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Sample records for apoptosis key players

  1. Sphingolipids: Key Regulators of Apoptosis and Pivotal Players in Cancer Drug Resistance

    Directory of Open Access Journals (Sweden)

    Paola Giussani

    2014-03-01

    Full Text Available Drug resistance elicited by cancer cells still constitutes a huge problem that frequently impairs the efficacy of both conventional and novel molecular therapies. Chemotherapy usually acts to induce apoptosis in cancer cells; therefore, the investigation of apoptosis control and of the mechanisms used by cancer cells to evade apoptosis could be translated in an improvement of therapies. Among many tools acquired by cancer cells to this end, the de-regulated synthesis and metabolism of sphingolipids have been well documented. Sphingolipids are known to play many structural and signalling roles in cells, as they are involved in the control of growth, survival, adhesion, and motility. In particular, in order to increase survival, cancer cells: (a counteract the accumulation of ceramide that is endowed with pro-apoptotic potential and is induced by many drugs; (b increase the synthesis of sphingosine-1-phosphate and glucosylceramide that are pro-survivals signals; (c modify the synthesis and the metabolism of complex glycosphingolipids, particularly increasing the levels of modified species of gangliosides such as 9-O acetylated GD3 (αNeu5Ac(2-8αNeu5Ac(2-3βGal(1-4βGlc(1-1Cer or N-glycolyl GM3 (αNeu5Ac (2-3βGal(1-4βGlc(1-1Cer and de-N-acetyl GM3 (NeuNH(2βGal(1-4βGlc(1-1Cer endowed with anti-apoptotic roles and of globoside Gb3 related to a higher expression of the multidrug resistance gene MDR1. In light of this evidence, the employment of chemical or genetic approaches specifically targeting sphingolipid dysregulations appears a promising tool for the improvement of current chemotherapy efficacy.

  2. Key Distribution based on Three Player Quantum Games

    CERN Document Server

    Toyota, Norihito

    2010-01-01

    We study a new QKD that is different from the scheme proposed by \\cite{Ramz2}, though it essentially takes our ground on three-player quantum games and Greenberg-Horne-Zeilinger triplet entangled state (GHZ state) \\cite{Gree} is used. In our scheme proposed in this article, Bob and Charlie (and Alice also) that they are players in a game get some common key or information (applied strategies and their payoffs in the game) by knowing some results of the measurement made by Alice. There is not any arbiter in our scheme, since existence of an arbiter increase the risk of wiretapping. For it is difficult to detect wiretapping, when an arbiter repeatedly sends classical information. Lastly we discuss robustness for eavesdrop. We show that though maximally entangled case and non-entangled case provided essentially equivalent way in QKD, the latter is not available in the case there are some eavesdroppers.

  3. DMPD: TLR3 in antiviral immunity: key player or bystander? [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16027039 TLR3 in antiviral immunity: key player or bystander? Schroder M, Bowie AG.... Trends Immunol. 2005 Sep;26(9):462-8. (.png) (.svg) (.html) (.csml) Show TLR3 in antiviral immunity: key pl...ayer or bystander? PubmedID 16027039 Title TLR3 in antiviral immunity: key player or bystander? Authors Schr

  4. RTE: a key player for the Smart Grids

    International Nuclear Information System (INIS)

    One of the main missions of RTE is to ensure at any moment the balance between the generated power and the consumed power; to achieve that goal, RTE has to work with all the Power System players, that is generating units, consumers, distribution operators and neighbouring TSOs. For that reason, RTE is a key player in the Smart Grids deployment. This generation/load balance will indeed be more difficult to obtain in the future because of both the massive penetration of intermittent generation and the active demand which is less predictable. To integrate these new actors or behaviours the best way, RTE has to develop new means to make a more flexible use of its assets. And even if a transmission network can already be considered as 'smart', the effort has to be intensified, especially in the R and D area. Three key technical fields are then to be considered: - Make the use of the existing assets more flexible, - Optimize the market design for the optimal use of the infrastructure, - Develop new facilities with a minimal environmental impact. The first two topics deal with the existing facilities; indeed, considering the assets lifetime and the difficulty to build new lines, it's very important to take advantage as far as possible of the existing network. The third topic is related to network development; the absolute need for new transmission capacities in the future has to cope with environment issues. New operating processes, including new technologies, will be needed. If some part of this work will be carried out at the national scale, more and more projects will be done at the European level. Due to the electricity market development and to the renewables penetration, the variability of the border flows is growing and needs a stronger cooperation between Transmission System Operators. ENTSO-E, the 42TSOs association that is operational since July 2009, will facilitate this common work. The publishing of its 'Research and Development Plan' is a good point. This

  5. Polyphenols as Key Players for the Antileukaemic Effects of Propolis

    Directory of Open Access Journals (Sweden)

    Murtala B. Abubakar

    2014-01-01

    Full Text Available Propolis (a bee product which has a long history of medicinal use by humans has attracted a great deal of research interest in the recent time; this is due to its widely reported biological activities such as antiviral, antifungal, antibacterial, anti-inflammatory, antioxidant, and anticarcinogenic properties. Crude form of propolis and its phenolic contents have both been reported to exhibit antileukaemic effects in various leukaemia cell lines. The ability of the polyphenols found in propolis to arrest cell cycle and induce apoptosis and differentiation in addition to inhibition of cell growth and proliferation makes them promising antileukaemic agents, and hence, they are believed to be a key to the antileukaemic effects of propolis in different types of leukaemia. This paper reviews the molecular bases of antileukaemic activity of both crude propolis and individual polyphenols on various leukaemia cell lines, and it indicates that propolis has the potential to be used in both treatment and prevention of leukaemia. This however needs further evaluation by in vitro, in vivo, and epidemiological studies as well as clinical trials.

  6. Game and players: mitochondrial apoptosis and the therapeutic potential of ursodeoxycholic acid.

    Science.gov (United States)

    Solá, Susana; Aranha, Márcia M; Steer, Clifford J; Rodrigues, Cecília M P

    2007-07-01

    Apoptosis represents a universal and exquisitely efficient cellular suicide pathway essential for a variety of normal biological processes ranging from embryonic development to ageing. In fact, tissue homeostasis is dependent on the perfect balance between positive and negative signals that determines the decision between life and death. Therefore, any imbalance can result in a wide range of pathologic disorders associated with unwanted apoptosis or cell growth. During the apoptotic process, the molecular players interact closely with each other in ways relevant to accelerate or interrupt the cellular death process. In addition, two major pathways of apoptosis activation have been recognized as the "intrinsic" mitochondrial pathway and the "extrinsic" death receptor pathway. Although these pathways act independently to initiate apoptosis, a delicate balance and cross-talk between the extrinsic and intrinsic pathways is thought to occur in many cell types. Interestingly, we have shown that ursodeoxycholic acid (UDCA), an endogenous hydrophilic bile acid, is a potent inhibitor of apoptosis by either stabilizing the mitochondrial membrane or modulating the expression of specific upstream targets. Herein, we review the main effectors involved in the death machinery, describe how they interact to regulate apoptosis, and discuss the main pathways that control cell death and survival. Further, we address multiple interesting targets as well as the potential application of UDCA as a therapeutic modality for apoptosis-related disorders. PMID:17489439

  7. Clusterin: a key player in cancer chemoresistance and its inhibition

    Directory of Open Access Journals (Sweden)

    Koltai T

    2014-03-01

    Full Text Available Tomas Koltai Gerencia de Efectores Sanitarios Propios, Instituto Nacional de la Seguridad Social para Jubilados y Pensionados, Buenos Aires, República Argentina Abstract: Clusterin is a heterodimeric disulfide-linked glycoprotein (449 amino acids isolated in the rat prostate after castration. It is widely distributed in different tissues and highly conserved in species. There are two isoforms (1 and 2 with antagonistic actions regarding apoptosis. Clusterin is implicated in a number of biological processes, including lipid transport, membrane recycling, cell adhesion, programmed cell death, and complement cascade, representing a truly multifunctional protein. Isoform 2 is overexpressed under cellular stress conditions and protects cells from apoptosis by impeding Bax actions on the mitochondrial membrane and exerts other protumor activities, like phosphatidylinositol 3-kinase/protein kinase B pathway activation, modulation of extracellular signal-regulated kinase 1/2 signaling and matrix metallopeptidase-9 expression, increased angiogenesis, modulation of the nuclear factor kappa B pathway, among others. Its overexpression should be considered as a nonspecific cellular response to a wide variety of tissue insults like cytotoxic chemotherapy, radiation, excess of free oxygen radicals, androgen or estrogen deprivation, etc. A review of the recent literature strongly suggests potential roles for custirsen in particular, and proapoptosis treatments in general, as novel modalities in cancer management. Inhibition of clusterin is known to increase the cytotoxic effects of chemotherapeutic agents, and custirsen, a second-generation antisense oligonucleotide that blocks clusterin, is being tested in a Phase III clinical trial after successful results were achieved in Phase II studies. A major issue in cancer evolution that remains unanswered is whether clusterin represents a driving force of tumorigenesis or a late phenomenon after chemotherapy. This

  8. Alveologenesis: key cellular players and fibroblast growth factor 10 signaling

    OpenAIRE

    Chao, Cho-Ming; Moiseenko, Alena; Zimmer, Klaus-Peter; Bellusci, Saverio

    2016-01-01

    Background Alveologenesis is the last stage in lung development and is essential for building the gas-exchanging units called alveoli. Despite intensive lung research, the intricate crosstalk between mesenchymal and epithelial cell lineages during alveologenesis is poorly understood. This crosstalk contributes to the formation of the secondary septae, which are key structures of healthy alveoli. Conclusions A better understanding of the cellular and molecular processes underlying the formatio...

  9. Key players and activities across the ERP life cycle: A temporal perspective

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available Enterprise Resource Planning (ERP systems are enterprise wide systems that, because of their integration, automate all of a company's business processes. They have rapidly become the de facto industry standard for replacement of legacy systems. In this paper I analyze using an information theory approach the temporal aspects of key players and activities specific to Romanian SME's ERP implementations with focus on both generic and unique aspects

  10. Colorectal cancer prevention: Perspectives of key players from social networks in a low-income rural US region

    Science.gov (United States)

    Schoenberg, Nancy E.; Eddens, Kathryn; Jonas, Adam; Snell-Rood, Claire; Studts, Christina R.; Broder-Oldach, Benjamin; Katz, Mira L.

    2016-01-01

    Social networks influence health behavior and health status. Within social networks, “key players” often influence those around them, particularly in traditionally underserved areas like the Appalachian region in the USA. From a total sample of 787 Appalachian residents, we identified and interviewed 10 key players in complex networks, asking them what comprises a key player, their role in their network and community, and ideas to overcome and increase colorectal cancer (CRC) screening. Key players emphasized their communication skills, resourcefulness, and special occupational and educational status in the community. Barriers to CRC screening included negative perceptions of the colonoscopy screening procedure, discomfort with the medical system, and misinformed perspectives on screening. Ideas to improve screening focused on increasing awareness of women's susceptibility to CRC, providing information on different screening tests, improving access, and the key role of health-care providers and key players themselves. We provide recommendations to leverage these vital community resources. PMID:26905402

  11. LitMiner and WikiGene: identifying problem-related key players of gene regulation using publication abstracts

    OpenAIRE

    Maier, Holger; Döhr, Stefanie; Grote, Korbinian; O'Keeffe, Sean; Werner, Thomas; de Angelis, Martin Hrabé; Schneider, Ralf

    2005-01-01

    The LitMiner software is a literature data-mining tool that facilitates the identification of major gene regulation key players related to a user-defined field of interest in PubMed abstracts. The prediction of gene-regulatory relationships is based on co-occurrence analysis of key terms within the abstracts. LitMiner predicts relationships between key terms from the biomedical domain in four categories (genes, chemical compounds, diseases and tissues). Owing to the limitations (no direction,...

  12. Key Players in I-DmoI Endonuclease Catalysis Revealed from Structure and Dynamics.

    Science.gov (United States)

    Molina, Rafael; Besker, Neva; Marcaida, Maria Jose; Montoya, Guillermo; Prieto, Jesús; D'Abramo, Marco

    2016-05-20

    Homing endonucleases, such as I-DmoI, specifically recognize and cleave long DNA target sequences (∼20 bp) and are potentially powerful tools for genome manipulation. However, inefficient and off-target DNA cleavage seriously limits specific editing in complex genomes. One approach to overcome these limitations is to unambiguously identify the key structural players involved in catalysis. Here, we report the E117A I-DmoI mutant crystal structure at 2.2 Å resolution that, together with the wt and Q42A/K120M constructs, is combined with computational approaches to shed light on protein cleavage activity. The cleavage mechanism was related both to key structural effects, such as the position of water molecules and ions participating in the cleavage reaction, and to dynamical effects related to protein behavior. In particular, we found that the protein perturbation pattern significantly changes between cleaved and noncleaved DNA strands when the ions and water molecules are correctly positioned for the nucleophilic attack that initiates the cleavage reaction, in line with experimental enzymatic activity. The proposed approach paves the way for an effective, general, and reliable procedure to analyze the enzymatic activity of endonucleases from a very limited data set, i.e., structure and dynamics. PMID:26909878

  13. The strategy of the key players in the African oil sector (the Gulf of Guinea)?

    International Nuclear Information System (INIS)

    The African oil industry, (particularly in the deep water offshore fields of the Gulf of Guinea), is symbolic of the new balance of power taking shape in the oil industry between the international companies and the host state on the one hand, and between the petrol companies themselves on the other. In an area rich in potential and which has become highly competitive, the traditional players in the region's oil development sector (Shell, Chevron and TotalFinaElf) which have for so long been sheltered from genuine competition in their respective areas of activity, must now face up to the renewed ambitions of new 'Super Majors' (in particular ExxonMobil), not to mention those of many independent companies seeking to internationalize their business. Several reasons explain this change. Firstly, the main developments are now taking place offshore with deep water drilling, and financial solidity and technological competence have replaced the closeness of political links as key factors of success. In these conditions, the risk of long term marginalization for the medium-sized companies is considerable. Secondly, the need to achieve profitability stressed by the major petrol groups is opening the door to the independents who are operating a niche policy (based on marginal or mature fields which no longer interest the majors). This type of competition tends to promote activity and to open up new countries to exploration and production (in particular Equatorial Guinea). (author)

  14. Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Kiang, Karrie Mei-Yee; Zhang, Xiao-Qin; Leung, Gilberto Ka-Kit, E-mail: gilberto@hku.hk [Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong (China)

    2015-07-29

    Long non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system (CNS), will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed.

  15. History and Development of Coronal Mass Ejections as a Key Player in Solar Terrestrial Relationship

    CERN Document Server

    Gopalswamy, Nat

    2016-01-01

    Coronal mass ejections (CMEs) are relatively a recently-discovered phenomenon, in 1971, some fifteen years into the Space Era. It took another two decades to realize that CMEs are the most important players in solar terrestrial relationship as the root cause of severe weather in Earth's space environment. CMEs are now counted among the major natural hazards because they cause large solar energetic particle (SEP) events and major geomagnetic storms, both of which pose danger to humans and their technology in space and ground. Geomagnetic storms discovered in the 1700s, solar flares discovered in the 1800s, and SEP events discovered in the1900s are all now found to be closely related to CMEs via various physical processes occurring at various locations in and around CMEs, when they interact with the ambient medium. This article identifies a number of key developments that preceded the discovery of white-light CMEs suggesting that CMEs were waiting to be discovered. The last two decades witnessed an explosion of...

  16. Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis

    Directory of Open Access Journals (Sweden)

    Karrie Mei-Yee Kiang

    2015-07-01

    Full Text Available Long non-coding RNAs (LncRNAs represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may therefore be exploited for the purposes of sub-classification, diagnosis and prognosis. LncRNAs may also serve as potential therapeutic targets as well as a novel biomarkers in the treatment of glioma. In this article, the functional aspects of lncRNAs, particularly within the central nervous system (CNS, will be briefly discussed, followed by highlights of the important roles of lncRNAs in mediating critical steps during glioma development. In addition, the key lncRNA players and their possible mechanistic pathways associated with gliomagenesis will be addressed.

  17. Key players of singlet oxygen-induced cell death in plants

    Directory of Open Access Journals (Sweden)

    Christophe Laloi

    2015-02-01

    Full Text Available The production of reactive oxygen species (ROS is an unavoidable consequence of oxygenic photosynthesis. Singlet oxygen (1O2 is a highly reactive species to which has been attributed a major destructive role during the execution of ROS-induced cell death in photosynthetic tissues exposed to excess light. The study of the specific biological activity of 1O2 in plants has been hindered by its high reactivity and short lifetime, the concurrent production of other ROS under photooxidative stress, and limited in vivo detection methods. However, during the last fifteen years, the isolation and characterization of two 1O2-overproducing mutants in Arabidopsis thaliana, flu and ch1, has allowed the identification of genetically controlled 1O2 cell death pathways and a 1O2 acclimation pathway that are triggered at sub-cytotoxic concentrations of 1O2. The study of flu has revealed the control of cell death by the plastid proteins EXECUTER (EX1 and EX2. In ch1, oxidized derivatives of beta-carotene, such as beta-cyclocitral and dihydroactinidiolide, have been identified as important upstream messengers in the 1O2 signaling pathway that leads to stress acclimation. In both the flu and ch1 mutants, phytohormones act as important promoters or inhibitors of cell death. In particular, jasmonate has emerged as a key player in the decision between acclimation and cell death in response to 1O2. Although the flu and ch1 mutants show many similarities, especially regarding their gene expression profiles, key differences, such as EXECUTER-independent cell death in ch1, have also been observed and will need further investigation to be fully understood.

  18. Experiences in methods to involve key players in planning protective actions in the case of a nuclear accident

    International Nuclear Information System (INIS)

    A widely used method in the planning of protective actions is to establish a stakeholder network to generate a comprehensive set of generic protective actions. The aim is to increase competence and build links for communication and coordination. The approach of this work was to systematically evaluate protective action strategies in the case of a nuclear accident. This was done in a way that the concerns and issues of all key players could be transparently and equally included in the decision taken. An approach called Facilitated Decision Analysis Workshop has been developed and tested. The work builds on case studies in which it was assumed that a hypothetical accident had led to a release of considerable amounts of radionuclides and, therefore, various types of countermeasures had to be considered. Six workshops were organised in the Nordic countries where the key players were represented, i.e. authorities, expert organisations, industry and agricultural producers. (authors)

  19. Experiences in methods to involve key players in planning protective actions in a case of nuclear accident

    International Nuclear Information System (INIS)

    Full text: Openness, transparency and key players participation are all important for balanced decision making in public issues. The emergency exercises involve commonly representatives from various sectors of the society to increase competence and build links for communication and coordination. A different approach has been a set of meetings where the key players aimed to plan comprehensive set of generic protective actions. The approach of this work was to develop methods and techniques to evaluate systematically and comprehensively protective action strategies. This was done in a way that all key players' concerns and issues related to decisions on protective actions could be aggregated openly and equally. We have developed and tested an approach called facilitated workshop based an theory of decision analysis. The work builds on case studies in which it was assumed that a hypothetical accident at a nuclear power plant had led to a release of considerable amounts of radionuclides and therefore various types of protective actions should be considered. Altogether six workshops were organized where all key players were represented, i.e., authorities, expert organizations, industry and producers. The participants were those who are responsible for preparing advice or making presentations of matters to those responsible for formal decision-making. Many preparatory meetings were held with various experts. It was seen essential that the setup followed strictly the decision-making process the participants are accustomed with. The realistic nature and the disciplined process of a facilitated workshop, and committed to decision-making yielded insight on what information should be collected or studied. Information should be in the proper form needed in decision-making. For example, the study revealed the need to further develop methods to assess the radiological and cost implications of different countermeasures realistically. In order to provide consequence assessments

  20. B-lymphocytes as key players in chemical-induced asthma.

    Directory of Open Access Journals (Sweden)

    Vanessa De Vooght

    Full Text Available T-lymphocytes and B-lymphocytes are key players in allergic asthma, with B-lymphocytes producing antigen-specific immunoglobulins E (IgE. We used a mouse model of chemical-induced asthma and transferred B-lymphocytes from sensitized animals into naïve wild type mice, B-lymphocyte knock-out (B-KO mice or severe combined immunodeficiency (SCID mice. On days 1 and 8, BALB/c mice were dermally sensitized with 0.3% toluene diisocyanate (TDI (20 µl/ear. On day 15, mice were euthanized and the auricular lymph nodes isolated. B-lymphocytes (CD19(+ were separated from the whole cell suspension and 175,000 cells were injected in the tail vein of naïve wild type, B-KO or SCID mice. Three days later, the mice received a single oropharyngeal challenge with 0.01% TDI (20 µl or vehicle (acetone/olive oil (AOO (controls. Airway reactivity to methacholine and total and differential cell counts in the bronchoalveolar lavage (BAL fluid were measured 24 hours after challenge. B-lymphocytes of AOO or TDI-sensitized mice were characterized for the expression of surface markers and production of cytokines. We found that transfer of B-cells obtained from mice dermally sensitized to toluene diisocyanate (TDI into naïve wild type mice, B-KO mice or SCID mice led, within three days, to an acute asthma-like phenotype after an airway challenge with TDI. This response was specific and independent of IgE. These B-lymphocytes showed antigen presenting capacities (CD80/CD86 and CD40 and consisted of B effector (Be2- (IL-4 and Be1-lymphocytes (IFN-γ. The transferred B-lymphocytes were visualized near large airways, 24 hours after TDI challenge. Thus, B-lymphocytes can provoke an asthmatic response without the action of T-lymphocytes and without major involvement of IgE.

  1. Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders

    NARCIS (Netherlands)

    De Keyser, Jacques; Mostert, Jop P.; Koch, Marcus W.

    2008-01-01

    Once considered little more than the glue that holds neurons in place, astrocytes are now becoming appreciated for the key roles they play in central nervous system functions. They supply neurons and oligodendrocytes with substrates for energy metabolism, control extracellular water and electrolyte

  2. Phenols and lignin: Key players in reducing enzymatic hydrolysis yields of steam-pretreated biomass in presence of laccase.

    Science.gov (United States)

    Oliva-Taravilla, Alfredo; Tomás-Pejó, Elia; Demuez, Marie; González-Fernández, Cristina; Ballesteros, Mercedes

    2016-01-20

    Phenols are known as inhibitors for cellulases and fermentative microorganisms in bioethanol production processes. The addition of laccases removes the phenolic compounds and subsequently reduces the lag phase of the fermentative microorganism. However, the application of laccases diminishes glucose release during the enzymatic hydrolysis. In this study a model cellulosic substrate (Sigmacell) together with lignin extract, whole steam-pretreated wheat straw (slurry) and its water insoluble solid fraction (WIS) were subjected to enzymatic hydrolysis to evaluate the effects of laccase treatment in presence of lignin and phenols. The presence of laccase in enzymatic hydrolysis of Sigmacell with lignin extract reduced glucose yield by 37% compared with assays without laccase. Furthermore, this reduction was even more marked in presence of phenols (55% reduction). Interestingly, when hydrolyzing WIS, the addition of phenols coupled with laccase treatment did not show a reduction when compared with only laccase addition. This fact suggests the key role of lignin in the hydrolysis inhibition since in WIS the ratio cellulase per gram of lignin was much lower than in Sigmacell experiments. Finally, the lower cellobiose and xylose recoveries point out that phenolic oligomers formed by laccase oxidation play important roles in the inhibition of endoglucanases, cellobiohydrolases and xylanases. To conclude, the proportion of lignin and the composition of phenols are key players in the inhibition of cellulases when the enzymatic hydrolysis is combined with laccases detoxification. PMID:26684987

  3. GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance

    DEFF Research Database (Denmark)

    Biensø, Rasmus Sjørup; Jørgensen, Stine Ringholm; Kiilerich, Kristian;

    2012-01-01

    To elucidate the molecular mechanisms behind physical inactivity-induced insulin resistance in skeletal muscle, 12 young, healthy male subjects completed 7 days of bed rest with vastus lateralis muscle biopsies obtained before and after. In six of the subjects, muscle biopsies were taken from both...... than before bed rest. This bed rest-induced insulin resistance occurred together with reduced muscle GLUT4, hexokinase II, protein kinase B/Akt1, and Akt2 protein level, and a tendency for reduced 3-hydroxyacyl-CoA dehydrogenase activity. The ability of insulin to phosphorylate Akt and activate....... The present findings demonstrate that physical inactivity-induced insulin resistance in muscle is associated with lower content/activity of key proteins in glucose transport/phosphorylation and storage....

  4. Genetic and Ultrastructural Analysis Reveals the Key Players and Initial Steps of Bacterial Magnetosome Membrane Biogenesis.

    Science.gov (United States)

    Raschdorf, Oliver; Forstner, Yvonne; Kolinko, Isabel; Uebe, René; Plitzko, Jürgen M; Schüler, Dirk

    2016-06-01

    Magnetosomes of magnetotactic bacteria contain well-ordered nanocrystals for magnetic navigation and have recently emerged as the most sophisticated model system to study the formation of membrane bounded organelles in prokaryotes. Magnetosome biosynthesis is thought to begin with the formation of a dedicated compartment, the magnetosome membrane (MM), in which the biosynthesis of a magnetic mineral is strictly controlled. While the biomineralization of magnetosomes and their subsequent assembly into linear chains recently have become increasingly well studied, the molecular mechanisms and early stages involved in MM formation remained poorly understood. In the Alphaproteobacterium Magnetospirillum gryphiswaldense, approximately 30 genes were found to control magnetosome biosynthesis. By cryo-electron tomography of several key mutant strains we identified the gene complement controlling MM formation in this model organism. Whereas the putative magnetosomal iron transporter MamB was most crucial for the process and caused the most severe MM phenotype upon elimination, MamM, MamQ and MamL were also required for the formation of wild-type-like MMs. A subset of seven genes (mamLQBIEMO) combined within a synthetic operon was sufficient to restore the formation of intracellular membranes in the absence of other genes from the key mamAB operon. Tracking of de novo magnetosome membrane formation by genetic induction revealed that magnetosomes originate from unspecific cytoplasmic membrane locations before alignment into coherent chains. Our results indicate that no single factor alone is essential for MM formation, which instead is orchestrated by the cumulative action of several magnetosome proteins. PMID:27286560

  5. Glycosyltransferases:key players involved in the modification of plant secondary metabolites

    Institute of Scientific and Technical Information of China (English)

    Jun WANG; Bingkai HOU

    2009-01-01

    Glycosyltransferases are members of the multigene superfamily in plants that can transfer single or multiple activated sugars to a range of plant molecules,resulting in the glycosylation of plant compounds.Although the activities of many glycosyltransferases and their products have been recognized for a long time,only in recent years were some glycosyltransferase genes identified and a few functionally characterized in detail.Glycosylation is thought to be one of the most important modification reactions towards plant secondary metabolites,and plays a key role in maintaining cell homeostasis,thus likely participating in the regulation of plant growth,development and in defense responses to stress environments.With advances in plant genome projects and the development of novel technologies in analyzing gene function,significant progress could be made in gaining new insights into the properties and precise biological roles of plant secondary product glycosyltransferases,and the new knowledge will have extensive application prospects in the catalytic synthesis of glycoconjugates and metabolic engineering of crops.In this review,we summarize the current research,highlighting the possible biological roles,of plant secondary metabolite glycosyltransferases and discuss their potential applications as well as aspects to be further studied in the near future.

  6. Rho family GTPases: Key players in neuronal development, neuronal survival, and neurodegeneration

    Directory of Open Access Journals (Sweden)

    Trisha eStankiewicz

    2014-10-01

    Full Text Available The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (~21 kDa guanine nucleotide binding proteins. The most extensively studied members are RhoA, Rac1, and Cdc42. In the last few decades, studies have demonstrated that Rho family GTPases are important regulatory molecules that link surface receptors to the organization of the actin and microtubule cytoskeletons. Indeed, Rho GTPases mediate many diverse critical cellular processes, such as gene transcription, cell-cell adhesion, and cell cycle progression. However, Rho GTPases also play an essential role in regulating neuronal morphology. In particular, Rho GTPases regulate dendritic arborization, spine morphogenesis, growth cone development, and axon guidance. In addition, more recent efforts have underscored an important function for Rho GTPases in regulating neuronal survival and death. Interestingly, Rho GTPases can exert either a pro-survival or pro-death signal in neurons depending upon both the cell type and neurotoxic insult involved. This review summarizes key findings delineating the involvement of Rho GTPases and their effectors in the regulation of neuronal survival and death. Collectively, these results suggest that dysregulation of Rho family GTPases may potentially underscore the etiology of some forms of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS.

  7. Macropinosomes are Key Players in Early Shigella Invasion and Vacuolar Escape in Epithelial Cells.

    Directory of Open Access Journals (Sweden)

    Allon Weiner

    2016-05-01

    Full Text Available Intracellular pathogens include all viruses, many bacteria and parasites capable of invading and surviving within host cells. Key to survival is the subversion of host cell pathways by the pathogen for the purpose of propagation and evading the immune system. The intracellular bacterium Shigella flexneri, the causative agent of bacillary dysentery, invades host cells in a vacuole that is subsequently ruptured to allow growth of the pathogen within the host cytoplasm. S. flexneri invasion has been classically described as a macropinocytosis-like process, however the underlying details and the role of macropinosomes in the intracellular bacterial lifestyle have remained elusive. We applied dynamic imaging and advanced large volume correlative light electron microscopy (CLEM to study the highly transient events of S. flexneri's early invasion into host epithelial cells and elucidate some of its fundamental features. First, we demonstrate a clear distinction between two compartments formed during the first step of invasion: the bacterial containing vacuole and surrounding macropinosomes, often considered identical. Next, we report a functional link between macropinosomes and the process of vacuolar rupture, demonstrating that rupture timing is dependent on the availability of macropinosomes as well as the activity of the small GTPase Rab11 recruited directly to macropinosomes. We go on to reveal that the bacterial containing vacuole and macropinosomes come into direct contact at the onset of vacuolar rupture. Finally, we demonstrate that S. flexneri does not subvert pre-existing host endocytic vesicles during the invasion steps leading to vacuolar rupture, and propose that macropinosomes are the major compartment involved in these events. These results provide the basis for a new model of the early steps of S. flexneri epithelial cell invasion, establishing a different view of the enigmatic process of cytoplasmic access by invasive bacterial

  8. Macropinosomes are Key Players in Early Shigella Invasion and Vacuolar Escape in Epithelial Cells.

    Science.gov (United States)

    Weiner, Allon; Mellouk, Nora; Lopez-Montero, Noelia; Chang, Yuen-Yan; Souque, Célia; Schmitt, Christine; Enninga, Jost

    2016-05-01

    Intracellular pathogens include all viruses, many bacteria and parasites capable of invading and surviving within host cells. Key to survival is the subversion of host cell pathways by the pathogen for the purpose of propagation and evading the immune system. The intracellular bacterium Shigella flexneri, the causative agent of bacillary dysentery, invades host cells in a vacuole that is subsequently ruptured to allow growth of the pathogen within the host cytoplasm. S. flexneri invasion has been classically described as a macropinocytosis-like process, however the underlying details and the role of macropinosomes in the intracellular bacterial lifestyle have remained elusive. We applied dynamic imaging and advanced large volume correlative light electron microscopy (CLEM) to study the highly transient events of S. flexneri's early invasion into host epithelial cells and elucidate some of its fundamental features. First, we demonstrate a clear distinction between two compartments formed during the first step of invasion: the bacterial containing vacuole and surrounding macropinosomes, often considered identical. Next, we report a functional link between macropinosomes and the process of vacuolar rupture, demonstrating that rupture timing is dependent on the availability of macropinosomes as well as the activity of the small GTPase Rab11 recruited directly to macropinosomes. We go on to reveal that the bacterial containing vacuole and macropinosomes come into direct contact at the onset of vacuolar rupture. Finally, we demonstrate that S. flexneri does not subvert pre-existing host endocytic vesicles during the invasion steps leading to vacuolar rupture, and propose that macropinosomes are the major compartment involved in these events. These results provide the basis for a new model of the early steps of S. flexneri epithelial cell invasion, establishing a different view of the enigmatic process of cytoplasmic access by invasive bacterial pathogens. PMID:27182929

  9. Overcoming barriers to energy efficiency in cooking: a Swiss survey among key players in politics, business, and NGOs

    Energy Technology Data Exchange (ETDEWEB)

    Luethi, Sonja (Inst. for Economy and Environment, Univ. of St. Gallen (Switzerland)). e-mail: sonja.luethi@unisg.ch; Stoe, Eivind (National Inst. for Consumer Research (Norway))

    2009-07-01

    Promoting the purchase of energy-efficient appliances with measures such as labelling is one way to promote energy efficiency. Energy consumption is however also strongly, if not mostly related to the use phase: A labelled energy efficient appliance can still be used in a way that is not energy-efficient. Therefore this paper looks at both the purchase phase and the use phase. Cooking is a daily activity for most people, but only very few think about the energy used while cooking. This paper identifies the strength and relevance of the barriers to the purchase of energy efficient appliances as well as the barriers to energy efficient behaviour in the context of cooking. Further, it discusses how activities from key players (political authorities, energy producers, and NGOs) can overcome these barriers. It particularly examines the potential for change in relation to the windows of opportunities. The main idea behind this theory is that in everyday life it is difficult for consumers to change their behaviour and habits, even if they are well-informed and motivated to do so. However, when certain fundamental changes in life are made, people are susceptible to changes in other aspects as well. The empirical basis of the paper is a qualitative survey that was conducted in the context of the EU FP7 project BARENERGY (Barriers to energy changes among end consumers and households). The results presented here have been collected in interviews of stakeholders from politics, business, and NGOs in Switzerland.

  10. Intestinal CD103+ dendritic cells are key players in the innate immune control of Cryptosporidium parvum infection in neonatal mice.

    Directory of Open Access Journals (Sweden)

    Louis Lantier

    Full Text Available Cryptosporidium parvum is a zoonotic protozoan parasite found worldwide, that develops only in the gastrointestinal epithelium and causes profuse diarrhea. Using a mouse model of C. parvum infection, we demonstrated by conditional depletion of CD11c+ cells that these cells are essential for the control of the infection both in neonates and adults. Neonates are highly susceptible to C. parvum but the infection is self-limited, whereas adults are resistant unless immunocompromised. We investigated the contribution of DC to the age-dependent susceptibility to infection. We found that neonates presented a marked deficit in intestinal CD103+ DC during the first weeks of life, before weaning, due to weak production of chemokines by neonatal intestinal epithelial cells (IEC. Increasing the number of intestinal CD103+ DC in neonates by administering FLT3-L significantly reduced susceptibility to the infection. During infections in neonates, the clearance of the parasite was preceded by a rapid recruitment of CD103+ DC mediated by CXCR3-binding chemokines produced by IEC in response to IFNγ. In addition to this key role in CD103+ DC recruitment, IFNγ is known to inhibit intracellular parasite development. We demonstrated that during neonatal infection CD103+ DC produce IL-12 and IFNγ in the lamina propria and the draining lymph nodes. Thus, CD103+DC are key players in the innate immune control of C. parvum infection in the intestinal epithelium. The relative paucity of CD103+ DC in the neonatal intestine contributes to the high susceptibility to intestinal infection.

  11. THE KEY VIRAL PLAYERS

    Science.gov (United States)

    A number of different types of human enteric viruses cause waterborne outbreaks when individuals are exposed to contaminated drinking and recreational waters. Members of the enterovirus group cause numerous diseases, including gastroenteritis, encephalitis, meningitis, myocard...

  12. Underlying Motives, Moral Agendas and Unlikely Partnerships: The Formulation of the U.S. Trafficking in Victims Protection Act Through the Data and Voices of Key Policy Players

    Directory of Open Access Journals (Sweden)

    Nicole Footen Bromfield

    2012-08-01

    Full Text Available In response to the overwhelming amount of attention to human trafficking, the debates surrounding its definition, and its focus on the sex industry, the purpose of this study was to understand the motivations behind the formation of the Trafficking in Victims Protection Act (TVPA. Using the Advocacy Coalition Framework (ACF as a model, data was collected and analyzed in order to examine the coalition identities of key players and their positions. Through the presentation of in-depth interview data with key policy players involved in the making of the TVPA, this article illustrates how and why the TVPA was formulated, the implications of its development, and the necessity for critical analysis of its effects. The use of alternative frameworks of labor and migration for understanding trafficking is proposed. Further consideration is given to legislative changes to eliminate anti-prostitution ideology and to support anti-oppressive approaches to addressing forced or deceptive working conditions.

  13. Underlying Motives, Moral Agendas and Unlikely Partnerships: The Formulation of the U.S. Trafficking in Victims Protection Act Through the Data and Voices of Key Policy Players

    OpenAIRE

    Nicole Footen Bromfield; Moshoula Capous-Desyllas

    2012-01-01

    In response to the overwhelming amount of attention to human trafficking, the debates surrounding its definition, and its focus on the sex industry, the purpose of this study was to understand the motivations behind the formation of the Trafficking in Victims Protection Act (TVPA). Using the Advocacy Coalition Framework (ACF) as a model, data was collected and analyzed in order to examine the coalition identities of key players and their positions. Through the presentation of in-depth intervi...

  14. A strategic game between key players in a competitive oil market; Um jogo estrategico entre atores-chave em um mercado competitivo de petroleo

    Energy Technology Data Exchange (ETDEWEB)

    Medina, Fernando; Ferreira Filho, Virgilio Jose Martins [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia (COPPE)

    2004-07-01

    This article aims to state a strategic game devised in Theory Game, regarding some aspects present in a highly competitive oil market. A set of strategies for two key players of the world oil industry is created. Both of them are in a conflict of economic interest and make decisions based on rational and conservative principles. Pure and mixed strategies, the minimax optimizing method and the concept of Nash Equilibrium among optimum strategies are used to calculate the expected value for decision for each actor in the game. (author)

  15. ADRB3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis.

    OpenAIRE

    Lirussi, Fréderic; Rakotoniaina, Zo; Madani, Siham; Goirand, Françoise; Breuiller-Fouché, Michelle; Leroy, Marie-Josèphe; Sagot, Paul; Morrison, John; Dumas, Monique; Bardou, Marc

    2008-01-01

    The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear. It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest in the pharmacological management of preterm labor. Although there is evidence implicating ADRB receptors in the control of inflammation, there are minimal data relating specifically to ADRB3. To explore the cellular consequences of chorioamnionitis and detect apoptosis, we...

  16. Mcl-1 is a key regulator of apoptosis resistance in Chlamydia trachomatis-infected cells.

    Directory of Open Access Journals (Sweden)

    Krishnaraj Rajalingam

    Full Text Available Chlamydia are obligate intracellular bacteria that cause variety of human diseases. Host cells infected with Chlamydia are protected against many different apoptotic stimuli. The induction of apoptosis resistance is thought to be an important immune escape mechanism allowing Chlamydia to replicate inside the host cell. Infection with C. trachomatis activates the Raf/MEK/ERK pathway and the PI3K/AKT pathway. Here we show that inhibition of these two pathways by chemical inhibitors sensitized C. trachomatis infected cells to granzyme B-mediated cell death. Infection leads to the Raf/MEK/ERK-mediated up-regulation and PI3K-dependent stabilization of the anti-apoptotic Bcl-2 family member Mcl-1. Consistently, interfering with Mcl-1 up-regulation sensitized infected cells for apoptosis induced via the TNF receptor, DNA damage, granzyme B and stress. Our data suggest that Mcl-1 up-regulation is primarily required to maintain apoptosis resistance in C. trachomatis-infected cells.

  17. Analysis of market & business strategies of key players in UK professional services sector For Tata Consultancy Services MBA 2012

    OpenAIRE

    Pinto, Ajay Don; Sridhar, Geetha

    2012-01-01

    This project is part of the Nottingham University Business School Management Project and TCS’s Global Internship Program which provides an opportunity to work on challenging projects on information technology. The key areas include: improving operational efficiency and productivity; promoting business agility; simplification and transformation; managing enterprise risk and compliance; and enabling the understanding of markets and customers. The project from Tata Consultancy Services (TCS)...

  18. In situ protein-SIP highlights Burkholderiaceae as key players degrading toluene by para ring hydroxylation in a constructed wetland model.

    Science.gov (United States)

    Lünsmann, Vanessa; Kappelmeyer, Uwe; Benndorf, René; Martinez-Lavanchy, Paula M; Taubert, Anja; Adrian, Lorenz; Duarte, Marcia; Pieper, Dietmar H; von Bergen, Martin; Müller, Jochen A; Heipieper, Hermann J; Jehmlich, Nico

    2016-04-01

    In constructed wetlands, organic pollutants are mainly degraded via microbial processes. Helophytes, plants that are commonly used in these systems, provide oxygen and root exudates to the rhizosphere, stimulating microbial degradation. While the treatment performance of constructed wetlands can be remarkable, a mechanistic understanding of microbial degradation processes in the rhizosphere is still limited. We investigated microbial toluene removal in a constructed wetland model system combining 16S rRNA gene sequencing, metaproteomics and (13) C-toluene in situ protein-based stable isotope probing (protein-SIP). The rhizospheric bacterial community was dominated by Burkholderiales and Rhizobiales, each contributing about 20% to total taxon abundance. Protein-SIP data revealed that the members of Burkholderiaceae, the proteins of which showed about 73% of (13) C-incorporation, were the main degraders of toluene in the planted system, while the members of Comamonadaceae were involved to a lesser extent in degradation (about 64% (13) C-incorporation). Among the Burkholderiaceae, one of the key players of toluene degradation could be assigned to Ralstonia pickettii. We observed that the main pathway of toluene degradation occurred via two subsequent monooxygenations of the aromatic ring. Our study provides a suitable approach to assess the key processes and microbes that are involved in the degradation of organic pollutants in complex rhizospheric ecosystems. PMID:26616584

  19. G-protein-coupled receptor heteromers as key players in the molecular architecture of the central nervous system.

    Science.gov (United States)

    Brugarolas, Marc; Navarro, Gemma; Martínez-Pinilla, Eva; Angelats, Edgar; Casadó, Vicent; Lanciego, José L; Franco, Rafael

    2014-08-01

    The overall architecture of the nervous system, especially the CNS, is remarkable. The anatomy of the nervous system is constituted not only by macroscopic and microscopy identifiable regions and neuronal cell types, but also by protein complexes whose identification and localization require sophisticated techniques. G-protein-coupled receptors (GPCRs) constitute an example of proteins that are the key factors in the framework needed to sustain brain and nerve structure and function. The versatility underlying nervous system anatomy takes advantage of a recently discovered feature of GPCRs, the possibility to form heteromers that, placed at specific neuronal subsets and at specific locations (pre-, post-, or peri-synaptic), contribute to attain unique neural functions. PMID:24809909

  20. The Brassinosteroid Signaling Pathway—New Key Players and Interconnections with Other Signaling Networks Crucial for Plant Development and Stress Tolerance

    Directory of Open Access Journals (Sweden)

    Damian Gruszka

    2013-04-01

    Full Text Available Brassinosteroids (BRs are a class of steroid hormones regulating a wide range of physiological processes during the plant life cycle from seed development to the modulation of flowering and senescence. The last decades, and recent years in particular, have witnessed a significant advance in the elucidation of the molecular mechanisms of BR signaling from perception by the transmembrane receptor complex to the regulation of transcription factors influencing expression of the target genes. Application of the new approaches shed light on the molecular functions of the key players regulating the BR signaling cascade and allowed identification of new factors. Recent studies clearly indicated that some of the components of BR signaling pathway act as multifunctional proteins involved in other signaling networks regulating diverse physiological processes, such as photomorphogenesis, cell death control, stomatal development, flowering, plant immunity to pathogens and metabolic responses to stress conditions, including salinity. Regulation of some of these processes is mediated through a crosstalk between BR signalosome and the signaling cascades of other hormones, including auxin, abscisic acid, ethylene and salicylic acid. Unravelling the complicated mechanisms of BR signaling and its interconnections with other molecular networks may be of great importance for future practical applications in agriculture.

  1. The brassinosteroid signaling pathway-new key players and interconnections with other signaling networks crucial for plant development and stress tolerance.

    Science.gov (United States)

    Gruszka, Damian

    2013-01-01

    Brassinosteroids (BRs) are a class of steroid hormones regulating a wide range of physiological processes during the plant life cycle from seed development to the modulation of flowering and senescence. The last decades, and recent years in particular, have witnessed a significant advance in the elucidation of the molecular mechanisms of BR signaling from perception by the transmembrane receptor complex to the regulation of transcription factors influencing expression of the target genes. Application of the new approaches shed light on the molecular functions of the key players regulating the BR signaling cascade and allowed identification of new factors. Recent studies clearly indicated that some of the components of BR signaling pathway act as multifunctional proteins involved in other signaling networks regulating diverse physiological processes, such as photomorphogenesis, cell death control, stomatal development, flowering, plant immunity to pathogens and metabolic responses to stress conditions, including salinity. Regulation of some of these processes is mediated through a crosstalk between BR signalosome and the signaling cascades of other hormones, including auxin, abscisic acid, ethylene and salicylic acid. Unravelling the complicated mechanisms of BR signaling and its interconnections with other molecular networks may be of great importance for future practical applications in agriculture. PMID:23615468

  2. The key to success in elite athletes? Explicit and implicit motor learning in youth elite and non-elite soccer players.

    Science.gov (United States)

    Verburgh, L; Scherder, E J A; van Lange, P A M; Oosterlaan, J

    2016-09-01

    In sports, fast and accurate execution of movements is required. It has been shown that implicitly learned movements might be less vulnerable than explicitly learned movements to stressful and fast changing circumstances that exist at the elite sports level. The present study provides insight in explicit and implicit motor learning in youth soccer players with different expertise levels. Twenty-seven youth elite soccer players and 25 non-elite soccer players (aged 10-12) performed a serial reaction time task (SRTT). In the SRTT, one of the sequences must be learned explicitly, the other was implicitly learned. No main effect of group was found for implicit and explicit learning on mean reaction time (MRT) and accuracy. However, for MRT, an interaction was found between learning condition, learning phase and group. Analyses showed no group effects for the explicit learning condition, but youth elite soccer players showed better learning in the implicit learning condition. In particular, during implicit motor learning youth elite soccer showed faster MRTs in the early learning phase and earlier reached asymptote performance in terms of MRT. Present findings may be important for sports because children with superior implicit learning abilities in early learning phases may be able to learn more (durable) motor skills in a shorter time period as compared to other children. PMID:26788666

  3. MicroRNA-219-5p Inhibits Morphine-Induced Apoptosis by Targeting Key Cell Cycle Regulator WEE1.

    Science.gov (United States)

    Lou, Wei; Zhang, Xingwang; Hu, Xiao-Ying; Hu, Ai-Rong

    2016-01-01

    BACKGROUND To identify the effects of microRNA (miR)-219-5p on morphine-induced apoptosis by targeting WEE1. MATERIAL AND METHODS Forty Balb/C mice (Toll-like receptor 9, TLR9 knockout) were randomly allocated to the experimental and control groups (20 in each group). The baseline miR-219-5p expression was detected using quantitative real-time PCR (qRT-PCR). After morphine was injected at 6 h on the 2nd and 6th days, experimental and control groups received miR-219-5p mimics or miRNA-negative control (NC), respectively, compound injection. Tissues and cells were later obtained from subjects in each group separately after mice were killed. TUNEL assay was used to investigate apoptosis in both groups. RAW264.7 cells were treated with miR-219-5p mimics and controls, respectively. After 24 h, 10 μM of morphine was added at 24 h. Cell apoptosis was assessed by flow cytometer. The WEE1 and Phospho-cdc2 (Tyr15) expressions were examined by Western blotting. RESULTS MiR-219-5p expression in the experimental group was significantly lower than that in the control group (P<0.05). Mice injected with miR-219-5p mimic experienced an evident increase in apoptosis rate compared with the control group (P<0.05). The miR-219-5p NC group and the morphine group both presented an elevated apoptosis rate compared with the blank control group (both, P<0.05). The apoptosis rate in the miR-219-5p mimic group was 10.06%, remarkably lower than in the miR-219-5p NC group and blank control group (both P<0.05). WEE1 and Tyr15 protein expressions in the miR-219-5p NC group and morphine group were obviously stronger than those in the blank control group (all P<0.05). In the miR-219-5p mimic group, WEE1 and Tyr15 protein expressions were significantly lower compared with those in the miR-219-5p NC group and morphine group (all P<0.05). CONCLUSIONS Morphine significantly downregulated the expression of miRNA-219-5p, which targets WEE1 to suppress Tyr15 expressions and activate Cdc2, thus inhibiting

  4. NF-κB plays a key role in microcystin-RR-induced HeLa cell proliferation and apoptosis.

    Science.gov (United States)

    Chen, Liang; Zhang, Xin; Chen, Jun; Zhang, Xuezhen; Fan, Huihui; Li, Shangchun; Xie, Ping

    2014-09-01

    Microcystins (MCs) are well-known cyanobacterial toxins produced in eutrophic waters and can act as potential carcinogens and have caused serious risk to human health. However, pleiotropic even paradoxical actions of cells exposure to MCs have been reported, and the mechanisms of MC-induced tumorigenesis and apoptosis are still unknown. In this study, we performed the first comprehensive in vitro investigation on carcinogenesis associated with nuclear factor kappa B (NF-κB) and its downstream genes in HeLa cells (Human cervix adenocarcinoma cell line from epithelial cells) exposure to MC-RR. HeLa cells were treated with 0, 20, 40, 60, and 80 µg/mL MC-RR for 4, 8, 12, and 24 h. HeLa cells presented dualistic responses to different doses of MCs. CCK8 assay showed that MC-RR exposure evidently enhanced cell viability of HeLa cells at lower MCs doses. Cell cycle and apoptosis analysis revealed that lower MCs doses promoted G1/S transition and cell proliferation while higher doses of MCs induced apoptosis, with a dose-dependent manner. Electrophoretic mobility shift assay (EMSA) revealed that MC-RR could increase/decrease NF-κB activity at lower/higher MC-RR doses, respectively. Furthermore, the expression of NF-κB downstream target genes including c-FLIP, cyclinD1, c-myc, and c-IAP2 showed the same variation trend as NF-κB activity both at mRNA and protein levels, which were induced by lower doses of MC-RR and suppressed by higher doses. Our data verified for the first time that NF-κB pathway may mediate MC-induced cell proliferation and apoptosis and provided a better understanding of the molecular mechanism for potential carcinogenicity of MC-RR. PMID:24932741

  5. Recovering drug-induced apoptosis subnetwork from Connectivity Map data.

    Science.gov (United States)

    Yu, Jiyang; Putcha, Preeti; Silva, Jose M

    2015-01-01

    The Connectivity Map (CMAP) project profiled human cancer cell lines exposed to a library of anticancer compounds with the goal of connecting cancer with underlying genes and potential treatments. Since the therapeutic goal of most anticancer drugs is to induce tumor-selective apoptosis, it is critical to understand the specific cell death pathways triggered by drugs. This can help to better understand the mechanism of how cancer cells respond to chemical stimulations and improve the treatment of human tumors. In this study, using CMAP microarray data from breast cancer cell line MCF7, we applied a Gaussian Bayesian network modeling approach and identified apoptosis as a major drug-induced cellular-pathway. We then focused on 13 apoptotic genes that showed significant differential expression across all drug-perturbed samples to reconstruct the apoptosis network. In our predicted subnetwork, 9 out of 15 high-confidence interactions were validated in the literature, and our inferred network captured two major cell death pathways by identifying BCL2L11 and PMAIP1 as key interacting players for the intrinsic apoptosis pathway and TAXBP1 and TNFAIP3 for the extrinsic apoptosis pathway. Our inferred apoptosis network also suggested the role of BCL2L11 and TNFAIP3 as "gateway" genes in the drug-induced intrinsic and extrinsic apoptosis pathways. PMID:25883971

  6. Structural basis for the inhibition of histone deacetylase 8 (HDAC8, a key epigenetic player in the blood fluke Schistosoma mansoni.

    Directory of Open Access Journals (Sweden)

    Martin Marek

    Full Text Available The treatment of schistosomiasis, a disease caused by blood flukes parasites of the Schistosoma genus, depends on the intensive use of a single drug, praziquantel, which increases the likelihood of the development of drug-resistant parasite strains and renders the search for new drugs a strategic priority. Currently, inhibitors of human epigenetic enzymes are actively investigated as novel anti-cancer drugs and have the potential to be used as new anti-parasitic agents. Here, we report that Schistosoma mansoni histone deacetylase 8 (smHDAC8, the most expressed class I HDAC isotype in this organism, is a functional acetyl-L-lysine deacetylase that plays an important role in parasite infectivity. The crystal structure of smHDAC8 shows that this enzyme adopts a canonical α/β HDAC fold, with specific solvent exposed loops corresponding to insertions in the schistosome HDAC8 sequence. Importantly, structures of smHDAC8 in complex with generic HDAC inhibitors revealed specific structural changes in the smHDAC8 active site that cannot be accommodated by human HDACs. Using a structure-based approach, we identified several small-molecule inhibitors that build on these specificities. These molecules exhibit an inhibitory effect on smHDAC8 but show reduced affinity for human HDACs. Crucially, we show that a newly identified smHDAC8 inhibitor has the capacity to induce apoptosis and mortality in schistosomes. Taken together, our biological and structural findings define the framework for the rational design of small-molecule inhibitors specifically interfering with schistosome epigenetic mechanisms, and further support an anti-parasitic epigenome targeting strategy to treat neglected diseases caused by eukaryotic pathogens.

  7. cAMP and EPAC are key players in the regulation of the signal transduction pathway involved in the α-hemolysin autophagic response.

    Directory of Open Access Journals (Sweden)

    María Belén Mestre

    Full Text Available Staphylococcus aureus is a microorganism that causes serious diseases in the human being. This microorganism is able to escape the phagolysosomal pathway, increasing intracellular bacterial survival and killing the eukaryotic host cell to spread the infection. One of the key features of S. aureus infection is the production of a series of virulence factors, including secreted enzymes and toxins. We have shown that the pore-forming toxin α-hemolysin (Hla is the S. aureus-secreted factor responsible for the activation of the autophagic pathway and that this response occurs through a PI3K/Beclin1-independent form. In the present report we demonstrate that cAMP has a key role in the regulation of this autophagic response. Our results indicate that cAMP is able to inhibit the autophagy induced by Hla and that PKA, the classical cAMP effector, does not participate in this regulation. We present evidence that EPAC and Rap2b, through calpain activation, are the proteins involved in the regulation of Hla-induced autophagy. Similar results were obtained in cells infected with different S. aureus strains. Interestingly, in this report we show, for the first time to our knowledge, that both EPAC and Rap2b are recruited to the S. aureus-containing phagosome. We believe that our findings have important implications in understanding innate immune processes involved in intracellular pathogen invasion of the host cell.

  8. The Cer-cqu gene cluster determines three key players in a β-diketone synthase polyketide pathway synthesizing aliphatics in epicuticular waxes

    DEFF Research Database (Denmark)

    Schneider, Lizette Marais; Adamski, Nikolai M.; Christensen, Caspar Elo;

    2016-01-01

    identification of mutants in their synthesis or transport. The present study discloses three such Eceriferum (cer) genes in barley - Cer-c, Cer-q and Cer-u - known to be tightly linked and functioning in a biochemical pathway forming dominating amounts of β-diketone and hydroxy-β-diketones plus some esterified...... five candidates, of which three were missing in apparent cer-cqu triple mutants. Sequencing more than 50 independent mutants for each gene confirmed their identification. Cer-c is a chalcone synthase-like polyketide synthase, designated diketone synthase (DKS), Cer-q is a lipase/carboxyl transferase...... affect overall protein structure or specific active site residues. The rich diversity of identified mutations will facilitate future studies of three key enzymes involved in synthesis of plant apoplast waxes....

