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Sample records for aphakia

  1. Aniridia associated with congenital aphakia and secondary glaucoma

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    Moreker Mayur

    2009-01-01

    Full Text Available We report a case of aniridia associated with congenital aphakia and secondary glaucoma. A 35-year-old male presented with aniridia, congenital aphakia and secondary glaucoma in both eyes. After an unsuccessful medical management, he underwent trabeculectomy with mitomycin C and anterior vitrectomy under local anesthesia in his left eye. Postoperatively, at the end of six months, intraocular pressure (IOP in his left eye was controlled without medications. This case highlights the rare association of aniridia with congenital aphakia and secondary glaucoma.

  2. Implantation of iris-claw Artisan intraocular lens for aphakia in Fuchs′ heterochromic iridocyclitis

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    Ahmad Kheirkhah

    2014-01-01

    Full Text Available Implantation of iris-claw Artisan intraocular lens (IOL is a surgical option for correction of aphakia; however, these IOLs have not been used in eyes with uveitis including Fuchs′ heterochromic iridocyclitis (FHI due to possible risk of severe postoperative intraocular inflammation. In the case reported here, we secondarily implanted an Artisan IOL in a 28-year-old man with FHI who had aphakia with no capsular support due to a previous complicated cataract surgery. Enclavation was easily performed and no intraoperative complication was noted. Postoperative course was uneventful with no significant anterior chamber inflammation during 12 months of follow-up. Although there were few deposits on the IOL surface, the patient achieved a best-corrected visual acuity of 20/20 without developing glaucoma or other complications. Therefore, Artisan IOL may be considered for correction of aphakia in patients with FHI. However, studies on large number of patients are required to evaluate safety of the procedure.

  3. The validity of labeled parameters of aphakia-correcting soft contact lenses.

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    Molinari, J F; Semes, L

    1982-08-01

    This study examines the validity of labeled parameters of aphakia-correcting soft contact lenses. The Nikon Projection Lensometer (NPL) and the Hydro-Vue Soft Lens Analyzer (HSLA) were used by two independent inspectors to measure 51 aphakia-correcting lenses. The contact lens power, diameter, and base curve were measured by each of the inspectors and compared to the labeled parameters. All parameter relations that were analyzed revealed that measurements made by the inspectors were not statistically different (p greater than 0.05) from each other and that their combined measurements were not statistically different (p greater than 0.05) from the labeled values. PMID:7137309

  4. A mutation in the FOXE3 gene causes congenital primary aphakia in an autosomal recessive consanguineous Pakistani family

    DEFF Research Database (Denmark)

    Anjum, Iram; Eiberg, Hans; Baig, Shahid Mahmood;

    2010-01-01

    with a clear aphakia phenotype. METHODS: The initial homozygosity screening of the family was extended to all the known autosomal recessive cataract loci in order to exclude the possibility of surgical cataract removal leading to aphakia. The screening was performed using polymorphic nucleotide repeat markers...... known autosomal recessive loci resulted in negative LOD (logarithm of odds) scores. The aphakia phenotype suggested a mutation in FOXE3 close to the AR-locus 1p34.3-p32.2, and sequence analyses revealed the nonsense mutation c.720C>A, changing cysteine 240 to a stop codon. Segregation in the family...

  5. Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice.

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    Wada, Kenta; Matsushima, Yoshibumi; Tada, Tomoki; Hasegawa, Sayaka; Obara, Yo; Yoshizawa, Yasuhiro; Takahashi, Gou; Hiai, Hiroshi; Shimanuki, Midori; Suzuki, Sari; Saitou, Junichi; Yamamoto, Naoki; Ichikawa, Masumi; Watanabe, Kei; Kikkawa, Yoshiaki

    2014-01-01

    Microphthalmia is a severe ocular disorder, and this condition is typically caused by mutations in transcription factors that are involved in eye development. Mice carrying mutations in these transcription factors would be useful tools for defining the mechanisms underlying developmental eye disorders. We discovered a new spontaneous recessive microphthalmos mouse mutant in the Japanese wild-derived inbred strain KOR1/Stm. The homozygous mutant mice were histologically characterized as microphthalmic by the absence of crystallin in the lens, a condition referred to as aphakia. By positional cloning, we identified the nonsense mutation c.444C>A outside the genomic region that encodes the homeodomain of the paired-like homeodomain transcription factor 3 gene (Pitx3) as the mutation responsible for the microphthalmia and aphakia. We examined Pitx3 mRNA expression of mutant mice during embryonic stages using RT-PCR and found that the expression levels are higher than in wild-type mice. Pitx3 over-expression in the lens during developmental stages was also confirmed at the protein level in the microphthalmos mutants via immunohistochemical analyses. Although lens fiber differentiation was not observed in the mutants, strong PITX3 protein signals were observed in the lens vesicles of the mutant lens. Thus, we speculated that abnormal PITX3, which lacks the C-terminus (including the OAR domain) as a result of the nonsense mutation, is expressed in mutant lenses. We showed that the expression of the downstream genes Foxe3, Prox1, and Mip was altered because of the Pitx3 mutation, with large reductions in the lens vesicles in the mutants. Similar profiles were observed by immunohistochemical analysis of these proteins. The expression profiles of crystallins were also altered in the mutants. Therefore, we speculated that the microphthalmos/aphakia in this mutant is caused by the expression of truncated PITX3, resulting in the abnormal expression of downstream targets and

  6. Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice.

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    Kenta Wada

    Full Text Available Microphthalmia is a severe ocular disorder, and this condition is typically caused by mutations in transcription factors that are involved in eye development. Mice carrying mutations in these transcription factors would be useful tools for defining the mechanisms underlying developmental eye disorders. We discovered a new spontaneous recessive microphthalmos mouse mutant in the Japanese wild-derived inbred strain KOR1/Stm. The homozygous mutant mice were histologically characterized as microphthalmic by the absence of crystallin in the lens, a condition referred to as aphakia. By positional cloning, we identified the nonsense mutation c.444C>A outside the genomic region that encodes the homeodomain of the paired-like homeodomain transcription factor 3 gene (Pitx3 as the mutation responsible for the microphthalmia and aphakia. We examined Pitx3 mRNA expression of mutant mice during embryonic stages using RT-PCR and found that the expression levels are higher than in wild-type mice. Pitx3 over-expression in the lens during developmental stages was also confirmed at the protein level in the microphthalmos mutants via immunohistochemical analyses. Although lens fiber differentiation was not observed in the mutants, strong PITX3 protein signals were observed in the lens vesicles of the mutant lens. Thus, we speculated that abnormal PITX3, which lacks the C-terminus (including the OAR domain as a result of the nonsense mutation, is expressed in mutant lenses. We showed that the expression of the downstream genes Foxe3, Prox1, and Mip was altered because of the Pitx3 mutation, with large reductions in the lens vesicles in the mutants. Similar profiles were observed by immunohistochemical analysis of these proteins. The expression profiles of crystallins were also altered in the mutants. Therefore, we speculated that the microphthalmos/aphakia in this mutant is caused by the expression of truncated PITX3, resulting in the abnormal expression of

  7. Anterior Chamber Iris Claw Lens for the Treatment of Aphakia in a Patient with Megalocornea

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    Saffra, Norman; Rakhamimov, Aleksandr; Masini, Robert; Rosenthal, Kenneth J.

    2015-01-01

    Megalocornea in isolation is a rare congenital enlargement of the cornea greater than 13 mm in diameter. Patients with megalocornea are prone to cataract formation, crystalline lens subluxation, zonular deficiencies and dislocation of the posterior chamber intraocular lens (PCIOL) within the capsular bag. A 55-year-old male with megalocornea in isolation developed subluxation of the capsular bag and PCIOL. The PCIOL and capsular bag were explanted, and the patient was subsequently implanted with an anterior chamber iris claw lens. An anterior chamber iris claw lens is an effective option for the correction of aphakia in patients with megalocornea. PMID:26120314

  8. Bilateral microphthalmia and aphakia associated with multiple eye abnormalities in a free-living European red deer calf (Cervus elaphus).

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    Mutinelli, Franco; Vercelli, Antonella; Carminato, Antonio; Luchesa, Lucio; Pasolli, Claudio; Cova, Mariapia; Marchioro, Wendy; Melchiotti, Erica; Vascellari, Marta

    2012-04-01

    A free-living European red deer calf (Cervus elaphus) was euthanized due to bilateral microphthalmia. Lens was missing, replaced by proliferating squamous epithelial cells; hyperplastic squamous cells, sebaceous and mucinous glands were observed within the cornea with the characteristics of inclusion cyst. Findings were consistent with congenital microphthalmia/aphakia, with multiple eye abnormalities.

  9. Cataract, ocular surgery, aphakia, and the chromatic expression of the painter Jovan Bijelić

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    Nikolić Ljubiša

    2016-01-01

    Full Text Available Background/Aim. Approaching art from the standpoint of optics and the artist’s eye pathology can sometimes explain the shift of the spectral colors in the work of some artists with cataract and aphakia. This may not be obvious in the paintings of other artists with the same eye pathology. The aim of this study was to create a timeline from the recently obtained details of the cataract surgery, his best corrected aphakic visual acuity, and the last paintings of the artist Jovan Bijelić. Methods. The research included primary and secondary source material: Bijelić’s paintings from all stages of his career, interviews with Bijelić and his eye surgeon, art criticism, sources with the description of Bijelić’s symptoms, hospital archives, discussion with art historians, comparison of his palette from different periods. Results. Jovan Bijelić was nearly blind from cataract in 1957. He underwent an unsuccessful cataract surgery in 1956, followed by enucleation of the operated eye. In 1958, 20/25–20/20 vision was regained, after the extracapsular cataract extraction and sector iridectomy in his right eye, with the posterior lens capsule discision afterwards. Xanthopsia and cyanopsia are not present in his art, which is not a representation of visualized objects. Conclusion. The response of Jovan Bijelić to cataract and aphakia was predominantly a change of his style.

  10. Aphakia correction with retropupillary fixated iris-claw lens (Artisan – long-term results

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    Schallenberg M

    2013-12-01

    Full Text Available Maurice Schallenberg,1,2 Dirk Dekowski,1 Angela Hahn,1 Thomas Laube,1,3 Klaus-Peter Steuhl,1 Daniel Meller11Department of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; 2HELIOS Klinikum Wuppertal, Wuppertal, Germany; 3Zentrum für Augenheilkunde PD Dr Laube, Düsseldorf, GermanyPurpose: To evaluate the technique, safety, and efficacy of the retropupillary implantation of iris-claw intraocular lenses in a long-term follow-up study.Patients and methods: This retrospective study included 31 eyes of 31 patients who underwent an Artisan aphakic intraocular lens implantation between January 2006 and February 2011 at the University Hospital Essen, Essen, Germany and at the Zentrum für Augenheilkunde PD Dr Laube, Düsseldorf, Germany. Preoperative data collected included demographics, etiology of aphakia, previous surgeries, preoperative eye pathology, intraocular pressure, clinical signs of endothelial cell loss, and best corrected visual acuity. Operative data and postoperative outcomes included the best corrected visual acuity, lens position, intraocular pressure, pigment dispersion, clinical signs of endothelial cell loss, development of macular edema, and other complications.Results: Thirty-one patients were included. The mean follow-up was 25.2 months (range: 4–48 months. The mean best corrected visual acuity postoperatively was 0.64 logarithm of the minimum angle of resolution (logMAR and varied from 0 logMAR to 3 logMAR. Some patients had a low visual acuity preoperatively because of preoperative eye pathologies. In 22 patients the visual acuity improved, in two patients the visual acuity remained unchanged, and seven patients showed a decreased visual acuity. Complications were peaked pupils (n=10 and retinal detachment in one case. Four patients showed an iris atrophy and high intraocular pressure was observed only in one patient. Subluxation of the intraocular lens, endothelial cell loss, and

  11. Transpupillary Argon Laser Cyclophotocoagulation in a Refractory Traumatic Glaucoma Patient with Aphakia and Aniridia

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    Umut Duygu Uzunel

    2016-01-01

    Full Text Available We present a case of transpupillary argon laser cyclophotocoagulation (TALC in a patient with traumatic aniridia and aphakia secondary to blunt trauma who had previous bilateral trabeculectomy. Four months after the trauma the patient’s intraocular pressure (IOP rose to 35 mmHg despite topical antiglaucomatous medication. Inferior 180 degrees cyclophotocoagulation was performed with transpupillary argon laser in the first session and his IOP fell to values of 12-17 mmHg. Twelve weeks after TALC, his IOP rose to 22 mmHg and we had to apply TALC to the residual ciliary processes. Seven months later his IOP was 13 mmHg with topical dorzolamide/timolol and latanoprost administration. TALC may be an effective treatment alternative for lowering IOP in patients with visible ciliary processes who do not respond to conventional medical or laser treatment.

  12. [Interaction of the mutant aphakia, fidget and ocular retardation genes in mice].

