-adrenoceptor proteins were detected on the cell surface of PanCa cells from pancreatic carcinoma specimen samples by immunohistochemistry. The β2-adrenergic antagonist ICI118,551 significantly induced G1/S phase arrest and apoptosis compared with the β1-adrenergic antagonist metoprolol, which was determined by the flow cytometry assay. β2-adrenergic antagonist therapy significantly suppressed the expression of extracellular signal-regulated kinase, Akt, Bcl-2, cyclin D1, and cyclin E and induced the activation of caspase-3, caspase-9 and Bax by Western blotting. Additionally, the β2-adrenergic antagonist reduced the activation of NFκB in vitro cultured PanCa cells. Conclusions The blockage of β2-adrenoceptor markedly induced PanCa cells to arrest at G1/S phase and consequently resulted in cell death, which is possibly due to that the blockage of β2-adrenoceptor inhibited NFκB, extracellular signal-regulated kinase, and Akt pathways. Therefore, their upstream molecule Ras may be a key factor in the β2-adrenoceptor antagonist induced G1/S phase arrest and apoptosis in PanCa cells. The new pathway discovered in this study may provide an effective therapeutic strategy for PanCa.

  9. Activation of apoptosis in NAF-1-deficient human epithelial breast cancer cells

    Science.gov (United States)

    Holt, Sarah H.; Darash-Yahana, Merav; Sohn, Yang Sung; Song, Luhua; Karmi, Ola; Tamir, Sagi; Michaeli, Dorit; Luo, Yuting; Paddock, Mark L.; Jennings, Patricia A.; Onuchic, José N.; Azad, Rajeev K.; Pikarsky, Eli; Cabantchik, Ioav Z.; Nechushtai, Rachel; Mittler, Ron

    2016-01-01

    ABSTRACT Maintaining iron (Fe) ion and reactive oxygen species homeostasis is essential for cellular function, mitochondrial integrity and the regulation of cell death pathways, and is recognized as a key process underlying the molecular basis of aging and various diseases, such as diabetes, neurodegenerative diseases and cancer. Nutrient-deprivation autophagy factor 1 (NAF-1; also known as CISD2) belongs to a newly discovered class of Fe-sulfur proteins that are localized to the outer mitochondrial membrane and the endoplasmic reticulum. It has been implicated in regulating homeostasis of Fe ions, as well as the activation of autophagy through interaction with BCL-2. Here we show that small hairpin (sh)RNA-mediated suppression of NAF-1 results in the activation of apoptosis in epithelial breast cancer cells and xenograft tumors. Suppression of NAF-1 resulted in increased uptake of Fe ions into cells, a metabolic shift that rendered cells more susceptible to a glycolysis inhibitor, and the activation of cellular stress pathways that are associated with HIF1α. Our studies suggest that NAF-1 is a major player in the metabolic regulation of breast cancer cells through its effects on cellular Fe ion distribution, mitochondrial metabolism and the induction of apoptosis. PMID:26621032

  10. Apoptosis in Primary Hyperparathyroidism.

    Science.gov (United States)

    Segiet, Oliwia Anna; Mielańczyk, Łukasz; Piecuch, Adam; Michalski, Marek; Tyczyński, Szczepan; Brzozowa-Zasada, Marlena; Deska, Mariusz; Wojnicz, Romuald

    2017-03-31

    Primary hyperparathyroidism (PHPT) is defined by inappropriate elevation of parathormone, caused by parathyroid hyperplasia, also known as multi-gland disease (MGD), parathyroid adenoma (PA), or parathyroid carcinoma (PC). Although several studies have already been conducted, there is a lack of a definite diagnostic marker, which could unambiguously distinguish MGD from PA or PC. The accurate and prompt diagnosis has the key meaning for effective treatment and follow-up. This review paper presents the role of apoptosis in PHPT. The comparison of the expression of Fas, TRAIL, BCL-2 family members, p53 in MGD, PA, and PC, among others, was described. The expression of described factors varies among proliferative lesions of parathyroid gland; therefore, these could serve as additional markers to assist in the diagnosis.

  11. Cooperation: New Players in Africa

    Directory of Open Access Journals (Sweden)

    Philippe Hugon

    2010-03-01

    Full Text Available In the context of globalisation and the current global financial crisis, new players are emerging in cooperation in Africa. These partners loosen financial constraints and conditionalities, increase the room for manoeuvre and stimulate commodity markets. On the other hand, they also increase the risks of renewed indebtedness and potentially weaken the coordination of aid policies. Do these partnerships call the new cooperation practices of OECD countries into question? Do they justify the return to a realpolitik or are they repeating the earlier mistakes of industrial powers? Can these mistakes be corrected? The question also arises as to whether the global crisis, which has a profound effect on Africa, will lead to a withdrawal or to a passing of the baton on to new, emerging powers. This article highlights the new geopolitical issues concerning Africa in a multipolar world, then discusses the new players involved in cooperation in Africa, before going on to explore the horizons that are opening up for cooperation in Africa, in particular with regard to the global crisis.

  12. Who Are the Players in Canadian Curriculum?

    Science.gov (United States)

    Milburn, Geoffrey

    1987-01-01

    Labels range of persons advocating different theoretical positions of Canadian curriculum as "players." Describes players as "managers,""predictors,""transformers,""sleuths,""analysts." Values varied viewpoints for attention to language regarding curriculum, critical review of ideas/concepts, examination of current policies, awareness of history…

  13. QuizUp Single Player Web

    OpenAIRE

    Gunnar Marteinsson 1983; Kristinn Júlíusson 1993; Sonja Jónsdóttir 1992; Steinar Þór Árnason 1993

    2016-01-01

    In this report we discuss the B.Sc. project named QuizUp Single Player Web. The project was developed at Reykjavik University in the spring of 2016 in collaboration with Plain Vanilla Games, the makers of the world famous QuizUp app. We developed a Single Player Web application based on the original multiplayer game.

  14. The potential risk of personal stereo players

    DEFF Research Database (Denmark)

    Hammershøi, Dorte; Ordoñez, Rodrigo Pizarro; Reuter, Karen

    2010-01-01

    The technological development within personal stereo systems, such as MP3 players, e. g. iPods, has changed music listening habits from home entertainment to everyday and everywhere use. The technology has developed considerably, since the introduction of cassette players and CD walkmen. High...

  15. The potential risk of personal stereo players

    DEFF Research Database (Denmark)

    Hammershøi, Dorte; Ordoñez, Rodrigo Pizarro; Reuter, Karen

    2010-01-01

    The technological development within personal stereo systems,such as MP3 players, e. g. iPods, has changed music listening habits from home entertainment to everyday and everywhere use. The technology has developed considerably, since the introduction of cassette players and CD walkmen. High...

  16. Inferring Player Experiences Using Facial Expressions Analysis

    NARCIS (Netherlands)

    Tan, C.T.; Bakkes, S.; Pisan, Y.; Blackmore, K.; Nesbitt, K.; Smith, S.P.

    2014-01-01

    Understanding player experiences is central to game design. Video captures of players is a common practice for obtaining rich reviewable data for analysing these experiences. However, not enough has been done in investigating ways of preprocessing the video for a more efficient analysis process. Thi

  17. Injuries in racket sports among Slovenian players.

    Science.gov (United States)

    Kondric, Miran; Matković, Branka R; Furjan-Mandić, Gordana; Hadzić, Vedran; Dervisević, Edvin

    2011-06-01

    On the sample of 83 top Slovenian athletes we have studied the frequency of injuries among table tennis, tennis and badminton players, types of injuries and severity of injuries--the latter based on data of players absences from training and/or competition processes. The most liable parts to injuries are shoulder girdle (17.27%), spine (16.55%) and ankle (15.83%), while foot (10.07%) and wrist (12.23%) are slightly less liable to injuries. The most frequent injuries in racket sports pertain to muscle tissues. According to this data, the majority of injuries occur halfway through a training session or a competition event, mostly during a competition season. The injuries primarily pertain to muscle tissues; these are followed by joint and tendon injuries. There are no differences between male and female players. Compared to other racket sports players, table tennis players suffer from fewer injuries.

  18. Executive functioning in highly talented soccer players.

    Science.gov (United States)

    Verburgh, Lot; Scherder, Erik J A; van Lange, Paul A M; Oosterlaan, Jaap

    2014-01-01

    Executive functions might be important for successful performance in sports, particularly in team sports requiring quick anticipation and adaptation to continuously changing situations in the field. The executive functions motor inhibition, attention and visuospatial working memory were examined in highly talented soccer players. Eighty-four highly talented youth soccer players (mean age 11.9), and forty-two age-matched amateur soccer players (mean age 11.8) in the age range 8 to 16 years performed a Stop Signal task (motor inhibition), the Attention Network Test (alerting, orienting, and executive attention) and a visuospatial working memory task. The highly talented soccer players followed the talent development program of the youth academy of a professional soccer club and played at the highest national soccer competition for their age. The amateur soccer players played at a regular soccer club in the same geographical region as the highly talented soccer players and play in a regular regional soccer competition. Group differences were tested using analyses of variance. The highly talented group showed superior motor inhibition as measured by stop signal reaction time (SSRT) on the Stop Signal task and a larger alerting effect on the Attention Network Test, indicating an enhanced ability to attain and maintain an alert state. No group differences were found for orienting and executive attention and visuospatial working memory. A logistic regression model with group (highly talented or amateur) as dependent variable and executive function measures that significantly distinguished between groups as predictors showed that these measures differentiated highly talented soccer players from amateur soccer players with 89% accuracy. Highly talented youth soccer players outperform youth amateur players on suppressing ongoing motor responses and on the ability to attain and maintain an alert state; both may be essential for success in soccer.

  19. Finite stage asymmetric repeated games: Both players' viewpoints

    KAUST Repository

    Li, Lichun

    2017-01-05

    In asymmetric zero-sum games, one player has superior information about the game over the other. It is known that the informed players (maximizer) face the tradeoff of exploiting its superior information at the cost of revealing its superior information, but the basic point of the uninformed player (minimizer)\\'s decision making remains unknown. This paper studies the finite stage asymmetric repeated games from both players\\' viewpoints, and derives that not only security strategies but also the opponents\\' corresponding best responses depends only on the informed player\\'s history action sequences. Moreover, efficient LP formulations to compute both player\\'s security strategies are provided.

  20. Unexpected cellular players in Rett syndrome pathology.

    Science.gov (United States)

    Cronk, James C; Derecki, Noel C; Litvak, Vladimir; Kipnis, Jonathan

    2016-08-01

    Rett syndrome is a devastating neurodevelopmental disorder, primarily caused by mutations of methyl CpG-binding protein 2 (MeCP2). Although the genetic cause of disease was identified over a decade ago, a significant gap still remains in both our clinical and scientific understanding of its pathogenesis. Neurons are known to be primary players in pathology, with their dysfunction being the key in Rett syndrome. While studies in mice have demonstrated a clear causative - and potential therapeutic - role for neurons in Rett syndrome, recent work has suggested that other tissues also contribute significantly to progression of the disease. Indeed, Rett syndrome is known to present with several common peripheral pathologies, such as osteopenia, scoliosis, gastrointestinal problems including nutritional defects, and general growth deficit. Mouse models assessing the potential role of non-neuronal cell types have confirmed both roles in disease and potential therapeutic targets. A new picture is emerging in which neurons both initiate and drive pathology, while dysfunction of other cell types and peripheral tissues exacerbate disease, possibly amplifying further neurologic problems, and ultimately result in a positive feedback loop of progressively worsening symptoms. Here, we review what is known about neuronal and non-neuronal cell types, and discuss how this new, integrative understanding of the disease may allow for additional clinical and scientific pathways for treating and understanding Rett syndrome.

  1. Anthropometric profile and body composition of Irish adolescent rugby union players aged 16-18.

    Science.gov (United States)

    Delahunt, Eamonn; Byrne, Risteard B; Doolin, Rachel K; McInerney, Rory G; Ruddock, Ciaran T J; Green, Brian S

    2013-12-01

    The literature suggests that one of the key determinants of success at rugby union international competitions is the anthropometric profile of players. The Irish Rugby Football Union (IRFU) long-term player development (LTPD) model is a framework designed to guide the development of the tactical, physical, and psychological domains of sporting participation. In Ireland, the Train-to-Train stage of the IRFU model is a critical stage, whereby the next developmental progression would include the transition of players into professional academies. To date, no previously published studies have examined the anthropometric profile of Irish Schools' rugby union players at the Train-to-Train stage of the IRFU model. The anthropometric profile of 136 male adolescent rugby union players at the Train-to-Train stage of the IRFU model was assessed using total-body dual-energy x-ray absorptiometry. Significant differences in height, body mass, body fat percentage, fat mass, lean mass, and fat-free mass were observed between players assigned to the forward and back units, and for specific position categorizations within each unit. Direct logistic regression revealed that body mass was a statistically significant (p anthropometric profiles. Furthermore, anthropometric differentiation also exists within specific position categorizations within each of these playing units. Thus, anthropometric profiling should be carried out on a systematic and periodic basis, because this will allow for the evaluation of the effectiveness of the implementation strategies of the IRFU model on a national basis.

  2. Examining Player Anger in World of Warcraft

    Science.gov (United States)

    Barnett, Jane; Coulson, Mark; Foreman, Nigel

    This questionnaire study of the sources of anger in World of Warcraft applies classical quantitative measurement scale construction to a new problem, generating a host of questionnaire items that could find use in future studies, and identifying four major categories of events that cause negative effect among players. First, 33 players provided examples of in-game scenarios that had made them angry, and their responses were culled to create a 93-item battery rated by hundreds of player respondents in terms of anger intensity and anger frequency. An iterative process of factor analysis and scale reliability assessment led to a 28-item instrument measuring four anger-provoking factors: Raids/Instances, Griefers, Perceived Time Wasting, and Anti-social Players. These anger-causing scenarios were then illustrated by concrete examples from player and researcher experiences in World of Warcraft. One striking finding is that players become angry at other players' negative behavior, regardless of whether that behavior was intended to harm.

  3. Physiological characteristics of international female soccer players.

    Science.gov (United States)

    Manson, Sarah A; Brughelli, Matt; Harris, Nigel K

    2014-02-01

    The purpose of this study was to investigate the physiological characteristics of Fédération Internationale de Football Association (FIFA) eligible international female soccer players aged 14-36 years and to determine if measures were significantly different for players selected (i.e., starters) to the starting line up for an FIFA tournament as compared with those not selected (i.e., nonstarters). Fifty-one (N = 18 Under 17; N = 18 Under 20; N = 15 Senior) international female soccer players participated in this study. The subjects underwent measurements of anthropometry (height and body mass), lower body strength (isokinetic testing), sprint kinetics and kinematics (nonmotorized treadmill), leg power (unilateral jumping), and maximal aerobic velocity (30:15 intermittent fitness test) during the final preparatory stage for an FIFA event. Outcomes of the age group data indicate that differences in physiological capacities are evident for the Under 17 players as compared with those for the Under 20 and Senior capped international players, suggesting a plateau in the acquisition of physical qualities as players mature. Starters tended to be faster (effect size [ES] = 0.55-1.0, p < 0.05) and have a higher maximal aerobic velocity (ES = 0.78-2.45, p < 0.05), along with greater eccentric leg strength (ES = 0.33-1.67, p < 0.05). Significant differences were detected between starters and nonstarters for isokinetic leg strength (ES = 0.54-1.24, p < 0.05) and maximal aerobic velocity (ES = 0.87, p < 0.05) for Under 17 players, where maximal aerobic velocity was the primary difference between starters and nonstarters (ES = 0.83-2.45, p < 0.05) for the Under 20 and Senior players. Coaches should emphasize the development of speed, maximal aerobic velocity, and leg strength in developing female soccer players.

  4. Stochastic modeling of p53-regulated apoptosis upon radiation damage

    CERN Document Server

    Bhatt, Divesh; Bahar, Ivet

    2011-01-01

    We develop and study the evolution of a model of radiation induced apoptosis in cells using stochastic simulations, and identified key protein targets for effective mitigation of radiation damage. We identified several key proteins associated with cellular apoptosis using an extensive literature survey. In particular, we focus on the p53 transcription dependent and p53 transcription independent pathways for mitochondrial apoptosis. Our model reproduces known p53 oscillations following radiation damage. The key, experimentally testable hypotheses that we generate are - inhibition of PUMA is an effective strategy for mitigation of radiation damage if the treatment is administered immediately, at later stages following radiation damage, inhibition of tBid is more effective.

  5. La mala educación of tumor-associated macrophages: Diverse pathways and new players.

    Science.gov (United States)

    Mantovani, Alberto

    2010-02-17

    Inflammation is a key component of the tumor microenvironment. Two reports published in this issue of Cancer Cell, Andreu et al. and Erez et al., shed new light on pathways and players involved in the orchestration of cancer-related inflammation.

  6. A Wiki-based Key to Garden and Village Birds

    OpenAIRE

    Trilar, Tomi

    2010-01-01

    A Wiki-based Key to Garden and Village Birds is available in two versions: a dichotomous, hyperlinked and printable version, and as step-bystep identification version. It is supported by jKey Player in English, Slovenian, Spanish, Romanian and German.

  7. [Depression and treatment. Apoptosis, neuroplasticity and antidepressants].

    Science.gov (United States)

    Arantes-Gonçalves, Filipe; Coelho, Rui

    2006-01-01

    Depression's neurobiology begins to be better understood. The last decade data considers neuroplasticity and stress as implicated factors on the pathophisiology of depression. Because antidepressants have a lag-time on their action it is possible that inhibition of neurotransmitters recaptation is not sufficient to explain long term changes. For that purpose, neurogenesis increase, nervous fibers sprouting, new synapses and stabilization of the old ones can be responsible for those changes. AMPc-MAPcinases-CREB-BDNF cellular cascade can play a significant role in the mechanisms of dendritic restructuration, hippocampal neurogenesis increase and nervous cells survival. The aim of this article is to discuss if apoptosis could play a key role as an ethiopathogenic factor on the patogenesis of depression. It was done a medline search for references with apoptosis, stress, neuroplasticity, depression and antidepressants key-words. It were found 101 original or review references about these subjects. Stress plays a key role in the etiopathogeny of depression. Its deletery effects on apoptosis and neuroplasticity can be changed by antidepressants. Neurogenesis' increase is necessary for their action. This increase is reached with chronic antidepressant treatment and not with other psychotropic drugs which means some pharmacological specificity of antidepressants. AMPc, CREB, BDNF and Bcl-2 can be considered as target genes in antidepressant synthesis. At the level of this neurotrophic factors apoptosis might be included in the neuroplastic model of depression and play a prominent role in etiopathogeny of depression. To confirm that, we need more research on the field to know which are the mechanisms that trigger apoptosis and its biological significance. In relation to the last one, we can say that is possible to be physiological apoptosis in deteriorated neurons death which cannot make strong connections and pathological apoptosis because of stress via, namely, HPA axis.

  8. Menstrual cycle disorders in female volleyball players.

    Science.gov (United States)

    Wodarska, M; Witkoś, J; Drosdzol-Cop, A; Dąbrowska, J; Dąbrowska-Galas, M; Hartman, M; Plinta, R; Skrzypulec-Plinta, V

    2013-07-01

    The aim of this study was to examine the relation between increased physical activity and menstrual disorders in adolescent female volleyball players. The study was conducted on 210 Polish female volleyball players, aged 13-17 years, the authorship questionnaire was used. The results of the study showed that irregular menstruation occurred in 19% of girls, spotting between menstrual periods in 27% and heavy menstruation was reported in 33% of girls. Out of all volleyball female players participating in the study, 94 girls (45%) declared absence of menstrual periods after regular cycles. Statistical analysis showed that the more training hours per week, the bigger probability of the occurrence of irregular menstruation. It was concluded that the number of hours of volleyball training per week affects regularity of menstrual cycles in female volleyball players. The absence of menstruation might be caused by the duration of training per week or years of training.

  9. Video Player Keyboard Shortcuts: MedlinePlus

    Science.gov (United States)

    ... page: https://medlineplus.gov/hotkeys.html Video Player Keyboard Shortcuts To use the sharing features on this ... enable JavaScript. MedlinePlus offers a set of accessible keyboard shortcuts for our latest Health videos on the ...

  10. The Cheerleader and the Football Player.

    Science.gov (United States)

    Patil, Malati

    2001-01-01

    Describes an activity in physics using a narrative about a bet between a cheerleader who claims she can lift a 300-pound football player off the ground. Includes questions, teaching notes, and solutions. (MM)

  11. Anthropometry of World-Class Elite Handball Players According to the Playing Position: Reports From Men's Handball World Championship 2013.

    Science.gov (United States)

    Ghobadi, Hamid; Rajabi, Hamid; Farzad, Babak; Bayati, Mahdi; Jeffreys, Ian

    2013-12-18

    Identifying the anthropometric measures of successful and less successful handball players may be helpful in developing a talent identification and development model, allowing for the determination of key physical capacities required for elite performance. The purpose of the study was to describe the anthropometric characteristics, including age, standing stature, body mass and body mass index (BMI) in handball players who participated in the 2013 Men's Handball World Championships. Secondly, the objective was to identify the possible differences in these parameters in terms of individual playing positions (goalkeeper, back, center back, wing, line player). Rosters with handball player's age, standing stature, and body mass were obtained from the International Handball Federation website. The research material included 409 handball players (24 teams). National teams were organized by their ranks and sub-grouped using their continents and playing positions. The results of the analyses of variance demonstrated significant differences in age (F=2.30; p=0.044; Partial ŋ2=0.028), standing stature (F=14.02; p=0.0001; Partial ŋ2=0.148), and body mass (F=5.88; p=0.0001; Partial ŋ2=0.068) among the groups (G1-G6). Players in G1 had the highest standing stature and body mass, while players in G6 had the lowest age and body mass values. The backs and line players were the tallest. In addition, the measurement of body mass showed that the line players had the highest body mass and BMI values. In conclusion, this study presented anthropometric data that differentiated levels of success in male handball teams playing in the 2013 world championships. This information should serve as a reference for the average standing stature, body mass, and BMI of handball players for particular positions at the professional level.

  12. High School Football Players Use Their Helmets to Tackle Other Players Despite Knowing the Risks

    Science.gov (United States)

    Kuriyama, Andrew M; Nakatsuka, Austin S

    2017-01-01

    There is greater attention to head-related injuries and concussions in American football. The helmet's structural safety and the way that football players use their helmets are important in preventing head injuries. Current strategies include penalizing players for high-risk behavior such as leading with their helmet or hitting an opposing player above the shoulder. Passive strategies include helmet modification to better protect the head of the players or to change the playing style of the players. Hawai‘i high school varsity football players were surveyed to determine how they use their helmets and how a new helmet design would affect their style of play. One hundred seventy-seven surveys were completed; 79% said that they used their helmet to hit an opposing player during a tackle and 46% said they made this contact intentionally. When asked about modifying helmets with a soft material on the outside, 48% said they thought putting a soft cover over a regular helmet would protect their head better. However, many participants said that putting a soft cover over their regular helmet was a bad idea for various reasons. Most young football players use their helmets to block or tackle despite being taught they would be penalized or potentially injured if they did so. By gaining a better understanding of why and how players use their helmets and how they would respond to new helmet designs, steps can be taken to reduce head injuries for all levels of play.

  13. RETIRED MATCHES AMONG MALE PROFESSIONAL TENNIS PLAYERS

    Directory of Open Access Journals (Sweden)

    Kristijan Breznik

    2012-06-01

    Full Text Available The aim of this study was to explore the effect of characteristics of various games and players on the proportion of retired tennis matches in the Open Era of tennis. The data included over 420,000 matches played among 17,553 tennis players in the period from 1968 to the end of 2010. The influence of the surface type was clearly confirmed, with the proportion of retired matches being higher on hard and clay courts compared to grass and carpet surfaces. Similarly, more retired matches were observed in outdoor venues than in indoor ones. The impact of other variables, tournament types, rounds at which the game was played and both players' ranks, is more ambiguous. Our interpretation of the obtained results is presented in the paper. Network analytic methods were applied to extract players with the most retired matches in their careers. Eventually, we defined a group of top tennis players and gave a more precise insight into retired matches in that group. Correspondence analysis was used to visually display the two-mode network of top players and the proportion of retired matches by surface type

  14. Does the Quantum Player Always Win the Classical One?

    Institute of Scientific and Technical Information of China (English)

    ZHAO Hai-Jun; FANG Xi-Ming

    2004-01-01

    @@ We study quantum games in which the players have different strategic spaces. We find that the player who can use a quantum strategic space does not always possess more payoffs than the player who is restricted to apply only classical strategies. We find the condition of the classical player getting more payoffs than the quantum player. We also find that the game exhibits intriguing structures.

  15. Vapor of volatile oils from Litsea cubeba seed induces apoptosis and causes cell cycle arrest in lung cancer cells.

    Directory of Open Access Journals (Sweden)

    Soma Seal

    Full Text Available Non-small cell lung carcinoma (NSCLC is a major killer in cancer related human death. Its therapeutic intervention requires superior efficient molecule(s as it often becomes resistant to present chemotherapy options. Here we report that vapor of volatile oil compounds obtained from Litsea cubeba seeds killed human NSCLC cells, A549, through the induction of apoptosis and cell cycle arrest. Vapor generated from the combined oils (VCO deactivated Akt, a key player in cancer cell survival and proliferation. Interestingly VCO dephosphorylated Akt at both Ser(473 and Thr(308; through the suppression of mTOR and pPDK1 respectively. As a consequence of this, diminished phosphorylation of Bad occurred along with the decreased Bcl-xL expression. This subsequently enhanced Bax levels permitting the release of mitochondrial cytochrome c into the cytosol which concomitantly activated caspase 9 and caspase 3 resulting apoptotic cell death. Impairment of Akt activation by VCO also deactivated Mdm2 that effected overexpression of p53 which in turn upregulated p21 expression. This causes enhanced p21 binding to cyclin D1 that halted G1 to S phase progression. Taken together, VCO produces two prong effects on lung cancer cells, it induces apoptosis and blocked cancer cell proliferation, both occurred due to the deactivation of Akt. In addition, it has another crucial advantage: VCO could be directly delivered to lung cancer tissue through inhalation.

  16. Ubiquitination in apoptosis signaling

    NARCIS (Netherlands)

    van de Kooij, L.W.

    2014-01-01

    The work described in this thesis focuses on ubiquitination and protein degradation, with an emphasis on how these processes regulate apoptosis signaling. More specifically, our aims were: 1. To increase the understanding of ubiquitin-mediated regulation of apoptosis signaling. 2. To identify the E3

  17. Calpains, mitochondria, and apoptosis.

    Science.gov (United States)

    Smith, Matthew A; Schnellmann, Rick G

    2012-10-01

    Mitochondrial activity is critical for efficient function of the cardiovascular system. In response to cardiovascular injury, mitochondrial dysfunction occurs and can lead to apoptosis and necrosis. Calpains are a 15-member family of Ca(2+)-activated cysteine proteases localized to the cytosol and mitochondria, and several have been shown to regulate apoptosis and necrosis. For example, in endothelial cells, Ca(2+) overload causes mitochondrial calpain 1 cleavage of the Na(+)/Ca(2+) exchanger leading to mitochondrial Ca(2+) accumulation. Also, activated calpain 1 cleaves Bid, inducing cytochrome c release and apoptosis. In renal cells, calpains 1 and 2 promote apoptosis and necrosis by cleaving cytoskeletal proteins, which increases plasma membrane permeability and cleavage of caspases. Calpain 10 cleaves electron transport chain proteins, causing decreased mitochondrial respiration and excessive activation, or inhibition of calpain 10 activity induces mitochondrial dysfunction and apoptosis. In cardiomyocytes, calpain 1 activates caspase 3 and poly-ADP ribose polymerase during tumour necrosis factor-α-induced apoptosis, and calpain 1 cleaves apoptosis-inducing factor after Ca(2+) overload. Many of these observations have been elucidated with calpain inhibitors, but most calpain inhibitors are not specific for calpains or a specific calpain family member, creating more questions. The following review will discuss how calpains affect mitochondrial function and apoptosis within the cardiovascular system.

  18. Game Performance Evaluation in Male Goalball Players

    Directory of Open Access Journals (Sweden)

    Molik Bartosz

    2015-12-01

    Full Text Available Goalball is a Paralympic sport exclusively for athletes who are visually impaired and blind. The aims of this study were twofold: to describe game performance of elite male goalball players based upon the degree of visual impairment, and to determine if game performance was related to anthropometric characteristics of elite male goalball players. The study sample consisted of 44 male goalball athletes. A total of 38 games were recorded during the Summer Paralympic Games in London 2012. Observations were reported using the Game Efficiency Sheet for Goalball. Additional anthropometric measurements included body mass (kg, body height (cm, the arm span (cm and length of the body in the defensive position (cm. The results differentiating both groups showed that the players with total blindness obtained higher means than the players with visual impairment for game indicators such as the sum of defense (p = 0.03 and the sum of good defense (p = 0.04. The players with visual impairment obtained higher results than those with total blindness for attack efficiency (p = 0.04, the sum of penalty defenses (p = 0.01, and fouls (p = 0.01. The study showed that athletes with blindness demonstrated higher game performance in defence. However, athletes with visual impairment presented higher efficiency in offensive actions. The analyses confirmed that body mass, body height, the arm span and length of the body in the defensive position did not differentiate players’ performance at the elite level.

  19. Adapting virtual camera behaviour through player modelling

    DEFF Research Database (Denmark)

    Burelli, Paolo; Yannakakis, Georgios N.

    2015-01-01

    a novel approach to virtual camera control, which builds upon camera control and player modelling to provide the user with an adaptive point-of-view. To achieve this goal, we propose a methodology to model the player’s preferences on virtual camera movements and we employ the resulting models to tailor......Research in virtual camera control has focused primarily on finding methods to allow designers to place cameras effectively and efficiently in dynamic and unpredictable environments, and to generate complex and dynamic plans for cinematography in virtual environments. In this article, we propose...... the viewpoint movements to the player type and her game-play style. Ultimately, the methodology is applied to a 3D platform game and is evaluated through a controlled experiment; the results suggest that the resulting adaptive cinematographic experience is favoured by some player types and it can generate...

  20. There is no game without a player

    DEFF Research Database (Denmark)

    Larsen, Lasse Juel

    on the subject matter from the catalogue of game theory. All four suggestions exclude the player from the relationship. This paper introduces a phenomenological point of view and includes the player in order to understand the relationship between structure and dressing. It argues that players constitute a bridge......This paper is a search for meaning or to be more precise a study of how meaning is produced between ontology and fiction in computer games. It sets out to investigate the relationship between formal abstract game structures and game representation (dressing) by presenting four suggestions...... or the center which establishes, upholds and renegotiate the relationship between formal game structure and game dressing. It also argues that players’ interaction with both structure and dressing produce meaning and the production of meaning is the relationship between formal abstract game structures and game...

  1. Big Data for Business Ecosystem Players

    Directory of Open Access Journals (Sweden)

    Perko Igor

    2016-06-01

    Full Text Available In the provided research, some of the Big Data most prospective usage domains connect with distinguished player groups found in the business ecosystem. Literature analysis is used to identify the state of the art of Big Data related research in the major domains of its use-namely, individual marketing, health treatment, work opportunities, financial services, and security enforcement. System theory was used to identify business ecosystem major player types disrupted by Big Data: individuals, small and mid-sized enterprises, large organizations, information providers, and regulators. Relationships between the domains and players were explained through new Big Data opportunities and threats and by players’ responsive strategies. System dynamics was used to visualize relationships in the provided model.

  2. Motivation and Sport Injuries in Handball Players

    Directory of Open Access Journals (Sweden)

    Laguna, María

    2010-12-01

    Full Text Available The aim of the study was to test whether different levels of motivation are related to the injuries suffered by elite athletes. The sample consists of 80 professional handball players of ASOBAL League, with a mean age of 24.83 years (+ 5.21. Motivation was assessed through the CPRD scale (Gimeno, Buceta & Pérez-Llantada; 1999 and a self-report questionnaire was used to register sports injuries. The results indicate that there is a relationship between motivational levels and the risk for injury. Specifically, players with high motivated players had a greater number of moderate injuries. Although it may seem paradoxical, it is possible that an excessively high motivation leads to overachievement and risk behaviors, which in turn facilitate the appearance of lesions.

  3. Individual recovery profiles in basketball players.

    Science.gov (United States)

    Moreno, Jordi; Ramos-Castro, Juan; Rodas, Gil; Tarragó, Joan R; Capdevila, Lluís

    2015-01-01

    In the sport context, recovery has been characterized as a multifactor process (physiological, psychological, behavioral, social, etc.). This study takes a multidisciplinary approach to find psychophysiological markers of the stress-recovery process. It aims to determine how athletes' specific recovery actions relate to their perceptions of recovery, and Heart Rate Variability (HRV). A total of 196 assessments were analyzed from 6 players on a men's professional basketball team within the Liga LEB Oro basketball federation (2012/2013 season). Perceptions of recovery, recovery strategies, and HRV were recorded. The results show a pattern of individual differences in behavior related to athletes' recovery actions and HRV profiles throughout the season (p < .05). Moreover, we observed that each player had different recovery needs. In light of these results, we suggest an individualistic approach to evaluating and monitoring recovery to attend more accurately to each player's recovery needs.

  4. Modelling Virtual Camera Behaviour Through Player Gaze

    DEFF Research Database (Denmark)

    Picardi, Andrea; Burelli, Paolo; Yannakakis, Georgios N.

    2012-01-01

    In a three-dimensional virtual environment, aspects such as narrative and interaction largely depend on the placement and animation of the virtual camera. Therefore, virtual camera control plays a critical role in player experience and, thereby, in the overall quality of a computer game. Both game...... industry and game AI research focus on the devel- opment of increasingly sophisticated systems to automate the control of the virtual camera integrating artificial intel- ligence algorithms within physical simulations. However, in both industry and academia little research has been carried out...... on the relationship between virtual camera, game-play and player behaviour. We run a game user experiment to shed some light on this relationship and identify relevant dif- ferences between camera behaviours through different game sessions, playing behaviours and player gaze patterns. Re- sults show that users can...

  5. Inhibitor of apoptosis proteins and apoptosis

    Institute of Scientific and Technical Information of China (English)

    Yunbo Wei; Tingjun Fan; Miaomiao Yu

    2008-01-01

    Apoptosis is a physiological cell death process that plays a critical role in development, homeostasis, and immune defense of multicellular animals. Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that possess between one and three baculovirus IAP repeats. Some of them also have a really interesting new gene finger domain, and can prevent cell death by binding and inhibiting active caspases, but are regulated by IAP antagonists. Some evidence also indicates that IAP can modulate the cell cycle and signal transduction. The three main factors, IAPs, IAP antagonists, and caspases, are involved in regulating the progress of apoptosis in many species. Many studies and assumptions have been focused on the anfractuous interactions between these three main factors to explore their real functional model in order to develop potential anticancer drugs.In this review, we describe the classification, molecular structures, and properties of IAPs and discuss the mechanisms of apoptosis. We also discuss the promising significance of clinical applications of IAPs in the diagnosis and treatment of malignancy.

  6. RIP3 induces apoptosis independent of pronecrotic kinase activity.

    Science.gov (United States)

    Mandal, Pratyusha; Berger, Scott B; Pillay, Sirika; Moriwaki, Kenta; Huang, Chunzi; Guo, Hongyan; Lich, John D; Finger, Joshua; Kasparcova, Viera; Votta, Bart; Ouellette, Michael; King, Bryan W; Wisnoski, David; Lakdawala, Ami S; DeMartino, Michael P; Casillas, Linda N; Haile, Pamela A; Sehon, Clark A; Marquis, Robert W; Upton, Jason; Daley-Bauer, Lisa P; Roback, Linda; Ramia, Nancy; Dovey, Cole M; Carette, Jan E; Chan, Francis Ka-Ming; Bertin, John; Gough, Peter J; Mocarski, Edward S; Kaiser, William J

    2014-11-20

    Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease. Here, three selective small-molecule compounds are shown to inhibit RIP3 kinase-dependent necroptosis, although their therapeutic value is undermined by a surprising, concentration-dependent induction of apoptosis. These compounds interact with RIP3 to activate caspase 8 (Casp8) via RHIM-driven recruitment of RIP1 (RIPK1) to assemble a Casp8-FADD-cFLIP complex completely independent of pronecrotic kinase activities and MLKL. RIP3 kinase-dead D161N mutant induces spontaneous apoptosis independent of compound, whereas D161G, D143N, and K51A mutants, like wild-type, only trigger apoptosis when compound is present. Accordingly, RIP3-K51A mutant mice (Rip3(K51A/K51A)) are viable and fertile, in stark contrast to the perinatal lethality of Rip3(D161N/D161N) mice. RIP3 therefore holds both necroptosis and apoptosis in balance through a Ripoptosome-like platform. This work highlights a common mechanism unveiling RHIM-driven apoptosis by therapeutic or genetic perturbation of RIP3.

  7. Effect of game format on heart rate, activity profile, and player involvement in elite and recreational youth players

    DEFF Research Database (Denmark)

    Randers, M B; Andersen, T. Bull; Rasmussen, L S;

    2014-01-01

    The purpose of this study was to evaluate activity profile, aerobic load, and player involvement in two game formats of recreational and elite youth football for two age groups. A total of 152 youth players participated, with 45 U10 players playing 5v5 and 8v8 games, and 41 U13 players playing 8v8...... high in youth football matches irrespective of the level of play and the game format. Playing with fewer players on smaller pitches results...... in minor changes to the physical loading but elevates the technical involvement of youth players both at elite level and recreational level....

  8. Fault Predictive Control of Compact Disk Players

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Wickerhauser, Mladen Victor

    2006-01-01

    Optical disc players such as CD-players have problems playing certain discs with surface faults like scratches and fingerprints. The problem is to be found in the servo controller which positions the optical pick-up, such that the laser beam is focused on the information track. A scheme handling ...... of the feature based control scheme, such that a prediction step is included. The proposed scheme is compared with the feature based control scheme, in the perspective of handling surface faults, by simulations. These simulations show the improvements given by the proposed algorithm....

  9. Caspases: An apoptosis mediator

    Directory of Open Access Journals (Sweden)

    Tapan Kumar Palai

    2015-03-01

    Full Text Available The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy - dependent biochemical mechanisms. Apoptosis is a widely conserved phenomenon helping many processes, including normal cell turnover, proper development and functioning of the immune system, hormone dependent atrophy etc. Inappropriate apoptosis (either low level or high level leads to many developmental abnormalities like, neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. To use cells for therapeutic purposes through generating cell lines, it is critical to study the cell cycle machinery and signalling pathways that controls cell death and apoptosis. Apoptotic pathways provide a fundamental protective mechanism that decreases cellular sensitivity to damaging events and allow proper developmental process in multi-cellular organisms. Major mediator of apoptosis is a family of proteins known as caspases. There are mainly fourteen types of caspases but out of them only ten caspasese have got essential role in controlling the process of apoptosis. These ten caspases have been categorized into either initiator caspases (caspase 2, 8, 9, 10 or executioner caspases (caspase 3, 6, 7. Although various types of caspases have been identified so far, the exact mechanisms of action of these groups of proteins is still to be fully understood. The aim of this review is to provide a detail overview of role of different caspases in regulating the process of apoptosis.

  10. On the Modeling of Honest Players in Reputation Systems

    Institute of Scientific and Technical Information of China (English)

    Qing Zhang; Wei Wei; Ting Yu

    2009-01-01

    Reputation mechanisms are a key technique to trust assessment in large-scale decentralized systems.The effectiveness of reputation-based trust management fundamentally relies on the assumption that an entity's future behavior may be predicted based on its past behavior.Though many reputation-based trust schemes have been proposed,they can offen be easily manipulated and exploited.since an attacker may adapt its behavior.and make the above assumption invalid.In other words.existing trust schemes are in general only effective when applied to honest players who usually act with certain consistency instead of adversaries who can behave arbitrarily.In this paper,we investigate the modeling of honest entities in decentralized systems.We build a statistical model for the transaction histories of honest players.This statistical model serves as a profiling tool to identify suspicious entities.It is combined with existing trust schemes to ensure that they are applied to entities whose transaction records are consistent with the statistical model.This approach limits the manipulation capability of adversaries,and thus can significantly improve the quality of reputation-based trust assessment.

  11. Apoptosis and congestive heart failure.

    Science.gov (United States)

    Feuerstein, G; Ruffolo, R R; Yue, T L

    1997-10-01

    Congestive heart failure (CHF) is the final clinical manifestation of a variety of cardiac (myopathies), coronary (atherosclerosis), and systemic diseases (diabetes, hypertension). Regardless of the origin of the cardiac insult, left ventricular dysfunction resulting in decreased cardiac output elicits a series of adaptational processes that attempt to compensate for some of the decrement in myocardial function. One of the key manifestations of these compensatory processes is cardiac hypertrophy, which is characterized by a marked increase in myocyte size and an increase in contractile proteins. The benefits resulting from these compensatory adaptational mechanisms, however, are only transient, and within a period of months to years, the changes induced in the myocardium fail to sustain cardiac output at a level that is sufficient to meet the demands of the body; subsequently, physical performance is impaired. Typically, progressive dilation and thinning of the left ventricle occur along with progression of CHF. The mechanisms responsible for the thinning of ventricular tissue and loss of left ventricular mass are poorly understood; traditionally, such loss has been attributed to tissue necrosis based on the morphologic observation of dead cardiac myocytes. Very recently, there have been data suggesting that apoptosis, a form of programmed cell death (PCD), occurs in the heart and may be responsible, at least in part, for the progression of CHF and the chronic loss of left ventricular function and mass. Evidence for a role of apoptosis/PCD in the progression of heart failure has been obtained from a variety of observations, including in vitro studies of cardiac myocytes in culture, experimental animal models of cardiac injury, and cardiac tissue obtained from patients with CHF. Thus, apoptosis/PCD may be a critical mechanism involved in the progressive loss of cardiac myocytes, which ultimately results in end-stage heart failure. In this brief review, the evidence

  12. Short Duration Heat Acclimation in Australian Football Players

    Science.gov (United States)

    Kelly, Monica; Gastin, Paul B.; Dwyer, Daniel B; Sostaric, Simon; Snow, Rodney J.

    2016-01-01

    This study examined if five sessions of short duration (27 min), high intensity, interval training (HIIT) in the heat over a nine day period would induce heat acclimation in Australian football (AF) players. Fourteen professional AF players were matched for VO2peak (mL·kg-1·min-1) and randomly allocated into either a heat acclimation (Acc) (n = 7) or Control (Con) group (n = 7). The Acc completed five cycle ergometer HIIT sessions within a nine day period on a cycle ergometer in the heat (38.7 ± 0.5 °C; 34.4 ± 1.3 % RH), whereas Con trained in thermo-neutral conditions (22.3 ± 0.2 °C; 35.8 ± 0. % RH). Four days prior and two days post HIIT participants undertook a 30 min constant load cycling test at 60% V̇O2peak in the heat (37.9 ± 0.1 °C; 28.5 ± 0.7 % RH) during which VO2, blood lactate concentration ([Lac-]), heart rate (HR), rating of perceived exertion (RPE), thermal comfort, core and skin temperatures were measured. Heat acclimation resulted in reduced RPE, thermal comfort and [Lac-] (all p HIIT, in both groups. Heat acclimation did not influence any other measured variables. In conclusion, five short duration HIIT sessions in hot dry conditions induced limited heat acclimation responses in AF players during the in-season competition phase. In practice, the heat acclimation protocol can be implemented in a professional team environment; however the physiological adaptations resulting from such a protocol were limited. Key points Some minor heat acclimation adaptations can be induced in professional AF players with five 27 min non-consecutive, short duration HIIT sessions in the heat. The heat acclimation protocol employed in this study was able to be implemented in a professional team sport environment during an actual competitive season. Elevating and maintaining a high core temperature sufficient for heat acclimation likely requires a longer heat training session or some pre-heating prior to exercise. PMID:26957934

  13. Apoptosis in Drosophila: which role for mitochondria?

    Science.gov (United States)

    Clavier, Amandine; Rincheval-Arnold, Aurore; Colin, Jessie; Mignotte, Bernard; Guénal, Isabelle

    2016-03-01

    It is now well established that the mitochondrion is a central regulator of mammalian cell apoptosis. However, the importance of this organelle in non-mammalian apoptosis has long been regarded as minor, mainly because of the absence of a crucial role for cytochrome c in caspase activation. Recent results indicate that the control of caspase activation and cell death in Drosophila occurs at the mitochondrial level. Numerous proteins, including RHG proteins and proteins of the Bcl-2 family that are key regulators of Drosophila apoptosis, constitutively or transiently localize in mitochondria. These proteins participate in the cell death process at different levels such as degradation of Diap1, a Drosophila IAP, production of mitochondrial reactive oxygen species or stimulation of the mitochondrial fission machinery. Here, we review these mitochondrial events that might have their counterpart in human.