  9. Integrated RNA-Seq and sRNA-Seq Analysis Identifies Chilling and Freezing Responsive Key Molecular Players and Pathways in Tea Plant (Camellia sinensis.

    Directory of Open Access Journals (Sweden)

    Chao Zheng

    Full Text Available Tea [Camellia sinensis (L O. Kuntze, Theaceae] is one of the most popular non-alcoholic beverages worldwide. Cold stress is one of the most severe abiotic stresses that limit tea plants' growth, survival and geographical distribution. However, the genetic regulatory network and signaling pathways involved in cold stress responses in tea plants remain unearthed. Using RNA-Seq, DGE and sRNA-Seq technologies, we performed an integrative analysis of miRNA and mRNA expression profiling and their regulatory network of tea plants under chilling (4℃ and freezing (-5℃ stress. Differentially expressed (DE miRNA and mRNA profiles were obtained based on fold change analysis, miRNAs and target mRNAs were found to show both coherent and incoherent relationships in the regulatory network. Furthermore, we compared several key pathways (e.g., 'Photosynthesis', GO terms (e.g., 'response to karrikin' and transcriptional factors (TFs, e.g., DREB1b/CBF1 which were identified as involved in the early chilling and/or freezing response of tea plants. Intriguingly, we found that karrikins, a new group of plant growth regulators, and β-primeverosidase (BPR, a key enzyme functionally relevant with the formation of tea aroma might play an important role in both early chilling and freezing response of tea plants. Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR analysis further confirmed the results from RNA-Seq and sRNA-Seq analysis. This is the first study to simultaneously profile the expression patterns of both miRNAs and mRNAs on a genome-wide scale to elucidate the molecular mechanisms of early responses of tea plants to cold stress. In addition to gaining a deeper insight into the cold resistant characteristics of tea plants, we provide a good case study to analyse mRNA/miRNA expression and profiling of non-model plant species using next-generation sequencing technology.

  10. Integrated RNA-Seq and sRNA-Seq Analysis Identifies Chilling and Freezing Responsive Key Molecular Players and Pathways in Tea Plant (Camellia sinensis).

    Science.gov (United States)

    Zheng, Chao; Zhao, Lei; Wang, Yu; Shen, Jiazhi; Zhang, Yinfei; Jia, Sisi; Li, Yusheng; Ding, Zhaotang

    2015-01-01

    Tea [Camellia sinensis (L) O. Kuntze, Theaceae] is one of the most popular non-alcoholic beverages worldwide. Cold stress is one of the most severe abiotic stresses that limit tea plants' growth, survival and geographical distribution. However, the genetic regulatory network and signaling pathways involved in cold stress responses in tea plants remain unearthed. Using RNA-Seq, DGE and sRNA-Seq technologies, we performed an integrative analysis of miRNA and mRNA expression profiling and their regulatory network of tea plants under chilling (4℃) and freezing (-5℃) stress. Differentially expressed (DE) miRNA and mRNA profiles were obtained based on fold change analysis, miRNAs and target mRNAs were found to show both coherent and incoherent relationships in the regulatory network. Furthermore, we compared several key pathways (e.g., 'Photosynthesis'), GO terms (e.g., 'response to karrikin') and transcriptional factors (TFs, e.g., DREB1b/CBF1) which were identified as involved in the early chilling and/or freezing response of tea plants. Intriguingly, we found that karrikins, a new group of plant growth regulators, and β-primeverosidase (BPR), a key enzyme functionally relevant with the formation of tea aroma might play an important role in both early chilling and freezing response of tea plants. Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) analysis further confirmed the results from RNA-Seq and sRNA-Seq analysis. This is the first study to simultaneously profile the expression patterns of both miRNAs and mRNAs on a genome-wide scale to elucidate the molecular mechanisms of early responses of tea plants to cold stress. In addition to gaining a deeper insight into the cold resistant characteristics of tea plants, we provide a good case study to analyse mRNA/miRNA expression and profiling of non-model plant species using next-generation sequencing technology. PMID:25901577

  11. Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Aβ1-42 oligomers.

    Science.gov (United States)

    Calamai, Martino; Evangelisti, Elisa; Cascella, Roberta; Parenti, Niccoló; Cecchi, Cristina; Stefani, Massimo; Pavone, Francesco

    2016-02-01

    It is well established that cytotoxic Aβ oligomers are the key factor that triggers the initial tissue and cell modifications eventually culminating in the development of Alzheimer's disease. Aβ1-42 oligomers display a high degree of polymorphism, and several structurally different oligomers have been described. Amongst them, two types, recently classified as A+ and A-, have been shown to possess similar size but distinct toxic properties, as a consequence of their biophysical and structural differences. Here, we have investigated by means of single molecule tracking the oligomer mobility on the plasma membrane of living neuroblastoma cells and the interaction with the ganglioside GM1, a component of membrane rafts. We have found that A+ and A- oligomers display a similar lateral diffusion on the plasma membrane of living cells. However, only the toxic A+ oligomers appear to interact and alter the mobility of GM1. We have also studied the lateral diffusion of each kind of oligomers in cells depleted or enriched in GM1. We found that the content of GM1 influences the diffusion of both types of oligomer, although the effect of the increased levels of GM1 is higher for the A+ type. Interestingly, the content of GM1 also affects significantly the mobility of GM1 molecules themselves. PMID:26656159

  12. Active Player Modelling

    OpenAIRE

    Togelius, Julian; Shaker, Noor; Yannakakis, Georgios N.

    2013-01-01

    We argue for the use of active learning methods for player modelling. In active learning, the learning algorithm chooses where to sample the search space so as to optimise learning progress. We hypothesise that player modelling based on active learning could result in vastly more efficient learning, but will require big changes in how data is collected. Some example active player modelling scenarios are described. A particular form of active learning is also equivalent to an influential forma...

  13. The Roles and Responsibilities of Key Players within Continuing Training (Including Management Training). Report of Subgroup D presented at the Advisory Forum Meeting (Turin, Italy, June 10-12, 1996).

    Science.gov (United States)

    European Training Foundation, Turin (Italy).

    The concept of continuing vocational education and training is being broadened to reflect the needs of individuals, society, and the economy for more flexible, adaptable, learner-centered opportunities. Roles of the various players are in transition. The role and responsibilities of the government should be as follows: strategic leadership; a…

  14. EVALUATING AUSTRALIAN FOOTBALL LEAGUE PLAYER CONTRIBUTIONS USING INTERACTIVE NETWORK SIMULATION

    Directory of Open Access Journals (Sweden)

    Jonathan Sargent

    2013-03-01

    Full Text Available This paper focuses on the contribution of Australian Football League (AFL players to their team's on-field network by simulating player interactions within a chosen team list and estimating the net effect on final score margin. A Visual Basic computer program was written, firstly, to isolate the effective interactions between players from a particular team in all 2011 season matches and, secondly, to generate a symmetric interaction matrix for each match. Negative binomial distributions were fitted to each player pairing in the Geelong Football Club for the 2011 season, enabling an interactive match simulation model given the 22 chosen players. Dynamic player ratings were calculated from the simulated network using eigenvector centrality, a method that recognises and rewards interactions with more prominent players in the team network. The centrality ratings were recorded after every network simulation and then applied in final score margin predictions so that each player's match contribution-and, hence, an optimal team-could be estimated. The paper ultimately demonstrates that the presence of highly rated players, such as Geelong's Jimmy Bartel, provides the most utility within a simulated team network. It is anticipated that these findings will facilitate optimal AFL team selection and player substitutions, which are key areas of interest to coaches. Network simulations are also attractive for use within betting markets, specifically to provide information on the likelihood of a chosen AFL team list "covering the line".

  15. Key Role of the Adenylate Moiety and Integrity of the Adenylate-Binding Site for the NAD(+)/H Binding to Mitochondrial Apoptosis-Inducing Factor.

    Science.gov (United States)

    Sorrentino, Luca; Calogero, Alessandra Maria; Pandini, Vittorio; Vanoni, Maria Antonietta; Sevrioukova, Irina F; Aliverti, Alessandro

    2015-12-01

    Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein with pro-life and pro-death activities, which plays critical roles in mitochondrial energy metabolism and caspase-independent apoptosis. Defects in AIF structure or expression can cause mitochondrial abnormalities leading to mitochondrial defects and neurodegeneration. The mechanism of AIF-induced apoptosis was extensively investigated, whereas the mitochondrial function of AIF is poorly understood. A unique feature of AIF is the ability to form a tight, air-stable charge-transfer (CT) complex upon reaction with NADH and to undergo a conformational switch leading to dimerization, proposed to be important for its vital and lethal functions. Although some aspects of interaction of AIF with NAD(+)/H have been analyzed, its precise mechanism is not fully understood. We investigated how the oxidized and photoreduced wild-type and G307A and -E variants of murine AIF associate with NAD(+)/H and nicotinamide mononucleotide (NMN(+)/H) to determine the role of the adenylate moiety in the binding process. Our results indicate that (i) the adenylate moiety of NAD(+)/H is crucial for the association with AIF and for the subsequent structural reorganization of the complex, but not for protein dimerization, (ii) FAD reduction rather than binding of NAD(+)/H to AIF initiates conformational rearrangement, and (iii) alteration of the adenylate-binding site by the G307E (equivalent to a pathological G308E mutation in human AIF) or G307A replacements decrease the affinity and association rate of NAD(+)/H, which, in turn, perturbs CT complex formation and protein dimerization but has no influence on the conformational switch in the regulatory peptide. PMID:26535916

  16. Cardiovascular molecular imaging of apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Wolters, S.L.; Reutelingsperger, C.P.M. [Maastricht University, Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht (Netherlands); Corsten, M.F.; Hofstra, L. [Maastricht University, Department of Cardiology, Cardiovascular Research Institute Maastricht, P.O. Box 616, Maastricht (Netherlands); Narula, J. [University of California Irvine, Department of Cardiology, Irvine (United States)

    2007-06-15

    Molecular imaging strives to visualise processes at the molecular and cellular level in vivo. Understanding these processes supports diagnosis and evaluation of therapeutic efficacy on an individual basis and thereby makes personalised medicine possible. Apoptosis is a well-organised mode of cell suicide that plays a role in cardiovascular diseases (CVD). Apoptosis is associated with loss of cardiomyocytes following myocardial infarction, atherosclerotic plaque instability, congestive heart failure and allograft rejection of the transplanted heart. Thus, apoptosis constitutes an attractive target for molecular imaging of CVD. Our current knowledge about the molecular players and mechanisms underlying apoptosis offers a rich palette of potential molecular targets for molecular imaging. However, only a few have been successfully developed so far. This review highlights aspects of the molecular machinery and biochemistry of apoptosis relevant to the development of molecular imaging probes. It surveys the role of apoptosis in four major areas of CVD and portrays the importance and future perspectives of apoptosis imaging. The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies. (orig.)

  17. BIMEL is a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximine

    International Nuclear Information System (INIS)

    Arsenic trioxide (ATO) is reported to be an effective therapeutic agent in acute promyelocytic leukemia (APL) through inducing apoptotic cell death. Buthionine sulfoximine (BSO), an oxidative stress pathway modulator, is suggested as a potential combination therapy for ATO-insensitive leukemia. However, the precise mechanism of BSO-mediated augmentation of ATO-induced apoptosis is not fully understood. In this study we compared the difference in cell death of HL60 leukemia cells treated with ATO/BSO and ATO alone, and investigated the detailed molecular mechanism of BSO-mediated augmentation of ATO-induced cell death. HL60 APL cells were used for the study. The activation and expression of a series of signal molecules were analyzed with immunoprecipitation and immunoblotting. Apoptotic cell death was detected with caspases and poly (ADP-ribose) polymerase activation. Generation of intracellular reactive oxygen species (ROS) was determined using a redox-sensitive dye. Mitochondrial outer membrane permeabilization was observed with a confocal microscopy using NIR dye and cytochrome c release was determined with immunoblotting. Small interfering (si) RNA was used for inhibition of gene expression. HL60 cells became more susceptible to ATO in the presence of BSO. ATO/BSO-induced mitochondrial injury was accompanied by reduced mitochondrial outer membrane permeabilization, cytochrome c release and caspase activation. ATO/BSO-induced mitochondrial injury was inhibited by antioxidants. Addition of BSO induced phosphorylation of the pro-apoptotic BCL2 protein, BIMEL, and anti-apoptotic BCL2 protein, MCL1, in treated cells. Phosphorylated BIMEL was dissociated from MCL1 and interacted with BAX, followed by conformational change of BAX. Furthermore, the knockdown of BIMEL with small interfering RNA inhibited the augmentation of ATO-induced apoptosis by BSO. The enhancing effect of BSO on ATO-induced cell death was characterized at the molecular level for clinical use

  18. Cricket club looking for new players

    CERN Multimedia

    Cricket Club

    2016-01-01

    The CERN Cricket Club, having lost several key players, has had a very difficult season so far and is desperately in need of new players. Having qualified for the Cricket Switzerland semi-finals for the last two years (unfortunately losing both), this year we are bottom of the Western Pool, having played the last two league matches with only 10 players. If you are interested in playing cricket please join us at net practice, which takes place on the Prevessin site each Thursday evening from 18:00 to around 20:00 (weather permitting) or send me an e-mail (see below). Please have a look at the Cricket Club web site for more information: http://cern.ch/Club-Cricket/ Chris Onions, President of the CERN Cricket Club   (christopher.onions@gmail.com)

  19. Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells.

    Directory of Open Access Journals (Sweden)

    Loubna Abdel Hadi

    Full Text Available The plant flavonoid luteolin exhibits different biological effects, including anticancer properties. Little is known on the molecular mechanisms underlying its actions in colorectal cancer (CRC. Here we investigated the effects of luteolin on colon cancer cells, focusing on the balance between ceramide and sphingosine-1-phosphate (S1P, two sphingoid mediators with opposite roles on cell fate. Using cultured cells, we found that physiological concentrations of luteolin induce the elevation of ceramide, followed by apoptotic death of colon cancer cells, but not of differentiated enterocytes. Pulse studies revealed that luteolin inhibits ceramide anabolism to complex sphingolipids. Further experiments led us to demonstrate that luteolin induces an alteration of the endoplasmic reticulum (ER-Golgi flow of ceramide, pivotal to its metabolic processing to complex sphingolipids. We report that luteolin exerts its action by inhibiting both Akt activation, and sphingosine kinase (SphK 2, with the consequent reduction of S1P, an Akt stimulator. S1P administration protected colon cancer cells from luteolin-induced apoptosis, most likely by an intracellular, receptor-independent mechanism. Overall this study reveals for the first time that the dietary flavonoid luteolin exerts toxic effects on colon cancer cells by inhibiting both S1P biosynthesis and ceramide traffic, suggesting its dietary introduction/supplementation as a potential strategy to improve existing treatments in CRC.

  20. The Player Engagement Process

    DEFF Research Database (Denmark)

    Schoenau-Fog, Henrik

    2011-01-01

    Engagement is an essential element of the player experience, and the concept is described in various ways in the literature. To gain a more detailed comprehension of this multifaceted concept, and in order to better understand what aspects can be used to evaluate engaging game play and to design...

  1. How to keep A players productive.

    Science.gov (United States)

    Berglas, Steven

    2006-09-01

    After graduating from Harvard Business School with highest honors, Jane rapidly moved up the corporate ladder at a large advertising firm, racking up promotions and responsibilities along the way. By the time she became the company's creative director, she was, in everyone's estimation, an A player--one of the organization's most gifted and productive employees. But although she received an extraordinarily generous pay package and had what some people considered to be one of the most stimulating jobs in the company, Jane felt underappreciated and was talking to head-hunters. Eventually, she was lured away to a competing company that, by her own admission, offered less-challenging work. Both Jane and the advertising firm she left behind lost out. Of course, not all A players are as vulnerable as Jane. Some superstars soar to stunning heights, needing little or no special attention, and have the natural self-confidence and brilliance to stay at the top of their game with elegance and grace. But as every manager knows, megastars with manageable egos are rare. Far more common are people like Jane who are striving to satisfy an inner need for recognition that is often a sign of irrationally low self-esteem. According to the author--an executive coach, management consultant, and former faculty member of the department of psychiatry at Harvard Medical School--if you do not carefully manage the often unconscious need A players have for kudos and appreciation, they will burn out in a way that is damaging to them and unproductive for you. The key is understanding what makes your A players tick. The author suggests that you assist your stars by offering them authentic praise, helping them set boundaries, and teaching them to play nicely with subordinates. In the process, you can turn these high performers into even more effective players. PMID:16967624

  2. The Relative Age Effect and Physical Fitness Characteristics in German Male Tennis Players

    Science.gov (United States)

    Ulbricht, Alexander; Fernandez-Fernandez, Jaime; Mendez-Villanueva, Alberto; Ferrauti, Alexander

    2015-01-01

    The aims of the study were to test: 1) whether the relative age effect (RAE) was prevalent in young (U12-U18) German male tennis players; 2) the potential influence of age and/or skill level on RAE and 3) whether maturity, anthropometric and fitness measures vary according to birth date distribution in elite youth tennis players. For the present study the following male populations were analysed: Overall German population (n = 3.216.811), all players affiliated to the German Tennis Federation (DTB) (n = 120.851), players with DTB official ranking (n = 7165), regional (n = 381) and national (n = 57) squads (11-17 years old), as well as the top 50 German senior players were analyzed. RAEs were more prevalent at higher competitive levels with more players born in the first quarter of the year compared with the reference population for ranked (29.6%), regional (38.1%) and national (42.1%) players. No systematic differences were found in any of the maturity, anthropometric and fitness characteristics of the regional squad players born across different quarters. RAEs are present in the DTB competitive system and it was more pronounced at higher competitive levels. Compared with early born, late born players who were selected into elite squads did not differ in maturation, anthropometric and fitness characteristics. Key points RAEsexist in the selection of youth tennis players in Germany, a greater percentage of players analyzed was born in the 1st quarter compared to all licensed tennis players in the country, and more pronounced with an increased competition level in youth players. Players born later in the selection year and still selected in elite squads were likely to be similar across a range of physical fitness attributes compared with those born earlier in the year. The selection process should be reevaluated and changed to reduce the impact of RAEs on tennis players. PMID:26336351

  3. Mafia: A theoretical study of players and coalitions in a partial information environment

    OpenAIRE

    Braverman, Mark; Etesami, Omid; Mossel, Elchanan

    2008-01-01

    In this paper, we study a game called ``Mafia,'' in which different players have different types of information, communication and functionality. The players communicate and function in a way that resembles some real-life situations. We consider two types of operations. First, there are operations that follow an open democratic discussion. Second, some subgroups of players who may have different interests make decisions based on their own group interest. A key ingredient here is that the iden...

  4. Varying Numbers of Players in Small-Sided Soccer Games Modifies Action Opportunities During Training

    OpenAIRE

    Vilar, Luis; Esteves, Pedro T.; Travassos, Bruno; Passos, Pedro; Lago-Peñas, Carlos; Davids, Keith

    2014-01-01

    This study examined the effects of the numbers of players involved in small-sided team games (underloading and overloading) on opportunities for maintaining ball possession, shooting at goal and passing to teammates during training. These practice constraint manipulations were assumed to alter values of key performance variables identified in previous research, such as interpersonal distances between players and time to intercept shots and passes. Fifteen male soccer players (age: 19.60±1.99 ...

  5. Key; key ring

    International Nuclear Information System (INIS)

    Key and/or key ring is provided with illuminating means which do not require a source of electrical power. The key shown comprises a shank and a head, the head being moulded from a luminous plastic material which glows in the dark. To improve keying together of shank and head there is a pair of holes in the head of the shank. Alternatively the key may be coated in illuminating material or provided with sheath or cover of illuminating material. The key may be provided with company logo. The key ring has attached thereto a hollow plastics container whose interior is coated with a phosphor and which is filled with tritium gas. (author)

  6. Ankle injuries in basketball players.

    Science.gov (United States)

    Leanderson, J; Nemeth, G; Eriksson, E

    1993-01-01

    We carried out a retrospective study of the frequency of ankle sprains in basketball players. A questionnaire about previous ankle injuries, time off after such injuries, current ankle problems, personal data, number of practice hours and the use of prophylactic measures was sent out to 102 basketball players in a second division league in Sweden. Ninety-six players answered. 92% of them had suffered an ankle sprain while playing basketball, and of these 83% reported repeated sprains of one ankle. In the last two seasons, 78% of the players had injured at least one ankle. The injury frequency in the investigation was 5.5 ankle injuries per 1000 activity hours. 22% of the players used some kind of prophylactic support of their ankle joints. Because of the great number of ankle sprains and the disability in terms of time away from sports that they cause, prevention of these injuries is essential. PMID:8536029

  7. Frontal Lobe Function in Chess Players

    OpenAIRE

    Vahid Nejati; Majid Nejati

    2012-01-01

    Chess is considered as a cognitive game because of severe engagement of the mental resources during playing. The purpose of this study is evaluation of frontal lobe function of chess players with matched non-players. Wisconsin Card Sorting Test (WCST) data showed no difference between the player and non-player groups in preservation error and completed categories but surprisingly showed significantly lower grade of the player group in correct response. Our data reveal that chess players dont ...

  8. Sagittal Spinal Morphology in Highly Trained Adolescent Tennis Players

    Science.gov (United States)

    Muyor, José M.; Sánchez-Sánchez, Estefanía; Sanz-Rivas, David; López-Miñarro, Pedro A.

    2013-01-01

    Sports with a predominance of forward-bending and extension postures have been associated with alterations in the sagittal spinal curvatures and greater risk of spinal injury. Because, the tennis players adopt these postures, the aims of this study were: 1) to describe spinal curvatures and pelvic tilt in male and female highly trained adolescent tennis players during relaxed standing posture and with thoracic spine corrected (in prone lying on the floor); and 2) to determine the frequency of thoracic hyperkyphosis and lumbar hypo/hyper lordosis in these postures. Forty adolescent tennis players (24 male and 16 female) aged 13-18 years, participated voluntarily in this study. The Spinal Mouse system was used to measure sagittal spinal curvatures and pelvic tilt. The mean values in the relaxed standing posture were 43.83° ± 7.87° (thoracic kyphosis), - 27.58° ± 7.01° (lumbar lordosis), and 13.38° ± 5.57° (pelvic tilt) for male tennis players, respectively; and 36.13° ± 6.69° (thoracic kyphosis), - 32.69° ± 5.06° (lumbar lordosis), 20.94° ± 5.36° (pelvic tilt) for female tennis players (p tennis players showed a frequency of 62.5% and 93.8% (p = 0.032) for neutral thoracic kyphosis, and 83.3% and 93.8% (p = 0.062) in neutral lumbar lordosis, respectively. In conclusion, due to the high percentage of neutral spinal curvatures in both male and female tennis players, to practice tennis in these levels does not alter sagittal spinal morphology in the relaxed standing posture in adolescent highly trained tennis players. Key Points This study evaluated thoracic and lumbar spinal curvatures and pelvic tilt during several postures in young highly trained tennis players. Female tennis players showed statistically significant greater anterior pelvic tilt, lumbar lordosis and lower thoracic kyphosis than male tennis players. The high percentage of neutral thoracic kyphosis and lumbar lordosis posture in both groups of young tennis players in relaxed standing

  9. The main players

    International Nuclear Information System (INIS)

    About 30 French main players in the field of energy (political parties, administrations, companies, non-governmental organizations and think-tanks) have been reported and dispatched on a chart according to their opinions following 2 axis: pro- versus anti-nuclear energy and pro- versus anti-wind power. The energy sector in France is dominated by 4 companies: EDF, GDF-Suez, Areva and Total, all are strongly pro-nuclear. All the political parties except EELV (Europe-Ecology-Les-Verts) are favourable to nuclear energy. Most non-governmental organizations are favourable to renewable energies, but the FED (Federation Environnement Durable) gathers local associations fighting the installations of wind turbines. (A.C)

  10. Body type and performance of elite cuban baseball players.

    Science.gov (United States)

    Carvajal, Wiliam; Ríos, Andrés; Echevarría, Ivis; Martínez, Miriam; Miñoso, Julio; Rodríguez, Dialvis

    2009-04-01

    adipose tissue mass values, as well as the lowest mean SLG. Catchers had similar mean weight, height, muscle mass, and adipose tissue mass values as first basemen, outfielders and infielders, but a low mean SLG similar to that of infielders. Pitchers were morphologically similar to players in all positions, but significant morphological differences were found among pitchers with different performance levels. Better-performing pitchers (≥.600 winning percentage (Wpct)) were significantly heavier and more mesomorphic than lower-performing pitchers (baseball players described in this study generally coincides with the available literature. Further research on comparative samples is needed to validate the relationship between players' body type and performance. Nevertheless, the results of this study may be applied to criteria for selection and training of high-performance baseball players in Cuba. Key words: Body composition, somatotypes, anthropometry, sports, baseball, athletic performance, sports performance. PMID:21483313

  11. PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2.

    Directory of Open Access Journals (Sweden)

    Xiao-li Li

    Full Text Available BACKGROUND: The development of diabetic angiopathy is associated with profound vascular endothelial cells (VEC dysfunction and apoptosis. Glycated low density lipoproteins (gly-LDL continuously produced in the setting of diabetic patients play an important role in causing VEC dysfunction and apoptosis. However, the underlying molecular mechanism remains largely elusive. Protein L-isoaspartyl methyltransferase (PIMT is a widely expressed protein repair enzyme by multiple cell types of arterial wall including VEC. Our previous proteomic studies showed that the expression of PIMT was significantly decreased in the aorta of diabetic rats as compared with control rats and treatment with grape seed procyanidin extracts significantly increased the PIMT expression in diabetic rats. We hypothesized that PIMT plays a critical role in gly-LDL induced VEC apoptosis; grape seed procyanidin B2 (GSPB2 protect against gly-LDL induced VEC apoptosis through PIMT regulation. METHODS AND RESULTS: HUVEC transfected negative control and PIMT siRNA were treated with or without GSPB2 (10 µmol/L for 48 h. Moreover, HUVEC of PIMT overexpression were stimulated by gly-LDL (50 µg/ml in the presence or absence of GSPB2 (10 µmol/L for 48 h. Our results showed that gly-LDL downregulated PIMT expression and PIMT overexpression or GSPB2 significantly attenuated gly-LDL induced VEC apoptosis. PIMT siRNA increased VEC apoptosis with up-regulation of p53, cytochrome c release, caspase-9 and caspase-3 activation. Mechanistically, overexpression of PIMT or GSPB2 increased the phosphorylation of ERK1/2 and GSK3β in the gly-LDL induced VEC. CONCLUSION: In summary, our study identified PIMT as a key player responsible for gly-LDL induced VEC apoptosis and GSPB2 protect against gly-LDL induced VEC apoptosis by PIMT up-regulation. Targeting PIMT including use of GSPB2 could be turned into clinical application in the fighting against diabetic vascular complications.

  12. CD44: A key player in breast cancer

    Directory of Open Access Journals (Sweden)

    M T Anand

    2014-01-01

    Full Text Available CD44 is a principal transmembrane hyluronate receptor, which acts as a hook between Extracellular Matrix and the cytoskeleton. CD44 is up regulated in breast cancer, which in turn helps in tumor progression and metastasis. There has been a lot of attention given to CD44 in recent years because of the discovery, CD44+/CD24- lineage marks breast cancer stem cells. Recent clinical and experimental findings show that CD44 is involved in the tumor associated proliferation, invasion, migration, and in many pathways involved in maintaining cancer cells which inturn are correlated with patient′s survival. All these findings make CD44 as a potential target for breast cancer treatment. The methods of literature search for this article include Pubmed, BMC cancer and other printed journal article.

  13. Brokers and key players in the internationalization of the FARC

    OpenAIRE

    Cunningham, Dan; Everton, Sean; Wilson, Greg; Padilla, Carlos; Zimmerman, Doug

    2013-01-01

    The article of records as published may be located at http://dx.doi.org/10.1080/1057610X.2013.784603 The Fuerzas Armadas Revolucionarias de Colombia (Revolutionary Armed Forces of Colombia—FARC) was originally founded to protect Colombian peasants from harsh landowner policies in exchange for food and supplies. Over time, it has evolved into an internationally connected, narco-trafficking organization that displays little concern for the peasants it once vowed to protect. In re...

  14. Key players in pancreatic cancer-stroma interaction

    DEFF Research Database (Denmark)

    Nielsen, Michael Friberg Bruun; Mortensen, Michael Bau; Detlefsen, Sönke

    2016-01-01

    Pancreatic cancer (PC) is the most aggressive type of common cancers, and in 2014, nearly 40000 patients died from the disease in the United States. Pancreatic ductal adenocarcinoma, which accounts for the majority of PC cases, is characterized by an intense stromal desmoplastic reaction...... surrounding the cancer cells. Cancer-associated fibroblasts (CAFs) are the main effector cells in the desmoplastic reaction, and pancreatic stellate cells are the most important source of CAFs. However, other important components of the PC stroma are inflammatory cells and endothelial cells. The aim...... of PC cells. However, in animal studies, experimental depletion of the desmoplastic stroma and CAFs has led to more aggressive cancers. Hence, the precise role of the tumour stroma in PC remains to be elucidated. However, it is likely that a context-dependent therapeutic modification, rather than pure...

  15. Protein phosphatase 2A, a key player in Alzheimer's disease

    Institute of Scientific and Technical Information of China (English)

    Rong LIU; Qing TIAN

    2009-01-01

    Protein phosphatase 2A (PP2A) is the pre-dominant serine/threonine phosphatase in eukaryotic cells. In the brains of patients with Alzheimer's disease (AD), decreased PP2A activities were observed, which is suggested to be involved in neurofibrillary tangle (NFT) formation, disturbed amyloid precursor protein (APP) secretion and neurodegeneration in AD brain. Based on our research and other previous findings, decreased PP2Ac level, decreased PP2A holoenzyme composition, increased level of PP2A inhibitors, increased PP2Ac Leu309 demethylation and Tyr307 phosphorylation underlie PP2A inactivation in AD. β-amyloid (Aβ) over-production, estrogen deficiency and impaired homocys-teine metabolism are the possible up-stream factors that inactivate PP2A in AD neurons. Further studies are required to disclose the role of PP2A in Alzheimer's disease.

  16. The HBZ gene, a key player in HTLV-1 pathogenesis

    Directory of Open Access Journals (Sweden)

    Green Patrick L

    2009-08-01

    Full Text Available Abstract Human T-cell leukemia virus type 1 (HTLV-1 causes adult T-cell leukemia/lymphoma (ATL and is also associated with a variety of lymphocyte-mediated diseases. The HTLV-1 basic leucine zipper (HBZ gene, found to be consistently expressed in ATL, has recently been the subject of intensive research efforts. In this review, we summarize recent findings about HBZ and discuss its roles and functions not only in the virus life cycle, but also in HTLV-1 disease pathogenesis.

  17. Biography and Discipline: Key Players in Simulation/Gaming

    Science.gov (United States)

    Kikkawa, Toshiko; Crookall, David

    2011-01-01

    This issue of S&G is devoted to people--to the gamers who have made and are making the exciting discipline of simulation gaming possible. All disciplines that hope for a bright future must record their origins and development. This is particularity the case for a field as fuzzy and interdisciplinary as simulation/gaming. The symposium dedicated to…

  18. Training Teachers as Key Players in Poverty Alleviation

    Science.gov (United States)

    Benavente, Ana; Ralambomanana, Stangeline; Mbanze, Jorge

    2008-01-01

    This article presents several questions, reflections and suggestions on pre-service and in-service teacher training that arose during the project "Curricular innovation and poverty alleviation in sub-Saharan Africa". While recognizing that the situation in the nine countries taking part in the project, and in many other countries in the southern…

  19. The new electricity market: updated views from key players

    International Nuclear Information System (INIS)

    Eight papers presented at a workshop for senior executives of utility companies has been made available in CD-ROM format. The workshop took place in Washington in January 1996. It was the fifth in a series of annual workshops jointly sponsored by the US and Canadian industry associations to explore the concerns of the electric industry. The survey of industry executives revealed growing concern about mergers, acquisitions, customer loss, falling earning, the effects of too rapid movement toward deregulation, direct access and consolidation. These, and related issues were explored, and answers were sought to the most pressing of these problems, these being how to prevent loss of industrial customers, improve earnings and revenue, and deal with stranded assets. The urgent need to cutting operating and maintenance costs, the techniques of forming strategic alliances, unbundling and mergers and acquisitions also received attention. A paper entitled 'Blueprint for customer choice' was included with the other papers for discussion purposes only

  20. Activation of Human Neutrophils by the Anti-Inflammatory Mediator Esenbeckia leiocarpa Leads to Atypical Apoptosis

    Directory of Open Access Journals (Sweden)

    Rafael de Liz

    2012-01-01

    Full Text Available Despite the fact that Esenbeckia leiocarpa, a Brazilian plant, possesses potential anti-inflammatory properties, its effect in neutrophils, key players in inflammation, has never been investigated. In this study, a crude hydroalcoholic extract (CHE was used to evaluate the potential toxic or agonistic effect of E. leiocarpa in human neutrophils. At a noncytotoxic concentration of 500 μg/mL, CHE increased actin polymerization and cell signaling events, especially p38 MAPK. Its modulatory activity on neutrophil cell apoptosis was investigated by cytology and by flow cytometry and, although CHE increased the apoptotic rate (by cytology and increased annexin-V binding, it did not, unexpectedly, increase CD16 shedding. CHE increased the degradation of the cytoskeletal proteins gelsolin and paxillin but, surprisingly, not of vimentin. The proapoptotic activity of CHE was reversed by a pan-caspase inhibitor but not by a p38 inhibitor. We conclude that CHE is a novel human neutrophil agonist that induces apoptosis by a caspase-dependent and p38-independent mechanism in an atypical fashion based on its lack of effect on CD16 shedding and vimentin degradation. Since the resolution of inflammation occurs by elimination of apoptotic neutrophils, the ability of CHE to induce neutrophil apoptosis correlates well with its anti-inflammatory properties, as previously reported.

  1. Frontal Lobe Function in Chess Players

    Directory of Open Access Journals (Sweden)

    Vahid Nejati

    2012-05-01

    Full Text Available Chess is considered as a cognitive game because of severe engagement of the mental resources during playing. The purpose of this study is evaluation of frontal lobe function of chess players with matched non-players. Wisconsin Card Sorting Test (WCST data showed no difference between the player and non-player groups in preservation error and completed categories but surprisingly showed significantly lower grade of the player group in correct response. Our data reveal that chess players dont have any preference in any stage of Stroop test. Chess players dont have any preference in selective attention, inhibition and executive cognitive function. Chess players' have lower shifting abilities than non-players.

  2. Swelling-activated ion channels: functional regulation in cell-swelling, proliferation and apoptosis

    DEFF Research Database (Denmark)

    Stutzin, A; Hoffmann, E K

    2006-01-01

    physiological control. Thus, cell volume is under a tight and dynamic control and abnormal cell volume regulation will ultimately lead to severe cellular dysfunction, including alterations in cell proliferation and cell death. This review describes the different swelling-activated ion channels that participate...... as key players in the maintenance of normal steady-state cell volume, with particular emphasis on the intracellular signalling pathways responsible for their regulation during hypotonic stress, cell proliferation and apoptosis.......Cell volume regulation is one of the most fundamental homeostatic mechanisms and essential for normal cellular function. At the same time, however, many physiological mechanisms are associated with regulatory changes in cell size meaning that the set point for cell volume regulation is under...

  3. Invertebrate Iridovirus Modulation of Apoptosis

    Institute of Scientific and Technical Information of China (English)

    Trevor Williams; Nllesh S. Chitnis; Sh(a)n L. Bilimoria

    2009-01-01

    Programmed cell death (apoptosis) is a key host response to virus infection. Viruses that can modulate host apoptotic responses are likely to gain important opportunities for transmission. Here we review recent studies that demonstrate that particles of Invertebrate iridescent virus 6 (IIV-6) (Iridoviridae, genus Iridovirus), or an IIV-6 virion protein extract, are capable of inducing apoptosis in lepidopteran and coleopteran cells, at concentrations 1000-fold lower than that required to shut-off host macromolecular synthesis. Induction of apoptosis depends on endocytosis of one or more heat-sensitive virion component(s). Studies with a JNK inh ibitor(SP600125) indicated that the JNK signaling pathway is significantly involved in apoptosis in IIV-6 infections of Choristoneurafumiferana ceils. The genome of IIV-6 codes for an inhibitor of apoptosis iap gene (193R) that encodes a protein of 208 aa with 15% identity and 28% similarity in its amino acid sequence to IAP-3 from Cydia pomonella ganulovirus (CpGV). Transcription of IIV-6 iap did not require prior DNA or protein synthesis, indicating that it is an immediate-early class gene. Transient expression and gene knockdown studies have confirmed the functional nature of the IIV-6 iap gene. We present a tentative model for IIV-6 induction and inhibition of apoptosis in insect cells and discuss the potential applications of these findings in insect pest control.

  4. Molecular signal transduction in vascular cell apoptosis

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical forces, reactive oxygen and nitrogen species, cytokines, growth factors, oxidized lipoproteins, etc., may influence apoptosis of vascular cells. The Fas/Fas ligand/caspase death-signaling pathway, Bcl-2 protein family/mitochondria, the tumor suppressive gene p53, and the proto-oncogene c-myc may be activated in atherosclerotic lesions, and mediates vascular apoptosis during the development of atherosclerosis. Abnormal expression and dysfunction of these apoptosis-regulating genes may attenuate or accelerate vascular cell apoptosis and affect the integrity and stability of atherosclerotic plaques. Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes.

  5. Psychosocial Factors Involved in Transitions from College to Postcollege Careers for Male NCAA Division-1 Basketball Players

    Science.gov (United States)

    Cummins, Paul; O'Boyle, Ian

    2015-01-01

    This article investigated the key psychosocial factors that impact upon National Collegiate Athletic Association (NCAA) Division-1 male basketball players, as they transition from college to postcollege athletic or nonathletic careers. Participants (N = 9) were current/former NCAA Division-1 basketball players. Four participants were selected…

  6. Player-character dynamics in multi-player Role Playing Games

    DEFF Research Database (Denmark)

    Tychsen, Anders; McIlwain, Doris; Brolund, Thea;

    2007-01-01

    This paper presents the results of a comprehensive empirical study of the impact of integrating complex game characters in multi-player Role Playing Games across tabletop and digital formats. Players were provided with characters that had detailed background history, personality and goals. Player...... enjoyment and player engagement with their character and no correlation between enjoyment and similarity between player and character personality. © 2007 Authors & Digital Games Research Association (DiGRA)....

  7. Psychological games of entangled players

    CERN Document Server

    Zak, Michail

    2012-01-01

    The paper introduces a new approach to theory of differential games in which entangled players try to predict and influence actions of their adversaries. The entanglement is generated be a joint probability density known by the players. Incase of complex density, its imaginary part represents a measure of uncertainty of the density distribution. The novelty of the approach is in non-Newtonian mathematical formalism thatis based upon a behavioral model of Livings. The model is quantum-inspired: it represented by a modified Madelung equation which the quantum potential is replaced by different, specially chosen "computational" potential. It consists of motor dynamics simulating actual behavior of the object, and mental dynamics representing evolution of the corresponding knowledge-based and incorporating this knowledge in the for m of information flows into the motor dynamics. Due to feedback from mental dynamics, motor dynamics attains quantum-like properties: its trajectory splits into a family of different t...

  8. Analysis of apoptosis in Caenorhabditis elegans.

    Science.gov (United States)

    Lant, Benjamin; Derry, W Brent

    2014-05-01

    The nematode worm Caenorhabditis elegans has provided researchers with a wealth of information on the molecular mechanisms controlling programmed cell death (apoptosis). Its genetic tractability, optical clarity, and relatively short lifespan are key advantages for rapid assessment of apoptosis in vivo. The use of forward and reverse genetics methodology, coupled with in vivo imaging, has provided deep insights into how a multicellular organism orchestrates the self-destruction of specific cells during development and in response to exogenous stresses. Strains of C. elegans carrying mutations in the core elements of the apoptotic pathway, or in tissue-specific regulators of apoptosis, can be used for genetic analyses to reveal conserved mechanisms by which apoptosis is regulated in the somatic and reproductive (germline) tissue. Here we present an introduction to the study of apoptosis in C. elegans, including current techniques for visualization, analysis, and screening. PMID:24786497

  9. 14-3-3 zeta is a molecular target in guggulsterone induced apoptosis in Head and Neck cancer cells

    International Nuclear Information System (INIS)

    The five-year survival rates for head and neck squamous cell carcinoma (HNSCC) patients are less than 50%, and the prognosis has not improved, despite advancements in standard multi-modality therapies. Hence major emphasis is being laid on identification of novel molecular targets and development of multi-targeted therapies. 14-3-3 zeta, a multifunctional phospho-serine/phospho-threonine binding protein, is emerging as an effector of pro-survival signaling by binding to several proteins involved in apoptosis (Bad, FKHRL1 and ASK1) and may serve as an appropriate target for head and neck cancer therapy. Herein, we determined effect of guggulsterone (GS), a farnesoid X receptor antagonist, on 14-3-3 zeta associated molecular pathways for abrogation of apoptosis in head and neck cancer cells. Head and neck cancer cells were treated with guggulsterone (GS). Effect of GS-treatment was evaluated using cell viability (MTT) assay and apoptosis was verified by annexin V, DNA fragmentation and M30 CytoDeath antibody assay. Mechanism of GS-induced apoptosis was determined by western blotting and co-IP assays using specific antibodies. Using in vitro models of head and neck cancer, we showed 14-3-3 zeta as a key player regulating apoptosis in GS treated SCC4 cells. Treatment with GS releases BAD from the inhibitory action of 14-3-3 zeta in proliferating HNSCC cells by activating protein phosphatase 2A (PP2A). These events initiate the intrinsic mitochondrial pathway of apoptosis, as revealed by increased levels of cytochrome c in cytoplasmic extracts of GS-treated SCC4 cells. In addition, GS treatment significantly reduced the expression of anti-apoptotic proteins, Bcl-2, xIAP, Mcl1, survivin, cyclin D1 and c-myc, thus committing cells to apoptosis. These events were followed by activation of caspase 9, caspase 8 and caspase 3 leading to cleavage of its downstream target, poly-ADP-ribose phosphate (PARP). GS targets 14-3-3 zeta associated cellular pathways for reducing

  10. Vitamin D Deficiency Among Professional Basketball Players

    Science.gov (United States)

    Fishman, Matthew P.; Lombardo, Stephen J.; Kharrazi, F. Daniel

    2016-01-01

    Background: Vitamin D plays an important role in several systems of the human body. Various studies have linked vitamin D deficiency to stress and insufficiency fractures, muscle recovery and function, and athletic performance. The prevalence of vitamin D deficiency in the elite athletic population has not been extensively studied, and very few reports exist among professional athletes. Hypothesis: There is a high prevalence of vitamin D deficiency or insufficiency among players attending the National Basketball Association (NBA) Combine. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This is a retrospective review of data previously collected as part of the routine medical evaluation of players in the NBA Combines from 2009 through 2013. Player parameters evaluated were height, weight, body mass index (BMI), and vitamin D level. Statistical analysis using t tests and analysis of variance was used to detect any correlation between the player parameters and vitamin D level. Vitamin D levels were categorized as deficient (32 ng/mL). Results: After institutional review board approval was submitted to the NBA, the NBA released deidentified data on 279 players who participated in the combines from 2009 through 2013. There were 90 players (32.3%) who were deficient, 131 players (47.0%) who were insufficient, and 58 players (20.8%) who were sufficient. A total of 221 players (79.3%) were either vitamin D deficient or insufficient. Among all players included, the average vitamin D level was 25.6 ± 10.2 ng/mL. Among the players who were deficient, insufficient, and sufficient, the average vitamin D levels were 16.1 ± 2.1 ng/mL, 25.0 ± 3.4 ng/mL, and 41.6 ± 8.6 ng/mL, respectively. Player height and weight were significantly increased in vitamin D–sufficient players compared with players who were not sufficient (P = .0008 and .009, respectively). Player age and BMI did not significantly differ depending on vitamin D status (P = .15 and .77

  11. β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway

    Directory of Open Access Journals (Sweden)

    Zhang Dong

    2011-11-01

    Full Text Available Abstract Background Smoking and stress, pancreatic cancer (PanCa risk factors, stimulate nitrosamine 4-(methylnitrosamino-1-(3-pyridyl-1-butanone (NNK and catecholamines production respectively. NNK and catecholamine bind the β-adrenoceptors and induce PanCa cell proliferation; and we have previously suggested that β-adrenergic antagonists may suppress proliferation and invasion and stimulate apoptosis in PanCa. To clarify the mechanism of apoptosis induced by β2-adrenergic antagonist, we hypothesize that blockage of the β2-adrenoceptor could induce G1/S phase arrest and apoptosis and Ras may be a key player in PanCa cells. Results The β1 and β2-adrenoceptor proteins were detected on the cell surface of PanCa cells from pancreatic carcinoma specimen samples by immunohistochemistry. The β2-adrenergic antagonist ICI118,551 significantly induced G1/S phase arrest and apoptosis compared with the β1-adrenergic antagonist metoprolol, which was determined by the flow cytometry assay. β2-adrenergic antagonist therapy significantly suppressed the expression of extracellular signal-regulated kinase, Akt, Bcl-2, cyclin D1, and cyclin E and induced the activation of caspase-3, caspase-9 and Bax by Western blotting. Additionally, the β2-adrenergic antagonist reduced the activation of NFκB in vitro cultured PanCa cells. Conclusions The blockage of β2-adrenoceptor markedly induced PanCa cells to arrest at G1/S phase and consequently resulted in cell death, which is possibly due to that the blockage of β2-adrenoceptor inhibited NFκB, extracellular signal-regulated kinase, and Akt pathways. Therefore, their upstream molecule Ras may be a key factor in the β2-adrenoceptor antagonist induced G1/S phase arrest and apoptosis in PanCa cells. The new pathway discovered in this study may provide an effective therapeutic strategy for PanCa.

  12. Stress fractures in elite male football players

    OpenAIRE

    Ekstrand, Jan; Torstveit, M. K.

    2012-01-01

    The objective was to investigate the incidence, type and distribution of stress fractures in professional male football players. Fifty-four football teams, comprising 2379 players, were followed prospectively for 189 team seasons during the years 2001–2009. Team medical staff recorded individual player exposure and time-loss injuries. The first team squads of 24 clubs selected by UEFA as belonging to the 50 best European teams, 15 teams of the Swedish Super League and 15 teams playing their h...

  13. Executive Functioning in Highly Talented Soccer Players

    OpenAIRE

    Lot Verburgh; Scherder, Erik J. A.; Van Lange, Paul A. M.; Jaap Oosterlaan

    2014-01-01

    Executive functions might be important for successful performance in sports, particularly in team sports requiring quick anticipation and adaptation to continuously changing situations in the field. The executive functions motor inhibition, attention and visuospatial working memory were examined in highly talented soccer players. Eighty-four highly talented youth soccer players (mean age 11.9), and forty-two age-matched amateur soccer players (mean age 11.8) in the age range 8 to 16 years per...

  14. Chess Player by Co-Evolutionary Algorithm

    OpenAIRE

    Ramos, Nuno; Salgado, Sergio; Rosa, Agostinho C

    2016-01-01

    A co-evolutionary algorithm (CA) based chess player is presented. Implementation details of the algorithms, namely coding, population, variation operators are described. The alpha-beta or mini-max like behaviour of the player is achieved through two competitive or cooperative populations. Special attention is given to the fitness function evaluation (the heart of the solution). Test results on algorithms vs. algorithms or human player is provided.

  15. Chess players' fame versus their merit

    CERN Document Server

    Simkin, M V

    2015-01-01

    We investigate a pool of international chess title holders born between 1901 and 1943. Using Elo ratings we compute for every player his expected score in a game with a randomly selected player from the pool. We use this figure as player's merit. We measure players' fame as the number of Google hits. The correlation between fame and merit is 0.38. At the same time the correlation between the logarithm of fame and merit is 0.61. This suggests that fame grows exponentially with merit.

  16. New players in the pathogenesis of focal segmental glomerulosclerosis.

    Science.gov (United States)

    Schell, Christoph; Huber, Tobias B

    2012-09-01

    Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular disorder causing end-stage renal disease. Since the first description of this clinicopathological entity in the early 1930s, various studies have identified numerous underlying pathogenetic mechanisms. Nevertheless, FSGS is still a complex, only partially understood and in its classification sometimes confusing disease. A unifying pathophysiological concept has not been identified and might not even exist. However, research efforts of past decades identified FSGS as a podocytopathy with several podocyte molecules being key players in the development and the course of FSGS. Podocytes are crucially involved in the formation of the glomerular barrier and any assault on their delicate physiological balance and architecture can result in the development of proteinuria. The following review article will introduce most recent examples identifying novel players in the complex pathogenesis of FSGS. PMID:22767631

  17. Neuromuscular Risk Factors for Knee and Ankle Ligament Injuries in Male Youth Soccer Players.

    Science.gov (United States)

    Read, Paul J; Oliver, Jon L; De Ste Croix, Mark B A; Myer, Gregory D; Lloyd, Rhodri S

    2016-08-01

    Injuries reported in male youth soccer players most commonly occur in the lower extremities, and include a high proportion of ligament sprains at the ankle and knee with a lower proportion of overuse injuries. There is currently a paucity of available literature that examines age- and sex-specific injury risk factors for such injuries within youth soccer players. Epidemiological data have reported movements that lead to non-contact ligament injury include running, twisting and turning, over-reaching and landing. Altered neuromuscular control during these actions has been suggested as a key mechanism in females and adult populations; however, data available in male soccer players is sparse. The focus of this article is to review the available literature and elucidate prevalent risk factors pertaining to male youth soccer players which may contribute to their relative risk of injury. PMID:26856339

  18. Anthropometric Characteristics of Columbia, South Carolina, Youth Baseball Players and Dixie Youth World Series Players

    Science.gov (United States)

    French, Karen E.; Spurgeon, John H.; Nevett, Michael E.

    2007-01-01

    The purpose of this study was to compare measures of body size in two samples of youth baseball players with normative data from the United States National Center for Health Statistics (NCHS) growth charts. One sample of youth baseball players participated in a local little league. The second sample of youth baseball players were members of eight…

  19. Exercise performance of professional football players.

    Science.gov (United States)

    Shields, C L; Whitney, F E; Zomar, V D

    1984-01-01

    With the likely hypothesis that the degree to which a football player is physically suited to his position will determine his value as a player, we attempted to describe the characteristics of a given player and position and, from that, to determine the characteristics that make up a first class player in that position. Over a 4-year period 167 football players were examined at the National Athletic Health Institute, Inglewood, California, and grouped according to playing position and class. Position groups were: 1, linemen; 2, linebackers and tight ends; 3, running backs, quarterbacks and kickers; and 4, wide receivers and defensive backs. Classes were: I, rookies (nonstarters); II, veterans (nonstarters); and III, starters (veterans and an occasional rookie). Testing was in two phases, body characteristics and direct measurement of body function. All testing was done in connection with the preseason physical exam. Significant differences were found when data were analyzed by position. Position 1 players were taller, heavier, and had a higher percentage of body fat than players at other positions. These values decreased from Position 1 to Position 4. In terms of cardiovascular fitness the opposite trend was seen. Strength measures were also specific to given position groups. While few differences were seen when data were analyzed by class, one interesting finding was that Class III players (starters) were not only the oldest, but also had the highest level of cardiovascular fitness. Our conclusion is that while size, strength, and endurance are obvious advantages for the successful regular player, there is an unmeasurable quality reflected in the playing ability of the veteran player that is not easily identified in the beginning player. PMID:6507716

  20. Sphingosine in apoptosis signaling.

    Science.gov (United States)

    Cuvillier, Olivier

    2002-12-30

    The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a sphingosine kinase, has been involved in stimulating cell growth and inhibiting apoptosis. As the phosphorylation of sphingosine diminishes apoptosis, while dephosphorylation of sphingosine 1-phosphate potentiates it, the role of sphingosine as a messenger of apoptosis is of importance. Herein, the effects of sphingosine on diverse signaling pathways implicated in the apoptotic process are reviewed. PMID:12531549

  1. [Almaty club "KAIRAT" young football players' health].

    Science.gov (United States)

    Kausova, G K; Karabaeva, A I

    2013-10-01

    The aim of the investigation was to study young football players' health. The study was conducted on 161 football players (mean age 12.3) of six children football teams of Almaty club "KAIRAT" during the competition period. It was found that 55,5% of the football players are practically healthy; 18,6% of football players have iron deficiency anemia. 32,6% of football players have caries; 5% of football players have problems of cardiopulmonary system. Investigation reveal, that in a junior sportsman was body weigh surging with downtrend during contest, testify to portability of aerobic load and in childhood unconformable of metabolism' level. This tendency was retain also in the oldest sportsman, this testify to most emulative aerobic load in comparison with junior sportsman. According as the age increases it is emulative load's extension and free occurrence of body weigh subsequent reduction but in the oldest sportsman with prevalence macrosomia. Concurrently with improvement of the anthropometric profile as far as increase of age in soccer players it is forming of a high training level. In spite of lowering of energy resources and the physical load organism's adaptation there are these phenomena. According as the age increases in a soccer player's performance of cardiac and respiratory system are improved. PMID:24214593

  2. Bargaining with Many Players: A Limit Result

    OpenAIRE

    Klaus Kultti; Hannu Vartiainen

    2008-01-01

    We provide a simple characterization of the stationary subgame perfect equilibrium of an alternating offers bargaining game when the number of players increases without a limit. Core convergence literature is emulated by increasing the number of players by replication. The limit allocation is interpreted in terms of Walrasian market for being the first proposer.

  3. The potential risk of personal stereo players

    DEFF Research Database (Denmark)

    Hammershøi, Dorte; Ordoñez, Rodrigo Pizarro; Reuter, Karen

    2010-01-01

    The technological development within personal stereo systems,such as MP3 players, e. g. iPods, has changed music listening habits from home entertainment to everyday and everywhere use. The technology has developed considerably, since the introduction of cassette players and CD walkmen. High-leve...

  4. Fault Predictive Control of Compact Disk Players

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Wickerhauser, Mladen Victor

    Optical disc players such as CD-players have problems playing certain discs with surface faults like scratches and fingerprints. The problem is to be found in the servo controller which positions the optical pick-up, such that the laser beam is focused on the information track. A scheme handling...

  5. Computing Decoupled Residuals for Compact Disc Players

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Stoustrup, Jakob; Andersen, Palle;

    2006-01-01

    pair of residuals generated by Compact Disc Player. However, these residuals depend on the performance of position servos in the Compact Disc Player. In other publications of the same authors a pair of decoupled residuals is derived. However, the computation of these alternative residuals has been...