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    Koniukhov, B V; Nonchev, S G

    1982-07-01

    The phenogenetic analysis of the effects of aphakia (ak) gene and its interaction with the ocular retardation (or) and fidget (fi) genes suggests that the ak gene acts in the lens cells with the result of arresting lens fibre differentiation. In mice homozygous for ak, the lens failure leads to secondary retina defects, in particular, to formation of retinal folds. In ak/ak or/or mice, the lens and retina morphogenesis stops at the optic cup stage, the eye is strongly reduced in size and more affected, compared to the corresponding single homozygotes. Unlike ak/ak or/or, in the ak/ak fi/fi mice the eyes are more regular in shape than those in the ak/ak +/+ condition. The fi gene inhibition of the retina anlage growth leads to some improvement of the eye development in double ak/ak fi/fi homozygotes, due to the absence of extensive retina folding.

  13. Retropupillary iris claw intraocular lens implantation in aphakia for dislocated intraocular lens

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    Faria MY

    2016-08-01

    twelve patients, 4 subluxation of the IOL was observed in one patient, and 5 macular edema was found in three eyes.Conclusion: The results demonstrate that retropupillary ICIOL is an easy and effective method for the correction of aphakia in patients not receiving capsule support. The safety of this procedure must be interpreted in the context of a surgery usually indicated in complicated cases. Keywords: aphakia, retropupillary iris claw IOL, dislocated IOL

  14. Endoscopic-Assisted Scleral Fixated IOL in the Management of Secondary Aphakia in Children

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    Heba A. El Gendy

    2016-01-01

    Full Text Available Purpose. To evaluate the short-term postoperative outcomes in endoscopic-assisted sclera fixation intraocular lens (IOL for the management of secondary aphakia in children. Methods. This is a prospective study, whereas 40 aphakic eyes with absence of a good capsular support were implanted by endoscopy-assisted sclera fixation technique. Results. No major intraoperative complications were recorded. All cases were followed up for 6 months. Only transient ocular hypertension occurred in 10 (25% eyes. Lens decentration and/or tilting were clinically detected in 2 eyes (5%. Ultrasonic biomicroscopic (UBM examination revealed lens tilting in 2 (5% of the operated eyes, despite the proper haptics positioning in the ciliary sulcus. Postoperative vitreous hemorrhage was reported in 5 eyes (12.5% in the early postoperative period and retinal detachment in one eye. A postoperative refractive astigmatism ranging from 0.75 D to 3.75 D (mean 1.7 D ± 0.79 was recorded, as compared to mean preoperative values of 2.00 D, with no statistically significant differences being recorded (p≥0.05. An improvement of BCVA, 1-2 lines on Snellen chart at the end of the follow-up period, was detected in 23 eyes (57.5% with a mean of 0.6±0.08 SD, as compared to a preoperative mean values of 0.5±0.07 SD (p≥0.05. Conclusion. Using an endoscope for transscleral suturing of intraocular lenses in aphakic pediatric eyes might be considered as being an effective technique that can reduce surgical complications, especially postoperative lens decentration.

  15. Endoscopic-Assisted Scleral Fixated IOL in the Management of Secondary Aphakia in Children

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    Khalil, Hossam Eldin; Haroun, Hazem Effat; El Deeb, Mohamed Wagieh

    2016-01-01

    Purpose. To evaluate the short-term postoperative outcomes in endoscopic-assisted sclera fixation intraocular lens (IOL) for the management of secondary aphakia in children. Methods. This is a prospective study, whereas 40 aphakic eyes with absence of a good capsular support were implanted by endoscopy-assisted sclera fixation technique. Results. No major intraoperative complications were recorded. All cases were followed up for 6 months. Only transient ocular hypertension occurred in 10 (25%) eyes. Lens decentration and/or tilting were clinically detected in 2 eyes (5%). Ultrasonic biomicroscopic (UBM) examination revealed lens tilting in 2 (5%) of the operated eyes, despite the proper haptics positioning in the ciliary sulcus. Postoperative vitreous hemorrhage was reported in 5 eyes (12.5%) in the early postoperative period and retinal detachment in one eye. A postoperative refractive astigmatism ranging from 0.75 D to 3.75 D (mean 1.7 D ± 0.79) was recorded, as compared to mean preoperative values of 2.00 D, with no statistically significant differences being recorded (p ≥ 0.05). An improvement of BCVA, 1-2 lines on Snellen chart at the end of the follow-up period, was detected in 23 eyes (57.5%) with a mean of 0.6 ± 0.08 SD, as compared to a preoperative mean values of 0.5 ± 0.07 SD (p ≥ 0.05). Conclusion. Using an endoscope for transscleral suturing of intraocular lenses in aphakic pediatric eyes might be considered as being an effective technique that can reduce surgical complications, especially postoperative lens decentration. PMID:27595016

  16. Retropupillary iris claw intraocular lens implantation in aphakia for dislocated intraocular lens

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    Faria, Mun Yueh; Ferreira, Nuno Pinto; Pinto, Joana Medeiros; Sousa, David Cordeiro; Leal, Ines; Neto, Eliana; Marques-Neves, Carlos

    2016-01-01

    Background Nowadays, dislocated intraocular lenses (IOLs) and inadequate capsular support are becoming a challenge for every ophthalmic surgeon. Explantation of dislocated IOL and iris claw IOL (ICIOL) are the techniques that have been used in our ophthalmic department. The aim of this study is to report our technique for retropupillar ICIOL. Methods This study is a retrospective case series. A total of 105 eyes with dislocated IOL from the patients at the Department of Ophthalmology in Santa Maria Hospital, a tertiary reference hospital in Lisbon, Portugal, from January 2012 until January 2016, had been analyzed. Of these 105 eyes, 66 eyes had dislocated one-piece IOL and 39 eyes had dislocated three-piece IOL. The latter underwent iris suture of the same IOL and were excluded from this study. The remaining 66 eyes with dislocated one-piece IOL underwent pars plana vitrectomy, that is, explantation of dislocated IOL through corneal incision and an implantation of retropupillary ICIOL. Operative data and postoperative outcomes included best corrected visual acuity, IOL position, intraocular pressure, pigment dispersion, clinical signs of endothelial cell loss, and anterior chamber depth. Results The mean follow-up was 23 months (range: 6–48 months). The mean preoperative best corrected visual acuity was 1.260±0.771 logMAR, and postoperative best corrected visual acuity was 0.352±0.400 logMAR units. Mean vision gain was 0.909 logMar units. The patients had the following complications: 1) retinal detachment was found in one patient, 2) corneal edema was found in three patients, 3) high intraocular pressure was observed in twelve patients, 4) subluxation of the IOL was observed in one patient, and 5) macular edema was found in three eyes. Conclusion The results demonstrate that retropupillary ICIOL is an easy and effective method for the correction of aphakia in patients not receiving capsule support. The safety of this procedure must be interpreted in the context

  17. Homozygous FOXE3 mutations cause non-syndromic, bilateral, total sclerocornea, aphakia, microphthalmia and optic disc coloboma

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    Buentello-Volante, Beatriz; McKibbin, Martin; Rocha-Medina, J. Alberto; Fernandez-Fuentes, Narcis; Koga-Nakamura, Wilson; Ashiq, Aruna; Khan, Kamron; Booth, Adam P.; Williams, Grange; Raashid, Yasmin; Jafri, Hussain; Rice, Aine; Inglehearn, Chris F.; Zenteno, Juan Carlos

    2010-01-01

    Purpose To investigate the genetic basis of recessively-inherited congenital, non syndromic, bilateral, total sclerocornea in two consanguineous pedigrees, one from the Punjab province of Pakistan and the other from the Tlaxcala province of Mexico. Methods Ophthalmic examinations were conducted on each family member to confirm their diagnosis and magnetic resonance imaging (MRI) or ultrasonography of the eyes was performed on some family members. Genomic DNA was analyzed by homozygosity mapping using the Affymetrix 6.0 SNP array and linkage was confirmed with polymorphic microsatellite markers. Candidate genes were sequenced. Results A diagnosis of autosomal recessive sclerocornea was established for 7 members of the Pakistani and 8 members of the Mexican pedigrees. In the Pakistani family we established linkage to a region on chromosome 1p that contained Forkhead Box E3 (FOXE3), a strong candidate gene since FOXE3 mutations had previously been associated with various anterior segment abnormalities. Sequencing FOXE3 identified the previously reported nonsense mutation, c.720C>A, p.C240X, in the Pakistani pedigree and a novel missense mutation which disrupts an evolutionarily conserved residue in the forkhead domain, c.292T>C, p.Y98H, in the Mexican pedigree. Individuals with heterozygous mutations had no ocular abnormalities. MRI or ultrasonography confirmed that the patients with sclerocornea were also aphakic, had microphthalmia and some had optic disc coloboma. Conclusions This is the fourth report detailing homozygous FOXE3 mutations causing anterior segment abnormalities in human patients. Previous papers have emphasized aphakia and microphthalmia as the primary phenotype, but we find that the initial diagnosis – and perhaps the only one possible in a rural setting – is one of non-syndromic, bilateral, total sclerocornea. Dominantly inherited anterior segment defects have also been noted in association with heterozygous FOXE3 mutations. However the absence

  18. 先天性白内障术后无晶状体眼RGPCL矫正的临床效果观察%Clinical effects of infants aphakia corrected by rigid gas permeable contact lens after congenital cataract surgery

    Institute of Scientific and Technical Information of China (English)

    周建兰; 谢培英; 王丹; 常勇; 刘营

    2015-01-01

    目的:探讨硬性透气性接触镜(CRGPCL)在先天性白内障患儿术后无晶体眼的视力矫正及视功能改善的临床效果。方法回顾性分析2010年5月至2012年10月7例先天性白内障术后无晶体眼的患儿验配Meni-con ZRGPCL,并观察戴镜后1个月、3个月、6个月、1年的戴镜视力及视功能提高的情况。结果1年观察期内均未出现严重的并发症而导致停戴。所有患儿配戴RGPCL1年时矫正视力均较框架镜矫正有提高,双眼视功能检查有部分改善。结论 RGPCL为先天性白内障术后无晶体眼的患儿在视力提高及视功能改善方面提供了一个良好的矫正方式,规范配戴与定期复查也同时降低了戴镜风险。%Objective To investigate clinic effects of corrected visual acuity and visual function using by Rigid Gas Permeable Contact lens(RGPCL) in infant aphakia after Cataract surgery. Methods A retrospective analysis of 7 cases infants aphakia who fitted Menicon Z RGPCL in our center. We inspected the corrected visual acuity and visual function during periods of wearing RGPCL 1m,3m,6m and 1y. Results All children’s RGPCL corrected visual acuity and partial visual function were improved at 1st year. With the schedule of parents lens care, standard lens wearing,regular lens check and amblyopia training,there were no serious applications in 7 cases. Conclusions Infants aphakia corrected by RGPCL after Cataract surgery which obtains good corrected visual acuity and visual function and standard lens wearing and regular lens check reduce risks of lens use.

  19. Sulcus fixated foldable intraocular lens implanted by injector in aphakia after vitrectomy%玻璃体切除术后无晶状体眼悬吊式折叠人工晶状体推注植入术

    Institute of Scientific and Technical Information of China (English)

    翁晓春

    2014-01-01

    Objective To evaluate the clinical effect of sulcus fixated foldable intraocular lens implanted by injector in aphakia after vitrectomy.Methods 31 eyes of 31 cases of aphakia after vitrectomy were treated by sulcus fixated foldable intraocular lens implanted by injector.The surgery was performed under stable irrigation and the incision was made at upper limbus.The suspensory suture was placed at 2 o' clock and 8 o' clock.Then the foldable intraocular lens implanted by injector was sutured and localized at ciliary sulcus.Results The surgery was successfully performed in 30 cases and failed in 1 case due to small amount sub choroidal expulsive hemorrhage.Of these 30 cases,the intraocular lens was centered and the intraocular pressure was normal.The surgical complications included retinal detachment in 1 cases at 2 weeks postoperatively which were treated by vitrectomy,and intraocular lens dislocation in 1 case at 6 months postoperatively which was reset by operation.The visual acuities of 31 cases achieved expected visual acuity.Conclusion Sulcus fixated foldable intraocular lens implanted by injector in aphakia eye after vitrectomy has small incision,which minimizes surgery induced astigmatism,and avoid the risk of intraoperative hypotension.%目的 探讨玻璃体切除术后无晶状体眼悬吊式折叠人工晶状体推注器植入术的效果.方法 31例(31眼)建立灌注后,做上方角巩膜隧道切口,8点、2点位予置悬吊线并引出切口外.折叠式人工晶状体装入推注器后推至晶状体袢稍露出,8点位悬吊线打结于晶状体袢.推注器进入前房后植入人工晶状体.末端晶体袢露出隧道切口外,2点位悬吊线打结于另一袢并送入前房,再调整到后房正位后固定悬吊线.结果 30例手术顺利.术后人工晶状体正位.眼压正常,术中1例发生脉络膜下少量出血.术后6个月1例发生人工晶状体脱位再次手术正位,1例术后2周发生视网膜脱离,

  20. 小切口人工晶状体睫状沟悬吊术在玻璃体切割术后无晶状体囊膜眼应用%Application of intraocular lens implantation with suture fixation at ciliary sulcus in aphakia after vitrectomy through small incision

    Institute of Scientific and Technical Information of China (English)

    韩非; 吴燕; 段烈英; 刘恒; 罗涛; 蒋炜

    2012-01-01

    Objective To investigate the application of intraocular lens implantation with suture fixation at ciliary sulcus in aphakia after vitrectomy through small incision.Methods Intraocular lens implantation with suture fixation at ciliary sulcus was performed in 25 patients of aphakia and without capsule after vitrectomy.All the cases were followed up 1-6 months postoperatively.Results The visual acuity of all operated eyes was better than or equal to that of pre-operative eyes.No severe complication was found.Conclusions Intraocular lens implantation with suture fixation at ciliary sulcus through small incision is an effective method to aphakia after vitrectomy.%目的 探讨小切口人工晶状体睫状沟悬吊术在玻璃体切割术后无晶状体囊膜眼中的应用情况.方法 在球后 、表面麻醉下给25例(25只眼)玻璃体切割术后无晶状体且无囊膜眼行角膜缘小切口人工晶状体睫状沟悬吊术.术后随访1~6月.结果 25只眼术后视力均达到或超过术前矫正视力,无严重并发症.结论 小切口人工晶状体睫状沟悬吊术治疗玻璃体切割术后无晶状体囊膜眼的效果确切.