  14. DNA fragmentation in apoptosis

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Cleavage of chromosomal DNA into oligonucleosomal size fragments is an integral part of apoptosis. Elegant biochemical work identified the DNA fragmentation factor (DFF) as a major apoptotic endonuclease for DNA fragmentation in vitro. Genetic studies in mice support the importance of DFF in DNA fragmentation and possibly in apoptosis in vivo. Recent work also suggests the existence of additional endonucleases for DNA degradation. Understanding the roles of individual endonucleases in apoptosis, and how they might coordinate to degrade DNA in different tissues during normal development and homeostasis, as well as in various diseased states, will be a major research focus in the near future.

  15. Jet Lag a Drag on Pro Baseball Players

    Science.gov (United States)

    ... 163187.html Jet Lag a Drag on Pro Baseball Players Study found traveling across time zones linked ... might be more than just tiring for pro baseball players: The resulting jet lag may actually harm ...

  16. Role of PUMA in methamphetamine-induced neuronal apoptosis.

    Science.gov (United States)

    Chen, Chuanxiang; Qincao, Litao; Xu, Jingtao; Du, Sihao; Huang, Enping; Liu, Chao; Lin, Zhoumeng; Xie, Wei-Bing; Wang, Huijun

    2016-01-05

    Exposure to methamphetamine (METH), a widely used illicit drug, has been shown to cause neuron apoptosis. p53 upregulated modulator of apoptosis (PUMA) is a key mediator in neuronal apoptosis. This study aimed to examine the effects of PUMA in METH-induced neuronal apoptosis. We determined PUMA protein expression in PC12 cells and SH-SY5Y cells after METH exposure using western blot. We also observed the effect of METH on neuronal apoptosis after silencing PUMA expression with siRNA using TUNEL staining and flow cytometry. Additionally, to investigate possible mechanisms of METH-induced PUMA-mediated neuronal apoptosis, we measured the protein expression of apoptotic markers, including cleaved caspase-3, cleaved PARP, Bax, B-cell leukemia/lymphoma-2 (Bcl-2) and cytochrome c (cyto c), after METH treatment with or without PUMA knockdown. Results showed that METH exposure induced cell apoptosis, increased PUMA protein levels, activated caspase-3 and PARP, elevated Bax and reduced Bcl-2 expression, as well as increased the release of cyto c from mitochondria to the cytoplasm in both PC12 and SH-SY5Y cells. All these effects were attenuated or reversed after silencing PUMA. A schematic depicting the role of PUMA in METH-induced mitochondrial apoptotic pathway was proposed. Our results suggest that PUMA plays an important role in METH-triggered apoptosis and it may be a potential target for ameliorating neuronal injury and apoptosis caused by METH.

  17. Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma.

    Directory of Open Access Journals (Sweden)

    Pascal Gelebart

    Full Text Available Fatty acid synthase (FASN, a key player in the de novo synthetic pathway of long-chain fatty acids, has been shown to contribute to the tumorigenesis in various types of solid tumors. We here report that FASN is highly and consistently expressed in mantle cell lymphoma (MCL, an aggressive form of B-cell lymphoid malignancy. Specifically, the expression of FASN was detectable in all four MCL cell lines and 15 tumors examined. In contrast, benign lymphoid tissues and peripheral blood mononuclear cells from normal donors were negative. Treatment of MCL cell lines with orlistat, a FASN inhibitor, resulted in significant apoptosis. Knockdown of FASN expression using siRNA, which also significantly decreased the growth of MCL cells, led to a dramatic decrease in the cyclin D1 level. β-catenin, which has been previously reported to be upregulated in a subset of MCL tumors, contributed to the high level of FASN in MCL cells, Interesting, siRNA knock-down of FASN in turn down-regulated β-catenin. In conclusion, our data supports the concept that FASN contributes to the pathogenesis of MCL, by collaborating with β-catenin. In view of its high and consistent expression in MCL, FASN inhibitors may hold promises for treating MCL.

  18. Kinanthropometric characteristics in teenager basketball players

    Directory of Open Access Journals (Sweden)

    Maria Abella del Campo

    2015-12-01

    Full Text Available Introduction: Basketball is a sport with a high heterogeneity anthropometric as playing position. Point guard is usually the lowest player but also the fastest. Guard is similar to point guard, faster and more agile than the others. Small forward has an intermediate height between the inside and outside players and it combines height with velocity. And center (pivot has a physical role, it has the highest and more muscle mass. The aim of this study is to describe the kinanthropometric profile of male cadet “Valencia Basket Club”. Material and Methods: A total of 20 male cadet basketball players were evaluated (15.35±0.59 years old. An anthropometrist level 1 took anthropometric measures according to the methodology of the International Society for the Advancement of Kinanthropometry (ISAK. Body composition was calculated according to the kinanthropometry consensus of the Kinanthropometry Spanish Group (GREC, somatotype with Heath-Carter’s method and adiposemuscular and cardiovascular risk index. Results: Differences in values of weight, height, skinfold and body composition from variables of sample and position were observed. Lower values were from point guard position and higher values were from center position. An increasing trend of these parameters was established in the following order: point guard, guard, small forward and center. Conclusions: The Valencia Basket Club cadet player overall somatotype is balance ectomorph. To know kinanthropometric profile may be beneficial to develop specific training and nutrition plans as well as to see evolution and characteristics for optimal performance

  19. Soccer Skill Development in Talented Players

    NARCIS (Netherlands)

    Huijgen, B. C. H.; Elferink-Gemser, M. T.; Ali, A.; Visscher, C.

    2013-01-01

    The aim of the study was to gain insight into the development of soccer-specific skills and whether differences between talented players exist on the Loughborough Soccer Passing Test (LSPT). Two scores were derived from the LSPT: 1) execution time: time to complete 16 passes (speed) and 2) skill per

  20. Mental rotation performance in male soccer players.

    Directory of Open Access Journals (Sweden)

    Petra Jansen

    Full Text Available It is the main goal of this study to investigate the visual-spatial cognition in male soccer players. Forty males (20 soccer players and 20 non-athletes solved a chronometric mental rotation task with both cubed and embodied figures (human figures, body postures. The results confirm previous results that all participants had a lower mental rotation speed for cube figures compared to embodied figures and a higher error rate for cube figures, but only at angular disparities greater than 90°. It is a new finding that soccer-players showed a faster reaction time for embodied stimuli. Because rotation speed did not differ between soccer-players and non-athletes this finding cannot be attributed to the mental rotation process itself but instead to differences in one of the following processes which are involved in a mental rotation task: the encoding process, the maintanence of readiness, or the motor process. The results are discussed against the background of the influence on longterm physical activity on mental rotation and the context of embodied cognition.

  1. Addressing Competitive Stress in Junior Tennis Players.

    Science.gov (United States)

    Dunlap, Patricia; Berne, Linda A.

    1991-01-01

    The PRECEDE model (an acronym for predisposing, reinforcing, and enabling causes in education diagnosis and evaluation) emphasizes outcomes rather than inputs. The model was used in assessing the health needs of nationally ranked junior tennis players. The objective was to reduce stress illness in high-level competition. (JD)

  2. Apoptosis in Pneumovirus Infection

    Directory of Open Access Journals (Sweden)

    Reinout A. Bem

    2013-01-01

    Full Text Available Pneumovirus infections cause a wide spectrum of respiratory disease in humans and animals. The airway epithelium is the major site of pneumovirus replication. Apoptosis or regulated cell death, may contribute to the host anti-viral response by limiting viral replication. However, apoptosis of lung epithelial cells may also exacerbate lung injury, depending on the extent, the timing and specific location in the lungs. Differential apoptotic responses of epithelial cells versus innate immune cells (e.g., neutrophils, macrophages during pneumovirus infection can further contribute to the complex and delicate balance between host defense and disease pathogenesis. The purpose of this manuscript is to give an overview of the role of apoptosis in pneumovirus infection. We will examine clinical and experimental data concerning the various pro-apoptotic stimuli and the roles of apoptotic epithelial and innate immune cells during pneumovirus disease. Finally, we will discuss potential therapeutic interventions targeting apoptosis in the lungs.

  3. Training Patterns of Wheelchair Basketball Players in Turkey

    Science.gov (United States)

    Tatar, Yasar

    2008-01-01

    The aim of this study was to analyze technical drills, warm-up and cool-down exercises used by wheelchair basketball players of the Turkish league in relation to training sessions. 33 male wheelchair basketball players participated in the study (mean age 26.6[plus or minus]5,95 years). All players reported that they used warm-up exercises before…

  4. Automatic player detection and identification for sports entertainment applications

    NARCIS (Netherlands)

    Mahmood, Zahid; Ali, Tauseef; Khattak, Shadid; Hasan, Laiq; Khan, Samee U.

    2014-01-01

    In this paper, we develop an augmented reality sports broadcasting application for automatic detection, recognition of players during play, followed by display of personal information of players. The proposed application can be divided into four major steps. In first step, each player in the image i

  5. Assessment of Cardiovascular Risk in Collegiate Football Players and Nonathletes

    Science.gov (United States)

    Dobrosielski, Devon A.; Rosenbaum, Daryl; Wooster, Benjamin M.; Merrill, Michael; Swanson, John; Moore, J. Brian; Brubaker, Peter H.

    2010-01-01

    Collegiate American football players may be at risk for cardiovascular disease. Objective: To compare cardiovascular disease risk factors and cardiovascular structure and function parameters of football players, stratified by position, to a group of sedentary, nonathletes. Participants: Twenty-six collegiate football players and 13 nonathletes…

  6. Synthetic Players: A Quest for Artificial Intelligence in Computer Games

    Directory of Open Access Journals (Sweden)

    Jouni Smed

    2005-03-01

    Full Text Available Synthetic players are the computer-controlled actors in a computer game. In this paper, we describe both the implementation issues and the behavioural expectations related to synthetic players. We recognize the role of synthetic players by analysing the components of games in general and computer games in particular.

  7. Understanding the Mismatch Between Coaches' and Players' Perceptions of Exertion

    NARCIS (Netherlands)

    Brink, Michel S; Kersten, Anna W; Frencken, Wouter G

    2016-01-01

    A mismatch between the intended training exertion by the coach and the perceived exertion by players is well established in sports. However, it is unknown if coaches are able to accurately observe exertion of individual players during training. Furthermore, the discrepancy in coaches' and players' p

  8. Dynamic Difficulty Balancing for Cautious Players and Risk Takers

    Directory of Open Access Journals (Sweden)

    Guy Hawkins

    2012-01-01

    Full Text Available Dynamic balancing of game difficulty can help cater for different levels of ability in players. However, performance in some game tasks depends on not only the player's ability but also their desire to take risk. Taking or avoiding risk can offer players its own reward in a game situation. Furthermore, a game designer may want to adjust the mechanics differently for a risky, high ability player, as opposed to a risky, low ability player. In this work, we describe a novel modelling technique known as particle filtering which can be used to model various levels of player ability while also considering the player's risk profile. We demonstrate this technique by developing a game challenge where players are required to make a decision between a number of possible alternatives where only a single alternative is correct. Risky players respond faster but with more likelihood of failure. Cautious players wait longer for more evidence, increasing their likelihood of success, but at the expense of game time. By gathering empirical data for the player's response time and accuracy, we develop particle filter models. These models can then be used in real-time to categorise players into different ability and risk-taking levels.

  9. Electromyographic assessment of forearm muscle function in tennis players with and without Lateral Epicondylitis.

    Science.gov (United States)

    Alizadehkhaiyat, Omid; Frostick, Simon P

    2015-12-01

    There is no consensus about the main aetiology of Lateral Epicondylitis (LE) or Tennis Elbow. While electromyographic assessment of alterations in neuromuscular control and activation patterns of forearm muscles has received increasing interest as potential intrinsic factors in non-tennis players, there has been insufficient attention in tennis players. The purpose of present review was to search the literature for the electromyographic studies of forearm muscles in tennis players in order to (1) identify related implications for LE, (2) highlight key technical and methodological shortcomings, and (3) suggest potential pathways for future research. An electronic search of PubMed, Scopus, Web of Science, and Google Scholars (1980 to October 2014) was conducted. Titles, abstracts, and full-text articles were screened to identify "peer-reviewed" studies specifically looking into "electromyographic assessment of forearm muscles" in "tennis players". After screening 104 articles, 13 original articles were considered in the main review involving a total of 216 participants (78% male, 22% female). There were indications of increased wrist extensor activity in all tennis strokes and less experienced single-handed players, however with insufficient evidence to support their relationship with the development of LE. Studies varied widely in study population, sample size, gender, level of tennis skills, electrode type, forearm muscles studied, EMG recording protocol, EMG normalisation method, and reported parameters. As a result, it was not possible to present combined results of existing studies and draw concrete conclusions in terms of clinical implications of findings. There is a need for establishment of specific guidelines and recommendations for EMG assessment of forearm musculature particularly in terms of electrode and muscle selection. Further studies of both healthy controls and tennis players suffering from LE with adequate sample sizes and well-defined demographics

  10. The role of shoulder maximum external rotation during throwing for elbow injury prevention in baseball players.

    Science.gov (United States)

    Miyashita, Koji; Urabe, Yukio; Kobayashi, Hirokazu; Yokoe, Kiyoshi; Koshida, Sentaro; Kawamura, Morio; Ida, Kunio

    2008-01-01

    The objective of the present study was to examine whether the passive range of shoulder external rotation (ER), the maximum shoulder external rotation angle (MER) during throwing, and the ratio of MER to ER are related to the incidence of the elbow injury. A mixed design with one between-factor (a history of the elbow injury) and two within-factors (ER and MER) was used to analyze the difference between baseball players with and without a history of medial elbow pain. Twenty high school baseball players who had experienced the medial elbow pain within the previous month but who were not experiencing the pain on the day of the experiment were recruited (elbow-injured group). Another twenty baseball players who had never experienced the medial elbow pain were also used for testing (control group). MER during throwing, ER, and the ratio of MER to ER were obtained in both of the group. A Mann-Whitney test was used for the group comparison (p baseball players. Key pointsIt is accepted that the greatest elbow valgus stress appears at the position of shoulder maximum external rotation (MER) in the acceleration phase of the throwing movement. As a consequence, shoulders with restricted range of motion of external rotation (ER) compensate with a valgus stress on their elbow joints.In this study, we evaluated the relation between MER and ER of shoulder in players with/without elbow injuries.The result of this study demonstrated that the elbow injured group showed significantly greater MER/ER relation than the control group.The current finding suggests that great MER combined with the ROM restriction may be one of the risk factors to cause medial elbow pain in baseball players.

  11. Football players, asset management & the unexploited potential of enhanced player engagement in football management & marketing

    DEFF Research Database (Denmark)

    Cortsen, Kenneth

    2014-01-01

    This article gives insights into why and how football brands (e.g. clubs and governing bodies) can benefit from enhancing the activation of players in football management and football marketing initiatives.......This article gives insights into why and how football brands (e.g. clubs and governing bodies) can benefit from enhancing the activation of players in football management and football marketing initiatives....

  12. Dynamic Visual Acuity Training in Cricket Players

    Directory of Open Access Journals (Sweden)

    Renee Edgar, B.Optom

    2015-04-01

    Full Text Available Background: Dynamic visual acuity (DVA is the ability of an observer to correctly identify details of a moving target and is considered to be important for tasks like driving. Dynamic Visual Acuity is better in athletes involved in sports such as basketball and baseball; however, no previous studies have considered the sport of cricket. We conducted a study to determine whether there was any difference in DVA between cricket and non-cricket players. Method: Dynamic visual acuity was measured by asking subjects to identify the orientation of the gap of a moving Landolt C target as a four-alternative forced-choice task. The Landolt C targets had confusion bars surrounding them. The participants in the study were tested twice with a break of seven weeks. In between the two measurements, participants underwent two training sessions (similar to the testing sessions, each three weeks apart. Results: The initial mean DVA for cricket players was 107.7 deg/sec, and the mean DVA for non-cricket players was 105.5 deg/sec, with a target size of 6/15. The subjects who participated in training (cricketers and non-cricketers improved in DVA by 41 deg/sec in contrast to the improvement in the non-training subjects of 18 deg/sec (p=0.0032. The cricketers who participated in the training improved in DVA by 44 deg/sec, whereas the cricketers who did not participate in the training improved by 19 deg/sec (p=0.0167. Conclusions: We found no significant difference in initial DVA between the cricket players and the non-cricket players. The training resulted in an extremely significant improvement in DVA performance by both the cricketers and non-cricketers.

  13. The architecture of the chess player's brain.

    Science.gov (United States)

    Hänggi, Jürgen; Brütsch, Karin; Siegel, Adrian M; Jäncke, Lutz

    2014-09-01

    The game of chess can be seen as a typical example for an expertise task requiring domain-specific training and experience. Despite intensive behavioural studies the neural underpinnings of chess performance and expertise are not entirely understood. A few functional neuroimaging studies have shown that expert chess players recruit different psychological functions and activate different brain areas while they are engaged in chess-related activities. Based on this functional literature, we predicted to find morphological differences in a network comprised by parietal and frontal areas and especially the occipito-temporal junction (OTJ), fusiform gyrus, and caudate nucleus. Twenty expert chess players and 20 control subjects were investigated using voxel-based and surface-based morphometry as well as diffusion tensor imaging. Grey matter volume and cortical thickness were reduced in chess players compared with those of control men in the OTJ and precunei. The volumes of both caudate nuclei were not different between groups, but correlated inversely with the years of chess playing experience. Mean diffusivity was increased in chess players compared with that of controls in the left superior longitudinal fasciculus and the Elo score (a chess tournament ranking) was inversely related to mean diffusivity within the right superior longitudinal fasciculus. To the best of our knowledge we showed for the first time that there are specific differences in grey and white matter morphology between chess players and control subjects in brain regions associated with cognitive functions important for playing chess. Whether these anatomical alterations are the cause or consequence of the intensive and long-term chess training and practice remains to be shown in future studies.

  14. Long-term training-induced changes in sprinting speed and sprint momentum in elite rugby union players.

    Science.gov (United States)

    Barr, Matthew J; Sheppard, Jeremy M; Gabbett, Tim J; Newton, Robert U

    2014-10-01

    Speed and sprint momentum are considered to be important physical qualities for rugby. The purpose of the study was to understand the development of these qualities in senior and junior international rugby players. In part 1 of the study, a group of senior (n = 38) and junior (n = 31) players were tested for speed over 40 m. Initial sprint velocity (ISV), maximal sprint velocity (MSV), initial sprint momentum (ISM), and maximal sprint momentum (MSM) were calculated using 10-m splits. In part 2 of the study, a group of junior (n = 12) and senior (n = 15) players were tracked over a 2-year period for body mass, ISV, MSV, ISM, and MSM. In part 1, senior backs and forwards were not found to have significantly greater ISV and MSV than junior players but were found to have greater ISM and MSM. Forwards were found to have significantly greater ISM and MSM than backs but significantly lower ISV and MSV than backs. In part 2, no significant differences were found over the 2 years between senior and junior players, but greater effect sizes for juniors were generally found when compared with seniors for improvements in ISV (d = 0.73 vs. 0.79), MSV (d = 1.09 vs. 0.68), ISM (d = 0.96 vs. 0.54), and MSM (d = 1.15 vs. 0.50). Sprint momentum is a key discriminator between senior and junior players, and large changes can be made by junior players as they transition into senior rugby. Speed appears to peak for players in their early 20s but sprint momentum appears to be more trainable.

  15. Positioning and deciding : key factors for talent development in soccer

    NARCIS (Netherlands)

    Kannekens, R.; Elferink-Gemser, M. T.; Visscher, C.

    2011-01-01

    Talent identification and development implicate recognizing youth players who will be successful in the future and guiding them to the top. A major determinant of this success is tactical skills. To identify possible key factors that help in predicting success over time, this study assesses the tact

  16. Does competitive entry structurally change key marketing metrics?

    NARCIS (Netherlands)

    Kornelis, Marcel; Dekimpe, Marnik G.; Leeflang, Peter S. H.

    2008-01-01

    To what extent does competitive entry create a structural change in key marketing metrics? New players mayjust be a temporal nuisance to incumbents, but could also fundamentally change the latter's performance evolution, or induce them to permanently alter their spending levels and/or pricing decisi

  17. Verbal communication of story facilitators in multi-player role-playing games

    DEFF Research Database (Denmark)

    Tychsen, Anders; Brolund, Thea; Hitchens, Michael

    2008-01-01

    Multi-player role-playing games form one of the key examples of interactive, emergent and collaborative storytelling systems available. These games and the collaborative stories that they create, are commonly facilitated by a specialized participant, the game master. In the current study, the ver......Multi-player role-playing games form one of the key examples of interactive, emergent and collaborative storytelling systems available. These games and the collaborative stories that they create, are commonly facilitated by a specialized participant, the game master. In the current study......, the verbal communication of game masters in a series of role-playing game sessions is categorized and analyzed depending on form and content, using protocol analysis, establishing a model for the verbal communication of game masters. © 2008 Springer Berlin Heidelberg....

  18. Multi-Player and Multi-Choice Quantum Game

    Institute of Scientific and Technical Information of China (English)

    杜江峰; 李卉; 许晓栋; 周先意; 韩荣典

    2002-01-01

    We investigate a multi-player and multi-choice quantum game. We start from a two-player and two-choice game,and the result is better than its classical version. Then we extend this to N-player and N-choice cases. In the quantum domain, we provide a strategy with which players can always avoid the worst outcome. Also, by changing the value of the parameter of the initial state, the probabilities for players to obtain the best pay-off will be much higher than in its classical version.

  19. The effect of moderate and high-intensity fatigue on groundstroke accuracy in expert and non-expert tennis players.

    Science.gov (United States)

    Lyons, Mark; Al-Nakeeb, Yahya; Hankey, Joanne; Nevill, Alan

    2013-01-01

    using ecologically valid designs that mimic more closely the demands of match play. Key PointsGroundstroke accuracy under moderate-intensity fatigue is equivalent to performance at rest.Groundstroke accuracy declines significantly in both expert (40.3% decline) and non-expert (49.6%) tennis players following high-intensity fatigue.Expert players are more consistent, hit more accurate shots and fewer out shots across all fatigue intensities.The effects of fatigue on groundstroke accuracy are the same regardless of gender and player's achievement goal indicators.

  20. Reduced attentional capture in action video game players.

    Science.gov (United States)

    Chisholm, Joseph D; Hickey, Clayton; Theeuwes, Jan; Kingstone, Alan

    2010-04-01

    Recent studies indicate that playing action video games improves performance on a number of attention-based tasks. However, it remains unclear whether action video game experience primarily affects endogenous or exogenous forms of spatial orienting. To examine this issue, action video game players and non-action video game players performed an attentional capture task. The results show that action video game players responded quicker than non-action video game players, both when a target appeared in isolation and when a salient, task-irrelevant distractor was present in the display. Action video game players additionally showed a smaller capture effect than did non-action video game players. When coupled with the findings of previous studies, the collective evidence indicates that extensive experience with action video games may enhance players' top-down attentional control, which, in turn, can modulate the negative effects of bottom-up attentional capture.

  1. Recognition accuracy by experienced men and women players of basketball.

    Science.gov (United States)

    Millslagle, Duane G

    2002-08-01

    This study examined 30 experienced basketball players' recognition accuracy by sex, playing position (guard, forward, and center), and situations in the game of basketball. The study used a perceptual cognitive paradigm in which subjects viewed slides of structured and unstructured game situations and accurately recognized the presence or absence of the basketball. A significant difference in recognition accuracy by sex, players' position, and structure of the game situation was found. Male players' recognition accuracy was better than the female players'. The recognition accuracy of subjects who played guard was better than that of subjects who played forward or center. The players' recognition accuracy was more accurate when observing structured plays versus unstructured plays. The conclusion of this study suggested that experienced basketball players differ in their cognitive and visual searching processes by sex and player position within the sport of basketball.

  2. Identification af explosive power factors as predictors of player quality in young female volleyball players.

    Science.gov (United States)

    Grgantov, Zoran; Milić, Mirjana; Katić, Ratko

    2013-05-01

    With the purpose of determining the factor structure of explosive power, as well as the influence of each factor on situational efficiency, 56 young female volleyball players were tested using 14 tests for assessing nonspecific and specific explosive power. By factor analysis, 4 significant factors were isolated which explained the total of over 80% of the common variability in young female volleyball players. The first factor was defined as volleyball-specific jumping, the second factor as nonspecific jumping and sprinting, the third factor as throwing explosive power, while the fourth factor was interpreted as volleyball-specific throwing and spiking speed from the ground. Results obtained by regression analysis in the latent space of explosive power indicate that the identified factors are good predictors of player quality in young female volleyball players. The fourth factor defined as throwing and spiking speed from the ground had the largest influence on player quality, followed by volleyball-specific jumping and nonspecific jumping and sprinting, and to a much lesser extent, by throwing explosive power The results obtained in this age group bring to the fore the ability of spiking and serving a ball of high speed, which hinders the opponents from playing those balls in serve reception and field defence. This ability, combined with a high standing vertical jump reach and spike approach vertical jump reach (which is the basis of the 1st varimax factor) enables successful performance of all volleyball elements by which points are won in complex 1 (spike) and complex 2 (serve and block). Even though the 2nd factor (nonspecific jumping and sprinting) has a slightly smaller impact on situational efficiency in young players, this ability provides preconditions i.e. preparation for successful realisation of all volleyball elements, so greater attention must be paid to perfecting it in young female volleyball players.

  3. Exploring Team Passing Networks and Player Movement Dynamics in Youth Association Football.

    Science.gov (United States)

    Gonçalves, Bruno; Coutinho, Diogo; Santos, Sara; Lago-Penas, Carlos; Jiménez, Sergio; Sampaio, Jaime

    2017-01-01

    Understanding how youth football players base their game interactions may constitute a solid criterion for fine-tuning the training process and, ultimately, to achieve better individual and team performances during competition. The present study aims to explore how passing networks and positioning variables can be linked to the match outcome in youth elite association football. The participants included 44 male elite players from under-15 and under-17 age groups. A passing network approach within positioning-derived variables was computed to identify the contributions of individual players for the overall team behaviour outcome during a simulated match. Results suggested that lower team passing dependency for a given player (expressed by lower betweenness network centrality scores) and high intra-team well-connected passing relations (expressed by higher closeness network centrality scores) were related to better outcomes. The correlation between the dyads' positioning regularity and the passing density showed a most likely higher correlation in under-15 (moderate effect), indicating a possible more dependence of the ball position rather than in the under-17 teams (small/unclear effects). Overall, this study emphasizes the potential of coupling notational analyses with spatial-temporal relations to produce a more functional and holistic understanding of teams' sports performance. Also, the social network analysis allowed to reveal novel key determinants of collective performance.

  4. Rehabilitation protocol for patellar tendinopathy applied among 16- to 19-year old volleyball players.

    Science.gov (United States)

    Biernat, Ryszard; Trzaskoma, Zbigniew; Trzaskoma, Lukasz; Czaprowski, Dariusz

    2014-01-01

    The aim of the study was to investigate the efficacy of rehabilitation protocol applied during competitive period for the treatment of patellar tendinopathy. A total of 28 male volleyball players were divided into two groups. Fifteen from experimental group (E) and 13 from control group (C) fulfilled the same tests 3 times: before the training program started (first measurement), after 12 weeks (second measurement) and after 24 weeks (third measurement). The above-mentioned protocol included the following: USG imagining with color Doppler function, clinical testing, pain intensity evaluation with VISA-P questionnaire, leg muscle strength and power and jumping ability measurements. The key element of the rehabilitation program was eccentric squat on decline board with additional unstable surface. The essential factor of the protocol was a set of preventive functional exercises, with focus on eccentric exercises of hamstrings. Patellar tendinopathy was observed in 18% of the tested young volleyball players. Implementation of the presented rehabilitation protocol with eccentric squat on decline board applied during sports season lowered the pain level of the young volleyball players. Presented rehabilitation protocol applied without interrupting the competitive period among young volleyball players together with functional exercises could be an effective method for the treatment of patellar tendinopathy.

  5. DECISION-MAKING OF SPANISH FEMALE BASKETBALL TEAM PLAYERS WHILE THEY ARE COMPETING

    Directory of Open Access Journals (Sweden)

    Ana Concepci\\u00F3n Jim\\u00E9nez S\\u00E1nchez

    2009-01-01

    Full Text Available Decision-making play a very important role in basketball. While the game is taking place, players are constantly choosing what to do. In order to carry out this research work, two questions have been formulated: 1 how do high level female basketball players make a decision while they are competing? 2 which key components do they use to make the best decisions? The twelve players who make up the Spanish female basketball team have taken part in this project. They all participated in the 2008 FIBA World Olympic Qualifying Tournament, which took place in Madrid. This tournament allowed them to qualify and take part in the 2008 Olympic Games, where they finished in fifth place. A questionnaire and an interview have been used to make this research possible. The matches of the 2008 FIBA World Olympic Qualifying Tournament have also been analyzed. Those aspects in terms of the team's performance in 1x1 and 2x2 attack situations, and more specifically in pick actions, have been recorded and analyzed. In order to include these data, a system of specific categories and variables has been established. The results show that players are expert on making decisions during the competition. In order to come to this conclusion, their opinions, style of decision-making, as well as the way they move in 1x1 and 2x2 situations, were very useful. This research has also confirmed that decisions made by playmakers, forwards and centers are different.

  6. Exploring Team Passing Networks and Player Movement Dynamics in Youth Association Football

    Science.gov (United States)

    Coutinho, Diogo; Santos, Sara; Lago-Penas, Carlos; Jiménez, Sergio; Sampaio, Jaime

    2017-01-01

    Understanding how youth football players base their game interactions may constitute a solid criterion for fine-tuning the training process and, ultimately, to achieve better individual and team performances during competition. The present study aims to explore how passing networks and positioning variables can be linked to the match outcome in youth elite association football. The participants included 44 male elite players from under-15 and under-17 age groups. A passing network approach within positioning-derived variables was computed to identify the contributions of individual players for the overall team behaviour outcome during a simulated match. Results suggested that lower team passing dependency for a given player (expressed by lower betweenness network centrality scores) and high intra-team well-connected passing relations (expressed by higher closeness network centrality scores) were related to better outcomes. The correlation between the dyads’ positioning regularity and the passing density showed a most likely higher correlation in under-15 (moderate effect), indicating a possible more dependence of the ball position rather than in the under-17 teams (small/unclear effects). Overall, this study emphasizes the potential of coupling notational analyses with spatial-temporal relations to produce a more functional and holistic understanding of teams’ sports performance. Also, the social network analysis allowed to reveal novel key determinants of collective performance. PMID:28141823

  7. Personal and sports variables and injuries in handball players: A descriptive analysis

    Directory of Open Access Journals (Sweden)

    Aurelio Olmedilla Zafra

    2011-01-01

    Full Text Available AbstractThe aim of this work is to relate some of the personal variables (age and experience and sports (post game, sport category more important with injuries to players of handball. The study sample consisted of 100 handball players, with a mean age of 23.92 years (+ 5.21, of which 80% ASOBAL (Association Handball clubs in Spain competed in the league, and the other 20% did so between first and second division. For the evaluation of the variables using a self-report questionnaire in two parts: the first data is collected and sports personality variables, and the second will collect data on sports injuries. The results of this study indicate that the players suffer more injuries on average 2 in a season, with these minor fractures, muscle and tendinitis, being the player's quinces ASOBAL more is injured. The pivots and lateral suffer more injuries than the rest, and the porters seem to have a significantly lower tendency to injure anyone else. The older the greater the likelihood of injury. The completion of jobs that can determine the exact weight of each variable in the injury, which would be very important from prevention, and the performance of their own coaches.Key words: Sports injuries, handball, age, experience, post game, sport category

  8. S-nitrosylation/Denitrosylation and Apoptosis of Immune Cells

    Institute of Scientific and Technical Information of China (English)

    Shaojin Duan; Chang Chen

    2007-01-01

    Nitric oxide (NO) as an immunoregulatory molecule, predominantly depending on S-nitrosylation, acts as a versatile player that executes its regulation and signal transduction for exerting its multi-functions and pleiotropy.Apoptosis of immune cells is an intricate process coupled with positive/negative selection depending on integrated diverse endogenous and exogenous signals and functions to sustain homeostasis in the immune system. Here, the dual roles of NO depending on its concentration in apoptosis are reviewed, breeding up a switch mode in the apoptotic process. Following comments of different switches from apoptosis-death, a new finding of checkpoint(early fluorescence point) of GSNO-initiated thymocyte apoptosis and NOS-GSNOR double control are highlighted.Moreover, S-nitrosylation/denitrosylation, being as a redox switch, logically approaches to networks of metabolism itself and further accesses the neuroendicrine-immune-free radical network as a whole. Moreover, the host defense mediated by NO on pathogens, via protein S-nitrosylation are also discussed.

  9. Towards Generic Models of Player Experience

    DEFF Research Database (Denmark)

    Shaker, Noor; Shaker, Mohammad; Abou-Zleikha, Mohamed

    2015-01-01

    -dependent and their applicability is usually limited to the system and the data used for model construction. Establishing models of user experience that are highly scalable while maintaing the performance constitutes an important research direction. In this paper, we propose generic models of user experience in the computer games...... further examine whether generic features of player be- haviour can be defined and used to boost the modelling per- formance. The accuracies obtained in both experiments in- dicate a promise for the proposed approach and suggest that game-independent player experience models can be built.......Context personalisation is a flourishing area of research with many applications. Context personalisation systems usually employ a user model to predict the appeal of the context to a particular user given a history of interactions. Most of the models used are context...

  10. Macro-players in stock markets

    CERN Document Server

    Röhner, B M

    2005-01-01

    It is usually assumed that stock prices reflect a balance between large numbers of small individual sellers and buyers. However, over the past fifty years mutual funds and other institutional shareholders have assumed an ever increasing part of stock transactions: their assets, as a percentage of GDP, have been multiplied by more than one hundred. The paper presents evidence which shows that reactions to major shocks are often dominated by a small number of institutional players. Most often the market gets a wrong perception and inadequate understanding of such events because the relevant information (e.g. the fact that one mutual fund has sold several million shares) only becomes available weeks or months after the event, through reports to the Securities and Exchange Commission (SEC). Our observations suggest that there is a radical difference between small ($ 5% $) price changes which, on the contrary, may be caused by massive sales (or purchases) by a few players. This suggests that the mechanisms which a...

  11. Evolutionary game theory: molecules as players.

    Science.gov (United States)

    Bohl, Katrin; Hummert, Sabine; Werner, Sarah; Basanta, David; Deutsch, Andreas; Schuster, Stefan; Theissen, Günter; Schroeter, Anja

    2014-12-01

    In this and an accompanying paper we review the use of game theoretical concepts in cell biology and molecular biology. This review focuses on the subcellular level by considering viruses, genes, and molecules as players. We discuss in which way catalytic RNA can be treated by game theory. Moreover, genes can compete for success in replication and can have different strategies in interactions with other genetic elements. Also transposable elements, or "jumping genes", can act as players because they usually bear different traits or strategies. Viruses compete in the case of co-infecting a host cell. Proteins interact in a game theoretical sense when forming heterodimers. Finally, we describe how the Shapley value can be applied to enzymes in metabolic pathways. We show that game theory can be successfully applied to describe and analyse scenarios at the molecular level resulting in counterintuitive conclusions.

  12. Player Transformation of Educational Multiplayer Games

    DEFF Research Database (Denmark)

    Magnussen, Rikke; Misfeldt, Morten

    2004-01-01

    are used for formal education. In this paper we argue that player transformation of educational games can, however, be the basis of exciting and unconventional learning of valuable things, such as how to transform information technology to better accommodate social interaction.......Children's great interest in multiplayer games has led to attempts to design educational multiplayer games. In this study, we have studied a test of an educational multiplayer game designed for mathematics education for children aged nine to twelve. In our observations, it became clear that pupils...... transformed the game to accommodate social interaction. With these transformed ways of playing the game, they managed to get to the top of the high score list while avoiding the educational parts of the game. Players transforming educational games to escape learning elements can be a problem when these games...

  13. Tibia and fibula fractures in soccer players.

    Science.gov (United States)

    Boden, B P; Lohnes, J H; Nunley, J A; Garrett, W E

    1999-01-01

    We performed a retrospective review of 31 athletes who sustained a fracture of the lower leg from a direct blow while playing soccer. Fifteen fractures involved both the tibia and fibula 11 only the tibia, and 5 only the fibula. Information was collected using a standardized questionnaire. The mean follow-up from the time of injury was 30 months. Injuries typically occurred in young, competitive athletes during game situations. The mechanisms were broadly classified into several categories: contact during a slide tackle (13, 42%), a collision with the goalkeeper (8, 26%), two opposing players colliding while swinging for a loose ball (7, 23%), or a player being kicked by a standing opponent (3, 10%). The majority of fractures (26, 90%) occurred while the athletes were wearing shin guards. The point of impact was with the shin guard prior to the fracture in 16 cases (62%). Return to competitive soccer averaged 40 weeks for combined tibia and fibula fractures, 35 weeks for isolated tibia fractures, and 18 weeks for isolated fibula fractures. Injuries were associated with a high incidence of major complications (12 out of 31, 39%), especially in concurrent tibia and fibula fractures (8 out of 15, 50%). These findings suggest that lower leg fractures in soccer players are serious injuries, often necessitating a prolonged recovery time. In addition, this study questions the ability of shin guards to protect against fractures.

  14. The El Dorado of Handball? Foreign Female Players Stay, while Domestic Players Return from Abroad.

    Science.gov (United States)

    Bon, Marta; Topič, Mojca Doupona; Šibila, Marko

    2016-04-01

    The main purpose of this research was to study the characteristics of migration in European women's handball based on the Slovenian example and to find the differences between the foreigners coming to Slovenia and the Slovenians transferring to foreign clubs. The research was based on 16 open face-to-face semi-structured interviews (8 Slovenians (age 29.5 ± 6.2 years) and 8 foreigners (age 35.5 ± 8.7 years)). We found out that the most powerful factor in foreigners was the financial one, while within Slovenian players it was their personal desire for progression within their sport, the club's reputation and poor conditions in their previous club. The results confirm that when making a decision on transfer, all players had the support of family and friends, while the clubs of foreign players were not as supportive. Most interviewees considered their careers successful and did not regret going abroad. The research indicates that the largest differences discovered between Slovenians and foreigners were that foreign female players chose to stay in the new country (Slovenia), while domestic players returned home after few years playing abroad. In conclusion, the results show that in top-level handball there are important differences between migration models which are based on nationality and also that the migration models change throughout time, which is largely connected with the socioeconomic events in the country of origin or transfer.

  15. LYMPHOCYTE APOPTOSIS IN PSORIASIS

    Directory of Open Access Journals (Sweden)

    О. M. Kapuler

    2006-01-01

    Full Text Available Abstract. Forty-two patients with progressive vulgar psoriasis (PASI = 19.7 ± 1.5 and 40 healthy volunteers were under investigation. Psoriatic patients were characterized by increased number of CD4+ CD95+ peripheral blood T lymphocytes, which correlates with clinical psoriatic score, and by increased levels of soluble Fas (sFas in serum, as compared to controls (resp., 1868.1 ± 186.8 pg/ml vs. 1281.4 ± 142.5 pg/ml, PLSD = 0.019. The levels of spontaneous lymphocyte apoptosis and anti-Fas (Mab-induced apoptosis in psoriatic patients did not differ from the controls. However, apoptosis induced by “oxidative stress” (50 M Н202, 4 hrs was depressed in the patients. Moreover, a simultaneous assessment of cell cycle structure (metachromatic staining with Acridine Orange, apoptosis and Fas receptor expression (AnnV-FITC/antiFas mAbs-PE staining following a short-term mitogenic stimulation (PHA-P, 5 µg/ml, 24 hrs were performed. We found no marked differences in mitogenic reactivity, activation-induced apoptosis, and activation-induced Fas receptor expression when studying lymphocytes from healthy donors and psoriatic patients. However, PHA-activated lymphocytes from psoriatic patients displayed a significantly decreased ratio of AnnV+CD95+ to the total AnnV+ subpopulation, thus suggesting a decreased role of Fas-dependent mechanisms of apoptosis during the cell activation. The data obtained confirm a view, that an abnormal lymphocyte “apoptotic reactivity”, which plays a crucial role in the mechanisms of autoimmunity, may also of importance in the pathogenesis of psoriasis.

  16. Apoptosis - Methods and Protocols

    Directory of Open Access Journals (Sweden)

    CarloAlberto Redi

    2010-03-01

    Full Text Available Apoptosis - Methods and ProtocolsSecond edition, 2009; Peter Erhardt and Ambrus Toth (Eds; Springer Protocols - Methods in molecular biology, vol. 559; Humana press, Totowa, New Jersey (USA; Pages: 400; €88.35; ISBN: 978-1-60327-016-8The editors rightly begin the preface telling us that: “The ability to detect and quantify apoptosis, to understand its biochemistry and to identify its regulatory genes and proteins is crucial to biomedical research”. Nowadays this is a grounding concept of biology and medicine. What is particularly remarkable...

  17. The biochemistry of apoptosis.

    Science.gov (United States)

    Hengartner, M O

    2000-10-12

    Apoptosis--the regulated destruction of a cell--is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme requires the coordinated activation and execution of multiple subprogrammes. Here I review the basic components of the death machinery, describe how they interact to regulate apoptosis in a coordinated manner, and discuss the main pathways that are used to activate cell death.

  18. Relations of Control: Walkthroughs and the Structuring of Player Agency

    Directory of Open Access Journals (Sweden)

    James Newman

    2010-07-01

    Full Text Available Videogame walkthroughs provide instructions on various elements of gameplay in relation to specific digital games, and exist as text-based documents and, to a lesser extent, as recorded moving image game footage. We focus here on written-walkthroughs for the purposes of depth, while recognising the specific and significant position that moving image walkthroughs hold (see Ashton, forthcoming. Player-produced walkthroughs, freely and widely distributed online, point to the broader social contexts that inform and structure player agency. In this article, we emphasize three perspectives on these documents. First, walkthroughs can be approached as a means of recording and codifying playing styles, thereby legitimising specific approaches or strategies. Accordingly, we highlight glitch hunting and the Pokémon series to illustrate the diversity of these playing styles and the significance of the walkthrough as a form of ludic archival document. Second, walkthroughs as textual codifications of gameplay potential can encourage new styles of engagement with authors and performers by outlining opportunities for play, and illuminating strategies and techniques previously unknown to the reader. Importantly, as we shall demonstrate, walkthroughs not only investigate and interrogate game texts – exploring their every narrative turn and spatial aspects in minute detail – but also frequently present techniques that take advantage of weaknesses and flaws in the ruleset or code of the game in order to offer new gameplay options. In this respect, as James Newman (2008 suggests, walkthroughs can be understood as a form of reverse-engineering that renegotiates the player-designer relationship and encourages (perhaps even demands deliberately investigative, resistant and deviant strategies of gameplay. These modes of engagement frequently involve playing beyond performative norms and technical limits. The walkthrough, then, is both a document of the game as

  19. Calpain Activator Dibucaine Induces Platelet Apoptosis

    Directory of Open Access Journals (Sweden)

    Jun Liu

    2011-03-01

    Full Text Available Calcium-dependent calpains are a family of cysteine proteases that have been demonstrated to play key roles in both platelet glycoprotein Ibα shedding and platelet activation and altered calpain activity is associated with thrombotic thrombocytopenic purpura. Calpain activators induce apoptosis in several types of nucleated cells. However, it is not clear whether calpain activators induce platelet apoptosis. Here we show that the calpain activator dibucaine induced several platelet apoptotic events including depolarization of the mitochondrial inner transmembrane potential, up-regulation of Bax and Bak, down-regulation of Bcl-2 and Bcl-XL, caspase-3 activation and phosphatidylserine exposure. Platelet apoptosis elicited by dibucaine was not affected by the broad spectrum metalloproteinase inhibitor GM6001. Furthermore, dibucaine did not induce platelet activation as detected by P-selectin expression and PAC-1 binding. However, platelet aggregation induced by ristocetin or α-thrombin, platelet adhesion and spreading on von Willebrand factor were significantly inhibited in platelets treated with dibucaine. Taken together, these data indicate that dibucaine induces platelet apoptosis and platelet dysfunction.

  20. Vascular Health in American Football Players: Cardiovascular Risk Increased in Division III Players

    Directory of Open Access Journals (Sweden)

    Deborah L. Feairheller

    2016-01-01

    Full Text Available Studies report that football players have high blood pressure (BP and increased cardiovascular risk. There are over 70,000 NCAA football players and 450 Division III schools sponsor football programs, yet limited research exists on vascular health of athletes. This study aimed to compare vascular and cardiovascular health measures between football players and nonathlete controls. Twenty-three athletes and 19 nonathletes participated. Vascular health measures included flow-mediated dilation (FMD and carotid artery intima-media thickness (IMT. Cardiovascular measures included clinic and 24 hr BP levels, body composition, VO2 max, and fasting glucose/cholesterol levels. Compared to controls, football players had a worse vascular and cardiovascular profile. Football players had thicker carotid artery IMT (0.49 ± 0.06 mm versus 0.46 ± 0.07 mm and larger brachial artery diameter during FMD (4.3±0.5 mm versus 3.7±0.6 mm, but no difference in percent FMD. Systolic BP was significantly higher in football players at all measurements: resting (128.2±6.4 mmHg versus 122.4±6.8 mmHg, submaximal exercise (150.4±18.8 mmHg versus 137.3±9.5 mmHg, maximal exercise (211.3±25.9 mmHg versus 191.4±19.2 mmHg, and 24-hour BP (124.9±6.3 mmHg versus 109.8±3.7 mmHg. Football players also had higher fasting glucose (91.6±6.5 mg/dL versus 86.6±5.8 mg/dL, lower HDL (36.5±11.2 mg/dL versus 47.1±14.8 mg/dL, and higher body fat percentage (29.2±7.9% versus 23.2±7.0%. Division III collegiate football players remain an understudied population and may be at increased cardiovascular risk.