  6. Injuries in racket sports among Slovenian players.

    Science.gov (United States)

    Kondric, Miran; Matković, Branka R; Furjan-Mandić, Gordana; Hadzić, Vedran; Dervisević, Edvin

    2011-06-01

    On the sample of 83 top Slovenian athletes we have studied the frequency of injuries among table tennis, tennis and badminton players, types of injuries and severity of injuries--the latter based on data of players absences from training and/or competition processes. The most liable parts to injuries are shoulder girdle (17.27%), spine (16.55%) and ankle (15.83%), while foot (10.07%) and wrist (12.23%) are slightly less liable to injuries. The most frequent injuries in racket sports pertain to muscle tissues. According to this data, the majority of injuries occur halfway through a training session or a competition event, mostly during a competition season. The injuries primarily pertain to muscle tissues; these are followed by joint and tendon injuries. There are no differences between male and female players. Compared to other racket sports players, table tennis players suffer from fewer injuries. PMID:21755712

  7. Stochastic modeling of p53-regulated apoptosis upon radiation damage

    CERN Document Server

    Bhatt, Divesh; Bahar, Ivet

    2011-01-01

    We develop and study the evolution of a model of radiation induced apoptosis in cells using stochastic simulations, and identified key protein targets for effective mitigation of radiation damage. We identified several key proteins associated with cellular apoptosis using an extensive literature survey. In particular, we focus on the p53 transcription dependent and p53 transcription independent pathways for mitochondrial apoptosis. Our model reproduces known p53 oscillations following radiation damage. The key, experimentally testable hypotheses that we generate are - inhibition of PUMA is an effective strategy for mitigation of radiation damage if the treatment is administered immediately, at later stages following radiation damage, inhibition of tBid is more effective.

  8. Executive functioning in highly talented soccer players.

    Directory of Open Access Journals (Sweden)

    Lot Verburgh

    Full Text Available Executive functions might be important for successful performance in sports, particularly in team sports requiring quick anticipation and adaptation to continuously changing situations in the field. The executive functions motor inhibition, attention and visuospatial working memory were examined in highly talented soccer players. Eighty-four highly talented youth soccer players (mean age 11.9, and forty-two age-matched amateur soccer players (mean age 11.8 in the age range 8 to 16 years performed a Stop Signal task (motor inhibition, the Attention Network Test (alerting, orienting, and executive attention and a visuospatial working memory task. The highly talented soccer players followed the talent development program of the youth academy of a professional soccer club and played at the highest national soccer competition for their age. The amateur soccer players played at a regular soccer club in the same geographical region as the highly talented soccer players and play in a regular regional soccer competition. Group differences were tested using analyses of variance. The highly talented group showed superior motor inhibition as measured by stop signal reaction time (SSRT on the Stop Signal task and a larger alerting effect on the Attention Network Test, indicating an enhanced ability to attain and maintain an alert state. No group differences were found for orienting and executive attention and visuospatial working memory. A logistic regression model with group (highly talented or amateur as dependent variable and executive function measures that significantly distinguished between groups as predictors showed that these measures differentiated highly talented soccer players from amateur soccer players with 89% accuracy. Highly talented youth soccer players outperform youth amateur players on suppressing ongoing motor responses and on the ability to attain and maintain an alert state; both may be essential for success in soccer.

  9. Executive functioning in highly talented soccer players.

    Science.gov (United States)

    Verburgh, Lot; Scherder, Erik J A; van Lange, Paul A M; Oosterlaan, Jaap

    2014-01-01

    Executive functions might be important for successful performance in sports, particularly in team sports requiring quick anticipation and adaptation to continuously changing situations in the field. The executive functions motor inhibition, attention and visuospatial working memory were examined in highly talented soccer players. Eighty-four highly talented youth soccer players (mean age 11.9), and forty-two age-matched amateur soccer players (mean age 11.8) in the age range 8 to 16 years performed a Stop Signal task (motor inhibition), the Attention Network Test (alerting, orienting, and executive attention) and a visuospatial working memory task. The highly talented soccer players followed the talent development program of the youth academy of a professional soccer club and played at the highest national soccer competition for their age. The amateur soccer players played at a regular soccer club in the same geographical region as the highly talented soccer players and play in a regular regional soccer competition. Group differences were tested using analyses of variance. The highly talented group showed superior motor inhibition as measured by stop signal reaction time (SSRT) on the Stop Signal task and a larger alerting effect on the Attention Network Test, indicating an enhanced ability to attain and maintain an alert state. No group differences were found for orienting and executive attention and visuospatial working memory. A logistic regression model with group (highly talented or amateur) as dependent variable and executive function measures that significantly distinguished between groups as predictors showed that these measures differentiated highly talented soccer players from amateur soccer players with 89% accuracy. Highly talented youth soccer players outperform youth amateur players on suppressing ongoing motor responses and on the ability to attain and maintain an alert state; both may be essential for success in soccer. PMID:24632735

  10. [The comeback of mitochondria in Drosophila apoptosis].

    Science.gov (United States)

    Clavier, Amandine; Rincheval-Arnold, Aurore; Mignotte, Bernard; Guénal, Isabelle

    2016-05-01

    The role of the mitochondrion in mammalian cell apoptosis has been established since the mid-1990s. However, the importance of this organelle in non-mammalian apoptosis has long been regarded as minor, notably because of the absence of a crucial role for cytochrome c in caspase activation. Recent results indicate that the control of caspase activation and apoptosis in Drosophila cell death occurs at the mitochondrial level. Numerous proteins that appear key for Drosophila apoptosis regulation constitutively or transiently bind to mitochondria. They participate in the cell death process at different levels such as degradation of an IAP caspase inhibitor, production of mitochondrial reactive oxygen species or stimulation of the mitochondrial fission machinery. The aim of this review is to take stock of these events that might have their counterpart in humans. PMID:27225920

  11. Epigenetics: an emerging player in gastric cancer.

    Science.gov (United States)

    Kang, Changwon; Song, Ji-Joon; Lee, Jaeok; Kim, Mi Young

    2014-06-01

    Cancers, like other diseases, arise from gene mutations and/or altered gene expression, which eventually cause dysregulation of numerous proteins and noncoding RNAs. Changes in gene expression, i.e., upregulation of oncogenes and/or downregulation of tumor suppressor genes, can be generated not only by genetic and environmental factors but also by epigenetic factors, which are inheritable but nongenetic modifications of cellular chromosome components. Identification of the factors that contribute to individual cancers is a prerequisite to a full understanding of cancer mechanisms and the development of customized cancer therapies. The search for genetic and environmental factors has a long history in cancer research, but epigenetic factors only recently began to be associated with cancer formation, progression, and metastasis. Epigenetic alterations of chromatin include DNA methylation and histone modifications, which can affect gene-expression profiles. Recent studies have revealed diverse mechanisms by which chromatin modifiers, including writers, erasers and readers of the aforementioned modifications, contribute to the formation and progression of cancer. Furthermore, functional RNAs, such as microRNAs and long noncoding RNAs, have also been identified as key players in these processes. This review highlights recent findings concerning the epigenetic alterations associated with cancers, especially gastric cancer. PMID:24914365

  12. The players on the European gas market - 2008 edition

    International Nuclear Information System (INIS)

    In a context of growing dependence on extra-European sources, a growth potential in gas use for power generation and the acceleration of the liberalization process, the 2008 Edition of 'The Players on the European Gas Market' offers a unique detailed review of the positioning of players in both the upstream (production, reserves) and downstream (wholesale and retail supply) sectors of the gas chain. This 140-pages report, includes 55 tables and 29 figures, and presents an in-depth description of the European gas industry by country. The Survey 'The Players on the European Gas Market' provides: - The analysis of new upstream areas and production growth prospects, - Company rankings in terms of reserve and production volumes, - The complete overview of the whole European gas market (market characteristics, supply sources, consuming outlets, effective competition), - Strategies and key facts of the wholesale suppliers to Europe, - An in-depth review of national market structures, - The detailed positioning and analysis of national market power of the numerous companies involved in gas supply

  13. Sports teams as complex adaptive systems: manipulating player numbers shapes behaviours during football small-sided games.

    Science.gov (United States)

    Silva, Pedro; Vilar, Luís; Davids, Keith; Araújo, Duarte; Garganta, Júlio

    2016-01-01

    Small-sided and conditioned games (SSCGs) in sport have been modelled as complex adaptive systems. Research has shown that the relative space per player (RSP) formulated in SSCGs can impact on emergent tactical behaviours. In this study we adopted a systems orientation to analyse how different RSP values, obtained through manipulations of player numbers, influenced four measures of interpersonal coordination observed during performance in SSCGs. For this purpose we calculated positional data (GPS 15 Hz) from ten U-15 football players performing in three SSCGs varying in player numbers (3v3, 4v4 and 5v5). Key measures of SSCG system behaviours included values of (1) players' dispersion, (2) teams' separateness, (3) coupling strength and time delays between participants' emerging movements, respectively. Results showed that values of participants' dispersion increased, but the teams' separateness remained identical across treatments. Coupling strength and time delay also showed consistent values across SSCGs. These results exemplified how complex adaptive systems, like football teams, can harness inherent degeneracy to maintain similar team spatial-temporal relations with opponents through changes in inter-individual coordination modes (i.e., players' dispersion). The results imply that different team behaviours might emerge at different ratios of field dimension/player numbers. Therefore, sport pedagogists should carefully evaluate the effects of changing RSP in SSCGs as a way of promoting increased or decreased pressure on players. PMID:27026887

  14. The antioxidant protein PARK7 plays an important role in cell resistance to Cisplatin-induced apoptosis in case of clear cell renal cell carcinoma.

    Science.gov (United States)

    Trivedi, Rachana; Dihazi, Gry H; Eltoweissy, Marwa; Mishra, Durga P; Mueller, Gerhard A; Dihazi, Hassan

    2016-08-01

    Clear cell renal cell carcinoma (ccRCC) is the most malignant tumor in the adult kidney. Many factors are responsible for the development and progression of this tumor. Increased reactive oxygen species accumulation and altered redox status have been observed in cancer cells and this biochemical property of cancer cells can be exploited for therapeutic benefits. In earlier work we identified and characterize Protein DJ-1 (PARK7) as an oxidative stress squevenger in renal cells exposed to oxidative stress. To investigate whether the PARK7 or other oxidative stress proteins play a role in the renal cell carcinoma and its sensitivity or resistance to cytostatic drug treatment, differential proteomics analysis was performed with a cell model for clear cell renal carcinoma (Caki-2 and A498). Caki-2 cells were treated with cisplatin and differentially expressed proteins were investigated. The cisplatin treatment resulted in an increase in reactive oxygen species accumulation and ultimately apoptosis of Caki-2 and A498 cells. In parallel, the apoptotic effect was accompanied by a significant downregulation of antioxidant proteins especially PARK7. Knockdown of PARK7 using siRNA and overexpression using plasmid highlights the role of PARK7 as a key player in renal cell carcinoma response to cisplatin induced apoptosis. Overexpression of PARK7 resulted in significant decrease in apoptosis, whereas knockdown of the protein was accompanied by an increase in apoptosis in Caki-2 and A498 cells treated with cisplatin. These results highlights for the first time the important role of PARK7 in cisplatin induced apoptosis in clear renal cell carcinoma cells. PMID:27112662

  15. Examining Player Anger in World of Warcraft

    Science.gov (United States)

    Barnett, Jane; Coulson, Mark; Foreman, Nigel

    This questionnaire study of the sources of anger in World of Warcraft applies classical quantitative measurement scale construction to a new problem, generating a host of questionnaire items that could find use in future studies, and identifying four major categories of events that cause negative effect among players. First, 33 players provided examples of in-game scenarios that had made them angry, and their responses were culled to create a 93-item battery rated by hundreds of player respondents in terms of anger intensity and anger frequency. An iterative process of factor analysis and scale reliability assessment led to a 28-item instrument measuring four anger-provoking factors: Raids/Instances, Griefers, Perceived Time Wasting, and Anti-social Players. These anger-causing scenarios were then illustrated by concrete examples from player and researcher experiences in World of Warcraft. One striking finding is that players become angry at other players' negative behavior, regardless of whether that behavior was intended to harm.

  16. Physiological characteristics of international female soccer players.

    Science.gov (United States)

    Manson, Sarah A; Brughelli, Matt; Harris, Nigel K

    2014-02-01

    The purpose of this study was to investigate the physiological characteristics of Fédération Internationale de Football Association (FIFA) eligible international female soccer players aged 14-36 years and to determine if measures were significantly different for players selected (i.e., starters) to the starting line up for an FIFA tournament as compared with those not selected (i.e., nonstarters). Fifty-one (N = 18 Under 17; N = 18 Under 20; N = 15 Senior) international female soccer players participated in this study. The subjects underwent measurements of anthropometry (height and body mass), lower body strength (isokinetic testing), sprint kinetics and kinematics (nonmotorized treadmill), leg power (unilateral jumping), and maximal aerobic velocity (30:15 intermittent fitness test) during the final preparatory stage for an FIFA event. Outcomes of the age group data indicate that differences in physiological capacities are evident for the Under 17 players as compared with those for the Under 20 and Senior capped international players, suggesting a plateau in the acquisition of physical qualities as players mature. Starters tended to be faster (effect size [ES] = 0.55-1.0, p soccer players. PMID:24476742

  17. Modelling Virtual Camera Behaviour Through Player Gaze

    DEFF Research Database (Denmark)

    Picardi, Andrea; Burelli, Paolo; Yannakakis, Georgios N.

    2012-01-01

    In a three-dimensional virtual environment, aspects such as narrative and interaction largely depend on the placement and animation of the virtual camera. Therefore, virtual camera control plays a critical role in player experience and, thereby, in the overall quality of a computer game. Both game...... on the relationship between virtual camera, game-play and player behaviour. We run a game user experiment to shed some light on this relationship and identify relevant dif- ferences between camera behaviours through different game sessions, playing behaviours and player gaze patterns. Re- sults show that users can...... be efficiently profiled in dissimilar clusters according to camera control as part of their game- play behaviour....

  18. Apoptosis in the Retina

    OpenAIRE

    Crisanti, Patricia; Lecain, Eric; Omri, Boubaker

    2007-01-01

    Retinal degenerations are a common cause of blindness in Western countries. Despite various origins of retinal degeneration it is well recognised that. Apoptosis is the final pathway of photoreceptor neuron cell death in these diseases. So that Ivana Scovassi presents the historical development of our knowledge in: apoptosis, its difference with other forms of cell death as necrosis and analyses when and how apoptosis arises, discussing also the molecular markers in this form of cell death. T...

  19. Longitudinal study of repeated sprint performance in youth soccer players of contrasting skeletal maturity status.

    Science.gov (United States)

    Valente-Dos-Santos, João; Coelho-E-Silva, Manuel J; Severino, Vítor; Duarte, João; Martins, Raúl S; Figueiredo, António J; Seabra, André T; Philippaerts, Renaat M; Cumming, Sean P; Elferink-Gemser, Marije; Malina, Robert M

    2012-01-01

    The purpose of the study was to evaluate the developmental changes in performance in a repeated-sprint ability (RSA) test in young soccer players of contrasting maturity status. A total of 83 regional level Portuguese youth soccer players, aged 11-13 years at baseline was assessed annually. Stature, body mass, 7x34.2-m sprint protocol (25-s active recovery), 20-m multi-stage continuous shuttle endurance run and counter-movement jump (CMJ) without the use of the arms were measured. Fat-free mass (FFM) was determined by age and gender-specific formulas. Developmental changes in total sprint time across ages were predicted using multilevel modeling. Corresponding measurements were performed on an independent cross-sectional subsample of 52 youth soccer players 11-17 years to evaluate the predictive model. CA, CA(2), maturational status (SA-CA), body size (mass and stature), FFM, aerobic endurance, lower limb explosive strength and annual volume training significantly improved the statistical fit of the RSA multilevel model. In 'late' maturing athletes, the best model for predicting change in RSA was expressed by the following equation: 86.54 - 2.87 x CA + 0.05 x CA(2) - 0.25 x FFM + 0.15 x body mass + 0.05 x stature - 0.05 x aerobic endurance - 0.09 x lower limb explosive strength - 0.01 x annual volume training. The best fitting models for players who were 'on time' and 'early' maturing were identical to the best model for late maturing players, less 0.64 seconds and 1.74 seconds, respectively. Multilevel modeling provided performance curves that permitted the prediction of individual RSA performance across adolescent years in regional level soccer players. Key pointsRepeated-sprint ability tests are a valuable sport-specific field test of sprint performance in youth soccer players. Here, the test had reasonable reliability and can be useful to trainers and coaches in the assessment of young athletes and in monitoring changes over time.The total sprint time of youth

  20. Distributed Certificateless Key Encapsulation Mechanism Secure Against the Adaptive Adversary

    Institute of Scientific and Technical Information of China (English)

    LONG Yu; LI Xiang-xue; CHEN Ke-fei; HONG Xuan

    2009-01-01

    This paper proposes an adaptively secure solution to certificateless distributed key encapsulation mechanism from pairings by using Canetti's adaptive secure key generation scheme based on discrete logarithm. The proposed scheme can withstand adaptive attackers that can choose players for corruption at any time during the run of the protocol, and this kind of attack is powerful and realistic. In contrast, all previously presented threshold certificateless public key cryptosystems are proven secure against the more idealized static adversaries only. They choose and fix the subset of target players before running the protocol. We also prove security of this scheme in the random oracle model.

  1. Does Education Matter? Major League Baseball Players and Longevity

    Science.gov (United States)

    Kalist, David E.; Peng, Yingwei

    2007-01-01

    The authors used duration analysis to examine the longevity of Major League Baseball players. Using data on players who were born between 1945 and 1964, the authors found that the hazard rate of death for players who only attended high school was almost 2.0 times higher than those players who attended a 4-year university, evidence that the…

  2. Major League Baseball Players' Life Expectancies.

    Science.gov (United States)

    Saint Onge, Jarron M; Rogers, Richard G; Krueger, Patrick M

    2008-07-17

    OBJECTIVE: We examine the importance of anthropometric and performance measures, and age, period, and cohort effects in explaining life expectancies among major league baseball (MLB) players over the past century. METHODS: We use discrete time hazard models to calculate life tables with covariates with data from Total Baseball, a rich source of information on all players who played in the major league. RESULTS: Compared to 20-year-old U.S. males, MLB players can expect almost five additional years of life. Height, weight, handedness, and player ratings are unassociated with the risk of death in this population of highly active and successful adults. Career length is inversely associated with the risk of death, likely because those who play longer gain additional incomes, physical fitness, and training. CONCLUSIONS: Our results indicate improvements in life expectancies with time for all age groups and indicate possible improvements in longevity in the general U.S. population. PMID:19756205

  3. Video Player Keyboard Shortcuts: MedlinePlus

    Science.gov (United States)

    ... of this page: https://medlineplus.gov/hotkeys.html Video Player Keyboard Shortcuts To use the sharing features ... of accessible keyboard shortcuts for our latest Health videos on the MedlinePlus site. These shortcuts allow you ...

  4. APOPTOSIS, OXIDATIVE STRESS AND NEUROLOGICAL DISEASE

    Directory of Open Access Journals (Sweden)

    P. Formichi

    2012-01-01

    Full Text Available Apoptosis is a selective cell deletion process which requires the triggering of a specific cell death programme. Two main pathways determining cell death have been identified: the extrinsic or receptor-mediated pathway, activated in response to extracellular pro-apoptotic signals, and the intrinsic pathway, activated by extracellular receptor-independent stimuli or by intracellular insults, such as DNA damage and oxidative stress. All these stress signals are integrated by mitochondria which participate by releasing the main effectors of this process: a family of aspartic-specific proteases known as caspase. Today there is much evidence to suggest that deregulation of apoptosis is a key feature of many neurodegenerative disease. Our group sought cell models for the study of apoptotic pathways and for the evaluation of the role of apoptosis in specific neurodegenerative diseases. We focused on oxidative stress-induced apoptosis and activation of the intrinsic mitochondrial pathway. In our in-vitro model, lymphocytes from patients and control subjects were cultured both in basal conditions and with 2-deoxy-D-ribose (dRib, a reducing sugar which induces apoptosis through oxidative stress. In the last ten years, we evaluated the role of apoptosis in the pathogenesis of several neurodegenerative diseases: Ataxiatelangiectasia,Rett syndrome, Mitochondrial disease, Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL. Here we report some of our ongoing and recently published articles.

  5. Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation

    International Nuclear Information System (INIS)

    Coagulation Factor (F)Xa is a serine protease that plays a crucial role during blood coagulation by converting prothrombin into active thrombin. Recently, however, it emerged that besides this role in coagulation, FXa induces intracellular signaling leading to different cellular effects. Here, we show that coagulation factor (F)Xa drives tumor cells of epithelial origin, but not endothelial cells or monocytes, into apoptosis, whereas it even enhances fibroblast survival. FXa signals through the protease activated receptor (PAR)-1 to activate extracellular-signal regulated kinase (ERK) 1/2 and p38. This activation is associated with phosphorylation of the transcription factor CREB, and in tumor cells with up-regulation of the BH3-only pro-apoptotic protein Bim, leading to caspase-3 cleavage, the main hallmark of apoptosis. Transfection of tumor cells with dominant negative forms of CREB or siRNA for either PAR-1, Bim, ERK1 and/or p38 inhibited the pro-apoptotic effect of FXa. In fibroblasts, FXa-induced PAR-1 activation leads to down-regulation of Bim and pre-treatment with PAR-1 or Bim siRNA abolishes proliferation. We thus provide evidence that beyond its role in blood coagulation, FXa plays a key role in cellular processes in which Bim is the central player in determining cell survival

  6. Vapor of volatile oils from Litsea cubeba seed induces apoptosis and causes cell cycle arrest in lung cancer cells.

    Directory of Open Access Journals (Sweden)

    Soma Seal

    Full Text Available Non-small cell lung carcinoma (NSCLC is a major killer in cancer related human death. Its therapeutic intervention requires superior efficient molecule(s as it often becomes resistant to present chemotherapy options. Here we report that vapor of volatile oil compounds obtained from Litsea cubeba seeds killed human NSCLC cells, A549, through the induction of apoptosis and cell cycle arrest. Vapor generated from the combined oils (VCO deactivated Akt, a key player in cancer cell survival and proliferation. Interestingly VCO dephosphorylated Akt at both Ser(473 and Thr(308; through the suppression of mTOR and pPDK1 respectively. As a consequence of this, diminished phosphorylation of Bad occurred along with the decreased Bcl-xL expression. This subsequently enhanced Bax levels permitting the release of mitochondrial cytochrome c into the cytosol which concomitantly activated caspase 9 and caspase 3 resulting apoptotic cell death. Impairment of Akt activation by VCO also deactivated Mdm2 that effected overexpression of p53 which in turn upregulated p21 expression. This causes enhanced p21 binding to cyclin D1 that halted G1 to S phase progression. Taken together, VCO produces two prong effects on lung cancer cells, it induces apoptosis and blocked cancer cell proliferation, both occurred due to the deactivation of Akt. In addition, it has another crucial advantage: VCO could be directly delivered to lung cancer tissue through inhalation.

  7. A Wiki-based Key to Garden and Village Birds

    OpenAIRE

    Trilar, Tomi

    2010-01-01

    A Wiki-based Key to Garden and Village Birds is available in two versions: a dichotomous, hyperlinked and printable version, and as step-bystep identification version. It is supported by jKey Player in English, Slovenian, Spanish, Romanian and German.

  8. Brain damage in former association football players

    International Nuclear Information System (INIS)

    Thirty-three former football players from the National Football Team of Norway were examined by cerebral computer tomography (CT). The CT studies, evaluated for brain atrophy, visually and by linear measurements compared two different normal materials. One third of the players were found to have central cerebral atrophy. It is concluded that the atrophy probably was caused by repeated small head injuries during the football play, mainly in connection with heading the ball. (orig.)

  9. Mental Rotation Performance in Male Soccer Players

    OpenAIRE

    Jansen, Petra; Lehmann, Jennifer; Van Doren, Jessica

    2012-01-01

    It is the main goal of this study to investigate the visual-spatial cognition in male soccer players. Forty males (20 soccer players and 20 non-athletes) solved a chronometric mental rotation task with both cubed and embodied figures (human figures, body postures). The results confirm previous results that all participants had a lower mental rotation speed for cube figures compared to embodied figures and a higher error rate for cube figures, but only at angular disparities greater than 90°. ...

  10. Game Performance Evaluation in Male Goalball Players.

    Science.gov (United States)

    Molik, Bartosz; Morgulec-Adamowicz, Natalia; Kosmol, Andrzej; Perkowski, Krzysztof; Bednarczuk, Grzegorz; Skowroński, Waldemar; Gomez, Miguel Angel; Koc, Krzysztof; Rutkowska, Izabela; Szyman, Robert J

    2015-11-22

    Goalball is a Paralympic sport exclusively for athletes who are visually impaired and blind. The aims of this study were twofold: to describe game performance of elite male goalball players based upon the degree of visual impairment, and to determine if game performance was related to anthropometric characteristics of elite male goalball players. The study sample consisted of 44 male goalball athletes. A total of 38 games were recorded during the Summer Paralympic Games in London 2012. Observations were reported using the Game Efficiency Sheet for Goalball. Additional anthropometric measurements included body mass (kg), body height (cm), the arm span (cm) and length of the body in the defensive position (cm). The results differentiating both groups showed that the players with total blindness obtained higher means than the players with visual impairment for game indicators such as the sum of defense (p = 0.03) and the sum of good defense (p = 0.04). The players with visual impairment obtained higher results than those with total blindness for attack efficiency (p = 0.04), the sum of penalty defenses (p = 0.01), and fouls (p = 0.01). The study showed that athletes with blindness demonstrated higher game performance in defence. However, athletes with visual impairment presented higher efficiency in offensive actions. The analyses confirmed that body mass, body height, the arm span and length of the body in the defensive position did not differentiate players' performance at the elite level. PMID:26834872

  11. RETIRED MATCHES AMONG MALE PROFESSIONAL TENNIS PLAYERS

    Directory of Open Access Journals (Sweden)

    Kristijan Breznik

    2012-06-01

    Full Text Available The aim of this study was to explore the effect of characteristics of various games and players on the proportion of retired tennis matches in the Open Era of tennis. The data included over 420,000 matches played among 17,553 tennis players in the period from 1968 to the end of 2010. The influence of the surface type was clearly confirmed, with the proportion of retired matches being higher on hard and clay courts compared to grass and carpet surfaces. Similarly, more retired matches were observed in outdoor venues than in indoor ones. The impact of other variables, tournament types, rounds at which the game was played and both players' ranks, is more ambiguous. Our interpretation of the obtained results is presented in the paper. Network analytic methods were applied to extract players with the most retired matches in their careers. Eventually, we defined a group of top tennis players and gave a more precise insight into retired matches in that group. Correspondence analysis was used to visually display the two-mode network of top players and the proportion of retired matches by surface type

  12. Regulation of apoptosis by peroxisome proliferators.

    Science.gov (United States)

    Roberts, Ruth A; Michel, Cecile; Coyle, Beth; Freathy, Caroline; Cain, Kelvin; Boitier, Eric

    2004-04-01

    . Results show that some of the key steps of the LCM process had an impact on the gene profiles generated. However, this did not preclude accurate determination of a PP-specific molecular signature. Thus, the choice of appropriate controls will ensure that meaningful gene expression analyses can be performed on tissue microdissected from the foci generated in clofibric acid treated livers. These data will allow the identification of specific genes that are regulated by PPs leading to changes in apoptosis and ultimately to tumours. PMID:15093246

  13. “A COMPARATIVE STUDY AMONG INDOOR GAME PLAYERS AND OUTDOOR GAME PLAYERS RESPECT TO GROUP CONFORMITY AND SOCIAL LOAFING”

    OpenAIRE

    Quadri Syed Javeed

    2015-01-01

    Aim of the study was to investigate the group conformity and social loafing among Indoor Game Players’ Outdoor Game Players. Hypotheses: first there was no significant difference between Indoor Game Players and Outdoor Game Players with respect to group conformity. Second was there was no significant difference between Indoor Game Players and Outdoor Game Players with respect to social loafing. Sample: For the present study 90 Sample were belongings to and Aurangabad, 45 subjects wer...

  14. Inhibitor of apoptosis proteins and apoptosis

    Institute of Scientific and Technical Information of China (English)

    Yunbo Wei; Tingjun Fan; Miaomiao Yu

    2008-01-01

    Apoptosis is a physiological cell death process that plays a critical role in development, homeostasis, and immune defense of multicellular animals. Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that possess between one and three baculovirus IAP repeats. Some of them also have a really interesting new gene finger domain, and can prevent cell death by binding and inhibiting active caspases, but are regulated by IAP antagonists. Some evidence also indicates that IAP can modulate the cell cycle and signal transduction. The three main factors, IAPs, IAP antagonists, and caspases, are involved in regulating the progress of apoptosis in many species. Many studies and assumptions have been focused on the anfractuous interactions between these three main factors to explore their real functional model in order to develop potential anticancer drugs.In this review, we describe the classification, molecular structures, and properties of IAPs and discuss the mechanisms of apoptosis. We also discuss the promising significance of clinical applications of IAPs in the diagnosis and treatment of malignancy.

  15. Anthropometric profile and body composition of Irish adolescent rugby union players aged 16-18.

    Science.gov (United States)

    Delahunt, Eamonn; Byrne, Risteard B; Doolin, Rachel K; McInerney, Rory G; Ruddock, Ciaran T J; Green, Brian S

    2013-12-01

    The literature suggests that one of the key determinants of success at rugby union international competitions is the anthropometric profile of players. The Irish Rugby Football Union (IRFU) long-term player development (LTPD) model is a framework designed to guide the development of the tactical, physical, and psychological domains of sporting participation. In Ireland, the Train-to-Train stage of the IRFU model is a critical stage, whereby the next developmental progression would include the transition of players into professional academies. To date, no previously published studies have examined the anthropometric profile of Irish Schools' rugby union players at the Train-to-Train stage of the IRFU model. The anthropometric profile of 136 male adolescent rugby union players at the Train-to-Train stage of the IRFU model was assessed using total-body dual-energy x-ray absorptiometry. Significant differences in height, body mass, body fat percentage, fat mass, lean mass, and fat-free mass were observed between players assigned to the forward and back units, and for specific position categorizations within each unit. Direct logistic regression revealed that body mass was a statistically significant (p < 0.01) predictor of unit position classification, with an odds ratio of 2.35, indicating that the players with a higher body mass were twice as likely to be classified as forwards. The results of this study indicate that at the Train-to-Train stage of the IRFU model, forward and back units have distinctly different anthropometric profiles. Furthermore, anthropometric differentiation also exists within specific position categorizations within each of these playing units. Thus, anthropometric profiling should be carried out on a systematic and periodic basis, because this will allow for the evaluation of the effectiveness of the implementation strategies of the IRFU model on a national basis. PMID:23539077

  16. Caspases: An apoptosis mediator

    Directory of Open Access Journals (Sweden)

    Tapan Kumar Palai

    2015-03-01

    Full Text Available The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy - dependent biochemical mechanisms. Apoptosis is a widely conserved phenomenon helping many processes, including normal cell turnover, proper development and functioning of the immune system, hormone dependent atrophy etc. Inappropriate apoptosis (either low level or high level leads to many developmental abnormalities like, neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. To use cells for therapeutic purposes through generating cell lines, it is critical to study the cell cycle machinery and signalling pathways that controls cell death and apoptosis. Apoptotic pathways provide a fundamental protective mechanism that decreases cellular sensitivity to damaging events and allow proper developmental process in multi-cellular organisms. Major mediator of apoptosis is a family of proteins known as caspases. There are mainly fourteen types of caspases but out of them only ten caspasese have got essential role in controlling the process of apoptosis. These ten caspases have been categorized into either initiator caspases (caspase 2, 8, 9, 10 or executioner caspases (caspase 3, 6, 7. Although various types of caspases have been identified so far, the exact mechanisms of action of these groups of proteins is still to be fully understood. The aim of this review is to provide a detail overview of role of different caspases in regulating the process of apoptosis.

  17. Trace elements and apoptosis

    Energy Technology Data Exchange (ETDEWEB)

    Koudrine, A.V. [Orenburg State Medical Academy, Orenburg (Russian Federation)

    1998-07-01

    It is known that apoptosis is considered to be responsible for selective deletion of cells during embryogenesis, the homeostasis of cell populations in continuously renewing tissues (i.e., serving as a counterbalance to mitosis), and tissue involution in response to chemical or physical stimuli. There are many publications on these questions. On the other hand, the intracellular processes that contribute to apoptosis are incompletely understood. Therefore, the role of apoptosis in the intracellular accumulation and outflow of minerals is of considerable importance in light of both their essential functions and toxic effects. (orig.)

  18. DNA fragmentation in apoptosis

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Cleavage of chromosomal DNA into oligonucleosomal size fragments is an integral part of apoptosis. Elegant biochemical work identified the DNA fragmentation factor (DFF) as a major apoptotic endonuclease for DNA fragmentation in vitro. Genetic studies in mice support the importance of DFF in DNA fragmentation and possibly in apoptosis in vivo. Recent work also suggests the existence of additional endonucleases for DNA degradation. Understanding the roles of individual endonucleases in apoptosis, and how they might coordinate to degrade DNA in different tissues during normal development and homeostasis, as well as in various diseased states, will be a major research focus in the near future.

  19. Apoptosis in Drosophila: which role for mitochondria?

    Science.gov (United States)

    Clavier, Amandine; Rincheval-Arnold, Aurore; Colin, Jessie; Mignotte, Bernard; Guénal, Isabelle

    2016-03-01

    It is now well established that the mitochondrion is a central regulator of mammalian cell apoptosis. However, the importance of this organelle in non-mammalian apoptosis has long been regarded as minor, mainly because of the absence of a crucial role for cytochrome c in caspase activation. Recent results indicate that the control of caspase activation and cell death in Drosophila occurs at the mitochondrial level. Numerous proteins, including RHG proteins and proteins of the Bcl-2 family that are key regulators of Drosophila apoptosis, constitutively or transiently localize in mitochondria. These proteins participate in the cell death process at different levels such as degradation of Diap1, a Drosophila IAP, production of mitochondrial reactive oxygen species or stimulation of the mitochondrial fission machinery. Here, we review these mitochondrial events that might have their counterpart in human. PMID:26679112

  20. The polygenic profile of Russian football players.

    Science.gov (United States)

    Egorova, Emiliya S; Borisova, Alyona V; Mustafina, Leysan J; Arkhipova, Alina A; Gabbasov, Rashid T; Druzhevskaya, Anastasiya M; Astratenkova, Irina V; Ahmetov, Ildus I

    2014-01-01

    Research concerned with predictors of talent in football has highlighted a number of potentially important and partially inherited measures such as body size, anaerobic power, aerobic capacity, agility, psychological profile, game intelligence and susceptibility to injuries. Genotyping for performance-associated DNA polymorphisms at an early age could be useful in predicting later success in football. The aim of the study was to investigate individually and in combination the association of common gene polymorphisms with football player's status. A total of 246 Russian football players and 872 controls were genotyped for 8 gene polymorphisms, which were previously reported to be associated with athlete status. Four alleles (ACE D, ACTN3 Arg577, PPARA rs4253778 C and UCP2 55Val) were first identified, showing discrete associations with football player's status. Next, we determined the total genotype score (TGS, from the accumulated combination of the 4 polymorphisms, with a maximum value of 100 for the theoretically optimal polygenic score) in athletes and controls. The mean TGS was significantly higher in football players (52.0 (17.6) vs. 41.3 (15.5); P < 0.0001) than in controls. These data suggest that the likelihood of becoming a football player depends on the carriage of a high number of "favourable" gene variants. PMID:24784145

  1. Game Performance Evaluation in Male Goalball Players

    Directory of Open Access Journals (Sweden)

    Molik Bartosz

    2015-12-01

    Full Text Available Goalball is a Paralympic sport exclusively for athletes who are visually impaired and blind. The aims of this study were twofold: to describe game performance of elite male goalball players based upon the degree of visual impairment, and to determine if game performance was related to anthropometric characteristics of elite male goalball players. The study sample consisted of 44 male goalball athletes. A total of 38 games were recorded during the Summer Paralympic Games in London 2012. Observations were reported using the Game Efficiency Sheet for Goalball. Additional anthropometric measurements included body mass (kg, body height (cm, the arm span (cm and length of the body in the defensive position (cm. The results differentiating both groups showed that the players with total blindness obtained higher means than the players with visual impairment for game indicators such as the sum of defense (p = 0.03 and the sum of good defense (p = 0.04. The players with visual impairment obtained higher results than those with total blindness for attack efficiency (p = 0.04, the sum of penalty defenses (p = 0.01, and fouls (p = 0.01. The study showed that athletes with blindness demonstrated higher game performance in defence. However, athletes with visual impairment presented higher efficiency in offensive actions. The analyses confirmed that body mass, body height, the arm span and length of the body in the defensive position did not differentiate players’ performance at the elite level.

  2. Apoptosis in Pneumovirus Infection

    Directory of Open Access Journals (Sweden)

    Reinout A. Bem

    2013-01-01

    Full Text Available Pneumovirus infections cause a wide spectrum of respiratory disease in humans and animals. The airway epithelium is the major site of pneumovirus replication. Apoptosis or regulated cell death, may contribute to the host anti-viral response by limiting viral replication. However, apoptosis of lung epithelial cells may also exacerbate lung injury, depending on the extent, the timing and specific location in the lungs. Differential apoptotic responses of epithelial cells versus innate immune cells (e.g., neutrophils, macrophages during pneumovirus infection can further contribute to the complex and delicate balance between host defense and disease pathogenesis. The purpose of this manuscript is to give an overview of the role of apoptosis in pneumovirus infection. We will examine clinical and experimental data concerning the various pro-apoptotic stimuli and the roles of apoptotic epithelial and innate immune cells during pneumovirus disease. Finally, we will discuss potential therapeutic interventions targeting apoptosis in the lungs.

  3. A secure additive protocol for card players

    CERN Document Server

    Cordon-Franco, Andres; Fernandez-Duque, David; Joosten, Joost J; Soler-Toscano, Fernando

    2011-01-01

    Consider three players Alice, Bob and Cath who hold a, b and c cards, respectively, from a deck of d=a+b+c cards. The cards are all different and players only know their own cards. Suppose Alice and Bob wish to communicate their cards to each other without Cath learning whether Alice or Bob holds a specific card. Considering the cards as consecutive natural numbers 0,1,..., we investigate general conditions for when Alice or Bob can safely announce the sum of the cards they hold modulo an appropriately chosen integer. We demonstrate that this holds whenever a,b>2 and c=1. Because Cath holds a single card, this also implies that Alice and Bob will learn the card deal from the other player's announcement.

  4. There is no game without a player

    DEFF Research Database (Denmark)

    Larsen, Lasse Juel

    on the subject matter from the catalogue of game theory. All four suggestions exclude the player from the relationship. This paper introduces a phenomenological point of view and includes the player in order to understand the relationship between structure and dressing. It argues that players constitute a bridge......This paper is a search for meaning or to be more precise a study of how meaning is produced between ontology and fiction in computer games. It sets out to investigate the relationship between formal abstract game structures and game representation (dressing) by presenting four suggestions...... or the center which establishes, upholds and renegotiate the relationship between formal game structure and game dressing. It also argues that players’ interaction with both structure and dressing produce meaning and the production of meaning is the relationship between formal abstract game structures and game...

  5. Motivation and Sport Injuries in Handball Players

    Directory of Open Access Journals (Sweden)

    Laguna, María

    2010-12-01

    Full Text Available The aim of the study was to test whether different levels of motivation are related to the injuries suffered by elite athletes. The sample consists of 80 professional handball players of ASOBAL League, with a mean age of 24.83 years (+ 5.21. Motivation was assessed through the CPRD scale (Gimeno, Buceta & Pérez-Llantada; 1999 and a self-report questionnaire was used to register sports injuries. The results indicate that there is a relationship between motivational levels and the risk for injury. Specifically, players with high motivated players had a greater number of moderate injuries. Although it may seem paradoxical, it is possible that an excessively high motivation leads to overachievement and risk behaviors, which in turn facilitate the appearance of lesions.

  6. Dental apoptosis: caspases behind

    Czech Academy of Sciences Publication Activity Database

    Matalová, Eva; Fleischmannová, Jana; Míšek, Ivan; Sharpe, P. T.; Tucker, A. S.

    Ljubljana: ECDO, 2007, s. 26-26. [Euroconference on Apoptosis /15./ and Training Course on Concepts and Methods in Programmed Cell Death /4./. Portorož (SI), 26.10.2007-31.10.2007] R&D Projects: GA MŠk OC B23.001; GA AV ČR KJB500450503 Institutional research plan: CEZ:AV0Z50450515 Keywords : dental apoptosis Subject RIV: FF - HEENT, Dentistry

  7. ACTN3 genotype in professional soccer players

    OpenAIRE

    Santiago Dorrego, Catalina; González-Freire, Marta; Serratosa Fernández, Luis; Morate, F. J.; Meyer, T.; Gómez Gallego, Félix; Lucía Mulas, Alejandro

    2008-01-01

    The authors studied the frequency distribution of alpha-actinin-3 (ACTN3) R577X genotypes in 60 top-level professional soccer players. The results were compared with those of 52 elite endurance athletes and 123 sedentary controls. The per cent distribution of RR and RX genotypes in soccer players (48.3% and 36.7%) was significantly higher and lower, respectively, than controls (28.5% and 53.7%) and endurance athletes (26.5% and 52%) (p = 0.041). Although there are notable exceptions, elite so...

  8. Designing Goals for Online Role-Players

    OpenAIRE

    Montola, Markus

    2005-01-01

    The increasing popularity of massively multi-player online role-playing and the rise of the role-playing-related pervasive gaming create a new challenge for the digital gaming industry. The role-player audience is growing in addition to the digital gamer audience. Catering to the both crowds requires re-thinking in the game design. In this paper I propose that one of the most fundamental differences is the difference in goal structures and the idea of "meaningful" play between the two gaming ...

  9. Chess players' fame versus their merit

    OpenAIRE

    Simkin, M. V.; Roychowdhury, V. P.

    2015-01-01

    We investigate a pool of international chess title holders born between 1901 and 1943. Using Elo ratings, we compute for every player his expected score in a game with a randomly selected player from the pool. We use this figure as the player’s merit. We measure players’ fame as the number of Google hits. The correlation between fame and merit is 0.38. At the same time, the correlation between the logarithm of fame and merit is 0.61. This suggests that fame grows exponentially with merit.

  10. Power-strength curve in basketball players

    OpenAIRE

    Salvador Romero; Helena Vila; Carmen Ferragut; Alcaraz, Pedro E

    2009-01-01

    The purpose of this study was to examine the power-strength curve in a half squat exercise in trained basketball players of the EBA league. For that, a cross sectional, descriptive study was carried out to 8 high-level male basketball players. After controlling the participants 1RM, a progressive test, consisted on moving loads of 30, 45, 60, 70 and 80% of 1RM as fast as possible in the concentric phase, was performed. The participants showed the highest peak power output with loads of 45%...

  11. EVALUATION OF PAINFUL SHOULDER IN BASEBALL PLAYERS

    OpenAIRE

    Miyazaki, Alberto Naoki; Fregoneze, Marcelo; Santos, Pedro Doneux; da Silva, Luciana Andrade; do Val Sella, Guilherme; Junior, Adriano Fernando Mendes; Soares, André Lopes; Aihara, Leandro Jun; Checchia, Sérgio Luiz

    2015-01-01

    Objective: To assess the relationship between shoulder mobility and strength and the presence of pain among baseball players. Methods: Between April and July 2009, 55 baseball players were assessed by the Shoulder and Elbow Group of the School of Medical Sciences, Santa Casa de Misericórdia, São Paulo. They were all males, aged between 15 and 33 years (mean of 21); they attended an average of three training sessions per week and had been doing this sport for a mean of 10 years. Results: 14 of...

  12. RETIRED MATCHES AMONG MALE PROFESSIONAL TENNIS PLAYERS

    OpenAIRE

    Kristijan Breznik; Vladimir Batagelj

    2012-01-01

    The aim of this study was to explore the effect of characteristics of various games and players on the proportion of retired tennis matches in the Open Era of tennis. The data included over 420,000 matches played among 17,553 tennis players in the period from 1968 to the end of 2010. The influence of the surface type was clearly confirmed, with the proportion of retired matches being higher on hard and clay courts compared to grass and carpet surfaces. Similarly, more retired matches were obs...

  13. May a weak tennis player win?

    OpenAIRE

    SIVAK, OLEKSANDR

    2016-01-01

    The winner of a competition depends on the choice of actual matches played. We assume that each match is played between two players. Our goal is to examine which players can be made winners of a competition if we know any match result in advance. We only consider competitions in which the winner of a single match progresses to the next round and the loser leaves the competition. We focus on tennis competitions and use real data downloaded from atpworldtour.com. The final winner of a competiti...

  14. Short Duration Heat Acclimation in Australian Football Players.

    Science.gov (United States)

    Kelly, Monica; Gastin, Paul B; Dwyer, Daniel B; Sostaric, Simon; Snow, Rodney J

    2016-03-01

    This study examined if five sessions of short duration (27 min), high intensity, interval training (HIIT) in the heat over a nine day period would induce heat acclimation in Australian football (AF) players. Fourteen professional AF players were matched for VO2peak (mL·kg(-1)·min(-1)) and randomly allocated into either a heat acclimation (Acc) (n = 7) or Control (Con) group (n = 7). The Acc completed five cycle ergometer HIIT sessions within a nine day period on a cycle ergometer in the heat (38.7 ± 0.5 °C; 34.4 ± 1.3 % RH), whereas Con trained in thermo-neutral conditions (22.3 ± 0.2 °C; 35.8 ± 0. % RH). Four days prior and two days post HIIT participants undertook a 30 min constant load cycling test at 60% V̇O2peak in the heat (37.9 ± 0.1 °C; 28.5 ± 0.7 % RH) during which VO2, blood lactate concentration ([Lac(-)]), heart rate (HR), rating of perceived exertion (RPE), thermal comfort, core and skin temperatures were measured. Heat acclimation resulted in reduced RPE, thermal comfort and [Lac(-)] (all p HIIT, in both groups. Heat acclimation did not influence any other measured variables. In conclusion, five short duration HIIT sessions in hot dry conditions induced limited heat acclimation responses in AF players during the in-season competition phase. In practice, the heat acclimation protocol can be implemented in a professional team environment; however the physiological adaptations resulting from such a protocol were limited. Key pointsSome minor heat acclimation adaptations can be induced in professional AF players with five 27 min non-consecutive, short duration HIIT sessions in the heat.The heat acclimation protocol employed in this study was able to be implemented in a professional team sport environment during an actual competitive season.Elevating and maintaining a high core temperature sufficient for heat acclimation likely requires a longer heat training session or some pre-heating prior to exercise. PMID:26957934

  15. Role of heat shock proteins in cell apoptosis

    Directory of Open Access Journals (Sweden)

    Arleta Kaźmierczuk

    2010-06-01

    Full Text Available Apoptosis is, apart from necrosis and autophagy, one of the possible cell death mechanisms eliminating needless, not normal or infected cells. This process ensures quantitative and qualitative cell control of organisms. Apoptosis is tightly regulated, it requires both activation of a large number of genes and energy input. Up-to-date two main apoptotic pathways have been recognized – external/receptor and internal, processed with the participation of mitochondria. Heat shock proteins HSPs, the molecules known from their chaperone activity and molecular conservatism, play essential functions in the course of apoptosis. Among that proteins family, i.e. HSP100, 90, 70, 60, 40 and small molecular (sHSP, there are agents mainly protective against programmed cell death. However, in some conditions some of these proteins may promote apoptosis. This review describes different key apoptotic proteins interacting with main members of HSP family and the consequence of these events for cell survival or apoptosis.

  16. Five models of players' rule behavior for game balance.

    Science.gov (United States)

    Song, Seungkeun; Kim, Mijin

    2012-09-01

    We present a five-part model of players' rule behaviors in a multiplayer online game (utilization, emergence, usefulness, usefulness-balance, and balance-usefulness). The model was identified through a pilot study involving nine expert players. The model fitness was then verified in a main experiment involving eighteen regular players. Our results showed that the utilization (4 players) and emergence (4 players) models were most frequently used, followed by the balance-usefulness (3 players), usefulness (3 players), and usefulness-balance (2 players) models. The coding scheme for this research was built from video observations and a literature review. We suggest this model is applicable for the implementation of a human-like virtual character's artificial intelligence algorithm in the game editors and the server loader for quality assurance. PMID:22817612

  17. High School Football Players Suffer More Symptoms After Concussion

    Science.gov (United States)

    ... gov/medlineplus/news/fullstory_158603.html High School Football Players Suffer More Symptoms After Concussion: Study Meanwhile, ... MONDAY, May 2, 2016 (HealthDay News) -- High school football players are more likely to suffer more symptoms ...

  18. Advanced Tennis for Coaches, Teachers and Players.

    Science.gov (United States)

    Tilmanis, Gundars A.

    This book is designed to help the reader attain a real understanding of the mechanics of tennis. It provides an important link between tennis theory and practice. The book covers activities that develop skills in beginners through advanced tennis and tactics applicable for seasoned players. The author draws upon scientific principles of…

  19. Low Back Pain in a Tennis Player.

    Science.gov (United States)

    Bracker, Mark; And Others

    1988-01-01

    A group of physicians meet to discuss a case in which a middle-aged tennis player suffers from low back pain. The diagnosis, treatment and management of the case are discussed. The article is one in an occasional series. (JL)

  20. Assessment of Cardiovascular Risk in Collegiate Football Players and Nonathletes

    Science.gov (United States)

    Dobrosielski, Devon A.; Rosenbaum, Daryl; Wooster, Benjamin M.; Merrill, Michael; Swanson, John; Moore, J. Brian; Brubaker, Peter H.

    2010-01-01

    Collegiate American football players may be at risk for cardiovascular disease. Objective: To compare cardiovascular disease risk factors and cardiovascular structure and function parameters of football players, stratified by position, to a group of sedentary, nonathletes. Participants: Twenty-six collegiate football players and 13 nonathletes…

  1. Synthetic Players: A Quest for Artificial Intelligence in Computer Games

    Directory of Open Access Journals (Sweden)

    Jouni Smed

    2005-03-01

    Full Text Available Synthetic players are the computer-controlled actors in a computer game. In this paper, we describe both the implementation issues and the behavioural expectations related to synthetic players. We recognize the role of synthetic players by analysing the components of games in general and computer games in particular.

  2. Preferred Leadership Behaviours of Male and Female Badminton Players

    OpenAIRE

    Rajkumar S HARMA

    2015-01-01

    Pr eferences for specific coaching behaviours of male and female Badminton players were measured by the modified and revised Leadership Scale for Sport. Eighty two (Males=61, Females=21) badminton players were selected from amongst the players representing th eir respective university teams in East - zone Inter - university Badminton (Men/Women) tournaments held at Bilaspur (CG). The present investigation noted ...

  3. Poliovirus, pathogenesis of poliomyelitis, and apoptosis.

    OpenAIRE

    Blondel, B.; Colbère-Garapin, F.; Couderc, T.; Wirotius, A.; Guivel-Benhassine, F.

    2005-01-01

    Poliovirus (PV) is the causal agent of paralytic poliomyelitis, an acute disease of the central nervous system (CNS) resulting in flaccid paralysis. The development of new animal and cell models has allowed the key steps of the pathogenesis of poliomyelitis to be investigated at the molecular level. In particular, it has been shown that PV-induced apoptosis is an important component of the tissue injury in the CNS of infected mice, which leads to paralysis. In this review the molecular biolog...

  4. National Football League Player Market: Are Professional Players Still Paid Monopsony Wages?

    OpenAIRE

    Miškovský, Karel

    2012-01-01

    The main goal of this thesis is to find out whether National football league players are, even 15 years after the birth of unrestricted free agency, still paid monopsonistic salaries or whether competition among NFL teams eliminated them. After a theoretical discussion, which will help to form expectations about the player market, models in line with the standard theory of labor compensation and with Becker's human capital theory are estimated. The part of the research following the standard ...

  5. Football players, asset management & the unexploited potential of enhanced player engagement in football management & marketing

    DEFF Research Database (Denmark)

    Cortsen, Kenneth

    2014-01-01

    This article gives insights into why and how football brands (e.g. clubs and governing bodies) can benefit from enhancing the activation of players in football management and football marketing initiatives.......This article gives insights into why and how football brands (e.g. clubs and governing bodies) can benefit from enhancing the activation of players in football management and football marketing initiatives....

  6. Electromyographic assessment of forearm muscle function in tennis players with and without Lateral Epicondylitis.

    Science.gov (United States)

    Alizadehkhaiyat, Omid; Frostick, Simon P

    2015-12-01

    There is no consensus about the main aetiology of Lateral Epicondylitis (LE) or Tennis Elbow. While electromyographic assessment of alterations in neuromuscular control and activation patterns of forearm muscles has received increasing interest as potential intrinsic factors in non-tennis players, there has been insufficient attention in tennis players. The purpose of present review was to search the literature for the electromyographic studies of forearm muscles in tennis players in order to (1) identify related implications for LE, (2) highlight key technical and methodological shortcomings, and (3) suggest potential pathways for future research. An electronic search of PubMed, Scopus, Web of Science, and Google Scholars (1980 to October 2014) was conducted. Titles, abstracts, and full-text articles were screened to identify "peer-reviewed" studies specifically looking into "electromyographic assessment of forearm muscles" in "tennis players". After screening 104 articles, 13 original articles were considered in the main review involving a total of 216 participants (78% male, 22% female). There were indications of increased wrist extensor activity in all tennis strokes and less experienced single-handed players, however with insufficient evidence to support their relationship with the development of LE. Studies varied widely in study population, sample size, gender, level of tennis skills, electrode type, forearm muscles studied, EMG recording protocol, EMG normalisation method, and reported parameters. As a result, it was not possible to present combined results of existing studies and draw concrete conclusions in terms of clinical implications of findings. There is a need for establishment of specific guidelines and recommendations for EMG assessment of forearm musculature particularly in terms of electrode and muscle selection. Further studies of both healthy controls and tennis players suffering from LE with adequate sample sizes and well-defined demographics

  7. The European gas market players. 2001 edition

    International Nuclear Information System (INIS)

    The European gas industry has embarked on a new era, driven by new Community regulations as well as the growth of gas demand due to the undeniable and economic and environmental advantages offered by this energy source, as well as the dynamism of the main players. The year 2000 will remain marked by the vigour and steady growth of the European gas market: production (278.5 Bcm), trade (248.1 Bcm) and consumption (414.3 Bcm), setting new records. And besides, the growth forecasts for gas demand in Europe, while masking differences between countries, remain highly optimistic for the coming decade. In this context of sweeping upheavals of the European gas market, combined with sharply growing demand, this report aims to describe the principal players of the market in 2000, as well as the developments registered by them since 1996, the date of the first report on The European Gas Market Players. A special effort has been made to place the European results of the different players in perspective with respect to their worldwide activities. Who produces natural gas in Europe*, who holds the reserves, who imports it, who exports, who sells it, how are the different European markets organized, who are the shareholders of the merchant gas companies, and what are the current holdings of these companies? These are the questions that this report addresses. A final chapter is dedicated to the principal transformations that have affected the European gas industry in recent years. By this synthetic and transverse view of the European gas market, the study details the evolution, role and positioning of the leading players. This document also proposes a precise view of the organization of the different domestic markets in 2000. (author)

  8. The European gas market players. 2001 edition

    Energy Technology Data Exchange (ETDEWEB)

    Mintz, J

    2001-07-01

    The European gas industry has embarked on a new era, driven by new Community regulations as well as the growth of gas demand due to the undeniable and economic and environmental advantages offered by this energy source, as well as the dynamism of the main players. The year 2000 will remain marked by the vigour and steady growth of the European gas market: production (278.5 Bcm), trade (248.1 Bcm) and consumption (414.3 Bcm), setting new records. And besides, the growth forecasts for gas demand in Europe, while masking differences between countries, remain highly optimistic for the coming decade. In this context of sweeping upheavals of the European gas market, combined with sharply growing demand, this report aims to describe the principal players of the market in 2000, as well as the developments registered by them since 1996, the date of the first report on The European Gas Market Players. A special effort has been made to place the European results of the different players in perspective with respect to their worldwide activities. Who produces natural gas in Europe*, who holds the reserves, who imports it, who exports, who sells it, how are the different European markets organized, who are the shareholders of the merchant gas companies, and what are the current holdings of these companies? These are the questions that this report addresses. A final chapter is dedicated to the principal transformations that have affected the European gas industry in recent years. By this synthetic and transverse view of the European gas market, the study details the evolution, role and positioning of the leading players. This document also proposes a precise view of the organization of the different domestic markets in 2000. (author)

  9. Dynamic Visual Acuity Training in Cricket Players

    Directory of Open Access Journals (Sweden)

    Renee Edgar, B.Optom

    2015-04-01

    Full Text Available Background: Dynamic visual acuity (DVA is the ability of an observer to correctly identify details of a moving target and is considered to be important for tasks like driving. Dynamic Visual Acuity is better in athletes involved in sports such as basketball and baseball; however, no previous studies have considered the sport of cricket. We conducted a study to determine whether there was any difference in DVA between cricket and non-cricket players. Method: Dynamic visual acuity was measured by asking subjects to identify the orientation of the gap of a moving Landolt C target as a four-alternative forced-choice task. The Landolt C targets had confusion bars surrounding them. The participants in the study were tested twice with a break of seven weeks. In between the two measurements, participants underwent two training sessions (similar to the testing sessions, each three weeks apart. Results: The initial mean DVA for cricket players was 107.7 deg/sec, and the mean DVA for non-cricket players was 105.5 deg/sec, with a target size of 6/15. The subjects who participated in training (cricketers and non-cricketers improved in DVA by 41 deg/sec in contrast to the improvement in the non-training subjects of 18 deg/sec (p=0.0032. The cricketers who participated in the training improved in DVA by 44 deg/sec, whereas the cricketers who did not participate in the training improved by 19 deg/sec (p=0.0167. Conclusions: We found no significant difference in initial DVA between the cricket players and the non-cricket players. The training resulted in an extremely significant improvement in DVA performance by both the cricketers and non-cricketers.