  1. 软性虹彩片联合透气性半硬性角膜接触镜矫治外伤性无虹膜无晶状体眼%Soft cosmetic contact lens combined with half-rigid gas permeable contact lens for traumatic aniridia and aphakia

    Institute of Scientific and Technical Information of China (English)

    刘立洲; 吕燕云; 彭丽

    2011-01-01

    目的 评价软性虹彩片联合透气性半硬性角膜接触镜(RGPCL)对外伤性无虹膜无晶状体眼的矫治效果.设计回顾性病例系列.研究对象 角膜内皮细胞密度在2500个/mm2以上外伤性无虹膜无晶状体眼患者59例(59眼).方法患者联合戴用软性虹彩片和RGPCL,比较初诊时的插片视力和RGPCL矫正视力,随诊5年,非接触性角膜内皮计数仪检测角膜内皮细胞改变情况及裂隙灯下检查角结膜并发症情况.主要指标矫正视力,角膜内皮细胞计数,角结膜并发症.结果 外伤性无虹膜无晶状体眼配戴软性虹彩片联合RGPCL的平均矫正视力(0.64±0.23)明显高于初诊时的插片视力(0.33±0.21),差异有统计学意义(t=7.750,P=0.000);畏光症状减轻;初诊时平均角膜内皮细胞计数为(2695.5±125.4)个/mm2(n=59),戴镜1、2、3、4、5年分别平均为(2705.4±145.6)个/mm2(n=43),(2639.5±146.7)个/mm2(n=30),(2625.5±143.6)个/mm2(n=26),(2641.5±168.5)个/mm2(n=32),(2638.2±128.6)个/mm2(n=29),第5年与初诊相比平均减少(70.3±8.7)个/mm2.角膜、结膜未见严重并发症.结论 软性虹彩片联合RGPCL对角膜内皮细胞密度在2500个/mm2以上的外伤性无虹膜无晶状体眼在提高视力和解决畏光方面是一种有效方法,但要定期复查角结膜情况.%Objective To investigate the clinical effects of soft cosmetic contact lens combined with half-rigid gas permeable contact lens (RGPCL) for traumatic aniridia and aphakia. Design Retrospective case series. Participants 59 patients (59 eyes) with traumatic aniridia and aphakia,whose corneal endothelial cell density was above 2500 cells/mm2. Methods 59 patients (59 eyes) fitted with soft cosmetic contact lens combined with RGPCL were followed up for 5 years. The corrected visual acuity was compared between contact lens group and glasses group. The corneal endothelial changes were observed. The complications in cornea and conjunctiva were observed using slit

  2. Comparison of effects of secondary in-the-bag and sulcus intraocular lens implantation in pediatric aphakia after congenital cataract operation%Ⅱ期囊袋内和睫状沟人工晶状体植入矫正儿童先天性白内障术后无晶状体眼的疗效比较

    Institute of Scientific and Technical Information of China (English)

    祝雪宁; 喻芳; 邢潇英; 赵云娥; 宫贤惠; 李瑾

    2013-01-01

    入和睫状沟植入在术后视力和并发症方面无明显差异.%Objective To compare the results of secondary in-the-bag intraocular lens (IOL) implantation with secondary sulcus IOL implantation in the eyes which received cataract extraction during early infancy.Methods A case control study.We selected 60 eyes of 44 patients with pediatric aphakia that meet the inclusion criterion in Affiliated Eye Hospital of Wenzhou Medical College from September 2005 to August,2011.Thirty eyes received in-the-bag secondary IOL implantation and were compared with 30 eyes that received secondary sulcus IOL implantation.Data were collected for the ages at cataract extraction and at secondary IOL implantation,the preoperative axial length,the length of follow-up,postoperative complications,postoperative best-corrected visual acuity (BCVA) and refraction.When sufficient capsular opening was possible or capsular support deemed adequate,an IOL was placed within the capsular bag,otherwise the IOL was implanted in the sulcus.The x2 test or Fisher exact test was used to compare complications between the in-the-bag and sulcus groups.The independent-samples t test or Wilcoxon rank sum test was used to compare demographic,preoperative and postoperative refractive relevant data between the in-the-bag and sulcus groups.Results The median of 1-week-postoperative spherical equivalent clustered 1.00 D (range,-2.13 to 3.38 D) for in-the-bag group and 0.69 D (range,-2.25 to 2.38 D) for the sulcus group (Z =-1.01,P =0.31).The median of 1-year-postoperative spherical equivalent clustered 0.00 D (range,-3.50 to 3.00 D) for in-the-bag and-0.50 D (range,-3.25 to 2.50 D) for the sulcus (Z =-0.53,P =0.60).The last follow-up BCVA was available in 23 of 30 eyes in the in-the-bag group and 22 of 30 eyes in the sulcus group.The median of visual outcome clustered around 0.20 D (range,0.05 to 0.70 D) for in-the-bag and 0.20 D (range,0.05 to 0.60 D) for the sulcus (Z =-1.06,P =0.29).The rate of nystagmus

  3. Motor Deficits and Altered Striatal Gene Expression in aphakia(ak) Mice

    OpenAIRE

    Singh, Bhupinder; Wilson, Jean H.; Vasavada, Hema H; Guo, Zhenchao; Allore, Heather G.; Zeiss, Caroline J.

    2007-01-01

    Like humans with Parkinsons disease (PD), the ak mouse lacks the majority of the substantia nigra pars compacta (SNc) and experiences striatal denervation. The purpose of this study was to test whether motor abnormalities in the ak mouse progress over time, and whether motor function could be associated with temporal alterations in the striatal transcriptome. Ak and wt mice (28 to 180 days old) were tested using paradigms sensitive to nigrostriatal dysfunction. Results were analyzed using a l...

  4. Pars plana vitrectomy and artisan iris fixated intraocular lens for aphakia in complicated vitreoretinal referrals

    Institute of Scientific and Technical Information of China (English)

    Lolly Pattnaik; Kusai Almozawak; Susanne Binder

    2013-01-01

    Objective:To evaluate postoperative outcome of cases undergoingArtisan aphakic iris fixated intraocular lens implantation(IOL) in complicated vitreoretinal referrals, atOutpatientDepartment ofOphthalmology,RudolfFoundationClinic,Vienna,Austria.Methods:It was a retrospective interventional case series involving24 patients who have undergone pars plana vitrectomy(PPV) with theArtisan iris fixated lens implantation procedure.Herein, procedures, preoperative corrected distance visual acuity(CDVA), causes of referral, post-operativeCDVA and clinical complications were recorded.Results:The mean age of24 patients(17 males and7 females) was(69.88±14.50), with the range32-83 years.The mean preoperative visual acuity was(1.40±0.83) with the range0.46-3.00 logMAR units.After a mean follow up period for(3.12±2.54) with the range1-12 months, the meanCDVA at the last follow-up was(0.95±0.84) logMAR units with the range0.097-3.000 logMAR units.Complicated cataract surgery was the most common cause for referral with the value,54.21% among cases,n=13.Secondary glaucoma was the commonest postoperative complication25.00% withn=6.The other complications included were transient hypotony(n=3;12.51%), hyphaema(n=2;8.34%), corneal oedema(n=1;4.17%), corneal erosion (n=1;4.17%), vitreous haemorrhage(n=2;8.34%) and oval pupil(n=1;4.17%).Pairedt test result showed no significant difference between preoperative and postoperative visual acuities(P>0.05). Conclusions:Artisan iris fixatedIOL’s are a safe and effective option in eyes with concomitant poor capsular support and vitreoretinal complications requiringPPV.The postoperative visual acuity depends on the underlying pathological features present preoperatively.

  5. Pars plana vitrectomy and artisan iris fixated intraocular lens for aphakia in complicated vitreoretinal referrals

    Directory of Open Access Journals (Sweden)

    Lolly Pattnaik

    2013-01-01

    Conclusions: Artisan iris fixated IOL's are a safe and effective option in eyes with concomitant poor capsular support and vitreoretinal complications requiring PPV. The postoperative visual acuity depends on the underlying pathological features present preoperatively.

  6. Homozygous FOXE3 mutations cause non-syndromic, bilateral, total sclerocornea, aphakia, microphthalmia and optic disc coloboma

    OpenAIRE

    Ali, Manir; Buentello-Volante, Beatriz; McKibbin, Martin; Rocha-Medina, J. Alberto; Fernandez-Fuentes, Narcis; Koga-Nakamura, Wilson; Ashiq, Aruna; Khan, Kamron; Booth, Adam P.; Williams, Grange; Raashid, Yasmin; Jafri, Hussain; Rice, Aine; Inglehearn, Chris F.; Zenteno, Juan Carlos

    2010-01-01

    Purpose To investigate the genetic basis of recessively-inherited congenital, non syndromic, bilateral, total sclerocornea in two consanguineous pedigrees, one from the Punjab province of Pakistan and the other from the Tlaxcala province of Mexico. Methods Ophthalmic examinations were conducted on each family member to confirm their diagnosis and magnetic resonance imaging (MRI) or ultrasonography of the eyes was performed on some family members. Genomic DNA was analyzed by homozygosity mappi...

  7. 无晶状体眼角膜接触镜的配戴%Treatment of the aphakia with contact lens

    Institute of Scientific and Technical Information of China (English)

    郭锐

    2006-01-01

    我们对无晶状体眼患者所存在的问题,特点,及所需要的矫正治疗进行了综合分析.我们发现角膜接触镜对于无晶状体眼患者的矫正有很大的帮助,较之其他的矫正方法存在着独特的优势.本文着重从无晶状体眼患者角膜接触镜矫正治疗的方式选择,角膜接触镜的设计以及所产生的并发症等方面进行了阐述.

  8. 虹膜型人工晶状体治疗外伤性无虹膜无晶状体眼%Black-diaphragm intraocular lens implantation in management of traumatic aniridia combined with aphakia

    Institute of Scientific and Technical Information of China (English)

    秦桂霞; 刘惠

    2006-01-01

    目的探讨虹膜型人工晶状体对外伤性无虹膜无晶状体眼的治疗作用.方法观察31例(31眼)虹膜型人工晶状体植入术后的视力情况及并发症.结果术后患者视力有不同程度提高,畏光症状明显改善.结论虹膜型人工晶状体对治疗外伤性无虹膜无晶状体眼具有较好的临床价值.

  9. Management of Post-traumatic Aniridia with Retinal Detachment

    Institute of Scientific and Technical Information of China (English)

    Shibo Tang; Guanting Qiu; Pei Wang; Xiaoling Liang

    2001-01-01

    Purpose: To reconstruct the anatomic and functional impairment in patients with post-traumatic aniridia, aphakia, and retinal detachment. Methods: Four patients with unilateral aniridia and aphakia as well as retinal detachment as results of severe eye injuries underwent scleral buckling, vitrectomy, membrane peeling, endolaser photocoagulation, silicone oil or gas temponade, combined with iris diaphragm-IOL implantation. Results: All four patients achieved successfully anatomic and functional reconstruction after surgery. During five to 22 months postoperative follow-up, all retinas remained attached. The final visual acuity increased from finger counting to 0.1 ~ 0.3. Conclusions: The combination of vitreoretinal surgery and iris diaphrgm-IOL implantation is an effective method for post-traumatic aniridia, aphakia and traumatic retinal detachment. It could ameliorate photophobia and improve the biocular vision.Furthermore, artificial iris diaphragm implantation could prevent silicone oil-endothelia contact and salvage silicone keratopathy. Eye Science 2001; 17:35 ~ 38.

  10. 75 FR 77942 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-12-14

    ... Federal Register on January 17, 2008 (73 FR 3316), or you may visit http://edocket.access.gpo.gov/2008/pdf.... Moore, 62, has had aphakia in his left eye since childhood due to trauma. The visual acuity in his right.... Moorhead, 52, has had complete loss of vision in his right eye since childhood due to trauma. The...

  11. Anterior chamber fixation of a posterior chamber intraocular lens: A novel technique

    Directory of Open Access Journals (Sweden)

    A Sahap Kükner

    2014-01-01

    Full Text Available We aimed to evaluate the implantation of a posterior chamber intraocular lens (IOL in the anterior chamber (AC with the haptics passing through two iridectomies to the posterior chamber. A total of 33 eyes of 33 patients with inadequate posterior capsular support due to either previous aphakia or posterior capsular rupture during cataract extraction were included in the study. A double iridectomy was performed on all patients using a vitrectomy probe on the midperiphery of the iris. IOLs were implanted in the AC, and the haptics were passed through the iridectomies to the posterior chamber. The mean follow-up time was 25.3 months. AC hemorrhage occurred in five patients during the iridectomy procedure. Corneal edema was detected in eight of 14 patients with primary IOL insertions. Haptic dislocation was detected in only one patient. This technique may be a good alternative to scleral-fixated IOL implantation in eyes with aphakia.