  1. Exploring Game Performance in the National Basketball Association Using Player Tracking Data.

    Directory of Open Access Journals (Sweden)

    Jaime Sampaio

    Full Text Available Recent player tracking technology provides new information about basketball game performance. The aim of this study was to (i compare the game performances of all-star and non all-star basketball players from the National Basketball Association (NBA, and (ii describe the different basketball game performance profiles based on the different game roles. Archival data were obtained from all 2013-2014 regular season games (n = 1230. The variables analyzed included the points per game, minutes played and the game actions recorded by the player tracking system. To accomplish the first aim, the performance per minute of play was analyzed using a descriptive discriminant analysis to identify which variables best predict the all-star and non all-star playing categories. The all-star players showed slower velocities in defense and performed better in elbow touches, defensive rebounds, close touches, close points and pull-up points, possibly due to optimized attention processes that are key for perceiving the required appropriate environmental information. The second aim was addressed using a k-means cluster analysis, with the aim of creating maximal different performance profile groupings. Afterwards, a descriptive discriminant analysis identified which variables best predict the different playing clusters. The results identified different playing profile of performers, particularly related to the game roles of scoring, passing, defensive and all-round game behavior. Coaching staffs may apply this information to different players, while accounting for individual differences and functional variability, to optimize practice planning and, consequently, the game performances of individuals and teams.

  2. Exploring Game Performance in the National Basketball Association Using Player Tracking Data

    Science.gov (United States)

    Calleja-González, Julio; Jiménez Sáiz, Sergio; Schelling i del Alcázar, Xavi; Balciunas, Mindaugas

    2015-01-01

    Recent player tracking technology provides new information about basketball game performance. The aim of this study was to (i) compare the game performances of all-star and non all-star basketball players from the National Basketball Association (NBA), and (ii) describe the different basketball game performance profiles based on the different game roles. Archival data were obtained from all 2013-2014 regular season games (n = 1230). The variables analyzed included the points per game, minutes played and the game actions recorded by the player tracking system. To accomplish the first aim, the performance per minute of play was analyzed using a descriptive discriminant analysis to identify which variables best predict the all-star and non all-star playing categories. The all-star players showed slower velocities in defense and performed better in elbow touches, defensive rebounds, close touches, close points and pull-up points, possibly due to optimized attention processes that are key for perceiving the required appropriate environmental information. The second aim was addressed using a k-means cluster analysis, with the aim of creating maximal different performance profile groupings. Afterwards, a descriptive discriminant analysis identified which variables best predict the different playing clusters. The results identified different playing profile of performers, particularly related to the game roles of scoring, passing, defensive and all-round game behavior. Coaching staffs may apply this information to different players, while accounting for individual differences and functional variability, to optimize practice planning and, consequently, the game performances of individuals and teams. PMID:26171606

  3. Exploring Game Performance in the National Basketball Association Using Player Tracking Data.

    Science.gov (United States)

    Sampaio, Jaime; McGarry, Tim; Calleja-González, Julio; Jiménez Sáiz, Sergio; Schelling I Del Alcázar, Xavi; Balciunas, Mindaugas

    2015-01-01

    Recent player tracking technology provides new information about basketball game performance. The aim of this study was to (i) compare the game performances of all-star and non all-star basketball players from the National Basketball Association (NBA), and (ii) describe the different basketball game performance profiles based on the different game roles. Archival data were obtained from all 2013-2014 regular season games (n = 1230). The variables analyzed included the points per game, minutes played and the game actions recorded by the player tracking system. To accomplish the first aim, the performance per minute of play was analyzed using a descriptive discriminant analysis to identify which variables best predict the all-star and non all-star playing categories. The all-star players showed slower velocities in defense and performed better in elbow touches, defensive rebounds, close touches, close points and pull-up points, possibly due to optimized attention processes that are key for perceiving the required appropriate environmental information. The second aim was addressed using a k-means cluster analysis, with the aim of creating maximal different performance profile groupings. Afterwards, a descriptive discriminant analysis identified which variables best predict the different playing clusters. The results identified different playing profile of performers, particularly related to the game roles of scoring, passing, defensive and all-round game behavior. Coaching staffs may apply this information to different players, while accounting for individual differences and functional variability, to optimize practice planning and, consequently, the game performances of individuals and teams.

  4. Kinematic description of elite vs. Low level players in team-handball jump throw.

    Science.gov (United States)

    Wagner, Herbert; Buchecker, Michael; von Duvillard, Serge P; Müller, Erich

    2010-01-01

    The jump throw is the most applied throwing technique in team- handball (Wagner et al., 2008); however, a comprehensive analysis of 3D-kinematics of the team-handball jump throw is lacking. Therefore, the purpose of our study was: 1) to measure differences in ball release speed in team- handball jump throw and anthropometric parameters between groups of different levels of performance and (2) to analyze upper body 3D-kinematics (flexion/extension and rotation) to determine significant differences between these groups. Three-dimensional kinematic data was analyzed via the Vicon MX 13 motion capturing system (Vicon Peak, Oxford, UK) from 26 male team-handball players of different performance levels (mean age: 21.2 ± 5.0 years). The participants were instructed to throw the ball (IHF Size 3) onto a target at 8 m distance, and to hit the center of a square of 1 × 1 m at about eye level (1.75 m), with maximum ball release speed. Significant differences between elite vs. low level players were found in the ball release speed (p handball players who were taller and of greater body weight have the ability to achieve a higher ball release speed in the jump throw, and that an increase in trunk flexion and rotation angular velocity improve the performance in team-handball jump throw that should result in an increase of ball release speed. Key pointsTeam-handball players who were taller and of greater body weight have the ability to achieve a higher ball release speed.An increase in trunk flexion, trunk rotation and shoulder internal rotation angular velocity should result in an increase of ball release speed.Trunk movements are normally well observable for experienced coaches, easy correctable and therefore practical to improve the performance in team-handball jump throw of low level players during training without using complex measurement devices.

  5. Apoptosis and inflammation

    Directory of Open Access Journals (Sweden)

    C. Haanen

    1995-01-01

    Full Text Available During the last few decades it has been recognized that cell death is not the consequence of accidental injury, but is the expression of a cell suicide programme. Kerr et al. (1972 introduced the term apoptosis. This form of cell death is under the influence of hormones, growth factors and cytokines, which depending upon the receptors present on the target cells, may activate a genetically controlled cell elimination process. During apoptosis the cell membrane remains intact and the cell breaks into apoptotic bodies, which are phagocytosed. Apoptosis, in contrast to necrosis, is not harmful to the host and does not induce any inflammatory reaction. The principal event that leads to inflammatory disease is cell damage, induced by chemical/physical injury, anoxia or starvation. Cell damage means leakage of cell contents into the adjacent tissues, resulting in the capillary transmigration of granulocytes to the injured tissue. The accumulation of neutrophils and release of enzymes and oxygen radicals enhances the inflammatory reaction. Until now there has been little research into the factors controlling the accumulation and the tissue load of granulocytes and their histotoxic products in inflammatory processes. Neutrophil apoptosis may represent an important event in the control of intlamtnation. It has been assumed that granulocytes disintegrate to apoptotic bodies before their fragments are removed by local macrophages. Removal of neutrophils from the inflammatory site without release of granule contents is of paramount importance for cessation of inflammation. In conclusion, apoptotic cell death plays an important role in inflammatory processes and in the resolution of inflammatory reactions. The facts known at present should stimulate further research into the role of neutrophil, eosinophil and macrophage apoptosis in inflammatory diseases.

  6. Using physiological measures in conjunction with other UX approaches for better understanding of the player's gameplay experiences

    CERN Document Server

    Mirza-Babaei, Pejman

    2011-01-01

    The goal of video games is to challenge and entertain the players. Successful video games deliver experience that impact players on a level of arousal. Therefore undertaking a user experience (UX) study is crucial to ensure that a game achieves both critical and financial success. However, traditional usability methods (observation, subjective reporting, questionnaire, and interview) have a number of limitations on game user research. In this study we capture player's physiological measures during a gameplay session, to indicate micro-events that have caused changes in their body signals. At the post-gameplay interviews we ask participants to comment and describe their feelings on the selected events. The aim of this study is not to over-interpret physiological measures, but on using blips in measures to help identify key points in a game, which we then use to investigate further with the participant. This approach provides a method that can identify not only the negative user experience and usability issues ...

  7. Team Commitment as a Mediator Between Self-Esteem and Team Climate as Perceived by Korean Youth Soccer Players.

    Science.gov (United States)

    Jung, Myungjin; Kang, Sangwook; Kwon, Sungho

    2016-06-01

    This study examined whether team commitment mediates the relationship between self-esteem and perceived team climate in Korean youth soccer players. A total of 366 youth soccer players from the Korea football association participated in this study. Self-esteem and team commitment were found to significantly and positively affect perceived team climate; team commitment more strongly affected perceived team climate. Regarding structural relationships, self-esteem's direct effect on perceived team climate was not significant; however, self-esteem's indirect effect through team commitment was significant. Team commitment therefore mediated the relationship between self-esteem and perceived team climate. Metric invariance was supported for groups categorized by grade and key player, confirming that the model could be applied to various groups.

  8. Temperamental Predictive Factors for Success in Korean Professional Baseball Players

    OpenAIRE

    Kang, Kyoung Doo; Han, Doug Hyun; Hannon, James C.; Hall, Morgan S.; Choi, Jae Won

    2015-01-01

    Objective In this five-year cohort study, we hypothesize that factors of temperament and character in professional baseball players predict the speed of obtaining success and the quality of success as well as anxiety control. Methods Participants included 120 male rookie players from the Korea Baseball Organization (KBO) and 107 male non-players with no history of playing baseball. The personality/characters and state/trait anxieties of participants were assessed with the Temperament and Char...

  9. Heart rate and activity profile for young female soccer players

    OpenAIRE

    2008-01-01

    The physical and physiological demands of high-level male soccer have been studied extensively, while few studies have investigated the demands placed on females during match-play, however, there is no information available about the heart rate and activity profile of young female soccer players during match play. Therefore, the aim of this study was to examine cardiovascular (heart-rates HR) and physical demands of young female soccer players during a match. Players were observed during a fr...

  10. Nutritional Habits & Knowledge in the Division I Collegiate Football Player

    OpenAIRE

    Hale, Mallory

    2013-01-01

    Objectives: Athlete’s nutritional habits and knowledge can directly affect their performance. The purpose of this study is to investigate the nutritional habits and knowledge of the Division I collegiate football player. Methods: The participants of this study are male Division I college football players at Utah State University. The athletes included 45 players ranging from 18-26 and include freshman through seniors. Results: Over eighty six percent of the athletes were unaware that a ...

  11. Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis

    Directory of Open Access Journals (Sweden)

    Stéphane Chabaud

    2011-01-01

    Full Text Available Diffuse systemic sclerosis (SSc is a fatal autoimmune disease characterized by an excessive ECM deposition inducing a loss of function of skin and internal organs. Apoptosis is a key mechanism involved in all the stages of the disease: vascular damage, immune dysfunction, and fibrosis. The purpose of this paper is to gather new findings in apoptosis related to SSc, to highlight relations between apoptosis and fibrosis, and to identify new therapeutic targets.

  12. Executive functions predict the success of top-soccer players.

    Directory of Open Access Journals (Sweden)

    Torbjörn Vestberg

    Full Text Available While the importance of physical abilities and motor coordination is non-contested in sport, more focus has recently been turned toward cognitive processes important for different sports. However, this line of studies has often investigated sport-specific cognitive traits, while few studies have focused on general cognitive traits. We explored if measures of general executive functions can predict the success of a soccer player. The present study used standardized neuropsychological assessment tools assessing players' general executive functions including on-line multi-processing such as creativity, response inhibition, and cognitive flexibility. In a first cross-sectional part of the study we compared the results between High Division players (HD, Lower Division players (LD and a standardized norm group. The result shows that both HD and LD players had significantly better measures of executive functions in comparison to the norm group for both men and women. Moreover, the HD players outperformed the LD players in these tests. In the second prospective part of the study, a partial correlation test showed a significant correlation between the result from the executive test and the numbers of goals and assists the players had scored two seasons later. The results from this study strongly suggest that results in cognitive function tests predict the success of ball sport players.

  13. Towards Player Adaptivity in a Serious Game for Conflict Resolution

    DEFF Research Database (Denmark)

    Grappiolo, C.; Cheong, Yun-Gyung; Togelius, J.

    2011-01-01

    to resolve this type of conflict, the underlying system generates level content automatically which adapts to player experience and behaviour. Preliminary results demonstrate the efficiency of the procedural content generation mechanism in guiding the training of players towards targeted learning objectives.......We present a technology demonstrator for an adaptive serious game for teaching conflict resolution and discuss the research questions associated with the project. The prototype is a single-player 3D mini-game which simulates a resource management conflict scenario. In order to teach the player how...

  14. Arthroscopic Shoulder Surgery in Female Professional Tennis Players

    Science.gov (United States)

    Young, Simon W.; Safran, Marc R.; Dakic, Jodie; Nguyen, Michael L.; Stroia, Kathleen

    2013-01-01

    Objectives: Recent publications have highlighted the relatively poor outcome of other overhead athletes, particularly baseball players, with regard to return to sports at the same or higher level after shoulder surgery. However, true assessment of their ability when returning to sport is not as clear. Further, ability to return to other overhead sports has not been reported. Our objective was to assess outcome and time to return to previous level of function following shoulder surgery in professional tennis players. Methods: The records of all female tennis players on the Women’s Tennis Association (WTA) professional circuit between January 2008 and June 2010 were reviewed to identify players who underwent shoulder surgery on their dominant (serving) shoulder. Details of the surgery including date, procedures performed, and complications were recorded. The primary outcomes were ability and time to return to professional play, and if they were able to return to their previous level of function, as determined by singles ranking. Pre and post-operative singles rankings were used to determine rate and completeness of return to preoperative function. Their highest ranking pre-injury, post operatively, and the time to return to pre-injury ranking were evaluated. Results: During the study period eight professional women tennis players from the WTA underwent shoulder surgery on their dominant arm. All surgery was performed arthroscopically, 7 out of 8 players had more than one procedure performed during the surgery. In total, 3 players underwent debridement of a partial rotator cuff tear and 2 players underwent repair of a complete supraspinatus tear. Three players had an anterior labral repair or reconstruction for anterior instability, and one player underwent repair of a SLAP lesion. Two players underwent neurolysis of a suprascapular nerve, and three players in total underwent a subacromial decompression. All players (100%) returned to professional play. The mean

  15. A Multi-agent player for Settlers of Catan

    OpenAIRE

    2008-01-01

    There are many games that have been a challenge to Research in Artificial Intelligence. One such game is Settlers of Catan (SoC). The purpose of this thesis is to develop a Multi-agent player for SoC. Although it is difficult to focus on all the dimensions of the game during implementation, therefore a good enough solution is proposed. An emphasis is placed on building a good trader for the player. Once a working solution had been built, the player was tested against other players which inclu...

  16. Membongkar Veto Player dalam Politik Kepartaian Indonesia Menuju Pemilu 2014

    Directory of Open Access Journals (Sweden)

    Arya Budi

    2014-05-01

    Full Text Available The article explains about how party elites, then identified as veto players, in Indonesia’s 2014 election organize themselve into party organization. The authority institutionalization of the veto player creates a decisional and positional quadrant of each party in terms of party politics of 2014 election. The findings of veto player pattern in such a party politics confirm forms of a centripetal force of politics in party organization. Finally, veto player behavior causes a spectrum of political cybernetics among political parties based on its turbulence, cohesiveness, and switching elites.

  17. Player Collaboration in the Explorative Sound Environment ToneInk

    DEFF Research Database (Denmark)

    Hansen, Anne-Marie S.; Andersen, Hans Jørgen; Raudaskoski, Pirkko Liisa

    2016-01-01

    In the present paper, ToneInk, a prototype of a music based play scenario that investigates player collaboration, is introduced. ToneInk is an explorative sound environment that differs from the majority of music based games in that players can collaborate and be creative in the way they express...... mutual awareness, and in general were more passive when they needed to monitor a screen interface that supported the sound environment. Player collaboration was strongest when players negotiated rhythm, while the negotiation of melody was temporally offset and consisted of long individual explorations....

  18. Isolated and painless (? atrophy of the infraspinatus muscle: left handed versus right handed volleyball players

    Directory of Open Access Journals (Sweden)

    Thiago D. Gonçalves Côelho

    1994-12-01

    Full Text Available The suprascapular nerve originates from the upper trunk of the brachial plexus or less frequently from the root of C5. It runs a short way and crosses the suprascapular notch. It innervates the supraspinatus muscle and the acromioclavicular and glenohumeral joints. Then, it crosses the lateral edge of the spine of the scapula passing through the spinoglenoid notch, and innervates the infraspinatus muscle. These are potential sites of injury to the suprascapular nerve. Three cases of suprascapular nerve entrapment causing an isolated infraspinatus muscle atrophy in volleyball players were studied. It is suggested the hypothesis that the nature of the smash, in which the athlete uses the arm violently, more than does in volleyball service or in the art of reception, is the key to the pathogenesis of the lesion in volleyball players.

  19. Extortion subdues human players but is finally punished in the prisoner's dilemma.

    Science.gov (United States)

    Hilbe, Christian; Röhl, Torsten; Milinski, Manfred

    2014-05-29

    Extortion is the practice of obtaining advantages through explicit forces and threats. Recently, it was demonstrated that even the repeated prisoner's dilemma, one of the key models to explain mutual cooperation, allows for implicit forms of extortion. According to the theory, extortioners demand and receive an excessive share of any surplus, which allows them to outperform any adapting co-player. To explore the performance of such strategies against humans, we have designed an economic experiment in which participants were matched either with an extortioner or with a generous co-player. Although extortioners succeeded against each of their human opponents, extortion resulted in lower payoffs than generosity. Human subjects showed a strong concern for fairness: they punished extortion by refusing to fully cooperate, thereby reducing their own, and even more so, the extortioner's gains. Thus, the prospects of extorting others in social relationships seem limited; in the long run, generosity is more profitable.

  20. A new game plan for C players.

    Science.gov (United States)

    Axelrod, Beth; Handfield-Jones, Helen; Michaels, Ed

    2002-01-01

    It's a big driver of business success, but one that executives are loath to talk about: upgrading the talent pool by weeding out "C" players from management. These aren't the incompetent or unethical managers whom organizations dismiss without a backward glance; C performers deliver results that are acceptable--barely--but they fail to innovate or to inspire the people they lead. The authors of The War for Talent have studied what it takes to upgrade an organization's talent pool. In this article, they explore the hidden costs of tolerating under-performance and acknowledge the reasons why executives may shy away from dealing decisively with C players. They recommend that organizations take an "iron hand in a velvet glove" approach to managing subpar performers. That is, companies should establish rigorous, disciplined processes for assessing and dealing with low-performing managers but still treat them with respect. The authors outline three ironhanded steps. First, executives must identify C players by evaluating their talents and distributing employee performances along an assessment curve. Second, executives must agree on explicit action plans that articulate the improvements or changes that C performers must achieve within six to 12 months. And third, executives should hold managers accountable for carrying out the action plans. Without such discipline, procrastination, rationalization, and inaction will prevail. The authors also emphasize the need for the "velvet glove." Executives must ensure that low performers are treated with dignity, so they should offer candid feedback, instructive coaching, and generous severance packages and outplacement support. The authors' approach isn't about being tough on people; it's about being relentlessly focused on performance.

  1. Meniscal ossicle in a professional soccer player.

    Science.gov (United States)

    Ogassawara, R; Zayni, R; Orhant, E; Noel, E; Fournier, Y; Hager, J-P; Chambat, P; Sonnery-Cottet, B

    2011-06-01

    Meniscal ossicles are an unusual finding and a rare cause for knee pain. They are often initially diagnosed as a loose body, chondrocalcinosis or meniscal calcification within the knee joint. Few cases have been reported in the literature. We present a case of a meniscal ossicle with an associated femoral cartilage lesion in a healthy 26-year-old male professional soccer player who presented with swelling and pain. The purpose of this article is to discuss the origins, radiological features, clinical symptoms and prognosis of meniscal ossicles.

  2. Acing common skin problems in tennis players.

    Science.gov (United States)

    Basler, R S; Garcia, M A

    1998-12-01

    The following measures can help prevent skin disorders in tennis players: wearing properly fitted shoes to avoid tennis toe, talon noir, and calluses; applying lubricants to protect against blisters and chafing; washing skin thoroughly to reduce the risk of acne mechanica; and wearing a hat and sunscreen to guard against photoinjury. 'Stringer's fingers' can be prevented by breaking the habit of adjusting the racket strings after each point. Should these disorders become troublesome, conservative treatments are usually effective. For example, calluses may be carefully pared, and pain from a subungual hemorrhage can be relieved by piercing the toenail with a hot paper clip.

  3. Payoff Shares in Two-Player Contests

    Directory of Open Access Journals (Sweden)

    Samuel Häfner

    2016-09-01

    Full Text Available In imperfectly discriminating contests with symmetric valuations, equilibrium payoffs are positive shares of the value of the prize. In contrast to a bargaining situation, players’ shares sum to less than one because a residual share of the value is lost due to rent dissipation. In this paper, we consider contests with two players and investigate the relationship between these equilibrium shares and the parameters of a class of asymmetric Tullock contest success functions. Our main finding is that any players’ shares that sum up to less than one can arise as the unique outcome of a pure-strategy Nash equilibrium for appropriate parameters.

  4. Probabilistic one-player Ramsey games via deterministic two-player games

    CERN Document Server

    Belfrage, Michael; Spöhel, Reto

    2009-01-01

    Consider the following probabilistic one-player game: The board is a graph with $n$ vertices, which initially contains no edges. In each step, a new edge is drawn uniformly at random from all non-edges and is presented to the player, henceforth called Painter. Painter must assign one of $r$ available colors to each edge immediately, where $r \\geq 2$ is a fixed integer. The game is over as soon as a monochromatic copy of some fixed graph $F$ has been created, and Painter's goal is to 'survive' for as many steps as possible before this happens. We present a new technique for deriving upper bounds on the threshold of this game, i.e., on the typical number of steps Painter will survive with an optimal strategy. More specifically, we consider a deterministic two-player variant of the game where the edges are not chosen randomly, but by a second player Builder. However, Builder has to adhere to the restriction that, for some real number $d$, the ratio of edges to vertices in all subgraphs of the evolving board neve...

  5. MODERN TECHNOLOGIES AND APPROACHES TO APOPTOSIS STUDIES IN EXPERIMENTAL BIOLOGY

    Directory of Open Access Journals (Sweden)

    I. V. Kudriavtsev

    2012-01-01

    Full Text Available Abstract. This review is focused on analysis of currently used flow cytometric methods designed foridentifying apoptotic cells in various invertebrate and vertebrate species. Apoptosis can be characterized by stage-specific morphological and biochemical changes that are typical to all kinds of eukaryotic cells. In this article, we consider different techniques of apoptosis detection based on assessment of cellular morphology and plasma membrane alterations, activation of intracellular enzymes and components of a caspase cascade, as well as DNA fragmentation and failure of mitochondrial transmembrane potential, as assessed in various animal groups. Apoptosis recognized as a key mechanism aiming at maintenance of cellular homeostasis in multicellular organisms, and such investigations represent a necessary component of fundamental and applied studies in diverse fields of experimental biology and immunology. A broad spectrum of apoptosis markers isused, and the preference is given to optimal approaches, as determined by experimental tasks, and technical opportunities of the laboratory.

  6. Apoptosis and the target genes of microRNA-21

    Institute of Scientific and Technical Information of China (English)

    Lindsey E. Becker Buscaglia; Yong Li

    2011-01-01

    MicroRNA-21 (miR-21) is frequently up-regulated in cancer and the majodty of its reported targets are tumor suppressors. Through functional suppression, miR-21 is implicated in practically every walk of oncogenic life: the promotion of cell proliferation, invasion and metastasis, genome instability and mutation, inflammation, replicative immortalization, abnormal metabolism, angiogenesis, and evading apoptosis, immune destruction, and growth suppressors. In particular, miR-21 is strongly involved in apoptosis. In this article, we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular apoptosis. This suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21.

  7. Fullerene and apoptosis

    Directory of Open Access Journals (Sweden)

    M. A. Orlova

    2014-07-01

    Full Text Available Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to practical medical use of them. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance to further promoting of either cytoprotective or cytotoxic effects. This lecture provides modern concept analysis regarding fullerenes effects on apoptosis pathway in normal and tumor cells.

  8. Fullerene and apoptosis

    Directory of Open Access Journals (Sweden)

    M. A. Orlova

    2013-01-01

    Full Text Available Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to practical medical use of them. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance to further promoting of either cytoprotective or cytotoxic effects. This lecture provides modern concept analysis regarding fullerenes effects on apoptosis pathway in normal and tumor cells.

  9. Apoptosis and survival

    Directory of Open Access Journals (Sweden)

    Manjul Tiwari

    2011-01-01

    Full Text Available The term apoptosis first appeared in the biomedical literature in 1972, to delineate a structurally distinctive mode of cell death responsible for cell loss within living tissues. The cardinal morphological features are cell shrinkage, accompanied by transient but violent bubbling and blebbing from the surface, and culminating in separation of the cell into a cluster of membrane-bounded bodies. Changes in several cell surface molecules also ensure that, in tissues, apoptotic cells are immediately recognised and phagocytosed by their neighbours. However, it is important to note that apoptosis is only one form of cell death and the particular death pathway that is the most important determinant for cancer therapy is not necessarily that which has the fastest kinetics, as is the bias in many laboratories, but rather that which displays the most sensitive dose-response relationship.

  10. Apoptosis: una muerte silenciosa

    Directory of Open Access Journals (Sweden)

    Isis Casadelvalle Pérez

    2006-01-01

    Full Text Available La apoptosis o muerte celular programada es un tipo de muerte presente en todas las células eucarióticas. Es un proceso ordenado y esencial del desarrollo normal y de mantenimiento de la homeostasis de un organismo. En el presente trabajo se resumen las principales características fisiológicas, bioquímicas y moleculares de la muerte por apoptosis, evento que ocurre de forma apagada o silenciosa, o sea, sin daño celular aparente diferenciándose claramente del proceso de necrosis celular. En ese proceso se destaca la mitocondria, como organelo celular donde mediado por la activación de las caspasas se inicia el paso hacia la muerte celular programada. En el momento actual, la apoptosis ha cobrado un verdadero valor para la mejor comprensión de los procesos biológicos normales en los que este evento está involucrado y que con anterioridad no era tomado en cuenta. En este sentido, se comentan las principales técnicas de detección de muerte celular programada y se aclara que la elección de algunas de ellas depende del modelo de estudio. Tambi én se dan a conocer algunas de las patologías generales en las que este proceso representa un papel determinante y se discute acerca de cómo algunas alteraciones en los mecanismos de regulación de la apoptosis inducen la aparici ón de varias enfermedades, incluyendo aquellos desórdenes en los que ocurre acumulación celular (cáncer, alteración cardiaca, neurodegeneración y SIDA. El estudio y caracterización de este complejo mecanismo ha cambiado profundamente la comprensión de numerosas patologías en los organismos eucariotas.

  11. Sex-specific differences in injury types among basketball players

    Directory of Open Access Journals (Sweden)

    Ito E

    2014-12-01

    Full Text Available Eri Ito, Jun Iwamoto, Koichiro Azuma, Hideo MatsumotoInstitute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, JapanAbstract: The purpose of the present study was to investigate sex-specific differences in injury types among basketball players. According to our database, during the 20-year period between October 1991 and June 2011, 1,219 basketball players (640 males and 579 females consulted our sports medicine clinic; in total, 1,414 injuries in basketball players (729 injuries in males and 685 injuries in females were recorded. The mean age of patients was 19.6 years. The most common injury site was the knee, followed by the foot and ankle, lower back, and upper extremities. There was a higher proportion of female players presenting with a knee injury, compared with male players (50.4% vs 41.7%, and a lower proportion of female players presenting with an upper extremity injury (5.1% vs 9.7%. The proportion of anterior cruciate ligament injury in the 10–19-year-old age group was higher among female players than among male players (45.9% vs 22.1%, while the proportions of Osgood–Schlatter disease in the 10–19-year-old age group and jumper's knee (patellar and femoral tendinopathy in the 20–29-year-old age group were higher among male players than among female players (12.5% vs 1.8% and 14.6% vs 3.7%, respectively. However, the proportions of other injuries did not differ significantly between male and female players. The present observational study, which was performed using a retrospective case-series design, showed the existence of sex-specific differences in knee injuries sustained while participating in basketball.Keywords: sports injury, sex, anterior cruciate ligament injury, Osgood–Schlatter disease, basketball

  12. Match analysis and player characteristics in rugby sevens.

    Science.gov (United States)

    Ross, Alex; Gill, Nicholas; Cronin, John

    2014-03-01

    Rugby sevens is a contact sport contested by two teams of seven players who compete over two 7-min halves, most frequently played in a tournament style. The IRB Sevens World Series is thought of as the preeminent rugby sevens competition in the world and has grown in competitiveness from its inception in 2000. The decision to include rugby sevens in the 2016 Olympics is likely to increase the global profile and participation in the game. Many rugby sevens players concurrently compete in 15-a-side rugby union as backs and loose forwards; however, a continued increase in the popularity of rugby sevens will likely see the emergence of the specialist rugby sevens player. Often thought of as the abbreviated version of rugby union, rugby sevens is played under nearly identical laws and on the same field dimensions as the 15-man code. However, research has shown the movement demands of rugby sevens and rugby union are dissimilar, with rugby sevens players spending a larger proportion of the game running at high intensity (≥ 5 m s(-1)). Given the dissimilarity in match demands in conjunction with differences in the competition structure between the codes, it appears the considerable depth of literature specific to performance in rugby union may be of little value for the preparation of rugby sevens players. Investigations of the physical characteristics of rugby sevens players show backs are lighter and shorter than forwards, while players across all positions possess a lean body composition. International rugby sevens players have similar speed characteristics to rugby union backs across distances of 10-30 m; however, rugby sevens players appear to have superior intermittent aerobic endurance. Despite being of likely importance, little is known of the strength and power characteristics of rugby sevens players. Research into the speed and aerobic endurance characteristics of rugby sevens players has not distinguished between backs and forwards and, as such, it is unclear

  13. Sport commitment in adolescent soccer players

    Directory of Open Access Journals (Sweden)

    Noelia Belando Pedreño

    2016-03-01

    Full Text Available The aim of this study was to contribute to the postulates of the self-determination theory, the hierarchical model of intrinsic and extrinsic motivation by Vallerand, and social goals. A structural regression model was estimated to analyze the relations between social goals (responsibility and relationships, praise for autonomous behavior, satisfaction of the basic psychological needs and intrinsic motivation in commitment to sport. A sample of 264 young Spanish soccer players aged between 14 and 16 (M =14.74, SD =.77 participated in the study. Structural Equation Modeling results showed that the social responsibility goal, the social relationship goal and praise for autonomous behavior predicted perceived competence. Furthermore, the relationship goal also predicted the need for relatedness. Satisfaction of the basic psychological needs for competence and relatedness predicted intrinsic motivation. Intrinsic motivation positively predicted future commitment to sport. These results highlighted the importance of social goals, praise for autonomous behavior and psychological mediators in encouraging greater commitment in young soccer players. Future research should focus on the coach’s role in generating greater commitment to sport through the development of intervention methodologies based on social goals.

  14. Scapula Kinematics of Youth Baseball Players.

    Science.gov (United States)

    Oliver, Gretchen; Weimar, Wendi

    2015-12-22

    Literature has revealed the importance of quantifying resting scapular posture in overhead athletes as well as quantifying scapular kinematics during dynamic movement. Prior to this project much of the attention in throwing research had been focused on the position of the humerus without description of the positioning of the scapula. Therefore, it was the purpose of this study to present scapular kinematics during pitching in youth baseball players. Twenty-five youth baseball players (age 11.3 + 1.0 years; body height 152.4 + 9.0 cm; body mass 47.5 + 11.3 kg), with no history of injury, participated in the study. Scapular kinematics at the events of maximum humeral external rotation (MER) and maximum humeral internal rotation (MIR) during the pitching motion were assessed three-dimensionally while pitching fastballs for strikes. Results revealed that at the event of MER, the scapula was in a position of retraction, upward rotation and a posterior tilt. While at the event of MIR, the scapula was protracted, upward rotated and tilted anteriorly.

  15. Scapula Kinematics of Youth Baseball Players

    Directory of Open Access Journals (Sweden)

    Oliver Gretchen

    2015-12-01

    Full Text Available Literature has revealed the importance of quantifying resting scapular posture in overhead athletes as well as quantifying scapular kinematics during dynamic movement. Prior to this project much of the attention in throwing research had been focused on the position of the humerus without description of the positioning of the scapula. Therefore, it was the purpose of this study to present scapular kinematics during pitching in youth baseball players. Twenty-five youth baseball players (age 11.3 + 1.0 years; body height 152.4 + 9.0 cm; body mass 47.5 + 11.3 kg, with no history of injury, participated in the study. Scapular kinematics at the events of maximum humeral external rotation (MER and maximum humeral internal rotation (MIR during the pitching motion were assessed three-dimensionally while pitching fastballs for strikes. Results revealed that at the event of MER, the scapula was in a position of retraction, upward rotation and a posterior tilt. While at the event of MIR, the scapula was protracted, upward rotated and tilted anteriorly.

  16. Player Collaboration in the Explorative Sound Environment ToneInk

    DEFF Research Database (Denmark)

    Hansen, Anne-Marie; Andersen, Hans Jørgen; Raudaskoski, Pirkko Liisa

    2016-01-01

    mutual awareness, and in general were more passive when they needed to monitor a screen interface that supported the sound environment. Player collaboration was strongest when players negotiated rhythm, while the negotiation of melody was temporally offset and consisted of long individual explorations....

  17. Relative risk for concussions in young female soccer players.

    Science.gov (United States)

    Strand, Sarah; Lechuga, David; Zachariah, Thomas; Beaulieu, Kathryn

    2015-01-01

    The objective of this study was to determine the relative risk and reported symptoms of concussions in 11- to 13-year-old, female soccer players. For this, a survey to compare the reported incidence of concussion in age-matched female soccer players to nonsoccer players was performed. The survey included 342 girls between the ages of 11 and 13: 195 were involved in an organized soccer team and 147 were not involved in organized soccer but were allowed to participate in any other sport or activity. A total of 94 of the 195 soccer players, or 48%, reported at least one symptom consistent with a concussion. The most prevalent symptom for these girls was headache (84%). A total of 34 of the 147 nonsoccer players, or 23%, reported at least one symptom consistent with a concussion in the previous six months. These results determined that the relative risk of probable concussions among 11- to 13-year-old, female soccer players is 2.09 (p soccer players is significantly higher than in a control group of nonsoccer players of the same sex and age.

  18. The Mental Skills Training of University Soccer Players

    Science.gov (United States)

    Sadeghi, Hassan; Omar-Fauzee, Mohd-Sofian; Jamalis, Marjohan; Ab-Latif, Rozita; Cheric, Majid Chahrdah

    2010-01-01

    The purpose of this study is to identify the kind of mental skills training needed most by the university soccer players. Eight male university football players (aged 25 to 36) from one large university in Kuala Lumpur agreed to participate in this study. On average, they have 10 years of playing experience. All of them have signed the informed…

  19. Differences in Soccer Kick Kinematics between Blind Players and Controls

    Science.gov (United States)

    Giagazoglou, Paraskevi; Katis, Athanasios; Kellis, Eleftherios; Natsikas, Christos

    2011-01-01

    The purpose of the current study was to examine the kinematic differences during instep soccer kicks between players who were blind and sighted controls. Eleven male soccer players who were blind and nine male sighted performed instep kicks under static and dynamic conditions. The results indicated significantly higher (p less than 0.05) ball…

  20. Gender Differences in Coping among Elite Table Tennis Players

    Science.gov (United States)

    Kirimoglu, Huseyin

    2011-01-01

    The current study aims to investigate the explanatory power of social support and coping in relation to a competitive sport event between male and female table tennis players. 246 university students table tennis players (120 men and 126 women) from different region and part of Turkey were invited to participate in a survey study included the…

  1. Translucent Players: Explaining Cooperative Behavior in Social Dilemmas

    Directory of Open Access Journals (Sweden)

    Valerio Capraro

    2016-06-01

    Full Text Available In the last few decades, numerous experiments have shown that humans do not always behave so as to maximize their material payoff. Cooperative behavior when non-cooperation is a dominant strategy (with respect to the material payoffs is particularly puzzling. Here we propose a novel approach to explain cooperation, assuming what Halpern and Pass call translucent players. Typically, players are assumed to be opaque, in the sense that a deviation by one player in a normal-form game does not affect the strategies used by other players. But a player may believe that if he switches from one strategy to another, the fact that he chooses to switch may be visible to the other players. For example, if he chooses to defect in Prisoner's Dilemma, the other player may sense his guilt. We show that by assuming translucent players, we can recover many of the regularities observed in human behavior in well-studied games such as Prisoner's Dilemma, Traveler's Dilemma, Bertrand Competition, and the Public Goods game.

  2. Labor Market Structure and Salary Determination among Professional Basketball Players.

    Science.gov (United States)

    Wallace, Michael

    1988-01-01

    The author investigates the labor market structure and determinants of salaries for professional basketball players. An expanded version of the resource perspective is used. A three-tiered model of labor market segmentation is revealed for professional basketball players, but other variables also are important in salary determination. (Author/CH)

  3. Differences in energy capacities between tennis players and runners.

    Science.gov (United States)

    Novak, Dario; Vucetić, Vlatko; Zugaj, Sanja

    2013-05-01

    The primary purpose of this study was to determine differences between elite athletes and tennis players in order to provide a clearer picture regarding the energy demands in modern tennis. Forty-eight (48) athletes and 24 tennis players from Croatian national leagues were compared in morphological and physiological parameters of an all-out incremental treadmill test with gas exchange measurements. Tennis players' HRmax (192.96+/-7.75 bpm) shows values that are most different to 400-meters sprinters (200.13+/-6.95 bpm). Maximum running speed of tennis players on the treadmill (vmax) is no different with the speed achieved by sprinters, while there are significant differences among other athletes. Values in running speed at anaerobic threshold (vAnT) show no statistically significant difference with the values for athlete sprinters and 400-m sprinters. Values of RvO2max for tennis players indicate significant similarities with athlete sprinters and 400-m sprinters while the values of RvO2AnT are nearly identical with the values for sprinters and show no statistically significant differences (ptennis players approximate most different those of the middle and long distance runners. This singles out the possible importance of the anaerobic capacity and the high level of sprint endurance in tennis players. Knowing these characteristics is the basis for planning and implementing training systems that will enable the increase and optimal usage of energy capacities of tennis players in possibly improving sports results.

  4. Development of repeated sprint ability in talented youth basketball players.

    NARCIS (Netherlands)

    Wierike, S.C. te; Jong, M.C. de; Tromp, E.J.; Vuijk, P.J.; Lemmink, K.A.; Malina, R.M.; Elferink-Gemser, M.T.; Visscher, C.

    2013-01-01

    Factors affecting repeated sprint ability (RSA) were evaluated in a mixed-longitudinal sample of 48 elite basketball players 14 to 19 years of age (16.1±1.7 years). Players were observed on six occasions during the 2008-2009 and 2009-2010 seasons. Three basketball-specific field tests were administe

  5. "Killing the Blues": a role for cellular suicide (apoptosis) in depression and the antidepressant response?

    Science.gov (United States)

    McKernan, Declan P; Dinan, Timothy G; Cryan, John F

    2009-08-01

    Apoptosis or programmed cell death is a critical regulator of tissue homeostasis and emerging evidence is focused on the role of apoptosis mechanisms in the central nervous system. Generally, apoptosis is necessary to prevent cancerous growths. However, excessive apoptosis in post-mitotic cells such as neurons leads to neurodegeneration. Chronic stress, which can precipitate depression, has been shown to increase the susceptibility of certain populations of neurons to cell death while antidepressant treatment, in general, shows the ability to oppose these effects and promote neuroprotection. Here, we discuss the major players in cell death pathways, the physiological implications of chronic stress and depression, chronic stress models in animals which result in cell death and the different classes of antidepressants and mood stabilizers that have been shown to prevent cell death. We discuss the cellular effects of antidepressants and possible modes of action in preventing apoptosis. Investigations on the role of apoptosis in mediating the molecular, physiological and behavioural effects of antidepressants may help gain a better mechanistic insight into drug action and allow refinement of current therapeutics in order to target these pathways in a specific manner.

  6. Identification of low Ca(2+) stress-induced embryo apoptosis response genes in Arachis hypogaea by SSH-associated library lift (SSHaLL).

    Science.gov (United States)

    Chen, Hua; Zhang, Chong; Cai, Tie Cheng; Deng, Ye; Zhou, Shuangbiao; Zheng, Yixiong; Ma, Shiwei; Tang, Ronghua; Varshney, Rajeev K; Zhuang, Weijian

    2016-02-01

    Calcium is a universal signal in the regulation of wide aspects in biology, but few are known about the function of calcium in the control of early embryo development. Ca(2+) deficiency in soil induces early embryo abortion in peanut, producing empty pods, which is a general problem; however, the underlying mechanism remains unclear. In this study, embryo abortion was characterized to be caused by apoptosis marked with cell wall degradation. Using a method of SSH cDNA libraries associated with library lift (SSHaLL), 62 differentially expressed genes were isolated from young peanut embryos. These genes were classified to be stress responses, catabolic process, carbohydrate and lipid metabolism, embryo morphogenesis, regulation, etc. The cell retardation with cell wall degradation was caused by up-regulated cell wall hydrolases and down-regulated cellular synthases genes. HsfA4a, which was characterized to be important to embryo development, was significantly down-regulated under Ca(2+) -deficient conditions from 15 days after pegging (DAP) to 30 DAP. Two AhCYP707A4 genes, encoding abscisic acid (ABA) 8'-hydroxylases, key enzymes for ABA catabolism, were up-regulated by 21-fold under Ca(2+) -deficient conditions upstream of HsfA4a, reducing the ABA level in early embryos. Over-expression of AhCYP707A4 in Nicotiana benthamiana showed a phenotype of low ABA content with high numbers of aborted embryos, small pods and less seeds, which confirms that AhCYP707A4 is a key player in regulation of Ca(2+) deficiency-induced embryo abortion via ABA-mediated apoptosis. The results elucidated the mechanism of low Ca(2+) -induced embryo abortion and described the method for other fields of study.

  7. Generative Agents for Player Decision Modeling in Games

    DEFF Research Database (Denmark)

    Holmgård, Christoffer; Liapis, Antonios; Togelius, Julian;

    2014-01-01

    This paper presents a method for modeling player decision making through the use of agents as AI-driven personas. The paper argues that artificial agents, as generative player models, have properties that allow them to be used as psyhometrically valid, abstract simulations of a human player......’s internal decision making processes. Such agents can then be used to interpret human decision making, as personas and playtesting tools in the game design process, as baselines for adapting agents to mimic classes of human players, or as believable, human-like opponents. This argument is explored...... in a crowdsourced decision making experiment, in which the decisions of human players are recorded in a small-scale dungeon themed puzzle game. Human decisions are compared to the decisions of a number of a priori defined “archetypical” agent-personas, and the humans are characterized by their likeness...

  8. Role of JNK activation in apoptosis: A double-edged sword

    Institute of Scientific and Technical Information of China (English)

    Jing LIU; Anning LIN

    2005-01-01

    JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF-α induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies reveal that JNK can suppress apoptosis in IL-3-dependent hematopoietic cells via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Thus, JNK has pro- or antiapoptotic functions, depending on cell type, nature of the death stimulus, duration of its activation and the activity of other signaling pathways.

  9. Lower limb strength in professional soccer players: profile, asymmetry, and training age.

    Science.gov (United States)

    Fousekis, Konstantinos; Tsepis, Elias; Vagenas, George

    2010-01-01

    regarding proper training and injury prevention in relation to professional experience in soccer. Key pointsMuscle strength increased from the low (5-7 years) to the intermediate professional training age (8-10 years) and stabilized thereafter.Soccer practicing and competition at the professional level induces critical strength adaptations (asymmetries) regarding the function of the knee and ankle musculature.Soccer players with long professional training age showed a tendency for lower isokinetic strength asymmetries than players with intermediate and short professional training age.