  10. Anthropometric Characteristics of Spanish Professional Basketball Players

    Directory of Open Access Journals (Sweden)

    Vaquera Alejandro

    2015-06-01

    Full Text Available The study of elite basketball players’ anthropometric characteristics alongside those of body composition contributes significantly to their profiling as professional athletes and plays an important role in the selection process, as these characteristics can have a significant impact on performance. In the current study, 110 professional basketball players from a series of Spanish professional Leagues (ACB, LEB and EBA and youth level National Teams (U20 and U18 had their anthropometric profiles measured and compared to determine differences between them. Furthermore, all 110 players were divided into three different categories according to their playing position: guards, forwards and centres. The results obtained show no significant differences between players in different competitions in weight, height and the sum of skinfolds. Nonetheless, there were several differences related to body fat content (13.03% in ACB players and 10.52% in the lower categories and National Teams. There were also several differences found between the different playing positions amongst all playing levels in body mass (79.56 ± 2.41, 91.04 ± 1.51 and 104.56 ± 1.73 kg, height (182.28 ± 0.96, 195.65 ± 1.00 and 204.08 ± 0.67 cm, skinfold distribution and perimeters. However, there were no significant differences in body fat content between the different playing positions. The conclusions obtained from this study provide a better understanding to basketball specialists regarding the selection process of players at the elite level, especially on the transition from youth elite programs to men’s elite leagues.

  11. Ion channels and beating heart: the players and the music

    Directory of Open Access Journals (Sweden)

    Charles Antzelevitch

    2011-12-01

    Full Text Available Soft gentle music accompanies us throughout our lifetime; it is the music of our heart beating. Although at times it is questionable as to who serves as conductor of the orchestra, there is little doubt that our ion channels are the main players. Whenever one of them plays too loudly, too softly or simply off key, disharmony results, sometimes leading to total disruption of the rate and rhythm. Ion channels can disrupt the music of our heart by different mechanisms. Sometimes their function is correct, but their expression is altered by underlying cardiac diseases (i.e. heart failure; sometimes the defect is in their structure, because of an underlying genetic defect, and in this case a channelopathy is present.

  12. A feedback control perspective on models of apoptosis signal transduction

    International Nuclear Information System (INIS)

    Apoptosis is a key regulator for replacing unused, old and damaged cells. Here we analyse three models of apoptosis. We deconstruct these models by linearising the models about the life steady state and applying methods from linear control theory. This control viewpoint uncovers a decentralised control scheme with a clear separation of plant and controller and reveals that the caspase inhibitors act as decentralised phase lead controllers

  13. Coping with stress and social support: A comparison between chess players and non-chess players

    Directory of Open Access Journals (Sweden)

    Jana Krivec

    2005-09-01

    Full Text Available Stress situations continue to represent an important factor of everyday life. The significance and role of stress are even greater in competitive sports. If not dealt with effectively, the pressure and demands of stress can reach proportions that seriously endanger the competitor. In the present study I examined the types of strategies chess players use in coping with stress situations during a single game aswell as through an entire tournament. In order to attain success, they need to overcome all stress factors. I further examined, to what extent and in what way chess players' coping strategies are effected by the support they have at hand in their social environment. Results obtained were compared with a group of non-chess players. The results have shown that chess players use a specific method of coping, which is, unexpectedly, directed more "away from the problem". The main reason for this may be that a loss of a chess game represents a situation, which is stressful and at the same time unalterable. Social support(emotional and practical attainable if need be, is perceived to a far greater extent by chess players than by non-chess players. The results attained from this study can be beneficial in the field of sport psychology, which frequently deals with similar performance patterns.

  14. Is There Chronic Brain Damage in Retired NFL Players? Neuroradiology, Neuropsychology, and Neurology Examinations of 45 Retired Players

    OpenAIRE

    Casson, Ira R.; Viano, David C.; Haacke, E. Mark; Kou, Zhifeng; LeStrange, Danielle G.

    2014-01-01

    Background: Neuropathology and surveys of retired National Football League (NFL) players suggest that chronic brain damage is a frequent result of a career in football. There is limited information on the neurological statuses of living retired players. This study aimed to fill the gap in knowledge by conducting in-depth neurological examinations of 30- to 60-year-old retired NFL players. Hypothesis: In-depth neurological examinations of 30- to 60-year-old retired players are unlikely to dete...

  15. Apoptosis: una muerte silenciosa

    OpenAIRE

    Isis Casadelvalle Pérez

    2006-01-01

    La apoptosis o muerte celular programada es un tipo de muerte presente en todas las células eucarióticas. Es un proceso ordenado y esencial del desarrollo normal y de mantenimiento de la homeostasis de un organismo. En el presente trabajo se resumen las principales características fisiológicas, bioquímicas y moleculares de la muerte por apoptosis, evento que ocurre de forma apagada o silenciosa, o sea, sin daño celular aparente diferenciándose claramente del proceso de necrosis celular. En es...

  16. [Sphingolipid and apoptosis].

    Science.gov (United States)

    Wang, Jing; Hu, Xiao-Song; Shi, Jie-Ping

    2003-07-01

    Over the last decade, considerable progress has been made in the study of sphingolipids with the development of biological techniques. Sphingolipids play important roles in diverse physiological process, including cytoskeleton migration, angiogenesis, embryonic development and signal transduction. Except for this, the lastest evidence has suggested that sphingolipids and their metabolite (ceramide, sphingosine, sphingosine 1-phosphate) can induce apoptosis in a wide variety of tumor cell lines such as LoVo HT29, Bel7402, A549, CNE2 cells. This paper is attempted to review the recent advances of investigation into the relationship between sphingolipids and apoptosis. PMID:14628466

  17. Ankle sprain and postural sway in basketball players.

    Science.gov (United States)

    Leanderson, J; Wykman, A; Eriksson, E

    1993-01-01

    The present study compares postural ankle stability between previously injured basketball players, uninjured players and a control/group. Postural sway was recorded and analysed by stabilometry using a specially designed computer-assisted forceplate. Recordings were obtained for 60 s on each foot. The stabilometric results in the players with no previous injuries did not differ from those in the controls. Players with a previously injured ankle differed significantly from the control group. These players had a larger mean postural sway and used a larger sway area. PMID:8536030

  18. Multi-Player and Multi-Choice Quantum Game

    Institute of Scientific and Technical Information of China (English)

    杜江峰; 李卉; 许晓栋; 周先意; 韩荣典

    2002-01-01

    We investigate a multi-player and multi-choice quantum game. We start from a two-player and two-choice game,and the result is better than its classical version. Then we extend this to N-player and N-choice cases. In the quantum domain, we provide a strategy with which players can always avoid the worst outcome. Also, by changing the value of the parameter of the initial state, the probabilities for players to obtain the best pay-off will be much higher than in its classical version.

  19. Does competitive entry structurally change key marketing metrics?

    NARCIS (Netherlands)

    Kornelis, Marcel; Dekimpe, Marnik G.; Leeflang, Peter S. H.

    2008-01-01

    To what extent does competitive entry create a structural change in key marketing metrics? New players mayjust be a temporal nuisance to incumbents, but could also fundamentally change the latter's performance evolution, or induce them to permanently alter their spending levels and/or pricing decisi

  20. H:Q Ratios and Bilateral Leg Strength in College Field and Court Sports Players

    OpenAIRE

    Cheung, Roy T.H.; Smith, Andrew W.; Wong, Del P.

    2012-01-01

    One of the key components in sports injury prevention is the identification of imbalances in leg muscle strength. However, different leg muscle characteristics may occur in large playing area (field) sports and small playing area (court) sports, which should be considered in regular injury prevention assessment. This study examined the isokinetic hamstrings-to-quadriceps (H:Q) ratio and bilateral leg strength balance in 40 male college (age: 23.4 ± 2.5 yrs) team sport players (field sport = 2...

  1. Calpain Activator Dibucaine Induces Platelet Apoptosis

    Directory of Open Access Journals (Sweden)

    Jun Liu

    2011-03-01

    Full Text Available Calcium-dependent calpains are a family of cysteine proteases that have been demonstrated to play key roles in both platelet glycoprotein Ibα shedding and platelet activation and altered calpain activity is associated with thrombotic thrombocytopenic purpura. Calpain activators induce apoptosis in several types of nucleated cells. However, it is not clear whether calpain activators induce platelet apoptosis. Here we show that the calpain activator dibucaine induced several platelet apoptotic events including depolarization of the mitochondrial inner transmembrane potential, up-regulation of Bax and Bak, down-regulation of Bcl-2 and Bcl-XL, caspase-3 activation and phosphatidylserine exposure. Platelet apoptosis elicited by dibucaine was not affected by the broad spectrum metalloproteinase inhibitor GM6001. Furthermore, dibucaine did not induce platelet activation as detected by P-selectin expression and PAC-1 binding. However, platelet aggregation induced by ristocetin or α-thrombin, platelet adhesion and spreading on von Willebrand factor were significantly inhibited in platelets treated with dibucaine. Taken together, these data indicate that dibucaine induces platelet apoptosis and platelet dysfunction.

  2. Effect of 2-wk intensified training and inactivity on muscle Na+/K+ pump expression, phospholemman (FXYD1) phosphorylation and performance in soccer players

    DEFF Research Database (Denmark)

    Thomassen, Martin; Christensen, Peter Møller; Gunnarsson, Thomas Gunnar Petursson; Nybo, Lars; Bangsbo, Jens

    2010-01-01

    The present study examined muscle adaptations and alterations in performance of highly trained soccer players with intensified training or training cessation. Eighteen elite soccer players were for a 2-wk period assigned to either a group which performed high intensity training with a reduction i......(+)/K(+) pump is changed by training and inactivity and may play a role for performance during repeated intense exercise. Key words: Fatigue, Training cessation, Performance, MCT1....

  3. The potential risk of personal stereo players

    DEFF Research Database (Denmark)

    Hammershøi, Dorte; Ordoñez, Rodrigo Pizarro; Reuter, Karen

    2010-01-01

    The technological development within personal stereo systems, such as MP3 players, e. g. iPods, has changed music listening habits from home entertainment to everyday and everywhere use. The technology has developed considerably, since the introduction of cassette players and CD walkmen. High......-level low-distortion music is produced by minimal devices which can play for long periods. In this paper, the existing literature on effects of personal stereo systems is reviewed, incl. studies of exposure levels, and effects on hearing. Generally, it is found that the levels being used are of concern......, which in one study is demonstrated to relate to the specific use in situations with high levels of background noise. Another study demonstrates that the effect of using personal stereo is comparable to that of being exposed to noise in industry. The results are discussed in view of the measurement...

  4. Macro-players in stock markets

    CERN Document Server

    Röhner, B M

    2005-01-01

    It is usually assumed that stock prices reflect a balance between large numbers of small individual sellers and buyers. However, over the past fifty years mutual funds and other institutional shareholders have assumed an ever increasing part of stock transactions: their assets, as a percentage of GDP, have been multiplied by more than one hundred. The paper presents evidence which shows that reactions to major shocks are often dominated by a small number of institutional players. Most often the market gets a wrong perception and inadequate understanding of such events because the relevant information (e.g. the fact that one mutual fund has sold several million shares) only becomes available weeks or months after the event, through reports to the Securities and Exchange Commission (SEC). Our observations suggest that there is a radical difference between small ($ 5% $) price changes which, on the contrary, may be caused by massive sales (or purchases) by a few players. This suggests that the mechanisms which a...

  5. Telemetry and Communication IP Video Player

    Science.gov (United States)

    OFarrell, Zachary L.

    2011-01-01

    Aegis Video Player is the name of the video over IP system for the Telemetry and Communications group of the Launch Services Program. Aegis' purpose is to display video streamed over a network connection to be viewed during launches. To accomplish this task, a VLC ActiveX plug-in was used in C# to provide the basic capabilities of video streaming. The program was then customized to be used during launches. The VLC plug-in can be configured programmatically to display a single stream, but for this project multiple streams needed to be accessed. To accomplish this, an easy to use, informative menu system was added to the program to enable users to quickly switch between videos. Other features were added to make the player more useful, such as watching multiple videos and watching a video in full screen.

  6. Player Transformation of Educational Multiplayer Games

    DEFF Research Database (Denmark)

    Magnussen, Rikke; Misfeldt, Morten

    2004-01-01

    are used for formal education. In this paper we argue that player transformation of educational games can, however, be the basis of exciting and unconventional learning of valuable things, such as how to transform information technology to better accommodate social interaction.......Children's great interest in multiplayer games has led to attempts to design educational multiplayer games. In this study, we have studied a test of an educational multiplayer game designed for mathematics education for children aged nine to twelve. In our observations, it became clear that pupils...... transformed the game to accommodate social interaction. With these transformed ways of playing the game, they managed to get to the top of the high score list while avoiding the educational parts of the game. Players transforming educational games to escape learning elements can be a problem when these games...

  7. DECISION-MAKING OF SPANISH FEMALE BASKETBALL TEAM PLAYERS WHILE THEY ARE COMPETING

    Directory of Open Access Journals (Sweden)

    Ana Concepci\\u00F3n Jim\\u00E9nez S\\u00E1nchez

    2009-01-01

    Full Text Available Decision-making play a very important role in basketball. While the game is taking place, players are constantly choosing what to do. In order to carry out this research work, two questions have been formulated: 1 how do high level female basketball players make a decision while they are competing? 2 which key components do they use to make the best decisions? The twelve players who make up the Spanish female basketball team have taken part in this project. They all participated in the 2008 FIBA World Olympic Qualifying Tournament, which took place in Madrid. This tournament allowed them to qualify and take part in the 2008 Olympic Games, where they finished in fifth place. A questionnaire and an interview have been used to make this research possible. The matches of the 2008 FIBA World Olympic Qualifying Tournament have also been analyzed. Those aspects in terms of the team's performance in 1x1 and 2x2 attack situations, and more specifically in pick actions, have been recorded and analyzed. In order to include these data, a system of specific categories and variables has been established. The results show that players are expert on making decisions during the competition. In order to come to this conclusion, their opinions, style of decision-making, as well as the way they move in 1x1 and 2x2 situations, were very useful. This research has also confirmed that decisions made by playmakers, forwards and centers are different.

  8. Personal and sports variables and injuries in handball players: A descriptive analysis

    Directory of Open Access Journals (Sweden)

    Aurelio Olmedilla Zafra

    2011-01-01

    Full Text Available AbstractThe aim of this work is to relate some of the personal variables (age and experience and sports (post game, sport category more important with injuries to players of handball. The study sample consisted of 100 handball players, with a mean age of 23.92 years (+ 5.21, of which 80% ASOBAL (Association Handball clubs in Spain competed in the league, and the other 20% did so between first and second division. For the evaluation of the variables using a self-report questionnaire in two parts: the first data is collected and sports personality variables, and the second will collect data on sports injuries. The results of this study indicate that the players suffer more injuries on average 2 in a season, with these minor fractures, muscle and tendinitis, being the player's quinces ASOBAL more is injured. The pivots and lateral suffer more injuries than the rest, and the porters seem to have a significantly lower tendency to injure anyone else. The older the greater the likelihood of injury. The completion of jobs that can determine the exact weight of each variable in the injury, which would be very important from prevention, and the performance of their own coaches.Key words: Sports injuries, handball, age, experience, post game, sport category

  9. Pure Java-based streaming MPEG player

    Science.gov (United States)

    Tolba, Osama; Briceno, Hector; McMillan, Leonard

    1999-01-01

    We present a pure Java-based streaming MPEG-1 video player. By implementing the player entirely in Java, we guarantee its functionality across platforms within any Java-enabled web browsers, without the need for native libraries. This allows greater sue of MPEG video sequences, because the users will no longer need to pre-install any software to display video, beyond Java compatibility. This player features a novel forward-mapping IDCT algorithm that allows it to play locally stored, CIF-sized video sequences at 11 frames per second, when run on a personal computer with Java 'just-in-time' compiler. The IDCT algorithm can run with greater speed when the sequence is viewed at reduced size; e.g., performing approximately 1/4 the amount of computation when the user resizes the sequence to 1/2 its original width and height. We are able to play video streams stored anywhere on the Internet with acceptable performance using a proxy server, eliminating the need for large-capacity auxiliary storage. Thus, the player is well suited to small devices, such as digital TV set-top decoders, requiring little more memory than is required for three video frames. Because of our modular design, it is possible to assemble multiple video streams from remote sources and present them simultaneously to the viewers, subject to network and local performance limitations. The same modular system can further provide viewers with their own customized view of each sessions; e.g., moving and resizing the video display window dynamically, and selecting their preferred set of video controls.

  10. Coordination of soccer players during preseason training.

    Science.gov (United States)

    Tessitore, Antonio; Perroni, Fabrizio; Cortis, Cristina; Meeusen, Romain; Lupo, Corrado; Capranica, Laura

    2011-11-01

    This study aimed to verify whether coordination improves as a result of a preseason soccer training. During 5 experimental sessions (days 1, 6, 11, 15, and 19), 16 semiprofessional male soccer players (22.0 ± 3.6 years) were administered 3 specific soccer tests (speed dribbling, shooting a dead ball, and shooting from a pass) and an interlimb coordination test (total duration of a trial: 60 seconds), consisting of isodirectional and nonisodirectional synchronized (1:1 ratio) hand and foot flexions and extensions at an increasing velocity of execution (80, 120, and 180 b·min(-1)). Furthermore, subjective ratings were monitored to assess the recovery state (RestQ) of the players, their perceived exertion (rating of perceived exertion [RPE]) for the whole body, and the perceived muscle pain (rating of muscle pain [RMP]) for the lower limbs and the internal training load by means of the session-RPE method. The ratios between post and pretraining RPE and RMP increased only during the first 2 experimental sessions and decreased after the second week of the training camp (p = 0.001). The Rest-Q showed increases (p < 0.05) for general stress, conflict/pressure, social recovery, and being in shape dimensions. Conversely, decreases (p < 0.05) were observed for social stress, fatigue, physical complaints dimensions. Throughout the preseason, the players improved their speed dribbling (p = 0.03), Shooting from a Pass (p = 0.02), and interlimb coordination (p < 0.0001) performances. These coordination tests succeeded in discriminating coordination in soccer players and could integrate field test batteries during the whole soccer season, because they were easily and inexpensively administrable by coaches. PMID:21993023

  11. Do economic players shape up fashion trends?

    OpenAIRE

    Hasan, Syed Akif; Subhani, Muhammad Imtiaz; Osman, Ms. Amber

    2012-01-01

    The behavior of following the most in vogue and admired styles of dressing has been there since the ancient times. With time, people have moved on with the rapid change in the surroundings. Both the genders acknowledge fashion. Fashion is an extension of regular clothing. This paper investigates the role of economical players which includes per capita income and inflations in shaping up the various trends/ fashion trends/ trends in clothing and their consumptions for Pakistan, India, United S...

  12. Concussion among Swedish elite ice hockey players.

    OpenAIRE

    Tegner, Y; Lorentzon, R

    1996-01-01

    OBJECTIVE: To evaluate the frequency of concussion in Swedish ice hockey and to establish a uniform grading and treatment model for concussions of different severity. METHODS: Frequency of concussion was investigated in two studies, one retrospective and one prospective. In the retrospective study, all Swedish elite ice hockey players (n = 265) were asked to answer a questionnaire on the number and treatment of previous concussions. Only concussions diagnosed by a doctor were recorded. The qu...

  13. Dysadherin: a new player in cancer progression.

    OpenAIRE

    Nam, Jeong-Seok; Hirohashi, Setsuo; Wakefield, Lalage M.

    2007-01-01

    Dysadherin is a cancer-associated cell membrane glycoprotein that promotes experimental cancer metastasis. Here we review recent work that has provided insights into possible mechanisms of action of this newly recognized player in the cancer progression process. Dysadherin modulates cell phenotype in a number of ways, including down-regulation of E-cadherin-mediated cell adhesion, and up-regulation of chemokine production. In this way, expression of dysadherin in a tumor can influence both th...

  14. Tennis elbow: incidence in local league players.

    OpenAIRE

    Carroll, R.

    1981-01-01

    Seventy-four local league players were surveyed through a questionnaire and interview to establish the incidence of tennis elbow, the perceived causes, preventive measures taken and their perceived effectiveness. Of these 35% suffered from tennis elbow, 77% of those critically. The tennis racquet used, technique and timing and the condition of the court were perceived as the main causes, whilst playing tennis frequently was seen as the main contributory factor. The effectiveness of both medic...

  15. Statistical Analysis of Player Behavior in Minecraft

    OpenAIRE

    Müller, S; Kapadia, M; Frey, S.; Klinger, S.; Mann, RP; Solenthaler, B; Sumner, RW; Gross, M.

    2015-01-01

    Interactive Virtual Worlds offer new individual and social experiences in a huge variety of artificial realities. They also have enormous potential for the study of how people interact, and how societies function and evolve. Systematic collection and analysis of in-play behavioral data will be invaluable for enhancing player experiences, facilitating effective administration, and unlocking the scientific potential of online societies. This paper details the development of a framework to colle...

  16. Apoptosis and inflammation

    Directory of Open Access Journals (Sweden)

    C. Haanen

    1995-01-01

    Full Text Available During the last few decades it has been recognized that cell death is not the consequence of accidental injury, but is the expression of a cell suicide programme. Kerr et al. (1972 introduced the term apoptosis. This form of cell death is under the influence of hormones, growth factors and cytokines, which depending upon the receptors present on the target cells, may activate a genetically controlled cell elimination process. During apoptosis the cell membrane remains intact and the cell breaks into apoptotic bodies, which are phagocytosed. Apoptosis, in contrast to necrosis, is not harmful to the host and does not induce any inflammatory reaction. The principal event that leads to inflammatory disease is cell damage, induced by chemical/physical injury, anoxia or starvation. Cell damage means leakage of cell contents into the adjacent tissues, resulting in the capillary transmigration of granulocytes to the injured tissue. The accumulation of neutrophils and release of enzymes and oxygen radicals enhances the inflammatory reaction. Until now there has been little research into the factors controlling the accumulation and the tissue load of granulocytes and their histotoxic products in inflammatory processes. Neutrophil apoptosis may represent an important event in the control of intlamtnation. It has been assumed that granulocytes disintegrate to apoptotic bodies before their fragments are removed by local macrophages. Removal of neutrophils from the inflammatory site without release of granule contents is of paramount importance for cessation of inflammation. In conclusion, apoptotic cell death plays an important role in inflammatory processes and in the resolution of inflammatory reactions. The facts known at present should stimulate further research into the role of neutrophil, eosinophil and macrophage apoptosis in inflammatory diseases.

  17. Effects of plyometric training on soccer players

    Science.gov (United States)

    Wang, Ying-Chun; Zhang, Na

    2016-01-01

    Plyometric training (PT) is a technique used to increase strength and explosiveness. It consists of physical exercises in which muscles exert maximum force at short intervals to increase dynamic performances. In such a training, muscles undergo a rapid elongation followed by an immediate shortening (stretch-shortening contraction), utilizing the elastic energy stored during the stretching phase. There is consensus on the fact that when used, PT contributes to improvement in vertical jump performance, acceleration, leg strength, muscular power, increase of joint awareness and overall sport-specific skills. Consequently, PT which was primarily used by martial artists, sprinters and high jumpers to improve performances has gained in popularity and has been used by athletes in all types of sports. However, although PT has been shown to increase performance variables in many sports, little scientific information is currently available to determine whether PT actually enhances skill performance in soccer players, considering that soccer is an extremely demanding sport. Soccer players require dynamic muscular performance for fighting at all levels of training status, including rapid movements such as acceleration and deceleration of the body, change of direction, vertical and horizontal jumps, endurance, speed as well as power for kicking and tackling. In this review we discussed the effects of PT on soccer players by considering gender and age categories.

  18. Relations of Control: Walkthroughs and the Structuring of Player Agency

    Directory of Open Access Journals (Sweden)

    James Newman

    2010-07-01

    Full Text Available Videogame walkthroughs provide instructions on various elements of gameplay in relation to specific digital games, and exist as text-based documents and, to a lesser extent, as recorded moving image game footage. We focus here on written-walkthroughs for the purposes of depth, while recognising the specific and significant position that moving image walkthroughs hold (see Ashton, forthcoming. Player-produced walkthroughs, freely and widely distributed online, point to the broader social contexts that inform and structure player agency. In this article, we emphasize three perspectives on these documents. First, walkthroughs can be approached as a means of recording and codifying playing styles, thereby legitimising specific approaches or strategies. Accordingly, we highlight glitch hunting and the Pokémon series to illustrate the diversity of these playing styles and the significance of the walkthrough as a form of ludic archival document. Second, walkthroughs as textual codifications of gameplay potential can encourage new styles of engagement with authors and performers by outlining opportunities for play, and illuminating strategies and techniques previously unknown to the reader. Importantly, as we shall demonstrate, walkthroughs not only investigate and interrogate game texts – exploring their every narrative turn and spatial aspects in minute detail – but also frequently present techniques that take advantage of weaknesses and flaws in the ruleset or code of the game in order to offer new gameplay options. In this respect, as James Newman (2008 suggests, walkthroughs can be understood as a form of reverse-engineering that renegotiates the player-designer relationship and encourages (perhaps even demands deliberately investigative, resistant and deviant strategies of gameplay. These modes of engagement frequently involve playing beyond performative norms and technical limits. The walkthrough, then, is both a document of the game as

  19. Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue

    OpenAIRE

    Cardoso, Luis; Herman, Brad C.; Verborgt, Olivier; Laudier, Damien; Majeska, Robert J.; Schaffler, Mitchell B.

    2008-01-01

    Osteocyte apoptosis is spatially and temporally linked to bone fatigue–induced microdamage and to subsequent intracortical remodeling. Specifically, osteocytes surrounding fatigue microcracks in bone undergo apoptosis, and those regions containing apoptotic osteocytes co-localize exactly with areas subsequently resorbed by osteoclasts. Here we tested the hypothesis that osteocyte apoptosis is a key controlling step in the activation and/or targeting of osteoclastic resorption after bone fatig...

  20. Apoptosis and the target genes of microRNA-21

    Institute of Scientific and Technical Information of China (English)

    Lindsey E. Becker Buscaglia; Yong Li

    2011-01-01

    MicroRNA-21 (miR-21) is frequently up-regulated in cancer and the majodty of its reported targets are tumor suppressors. Through functional suppression, miR-21 is implicated in practically every walk of oncogenic life: the promotion of cell proliferation, invasion and metastasis, genome instability and mutation, inflammation, replicative immortalization, abnormal metabolism, angiogenesis, and evading apoptosis, immune destruction, and growth suppressors. In particular, miR-21 is strongly involved in apoptosis. In this article, we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular apoptosis. This suggests that miR-21 is an oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21.

  1. Vascular Health in American Football Players: Cardiovascular Risk Increased in Division III Players

    Directory of Open Access Journals (Sweden)

    Deborah L. Feairheller

    2016-01-01

    Full Text Available Studies report that football players have high blood pressure (BP and increased cardiovascular risk. There are over 70,000 NCAA football players and 450 Division III schools sponsor football programs, yet limited research exists on vascular health of athletes. This study aimed to compare vascular and cardiovascular health measures between football players and nonathlete controls. Twenty-three athletes and 19 nonathletes participated. Vascular health measures included flow-mediated dilation (FMD and carotid artery intima-media thickness (IMT. Cardiovascular measures included clinic and 24 hr BP levels, body composition, VO2 max, and fasting glucose/cholesterol levels. Compared to controls, football players had a worse vascular and cardiovascular profile. Football players had thicker carotid artery IMT (0.49 ± 0.06 mm versus 0.46 ± 0.07 mm and larger brachial artery diameter during FMD (4.3±0.5 mm versus 3.7±0.6 mm, but no difference in percent FMD. Systolic BP was significantly higher in football players at all measurements: resting (128.2±6.4 mmHg versus 122.4±6.8 mmHg, submaximal exercise (150.4±18.8 mmHg versus 137.3±9.5 mmHg, maximal exercise (211.3±25.9 mmHg versus 191.4±19.2 mmHg, and 24-hour BP (124.9±6.3 mmHg versus 109.8±3.7 mmHg. Football players also had higher fasting glucose (91.6±6.5 mg/dL versus 86.6±5.8 mg/dL, lower HDL (36.5±11.2 mg/dL versus 47.1±14.8 mg/dL, and higher body fat percentage (29.2±7.9% versus 23.2±7.0%. Division III collegiate football players remain an understudied population and may be at increased cardiovascular risk.

  2. Fullerene and apoptosis

    Directory of Open Access Journals (Sweden)

    M. A. Orlova

    2013-01-01

    Full Text Available Fullerene derivatives superfamily attracts a serious attention as antiviral and anticancer agents and drug delivery carriers as well. A large number of such fullerene С60 derivatives obtained to date. However, there is an obvious deficit of information about causes and mechanisms of immediately and long-term consequences of their effects in vivo which is a true obstacle on the way leading to practical medical use of them. First, this concerns their impact on the proliferation, apoptosis and necrosis regulation. Fullerene nanoparticle functionalization type, their sizes and surface nanopathology are of great importance to further promoting of either cytoprotective or cytotoxic effects. This lecture provides modern concept analysis regarding fullerenes effects on apoptosis pathway in normal and tumor cells.

  3. Mitochondrial dynamics and apoptosis

    OpenAIRE

    Suen, Der-Fen; Norris, Kristi L.; Youle, Richard J.

    2008-01-01

    In healthy cells, mitochondria continually divide and fuse to form a dynamic interconnecting network. The molecular machinery that mediates this organelle fission and fusion is necessary to maintain mitochondrial integrity, perhaps by facilitating DNA or protein quality control. This network disintegrates during apoptosis at the time of cytochrome c release and prior to caspase activation, yielding more numerous and smaller mitochondria. Recent work shows that proteins involved in mitochondri...

  4. Apoptosis: una muerte silenciosa

    Directory of Open Access Journals (Sweden)

    Isis Casadelvalle Pérez

    2006-01-01

    Full Text Available La apoptosis o muerte celular programada es un tipo de muerte presente en todas las células eucarióticas. Es un proceso ordenado y esencial del desarrollo normal y de mantenimiento de la homeostasis de un organismo. En el presente trabajo se resumen las principales características fisiológicas, bioquímicas y moleculares de la muerte por apoptosis, evento que ocurre de forma apagada o silenciosa, o sea, sin daño celular aparente diferenciándose claramente del proceso de necrosis celular. En ese proceso se destaca la mitocondria, como organelo celular donde mediado por la activación de las caspasas se inicia el paso hacia la muerte celular programada. En el momento actual, la apoptosis ha cobrado un verdadero valor para la mejor comprensión de los procesos biológicos normales en los que este evento está involucrado y que con anterioridad no era tomado en cuenta. En este sentido, se comentan las principales técnicas de detección de muerte celular programada y se aclara que la elección de algunas de ellas depende del modelo de estudio. Tambi én se dan a conocer algunas de las patologías generales en las que este proceso representa un papel determinante y se discute acerca de cómo algunas alteraciones en los mecanismos de regulación de la apoptosis inducen la aparici ón de varias enfermedades, incluyendo aquellos desórdenes en los que ocurre acumulación celular (cáncer, alteración cardiaca, neurodegeneración y SIDA. El estudio y caracterización de este complejo mecanismo ha cambiado profundamente la comprensión de numerosas patologías en los organismos eucariotas.

  5. Exploring Game Performance in the National Basketball Association Using Player Tracking Data.

    Directory of Open Access Journals (Sweden)

    Jaime Sampaio

    Full Text Available Recent player tracking technology provides new information about basketball game performance. The aim of this study was to (i compare the game performances of all-star and non all-star basketball players from the National Basketball Association (NBA, and (ii describe the different basketball game performance profiles based on the different game roles. Archival data were obtained from all 2013-2014 regular season games (n = 1230. The variables analyzed included the points per game, minutes played and the game actions recorded by the player tracking system. To accomplish the first aim, the performance per minute of play was analyzed using a descriptive discriminant analysis to identify which variables best predict the all-star and non all-star playing categories. The all-star players showed slower velocities in defense and performed better in elbow touches, defensive rebounds, close touches, close points and pull-up points, possibly due to optimized attention processes that are key for perceiving the required appropriate environmental information. The second aim was addressed using a k-means cluster analysis, with the aim of creating maximal different performance profile groupings. Afterwards, a descriptive discriminant analysis identified which variables best predict the different playing clusters. The results identified different playing profile of performers, particularly related to the game roles of scoring, passing, defensive and all-round game behavior. Coaching staffs may apply this information to different players, while accounting for individual differences and functional variability, to optimize practice planning and, consequently, the game performances of individuals and teams.

  6. How Players Lose Interest in Playing a Game

    DEFF Research Database (Denmark)

    Bauckhage, Christian; Kersting, Kristian; Sifa, Rafet;

    2012-01-01

    Analyzing telemetry data of player behavior in computer games is a topic of increasing interest for industry and research, alike. When applied to game telemetry data, pattern recognition and statistical analysis provide valuable business intelligence tools for game development. An important problem...... introduce methods from random process theory into game data mining in order to draw inferences about player engagement. Given large samples (over 250,000 players) of behavioral telemetry data from five different action-adventure and shooter games, we extract information as to how long individual players...... in this area is to characterize how player engagement in a game evolves over time. Reliable models are of pivotal interest since they allow for assessing the long-term success of game products and can provide estimates of how long players may be expected to keep actively playing a game. In this paper, we...

  7. Intermittent Testing and Training for High-Level Football Players

    DEFF Research Database (Denmark)

    Ingebrigtsen, Jørgen

    four articles that focus on physical testing and training for elite and sub-elite football players.The first article (Study I) aims to identify and establish aerobic capacities and anthropometric characteristics of elite female football players with the use of laboratory tests, and to examine whether...... characteristics or aerobic capacitymeasures across the football player positions in female elite football players when we apply traditional laboratory tests (i.e. VO2max and anaerobic threshold). We speculate whether this may be caused by the parameters not being sufficiently sensitive to differentiate between...... traditional laboratory tests of physical fitness of football players are not suitable to detect physical differences between elite female football players in different playing positions. This indicates that they are not sufficiently related to the relevant physical parameters of each playing position (i...

  8. Using physiological measures in conjunction with other UX approaches for better understanding of the player's gameplay experiences

    CERN Document Server

    Mirza-Babaei, Pejman

    2011-01-01

    The goal of video games is to challenge and entertain the players. Successful video games deliver experience that impact players on a level of arousal. Therefore undertaking a user experience (UX) study is crucial to ensure that a game achieves both critical and financial success. However, traditional usability methods (observation, subjective reporting, questionnaire, and interview) have a number of limitations on game user research. In this study we capture player's physiological measures during a gameplay session, to indicate micro-events that have caused changes in their body signals. At the post-gameplay interviews we ask participants to comment and describe their feelings on the selected events. The aim of this study is not to over-interpret physiological measures, but on using blips in measures to help identify key points in a game, which we then use to investigate further with the participant. This approach provides a method that can identify not only the negative user experience and usability issues ...

  9. Monitoring load, recovery and performance in young elite soccer players

    OpenAIRE

    Brink, Michel S.; Nederhof, Esther; Visscher, Chris; Schmikli, Sandor L.; Lemmink, Koen A. P. M.

    2010-01-01

    Brink, MS, Nederhof, E, Visscher, C, Schmikli, SL, and Lemmink, KAPM. Monitoring load, recovery, and performance in young elite soccer players. J Strength Cond Res 24(3): 597603, 2010-The purpose of this study was to investigate the relation between training load, recovery, and monthly field test performance in young elite soccer players to develop training guidelines to enhance performance. In a prospective, non-experimental cohort design, 18 young elite soccer players registered training an...

  10. Heart rate and activity profile for young female soccer players

    OpenAIRE

    Barbero Álvarez, José Carlos; Gómez López, Maite; Barbero Álvarez, Verónica; Granda Vera, Juan; Castagna, Carlo

    2008-01-01

    The physical and physiological demands of high-level male soccer have been studied extensively, while few studies have investigated the demands placed on females during match-play, however, there is no information available about the heart rate and activity profile of young female soccer players during match play. Therefore, the aim of this study was to examine cardiovascular (heart-rates HR) and physical demands of young female soccer players during a match. Players were observed during a fr...

  11. Cryptographically Blinded Games: Leveraging Players' Limitations for Equilibria and Profit

    OpenAIRE

    Pavel Hub\\xe1ek; Sunoo Park

    2014-01-01

    In this work we apply methods from cryptography to enable any number of mutually distrusting players to implement broad classes of mediated equilibria of strategic games without the need for trusted mediation. Our implementation makes use of a (standard) pre-play "cheap talk" phase, in which players engage in free and non-binding communication prior to playing in the original game. In our cheap talk phase, the players execute a secure multi-party computation protocol to sample an action profi...

  12. A stakeholder assessment of basketball player evaluation metrics

    OpenAIRE

    Martínez García, José Antonio; Martínez Caro, Laura

    2011-01-01

    In this research we examined the opinions of basketball stakeholders regarding several questions of special interests to valuate players. Players, coaches, agents, journalists, editors, bloggers, researchers, analysts, fans and chairs participated in this macro-research. After analysing their opinions using the content analysis methodology, we found that current player evaluation systems are insufficient to fulfill the expectations of stakeholders regarding the definition of value, because th...

  13. Sex-specific differences in injury types among basketball players

    OpenAIRE

    Ito E; Iwamoto J; Azuma K; Matsumoto H

    2014-01-01

    Eri Ito, Jun Iwamoto, Koichiro Azuma, Hideo MatsumotoInstitute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, JapanAbstract: The purpose of the present study was to investigate sex-specific differences in injury types among basketball players. According to our database, during the 20-year period between October 1991 and June 2011, 1,219 basketball players (640 males and 579 females) consulted our sports medicine clinic; in total, 1,414 injuries in basketball player...

  14. Evaluation of knee braces in Swedish ice hockey players.

    OpenAIRE

    Tegner, Y; Lorentzon, R

    1991-01-01

    In this retrospective investigation we have determined the rate and types of knee injuries among Swedish ice hockey players, and related these data to the use of knee braces. Thirty-seven of the originally selected 50 hockey teams (74%) of elite or first division calibre took part in the study, and 600 players answered a questionnaire. A total of 254 previous knee injuries sustained while playing hockey were reported by 243 players; tears of the medical collateral ligament (60%), meniscus (15...

  15. Management of female handball players' activity applying interactive technologies

    OpenAIRE

    Frolova L.S.; Glazyrin I.D.; Petrenko Y.O.; Rudenko E.; Udod M.

    2012-01-01

    The efficiency of developed methods for the control of female handball players' readiness to competitive activity was determined. The opportunities of team management regarding the specification of playing role, the formation of the starting line of players and the replacement according to game priorities in attack or defense were considered. The availability of the adequate zone of handball players' mobilizing readiness that allows to have a significant influence on individual effectiveness ...

  16. Hardiness and Situation Efficacy at Elite Basketball Players

    OpenAIRE

    Sindik, Josko; Adzija, Maja

    2013-01-01

    The main aims of the study were: to explore the latent structure of the construct of hardiness at Croatian top basketball players and to gain an understanding of the relationship between obtained hardiness dimensions and situation-related efficacy in basketball. Situation efficacy of individual basketball players in top teams is linked to the constellation of a number of relevant anthropological and specific psychological features that influence the behavior of basketball players in stressful...

  17. Nutrition and hydration concerns of the female football player

    OpenAIRE

    Maughan, Ronald J; Shirreffs, Susan M

    2007-01-01

    There is little information on the nutritional habits of female football players at any level of the game. There is also a shortage of information on the nutrition and hydration strategies that players should adopt. In general, differences in nutritional needs between males and females are smaller than differences between individuals, so that principles developed for male players also apply to women. There is a need to address energy balance and body composition: prolonged energy deficits can...

  18. Trunk fatigue profile and low back pain in tennis players

    OpenAIRE

    Correia, José Pedro

    2013-01-01

    Mestrado em Ciências da Fisioterapia Introduction The trunk plays an important role in tennis strokes. Its asymmetric muscle activation, coupled with the high repeatability of the sport, places tennis players at risk for injuries such as low back pain. Objectives This study aimed to present a trunk fatigue profile in tennis players and verify its association with low back pain (LBP). Material and Methods 35 tennis players completed an isometric trunk endurance protocol co...

  19. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers

    Science.gov (United States)

    Cobb, Laura J.; Lee, Changhan; Xiao, Jialin; Yen, Kelvin; Wong, Richard G.; Nakamura, Hiromi K.; Mehta, Hemal H.; Gao, Qinglei; Ashur, Carmel; Huffman, Derek M.; Wan, Junxiang; Muzumdar, Radhika; Barzilai, Nir; Cohen, Pinchas

    2016-01-01

    Mitochondria are key players in aging and in the pathogenesis of age-related diseases. Recent mitochondrial transcriptome analyses revealed the existence of multiple small mRNAs transcribed from mitochondrial DNA (mtDNA). Humanin (HN), a peptide encoded in the mtDNA 16S ribosomal RNA region, is a neuroprotective factor. An in silico search revealed six additional peptides in the same region of mtDNA as humanin; we named these peptides small humanin-like peptides (SHLPs). We identified the functional roles for these peptides and the potential mechanisms of action. The SHLPs differed in their ability to regulate cell viability in vitro. We focused on SHLP2 and SHLP3 because they shared similar protective effects with HN. Specifically, they significantly reduced apoptosis and the generation of reactive oxygen species, and improved mitochondrial metabolism in vitro. SHLP2 and SHLP3 also enhanced 3T3-L1 pre-adipocyte differentiation. Systemic hyperinsulinemic-euglycemic clamp studies showed that intracerebrally infused SHLP2 increased glucose uptake and suppressed hepatic glucose production, suggesting that it functions as an insulin sensitizer both peripherally and centrally. Similar to HN, the levels of circulating SHLP2 were found to decrease with age. These results suggest that mitochondria play critical roles in metabolism and survival through the synthesis of mitochondrial peptides, and provide new insights into mitochondrial biology with relevance to aging and human biology. PMID:27070352

  20. Making star teams out of star players.

    Science.gov (United States)

    Mankins, Michael; Bird, Alan; Root, James

    2013-01-01

    Top talent is an invaluable asset: In highly specialized or creative work, for instance, "A" players are likely to be six times as productive as "B" players. So when your company has a crucial strategic project, why not multiply all that firepower and have a team of your best performers tackle it? Yet many companies hesitate to do this, believing that all-star teams don't work: Big egos will get in the way. The stars won't be able to work with one another. They'll drive the team Leader crazy. Mankins, Bird, and Root of Bain & Company believe it's time to set aside that thinking. They have seen all-star teams do extraordinary work. But there is a right way and a wrong way to organize them. Before you can even begin to assemble such a team, you need to have the right talent management practices, so you hire and develop the best people and know what they're capable of. You have to give the team appropriate incentives and leaders and support staffers who are stars in their own right. And projects that are ill-defined or small scale are not for all-star teams. Use them only for critical missions, and make sure their objectives are clear. Even with the right setup, things can still go wrong. The wise executive will take steps to manage egos, prune non-team-players, and prevent average coworkers from feeling completely undervalued. She will also invest a lot of time in choosing the right team Leader and will ask members for lots of feedback to monitor how that leader is doing. PMID:23390743

  1. A dynamic game of a transboundary pollutant with asymmetric players

    International Nuclear Information System (INIS)

    Modeling transboundary pollutants in a dynamic game framework provides a foundation for analyzing the impact of various policy options. The focus of this analysis is on the results of a tax/subsidy scheme used to address the transboundary problem of global climate change. A nonzero-sum dynamic game with asymmetric players is used to evaluate the policy impact of the tax/subsidy scheme on the respective player's value functions and strategies as determined by a Nash equilibrium feedback solution. The asymmetry of the players is reflected in their respective attitudes toward global climate change with one player benefiting from the change and the other losing. 17 refs., 5 tabs

  2. Towards Player Adaptivity in a Serious Game for Conflict Resolution

    DEFF Research Database (Denmark)

    Grappiolo, C.; Cheong, Yun-Gyung; Togelius, J.;

    2011-01-01

    to resolve this type of conflict, the underlying system generates level content automatically which adapts to player experience and behaviour. Preliminary results demonstrate the efficiency of the procedural content generation mechanism in guiding the training of players towards targeted learning......We present a technology demonstrator for an adaptive serious game for teaching conflict resolution and discuss the research questions associated with the project. The prototype is a single-player 3D mini-game which simulates a resource management conflict scenario. In order to teach the player how...

  3. Enhancements for Multi-Player Monte-Carlo Tree Search

    Science.gov (United States)

    Nijssen, J. (Pim) A. M.; Winands, Mark H. M.

    Monte-Carlo Tree Search (MCTS) is becoming increasingly popular for playing multi-player games. In this paper we propose two enhancements for MCTS in multi-player games: (1) Progressive History and (2) Multi-Player Monte-Carlo Tree Search Solver (MP-MCTS-Solver). We analyze the performance of these enhancements in two different multi-player games: Focus and Chinese Checkers. Based on the experimental results we conclude that Progressive History is a considerable improvement in both games and MP-MCTS-Solver, using the standard update rule, is a genuine improvement in Focus.

  4. Arthroscopic Shoulder Surgery in Female Professional Tennis Players

    Science.gov (United States)

    Young, Simon W.; Safran, Marc R.; Dakic, Jodie; Nguyen, Michael L.; Stroia, Kathleen

    2013-01-01

    Objectives: Recent publications have highlighted the relatively poor outcome of other overhead athletes, particularly baseball players, with regard to return to sports at the same or higher level after shoulder surgery. However, true assessment of their ability when returning to sport is not as clear. Further, ability to return to other overhead sports has not been reported. Our objective was to assess outcome and time to return to previous level of function following shoulder surgery in professional tennis players. Methods: The records of all female tennis players on the Women’s Tennis Association (WTA) professional circuit between January 2008 and June 2010 were reviewed to identify players who underwent shoulder surgery on their dominant (serving) shoulder. Details of the surgery including date, procedures performed, and complications were recorded. The primary outcomes were ability and time to return to professional play, and if they were able to return to their previous level of function, as determined by singles ranking. Pre and post-operative singles rankings were used to determine rate and completeness of return to preoperative function. Their highest ranking pre-injury, post operatively, and the time to return to pre-injury ranking were evaluated. Results: During the study period eight professional women tennis players from the WTA underwent shoulder surgery on their dominant arm. All surgery was performed arthroscopically, 7 out of 8 players had more than one procedure performed during the surgery. In total, 3 players underwent debridement of a partial rotator cuff tear and 2 players underwent repair of a complete supraspinatus tear. Three players had an anterior labral repair or reconstruction for anterior instability, and one player underwent repair of a SLAP lesion. Two players underwent neurolysis of a suprascapular nerve, and three players in total underwent a subacromial decompression. All players (100%) returned to professional play. The mean

  5. Cervical spine injuries in rugby players.

    Science.gov (United States)

    Sovio, O M; Van Peteghem, P K; Schweigel, J F

    1984-03-15

    Nine patients with serious cervical spine injuries that occurred while they were playing rugby were seen in a British Columbia acute spinal cord injury unit during the period 1975-82. All the injuries had occurred during the "scrum" or the "tackle". Two of the patients were rendered permanently quadriplegic, and one patient died. There is a need for a central registry that would record all cervical spine injuries in rugby players as well as for changes in the rules of the game. PMID:6697282

  6. Predicting Player Churn In the Wild

    DEFF Research Database (Denmark)

    Hadiji, Fabian; Sifa, Rafet; Drachen, Anders;

    2014-01-01

    Free-to-Play or "freemium" games represent a fundamental shift in the business models of the game industry, facilitated by the increasing use of online distribution platforms and the introduction of increasingly powerful mobile platforms. The ability of a game development company to analyze and...... derive insights from behavioral telemetry is crucial to the success of these games which rely on in-game purchases and in-game advertising to generate revenue, and for the Company to remain competitive in a global marketplace. The ability to model, understand and predict future player behavior has a...

  7. Motivation and Sport Injuries in Handball Players

    OpenAIRE

    Laguna, María; Blas, Amador; Olmedilla, Aurelio

    2010-01-01

    The aim of the study was to test whether different levels of motivation are related to the injuries suffered by elite athletes. The sample consists of 80 professional handball players of ASOBAL League, with a mean age of 24.83 years (+ 5.21). Motivation was assessed through the CPRD scale (Gimeno, Buceta & Pérez-Llantada; 1999) and a self-report questionnaire was used to register sports injuries. The results indicate that there is a relationship between motivational levels and the risk for in...

  8. Fibular Fracture in a Female Rugby Player.

    Science.gov (United States)

    Mendola, Jonathan A; Johnson, Michael; Goss, Don

    2016-07-01

    A 20-year-old female rugby player was injured when an opponent landed on her leg during a match. Twelve days after injury, the team's certified athletic trainer referred the patient to a physical therapist due to continued pain. Following fluoroscopic imaging, which was utilized by the physical therapist because standard radiographs were unavailable in close proximity, she was referred for radiographs, which demonstrated a midfibular diaphyseal fracture. J Orthop Sports Phys Ther 2016;46(7):608. doi:10.2519/jospt.2016.0411. PMID:27363575

  9. Isolated and painless (? atrophy of the infraspinatus muscle: left handed versus right handed volleyball players

    Directory of Open Access Journals (Sweden)

    Thiago D. Gonçalves Côelho

    1994-12-01

    Full Text Available The suprascapular nerve originates from the upper trunk of the brachial plexus or less frequently from the root of C5. It runs a short way and crosses the suprascapular notch. It innervates the supraspinatus muscle and the acromioclavicular and glenohumeral joints. Then, it crosses the lateral edge of the spine of the scapula passing through the spinoglenoid notch, and innervates the infraspinatus muscle. These are potential sites of injury to the suprascapular nerve. Three cases of suprascapular nerve entrapment causing an isolated infraspinatus muscle atrophy in volleyball players were studied. It is suggested the hypothesis that the nature of the smash, in which the athlete uses the arm violently, more than does in volleyball service or in the art of reception, is the key to the pathogenesis of the lesion in volleyball players.

  10. Racism in soccer ? Perception of challenges of black and white players by white referees, soccer players, and fans.

    OpenAIRE

    Wagner-Egger, Pascal; Gygax, Pascal; Ribordy, Farfalla

    2014-01-01

    This experiment investigated challenge evaluations in soccer and their relation to prejudice: more precisely, whether skin colour may influence judgements of soccer tackles. Three groups of participants (soccer players, referees and soccer fans) were asked to evaluate challenges, featuring Black and White players as aggressors and victims in a mixed-design study. Results showed that participants made some differentiations between Black and White players in a challenge evaluation task. Partici...

  11. ANALYSIS AND COMPARISON OF ADOLESCENT ATHLETES' MOTIVATION: BASKETBALL PLAYERS VS. FOOTBALL PLAYERS

    Directory of Open Access Journals (Sweden)

    Bartolom\\u00E9 J. Almagro

    2009-01-01

    Full Text Available The motivation of an athlete is determinant for the athletic engagement of the adolescent. The present study attempts to analyze the motivation of adolescent basketball and football players from the perspectives of Achievement Goal Theory (Nicholls, 1989 and Self-Determination Theory (Deci & Ryan, 1985. The study's sample was composed of 248 athletes from 12 to 17 years of age. Half were from basketball and half were from football. The instruments that were utilized were: the Spanish version of the Sport Motivation Scale (SMS (Núñez, Martín-Albo, Navarro, & González, 2006, the Spanish version of the Perceived Motivational Climate in Sport Questionnaire-2 (PMSCQ-2 (Balaguer, Mayo, Atienza, & Duda, 1997, and the adapted Spanish translation (Moreno, Moreno, & Cervelló, 2007 of the Intention to be Physically Active Scale (IPAS by Hein, Müür, and Koka (2004. The comparison of the means of the variables between football and basketball players was done utilizing the student t-test for independent samples. Significant differences were found for variables such as: intrinsic motivation (IM toward accomplishment, external regulation, amotivation, task, ego, and Self-Determination Index (SDI. Basketball players obtained higher values in the SDI, in task, and in IM toward accomplishment than football players. The search for premature performance in football and coaches' educations can help to explain these differences. The importance of these differences reside in the relationship between these motivational variables and the adherence to athletic practice. In conclusion, basketball demonstrated better values in motivational variables, which demonstrates that training sessions are more oriented toward task than ego, that players have more intrinsic and self-determined motivation, and therefore, the adherence of the young athletes will be greater in this sport.

  12. Sport commitment in adolescent soccer players

    Directory of Open Access Journals (Sweden)

    Noelia Belando Pedreño

    2016-03-01

    Full Text Available The aim of this study was to contribute to the postulates of the self-determination theory, the hierarchical model of intrinsic and extrinsic motivation by Vallerand, and social goals. A structural regression model was estimated to analyze the relations between social goals (responsibility and relationships, praise for autonomous behavior, satisfaction of the basic psychological needs and intrinsic motivation in commitment to sport. A sample of 264 young Spanish soccer players aged between 14 and 16 (M =14.74, SD =.77 participated in the study. Structural Equation Modeling results showed that the social responsibility goal, the social relationship goal and praise for autonomous behavior predicted perceived competence. Furthermore, the relationship goal also predicted the need for relatedness. Satisfaction of the basic psychological needs for competence and relatedness predicted intrinsic motivation. Intrinsic motivation positively predicted future commitment to sport. These results highlighted the importance of social goals, praise for autonomous behavior and psychological mediators in encouraging greater commitment in young soccer players. Future research should focus on the coach’s role in generating greater commitment to sport through the development of intervention methodologies based on social goals.