  12. Ab interno laser sclerostomy in aphakic patients with glaucoma and chronic inflammation.

    Science.gov (United States)

    Wilson, R P; Javitt, J C

    1990-08-15

    Five patients with aphakia, glaucoma, and chronic inflammation were treated with ab interno sclerostomy by using the continuous wave Nd:YAG laser focused through a sapphire probe. After a follow-up period of 24 to 28 months, three of five patients had good intraocular pressure control. The sclerostomy failed in one patient when it was occluded by vitreous. The second failure was attributed to closure of the sclerostomy because of chronic intraocular inflammation.

  13. Cataract blindness, surgical coverage, outcome, and barriers to uptake of cataract services in Plateau State, Nigeria

    Directory of Open Access Journals (Sweden)

    Ojo P Odugbo

    2012-01-01

    Full Text Available Purpose: The purpose was to estimate the prevalence of blindness due to cataract, assess visual outcomes of cataract surgery, and determine the cataract surgical coverage rate and barriers to uptake of services among individuals aged 50 years or older in Plateau State, Nigeria. Materials and Methods: A population-based, cross-sectional survey of 4200 adults 50 years or older was performed. Multistage stratified random sampling, with probability proportional to size was used to select a representative sample. The Rapid Assessment of Cataract Surgical Services protocol was used. Statistical significance was indicated by (P 0.05. The prevalence of monocular blindness due to cataract was 5.9% (95% CI: 5.2-6.6%. The cataract surgical coverage for subjects with visual acuity (VA less 3/60 was 53.8% in the entire cohort; 60.5% for males and 48% for females (χ2 = 2.49, P > 0.05. The couching coverage for subjects who were blind was 12%. A total of 180 eyes underwent surgical intervention (surgery or couching for cataract, of which, 48 (26.7% eyes underwent couching. The prevalence of bilateral (pseudo aphakia was 1.5%, (95% CI: 1.2-1.9% and 2.7% (95% CI: 2.2-3.2% for unilateral (pseudo aphakia. Visual outcomes of the 180 eyes that underwent surgical intervention were good (VA ≥ 6/18 in 46 (25.6% eyes and poor (VA < 6/60 in 105 (58.3% eyes. Uncorrected aphakia was the most common cause of poor outcome (65.1%. Most subjects who underwent cataract surgery were not using spectacles 74 (71.2%. Cost and lack of awareness were the main barriers to uptake of cataract surgery services. Conclusion: Couching remains a significant challenge in Nigeria. The outcomes of cataract surgery are poor with the lack of aphakic correction being the main cause of the poor outcomes.

  14. [Results of intraocular lens implantation in cataract complicated by medium and high myopia].

    Science.gov (United States)

    Plotnikova, Iu A; Chuprov, A D; Volkov, D V

    2001-01-01

    Results of surgical treatment of cataract complicated by medium and high myopia are analyzed. The main group consisted of 90 patients (96 eyes) subjected to extracapsular cataract extraction with implantation of posterior-chamber intraocular lenses and the reference group of 128 patients in whom cataract was extracted without implantation of artificial lens. The study included creation of a mathematical model of myopic eye with estimation of pressure fluctuations in various zones of the eye, developing during transposition of the vitreous during patient's movements (head movements, jumps, falling) and the damping effect of the lens in the ocular system. It was proven by mathematical calculations that transpositions of jelly fractions of the vitreous decreased by 70% in an eye with the lens in comparison with their transposition in aphakia. Clinical studies demonstrated the efficiency of intraocular correction of aphakia in high myopia: implantation of an intraocular lens decreases the risk of detachment of the retina during the postoperative period and helps attain the desired refraction. PMID:11765458

  15. Fifty-year follow-up and Strampelli anterior chamber intraocular lens.

    Science.gov (United States)

    Oakley, Carmen L; Nigro, Matthew A; Vote, Brendan J

    2015-01-01

    The Strampelli anterior chamber intraocular lens was created in 1953, and was primarily used to treat myopia and aphakia. Due to the positioning of the lens, it was associated with a number of complications, and was later modified to decrease the rate of significant complications, including endothelial cell loss. This paper describes a 62-year-old man, who has had a Strampelli intraocular lens (IOL) in situ for 52 years, with relatively few complications. The case provides a framework for reflection on the significant advances in the development of IOLs since the Strampelli era. The Strampelli anterior chamber intraocular lens was created in 1953, and was primarily used to treat myopia and aphakia. Due to the positioning of the lens, it was associated with a number of complications, and was later modified to decrease the rate of significant complications, including endothelial cell loss. This paper describes a 62-year-old man, who has had a Strampelli intraocular lens (IOL) in situ for 52 years, with relatively few complications. The case provides a framework for reflection on the significant advances in the development of IOLs since the Strampelli era.

  16. Optimizing distance image quality of an aspheric multifocal intraocular lens using a comprehensive statistical design approach.

    Science.gov (United States)

    Hong, Xin; Zhang, Xiaoxiao

    2008-12-01

    The AcrySof ReSTOR intraocular lens (IOL) is a multifocal lens with state-of-the-art apodized diffractive technology, and is indicated for visual correction of aphakia secondary to removal of cataractous lenses in adult patients with/without presbyopia, who desire near, intermediate, and distance vision with increased spectacle independence. The multifocal design results in some optical contrast reduction, which may be improved by reducing spherical aberration. A novel patent-pending approach was undertaken to investigate the optical performance of aspheric lens designs. Simulated eyes using human normal distributions were corrected with different lens designs in a Monte Carlo simulation that allowed for variability in multiple surgical parameters (e.g. positioning error, biometric variation). Monte Carlo optimized results indicated that a lens spherical aberration of -0.10 microm provided optimal distance image quality.

  17. A truly knotless technique for scleral fixation of intraocular lenses: Two-year results

    Directory of Open Access Journals (Sweden)

    Naresh K Yadav

    2012-01-01

    Full Text Available Scleral fixated intraocular lens (SFIOL is a safe and effective option for managing optical aphakia. Suture related complications like suture erosion, suture breakage, endophthalmitis, etc. are unique to SFIOL. The knots can be covered by partial thickness flaps or they can be rotated into scleral tissues without flaps to reduce the complications. We performed a recently described novel technique which obviates the need for knot and scleral flaps in securing the SFIOL. This novel 2-point Ab externo knotless technique may reduce the knot related problems. Twenty-three eyes undergoing this knotless SFIOL procedure were analyzed for intraoperative and postoperative complications. Twenty-two eyes either maintained or improved on their preoperative vision. All patients had a minimum follow-up of 24 months.

  18. Diffuse epithelial ingrowth after perforating keratoplasty.

    Science.gov (United States)

    Severin, M; Kirchhof, B; Hartmann, C

    1987-01-01

    Diffuse epithelial ingrowth was observed in 2 patients after perforating keratoplasty. Both cases involved a corneal graft after perforating injury with aphakia. In the first patient, the epithelial invasion was probably stimulated by a spatula synecholysis. In this case, the diagnosis was only made by histological investigation after enucleation. In the second patient the epithelial ingrowth was observed 8 months after keratoplasty. The clinical diagnosis was made on the basis of the typical slitlamp findings. In this case, the epithelial invasion led to hypotension with high resistance of outflow measured by electrotonography. In a very close chronological relation to the probable fall of chamber fluid secretion, development of a band-shaped keratopathy was observed.

  19. Need for optical and low vision services for children in schools for the blind in North India

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    Pal Nikhil

    2006-01-01

    Full Text Available Context: Children admitted in blind schools need low vision assessment for improving functional vision (useful residual vision. Aim: To ascertain the need for spectacles and magnifiers as low vision devices (LVD in children with useful residual vision, attending blind schools. Setting and Design: Cross-sectional study conducted in 13 blind schools in Delhi, North India. Materials and Methods: Of a total of 703 children (less than 16 years of age examined, 133 (18.91% with useful residual vision were refracted and analyzed. High addition plus lenses (range 5-30 diopters were used as spectacle magnifiers for near LVD assessment. "World health organization (WHO/ prevention of blindness (PBL eye examination record for children with blindness and low vision", was used to collect data. SPSS (statistical package for the social science, version 10.0 was used for analysis. Results: Based on the vision of 133 children at initial examination, 70.7% children were blind and 12.0% were severely visually impaired (SVI. 20.3% children improved by at least one WHO category of blindness after refraction. With best correction, 50.4% children were still blind and 13.5% were SVI. Visual acuity in the better eye after refraction in 47 children (35.3%, improved with spectacles. Children with aphakia (17, coloboma (5, refractive error (5 and microphthalmos (4 benefited from spectacles. Of 124 children with low vision but having useful residual vision, 51 (41.1% were able to read N-10 unaided or with distance spectacles and 30 children (22.6% improved to N-10 with spectacle magnifiers and were prescribed the same. Conclusion: Visually impaired children with aphakia and congenital anomalies of the eye benefit from refraction and low vision services.

  20. Iris Claw versus Scleral Fixation Intraocular Lens Implantation during Pars Plana Vitrectomy

    Directory of Open Access Journals (Sweden)

    Fereydoun Farrahi

    2012-01-01

    Full Text Available Purpose: To compare the outcomes of iris claw anterior chamber intraocular lens (ICACIOL with that of scleral fixation posterior chamber intraocular lens (SF-PCIOL implantation during pars plana vitrectomy (PPV as initial surgery to correct aphakia. Methods: Twelve patients with complicated cataract surgery or trauma who had suffered nucleus, whole crystalline lens or intraocular lens (IOL drop into the vitreous cavity, and undergone PPV with IC-ACIOL implantation over a period of one year were evaluated for the purpose of this study. Uncorrected visual acuity (UCVA, best corrected visual acuity (BCVA, central corneal thickness (CCT, spherical equivalent (SE refractive error, astigmatism and complications were recorded. The results were compared to outcomes of another group of 13 patients who had previously undergone PPV with SF-PCIOL implantation. Results: Mean improvement of UCVA was greater in IC-ACIOL eyes as compared to the SF-PCIOL group (-1.17±0.28 versus -0.89±0.21 logMAR, P=0.01, corresponding values for postoperative BCVA were 0.24±0.17 and 0.44±0.22 logMAR (P=0.041, respectively. Average postoperative SE was comparable in the IC-ACIOL and SFPCIOL groups at 0.6±1.03 and 0.56±1.23 diopters, respectively (P=0.290. However, 10 (83.3% IC-ACIOL eyes versus 6 (46.1% SF-PCIOL eyes had SE within 1 diopter of emmetropia (P=0.048. Mean postoperative increase in CCT was comaparble between the study groups (P=0.126. Conclusion: In the absence of sufficient capsular support, the use of an IC-ACIOL for correction of aphakia during PPV can be a good alternative and seems to entail better visual outcomes as compared to SF-PCIOL.

  1. Novel mutations in PAX6, OTX2 and NDP in anophthalmia, microphthalmia and coloboma.

    Science.gov (United States)

    Deml, Brett; Reis, Linda M; Lemyre, Emmanuelle; Clark, Robin D; Kariminejad, Ariana; Semina, Elena V

    2016-04-01

    Anophthalmia and microphthalmia (A/M) are developmental ocular malformations defined as the complete absence or reduction in size of the eye. A/M is a highly heterogeneous disorder with SOX2 and FOXE3 playing major roles in dominant and recessive pedigrees, respectively; however, the majority of cases lack a genetic etiology. We analyzed 28 probands affected with A/M spectrum (without mutations in SOX2/FOXE3) by whole-exome sequencing. Analysis of 83 known A/M factors identified pathogenic/likely pathogenic variants in PAX6, OTX2 and NDP in three patients. A novel heterozygous likely pathogenic variant in PAX6, c.767T>C, p.(Val256Ala), was identified in two brothers with bilateral microphthalmia, coloboma, primary aphakia, iris hypoplasia, sclerocornea and congenital glaucoma; the unaffected mother appears to be a mosaic carrier. While A/M has been reported as a rare feature, this is the first report of congenital primary aphakia in association with PAX6 and the identified allele represents the first variant in the PAX6 homeodomain to be associated with A/M. A novel pathogenic variant in OTX2, c.651delC, p.(Thr218Hisfs*76), in a patient with syndromic bilateral anophthalmia and a hemizygous pathogenic variant in NDP, c.293 C>T, p.(Pro98Leu), in two brothers with isolated bilateral microphthalmia and sclerocornea were also identified. Pathogenic/likely pathogenic variants were not discovered in the 25 remaining A/M cases. This study underscores the utility of whole-exome sequencing for identification of causative mutations in highly variable ocular phenotypes as well as the extreme genetic heterogeneity of A/M conditions. PMID:26130484

  2. Cross-sectional investigation of visual impairing diseases in Shanghai blind children school

    Institute of Scientific and Technical Information of China (English)

    ZHU Jian-feng; ZOU Hai-dong; HE Xian-gui; LU Li-na; ZHAO Rong; XU Hong-mei; LIANG Qing-feng