  10. A Method for Using Player Tracking Data in Basketball to Learn Player Skills and Predict Team Performance.

    Directory of Open Access Journals (Sweden)

    Brian Skinner

    Full Text Available Player tracking data represents a revolutionary new data source for basketball analysis, in which essentially every aspect of a player's performance is tracked and can be analyzed numerically. We suggest a way by which this data set, when coupled with a network-style model of the offense that relates players' skills to the team's success at running different plays, can be used to automatically learn players' skills and predict the performance of untested 5-man lineups in a way that accounts for the interaction between players' respective skill sets. After developing a general analysis procedure, we present as an example a specific implementation of our method using a simplified network model. While player tracking data is not yet available in the public domain, we evaluate our model using simulated data and show that player skills can be accurately inferred by a simple statistical inference scheme. Finally, we use the model to analyze games from the 2011 playoff series between the Memphis Grizzlies and the Oklahoma City Thunder and we show that, even with a very limited data set, the model can consistently describe a player's interactions with a given lineup based only on his performance with a different lineup.

  11. Myeloid dendritic cells are potential players in human neurodegenerative diseases

    Directory of Open Access Journals (Sweden)

    Paola eBossù

    2015-12-01

    Full Text Available Alzheimer’s (AD and Parkinson’s (PD diseases are devastating neurodegenerative disturbances wherein neuroinflammation is a chronic pathogenic process with high therapeutic potential. Major mediators of AD/PD neuroimmune processes are resident immune cells, but immune cells derived from periphery may also participate and to some extent modify neuroinflammation. Specifically, blood borne myeloid cells emerge as crucial components of AD/PD progression and susceptibility. Among these, dendritic cells (DCs are key immune orchestrators and players of brain immune surveillance: we candidate them as potential mediators of both AD and PD and as relevant cell model for unraveling myeloid cell role in neurodegeneration. Hence, we recapitulate and discuss emerging data suggesting that blood-derived DCs play a role in experimental and human neurodegenerative diseases. In humans, in particular, DCs are modified by in vitro culture with neurodegeneration-associated pathogenic factors and dysregulated in AD patients, while the levels of DC precursors are decreased in AD and PD patients’ blood, possibly as an index of their recruitment to the brain. Overall, we emphasize the need to explore the impact of DCs on neurodegeneration to uncover peripheral immune mechanisms of pathogenic importance, recognize potential biomarkers and improve therapeutic approaches for neurodegenerative diseases.

  12. [CREB activation is a key player for ischemic tolerance in the brain].

    Science.gov (United States)

    Kitagawa, Kazuo; Sasaki, Tsutomu; Terasaki, Yasukazu; Yagita, Yoshiki; Mochizuki, Hideki

    2012-01-01

    Ischemic tolerance is as powerful and reproducible for neuro-protection as hypothermia. Several pathways could be involved in acquisition of ischemic tolerance. CREB is an abundant transcription factor in the brain and plays critical role on synaptic plasticity and neuronal survival. CREB activation has been also shown to be involved in ischemic tolerance. Ischemia or oxygen-glucose deprivation leads to release of glutamate, which binds to synaptic NMDA receptor. Then, influx of calcium ions into intracellular space activates calcium-calmodulin dependent protein kinase (CaMK). CaMK I/IV phosphorylates Ser 133 of CREB, and Thr 484 of salt-inducible kinase (SIK). Phosphorylation of SIK2 at Thr 484 triggers degradation of SIK2 through ubiquitin proteasome system. SIK2 maintains the phosphorylation level of CREB-regulated transcriptional co-activator (CRTC). Degradation of SIK2 induces dephosphorylation of CRTC1, and moves CRTC1 from cytoplasm into nucleus. Thus CRTC1 binds to basic ZIP domain of CREB. Both Ser133 phosphorylation and CRTC1 bound to the basic ZIP domain of CREB enhances CRE-mediated transcription, induces gene expression of survival factors, and renders the neurons resistant to subsequent severe ischemia.

  13. Key Players in I-DmoI Endonuclease Catalysis Revealed from Structure and Dynamics

    DEFF Research Database (Denmark)

    Molina, Rafael; Besker, Neva; Marcaida, Maria Jose;

    2016-01-01

    Homing endonucleases, such as I-DmoI, specifically recognize and cleave long DNA target sequences (∼20 bp) and are potentially powerful tools for genome manipulation. However, inefficient and off-target DNA cleavage seriously limits specific editing in complex genomes. One approach to overcome th...

  14. HGF/Met Signaling Is a Key Player in Malignant Mesothelioma Carcinogenesis

    Directory of Open Access Journals (Sweden)

    Giovanni Gaudino

    2014-11-01

    Full Text Available Malignant mesothelioma (MM is a highly aggressive cancer related to asbestos or erionite exposure and resistant to current therapies. Hepatocyte Growth Factor (HGF and its tyrosine kinase receptor Met regulate cell growth, survival, motility/migration, and invasion. HGF and Met are expressed in MM cells, suggesting that the HGF/Met signaling plays a role in development and progression of this tumor, by autocrine and/or paracrine mechanisms. Upregulation and ligand-independent activation of Met, which is under suppressive control of miR-34 family members, correlate with enhanced invasion, migration and metastatic potential in several cancers, including MM. Moreover, Simian Virus 40 (SV40 Tag expression also induces a HGF autocrine circuit in an Rb-dependent manner in human mesothelial cells (HM and possibly other cell types, enhancing cell adhesion, invasion and angiogenesis. The resulting activation of Met causes HM transformation and cell cycle progression, and contributes to virus particle assembling and infection of adjacent cells. The constitutive activation of Met, frequently occurring in MM, has been successfully targeted in preclinical models of MM. In conclusion, Met expression, activation state, subcellular localization and also HGF co-receptors expression, such as CD44, have clinical relevance for novel targeted therapies in a cancer for which no effective treatment is currently available.

  15. Nitric oxide (NO): a key player in the senescence of Medicago truncatula root nodules.

    Science.gov (United States)

    Cam, Yvan; Pierre, Olivier; Boncompagni, Eric; Hérouart, Didier; Meilhoc, Eliane; Bruand, Claude

    2012-10-01

    Nitric oxide (NO) is a signalling and defence molecule involved in diverse plant developmental processes, as well as in the plant response to pathogens. NO has also been detected at different steps of the symbiosis between legumes and rhizobia. NO is required for an optimal establishment of the Medicago truncatula-Sinorhizobium meliloti symbiotic interaction, but little is known about the role of NO in mature nodules. Here, we investigate the role of NO in the late steps of symbiosis. Genetic and pharmacological approaches were conducted to modulate the NO level inside root nodules, and their effects on nitrogen fixation and root nodule senescence were monitored. An increase in endogenous NO levels led to a decrease in nitrogen fixation and early nodule senescence, characterized by cytological modifications of the nodule structure and the early expression of a specific senescence marker. By contrast, a decrease in NO levels led to a delay in nodule senescence. Together, our results strongly suggest that NO is a signal in developmental as well as stress-induced nodule senescence. In addition, this work demonstrates the pivotal role of the bacterial NO detoxification response in the prevention of early nodule senescence, and hence the maintenance of efficient symbiosis.

  16. GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance

    DEFF Research Database (Denmark)

    Biensø, Rasmus Sjørup; Jørgensen, Stine Ringholm; Kiilerich, Kristian

    2012-01-01

    glycogen synthase (GS) was reduced with normal GS site 3 but abnormal GS site 2+2a phosphorylation after bed rest. Exercise enhanced insulin-stimulated leg glucose extraction both before and after bed rest, which was accompanied by higher GS activity in the prior-exercised leg than the rested leg...

  17. Heme metabolism in stress regulation and protein production: from Cinderella to a key player

    DEFF Research Database (Denmark)

    Martínez, J. L.; Petranovic, D.; Nielsen, Jens

    2016-01-01

    . Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its...... regulation could impact our ability to develop more efficient yeast cell factories for heterologous protein production....

  18. Gut microbiota as a key player in triggering obesity, systemic inflammation and insulin resistance.

    Science.gov (United States)

    Escobedo, Galileo; López-Ortiz, Eduardo; Torres-Castro, Israel

    2014-01-01

    Obesity-related systemic inflammation contributes to develop insulin resistance. The main factors involved in the relationship of obesity with systemic inflammation and insulin resistance have not been completely elucidated. Microbiota includes around 1013 to 1014 microbes harboring the human gut, which are clustered in approximately a thousand different bacterial species. Several studies suggest that imbalance in the intestinal bacterial population could result in obesity, systemic inflammation and metabolic dysfunction. Here, we review the main bacterial groups observed in obesity as well as their possible role in increasing the intestinal permeability and lipopolysaccharide-related endotoxemia. Furthermore, we point out the role of intestinal dysbiosis in the inflammatory activation of macrophages with the ability to infiltrate in the visceral adipose tissue and induce insulin resistance. Finally, we discuss the apparent beneficial use of prebiotics and probiotics in ameliorating both systemic inflammation and metabolic dysfunction. Present information may be useful in the future design of novel therapies focused on treating obesity and insulin resistance by restoring the gut microbiota balance.

  19. KEY PLAYERS IN INNATE IMMUNE RECOGNITION OF VIRUS INFECTION IN MAMMALS AND FISH

    OpenAIRE

    I Jakovlić; Zhang, Y.B.; WU, Q.J.; Jian-Fang Gui

    2006-01-01

    Viral infection of mammalian cells activates an innate antiviral immune response characterized by production of interferon and subsequent enhanced transcription of interferon–stimulated genes important for antiviral defense. Cells recognize viral infection through various pathogen–associated molecular patterns, of which dsRNA seems to be the most important. In mammals, several gene products are important in recognition of dsRNA: RIG–I, TLR3, PKR and mda–5. Recent research proved that fish pos...

  20. Neuropeptide W: a key player in the homeostatic regulation of feeding and energy metabolism?

    Science.gov (United States)

    Takenoya, Fumiko; Kageyama, Haruaki; Shiba, Kanako; Date, Yukari; Nakazato, Masamitsu; Shioda, Seiji

    2010-07-01

    Neuropeptide W (NPW), recently isolated from porcine hypothalamus, has been identified as the endogenous ligand for both NPBWR1 (GPR7) and NPBWR2 (GPR8), which belong to the orphan G protein-coupled receptor family. NPW is thought to play an important role in the regulation of feeding and drinking behavior, and to be related to the stress response. NPW-containing neurons are localized in several regions of the brain, including the hypothalamus, hippocampus, limbic system, midbrain, and brain stem. Accumulated evidence suggests that hypothalamic neuropeptides, such as neuropeptide Y (NPY), orexin, melanin-concentrating hormone (MCH), and proopiomelanocortin (POMC), are involved in the regulation of feeding behavior and energy homeostasis via neuronal circuits in the hypothalamus. NPW also forms part of the feeding-regulating neuronal circuitry in conjunction with other feeding-regulating peptide-containing neurons within the hypothalamus. We summarize our current understanding of the distribution of NPW and of the neuronal interactions between NPW and the different feeding-regulating peptide-containing neurons. This review also discusses evidence for the dichotomous actions of NPW on energy balance and the potential mechanisms involved.

  1. Adiponectin receptor as a key player in healthy longevity and obesity-related diseases.

    Science.gov (United States)

    Yamauchi, Toshimasa; Kadowaki, Takashi

    2013-02-05

    Adiponectin is a fat-derived hormone whose reduction plays central roles in obesity-linked diseases including insulin resistance/type 2 diabetes and atherosclerosis. The cloning of Adiponectin receptors AdipoR1 and AdipoR2 has stimulated adiponectin research, revealing pivotal roles for AdipoRs in pleiotropic adiponectin actions, as well as some postreceptor signaling mechanisms. Adiponectin signaling has thus become one of the major research fields in metabolism and clinical medicine. Studies on AdipoRs will further our understanding of the role of adiponectin in obesity-linked diseases and shortened life span and may guide the design of antidiabetic and antiaging drugs with AdipoR as a target.

  2. The cytochrome P450 superfamily:Key players in plant development and defense

    Institute of Scientific and Technical Information of China (English)

    XU Jun; WANG Xin-yu; GUO Wang-zhen

    2015-01-01

    The cytochrome P450 (CYP) superfamily is the largest enzymatic protein family in plants, and it also widely exists in mammals, fungi, bacteria, insects and so on. Members of this superfamily are involved in multiple metabolic pathways with distinct and complex functions, playing important roles in a vast array of reactions. As a result, numerous secondary metabolites are synthesized that function as growth and developmental signals or protect plants from various biotic and abiotic stresses. Here, we summarize the characterization of CYPs, as wel as their phylogenetic classiifcation. We also focus on recent advances in elucidating the roles of CYPs in mediating plant growth and development as wel as biotic and abiotic stresses responses, providing insights into their potential utilization in plant breeding.

  3. Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility

    DEFF Research Database (Denmark)

    Clausen, Thomas Mandel; Bento Ayres Pereira, Marina Maria; Al Nakouzi, Nader

    2016-01-01

    Many tumors express proteoglycans modified with oncofetal chondroitin sulfate glycosaminoglycan chains (ofCS), which are normally restricted to the placenta. However, the role of ofCS in cancer is largely unknown. The function of ofCS in cancer was analyzed using the recombinant ofCS-binding VAR2...

  4. RhoGTPases as Key Players in Mammalian Cell Adaptation to Microgravity

    OpenAIRE

    Fiona Louis; Christophe Deroanne; Betty Nusgens; Laurence Vico; Alain Guignandon

    2015-01-01

    A growing number of studies are revealing that cells reorganize their cytoskeleton when exposed to conditions of microgravity. Most, if not all, of the structural changes observed on flown cells can be explained by modulation of RhoGTPases, which are mechanosensitive switches responsible for cytoskeletal dynamics control. This review identifies general principles defining cell sensitivity to gravitational stresses. We discuss what is known about changes in cell shape, nucleus, and focal adhes...

  5. Memory CD8+ T Cells: Orchestrators and Key Players of Innate Immunity?

    Science.gov (United States)

    Lauvau, Grégoire; Goriely, Stanislas

    2016-09-01

    Over the past decades, the dichotomy between innate and adaptive immune responses has largely dominated our understanding of immunology. Upon primary encounter with microbial pathogens, differentiation of adaptive immune cells into functional effectors usually takes several days or even longer, making them contribute to host protection only late during primary infection. However, once generated, antigen-experienced T lymphocytes can persist in the organism and constitute a pool of memory cells that mediate fast and effective protection to a recall infection with the same microbial pathogen. Herein, we challenge this classical paradigm by highlighting the "innate nature" of memory CD8+ T cells. First, within the thymus or in the periphery, naïve CD8+ T cells may acquire phenotypic and functional characteristics of memory CD8+ T cells independently of challenge with foreign antigens. Second, both the "unconventional" and the "conventional" memory cells can rapidly express protective effector functions in response to sets of inflammatory cytokines and chemokines signals, independent of cognate antigen triggering. Third, memory CD8+ T cells can act by orchestrating the recruitment, activation, and licensing of innate cells, leading to broad antimicrobial states. Thus, collectively, memory CD8+ T cells may represent important actors of innate immune defenses.

  6. Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling.

    Science.gov (United States)

    Gill, Balraj Singh; Sharma, Prateek; Kumar, Raj; Kumar, Sanjeev

    2016-03-01

    A Basidiomycetes fungus belonging to polypore family of mushrooms, Ganoderma lucidum (GL), has been known since a long time for their myriad therapeutic indications. Renowned as an invaluable resource of cardinal mycoconstituents they encompass numerous terpenoids polysaccharides and proteins. Possessing the therapeutically potent lanosteroidal skeleton, terpenoids are upheld for their invariable participation in therapeutically diverse bioactivities. Polysaccharides and proteins exhibiting distinguishable bioactivities provide this oriental mushroom with additional edges over immune function and anti-cancer potential. This review is a concerted effort to throw light upon the therapeutic versatility of the fungus, shadowed by various other natural products. An effort has been made towards conglomerating the mycoconstituents decisive for the many activities portrayed by this fungus. More importantly, this review seeks to fathom the inextricable role played by derivatives in modulating signaling cascades such as downregulation of various mitogenic pathways, inhibiting growth factors, or upregulating certain pathways enhancing cellular integrity.

  7. B-Raf mutation: a key player in molecular biology of cancer.

    Science.gov (United States)

    Rahman, M A; Salajegheh, A; Smith, R A; Lam, A K-Y

    2013-12-01

    B-Raf is one of the more commonly mutated proto-oncogenes implicated in the development of cancers. In this review, we consider the mechanisms and clinical impacts of B-Raf mutations in cancer and discuss the implications for the patient in melanoma, thyroid cancer and colorectal cancer, where B-Raf mutations are particularly common.

  8. Mucosal biomarkers in inflammatory bowel disease:Key pathogenic players or disease predictors?

    Institute of Scientific and Technical Information of China (English)

    Franco; Scaldaferrii; Carmen; Correale; Antonio; Gasbarrini; Silvio; Danese

    2010-01-01

    Inflammatory bowel diseases(IBDs) are chronic inflammatory disorders of the bowel,including ulcerative colitis and Crohn's disease.A single etiology has not been identified,but rather the pathogenesis of IBD is very complex and involves several major and minor contributors,employing different inflammatory pathways which have different roles in different patients.Although new and powerful medical treatments are available,many are biological drugs or immunosuppressants,which are associated with significant si...

  9. Key Players in the Genetic Switch of Bacteriophage TP901-1

    DEFF Research Database (Denmark)

    Alsing, Anne; Pedersen, Margit; Sneppen, Kim;

    2011-01-01

    After infection of a sensitive host temperate phages may enter either a lytic or a lysogenic pathway leading to new phage assembly or silencing as a prophage, respectively. The decision about which pathway to enter is centered in the genetic switch of the phage. In this work, we explore the bista......After infection of a sensitive host temperate phages may enter either a lytic or a lysogenic pathway leading to new phage assembly or silencing as a prophage, respectively. The decision about which pathway to enter is centered in the genetic switch of the phage. In this work, we explore...... the bistable genetic switch of bacteriophage TP901-1 through experiments and statistical mechanical modeling. We examine the activity of the lysogenic promoter Pr at different concentrations of the phage repressor, CI, and compare the effect of CI on Pr in the presence or absence of the phage-encoded MOR...... protein expressed from the lytic promoter Pl. We find that the presence of large amounts of MOR prevents repression of the Pr promoter, verifying that MOR works as an antirepressor. We compare our experimental data with simulations based on previous mathematical formulations of this switch. Good agreement...

  10. Key Player in Maersk Alabama Hostage Rescue Addresses NPS Students During Guest Lecture

    OpenAIRE

    Naval Postgraduate School Public Affairs Office

    2012-01-01

    Renowned Naval Postgraduate School (NPS) alumnus and former USS Bainbridge (DDG-96) commander, U.S. Navy Capt. Frank Castellano, recently addressed students and faculty at NPS’ King Auditorium, Oct. 16.

  11. Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches

    Directory of Open Access Journals (Sweden)

    Suvi E. Heinonen

    2015-01-01

    Full Text Available Diabetes mellitus is a lifelong, incapacitating metabolic disease associated with chronic macrovascular complications (coronary heart disease, stroke, and peripheral vascular disease and microvascular disorders leading to damage of the kidneys (nephropathy and eyes (retinopathy. Based on the current trends, the rising prevalence of diabetes worldwide will lead to increased cardiovascular morbidity and mortality. Therefore, novel means to prevent and treat these complications are needed. Under the auspices of the IMI (Innovative Medicines Initiative, the SUMMIT (SUrrogate markers for Micro- and Macrovascular hard end points for Innovative diabetes Tools consortium is working on the development of novel animal models that better replicate vascular complications of diabetes and on the characterization of the available models. In the past years, with the high level of genomic information available and more advanced molecular tools, a very large number of models has been created. Selecting the right model for a specific study is not a trivial task and will have an impact on the study results and their interpretation. This review gathers information on the available experimental animal models of diabetic macrovascular complications and evaluates their pros and cons for research purposes as well as for drug development.

  12. Bone Mineral Density of Adolescent Female Tennis Players and Nontennis Players

    Directory of Open Access Journals (Sweden)

    Kevser Ermin

    2012-01-01

    Full Text Available The purpose of this study was to determine differences in bone mineral density (BMD among adolescent female tennis players (TPs and nontennis players (NTPs and to assess body composition as a predictor variable of BMD. Nineteen female TPs and 19 female NTPs, ages 14 to 18 years, participated in this study. Lumbar spine, total hip, femoral neck, forearms BMD, and body composition were assessed using dual-energy X-ray absorptiometry (DXA. Lumbar spine and total hip BMD measurements for TP were greater than NTP. However, these differences were not statistically significant (=0.37 and 0.12, resp.. TP had significantly greater femoral neck BMD than NTPs (=0.02. This difference might play an important role in preventing osteoporosis and decreasing the risk of fractures at the hip later in life.

  13. The changing shape of mitochondrial apoptosis.

    Science.gov (United States)

    Wasilewski, Michał; Scorrano, Luca

    2009-08-01

    Mitochondria are key organelles in conversion of energy, regulation of cellular signaling and amplification of programmed cell death. The anatomy of the organelle matches this functional versatility in complexity and is modulated by the concerted action of proteins that impinge on its fusion-fission equilibrium. A growing body of evidence implicates changes in mitochondrial shape in the progression of apoptosis and, therefore, proteins governing such changes are likely candidates for involvement in pathogenetic mechanisms in neurodegeneration and cancer. Here, we discuss the recent advancements in our knowledge about the machinery that regulates mitochondrial shape and on the role of molecular mechanisms controlling mitochondrial morphology during cell death.

  14. Has player development in men's tennis really changed? An historical rankings perspective.

    Science.gov (United States)

    Bane, Michael Kenneth; Reid, Machar; Morgan, Stuart

    2014-01-01

    Tennis federations are regularly faced with decisions regarding which athletes should be supported in financial terms, and for how long. The financial investments can be considerable, given the cost of competing on tour has been estimated at a minimum $121,000 per year and only the top 130 professionally ranked athletes earned enough prize money to cover this cost in 2012. This study investigates key points of progression in tennis players' careers, to determine how these have changed over time and how that evolution may inform talent development. Approximately 400,000 weekly rankings for 273 male professional tennis players between 1985 and 2010 were compiled, and historical trends in the time taken to reach career milestones were investigated by least-squares regression. The time between earning a first professional ranking point and entry into the Top 100 significantly increased over time for all considered athletes. This was at the detriment of time spent within the Top 100 for some athletes. Career peak Top 50-100 athletes have shown an increase in longevity. These results assist tennis federations in assessing the progress of developing athletes and highlight the evolving nature of the competition for top players.

  15. Coach/player relationships in tennis.

    Science.gov (United States)

    Prapavessis, H; Gordon, S

    1991-09-01

    The present study examined the variables that predict coach/athlete compatibility. Compatibility among a sample of 52 elite tennis coach/player dyads was assessed using a sport adapted version of Schutz's (1966) Fundamental Interpersonal Relations Orientation-Behaviour (FIRO-B), a sport adapted version of Fiedler's (1967) Least Preferred Co-worker scale (LPC), and Chelladurai and Saleh's (1980) Leadership Scale for Sport (LSS). Self-ratings of the quality of the interaction were obtained from both coach and athlete. Multiple-regression analyses using self-rating scores as the dependent measure were carried out to determine which variables best predicted the degree of compatibility. The sole inventory that significantly predicted compatibility was the LSS. More specifically, the discrepancy between the athlete's preferences and perceptions on the autocratic dimension was the best predictor. Implications for tennis coaches and recommendations for future research in this area are discussed.

  16. Gamification in Fostering Creativity: Player Type Approach

    Directory of Open Access Journals (Sweden)

    Marius Kalinauskas

    2015-02-01

    Full Text Available Purpose – to analyze gamification, as the method for promoting creativity in individual and collective levels with the respect to player types.Design/methodology/approach – This research serves as a general review/viewpoint which seeks to examine collective creativity as a phenomenon and gamification as the tool for promoting individual and collective creativity. The paper is based on the comparative analysis of scientific literature and related sources from game design, psychology, business and entertainment.Findings – Although the gamification is gaining more public attention, there is a lack of studies which would reveal its relations in fostering individual and collective creativity. One of the main goals of any gamified content is to raise the engagement into activities in non-game contexts. The objective of creative work is to come up with some ideas, methods or tools which would be significantly new and innovative in the case of a certain issue. The theory of “flow” is used widely in explaining the working principles of gamification. In this state, the information absorption rates are increased and the group or individual is immersed into performed activities. This may lead to prolonged periods while accumulating knowledge, and thus, improving creative capabilities in the specific domain. However, creative performance in different fields has various approaches. It is also related to personal characteristics. The success of gamification is also dependent on the types of “players” which participate in the activity. Having the common picture of personality type in creative performance and in game based tasks may allow creating gamification strategy for optimal engagement into creative work according to the features of a person.Research limitations/implications – There are very few empirical studies which would support correlation between experiencing the “flow” state and a raise of creativity. The idea of unified

  17. Sympathetic enhancement in futsal players but not in football players after repeated sprint ability test

    OpenAIRE

    Chen, Yung-Sheng; Liao, Chih-Jung; Lu, Wan-An; Kuo, Cheng-Deng

    2015-01-01

    Background Heart rate variability (HRV) can disclose the specific adaptation of sympathovagal modulation to exercise. This study investigated the change in HRV measures after anaerobic and aerobic intermittent exercises in university football and futsal players. Method 36 male university students with physically active lifestyle (n=14), football (n=12), and futsal (n=10) participated in this study. The participants completed the repeated sprint ability (RSA) test and Yo-Yo (YY) intermittent r...

  18. Apoptosis and DNA Methylation

    Energy Technology Data Exchange (ETDEWEB)

    Meng, Huan X.; Hackett, James A. [MRC Human Genetics Unit, IGMM, Western General Hospital, Edinburgh EH4 2XU (United Kingdom); Nestor, Colm [MRC Human Genetics Unit, IGMM, Western General Hospital, Edinburgh EH4 2XU (United Kingdom); Breakthrough Research Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU (United Kingdom); Dunican, Donncha S.; Madej, Monika; Reddington, James P. [MRC Human Genetics Unit, IGMM, Western General Hospital, Edinburgh EH4 2XU (United Kingdom); Pennings, Sari [Queen' s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ (United Kingdom); Harrison, David J. [Breakthrough Research Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU (United Kingdom); Meehan, Richard R., E-mail: Richard.Meehan@hgu.mrc.ac.uk [MRC Human Genetics Unit, IGMM, Western General Hospital, Edinburgh EH4 2XU (United Kingdom); Breakthrough Research Unit, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU (United Kingdom)

    2011-04-01

    Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.

  19. Apoptosis and DNA Methylation

    Directory of Open Access Journals (Sweden)

    Richard R. Meehan

    2011-04-01

    Full Text Available Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.

  20. University Football Players, Postural Stability, and Concussions.

    Science.gov (United States)

    Graves, Barbara Sue

    2016-02-01

    Concussion in football athletes is certainly more prevalent and has potentially serious outcomes. With current concerns and increasing return-to-play issues, additional assessment focus is needed. Division 1 college football athletes, from 18 to 20.9 years (n = 177; age, 19.7 ± 1.2 years; height, 182.3 ± 4.5 cm; weight, 97.3 ± 10.6 kg), before fall practice, over a period of 3 years, underwent baseline postural stability testing (sensory organization test [SOT], NeuroCom). Individuals, who were diagnosed with a concussion (headache, dizziness, fatigue, confusion, or loss of consciousness) during practice or actual competition (n = 15; age, 18.9 ± 0.9 years; height, 181.8 ± 2.5 cm; weight, 86.6 ± 3.6 kg), underwent serial evaluation after injury and 24 hours after concussion. As soon as the player was considered asymptomatic, the test was completed on the first and 14th day. A control group of noninjured male athletes (n = 15; age, 19.1 ± 0.4 years; height, 178.2 ± 3.2 cm; weight, 78.6 ± 2.1 kg) were tested for the same time frame. This particular study was only one part of the total evaluation conducted for the concussed athlete's return to play. Results indicated that the concussion group had a statistically significant (p = 0.037) change from their baseline SOT score and the control group (p = 0.025). This change remained significant until day 14 of posttesting. These data indicate that the SOT, when available, may be a positive additional assessment of concussed college-aged football players. Professionals, when dealing with concussion in competitive sports, do need to continue to work together, but awareness of SOT assessments may also contribute to the return-to-play decisions.

  1. Apoptosis and oxidative stress in neurodegenerative diseases.

    Science.gov (United States)

    Radi, Elena; Formichi, Patrizia; Battisti, Carla; Federico, Antonio

    2014-01-01

    Neurodegenerative disorders affect almost 30 million individuals leading to disability and death. These disorders are characterized by pathological changes in disease-specific areas of the brain and degeneration of distinct neuron subsets. Despite the differences in clinical manifestations and neuronal vulnerability, the pathological processes appear similar, suggesting common neurodegenerative pathways. Apoptosis seems to play a key role in the progression of several neurologic disorders like Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis as demonstrated by studies on animal models and cell lines. On the other hand, research on human brains reported contradictory results. However, many dying neurons have been detected in brains of patients with neurodegenerative diseases, and these conditions are often associated with significant cell loss accompanied by typical morphological features of apoptosis such as chromatin condensation, DNA fragmentation, and activation of cysteine-proteases, caspases. Cell death and neurodegenerative conditions have been linked to oxidative stress and imbalance between generation of free radicals and antioxidant defenses. Multiple sclerosis, stroke, and neurodegenerative diseases have been associated with reactive oxygen species and nitric oxide. Here we present an overview of the involvement of neuronal apoptosis and oxidative stress in the most important neurodegenerative diseases, mainly focusing the attention on several genetic disorders, discussing the interaction between primary genetic abnormalities and the apoptotic pathways.

  2. Cervical range of motion and proprioception in rugby players versus non-rugby players.

    Science.gov (United States)

    Lark, Sally D; McCarthy, Peter W

    2007-06-01

    In this study, we examined the effects of number of years of playing rugby on neck function. Active cervical spine range of motion and proprioception were assessed in 14 non-rugby-playing but trained sportsmen (mean age 28 years, s = 7) and 46 rugby players (26 rugby forwards: mean age 26 years, s = 5; mean years played 14 years; 20 backs: mean age 24 years, s = 5; mean years played 14 years). Active cervical range of motion in flexion, extension, left and right lateral flexion, plus left and right rotation were measured using a cervical range of motion device. The ability to reposition the head in a central position with eyes closed was taken as a measure of proprioception. Results show that rugby forwards generally had the least active cervical range of motion, particularly neck extension (forwards, 43 degrees ; backs, 55 degrees ; controls, 58 degrees ), with the decrement correlating with the number of years played. In addition, repositioning was significantly worse in rugby players after neck extension than non-rugby players (6 degrees vs. 3 degrees ). The active cervical range of motion of rugby forwards is similar to that of whiplash patients, suggesting that participation in rugby can have an effect on neck range of motion that is equivalent to chronic disability. Reduced active cervical range of motion could also increase the likelihood of injury and exacerbate age-related neck problems.

  3. SPORTS SHOES PURCHASE INTENTION AMONG MALAYSIAN VOLLEYBALL PLAYERS VS. NON-VOLLEYBALL PLAYERS: A CONCEPTUAL PAPER

    Directory of Open Access Journals (Sweden)

    GOH PIN SIANG

    2013-12-01

    Full Text Available The purpose of this study is to advance the understanding of volleyball players’ purchase intention toward sport shoes by investigating the relationship between the independent variables (endorsement, advertising, pricing and electronic word-of-mouth and purchase intention. Descriptive research and causal research will be used as the research design, thus questionnaire and experimentation will be used to obtain data. Primary data in this study is attained by distributing the questionnaire to the Malaysian volleyball players throughout several volleyball tournament venues in Malaysia. The experiment will be conducted by comparing two groups of respondents, including volleyball players and non-volleyball players. This study is limited to several independent variables such as endorsement, advertising, pricing and electronic word-of-mouth. This study is significant for marketers for solving the challenges faced in the sport industry. It also helps to identify consumers’ purchase preferences for sport shoes. The marketer would understand more about their targeted customers’ intentions to purchase, thus the sport industry related with sport marketing in Malaysia might gain more profit.

  4. Apoptosis Resistance in Endometriosis

    Directory of Open Access Journals (Sweden)

    Liselotte Mettler

    2011-08-01

    Full Text Available Introduction: In a cytological analysis of endometriotic lesions neither granulocytes nor cytotoxic T-cells appear in an appreciable number. Based on this observation we aimed to know, whether programmed cell death plays an essential role in the destruction of dystopic endometrium. Disturbances of the physiological mechanisms of apoptosis, a persistence of endometrial tissue could explain the disease. Another aspect of this consideration is the proliferation competence of the dystopic mucous membrane. Methods: Endometriotic lesions of 15 patients were examined through a combined measurement of apoptosis activity with the TUNEL technique (terminal deoxyribosyltransferase mediated dUTP Nick End Labeling and the proliferation activity (with the help of the Ki-67-Antigens using the monoclonal antibody Ki-S5. Results: Twelve out of 15 women studied showed a positive apoptotic activity of 3-47% with a proliferation activity of 2-25% of epithelial cells. Therefore we concluded that the persistence of dystopic endometrium requires proliferative epithelial cells from middle to lower endometrial layers. Conclusion: A dystopia misalignment of the epithelia of the upper layers of the functionalism can be rapidly eliminated by apoptotic procedures.

  5. Active tuning of stroke-induced vibrations by tennis players.

    Science.gov (United States)

    Chadefaux, Delphine; Rao, Guillaume; Androuet, Philippe; Berton, Eric; Vigouroux, Laurent

    2016-09-06

    This paper investigates how tennis players control stroke-induced vibration. Its aim is to characterise how a tennis player deals with entering vibration waves or how he/she has the ability to finely adjust them. A specific experimental procedure was designed, based on simultaneously collecting sets of kinematic, vibration and electromyographic data during forehand strokes using various commercial rackets and stroke intensities. Using 14 expert players, a wide range of excitations at spectral and temporal levels were investigated. Energetic and spectral descriptors of stroke-induced vibration occurring at the racket handle and at the player's wrist and elbow were computed. Results indicated that vibrational characteristics are strongly governed by grip force and to a lower extent by the racket properties. Grip force management drives the amount of energy, as well as its distribution, into the forearm. Furthermore, hand-grip can be assimilated to an adaptive filter which can significantly modify the spectral parameters propagating into the player's upper limb. A significant outcome is that these spectral characteristics are as much dependent on the player as on the racket. This contribution opens up new perspectives in equipment manufacture by underlining the need to account for player/racket interaction in the design process.

  6. Throwing speed and accuracy in baseball and cricket players.

    Science.gov (United States)

    Freeston, Jonathan; Rooney, Kieron

    2014-06-01

    Throwing speed and accuracy are both critical to sports performance but cannot be optimized simultaneously. This speed-accuracy trade-off (SATO) is evident across a number of throwing groups but remains poorly understood. The goal was to describe the SATO in baseball and cricket players and determine the speed that optimizes accuracy. 20 grade-level baseball and cricket players performed 10 throws at 80% and 100% of maximal throwing speed (MTS) toward a cricket stump. Baseball players then performed a further 10 throws at 70%, 80%, 90%, and 100% of MTS toward a circular target. Baseball players threw faster with greater accuracy than cricket players at both speeds. Both groups demonstrated a significant SATO as vertical error increased with increases in speed; the trade-off was worse for cricketers than baseball players. Accuracy was optimized at 70% of MTS for baseballers. Throwing athletes should decrease speed when accuracy is critical. Cricket players could adopt baseball-training practices to improve throwing performance.

  7. A Novel Music Player Controlling Design Based on Gesture Recognition

    Directory of Open Access Journals (Sweden)

    Yi Liu

    2014-01-01

    Full Text Available This study has proposed a novel music player controlling method based on gesture recognition, which translating the gesture interacting signal into a controlling instruction for the music player. Firstly, utilizing the laptop’s webcam to capture the image information, and then employing the image processing method to tackle it. The skin color detection was used to obtain the information of gesture candidates, and a background subtraction was introduced to eliminate the distributing information. Moreover, in order to ensure the rapid and effective implementation of music player proposed here, the barycenter of a gesture was calculated as one Recognized Reference Information (RRI; a ratio between the gesture’s width and height was also selected as the other RRI; the comparison of these two RRI values was utilized to obtain a pattern signal of the gesture which was corresponding to the controlling instruction for the Music Player. Eventually, a Music Player was programmed and the pattern signal generated by gesture recognition was used to control the Music Player as willing to realize four basic functions: “play”, “pause”, “previous” and “next”. A series of tests using our gesture recognition based Music Player was conducted under the condition with different kinds of complex backgrounds, and the results showed the satisfactory performance of our interactive designing.

  8. Physical performance of elite and subelite Spanish female futsal players

    Science.gov (United States)

    Rubio-Arias, JA; Carrasco-Poyatos, M; Alcaraz, PE

    2016-01-01

    The aim of this study was to determine the parameters distinguishing top female futsal players from lower level players. Twenty-seven female futsal players participated in the study, composed of professional first division (elite; n = 15) players and semi-professional second division players (sub-elite; n = 14). Active and passive straight leg raise tests, isokinetic strength of the knee extensor and flexor muscles at 60° · s-1 angular velocity, squat and counter movement jumps, 30 m sprint, 30 m agility, repeated sprint ability test and maximum ball speed during shooting were measured. The elite players were more agile and kicked harder than sub-elite players in maximum ball speed during the shooting test (P ≤ 0.05). However, no significant differences between teams were observed in active and passive hamstring flexibility, jumping ability, repeated sprint ability test, 30 m sprint time, H/Q ratio and absolute and relative torque from 60° · s-1 angular velocity. Based on these findings we conclude that agility and maximum ball speed during shooting may be important determinant factors of Spanish female futsal actions and could distinguish ability at high-level games. PMID:27601786

  9. Somatotype, size and body composition of competitive female volleyball players.

    Science.gov (United States)

    Malousaris, Grigoris G; Bergeles, Nikolaos K; Barzouka, Karolina G; Bayios, Ioannis A; Nassis, George P; Koskolou, Maria D

    2008-06-01

    The aim of this study was to describe the morphological characteristics of competitive female volleyball players. For this purpose, body weight and height, breadths and girths as well as skinfold thickness at various body sites were assessed in 163 elite female volleyball players (age: 23.8+/-4.7 years, years of playing: 11.5+/-4.2, hours of training per week: 11.9+/-2.9, means+/-S.D.). Seventy-nine of these players were from the A1 division and the rest from the A2 division of the Greek National League. Two-way ANOVA was used to compare the differences in these characteristics between competition level and playing position. Body height ranged from 161cm to 194cm, and the mean value (177.1+/-6.5cm) was not inferior to that of international players of similar calibre. Adiposity of these players (sum of 5 skinfolds: 51.8+/-10.2mm, percent body fat: 23.4+/-2.8) was higher than that reported in other studies in which, however, different methodology was used. Volleyball athletes of this study were mainly balanced endomorphs (3.4-2.7-2.9). The A1 division players were taller and slightly leaner with greater fat-free mass than their A2 counterparts. Significant differences were found among athletes of different playing positions which are interpreted by their varying roles and physical demands during a volleyball game. The volleyball players who play as opposites were the only subgroup of players differing between divisions; the A2 opposites had more body fat than A1 opposites. These data could be added in the international literature related to the anthropometric characteristics of competitive female volleyball players.

  10. A Profile of Fitness Parameters and Performance of Volleyball Players

    Directory of Open Access Journals (Sweden)

    Govind B. Taware

    2013-07-01

    Full Text Available Background: Ball games require comprehen-sive ability including physical, technical, men-tal and tactical abilities. Among them, physicalabilities of players exert marked effects on theskill of the players themselves and the tacticsof the team. Therefore players must have thephysical abilities to meet the demand of thesport. Volleyball is one of the most popularlyplayed games in the world. Unfortunately, thelevel of performance of the Indian volleyballplayers lags far behind the international stan-dards. Aim of the Study: The present study wasaimed to assess flexibility, muscular endurance,power and cardio-respiratory endurance of vol-leyball players and to compare the results withage matched controls. Also, to compare thefindings of the volleyball players with that ofthe international norms from the available lit-erature and to make some suggestions for theimprovement in their performance level. Ma-terial and Methods: The study was carried outin 40 male volleyball players aged between 17to 26 years and 40 ages matched male controls.Physical fitness parameters namely flexibility,muscular endurance, power and cardio-respi-ratory endurance were measured, data was ana-lyzed using unpaired ‘t’-test. Results: It was ob-served that all physical fitness parameters weresignificantly more in players as compared totheir aged-matched controls but when values ofthe subjects were compared to internationalstandards; our subjects were behind the recom-mended norms for the elite volleyball players.Conclusion: The volleyball players have moreadvantage of flexibility muscular endurance,power and cardio-respiratory endurance.

  11. Apoptosis : Target of cancer therapy

    NARCIS (Netherlands)

    Ferreira, CG; Epping, M; Kruyt, FAE; Giaccone, G

    2002-01-01

    Recent knowledge on apoptosis has made it possible to devise novel approaches, which exploit this process to treat cancer. In this review, we discuss in detail approaches to induce tumor cell apoptosis, their mechanism of action, stage of development, and possible drawbacks. Finally, the obstacles y

  12. Cryptographically Blinded Games: Leveraging Players' Limitations for Equilibria and Profit

    DEFF Research Database (Denmark)

    Hubacek, Pavel; Park, Sunoo

    2014-01-01

    In this work we apply methods from cryptography to enable mutually distrusting players to implement broad classes of mediated equilibria of strategic games without trusted mediation. Our implementation uses a pre-play 'cheap talk' phase, consisting of non- binding communication between players pr...... prior to play in the original game. In the cheap talk phase, the players run a secure multi-party computation protocol to sample from an equilibrium of a "cryptographically blinded" version of the game, in which actions are encrypted...

  13. Design of a WAV audio player based on K20

    Directory of Open Access Journals (Sweden)

    Xu Yu

    2016-01-01

    Full Text Available The designed player uses the Freescale Company’s MK20DX128VLH7 as the core control ship, and its hardware platform is equipped with VS1003 audio decoder, OLED display interface, USB interface and SD card slot. The player uses the open source embedded real-time operating system μC/OS-II, Freescale USB Stack V4.1.1 and FATFS, and a graphical user interface is developed to improve the user experience based on CGUI. In general, the designed WAV audio player has a strong applicability and a good practical value.

  14. Management of female handball players' activity applying interactive technologies

    Directory of Open Access Journals (Sweden)

    Frolova L.S.

    2012-04-01

    Full Text Available The efficiency of developed methods for the control of female handball players' readiness to competitive activity was determined. The opportunities of team management regarding the specification of playing role, the formation of the starting line of players and the replacement according to game priorities in attack or defense were considered. The availability of the adequate zone of handball players' mobilizing readiness that allows to have a significant influence on individual effectiveness in the conditions of optimal management and to increase the quality of team game was determined.

  15. CAREER TRANSITION FROM JUNIOR TO SENIOR IN BASKETBALL PLAYERS

    Directory of Open Access Journals (Sweden)

    Alberto Lorenzo

    2009-01-01

    Full Text Available The purpose of the study was to investigate what factors affect basketball players in the transition from junior and amateur to senior and professional sport respectively. The study was a qualitative research which uses a semi-structured interview to get the data. There were interviewed five Spanish basketball players who were starting playing in a team of Basketball Club Association (C.B.A.. The results showed that the participants face several changes both in the sport and in the life outside sport. At the same time, the results indicated the existence of several coping strategies that help the player in his career transition.

  16. Repeated sprint ability in elite water polo players and swimmers and its relationship to aerobic and anaerobic performance.

    Science.gov (United States)

    Meckel, Yoav; Bishop, David; Rabinovich, Moran; Kaufman, Leonid; Nemet, Dan; Eliakim, Alon

    2013-01-01

    The purpose of this study was to determine indices of swimming repeated sprint ability (RSA) in 19 elite water polo players compared to 16 elite swimmers during a repeated sprint swimming test (RST), and to examine the relationships between these indices and aerobic and anaerobic performance capabilities in both groups. Indices of RSA were determined by the ideal sprint time (IS), the total sprint time (TS), and the performance decrement (PD) recorded during an 8 x 15-m swimming RST. Single long - (800-m) and short-(25-m) distance swim tests were used to determined indices of aerobic and anaerobic swimming capabilities, respectively. The water polo players exhibited lower RSA swimming indices, as well as lower scores in the single short and long swim distances, compared to the swimmers. Significant relationships were found between the 25- m swim results and the IS and the TS, but not the PD of both the swimmers and the water polo players. No significant relationships were found between the 800-m swim results and any of the RSA indices in either the swimmers or the water polo players. No significant relationships were found between the 25-m and the 800-m swim results in either the swimmers or the water polo players. The results indicate that swimmers posses better RSA as well as higher anaerobic and aerobic capabilities, as reflected by the single short- and long-distance swim tests, compared to water polo players. The results also indicate that, as for running and cycling, repeated sprint swim performance is strongly related to single sprint performance. Key PointsElite water polo players demonstrated lower repeated sprint ability (RSA), aerobic and anaerobic capabilities compared to elite swimmers.A 25-m swim trial correlated significantly with ideal sprint time and total sprint time, emphasizing the important contribution of anaerobic metabolism for these exercise types in both water polo players and swimmers.800-m swim results did not correlate with RSA or 25-m

  17. Apoptosis Evaluation by Electrochemical Techniques.

    Science.gov (United States)

    Yin, Jian; Miao, Peng

    2016-03-01

    Apoptosis has close relevance to pathology, pharmacology, and toxicology. Accurate and convenient detection of apoptosis would be beneficial for biological study, clinical diagnosis, and drug development. Based on distinct features of apoptotic cells, a diversity of analytical techniques have been exploited for sensitive analysis of apoptosis, such as surface plasmon resonance, electrochemical methods, flow cytometry, and some imaging assays. Among them, the features of simplicity, easy operation, low cost, and high sensitivity make electrochemical techniques powerful tools to investigate electron-transfer processes of in vitro biological systems. In this contribution, a general overview of current knowledge on various technical approaches for apoptosis evaluation is provided. Furthermore, recently developed electrochemical biosensors for detecting apoptotic cells and their advantages over traditional methods are summarized. One of the main considerations focuses on designing the recognition elements based on various biochemical events during apoptosis.