  13. Scapula Kinematics of Youth Baseball Players

    Directory of Open Access Journals (Sweden)

    Oliver Gretchen

    2015-12-01

    Full Text Available Literature has revealed the importance of quantifying resting scapular posture in overhead athletes as well as quantifying scapular kinematics during dynamic movement. Prior to this project much of the attention in throwing research had been focused on the position of the humerus without description of the positioning of the scapula. Therefore, it was the purpose of this study to present scapular kinematics during pitching in youth baseball players. Twenty-five youth baseball players (age 11.3 + 1.0 years; body height 152.4 + 9.0 cm; body mass 47.5 + 11.3 kg, with no history of injury, participated in the study. Scapular kinematics at the events of maximum humeral external rotation (MER and maximum humeral internal rotation (MIR during the pitching motion were assessed three-dimensionally while pitching fastballs for strikes. Results revealed that at the event of MER, the scapula was in a position of retraction, upward rotation and a posterior tilt. While at the event of MIR, the scapula was protracted, upward rotated and tilted anteriorly.

  14. Sex-specific differences in injury types among basketball players

    Directory of Open Access Journals (Sweden)

    Ito E

    2014-12-01

    Full Text Available Eri Ito, Jun Iwamoto, Koichiro Azuma, Hideo MatsumotoInstitute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, JapanAbstract: The purpose of the present study was to investigate sex-specific differences in injury types among basketball players. According to our database, during the 20-year period between October 1991 and June 2011, 1,219 basketball players (640 males and 579 females consulted our sports medicine clinic; in total, 1,414 injuries in basketball players (729 injuries in males and 685 injuries in females were recorded. The mean age of patients was 19.6 years. The most common injury site was the knee, followed by the foot and ankle, lower back, and upper extremities. There was a higher proportion of female players presenting with a knee injury, compared with male players (50.4% vs 41.7%, and a lower proportion of female players presenting with an upper extremity injury (5.1% vs 9.7%. The proportion of anterior cruciate ligament injury in the 10–19-year-old age group was higher among female players than among male players (45.9% vs 22.1%, while the proportions of Osgood–Schlatter disease in the 10–19-year-old age group and jumper's knee (patellar and femoral tendinopathy in the 20–29-year-old age group were higher among male players than among female players (12.5% vs 1.8% and 14.6% vs 3.7%, respectively. However, the proportions of other injuries did not differ significantly between male and female players. The present observational study, which was performed using a retrospective case-series design, showed the existence of sex-specific differences in knee injuries sustained while participating in basketball.Keywords: sports injury, sex, anterior cruciate ligament injury, Osgood–Schlatter disease, basketball

  15. N-player quantum games in an EPR setting.

    Directory of Open Access Journals (Sweden)

    James M Chappell

    Full Text Available The N-player quantum games are analyzed that use an Einstein-Podolsky-Rosen (EPR experiment, as the underlying physical setup. In this setup, a player's strategies are not unitary transformations as in alternate quantum game-theoretic frameworks, but a classical choice between two directions along which spin or polarization measurements are made. The players' strategies thus remain identical to their strategies in the mixed-strategy version of the classical game. In the EPR setting the quantum game reduces itself to the corresponding classical game when the shared quantum state reaches zero entanglement. We find the relations for the probability distribution for N-qubit GHZ and W-type states, subject to general measurement directions, from which the expressions for the players' payoffs and mixed Nash equilibrium are determined. Players' N x N payoff matrices are then defined using linear functions so that common two-player games can be easily extended to the N-player case and permit analytic expressions for the Nash equilibrium. As a specific example, we solve the Prisoners' Dilemma game for general N ≥ 2. We find a new property for the game that for an even number of players the payoffs at the Nash equilibrium are equal, whereas for an odd number of players the cooperating players receive higher payoffs. By dispensing with the standard unitary transformations on state vectors in Hilbert space and using instead rotors and multivectors, based on Clifford's geometric algebra (GA, it is shown how the N-player case becomes tractable. The new mathematical approach presented here has wide implications in the areas of quantum information and quantum complexity, as it opens up a powerful way to tractably analyze N-partite qubit interactions.

  16. Apoptosis and DNA Methylation

    Directory of Open Access Journals (Sweden)

    Richard R. Meehan

    2011-04-01

    Full Text Available Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.

  17. Labor Market Structure and Salary Determination among Professional Basketball Players.

    Science.gov (United States)

    Wallace, Michael

    1988-01-01

    The author investigates the labor market structure and determinants of salaries for professional basketball players. An expanded version of the resource perspective is used. A three-tiered model of labor market segmentation is revealed for professional basketball players, but other variables also are important in salary determination. (Author/CH)

  18. Player Collaboration in the Explorative Sound Environment ToneInk

    DEFF Research Database (Denmark)

    Hansen, Anne-Marie; Andersen, Hans Jørgen; Raudaskoski, Pirkko Liisa

    2016-01-01

    In the present paper, ToneInk, a prototype of a music based play scenario that investigates player collaboration, is introduced. ToneInk is an explorative sound environment that differs from the majority of music based games in that players can collaborate and be creative in the way they express...

  19. Little League Baseball and Players' Self-Esteem.

    Science.gov (United States)

    Hawkins, Donna B.; Gruber, Joseph J.

    1982-01-01

    The effect of a season of little league baseball on the self-esteem of 94 pre-adolescent players was investigated. The Coopersmith Self-esteem Inventory and a newly devised Baseball-Self scale were administered. Significant improvements in players' total Self-esteem, Home-Parents and School-Academic scores were found. (Author/PN)

  20. Differences in Soccer Kick Kinematics between Blind Players and Controls

    Science.gov (United States)

    Giagazoglou, Paraskevi; Katis, Athanasios; Kellis, Eleftherios; Natsikas, Christos

    2011-01-01

    The purpose of the current study was to examine the kinematic differences during instep soccer kicks between players who were blind and sighted controls. Eleven male soccer players who were blind and nine male sighted performed instep kicks under static and dynamic conditions. The results indicated significantly higher (p less than 0.05) ball…

  1. The Mental Skills Training of University Soccer Players

    Science.gov (United States)

    Sadeghi, Hassan; Omar-Fauzee, Mohd-Sofian; Jamalis, Marjohan; Ab-Latif, Rozita; Cheric, Majid Chahrdah

    2010-01-01

    The purpose of this study is to identify the kind of mental skills training needed most by the university soccer players. Eight male university football players (aged 25 to 36) from one large university in Kuala Lumpur agreed to participate in this study. On average, they have 10 years of playing experience. All of them have signed the informed…

  2. Development of repeated sprint ability in talented youth basketball players.

    NARCIS (Netherlands)

    Wierike, S.C. te; Jong, M.C. de; Tromp, E.J.; Vuijk, P.J.; Lemmink, K.A.; Malina, R.M.; Elferink-Gemser, M.T.; Visscher, C.

    2013-01-01

    Factors affecting repeated sprint ability (RSA) were evaluated in a mixed-longitudinal sample of 48 elite basketball players 14 to 19 years of age (16.1±1.7 years). Players were observed on six occasions during the 2008-2009 and 2009-2010 seasons. Three basketball-specific field tests were administe

  3. Gender Differences in Coping among Elite Table Tennis Players

    Science.gov (United States)

    Kirimoglu, Huseyin

    2011-01-01

    The current study aims to investigate the explanatory power of social support and coping in relation to a competitive sport event between male and female table tennis players. 246 university students table tennis players (120 men and 126 women) from different region and part of Turkey were invited to participate in a survey study included the…

  4. A Comparison of Methods for Player Clustering via Behavioral Telemetry

    DEFF Research Database (Denmark)

    Drachen, Anders; Thurau, Christian; Sifa, Rafet;

    2013-01-01

    The analysis of user behavior in digital games has been aided by the introduction of user telemetry in game development, which provides unprecedented access to quantitative data on user behavior from the installed game clients of the entire population of players. Player behavior telemetry datasets...

  5. Apoptosis Resistance in Endometriosis

    Directory of Open Access Journals (Sweden)

    Liselotte Mettler

    2011-08-01

    Full Text Available Introduction: In a cytological analysis of endometriotic lesions neither granulocytes nor cytotoxic T-cells appear in an appreciable number. Based on this observation we aimed to know, whether programmed cell death plays an essential role in the destruction of dystopic endometrium. Disturbances of the physiological mechanisms of apoptosis, a persistence of endometrial tissue could explain the disease. Another aspect of this consideration is the proliferation competence of the dystopic mucous membrane. Methods: Endometriotic lesions of 15 patients were examined through a combined measurement of apoptosis activity with the TUNEL technique (terminal deoxyribosyltransferase mediated dUTP Nick End Labeling and the proliferation activity (with the help of the Ki-67-Antigens using the monoclonal antibody Ki-S5. Results: Twelve out of 15 women studied showed a positive apoptotic activity of 3-47% with a proliferation activity of 2-25% of epithelial cells. Therefore we concluded that the persistence of dystopic endometrium requires proliferative epithelial cells from middle to lower endometrial layers. Conclusion: A dystopia misalignment of the epithelia of the upper layers of the functionalism can be rapidly eliminated by apoptotic procedures.

  6. The system of world golf ranking among amateur players - WAGR

    Directory of Open Access Journals (Sweden)

    Tereshchuk M.V.

    2014-11-01

    Full Text Available Purpose: justify the particular rating-WAGR and determine its value. Material: More than 40 references, including analysis of 8 protocols of Ukraine competition in golf. Results: The features and significance of the world rankings in golf among amateur players. Displaying ranking tournaments in accordance with the system of WAGR and justified the use of the conversion of the results to determine the specific places the player in the rankings. In Ukraine, held six WAGR-Tournament, the first tournament was held in 2011. Today in the world ranking of amateur players is one player from the Ukraine. Conclusions: It was found that the top-WAGR determines the level of development of the national golf federations and influence in the international arena. For the selection of athletes for the summer Youth Olympic Games is used world-rated golf amateur players (WAGR among boys and girls.

  7. Apoptosis : Target of cancer therapy

    NARCIS (Netherlands)

    Ferreira, CG; Epping, M; Kruyt, FAE; Giaccone, G

    2002-01-01

    Recent knowledge on apoptosis has made it possible to devise novel approaches, which exploit this process to treat cancer. In this review, we discuss in detail approaches to induce tumor cell apoptosis, their mechanism of action, stage of development, and possible drawbacks. Finally, the obstacles y

  8. Nuclear Apoptosis Contributes to Sarcopenia

    OpenAIRE

    Alway, Stephen E.; Parco M. Siu

    2008-01-01

    Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia.

  9. Self-synthesizing transposons: unexpected key players in the evolution of viruses and defense systems.

    Science.gov (United States)

    Krupovic, Mart; Koonin, Eugene V

    2016-06-01

    Self-synthesizing transposons are the largest known transposable elements that encode their own DNA polymerases (DNAP). The Polinton/Maverick family of self-synthesizing transposons is widespread in eukaryotes and abundant in the genomes of some protists. In addition to the DNAP and a retrovirus-like integrase, most of the polintons encode homologs of the major and minor jelly-roll capsid proteins, DNA-packaging ATPase and capsid maturation protease. Therefore, polintons are predicted to alternate between the transposon and viral lifestyles although virion formation remains to be demonstrated. Polintons are related to a group of eukaryotic viruses known as virophages that parasitize on giant viruses of the family Mimiviridae and another recently identified putative family of polinton-like viruses (PLV) predicted to lead a similar, dual life style. Comparative genomic analysis of polintons, virophages, PLV and the other viruses with double-stranded (ds)DNA genomes infecting eukaryotes and prokaryotes suggests that the polintons evolved from bacterial tectiviruses and could have been the ancestors of a broad range of eukaryotic viruses including adenoviruses and members of the proposed order 'Megavirales' as well as linear cytoplasmic plasmids. Recently, a group of predicted self-synthesizing transposons was discovered also in prokaryotes. These elements, denoted casposons, encode a DNAP and a homolog of the CRISPR-associated Cas1 endonuclease that has an integrase activity but no capsid proteins. Thus, unlike polintons, casposons appear to be limited to the transposon life style although they could have evolved from viruses. The casposons are thought to have played a pivotal role in the origin of the prokaryotic adaptive immunity, giving rise to the adaptation module of the CRISPR-Cas systems. PMID:26836982

  10. Misconstrued versatility of Ganoderma lucidum: a key player in multi-targeted cellular signaling.

    Science.gov (United States)

    Gill, Balraj Singh; Sharma, Prateek; Kumar, Raj; Kumar, Sanjeev

    2016-03-01

    A Basidiomycetes fungus belonging to polypore family of mushrooms, Ganoderma lucidum (GL), has been known since a long time for their myriad therapeutic indications. Renowned as an invaluable resource of cardinal mycoconstituents they encompass numerous terpenoids polysaccharides and proteins. Possessing the therapeutically potent lanosteroidal skeleton, terpenoids are upheld for their invariable participation in therapeutically diverse bioactivities. Polysaccharides and proteins exhibiting distinguishable bioactivities provide this oriental mushroom with additional edges over immune function and anti-cancer potential. This review is a concerted effort to throw light upon the therapeutic versatility of the fungus, shadowed by various other natural products. An effort has been made towards conglomerating the mycoconstituents decisive for the many activities portrayed by this fungus. More importantly, this review seeks to fathom the inextricable role played by derivatives in modulating signaling cascades such as downregulation of various mitogenic pathways, inhibiting growth factors, or upregulating certain pathways enhancing cellular integrity. PMID:26715282

  11. Diversity of key players in the microbial ecosystems of the human body

    OpenAIRE

    Ferenc Jordán; Mario Lauria; Marco Scotti; Thanh-Phuong Nguyen; Paurush Praveen; Melissa Morine; Corrado Priami

    2015-01-01

    Coexisting bacteria form various microbial communities in human body parts. In these ecosystems they interact in various ways and the properties of the interaction network can be related to the stability and functional diversity of the local bacterial community. In this study, we analyze the interaction network among bacterial OTUs in 11 locations of the human body. These belong to two major groups. One is the digestive system and the other is the female genital tract. In each local ecosystem...

  12. Current Management Strategies in Breast Cancer by Targeting Key Altered Molecular Players.

    Science.gov (United States)

    Ali, Shazia; Mondal, Neelima; Choudhry, Hani; Rasool, Mahmood; Pushparaj, Peter N; Khan, Mohammad A; Mahfooz, Maryam; Sami, Ghufrana A; Jarullah, Jummanah; Ali, Ashraf; Jamal, Mohammad S

    2016-01-01

    Breast cancer is the second largest disease affecting women worldwide. It remains the most frequently reported and leading cause of death among women in both developed and developing countries. Tamoxifen and raloxifene are commonly used selective estrogen receptor modulators for treatment of breast cancer in women with high risk, although resistance occurs by tamoxifen after 5 years of therapy and both drugs cause uterine cancer and thromboembolic events. Aromatase inhibitors (AIs) are one of the optional modes used for breast cancer treatment. The combination of AIs along with tamoxifen can also be beneficial. Various therapeutic agents from different sources are being studied, which further need to be improved for potential outcome. For this, clinical trials based on large number of patients with optimal dose and lesser side effects have to be more in practice. Despite the clinical trials going on, there is need of better molecular models, which can identify high risk population, new agents with better benefit having less side effects, and improved biomarkers for treating breast cancer. PMID:26973813

  13. Animal Models of Diabetic Macrovascular Complications: Key Players in the Development of New Therapeutic Approaches

    Directory of Open Access Journals (Sweden)

    Suvi E. Heinonen

    2015-01-01

    Full Text Available Diabetes mellitus is a lifelong, incapacitating metabolic disease associated with chronic macrovascular complications (coronary heart disease, stroke, and peripheral vascular disease and microvascular disorders leading to damage of the kidneys (nephropathy and eyes (retinopathy. Based on the current trends, the rising prevalence of diabetes worldwide will lead to increased cardiovascular morbidity and mortality. Therefore, novel means to prevent and treat these complications are needed. Under the auspices of the IMI (Innovative Medicines Initiative, the SUMMIT (SUrrogate markers for Micro- and Macrovascular hard end points for Innovative diabetes Tools consortium is working on the development of novel animal models that better replicate vascular complications of diabetes and on the characterization of the available models. In the past years, with the high level of genomic information available and more advanced molecular tools, a very large number of models has been created. Selecting the right model for a specific study is not a trivial task and will have an impact on the study results and their interpretation. This review gathers information on the available experimental animal models of diabetic macrovascular complications and evaluates their pros and cons for research purposes as well as for drug development.

  14. Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease.

    Science.gov (United States)

    Cherubini, Marta; Puigdellívol, Mar; Alberch, Jordi; Ginés, Silvia

    2015-10-01

    The molecular mechanisms underlying striatal vulnerability in Huntington's disease (HD) are still unknown. However, growing evidence suggest that mitochondrial dysfunction could play a major role. In searching for a potential link between striatal neurodegeneration and mitochondrial defects we focused on cyclin-dependent kinase 5 (Cdk5). Here, we demonstrate that increased mitochondrial fission in mutant huntingtin striatal cells can be a consequence of Cdk5-mediated alterations in Drp1 subcellular distribution and activity since pharmacological or genetic inhibition of Cdk5 normalizes Drp1 function ameliorating mitochondrial fragmentation. Interestingly, mitochondrial defects in mutant huntingtin striatal cells can be worsened by D1 receptor activation a process also mediated by Cdk5 as down-regulation of Cdk5 activity abrogates the increase in mitochondrial fission, the translocation of Drp1 to the mitochondria and the raise of Drp1 activity induced by dopaminergic stimulation. In sum, we have demonstrated a new role for Cdk5 in HD pathology by mediating dopaminergic neurotoxicity through modulation of Drp1-induced mitochondrial fragmentation, which underscores the relevance for pharmacologic interference of Cdk5 signaling to prevent or ameliorate striatal neurodegeneration in HD. PMID:26143143

  15. The transcription factor Pokemon: a new key player in cancer pathogenesis.

    Science.gov (United States)

    Maeda, Takahiro; Hobbs, Robin M; Pandolfi, Pier Paolo

    2005-10-01

    Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics. PMID:16204018

  16. Grassroots Activists and the Three Branches of Government: "Key Players in the Civil Rights Movement"

    Science.gov (United States)

    Brown, Elizabeth; Silvestri, Linda

    2014-01-01

    In order to understand the complex workings of the three branches of American government, young citizens need early exposure in the elementary years to hands-on lessons that include real life examples and opportunities for students to apply what they have learned. To that end, the authors designed a five-day, inquiry-based unit for fourth grade…

  17. From Prostate to Bone: Key Players in Prostate Cancer Bone Metastasis

    OpenAIRE

    Thobe, Megan N.; Rinker-Schaeffer, Carrie W.; Clark, Robert J; Bainer, Russell O.; Prasad, Sandip M.

    2011-01-01

    Bone is the most common site for metastasis in human prostate cancer patients. Skeletal metastases are a significant cause of morbidity and mortality and overall greatly affect the quality of life of prostate cancer patients. Despite advances in our understanding of the biology of primary prostate tumors, our knowledge of how and why secondary tumors derived from prostate cancer cells preferentially localize bone remains limited. The physiochemical properties of bone, and signaling molecules ...

  18. From Prostate to Bone: Key Players in Prostate Cancer Bone Metastasis

    International Nuclear Information System (INIS)

    Bone is the most common site for metastasis in human prostate cancer patients. Skeletal metastases are a significant cause of morbidity and mortality and overall greatly affect the quality of life of prostate cancer patients. Despite advances in our understanding of the biology of primary prostate tumors, our knowledge of how and why secondary tumors derived from prostate cancer cells preferentially localize bone remains limited. The physiochemical properties of bone, and signaling molecules including specific chemokines and their receptors, are distinct in nature and function, yet play intricate and significant roles in prostate cancer bone metastasis. Examining the impact of these facets of bone metastasis in vivo remains a significant challenge, as animal models that mimic the natural history and malignant progression clinical prostate cancer are rare. The goals of this article are to discuss (1) characteristics of bone that most likely render it a favorable environment for prostate tumor cell growth, (2) chemokine signaling that is critical in the recruitment and migration of prostate cancer cells to the bone, and (3) current animal models utilized in studying prostate cancer bone metastasis. Further research is necessary to elucidate the mechanisms underlying the extravasation of disseminated prostate cancer cells into the bone and to provide a better understanding of the basis of cancer cell survival within the bone microenvironment. The development of animal models that recapitulate more closely the human clinical scenario of prostate cancer will greatly benefit the generation of better therapies

  19. Gender Quota inside the Boardroom: Female Directors as New Key Players?

    OpenAIRE

    Rebérioux, Antoine; Roudaut, Gwenaël

    2016-01-01

    This paper examines whether women’s situation within French boards has improved following theadoption of a board-level gender quota in 2011. To do so, we focus on the individual role of femaledirectors as proxied by their fees. Our sample includes the listed companies belonging to the SBF120index over the 2006-2014 period. We first show that the quota has succeeded in opening the doors ofboardrooms to new, unseasoned female directors (not present on the director labor market before theregulat...

  20. mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse.

    Science.gov (United States)

    Neasta, Jeremie; Barak, Segev; Hamida, Sami Ben; Ron, Dorit

    2014-07-01

    The mammalian (or mechanistic) target of rapamycin (mTOR) complex 1 (mTORC1) is a serine and threonine kinase that regulates cell growth, survival, and proliferation. mTORC1 is a master controller of the translation of a subset of mRNAs. In the central nervous system mTORC1 plays a crucial role in mechanisms underlying learning and memory by controlling synaptic protein synthesis. Here, we review recent evidence suggesting that the mTORC1 signaling pathway promotes neuroadaptations following exposure to a diverse group of drugs of abuse including stimulants, cannabinoids, opiates, and alcohol. We further describe potential molecular mechanisms by which drug-induced mTORC1 activation may alter brain functions. Finally, we propose that mTORC1 is a focal point shared by drugs of abuse to mediate drug-related behaviors such as reward seeking and excessive drug intake, and offer future directions to decipher the contribution of the kinase to mechanisms underlying addiction. Recent studies suggesting that exposure to diverse classes of drugs of abuse as well as exposure to drug-associated memories lead to mTORC1 kinase activation in the limbic system. In turn, mTORC1 controls the onset and the maintenance of pathological neuroadaptions that underlie several features of drug addiction such as drug seeking and relapse. Therefore, we propose that targeting mTORC1 and its effectors is a promising strategy to treat drug disorders. PMID:24666346

  1. Women are key players in the economies of East and Southeast Asia.

    Science.gov (United States)

    Westley, S B; Mason, A

    1998-01-01

    In 1996, the East-West Center's Program on Population investigated the links between population change and economic growth in Japan, South Korea, Taiwan, Singapore, Thailand, and Indonesia. This document discusses the findings pertaining to women's changing marriage and childbearing patterns, education attainment, and labor force participation as well as changes in family life. In eastern and southeastern Asia, women are delaying marriage and having fewer children as a result of their overwhelming acceptance of modern contraception. Concurrently, women's secondary school enrollment has increased dramatically since 1960, and women have accounted for steadily increasing proportions of total labor force growth. Economic development has led to fewer women employed in agriculture and more in clerical positions. Women continue to be marginalized in low-paying manufacturing jobs and to lose these jobs more frequently than do men. Women's labor force participation continues to be dependent upon their child care responsibilities, but women are beginning to combine both activities with the help of live-in grandparents. Women have made an important contribution to economic growth in Asia. Policies should address job discrimination against married women, wage discrimination, the problems faced by young women who leave home for employment in the manufacturing and service sectors, and the lack of child care facilities. PMID:12293729

  2. Using the Gene Ontology to Annotate Key Players in Parkinson's Disease.

    Science.gov (United States)

    Foulger, R E; Denny, P; Hardy, J; Martin, M J; Sawford, T; Lovering, R C

    2016-07-01

    The Gene Ontology (GO) is widely recognised as the gold standard bioinformatics resource for summarizing functional knowledge of gene products in a consistent and computable, information-rich language. GO describes cellular and organismal processes across all species, yet until now there has been a considerable gene annotation deficit within the neurological and immunological domains, both of which are relevant to Parkinson's disease. Here we introduce the Parkinson's disease GO Annotation Project, funded by Parkinson's UK and supported by the GO Consortium, which is addressing this deficit by providing GO annotation to Parkinson's-relevant human gene products, principally through expert literature curation. We discuss the steps taken to prioritise proteins, publications and cellular processes for annotation, examples of how GO annotations capture Parkinson's-relevant information, and the advantages that a topic-focused annotation approach offers to users. Building on the existing GO resource, this project collates a vast amount of Parkinson's-relevant literature into a set of high-quality annotations to be utilized by the research community. PMID:26825309

  3. Intrapituitary mechanisms underlying the control of fertility: key players in seasonal breeding.

    Science.gov (United States)

    Tortonese, D J

    2016-07-01

    Recent studies have shown that, in conjunction with dynamic changes in the secretion of GnRH from the hypothalamus, paracrine interactions within the pituitary gland play an important role in the regulation of fertility during the annual reproductive cycle. Morphological studies have provided evidence for close associations between gonadotropes and lactotropes and gap junction coupling between these cells in a variety of species. The physiological significance of this cellular interaction was supported by subsequent studies revealing the expression of prolactin receptors in both the pars distalis and pars tuberalis regions of the pituitary. This cellular interaction is critical for adequate gonadotropin output because, in the presence of dopamine, prolactin can negatively regulate the LH response to GnRH. Receptor signaling studies showed that signal convergence at the level of protein kinase C and phospholipase C within the gonadotrope underlies the resulting inhibition of LH secretion. Although this is a conserved mechanism present in all species studied so far, in seasonal breeders such as the sheep and the horse, this mechanism is regulated by photoperiod, as it is only apparent during the long days of spring and summer. At this time of year, the nonbreeding season of the sheep coincides with the breeding season of the horse, indicating that this inhibitory system plays different roles in short- and long-day breeders. Although in the sheep, it contributes to the complete suppression of the reproductive axis, in the horse, it is likely to participate in the fine-tuning of gonadotropin output by preventing gonadotrope desensitization. The photoperiodic regulation of this inhibitory mechanism appears to rely on alterations in the folliculostellate cell population. Indeed, electron microscopic studies have recently shown increased folliculostellate cell area together with upregulation of their adherens junctions during the spring and summer. The association between gonadotropes and lactotropes could also underlie an interaction between the gonadotropic and prolactin axes in the opposite direction. In support of this alternative, a series of studies have demonstrated that GnRH stimulates prolactin secretion in sheep through a mechanism that does not involve the mediatory actions of LH or FSH and that this stimulatory effect of GnRH on the prolactin axis is seasonally regulated. Collectively, these findings highlight the importance of intercellular communications within the pituitary in the control of gonadotropin and prolactin secretion during the annual reproductive cycle in seasonal breeders. PMID:27345316

  4. Key players in the genetic switch of bacteriophage TP901-1.

    Science.gov (United States)

    Alsing, Anne; Pedersen, Margit; Sneppen, Kim; Hammer, Karin

    2011-01-19

    After infection of a sensitive host temperate phages may enter either a lytic or a lysogenic pathway leading to new phage assembly or silencing as a prophage, respectively. The decision about which pathway to enter is centered in the genetic switch of the phage. In this work, we explore the bistable genetic switch of bacteriophage TP901-1 through experiments and statistical mechanical modeling. We examine the activity of the lysogenic promoter P(R) at different concentrations of the phage repressor, CI, and compare the effect of CI on P(R) in the presence or absence of the phage-encoded MOR protein expressed from the lytic promoter P(L). We find that the presence of large amounts of MOR prevents repression of the P(R) promoter, verifying that MOR works as an antirepressor. We compare our experimental data with simulations based on previous mathematical formulations of this switch. Good agreement between data and simulations verify the model of CI repression of P(R). By including MOR in the simulations, we are able to discard a model that assumes that CI and MOR do not interact before binding together at the DNA to repress P(R). The second model of Pr repression assumes the formation of a CI:MOR complex in the cytoplasm. We suggest that a CI:MOR complex may exist in different forms that either prevent or invoke P(R) repression, introducing a new twist on mixed feedback systems. PMID:21244827

  5. NF-κB and STAT3-key players in liver inflammation and cancer

    Institute of Scientific and Technical Information of China (English)

    Guobin He; Michael Karin

    2011-01-01

    Hepatocellular carcinoma(HCC),the major form of primary liver cancer,is one of the most deadly human cancers.The pathogenesis of HCC is frequently linked with continuous hepatocyte death,inflammatory cell infiltration and compensatory liver regeneration.Understanding the molecular signaling pathways driving or mediating these processes during liver tumorigenesis is important for the identification of novel therapeutic targets for this dreadful disease.The classical IKKβ-dependent NF-κB signaling pathway has been shown to promote hepatocyte survival in both developing and adult livers.In addition,it also plays a crucial role in liver inflammatory responses by controlling the expression of an array of growth factors and cytokines.One of these cytokines is IL-6,which is best known for its role in the liver acute phase response.IL-6 exerts many of its functions via activation of STAT3,a transcription factor found to be important for HCC development.This review will focus on recent studies on the roles of NF-κB and STAT3 in liver cancer.Interactions between the two pathways and their potential as therapeutic targets will also be discussed.

  6. Key players and team play: anaerobic microbial communities in hydrocarbon-contaminated aquifers.

    Science.gov (United States)

    Kleinsteuber, Sabine; Schleinitz, Kathleen M; Vogt, Carsten

    2012-05-01

    Biodegradation of anthropogenic pollutants in shallow aquifers is an important microbial ecosystem service which is mainly brought about by indigenous anaerobic microorganisms. For the management of contaminated sites, risk assessment and control of natural attenuation, the assessment of in situ biodegradation and the underlying microbial processes is essential. The development of novel molecular methods, "omics" approaches, and high-throughput techniques has revealed new insight into complex microbial communities and their functions in anoxic environmental systems. This review summarizes recent advances in the application of molecular methods to study anaerobic microbial communities in contaminated terrestrial subsurface ecosystems. We focus on current approaches to analyze composition, dynamics, and functional diversity of subsurface communities, to link identity to activity and metabolic function, and to identify the ecophysiological role of not yet cultured microbes and syntrophic consortia. We discuss recent molecular surveys of contaminated sites from an ecological viewpoint regarding degrader ecotypes, abiotic factors shaping anaerobic communities, and biotic interactions underpinning the importance of microbial cooperation for microbial ecosystem services such as contaminant degradation. PMID:22476263

  7. ABA, ROS and NO are Key Players During Switchgrass Seed Germination

    OpenAIRE

    Sarath, Gautam; Hou, Guichuan; Baird, Lisa M.; Robert B Mitchell

    2007-01-01

    Seed dormancy and germination are complex physiological processes usually under hormonal control. Germination of seeds from many plants including switchgrass, are inhibited by ABA and promoted by NO or ROS. However, ABA apparently requires both ROS and NO as intermediates in its action, with ROS produced by membrane-bound NADPH-oxidases responsive to ABA. In switchgrass seeds, externally supplied hydrogen peroxide (ROS), but not NO will overcome ABA-imposed inhibition of germination. Stimulat...

  8. Fructose as a key player in the development of fatty liver disease.

    Science.gov (United States)

    Basaranoglu, Metin; Basaranoglu, Gokcen; Sabuncu, Tevfik; Sentürk, Hakan

    2013-02-28

    We aimed to investigate whether increased consumption of fructose is linked to the increased prevalence of fatty liver. The prevalence of nonalcoholic steatohepatitis (NASH) is 3% and 20% in nonobese and obese subjects, respectively. Obesity is a low-grade chronic inflammatory condition and obesity-related cytokines such as interleukin-6, adiponectin, leptin, and tumor necrosis factor-α may play important roles in the development of nonalcoholic fatty liver disease (NAFLD). Additionally, the prevalence of NASH associated with both cirrhosis and hepatocellular carcinoma was reported to be high among patients with type 2 diabetes with or without obesity. Our research group previously showed that consumption of fructose is associated with adverse alterations of plasma lipid profiles and metabolic changes in mice, the American Lifestyle-Induced Obesity Syndrome model, which included consumption of a high-fructose corn syrup in amounts relevant to that consumed by some Americans. The observation reinforces the concerns about the role of fructose in the obesity epidemic. Increased availability of fructose (e.g., high-fructose corn syrup) increases not only abnormal glucose flux but also fructose metabolism in the hepatocyte. Thus, the anatomic position of the liver places it in a strategic buffering position for absorbed carbohydrates and amino acids. Fructose was previously accepted as a beneficial dietary component because it does not stimulate insulin secretion. However, since insulin signaling plays an important role in central mechanisms of NAFLD, this property of fructose may be undesirable. Fructose has a selective hepatic metabolism, and provokes a hepatic stress response involving activation of c-Jun N-terminal kinases and subsequent reduced hepatic insulin signaling. As high fat diet alone produces obesity, insulin resistance, and some degree of fatty liver with minimal inflammation and no fibrosis, the fast food diet which includes fructose and fats produces a gene expression signature of increased hepatic fibrosis, inflammation, endoplasmic reticulum stress and lipoapoptosis. Hepatic de novo lipogenesis (fatty acid and triglyceride synthesis) is increased in patients with NAFLD. Stable-isotope studies showed that increased de novo lipogenesis (DNL) in patients with NAFLD contributed to fat accumulation in the liver and the development of NAFLD. Specifically, DNL was responsible for 26% of accumulated hepatic triglycerides and 15%-23% of secreted very low-density lipoprotein triglycerides in patients with NAFLD compared to an estimated less than 5% DNL in healthy subjects and 10% DNL in obese people with hyperinsulinemia. In conclusion, understanding the underlying causes of NAFLD forms the basis for rational preventive and treatment strategies of this major form of chronic liver disease. PMID:23482247

  9. Stem cell therapy emerging as the key player in treating type 1 diabetes mellitus.

    Science.gov (United States)

    Vanikar, Aruna V; Trivedi, Hargovind L; Thakkar, Umang G

    2016-09-01

    Type 1 diabetes mellitus (T1DM) is an autoimmune disease causing progressive destruction of pancreatic β cells, ultimately resulting in loss of insulin secretion producing hyperglycemia usually affecting children. Replacement of damaged β cells by cell therapy can treat it. Currently available strategies are insulin replacement and islet/pancreas transplantation. Unfortunately these offer rescue for variable duration due to development of autoantibodies. For pancreas/islet transplantation a deceased donor is required and various shortfalls of treatment include quantum, cumbersome technique, immune rejection and limited availability of donors. Stem cell therapy with assistance of cellular reprogramming and β-cell regeneration can open up new therapeutic modalities. The present review describes the history and current knowledge of T1DM, evolution of cell therapies and different cellular therapies to cure this condition. PMID:27424148

  10. Wound cleansing: a key player in the implementation of the TIME paradigm.

    Science.gov (United States)

    Pilcher, Matthew

    2016-03-01

    The concept of wound bed preparation can be implemented using the TIME paradigm. Chronic wounds are mostly characterised by prolonged inflammation and increased bioburden. Removal of wound biofilm and devitalised tissue, which is an ideal environment for bacterial growth, can help address the I in TIME. Wound cleansing aims to remove contaminants, debris, dressing remnants and superficial slough from the wound. Some wound cleansers contain surfactants, which reduce the surface tension of a liquid, enabling it to spread further over a surface. This article describes how these solutions can be used to debride the wound surface without damaging healthy cells. PMID:26949864

  11. PIP2: A new key player in nucleolar structure and transcription of ribosomal genes?

    Czech Academy of Sciences Publication Activity Database

    Yildirim, Sukriye; Castano, Enrique; Philimonenko, Vlada; Dzijak, Rastislav; Sobol, Margaryta; Hozák, Pavel

    Urbino : Italian Society of Microscopical Sciences, 2011. s. 263-263. [Multinational Congress on Microscopy /10./. 04.09.2011-09.09.2011, Urbino] R&D Projects: GA MŠk LC545; GA MŠk(CZ) LC06063; GA ČR GAP305/11/2232; GA ČR(CZ) GD204/09/H084 Institutional research plan: CEZ:AV0Z50520514 Keywords : nanoparticles * immunogold detection * cell nucleus * histochemistry Subject RIV: EB - Genetics ; Molecular Biology

  12. Heme metabolism in stress regulation and protein production: from Cinderella to a key player

    DEFF Research Database (Denmark)

    Martínez, J. L.; Petranovic, D.; Nielsen, Jens

    2016-01-01

    Heme biosynthesis is a highly conserved pathway which is present in all kingdoms, from Archaea to higher organisms such as plants and mammals. The heme molecule acts as a prosthetic group for different proteins and enzymes involved in energy metabolism and reactions involved in electron transfer....... Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its...

  13. Target of Rapamycin Is a Key Player for Auxin Signaling Transduction in Arabidopsis.

    Science.gov (United States)

    Deng, Kexuan; Yu, Lihua; Zheng, Xianzhe; Zhang, Kang; Wang, Wanjing; Dong, Pan; Zhang, Jiankui; Ren, Maozhi

    2016-01-01

    Target of rapamycin (TOR), a master sensor for growth factors and nutrition availability in eukaryotic species, is a specific target protein of rapamycin. Rapamycin inhibits TOR kinase activity viaFK506 binding protein 12 kDa (FKBP12) in all examined heterotrophic eukaryotic organisms. In Arabidopsis, several independent studies have shown that AtFKBP12 is non-functional under aerobic condition, but one study suggests that AtFKBP12 is functional during anaerobic growth. However, the functions of AtFKBP12 have never been examined in parallel under aerobic and anaerobic growth conditions so far. To this end, we cloned the FKBP12 gene of humans, yeast, and Arabidopsis, respectively. Transgenic plants were generated, and pharmacological examinations were performed in parallel with Arabidopsis under aerobic and anaerobic conditions. ScFKBP12 conferred plants with the strongest sensitivity to rapamycin, followed by HsFKBP12, whereas AtFKBP12 failed to generate rapamycin sensitivity under aerobic condition. Upon submergence, yeast and human FKBP12 can significantly block cotyledon greening while Arabidopsis FKBP12 only retards plant growth in the presence of rapamycin, suggesting that hypoxia stress could partially restore the functions of AtFKBP12 to bridge the interaction between rapamycin and TOR. To further determine if communication between TOR and auxin signaling exists in plants, yeast FKBP12 was introduced into DR5::GUS homozygous plants. The transgenic plants DR5/BP12 were then treated with rapamycin or KU63794 (a new inhibitor of TOR). GUS staining showed that the auxin content of root tips decreased compared to the control. DR5/BP12 plants lost sensitivity to auxin after treatment with rapamycin. Auxin-defective phenotypes, including short primary roots, fewer lateral roots, and loss of gravitropism, occurred in DR5/BP12 plants when seedlings were treated with rapamycin+KU63794. This indicated that the combination of rapamycin and KU63794 can significantly inhibit TOR and auxin signaling in DR5/BP12 plants. These studies demonstrate that TOR is essential for auxin signaling transduction in Arabidopsis. PMID:27014314

  14. Mucosal biomarkers in inflammatory bowel disease:Key pathogenic players or disease predictors?

    Institute of Scientific and Technical Information of China (English)

    Franco; Scaldaferrii; Carmen; Correale; Antonio; Gasbarrini; Silvio; Danese

    2010-01-01

    Inflammatory bowel diseases(IBDs) are chronic inflammatory disorders of the bowel,including ulcerative colitis and Crohn's disease.A single etiology has not been identified,but rather the pathogenesis of IBD is very complex and involves several major and minor contributors,employing different inflammatory pathways which have different roles in different patients.Although new and powerful medical treatments are available,many are biological drugs or immunosuppressants,which are associated with significant si...

  15. Solute transporters in plant thylakoid membranes: Key players during photosynthesis and light stress

    OpenAIRE

    Spetea, Cornelia; Schoefs, Benoît

    2010-01-01

    Plants utilize sunlight to drive photosynthetic energy conversion in the chloroplast thylakoid membrane. Here are located four major photosynthetic complexes, about which we have great knowledge in terms of structure and function. However, much less we know about auxiliary proteins, such as transporters, ensuring an optimum function and turnover of these complexes. The most prominent thylakoid transporter is the proton-translocating ATP-synthase. Recently, four additional transporters have be...

  16. KEY PLAYERS IN INNATE IMMUNE RECOGNITION OF VIRUS INFECTION IN MAMMALS AND FISH

    OpenAIRE

    I Jakovlić; Y. B. Zhang; Q.J. Wu; Jian-Fang Gui

    2006-01-01

    Viral infection of mammalian cells activates an innate antiviral immune response characterized by production of interferon and subsequent enhanced transcription of interferon–stimulated genes important for antiviral defense. Cells recognize viral infection through various pathogen–associated molecular patterns, of which dsRNA seems to be the most important. In mammals, several gene products are important in recognition of dsRNA: RIG–I, TLR3, PKR and mda–5. Recent research proved that fish pos...

  17. Post-translational modifications are key players of the Legionella pneumophila infection strategy

    Science.gov (United States)

    Michard, Céline; Doublet, Patricia

    2015-01-01

    Post-translational modifications (PTMs) are widely used by eukaryotes to control the enzymatic activity, localization or stability of their proteins. Traditionally, it was believed that the broad biochemical diversity of the PTMs is restricted to eukaryotic cells, which exploit it in extensive networks to fine-tune various and complex cellular functions. During the last decade, the advanced detection methods of PTMs and functional studies of the host–pathogen relationships highlight that bacteria have also developed a large arsenal of PTMs, particularly to subvert host cell pathways to their benefit. Legionella pneumophila, the etiological agent of the severe pneumonia legionellosis, is the paradigm of highly adapted intravacuolar pathogens that have set up sophisticated biochemical strategies. Among them, L. pneumophila has evolved eukaryotic-like and rare/novel PTMs to hijack host cell processes. Here, we review recent progress about the diversity of PTMs catalyzed by Legionella: ubiquitination, prenylation, phosphorylation, glycosylation, methylation, AMPylation, and de-AMPylation, phosphocholination, and de-phosphocholination. We focus on the host cell pathways targeted by the bacteria catalyzed PTMs and we stress the importance of the PTMs in the Legionella infection strategy. Finally, we highlight that the discovery of these PTMs undoubtedly made significant breakthroughs on the molecular basis of Legionella pathogenesis but also lead the way in improving our knowledge of the eukaryotic PTMs and complex cellular processes that are associated to. PMID:25713573

  18. Biomass power industry: Assessment of key players and approaches for DOE and industry interaction

    International Nuclear Information System (INIS)

    This report reviews the status of the US biomass power industry. The topics of the report include current fuels and the problems associated with procuring, transporting, preparing and burning them, competition from natural gas projects because of the current depressed natural gas prices, need for incentives for biomass fueled projects, economics, market potential and expansion of US firms overseas

  19. A Method for Using Player Tracking Data in Basketball to Learn Player Skills and Predict Team Performance.

    Directory of Open Access Journals (Sweden)

    Brian Skinner

    Full Text Available Player tracking data represents a revolutionary new data source for basketball analysis, in which essentially every aspect of a player's performance is tracked and can be analyzed numerically. We suggest a way by which this data set, when coupled with a network-style model of the offense that relates players' skills to the team's success at running different plays, can be used to automatically learn players' skills and predict the performance of untested 5-man lineups in a way that accounts for the interaction between players' respective skill sets. After developing a general analysis procedure, we present as an example a specific implementation of our method using a simplified network model. While player tracking data is not yet available in the public domain, we evaluate our model using simulated data and show that player skills can be accurately inferred by a simple statistical inference scheme. Finally, we use the model to analyze games from the 2011 playoff series between the Memphis Grizzlies and the Oklahoma City Thunder and we show that, even with a very limited data set, the model can consistently describe a player's interactions with a given lineup based only on his performance with a different lineup.

  20. Bone Mineral Density of Adolescent Female Tennis Players and Nontennis Players

    Directory of Open Access Journals (Sweden)

    Kevser Ermin

    2012-01-01

    Full Text Available The purpose of this study was to determine differences in bone mineral density (BMD among adolescent female tennis players (TPs and nontennis players (NTPs and to assess body composition as a predictor variable of BMD. Nineteen female TPs and 19 female NTPs, ages 14 to 18 years, participated in this study. Lumbar spine, total hip, femoral neck, forearms BMD, and body composition were assessed using dual-energy X-ray absorptiometry (DXA. Lumbar spine and total hip BMD measurements for TP were greater than NTP. However, these differences were not statistically significant (=0.37 and 0.12, resp.. TP had significantly greater femoral neck BMD than NTPs (=0.02. This difference might play an important role in preventing osteoporosis and decreasing the risk of fractures at the hip later in life.

  1. Caspase Family Proteases and Apoptosis

    Institute of Scientific and Technical Information of China (English)

    Ting-Jun FAN; Li-Hui HAN; Ri-Shan CONG; Jin LIANG

    2005-01-01

    Apoptosis, or programmed cell death, is an essential physiological process that plays a critical role in development and tissue homeostasis. The progress of apoptosis is regulated in an orderly way by a series of signal cascades under certain circumstances. The caspase-cascade system plays vital roles in the induction, transduction and amplification of intracellular apoptotic signals. Caspases, closely associated with apoptosis, are aspartate-specific cysteine proteases and members of the interleukin-1β-converting enzyme family. The activation and function of caspases, involved in the delicate caspase-cascade system, are regulated by various kinds of molecules, such as the inhibitor of apoptosis protein, Bcl-2 family proteins, calpain,and Ca2+. Based on the latest research, the members of the caspase family, caspase-cascade system and caspase-regulating molecules involved in apoptosis are reviewed.

  2. Dynamics of Internal Models in Game Players

    CERN Document Server

    Taiji, M; Taiji, Makoto; Ikegami, Takashi

    1998-01-01

    A new approach for the study of social games and communications is proposed. Games are simulated between cognitive players who build the opponent's internal model and decide their next strategy from predictions based on the model. In this paper, internal models are constructed by the recurrent neural network (RNN), and the iterated prisoner's dilemma game is performed. The RNN allows us to express the internal model in a geometrical shape. The complicated transients of actions are observed before the stable mutually defecting equilibrium is reached. During the transients, the model shape also becomes complicated and often experiences chaotic changes. These new chaotic dynamics of internal models reflect the dynamical and high-dimensional rugged landscape of the internal model space.

  3. Gamification in Fostering Creativity: Player Type Approach

    Directory of Open Access Journals (Sweden)

    Marius Kalinauskas

    2015-02-01

    Full Text Available Purpose – to analyze gamification, as the method for promoting creativity in individual and collective levels with the respect to player types.Design/methodology/approach – This research serves as a general review/viewpoint which seeks to examine collective creativity as a phenomenon and gamification as the tool for promoting individual and collective creativity. The paper is based on the comparative analysis of scientific literature and related sources from game design, psychology, business and entertainment.Findings – Although the gamification is gaining more public attention, there is a lack of studies which would reveal its relations in fostering individual and collective creativity. One of the main goals of any gamified content is to raise the engagement into activities in non-game contexts. The objective of creative work is to come up with some ideas, methods or tools which would be significantly new and innovative in the case of a certain issue. The theory of “flow” is used widely in explaining the working principles of gamification. In this state, the information absorption rates are increased and the group or individual is immersed into performed activities. This may lead to prolonged periods while accumulating knowledge, and thus, improving creative capabilities in the specific domain. However, creative performance in different fields has various approaches. It is also related to personal characteristics. The success of gamification is also dependent on the types of “players” which participate in the activity. Having the common picture of personality type in creative performance and in game based tasks may allow creating gamification strategy for optimal engagement into creative work according to the features of a person.Research limitations/implications – There are very few empirical studies which would support correlation between experiencing the “flow” state and a raise of creativity. The idea of unified

  4. Coping with stress and social support: A comparison between chess players and non-chess players

    OpenAIRE

    Jana Krivec

    2005-01-01

    Stress situations continue to represent an important factor of everyday life. The significance and role of stress are even greater in competitive sports. If not dealt with effectively, the pressure and demands of stress can reach proportions that seriously endanger the competitor. In the present study I examined the types of strategies chess players use in coping with stress situations during a single game aswell as through an entire tournament. In order to attain success, they need to overco...

  5. ANALYSIS AND COMPARISON OF ADOLESCENT ATHLETES' MOTIVATION: BASKETBALL PLAYERS VS. FOOTBALL PLAYERS

    OpenAIRE

    Bartolom\\u00E9 J. Almagro; Cristina Conde; Moreno, Juan A; Pedro S\\u00E1enz-L\\u00F3pez

    2009-01-01

    The motivation of an athlete is determinant for the athletic engagement of the adolescent. The present study attempts to analyze the motivation of adolescent basketball and football players from the perspectives of Achievement Goal Theory (Nicholls, 1989) and Self-Determination Theory (Deci & Ryan, 1985). The study's sample was composed of 248 athletes from 12 to 17 years of age. Half were from basketball and half were from football. The instruments that were utilized were: the Spanish versio...

  6. Effective conditioning of female soccer players.

    Science.gov (United States)

    Polman, Remco; Walsh, Darren; Bloomfield, Jonny; Nesti, Mark

    2004-02-01

    We compared the efficacy of three physical conditioning programmes provided over a 12 week period (24 h in total) on selected anthropometric and physical fitness parameters in female soccer players. Two of the groups received physical conditioning training in accordance with speed, agility and quickness (SAQ); one group used specialized resistance and speed development SAQ equipment (equipment group; n = 12), while the other group used traditional soccer coaching equipment (non-equipment group; n = 12). A third group received their regular fitness sessions (active control group; n = 12). All three interventions decreased (P training programme than those in the active control group by performing significantly better on the sprint to fatigue (-11.6% for both the equipment and non-equipment groups versus -6.2% for the active control group), 25 m sprint (-4.4% vs -0.7%), left (-4.5% vs -1.0%) and right (-4.0% vs -1.4%) side agility, and vertical (+18.5% vs +4.8%) and horizontal (+7.7% vs +1.6%) power tests. Some of these differences in improvements in physical fitness between the equipment and non-equipment conditioning groups on the one hand and the active control group on the other hand were probably due to the specificity of the training programmes. It was concluded that SAQ training principles appear to be effective in the physical conditioning of female soccer players. Moreover, these principles can be implemented during whole team training sessions without the need for specialized SAQ equipment. Finally, more research is required to establish the relationship between physical fitness and soccer performance as well as the principles underlying the improvements seen through the implementation of SAQ training programmes. PMID:14998097

  7. SPORTS SHOES PURCHASE INTENTION AMONG MALAYSIAN VOLLEYBALL PLAYERS VS. NON-VOLLEYBALL PLAYERS: A CONCEPTUAL PAPER

    Directory of Open Access Journals (Sweden)

    GOH PIN SIANG

    2013-12-01

    Full Text Available The purpose of this study is to advance the understanding of volleyball players’ purchase intention toward sport shoes by investigating the relationship between the independent variables (endorsement, advertising, pricing and electronic word-of-mouth and purchase intention. Descriptive research and causal research will be used as the research design, thus questionnaire and experimentation will be used to obtain data. Primary data in this study is attained by distributing the questionnaire to the Malaysian volleyball players throughout several volleyball tournament venues in Malaysia. The experiment will be conducted by comparing two groups of respondents, including volleyball players and non-volleyball players. This study is limited to several independent variables such as endorsement, advertising, pricing and electronic word-of-mouth. This study is significant for marketers for solving the challenges faced in the sport industry. It also helps to identify consumers’ purchase preferences for sport shoes. The marketer would understand more about their targeted customers’ intentions to purchase, thus the sport industry related with sport marketing in Malaysia might gain more profit.

  8. 论足球比赛中球员不同角色的定位%On Positioning of Different Roles for Football Game Players

    Institute of Scientific and Technical Information of China (English)

    岳正稳

    2012-01-01

    Players in football team are divided into key players, main players, characteristic players and bench players, among them, each has different status with different roles and functions. If a team wants to get achieve- ment, the couch must deal well with the relationships among roles and transformations from each other. In order to make the team efficient up to the extreme in the game and move forward, we should draw out the potential of every player and bring their superiority into full play with stimulating their initiatives.%球队有核心、主力、特色及替补球员之分,各自在队中的地位不同,所扮演的角色和作用也不一样。要想出成绩、创佳绩,就必须理顺好各角色之间的关系及他们之间的转变与转化,充分挖掘其潜质和潜力,发挥其特长和特点,调动其积极性,这样才能使球队在比赛中出效率并达到极致,球队才可持续向前发展。

  9. Key determinants of effective board of directors - evidence from Nigeria

    OpenAIRE

    Ogbechie, Christopher Ike

    2012-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. The 2008 financial crisis that led to the collapse of companies and economic recession in most countries has also increased the concern for transparency, accountability and regulatory oversight and once more put corporate governance and board effectiveness on the front burner of big business issues all over the world. The board is seen as a key player in governance of companies and there is n...

  10. Does competitive entry structurally change key marketing metrics.

    OpenAIRE

    2008-01-01

    To what extent does competitive entry create a structural change in key marketing metrics? New players may just be a temporal nuisance to incumbents, but could also fundamentally change the latter's performance evolution, or induce them to permanently alter their spending levels and/or pricing decisions. Similarly, the addition of a new marketing channel could permanently shift shopping preferences, or could just create a short-lived migration from existing channels. The steady-state impact o...

  11. A Novel Music Player Controlling Design Based on Gesture Recognition

    Directory of Open Access Journals (Sweden)

    Yi Liu

    2014-01-01

    Full Text Available This study has proposed a novel music player controlling method based on gesture recognition, which translating the gesture interacting signal into a controlling instruction for the music player. Firstly, utilizing the laptop’s webcam to capture the image information, and then employing the image processing method to tackle it. The skin color detection was used to obtain the information of gesture candidates, and a background subtraction was introduced to eliminate the distributing information. Moreover, in order to ensure the rapid and effective implementation of music player proposed here, the barycenter of a gesture was calculated as one Recognized Reference Information (RRI; a ratio between the gesture’s width and height was also selected as the other RRI; the comparison of these two RRI values was utilized to obtain a pattern signal of the gesture which was corresponding to the controlling instruction for the Music Player. Eventually, a Music Player was programmed and the pattern signal generated by gesture recognition was used to control the Music Player as willing to realize four basic functions: “play”, “pause”, “previous” and “next”. A series of tests using our gesture recognition based Music Player was conducted under the condition with different kinds of complex backgrounds, and the results showed the satisfactory performance of our interactive designing.

  12. Verbal communication of story facilitators in multi-player role-playing games

    DEFF Research Database (Denmark)

    Tychsen, Anders; Brolund, Thea; Hitchens, Michael

    2008-01-01

    Multi-player role-playing games form one of the key examples of interactive, emergent and collaborative storytelling systems available. These games and the collaborative stories that they create, are commonly facilitated by a specialized participant, the game master. In the current study, the ver...... verbal communication of game masters in a series of role-playing game sessions is categorized and analyzed depending on form and content, using protocol analysis, establishing a model for the verbal communication of game masters. © 2008 Springer Berlin Heidelberg....