    2012-01-01

    Background The control of blindness in children is a high priority within the VISION 2020 initiative.To determine the causes of severe visual impairment and blindness in children from Shanghai Blind Children School (SBCS) can provide useful information on childhood blindness in Shanghai.Methods A cross-sectional investigation of students in SBCS was conducted in May 2010.The World Health Organization/Prevention of Blindness (WHO/PBL) eye examination record system for children with low vision and blindness was used.The results were further compared with the findings of two previous investigation studies conducted in 1986 and 2004,respectively in SBCS.Results Of the 146 children observed,80 children (54.8%) were blind (best corrected best visual acuity less than 0.05),27 children (18.5%) had severe visual impairment (best corrected visual acuity less than 0.1 but better than or equal to 0.05),and 34 children (23.3%) had moderate visual impairment (best corrected visual acuity less than 0.3 but better than or equal to 0.1).The major affected anatomic sites in the 107 children with severe visual impairment and blindness (SVI/BL) were retina (47.7%),whole globe (16.8%),optic nerve (13.1%) and lens (9.3%).The leading causes of SVI/BL were retinopathy of prematurity (ROP,25.2%),followed by retinal dystrophy (15.9%),optic nerve atrophy (9.3%) and microphthalmos (9.3%).The two leading etiologic categories of SVI/BL were perinatal/neonatal (36.4%) and congenital/hereditary groups (29.0%).The leading cause of moderate visual impairment was aphakia after cataract surgery (congenital cataract,44.1%).Compared with the findings in two previous investigations in SBCS,the proportion of ROP in visual impairing diseases increased,while the proportion of disorders of the lens (cataract and aphakia)significantly decreased.Conclusions The leading cause of childhood blindness in SBCS nowadays is ROP.It is projected that without improvement in perinatal medical

  3. Evaluation of pars plana sclera fixation of posterior chamber intraocular lens

    Directory of Open Access Journals (Sweden)

    Fangju Han

    2014-01-01

    Full Text Available Purpose: The purpose of this study was to evaluate the clinical efficacy and safety of modified posterior chamber intraocular lens (PCIOL implantation with transscleral fixation. Design and Setting: This is a study, which is conducted at Department of Ophthalmology, Jinan Eye Hospital, Jinan Second People′s Hospital. Materials and Methods: A total of 82 patients who were scheduled for sutured PCIOL were divided randomly into modified and conventional groups. The former underwent PCIOL through pars plana fixation with knot buried and without scleral flap and the latter underwent transscleral fixation of PCIOL in the ciliary sulcus. The main outcome measures included operative time, postoperative visual acuity, and postoperative complications. Results: The mean operative time of the modified group was 39.95 ± 5.87 min, which was significantly less than that of the conventional group (45.77 ± 5.21 min; P < 0.05. No difference was found in postoperative visual acuity between the two groups. There were no significant postoperative complications, including knot exposure, endophthalmitis, and retinal detachment in either group. The optical clamping of PCIOL was prone to occur in the conventional group. Conclusion: Modified sutured PCIOL implantation is a safe, effective, and feasible technique for the correction of aphakia in eyes without adequate posterior capsular support.

  4. Single-plate Molteno implants in complicated glaucomas : Results, survival rates, and complications

    Directory of Open Access Journals (Sweden)

    Neelakantan Arvind

    1994-01-01

    Full Text Available Sixty-two single-plate single-stage Molteno implantations for complicated glaucomas were performed between March 1991 and November 1992. The charts of all these patients were reviewed to determine the intraocular pressure (IOP control success rate (< 21 mm Hg with or without medications, visual success rate (retention or improvement of visual acuity from preoperative level and the rate of complications encountered. A Kaplan-Meier life-table (survival analysis was also performed. IOP control was obtained in 74.2% of cases. Mean postoperative IOP was 16.97 +/- 8.07 mm Hg (Mean +/- SD. Visual success was obtained in 51.6% of the eyes. Eyes with aphakia/pseudophakic glaucomas showed the best response with 80% of them achieving IOP control and 60% achieving visual success. The survival plot for IOP control revealed 75.81% and 74.19% success rates at 48 and 72 weeks, respectively. Complications encountered were either due to the early postoperative hypotony or were tube-related. These results were gratifying considering the severity of the glaucoma in these cases and they reaffirm the usefulness of the Molteno implant in the management of difficult glaucomas.

  5. Pitfalls in aphakic contact lens fitting

    Directory of Open Access Journals (Sweden)

    Dada Vijay

    1990-01-01

    Full Text Available We examined 23 consecutive cases of unilateral aphakia reporting to the contact lens office for endothelial count and morphology, corneal thickness and toricity. The fellow eye served as a control in all the cases. It was found that there is a significant drop in the central endothelial cell density, and change in the size and shape of the cells. These observations indicate a thermodynamically unstable state. The aphakic corneas were thicker than the controls but not to a significant extent. The cell count and pachymetry had no statistical correlation. Toricity of the aphakic corneas make successful fitting of a lens difficult. Since prolonged use of extended wear gas permeable as well as hydrogel lenses have a deleterious effect on the endothelium it is suggested that a careful case selection be made and strict monitoting carried out at follow up. These corneas are liable for decompensation with only mild noxious stimuli. This article is intended to acquaint the ophthalmologist with the pitfalls in aphakic contact lens fitting so that a cautious follow up may be planned.

  6. Intraocular lenses and clinical treatment in paediatric cataract

    Directory of Open Access Journals (Sweden)

    Camila Ribeiro Koch Pena

    2015-06-01

    Full Text Available Pediatric cataract is the most common treatable cause of blindness in children. Prevalence, etiology and morphology vary with the socioeconomic development. The treatment goal is to reduce amblyopia, being difficult management especially in unilateral cases. The decision on aphakia or primary intraocular lens should be individualized as well as correction with contact lens or spectacles. The intraocular lens single-piece hydrophobic acrylic are the most implanted in children and the preferably is in the capsular bag. The Sanders-Retzlaff-Kraff theoretic (SRK/T stressing that is described as more predictable, following Holladay I and SRK II and the recommendation is to under correction +6.0 or +8.0 dioptrias expecting the growth of the eye. The posterior capsule opacity is the most frequent complication and varies with the material choice of the lens. Glaucoma is the most serious postoperative complication and depends on the timing of the surgery, primary lens implantation and time of post surgical follow-up. The adherence to occlusion therapy with patching is critical to the visual prognosis and is determined by the child’s age and laterality of the cataract. There was significant improvement in the surgery and in IOLs, however the final visual prognosis is still not desirable.

  7. Mouse models of congenital cataract.

    Science.gov (United States)

    Graw, J

    1999-06-01

    Mouse mutants affecting lens development are excellent models for corresponding human disorders. The mutant aphakia has been characterised by bilaterally aphakic eyes (Varnum and Stevens, J Hered 1968;59:147-50); the corresponding gene was mapped to chromosome 19 (Varnum and Stevens, Mouse News Lett 1975;53:35). Recent investigations in our laboratory refined the linkage of 0.6 cM proximal to the marker D19Mit10. Several candidate genes have been excluded (Chuk1, Fgf8, Lbp1, Npm3, Pax2, Pitx3). The Cat3 mutations are characterised by vacuolated lenses caused by alterations in the initial secondary lens fibre cell differentiation. Secondary malformations develop at the cornea and iris, but the retina remains unaffected. The mutation has been mapped to chromosome 10 close to the markers D10Mit41 and D10Mit95. Several candidate genes have been excluded (Dcn, Elk3, Ldc, Mell8, Tr2-11). The series of Cat2 mutations have been mapped close to the gamma-crystallin genes (Cryg; Löster et al., Genomics 1994;23:240-2). The Cat2nop mutation is characterised by a mutation in the third exon of Crygb leading to a truncated gamma B-crystallin and the termination of lens fibre cell differentiation. The Cat2 mutants are interesting models for human cataracts caused by mutations in the human CRYG genes at chromosome 2q32-35. PMID:10627821

  8. 儿童白内障手术的研究进展%Progress on pediatric cataract surgery

    Institute of Scientific and Technical Information of China (English)

    田芳; 张红

    2013-01-01

    Cataract surgery is the most commonly performed intraocular surgery in the pediatric population.Although the basic surgical techniques have not significantly changed over the last several years,there are many related issues under continual debate and research.These include use of local perioperative anesthesia,capsular management,type and power of intraocular lenses (IOLs),sutured IOLs,and risk of subsequent glaucoma.Besides,the Infant Aphakia Treatment Study has published the early report.%白内障手术是儿童内眼手术中最常见的手术,虽然近年来基本手术技术未见更多进展,但仍有许多研究着眼于争论性问题,如围手术期的局部麻醉、囊膜的处理、人工晶状体的类型和度数选择、人工晶状体缝合术、继发性青光眼的风险等.另外,多中心“婴儿无晶状体眼治疗研究”也有了早期的研究结果.

  9. Congenital Cataract:Progress in Surgical Treatment and Postoperative Recovery of Visual Function

    Institute of Scientific and Technical Information of China (English)

    Mingyue Wang; Wei Xiao

    2015-01-01

    Congenital cataract is a common cause of childhood low vi-sion or blindness worldwide..Early surgery should be per-formed in sensitive vision development period to avoid vision deprivation in cases of strabismus and nystagmus develop-ment. Postoperative recovery of visual function is of great sig-nificance for these patients and should include proper postop-erative aphakia correction by the application of a contact lens and secondary implantation of an intraocular lens (IOL). Pa-tients should receive amblyopic training after surgery to im-prove their postoperative visual acuity..Although recent ad-vances in surgery techniques and materials have brought better postoperative visual acuity and less complications , a few post-operative complications can still hamper vision condition and vision development,.including posterior capsule opacification and secondary glaucoma. Surgery in early infancy are risk fac-tors for these two complications..Life-long follow-up is essen-tial for these patients..Further study will continue to address the surgery timing issue and methods that prevent postopera-tive complications.

  10. Role of 5 fluorouracil in the management of failed glaucoma surgery

    Directory of Open Access Journals (Sweden)

    Sood N

    1990-01-01

    Full Text Available Filtering surgery for glaucoma usually controls the intraocular pressure adequately. However, in glaucoma patients with aphakia, neovascularisation of iris, previous failed filtering surgeries and relatively young patients, results of surgery leave much scope for improvement. Most failures of filtering surgery are related to extra-ocular factors. Histopathological studies of eyes after failed filtering operations have suggested that proliferation of fibroblasts and deposition of collagen constitute a barrier to filteration. There is also a positive correlation between success of filtering surgery and inhibition of fibroblast growth by the patients aqueous humour. Thus agents inhibiting fibroblast proliferation should play an important role in increasing the success rate of filtering surgery. 5 Fluorouracil is a pyrimidine analogue which has been utilised for over 15 years as an antimetabolite in cancer therapy. Its efficiency in inhibiting fibroblast proliferation in vitro and in rabbit eyes has been proved beyond doubt. We undertook a pilot project to estimate the efficiency of the subconjunctival 5 FU to increase the changes of success in problematic cases of glaucoma in pigmented eyes.

  11. Intraocular lens iris fixation. Clinical and macular OCT outcomes

    Directory of Open Access Journals (Sweden)

    Garcia-Rojas Leonardo

    2012-10-01

    Full Text Available Abstract Background To assess the efficacy, clinical outcomes, visual acuity (VA, incidence of adverse effects, and complications of peripheral iris fixation of 3-piece acrylic IOLs in eyes lacking capsular support. Thirteen patients who underwent implantation and peripheral iris fixation of a 3-piece foldable acrylic PC IOL for aphakia in the absence of capsular support were followed after surgery. Clinical outcomes and macular SD-OCT (Cirrus OCT; Carl Zeiss Meditec, Germany were analyzed. Findings The final CDVA was 20/40 or better in 8 eyes (62%, 20/60 or better in 12 eyes (92%, and one case of 20/80 due to corneal astigmatism and mild persistent edema. No intraoperative complications were reported. There were seven cases of medically controlled ocular hypertension after surgery due to the presence of viscoelastic in the AC. There were no cases of cystoid macular edema, chronic iridocyclitis, IOL subluxation, pigment dispersion, or glaucoma. Macular edema did not develop in any case by means of SD-OCT. Conclusions We think that this technique for iris suture fixation provides safe and effective results. Patients had substantial improvements in UDVA and CDVA. This surgical strategy may be individualized however; age, cornea status, angle structures, iris anatomy, and glaucoma are important considerations in selecting candidates for an appropriate IOL fixation method.

  12. FOXE3 plays a significant role in autosomal recessive microphthalmia.

    Science.gov (United States)

    Reis, Linda M; Tyler, Rebecca C; Schneider, Adele; Bardakjian, Tanya; Stoler, Joan M; Melancon, Serge B; Semina, Elena V

    2010-03-01

    FOXE3 forkhead transcription factor is essential to lens development in vertebrates. The eyes of Foxe3/foxe3-deficient mice and zebrafish fail to develop normally. In humans, autosomal dominant and recessive mutations in FOXE3 have been associated with variable phenotypes including anterior segment anomalies, cataract, and microphthalmia. We undertook sequencing of FOXE3 in 116 probands with a spectrum of ocular defects ranging from anterior segment dysgenesis and cataract to anophthalmia/microphthalmia. Recessive mutations in FOXE3 were found in four of 26 probands affected with bilateral microphthalmia (15% of all bilateral microphthalmia and 100% of consanguineous families with this phenotype). FOXE3-positive microphthalmia was accompanied by aphakia and/or corneal defects; no other associated systemic anomalies were observed in FOXE3-positive families. The previously reported c.720C > A (p.C240X) nonsense mutation was identified in two additional families in our sample and therefore appears to be recurrent, now reported in three independent microphthalmia families of varied ethnic backgrounds. Several missense variants were identified at varying frequencies in patient and control groups with some apparently being race-specific, which underscores the importance of utilizing race/ethnicity-matched control populations in evaluating the relevance of genetic screening results. In conclusion, FOXE3 mutations represent an important cause of nonsyndromic autosomal recessive bilateral microphthalmia.