  18. Caspase Family Proteases and Apoptosis

    Institute of Scientific and Technical Information of China (English)

    Ting-Jun FAN; Li-Hui HAN; Ri-Shan CONG; Jin LIANG

    2005-01-01

    Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction, transduction and amplification of intracellular apoptotic signals. Caspases, closely associated with apoptosis, are aspartate-specific cysteine proteases and members of the interleukin-1β-converting enzyme family. The activation and function of caspases, involved in the delicate caspase-cascade system, are regulated by various kinds of molecules, such as the inhibitor of apoptosis protein, Bcl-2 family proteins, calpain,and Ca2+. Based on the latest research, the members of the caspase family, caspase-cascade system and caspase-regulating molecules involved in apoptosis are reviewed.

  19. Advance research in apoptosis mediating by death receptor

    Institute of Scientific and Technical Information of China (English)

    JI Yu-bin; LIU Hong-juan; JI Chen-feng; ZHANG He

    2008-01-01

    Apoptosis is one of the main types of programmed cell deaths (PCD) and involves a series of biochemical events that lead to a variety of morphological changes and death. The initial and progress of apoptosis is precisely regulated. This review will summarize current knowledge of the signal transduction pathways of apoptosis. It is now well-established that the apoptotic signals generally involve the extrinsic or intrinsic pathways of apoptosis. The extrinsic pathway originates at the membrane and engages cell surface death receptors whereas the intrinsic pathway predominantly involves mitochondria. In the intrinsic pathway, the cell death signal induced changes of mitochondrial membrane permeability and the loss of membrane potential. Many proteins factors released, and then cytoplasmic cytochrome C and easpase-9 form of apoptosis. The activated caspase-9 cut caspase-3, then cell dead at last. In the case of extrinsic pathway, several death receptors exist including Fas, TNFR-1, DR3, DR4, DR5 and DR6. These death receptors contain an intracellular region of approximately 80 amino acids that is designated as "death domain". The death domain is an important structure that plays a key role in the transduction of apoptotic signals. The interaction between Fas and its ligand (FasL) triggers the formation of a death-inducing signaling complex (DISC), which subsequently recruits and activates caspase-8; this in turn activates other procaspases and culminates in the cleavage of cellular substrates and apoptosis. During the process of tumor cell lines apoptosis Inducted by chemotherapy. It is easy to see the increasing of the Fas receptors and inducing of FasL expression, it can inhibite apoptosis when the blocking Fas / FasL. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a type Ⅱ transmembrane protein belonging to the TNF family of death ligands. TRAIL has been suggested as a safe and tumorselective anticancer agent with low toxicity to normal

  20. Cl- channels in apoptosis

    DEFF Research Database (Denmark)

    Wanitchakool, Podchanart; Ousingsawat, Jiraporn; Sirianant, Lalida

    2016-01-01

    , and cystic fibrosis transmembrane conductance regulator (CFTR) in cellular apoptosis. LRRC8A-E has been identified as a volume-regulated anion channel expressed in many cell types. It was shown to be required for regulatory and apoptotic volume decrease (RVD, AVD) in cultured cell lines. Its presence also......(-) channels or as regulators of other apoptotic Cl(-) channels, such as LRRC8. CFTR has been known for its proapoptotic effects for some time, and this effect may be based on glutathione release from the cell and increase in cytosolic reactive oxygen species (ROS). Although we find that CFTR is activated...... by cell swelling, it is possible that CFTR serves RVD/AVD through accumulation of ROS and activation of independent membrane channels such as ANO6. Thus activation of ANO6 will support cell shrinkage and induce additional apoptotic events, such as membrane phospholipid scrambling....

  1. Young Football Players Tackle Greatest Concussion Risk At Practice

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_160579.html Young Football Players Tackle Greatest Concussion Risk at Practice But ... Children under the age of 14 who play football are at risk of concussions, and a small ...

  2. Real-Time Game Adaptation for Optimizing Player Satisfaction

    DEFF Research Database (Denmark)

    Yannakakis, Georgios; Hallam, John

    2009-01-01

    A methodology for optimizing player satisfaction in games on the "playware" physical interactive platform is demonstrated in this paper. Previously constructed artificial neural network user models, reported in the literature, map individual playing characteristics to reported entertainment...

  3. Diagnosis Aerobic Component of Operational Preparedness Skill Players

    Directory of Open Access Journals (Sweden)

    Vasylyuk Vasyl

    2017-01-01

    Full Text Available Considerable importance for the control system, selection and orientation of the players on the stage long-term preparation plays a selection of effective methods of testing the various components of functional fitness athlete for timely, objective information about the players. The use of reliable scientific methods of effective monitoring of the athlete contributes to the further improvement of skills, increase athletic achievements. The purpose of this article is to describe and summarize modern methods of diagnosis and development of aerobic component of operational preparedness players qualifications. This article describes methods that actively and effectively used in leading European football teams. Specifically Yo-Yo test, test Shuttle (beep-test, Bangsbo test, test Hoff-Helgerud, test Conconi, Wingate-test. These tests have a high level of reliability and security mechanisms for assessing aerobic power players.

  4. Research on Dietary Nutrition Supplement of Taekwondo Players

    Directory of Open Access Journals (Sweden)

    Shuqun Qu

    2014-10-01

    Full Text Available To comprehend the characteristics of Taekwondo and the problems lying in the nutrient and dietary structure of Taekwondo players through this study and then formulate a scientific and reasonable structure in nutrient and dietary for Taekwondo players, in order to improve their athletic ability in the meantime of improving their physical quality. To comprehend energy consumption characteristics of Taekwondo and current situation of nutrient and dietary structure of Taekwondo players through methods of literature collection and comparative research and then come up with a scientific and reasonable structure in nutrient and dietary. A reasonable nutrient and dietary structure can not only improve physical function and guarantee a normal internal metabolism of Taekwondo players, but also can effectively improve their athletic ability and improve their performance in competition.

  5. Hypoconnectivity and Hyperfrontality in Retired American Football Players

    Science.gov (United States)

    Hampshire, Adam; MacDonald, Alex; Owen, Adrian M.

    2013-10-01

    Recent research has raised concerns about the long-term neurological consequences of repetitive concussive and sub-concussive injuries in professional players of American Football. Despite this interest, the neural and psychological status of retired players remains unknown. Here, we evaluated the performances and brain activation patterns of retired National Football League players (NFL alumni) relative to controls using an fMRI-optimised neuropsychological test of executive function. Behaviourally, the NFL alumni showed only modest performance deficits on the executive task. By contrast, they showed pronounced hyperactivation and hypoconnectivity of the dorsolateral frontal and frontopolar cortices. Critically, abnormal frontal-lobe function was correlated with the number of times that NFL alumni reported having been removed from play after head injury and was evident in individual players. These results support the hypothesis that NFL alumni have a heightened probability of developing executive dysfunction and suggest that fMRI provides the most sensitive biomarker of the underlying neural abnormality.

  6. The Player, the Controller and the amazing Avatar

    DEFF Research Database (Denmark)

    Sandvik, Kjetil

    Playing computer games consists of an interplay between the player's body movements in the physical world and the agency of game characters in the game's virtual environment with the controller as a mediator remediating the movements of the player in physical space into the actions of the avatar...... and into its navigational operation in the synthetic space of the game world. Using N. Katherine Hayles approach to a ‘posthuman' understanding of the human body where "there are no essential differences or absolute demarcations between bodily existence and computer simulation, cybernetic mechanism...... hands and fingers and how these systems create a man-machine symbiotic game experience of agency and sense of control beyond the limits of the player's physical body. The Weemote thus becomes an extension of the player's body into the computer game world in a complex way: The Weemote not only controls...

  7. Extensive monitoring through multiple blood samples in professional soccer players

    DEFF Research Database (Denmark)

    Heisterberg, Mette F; Fahrenkrug, Jan; Krustrup, Peter

    2013-01-01

    ABSTRACT: The aim of this study was to make a comprehensive gathering of consecutive detailed blood samples from professional soccer players, and to analyze different blood parameters in relation to seasonal changes in training and match exposure.Blood samples were collected five times during a six...... months period and analyzed for 37 variables in 27 professional soccer players from the best Danish league. Additionally, players were tested for body composition, VO2max and physical performance by the Yo-Yo intermittent endurance sub-max test (IE2).Multiple variations in blood parameters occurred during...... of the season. Leucocytes decreased with increased physical training. Lymphocytes decreased at the end of the season. VO2max decreased towards the end of the season whereas no significant changes were observed in the IE2 test.The regular blood samples from elite soccer players reveal significant changes...

  8. Soccer players' fitting perception of different upper boot materials.

    Science.gov (United States)

    Olaso Melis, J C; Priego Quesada, J I; Lucas-Cuevas, A G; González García, J C; Puigcerver Palau, S

    2016-07-01

    The present study assessed the influence of upper boot materials on fitting perception. Twenty players tested three soccer boots only differing in the upper boot material (natural calf leather, natural kangaroo leather and synthetic leather). Players reported fitting perception and preference on specific foot areas using a perceived fitting scale. Ratings were averaged for every foot area. Repeated measures ANOVA was used to analyze the differences between boots. The kangaroo leather boots were perceived tighter and closer to the preferred fitting in general fitting, metatarsals area and instep area. The synthetic leather boots were perceived as the loosest and as the most distant boot from the preferred fitting in medial front area and instep area. In conclusion, the type of upper boot material influences the fitting perception of soccer players. The kangaroo leather was the material whose fitting was perceived closest to the players fitting preference.

  9. Development of speed qualities of skilled water-polo players

    Directory of Open Access Journals (Sweden)

    Ostrovsky M.V.

    2010-02-01

    Full Text Available Swimming preparation of water-polo players is the basic factor of victory of command. There are a few variants of development of speed swimming preparation. The effective pedagogical mean of stimulation of speed qualities is brief exercises at the end of employments after long aerobic work. The purpose of work is an improvement of method of speed preparation of skilled water-polo players. 26 skilled water-polo players (MS -14 and KMS - 12 took part in an experiment in age from 21 to 32 years. The results of correction of structure of training employment are in-process presented in micro cycle. They are directed on the improvement of speed qualities of water-polo players.

  10. Preferred Leadership Behaviours of Male and Female Badminton Players

    Directory of Open Access Journals (Sweden)

    Rajkumar S HARMA

    2015-06-01

    Full Text Available Pr eferences for specific coaching behaviours of male and female Badminton players were measured by the modified and revised Leadership Scale for Sport. Eighty two (Males=61, Females=21 badminton players were selected from amongst the players representing th eir respective university teams in East - zone Inter - university Badminton (Men/Women tournaments held at Bilaspur (CG. The present investigation noted the statistically significant differences among East - zone Inter - university level male as well as female B adminton player’s preferences for specific coaching behaviour. Differences were not observed between male and female badminton players in all the dimensions together of specific coaching behaviours of preferred leadership. It is recommended that coaches a lign their coaching style to meet the needs of their teams.

  11. How Players Lose Interest in Playing a Game

    DEFF Research Database (Denmark)

    Bauckhage, Christian; Kersting, Kristian; Sifa, Rafet

    2012-01-01

    Analyzing telemetry data of player behavior in computer games is a topic of increasing interest for industry and research, alike. When applied to game telemetry data, pattern recognition and statistical analysis provide valuable business intelligence tools for game development. An important problem...... introduce methods from random process theory into game data mining in order to draw inferences about player engagement. Given large samples (over 250,000 players) of behavioral telemetry data from five different action-adventure and shooter games, we extract information as to how long individual players...... have played these games and apply techniques from lifetime analysis to identify common patterns. In all five cases, we find that the Weibull distribution gives a good account of the statistics of total playing times. This implies that an average player’s interest in playing one of the games considered...

  12. A characterization of 2-player mechanisms for scheduling

    CERN Document Server

    Christodoulou, George; Vidali, Angelina

    2008-01-01

    We study the mechanism design problem of scheduling unrelated machines and we completely characterize the decisive truthful mechanisms for two players when the domain contains both positive and negative values. We show that the class of truthful mechanisms is very limited: A decisive truthful mechanism partitions the tasks into groups so that the tasks in each group are allocated independently of the other groups. Tasks in a group of size at least two are allocated by an affine minimizer and tasks in singleton groups by a task-independent mechanism. This characterization is about all truthful mechanisms, including those with unbounded approximation ratio. A direct consequence of this approach is that the approximation ratio of mechanisms for two players is 2, even for two tasks. In fact, it follows that for two players, VCG is the unique algorithm with optimal approximation 2. This characterization provides some support that any decisive truthful mechanism (for 3 or more players) partitions the tasks into gro...

  13. RIP3 induces apoptosis independent of pro-necrotic kinase activity

    Science.gov (United States)

    Mandal, Pratyusha; Berger, Scott B.; Pillay, Sirika; Moriwaki, Kenta; Huang, Chunzi; Guo, Hongyan; Lich, John D.; Finger, Joshua; Kasparcova, Viera; Votta, Bart; Ouellette, Michael; King, Bryan W.; Wisnoski, David; Lakdawala, Ami S.; DeMartino, Michael P.; Casillas, Linda N.; Haile, Pamela A.; Sehon, Clark A.; Marquis, Robert W.; Upton, Jason; Daley-Bauer, Lisa P.; Roback, Linda; Ramia, Nancy; Dovey, Cole M.; Carette, Jan E.; Chan, Francis; Bertin, John; Gough, Peter J.; Mocarski, Edward S.; Kaiser, William J.

    2015-01-01

    Summary Receptor interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease. Here, three selective small molecule compounds are shown to inhibit RIP3 kinase-dependent necroptosis, although their therapeutic value is undermined by a surprising, concentration-dependent induction of apoptosis. These compounds interact with RIP3 to activate caspase 8 (Casp8) via RHIM-driven recruitment of RIP1 (RIPK1) to assemble a Casp8-FADD-cFLIP complex completely independent of pro-necrotic kinase activities and MLKL. RIP3 kinase-dead D161N mutant induces spontaneous apoptosis independent of compound; whereas, D161G, D143N, and K51A mutants only trigger apoptosis when compound is present. Accordingly, RIP3-K51A mutant mice (Rip3K51A/K51A) are viable and fertile, in stark contrast to the perinatal lethality of Rip3D161N/D161N mice. RIP3 therefore holds both necroptosis and apoptosis in balance through a Ripoptosome-like platform. This work highlights a common mechanism unveiling RHIM-driven apoptosis by therapeutic or genetic perturbation of RIP3. PMID:25459880

  14. Ranking benchmarks of top 100 players in men's professional tennis.

    Science.gov (United States)

    Reid, Machar; Morris, Craig

    2013-01-01

    In men's professional tennis, players aspire to hold the top ranking position. On the way to the top spot, reaching the top 100 can be seen as a significant career milestone. National Federations undertake extensive efforts to assist their players to reach the top 100. However, objective data considering reasonable ranking yardsticks for top 100 success in men's professional tennis are lacking. Therefore, it is difficult for National Federations and those involved in player development to give empirical programming advice to young players. By taking a closer look at the ranking history of professional male tennis players, this article tries to provide those involved in player development a more objective basis for decision-making. The 100 names, countries, birthdates and ranking histories of the top 100 players listed in the Association of Tennis Professionals (ATP) at 31 December 2009 were recorded from websites in the public domain. Descriptive statistics were reported for the ranking milestones of interest. Results confirmed the merits of the International Tennis Federation's junior tour with 91% of the top 100 professionals earning a junior ranking, the mean peak of which was 94.1, s=148.9. On average, top 100 professionals achieved their best junior rankings and earned their first ATP point at similar ages, suggesting that players compete on both the junior and professional tours during their transition. Once professionally ranked, players took an average 4.5, s=2.1 years to reach the ATP top 100 at the mean age of 21.5, s=2.6 years, which contrasts with the mean current age of the top 100 of 26.8, s=3.2. The best professional rankings of players born in 1982 or earlier were positively related to the ages at which players earned their first ATP point and then entered the top 100, suggesting that the ages associated with these ranking milestones may have some forecasting potential. Future work should focus on the change in top 100 demographics over time as well

  15. Examining key design decisions involved in developing a serious game for child sexual abuse prevention

    Directory of Open Access Journals (Sweden)

    Colleen Joy Stieler-Hunt

    2014-02-01

    Full Text Available This paper presents a case study of the key decisions made in the design of Orbit, a child sexual abuse prevention computer game targeted at school students between 8 and 10 years of age. Key decisions include providing supported delivery for the target age group, featuring adults in the program, not over-sanitising game content, having a focus on building healthy self-concept of players, making the game engaging and relatable for all players and evaluating the program. This case study has implications for the design of Serious Games more generally, including that research should underpin game design decisions, game designers should consider ways of bridging the game to real life, the learning that arises from the game should go beyond rote-learning, designers should consider how the player can make the game-world their own and comprehensive evaluations of Serious Games should be undertaken.

  16. ARM 7 BASED MP3 PLAYER

    Directory of Open Access Journals (Sweden)

    Ashiq V Mehta

    2014-02-01

    Full Text Available MP3 is a patented encoding format for digital audio which uses a form of lossy data compression. It is a common audio format for consumer audio streaming or storage, as well as a de facto standard of digital audio compression for the transfer and playback of music on most digital audio players. Since the MPEG-1 Layer III encoding technology is nowadays widely used it might be interesting to gain knowledge of how this powerful compression/decompression scheme actually functions. The MPEG-1 Layer III is capable of reducing the bit rate with a factor of 12 without almost any audible degradation. Arm7 lpc2148 is arm7tdmi-s core board microcontroller that uses 16/32-bit 64 pin (lqfp microcontroller no.lpc2148 from Philips (nxp.The hardware system of lpc2148 includes the necessary devices within only one mcu has such as usb, adc, dac, timer/counter, pwm, capture, i2c, spi, uart, and etc.

  17. Upper extremity sensorimotor control among collegiate football players.

    Science.gov (United States)

    Laudner, Kevin G

    2012-03-01

    Injuries stemming from shoulder instability are very common among athletes participating in contact sports, such as football. Previous research has shown that increased laxity negatively affects the function of the sensorimotor system potentially leading to a pathological cycle of shoulder dysfunction. Currently, there are no data detailing such effects among football players. Therefore, the purpose of this study was to examine the differences in upper extremity sensorimotor control among football players compared with that of a control group. Forty-five collegiate football players and 70 male control subjects with no previous experience in contact sports participated. All the subjects had no recent history of upper extremity injury. Each subject performed three 30-second upper extremity balance trials on each arm. The balance trials were conducted in a single-arm push-up position with the test arm in the center of a force platform and the subjects' feet on a labile device. The trials were averaged, and the differences in radial area deviation between groups were analyzed using separate 1-way analyses of variance (p football players showed significantly more radial area deviation of the dominant (0.41 ± 1.23 cm2, p = 0.02) and nondominant arms (0.47 ± 1.63 cm2, p = 0.03) when compared with the control group. These results suggest that football players may have decreased sensorimotor control of the upper extremity compared with individuals with no contact sport experience. The decreased upper extremity sensorimotor control among the football players may be because of the frequent impacts accumulated during football participation. Football players may benefit from exercises that target the sensorimotor system. These findings may also be beneficial in the evaluation and treatment of various upper extremity injuries among football players.

  18. A Musculoskeletal Profile of Elite Female Soccer Players

    OpenAIRE

    Chiaia, Theresa A.; Maschi, Robert A.; Stuhr, Robyn M.; Rogers, Jennifer R.; Sheridan, Monique A.; Callahan, Lisa R.; Hannafin, Jo A.

    2009-01-01

    The purpose of this study is to identify lower-extremity (LE) musculoskeletal characteristics of elite female soccer players and to determine whether differences between dominant and nondominant extremities exist with respect to strength, flexibility, and range of motion. Physical data were collected from 26 female professional soccer players. Core control, hip and knee passive range of motion (PROM), LE flexibility, hip abductor strength, and dynamic functional alignment were assessed for ea...

  19. Different injury pattern in goalkeepers compared to field players

    DEFF Research Database (Denmark)

    Eirale, Cristiano; Tol, Johannes L; Whiteley, Rod;

    2014-01-01

    Goalkeepers have a specific physiological and biomechanical profile including hip loading with increased frontal plane kinetics and explosive side jumps. The aim of this study is to analyze the injury incidence in professional goalkeepers and to compare this with field players.......Goalkeepers have a specific physiological and biomechanical profile including hip loading with increased frontal plane kinetics and explosive side jumps. The aim of this study is to analyze the injury incidence in professional goalkeepers and to compare this with field players....

  20. Analysis of the Motor Activities of Professional Polish Soccer Players

    Directory of Open Access Journals (Sweden)

    Andrzejewski Marcin

    2016-12-01

    Full Text Available Introduction. The aims of the present study were to determine the activity profiles of a large sample of Polish Premier League soccer players during elite-standard soccer matches depending on their position on the pitch and the intensity range of physical activity. Material and methods. The study sample comprised 1,178 players in 5 outfield positions: external defenders (ED, n = 289, central defenders (CD, n = 307, central midfield players (CM, n = 327, external midfield players (EM, n = 152, and forwards (F, n = 103. Altogether, 81 Polish League games held during four domestic seasons (2010-2011, 2011-2012, 2012-2013, and 2013-2014 were used in the analysis. A semi-automatic computerised player tracking system (Amisco Pro®, version 1.0.2, Nice, France was applied to create the match activity profiles of the teams. Results. The results of statistical analysis revealed that the average total distance covered by all the players (n = 1,178 was 11,313 ± 852 m. With respect to the players’ position on the pitch, the central midfielders travelled the longest average distance (11,894 ± 765 m during the game. The longest distance was covered in the V1 intensity range (62%, followed by V2 (15%, V3 (10%, V4 (8%, V5 (3%, and V6 (2%. Conclusions. The objective of this study was to verify the differences among playing positions and to quantify the demands placed on elite Polish soccer players in each individual position during match play. While analysing elite-level match play in terms of the overall distance covered in different categories of intensity, we found a number of statistically significant differences between different playing positions. The data presented in this study can be regarded as norms for elite soccer players, serve for present and future comparison, and represent the scientific basis for developing position-specific conditioning/training protocols in soccer.

  1. Analyzing online game players: from materialism and motivation to attitude.

    Science.gov (United States)

    Chang, Ju-Hui; Zhang, Hongxia

    2008-12-01

    The online game market has been growing rapidly and has received an increasing amount of attention in recent years. The results of a survey conducted in China to explore online game players' attitude formation reveal that (a) the online game player's level of materialism positively influences the motivation for playing, (b) motivation positively influences attitude toward online games, and (c) motivation fully mediates the effects of materialism on attitude.

  2. The strategy of players on the European gas market

    Energy Technology Data Exchange (ETDEWEB)

    Lecarpentier, A

    2006-07-01

    One result of opening up the European gas market to competition has been to increase the number and diversity of the players involved, whether producers, suppliers or electric utilities. However, while the gas on offer is still controlled by a handful of market players given the increasing importance of state-owned companies from exporting countries outside Europe, the downstream gas sector continues to show a strong concentration of incumbent operators seeking a dominant position in the supply of gas. (author)

  3. An Analysis of Futsal Players' Self-Esteem Levels

    Science.gov (United States)

    Kocak, Mehmet

    2015-01-01

    The purpose of this study is to investigate the self-esteem levels of futsal players according to certain variables. The samples of the study constituted 119 females and 96 males; a total of 215 players with an average age of 21.57 ± 2.20 years. The research was carried out with the end of "Rosenberg self-esteem Scale" developed by…

  4. Progressive Kaizen The Key to Gaining a Global Competitive Advantage

    CERN Document Server

    Davis, John W

    2011-01-01

    All Kaizen is not one and the same. There are four distinctly different types, each with its own purpose and results. Companies that understand these differences harness Kaizen's ultimate power and influence and achieve amazing success in a global manufacturing environment. Companies must, however, restructure the major objectives of certain key players in the process and institute various management initiatives that drive Kaizen down to an individual job level. Written by recognized Lean Manufacturing professional John Davis, Progressive Kaizen: The Key to Gaining a Global Competitive Advanta

  5. [Eating habits of a group of professional volleyball players].

    Science.gov (United States)

    Gacek, Maria

    2011-01-01

    The aim of the research was an analysis of the eating habits of professional volleyball players according to their sex and age. The research has been carried out on a group of 210 men players and women players at the age of 13-25, representatives of sports clubs in Ostrołeka, Myślenice, Bydgoszcz and Warszawa. The research has revealed a limited realisation of rational diets by both men and women players. The most common mistakes made by them include a smaller number of meals during the day than recommended (especially among men), taking up training on empty stomach and insufficient frequency of consumption of dairy products, fish, vegetables and fruit. The research has also revealed excessive consumption of sweets, sweet sparkling drinks and fast food (mainly among men). The examined players to some extent only apply regular strategies of rehydration of their organisms. A high percentage of them do not pay attention to supplementation of liquids after an effort or they drink a lot of liquids at one time. The most frequently chosen drinks were mineral water and isotonic drinks. Supplementation was applied by a small percentage of the players, mainly men, who most often chose vitamins, Izostar, creatine, L-carnitine and HMB.

  6. Caffeine supplementation and reactive agility in elite youth soccer players.

    Science.gov (United States)

    Jordan, J Bradley; Korgaokar, Ajit; Farley, Richard S; Coons, John M; Caputo, Jennifer L

    2014-05-01

    This study examined the effects of caffeine supplementation (6 mg·kg-1) on performance of a reactive agility test (RAT) in 17 elite, male, youth (M = 14 y) soccer players. Using a double-blind, repeated-measures design, players completed 4 days of testing on the RAT after a standardized warm-up. On day 1, anthropometric measurements were taken and players were accommodated to the RAT. On day 2, baseline performance was established. Caffeine or placebo conditions were randomly assigned on day 3 and the condition was reversed on day 4. Players completed 3 randomized trials of the RAT on days 2, 3, and 4 with at least 1 trial to the players' dominant and nondominant sides. There were no significant differences among conditions in reaction time (RT) to the dominant side, heart rates at any point of measurement, or ratings of perceived exertion (RPE) after completion of the warm-up. Caffeine produced faster RT to the nondominant side (P = .041) and higher RPE at the conclusion of the RAT (P = .013). The effect on the total time (TT) to complete the agility test to the nondominant side approached significance (P = .051). Sprint time and TT to either side did not differ. Caffeine supplementation may provide ergogenic benefit to elite, male, youth soccer players.

  7. N-player quantum games in an EPR setting

    CERN Document Server

    Chappell, James M; Abbott, Derek

    2012-01-01

    The $N$-player quantum game is analyzed in the context of an Einstein-Podolsky-Rosen (EPR) experiment. In this setting, a player's strategies are not unitary transformations as in alternate quantum game-theoretic frameworks, but a classical choice between two directions along which spin or polarization measurements are made. The players' strategies thus remain identical to their strategies in the mixed-strategy version of the classical game. In the EPR setting the quantum game reduces itself to the corresponding classical game when the shared quantum state reaches zero entanglement. We find the relations for the probability distribution for $N$-qubit GHZ and W-type states, subject to general measurement directions, from which the expressions for the mixed Nash equilibrium and the payoffs are determined. Players' payoffs are then defined with linear functions so that common two-player games can be easily extended to the $N$-player case and permit analytic expressions for the Nash equilibrium. As a specific exa...

  8. Cavum Septum Pellucidum in Retired American Pro-Football Players.

    Science.gov (United States)

    Gardner, Raquel C; Hess, Christopher P; Brus-Ramer, Marcel; Possin, Katherine L; Cohn-Sheehy, Brendan I; Kramer, Joel H; Berger, Mitchel S; Yaffe, Kristine; Miller, Bruce; Rabinovici, Gil D

    2016-01-01

    Previous studies report that cavum septum pellucidum (CSP) is frequent among athletes with a history of repeated traumatic brain injury (TBI), such as boxers. Few studies of CSP in athletes, however, have assessed detailed features of the septum pellucidum in a case-control fashion. This is important because prevalence of CSP in the general population varies widely (2% to 85%) between studies. Further, rates of CSP among American pro-football players have not been described previously. We sought to characterize MRI features of the septum pellucidum in a series of retired pro-football players with a history of repeated concussive/subconcussive head traumas compared with controls. We retrospectively assessed retired American pro-football players presenting to our memory clinic with cognitive/behavioral symptoms in whom structural MRI was available with slice thickness ≤2 mm (n=17). Each player was matched to a memory clinic control patient with no history of TBI. Scans were interpreted by raters blinded to clinical information and TBI/football history, who measured CSP grade (0-absent, 1-equivocal, 2-mild, 3-moderate, 4-severe) and length according to a standard protocol. Sixteen of 17 (94%) players had a CSP graded ≥2 compared with 3 of 17 (18%) controls. CSP was significantly higher grade (pfootball players compared with patients without a history of TBI.

  9. Quantum key management

    Science.gov (United States)

    Hughes, Richard John; Thrasher, James Thomas; Nordholt, Jane Elizabeth

    2016-11-29

    Innovations for quantum key management harness quantum communications to form a cryptography system within a public key infrastructure framework. In example implementations, the quantum key management innovations combine quantum key distribution and a quantum identification protocol with a Merkle signature scheme (using Winternitz one-time digital signatures or other one-time digital signatures, and Merkle hash trees) to constitute a cryptography system. More generally, the quantum key management innovations combine quantum key distribution and a quantum identification protocol with a hash-based signature scheme. This provides a secure way to identify, authenticate, verify, and exchange secret cryptographic keys. Features of the quantum key management innovations further include secure enrollment of users with a registration authority, as well as credential checking and revocation with a certificate authority, where the registration authority and/or certificate authority can be part of the same system as a trusted authority for quantum key distribution.

  10. Dendritic Cell Apoptosis and the Pathogenesis of Dengue

    Directory of Open Access Journals (Sweden)

    Lysangela R. Alves

    2012-11-01

    Full Text Available Dengue viruses and other members of the Flaviviridae family are emerging human pathogens. Dengue is transmitted to humans by Aedes aegypti female mosquitoes. Following infection through the bite, cells of the hematopoietic lineage, like dendritic cells, are the first targets of dengue virus infection. Dendritic cells (DCs are key antigen presenting cells, sensing pathogens, processing and presenting the antigens to T lymphocytes, and triggering an adaptive immune response. Infection of DCs by dengue virus may induce apoptosis, impairing their ability to present antigens to T cells, and thereby contributing to dengue pathogenesis. This review focuses on general mechanisms by which dengue virus triggers apoptosis, and possible influence of DC-apoptosis on dengue disease severity.

  11. The effectiveness of shin guards used by football players.

    Science.gov (United States)

    Tatar, Yasar; Ramazanoglu, Nusret; Camliguney, Asiye Filiz; Saygi, Evrim Karadag; Cotuk, Hasan Birol

    2014-01-01

    In football, injuries from opponent contact occur commonly in the lower extremities. FIFA the world's governing body for football requires players to wear shin guards. The aim of this study was to compare the protective effectiveness of polypropylene based shin guards with custom-made carbon fiber ones. Three commercial polypropylene shin guards (Adidas Predator™, Adidas UCL™, and Nike Mercurial™) and two custom-made carbon fiber shin guards were examined. The experimental setup had the following parts: 1) A pendulum attached a load cell at the tip (CAS Corp., Korea) and a fixed prosthetic foot equipped with a cleat to simulate an attacker's foot. 2) An artificial tibia prepared by condensed foam and reinforced by carbon fibers protected with soft clothing. 3) A multifunctional sensor system (Tekscan Corp., F-Socket System, Turkey) to record the impact on the tibia. In the low impact force trials, only 2.79-9.63 % of the load was transmitted to the sensors. When comparing for mean force, peak force and impulse, both carbon fiber shin guards performed better than the commercial ones (Adidas Predator™, Adidas UCL™, and Nike Mercurial™) (p = 0.000). Based on these same parameters, the Nike Mercurial™ provided better protection than the Adidas Predator™ and the Adidas UCL™ (p = 0.000). In the high impact force trials, only 5.16-10.90 % of the load was transmitted to the sensors. For peak force and impulse, the carbon fiber shin guards provided better protection than all the others. Carbon fiber shin guards possess protective qualities superior to those of commercial polypropylene shin guards. Key PointsShin guards decrease the risk of serious injuries.Carbon shin guards provide sufficient protection against high impact forces.Commercially available Polypropylene based shin guards do not provide sufficient protection against high impact forces.

  12. Violent video game players and non-players differ on facial emotion recognition.

    Science.gov (United States)

    Diaz, Ruth L; Wong, Ulric; Hodgins, David C; Chiu, Carina G; Goghari, Vina M

    2016-01-01

    Violent video game playing has been associated with both positive and negative effects on cognition. We examined whether playing two or more hours of violent video games a day, compared to not playing video games, was associated with a different pattern of recognition of five facial emotions, while controlling for general perceptual and cognitive differences that might also occur. Undergraduate students were categorized as violent video game players (n = 83) or non-gamers (n = 69) and completed a facial recognition task, consisting of an emotion recognition condition and a control condition of gender recognition. Additionally, participants completed questionnaires assessing their video game and media consumption, aggression, and mood. Violent video game players recognized fearful faces both more accurately and quickly and disgusted faces less accurately than non-gamers. Desensitization to violence, constant exposure to fear and anxiety during game playing, and the habituation to unpleasant stimuli, are possible mechanisms that could explain these results. Future research should evaluate the effects of violent video game playing on emotion processing and social cognition more broadly.

  13. Teamwork the key to good patient care.

    Science.gov (United States)

    Baillie, Jonathan

    2013-05-01

    In a year when, with the inception of the new Clinical Commissioning Groups, the way that healthcare is procured and delivered will see radical changes, this month's HefmA 2013 National Conference & Exhibition will have as its theme, 'Many Players, One Goal: The Patient'. As HEJ editor, Jonathan Baillie reports, among the wide-ranging estates and facilities topics set for discussion will be 'Getting the patient environment right'; 'Dementia Building for the Future'; 'Waterborne Infections; Lessons Learned'; 'Incorporating lean thinking into design', and the key challenges faced by the estates and facilities sector. The keynote address, touching on a wide range of issues common to all large organisations, will be given by one of the best known 'women in football', and will also reflect particularly on the importance of teamwork.

  14. METABOLIC DEMANDS OF MATCH PERFORMANCE IN YOUNG SOCCER PLAYERS

    Directory of Open Access Journals (Sweden)

    Alper Aslan

    2012-03-01

    Full Text Available The aim of the present study was to determine metabolic responses, movement patterns and distance covered at running speeds corresponding to fixed blood lactate concentrations (FBLs in young soccer players during a match play. A further aim of the study was to evaluate the relationships between FBLs, maximal oxygen consumption (VO2max and distance covered during a game. A multistage field test was administered to 32 players to determine FBLs and VO2max. Blood lactate (LA, heart rate (HR and rate of perceived exertion (RPE responses were obtained from 36 players during tournament matches filmed using six fixed cameras. Images were transferred to a computer, for calibration and synchronization. In all players, values for LA and HR were higher and RPE lower during the 1st half compared to the 2nd half of the matches (p < 0.01. Players in forward positions had higher LA levels than defenders, but HR and RPE values were similar between playing positions. Total distance and distance covered in jogging, low-moderate-high intensity running and low intensity sprint were higher during the 1st half (p < 0.01. In the 1st half, players also ran longer distances at FBLs [p<0.01; average running speed at 2mmol·L-1 (FBL2: 3.32 ± 0.31m·s-1 and average running speed at 4mmol·L-1 (FBL4: 3.91 ± 0.25m·s-1]. There was a significant difference between playing positions in distance covered at different running speeds (p < 0.05. However, when distance covered was expressed as FBLs, the players ran similar distances. In addition, relationships between FBLs and total distance covered were significant (r = 0.482 to 0.570; p < 0.01. In conclusion, these findings demonstrated that young soccer players experienced higher internal load during the 1st half of a game compared to the 2nd half. Furthermore, although movement patterns of players differed between playing positions, all players experienced a similar physiological stress throughout the game. Finally, total

  15. Public Key Cryptography.

    Science.gov (United States)

    Tapson, Frank

    1996-01-01

    Describes public key cryptography, also known as RSA, which is a system using two keys, one used to put a message into cipher and another used to decipher the message. Presents examples using small prime numbers. (MKR)

  16. Key Management Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides a secure environment to research and develop advanced electronic key management and networked key distribution technologies for the Navy and DoD....

  17. Drosophila p53 controls Notch expression and balances apoptosis and proliferation.

    Science.gov (United States)

    Simón, Rocío; Aparicio, Ricardo; Housden, Ben E; Bray, Sarah; Busturia, Ana

    2014-10-01

    A balance between cell proliferation and apoptosis is important for normal development and tissue homeostasis. Under stress conditions, the conserved tumor suppressor and transcription factor Dp53 induces apoptosis to contribute to the maintenance of homeostasis. However, in some cases Dp53-induced apoptosis results in the proliferation of surrounding non-apoptotic cells. To gain insight into the Dp53 function in the control of apoptosis and proliferation, we studied the interaction between the Drosophila Dp53 and Notch genes. We present evidence that simultaneous reduction of Dp53 and Notch function synergistically increases the wing phenotype of Notch heterozygous mutant flies. Further, we found that a Notch cis-regulatory element is responsive to loss and gain of Dp53 function and that over-expression of Dp53 up-regulates Notch mRNA and protein expression. These findings suggest not only that Dp53 and Notch act together to control wing development but also indicate that Dp53 transcriptionally regulates Notch expression. Moreover, using Notch  gain and loss of function mutations we examined the relevance of Dp53 and Notch interactions in the process of Dp53-apoptosis induced proliferation. Results show that proliferation induced by Dp53 over-expression is dependent on Notch, thus identifying Notch as a new player in Dp53-induced proliferation. Interestingly, we found that Dp53-induced Notch activation and proliferation occurs even under conditions where apoptosis was inhibited. Our findings highlight the conservation between flies and vertebrates of the Dp53 and Notch cross-talk and suggest that Dp53 has a dual role regulating cell death and proliferation gene networks to control the homeostatic balance between apoptosis and proliferation.

  18. Isolation of key retinoid signalling and metabolic modules in invertebrates

    Directory of Open Access Journals (Sweden)

    Ana André

    2014-05-01

    Full Text Available Retinoids are a class of molecules related to vitamin A (Retinol that are required for regulation of critical chordate ndocrine-mediated process, such as embryonic development, reproduction, and vision. To maintain such physiological process, chordates have a complex mechanism to regulate the spatial and temporal distribution of retinoids that includes metabolic and signalling modules. Initially, retinoid modules were seen as a chordate novelty. However, emerging biochemical and genomic evidences have challenged this view, clearly pointing to a more basal ancestry than previously thought. However, for the majority of non-chordate invertebrate lineages a clearly characterization of the main enzymatic/molecular players is still missing. Despite limited, the available evidence supports the presence of biologically active retinoid pathways in invertebrates. In order to enhance our insights on retinoid biology, evolution, and its putative disruption by environmental chemicals, the isolation and functional characterization of key retinoid metabolic players in marine invertebrates has been carried out.

  19. Protooncogenes as mediators of apoptosis.

    Science.gov (United States)

    Teng, C S

    2000-01-01

    Apoptosis has been well established as a vital biological phenomenon that is important in the maintenance of cellular homeostasis. Three major protooncogene families and their encoded proteins function as mediators of apoptosis in various cell types and are the subject of this chapter. Protooncogenic proteins such as c-Myc/Max, c-Fos/c-Jun, and Bcl-2/Bax utilize a synergetic effect to enhance their roles in the pro- or antiapoptotic action. These family members activate and repress the expression of their target genes, control cell cycle progression, and execute programmed cell death. Repression or overproduction of these protooncogenic proteins induces apoptosis, which may vary as a result of either cell type specificity or the nature of the apoptotic stimuli. The proapoptotic and antiapoptotic proteins exert their effects in the membrane of cellular organelles. Here they generate cell-type-specific signals that activate the caspase family of proteases and their regulators for the execution of apoptosis.

  20. The Diet Quality of Competitive Adolescent Male Rugby Union Players with Energy Balance Estimated Using Different Physical Activity Coefficients

    Science.gov (United States)

    Burrows, Tracy; Harries, Simon K.; Williams, Rebecca L.; Lum, Cheryl; Callister, Robin

    2016-01-01

    Objectives: The aims of the current study were to comprehensively assess the dietary intakes and diet quality of a sample of Australian competitive adolescent rugby union players and compare these intakes with National and Sports Dietitians Association (SDA) Recommendations for adolescent athletes. A secondary aim investigated applying different physical activity level (PAL) coefficients to determine total energy expenditure (TEE) in order to more effectively evaluate the adequacy of energy intakes. Design: Cross-sectional. Methods: Anthropometrics and dietary intakes were assessed in 25 competitive adolescent male rugby union players (14 to 18 years old). Diet was assessed using the validated Australian Eating Survey (AES) food frequency questionnaire and diet quality was assessed through the Australian Recommended Food Score. Results: The median dietary intakes of participants met national recommendations for percent energy (% E) from carbohydrate, protein and total fat, but not carbohydrate intake when evaluated as g/day as proposed in SDA guidelines. Median intakes of fibre and micronutrients including calcium and iron also met national recommendations. Overall diet quality was classified as ‘good’ with a median diet quality score of 34 (out of a possible 73); however, there was a lack of variety within key food groups including carbohydrates and proteins. Non-core food consumption exceeded recommended levels at 38% of the daily total energy intake, with substantial contributions from takeaway foods and sweetened beverages. A PAL coefficient of 1.2–1.4 was found to best balance the energy intakes of these players in their pre-season. Conclusions: Adolescent rugby players met the percent energy recommendations for macronutrients and attained an overall ‘good’ diet quality score. However, it was identified that when compared to specific recommendations for athletes, carbohydrate intakes were below recommendations and these players in their pre

  1. Mechanisms for triceps surae injury in high performance front row rugby union players: a kinematic analysis of scrummaging drills.

    Science.gov (United States)

    Flavell, Carol A; Sayers, Mark G L; Gordon, Susan J; Lee, James B

    2013-01-01

    The front row of a rugby union scrum consists of three players. The loose head prop, hooker and tight head prop. The objective of this study was to determine if known biomechanical risk factors for triceps surae muscle injury are exhibited in the lower limb of front row players during contested scrummaging. Eleven high performance front row rugby union players were landmarked bilaterally at the posterior superior iliac spine (PSIS), greater trochanter, lateral femoral epicondyle, midline of the calcaneus above the plantar aspect of the heel, midline lower leg 5cm and 20cm proximal to the lateral malleolus, at the axis of subtalar joint, lateral malleolus, and head of the fifth metatarsal. Players were video recorded during a series of 2 on 1 live scrummaging drills. Biomechanical three dimensional analysis identified large angular displacements, and increased peak velocities and accelerations at the ankle joint during attacking scrummaging drill techniques when in the stance phase of gait. This places the triceps surae as increased risk of injury and provides valuable information for training staff regarding injury prevention and scrum training practices for front row players. Key pointsFront rowers exhibited patterns of single leg weight bearing, in a position of greater ankle plantar flexion and knee extension at toe off during scrummaging, which is a risk position for TS injury.Front rowers also exhibited greater acceleration at the ankle, knee, and hip joints, and greater changes in ankle ROM from toe strike to toe off during attacking scrum drills.These reported accelerations and joint displacements may be risk factors for TS injury, as the ankle is accelerating into plantar flexion at final push off and the muscle is shortening from an elongated state.