  13. A Profile of Fitness Parameters and Performance of Volleyball Players

    Directory of Open Access Journals (Sweden)

    Govind B. Taware

    2013-07-01

    Full Text Available Background: Ball games require comprehen-sive ability including physical, technical, men-tal and tactical abilities. Among them, physicalabilities of players exert marked effects on theskill of the players themselves and the tacticsof the team. Therefore players must have thephysical abilities to meet the demand of thesport. Volleyball is one of the most popularlyplayed games in the world. Unfortunately, thelevel of performance of the Indian volleyballplayers lags far behind the international stan-dards. Aim of the Study: The present study wasaimed to assess flexibility, muscular endurance,power and cardio-respiratory endurance of vol-leyball players and to compare the results withage matched controls. Also, to compare thefindings of the volleyball players with that ofthe international norms from the available lit-erature and to make some suggestions for theimprovement in their performance level. Ma-terial and Methods: The study was carried outin 40 male volleyball players aged between 17to 26 years and 40 ages matched male controls.Physical fitness parameters namely flexibility,muscular endurance, power and cardio-respi-ratory endurance were measured, data was ana-lyzed using unpaired ‘t’-test. Results: It was ob-served that all physical fitness parameters weresignificantly more in players as compared totheir aged-matched controls but when values ofthe subjects were compared to internationalstandards; our subjects were behind the recom-mended norms for the elite volleyball players.Conclusion: The volleyball players have moreadvantage of flexibility muscular endurance,power and cardio-respiratory endurance.

  14. Somatotype, size and body composition of competitive female volleyball players.

    Science.gov (United States)

    Malousaris, Grigoris G; Bergeles, Nikolaos K; Barzouka, Karolina G; Bayios, Ioannis A; Nassis, George P; Koskolou, Maria D

    2008-06-01

    The aim of this study was to describe the morphological characteristics of competitive female volleyball players. For this purpose, body weight and height, breadths and girths as well as skinfold thickness at various body sites were assessed in 163 elite female volleyball players (age: 23.8+/-4.7 years, years of playing: 11.5+/-4.2, hours of training per week: 11.9+/-2.9, means+/-S.D.). Seventy-nine of these players were from the A1 division and the rest from the A2 division of the Greek National League. Two-way ANOVA was used to compare the differences in these characteristics between competition level and playing position. Body height ranged from 161cm to 194cm, and the mean value (177.1+/-6.5cm) was not inferior to that of international players of similar calibre. Adiposity of these players (sum of 5 skinfolds: 51.8+/-10.2mm, percent body fat: 23.4+/-2.8) was higher than that reported in other studies in which, however, different methodology was used. Volleyball athletes of this study were mainly balanced endomorphs (3.4-2.7-2.9). The A1 division players were taller and slightly leaner with greater fat-free mass than their A2 counterparts. Significant differences were found among athletes of different playing positions which are interpreted by their varying roles and physical demands during a volleyball game. The volleyball players who play as opposites were the only subgroup of players differing between divisions; the A2 opposites had more body fat than A1 opposites. These data could be added in the international literature related to the anthropometric characteristics of competitive female volleyball players. PMID:17697797

  15. Examining key design decisions involved in developing a serious game for child sexual abuse prevention

    OpenAIRE

    Colleen Joy Stieler-Hunt; Christian Martyn Jones; Ben eRolfe; Kay ePozzebon

    2014-01-01

    This paper presents a case study of the key decisions made in the design of Orbit, a child sexual abuse prevention computer game targeted at school students between 8 and 10 years of age. Key decisions include providing supported delivery for the target age group, featuring adults in the program, not over-sanitising game content, having a focus on building healthy self-concept of players, making the game engaging and relatable for all players and evaluating the program. This case study has im...

  16. Examining key design decisions involved in developing a serious game for child sexual abuse prevention

    OpenAIRE

    Stieler-Hunt, Colleen; Christian M. Jones; Rolfe, Ben; Pozzebon, Kay

    2014-01-01

    This paper presents a case study of the key decisions made in the design of Orbit, a child sexual abuse prevention computer game targeted at school students between 8 and 10 years of age. Key decisions include providing supported delivery for the target age group, featuring adults in the program, not over-sanitizing game content, having a focus on building healthy self-concept of players, making the game engaging and relatable for all players and evaluating the program. This case study has im...

  17. Sports players : the heroes of the mediated sacred sphere

    Directory of Open Access Journals (Sweden)

    María del Mar RUBIO-HERNÁNDEZ

    2011-01-01

    Full Text Available Broadcasted sport is one of the elements of the mediated culture which mobilizes extremely passionate masses. Thus, it can be considered as a mythical expression within current society, since contemporary era is witness to the revival of the sacred which manifests through rituals, myths and the divinization of certain products and celebrities. This article analyzes how media depictions exalt players as objects of worship and devotion. It will specifically focus on the most successful Spanish sportsmen such as the tennis player Rafael Nadal and the players of the national soccer team and how they are promoted as national heroes in advertising.

  18. EFFECT OF LEADERSHIP ON BIG FIVE FACTORS OF INTERUNIVERSITY PLAYERS

    OpenAIRE

    Quadri Syed Javeed

    2014-01-01

    Aim of the study was to investigate the effect of leadership on big five factors of interuniversity players. Hypotheses: there is no significant difference between high leadership interuniversity players than the low leadership interuniversity players with respect to big five factors. Sample:For the present study 100 Sample were belongings to Maharashtra, 50 subjects were high leadership sportsmen (M = 23.44, SD = 3.61) and 50 subjects were low leadership (M = 24.87, SD = 4.13). The age range...

  19. Dynasty discount: inter-team differentials in NHL player compensation

    OpenAIRE

    Stooke, Benoit

    2008-01-01

    In the past few years, a lot of work has been done to study the effect of firms in wage determination. In fact, firms have been found to contribute a great deal to intra-industry wage differentials. This paper converts this firm effect into a team effect using NHL player and team data and tries to find inter-team differences in NHL player compensation. Using information from various sources, an analysis of player salaries for the period 1998-2004 is done using a standard wage regression with ...

  20. Management of female handball players' activity applying interactive technologies

    Directory of Open Access Journals (Sweden)

    Frolova L.S.

    2012-04-01

    Full Text Available The efficiency of developed methods for the control of female handball players' readiness to competitive activity was determined. The opportunities of team management regarding the specification of playing role, the formation of the starting line of players and the replacement according to game priorities in attack or defense were considered. The availability of the adequate zone of handball players' mobilizing readiness that allows to have a significant influence on individual effectiveness in the conditions of optimal management and to increase the quality of team game was determined.

  1. Valuation of football players : a complete pricing framework

    OpenAIRE

    Gulbrandsen, Anders Munkhaugen; Gulbrandsen, Christian Munkhaugen

    2011-01-01

    In this thesis we will describe a football player’s value to a football club. First we will explore how a player can generate revenue. In doing so, we will describe two valuation factors, where a football player can fulfil none, one or both of them. The two factors will describe how a football player can generate revenue for his club. Next we will present a valuation model based on theory from option pricing. The valuation model will be linked up to the two factors, and give us...

  2. Radiographic knee osteoarthritis in ex-elite table tennis players

    OpenAIRE

    Rajabi Reza; Johnson Gillian M; Alizadeh Mohammad H; Meghdadi Nazanin

    2012-01-01

    Abstract Background Table tennis involves adoption of the semi-flexed knee and asymmetrical torsional trunk movements creating rotational torques on the knee joint which may predispose players to osteoarthritis (OA) of the knee. This study aims to compare radiographic signs of knee OA and associated functional levels in ex-elite male table tennis players and control subjects. Methods Study participants were 22 ex-elite male table tennis players (mean age 56.64 ± 5.17 years) with 10 years of i...

  3. Personality traits and life satisfaction among online game players.

    Science.gov (United States)

    Chen, Lily Shui-Lien; Tu, Hill Hung-Jen; Wang, Edward Shih-Tse

    2008-04-01

    The DFC Intelligence predicts worldwide online game revenues will reach $9.8 billion by 2009, making online gaming a mainstream recreational activity. Understanding online game player personality traits is therefore important. This study researches the relationship between personality traits and life satisfaction in online game players. Taipei, Taiwan, is the study location, with questionnaire surveys conducted in cyber cafe shops. Multiple regression analysis studies the causal relationship between personality traits and life satisfaction in online game players. The result shows that neuroticism has significant negative influence on life satisfaction. Both openness and conscientiousness have significant positive influence on life satisfaction. Finally, implications for leisure practice and further research are discussed. PMID:18422405

  4. Nutrition review for hockey players : enhancing performance through nutrition

    OpenAIRE

    Bursich, Chris

    2011-01-01

    With the advancement of sports medicine in the past decade, hockey players all over the world are always trying to find a competitive edge through nutritional education and proper eating. It is very common to find young junior players looking to make the jump into the professional game always trying to find ways to get bigger and add lean muscle mass, likewise, there are always players looking to drop a few pounds while keeping their muscle mass. Research has proven that through proper educat...

  5. Network Formation Game with Different Cost Value for Players

    OpenAIRE

    Govindaraj, Dinesh

    2016-01-01

    In Social Networks, it is often interesting to study type of networks formed, its efficiency with respect to social objective and which networks are stable. Many work have already been there in this area. Players in network formation game will incur some cost to form a link. In previous work, all player will have same cost for forming a link int he network. Here we will the study the optimal network and Nash equilibrium network when each player have different cost value for forming the link i...

  6. Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis

    OpenAIRE

    Eckhardt, Ines; Rösler, Stefanie; Fulda, Simone

    2013-01-01

    Smac mimetic promotes apoptosis by neutralizing inhibitor of apoptosis (IAP) proteins and is considered as a promising cancer therapeutic. Although an autocrine/paracrine tumor necrosis factor-α (TNFα) loop has been implicated in Smac mimetic-induced cell death, little is yet known about additional factors that determine sensitivity to Smac mimetic. Using genome-wide gene expression analysis, we identify death receptor 5 (DR5) as a novel key mediator of Smac mimetic-induced apoptosis. Althoug...

  7. Number of Players and Relative Pitch Area per Player: Comparing Their Influence on Heart Rate and Physical Demands in Under-12 and Under-13 Football Players.

    Science.gov (United States)

    Castellano, Julen; Puente, Asier; Echeazarra, Ibon; Usabiaga, Oidui; Casamichana, David

    2016-01-01

    The aim of the present study is to analyse the influence of different large-sided games (LSGs) on the physical and physiological variables in under-12s (U12) and -13s (U13) soccer players. The effects of the combination of different number of players per team, 7, 9, and 11 (P7, P9, and P11, respectively) with three relative pitch areas, 100, 200, and 300 m(2) (A100, A200, and A300, respectively), were analysed in this study. The variables analysed were: 1) global indicator such as total distance (TD); work:rest ratio (W:R); player-load (PL) and maximal speed (Vmax); 2) heart rate (HR) mean and time spent in different intensity zones of HR (90%), and; 3) five absolute (16 Km h(-1)) and three relative speed categories (60% Vmax). The results support the theory that a change in format (player number and pitch dimensions) affects no similarly in the two players categories. Although it can seem that U13 players are more demanded in this kind of LSG, when the work load is assessed from a relative point of view, great pitch dimensions and/or high number of player per team are involved in the training task to the U12 players. The results of this study could alert to the coaches to avoid some types of LSGs for the U12 players such as: P11 played in A100, A200 or A300, P9 played in A200 or A300 and P7 played in A300 due to that U13>U12 in several physical and physiological variables (W:R, time spent in 84-90%HRmax, distance in 8-13 and 13-16 Km h(-1) and time spent in 40-60%Vmax). These results may help youth soccer coaches to plan the progressive introduction of LSGs so that task demands are adapted to the physiological and physical development of participants. PMID:26752422

  8. APOPTOSIS IN WHOLE MOUSE OVARIES

    Science.gov (United States)

    Apoptosis in Whole Mouse Ovaries Robert M. Zucker Susan C. Jeffay and Sally D. Perreault Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, 27711.

  9. Non-invasive Player Experience Estimation from Body Motion and Game Context

    DEFF Research Database (Denmark)

    Burelli, Paolo; Triantafyllidis, George; Patras, Ioannis

    . The data collected was analysed and a neural network was trained to find the mapping between player body movements, player in- game behaviour and player experience. The results reveal that some aspects of player experience, such as anxiety or challenge, can be detected with high accuracy (up to 81...

  10. Assessments of young soccer players: a holistic approach.

    Science.gov (United States)

    Reilly, Thomas

    2006-08-01

    Use of scores on a single test of endurance which discriminates potentially talented under-age players' performance is insufficient for prediction of later performance, but such data could be useful when considered with other test scores. PMID:17037665

  11. A characterization of 2-player mechanisms for scheduling

    CERN Document Server

    Christodoulou, George; Vidali, Angelina

    2008-01-01

    We study the mechanism design problem of scheduling unrelated machines and we completely characterize the decisive truthful mechanisms for two players when the domain contains both positive and negative values. We show that the class of truthful mechanisms is very limited: A decisive truthful mechanism partitions the tasks into groups so that the tasks in each group are allocated independently of the other groups. Tasks in a group of size at least two are allocated by an affine minimizer and tasks in singleton groups by a task-independent mechanism. This characterization is about all truthful mechanisms, including those with unbounded approximation ratio. A direct consequence of this approach is that the approximation ratio of mechanisms for two players is 2, even for two tasks. In fact, it follows that for two players, VCG is the unique algorithm with optimal approximation 2. This characterization provides some support that any decisive truthful mechanism (for 3 or more players) partitions the tasks into gro...

  12. Development of speed qualities of skilled water-polo players

    Directory of Open Access Journals (Sweden)

    Ostrovsky M.V.

    2010-02-01

    Full Text Available Swimming preparation of water-polo players is the basic factor of victory of command. There are a few variants of development of speed swimming preparation. The effective pedagogical mean of stimulation of speed qualities is brief exercises at the end of employments after long aerobic work. The purpose of work is an improvement of method of speed preparation of skilled water-polo players. 26 skilled water-polo players (MS -14 and KMS - 12 took part in an experiment in age from 21 to 32 years. The results of correction of structure of training employment are in-process presented in micro cycle. They are directed on the improvement of speed qualities of water-polo players.

  13. Preferred Leadership Behaviours of Male and Female Badminton Players

    Directory of Open Access Journals (Sweden)

    Rajkumar S HARMA

    2015-06-01

    Full Text Available Pr eferences for specific coaching behaviours of male and female Badminton players were measured by the modified and revised Leadership Scale for Sport. Eighty two (Males=61, Females=21 badminton players were selected from amongst the players representing th eir respective university teams in East - zone Inter - university Badminton (Men/Women tournaments held at Bilaspur (CG. The present investigation noted the statistically significant differences among East - zone Inter - university level male as well as female B adminton player’s preferences for specific coaching behaviour. Differences were not observed between male and female badminton players in all the dimensions together of specific coaching behaviours of preferred leadership. It is recommended that coaches a lign their coaching style to meet the needs of their teams.

  14. Soccer players' fitting perception of different upper boot materials.

    Science.gov (United States)

    Olaso Melis, J C; Priego Quesada, J I; Lucas-Cuevas, A G; González García, J C; Puigcerver Palau, S

    2016-07-01

    The present study assessed the influence of upper boot materials on fitting perception. Twenty players tested three soccer boots only differing in the upper boot material (natural calf leather, natural kangaroo leather and synthetic leather). Players reported fitting perception and preference on specific foot areas using a perceived fitting scale. Ratings were averaged for every foot area. Repeated measures ANOVA was used to analyze the differences between boots. The kangaroo leather boots were perceived tighter and closer to the preferred fitting in general fitting, metatarsals area and instep area. The synthetic leather boots were perceived as the loosest and as the most distant boot from the preferred fitting in medial front area and instep area. In conclusion, the type of upper boot material influences the fitting perception of soccer players. The kangaroo leather was the material whose fitting was perceived closest to the players fitting preference. PMID:26995033

  15. Extensive monitoring through multiple blood samples in professional soccer players

    DEFF Research Database (Denmark)

    Heisterberg, Mette F; Fahrenkrug, Jan; Krustrup, Peter;

    2013-01-01

    ABSTRACT: The aim of this study was to make a comprehensive gathering of consecutive detailed blood samples from professional soccer players, and to analyze different blood parameters in relation to seasonal changes in training and match exposure.Blood samples were collected five times during a six...... months period and analyzed for 37 variables in 27 professional soccer players from the best Danish league. Additionally, players were tested for body composition, VO2max and physical performance by the Yo-Yo intermittent endurance sub-max test (IE2).Multiple variations in blood parameters occurred during...... of the season. Leucocytes decreased with increased physical training. Lymphocytes decreased at the end of the season. VO2max decreased towards the end of the season whereas no significant changes were observed in the IE2 test.The regular blood samples from elite soccer players reveal significant changes...

  16. Hypermobility and sports injuries in junior netball players

    OpenAIRE

    Smith, R.; Damodaran, A.; Swaminathan, S.; Campbell, R.; Barnsley, L

    2005-01-01

    Objective: To evaluate the incidence of hypermobility in young female netball players and to determine the relation between hypermobility, previous injuries sustained in netball or other sports, and the use of protective equipment.

  17. Hypoconnectivity and Hyperfrontality in Retired American Football Players

    Science.gov (United States)

    Hampshire, Adam; MacDonald, Alex; Owen, Adrian M.

    2013-10-01

    Recent research has raised concerns about the long-term neurological consequences of repetitive concussive and sub-concussive injuries in professional players of American Football. Despite this interest, the neural and psychological status of retired players remains unknown. Here, we evaluated the performances and brain activation patterns of retired National Football League players (NFL alumni) relative to controls using an fMRI-optimised neuropsychological test of executive function. Behaviourally, the NFL alumni showed only modest performance deficits on the executive task. By contrast, they showed pronounced hyperactivation and hypoconnectivity of the dorsolateral frontal and frontopolar cortices. Critically, abnormal frontal-lobe function was correlated with the number of times that NFL alumni reported having been removed from play after head injury and was evident in individual players. These results support the hypothesis that NFL alumni have a heightened probability of developing executive dysfunction and suggest that fMRI provides the most sensitive biomarker of the underlying neural abnormality.

  18. Clinical Measures of Shoulder Mobility in the Professional Baseball Player

    OpenAIRE

    Downar, Jacquelyn M; Sauers, Eric L.

    2005-01-01

    Context: Professional baseball players must achieve a delicate balance between shoulder mobility and stability to attain optimal sports performance. The sport-specific demands of repetitive overhead throwing may result in an altered mobility-stability relationship.

  19. Apoptosis in cancer: therapeutic implications

    OpenAIRE

    Negoescu, A.

    2000-01-01

    This review outlines the principal limitations of the mechanisms of active cell death (ACD, apoptosis) as the basis of tumorigenesis and the rationale of almost all therapies of malignancy. The concentration of cancer therapy in the directon of ACD induction is presented as both the result of progressive understanding of the mechanisms of apoptosis and that of the favourable tumor environment for ACD signal transmission. The latter property induces the by-stand...

  20. ARM 7 BASED MP3 PLAYER

    Directory of Open Access Journals (Sweden)

    Ashiq V Mehta

    2014-02-01

    Full Text Available MP3 is a patented encoding format for digital audio which uses a form of lossy data compression. It is a common audio format for consumer audio streaming or storage, as well as a de facto standard of digital audio compression for the transfer and playback of music on most digital audio players. Since the MPEG-1 Layer III encoding technology is nowadays widely used it might be interesting to gain knowledge of how this powerful compression/decompression scheme actually functions. The MPEG-1 Layer III is capable of reducing the bit rate with a factor of 12 without almost any audible degradation. Arm7 lpc2148 is arm7tdmi-s core board microcontroller that uses 16/32-bit 64 pin (lqfp microcontroller no.lpc2148 from Philips (nxp.The hardware system of lpc2148 includes the necessary devices within only one mcu has such as usb, adc, dac, timer/counter, pwm, capture, i2c, spi, uart, and etc.

  1. Stress, and Inflammation in Young Soccer Players

    Directory of Open Access Journals (Sweden)

    Ivana Baralic

    2015-01-01

    Full Text Available The physiologic stress induced by physical activity is reflected in immune system perturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx supplementation on salivary IgA (sIgA and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4 mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.

  2. Player 1 kills player 2 : representación de la violencia en el videojuego

    OpenAIRE

    Bellmunt Soler, Marc

    2012-01-01

    Un recorrido breve por la representación de la violencia en algunos de los títulos más significativos del videojuego contemporáneo, centrándose en la descorporalización de la misma, su uso como mecánica de separación de grupos de jugadores y la opción autorreflexiva de algunos videojuegos sobre el tema. A brief review of the representation of violence in some of the most relevant contemporary videogames, focusing on the decorporalization of said violence, its use as a means to separate player...

  3. On the Release of Players to National Teams

    OpenAIRE

    Oliver Guertler; Markus Lang; Tim Pawlowski

    2011-01-01

    The release of players from a club to the national team often leads to a conflict concerning the duration of the players' stay with the national team. Based on a theoretical bargaining model, we examine whether intervention in this conflict by a governing body is desirable. We show that bargaining between the club and the national team yields a socially inefficient outcome if financial compensation is either prohibited or limited. If, however, the national team is allowed to pay unlimited fin...

  4. The strategy of players on the European gas market

    International Nuclear Information System (INIS)

    One result of opening up the European gas market to competition has been to increase the number and diversity of the players involved, whether producers, suppliers or electric utilities. However, while the gas on offer is still controlled by a handful of market players given the increasing importance of state-owned companies from exporting countries outside Europe, the downstream gas sector continues to show a strong concentration of incumbent operators seeking a dominant position in the supply of gas. (author)

  5. Use of Mp3-Players as a Coping Resource

    OpenAIRE

    Marie Strand Skånland

    2011-01-01

    A crucial aspect of maintaining good mental health is to cope successfully with everyday stressors. This article explores the MP3 player as a technology of coping related to the stress of everyday life, in particular two common stressors in the urban environment: crowding and noise. The MP3 player has become a prime medium for everyday music listening, as individuals can carry a vast amount of music with them wherever they go. This unprecedented availability of music raises questions about it...

  6. Three-player quantum Kolkata restaurant problem under decoherence

    OpenAIRE

    M. Ramzan

    2011-01-01

    Effect of quantum decoherence in a three-player quantum Kolkata restaurant problem is investigated using tripartite entangled qutrit states. Amplitude damping, depolarizing, phase damping, trit-phase flip and phase flip channels are considered to analyze the behaviour of players payoffs. It is seen that Alice's payoff is heavily influenced by the amplitude damping channel as compared to the depolarizing and flipping channels. However, for higher level of decoherence, Alice's payoff is strongl...

  7. Considering Co-Players : Implications for research and design

    OpenAIRE

    Eklund, Lina

    2015-01-01

    This empirical study explores the role of co-players in players’ motivations and experiences of gaming through relational sociological analyses of interview and survey data. The aim is to bring attention to the importance of divergent gaming partners, and to offer some implications for considering co-players in game research and design. Results explore three gaming situations: playing with family members, playing with friends and playing with strangers, and shows how differently these co-play...

  8. Financial planning for retirement amongst South African professional soccer players

    OpenAIRE

    J Maseko; J. Surujlal

    2013-01-01

    Logically, financially-educated individuals should make better financial decisions for their families, increasing their economic security and well-being. The purpose of this study was to explore the financial planning and personal financial management of South African professional soccer players. In the process, a variety of issues were investigated. The research focused on the following important question: Why is financial literacy important particularly for soccer players who experience sho...

  9. EMOTIONAL INTELLIGENCE AMONG FEMALE BASEBALL PLAYERS: A PSYCHOLOGICAL PROBE

    Directory of Open Access Journals (Sweden)

    Dalwinder Singh

    2015-09-01

    Full Text Available Purpose : The present study was conducted to determine the emotional intelligence among Indian female baseball players. Material : For the purpose of present study, two hundred (N=200 senior national female baseball players were selected through purposive sampling technique from different regions of India. They were selected from four different regions: A (North region baseball players=50, B (East region baseball players=50, C (West region baseball players=50 and D (South region baseball players=50. To collect the required data for the present study, the questionnaire developed by Hyde et al. (2001 on emotional intelligence was administered. One Way Analysis of Variance (ANOVA was employed to compare the entire regions. Where ‘F’ values were found significant, LSD (Least Significant Difference Post-hoc test was applied to find out the direction and degree of difference. The level of significance was set at 0.05. Results : Significant differences were observed among North, East, West and South regions female baseball players on the sub-parameters; empathy, self-development, value orientation and on the parameter Emotional Intelligence (Total. No significant differences were noticed on the sub-parameters; self-awareness, self-motivation, emotional stability, managing relations, integrity, commitment and altruistic behaviour. Conclusion: The outcome of results might be due to the fact that East region female baseball players are able to pay attention to the worries and concerns of others, can listen to someone without the urge to say something, can stay focused under pressure, are able to handle multiple demands and able to identify and separate their emotions.

  10. Sportsmanship rating scale in tennis competition with young players

    OpenAIRE

    Gimeno Marco, Fernando; Lacambra Correas, David; Marcén Muñío, Celia; Sáenz Ibáñez, Alfredo; Castillo Salazar, Susana; Sánchez Sanz, María Elisa

    2013-01-01

    World Conference on Psychology and Sociology 2012 CC BY-NC-ND [EN] This study presents the psychometric properties of a rating scale of sportsmanship in tennis competitions with young players. A total of 446 players used this scale to asses the games they played during a season (n=223). Analyses confirmed the discriminative capacity both sportsmanship(12)and unsportsmanlike(17)items, and high internal consistency of the overall scale (Cronbach's Alpha = 0,702). Moreover, the analysi...

  11. An Analysis of Futsal Players' Self-Esteem Levels

    Science.gov (United States)

    Kocak, Mehmet

    2015-01-01

    The purpose of this study is to investigate the self-esteem levels of futsal players according to certain variables. The samples of the study constituted 119 females and 96 males; a total of 215 players with an average age of 21.57 ± 2.20 years. The research was carried out with the end of "Rosenberg self-esteem Scale" developed by…

  12. Different injury pattern in goalkeepers compared to field players

    DEFF Research Database (Denmark)

    Eirale, Cristiano; Tol, Johannes L; Whiteley, Rod;

    2014-01-01

    Goalkeepers have a specific physiological and biomechanical profile including hip loading with increased frontal plane kinetics and explosive side jumps. The aim of this study is to analyze the injury incidence in professional goalkeepers and to compare this with field players.......Goalkeepers have a specific physiological and biomechanical profile including hip loading with increased frontal plane kinetics and explosive side jumps. The aim of this study is to analyze the injury incidence in professional goalkeepers and to compare this with field players....

  13. Stress and recovery of players in Kontinental Hockey League

    OpenAIRE

    Westerlund, Tomas

    2015-01-01

    There are a lot of information about physical stress in different exercises and competition situations, but not so much research about recovery in professional team sport. The aim of this study was to produce new information about stress and recovery of the players in the international league. Another objective was to find out the individual differences of the stress and recovery of the players, when the program is the same for all. The big amount of games during the season has...

  14. The strategy of players on the European gas market

    Energy Technology Data Exchange (ETDEWEB)

    Lecarpentier, A

    2006-07-01

    One result of opening up the European gas market to competition has been to increase the number and diversity of the players involved, whether producers, suppliers or electric utilities. However, while the gas on offer is still controlled by a handful of market players given the increasing importance of state-owned companies from exporting countries outside Europe, the downstream gas sector continues to show a strong concentration of incumbent operators seeking a dominant position in the supply of gas. (author)

  15. The effects of graphical fidelity on player experience

    OpenAIRE

    Gerling, Kathrin M.; Birk, Max; Mandryk, Regan L.; Doucette, Andre

    2013-01-01

    Graphical assets in video games have become increasingly complex over the years, but little is known about their effect on player experience (PX). In this paper, we present results of a controlled study with 48 participants comparing how abstract and stylized graphics influence player experience in casual games. Our results show that high-fidelity graphics result in a more positive impression of the game. However, we also show that many effects are only present in the game with a more challen...

  16. Video Game Players Show More Precise Multisensory Temporal Processing Abilities

    OpenAIRE

    Donohue, Sarah E.; Woldorff, Marty G.; Mitroff, Stephen R.

    2010-01-01

    Recent research has demonstrated enhanced visual attention and visual perception in individuals with extensive experience playing action video games. These benefits manifest in several realms, but much remains unknown about the ways in which video game experience alters perception and cognition. The current study examined whether video game players’ benefits generalize beyond vision to multisensory processing by presenting video game players and non-video game players auditory and visual stim...

  17. Hand Grip Strength Vs. Sprint Effectiveness in Amputee Soccer Players

    OpenAIRE

    Wieczorek Marta; Wiliński Wojciech; Struzik Artur; Rokita Andrzej

    2015-01-01

    Amputee soccer is one of the types of soccer designed for the disabled, especially those who have undergone amputations, as well as those with extremity dysfunction. The objective of the study was to find the relationship between hand grip strength and sprint time in amputee soccer players. Thirteen field amputee soccer players participated in the study. A SAEHAN hydraulic hand dynamometer manufactured by Jamar was used for hand grip strength measurements. The sprint running test was conducte...

  18. DIFFERENT ENDURANCE CHARACTERISTICS OF FEMALE AND MALE GERMAN SOCCER PLAYERS

    OpenAIRE

    Baumgart, C; Hoppe, M.W.; Freiwald, J.

    2014-01-01

    The aims of the present study were to assess gender differences regarding lactate threshold and intermittent shuttle run performance in female and male soccer players as well as to investigate the relationships between both endurance characteristics in both genders. Fourteen female (1st division) and thirteen male (4th division) soccer players completed an incremental test (IT) to determine running velocities at 2 and 4 mmol · l−1 blood lactate (v2 and v4) and maximum velocity (vmax) as well ...

  19. COMPARATIVE STUDY OF ACHIEVEMENT MOTIVATION BETWEEN VOLLEYBALL AND HOCKEY PLAYERS

    OpenAIRE

    Ramesh Chand Yadav; Avadhesh Kumar

    2014-01-01

    The objective of the study was to find out the psychological differences between volleyball and hockey players in the relation to sports achievement motivation. In this study, hundred male volleyball (N=50) and hockey (N=50) players were randomly selected as the subjects for the study. The subjects selected from the state of Uttar Pradesh. The age levels of the subjects were ranged from 18 to 25 years. To assess the achievement motivation, with help of Sports Achievement Motiv...

  20. COMPETITIVE STATE ANXIETY AMONG ADOLESCENT BASKETBALL PLAYERS DURING A TOURNAMENT

    OpenAIRE

    Gururaj Puranik; Basavaraj Dammalli

    2015-01-01

    The purpose of the study was to investigate the variation in competitive state anxiety among adolescent male basketball players during a tournament. In all 113 male basketball adolescent players, who represented ten schools of Dharwad district participated in basketball tournament constituted sample for the study. Tool ‘Sports Competitive State Anxiety Inventory – II’ was administered to the participants for 20 minutes prior to their match. The inventory provided scores on state cognitive anx...

  1. Personal Branding of Elite Football Players through Social Media

    OpenAIRE

    Pyhtilä, Kaisa

    2015-01-01

    This bachelor’s thesis focuses on personal branding of professional football players in social media. Giovanni Quartana, Co-Founder of a start-up football agency TalentBox Group has commissioned this thesis. The reason for writing this thesis on personal branding for football players is because TalentBox is aiming to revamp their Marketing and Sponsorship department. This department will focus on improving football players’ personal branding by developing a unique and customized plan for ...

  2. Biomotor Structures in Elite Female Handball Players According to Performance

    OpenAIRE

    Čavala, Marijana; Rogulj, Nenad; Srhoj, Vatromir; Srhoj, Ljerka; Katić, Ratko

    2008-01-01

    In order to identify biomotor structures in elite female handball players, factor structures of morphological characteristics and basic motor abilities, and of variables evaluating situation motor abilities of elite female handball players (n=53) were determined first, followed by determination of differences and relations of the morphological, motor and specific motor space according to handball performance. Factor analysis of 16 morphological measures produced three morphologica...

  3. Ambivalent football : an ethnographic approach to postcolonial player migration

    OpenAIRE

    2008-01-01

    Abstract: This thesis is based on data stemming from fieldwork conducted during the spring of 2007, in a professional football club in Lisbon, Portugal. I am interested in how migrant players from the former colonies are included in the local football community. This thesis thus explores the inclusion and exclusion mechanisms of Portuguese football. The ethnographic approach led me to an exploration of local manifestations of global migration processes. Foreign players are making their ma...

  4. Limb circumference and performance in junior tennis players

    OpenAIRE

    Nuhmani, Shibili; Shaphe, MD Abu; Waseem, MD

    2013-01-01

    Objective: To find out the correlation of limb circumference with functional performance of junior tennis players Design: correlation design Setting: Tennis academies all over Delhi and National Capital Region Subjects: 100 junior tennis players Measurement: The limb circumferences (thigh circumference and calf circumference) of each athlete have measured and have been correlated with all the three functional performance tests. Result and conclusion: Pearson's correlation test was used to cor...

  5. Sagittal Spinal Morphology in Highly Trained Adolescent Tennis Players

    OpenAIRE

    Muyor, José M.; Estefanía Sánchez-Sánchez; David Sanz-Rivas; López-Miñarro, Pedro A.

    2013-01-01

    Sports with a predominance of forward-bending and extension postures have been associated with alterations in the sagittal spinal curvatures and greater risk of spinal injury. Because, the tennis players adopt these postures, the aims of this study were: 1) to describe spinal curvatures and pelvic tilt in male and female highly trained adolescent tennis players during relaxed standing posture and with thoracic spine corrected (in prone lying on the floor); and 2) to determine the frequency of...

  6. NUTRITIONAL DETERMINANTS OF FITNESS IN TENNIS PLAYERS IN VADODARA CITY

    OpenAIRE

    UMA IYER; NITYA ELAYATH; SWATI DHRUV; URVASHI SAREEN

    2010-01-01

    With the objective of assessing the role of nutrition and physical training on fitness in tennis players of Vadodara city, we conducted this study, employing a case-control design, wherein, 46 players from a tennis academy and 46 age and sex matched controls were studied. Socio-economic attributes, anthropometric measurements, physical fitness tests, nutrient intakes, energy expenditure, blood hemoglobin and mental well-being of the participants were evaluated using the standard protocols. BM...

  7. Differences in Energy Capacities between Tennis Players and Runners

    OpenAIRE

    Novak, Dario; Vučetić, Vlatko; Žugaj, Sanja

    2013-01-01

    The primary purpose of this study was to determine differences between elite athletes and tennis players in order to provide a clearer picture regarding the energy demands in modern tennis. Forty-eight (48) athletes and 24 tennis players from Croatian national leagues were compared in morphological and physiological parameters of an all-out incremental treadmill test with gas exchange measurements. Tennis players’ HRmax (192.96±7.75 bpm) shows values that are most different to 400-meters spri...

  8. ANTHROPOMETRIC FEATURES AND BALANCE AMONG ELITE HANDBALL PLAYERS

    OpenAIRE

    GÖKDEMİR KADIR; ÖZCAN MÜJDAT; SEVER OZAN; DEMİRHAN BILAL; ALTUNSOY MUSTAFA; GÜRKAN ALPER CENK

    2012-01-01

    Abstract Purpose: The aim of this study was to investigate the balance and body fat values of a team playing in the Turkish Handball Super League and to compare them with the international values and also to contribute the national norm to develop for the handball players. Methods: Male players from a team playing in the Turkish Handball Super League as experimental group (n=12) and university students as control group (n=12) participated in the study. The relationship among static balance, ...

  9. The Classic: Shoulder and Elbow Lesions Distinctive of Baseball Players

    OpenAIRE

    Bennett, George E.

    2012-01-01

    This Classic Article is a reprint of the original work by G. Bennett, Shoulder and Elbow Lesions Distinctive of Baseball Players. An accompanying biographical sketch of G. Bennett is available at DOI 10.1007/s11999-012-2334-3. The Classic Article is ©1947 and is reprinted with permission from Wolters Kluwer Health from Bennett G. Shoulder and elbow lesions distinctive of baseball players. Ann Surg. 1947;126:107–110.

  10. Resbuffling of the electric power industries: internationalization new players, diversification

    International Nuclear Information System (INIS)

    The changes that are being brought in the forms of organization of the power industry lead to a global restructuring of the industry. Traditional players are forced to redefine their strategies concerning vertical and horizontal integration and also diversification. They tend to internationalize their business but they are facing aggressive new-comers. The future structure of the industry is not yet determined but there will be a great number of very different corporate players. (authors). 1 fig

  11. Effect Of Plyometric Training On Explosive Power Of Basketball Players

    OpenAIRE

    P. Buvanendiran ( Jaffna); R. Barathiraj

    2013-01-01

    Abstract:The study was designed to investigate the effect of Plyometric training on explosive power of Basketball players. For this purpose of the study (N=30) thirty male Basketball players were selected from mannar district their age group of 18 to 23 as subjects and divided into two groups of fifteen subjects each as experimental group and control group following random procedure. The experimental group underwent Plyometric training over a period of nine weeks where as control group did no...

  12. A novel firefly luciferase biosensor enhances the detection of apoptosis induced by ESAT-6 family proteins of Mycobacterium tuberculosis

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Junwei; Zhang, Huan; Fang, Liurong; Xi, Yongqiang; Zhou, Yanrong; Luo, Rui; Wang, Dang, E-mail: wangdang511@126.com; Xiao, Shaobo; Chen, Huanchun

    2014-10-03

    Highlights: • We developed a novel firefly luciferase based biosensor to detect apoptosis. • The novel biosensor 233-DnaE-DEVDG was reliable, sensitive and convenient. • 233-DnaE-DEVDG faithfully indicated ESAT-6 family proteins of Mycobacterium tuberculosis induced apoptosis. • EsxA, esxT and esxL in ESAT-6 family proteins induced apoptosis. • Activation of nuclear factor-κB (NF-κB) participated in esxT-induced apoptosis. - Abstract: The activation of caspase-3 is a key surrogate marker for detecting apoptosis. To quantitate caspase-3 activity, we constructed a biosensor comprising a recombinant firefly luciferase containing a caspase-3 cleavage site. When apoptosis was induced, caspase-3 cleavage of the biosensor activated firefly luciferase by a factor greater than 25. The assay conveniently detected apoptosis in real time, indicating that it will facilitate drug discovery. We screened ESAT-6 family proteins of Mycobacterium tuberculosis and found that esxA, esxT and esxL induced apoptosis. Further, activation of nuclear factor-κB (NF-κB) and the NF-κB-regulated genes encoding tumor necrosis factor-α (TNF-α) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) participated in esxT-induced apoptosis. We conclude that this assay is useful for high-throughput screening to identify and characterize proteins and drugs that regulate apoptosis.

  13. A novel firefly luciferase biosensor enhances the detection of apoptosis induced by ESAT-6 family proteins of Mycobacterium tuberculosis

    International Nuclear Information System (INIS)

    Highlights: • We developed a novel firefly luciferase based biosensor to detect apoptosis. • The novel biosensor 233-DnaE-DEVDG was reliable, sensitive and convenient. • 233-DnaE-DEVDG faithfully indicated ESAT-6 family proteins of Mycobacterium tuberculosis induced apoptosis. • EsxA, esxT and esxL in ESAT-6 family proteins induced apoptosis. • Activation of nuclear factor-κB (NF-κB) participated in esxT-induced apoptosis. - Abstract: The activation of caspase-3 is a key surrogate marker for detecting apoptosis. To quantitate caspase-3 activity, we constructed a biosensor comprising a recombinant firefly luciferase containing a caspase-3 cleavage site. When apoptosis was induced, caspase-3 cleavage of the biosensor activated firefly luciferase by a factor greater than 25. The assay conveniently detected apoptosis in real time, indicating that it will facilitate drug discovery. We screened ESAT-6 family proteins of Mycobacterium tuberculosis and found that esxA, esxT and esxL induced apoptosis. Further, activation of nuclear factor-κB (NF-κB) and the NF-κB-regulated genes encoding tumor necrosis factor-α (TNF-α) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) participated in esxT-induced apoptosis. We conclude that this assay is useful for high-throughput screening to identify and characterize proteins and drugs that regulate apoptosis

  14. N-player quantum games in an EPR setting

    CERN Document Server

    Chappell, James M; Abbott, Derek

    2012-01-01

    The $N$-player quantum game is analyzed in the context of an Einstein-Podolsky-Rosen (EPR) experiment. In this setting, a player's strategies are not unitary transformations as in alternate quantum game-theoretic frameworks, but a classical choice between two directions along which spin or polarization measurements are made. The players' strategies thus remain identical to their strategies in the mixed-strategy version of the classical game. In the EPR setting the quantum game reduces itself to the corresponding classical game when the shared quantum state reaches zero entanglement. We find the relations for the probability distribution for $N$-qubit GHZ and W-type states, subject to general measurement directions, from which the expressions for the mixed Nash equilibrium and the payoffs are determined. Players' payoffs are then defined with linear functions so that common two-player games can be easily extended to the $N$-player case and permit analytic expressions for the Nash equilibrium. As a specific exa...

  15. Examining key design decisions involved in developing a serious game for child sexual abuse prevention

    Directory of Open Access Journals (Sweden)

    Colleen Joy Stieler-Hunt

    2014-02-01

    Full Text Available This paper presents a case study of the key decisions made in the design of Orbit, a child sexual abuse prevention computer game targeted at school students between 8 and 10 years of age. Key decisions include providing supported delivery for the target age group, featuring adults in the program, not over-sanitising game content, having a focus on building healthy self-concept of players, making the game engaging and relatable for all players and evaluating the program. This case study has implications for the design of Serious Games more generally, including that research should underpin game design decisions, game designers should consider ways of bridging the game to real life, the learning that arises from the game should go beyond rote-learning, designers should consider how the player can make the game-world their own and comprehensive evaluations of Serious Games should be undertaken.

  16. Examining key design decisions involved in developing a serious game for child sexual abuse prevention.

    Science.gov (United States)

    Stieler-Hunt, Colleen; Jones, Christian M; Rolfe, Ben; Pozzebon, Kay

    2014-01-01

    This paper presents a case study of the key decisions made in the design of Orbit, a child sexual abuse prevention computer game targeted at school students between 8 and 10 years of age. Key decisions include providing supported delivery for the target age group, featuring adults in the program, not over-sanitizing game content, having a focus on building healthy self-concept of players, making the game engaging and relatable for all players and evaluating the program. This case study has implications for the design of Serious Games more generally, including that research should underpin game design decisions, game designers should consider ways of bridging the game to real life, the learning that arises from the game should go beyond rote-learning, designers should consider how the player can make the game-world their own and comprehensive evaluations of Serious Games should be undertaken. PMID:24550880

  17. Progressive Kaizen The Key to Gaining a Global Competitive Advantage

    CERN Document Server

    Davis, John W

    2011-01-01

    All Kaizen is not one and the same. There are four distinctly different types, each with its own purpose and results. Companies that understand these differences harness Kaizen's ultimate power and influence and achieve amazing success in a global manufacturing environment. Companies must, however, restructure the major objectives of certain key players in the process and institute various management initiatives that drive Kaizen down to an individual job level. Written by recognized Lean Manufacturing professional John Davis, Progressive Kaizen: The Key to Gaining a Global Competitive Advanta

  18. Age of menarche in Indian female basketball and volleyball players at different competitive levels.

    OpenAIRE

    Mokha, R; Sidhu, L S

    1989-01-01

    Data for the age of menarche have been collected on 98 female volleyball players and 75 basketball players. The players belonged to four different levels of competition: international, national, intervarsity and district. Menarche is significantly delayed in players as compared with the controls. There is a continuous trend of increase in the age of menarche with the increasing levels of competition; menarche is more delayed in players playing at a higher level than those at the lower levels ...

  19. Group key management

    Energy Technology Data Exchange (ETDEWEB)

    Dunigan, T.; Cao, C.

    1997-08-01

    This report describes an architecture and implementation for doing group key management over a data communications network. The architecture describes a protocol for establishing a shared encryption key among an authenticated and authorized collection of network entities. Group access requires one or more authorization certificates. The implementation includes a simple public key and certificate infrastructure. Multicast is used for some of the key management messages. An application programming interface multiplexes key management and user application messages. An implementation using the new IP security protocols is postulated. The architecture is compared with other group key management proposals, and the performance and the limitations of the implementation are described.

  20. Modular Connector Keying Concept

    Science.gov (United States)

    Ishman, Scott; Dukes, Scott; Warnica, Gary; Conrad, Guy; Senigla, Steven

    2013-01-01

    For panel-mount-type connectors, keying is usually "built-in" to the connector body, necessitating different part numbers for each key arrangement. This is costly for jobs that require small quantities. This invention was driven to provide a cost savings and to reduce documentation of individual parts. The keys are removable and configurable in up to 16 combinations. Since the key parts are separate from the connector body, a common design can be used for the plug, receptacle, and key parts. The keying can then be set at the next higher assembly.

  1. Increased Apoptosis of Inflamed Odontoblasts Is Associated with CD47 Loss.

    Science.gov (United States)

    Wang, H S; Pei, F; Chen, Z; Zhang, L

    2016-06-01

    Survival of odontoblasts during infection and inflammation determines prognosis of the dental pulp. CD47 is a "self"-label surface marker on viable cells. The aim of the present study is to investigate the interaction between CD47, autophagy, and apoptosis in inflamed human dental pulp and lipopolysaccharide (LPS)-treated mDPC6T cells. We identified activation of autophagy and apoptosis in the odontoblasts due to inflammation of the human dental pulp. Furthermore, downregulation of CD47 correlated with increased autophagy and apoptosis in dental pulp of the patients afflicted with either caries and/or pulpitis. We also detected colocalization of CD47 and LC3 in the inflamed odontoblasts. In addition, functional study indicated that loss of CD47 activates autophagy and increases apoptosis, indicating that CD47 plays a key role in the LPS-induced autophagy and apoptosis of odontoblasts. PMID:26912219

  2. The effectiveness of shin guards used by football players.

    Science.gov (United States)

    Tatar, Yasar; Ramazanoglu, Nusret; Camliguney, Asiye Filiz; Saygi, Evrim Karadag; Cotuk, Hasan Birol

    2014-01-01

    In football, injuries from opponent contact occur commonly in the lower extremities. FIFA the world's governing body for football requires players to wear shin guards. The aim of this study was to compare the protective effectiveness of polypropylene based shin guards with custom-made carbon fiber ones. Three commercial polypropylene shin guards (Adidas Predator™, Adidas UCL™, and Nike Mercurial™) and two custom-made carbon fiber shin guards were examined. The experimental setup had the following parts: 1) A pendulum attached a load cell at the tip (CAS Corp., Korea) and a fixed prosthetic foot equipped with a cleat to simulate an attacker's foot. 2) An artificial tibia prepared by condensed foam and reinforced by carbon fibers protected with soft clothing. 3) A multifunctional sensor system (Tekscan Corp., F-Socket System, Turkey) to record the impact on the tibia. In the low impact force trials, only 2.79-9.63 % of the load was transmitted to the sensors. When comparing for mean force, peak force and impulse, both carbon fiber shin guards performed better than the commercial ones (Adidas Predator™, Adidas UCL™, and Nike Mercurial™) (p = 0.000). Based on these same parameters, the Nike Mercurial™ provided better protection than the Adidas Predator™ and the Adidas UCL™ (p = 0.000). In the high impact force trials, only 5.16-10.90 % of the load was transmitted to the sensors. For peak force and impulse, the carbon fiber shin guards provided better protection than all the others. Carbon fiber shin guards possess protective qualities superior to those of commercial polypropylene shin guards. Key PointsShin guards decrease the risk of serious injuries.Carbon shin guards provide sufficient protection against high impact forces.Commercially available Polypropylene based shin guards do not provide sufficient protection against high impact forces. PMID:24570615

  3. Anaerobic capacity in soccer players from different competitive levels: Comparison of players in different field positions

    Directory of Open Access Journals (Sweden)

    Vanderson Luis Moro

    2012-10-01

    Full Text Available The aim of this study was to compare anaerobic capacity in professional soccer players of different competitive levels in their respective positions in the game, early in the preseason. The study group consisted of 44 male athletes belonging to two groups (A and B of different competitive levels. Group A was composed of 20 athletes participating in the Sagres League - Portuguese. Group B was composed of 24 athletes participating in the 2nd division Championship Gaucho - Brazil. For the assessment of anaerobic capacity it was applied the Running-based Anaerobic Sprint Test - RAST. For data analysis it was used the Student t test for independent samples and analysis of variance (ANOVA One Way supplemented with post hoc Tukey. Results showed that group A athletes performed better on the average power and worst values for the fatigue index. In the group A it was found statistical difference between attacks and other two positions (midfielder and side back for the fatigue index. It is concluded that there was significant differences in anaerobic capacity, measured at the start of the preseason, evaluated soccer players who work in competitions of different levels and positions play (group A.

  4. Violent video game players and non-players differ on facial emotion recognition.

    Science.gov (United States)

    Diaz, Ruth L; Wong, Ulric; Hodgins, David C; Chiu, Carina G; Goghari, Vina M

    2016-01-01

    Violent video game playing has been associated with both positive and negative effects on cognition. We examined whether playing two or more hours of violent video games a day, compared to not playing video games, was associated with a different pattern of recognition of five facial emotions, while controlling for general perceptual and cognitive differences that might also occur. Undergraduate students were categorized as violent video game players (n = 83) or non-gamers (n = 69) and completed a facial recognition task, consisting of an emotion recognition condition and a control condition of gender recognition. Additionally, participants completed questionnaires assessing their video game and media consumption, aggression, and mood. Violent video game players recognized fearful faces both more accurately and quickly and disgusted faces less accurately than non-gamers. Desensitization to violence, constant exposure to fear and anxiety during game playing, and the habituation to unpleasant stimuli, are possible mechanisms that could explain these results. Future research should evaluate the effects of violent video game playing on emotion processing and social cognition more broadly. PMID:26299393

  5. METABOLIC DEMANDS OF MATCH PERFORMANCE IN YOUNG SOCCER PLAYERS

    Directory of Open Access Journals (Sweden)

    Alper Aslan

    2012-03-01

    Full Text Available The aim of the present study was to determine metabolic responses, movement patterns and distance covered at running speeds corresponding to fixed blood lactate concentrations (FBLs in young soccer players during a match play. A further aim of the study was to evaluate the relationships between FBLs, maximal oxygen consumption (VO2max and distance covered during a game. A multistage field test was administered to 32 players to determine FBLs and VO2max. Blood lactate (LA, heart rate (HR and rate of perceived exertion (RPE responses were obtained from 36 players during tournament matches filmed using six fixed cameras. Images were transferred to a computer, for calibration and synchronization. In all players, values for LA and HR were higher and RPE lower during the 1st half compared to the 2nd half of the matches (p < 0.01. Players in forward positions had higher LA levels than defenders, but HR and RPE values were similar between playing positions. Total distance and distance covered in jogging, low-moderate-high intensity running and low intensity sprint were higher during the 1st half (p < 0.01. In the 1st half, players also ran longer distances at FBLs [p<0.01; average running speed at 2mmol·L-1 (FBL2: 3.32 ± 0.31m·s-1 and average running speed at 4mmol·L-1 (FBL4: 3.91 ± 0.25m·s-1]. There was a significant difference between playing positions in distance covered at different running speeds (p < 0.05. However, when distance covered was expressed as FBLs, the players ran similar distances. In addition, relationships between FBLs and total distance covered were significant (r = 0.482 to 0.570; p < 0.01. In conclusion, these findings demonstrated that young soccer players experienced higher internal load during the 1st half of a game compared to the 2nd half. Furthermore, although movement patterns of players differed between playing positions, all players experienced a similar physiological stress throughout the game. Finally, total

  6. Biometry, the safe key

    OpenAIRE

    María Fraile-Hurtado; Miguel Herrero-Langreo; Pilar Menéndez-Miguel; Valerio Delgado-Villanueva

    2010-01-01

    Biometry is the next step in authentication, why do not we take this stepforward in our communication security systems? Keys are the main disadvantage in the cryptography, what if we were our own key?

  7. Key Management Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Provides a secure environment to research and develop advanced electronic key management and networked key distribution technologies for the Navy and DoD....

  8. Financial Key Ratios

    OpenAIRE

    Tănase Alin-Eliodor

    2014-01-01

    This article focuses on computing techniques starting from trial balance data regarding financial key ratios. There are presented activity, liquidity, solvency and profitability financial key ratios. It is presented a computing methodology in three steps based on a trial balance.

  9. Public Key Cryptography.

    Science.gov (United States)

    Tapson, Frank

    1996-01-01

    Describes public key cryptography, also known as RSA, which is a system using two keys, one used to put a message into cipher and another used to decipher the message. Presents examples using small prime numbers. (MKR)

  10. Megabits secure key rate quantum key distribution

    International Nuclear Information System (INIS)

    Quantum cryptography can provide unconditional secure communication between two authorized parties based on the basic principles of quantum mechanics. However, imperfect practical conditions limit its transmission distance and communication speed. Here, we implemented the differential phase shift (DPS) quantum key distribution (QKD) with an up-conversion-assisted hybrid photon detector (HPD) and achieved a 1.3 Mbits per second secure key rate over a 10 km fiber, which is tolerant against photon number splitting (PNS) attack, general collective attacks on individual photons and any other known sequential unambiguous state discrimination (USD) attacks.

  11. Mechanisms for triceps surae injury in high performance front row rugby union players: a kinematic analysis of scrummaging drills.

    Science.gov (United States)

    Flavell, Carol A; Sayers, Mark G L; Gordon, Susan J; Lee, James B

    2013-01-01

    The front row of a rugby union scrum consists of three players. The loose head prop, hooker and tight head prop. The objective of this study was to determine if known biomechanical risk factors for triceps surae muscle injury are exhibited in the lower limb of front row players during contested scrummaging. Eleven high performance front row rugby union players were landmarked bilaterally at the posterior superior iliac spine (PSIS), greater trochanter, lateral femoral epicondyle, midline of the calcaneus above the plantar aspect of the heel, midline lower leg 5cm and 20cm proximal to the lateral malleolus, at the axis of subtalar joint, lateral malleolus, and head of the fifth metatarsal. Players were video recorded during a series of 2 on 1 live scrummaging drills. Biomechanical three dimensional analysis identified large angular displacements, and increased peak velocities and accelerations at the ankle joint during attacking scrummaging drill techniques when in the stance phase of gait. This places the triceps surae as increased risk of injury and provides valuable information for training staff regarding injury prevention and scrum training practices for front row players. Key pointsFront rowers exhibited patterns of single leg weight bearing, in a position of greater ankle plantar flexion and knee extension at toe off during scrummaging, which is a risk position for TS injury.Front rowers also exhibited greater acceleration at the ankle, knee, and hip joints, and greater changes in ankle ROM from toe strike to toe off during attacking scrum drills.These reported accelerations and joint displacements may be risk factors for TS injury, as the ankle is accelerating into plantar flexion at final push off and the muscle is shortening from an elongated state. PMID:24149740

  12. Isolation of key retinoid signalling and metabolic modules in invertebrates

    Directory of Open Access Journals (Sweden)

    Ana André

    2014-05-01

    Full Text Available Retinoids are a class of molecules related to vitamin A (Retinol that are required for regulation of critical chordate ndocrine-mediated process, such as embryonic development, reproduction, and vision. To maintain such physiological process, chordates have a complex mechanism to regulate the spatial and temporal distribution of retinoids that includes metabolic and signalling modules. Initially, retinoid modules were seen as a chordate novelty. However, emerging biochemical and genomic evidences have challenged this view, clearly pointing to a more basal ancestry than previously thought. However, for the majority of non-chordate invertebrate lineages a clearly characterization of the main enzymatic/molecular players is still missing. Despite limited, the available evidence supports the presence of biologically active retinoid pathways in invertebrates. In order to enhance our insights on retinoid biology, evolution, and its putative disruption by environmental chemicals, the isolation and functional characterization of key retinoid metabolic players in marine invertebrates has been carried out.