  13. c-Myc regulates cell proliferation during lens development.

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    Gabriel R Cavalheiro

    Full Text Available Myc protooncogenes play important roles in the regulation of cell proliferation, growth, differentiation and survival during development. In various developing organs, c-myc has been shown to control the expression of cell cycle regulators and its misregulated expression is detected in many human tumors. Here, we show that c-myc gene (Myc is highly expressed in developing mouse lens. Targeted deletion of c-myc gene from head surface ectoderm dramatically impaired ocular organogenesis, resulting in severe microphtalmia, defective anterior segment development, formation of a lens stalk and/or aphakia. In particular, lenses lacking c-myc presented thinner epithelial cell layer and growth impairment that was detectable soon after its inactivation. Defective development of c-myc-null lens was not caused by increased cell death of lens progenitor cells. Instead, c-myc loss reduced cell proliferation, what was associated with an ectopic expression of Prox1 and p27(Kip1 proteins within epithelial cells. Interestingly, a sharp decrease in the expression of the forkhead box transcription factor Foxe3 was also observed following c-myc inactivation. These data represent the first description of the physiological roles played by a Myc family member in mouse lens development. Our findings support the conclusion that c-myc regulates the proliferation of lens epithelial cells in vivo and may, directly or indirectly, modulate the expression of classical cell cycle regulators in developing mouse lens.

  14. Causes of childhood blindness in the northeastern states of India

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    Bhattacharjee Harsha

    2008-01-01

    Full Text Available Background: The northeastern region (NER of India is geographically isolated and ethno-culturally different from the rest of the country. There is lacuna regarding the data on causes of blindness and severe visual impairment in children from this region. Aim: To determine the causes of severe visual impairment and blindness amongst children from schools for the blind in the four states of NER of India. Design and Setting: Survey of children attending special education schools for the blind in the NER. Materials and Methods: Blind and severely visually impaired children (best corrected visual acuity < 20/200 in the better eye, aged up to 16 years underwent visual acuity estimation, external ocular examination, retinoscopy and fundoscopy. Refraction and low vision workup was done where indicated. World Health Organization′s reporting form was used to code anatomical and etiological causes of visual loss. Statistical Analysis: Microsoft Excel Windows software with SPSS. Results: A total of 376 students were examined of whom 258 fulfilled the eligibility criteria. The major anatomical causes of visual loss amongst the 258 were congenital anomalies (anophthalmos, microphthalmos 93 (36.1%; corneal conditions (scarring, vitamin A deficiency 94 (36.7%; cataract or aphakia 28 (10.9%, retinal disorders 15 (5.8% and optic atrophy 14 (5.3%. Nearly half of the children were blind from conditions which were either preventable or treatable (48.5%. Conclusion: Nearly half the childhood blindness in the NER states of India is avoidable and Vitamin A deficiency forms an important component unlike other Indian states. More research and multisectorial effort is needed to tackle congenital anomalies.

  15. Efficacy and safety of active silicone oil removal through a 23-gauge transconjunctival cannula using an external vacuum pump

    Institute of Scientific and Technical Information of China (English)

    Hyun; Ju; Oh; Woohyok; Chang; Min; Sagong

    2015-01-01

    AIM: To evaluate the efficacy and safety of active removal of silicone oil with low and high viscosity through a 23-gauge transconjunctival cannula using an external vacuum pump.METHODS: This study was conducted as a prospective, interventional case series. A total of 22 eyes of 21 patients [1000 centistokes(c St): 17 eyes, 5700 c St:5 eyes] were included in this study. All patients underwent active silicone oil removal via the entire lumen of a 23-gauge microcannula with suction pressure of a650-700 mm Hg vacuum using an external vacuum pump. A tubing adaptor from the Total Plus Pak誖(Alcon,Fort Worth, USA) was used to join the microcannula and silicone vacuum tube connected to an external vacuum pump. Main outcome measures were mean removal time,changes of intraocular pressure(IOP) and visual acuity,and intraoperative and postoperative complications.RESULTS: Mean removal time(min) was 1.49±0.43 for1000 c St and 7. 12 ± 1. 27 for 5700 c St. The IOP was18.57±7.48 mm Hg at baseline, 11.68 ±4.55 mm Hg at day1 postoperatively(P <0.001), and 15.95±4.92, 16.82±3.81,17.41 ±3.50, and 17.09 ±3.01 mm Hg after one week, one month, three months, and six months, respectively. All patients showed improved or stabilized visual acuity.There was no occurrence of intraoperative or postoperative complications during the follow up period.CONCLUSION: This technique for active removal of silicone oil through a 23-gauge cannula using an external vacuum pump is fast, effective, and safe as well as economical for silicone oil with both low and high viscosity in all eyes with pseudophakia, aphakia, or phakia.

  16. Pediatric cataract: challenges and future directions

    Directory of Open Access Journals (Sweden)

    Medsinge A

    2015-01-01

    cataract, aphakia, pseudophakia

  17. Pars Plana Vitrectomy and Silicone Oil Injection in Phakic and Pseudophakic Eyes; Corneal Endothelial Changes

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    Fereydoun Farrahi

    2014-01-01

    Full Text Available Purpose: To evaluate the effect of silicone oil (SO on the corneal endothelium in SO filled phakic and pseudophakic vitrectomizied eyes. Methods: This prospective comparative consecutive case-control study evaluated the corneal endothelial characteristics of 64 SO filled vitrectomizied eyes (case group as compared to 46 vitrectomizied eyes without SO injection (control group. Endothelial cell densities (ECD, coefficient of variation (CV, and percentage of hexagonal cells (hexagonality at the corneal center were evaluated preoperatively, 1 month and 6 months after surgery using noncontact specular microscopy and were compared between the two groups. Exclusion criteria were previous vitreoretinal surgery, aphakia, any degree of anterior chamber inflammation, SO bubbles in the anterior chamber and increased intraocular pressure in the postoperative period. Results: Six months after SO injection, mean ECD was 2,438.2±327.6 cell/mm 2 in the case group and 2,462.6±361.7 cell/mm 2 in the control group (P = 0.714 and mean hexagonality was 49.6 ± 6.8 and 54.6 ± 8.9, in the case and control groups, respectively (P = 0.004. Six months after operation, CV in the case group was 39.3 ± 5.6 and that in the control group was 35.7 ± 6.4 (P = 0.003. Conclusion: Although the presence of SO in the vitreous cavity of phakic and pseudophakic eyes causes slight reduction in the number of endothelial cells, however it leads to significant changes in endothelial cell morphology. Thus, removal of SO after reaching the desired tamponade effect is recommended.

  18. 穿透性角膜移植患者植片衰竭和植片排斥的危险因素分析%Risk factors for corneal graft failure and rejection in penetrating keratoplasty

    Institute of Scientific and Technical Information of China (English)

    杨艳峰; 黄一飞; 王丽强; 尹东方; 张鲲

    2004-01-01

    · AIM: To evaluate risk factors of graft failure and allograft rejection after penetrating keratoplasty (PK).· METHODS: Clinical data of PKs on 224 eyes (212 patients) from 1993 to 2003 were studied retrospectively.The graft survival rate and rejection-free survival rate over 10a were estimated with Kaplan-Meir′s life table method, and differences between levels of each factor were compared with log-rank test. Cox regression was also performed to further assess the impact of related clinical factors on the prognosis of the corneal graft.· RESULTS: The overall rates of graft survival and rejection-free graft survival at 10a after PK were 81.4% and 78.2% respectively. Relatively higher risk of graft failure was associated with corneal vascularization, regraft,aphakia or pseudophakia, presence of anterior or posterior synechia, long (≥90min) operation time and older (≥60a) age of recipient. Relatively higher risk of rejection was associated with corneal vascularization and long operation time. Cox regression analysis showed corneal vascularization (RR=2.46, P=0.04), regraft (RR=5.67,P<0.01), aphakia (RR =3.64, P<0.05), or pseudophakia (RR=6.83,P<0.01), presence of anterior (RR=2.76, P=0.05) or posterior synechia (RR=3.12, P=0.05) were independent risk factors for corneal graft failure.· CONCLUSION: The risk factors for graft failure after PK were corneal vascularization, regraft, aphakia or pseudophakia, presence of anterior or posterior synechia. The risk factors after PK for allograft rejection were corneal vascularization and long operation time.%目的:评价穿透性角膜移植(PK)手术眼科患者中,影响角膜植片存活和植片发生免疫排斥反应的临床因素.方法:回顾性分析解放军总医院眼科1993/2003年间,212例患者,224眼穿透性角膜移植手术的临床资料,以Kaplan-Meir's方法计算其预期10a植片存活率及10a植片无免疫排斥存活率,对各因素水平间采用log-rank检验比较其差异,计

  19. 玻璃体切除硅油填充术后高眼压临床分析%Clinical analysis of intraocular pressure(IOP) elevation after vitrectomy and silicon oil tamponade

    Institute of Scientific and Technical Information of China (English)

    黄庆; 张军军

    2012-01-01

    Objective To investigate the causes and measurements of intraocular pressure (IOP) elevation after vitrectomy. Methods To retrospectively analyze clinical data of thirty-one eyes out of one hundred and sixty patients (one hundred and seventy-eight eyes) which had IOP elevation in early period after vitrectomy from January,2010 to December, 2010. Results The causes of postoperative IOP elevation ate uveitic inflammation (eighteen eyes, 58. 1% ), aphakia (four eyes, 12.9%), steroids ((our eyes, 12.9%), silicon oil tamponade excess (three eyes, 9.7%) and endoph-thalmitis (two eyes, 6.5%). After various treatments such as IOP-lowering medication, stop using of steroids, taken-out part of silicon oil, paracentesis of anterior chamber and change to hign-grade antibiotics, the IOP of all eyes returned to normal. Conclusion The incidence of IOP elevation after vitrectomy is 17.4% and uveitic inflammation is the common cause. Timely prevention and proper measurement can reduce visual damage.%目的 探讨玻璃体切除硅油填充术后高眼压的原因及处理.方法 回顾性分析2010年1月到2010年12月本院160例(178只眼)玻璃体切除硅油填充术后早期发生高眼压31例(31只眼)的临床资料.结果 术后高眼压发生原因如下:葡萄膜炎症反应(18只眼,58.1%)、无晶状体眼(4只眼,12.9%)、激素引发(4只眼,129%)、硅油填充过量(3只眼,9.7%)、眼内炎(2只眼,6.5%).给予降眼压药物、停用激素类药物、硅油部分取出、前房穿刺或换用敏感抗生素等治疗后,眼压均降至正常.结论 玻璃体切除硅油填充术后高眼压在本研究的发生率为17.4%,术后葡萄膜炎症反应为常见原因,及时的预防和处理能减少视功能的损害.