  2. The Diet Quality of Competitive Adolescent Male Rugby Union Players with Energy Balance Estimated Using Different Physical Activity Coefficients

    Directory of Open Access Journals (Sweden)

    Tracy Burrows

    2016-09-01

    Full Text Available Objectives: The aims of the current study were to comprehensively assess the dietary intakes and diet quality of a sample of Australian competitive adolescent rugby union players and compare these intakes with National and Sports Dietitians Association (SDA Recommendations for adolescent athletes. A secondary aim investigated applying different physical activity level (PAL coefficients to determine total energy expenditure (TEE in order to more effectively evaluate the adequacy of energy intakes. Design: Cross-sectional. Methods: Anthropometrics and dietary intakes were assessed in 25 competitive adolescent male rugby union players (14 to 18 years old. Diet was assessed using the validated Australian Eating Survey (AES food frequency questionnaire and diet quality was assessed through the Australian Recommended Food Score. Results: The median dietary intakes of participants met national recommendations for percent energy (% E from carbohydrate, protein and total fat, but not carbohydrate intake when evaluated as g/day as proposed in SDA guidelines. Median intakes of fibre and micronutrients including calcium and iron also met national recommendations. Overall diet quality was classified as ‘good’ with a median diet quality score of 34 (out of a possible 73; however, there was a lack of variety within key food groups including carbohydrates and proteins. Non-core food consumption exceeded recommended levels at 38% of the daily total energy intake, with substantial contributions from takeaway foods and sweetened beverages. A PAL coefficient of 1.2–1.4 was found to best balance the energy intakes of these players in their pre-season. Conclusions: Adolescent rugby players met the percent energy recommendations for macronutrients and attained an overall ‘good’ diet quality score. However, it was identified that when compared to specific recommendations for athletes, carbohydrate intakes were below recommendations and these players in their

  3. Monitoring for overreaching in rugby league players.

    Science.gov (United States)

    Coutts, Aaron J; Reaburn, Peter; Piva, Terrence J; Rowsell, Greg J

    2007-02-01

    The aim of this study was to identify indicators of non-functional overreaching (NFOR) in team sport athletes undertaking intensive training loads. Eighteen semi-professional rugby league players were randomly assigned into two pair matched groups. One group completed 6 weeks of normal training (NT) whilst the other group was deliberately overreached through intensified training (IT). Both groups then completed the same 7-day stepwise training load reduction taper. Multistage fitness test (MSFT) performance, VO2 (max), peak aerobic running velocity (V (max)), maximal heart rate, vertical jump, 10-s cycle sprint performance and body mass were measured pre- and post-training period and following the taper. Hormonal, haematological and immunological parameters were also measured pre-training and following weeks 2, 4 and 6 of training and post-taper. MANOVA for repeated measures with contrast analysis indicated that MSFT performance and VO2 (max) were significantly reduced in the IT group over time and condition, indicating that a state of overreaching was attained. However, the only biochemical measure that was significantly different between the IT and NT group was the glutamine to glutamate (Gln/Glu) ratio even though testosterone, testosterone to cortisol (T/C) ratio, plasma glutamate, and CK activity were significantly changed after training in both groups. Positive endurance and power performance changes were observed post-taper in the IT group confirming NFOR. These changes were associated with increases in the T/C ratio and the Gln/Glu ratio and decreases in plasma glutamate and CK activity. These results indicate that although there was no single reliable biochemical marker of NFOR in these athletes, the Gln/Glu ratio and MSFT test may be useful measures for monitoring responses to IT in team sport athletes.

  4. Quantum dense key distribution

    CERN Document Server

    Degiovanni, I P; Castelletto, S; Rastello, M L; Bovino, F A; Colla, A M; Castagnoli, G C

    2004-01-01

    This paper proposes a new protocol for quantum dense key distribution. This protocol embeds the benefits of a quantum dense coding and a quantum key distribution and is able to generate shared secret keys four times more efficiently than BB84 one. We hereinafter prove the security of this scheme against individual eavesdropping attacks, and we present preliminary experimental results, showing its feasibility.

  5. A novel firefly luciferase biosensor enhances the detection of apoptosis induced by ESAT-6 family proteins of Mycobacterium tuberculosis

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Junwei; Zhang, Huan; Fang, Liurong; Xi, Yongqiang; Zhou, Yanrong; Luo, Rui; Wang, Dang, E-mail: wangdang511@126.com; Xiao, Shaobo; Chen, Huanchun

    2014-10-03

    Highlights: • We developed a novel firefly luciferase based biosensor to detect apoptosis. • The novel biosensor 233-DnaE-DEVDG was reliable, sensitive and convenient. • 233-DnaE-DEVDG faithfully indicated ESAT-6 family proteins of Mycobacterium tuberculosis induced apoptosis. • EsxA, esxT and esxL in ESAT-6 family proteins induced apoptosis. • Activation of nuclear factor-κB (NF-κB) participated in esxT-induced apoptosis. - Abstract: The activation of caspase-3 is a key surrogate marker for detecting apoptosis. To quantitate caspase-3 activity, we constructed a biosensor comprising a recombinant firefly luciferase containing a caspase-3 cleavage site. When apoptosis was induced, caspase-3 cleavage of the biosensor activated firefly luciferase by a factor greater than 25. The assay conveniently detected apoptosis in real time, indicating that it will facilitate drug discovery. We screened ESAT-6 family proteins of Mycobacterium tuberculosis and found that esxA, esxT and esxL induced apoptosis. Further, activation of nuclear factor-κB (NF-κB) and the NF-κB-regulated genes encoding tumor necrosis factor-α (TNF-α) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) participated in esxT-induced apoptosis. We conclude that this assay is useful for high-throughput screening to identify and characterize proteins and drugs that regulate apoptosis.

  6. ANTHROPOMETRIC AND PHYSIOLOGICAL CHARACTERISTICS ON INDIAN INTERUNIVERSITY BASKETBALL PLAYERS

    Directory of Open Access Journals (Sweden)

    Shyamal Koley

    2010-08-01

    Full Text Available The purpose of this study was two-fold, firstly, to evaluate the anthropometric profile of Indian interuniversity basketball players and, secondly, to search the correlation of body mass index, % body fat, hand grip strength (right dominant and Vo2max,with other anthropometric characteristics studied. Eleven anthropometriccharacteristics, four body composition parameters, two physical and two physiological variables were measured on randomly selected 60 inter-university Indian basketball players (35 males and 25 females aged 18–25 years from Guru Nanak Dev University, Amritsar, Punjab, India with adequate controls (n = 102, 52 males and 50 females. The results indicated that male basketball players were taller (6.63% and heavier (7.31% and female basketball players were slightly taller (0.31% and lighter (3.74% than their control counterparts. One way analysis of variance showed significant (p ≤ .004 - .000 between group differences in all the variables (excepthip circumference between basketball players and controls. In basketball players, significantly positive correlations were found with BMI and other 12 variables, with percent body fat and 7 variables, with right hand grip strength and 12 variables and with Vo2max and other 9 variables, and significantly negative correlationswere found with BMI and other 1 variable (% lean body mass, with percent body fat and other 6 variables, with right hand grip strength and other 2 variables and with Vo2max with other 3 variables. The findings of the present study might be useful in future investigation on player selection, talent identification in the game of basketball and its training program development.

  7. Automatic acquisition of motion trajectories: tracking hockey players

    Science.gov (United States)

    Okuma, Kenji; Little, James J.; Lowe, David

    2003-12-01

    Computer systems that have the capability of analyzing complex and dynamic scenes play an essential role in video annotation. Scenes can be complex in such a way that there are many cluttered objects with different colors, shapes and sizes, and can be dynamic with multiple interacting moving objects and a constantly changing background. In reality, there are many scenes that are complex, dynamic, and challenging enough for computers to describe. These scenes include games of sports, air traffic, car traffic, street intersections, and cloud transformations. Our research is about the challenge of inventing a descriptive computer system that analyzes scenes of hockey games where multiple moving players interact with each other on a constantly moving background due to camera motions. Ultimately, such a computer system should be able to acquire reliable data by extracting the players" motion as their trajectories, querying them by analyzing the descriptive information of data, and predict the motions of some hockey players based on the result of the query. Among these three major aspects of the system, we primarily focus on visual information of the scenes, that is, how to automatically acquire motion trajectories of hockey players from video. More accurately, we automatically analyze the hockey scenes by estimating parameters (i.e., pan, tilt, and zoom) of the broadcast cameras, tracking hockey players in those scenes, and constructing a visual description of the data by displaying trajectories of those players. Many technical problems in vision such as fast and unpredictable players' motions and rapid camera motions make our challenge worth tackling. To the best of our knowledge, there have not been any automatic video annotation systems for hockey developed in the past. Although there are many obstacles to overcome, our efforts and accomplishments would hopefully establish the infrastructure of the automatic hockey annotation system and become a milestone for

  8. Prevalent morphometric vertebral fractures in professional male rugby players.

    Directory of Open Access Journals (Sweden)

    Karen Hind

    Full Text Available There is an ongoing concern about the risk of injury to the spine in professional rugby players. The objective of this study was to investigate the prevalence of vertebral fracture using vertebral fracture assessment (VFA dual energy X-ray absorptiometry (DXA imaging in professional male rugby players. Ninety five professional rugby league (n = 52 and union (n = 43 players (n = 95; age 25.9 (SD 4.3 years; BMI: 29.5 (SD 2.9 kg.m2 participated in the research. Each participant received one VFA, and one total body and lumbar spine DXA scan (GE Lunar iDXA. One hundred and twenty vertebral fractures were identified in over half of the sample by VFA. Seventy four were graded mild (grade 1, 40 moderate (grade 2 and 6 severe (grade 3. Multiple vertebral fractures (≥2 were found in 37 players (39%. There were no differences in prevalence between codes, or between forwards and backs (both 1.2 v 1.4; p>0.05. The most common sites of fracture were T8 (n = 23, T9 (n = 18 and T10 (n = 21. The mean (SD lumbar spine bone mineral density Z-score was 2.7 (1.3 indicating high player bone mass in comparison with age- and sex-matched norms. We observed a high number of vertebral fractures using DXA VFA in professional rugby players of both codes. The incidence, aetiology and consequences of vertebral fractures in professional rugby players are unclear, and warrant timely, prospective investigation.

  9. Development of repeated sprint ability in talented youth basketball players.

    Science.gov (United States)

    te Wierike, Sanne C M; de Jong, Mark C; Tromp, Eveline J Y; Vuijk, Pieter J; Lemmink, Koen A P M; Malina, Robert M; Elferink-Gemser, Marije T; Visscher, Chris

    2014-04-01

    Factors affecting repeated sprint ability (RSA) were evaluated in a mixed-longitudinal sample of 48 elite basketball players 14-19 years of age (16.1 ± 1.7 years). Players were observed on 6 occasions during the 2008-09 and 2009-10 seasons. Three following basketball-specific field tests were administered on each occasion: the shuttle sprint test for RSA, the vertical jump for lower body explosive strength (power), and the interval shuttle run test for interval endurance capacity. Height and weight were measured; body composition was estimated (percent fat, lean body mass). Multilevel modeling of RSA development curve was used with 32 players (16.0 ± 1.7 years) who had 2 or more observations. The 16 players (16.1 ± 1.8 years) measured on only 1 occasion were used as a control group to evaluate the appropriateness of the model. Age, lower body explosive strength, and interval endurance capacity significantly contributed to RSA (p ≤ 0.05). Repeated sprint ability improved with age from 14 to 17 years (p ≤ 0.05) and reached a plateau at 17-19 years. Predicted RSA did not significantly differ from measured RSA in the control group (p ≥ 0.05). The results suggest a potentially important role for the training of lower body explosive strength and interval endurance capacity in the development of RSA among youth basketball players. Age-specific reference values for RSA of youth players may assist basketball coaches in setting appropriate goals for individual players.

  10. LOCKS AND KEYS SERVICE

    CERN Multimedia

    Locks and Keys Service

    2002-01-01

    The Locks and Keys service (ST/FM) will move from building 55 to building 570 from the 2nd August to the 9th August 2002 included. During this period the service will be closed. Only in case of extreme urgency please call the 164550. Starting from Monday, 12th August, the Locks and Keys Service will continue to follow the activities related to office keys (keys and locks) and will provide the keys for furniture. The service is open from 8h30 to 12h00 and from 13h00 to 17h30. We remind you that your divisional correspondents can help you in the execution of the procedures. We thank you for your comprehension and we remain at your service to help you in solving all the matters related to keys for offices and furniture. Locks and Keys Service - ST Division - FM Group

  11. Apoptosis and oncogenesis: give and take in the BCL-2 family.

    Science.gov (United States)

    Llambi, Fabien; Green, Douglas R

    2011-02-01

    The mitochondrial pathway of apoptosis constitutes one of the main safeguards against tumorigenesis. The BCL-2 family includes the central players of this pathway that regulate cell fate through the control of mitochondrial outer membrane permeabilization (MOMP), and important progress has been made in understanding the dynamic interactions between pro-apoptotic and anti-apoptotic BCL-2 proteins. In particular, recent studies have delineated a stepwise model for the induction of MOMP. BCL-2 proteins are often dysregulated in cancer, leading to increased survival of abnormal cells; however, recent studies have paradoxically shown that apoptosis induction can under some circumstances drive tumor formation, perhaps by inducing compensatory proliferation under conditions of cellular stress. These observations underline the complexity of BCL-2 protein function in oncogenesis.

  12. Design of Emergent and Adaptive Virtual Players in a War RTS Game

    CERN Document Server

    Gutiérrez, José A García; Fernández-Leiva, Antonio J

    2012-01-01

    Basically, in (one-player) war Real Time Strategy (wRTS) games a human player controls, in real time, an army consisting of a number of soldiers and her aim is to destroy the opponent's assets where the opponent is a virtual (i.e., non-human player controlled) player that usually consists of a pre-programmed decision-making script. These scripts have usually associated some well-known problems (e.g., predictability, non-rationality, repetitive behaviors, and sensation of artificial stupidity among others). This paper describes a method for the automatic generation of virtual players that adapt to the player skills; this is done by building initially a model of the player behavior in real time during the game, and further evolving the virtual player via this model in-between two games. The paper also shows preliminary results obtained on a one player wRTS game constructed specifically for experimentation.

  13. THE EVALUATION OF SOME PHYSICAL AND PHYSIOLOGICAL CAHARACTERISTICS OF TURKISH AND FOREIGN NATIONAL BADMINTON TEAM PLAYERS

    Directory of Open Access Journals (Sweden)

    Serkan REVAN

    2007-12-01

    Full Text Available The aim of this study was to evaluate of some physical and physiological characteristics of Turkish and Foreign National Badminton Team Players.The study was participated by 50 players from Turkish team (12 males and 11 females, from foreign team (13 females and 14 males. Body mass index, audio and visual reaction times, anaerobic power, body fat percentage and somatotype components of the participants were determined.While visual right hand reaction times of Turkish Male Badminton Players were better than foreign players, other physical parameters were not found as statistically significant between male player groups. While visual left hand reaction times of Turkish Female Badminton Players were better and mesomorphy values were less than foreign players, in other physical parameters a statistically significant difference could not found between female player groups.As a result, physical and physiological characteristics of Turkish and foreign badminton players were similar.

  14. Molecular Mechanisms Regulating Ocular Apoptosis in Zebrafish gdf6a Mutants

    DEFF Research Database (Denmark)

    Pant, Sameer D.; March, Lindsey D.; Famulski, Jakub K.

    2013-01-01

    occurs 28 hours post fertilization (hpf) in gdf6a(-/-) mutants that is mediated independently of p53 by intrinsic mechanisms involving Bax proteins. Also, gdf6a(-/-) mutants exhibit markedly increased p38 MAP kinase activation that can be inhibited to significantly reduce retinal apoptosis. A reduction...... in retinal smad1 expression was also noted in gdf6a(-/-) mutants. CONCLUSIONS. gdf6a(-/-)-induced apoptosis is characterized by the involvement of intrinsic apoptotic pathways, p38 MAP kinases, and dysregulated smad expression. Modulation of key mediators can inhibit retinal apoptosis offering potential......PURPOSE. To characterize the molecular mechanisms underlying retinal apoptosis induced by loss of Gdf6, a TGF beta ligand. METHODS. The role of Gdf6 in regulating apoptosis was studied using a zebrafish gdf6a(-/-) mutant, which encodes a truncated, nonfunctional protein. To investigate whether...

  15. Game usability advancing the player experience

    CERN Document Server

    Isbister, Katherine

    2008-01-01

    I. What is usability and why should I care?A. Overview chapter Isbister and Schaffer (Editors)Introduces key concepts and positions book for primary audiences: game developers andstudents aspiring to work in game development. Addresses key concerns that developersmay have about adopting usability, and sets a broad road map of what is to come in thebook.B. Interview with Tobi Saulnier of 1st PlayableA discussion with the CEO of a small game studio about why and how she uses usabilitytechniques in her development.C. Interview with Don Norman of Nielsen Norman groupA discussion with one of the pr

  16. Iliopsoas and gluteal muscles are asymmetric in tennis players but not in soccer players.

    Directory of Open Access Journals (Sweden)

    Joaquin Sanchis-Moysi

    Full Text Available PURPOSE: To determine the volume and degree of asymmetry of iliopsoas (IL and gluteal muscles (GL in tennis and soccer players. METHODS: IL and GL volumes were determined using magnetic resonance imaging (MRI in male professional tennis (TP and soccer players (SP, and in non-active control subjects (CG (n = 8, 15 and 6, respectively. RESULTS: The dominant and non-dominant IL were hypertrophied in TP (24 and 36%, respectively, P<0.05 and SP (32 and 35%, respectively, P<0.05. In TP the asymmetric hypertrophy of IL (13% greater volume in the non-dominant than in the dominant IL, P<0.01 reversed the side-to-side relationship observed in CG (4% greater volume in the dominant than in the contralateral IL, P<0.01, whilst soccer players had similar volumes in both sides (P = 0.87. The degree of side-to-side asymmetry decreased linearly from the first lumbar disc to the pubic symphysis in TP (r = -0.97, P<0.001, SP (r = -0.85, P<0.01 and CG (r = -0.76, P<0.05. The slope of the relationship was lower in SP due to a greater hypertrophy of the proximal segments of the dominant IL. Soccer and CG had similar GL volumes in both sides (P = 0.11 and P = 0.19, for the dominant and contralateral GL, respectively. GL was asymmetrically hypertrophied in TP. The non-dominant GL volume was 20% greater in TP than in CG (P<0.05, whilst TP and CG had similar dominant GL volumes (P = 0.14. CONCLUSIONS: Tennis elicits an asymmetric hypertrophy of IL and reverses the normal dominant-to-non-dominant balance observed in non-active controls, while soccer is associated to a symmetric hypertrophy of IL. Gluteal muscles are asymmetrically hypertrophied in TP, while SP display a similar size to that observed in controls. It remains to be determined whether the different patterns of IL and GL hypertrophy may influence the risk of injury.

  17. Complexity of comparison of influence of players in simple games

    CERN Document Server

    Aziz, Haris

    2008-01-01

    Coalitional voting games appear in different forms in multi-agent systems, social choice and threshold logic. In this paper, the complexity of comparison of influence between players in coalitional voting games is characterized. The possible representations of simple games considered are simple games represented by winning coalitions, minimal winning coalitions, weighted voting game or a multiple weighted voting game. The influence of players is gauged from the viewpoint of basic player types, desirability relations and classical power indices such as Shapley-Shubik index, Banzhaf index, Holler index, Deegan-Packel index and Chow parameters. Among other results, it is shown that for a simple game represented by minimal winning coalitions, although it is easy to verify whether a player has zero or one voting power, computing the Banzhaf value of the player is #P-complete. Moreover, it is proved that multiple weighted voting games are the only representations for which it is NP-hard to verify whether the game i...

  18. Epidemiology of musculoskeletal injury in the tennis player.

    Science.gov (United States)

    Abrams, Geoffrey D; Renstrom, Per A; Safran, Marc R

    2012-06-01

    Tennis is a popular sport with tens of millions of players participating worldwide. This popularity was one factor leading to the reappearance of tennis as a medal sport at the 1988 Summer Olympics in Seoul, South Korea. The volume of play, combined with the physical demands of the sports, can lead to injuries of the musculoskeletal system. Overall, injury incidence and prevalence in tennis has been reported in a number of investigations. The sport creates specific demands on the musculoskeletal system, with acute injuries, such as ankle sprains, being more frequent in the lower extremity while chronic overuse injuries, such as lateral epicondylitis, are more common in the upper extremity in the recreational player and shoulder pain more common in the high-level player. This review discusses the epidemiology of injuries frequently experienced in tennis players and examines some of these injuries' correlation with the development of osteoarthritis. In addition, player-specific factors, such as age, sex, volume of play, skill level, racquet properties and grip positions as well as the effect of playing surface on the incidence and prevalence of injury is reported. Finally, recommendations on standardisation of future epidemiological studies on tennis injuries are made in order to be able to more easily compare results of future investigations.

  19. The movement characteristics of English Premiership rugby union players.

    Science.gov (United States)

    Cahill, Nicola; Lamb, Kevin; Worsfold, Paul; Headey, Roy; Murray, Stafford

    2013-01-01

    The purpose of this investigation was to quantify the movement characteristics of elite rugby union players during competitive play and identify whether position-related differences exist. Ninety-eight elite players from eight English Premiership Clubs were tracked using global positioning systems (GPS) during 44 competitive matches throughout the 2010/2011 season. Player positions were defined as: (1) backs or forwards; (2) front, second and back rows, scrum half, inside and outside backs; (3) 15 individual positions (numbers 1-15). Analysis revealed the game is predominantly played at low speeds with little distance covered 'sprinting' by either the backs (50 ± 76 m) or the forwards (37 ± 64 m). The backs travelled greater (P scrum half covered the greatest total distance during a match (7098 ± 778 m) and the front row the least (5158 ± 200 m). The back row covered the greatest distances at 'sprinting' speeds, particularly the number 8 position (77 m). These findings reflect notable differences in the movement characteristics displayed by elite rugby union players in specific positional roles, and reinforce the contemporary view that training programmes for such players ought to be structured with this in mind.

  20. Fitness Profiles of Elite Portuguese Rugby Union Players

    Directory of Open Access Journals (Sweden)

    Vaz Luís

    2014-07-01

    Full Text Available The aim of this study was to describe the fitness profiles of senior elite Portuguese rugby players. Forty-six senior Portuguese rugby players, classified as backs (n=22; age 26.2±2.8 and forwards (n=24; age 26.7±2.9 were assessed during physical testing sessions carried out for the Portuguese National rugby team. The body composition, maximum strength and anaerobic capacity of players are hypothesized to be important physical characteristics as successful performance in rugby is predicated on the ability to undertake skilled behaviours both quickly and whilst withstanding large forces when in contact situations. No absolute differences were found between the backs and forwards for the speed performance variables although positional differences were found across all speeds when assessed relative to body mass since the forwards were significantly heavier. Coaches and the management team can use this information for monitoring progressive improvements in the physiological capacities of rugby players. These physical characteristics of elite rugby players provide normative profiles for specific positions and should form the basis of developmental programmes for adolescents.

  1. Ιnjuries in greek amateur soccer players

    Directory of Open Access Journals (Sweden)

    GEORGIOS TSIGANOS

    2007-01-01

    Full Text Available The purpose of this study was to record retrospectivelythe epidemiology of injuries in amateur Greek soccer players. Three hundred and one (301 amateur soccer playersvoluntarily participated in the study. Participants answered aspecially-designed questionnaire that included questionsabout demographics, playing surface, division, position,hours of training plus participation, the use of stretching orprophylactic tape, the injury mechanism, the location andtype of injury. During the five years these soccer playerssustained a total of 1.745 injuries, that diagnosed by the orthopedist of the team. Most of injuries were strains (33%,overuse (27% and sprains (25%. The location of injurieswas the thigh (38 %, ankle (27% and knee (13%. Therewas a significant difference in the total number of injuriesamong soccer players with or without scoliosis (t=3.152,p. 0.05 and players that played on sand/dirt (gravel, whosustained more injuries than the players who played on artificial grass or on grass (t=3.413, p. 0.05. No differenceswere found in the other measurement parameters. The results of our study shows that spine deformities and groundsurfaces are the factors that causes more injuries in amateurGreek soccer players.

  2. A Discrete Evolutionary Model for Chess Players' Ratings

    CERN Document Server

    Fenner, Trevor; Loizou, George

    2011-01-01

    The Elo system for rating chess players, also used in other games and sports, was adopted by the World Chess Federation over four decades ago. Although not without controversy, it is accepted as generally reliable and provides a method for assessing players' strengths and ranking them in official tournaments. It is generally accepted that the distribution of players' rating data is approximately normal but, to date, no stochastic model of how the distribution might have arisen has been proposed. We propose such an evolutionary stochastic model, which models the arrival of players into the rating pool, the games they play against each other, and how the results of these games affect their ratings. Using a continuous approximation to the discrete model, we derive the distribution for players' ratings at time $t$ as a normal distribution, where the variance increases in time as a logarithmic function of $t$. We validate the model using published rating data from 2007 to 2010, showing that the parameters obtained...

  3. The impact of a sports vision training program in youth field hockey players.

    Science.gov (United States)

    Schwab, Sebastian; Memmert, Daniel

    2012-01-01

    The aim of this study was to investigate whether a sports vision training program improves the visual performance of youth male field hockey players, ages 12 to 16 years, after an intervention of six weeks compared to a control group with no specific sports vision training. The choice reaction time task at the D2 board (Learning Task I), the functional field of view task (Learning Task II) and the multiple object tracking (MOT) task (Transfer Task) were assessed before and after the intervention and again six weeks after the second test. Analyzes showed significant differences between the two groups for the choice reaction time task at the D2 board and the functional field of view task, with significant improvements for the intervention group and none for the control group. For the transfer task, we could not find statistically significant improvements for either group. The results of this study are discussed in terms of theoretical and practical implications. Key pointsPerceptual training with youth field hockey playersCan a sports vision training program improve the visual performance of youth male field hockey players, ages 12 to 16 years, after an intervention of six weeks compared to a control group with no specific sports vision training?The intervention was performed in the "VisuLab" as DynamicEye(®) SportsVision Training at the German Sport University Cologne.We ran a series of 3 two-factor univariate analysis of variance (ANOVA) with repeated measures on both within subject independent variables (group; measuring point) to examine the effects on central perception, peripheral perception and choice reaction time.The present study shows an improvement of certain visual abilities with the help of the sports vision training program.

  4. Hydration and Fluid Replacement Knowledge, Attitudes, Barriers, and Behaviors of NCAA Division 1 American Football Players.

    Science.gov (United States)

    Judge, Lawrence W; Kumley, Roberta F; Bellar, David M; Pike, Kim L; Pierson, Eric E; Weidner, Thomas; Pearson, David; Friesen, Carol A

    2016-11-01

    Judge, LW, Kumley, RF, Bellar, DM, Pike, KL, Pierson, EE, Weidner, T, Pearson, D, and Friesen, CA. Hydration and fluid replacement knowledge, attitudes, barriers, and behaviors of NCAA Division 1 American football players. J Strength Cond Res 30(11): 2972-2978, 2016-Hydration is an important part of athletic performance, and understanding athletes' hydration knowledge, attitudes, barriers, and behaviors is critical for sport practitioners. The aim of this study was to assess National Collegiate Athletic Association (NCAA) Division 1 (D1) American football players, with regard to hydration and fluid intake before, during, and after exercise, and to apply this assessment to their overall hydration practice. The sample consisted of 100 student-athletes from 2 different NCAA D1 universities, who participated in voluntary summer football conditioning. Participants completed a survey to identify the fluid and hydration knowledge, attitudes and behaviors, demographic data, primary football position, previous nutrition education, and barriers to adequate fluid consumption. The average Hydration Knowledge Score (HKS) for the participants in the present study was 11.8 ± 1.9 (69.4% correct), with scores ranging from 42 to 100% correct. Four key misunderstandings regarding hydration, specifically related to intervals of hydration habits among the study subjects, were revealed. Only 24% of the players reported drinking enough fluids before, during, immediately after, and 2 hours after practice. Generalized linear model analysis predicted the outcome variable HKS (χ = 28.001, p = 0.045), with nutrition education (Wald χ = 8.250, p = 0.041) and position on the football team (χ = 9.361, p = 0.025) being significant predictors. "Backs" (e.g., quarterbacks, running backs, and defensive backs) demonstrated significantly higher hydration knowledge than "Linemen" (p = 0.014). Findings indicated that if changes are not made to increase hydration awareness levels among football teams

  5. Adaptivity to Age, Gender, and Gaming Platform Topology in Physical Multi-Player Games

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Friðriksson, Rafn Vídalín; Björnsson, Davíð Þór

    2012-01-01

    In games where players are competing against each other, it can be of interest to ensure that all players are challenged according to their individual skills. In order to investigate such adaptivity to the individual player in physical multi-player games, we developed a game on modular interactive...... and adults, and between male and female players. Also, results show statistically significant differences in the game interactions between different physical set-ups of the modular interactive tiles, i.e. the interaction depended on the topology of the modular tiles set-up. Changing the physical set......-up of the physical game platform changes the interaction and performance of the players....

  6. Key Account Management

    OpenAIRE

    Dvořák, Dalibor

    2007-01-01

    This note tries to explain concept of key account management (KAM), factors leading to importance of this emerging concept, criteria to determine key accounts from customer base, benefits to both buyers and sellers agreeing to practice it, stages of KAM relationship, conditions under which power lies with buyer or seller, outlines risks faced by both the parties, key success factors, challenges faced in implementing this concept and relevance to infrastructure sector.

  7. Particle Swarm Optimization of Electricity Market Negotiating Players Portfolio

    DEFF Research Database (Denmark)

    Pinto, Tiago; Vale, Zita; Sousa, Tiago

    2014-01-01

    ’ research group has developed a multi-agent system: MASCEM (Multi- Agent System for Competitive Electricity Markets), which performs realistic simulations of the electricity markets. MASCEM is integrated with ALBidS (Adaptive Learning Strategic Bidding System) that works as a decision support system...... for market players. The ALBidS system allows MASCEM market negotiating players to take the best possible advantages from each market context. However, it is still necessary to adequately optimize the players’ portfolio investment. For this purpose, this paper proposes a market portfolio optimization method......, based on particle swarm optimization, which provides the best investment profile for a market player, considering different market opportunities (bilateral negotiation, market sessions, and operation in different markets) and the negotiation context such as the peak and off-peak periods of the day...

  8. Modeling the Semiotic Structure of Player-Characters

    DEFF Research Database (Denmark)

    Vella, Daniel

    2014-01-01

    When game studies has tackled the player-character, it has tended to do so by means of an opposition to the notion of the avatar, with the result that the ontological and semiotic nature of the character in itself has not been given due attention. This paper draws on understandings of character...... from the fields of narratology and literary theory to highlight the double-layered ontology of character as both a possible individual and as a semiotic construction. Uri Margolin’s narratological model of character signification is used as the basis for developing a semiotic-structural model...... of the player-character that addresses its specific medialities and formal nature – a task which is performed through illustrative close examinations of the player-characters in The Last of Us (Naughty Dog 2013) and Gone Home (The Fullbright Company 2013)....

  9. Psychosocial Stress and Sport Injuries in Tennis Players

    Directory of Open Access Journals (Sweden)

    Amador Blas Redondo

    2011-09-01

    Full Text Available The purpose of this study was to assess the perceived social stress and its relation to sports injuries in tennis players. Sixty-three male tennis players, with a mean age of 31.62 years (SD = 8.93, Sports Clubs belonging to the Province of Alicante (Spain completed instruments of psychosocial stress and injuries sustained during the previous year the assessment. The results indicate that life events experienced was related to some of the injuries suffered by players. Relationships were found between the degree of psychological stress experienced and the negative evaluation of this strain, the type (lesions on wrists, ankles and sprains, and severity of injuries (minor injuries.

  10. Two-player envy-free multi-cake division

    CERN Document Server

    Cloutier, John; Su, Francis Edward

    2009-01-01

    We introduce a generalized cake-cutting problem in which we seek to divide multiple cakes so that two players may get their most-preferred piece selections: a choice of one piece from each cake, allowing for the possibility of linked preferences over the cakes. For two players, we show that disjoint envy-free piece selections may not exist for two cakes cut into two pieces each, and they may not exist for three cakes cut into three pieces each. However, there do exist such divisions for two cakes cut into three pieces each, and for three cakes cut into four pieces each. The resulting allocations of pieces to players are Pareto-optimal with respect to the division. We use a generalization of Sperner's lemma on the polytope of divisions to locate solutions to our generalized cake-cutting problem.

  11. Somatotype of competitive youth soccer players from Brazil.

    Science.gov (United States)

    Fidelix, Yara Lucy; Berria, Juliane; Ferrari, Elisa Pinheiro; Ortiz, Jaelson Gonçalves; Cetolin, Tiago; Petroski, Edio Luiz

    2014-09-29

    The aim of this study was to identify the morphological configuration of youth athletes from professional soccer clubs and to verify their differences according to the tactical position on the field. Overall, 67 male players aged 15 to 17 years were evaluated. The examined anthropometric measurements included body mass, body height, skinfolds (triceps, subscapular, supraspinal and medial calf), girths (flexed and tensed arm and calf) and breadths (humerus and femur). For statistical purposes, analysis of variance and post hoc Bonferroni and Kruskal-Wallis tests were used. We concluded that goalkeepers were heavier and taller than center backs (p = 0.015 and p = 0.001), midfielders (p = 0.005 and p somatotype for defense, forward and goalkeeper positions was a balanced mesomorph. Midfield players showed ectomorphic-mesomorph characteristics. It was concluded that goalkeepers were characterized as being taller and heavier and that somatotype features of athletes were similar between positions, except for midfield players.

  12. Intermittent Testing and Training for High-Level Football Players

    DEFF Research Database (Denmark)

    Ingebrigtsen, Jørgen

    systematic differences between the playing positions can be detected. Lately, field tests have become more frequently used in football than the laboratory tests used in Study I. Study II therefore aims to assess the validity of one of them, the Yo-Yo Intermittent Recovery test level 2 (Yo-Yo IR2). Along...... with other field tests the Yo-Yo IR2 has become an important tool for monitoring the physical fitness of football players. However, the burden of testing, for players (physically and mentally) and the coaching staff (time consuming), is large and there is a probability that the tests may contain overlapping...... on the Yo-Yo IR2 test and other field- and laboratory tests of intermittent interval training performed as anaerobic speed-endurance production training is very limited for football players. Hence, this latter question is examined in Study IV.In Study I we find no differences in anthropometric...

  13. miR-326 Targets Antiapoptotic Bcl-xL and Mediates Apoptosis in Human Platelets

    OpenAIRE

    Shifang Yu; Huicong Huang; Gang Deng; Zuoting Xie; Yincai Ye; Ruide Guo; Xuejiao Cai; Junying Hong; Dingliang Qian; Xiangjing Zhou; Zhihua Tao; Bile Chen; Qiang Li

    2015-01-01

    Platelets play crucial roles in hemostasis, thrombosis, wound healing, inflammation, angiogenesis, and tumor metastases. Because they are anucleated blood cells, platelets lack nuclear DNA, but they do contain mitochondrial DNA, which plays a key role in regulating apoptosis. Recent evidence has suggested that miRNAs are also involved in regulating gene expression and apoptosis in platelets. Our previous study showed that the expression of miR-326 increased visibly when apheresis platelets we...

  14. The mitochondria-mediate apoptosis of Lepidopteran cells induced by azadirachtin.

    Directory of Open Access Journals (Sweden)

    Jingfei Huang

    Full Text Available Mitochondria have been shown to play an important role in apoptosis using mammalian cell lines. However, this seems not to be the case in Drosophila, an insect model organism; thus more in-depth studies of insect cell apoptosis are necessary. In the present study, mitochondrial involvement during azadirachtin- and camptothecin-induced apoptosis in Spodoptera frugiperda Sf9 cells (isolated from Spodoptera frugiperda pupal ovarian tissue was investigated. The results showed that both azadirachtin and camptothecin could induce apoptosis in Sf9 cells. Reactive oxygen species (ROS generation, activation of mitochondrial permeability transition pores (MPTPs and loss of mitochondrial membrane potential (MMP were observed very early during apoptosis and were followed subsequently by the release of cytochrome-c from the mitochondria. Furthermore, the results also revealed that the opening of MPTPs and the loss of MMP induced by azadirachtin could be significantly inhibited by the permeability transition pore (PTP inhibitor cyclosporin A (CsA, which was used to identify the key role of mitochondria in the apoptosis of Sf9 cells. However, in camptothecin-treated Sf9 cells, CsA could not suppress the opening of MPTPs and the loss of MMP when apoptosis was induced. The data from caspase-3 and caspase-9 activity assays and detection of apoptosis by morphological observation and flow cytometry also uncovered the different effect of CsA on the two botanical apoptosis inducers. Although different mechanisms of apoptosis induction exist, our study revealed that mitochondria play a crucial role in insect cell line apoptosis.

  15. Influence of fatigue on tackling technique in rugby league players.

    Science.gov (United States)

    Gabbett, Tim J

    2008-03-01

    This study investigated the influence of fatigue on tackling technique in rugby league players and determined the relationship between selected physiological capacities and fatigue-induced decrements in tackling technique. Eight rugby league players underwent a standardized one-on-one tackling drill in a 10-m grid. Players performed the one-on-one tackling drill before strenuous exercise and following game-specific repeated-effort exercise of progressively increasing intensities (corresponding to moderate, heavy, and very heavy intensity) in order to induce fatigue that was representative of match conditions. Video footage was taken from the rear, side, and front of the defending player. Tackling technique was objectively assessed using standardized technical criteria. In addition, all players underwent measurements of standard anthropometry (height, body mass, and sum of 7 skinfold measurements), speed (10-, 20-, and 40-m sprint), muscular power (vertical jump), agility (L run), and estimated maximal aerobic power (VO2max multistage fitness test). A progressive increase in total repeated-effort time, heart rate, blood lactate concentration, and ratings of perceived exertion occurred throughout the repeated-effort protocol, demonstrating a progressive increase in intensity and fatigue. Fatigue resulted in progressive reductions in tackling technique. Players with the best tackling technique in a nonfatigued state demonstrated the greatest decrement in tackling technique under fatigued conditions. In addition, a significant association was observed between estimated VO2max (r = -0.62) and agility (r = 0.68) and fatigue-induced decrements in tackling technique. From a practical perspective, these findings suggest that strength and conditioning programs designed to develop endurance, change of direction speed, and anticipation skills may reduce fatigue-induced decrements in tackling technique. Furthermore, any defensive drills designed to improve tackling technique

  16. Comparison of two aerobic field tests in young tennis players.

    Science.gov (United States)

    Fargeas-Gluck, Marie-Agnès; Léger, Luc A

    2012-11-01

    This study compares the maximal responses of a new aerobic tennis field test, the NAVTEN to a known aerobic field test, often used with young tennis players, that is, the continuous multistage 20-m shuttle run test (20-m SRT). The NAVTEN is an intermittent (1-minute/1-minute) multistage test with side-to-side displacements and ball hitting. Ten young elite tennis players aged 12.9 ± 0.3 (mean ± SD) randomly performed both tests and were continuously monitored for heart rate (HR) and oxygen uptake (V[Combining Dot Above]O2) using the Vmax ST (Sensormedics). The 20-m SRT and NAVTEN show similar HRpeak (202 ± 6.1 vs. 208 ± 9.5, respectively) and V[Combining Dot Above]O2peak (54.2 ± 5.9 vs. 54.9 ± 6.0 ml·kg·min). Pearson correlations between both tests were 0.88 and 0.92 for V[Combining Dot Above]O2peak and maximal speed, respectively. The NAVTEN yielded V[Combining Dot Above]O2peak values that are typical for active subjects of that age and are similar to the 20-m SRT supporting its use to measure aerobic fitness of young tennis players in specific and entertaining field conditions. The fact that two-thirds of the tennis players achieved a different ranking (±1 rank) with the NAVTEN and the 20-m SRT suggests that the NAVTEN may be more specific than the 20-m SRT to assess aerobic fitness of tennis players. From a practical point of view, the NAVTEN test is more specific and pedagogical for young tennis players even though both tests yield similar maximal values.

  17. HMGB1 mediates hyperglycaemia-induced cardiomyocyte apoptosis via ERK/Ets-1 signalling pathway.

    Science.gov (United States)

    Wang, Wen-Ke; Lu, Qing-Hua; Zhang, Jia-Ning; Wang, Ben; Liu, Xiang-Juan; An, Feng-Shuang; Qin, Wei-Dong; Chen, Xue-Ying; Dong, Wen-Qian; Zhang, Cheng; Zhang, Yun; Zhang, Ming-Xiang

    2014-11-01

    Apoptosis is a key event involved in diabetic cardiomyopathy. The expression of high mobility group box 1 protein (HMGB1) is up-regulated in diabetic mice. However, the molecular mechanism of high glucose (HG)-induced cardiomyocyte apoptosis remains obscure. We aimed to determine the role of HMGB1 in HG-induced apoptosis of cardiomyocytes. Treating neonatal primary cardiomyocytes with HG increased cell apoptosis, which was accompanied by elevated levels of HMGB1. Inhibition of HMGB1 by short-hairpin RNA significantly decreased HG-induced cell apoptosis by reducing caspase-3 activation and ratio of Bcl2-associated X protein to B-cell lymphoma/leukemia-2 (bax/bcl-2). Furthermore, HG activated E26 transformation-specific sequence-1 (Ets-1), and HMGB1 inhibition attenuated HG-induced activation of Ets-1 via extracellular signal-regulated kinase 1/2 (ERK1/2) signalling. In addition, inhibition of Ets-1 significantly decreased HG-induced cardiomyocyte apoptosis. Similar results were observed in streptozotocin-treated diabetic mice. Inhibition of HMGB1 by short-hairpin RNA markedly decreased myocardial cell apoptosis and activation of ERK and Ets-1 in diabetic mice. In conclusion, inhibition of HMGB1 may protect against hyperglycaemia-induced cardiomyocyte apoptosis by down-regulating ERK-dependent activation of Ets-1.

  18. Involvement of apoptosis in host-parasite interactions in the zebra mussel.

    Directory of Open Access Journals (Sweden)

    Laëtitia Minguez

    Full Text Available The question of whether cell death by apoptosis plays a biological function during infection is key to understanding host-parasite interactions. We investigated the involvement of apoptosis in several host-parasite systems, using zebra mussels Dreissena polymorpha as test organisms and their micro- and macroparasites. As a stress response associated with parasitism, heat shock proteins (Hsp can be induced. In this protein family, Hsp70 are known to be apoptosis inhibitors. Mussels were diagnosed for their respective infections by standard histological methods; apoptosis was detected using the TUNEL methods on paraffin sections and Hsp70 by immunohistochemistry on cryosections. Circulating hemocytes were the main cells observed in apoptosis whereas infected tissues displayed no or few apoptotic cells. Parasitism by intracellular bacteria Rickettsiales-like and the trematode Bucephalus polymorphus were associated with the inhibition of apoptosis whereas ciliates Ophryoglena spp. or the trematode Phyllodistomum folium did not involve significant differences in apoptosis. Even if some parasites were able to modulate apoptosis in zebra mussels, we did not see evidence of any involvement of Hsp70 on this mechanism.

  19. Akt is translocated to the mitochondria during etoposide-induced apoptosis of HeLa cells.

    Science.gov (United States)

    Park, Byoungduck; Je, Young-Tae; Chun, Kwang-Hoon

    2015-11-01

    Akt, or protein kinase B, is a key serine-threonine kinase, which exerts anti-apoptotic effects and promotes cell proliferation in response to various stimuli. Recently, however, it was demonstrated that Akt exhibits a proapoptotic role in certain contexts. During etoposide‑induced apoptosis of HeLa cells, Akt enhances the interaction of second mitochondria‑derived activator of caspases/direct IAP binding protein with low pI (Smac/DIABLO) and X‑linked inhibitor of apoptosis protein by phosphorylating Smac at serine 67, and thus promotes apoptosis. However, the detailed mechanisms underlying Akt regulation in etoposide‑mediated apoptosis remain to be determined. The present study investigated whether etoposide triggers the translocation of Akt into the mitochondria. It was found that Akt activity was increased and sustained during apoptosis triggered by etoposide in HeLa cells. During apoptosis, Akt was translocated from the cytoplasm into the mitochondria in a phosphoinositide 3‑kinase-dependent manner at the early and late stages of apoptosis. Concomitantly, the depletion of Akt in the nuclear fraction was observed after etoposide treatment from analysis of confocal microscopy. The results suggest that etoposide‑stimulated Akt is translocated into the mitochondria, thereby possibly enhancing its interaction with Smac and promoting apoptosis in HeLa cells. These results indicate that Akt may be a promising candidate for a pro-apoptotic approach in cancer treatment.

  20. Valgus Extension Overload in Baseball Players.

    Science.gov (United States)

    Paulino, Franklin E; Villacis, Diego C; Ahmad, Christopher S

    2016-01-01

    Repetitive throwing, such as in baseball pitching, applies massive stress on the elbow. This can often lead to a predictable constellation of elbow injuries, such as valgus extension overload syndrome (VEO). The following review of VEO provides an understanding of relevant anatomy, explanation of pathomechanics, key aspects to clinical evaluation, effective treatment options, and indications for surgery. In addition, we provide the senior author's (CSA) preferred arthroscopic technique for cases of VEO refractory to conservative management.