  13. Prevalent morphometric vertebral fractures in professional male rugby players.

    Directory of Open Access Journals (Sweden)

    Karen Hind

    Full Text Available There is an ongoing concern about the risk of injury to the spine in professional rugby players. The objective of this study was to investigate the prevalence of vertebral fracture using vertebral fracture assessment (VFA dual energy X-ray absorptiometry (DXA imaging in professional male rugby players. Ninety five professional rugby league (n = 52 and union (n = 43 players (n = 95; age 25.9 (SD 4.3 years; BMI: 29.5 (SD 2.9 kg.m2 participated in the research. Each participant received one VFA, and one total body and lumbar spine DXA scan (GE Lunar iDXA. One hundred and twenty vertebral fractures were identified in over half of the sample by VFA. Seventy four were graded mild (grade 1, 40 moderate (grade 2 and 6 severe (grade 3. Multiple vertebral fractures (≥2 were found in 37 players (39%. There were no differences in prevalence between codes, or between forwards and backs (both 1.2 v 1.4; p>0.05. The most common sites of fracture were T8 (n = 23, T9 (n = 18 and T10 (n = 21. The mean (SD lumbar spine bone mineral density Z-score was 2.7 (1.3 indicating high player bone mass in comparison with age- and sex-matched norms. We observed a high number of vertebral fractures using DXA VFA in professional rugby players of both codes. The incidence, aetiology and consequences of vertebral fractures in professional rugby players are unclear, and warrant timely, prospective investigation.

  14. N-Player Quantum Games in an EPR Setting

    Science.gov (United States)

    Chappell, James M.; Iqbal, Azhar; Abbott, Derek

    2012-01-01

    The -player quantum games are analyzed that use an Einstein-Podolsky-Rosen (EPR) experiment, as the underlying physical setup. In this setup, a player’s strategies are not unitary transformations as in alternate quantum game-theoretic frameworks, but a classical choice between two directions along which spin or polarization measurements are made. The players’ strategies thus remain identical to their strategies in the mixed-strategy version of the classical game. In the EPR setting the quantum game reduces itself to the corresponding classical game when the shared quantum state reaches zero entanglement. We find the relations for the probability distribution for -qubit GHZ and W-type states, subject to general measurement directions, from which the expressions for the players’ payoffs and mixed Nash equilibrium are determined. Players’ payoff matrices are then defined using linear functions so that common two-player games can be easily extended to the -player case and permit analytic expressions for the Nash equilibrium. As a specific example, we solve the Prisoners’ Dilemma game for general . We find a new property for the game that for an even number of players the payoffs at the Nash equilibrium are equal, whereas for an odd number of players the cooperating players receive higher payoffs. By dispensing with the standard unitary transformations on state vectors in Hilbert space and using instead rotors and multivectors, based on Clifford’s geometric algebra (GA), it is shown how the N-player case becomes tractable. The new mathematical approach presented here has wide implications in the areas of quantum information and quantum complexity, as it opens up a powerful way to tractably analyze N-partite qubit interactions. PMID:22606258

  15. The Key Lake project

    International Nuclear Information System (INIS)

    Key Lake is located in the Athabasca sand stone basin, 640 kilometers north of Saskatoon, Saskatchewan, Canada. The three sources of ore at Key Lake contain 70 100 tonnes of uranium. Features of the Key Lake Project were described under the key headings: work force, mining, mill process, tailings storage, permanent camp, environmental features, worker health and safety, and economic benefits. Appendices covering the historical background, construction projects, comparisons of western world mines, mining statistics, Northern Saskatchewan surface lease, and Key Lake development and regulatory agencies were included

  16. Apoptosis in developmental and repair-related human tooth remodeling: a view from the inside

    OpenAIRE

    Mitsiadis, T. A.; De Bari, C; About, I

    2008-01-01

    Apoptosis is a key phenomenon in the regulation of the life span of odontoblasts, which are responsible for dentin matrix production of the teeth. The mechanism controlling odontoblasts loss in developing, normal, and injured human teeth is largely unknown. A possible correlation between apoptosis and dental pulp volume reduction was examined. Histomorphometric analysis was performed on intact 10 to 14 year-old premolars to follow dentin deposition and evaluate the total number of odontoblast...

  17. Game usability advancing the player experience

    CERN Document Server

    Isbister, Katherine

    2008-01-01

    I. What is usability and why should I care?A. Overview chapter Isbister and Schaffer (Editors)Introduces key concepts and positions book for primary audiences: game developers andstudents aspiring to work in game development. Addresses key concerns that developersmay have about adopting usability, and sets a broad road map of what is to come in thebook.B. Interview with Tobi Saulnier of 1st PlayableA discussion with the CEO of a small game studio about why and how she uses usabilitytechniques in her development.C. Interview with Don Norman of Nielsen Norman groupA discussion with one of the pr

  18. Iliopsoas and gluteal muscles are asymmetric in tennis players but not in soccer players.

    Directory of Open Access Journals (Sweden)

    Joaquin Sanchis-Moysi

    Full Text Available PURPOSE: To determine the volume and degree of asymmetry of iliopsoas (IL and gluteal muscles (GL in tennis and soccer players. METHODS: IL and GL volumes were determined using magnetic resonance imaging (MRI in male professional tennis (TP and soccer players (SP, and in non-active control subjects (CG (n = 8, 15 and 6, respectively. RESULTS: The dominant and non-dominant IL were hypertrophied in TP (24 and 36%, respectively, P<0.05 and SP (32 and 35%, respectively, P<0.05. In TP the asymmetric hypertrophy of IL (13% greater volume in the non-dominant than in the dominant IL, P<0.01 reversed the side-to-side relationship observed in CG (4% greater volume in the dominant than in the contralateral IL, P<0.01, whilst soccer players had similar volumes in both sides (P = 0.87. The degree of side-to-side asymmetry decreased linearly from the first lumbar disc to the pubic symphysis in TP (r = -0.97, P<0.001, SP (r = -0.85, P<0.01 and CG (r = -0.76, P<0.05. The slope of the relationship was lower in SP due to a greater hypertrophy of the proximal segments of the dominant IL. Soccer and CG had similar GL volumes in both sides (P = 0.11 and P = 0.19, for the dominant and contralateral GL, respectively. GL was asymmetrically hypertrophied in TP. The non-dominant GL volume was 20% greater in TP than in CG (P<0.05, whilst TP and CG had similar dominant GL volumes (P = 0.14. CONCLUSIONS: Tennis elicits an asymmetric hypertrophy of IL and reverses the normal dominant-to-non-dominant balance observed in non-active controls, while soccer is associated to a symmetric hypertrophy of IL. Gluteal muscles are asymmetrically hypertrophied in TP, while SP display a similar size to that observed in controls. It remains to be determined whether the different patterns of IL and GL hypertrophy may influence the risk of injury.

  19. LOCKS AND KEYS SERVICE

    CERN Multimedia

    Locks and Keys Service

    2002-01-01

    The Locks and Keys service (ST/FM) will move from building 55 to building 570 from the 2nd August to the 9th August 2002 included. During this period the service will be closed. Only in case of extreme urgency please call the 164550. Starting from Monday, 12th August, the Locks and Keys Service will continue to follow the activities related to office keys (keys and locks) and will provide the keys for furniture. The service is open from 8h30 to 12h00 and from 13h00 to 17h30. We remind you that your divisional correspondents can help you in the execution of the procedures. We thank you for your comprehension and we remain at your service to help you in solving all the matters related to keys for offices and furniture. Locks and Keys Service - ST Division - FM Group

  20. THE EVALUATION OF SOME PHYSICAL AND PHYSIOLOGICAL CAHARACTERISTICS OF TURKISH AND FOREIGN NATIONAL BADMINTON TEAM PLAYERS

    Directory of Open Access Journals (Sweden)

    Serkan REVAN

    2007-12-01

    Full Text Available The aim of this study was to evaluate of some physical and physiological characteristics of Turkish and Foreign National Badminton Team Players.The study was participated by 50 players from Turkish team (12 males and 11 females, from foreign team (13 females and 14 males. Body mass index, audio and visual reaction times, anaerobic power, body fat percentage and somatotype components of the participants were determined.While visual right hand reaction times of Turkish Male Badminton Players were better than foreign players, other physical parameters were not found as statistically significant between male player groups. While visual left hand reaction times of Turkish Female Badminton Players were better and mesomorphy values were less than foreign players, in other physical parameters a statistically significant difference could not found between female player groups.As a result, physical and physiological characteristics of Turkish and foreign badminton players were similar.

  1. Design of Emergent and Adaptive Virtual Players in a War RTS Game

    CERN Document Server

    Gutiérrez, José A García; Fernández-Leiva, Antonio J

    2012-01-01

    Basically, in (one-player) war Real Time Strategy (wRTS) games a human player controls, in real time, an army consisting of a number of soldiers and her aim is to destroy the opponent's assets where the opponent is a virtual (i.e., non-human player controlled) player that usually consists of a pre-programmed decision-making script. These scripts have usually associated some well-known problems (e.g., predictability, non-rationality, repetitive behaviors, and sensation of artificial stupidity among others). This paper describes a method for the automatic generation of virtual players that adapt to the player skills; this is done by building initially a model of the player behavior in real time during the game, and further evolving the virtual player via this model in-between two games. The paper also shows preliminary results obtained on a one player wRTS game constructed specifically for experimentation.

  2. Metal-induced apoptosis: mechanisms

    International Nuclear Information System (INIS)

    The past decade has seen an intense focus on mechanisms of apoptosis. Many important observations on the various signaling pathways mediating apoptotic cell death have been made and our understanding of the importance of apoptosis in both normal growth and development and pathophysiology has greatly increased. In addition, mechanisms of metal-induced toxicity continue to be of interest given the ubiquitous nature of these contaminants. The purpose of this review is to summarize our current understanding of the apoptotic pathways that are initiated by metals, mainly established (arsenic, cadmium, chromium, nickel, beryllium) and possible (lead, antimony, cobalt) human carcinogens. Increased understanding of metal-induced apoptosis is critical to illuminate mechanisms of metal-induced carcinogenesis, as well as the potential of metal species (arsenic) as chemotherapeutic agents

  3. A Discrete Evolutionary Model for Chess Players' Ratings

    CERN Document Server

    Fenner, Trevor; Loizou, George

    2011-01-01

    The Elo system for rating chess players, also used in other games and sports, was adopted by the World Chess Federation over four decades ago. Although not without controversy, it is accepted as generally reliable and provides a method for assessing players' strengths and ranking them in official tournaments. It is generally accepted that the distribution of players' rating data is approximately normal but, to date, no stochastic model of how the distribution might have arisen has been proposed. We propose such an evolutionary stochastic model, which models the arrival of players into the rating pool, the games they play against each other, and how the results of these games affect their ratings. Using a continuous approximation to the discrete model, we derive the distribution for players' ratings at time $t$ as a normal distribution, where the variance increases in time as a logarithmic function of $t$. We validate the model using published rating data from 2007 to 2010, showing that the parameters obtained...

  4. The movement characteristics of English Premiership rugby union players.

    Science.gov (United States)

    Cahill, Nicola; Lamb, Kevin; Worsfold, Paul; Headey, Roy; Murray, Stafford

    2013-01-01

    The purpose of this investigation was to quantify the movement characteristics of elite rugby union players during competitive play and identify whether position-related differences exist. Ninety-eight elite players from eight English Premiership Clubs were tracked using global positioning systems (GPS) during 44 competitive matches throughout the 2010/2011 season. Player positions were defined as: (1) backs or forwards; (2) front, second and back rows, scrum half, inside and outside backs; (3) 15 individual positions (numbers 1-15). Analysis revealed the game is predominantly played at low speeds with little distance covered 'sprinting' by either the backs (50 ± 76 m) or the forwards (37 ± 64 m). The backs travelled greater (P scrum half covered the greatest total distance during a match (7098 ± 778 m) and the front row the least (5158 ± 200 m). The back row covered the greatest distances at 'sprinting' speeds, particularly the number 8 position (77 m). These findings reflect notable differences in the movement characteristics displayed by elite rugby union players in specific positional roles, and reinforce the contemporary view that training programmes for such players ought to be structured with this in mind. PMID:23009129

  5. Anthropometric and performance comparisons in professional baseball players.

    Science.gov (United States)

    Hoffman, Jay R; Vazquez, Jose; Pichardo, Napoleon; Tenenbaum, Gershon

    2009-11-01

    This study compared anthropometric and performance variables in professional baseball players and examined the relationship between these variables and baseball-specific performance (i.e., home runs, total bases, slugging percentage, and stolen bases). During a 2-year period, 343 professional baseball players were assessed for height, weight, body composition, grip strength, vertical jump power, 10-yard sprint speed, and agility. Subject population consisted of players on the rosters of one of the minor league affiliates (Rookie, A, AA, AAA) or major league team (MLB). All testing occurred at the beginning of spring training. Players in Rookie and A were significantly (p baseball-specific power performance. Anthropometric measures failed to add any additional explanation to the variance in these baseball-specific performance variables. Results indicated that both anthropometric and performance variables differed between players of different levels of competition in professional baseball. Agility, speed, and lower-body power appeared to provide the greatest predictive power of baseball-specific performance. PMID:19826310

  6. Player guild dynamics and evolution in massively multiplayer online games.

    Science.gov (United States)

    Chen, Chien-Hsun; Sun, Chuen-Tsai; Hsieh, Jilung

    2008-06-01

    In the latest versions of massively multiplayer online games (MMOGs), developers have purposefully made guilds part of game environments. Guilds represent a powerful method for giving players a sense of online community, but there is little quantitative data on guild dynamics. To address this topic, we took advantage of a feature found in one of today's most popular MMOGs (World of Warcraft) to collect in-game data: user interfaces that players can modify and refine. In addition to collecting data on in-game player activities, we used this feature to observe and investigate how players join and leave guilds. Data were analyzed for the purpose of identifying factors that propel game-world guild dynamics and evolution. After collecting data for 641,805 avatars on 62 Taiwanese World of Warcraft game servers between February 10 and April 10, 2006, we created five guild type categories (small, large, elite, newbie, and unstable) that have different meanings in terms of in-game group dynamics. By viewing players as the most important resource affecting guild life cycles, it is possible to analyze game worlds as ecosystems consisting of evolving guilds and to study how guild life cycles reflect game world characteristics. PMID:18537499

  7. Etiology and Biomechanics of Tarsometatarsal Injuries in Professional Football Players

    Science.gov (United States)

    Kent, Richard W.; Lievers, W. Brent; Riley, Patrick O.; Frimenko, Rebecca E.; Crandall, Jeff R.

    2014-01-01

    Background: Tarsometatarsal (TMT) dislocations are uncommon yet debilitating athletic injuries, particularly in American football. To date, the mechanisms of athletic TMT dislocation have been described only anecdotally. This lack of information confounds the development of preventative countermeasures. Purpose: To use video analysis to provide direct, independent identification of the etiologic and mechanistic variables responsible for TMT dislocations in professional football players. Study Design: Case series; Level of evidence, 4. Methods: Sixteen professional National Football League players who sustained publicly reported TMT dislocations were identified. Publicly broadcast game footage of the plays in which injury occurred was reviewed by a panel of 5 biomechanists. Consensus was reached regarding the details surrounding injury, and a weighting was assigned to each detail based on the panel’s confidence. Results: Roughly 90% of injuries occurred while the injured player was engaged with or by another player, a detail that has heretofore been undocumented. Few injuries resulted from direct loading of either the foot or the ipsilateral limb; however, the injured foot was frequently subjected to axial loading from ground engagement with the foot in plantar flexion and the toes dorsiflexed. Injurious loading was often due to external rotation of the midfoot (86%). Fifteen of 16 injuries were season ending. Conclusion: TMT dislocations are frequently associated with engagement by or with a second player but infrequently caused by a direct blow to the foot. Axial loading of the foot, external rotation, and pronation/supination are the most common conditions during injurious loading. PMID:26535306

  8. Fitness Profiles of Elite Portuguese Rugby Union Players

    Directory of Open Access Journals (Sweden)

    Vaz Luís

    2014-07-01

    Full Text Available The aim of this study was to describe the fitness profiles of senior elite Portuguese rugby players. Forty-six senior Portuguese rugby players, classified as backs (n=22; age 26.2±2.8 and forwards (n=24; age 26.7±2.9 were assessed during physical testing sessions carried out for the Portuguese National rugby team. The body composition, maximum strength and anaerobic capacity of players are hypothesized to be important physical characteristics as successful performance in rugby is predicated on the ability to undertake skilled behaviours both quickly and whilst withstanding large forces when in contact situations. No absolute differences were found between the backs and forwards for the speed performance variables although positional differences were found across all speeds when assessed relative to body mass since the forwards were significantly heavier. Coaches and the management team can use this information for monitoring progressive improvements in the physiological capacities of rugby players. These physical characteristics of elite rugby players provide normative profiles for specific positions and should form the basis of developmental programmes for adolescents.

  9. Neural underpinnings of superior action prediction abilities in soccer players.

    Science.gov (United States)

    Makris, Stergios; Urgesi, Cosimo

    2015-03-01

    The ability to form anticipatory representations of ongoing actions is crucial for effective interactions in dynamic environments. In sports, elite athletes exhibit greater ability than novices in predicting other players' actions, mainly based on reading their body kinematics. This superior perceptual ability has been associated with a modulation of visual and motor areas by visual and motor expertise. Here, we investigated the causative role of visual and motor action representations in experts' ability to predict the outcome of soccer actions. We asked expert soccer players (outfield players and goalkeepers) and novices to predict the direction of the ball after perceiving the initial phases of penalty kicks that contained or not incongruent body kinematics. During the task, we applied repetitive transcranial magnetic stimulation (rTMS) over the superior temporal sulcus (STS) and the dorsal premotor cortex (PMd). Results showed that STS-rTMS disrupted performance in both experts and novices, especially in those with greater visual expertise (i.e. goalkeepers). Conversely, PMd-rTMS impaired performance only in expert players (i.e. outfield players and goalkeepers), who exhibit strong motor expertise into facing domain-specific actions in soccer games. These results provide causative evidence of the complimentary functional role of visual and motor action representations in experts' action prediction. PMID:24771282

  10. Different endurance characteristics of female and male german soccer players.

    Science.gov (United States)

    Baumgart, C; Hoppe, M W; Freiwald, J

    2014-08-01

    The aims of the present study were to assess gender differences regarding lactate threshold and intermittent shuttle run performance in female and male soccer players as well as to investigate the relationships between both endurance characteristics in both genders. Fourteen female (1(st) division) and thirteen male (4(th) division) soccer players completed an incremental test (IT) to determine running velocities at 2 and 4 mmol · l(-1) blood lactate (v2 and v4) and maximum velocity (vmax) as well as an interval shuttle run test (ISRT) to determine running distance. Based on v2 and v4 and their percentages in relation to vmax, three intensity zones were calculated: a low lactate zone (v4). Female soccer players have a lower v4 (8.2%), vmax (11.3%) and ISRT distance (31.6%). No gender difference was found in v2. In contrast to males, ISRT distance correlates with vmax as well as with v2 and v4 in female soccer players. The intensity zones v4 differ between genders. The present study revealed that gender differences increase when the running performance is intermittent including change of directions. In both genders, different relationships between lactate threshold and intermittent shuttle run performance exist. During incremental testing, the running performances of female and male players reflect different distributions of aerobic and anaerobic metabolic pathways. The revealed gender differences should be considered for soccer endurance training. PMID:25177102

  11. Evaluating the heading in professional soccer players by playing positions.

    Science.gov (United States)

    Erkmen, Nurtekin

    2009-09-01

    The aim of this study is to evaluate the accuracy and coordination of heading in professional soccer players of different positions. A total of 243 professional soccer players were examined for the study. The Federation Internationale de Football Association Medical Assessment and Research Center (F-MARC) test battery was used to evaluate heading in soccer players. In the heading of the ball thrown from middle of the goal, forwards were better than goalkeepers (p < 0.05). There was not a significant statistical difference between defenders, midfielders, and forwards. In the heading of the ball thrown from the right side of the goalpost, defenders were better than goalkeepers (p < 0.05) and forwards were better than goalkeepers, defenders, and midfielders (p < 0.05). In conclusion, the reason for the heading of goalkeepers being worse than the others; goalkeepers use their hands in both training and matches, whereas for forwards and defensive players being better than goalkeepers depends mainly on their positions in soccer. Trainers and coaches should give place specific training programs to improve heading ability in the training schedule of soccer players at a professional level. PMID:19675491

  12. Ιnjuries in greek amateur soccer players

    Directory of Open Access Journals (Sweden)

    GEORGIOS TSIGANOS

    2007-01-01

    Full Text Available The purpose of this study was to record retrospectivelythe epidemiology of injuries in amateur Greek soccer players. Three hundred and one (301 amateur soccer playersvoluntarily participated in the study. Participants answered aspecially-designed questionnaire that included questionsabout demographics, playing surface, division, position,hours of training plus participation, the use of stretching orprophylactic tape, the injury mechanism, the location andtype of injury. During the five years these soccer playerssustained a total of 1.745 injuries, that diagnosed by the orthopedist of the team. Most of injuries were strains (33%,overuse (27% and sprains (25%. The location of injurieswas the thigh (38 %, ankle (27% and knee (13%. Therewas a significant difference in the total number of injuriesamong soccer players with or without scoliosis (t=3.152,p. 0.05 and players that played on sand/dirt (gravel, whosustained more injuries than the players who played on artificial grass or on grass (t=3.413, p. 0.05. No differenceswere found in the other measurement parameters. The results of our study shows that spine deformities and groundsurfaces are the factors that causes more injuries in amateurGreek soccer players.

  13. Intelligent card access keys

    International Nuclear Information System (INIS)

    A newly developed access control technology allows information about users to be stored on key-like EEPROM devices. The keys store encrypted information about the user and his or her authorized access activity. Specially developed key readers scan, decrypt, and process the key data, and make the decision whether entry should be granted or denied. The key readers can function as complete, stand-alone facility management systems, incorporating access control, security monitoring, and remote control. In this configuration, the key readers provide anti-passback protection and other special features without requiring any data lines between readers. The key readers also feature sophisticated algorithmic processing for performing complex operations such as two-man control or cross zoned security annunciation. Key readers can also be interconnected with an MCM-1000 Multiples Monitoring System to form a distributed processing local area network. In such a configuration, changes in key reader status can be uploaded to the MCM-1000, and programming changes and operator commands can be downloaded to the key readers

  14. Monitoring apoptosis in real time.

    Science.gov (United States)

    Green, Allan M; Steinmetz, Neil D

    2002-01-01

    Many therapeutically active anticancer treatments exert their effect by the induction of apoptosis and necrosis. Serial biopsies in breast cancer patients have suggested that response to therapy correlates with early posttreatment increases in tumor apoptotic index. Radiolabeled technetium Tc 99m-recombinant human (rh) annexin V provides a noninvasive technique for imaging treatment-induced cell death. Annexin V is a naturally occurring human protein that binds avidly to membrane-associated phosphatidylserine (PS). PS is normally found only on the inner leaflet of the cell membrane double layer, but it is actively transported to the outer layer as an early event in apoptosis and becomes available for annexin binding. Annexin also gains access to PS as a result of the membrane fragmentation associated with necrosis. In vitro studies of apoptosis using fluorescein annexin have shown good correlation with assessments of apoptosis documented by nuclear DNA degradation and caspase activation. In vivo localization of intravenously administered Tc 99m-annexin V has been demonstrated in numerous preclinical models of apoptosis, including anti-Fas-mediated hepatic apoptosis, rejection of allogeneic heterotopic cardiac allografts, cyclophosphamide treatment of murine lymphoma, cyclophosphamide-induced apoptosis in bone marrow, and leukocyte apoptosis associated with abscess formation. Scintigraphic studies in humans using Tc 99m-rh annexin V have demonstrated the feasibility of imaging cell death in acute myocardial infarction, in tumors with a high apoptotic index, and in response to anti-tumor chemotherapy of non-small cell lung cancer, small-cell lung cancer, breast cancer, lymphoma, and sarcoma. Increased localization of Tc 99m-rh annexin V within 1 to 3 days of chemotherapy has been noted in some, but not all, subjects with these tumors. To date, most subjects showing increased Tc 99m-rh annexin V uptake after the first course of chemotherapy have shown objective

  15. Cardiomyocytic apoptosis and heart failure

    Institute of Scientific and Technical Information of China (English)

    Quanzhou Feng

    2008-01-01

    Heart failure is a major disease seriously threatening human health.Once left ventricular dysfunction develops,cardiac function usually deteriorates and progresses to congestive heart failure in several months or years even if no factors which accelerate the deterioration repeatedly exist.Mechanism through which cardiac function continually deteriorates is still unclear.Cardiomyocytic apoptosis can occur in acute stage of ischemic heart diseases and the compensated stage of cardiac dysfunction.In this review,we summarize recent advances in understanding the role of cardiomyocytic apoptosis in heart failure.

  16. Kinematics of Shooting in High School and Collegiate Lacrosse Players With and Without Low Back Pain

    Science.gov (United States)

    Wasser, Joseph G.; Chen, Cong; Vincent, Heather K.

    2016-01-01

    Background: Low back pain (LBP) and motion alterations can occur in athletes who engage in high-speed throwing motions. The relationship between LBP and shooting motion in lacrosse players is not yet known. Purpose: To quantify the effects of LBP on key kinematic parameters of the lacrosse shot and determine the contribution of the severity of LBP on specific kinematic parameters of the shooting motion. Study Design: Controlled laboratory study. Methods: High school and collegiate players (N = 24) were stratified into 2 groups based on back pain symptoms (LBP or no pain). Three-dimensional motion capture of overhead throws was used to collect data on knee, pelvis, trunk, and shoulder kinematics as well as crosse stick (the stick capped with a strung net) and ball speed. Results: Mean low back numeric pain rating scale (NRSpain) score was 2.9. Knee flexion at ball release was greater in the LBP than no pain group, indicating a more bent knee (P = .04). The LBP group demonstrated less angular velocity transfer from pelvis to trunk than the no pain group (P = .05). Total range of motion of the pelvis and shoulders during the shot and follow-through were less in the LBP group than the no pain group (83.6° ± 24.5° vs 75.9° ± 24.5°, P = .05). Age- and sex-adjusted regression analyses revealed that the low back NRSpain rating contributed 6.3% to 25.0% of the variance to the models of shoulder transverse rotation range of motion, trunk and shoulder rotation angular velocities, and knee flexion angle (P injuries. Clinical Relevance: This research identified a prehabilitation need in the understudied lacrosse population. Therapeutic strategies can be developed to strengthen the throwing motion, which could control mechanical loading patterns on the low back and minimize pain symptoms in players with chronic LBP.

  17. The Homomorphic Key Agreement

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    There are various challenges that are faced in group communication, so it is necessary to ensure session key. Key agreement is the fundamental cryptographic primitive for establishing a secure communication. It is a process of computing a shared secret contributed by two or more entities such that no single node can predetermine the resulting value. An authenticated key agreement is attained by combining the key agreement protocol with digital signatures. After a brief introduction to existing key agreement in group communication, Making use of the additive-multiplicative homomorphism in the integer ring defined by Sander and Tschudin: A new protocols, called the homomorphism key agreement, was designed, which can be self-contributory, robust, scalable and applicable in group communication.

  18. ANALYSIS OF SELECTION INDICATORS OF BADMINTON PLAYERS BY THE DELPHI METHOD AND ANALYTIC HIERARCHY PROCESS

    Directory of Open Access Journals (Sweden)

    Han-Chen Huang

    2015-02-01

    Full Text Available This study aims to clarify the selection standard of potential badminton players and construct an evaluation model of badminton players. Through literature review and the Delphi Method, this study validated the selection indicators of badminton team players: body type, physical qualities, physical functions, psychological qualities, and intelligence level, including a total of 17 detailed indicators. The researcher then interviewed badminton coaches and applied Analytic Hierarchy process (AHP to determine the importance of the indicators of potential badminton players for badminton coaches. A selection model of badminton players was constructed. The results can serve as reference for badminton coaches’ scientific and objective selection of players.

  19. Decentralized Restless Bandit with Multiple Players and Unknown Dynamics

    CERN Document Server

    Liu, Haoyang; Zhao, Qing

    2011-01-01

    We consider decentralized restless multi-armed bandit problems with unknown dynamics and multiple players. The reward state of each arm transits according to an unknown Markovian rule when it is played and evolves according to an arbitrary unknown random process when it is passive. Players activating the same arm at the same time collide and suffer from reward loss. The objective is to maximize the long-term reward by designing a decentralized arm selection policy to address unknown reward models and collisions among players. A decentralized policy is constructed that achieves a regret with logarithmic order when an arbitrary nontrivial bound on certain system parameters is known. When no knowledge about the system is available, we extend the policy to achieve a regret arbitrarily close to the logarithmic order. The result finds applications in communication networks, financial investment, and industrial engineering.

  20. Psychosocial Stress and Sport Injuries in Tennis Players

    Directory of Open Access Journals (Sweden)

    Amador Blas Redondo

    2011-09-01

    Full Text Available The purpose of this study was to assess the perceived social stress and its relation to sports injuries in tennis players. Sixty-three male tennis players, with a mean age of 31.62 years (SD = 8.93, Sports Clubs belonging to the Province of Alicante (Spain completed instruments of psychosocial stress and injuries sustained during the previous year the assessment. The results indicate that life events experienced was related to some of the injuries suffered by players. Relationships were found between the degree of psychological stress experienced and the negative evaluation of this strain, the type (lesions on wrists, ankles and sprains, and severity of injuries (minor injuries.

  1. Experimental implementation of a four-player quantum game

    International Nuclear Information System (INIS)

    Game theory is central to the understanding of competitive interactions arising in many fields, from the social and physical sciences to economics. Recently, as the definition of information is generalized to include entangled quantum systems, quantum game theory has emerged as a framework for understanding the competitive flow of quantum information. Up till now, only two- and three-player quantum games have been demonstrated with restricted strategy sets. Here, we report the first experiment that implements a four-player quantum minority game over tunable four-partite entangled states encoded in the polarization of single photons. Experimental application of appropriate player strategies gives equilibrium payoff values well above those achievable in the classical game. These results are in excellent quantitative agreement with our theoretical analysis of the symmetric Pareto optimal strategies. Our results demonstrate for the first time how nontrivial equilibria can arise in a competitive situation involving quantum agents.

  2. Procedural Personas for Player Decision Modeling and Procedural Content Generation

    DEFF Research Database (Denmark)

    Holmgård, Christoffer

    2016-01-01

    How can player models and artificially intelligent (AI) agents be useful in early-stage iterative game and simulation design? One answer may be as ways of generating synthetic play-test data, before a game or level has ever seen a player, or when the sampled amount of play test data is very low....... This thesis explores methods for creating low-complexity, easily interpretable, generative AI agents for use in game and simulation design. Based on insights from decision theory and behavioral economics, the thesis investigates how player decision making styles may be defined, operationalised, and measured...... in specific games. It further explores how simple utility functions, easily defined and changed by game designers, can be used to construct agents expressing a variety of decision making styles within a game, using a variety of contemporary AI approaches, naming the resulting agents "Procedural Personas...

  3. Adaptations to speed endurance training in highly trained soccer players

    DEFF Research Database (Denmark)

    Nyberg, Michael Permin; Fiorenza, Matteo; Lund, Anders;

    2016-01-01

    PURPOSE: The present study examined whether a period of additional speed endurance training would improve intense intermittent exercise performance in highly trained soccer players during the season and whether the training changed aerobic metabolism and the level of oxidative enzymes in type I...... and II muscle fibers. METHODS: During the last nine weeks of the season, thirteen semi-professional soccer players performed additional speed endurance training sessions consisting of 2-3 sets of 8 - 10 repetitions of 30 m sprints with 10 s of passive recovery (SET). Before and after SET, subjects...... in type I and II fibers did not change. CONCLUSION: In highly trained soccer players, additional speed endurance training is associated with an improved ability to perform repeated high-intensity work. To what extent the training-induced changes in V˙O2 kinetics and mechanical efficiency in type I fibers...

  4. Speed and power preparation of qualified water polo players

    Directory of Open Access Journals (Sweden)

    Ostrovs'kij M.V.

    2013-02-01

    Full Text Available The scientific information of the improve of power and speed preparation of qualified water polo players were presented in the article. The application of power training exercises, similar in structure and composition with competitive acts of water polo players and also their purposeful use for developing power endurance, ultimate speed and explosive power, ensure their greatest development. It has been recognized determined that the use of speed training exercises in the middle of the training session is the most effective. In water polo training the practice of developing speed skills at the end of training session is the least effective. Combination of speed qualities training variants at different parts of training session throughout the year-round cycle of training adds the positive effect of speed qualification of water polo players in general.

  5. Effects of Thai massage on physical fitness in soccer players.

    Science.gov (United States)

    Hongsuwan, Chanawong; Eungpinichpong, Wichai; Chatchawan, Uraiwan; Yamauchi, Junichiro

    2015-02-01

    [Purpose] The aim of this study was to determine the effects of Thai massage on physical fitness in soccer players. [Subjects and Methods] Thirty-four soccer players were randomly assigned to receive either rest (the control group) or three 30-minute sessions of Thai massage over a period of 10 days. Seven physical fitness tests consisting of sit and reach, hand grip strength, 40 yards technical agility, 50-meter sprint, sit-ups, push-ups, and VO2, max were measured before and after Thai massage or rest. [Results] All the physical fitness tests were significantly improved after a single session of Thai massage, whereas only the sit and reach, and the sit-ups tests were improved in the control group. [Conclusion] Thai massage could provide an improvement in physical performance in soccer players. PMID:25729203

  6. Two-player envy-free multi-cake division

    CERN Document Server

    Cloutier, John; Su, Francis Edward

    2009-01-01

    We introduce a generalized cake-cutting problem in which we seek to divide multiple cakes so that two players may get their most-preferred piece selections: a choice of one piece from each cake, allowing for the possibility of linked preferences over the cakes. For two players, we show that disjoint envy-free piece selections may not exist for two cakes cut into two pieces each, and they may not exist for three cakes cut into three pieces each. However, there do exist such divisions for two cakes cut into three pieces each, and for three cakes cut into four pieces each. The resulting allocations of pieces to players are Pareto-optimal with respect to the division. We use a generalization of Sperner's lemma on the polytope of divisions to locate solutions to our generalized cake-cutting problem.

  7. Mega Key Authentication Mechanism

    OpenAIRE

    Kloss, Guy

    2016-01-01

    For secure communication it is not just sufficient to use strong cryptography with good and strong keys, but to actually have the assurance, that the keys in use for it are authentic and from the contact one is expecting to communicate with. Without that, it is possible to be subject to impersonation or man-in-the-middle (MitM) attacks. Mega meets this problem by providing a hierarchical authentication mechanism for contacts and their keys. To avoid any hassle when using multiple types of key...

  8. Safety tennis courts ensuring performance of players

    OpenAIRE

    Sanchís Almenara, Mercedes; Alcantara Alcover, Enrique; Gimeno Peña, Sonia; Magraner Llavador, Laura; Parrilla Bernabé, Eduardo; Moraga Maestre, Ramón; Matey González, Francisco José; Alemany Mut, Mª Sandra

    2013-01-01

    [EN] Shoe surface interaction is a key factor in tennis due to this is a very quick play. A poor friction normally will mean slips and lost points, and an excessive friction will probably cause injuries due to high loads in joints like knee and ankle. In this sense, the objective of the project coordinated by ITF and developed in collaboration with IBV, Sheffield University and INCOTEC, is to develop a device to evaluate shoe-surface interaction in tennis ...

  9. Nosema Tolerant Honeybees (Apis mellifera) Escape Parasitic Manipulation of Apoptosis

    Science.gov (United States)

    Kurze, Christoph; Le Conte, Yves; Dussaubat, Claudia; Erler, Silvio; Kryger, Per; Lewkowski, Oleg; Müller, Thomas; Widder, Miriam; Moritz, Robin F. A.

    2015-01-01

    Apoptosis is not only pivotal for development, but also for pathogen defence in multicellular organisms. Although numerous intracellular pathogens are known to interfere with the host’s apoptotic machinery to overcome this defence, its importance for host-parasite coevolution has been neglected. We conducted three inoculation experiments to investigate in the apoptotic respond during infection with the intracellular gut pathogen Nosema ceranae, which is considered as potential global threat to the honeybee (Apis mellifera) and other bee pollinators, in sensitive and tolerant honeybees. To explore apoptotic processes in the gut epithelium, we visualised apoptotic cells using TUNEL assays and measured the relative expression levels of subset of candidate genes involved in the apoptotic machinery using qPCR. Our results suggest that N. ceranae reduces apoptosis in sensitive honeybees by enhancing inhibitor of apoptosis protein-(iap)-2 gene transcription. Interestingly, this seems not be the case in Nosema tolerant honeybees. We propose that these tolerant honeybees are able to escape the manipulation of apoptosis by N. ceranae, which may have evolved a mechanism to regulate an anti-apoptotic gene as key adaptation for improved host invasion. PMID:26445372

  10. Nosema Tolerant Honeybees (Apis mellifera Escape Parasitic Manipulation of Apoptosis.

    Directory of Open Access Journals (Sweden)

    Christoph Kurze

    Full Text Available Apoptosis is not only pivotal for development, but also for pathogen defence in multicellular organisms. Although numerous intracellular pathogens are known to interfere with the host's apoptotic machinery to overcome this defence, its importance for host-parasite coevolution has been neglected. We conducted three inoculation experiments to investigate in the apoptotic respond during infection with the intracellular gut pathogen Nosema ceranae, which is considered as potential global threat to the honeybee (Apis mellifera and other bee pollinators, in sensitive and tolerant honeybees. To explore apoptotic processes in the gut epithelium, we visualised apoptotic cells using TUNEL assays and measured the relative expression levels of subset of candidate genes involved in the apoptotic machinery using qPCR. Our results suggest that N. ceranae reduces apoptosis in sensitive honeybees by enhancing inhibitor of apoptosis protein-(iap-2 gene transcription. Interestingly, this seems not be the case in Nosema tolerant honeybees. We propose that these tolerant honeybees are able to escape the manipulation of apoptosis by N. ceranae, which may have evolved a mechanism to regulate an anti-apoptotic gene as key adaptation for improved host invasion.

  11. Apoptosis detection in histological sections

    Czech Academy of Sciences Publication Activity Database

    Matalová, Eva; Dubská, Lenka; Míšek, Ivan

    2003-01-01

    Roč. 72, č. 7 (2003), s. 18-19. ISSN 0001-7213. [Congress of the European Association of Veterinary Anatomists/24./. 21.07.2002-25.07.2002, Brno] R&D Projects: GA ČR GP204/02/P112 Institutional research plan: CEZ:AV0Z5045916 Keywords : apoptosis Subject RIV: FF - HEENT, Dentistry

  12. Evolving and coevolving computer go players using neuroevolution.

    OpenAIRE

    Zela Moraya, Wester Edison; Zato Recellado, Jose Gabriel

    2011-01-01

    The Go game is ancient very complex game with simple rules which still is a challenge for the AI.This work cover some neuroevolution techniques used in reinforcement learning applied to the GO game as SANE (Symbiotic Adaptive Neuro-Evolution) and presents a variation to this method with the intention of evolving better strategies in the game. The computer Go player based in SANE is evolved againts a knowed player which creates some problem as determinism for which is proposed the co-evolution...

  13. Developing computer aided model for selecting players in badminton

    Directory of Open Access Journals (Sweden)

    Ali Ağılönü

    2009-09-01

    Full Text Available The purpose of this study is to develop a decision support model for selecting the most appropriate players in Badminton via Fuzzy Multi Attribute Decision Making (FMADM algorithm. Developed model has been applied on active Badminton players in age between 9 and 11 among Muğla Province by using the data of player’s physical appropriateness scores and technical observation values in computer environment. In developed model, it has been ensured that using both significant criteria and the weights of criteria make results more sensitive. Finally, it is proved that model’s results are appropriate and consistent.

  14. The expected-outcome model of two-player games

    CERN Document Server

    Abramson, Bruce

    1990-01-01

    The Expected-Outcome Model of Two-Player Games deals with the expected-outcome model of two-player games, in which the relative merit of game-tree nodes, rather than board positions, is considered. The ambiguity of static evaluation and the problems it generates in the search system are examined and the development of a domain-independent static evaluator is described. Comprised of eight chapters, this book begins with an overview of the rationale for the mathematical study of games, followed by a discussion on some previous artificial intelligence (AI) research efforts on game-trees. The nex

  15. Radiographic knee osteoarthritis in ex-elite table tennis players

    Directory of Open Access Journals (Sweden)

    Rajabi Reza

    2012-02-01

    Full Text Available Abstract Background Table tennis involves adoption of the semi-flexed knee and asymmetrical torsional trunk movements creating rotational torques on the knee joint which may predispose players to osteoarthritis (OA of the knee. This study aims to compare radiographic signs of knee OA and associated functional levels in ex-elite male table tennis players and control subjects. Methods Study participants were 22 ex-elite male table tennis players (mean age 56.64 ± 5.17 years with 10 years of involvement at the professional level and 22 non-athletic males (mean age 55.63 ± 4.08 years recruited from the general population. A set of three radiographs taken from each knee were evaluated by an experienced radiologist using the Kellgren and Lawrence (KL scale (0-4 to determine radiographic levels of OA severity. The intercondylar distance was taken as a measure of lower limb angulation. Participants also completed the pain, stiffness, and physical function categories of the Western Ontario and McMaster University Osteoarthritis Index (WOMAC 3.1 questionnaire. Results The results showed 78.3% of the ex-elite table tennis players and 36.3% of controls had varying signs of radiographic knee OA with a significant difference in the prevalence levels of definite radiographic OA (KL scale > 2 found between the two groups (P ≤ 0.001. Based on the WOMAC scores, 68.2% of the ex-elite table tennis players reported symptoms of knee pain compared with 27.3% of the controls (p = 0.02 though no significant differences were identified in the mean physical function or stiffness scores between the two groups. In terms of knee alignment, 73.7% of the ex-elite athletes and 32% of the control group had signs of altered lower limb alignment (genu varum (p = 0.01. Statistical differences were found in subjects categorized as having radiographic signs of OA and altered lower limb alignment (p = 0.03. Conclusions Ex-elite table tennis players were found to have increased

  16. Generative Agents for Player Decision Modeling in Games

    DEFF Research Database (Denmark)

    Holmgård, Christoffer; Liapis, Antonios; Togelius, Julian;

    2014-01-01

    ’s internal decision making processes. Such agents can then be used to interpret human decision making, as personas and playtesting tools in the game design process, as baselines for adapting agents to mimic classes of human players, or as believable, human-like opponents. This argument is explored in a...... crowdsourced decision making experiment, in which the decisions of human players are recorded in a small-scale dungeon themed puzzle game. Human decisions are compared to the decisions of a number of a priori defined “archetypical” agent-personas, and the humans are characterized by their likeness to or...

  17. The multi-player performance-enhancing drug game.

    Directory of Open Access Journals (Sweden)

    Kjetil K Haugen

    Full Text Available This paper extends classical work on economics of doping into a multi-player game setting. Apart from being among the first papers formally formulating and analysing a multi-player doping situation, we find interesting results related to different types of Nash-equilibria (NE. Based mainly on analytic results, we claim at least two different NE structures linked to the choice of prize functions. Linear prize functions provide NEs characterised by either everyone or nobody taking drugs, while non-linear prize functions lead to qualitatively different NEs with significantly more complex predictive characteristics.

  18. Self-esteem and injury in competitive field hockey players.

    Science.gov (United States)

    Kolt, G S; Roberts, P D

    1998-08-01

    A volunteer sample of 50 competitive field hockey players completed the Coopersmith Self-esteem Inventory at pre- and postseason and prospectively collected injury data over a 20-wk. season. Multiple regression analysis showed no relationship between scores on Self-esteem and the number of injuries, the participation time affected due to injury, and sex of players. Further multiple regression analysis showed that frequency of the more severe injuries significantly predicted scores on Self-esteem. This finding can be interpreted as evidence of the relationship between low self-esteem and injury in sport. PMID:9760670

  19. Virtual Power Players Internal Negotiation and Management in MASCEM

    DEFF Research Database (Denmark)

    Santos, Gabriel; Pinto, Tiago; Vale, Zita; Praca, Isabel; Morais, Hugo

    2013-01-01

    Electricity Markets are not only a new reality but an evolving one as the involved players and rules change at a relatively high rate. Multi-agent simulation combined with Artificial Intelligence techniques may result in very helpful sophisticated tools. This paper presents a new methodology for...... the management of coalitions in electricity markets. This approach is tested using the multi-agent market simulator MASCEM (Multi-Agent Simulator of Competitive Electricity Markets), taking advantage of its ability to provide the means to model and simulate Virtual Power Players (VPP). VPPs are...

  20. Short Duration Heat Acclimation in Australian Football Players

    OpenAIRE

    Kelly, Monica; Gastin, Paul B.; Dwyer, Daniel B; Sostaric, Simon; Snow, Rodney J.

    2016-01-01

    This study examined if five sessions of short duration (27 min), high intensity, interval training (HIIT) in the heat over a nine day period would induce heat acclimation in Australian football (AF) players. Fourteen professional AF players were matched for VO2peak (mL·kg-1·min-1) and randomly allocated into either a heat acclimation (Acc) (n = 7) or Control (Con) group (n = 7). The Acc completed five cycle ergometer HIIT sessions within a nine day period on a cycle ergometer in the heat (38....

  1. Modeling the Semiotic Structure of Player-Characters

    DEFF Research Database (Denmark)

    Vella, Daniel

    2014-01-01

    from the fields of narratology and literary theory to highlight the double-layered ontology of character as both a possible individual and as a semiotic construction. Uri Margolin’s narratological model of character signification is used as the basis for developing a semiotic-structural model of the...... player-character that addresses its specific medialities and formal nature – a task which is performed through illustrative close examinations of the player-characters in The Last of Us (Naughty Dog 2013) and Gone Home (The Fullbright Company 2013)....

  2. Particle Swarm Optimization of Electricity Market Negotiating Players Portfolio

    DEFF Research Database (Denmark)

    Pinto, Tiago; Vale, Zita; Sousa, Tiago;

    2014-01-01

    Energy systems worldwide are complex and challenging environments. Multi-agent based simulation platforms are increasing at a high rate, as they show to be a good option to study many issues related to these systems, as well as the involved players at act in this domain. In this scope the authors......, based on particle swarm optimization, which provides the best investment profile for a market player, considering different market opportunities (bilateral negotiation, market sessions, and operation in different markets) and the negotiation context such as the peak and off-peak periods of the day, the...

  3. Effects of Thai massage on physical fitness in soccer players

    OpenAIRE

    Hongsuwan, Chanawong; Eungpinichpong, Wichai; Chatchawan, Uraiwan; Yamauchi, Junichiro

    2015-01-01

    [Purpose] The aim of this study was to determine the effects of Thai massage on physical fitness in soccer players. [Subjects and Methods] Thirty-four soccer players were randomly assigned to receive either rest (the control group) or three 30-minute sessions of Thai massage over a period of 10 days. Seven physical fitness tests consisting of sit and reach, hand grip strength, 40 yards technical agility, 50-meter sprint, sit-ups, push-ups, and VO2, max were measured before and after Thai mass...

  4. Comparison of Ball-And-Racket Impact Force in Two-Handed Backhand Stroke Stances for Different-Skill-Level Tennis Players

    Science.gov (United States)

    Lo, Kuo-Cheng; Hsieh, Yung-Chun

    2016-01-01

    This study compared the kinetic roles of the upper extremities in racket impact force generation between the open stance (OS) and square stance (SS) for tennis players with different skill levels in two-handed backhand strokes. Twelve male tennis players were divided into an advanced group (AG) (L3-L2 skill level) and intermediate group (IG) (L7-L6 skill level), and their data were used in a three-dimensional kinetic analysis. Their motions were captured using 21 reflective markers attached to anatomic landmarks for two-handed backhand stroke motion data collection. During the acceleration phase, significant differences were not observed between both stances, but they were observed between the groups with different skill levels for the force of the upper extremities (p = 0.027). The joint forces were significantly lower in the AG than in the IG. Players performing the SS had significantly larger pronation and supination of the wrist joint moment than those in the OS (p = 0.032) during the acceleration phase, irrespective of the playing level. Higher internal rotation moment after impact was observed at each joint, particularly among young intermediate tennis players, regardless of their stance. The AG demonstrated a higher joint force and moment at every joint compared with the IG at impact. Moreover, the AG demonstrated superior stroke efficiency and effectively reduced joint moment after impact and sports injury. Key points Advanced players, regardless of open stance or square stance, have larger joint force and moment at each joint before ball impact resulting in better stroke efficiency and reduced chance of injury. Intermediate players, regardless of stance, have higher internal rotation moment at each joint instead of larger joint force as compared to advanced players before ball impact. The higher internal rotation moment will induce higher joint impact force which makes the player injury-prone. Young intermediate tennis players may want to avoid excessive

  5. Comparison of Ball-And-Racket Impact Force in Two-Handed Backhand Stroke Stances for Different-Skill-Level Tennis Players.

    Science.gov (United States)

    Lo, Kuo-Cheng; Hsieh, Yung-Chun

    2016-06-01

    This study compared the kinetic roles of the upper extremities in racket impact force generation between the open stance (OS) and square stance (SS) for tennis players with different skill levels in two-handed backhand strokes. Twelve male tennis players were divided into an advanced group (AG) (L3-L2 skill level) and intermediate group (IG) (L7-L6 skill level), and their data were used in a three-dimensional kinetic analysis. Their motions were captured using 21 reflective markers attached to anatomic landmarks for two-handed backhand stroke motion data collection. During the acceleration phase, significant differences were not observed between both stances, but they were observed between the groups with different skill levels for the force of the upper extremities (p = 0.027). The joint forces were significantly lower in the AG than in the IG. Players performing the SS had significantly larger pronation and supination of the wrist joint moment than those in the OS (p = 0.032) during the acceleration phase, irrespective of the playing level. Higher internal rotation moment after impact was observed at each joint, particularly among young intermediate tennis players, regardless of their stance. The AG demonstrated a higher joint force and moment at every joint compared with the IG at impact. Moreover, the AG demonstrated superior stroke efficiency and effectively reduced joint moment after impact and sports injury. Key pointsAdvanced players, regardless of open stance or square stance, have larger joint force and moment at each joint before ball impact resulting in better stroke efficiency and reduced chance of injury.Intermediate players, regardless of stance, have higher internal rotation moment at each joint instead of larger joint force as compared to advanced players before ball impact. The higher internal rotation moment will induce higher joint impact force which makes the player injury-prone.Young intermediate tennis players may want to avoid excessive

  6. The relationship between isometric and dynamic strength in college football players.

    Science.gov (United States)

    McGuigan, Michael R; Winchester, Jason B

    2008-01-01

    Previous research has demonstrated the importance of both dynamic and isometric maximal strength and rate of force development (RFD) in athletic populations. The purpose of this study was to examine the relationships between measures of isometric force (PF), RFD, jump performance and strength in collegiate football athletes. The subjects in this study were twenty-two men [(mean ± SD):age 18.4 ± 0.7 years; height 1.88 ± 0.07 m; mass 107.6 ± 22.9 kg] who were Division I college football players. They were tested for PF using the isometric mid thigh pull exercise. Explosive strength was measured as RFD from the isometric force-time curve. The one repetition maximum (1RM) for the squat, bench press and power clean exercises were determined as measures of dynamic strength. The two repetition maximum (2RM) for the split jerk was also determined. Vertical jump height and broad jump was measured to provide an indication of explosive muscular power. There were strong to very strong correlations between measures of PF and 1RM (r = 0. 61 - 0.72, p clean 1RM and squat 1RM (r = 0.90, p jerk and clean 1RM (r = 0.71, p < 0.05), squat 1RM (r = 0.71, p < 0.05), bench 1RM (r = 0.70, p < 0.05) and PF (r = 0.72, p < 0.05). There were no significant correlations with RFD. The isometric mid thigh pull test does correlate well with 1RM testing in college football players. RFD does not appear to correlate as well with other measures. The isometric mid thigh pull provides an efficient method for assessing isometric strength in athletes. This measure also provides a strong indication of dynamic performance in this population. Key pointsIn Division I college football players the isometric mid thigh pull test correlates well with 1RM testing.Rate of Force Development does not appear to be as closely related to dynamic and isometric strength in college football players.The isometric mid thigh pull provides a quick and efficient method for assessing isometric strength in athletes. PMID

  7. Jump Rope Training: Balance and Motor Coordination in Preadolescent Soccer Players

    Science.gov (United States)

    Trecroci, Athos; Cavaggioni, Luca; Caccia, Riccardo; Alberti, Giampietro

    2015-01-01

    General physical practice and multidimensional exercises are essential elements that allow young athletes to enhance their coordinative traits, balance, and strength and power levels, which are linked to the learning soccer-specific skills. Jumping rope is a widely-used and non-specific practical method for the development of athletic conditioning, balance and coordination in several disciplines. Thus, the aim of this study was to investigate the effects of a short-term training protocol including jumping rope (JR) exercises on motor abilities and body balance in young soccer players. Twenty-four preadolescent soccer players were recruited and placed in two different groups. In the Experimental group (EG), children performed JR training at the beginning of the training session. The control group (CG), executed soccer specific drills. Harre circuit test (HCT) and Lower Quarter Y balance test (YBT-LQ) were selected to evaluate participant’s motor ability (e.g. ability to perform rapidly a course with different physical tasks such as somersault and passages above/below obstacles ) and to assess unilateral dynamic lower limb balance after 8 weeks of training. Statistical analysis consisted of paired t-test and mixed analysis of variance scores to determine any significant interactions. Children who performed jumping rope exercises showed a significant decrease of 9% (p 0.05, ES = 0.05-0.2) from pre- to post-training. A training-by-group interaction was found for the composite score in both legs (p 0.14). Our findings demonstrated that JR practice within regular soccer training enhanced general motor coordination and balance in preadolescent soccer players. Therefore, the inclusion of JR practice within regular soccer training session should encouraged to improve children’s motor skills. Key points Performing jumping rope exercises within a regular soccer program can be an additional method to improve balance and motor coordination. The performance improvement in

  8. The female player does not exist: gender identity relates to differences in player motivations and play styles.

    Science.gov (United States)

    Poels, Karolien; De Cock, Nele; Malliet, Steven

    2012-11-01

    This study addresses the female player of massively multiplayer online (role-playing) games and investigates how gender identity (GI), indicating a person's identification with characteristics that are traditionally defined as masculine or feminine, can be used to explain playing patterns within the female gender group. Results from an online survey (n=466) show that females' player motivations and play styles vary as a function of their GI, indicating that it is a relevant and additional predictor of play behavior and confirming that female play behavior cannot be generalized based on stereotypical male/female conceptions. PMID:23020745

  9. Study: Ex-NFL Players Aren't At Greater Risk for Suicide

    Science.gov (United States)

    ... NFL Players Aren't at Greater Risk for Suicide Rate was lower than would be expected among ... football players aren't at greater risk of suicide than the general U.S. population, federal health officials ...

  10. Physical preparedness and functional status of young players in the competition period

    Directory of Open Access Journals (Sweden)

    Svystun Yu.D.