  20. EPHA2 polymorphisms and age-related cataract in India.

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    Periasamy Sundaresan

    Full Text Available OBJECTIVE: We investigated whether previously reported single nucleotide polymorphisms (SNPs of EPHA2 in European studies are associated with cataract in India. METHODS: We carried out a population-based genetic association study. We enumerated randomly sampled villages in two areas of north and south India to identify people aged 40 and over. Participants attended a clinical examination including lens photography and provided a blood sample for genotyping. Lens images were graded by the Lens Opacification Classification System (LOCS III. Cataract was defined as a LOCS III grade of nuclear ≥4, cortical ≥3, posterior sub-capsular (PSC ≥2, or dense opacities or aphakia/pseudophakia in either eye. We genotyped SNPs rs3754334, rs7543472 and rs11260867 on genomic DNA extracted from peripheral blood leukocytes using TaqMan assays in an ABI 7900 real-time PCR. We used logistic regression with robust standard errors to examine the association between cataract and the EPHA2 SNPs, adjusting for age, sex and location. RESULTS: 7418 participants had data on at least one of the SNPs investigated. Genotype frequencies of controls were in Hardy-Weinberg Equilibrium (p>0.05. There was no association of rs3754334 with cataract or type of cataract. Minor allele homozygous genotypes of rs7543472 and rs11260867 compared to the major homozygote genotype were associated with cortical cataract, Odds ratio (OR = 1.8, 95% Confidence Interval (CI (1.1, 3.1 p = 0.03 and 2.9 (1.2, 7.1 p = 0.01 respectively, and with PSC cataract, OR = 1.5 (1.1, 2.2 p = 0.02 and 1.8 (0.9, 3.6 p = 0.07 respectively. There was no consistent association of SNPs with nuclear cataract or a combined variable of any type of cataract including operated cataract. CONCLUSIONS: Our results in the Indian population agree with previous studies of the association of EPHA2 variants with cortical cataracts. We report new findings for the association with PSC which is

  1. Safety and effectiveness of a glistening-free single-piece hydrophobic acrylic intraocular lens (enVista

    Directory of Open Access Journals (Sweden)

    Packer M

    2013-09-01

    Full Text Available Mark Packer,1 Luther Fry,2 Kevin T Lavery,3 Robert Lehmann,4 James McDonald,5 Louis Nichamin,6 Brian Bearie,7,† Jon Hayashida,8 Griffith E Altmann,8 Omid Khodai8 1Department of Ophthalmology, Oregon Health and Science University, Eugene, OR, USA; 2University of Kansas Medical Center, Kansas City, KS, USA; 3Wayne State University, Detroit, MI, USA; 4Baylor College of Medicine, Houston, TX, USA; 5University of Arkansas for Medical Sciences, Little Rock, AR, USA; 6Laurel Eye Clinic, Brookville, PA, USA; 7Grand Rapids Eye Institute, Grand Rapids, MI, USA; 8Bausch & Lomb, Aliso Viejo, CA, USA †Brian Bearie passed away on March 9, 2011 Purpose: To evaluate the safety and effectiveness of a single-piece hydrophobic acrylic intraocular lens (IOL; enVista model MX60; Bausch & Lomb, Rochester, NY, USA when used to correct aphakia following cataract extraction in adults. Methods: This was a prospective case series (NCT01230060 conducted in private practices in the US. Eligible subjects were adult patients with age-related cataract amenable to treatment with standard phacoemulsification/extracapsular cataract extraction. With follow-up of 6 months, primary safety and effectiveness end points included the rates of US Food and Drug Administration (FDA-defined cumulative and persistent adverse events and the percentage of subjects who achieved best-corrected visual acuity (BCVA of 20/40 or better at final visit. To evaluate rotational stability, subjects were randomized (1:1:1:1 to have the lens implanted in one of four axis positions in 45° increments. Results: A total of 122 subjects were enrolled. The rate of cumulative and persistent adverse events did not significantly exceed historical controls, as per FDA draft guidance. At the final postoperative visit, all subjects (100% achieved a BCVA of 20/40 compared with the FDA historical control of 96.7%. Rotation of the IOL between the two final follow-up visits was ≤5° for 100% of eyes, and refractive

  2. Amblyopia after unilateral infantile cataract extraction after six weeks of age Ambliopia no pós-operatório de catarata congênita unilateral operada após seis semanas de vida

    Directory of Open Access Journals (Sweden)

    Fábio Ejzenbaum

    2009-10-01

    Full Text Available PURPOSE: To determine interocular grating acuity difference in children treated for unilateral infantile cataract. METHODS: A group of 27 children previously treated for unilateral infantile cataract, had their monocular visual acuity measured by sweep visual evoked potentials. Interocular grating acuity difference was calculated as the absolute subtraction of monocular acuity scores. Lens status, opacity severity and eye alignment were considered for analysis. RESULTS: Mean interocular grating acuity difference obtained from unilateral cataract patients was 0.58 ± 0.20 logMAR. This result was significantly larger than 0.10 logMAR used as normative data. Children with severe opacities had a more pronounced amblyopia than the moderate ones. No significant correlation between amblyopia and strabismus or aphakia was found. CONCLUSIONS: Interocular acuity difference in this group of unilateral congenital cataract was more pronounced than previous reports, mainly because of delay in diagnosis, surgery and optical correction.OBJETIVOS: Determinar a diferença interocular da acuidade visual de resolução de grades em crianças operadas de catarata congênita unilateral. MÉTODOS: Um grupo de 27 pacientes operados de catarata congênita unilateral tiveram mensurada sua acuidade visual monocular pelo potencial visual evocado de varredura. A diferença interocular foi calculada pela subtração absoluta das acuidades monoculares. A intensidade da opacificação, implante ou não de lente intraocular e presença de estrabismo foram consideradas para análise. RESULTADOS: A média da diferença interocular foi de 0,58 ± 0,20 logMAR. Esse resultado foi significantemente maior que 0,10 logMAR, valor considerado como média normal nos estudos normativos. Crianças com opacidades intensas tiveram ambliopia mais pronunciada que os casos moderados. Não houve correlação significante entre a intensidade da ambliopia com estrabismo e afacia. CONCLUSÕES: A

  3. Clinical analysis of 46 cases of ocular trauma underwent secondary suspended intraocular lens implantation%眼外伤后行二期悬吊人工晶状体植入46例临床分析

    Institute of Scientific and Technical Information of China (English)

    蔡莉莉

    2015-01-01

    Objective To investigate the methods and results of ocular trauma underwent seeondary suspended intraocular lens implantation.Methods Forty-six cases of ocular trauma after surgical treatment showed aphakia.After they were implemented the secondary suspended intraocular lens implantation,their visual acuity before and after surgery,intraocular pressure changes and the incidence of complications were recorded and statistically analyzed after conclusion.Results After 46 cases of ocular trauma patients was conducted the secondary suspended intraocular lens implantation surgery,their visual acuity all significantly improved than before the treatment (P < 0.05),whereas no significant change in terms of intraocular pressure(P > 0.05).The complication incidence was 21.74% (10/46),of which the highest was ocular hypertension (8.70%).Conclusions Secondary suspended intraocular lens implantation after ocular trauma can significantly improve visual acuity,improve patient outcomes and prognosis,protect their quality of life.%目的 探讨眼外伤后行二期悬吊人工晶状体植入的方法及效果.方法 46例眼外伤患者经一期手术治疗后均呈现无晶状体眼,实施二期悬吊人工晶状体植入手术治疗,记录其手术前后视力、眼压变化情况及并发症发生率,进行统计学分析.结果 46例眼外伤患者经二期悬吊人工晶状体植入手术治疗后,其视力均较治疗前显著改善(P<0.05),而眼压则较治疗前无明显变化(P>0.05),相关并发症发生率为21.74%(10/46),其中高眼压发生率最高(8.70%).结论 眼外伤后给予二期悬吊人工晶状体植入手术治疗可显著改善患者视力,提高患者疗效及预后,保障其生活质量.

  4. Clinical application of the three-piece intraocular lens with optical surfaces entrapment by the posterior capsule in secondary intraocular lens implantation of the pediatric cataract for preventing lens dislocation%三片式人工晶状体光学面后囊孔嵌压术在预防儿童白内障二期人工晶状体脱位应用

    Institute of Scientific and Technical Information of China (English)

    王志亮

    2014-01-01

    目的 评价三片式人工晶状体光学面后囊孔嵌压术在预防儿童白内障二期人工晶状体脱位的临床疗效.方法 选择2009年10月至2010年11月期间在邢台市眼科医院就诊的5岁以内儿童无晶状体眼患儿76例152只眼.手术分为两组,A组(单纯人工晶状体睫状沟植入组)80只眼;B组(人工晶状体光学面后囊孔嵌压组)72只眼,随访3~19个月,平均11个月.结果 A组80只眼中有13只眼出现人工晶状体脱位,B组72只眼中只有1只眼出现人工晶状体瞳孔夹持,两组对比有统计学意义(x2=10.01,P<0.05).结论 使用光学部直径大的三片式人工晶状体,将其光学部确实地嵌压在后囊孔后,可以有效地预防儿童白内障二期人工晶状体植入术后人工晶状体脱位.%Objective To assess the clinical effects of the three-piece intraocular lens which optical surfaces were captured by the posterior capsule in secondary intraocular lens implantation of the pediatric cataract.Methods The 152 eyes of children less than 5 years old with aphakia were selected between October 2009 and November 2010.Operation was divided into two groups,Group A (the intraocular lens which were implanted at ciliary sulcus) 80 eyes,Group B (the intraocular lens which optical surfaces were captured by the posterior capsule) 72 eyes,follow-up duration was from 3 to 19 months,an average of 11 months.Results In group A,there were 13 eyes of intraocular lens dislocation.In group B,there was only 1 eye of intraocular lens captured by the pupil.There was significant difference between two groups (P <0.05).Conclusions The three-piece intraocular lens which big optical surfaces are captured by the posterior capsule can prevent the dislocation in secondary intraocular lens implantation of the pediatric cataract.

  5. Rapid Assessment of Avoidable Blindness in India.

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    John Neena

    Full Text Available BACKGROUND: Rapid assessment of avoidable blindness provides valid estimates in a short period of time to assess the magnitude and causes of avoidable blindness. The study determined magnitude and causes of avoidable blindness in India in 2007 among the 50+ population. METHODS AND FINDINGS: Sixteen randomly selected districts where blindness surveys were undertaken 7 to 10 years earlier were identified for a follow up survey. Stratified cluster sampling was used and 25 clusters (20 rural and 5 urban were randomly picked in each district.. After a random start, 100 individuals aged 50+ were enumerated and examined sequentially in each cluster. All those with presenting vision = 50 years were enumerated, and 94.7% examined. Based on presenting vision,, 4.4% (95% Confidence Interval[CI]: 4.1,4.8 were severely visually impaired (vision<6/60 to 3/60 in the better eye and 3.6% (95% CI: 3.3,3.9 were blind (vision<3/60 in the better eye. Prevalence of low vision (<6/18 to 6/60 in the better eye was 16.8% (95% CI: 16.0,17.5. Prevalence of blindness and severe visual impairment (<6/60 in the better eye was higher among rural residents (8.2%; 95% CI: 7.9,8.6 compared to urban (7.1%; 95% CI: 5.0, 9.2, among females (9.2%; 95% CI: 8.6,9.8 compared to males (6.5%; 95% CI: 6.0,7.1 and people above 70 years (20.6%; 95% CI: 19.1,22.0 compared to people aged 50-54 years (1.3%; 95% CI: 1.1,1.6. Of all blindness, 88.2% was avoidable. of which 81.9% was due to cataract and 7.1% to uncorrected refractive errors/uncorrected aphakia. CONCLUSIONS: Cataract and refractive errors are major causes of blindness and low vision and control strategies should prioritize them. Most blindness and low vision burden is avoidable.

  6. Retropupillary iris-claw intraocular lens in ectopia lentis in Marfan syndrome

    Science.gov (United States)

    Faria, Mun Yueh; Ferreira, Nuno; Neto, Eliana

    2016-01-01

    Objective To report visual outcomes, complication rate, and safety of retropupillary iris-claw intraocular lens (ICIOL) in ectopia lentis in Marfan syndrome (MFS). Design Retrospective study. Methods Six eyes of three MFS patients with ectopia lentis underwent surgery for subluxation lens and retropupillary ICIOL implantation from October 2014 to October 2015 at the Department of Ophthalmology, Santa Maria Hospital in Lisbon, Portugal. Demographics, preoperative and postoperative best-corrected visual acuity (BCVA), and intraocular pressure were evaluated. Endothelium cell count was assessed using specular microscopy; anterior chamber depth was measured using Pentacam postoperatively; and intraocular lens position was viewed by ultrasound biomicroscopy. All patients were female; mean age was 20±14.264 years (range: 7–38 years). Results The average follow-up period was 6.66 months (range: 4–16 months). Preoperative BCVA was 0.568±0.149 logMAR units, and postoperative BCVA was 0.066±0.121 logMAR units. The mean BCVA gain was −0.502±0.221 on the logMAR scale. Postoperative average astigmatism and intraocular pressure were 1.292±0.697 mmHg (range: 0.5–2.25 mmHg) and 16 mmHg (range: 12–18 mmHg), respectively. The average endothelial cell density decreased from 3,121±178 cells/mm2 before surgery to 2,835±533 cells/mm2 after surgery (measured at last follow-up visit) and in the last follow-up, representing an average endothelial cell loss of 9.16%. Mean anterior chamber depth was 4.01 mm (±0.77 mm), as measured by Pentacam. No complications were found intra- or postoperatively in any of the six studied eyes. Conclusion Retropupillary ICIOL implantation is a safe and effective procedure in the treatment of aphakia in MFS eyes, without capsular support after surgery for ectopia lens. The six eyes that underwent lensectomy and retropupillary ICIOL implantation have had excellent visual outcomes with no complications so far. PMID:27382335

  7. Apoptosis in the lens anlage of the heritable lens aplastic mouse (lap mouse).

    Science.gov (United States)

    Aso, S; Tashiro, M; Baba, R; Sawaki, M; Noda, S; Fujita, M

    1998-08-01

    Adult homozygous lap mice show various eye abnormalities, such as aphakia, retinal disorganization, and dysplasia of the cornea and anterior chamber. In the fetal eye of a homozygous lap mouse, the lens placode seems to develop normally. However, the lens vesicle progresses abnormally to form a mass of cells without a cavity, and the mass vanishes soon afterward. We examined cell death in the lens anlage of this mutant. The lens anlagen of homozygous lap and normal mice from days 10 to 12 of gestation were observed by light microscopy after DNA end-labeling by immunohistochemistry and by transmission electron microscopy. By light microscopy, a slight frequency of cell death was detected in the lens anlage encircling the surface ectoderm and in the anlage or in the anlage of both homozygous lap mice and normal mice at day 10 of gestation. Cell death was seen in the lens anlage encircling the surface ectoderm in the normal mouse and sporadically in the anlage of the homozygous lap mouse at day 10.5 of gestation. Cell death was visible at the area of the lens vesicle attached to the surface ectoderm and encircling the surrounding surface ectoderm in the normal mouse, and in the lens anlage encircling the surface ectoderm and the apex areas of the lens anlage in the homozygous lap mouse at day 11 of gestation. At day 12 of gestation, almost no cell death was observed in the lens anlage of the normal mouse. However, extensive areas of cell death were still seen in the lens anlage at its apex, at the inner region, and encircling the surface ectoderm in the homozygous lap mouse. Electron microscopic observation showed that the dead cells observed in the lens anlagen by light microscopy in normal and lap mice are the result of apoptosis. In lap mice, cells with cytoplasmic condensation were observed mainly at days 10 and 10.5 of gestation. Many apoptotic bodies which had been phagocytosed by adjacent cells were seen predominantly at day 11 of gestation. At day 12 of

  8. Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse).