  1. Computing Sequential Equilibria for Two-Player Games

    DEFF Research Database (Denmark)

    Miltersen, Peter Bro; Sørensen, Troels Bjerre

    2006-01-01

    Koller, Megiddo and von Stengel showed how to efficiently compute minimax strategies for two-player extensive-form zero-sum games with imperfect information but perfect recall using linear programming and avoiding conversion to normal form. Koller and Pfeffer pointed out that the strategies...... a sequential equilibrium are computed. In particular, we show that a sequential equilibrium for a two-player zero-sum game with imperfect information but perfect recall can be found in polynomial time. In addition, the equilibrium we find is normal-form perfect. Our technique generalizes to general-sum games...

  2. Radiographic knee osteoarthritis in ex-elite table tennis players

    Directory of Open Access Journals (Sweden)

    Rajabi Reza

    2012-02-01

    Full Text Available Abstract Background Table tennis involves adoption of the semi-flexed knee and asymmetrical torsional trunk movements creating rotational torques on the knee joint which may predispose players to osteoarthritis (OA of the knee. This study aims to compare radiographic signs of knee OA and associated functional levels in ex-elite male table tennis players and control subjects. Methods Study participants were 22 ex-elite male table tennis players (mean age 56.64 ± 5.17 years with 10 years of involvement at the professional level and 22 non-athletic males (mean age 55.63 ± 4.08 years recruited from the general population. A set of three radiographs taken from each knee were evaluated by an experienced radiologist using the Kellgren and Lawrence (KL scale (0-4 to determine radiographic levels of OA severity. The intercondylar distance was taken as a measure of lower limb angulation. Participants also completed the pain, stiffness, and physical function categories of the Western Ontario and McMaster University Osteoarthritis Index (WOMAC 3.1 questionnaire. Results The results showed 78.3% of the ex-elite table tennis players and 36.3% of controls had varying signs of radiographic knee OA with a significant difference in the prevalence levels of definite radiographic OA (KL scale > 2 found between the two groups (P ≤ 0.001. Based on the WOMAC scores, 68.2% of the ex-elite table tennis players reported symptoms of knee pain compared with 27.3% of the controls (p = 0.02 though no significant differences were identified in the mean physical function or stiffness scores between the two groups. In terms of knee alignment, 73.7% of the ex-elite athletes and 32% of the control group had signs of altered lower limb alignment (genu varum (p = 0.01. Statistical differences were found in subjects categorized as having radiographic signs of OA and altered lower limb alignment (p = 0.03. Conclusions Ex-elite table tennis players were found to have increased

  3. Comparison of Ball-And-Racket Impact Force in Two-Handed Backhand Stroke Stances for Different-Skill-Level Tennis Players.

    Science.gov (United States)

    Lo, Kuo-Cheng; Hsieh, Yung-Chun

    2016-06-01

    This study compared the kinetic roles of the upper extremities in racket impact force generation between the open stance (OS) and square stance (SS) for tennis players with different skill levels in two-handed backhand strokes. Twelve male tennis players were divided into an advanced group (AG) (L3-L2 skill level) and intermediate group (IG) (L7-L6 skill level), and their data were used in a three-dimensional kinetic analysis. Their motions were captured using 21 reflective markers attached to anatomic landmarks for two-handed backhand stroke motion data collection. During the acceleration phase, significant differences were not observed between both stances, but they were observed between the groups with different skill levels for the force of the upper extremities (p = 0.027). The joint forces were significantly lower in the AG than in the IG. Players performing the SS had significantly larger pronation and supination of the wrist joint moment than those in the OS (p = 0.032) during the acceleration phase, irrespective of the playing level. Higher internal rotation moment after impact was observed at each joint, particularly among young intermediate tennis players, regardless of their stance. The AG demonstrated a higher joint force and moment at every joint compared with the IG at impact. Moreover, the AG demonstrated superior stroke efficiency and effectively reduced joint moment after impact and sports injury. Key pointsAdvanced players, regardless of open stance or square stance, have larger joint force and moment at each joint before ball impact resulting in better stroke efficiency and reduced chance of injury.Intermediate players, regardless of stance, have higher internal rotation moment at each joint instead of larger joint force as compared to advanced players before ball impact. The higher internal rotation moment will induce higher joint impact force which makes the player injury-prone.Young intermediate tennis players may want to avoid excessive

  4. The compact key

    NARCIS (Netherlands)

    NN,

    1966-01-01

    Here is given a sample of a new sort of identification key, recently developed by Dr. P. W. Leenhouts of the Rijksherbarium. Having to sort many specimens of Sapindaceae into genera, he became dissatisfied with the common dichotomous key, which too often does not work when the material is not comple

  5. Financial Key Ratios

    Directory of Open Access Journals (Sweden)

    Tănase Alin-Eliodor

    2014-08-01

    Full Text Available This article focuses on computing techniques starting from trial balance data regarding financial key ratios. There are presented activity, liquidity, solvency and profitability financial key ratios. It is presented a computing methodology in three steps based on a trial balance.

  6. Organizational and media stress among professional football players: testing an achievement goal theory model.

    Science.gov (United States)

    Kristiansen, E; Halvari, H; Roberts, G C

    2012-08-01

    The purpose of this study was to investigate media and coach-athlete stress experienced by professional football players and their relationship to motivational variables by testing an achievement goal theory (AGT) stress model. In order to do so, we developed scales specifically designed to assess media and coach-athlete stress. Eighty-two elite football players (M(age) =25.17 years, SD=5.19) completed a series of questionnaires. Correlations and bootstrapping were used as primary statistical analyses, supplemented by LISREL, to test the hypotheses. Results revealed that a mastery climate was directly and negatively associated with coach-athlete stress, while a performance climate was directly and positively associated with coach-athlete stress. In addition, an indirect positive path between the performance climate and media stress was revealed through ego orientation. These findings support some of the key postulates of AGT; a mastery climate reduces the perception of stress among athletes, and the converse is true for a performance climate. Coaches of elite footballers are advised to try to reduce the emphasis on performance criteria because of its stress-reducing effects.

  7. Jump Rope Training: Balance and Motor Coordination in Preadolescent Soccer Players.

    Science.gov (United States)

    Trecroci, Athos; Cavaggioni, Luca; Caccia, Riccardo; Alberti, Giampietro

    2015-12-01

    General physical practice and multidimensional exercises are essential elements that allow young athletes to enhance their coordinative traits, balance, and strength and power levels, which are linked to the learning soccer-specific skills. Jumping rope is a widely-used and non-specific practical method for the development of athletic conditioning, balance and coordination in several disciplines. Thus, the aim of this study was to investigate the effects of a short-term training protocol including jumping rope (JR) exercises on motor abilities and body balance in young soccer players. Twenty-four preadolescent soccer players were recruited and placed in two different groups. In the Experimental group (EG), children performed JR training at the beginning of the training session. The control group (CG), executed soccer specific drills. Harre circuit test (HCT) and Lower Quarter Y balance test (YBT-LQ) were selected to evaluate participant's motor ability (e.g. ability to perform rapidly a course with different physical tasks such as somersault and passages above/below obstacles ) and to assess unilateral dynamic lower limb balance after 8 weeks of training. Statistical analysis consisted of paired t-test and mixed analysis of variance scores to determine any significant interactions. Children who performed jumping rope exercises showed a significant decrease of 9% (p 0.05, ES = 0.05-0.2) from pre- to post-training. A training-by-group interaction was found for the composite score in both legs (p 0.14). Our findings demonstrated that JR practice within regular soccer training enhanced general motor coordination and balance in preadolescent soccer players. Therefore, the inclusion of JR practice within regular soccer training session should encouraged to improve children's motor skills. Key pointsPerforming jumping rope exercises within a regular soccer program can be an additional method to improve balance and motor coordination.The performance improvement in the

  8. Shuttle-run sprint training in hypoxia for youth elite soccer players: a pilot study.

    Science.gov (United States)

    Gatterer, Hannes; Philippe, Marc; Menz, Verena; Mosbach, Florian; Faulhaber, Martin; Burtscher, Martin

    2014-12-01

    The purposes of the present study were to investigate if a) shuttle-run sprint training performed in a normobaric hypoxia chamber of limited size (4.75x2.25m) is feasible, in terms of producing the same absolute training load, when compared to training in normoxia, and b) if such training improves the repeated sprint ability (RSA) and the Yo-Yo intermittent recovery (YYIR) test outcome in young elite soccer players. Players of an elite soccer training Centre (age: 15.3 ± 0.5 years, height: 1.73 ± 0.07 m, body mass: 62.6 ± 6.6 kg) were randomly assigned to a hypoxia or a normoxia training group. Within a 5-week period, players, who were not informed about the hypoxia intervention, performed at least 7 sessions of identical shuttle-run sprint training either in a normal training room (FiO2 = 20.95%) or in a hypoxic chamber (FiO2 = 14.8%; approximately 3300m), both equipped with the same floor. Each training session comprised 3 series of 5x10s back and forth sprints (4.5m) performed at maximal intensity. Recovery time between repetitions was 20s and between series 5min. Before and after the training period the RSA (6 x 40m shuttle sprint with 20 s rest between shuttles) and the YYIR test were performed. The size of the chamber did not restrict the training intensity of the sprint training (both groups performed approximately 8 shuttles during 10s). Training in hypoxia resulted in a lower fatigue slope which indicates better running speed maintenance during the RSA test (p = 0.024). YYIR performance increased over time (p = 0.045) without differences between groups (p > 0.05). This study showed that training intensity of the shuttle-run sprint training was not restricted in a hypoxic chamber of limited size which indicates that such training is feasible. Furthermore, hypoxia compared to normoxia training reduced the fatigue slope during the RSA test in youth soccer players. Key PointsShuttle-run sprint training is feasible in hypoxic chambers of limited size (i

  9. Ultra-Short-Term Heart Rate Variability is Sensitive to Training Effects in Team Sports Players.

    Science.gov (United States)

    Nakamura, Fabio Y; Flatt, Andrew A; Pereira, Lucas A; Ramirez-Campillo, Rodrigo; Loturco, Irineu; Esco, Michael R

    2015-09-01

    The aim of this study was to test the possibility of the ultra-short-term lnRMSSD (measured in 1-min post-1-min stabilization period) to detect training induced adaptations in futsal players. Twenty-four elite futsal players underwent HRV assessments pre- and post-three or four weeks preseason training. From the 10-min HRV recording period, lnRMSSD was analyzed in the following time segments: 1) from 0-5 min (i.e., stabilization period); 2) from 0-1 min; 1-2 min; 2-3 min; 3-4 min; 4-5 min and; 3) from 5-10 min (i.e., criterion period). The lnRMSSD was almost certainly higher (100/00/00) using the magnitude-based inference in all periods at the post- moment. The correlation between changes in ultra-short-term lnRMSSD (i.e., 0-1 min; 1-2 min; 2-3 min; 3-4 min; 4-5 min) and lnRMSSDCriterion ranged between 0.45-0.75, with the highest value (p = 0.75; 90% CI: 0.55 - 0.85) found between ultra-short-term lnRMDSSD at 1-2 min and lnRMSSDCriterion. In conclusion, lnRMSSD determined in a short period of 1-min is sensitive to training induced changes in futsal players (based on the very large correlation to the criterion measure), and can be used to track cardiac autonomic adaptations. Key pointsThe ultra-short-term (1 min) natural log of the root-mean-square difference of successive normal RR intervals (lnRMSSD) is sensitive to training effects in futsal playersThe ultra-short-term lnRMSSD may simplify the assessment of the cardiac autonomic changes in the field compared to the traditional and lengthier (10 min duration) analysisCoaches are encouraged to implement the ultra-short-term heart rate variability in their routines to monitor team sports athletes.

  10. Cardiomyocytic apoptosis and heart failure

    Institute of Scientific and Technical Information of China (English)

    Quanzhou Feng

    2008-01-01

    Heart failure is a major disease seriously threatening human health.Once left ventricular dysfunction develops,cardiac function usually deteriorates and progresses to congestive heart failure in several months or years even if no factors which accelerate the deterioration repeatedly exist.Mechanism through which cardiac function continually deteriorates is still unclear.Cardiomyocytic apoptosis can occur in acute stage of ischemic heart diseases and the compensated stage of cardiac dysfunction.In this review,we summarize recent advances in understanding the role of cardiomyocytic apoptosis in heart failure.

  11. ATTRIBUTIONS FOR SUCCESS AND FAILURE IN SPANISH TEAM SPORT PLAYERS

    Directory of Open Access Journals (Sweden)

    R. González-Boto

    2010-09-01

    Full Text Available

     

    ABSTRACT

    This study examined the role of ability, effort, luck and difficulty of the task in attributions for successful and unsuccessful performances made by Spanish team sport players, and determined if differences exist between athletes at different competition levels. Participants were 143 young men (soccer: N = 64; indoor soccer: N = 37; basketball: N = 42, ages 17 to 25 years (M = 20, SD = 5. Winners perceived ability and effort as the reasons behind their success while losers made attributions mainly to luck and the difficulty of the task. Ability and effort were in the three sports the reasons given for successful outcomes at various competition levels. Difficulty of the task was the factor rated higher by those who lost competing at a national level, while luck and effort were rated higher for those who lost competing at a regional and local level.
    KEY WORDS: attribution, team sports. competition levels

     

    RESUMEN

    En este estudio se analizaron el papel de la habilidad, el esfuerzo, la suerte y la dificultad de la tarea en las atribuciones de éxito y fracaso realizadas por practicantes españoles de deportes colectivos y se determinó si existían diferencias entre jugadores con distintos niveles de competición. Participaron 143 chicos (fútbol: N = 64; fútbol sala: N = 37; baloncesto: N = 42, con edades comprendidas entre 17 y 25 años (M = 20, SD = 5. Los ganadores consideraban la habilidad y el esfuerzo como las razones responsables de su éxito, mientras que los perdedores realizaban sus atribuciones principalmente a la suerte y a la dificultad de la tarea. En los tres deportes estudiados, la habilidad y el esfuerzo se

  12. First Days of Preseason Practice Pose Big Heat Risks for College Football Players

    Science.gov (United States)

    ... Preseason Practice Pose Big Heat Risks for College Football Players Coaches, trainers need to be aware of ... FRIDAY, Aug. 26, 2016 (HealthDay News) -- As college football players trade in their beach towels for helmets ...

  13. Postural stability decreases in elite young soccer players after a competitive soccer match

    DEFF Research Database (Denmark)

    Brito, João; Fontes, Ivo; Ribeiro, Fernando

    2012-01-01

    To investigate the effects of an official soccer match on postural stability in youth elite soccer players.......To investigate the effects of an official soccer match on postural stability in youth elite soccer players....

  14. The role of community in the development of elite handball and football players in Denmark

    DEFF Research Database (Denmark)

    Rossing, Niels Nygaard; Nielsen, André Bjørn; Elbe, A.-M.;

    2016-01-01

    The primary purpose of this study was to investigate the effect of the place of early development in a sample of Danish male elite and youth handball and football players. The sample included 366 handball and football players from the elite Danish league in the season 2011–2012 and a comparison...... sample of youth players under the age of 12 from 2003, including 147,221 football and 26,290 handball players. Odds ratio analysis showed that both population size and density significantly affected the proportional number of youth players per community and the odds of athletes reaching an elite level...... in football and handball. The odds for youth player registrations in both handball and football increased in rural in contrast to urban communities. However, elite football players primarily came from communities of high density (>1000 pop./km2), whereas elite handball players primarily came from less densely...

  15. EcoTRADE - a multi player network game of a tradable permit market for biodiversity credits

    CERN Document Server

    Hartig, Florian; Drechsler, Martin

    2008-01-01

    EcoTRADE is a multi player network game of a virtual biodiversity credit market. Each player controls the land use of a certain amount of parcels on a virtual landscape. The biodiversity credits of a particular parcel depend on neighboring parcels, which may be owned by other players. The game can be used to study the strategies of players in experiments or classroom games and also as a communication tool for stakeholders participating in credit markets that include spatially interdependent credits.

  16. Factors associated with deep tissue injury in male wheelchair basketball players of a Japanese national team

    Directory of Open Access Journals (Sweden)

    Hirotaka Mutsuzaki

    2014-04-01

    Full Text Available Maintenance of the sporting activity of elite athletes in adapted sports can be difficult if a secondary disorder, such as a pressure ulcer, occurs. Pressure ulcers result from deep tissue injuries by external pressure. The purpose of this study was to use ultrasonography to investigate deep tissue injuries in male wheelchair basketball players of a Japanese national team, and to determine factors associated with the injuries (e.g., body mass index, class of wheelchair basketball, underlying disease, length of athletic career, and whether use of wheelchair is primarily for playing basketball. Twenty male Japanese wheelchair basketball players on the national team for the 2012 London Paralympic Games (12 representative players and eight candidate representative players participated in this study. The sacral region and bilateral ischial regions in each athlete were examined by ultrasonography to detect low-echoic lesions indicative of deep tissue injuries. Nine (45% players had low-echoic lesions, which were detected in 10 of 60 areas. Eight lesions were detected in the sacral region and two lesions were detected in the ischial region. More players with spinal cord injury had low-echoic lesions [9 (69.2% of 13 players], compared to players with skeletal system disease [0 (0% of 7 players, p = 0.002]. Players who used a wheelchair in daily life were more likely to have low-echoic lesions [8 (66.74% of 12 players], compared to players who primarily used a wheelchair for playing basketball [1 (12.5% of 8 players, p = 0.010]. Deep tissue injuries were detected in 45% of male Japanese wheelchair basketball players on the national team. Players with spinal cord injury and players who used a wheelchair in daily life were more likely to have deep tissue injuries, particularly in the sacral region. The lesions were small, but a periodic medical check should be performed to maintain athletes' sporting life.

  17. The Effects of Interset Rest on Adaptation to 7 Weeks of Explosive Training in Young Soccer Players

    Science.gov (United States)

    Ramirez-Campillo, Rodrigo; Andrade, David C.; Álvarez, Cristian; Henríquez-Olguín, Carlos; Martínez, Cristian; Báez-SanMartín, Eduardo; Silva-Urra, Juan; Burgos, Carlos; Izquierdo, Mikel

    2014-01-01

    The aim of the study was to compare the effects of plyometric training using 30, 60, or 120 s of rest between sets on explosive adaptations in young soccer players. Four groups of athletes (age 10.4 ± 2.3 y; soccer experience 3.3 ± 1.5 y) were randomly formed: control (CG; n = 15), plyometric training with 30 s (G30; n = 13), 60 s (G60; n = 14), and 120 s (G120; n = 12) of rest between training sets. Before and after intervention players were measured in jump ability, 20-m sprint time, change of direction speed (CODS), and kicking performance. The training program was applied during 7 weeks, 2 sessions per week, for a total of 840 jumps. After intervention the G30, G60 and G120 groups showed a significant (p = 0.0001 – 0.04) and small to moderate effect size (ES) improvement in the countermovement jump (ES = 0.49; 0.58; 0.55), 20 cm drop jump reactive strength index (ES = 0.81; 0.89; 0.86), CODS (ES = -1.03; -0.87; -1.04), and kicking performance (ES = 0.39; 0.49; 0.43), with no differences between treatments. The study shows that 30, 60, and 120 s of rest between sets ensure similar significant and small to moderate ES improvement in jump, CODS, and kicking performance during high-intensity short-term explosive training in young male soccer players. Key points Replacing some soccer drills by low volume high-intensity plyometric training would be beneficial in jumping, change of direction speed, and kicking ability in young soccer players. A rest period of 30, 60 or 120 seconds between low-volume high-intensity plyometric sets would induce significant and similar explosive adaptations during a short-term training period in young soccer players. Data from this research can be helpful for soccer trainers in choosing efficient drills and characteristics of between sets recovery programs to enhance performances in young male soccer players. PMID:24790481

  18. The effects of interset rest on adaptation to 7 weeks of explosive training in young soccer players.

    Science.gov (United States)

    Ramirez-Campillo, Rodrigo; Andrade, David C; Alvarez, Cristian; Henríquez-Olguín, Carlos; Martínez, Cristian; Báez-Sanmartín, Eduardo; Silva-Urra, Juan; Burgos, Carlos; Izquierdo, Mikel

    2014-05-01

    The aim of the study was to compare the effects of plyometric training using 30, 60, or 120 s of rest between sets on explosive adaptations in young soccer players. Four groups of athletes (age 10.4 ± 2.3 y; soccer experience 3.3 ± 1.5 y) were randomly formed: control (CG; n = 15), plyometric training with 30 s (G30; n = 13), 60 s (G60; n = 14), and 120 s (G120; n = 12) of rest between training sets. Before and after intervention players were measured in jump ability, 20-m sprint time, change of direction speed (CODS), and kicking performance. The training program was applied during 7 weeks, 2 sessions per week, for a total of 840 jumps. After intervention the G30, G60 and G120 groups showed a significant (p = 0.0001 - 0.04) and small to moderate effect size (ES) improvement in the countermovement jump (ES = 0.49; 0.58; 0.55), 20 cm drop jump reactive strength index (ES = 0.81; 0.89; 0.86), CODS (ES = -1.03; -0.87; -1.04), and kicking performance (ES = 0.39; 0.49; 0.43), with no differences between treatments. The study shows that 30, 60, and 120 s of rest between sets ensure similar significant and small to moderate ES improvement in jump, CODS, and kicking performance during high-intensity short-term explosive training in young male soccer players. Key pointsReplacing some soccer drills by low volume high-intensity plyometric training would be beneficial in jumping, change of direction speed, and kicking ability in young soccer players.A rest period of 30, 60 or 120 seconds between low-volume high-intensity plyometric sets would induce significant and similar explosive adaptations during a short-term training period in young soccer players.Data from this research can be helpful for soccer trainers in choosing efficient drills and characteristics of between sets recovery programs to enhance performances in young male soccer players.

  19. Concussion Education for High School Football Players: A Pilot Study

    Science.gov (United States)

    Manasse-Cohick, Nancy J.; Shapley, Kathy L.

    2014-01-01

    This survey study compared high school football players' knowledge and attitudes about concussion before and after receiving concussion education. There were no significant changes in the Concussion Attitude Index. Results revealed a statistically significant difference in the athletes' scores for the Concussion Knowledge Index,…

  20. Role-player expectations regarding the education of nursing research

    Directory of Open Access Journals (Sweden)

    SCD Zeelie

    2003-09-01

    Full Text Available This article reports on role player expectations regarding the education of nursing research. The importance of the role player expectations are two-fold: firstly as a factor in the external environment influencing and guiding the formulation phase of the development of standards and secondly, due to the clear indications of problems regarding nursing research in the nursing profession in literature. The role player expectations were elicited using a qualitative, exploratory and contextual design. The role player population included nurse educators, nurses in managerial, clinical and research positions, students and the medical profession. The data was gathered using the naïve sketches and qualitative data analysis was done using Morse & Field’s approach (1996:103-107 in combination with Tesch’s data analysis approach as cited by Creswell (1994:154-156. Sixty initial categories were narrowed down to six final categories, which are the research learning programme, personnel, students, departmental policies, funding and support systems.

  1. Division IAA Football Players and Risk Factors for Metabolic Syndrome

    Science.gov (United States)

    Repovich, Wendy E. S.; Babcock, Garth J.

    2012-01-01

    The purpose of this study was to determine if body composition and blood pressure (BP), two markers for Metabolic Syndrome (MetS), were correlated in college football players. Height, weight, BMI, systolic (SBP) and Diastolic (DBP) blood pressure and body composition (three measures) were assessed in a Division IAA football team (N = 55). Data…

  2. Computing sequential equilibria for two-player games

    DEFF Research Database (Denmark)

    Miltersen, Peter Bro

    2006-01-01

    Koller, Megiddo and von Stengel showed how to efficiently compute minimax strategies for two-player extensive-form zero-sum games with imperfect information but perfect recall using linear programming and avoiding conversion to normal form. Their algorithm has been used by AI researchers for cons...

  3. Game Play Schemas: From Player Analysis to Adaptive Game Mechanics

    Directory of Open Access Journals (Sweden)

    Craig A. Lindley

    2008-01-01

    Full Text Available Schema theory provides a foundation for the analysis of game play patterns created by players during their interaction with a game. Schema models derived from the analysis of play provide a rich explanatory framework for the cognitive processes underlying game play, as well as detailed hypotheses for the hierarchical structure of pleasures and rewards motivating players. Game engagement is accounted for as a process of schema selection or development, while immersion is explained in terms of levels of attentional demand in schema execution. However, schemas may not only be used to describe play, but might be used actively as cognitive models within a game engine. Predesigned schema models are knowledge representations constituting anticipated or desired learned cognitive outcomes of play. Automated analysis of player schemas and comparison with predesigned target schemas can provide a foundation for a game engine adapting or tuning game mechanics to achieve specific effects of engagement, immersion, and cognitive skill acquisition by players. Hence, schema models may enhance the play experience as well as provide a foundation for achieving explicitly represented pedagogical or therapeutic functions of games.

  4. Body size and composition of National Football League players.

    Science.gov (United States)

    Kraemer, William J; Torine, Jon C; Silvestre, Ricardo; French, Duncan N; Ratamess, Nicholas A; Spiering, Barry A; Hatfield, Disa L; Vingren, Jakob L; Volek, Jeff S

    2005-08-01

    The purpose of this study was to present a profile of body size and composition of National Football League (NFL) players prior to the start of the regular season. Fifty-three members of the Indianapolis Colts professional football team were measured for height, body mass, and percentage body fat using the BOD POD air-displacement plethysmography system during summer camp of the 2003 football season. These data were categorized by position for comparison with previous studies of NFL football players. The relationships observed were as follows (= represents nonsignificant; > represents p Linebackers > Running Backs = Wide Receivers = Defensive Backs. Body Mass: Offensive Line = Defensive Line > Tight Ends = Linebackers > Running Backs = Quarterbacks/ Kickers/Punters > Wide Receivers = Defensive Backs. Percentage Body Fat: Offensive Line > Defensive Line > Quarterbacks/ Kickers/Punters = Linebackers = Tight Ends > Running Backs = Wide Receivers = Defensive Backs. Comparisons to teams in the 1970s indicate that body mass has increased only for offensive and defensive linemen; however, height and body fat among player positions have not dramatically changed. Furthermore, the body mass index is not an accurate measure or representation of body fat or obesity in NFL players. These data provide a basic template for size profiles and differences among various positions and allow comparisons with other studies for changes in the NFL over the past 3 decades.

  5. Not all players are equally motivated: The role of narcissism.

    Science.gov (United States)

    Roberts, Ross; Woodman, Tim; Lofthouse, Sian; Williams, Lucy

    2015-01-01

    Research on motivational climates consistently demonstrates that mastery-focused climates are associated with positive outcomes and ego-involving performance climates lead to maladaptive outcomes. However, the role of personality within such a framework has been largely ignored. To redress this imbalance, we examined the potential role of narcissism in moderating the effects of different motivational climates on leader-inspired extra effort in training. Training is where rugby players spend most of their rugby time and we were keen to examine the combination of personality and climate that might maximise the yield of such training environments. Female rugby players (n = 126) from 15 clubs completed measures of narcissism, motivational climate and effort. Moderated regression analyses revealed that narcissism moderated the relationship between motivational climate and effort. Increases in either performance or mastery climates were associated with increases in effort for narcissists; no such relationship was revealed for low narcissists. The findings demonstrate the importance of considering personality within rugby training environments, as it is clear that not every player will respond the same way to specific training conditions. Coaches who understand this and are able to tailor individualised motivational climates will likely gain the greatest benefits from their different players.

  6. Organizational Gameplay: The Player as Designer of Character Organizations

    Directory of Open Access Journals (Sweden)

    Luciano R. Coutinho

    2015-01-01

    Full Text Available Looking at the ways in which players interact with computer games (the gameplays, we perceive predominance of character-centered and/or microcontrolled modes of interaction. Despite being well established, these gameplays tend to structure the games in terms of challenges to be fulfilled on an individual basis, or by thinking collectively but having to microcontrol several characters at the same time. From this observation, the paper presents a complementary gameplay in which the player is urged to face collective challenges by designing character organizations. The basic idea is to make the player structure and control group of characters by defining organizational specifications (i.e., definitions of roles, collective strategies, and social norms. During the game, commanded by the player, artificial agents are then instantiated to play the roles and to follow the strategies and norms as defined in the organizational specification. To turn the idea into practice, the paper proposes an abstract architecture comprising three components or layers. This architecture is materialized in a proof of concept prototype that combines the Minecraft game server, JADE agent platform, and MOISE+ organizational model. Variations and possibilities are discussed and the proposal is compared to related work in the literature.

  7. Hand Grip Strength Vs. Sprint Effectiveness in Amputee Soccer Players

    Directory of Open Access Journals (Sweden)

    Wieczorek Marta

    2015-12-01

    Full Text Available Amputee soccer is one of the types of soccer designed for the disabled, especially those who have undergone amputations, as well as those with extremity dysfunction. The objective of the study was to find the relationship between hand grip strength and sprint time in amputee soccer players. Thirteen field amputee soccer players participated in the study. A SAEHAN hydraulic hand dynamometer manufactured by Jamar was used for hand grip strength measurements. The sprint running test was conducted over a distance of 30 m. The Fusion Smart Speed System was employed for running time measurements. No statistically significant relationships were found between hand grip strength of the left or right hand, and sprint times over 1, 5, 10, 15, 20, 25 and 30 m. Analysis of the running velocity curve of the subjects showed an interesting profile characterized by a 15 meter-long acceleration phase and a significant velocity increase over a distance of 20 – 25 m. The study suggests that there is no relationship between hand grip strength and sprint effectiveness in amputee soccer players. The specificity of locomotion with the use of elbow crutches among elite Polish amputee soccer players probably accounts for the profile of the sprint velocity curve. Extension of the acceleration phase in the sprint run and a velocity increase in the subsequent part of the run were observed.

  8. Deploying music characteristics for an affective music player

    NARCIS (Netherlands)

    Zwaag, van der Marjolein D.; Westerink, Joyce H.D.M.; Broek, van den Egon L.; Cohn, Jeffrey; Nijholt, Anton; Pantic, Maja

    2009-01-01

    This paper describes work toward an affective music player (AMP), which is able to direct affect to a goal state by selecting music. Repeatedly, music has been shown to modulate affect; however, precise guidelines for the use of music characteristics in an AMP have not been defined. To explore these

  9. meIRL-BC: Predicting Player Positions in Video Games

    NARCIS (Netherlands)

    I. Becht; S. Bakkes

    2014-01-01

    In this paper we demonstrate how behaviour-classification models can improve player position prediction for video game AI. To this end, we propose a novel method named meIRL-BC, which (1) uses maximum-entropy Inverse Reinforcement Learning for the creation of position prediction models [15], and (2)

  10. Foot posture and patellar tendon pain among adult volleyball players

    NARCIS (Netherlands)

    Groot, R. de; Malliaras, P.; Munteanu, S.; Payne, C.; Morrissey, D.; Maffulli, N.

    2012-01-01

    OBJECTIVE: We hypothesized that individuals with a normal foot posture would be less likely to experience patellar tendon pain and pathology than those with a pronated or supinated foot. DESIGN: Observational study. SETTING: Field-based study among competing athletes. PARTICIPANTS: Volleyball player

  11. Tales of the Unexpected: Coping among Female Collegiate Volleyball Players

    Science.gov (United States)

    Holt, Nicholas L.; Berg, Kylie-Joy; Tamminen, Katherine A.

    2007-01-01

    The purpose of this study was to examine patterns of appraisal, coping, and coping effectiveness in sport. Ten players from a collegiate female volleyball team were interviewed on two occasions, first in the week before a provincial final playoff tournament and in the week following the tournament. Data were transcribed verbatim and subjected to…

  12. Long-term training adaptations in elite male volleyball players.

    Science.gov (United States)

    Sheppard, Jeremy M; Newton, Robert U

    2012-08-01

    Several investigations have demonstrated differences in anthropometry, jump performance, and strength variables between developmental and elite-level volleyball players. However, within the elite level of play, the magnitude of change that can occur with training is unclear. The purpose of this investigation was to examine the anthropometric, vertical jump, and strength quality changes over 2 years in a group of national team volleyball players. Fourteen national team volleyball players (age, 23.0 ± 4.1 years; height, 1.98 ± 0.07 m; weight, 91.7 ± 7.9 kg) began and completed this study. Participants had all played international matches (representing Australia) before the examination time period and continued to do so during the international season. Anthropometry (stature, mass, and sum of 7 skinfolds), vertical jump measures (countermovement vertical jump; depth jump from 0.35 m, DJ; spike jump, SPJ, all including arm swing), and lower-body power (jump squat at body mass, and jump squat + 50% body weight, JS50) measures were tested before and at the conclusion of the investigation period. Significant (p 0.70) in the sum of 7 skinfolds reduction, SPJ, and leg extensor power. This study has demonstrated that elite male volleyball players can improve leanness and power, which contribute to improvements in vertical jump.

  13. Foot Posture and Patellar Tendon Pain Among Adult Volleyball Players

    NARCIS (Netherlands)

    de Groot, Reinier; Malliaras, Peter; Munteanu, Shannon; Payne, Craig; Morrissey, Dylan; Maffulli, Nicola

    2012-01-01

    Objective: We hypothesized that individuals with a normal foot posture would be less likely to experience patellar tendon pain and pathology than those with a pronated or supinated foot. Design: Observational study. Setting: Field-based study among competing athletes. Participants: Volleyball player

  14. Older Amateur Keyboard Players Learning for Self-Fulfilment

    Science.gov (United States)

    Taylor, Angela

    2011-01-01

    This article investigates self-reported music learning experiences of 21 older amateur pianists and electronic keyboard players. Significant changes in their lives and the encouragement of friends were catalysts for returning to or taking up a keyboard instrument as an adult, although not all returners had positive memories of learning a keyboard…

  15. Octonionization of three player, two strategy maximally entangled quantum games

    OpenAIRE

    Ahmed, Aden; Bleiler, Steve; Khan, Faisal Shah

    2008-01-01

    We develop an octonionic representation of the payoff function for three player, two strategy, maximally entangled quantum games in order to obtain computationally friendly version of this function. This computational capability is then exploited to analyze and potentially classify the Nash equilibria in the quantum games.

  16. Body composition and nutritional profile of male adolescent tennis players.

    Science.gov (United States)

    Juzwiak, Claudia R; Amancio, Olga M S; Vitalle, Maria S S; Pinheiro, Marcelo M; Szejnfeld, Vera L

    2008-09-01

    In this cross-sectional study, we evaluated the body composition and dietary intake of 44 adolescent tennis players. After being divided into two groups (age 10-13 years and age 14-18), the players had their weight, height, and sexual maturation assessed. Dual-energy X-ray absorptiometry was used to assess body composition. Food intake was obtained from a non-consecutive 4-day food record. The data were analysed using the Virtual Nutri v.1.0 software and compared with the present recommendations for adolescent athletes or dietary reference intakes. Body mass index and body fat for tennis practice were adequate for 89% and 71% of the tennis players respectively, regardless of age group. A calorie deficit greater than 10% of energy expenditure was observed in 32% of the sample. Fifty percent of the athletes consumed carbohydrates in accordance with recommended values. Protein and lipid intakes were above recommended values, while fibre, calcium, potassium, magnesium, and folic acid intakes were below recommendation for 98%, 80%, 100%, 100%, and 98% of the tennis players respectively. The observed nutritional deficiencies represent an additional barrier for adolescents engaged in competitive sports to achieve an optimum nutrition to maintain growth, health, and performance.

  17. Personality and Injury Risk Among ‎Professional Hockey Players

    Directory of Open Access Journals (Sweden)

    David C. Schwebel

    2009-07-01

    Full Text Available Background: Although much is known about risk for athletic injury, research on the roles of individual differences in personality and temperament on athletic injury has lagged. We hypothesized that professional athletes with high sensation-seeking and extraversion scores, and with low effortful control scores, would experience more injuries over the course of a season, would have more severe injuries, and would miss more total days of play. Methods: Prospective design with questionnaire report at time one and injury tracking throughout an 18-week athletic season. Setting: Professional hockey team in the United States. Participants: Eighteen professional hockey players (ages 21-33. Measurements: Players completed self-report personality (Sensation-Seeking Scale, Form V and temperament (the Adult Temperament Questionnaire measures. Quantity and severity of injury, as well as playing time missed, were tracked for 18 weeks. Results: On average, players experienced almost 6 injuries causing a loss of 10 playing days through the season. Those players scoring high on Boredom Susceptibility and Total Sensation-Seeking incurred more total injuries. Those scoring high on temperamental neutral perceptual sensitivity suffered more severe injuries. Conclusions: Athletes who suffered more injuries reported a preference for stimulating environments and boredom with non-stimulating environments. Injury severity was not correlated with sensation-seeking but was related to temperamental perceptual sensitivity. Implications for identification of injury-prone athletes, pre-injury training, and post-injury treatment are discussed.

  18. Active Player Modeling in the Iterated Prisoner's Dilemma.

    Science.gov (United States)

    Park, Hyunsoo; Kim, Kyung-Joong

    2016-01-01

    The iterated prisoner's dilemma (IPD) is well known within the domain of game theory. Although it is relatively simple, it can also elucidate important problems related to cooperation and trust. Generally, players can predict their opponents' actions when they are able to build a precise model of their behavior based on their game playing experience. However, it is difficult to make such predictions based on a limited number of games. The creation of a precise model requires the use of not only an appropriate learning algorithm and framework but also a good dataset. Active learning approaches have recently been introduced to machine learning communities. The approach can usually produce informative datasets with relatively little effort. Therefore, we have proposed an active modeling technique to predict the behavior of IPD players. The proposed method can model the opponent player's behavior while taking advantage of interactive game environments. This experiment used twelve representative types of players as opponents, and an observer used an active modeling algorithm to model these opponents. This observer actively collected data and modeled the opponent's behavior online. Most of our data showed that the observer was able to build, through direct actions, a more accurate model of an opponent's behavior than when the data were collected through random actions.

  19. Reciprocity on the hardwood: passing patterns among professional basketball players.

    Science.gov (United States)

    Willer, Robb; Sharkey, Amanda; Frey, Seth

    2012-01-01

    Past theory and research view reciprocal resource sharing as a fundamental building block of human societies. Most studies of reciprocity dynamics have focused on trading among individuals in laboratory settings. But if motivations to engage in these patterns of resource sharing are powerful, then we should observe forms of reciprocity even in highly structured group environments in which reciprocity does not clearly serve individual or group interests. To this end, we investigated whether patterns of reciprocity might emerge among teammates in professional basketball games. Using data from logs of National Basketball Association (NBA) games of the 2008-9 season, we estimated a series of conditional logistic regression models to test the impact of different factors on the probability that a given player would assist another player in scoring a basket. Our analysis found evidence for a direct reciprocity effect in which players who had "received" assists in the past tended to subsequently reciprocate their benefactors. Further, this tendency was time-dependent, with the probability of repayment highest soon after receiving an assist and declining as game time passed. We found no evidence for generalized reciprocity - a tendency to "pay forward" assists - and only very limited evidence for indirect reciprocity - a tendency to reward players who had sent others many assists. These findings highlight the power of reciprocity to shape human behavior, even in a setting characterized by extensive planning, division of labor, quick decision-making, and a focus on inter-group competition.

  20. Reciprocity on the hardwood: passing patterns among professional basketball players.

    Directory of Open Access Journals (Sweden)

    Robb Willer

    Full Text Available Past theory and research view reciprocal resource sharing as a fundamental building block of human societies. Most studies of reciprocity dynamics have focused on trading among individuals in laboratory settings. But if motivations to engage in these patterns of resource sharing are powerful, then we should observe forms of reciprocity even in highly structured group environments in which reciprocity does not clearly serve individual or group interests. To this end, we investigated whether patterns of reciprocity might emerge among teammates in professional basketball games. Using data from logs of National Basketball Association (NBA games of the 2008-9 season, we estimated a series of conditional logistic regression models to test the impact of different factors on the probability that a given player would assist another player in scoring a basket. Our analysis found evidence for a direct reciprocity effect in which players who had "received" assists in the past tended to subsequently reciprocate their benefactors. Further, this tendency was time-dependent, with the probability of repayment highest soon after receiving an assist and declining as game time passed. We found no evidence for generalized reciprocity - a tendency to "pay forward" assists - and only very limited evidence for indirect reciprocity - a tendency to reward players who had sent others many assists. These findings highlight the power of reciprocity to shape human behavior, even in a setting characterized by extensive planning, division of labor, quick decision-making, and a focus on inter-group competition.

  1. Adaptations to speed endurance training in highly trained soccer players

    DEFF Research Database (Denmark)

    Nyberg, Michael Permin; Fiorenza, Matteo; Lund, Anders

    2016-01-01

    PURPOSE: The present study examined whether a period of additional speed endurance training would improve intense intermittent exercise performance in highly trained soccer players during the season and whether the training changed aerobic metabolism and the level of oxidative enzymes in type I a...

  2. Somatotype of Competitive Youth Soccer Players From Brazil

    Directory of Open Access Journals (Sweden)

    Fidelix Yara Lucy

    2014-10-01

    Full Text Available The aim of this study was to identify the morphological configuration of youth athletes from professional soccer clubs and to verify their differences according to the tactical position on the field. Overall, 67 male players aged 15 to 17 years were evaluated. The examined anthropometric measurements included body mass, body height, skinfolds (triceps, subscapular, supraspinal and medial calf, girths (flexed and tensed arm and calf and breadths (humerus and femur. For statistical purposes, analysis of variance and post hoc Bonferroni and Kruskal-Wallis tests were used. We concluded that goalkeepers were heavier and taller than center backs (p = 0.015 and p = 0.001, midfielders (p = 0.005 and p <0.001 and center forward players (p = 0.024 and p <0.001. The average somatotype for defense, forward and goalkeeper positions was a balanced mesomorph. Midfield players showed ectomorphic-mesomorph characteristics. It was concluded that goalkeepers were characterized as being taller and heavier and that somatotype features of athletes were similar between positions, except for midfield players

  3. Cogeneration: a winning game for the players who risk it

    Energy Technology Data Exchange (ETDEWEB)

    1985-11-01

    Cogeneration holds out the tantalizing prospect of lower utility rates and affordable energy. But the stakes are high. Now an expert player - the cogen developer - offers to negotiate the gameboard and guarantee a win to those willing to take a chance on his services.

  4. Adolescents risky MP3-player listening and its psychosocial correlates

    NARCIS (Netherlands)

    Vogel, Ineke; Brug, Johannes; van der Ploeg, Catharina P. B.; Raat, Hein

    2011-01-01

    Analogue to occupational noise-induced hearing loss, MP3-induced hearing loss may be evolving into a significant social and public health problem. To inform prevention strategies and interventions, this study investigated correlates of adolescents' risky MP3-player listening behavior primarily infor

  5. Concussion Education for High School Football Players: A Pilot Study

    Science.gov (United States)

    Manasse-Cohick, Nancy J.; Shapley, Kathy L.

    2014-01-01

    This survey study compared high school football players' knowledge and attitudes about concussion before and after receiving concussion education. There were no significant changes in the Concussion Attitude Index. Results revealed a statistically significant difference in the athletes' scores for the Concussion Knowledge Index, "t"(244)…

  6. Enhancing Performance & Preventing Injuries in Team Sport Players

    NARCIS (Netherlands)

    van der Does, Hendrike

    2016-01-01

    Next to physical load and recovery as a result of training, psychosocial stress and recovery affect performance and injury risk of team sport players. This can be concluded based on a series of studies that focus on the relation between jumping technique, training load, training recovery, psychosoci

  7. Development of Repeated Sprint Ability in Talented Youth Basketball Players

    NARCIS (Netherlands)

    te Wierike, Sanne C. M.; de Jong, Mark C.; Tromp, Eveline J. Y.; Vuijk, Pieter J.; Lemmink, Koen A. P. M.; Malina, Robert M.; Elferink-Gemser, Marije T.; Visscher, Chris

    2014-01-01

    te Wierike, SCM, de Jong, MC, Tromp, EJY, Vuijk, PJ, Lemmink, KAPM, Malina, RM, Elferink-Gemser, MT, and Visscher, C. Development of repeated sprint ability in talented youth basketball players. J Strength Cond Res 28(4): 928-934, 2014-Factors affecting repeated sprint ability (RSA) were evaluated i

  8. LIPOSARCOMA OF THE KNEE IN A TENNIS PLAYER: CASE REPORT

    Science.gov (United States)

    Filho, Jorge Sayum; Sayum, Jorge; de Carvalho, Rogério Teixeira; Garms, Emerson; Ramos, Leonardo Addeo; Matsuda, Marcelo Mitsura; Ejnisman, Benno; Cohen, Moisés

    2015-01-01

    Liposarcoma is an uncommon malignant tumor. It originates in the mesenchymal cells, and is the most common of the soft tissue sarcomas. The authors report a case of a 40 year-old male tennis player with liposarcoma in the posterior right knee and distal thigh region. PMID:27047841

  9. Generic Physiological Features as Predictors of Player Experience

    DEFF Research Database (Denmark)

    Martínez, Héctor Pérez; Garbarino, Maurizio; Yannakakis, Georgios N.

    2011-01-01

    This paper examines the generality of features extracted from heart rate (HR) and skin conductance (SC) signals as predictors of self-reported player affect expressed as pairwise preferences. Artificial neural networks are trained to accurately map physiological features to expressed affect in two...