    2014-11-01

    Full Text Available Purpose : evaluate physical preparedness and functional status of young players in the competitive period. Material : the study involved two groups of players. One group - 18 athletes aged 13 years. The second group - 16 players aged 14-16 years. Athletes performed tests: running 15 m stroke and 15 m, 30 m from the spot. Determines the amount of creatinine in the urine of athletes. Results : the evaluation of physical preparedness of young players indicates a decrease in the speed of the players, as evidenced by indicators and creatinine excretion in the urine. Revealed hypertrophy of the left ventricle, systolic blood volume. Functional state of the older age group athletes is somewhat better than the younger players. Analysis of the studied parameters indicates incomplete recovery of the body of young players. Conclusions : It is recommended to use the results to correct the training process of young players.

  11. Postural stability decreases in elite young soccer players after a competitive soccer match

    DEFF Research Database (Denmark)

    Brito, João; Fontes, Ivo; Ribeiro, Fernando;

    2012-01-01

    To investigate the effects of an official soccer match on postural stability in youth elite soccer players.......To investigate the effects of an official soccer match on postural stability in youth elite soccer players....

  12. EcoTRADE - a multi player network game of a tradable permit market for biodiversity credits

    CERN Document Server

    Hartig, Florian; Drechsler, Martin

    2008-01-01

    EcoTRADE is a multi player network game of a virtual biodiversity credit market. Each player controls the land use of a certain amount of parcels on a virtual landscape. The biodiversity credits of a particular parcel depend on neighboring parcels, which may be owned by other players. The game can be used to study the strategies of players in experiments or classroom games and also as a communication tool for stakeholders participating in credit markets that include spatially interdependent credits.

  13. Dental Trauma and Mouthguard Usage among Soccer Players in Izmir, Turkey

    OpenAIRE

    Ilhan Uzel; Arzu Aykut-Yetkiner; Nazan Ersin; Fahinur Ertugrul; Ozant Oncag; Rengin Attin

    2014-01-01

    The aims of this study were to verify the occurrence of dental injuries in 343 amateur Turkish soccer players in İzmir and the level of knowledge of the teams’ soccer players about mouthguards. The soccer players were interviewed to determine the occurrence of dental trauma during soccer and mouthguard usage level. The data were analyzed with descriptive analysis to determine absolute and relative frequencies of answers for each one of the questions. Only 35 (10.2%) soccer players reported th...

  14. How do clarinet players adjust the resonances of their vocal tracts for different playing effects

    OpenAIRE

    Fritz, Claudia; Wolfe, Joe

    2005-01-01

    In a simple model, the reed of the clarinet is mechanically loaded by the series combination of the acoustical impedances of the instrument itself and of the player's vocal tract. Here we measure the complex impedance spectrum of players' tracts using an impedance head adapted to fit inside a clarinet mouthpiece. A direct current shunt with high acoustical resistance allows players to blow normally, so the players can simulate the tract condition under playing conditions. The reproducibility ...

  15. Posterior shoulder tightness and rotator cuff strength assessments in painful shoulders of amateur tennis players

    OpenAIRE

    Marcondes, Freddy B.; Julio F. Jesus; Flavio F. Bryk; Vasconcelos, Rodrigo A.; Thiago Y. Fukuda

    2013-01-01

    BACKGROUND: Previous studies have shown a relationship between shoulder posterior capsule tightness and shoulder pain in overhead athletes. However, this relationship has not been studied in tennis players. OBJECTIVES: Assessment of the shoulder range of motion (ROM), strength and posterior capsule tightness of skilled amateur tennis players who had complaints of dominant shoulder pain in comparison with tennis players without pain. METHOD: Forty-nine skilled amateur tennis players we...

  16. EFFECT OF NEGATIVE EMOTIONAL RESPONSE TO COMPETITIVE STRESSORS ON SPORTS ACHIEVEMENTS OF BASKETBALL PLAYERS

    OpenAIRE

    Santosh Bajpai; Avinash Yadav

    2016-01-01

    The aim of the present study is to compare sports competitive anxiety between national, state and district level male basketball players. For present study, 100 national level male basketball players (Ave. age 25.12 yrs.), 100 state level male basketball players (Ave. age 22.34 yrs.) and 100 district level male basketball players (Ave. age 21.92 yrs.) were selected as sample. The sample was collected through convenience sampling method. Sports Competitive Anxiety Test (SCAT) constructed and s...

  17. Factors associated with deep tissue injury in male wheelchair basketball players of a Japanese national team

    Directory of Open Access Journals (Sweden)

    Hirotaka Mutsuzaki

    2014-04-01

    Full Text Available Maintenance of the sporting activity of elite athletes in adapted sports can be difficult if a secondary disorder, such as a pressure ulcer, occurs. Pressure ulcers result from deep tissue injuries by external pressure. The purpose of this study was to use ultrasonography to investigate deep tissue injuries in male wheelchair basketball players of a Japanese national team, and to determine factors associated with the injuries (e.g., body mass index, class of wheelchair basketball, underlying disease, length of athletic career, and whether use of wheelchair is primarily for playing basketball. Twenty male Japanese wheelchair basketball players on the national team for the 2012 London Paralympic Games (12 representative players and eight candidate representative players participated in this study. The sacral region and bilateral ischial regions in each athlete were examined by ultrasonography to detect low-echoic lesions indicative of deep tissue injuries. Nine (45% players had low-echoic lesions, which were detected in 10 of 60 areas. Eight lesions were detected in the sacral region and two lesions were detected in the ischial region. More players with spinal cord injury had low-echoic lesions [9 (69.2% of 13 players], compared to players with skeletal system disease [0 (0% of 7 players, p = 0.002]. Players who used a wheelchair in daily life were more likely to have low-echoic lesions [8 (66.74% of 12 players], compared to players who primarily used a wheelchair for playing basketball [1 (12.5% of 8 players, p = 0.010]. Deep tissue injuries were detected in 45% of male Japanese wheelchair basketball players on the national team. Players with spinal cord injury and players who used a wheelchair in daily life were more likely to have deep tissue injuries, particularly in the sacral region. The lesions were small, but a periodic medical check should be performed to maintain athletes' sporting life.

  18. The role of apoptosis in pulmonary fibrosis

    Directory of Open Access Journals (Sweden)

    B. D. Uhal

    2008-12-01

    Full Text Available Apoptosis has been defined as "gene-directed cellular self-destruction" and is an active process that is tightly regulated by a number of gene products, which promote or block cell death. Apoptotic death can be triggered by a wide variety of stimuli and, importantly, not all cells necessarily undergo apoptosis in response to the same stimulus. Abnormal regulation of apoptosis has been implicated in a wide range of diseases and approaches to modifying apoptosis represent important future therapeutic strategies. Idiopathic pulmonary fibrosis (IPF is a progressive and relentless disease involving scarring of the lung, which has been recognised as the most lethal interstitial lung disease. In the lungs of IPF patients, increased epithelial apoptosis, together with decreased apoptosis of myofibroblasts, represents persistent findings (particularly in areas of collagen deposition supporting an interaction between altered apoptosis and the pathogenesis of the disease. Data from human tissues and animal models are refining current knowledge of the processes involved in this pathogenesis. This has challenged the dogma that IPF is purely a disease of unresolved inflammation by emphasising the central roles played by the alveolar epithelial cell and myofibroblasts and, as part of that role, the importance of altered apoptosis. Evidence suggests blockade of epithelial cell apoptosis can prevent subsequent collagen deposition, and induction of myofibroblast apoptosis, at least theoretically, would be expected to resolve ongoing fibrosis. These two concepts raise the prospect of therapeutic intervention aimed at modifying apoptosis and, thus, fibrosis in idiopathic pulmonary fibrosis.

  19. Personality and Injury Risk Among ‎Professional Hockey Players

    Directory of Open Access Journals (Sweden)

    David C. Schwebel

    2009-07-01

    Full Text Available Background: Although much is known about risk for athletic injury, research on the roles of individual differences in personality and temperament on athletic injury has lagged. We hypothesized that professional athletes with high sensation-seeking and extraversion scores, and with low effortful control scores, would experience more injuries over the course of a season, would have more severe injuries, and would miss more total days of play. Methods: Prospective design with questionnaire report at time one and injury tracking throughout an 18-week athletic season. Setting: Professional hockey team in the United States. Participants: Eighteen professional hockey players (ages 21-33. Measurements: Players completed self-report personality (Sensation-Seeking Scale, Form V and temperament (the Adult Temperament Questionnaire measures. Quantity and severity of injury, as well as playing time missed, were tracked for 18 weeks. Results: On average, players experienced almost 6 injuries causing a loss of 10 playing days through the season. Those players scoring high on Boredom Susceptibility and Total Sensation-Seeking incurred more total injuries. Those scoring high on temperamental neutral perceptual sensitivity suffered more severe injuries. Conclusions: Athletes who suffered more injuries reported a preference for stimulating environments and boredom with non-stimulating environments. Injury severity was not correlated with sensation-seeking but was related to temperamental perceptual sensitivity. Implications for identification of injury-prone athletes, pre-injury training, and post-injury treatment are discussed.

  20. Predicting the Winner in Two Player StarCraft Games

    OpenAIRE

    Sánchez Ruíz-Granados, Antonio

    2015-01-01

    In this paper we compare different machine learning algorithms to predict the outcome of 2 player games in StarCraft, a wellknown Real-Time Strategy (RTS) game. In particular we discuss the game state representation, the accuracy of the prediction as the game progresses, the size of the training set and the stability of the predictions.

  1. LIPOSARCOMA OF THE KNEE IN A TENNIS PLAYER: CASE REPORT

    Science.gov (United States)

    Filho, Jorge Sayum; Sayum, Jorge; de Carvalho, Rogério Teixeira; Garms, Emerson; Ramos, Leonardo Addeo; Matsuda, Marcelo Mitsura; Ejnisman, Benno; Cohen, Moisés

    2015-01-01

    Liposarcoma is an uncommon malignant tumor. It originates in the mesenchymal cells, and is the most common of the soft tissue sarcomas. The authors report a case of a 40 year-old male tennis player with liposarcoma in the posterior right knee and distal thigh region. PMID:27047841

  2. Monitoring load, recovery and performance in young elite soccer players

    NARCIS (Netherlands)

    Brink, Michel S.; Nederhof, Esther; Visscher, Chris; Schmikli, Sandor L.; Lemmink, Koen A. P. M.

    2010-01-01

    Brink, MS, Nederhof, E, Visscher, C, Schmikli, SL, and Lemmink, KAPM. Monitoring load, recovery, and performance in young elite soccer players. J Strength Cond Res 24(3): 597603, 2010-The purpose of this study was to investigate the relation between training load, recovery, and monthly field test pe

  3. "Badminton Player-Coach" Interactions between Failing Students

    Science.gov (United States)

    Mascret, Nicolas

    2011-01-01

    Background: Physical education teachers often use the player-coach dyad in individual opposition sports so that students can obtain information on their actions and then better regulate them. This type of work also develops methodological and social skills. However, the task of observing a partner often poses problems for failing students, who…

  4. LIPOSARCOMA OF THE KNEE IN A TENNIS PLAYER: CASE REPORT

    OpenAIRE

    Filho, Jorge Sayum; Sayum, Jorge; de Carvalho, Rogério Teixeira; Garms, Emerson; Ramos, Leonardo Addeo; Matsuda, Marcelo Mitsura; Ejnisman, Benno; Cohen, Moisés

    2015-01-01

    Liposarcoma is an uncommon malignant tumor. It originates in the mesenchymal cells, and is the most common of the soft tissue sarcomas. The authors report a case of a 40 year-old male tennis player with liposarcoma in the posterior right knee and distal thigh region.

  5. Foot Posture and Patellar Tendon Pain Among Adult Volleyball Players

    NARCIS (Netherlands)

    de Groot, Reinier; Malliaras, Peter; Munteanu, Shannon; Payne, Craig; Morrissey, Dylan; Maffulli, Nicola

    2012-01-01

    Objective: We hypothesized that individuals with a normal foot posture would be less likely to experience patellar tendon pain and pathology than those with a pronated or supinated foot. Design: Observational study. Setting: Field-based study among competing athletes. Participants: Volleyball player

  6. Division IAA Football Players and Risk Factors for Metabolic Syndrome

    Science.gov (United States)

    Repovich, Wendy E. S.; Babcock, Garth J.

    2012-01-01

    The purpose of this study was to determine if body composition and blood pressure (BP), two markers for Metabolic Syndrome (MetS), were correlated in college football players. Height, weight, BMI, systolic (SBP) and Diastolic (DBP) blood pressure and body composition (three measures) were assessed in a Division IAA football team (N = 55). Data…

  7. Nandrolone- induced myocardial infarction in a professional soccer player

    OpenAIRE

    MB Sharifkazemi; J Kojury; S Shahrzad; M. Zamirian; AR Moaref

    2007-01-01

    Androgenic Anabolic Steroids (AAS) are often used by athletes for enhancing athletic performance but are strongly associated with detrimental cardiovascular effects including sudden cardiac death1. Herein, we present a 24 year-old professional soccer player who suffered acute myocardial infarction after nandrolone consumption

  8. Evolving FPS Game Players by Using Continuous EDA-RL

    OpenAIRE

    Tsubota, Hajime; Handa, Hisashi

    2009-01-01

    This paper extends EDA-RL, Estimation of Distribution Algorithms for Reinforcement Learning Problems, to continuous domain. The extended EDA-RL is used to constitiute FPS game players. In order to cope with continuous input-output relations, Gaussian Network is employed as in EBNA. Simulation results on Unreal Tournament 2004, one of major FPS games, confirm the effectiveness of the proposed method.

  9. The Player, the Controller and the amazing Avatar

    DEFF Research Database (Denmark)

    Sandvik, Kjetil

    and biological organism, robot teleology and human goals" as a starting point, this paper examines the phenomenological, cognitive and aesthetical implications of introducing interface-designs such as the Weemote of the Nintendo Wii console which allow for the player to use her entire body instead of just her...

  10. Medium-term Mortality of Dutch Professional Soccer Players

    NARCIS (Netherlands)

    Koning, Ruud H.; Amelink, Remko

    2012-01-01

    Professional athletes such as soccer players are expected to be in better health than the average member of their age cohort, if only because of the very demands imposed on them by their profession. Moreover, during their active career, their health is monitored on a regular basis. However, whenever

  11. SYNDESMOTIC ANKLE INJURY REHABILITATION EXERCISE PACKAGE FOR ICE HOCKEY PLAYERS

    OpenAIRE

    Kuznetsov, Vitali

    2013-01-01

    SYNDESMOTIC ANKLE INJURY REHABILITATION EXERCISE PACKAGE FOR ICE HOCKEY PLAYERS Kuznetsov, Vitali Satakunnan ammattikorkeakoulu, Satakunta University of Applied Sciences Degree Programme in Physiotherapy November 2013 Supervisor: Bärlund, Esa Number of pages: 42 Appendices: 2 Keywords: ankle, ice hockey, ice hockey injuries, high ankle sprain, ankle sprain rehabilitation, ankle injury prevention __________________________________________________________________ ...

  12. Hand Grip Strength Vs. Sprint Effectiveness in Amputee Soccer Players

    Directory of Open Access Journals (Sweden)

    Wieczorek Marta

    2015-12-01

    Full Text Available Amputee soccer is one of the types of soccer designed for the disabled, especially those who have undergone amputations, as well as those with extremity dysfunction. The objective of the study was to find the relationship between hand grip strength and sprint time in amputee soccer players. Thirteen field amputee soccer players participated in the study. A SAEHAN hydraulic hand dynamometer manufactured by Jamar was used for hand grip strength measurements. The sprint running test was conducted over a distance of 30 m. The Fusion Smart Speed System was employed for running time measurements. No statistically significant relationships were found between hand grip strength of the left or right hand, and sprint times over 1, 5, 10, 15, 20, 25 and 30 m. Analysis of the running velocity curve of the subjects showed an interesting profile characterized by a 15 meter-long acceleration phase and a significant velocity increase over a distance of 20 – 25 m. The study suggests that there is no relationship between hand grip strength and sprint effectiveness in amputee soccer players. The specificity of locomotion with the use of elbow crutches among elite Polish amputee soccer players probably accounts for the profile of the sprint velocity curve. Extension of the acceleration phase in the sprint run and a velocity increase in the subsequent part of the run were observed.

  13. Muscle Strength and Speed Performance in Youth Soccer Players

    Directory of Open Access Journals (Sweden)

    Peñailillo Luis

    2016-04-01

    Full Text Available This study aimed to examine the relationship between maximum leg extension strength and sprinting performance in youth elite male soccer players. Sixty-three youth players (12.5 ± 1.3 years performed 5 m, flying 15 m and 20 m sprint tests and a zigzag agility test on a grass field using timing gates. Two days later, subjects performed a one-repetition maximum leg extension test (79.3 ± 26.9 kg. Weak to strong correlations were found between leg extension strength and the time to perform 5 m (r = -0.39, p = 0.001, flying 15 m (r = -0.72, p < 0.001 and 20 m (r = -0.67, p < 0.001 sprints; between body mass and 5 m (r = -0.43, p < 0.001, flying 15 m (r = -0.75, p < 0.001, 20 m (r = -0.65, p < 0.001 sprints and agility (r =-0.29, p < 0.001; and between height and 5 m (r = -0.33, p < 0.01 and flying 15 m (r = -0.74, p < 0.001 sprints. Our results show that leg muscle strength and anthropometric variables strongly correlate with sprinting ability. This suggests that anthropometric characteristics should be considered to compare among youth players, and that youth players should undergo strength training to improve running speed.

  14. Hand Grip Strength Vs. Sprint Effectiveness in Amputee Soccer Players.

    Science.gov (United States)

    Wieczorek, Marta; Wiliński, Wojciech; Struzik, Artur; Rokita, Andrzej

    2015-11-22

    Amputee soccer is one of the types of soccer designed for the disabled, especially those who have undergone amputations, as well as those with extremity dysfunction. The objective of the study was to find the relationship between hand grip strength and sprint time in amputee soccer players. Thirteen field amputee soccer players participated in the study. A SAEHAN hydraulic hand dynamometer manufactured by Jamar was used for hand grip strength measurements. The sprint running test was conducted over a distance of 30 m. The Fusion Smart Speed System was employed for running time measurements. No statistically significant relationships were found between hand grip strength of the left or right hand, and sprint times over 1, 5, 10, 15, 20, 25 and 30 m. Analysis of the running velocity curve of the subjects showed an interesting profile characterized by a 15 meter-long acceleration phase and a significant velocity increase over a distance of 20 - 25 m. The study suggests that there is no relationship between hand grip strength and sprint effectiveness in amputee soccer players. The specificity of locomotion with the use of elbow crutches among elite Polish amputee soccer players probably accounts for the profile of the sprint velocity curve. Extension of the acceleration phase in the sprint run and a velocity increase in the subsequent part of the run were observed. PMID:26834881

  15. Adolescents risky MP3-player listening and its psychosocial correlates

    NARCIS (Netherlands)

    Vogel, Ineke; Brug, Johannes; van der Ploeg, Catharina P. B.; Raat, Hein

    2011-01-01

    Analogue to occupational noise-induced hearing loss, MP3-induced hearing loss may be evolving into a significant social and public health problem. To inform prevention strategies and interventions, this study investigated correlates of adolescents' risky MP3-player listening behavior primarily infor

  16. Raynaud´s phenomenon in a slap bass player

    DEFF Research Database (Denmark)

    Jepsen, Jørgen Riis; Simonsen, Jane Angel

    2016-01-01

    OBJECTIVE: Secondary Raynaud’s phenomenon is a frequent condition related to occupational exposure to local vibration but has not been described in musicians. This study aims to describe cold-induced blanching of the right second and (in particular) third digits in a 67-year-old double bass player...

  17. Tales of the Unexpected: Coping among Female Collegiate Volleyball Players

    Science.gov (United States)

    Holt, Nicholas L.; Berg, Kylie-Joy; Tamminen, Katherine A.

    2007-01-01

    The purpose of this study was to examine patterns of appraisal, coping, and coping effectiveness in sport. Ten players from a collegiate female volleyball team were interviewed on two occasions, first in the week before a provincial final playoff tournament and in the week following the tournament. Data were transcribed verbatim and subjected to…

  18. Wireless nanosensors for monitoring concussion of football players

    Science.gov (United States)

    Ramasamy, Mouli; Harbaugh, Robert E.; Varadan, Vijay K.

    2015-04-01

    Football players are more to violent impacts and injuries more than any athlete in any other sport. Concussion or mild traumatic brain injuries were one of the lesser known sports injuries until the last decade. With the advent of modern technologies in medical and engineering disciplines, people are now more aware of concussion detection and prevention. These concussions are often overlooked by football players themselves. The cumulative effect of these mild traumatic brain injuries can cause long-term residual brain dysfunctions. The principle of concussion is based the movement of the brain in the neurocranium and viscerocranium. The brain is encapsulated by the cerebrospinal fluid which acts as a protective layer for the brain. This fluid can protect the brain against minor movements, however, any rapid movements of the brain may mitigate the protective capability of the cerebrospinal fluid. In this paper, we propose a wireless health monitoring helmet that addresses the concerns of the current monitoring methods - it is non-invasive for a football player as helmet is not an additional gear, it is efficient in performance as it is equipped with EEG nanosensors and 3D accelerometer, it does not restrict the movement of the user as it wirelessly communicates to the remote monitoring station, requirement of individual monitoring stations are not required for each player as the ZigBee protocol can couple multiple transmitters with one receiver. A helmet was developed and validated according to the above mentioned parameters.

  19. Older Amateur Keyboard Players Learning for Self-Fulfilment

    Science.gov (United States)

    Taylor, Angela

    2011-01-01

    This article investigates self-reported music learning experiences of 21 older amateur pianists and electronic keyboard players. Significant changes in their lives and the encouragement of friends were catalysts for returning to or taking up a keyboard instrument as an adult, although not all returners had positive memories of learning a keyboard…

  20. Deploying music characteristics for an affective music player

    NARCIS (Netherlands)

    Zwaag, van der Marjolein D.; Westerink, Joyce H.D.M.; Broek, van den Egon L.; Cohn, Jeffrey; Nijholt, Anton; Pantic, Maja

    2009-01-01

    This paper describes work toward an affective music player (AMP), which is able to direct affect to a goal state by selecting music. Repeatedly, music has been shown to modulate affect; however, precise guidelines for the use of music characteristics in an AMP have not been defined. To explore these

  1. Development of Repeated Sprint Ability in Talented Youth Basketball Players

    NARCIS (Netherlands)

    te Wierike, Sanne C. M.; de Jong, Mark C.; Tromp, Eveline J. Y.; Vuijk, Pieter J.; Lemmink, Koen A. P. M.; Malina, Robert M.; Elferink-Gemser, Marije T.; Visscher, Chris

    2014-01-01

    te Wierike, SCM, de Jong, MC, Tromp, EJY, Vuijk, PJ, Lemmink, KAPM, Malina, RM, Elferink-Gemser, MT, and Visscher, C. Development of repeated sprint ability in talented youth basketball players. J Strength Cond Res 28(4): 928-934, 2014-Factors affecting repeated sprint ability (RSA) were evaluated i

  2. Somatotype of competitive youth soccer players from Brazil.

    Science.gov (United States)

    Fidelix, Yara Lucy; Berria, Juliane; Ferrari, Elisa Pinheiro; Ortiz, Jaelson Gonçalves; Cetolin, Tiago; Petroski, Edio Luiz

    2014-09-29

    The aim of this study was to identify the morphological configuration of youth athletes from professional soccer clubs and to verify their differences according to the tactical position on the field. Overall, 67 male players aged 15 to 17 years were evaluated. The examined anthropometric measurements included body mass, body height, skinfolds (triceps, subscapular, supraspinal and medial calf), girths (flexed and tensed arm and calf) and breadths (humerus and femur). For statistical purposes, analysis of variance and post hoc Bonferroni and Kruskal-Wallis tests were used. We concluded that goalkeepers were heavier and taller than center backs (p = 0.015 and p = 0.001), midfielders (p = 0.005 and p <0.001) and center forward players (p = 0.024 and p <0.001). The average somatotype for defense, forward and goalkeeper positions was a balanced mesomorph. Midfield players showed ectomorphic-mesomorph characteristics. It was concluded that goalkeepers were characterized as being taller and heavier and that somatotype features of athletes were similar between positions, except for midfield players. PMID:25414758

  3. Somatotype of Competitive Youth Soccer Players From Brazil

    Directory of Open Access Journals (Sweden)

    Fidelix Yara Lucy

    2014-10-01

    Full Text Available The aim of this study was to identify the morphological configuration of youth athletes from professional soccer clubs and to verify their differences according to the tactical position on the field. Overall, 67 male players aged 15 to 17 years were evaluated. The examined anthropometric measurements included body mass, body height, skinfolds (triceps, subscapular, supraspinal and medial calf, girths (flexed and tensed arm and calf and breadths (humerus and femur. For statistical purposes, analysis of variance and post hoc Bonferroni and Kruskal-Wallis tests were used. We concluded that goalkeepers were heavier and taller than center backs (p = 0.015 and p = 0.001, midfielders (p = 0.005 and p <0.001 and center forward players (p = 0.024 and p <0.001. The average somatotype for defense, forward and goalkeeper positions was a balanced mesomorph. Midfield players showed ectomorphic-mesomorph characteristics. It was concluded that goalkeepers were characterized as being taller and heavier and that somatotype features of athletes were similar between positions, except for midfield players

  4. Concussion Education for High School Football Players: A Pilot Study

    Science.gov (United States)

    Manasse-Cohick, Nancy J.; Shapley, Kathy L.

    2014-01-01

    This survey study compared high school football players' knowledge and attitudes about concussion before and after receiving concussion education. There were no significant changes in the Concussion Attitude Index. Results revealed a statistically significant difference in the athletes' scores for the Concussion Knowledge Index,…

  5. Teaching Tennis Players To Be Their Own Best Coach.

    Science.gov (United States)

    Ward, Martin J.

    2002-01-01

    Describes how high school and college tennis coaches can prepare their athletes for competitive success, noting factors involved in performance excellence and presenting the BADGE instructional framework, which teaches players that their efforts are the greatest single influence upon future results. The paper explains the importance of positive…

  6. The Development of Attention Skills in Action Video Game Players

    Science.gov (United States)

    Dye, M. W. G.; Green, C. S.; Bavelier, D.

    2009-01-01

    Previous research suggests that action video game play improves attentional resources, allowing gamers to better allocate their attention across both space and time. In order to further characterize the plastic changes resulting from playing these video games, we administered the Attentional Network Test (ANT) to action game players and…

  7. Adaptive Feature Based Control of Compact Disk Players

    DEFF Research Database (Denmark)

    Odgaard, Peter Fogh; Stoustrup, Jakob; Vidal, Enrique Sanchez

    Many have experienced the problem that their Compact Disc players have difficulties playing Compact Discs with surface faults like scratches and fingerprints. The cause of this is due to the two servo control loops used to keep the Optical Pick-up Unit focused and radially on the information track...

  8. Active Player Modeling in the Iterated Prisoner's Dilemma.

    Science.gov (United States)

    Park, Hyunsoo; Kim, Kyung-Joong

    2016-01-01

    The iterated prisoner's dilemma (IPD) is well known within the domain of game theory. Although it is relatively simple, it can also elucidate important problems related to cooperation and trust. Generally, players can predict their opponents' actions when they are able to build a precise model of their behavior based on their game playing experience. However, it is difficult to make such predictions based on a limited number of games. The creation of a precise model requires the use of not only an appropriate learning algorithm and framework but also a good dataset. Active learning approaches have recently been introduced to machine learning communities. The approach can usually produce informative datasets with relatively little effort. Therefore, we have proposed an active modeling technique to predict the behavior of IPD players. The proposed method can model the opponent player's behavior while taking advantage of interactive game environments. This experiment used twelve representative types of players as opponents, and an observer used an active modeling algorithm to model these opponents. This observer actively collected data and modeled the opponent's behavior online. Most of our data showed that the observer was able to build, through direct actions, a more accurate model of an opponent's behavior than when the data were collected through random actions. PMID:26989405

  9. The effects of interset rest on adaptation to 7 weeks of explosive training in young soccer players.

    Science.gov (United States)

    Ramirez-Campillo, Rodrigo; Andrade, David C; Alvarez, Cristian; Henríquez-Olguín, Carlos; Martínez, Cristian; Báez-Sanmartín, Eduardo; Silva-Urra, Juan; Burgos, Carlos; Izquierdo, Mikel

    2014-05-01

    The aim of the study was to compare the effects of plyometric training using 30, 60, or 120 s of rest between sets on explosive adaptations in young soccer players. Four groups of athletes (age 10.4 ± 2.3 y; soccer experience 3.3 ± 1.5 y) were randomly formed: control (CG; n = 15), plyometric training with 30 s (G30; n = 13), 60 s (G60; n = 14), and 120 s (G120; n = 12) of rest between training sets. Before and after intervention players were measured in jump ability, 20-m sprint time, change of direction speed (CODS), and kicking performance. The training program was applied during 7 weeks, 2 sessions per week, for a total of 840 jumps. After intervention the G30, G60 and G120 groups showed a significant (p = 0.0001 - 0.04) and small to moderate effect size (ES) improvement in the countermovement jump (ES = 0.49; 0.58; 0.55), 20 cm drop jump reactive strength index (ES = 0.81; 0.89; 0.86), CODS (ES = -1.03; -0.87; -1.04), and kicking performance (ES = 0.39; 0.49; 0.43), with no differences between treatments. The study shows that 30, 60, and 120 s of rest between sets ensure similar significant and small to moderate ES improvement in jump, CODS, and kicking performance during high-intensity short-term explosive training in young male soccer players. Key pointsReplacing some soccer drills by low volume high-intensity plyometric training would be beneficial in jumping, change of direction speed, and kicking ability in young soccer players.A rest period of 30, 60 or 120 seconds between low-volume high-intensity plyometric sets would induce significant and similar explosive adaptations during a short-term training period in young soccer players.Data from this research can be helpful for soccer trainers in choosing efficient drills and characteristics of between sets recovery programs to enhance performances in young male soccer players. PMID:24790481

  10. Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain.

    Directory of Open Access Journals (Sweden)

    Pranav Danthi

    2008-12-01

    Full Text Available Apoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus outer-capsid protein mu1, which functions to penetrate host cell membranes during viral entry, is the primary regulator of apoptosis following reovirus infection. Ectopic expression of full-length and truncated forms of mu1 indicates that the mu1 phi domain is sufficient to elicit a cell death response. To evaluate the contribution of the mu1 phi domain to the induction of apoptosis following reovirus infection, phi mutant viruses were generated by reverse genetics and analyzed for the capacity to penetrate cell membranes and elicit apoptosis. We found that mutations in phi diminish reovirus membrane penetration efficiency by preventing conformational changes that lead to generation of key reovirus entry intermediates. Independent of effects on membrane penetration, amino acid substitutions in phi affect the apoptotic potential of reovirus, suggesting that phi initiates apoptosis subsequent to cytosolic delivery. In comparison to wild-type virus, apoptosis-defective phi mutant viruses display diminished neurovirulence following intracranial inoculation of newborn mice. These results indicate that the phi domain of mu1 plays an important regulatory role in reovirus-induced apoptosis and disease.

  11. Personality of Elite Male and Female Chess Players and Its Relation to Chess Skill

    Science.gov (United States)

    Vollstadt-Klein, Sabine; Grimm, Oliver; Kirsch, Peter; Bilalic, Merim

    2010-01-01

    Whereas a lot of studies examine cognitive processes in chess players, personality profiles of elite chess players are still not described well. The aim of this study was to examine personality of strong chess experts and its influence on chess skill. We tested elite male and female chess players with Freiburg Personality Inventory Revised…

  12. The role of community in the development of elite handball and football players in Denmark

    DEFF Research Database (Denmark)

    Rossing, Niels Nygaard; Nielsen, André Bjørn; Elbe, A.-M.; Karbing, Dan Stieper

    2016-01-01

    sample of youth players under the age of 12 from 2003, including 147,221 football and 26,290 handball players. Odds ratio analysis showed that both population size and density significantly affected the proportional number of youth players per community and the odds of athletes reaching an elite level in...

  13. Differences in tendon properties in elite badminton players with or without patellar tendinopathy

    DEFF Research Database (Denmark)

    Couppé, C; Kongsgaard, M; Aagaard, P;

    2012-01-01

    The aim of this study was to examine the structural and mechanical properties of the patellar tendon in elite male badminton players with and without patellar tendinopathy. Seven players with unilateral patellar tendinopathy (PT group) on the lead extremity (used for forward lunge) and nine players...

  14. Comparison of Speed, Agility, Anaerobic Strength and Anthropometric Characteristics in Male Football and Futsal Players

    Science.gov (United States)

    Kartal, Resat

    2016-01-01

    The purpose of this study is to compare speed, agility, anaerobic strength and some anthropometric characteristics in male football and futsal players. The sample of the study is composed of male futsal team players of Aydin Adnan Menderes University (19-24 aged) (n = 12) and Aydin Merkez Yeniköy Football Club players (19-24 aged) (n = 12). Within…

  15. Forecasting the Market for New Communication Technology: The Home Video Player Experience.

    Science.gov (United States)

    Klopfenstein, Bruce C.

    This paper describes a critical study of the available forecasts and forecasting studies for the home video player market over a 15-year period which was undertaken to discover why so many forecasts were wrong about consumer adoption of home videocassette players and videodisk players, the reasons for these errors, and ways in which this knowledge…

  16. Self-Esteem Profile among the Female Futsal-Football Players at Jordanian Clubs

    Science.gov (United States)

    Khasawneh, Aman

    2015-01-01

    This study aimed at identifying the level of physical and body self-esteem among the female futsal - football players at Jordanian clubs. The sample of the study was composed of (38) female players among the Jordanian clubs' players of futsal-football who were chosen randomly out of the study community, and the self-esteem scale was used,…

  17. Effect of Core Training on 16 Year-Old Soccer Players

    Science.gov (United States)

    Afyon, Yakup Akif

    2014-01-01

    Core trainings have been widely used by trainers recently in order to improve performance of soccer players. In this context, the aim of this study is to examine the effect of core training on some motoric capabilities of 16 years old soccer players. Thirty certified soccer players who were 16 years old from B.B. Bodrumspor Club in 2013-2014…

  18. 75 FR 4583 - In the Matter of: Certain Electronic Devices, Including Mobile Phones, Portable Music Players...

    Science.gov (United States)

    2010-01-28

    ... COMMISSION In the Matter of: Certain Electronic Devices, Including Mobile Phones, Portable Music Players, and... electronic devices, including mobile phones, portable music players, and computers, by reason of infringement... mobile phones, portable music players, or computers that infringe one or more of claims 1-12 of...

  19. High School Football Players and Their Coaches: A Qualitative Study of Their Relationships

    Science.gov (United States)

    Skaza, Robert J.

    2014-01-01

    This basic qualitative study of high school football coach-player relationships explores the players' perceptions of these relationships, specifically the perceptions the players have of how these relationships influenced their lives. This study allowed the researcher to examine the characteristics of high school football coaches as they relate to…

  20. The Ability of Elite Table Tennis Players with Intellectual Disabilities to Adapt Their Service/Return

    Science.gov (United States)

    Van Biesen, Debbie; Verellen, Joeri; Meyer, Christophe; Mactavish, Jennifer; Van de Vliet, Peter; Vanlandewijck, Yves

    2010-01-01

    In this study the ability of elite table tennis players with intellectual disability (ID) to adapt their service/return to specific ball spin characteristics was investigated. This was done by examining the performance of 39 players with ID and a reference group of 8 players without ID on a standardized table tennis specific test battery. The…

  1. Key concepts in energy

    CERN Document Server

    Madureira, Nuno Luis

    2014-01-01

    Highlights how key energy concepts surfaced, tracing their evolution throughout history to encompasses four economic concepts and four technological-engineering concepts developed through their history to conclude with current economic and environmental sciences Considers the process of energy-substitutions through complementary usages, hybridization and technological mixes Combines a conceptual approach with key theoretical concepts from engineering, geological and economic sciences providing cross disciplinary overview of energy fundamentals in a short and focused reading

  2. Secret Key Crypto Implementations

    Science.gov (United States)

    Bertoni, Guido Marco; Melzani, Filippo

    This chapter presents the algorithm selected in 2001 as the Advanced Encryption Standard. This algorithm is the base for implementing security and privacy based on symmetric key solutions in almost all new applications. Secret key algorithms are used in combination with modes of operation to provide different security properties. The most used modes of operation are presented in this chapter. Finally an overview of the different techniques of software and hardware implementations is given.

  3. Changes of standard physiological-perceptual markers and circulating MicroRNAs in response to tennis match-play: A case report of two elite players

    Directory of Open Access Journals (Sweden)

    Hoppe Matthias Wilhelm

    2016-06-01

    Full Text Available This study aimed to describe the acute changes of both standard physiological-perceptual markers and circulating microRNAs in response to tennis match-play in a detailed case report. Two elite male baseliners with comparable tennis experience were tested for anthropometric and fitness related variables and played 2 h of match-play on a red-clay court. The changes of standard physiological-perceptual markers including the heart rate, lactate concertation, creatine kinase activity, urea concentration and rating of perceived exertion as well as circulating microRNA-133a, -486 and -126 expression rates were examined at 10 different time-points (i.e., pre, during and up to 24 h post match-play. Player 2 had lower fitness related variables, but a higher heart rate, lactate concentration, creatine kinase activity and rating of perceived exertion during play than player 1. Player 2 showed an increase in all microRNAs (≤3.83-fold, most evident post match-play, whereas player 1 demonstrated a decrease (≤0.41-fold. The time-course in the changes of all standard physiological-perceptual markers was similar in both players, whereas this of the microRNAs was different. It was concluded that the relative changes of the circulating microRNA-133a, -486 and 126 expression rates of both players differed in response to tennis match-play with respect to the experienced physiological-perceptual stress and the underlying fitness level. Therefore, circulating microRNAs can serve as additional biomarkers for tennis exercise physiology and may be assessed together with standard markers to conclude whether key cellular regulatory processes were induced in response to match-play.

  4. Arthroscopic isolated posterior labral repair in rugby players

    Directory of Open Access Journals (Sweden)

    Badge Ravi

    2009-01-01

    Full Text Available Background: The shoulder is the second most frequently injured joint after the knee in rugby players and labral tears appear to be common. There is limited data available in the literature regarding the mechanisms of posterior labral injury in rugby players and the management of these injuries. Objective: The aim of this study is to report the clinical presentation, arthroscopic findings, surgical technique for repair, and the functional outcome in elite English rugby players with isolated posterior labral injuries. Study Design: Case series (level IV evidence Materials and m0 ethods: Over a 5-year period we surgically treated 142 elite rugby players, of whom 11 (7.8% had isolated posterior labral injuries.All these 11 patients had significant contact injury. Only three (24% patients had a true posterior shoulder dislocation. Pre- and postoperative assessment included Constant score, Oxford shoulder score, and Oxford instability score. We also assessed the time taken to return to preinjury level of fitness and the complications of surgery. Results: Average follow-up was for 32 months (range 17-54 months. The mean Constant score improved from 66 to 99. The Oxford score indicated improvement, decreasing from 33 to 18; similarly, the Oxford instability score also decreased from 52.2 to 12.3. Return to playing rugby at peak level was at a mean of 4.3 months after arthroscopic repair. Conclusion: Successful clinical results and rapid return to play can be achieved by appropriate early arthroscopic repair and supervised accelerated rehabilitation for posterior labral tears in elite rugby players.

  5. Exosomal Heat Shock Proteins as New Players in Tumour Cell-to-cell Communication

    Directory of Open Access Journals (Sweden)

    Claudia Campanella

    2014-06-01

    Full Text Available Exosomes have recently been proposed as novel elements in the study of intercellular communication in normal and pathological conditions. The biomolecular composition of exosomes reflects the specialized functions of the original cells. Heat shock proteins (Hsps are a group of chaperone proteins with diverse biological roles. In recent years, many studies have focused on the extracellular roles played by Hsps that appear to be involved in cancer development and immune system stimulation. Hsps localized on the surface of exosomes, secreted by normal and tumour cells, could be key players in intercellular cross-talk, particularly during the course of different diseases, such as cancer. Exosomal Hsps offer significant opportunities for clinical applications, including their use as potential novel biomarkers for the diagnoses or prognoses of different diseases, or for therapeutic applications and drug delivery.

  6. Coupling tendencies during exploratory behaviours of competing players in rugby union dyads.

    Science.gov (United States)

    Correia, Vanda; Passos, Pedro; Araújo, Duarte; Davids, Keith; Diniz, Ana; Kelso, J A Scott

    2016-01-01

    This study investigated interpersonal coordination tendencies in 1vs.1 dyads in rugby union, here expressed by participants' movement velocity towards or away from the sideline as they competed to score or prevent a try. We examined whether coupling tendencies of members of each dyad shaped key performance outcomes (try or successful tackle). Data on movement displacement trajectories of eight male rugby union players (aged 11-12 years) were analysed during performance in 47 trials. To assess coordination tendencies during exploratory behaviours in the dyads, analyses of performance time series data were undertaken using variable time graphs, running correlations and cross-correlations. Results revealed distinct coupling patterns characterised by shifts between synchronous coordination and asynchronous coordination tendencies and uncoordinated actions. Observed behaviours were interpreted as attempts of competing participants to create and perceive possibilities for action while seeking to achieve specific performance goals. Findings also revealed that a variety of patterned relations between participants resulted in different performance outcomes. PMID:24814417

  7. Effects of a 12 Week SAQ Training Programme on Agility with and without the Ball among Young Soccer Players.

    Science.gov (United States)

    Milanović, Zoran; Sporiš, Goran; Trajković, Nebojša; James, Nic; Samija, Krešimir

    2013-01-01

    The purpose of this study was to determine the effects of a 12 week conditioning programme involving speed, agility and quickness (SAQ) training and its effect on agility performance in young soccer players. Soccer players were randomly assigned to two groups: experimental group (EG; n = 66, body mass: 71.3 ± 5.9 kg; body height: 1.77 ± 0.07 m) and control group (CG; n = 66, body mass: 70.6 ± 4.9 kg; body height: 1.76 ± 0.06 m). Agility performance was assessed using field tests: Slalom; Slalom with ball; Sprint with 90° turns; Sprint with 90° turns with ball; Sprint with 180° turns; Sprint with backward and forward running; Sprint 4 x 5 m. Statistically significant improvements (p training were evident for almost all measures of agility, with and without the ball, with the exception being the Sprint with backward and forward running. This suggests that SAQ training is an effective way of improving agility, with and without the ball, for young soccer players and can be included in physical conditioning programmes. Key pointsSAQ training appears to be an effective way of improving agility with and without the ball in young soccer playersSoccer coaches could use this training during pre-season and in-season trainingCompared with pre-training, there was a statistically significant improvement in all but one measure of agility, both with and without the ball after SAQ training. PMID:24149731

  8. Apoptosis in irradiated murine tumors.

    Science.gov (United States)

    Stephens, L C; Ang, K K; Schultheiss, T E; Milas, L; Meyn, R E

    1991-09-01

    Early radiation responses of transplantable murine ovarian (OCaI) and hepatocellular (HCaI) carcinomas were examined at 6, 24, 48, 96, and 144 h after single photon doses of 25, 35, or 45 Gy. Previous studies using tumor growth delay and tumor radiocurability assays had shown OCaI tumors to be relatively radiosensitive and HCaI tumors to be radioresistant. At 6 h, approximately 20% of nuclei in OCaI tumors showed aberrations characteristic of cell death by apoptosis. This contrasted to an incidence of 3% in HCaI tumors. Mitotic activity was eliminated in OCaI tumors but was only transiently suppressed in HCaI tumors. At 24-96 h, OCaI tumors continued to display apoptosis and progressive necrosis, whereas HCaI tumors responded by exhibiting marked pleomorphism. Factors other than mitotic activity may influence tumor radiosensitivity, and one of these may be susceptibility to induction of apoptosis (programmed cell death), because this was a prominent early radiation response by the radiosensitive OCaI tumors. PMID:1886987

  9. Comparison of some physical and physiologic properties of soccer players and badminton players of 10-12 years old group

    Directory of Open Access Journals (Sweden)

    Recep Kürkçü

    2009-03-01

    Full Text Available The purpose of this study is aimed to compare some physical characteristics and physiological characteristics of adult footballer and badminton players. The subjects of the study were footballer (18 boys and were badminton players (12 boys who were volunteer at primary school in Şanlıurfa.The volunteers', took part in this study, age, height and the body weight average is determined like this respectively: Footballers: 11,77 ± 0,54 yıl, 151,40 ± 7,35 cm, 41,83 ± 10,27 kgBadminton players: ise11,58 ± 0,66 yıl, 147,37 ± 8,05 cm, 39,08 ± 9,56 kg Systolic and diastolic blood pressure, VC, FVC, FEV1 sit-reach 30 meters sprint and left-right hand gripping strength of subjects were measured. The differences between findings which were obtained by measurements from footballers and badminton players were considered with using "t-test" on SPSS Windows 11. According to the data, differences between age, height, body weight average, diastolic blood pressure VC, FVC, FEV1, sit-reach 30 meters sprint and left hand gripping strength were obtained pointless, in the mean time relaxing heart rate, and sit-reach test (P<0.01, systolic blood pressure and right hand gripping strength values were obtained purposeful on (P<0.05 level. In conclusion, physical and physiological characteristics of footballers and badminton players were affected by their sport branch furthermore, relaxing heart rate, systolic blood pressure, sit -reach 30 meters sprint, right hand gripping strength performance of footballers were obtained preferable.

  10. Comparison of some physical and physiologic properties of soccer players and badminton players of 10-12 years old group

    Directory of Open Access Journals (Sweden)

    Recep Kürkçü

    2009-03-01

    Full Text Available The purpose of this study is aimed to compare some physical characteristics and physiological characteristics of adult footballer and badminton players. The subjects of the study were footballer (18 boys and were badminton players (12 boys who were volunteer at primary school in Şanlıurfa. The volunteers', took part in this study, age, height and the body weight average is determined like this respectively:  Footballers: 11,77 ± 0,54 yıl, 151,40 ± 7,35 cm, 41,83 ± 10,27 kgBadminton players: ise11,58 ± 0,66 yıl, 147,37 ± 8,05 cm, 39,08 ± 9,56 kg    Systolic and diastolic blood pressure, VC, FVC, FEV1 sit-reach 30 meters sprint and left-right hand gripping strength of subjects were measured. The differences between findings which were obtained by measurements from footballers and badminton players were considered with using "t-test" on SPSS Windows 11.     According to the data, differences between age, height, body weight average, diastolic blood pressure VC, FVC, FEV1, sit-reach 30 meters sprint and left hand gripping strength were obtained pointless, in the mean time relaxing heart rate, and sit-reach test (P<0.01, systolic blood pressure and right hand gripping strength values were obtained purposeful on (P<0.05 level.     In conclusion,  physical and physiological characteristics of footballers and badminton players were affected by their sport branch furthermore, relaxing heart rate, systolic blood pressure, sit -reach 30 meters sprint, right hand gripping strength performance of footballers were obtained preferable.

  11. Lock and key colloids.

    Science.gov (United States)

    Sacanna, S; Irvine, W T M; Chaikin, P M; Pine, D J

    2010-03-25

    New functional materials can in principle be created using colloids that self-assemble into a desired structure by means of a programmable recognition and binding scheme. This idea has been explored by attaching 'programmed' DNA strands to nanometre- and micrometre- sized particles and then using DNA hybridization to direct the placement of the particles in the final assembly. Here we demonstrate an alternative recognition mechanism for directing the assembly of composite structures, based on particles with complementary shapes. Our system, which uses Fischer's lock-and-key principle, employs colloidal spheres as keys and monodisperse colloidal particles with a spherical cavity as locks that bind spontaneously and reversibly via the depletion interaction. The lock-and-key binding is specific because it is controlled by how closely the size of a spherical colloidal key particle matches the radius of the spherical cavity of the lock particle. The strength of the binding can be further tuned by adjusting the solution composition or temperature. The composite assemblies have the unique feature of having flexible bonds, allowing us to produce flexible dimeric, trimeric and tetrameric colloidal molecules as well as more complex colloidal polymers. We expect that this lock-and-key recognition mechanism will find wider use as a means of programming and directing colloidal self-assembly. PMID:20336142

  12. ACHIEVEMENT MOTIVATION OF PROFESSIONAL AND AMATEUR SOCCER PLAYERS IN TERMS OF STATUS VARIABLES

    OpenAIRE

    ABAKAY, Uğur; Emin KURU

    2010-01-01

    The purpose of this study was to determine the differences in achievement motivation between the statue variable of being professional and amateur soccer player. The population of this study is created among the active soccer player of 2007-2008 soccer season league teams in Ankara. The sample of the study is consisted from 232 professional and 544 amateur soccer players. The Professional players in the sample of the study are 18-32 aged. The ages of amateur players are changing between 18-33...

  13. Key World Energy Statistics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    The IEA produced its first handy, pocket-sized summary of key energy data in 1997. This new edition responds to the enormously positive reaction to the book since then. Key World Energy Statistics produced by the IEA contains timely, clearly-presented data on supply, transformation and consumption of all major energy sources. The interested businessman, journalist or student will have at his or her fingertips the annual Canadian production of coal, the electricity consumption in Thailand, the price of diesel oil in Spain and thousands of other useful energy facts. It exists in different formats to suit our readers' requirements.

  14. The role of community in the development of elite handball and football players in Denmark.

    Science.gov (United States)

    Rossing, N N; Nielsen, A B; Elbe, A-M; Karbing, D S

    2016-01-01

    The primary purpose of this study was to investigate the effect of the place of early development in a sample of Danish male elite and youth handball and football players. The sample included 366 handball and football players from the elite Danish league in the season 2011-2012 and a comparison sample of youth players under the age of 12 from 2003, including 147,221 football and 26,290 handball players. Odds ratio analysis showed that both population size and density significantly affected the proportional number of youth players per community and the odds of athletes reaching an elite level in football and handball. The odds for youth player registrations in both handball and football increased in rural in contrast to urban communities. However, elite football players primarily came from communities of high density (>1000 pop./km(2)), whereas elite handball players primarily came from less densely populated communities (100 to <250 pop./km(2)). Furthermore, there seems to be a relation between representation of elite and talent clubs in different communities and the probability of becoming an elite player in both sports. The limited number of elite players in both sports from rural communities may be due to national talent development strategies that do not incorporate development support for clubs in rural areas. Additionally, the results of the study clearly suggest the need to include the youth player population to advance research findings in birthplace effect studies. PMID:25703343

  15. Participation motivation and competition anxiety among Korean and non-Korean wheelchair tennis players

    Science.gov (United States)

    Jeong, Irully; Park, Sunghee

    2013-01-01

    The purpose of this study was to examine differences in participation motivation and competition anxiety between Korean and non-Korean wheelchair tennis players and to identify relations between participation motivation and competition anxiety in each group. Sixty-six wheel-chair tennis players who participated in the 2013 Korea Open Wheel-chair Tennis Tournament in Seoul completed the Participation Motivation Survey and the Competitive State Anxiety Inventory II. Data were analyzed by a frequency analysis, descriptive statistics, Pearson’s correlation analysis, and independent samples t-test to identify participants’ demographic characteristics, differences in participation motivation, competition anxiety between Korean and non-Korean players, and correlations between participation motivation and competition anxiety in each group. Korean players reported significantly higher motivation in purification compared to non-Korean players, whereas non-Korean players reported significantly higher motivation in enjoyment. In addition, non-Korean players demonstrated higher cognitive anxiety and self-confidence compared to Korean players. Moreover, the physical anxiety of Korean players was negatively correlated with learning, health-fitness, and enjoyment motivation. On the other hand, only self-confidence was significantly related to learning motivation and enjoyment motivation in non-Korean players. Thus, the results presented herein provide evidence for the development of specialized counseling programs that consider the psychological characteristics of Korean wheelchair tennis players. PMID:24409429

  16. How do clarinet players adjust the resonances of their vocal tracts for different playing effects

    CERN Document Server

    Fritz, C; Fritz, Claudia; Wolfe, Joe

    2005-01-01

    In a simple model, the reed of the clarinet is mechanically loaded by the series combination of the acoustical impedances of the instrument itself and of the player's vocal tract. Here we measure the complex impedance spectrum of players' tracts using an impedance head adapted to fit inside a clarinet mouthpiece. A direct current shunt with high acoustical resistance allows players to blow normally, so the players can simulate the tract condition under playing conditions. The reproducibility of the results suggest that the players' "muscle memory" is reliable for this task. Most players use a single, highly stable vocal tract configuration over most of the playing range, except for the altissimo register. However, this 'normal' configuration varies substantially among musicians. All musicians change the configuration, often drastically for "special effects'' such as glissandi and slurs: the tongue is lowered and the impedance magnitude reduced when the player intends to lower the pitch or to slur downwards, a...

  17. Pedagogical methods for assessing physical performance and functional training players amateur teams

    Directory of Open Access Journals (Sweden)

    Berezka S.M.

    2014-04-01

    Full Text Available Purpose: to determine the optimal level of physical performance and functional training of students - football players. Material : the study involved 19 students - football players. Players performed first running load. Distance of 700-900 m time to overcome a distance of about 5 min. After resting for 5 minutes. performing a second load. Results : the expediency of application of the running version of PWC 170 test to determine the level of physical performance of soccer players. Developed additional criteria for evaluating operational readiness players: speedy recovery index and the index of rapid adaptation to training loads. The indexes of physical fitness, functional training and rapid adaptation of players. Conclusions : pedagogical tests can quickly assess the physical capacity and the willingness of players to competitive activity.

  18. How do clarinet players adjust the resonances of their vocal tracts for different playing effects?

    Science.gov (United States)

    Fritz, Claudia; Wolfe, Joe

    2005-11-01

    In a simple model, the reed of the clarinet is mechanically loaded by the series combination of the acoustical impedances of the instrument itself and of the player's airway. Here we measure the complex impedance spectrum of players' airways using an impedance head adapted to fit inside a clarinet mouthpiece. A direct current shunt with high acoustical resistance allows players to blow normally, so the players can simulate the tract condition under playing conditions. The reproducibility of the results suggest that the players' "muscle memory" is reliable for this task. Most players use a single, highly stable vocal tract configuration over most of the playing range, except for the altissimo register. However, this "normal" configuration varies substantially among musicians. All musicians change the configuration, often drastically for "special effects" such as glissandi and slurs: the tongue is lowered and the impedance magnitude reduced when the player intends to lower the pitch or to slur downwards, and vice versa. PMID:16334701

  19. How do clarinet players adjust the resonances of their vocal tracts for different playing effects?

    Science.gov (United States)

    Fritz, Claudia; Wolfe, Joe

    2005-11-01

    In a simple model, the reed of the clarinet is mechanically loaded by the series combination of the acoustical impedances of the instrument itself and of the player's airway. Here we measure the complex impedance spectrum of players' airways using an impedance head adapted to fit inside a clarinet mouthpiece. A direct current shunt with high acoustical resistance allows players to blow normally, so the players can simulate the tract condition under playing conditions. The reproducibility of the results suggest that the players' ``muscle memory'' is reliable for this task. Most players use a single, highly stable vocal tract configuration over most of the playing range, except for the altissimo register. However, this ``normal'' configuration varies substantially among musicians. All musicians change the configuration, often drastically for ``special effects'' such as glissandi and slurs: the tongue is lowered and the impedance magnitude reduced when the player intends to lower the pitch or to slur downwards, and vice versa.

  20. Five Keys to Success

    Science.gov (United States)

    Peddy, Walter J.

    2009-01-01

    The first year as a principal is filled with self-doubt. As one already knows, there is no book or guide that can fully prepare someone for what the principal's position entails. All first-year principals have to learn by doing. In this article, the author discusses five keys to success that will guide and help first-year principals with the…