    Science.gov (United States)

    Aso, S; Baba, R; Noda, S; Ikuno, S; Fujita, M

    2000-04-01

    Adult homozygous lap mice show various eye abnormalities such as aphakia, retinal disorganization, and dysplasia of the cornea and anterior chamber. In the fetal eye of a homozygous lap mouse, the lens placode appears to develop normally. However, the lens vesicle develops abnormally to form a mass of cells without a cavity, and the mass vanishes soon afterward. Apoptotic cell death is associated with the disappearance of the lens anlage. We examined the basement membranes of the lens anlage of this mutant by immunohistochemical methods under light microscopy using antibodies against basement membrane components of the lens anlage, type IV collagen, fibronectin, laminin, heparan sulfate proteoglycan, and entactin and by transmission electron microscopy. Immunohistochemistry showed the distribution and intensity of antibody binding to the lens anlage to be almost the same for each these antibodies regardless of the stage of gestation or whether the anlagen were from normal BALB/c or lap mice. Thus, positive continuous reactions were observed around the exterior region of the lens anlage from day 10 of gestation for type IV collagen, fibronectin, laminin, heparan sulfate proteoglycan antibodies, and at least from day 11of gestation for entactin antibody. The basement membrane lamina densa of both normal and lap mice was shown by electron microscopy to be discontinuous at days 10 and 10.5 of gestation. However, by day 11 the lamina densa was continuous in the lens anlagen of normal mice but still discontinuous in the lap mice. By day 12 of gestation, the lamina densa had thickened markedly in normal mice, whereas in lap mice it remained discontinuous and its thinness indicated hypoplasia. These results indicate that, while all basement components examined are produced and deposited in the normal region of the lens anlage in the lap mouse, the basement membrane is, for some reason, imperfectly formed. The time at which hypoplasia of the basement membrane was observed

  9. Lente de contato em crianças: aspectos epidemiológicos Contact lens in children: epidemiological aspects

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    André Luiz Alves Salame

    2008-06-01

    standard deviation of 2.42. The most common diagnosis was aphakia, in 16 (21.9% cases. Keratoconus was present in 14 (19.1%, leucoma in 11 (15%, anisometropia in 10 (13.7%, refractive errors in 9 (12.3%, irregular astigmatism in 7 (9.5%, ectopia lentis in 4 (5.4%, high myopia in one case (1.3% and one child (1.3% had no ocular pathology, just wishing to change eye color. 52 (71.2% had medical indication, 9 (12.3% had optical indication and 12 (16.4% had cosmetic indication. Contact lenses were fitted in 103 eyes, the most tested lens was rigid gas permeable in 43 (41.7%, soft lens in 41 (39.8% and cosmetic soft lens in 11 (10.6%. CONCLUSION: Aphakia was the most common diagnosis among children in use of contact lens. The incidence of medical indication was higher than the others and the most tested lens was the rigid gas permeable one.

  10. Avaliação da eficácia da facectomia com implante de lente intra-ocular na infância Efficacy of pediatric cataract extraction with intraocular lens implantation

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    Núbia Cristina de Freitas Maia

    2005-12-01

    Full Text Available OBJETIVO: Avaliar eficácia da utilização da lente intra-ocular na correção da afacia na infância, segundo a acuidade visual e alteração refracional no pós-operatório. MÉTODOS: Foram estudados trinta e três olhos de 27 crianças portadores de catarata, unilateral ou bilateral, submetidos à cirurgia de lensectomia via pars plana com implante de lente intra-ocular, associada à capsulectomia posterior primária e vitrectomia anterior. O cálculo da lente intra-ocular foi realizado com o objetivo da emetropia no pós-operatório imediato. As crianças apresentavam idades inferiores a seis anos no momento da cirurgia e foram acompanhadas em média durante 2,9 anos. Foram divididas em três grupos: crianças portadoras de catarata unilateral operadas com idade inferior a três anos (Grupo I e superior a três anos (Grupo II e grupo III formado pelas crianças portadoras de cataratas bilaterais. RESULTADOS: Acuidade visual pós-operatória obtida no último controle igual ou superior a 20/40 foi encontrada em 85% dos olhos operados. Equivalente esférico no primeiro mês pós-operatório próximo da emetropia foi obtido em 70% das crianças do grupo III e em apenas 30% do grupo I. Quanto à variação refracional pós-operatória, a miopização foi encontrada em 81,81% dos casos, sendo maior esta alteração refracional quanto menor a idade em que a criança foi submetida à cirurgia. CONCLUSÃO: Apesar da miopização pós-operatória que ocorre com o implante de lente intra-ocular na correção da afacia em crianças com menos de seis anos de idade, o resultado visual é bastante satisfatório e a correção refracional residual de fácil execução. Um seguimento pós-operatório mais prolongado há de ser necessário para o acompanhamento dos resultados a longo prazo.PURPOSE: To evaluate the efficacy of the use of intraocular lenses in the treatment of pediatric aphakia, according to postoperative visual acuity and refraction change

  11. Biometric Calculation and Refractive Results. A Study of 250 Cases of Patients Operated for Cataract Cálculo biométrico y resultados refractivos. Estudio de 250 casos operados de catarata

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    Inés Benita Zamora Galindo

    2012-02-01

    Full Text Available

    Fundamento: el implante de lentes intraoculares en la cirugía de catarata significa un avance en la corrección refractiva de la afaquia. Pero sin el estudio previo a la cirugía y el correcto cálculo de la lente intraocular, los resultados no serían satisfactorios. Objetivo: evaluar el cálculo biométrico y la refracción posquirúrgica de pacientes operados de cataratas. Metodos: estudio descriptivo realizado en el Centro de Oftalmología del Estado de Anzoátegui, Venezuela, que incluyó 250 pacientes sometidos a cirugía de catarata, a quienes previamente se les realizó refracción, queratometría, biometría y cálculo de lente intraocular. Después de la cirugía se determinó: refracción esperada por el cálculo biométrico, error refractivo posoperatorio, agudeza visual posquirúrgica sin corrección y con corrección. Resultados: predominó el sexo femenino y el grupo de edad entre 60 y 69 años. El valor más registrado de la queratometría  osciló de 43 a 44 dioptrías. El valor de la longitud axial más destacado fue de 22 a 24 mm. Las lentes intraoculares más usadas fueron de 16 a 20 dioptrías y las de 21 a 25 dioptrías. El mayor por ciento de la refracción esperada estuvo en el grupo de 0,00 a 0, 50. El error refractivo que predominó fue el de 0,50 a 1,00. En la refracción realizada al mes de la cirugía, sin cristales, más de la mitad de los pacientes obtuvo visiones entre 20/30 y 20/25. Conclusiones: se demostró la efectividad del cálculo de la lente intraocular previo a la cirugía de catarata.

    Background: the implantation of intraocular lenses in cataract surgery represents a step forward in refractive correction of aphakia. Nevertheless, without a study prior to surgery and the correct calculation of the intraocular lens, the results would not be satisfactory.

  12. Efficacy of trabeculectomy with amniotic membrane transplantation for refractory glaucoma%小梁切除术联合生物羊膜移植治疗难治性青光眼的疗效

    Institute of Scientific and Technical Information of China (English)

    侯韶宁; 付佳

    2014-01-01

    目的:评价小梁切除术联合生物羊膜治疗难治性青光眼的临床疗效。  方法:包括29例29眼具有高危因素如新生血管、葡萄膜炎、无晶状体、人工晶状体和发育性的难治性青光眼。13例行小梁切除术联合羊膜移植,16例行小梁切除术。术后观察、比较的指标包括:术后眼压、抗青光眼药物使用数量、滤过泡形态特点以及术后并发症。所有研究对象随访12 mo。  结果:术后6mo,手术完全成功:羊膜组11/13(84.6%),对照组10/16(62.5%)(P<0.05);术后12mo,手术完全成功:羊膜组10/13(76.9%),对照组10/16(62.5%)(P<0.05)。术后12mo,羊膜组和对照组眼压分别从术前50.3±11.3,49.7±10.7mmHg降至15.7±1.1,19.8±2.3mmHg (P<0.05)。由于滤过过强,对照组术后早期出现低眼压3例(18.8%),羊膜组无1例发生;对照组出现包裹性滤过泡6例(37.5%),羊膜组仅出现1例(7.7%)。  结论:小梁切除术联合羊膜移植治疗难治性青光眼与单纯小梁切除术相比,具有手术成功率高,术后眼压控制良好、平稳,术后并发症发生率低的特点。%AIM: To evaluatethe clinical efficacy of trabeculectomy combined with amniotic membrane transplantation for refractory glaucoma. METHODS:This study included 29 cases (29 eyes) with developmental refractory glaucoma at such high risks as neovascular, uveitis, aphakia, pseudophakic.Trabeculectomy with amniotic membrane transplantation was performed in 13 cases and trabeculectomy without amniotic membrane transplantation in 16 cases. The outcome measurements included postoperative intraocular pressure ( IOP ) , the used quantity of antiglaucoma medications, the morphologic characteristics of the filtering blebs and complications. All patients were followed for 12mo. RESULTS: Complete success was seen 11/13 (84.6%) in

  13. 内眼手术并发脉络膜上腔出血的处理与危险因素分析%Treatment and analysis of risk factors of suprachoroidal hemorrhage induced by intraocular surgery

    Institute of Scientific and Technical Information of China (English)

    王伟伟; 叶俊杰

    2012-01-01

    medical examination and treatment.SCH was occurred in 10 eyes during intraocular surgery,while the SCH was diagnosed in other 5 eyes 1-3 days after operation.Surgical drainage was carried out in 8 eyes,of which 3 eyes combined with vitrectomy besides surgical drainage and other 5 eyes were treated with medication alone.Results SCH was completely removed and absorbed in 12 eyes.The visual acuity was improved in 6 eyes,unchanged in 6 eyes and decreased in 3 eyes.Nine eyes complicated with retinal detachment and reattached in 6 eyes after treatment.Seven eyes combined with hypermyopia,6 eyes combined with glaucoma,and 1 eye was aphakia.Four patients combined with hypertension,and 2 patients had diabetes mellitus. Conclusions SCH induced by intraocular surgery develops rapidly and violently,and it can result in vision loss without effective treatment.Suturing surgical incision immediately,applying hypertonic agents and sclerotomy drainage are the urgent approaches to treat SCH.Medicines and/or sclerotomy could be optional according to the amount of bleeding and other ocular complication.The risk factors of SCH include myopia,glaucoma and the instantly dropping of intraocular pressure.

  14. Refractive correction for the post-penetrating keratoplasty%穿透性角膜移植术后的屈光矫正

    Institute of Scientific and Technical Information of China (English)

    谢培英; 张缨; 刘毅; 吕燕云; 唐萍

    2001-01-01

    Objective:To investigate the changes of corneal shape and how tocorrect the refractive error after penetrating keratoplasty(PKP).Methods:We reviewed retrospectively the records of 28 patients who had PKP for keratoconus and traumatic cornea leukoma with post-operative aphakia and iris damage from 1995 to 1999.We analysed the changes of refraction and corneal topography after PKP,types of correction,visual acuity and changes after contact lens(CL)fit over and in some cases,the conditions at follow-up.Results:PKP~CL fitting average 21.0±26.5 months,the time from suture removal to CL fitting average 3.1±4.5 months.Flat and steep keratometry readings are 44.43±4.91D/50.98±5.73D by auto-keratometer,and 44.73±4.93D/51.85±6.03D by corneal topographer.There is no statistical difference in both measurements.SRI value is 2.82±1.59 and SAI value 2.56±1.28.Postoperative refraction showed -4.94D±3.95D and -4.79D±2.09D astigmatism.24 eyes wear RGPCL,two eyes wear piggyback lens,one eye wear spectacle and two eyes could not be corrected.Best corrected visual acuity was 0.8~1.5,61.5% with CL and 21.4% with spectacles.Astigmatism reduced 2.50D~5.00D,myopia reduced 1.00D~3.00D after CL fitting in 9 eyes.Compared with initial CL fitting,SRI and SAI values also decreased significantly.The cell density of endothelia showed no significant changes.The use of CL was not associated with any remarkable complication and risk of rejection.Conclusions:RGPCL correction after PKP is the most effective and general safe.However,it needs for long-term careful follow-up and when necessary,replace CL on time to keep cornea in healthy condition.%目的:探讨穿透性角膜移植术(PKP)后的角膜形状改变以及如何进行屈光矫正。方法:观察最近四年施行PKP后要求进行光学矫正的圆锥角膜25例、26只眼,角膜穿通伤、外伤性白内障术后