  10. Monitoring load, recovery and performance in young elite soccer players

    NARCIS (Netherlands)

    Brink, Michel S.; Nederhof, Esther; Visscher, Chris; Schmikli, Sandor L.; Lemmink, Koen A. P. M.

    2010-01-01

    Brink, MS, Nederhof, E, Visscher, C, Schmikli, SL, and Lemmink, KAPM. Monitoring load, recovery, and performance in young elite soccer players. J Strength Cond Res 24(3): 597603, 2010-The purpose of this study was to investigate the relation between training load, recovery, and monthly field test pe

  11. The Development of Attention Skills in Action Video Game Players

    Science.gov (United States)

    Dye, M. W. G.; Green, C. S.; Bavelier, D.

    2009-01-01

    Previous research suggests that action video game play improves attentional resources, allowing gamers to better allocate their attention across both space and time. In order to further characterize the plastic changes resulting from playing these video games, we administered the Attentional Network Test (ANT) to action game players and…

  12. College Students' Usage of Personal Music Players (PMP) during Exercise

    Science.gov (United States)

    Barney, David; Gust, Anita; Liguori, Gary

    2012-01-01

    The purpose of this study was to investigate the use of personal music players (PMPs) during exercise, including their purpose(s), how they affect exercise, and the most common music listened to. A representative sample of 184 undergraduate students from two separate university wellness centers completed a 17-item, content validated questionnaire…

  13. Nosema Tolerant Honeybees (Apis mellifera) Escape Parasitic Manipulation of Apoptosis

    Science.gov (United States)

    Kurze, Christoph; Le Conte, Yves; Dussaubat, Claudia; Erler, Silvio; Kryger, Per; Lewkowski, Oleg; Müller, Thomas; Widder, Miriam; Moritz, Robin F. A.

    2015-01-01

    Apoptosis is not only pivotal for development, but also for pathogen defence in multicellular organisms. Although numerous intracellular pathogens are known to interfere with the host’s apoptotic machinery to overcome this defence, its importance for host-parasite coevolution has been neglected. We conducted three inoculation experiments to investigate in the apoptotic respond during infection with the intracellular gut pathogen Nosema ceranae, which is considered as potential global threat to the honeybee (Apis mellifera) and other bee pollinators, in sensitive and tolerant honeybees. To explore apoptotic processes in the gut epithelium, we visualised apoptotic cells using TUNEL assays and measured the relative expression levels of subset of candidate genes involved in the apoptotic machinery using qPCR. Our results suggest that N. ceranae reduces apoptosis in sensitive honeybees by enhancing inhibitor of apoptosis protein-(iap)-2 gene transcription. Interestingly, this seems not be the case in Nosema tolerant honeybees. We propose that these tolerant honeybees are able to escape the manipulation of apoptosis by N. ceranae, which may have evolved a mechanism to regulate an anti-apoptotic gene as key adaptation for improved host invasion. PMID:26445372

  14. Nosema Tolerant Honeybees (Apis mellifera Escape Parasitic Manipulation of Apoptosis.

    Directory of Open Access Journals (Sweden)

    Christoph Kurze

    Full Text Available Apoptosis is not only pivotal for development, but also for pathogen defence in multicellular organisms. Although numerous intracellular pathogens are known to interfere with the host's apoptotic machinery to overcome this defence, its importance for host-parasite coevolution has been neglected. We conducted three inoculation experiments to investigate in the apoptotic respond during infection with the intracellular gut pathogen Nosema ceranae, which is considered as potential global threat to the honeybee (Apis mellifera and other bee pollinators, in sensitive and tolerant honeybees. To explore apoptotic processes in the gut epithelium, we visualised apoptotic cells using TUNEL assays and measured the relative expression levels of subset of candidate genes involved in the apoptotic machinery using qPCR. Our results suggest that N. ceranae reduces apoptosis in sensitive honeybees by enhancing inhibitor of apoptosis protein-(iap-2 gene transcription. Interestingly, this seems not be the case in Nosema tolerant honeybees. We propose that these tolerant honeybees are able to escape the manipulation of apoptosis by N. ceranae, which may have evolved a mechanism to regulate an anti-apoptotic gene as key adaptation for improved host invasion.

  15. Key attributes of expert NRL referees.

    Science.gov (United States)

    Morris, Gavin; O'Connor, Donna

    2017-05-01

    Experiential knowledge of elite National Rugby League (NRL) referees was investigated to determine the key attributes contributing to expert officiating performance. Fourteen current first-grade NRL referees were asked to identify the key attributes they believed contributed to their expert refereeing performance. The modified Delphi method involved a 3-round process of an initial semi-structured interview followed by 2 questionnaires to reach consensus of opinion. The data revealed 25 attributes that were rated as most important that underpin expert NRL refereeing performance. Results illustrate the significance of the cognitive category, with the top 6 ranked attributes all cognitive skills. Of these, the referees ranked decision-making accuracy as the most important attribute, followed by reading the game, communication, game understanding, game management and knowledge of the rules. Player rapport, positioning and teamwork were the top ranked game skill attributes underpinning performance excellence. Expert referees also highlighted a number of psychological attributes (e.g., concentration, composure and mental toughness) that were significant to performance. There were only 2 physiological attributes (fitness, aerobic endurance) that were identified as significant to elite officiating performance. In summary, expert consensus was attained which successfully provided a hierarchy of the most significant attributes of expert NRL refereeing performance.

  16. Modeling Longitudinal Changes in 5m Sprinting Performance Among Young Male Tennis Players

    NARCIS (Netherlands)

    Kramer, Tamara; Valente-Dos-Santos, Joao; Coelho-E-Silva, Manuel J.; Malina, Robert M.; Huijgen, Barbara C. H.; Smith, Joanne; Elferink-Gemser, Marije T.; Visscher, Chris

    2016-01-01

    Year-to-year changes in sprinting in youth tennis players were examined in a mixed-longitudinal study (256 male players, aged 10-15 years: 993 measurements). Height (h), body mass (BM), lower limb explosive strength (LLES), and a 5-m sprint were measured over five years. During that period, players

  17. Forecasting the Market for New Communication Technology: The Home Video Player Experience.

    Science.gov (United States)

    Klopfenstein, Bruce C.

    This paper describes a critical study of the available forecasts and forecasting studies for the home video player market over a 15-year period which was undertaken to discover why so many forecasts were wrong about consumer adoption of home videocassette players and videodisk players, the reasons for these errors, and ways in which this knowledge…

  18. Algorithms for finding optimal paths in network games with p players

    Directory of Open Access Journals (Sweden)

    R. Boliac

    1997-08-01

    Full Text Available We study the problem of finding optimal paths in network games with p players. Some polynomial-time algorithms for finding optimal paths and optimal by Nash strategies of the players in network games with p players are proposed.

  19. Effect of Core Training on 16 Year-Old Soccer Players

    Science.gov (United States)

    Afyon, Yakup Akif

    2014-01-01

    Core trainings have been widely used by trainers recently in order to improve performance of soccer players. In this context, the aim of this study is to examine the effect of core training on some motoric capabilities of 16 years old soccer players. Thirty certified soccer players who were 16 years old from B.B. Bodrumspor Club in 2013-2014…

  20. Online and live regular poker players: Do they differ in impulsive sensation seeking and gambling practice?

    Science.gov (United States)

    Barrault, Servane; Varescon, Isabelle

    2016-03-01

    Background and aims Online gambling appears to have special features, such as anonymity, speed of play and permanent availability, which may contribute to the facilitation and increase in gambling practice, potentially leading to problem gambling. The aims of this study were to assess sociodemographic characteristics, gambling practice and impulsive sensation seeking among a population of regular poker players with different levels of gambling intensity and to compare online and live players. Methods 245 regular poker players (180 online players and 65 live players) completed online self-report scales assessing sociodemographic data, pathological gambling (SOGS), gambling practice (poker questionnaire) and impulsive sensation seeking (ImpSS). We used SOGS scores to rank players according to the intensity of their gambling practice (non-pathological gamblers, problem gamblers and pathological gamblers). Results All poker players displayed a particular sociodemographic profile: they were more likely to be young men, executives or students, mostly single and working full-time. Online players played significantly more often whereas live players reported significantly longer gambling sessions. Sensation seeking was high across all groups, whereas impulsivity significantly distinguished players according to the intensity of gambling. Discussion Our results show the specific profile of poker players. Both impulsivity and sensation seeking seem to be involved in pathological gambling, but playing different roles. Sensation seeking may determine interest in poker whereas impulsivity may be involved in pathological gambling development and maintenance. Conclusions This study opens up new research perspectives and insights into preventive and treatment actions for pathological poker players.

  1. Pressure at play: measuring player approach and avoidance through the keyboard

    NARCIS (Netherlands)

    Hoogen, Wouter van den; Braad, Eelco; IJsselsteijn, Wijnand

    2014-01-01

    With the increased adoption of real-time objective measurements of player experience, advances have been made in characterising the dynamically changing aspects of the player experience during gameplay itself. A direct coupling to player action, however, is not without challenges. Many physiological

  2. Pressure at play: measuring player approach and avoidance behaviour through the keyboard

    NARCIS (Netherlands)

    Hoogen, Wouter M. van den; Braad, Eelco P.; IJsselsteijn, Wijnand A.

    2014-01-01

    With the increased adoption of real-time objective measurements of player experience, advances have been made in characterising the dynamically changing aspects of the player experience during gameplay itself. A direct coupling to player action, however, is not without challenges. Many physiological

  3. Physical and metabolic demands of training and match-play in the elite football player

    DEFF Research Database (Denmark)

    Bangsbo, Jens; Mohr, Magni; Krustrup, Peter

    2006-01-01

    In soccer, the players perform intermittent work. Despite the players performing low-intensity activities for more than 70% of the game, heart rate and body temperature measurements suggest that the average oxygen uptake for elite soccer players is around 70% of maximum (VO2max). This may be part...

  4. The Ability of Elite Table Tennis Players with Intellectual Disabilities to Adapt Their Service/Return

    Science.gov (United States)

    Van Biesen, Debbie; Verellen, Joeri; Meyer, Christophe; Mactavish, Jennifer; Van de Vliet, Peter; Vanlandewijck, Yves

    2010-01-01

    In this study the ability of elite table tennis players with intellectual disability (ID) to adapt their service/return to specific ball spin characteristics was investigated. This was done by examining the performance of 39 players with ID and a reference group of 8 players without ID on a standardized table tennis specific test battery. The…

  5. Achievement Goals, Motivational Climate and Sportspersonship: A Study of Young Handball Players

    Science.gov (United States)

    Stornes, Tor; Ommundsen, Yngvar

    2004-01-01

    The aim of this study was to investigate the relationships between achievement goals, perceptions of motivational climate and sportspersonship in a sample of young male Norwegian handball players. A cross-sectional study of 440 male handball players aged from 14 to 16 was conducted, in which the players responded to a questionnaire measuring…

  6. Self-Esteem Profile among the Female Futsal-Football Players at Jordanian Clubs

    Science.gov (United States)

    Khasawneh, Aman

    2015-01-01

    This study aimed at identifying the level of physical and body self-esteem among the female futsal - football players at Jordanian clubs. The sample of the study was composed of (38) female players among the Jordanian clubs' players of futsal-football who were chosen randomly out of the study community, and the self-esteem scale was used,…

  7. Comparison of Speed, Agility, Anaerobic Strength and Anthropometric Characteristics in Male Football and Futsal Players

    Science.gov (United States)

    Kartal, Resat

    2016-01-01

    The purpose of this study is to compare speed, agility, anaerobic strength and some anthropometric characteristics in male football and futsal players. The sample of the study is composed of male futsal team players of Aydin Adnan Menderes University (19-24 aged) (n = 12) and Aydin Merkez Yeniköy Football Club players (19-24 aged) (n = 12). Within…

  8. High School Football Players and Their Coaches: A Qualitative Study of Their Relationships

    Science.gov (United States)

    Skaza, Robert J.

    2014-01-01

    This basic qualitative study of high school football coach-player relationships explores the players' perceptions of these relationships, specifically the perceptions the players have of how these relationships influenced their lives. This study allowed the researcher to examine the characteristics of high school football coaches as they relate to…

  9. Changes of standard physiological-perceptual markers and circulating MicroRNAs in response to tennis match-play: A case report of two elite players

    Directory of Open Access Journals (Sweden)

    Hoppe Matthias Wilhelm

    2016-06-01

    Full Text Available This study aimed to describe the acute changes of both standard physiological-perceptual markers and circulating microRNAs in response to tennis match-play in a detailed case report. Two elite male baseliners with comparable tennis experience were tested for anthropometric and fitness related variables and played 2 h of match-play on a red-clay court. The changes of standard physiological-perceptual markers including the heart rate, lactate concertation, creatine kinase activity, urea concentration and rating of perceived exertion as well as circulating microRNA-133a, -486 and -126 expression rates were examined at 10 different time-points (i.e., pre, during and up to 24 h post match-play. Player 2 had lower fitness related variables, but a higher heart rate, lactate concentration, creatine kinase activity and rating of perceived exertion during play than player 1. Player 2 showed an increase in all microRNAs (≤3.83-fold, most evident post match-play, whereas player 1 demonstrated a decrease (≤0.41-fold. The time-course in the changes of all standard physiological-perceptual markers was similar in both players, whereas this of the microRNAs was different. It was concluded that the relative changes of the circulating microRNA-133a, -486 and 126 expression rates of both players differed in response to tennis match-play with respect to the experienced physiological-perceptual stress and the underlying fitness level. Therefore, circulating microRNAs can serve as additional biomarkers for tennis exercise physiology and may be assessed together with standard markers to conclude whether key cellular regulatory processes were induced in response to match-play.

  10. Aerobic Development of Elite Youth Ice Hockey Players.

    Science.gov (United States)

    Leiter, Jeff R; Cordingley, Dean M; MacDonald, Peter B

    2015-11-01

    Ice hockey is a physiologically complex sport requiring aerobic and anaerobic energy metabolism. College and professional teams often test aerobic fitness; however, there is a paucity of information regarding aerobic fitness of elite youth players. Without this knowledge, training of youth athletes to meet the standards of older age groups and higher levels of hockey may be random, inefficient, and or effective. Therefore, the purpose of this study was to determine the aerobic fitness of elite youth hockey players. A retrospective database review was performed for 200 male AAA hockey players between the ages of 13 and 17 (age, 14.4 ± 1.2 years; height, 174.3 ± 8.5 cm; body mass, 67.2 ± 11.5 kg; body fat, 9.8 ± 3.5%) before the 2012-13 season. All subjects performed a graded exercise test on a cycle ergometer, whereas expired air was collected by either a Parvo Medics TrueOne 2400 or a CareFusion Oxycon Mobile metabolic cart to determine maximal oxygen consumption (V[Combining Dot Above]O2max). Body mass, absolute V[Combining Dot Above]O2max, and the power output achieved during the last completed stage increased in successive age groups from age 13 to 15 years (p ≤ 0.05). Ventilatory threshold (VT) expressed as a percentage of V[Combining Dot Above]O2max and the heart rate (HR) at which VT occurred decreased between the ages of 13 and 14 years (p ≤ 0.05), whereas the V[Combining Dot Above]O2 at which VT occurred increased from the age of 14-15 years. There were no changes in relative V[Combining Dot Above]O2max or HRmax between any successive age groups. The aerobic fitness levels of elite youth ice hockey players increased as players age and mature physically and physiologically. However, aerobic fitness increased to a lesser extent at older ages. This information has the potential to influence off-season training and maximize the aerobic fitness of elite amateur hockey players, so that these players can meet standards set by advanced elite age groups.

  11. An Alternative to Keys

    Science.gov (United States)

    O'Hagan, James

    1977-01-01

    For the secondary school, the author discourages the use of dichotomous keys in favor of a punch-card system. The system is readily constructed by students for use in plant and animal classification. (CP)

  12. Key concepts in energy

    CERN Document Server

    Madureira, Nuno Luis

    2014-01-01

    Highlights how key energy concepts surfaced, tracing their evolution throughout history to encompasses four economic concepts and four technological-engineering concepts developed through their history to conclude with current economic and environmental sciences Considers the process of energy-substitutions through complementary usages, hybridization and technological mixes Combines a conceptual approach with key theoretical concepts from engineering, geological and economic sciences providing cross disciplinary overview of energy fundamentals in a short and focused reading

  13. Coupling tendencies during exploratory behaviours of competing players in rugby union dyads.

    Science.gov (United States)

    Correia, Vanda; Passos, Pedro; Araújo, Duarte; Davids, Keith; Diniz, Ana; Kelso, J A Scott

    2016-01-01

    This study investigated interpersonal coordination tendencies in 1vs.1 dyads in rugby union, here expressed by participants' movement velocity towards or away from the sideline as they competed to score or prevent a try. We examined whether coupling tendencies of members of each dyad shaped key performance outcomes (try or successful tackle). Data on movement displacement trajectories of eight male rugby union players (aged 11-12 years) were analysed during performance in 47 trials. To assess coordination tendencies during exploratory behaviours in the dyads, analyses of performance time series data were undertaken using variable time graphs, running correlations and cross-correlations. Results revealed distinct coupling patterns characterised by shifts between synchronous coordination and asynchronous coordination tendencies and uncoordinated actions. Observed behaviours were interpreted as attempts of competing participants to create and perceive possibilities for action while seeking to achieve specific performance goals. Findings also revealed that a variety of patterned relations between participants resulted in different performance outcomes.

  14. Attributes of top elite team-handball players.

    Science.gov (United States)

    Massuça, Luís M; Fragoso, Isabel; Teles, Júlia

    2014-01-01

    Researchers in the field of excellence in sport performance are becoming increasingly focused on the study of sport-specific characteristics and requirements. In accordance with this, the purposes of this study were (a) to examine the morphologic-, fitness-, handball-specific skills and psychological and "biosocial" differences between top elite and nontop elite team-handball players and (b) to investigate the extent to which they may be used to identify top elite team-handball players. One hundred sixty-seven adult male team-handball players were studied and divided in 2 groups: top elite (n = 41) and nontop elite (n = 126). Twenty-eight morphologic-, 9 fitness-, 1 handball-specific skills and 2 psychological-based and 2 "biosocial"-based attributes were used. Top elite and nontop elite groups were compared for each variable of interest using Student's t-test, and 5 logistic regression analyses were performed with the athlete's performance group (top elite or nontop elite) as the dependent variable and the variables of each category as predictors. The results showed that (a) body mass, waist girth, radiale-dactylion length, midstylion-dactylion length, and absolute muscle mass (morphologic model); (b) 30-m sprint time, countermovement jump height and average power, abdominal strength and the class of performance in the Yo-Yo Intermittent Endurance Test (fitness model); (c) offensive power (specific-skills model); (d) ego-based motivational orientation (psychological model); (e) socioeconomic status and the energy spent (for week) in handball activity (biosocial model); significantly (p handball player. Moreover, the fitness model exhibited higher percentages of correct classification (i.e., 91.5%) than all the other models did. This study provided (a) the rational to reduce the battery of tests for evaluation purposes, and (b) the initial step to work on building a multidisciplinary model to predict the probability of a handball athlete to be a top elite player.

  15. Soccer Players Cultural Capital and Its Impact on Migration

    Science.gov (United States)

    Leskošek, Bojan; Vodičar, Janez; Topič, Mojca Doupona

    2016-01-01

    Abstract The purpose of this study was to identify factors that constituted the cultural capital among soccer players. We assumed that in the increasingly globalized world of professional soccer, a player’s success would often depend on migrating and adjusting to life in other countries. Willingness to migrate and successful adjustment are tied to player’s previous attitudes and/or behaviours (habitus), significant support from others, including family members, and previous experiences and success in sports and education. Our hypothesised model of the cultural capital was based on the Pierre Bourdieu’s theoretical framework. It consisted of 26 variables related to three sets of factors: soccer experiences, a family context and support, and educational achievements of the players and their parents. The model was tested using a sample of 79 current soccer coaches who also had been players at the elite level. A factor analysis was used to empirically verify the content of the hypothetical model of the soccer players’ cultural capital. Nine latent factors were extracted and together, they accounted for 55.01% of the total model variance. Individual factors obtained showed a sufficient level of substantial connection. The Cronbach’s alpha value of 0.77 confirmed the internal consistency of the operationalised variables in the hypothetical model. In addition, the impact of these aforementioned life dimensions on the migration of soccer players was studied. The results of the binary logistic regression analysis showed that the first factor of the hypothetical model (F1) had 2.2 times and the second factor (F8) had 3.9 times higher odds for migration abroad. Sociocultural findings using this new assessment approach could help create better “success conditions” in the talent development of young players. PMID:28031770

  16. Comparison of some physical and physiologic properties of soccer players and badminton players of 10-12 years old group

    Directory of Open Access Journals (Sweden)

    Recep Kürkçü

    2009-03-01

    Full Text Available The purpose of this study is aimed to compare some physical characteristics and physiological characteristics of adult footballer and badminton players. The subjects of the study were footballer (18 boys and were badminton players (12 boys who were volunteer at primary school in Şanlıurfa. The volunteers', took part in this study, age, height and the body weight average is determined like this respectively:  Footballers: 11,77 ± 0,54 yıl, 151,40 ± 7,35 cm, 41,83 ± 10,27 kgBadminton players: ise11,58 ± 0,66 yıl, 147,37 ± 8,05 cm, 39,08 ± 9,56 kg    Systolic and diastolic blood pressure, VC, FVC, FEV1 sit-reach 30 meters sprint and left-right hand gripping strength of subjects were measured. The differences between findings which were obtained by measurements from footballers and badminton players were considered with using "t-test" on SPSS Windows 11.     According to the data, differences between age, height, body weight average, diastolic blood pressure VC, FVC, FEV1, sit-reach 30 meters sprint and left hand gripping strength were obtained pointless, in the mean time relaxing heart rate, and sit-reach test (P<0.01, systolic blood pressure and right hand gripping strength values were obtained purposeful on (P<0.05 level.     In conclusion,  physical and physiological characteristics of footballers and badminton players were affected by their sport branch furthermore, relaxing heart rate, systolic blood pressure, sit -reach 30 meters sprint, right hand gripping strength performance of footballers were obtained preferable.

  17. Development of muscular imbalance in the shoulder girdle in volleyball players

    OpenAIRE

    VRBOVÁ, Lucie

    2011-01-01

    This bachelor?s thesis deals with the development of muscular imbalance in the shoulder girdle in volleyball players. The volleyball player?s shoulder is the most exposed and vulnerable joint. In addition, the way the sport has developed, the pressure on this joint has grown. Shoulder pain limits the player?s most important move: the strength and the power of the smash and the smash serve. This thesis consists of two parts: theoretical and a practical. The theoretical part deals with the anat...

  18. Peri-nuclear clustering of mitochondria is triggered during aluminum maltolate induced apoptosis.

    Science.gov (United States)

    Dewitt, David A; Hurd, Jennifer A; Fox, Nena; Townsend, Brigitte E; Griffioen, Kathleen J S; Ghribi, Othman; Savory, John

    2006-07-01

    Synapse loss and neuronal death are key features of Alzheimer's disease pathology. Disrupted axonal transport of mitochondria is a potential mechanism that could contribute to both. As the major producer of ATP in the cell, transport of mitochondria to the synapse is required for synapse maintenance. However, mitochondria also play an important role in the regulation of apoptosis. Investigation of aluminum (Al) maltolate induced apoptosis in human NT2 cells led us to explore the relationship between apoptosis related changes and the disruption of mitochondrial transport. Similar to that observed with tau over expression, NT2 cells exhibit peri-nuclear clustering of mitochondria following treatment with Al maltolate. Neuritic processes largely lacked mitochondria, except in axonal swellings. Similar, but more rapid results were observed following staurosporine administration, indicating that the clustering effect was not specific to Al maltolate. Organelle clustering and transport disruption preceded apoptosis. Incubation with the caspase inhibitor zVAD-FMK effectively blocked apoptosis, however failed to prevent organelle clustering. Thus, transport disruption is associated with the initiation, but not necessarily the completion of apoptosis. These results, together with observed transport defects and apoptosis related changes in Alzheimer disease brain suggest that mitochondrial transport disruption may play a significant role in synapse loss and thus the pathogenesis or Alzheimer's disease.

  19. Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain.

    Directory of Open Access Journals (Sweden)

    Pranav Danthi

    2008-12-01

    Full Text Available Apoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus outer-capsid protein mu1, which functions to penetrate host cell membranes during viral entry, is the primary regulator of apoptosis following reovirus infection. Ectopic expression of full-length and truncated forms of mu1 indicates that the mu1 phi domain is sufficient to elicit a cell death response. To evaluate the contribution of the mu1 phi domain to the induction of apoptosis following reovirus infection, phi mutant viruses were generated by reverse genetics and analyzed for the capacity to penetrate cell membranes and elicit apoptosis. We found that mutations in phi diminish reovirus membrane penetration efficiency by preventing conformational changes that lead to generation of key reovirus entry intermediates. Independent of effects on membrane penetration, amino acid substitutions in phi affect the apoptotic potential of reovirus, suggesting that phi initiates apoptosis subsequent to cytosolic delivery. In comparison to wild-type virus, apoptosis-defective phi mutant viruses display diminished neurovirulence following intracranial inoculation of newborn mice. These results indicate that the phi domain of mu1 plays an important regulatory role in reovirus-induced apoptosis and disease.

  20. Keys through ARQ

    CERN Document Server

    Latif, Mohamed Abdel; Gamal, Hesham El

    2009-01-01

    This paper develops a novel framework for sharing secret keys using the well-known Automatic Repeat reQuest (ARQ) protocol. The proposed key sharing protocol does not assume any prior knowledge about the channel state information (CSI), but, harnesses the available opportunistic secrecy gains using only the one bit feedback, in the form of ACK/NACK. The distribution of key bits among multiple ARQ epochs, in our approach, allows for mitigating the secrecy outage phenomenon observed in earlier works. We characterize the information theoretic limits of the proposed scheme, under different assumptions on the channel spatial and temporal correlation function, and develop low complexity explicit implementations. Our analysis reveals a novel role of "dumb antennas" in overcoming the negative impact of spatial correlation, between the legitimate and eavesdropper channels, on the achievable secrecy rates. We further develop an adaptive rate allocation policy which achieves higher secrecy rates by exploiting the channe...

  1. RB: An essential player in adult neurogenesis.

    Science.gov (United States)

    Fong, Bensun C; Slack, Ruth S

    2017-01-01

    The fundamental mechanisms underlying adult neurogenesis remain to be fully clarified. Members of the cell cycle machinery have demonstrated key roles in regulating adult neural stem cell (NSC) quiescence and the size of the adult-born neuronal population. The retinoblastoma protein, Rb, is known to possess CNS-specific requirements that are independent from its classical role as a tumor suppressor. The recent study by Vandenbosch et al. has clarified distinct requirements for Rb during adult neurogenesis, in the restriction of proliferation, as well as long-term adult-born neuronal survival. However, Rb is no longer believed to be the main cell cycle regulator maintaining the quiescence of adult NSCs. Future studies must consider Rb as part of a larger network of regulatory effectors, including the other members of the Rb family, p107 and p130. This will help elucidate the contribution of Rb and other pocket proteins in the context of adult neurogenesis, and define its crucial role in regulating the size and fate of the neurogenic niche.

  2. Key World Energy Statistics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    The IEA produced its first handy, pocket-sized summary of key energy data in 1997. This new edition responds to the enormously positive reaction to the book since then. Key World Energy Statistics produced by the IEA contains timely, clearly-presented data on supply, transformation and consumption of all major energy sources. The interested businessman, journalist or student will have at his or her fingertips the annual Canadian production of coal, the electricity consumption in Thailand, the price of diesel oil in Spain and thousands of other useful energy facts. It exists in different formats to suit our readers' requirements.

  3. The role of community in the development of elite handball and football players in Denmark.

    Science.gov (United States)

    Rossing, N N; Nielsen, A B; Elbe, A-M; Karbing, D S

    2016-01-01

    The primary purpose of this study was to investigate the effect of the place of early development in a sample of Danish male elite and youth handball and football players. The sample included 366 handball and football players from the elite Danish league in the season 2011-2012 and a comparison sample of youth players under the age of 12 from 2003, including 147,221 football and 26,290 handball players. Odds ratio analysis showed that both population size and density significantly affected the proportional number of youth players per community and the odds of athletes reaching an elite level in football and handball. The odds for youth player registrations in both handball and football increased in rural in contrast to urban communities. However, elite football players primarily came from communities of high density (>1000 pop./km(2)), whereas elite handball players primarily came from less densely populated communities (100 to <250 pop./km(2)). Furthermore, there seems to be a relation between representation of elite and talent clubs in different communities and the probability of becoming an elite player in both sports. The limited number of elite players in both sports from rural communities may be due to national talent development strategies that do not incorporate development support for clubs in rural areas. Additionally, the results of the study clearly suggest the need to include the youth player population to advance research findings in birthplace effect studies.

  4. EXAMINATION OF THE RELATIONSHIP BETWEEN OCCUPATIONAL BURNOUT AND JOB SATISFACTION OF PROFESSIONAL FOOTBALL PLAYERS

    Directory of Open Access Journals (Sweden)

    Hakkı

    2014-04-01

    Full Text Available The aim of the study is to examine the relationship between occupational burnout and job satisfaction levels of professional football players. Data was collected in 2011–2012 football seasons. 79 players from Turkey's Super League, 90 players from first, 135 football players from second and 112 football players from third division; totally 416 football players participated. “Burnout Inventory" with 22 items, developed by Maslach (1981 and adapted to Turkish by Ergin (1992 was used. Minnesota Satisfaction Questionnaire 20 "- Short Form” developed by Weiss et al (1967 and adapted to Turkish by Baycan (1985 was used. SPSS was used for the analysis of the data. Super League football players general job satisfaction levels were significantly higher than 2nd and 3rd division football players. The burnout levels of Super League football players were significantly lower than the others. The occupation burnout and job satisfaction levels of football players have a negative relationship mutually ; while job satisfaction level increased, burnout levels of players reduced. Most remarkable part is that Midfielders have lower external satisfaction than goalkeepers.

  5. How do clarinet players adjust the resonances of their vocal tracts for different playing effects

    CERN Document Server

    Fritz, C; Fritz, Claudia; Wolfe, Joe

    2005-01-01

    In a simple model, the reed of the clarinet is mechanically loaded by the series combination of the acoustical impedances of the instrument itself and of the player's vocal tract. Here we measure the complex impedance spectrum of players' tracts using an impedance head adapted to fit inside a clarinet mouthpiece. A direct current shunt with high acoustical resistance allows players to blow normally, so the players can simulate the tract condition under playing conditions. The reproducibility of the results suggest that the players' "muscle memory" is reliable for this task. Most players use a single, highly stable vocal tract configuration over most of the playing range, except for the altissimo register. However, this 'normal' configuration varies substantially among musicians. All musicians change the configuration, often drastically for "special effects'' such as glissandi and slurs: the tongue is lowered and the impedance magnitude reduced when the player intends to lower the pitch or to slur downwards, a...

  6. Adaptivity to Age, Gender, and Gaming Platform Topology in Physical Multi-Player Games

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Friðriksson, Rafn Vídalín; Björnsson, Davíð Þór

    2012-01-01

    In games where players are competing against each other, it can be of interest to ensure that all players are challenged according to their individual skills. In order to investigate such adaptivity to the individual player in physical multi-player games, we developed a game on modular interactive...... tiles which can be used in both single-player and multi-player mode. We implemented simple adaptivity methods and tested these with different user groups including children and adults of both genders. The results show statistically significant differences in the game interactions between children...... and adults, and between male and female players. Also, results show statistically significant differences in the game interactions between different physical set-ups of the modular interactive tiles, i.e. the interaction depended on the topology of the modular tiles set-up. Changing the physical set...

  7. The Relevance of Apoptosis for Cellular Homeostasis and Tumorogenesis in the Intestine

    Directory of Open Access Journals (Sweden)

    Andrew G Renehan

    2001-01-01

    Full Text Available Intestinal epithelium is a rapidly renewing tissue in which cell homeostasis is regulated by a balance among proliferation, growth arrest, differentiation and apoptosis (programmed cell death. Until recently, studies on oncogenesis have focused on the regulation of cell proliferation. The recognition that apoptosis must be understood to comprehend how appropriate cell numbers are maintained and how alterations in any part of the equation can contribute to malignancy has led to an explosion of research in this field. The first half of this review gives an overview of morphology and mechanisms of apoptosis, emphasizing key areas of genetic control such as the bcl-2 family and p53. The second half of the review focuses on the role of apoptosis in normal cellular homeostasis and tumorigenesis in the gastrointestinal epithelium. The importance of understanding the molecular biology of apoptotic pathways in cancer therapy and future directions are also addressed.

  8. Relations of competitive state anxiety and efficacy of young volleyball players.

    Science.gov (United States)

    Milavić, Boris; Jurko, Damir; Grgantov, Zoran

    2013-05-01

    With the aim of validating the Competitive State Anxiety Inventory on a population of young Croatian volleyball players, 286 examinees, 106 male and 180 female volleyball players (average age of 16.09+/-1.83), filled out the CSAI-2, constructed by Martens, Vealey, Burton, Bump and Smith (1990)1. Given the fact that all scales of the Competitive State Anxiety Inventory have good homogeneity, reliability and sensitivity, it can be concluded that they represent high-quality measuring instruments for measuring psychological characteristics of young volleyball players. Young male and female volleyball players generally have a moderate level of self-confidence, and their cognitive anxiety is more prominent that somatic anxiety. In order to determine the age and gender differences in somatic and cognitive anxiety and self-confidence, parametric analysis of differences was performed and coefficients of the independent samples t-test were calculated. By analysis of differences according to age, it has been established that female junior players, in relation to female youth players, express a significantly lower level of somatic and cognitive anxiety and a significantly higher level of self-confidence. As opposed to female players, male youth and junior players do not differ in any of the analysed variables. By analysis of differences according to gender, it has been established that male youth players have a significantly higher level of self-confidence in comparison to female youth players. No significant differences were found in the level of competitive anxiety and self-confidence by analysis of variance between different player roles. No significant differences were found by discriminant analysis in somatic and cognitive anxiety, and self-confidence of female volleyball players of different situational efficacy. The group of least efficient male volleyball players is characterized by a very low level of self-confidence, while the most efficient group of volleyball

  9. Cryptographic Key Management System

    Energy Technology Data Exchange (ETDEWEB)

    No, author

    2014-02-21

    This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

  10. Locks and Keys Service

    CERN Multimedia

    Claude Ducastel

    The GS-LS-SEM section is pleased to inform you that as from Monday 30 November 2009, the opening hours of the Locks and Keys service will be the following: 08h30 - 12h30 / 13h30 - 16:30, Mondays to Fridays. GS-SEM-LS 73333

  11. Keyed shear joints

    DEFF Research Database (Denmark)

    Hansen, Klaus

    This report gives a summary of the present information on the behaviour of vertical keyed shear joints in large panel structures. An attemp is made to outline the implications which this information might have on the analysis and design of a complete wall. The publications also gives a short...

  12. Key performance indicators

    NARCIS (Netherlands)

    Zwetsloot, G.I.J.M.

    2014-01-01

    This paper addresses how organisations can use OSH performance indicators. This is an important way to mainstream OSH into business management. Key performance indicators (KPIs) should provide objective data on the OSH situation. It is often said that ‘what gets measured gets managed’. Without infor

  13. Position-Dependent Cardiovascular Response and Time-Motion Analysis During Training Drills and Friendly Matches in Elite Male Basketball Players.

    Science.gov (United States)

    Torres-Ronda, Lorena; Ric, Angel; Llabres-Torres, Ivan; de Las Heras, Bernat; Schelling I Del Alcazar, Xavi

    2016-01-01

    The purpose of this study was to measure differences in the cardiovascular workload (heart rate [HR]) and time-motion demands between positional groups, during numerous basketball training drills, and compare the results with in-game competition demands. A convenience sample of 14 top-level professional basketball players from the same club (Spanish First Division, ACB) participated in the study. A total of 146 basketball exercises per player (performed over an 8-week period in 32 team training sessions throughout the competitive season) and 7 friendly matches (FM) played during the preparatory phase were analyzed. The results reveal that HRavg and HRpeak were the highest in FM (158 ± 10; 198 ± 9 b · min(-1), respectively). Time-motion analysis showed 1v1 to be the most demanding drill (53 ± 8 and 46 ± 12 movements per minute for full and half court, respectively). During FM, players performed 33 ± 7 movements per minute. Positional differences exist for both HR and time-motion demands, ranging from moderate to very large for all basketball drills compared with FM. Constraints such as number of players, court size, work-to-rest ratios, and coach intervention are key factors influencing cardiovascular responses and time-motion demands during basketball training sessions. These results demonstrate that systematic monitoring of the physical demands and physiological responses during training and competition can inform and potentially improve coaching strategy, basketball-specific training drills, and ultimately, match performance.

  14. Balance training exercises decrease lower-limb strength asymmetry in young tennis players.

    Science.gov (United States)

    Sannicandro, Italo; Cofano, Giacomo; Rosa, Rosa A; Piccinno, Andrea

    2014-05-01

    -limb strength in young tennis players. Key pointsThe determination of functional asymmetries in the lower-limbs has been the subject of numerous recent investigations aimed at the prevention of injuries in many different contact, limited-contact and non-contact sports.Sport-specific movements in tennis impose different loads upon the two lower-limbs and can cause the development of lower-limb strength asymmetries in young tennis players.The planning of athletic conditioning in young tennis players requires that strength in the lower-limbs is evaluated such that appropriate injury prevention strategies may be inserted into training programmes.Balance training exercises, and indeed all tasks performed on unstable surfaces, lead to benefits in sport-specific performance.

  15. Balance Training Exercises Decrease Lower-Limb Strength Asymmetry in Young Tennis Players

    Science.gov (United States)

    Sannicandro, Italo; Cofano, Giacomo; Rosa, Rosa A.; Piccinno, Andrea

    2014-01-01

    .05). A significant interaction and main effect of training was also observed in the EG: balance training led to a significant reduction in the percent of asymmetry in lower-limb strength, as measured using the SH (p < 0.01), 4m-SSF (p < 0.01) and OLH (p < 0.05) tests. These results confirm that balance training exercises are able to counteract/reduce the degree of asymmetry in lower-limb strength in young tennis players. Key points The determination of functional asymmetries in the lower-limbs has been the subject of numerous recent investigations aimed at the prevention of injuries in many different contact, limited-contact and non-contact sports. Sport-specific movements in tennis impose different loads upon the two lower-limbs and can cause the development of lower-limb strength asymmetries in young tennis players. The planning of athletic conditioning in young tennis players requires that strength in the lower-limbs is evaluated such that appropriate injury prevention strategies may be inserted into training programmes. Balance training exercises, and indeed all tasks performed on unstable surfaces, lead to benefits in sport-specific performance. PMID:24790496

  16. Effect of Court Dimensions on Players' External and Internal Load during Small-Sided Handball Games.

    Science.gov (United States)

    Corvino, Matteo; Tessitore, Antonio; Minganti, Carlo; Sibila, Marko

    2014-05-01

    The aim of this study was to investigate the effect of three different court dimensions on the internal and external load during small-sided handball games. Six male amateur handball players took part in this study and participated in three different 8-min 3vs3 (plus goalkeepers) small-sided handball games (each repeated twice). The three court dimensions were 12×24m, 30×15m and 32×16m. Through Global Positioning System devices (SPI pro elite 15Hz, GPSports) and video analysis, the following parameters were recorded: cyclic and acyclic movements (distance covered and number of technical actions executed), heart rate, and rating of perceived exertion (RPE). Total distance travelled increased with court dimensions (885.2m ± 66.6m in 24×12m; 980.0m ± 73.4m in 30×15m; 1095.0m ± 112.9m in 32×16m, p 5.2 m·s(-1)) highlighted substantial differences: playing with the 30×15m court in comparison to the 24×12m, the players covered less distance in the first speed zone (p = 0.012; ES = 0.70) and more distance in the second (p = 0.049; ES = 0.73) and third (p = 0.012; ES = 0.51) speed zones. Statistical differences were also found between the 24×12m and 32×16m courts: the players covered more distance in the second and third speed zones (p = 0.013, ES = 0.76; p = 0.023 ES = 0.69) with the 32×16m court in comparison to the 24×12m. There was no significant effect of court dimensions on the technical parameters (number of team actions, passes, piston movements toward goal and defensive activities), the number of specific handball jumps and changes of direction, and the time spent in the different heart rate zones. Considering the average data of all the experimental conditions together (24×12m, 30×15m, 32×16m), a pronounced statistical difference was highlighted between the values in first two HR zones and the last two (p handball games can be used to manipulate both external and internal loads on the players. Key pointsTo cover the specific game demands, more

  17. Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis.

    Science.gov (United States)

    Frenzel, Lukas P; Patz, Michaela; Pallasch, Christian P; Brinker, Reinhild; Claasen, Julia; Schulz, Alexandra; Hallek, Michael; Kashkar, Hamid; Wendtner, Clemens-Martin

    2011-01-01

    Given that aggressive DNA damaging chemotherapy shows suboptimal efficacy in chronic lymphocytic leukaemia (CLL), alternative therapeutic approaches are needed. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is able to induce tumour-specific apoptosis. However, apoptosis might be inhibited by elevated levels of X-linked inhibitor of apoptosis (XIAP). Use of XIAP-inhibiting compounds might sensitize primary CLL cells towards TRAIL-mediated apoptosis. A novel small molecule, compound A (CA), an inhibitor of XIAP, was used in combination with TRAIL to induce apoptosis in primary CLL cells (n = 48). XIAP was significantly more highly expressed in primary CLL cells (n = 28) compared to healthy B cells (n = 16) (P = 0·02). Our data obtained by specific knock-down of XIAP by siRNA identified XIAP as the key factor conferring resistance to TRAIL in CLL. Combined treatment with CA/TRAIL significantly increased apoptosis compared to untreated (P = 8·5 × 10⁻¹⁰), solely CA (P = 4·1 × 10⁻¹²) or TRAIL treated (P = 4·8 × 10⁻¹⁰) CLL cells. CA rendered 40 of 48 (83·3%) primary CLL samples susceptible to TRAIL-mediated apoptosis. In particular, cells derived from patients with poor prognosis CLL (ZAP-70(+) , IGHV unmutated, 17p-) were highly responsive to this drug combination. Our highly-effective XIAP inhibitor CA, in concert with TRAIL, shows potential for the treatment of CLL cases with poor prognosis and therefore warrants further clinical investigation.

  18. Apoptosis in irradiated murine tumors.

    Science.gov (United States)

    Stephens, L C; Ang, K K; Schultheiss, T E; Milas, L; Meyn, R E

    1991-09-01

    Early radiation responses of transplantable murine ovarian (OCaI) and hepatocellular (HCaI) carcinomas were examined at 6, 24, 48, 96, and 144 h after single photon doses of 25, 35, or 45 Gy. Previous studies using tumor growth delay and tumor radiocurability assays had shown OCaI tumors to be relatively radiosensitive and HCaI tumors to be radioresistant. At 6 h, approximately 20% of nuclei in OCaI tumors showed aberrations characteristic of cell death by apoptosis. This contrasted to an incidence of 3% in HCaI tumors. Mitotic activity was eliminated in OCaI tumors but was only transiently suppressed in HCaI tumors. At 24-96 h, OCaI tumors continued to display apoptosis and progressive necrosis, whereas HCaI tumors responded by exhibiting marked pleomorphism. Factors other than mitotic activity may influence tumor radiosensitivity, and one of these may be susceptibility to induction of apoptosis (programmed cell death), because this was a prominent early radiation response by the radiosensitive OCaI tumors.

  19. Memory Kernel in the Expertise of Chess Players

    CERN Document Server

    Schaigorodsky, Ana L; Billoni, Orlando V

    2015-01-01

    In this work we investigate a mechanism for the emergence of long-range time correlations observed in a chronologically ordered database of chess games. We analyze a modified Yule-Simon preferential growth process proposed by Cattuto et al., which includes memory effects by means of a probabilistic kernel. According to the Hurst exponent of different constructed time series from the record of games, artificially generated databases from the model exhibit similar long-range correlations. In addition, the inter-event time frequency distribution is well reproduced by the model for realistic parameter values. In particular, we find the inter-event time distribution properties to be correlated with the expertise of the chess players through the memory kernel extension. Our work provides new information about the strategies implemented by players with different levels of expertise, showing an interesting example of how popularities and long-range correlations build together during a collective learning process.

  20. Procedural Personas for Player Decision Modeling and Procedural Content Generation

    DEFF Research Database (Denmark)

    Holmgård, Christoffer

    2016-01-01

    ." These methods for constructing procedural personas are then integrated with existing procedural content generation systems, acting as critics that shape the output of these systems, optimizing generated content for different personas and by extension, different kinds of players and their decision making styles....... This thesis explores methods for creating low-complexity, easily interpretable, generative AI agents for use in game and simulation design. Based on insights from decision theory and behavioral economics, the thesis investigates how player decision making styles may be defined, operationalised, and measured...... in specific games. It further explores how simple utility functions, easily defined and changed by game designers, can be used to construct agents expressing a variety of decision making styles within a game, using a variety of contemporary AI approaches, naming the resulting agents "Procedural Personas...