WorldWideScience

Sample records for antiviral strategic national

  1. 2010 Strategic national plan of Science Technology and Innovation PENCTI

    International Nuclear Information System (INIS)

    The document presents the national strategic plan for Science Technology and Innovation, its history, premises, conceptual framework, the starting situation, guiding principles, strategic objectives and priority area such as new energy sources to diversify the national energy matrix, environment environment and preservation of natural resources, governance and private management with increasing levels of dependency with the development of strategic technology knowledge and innovation

  2. 78 FR 69462 - National Nanotechnology Initiative Strategic Plan; National Science and Technology Council...

    Science.gov (United States)

    2013-11-19

    ... revolution in technology and industry that benefits society. The combined, coordinated efforts of these... TECHNOLOGY POLICY OFFICE National Nanotechnology Initiative Strategic Plan; National Science and Technology... Science and Technology Policy. ] ACTION: Request for public comment. SUMMARY: The National Science...

  3. The Quest for Strategic Malaysian Quality National Primary School Leaders

    Science.gov (United States)

    Ali, Hairuddin Mohd

    2012-01-01

    Purpose: The purpose of this paper is to investigate the nine-point strategic leadership characteristics of Malaysian Quality National Primary School Leaders (QNPSL) and to indicate the implications of these findings for the current educational management and leadership practices in their quest for Malaysian quality education.…

  4. National Center for Combating Terrorism Strategic Plan, September 2003

    Energy Technology Data Exchange (ETDEWEB)

    Bechtel Nevada

    2003-09-01

    National Center for Combating Terrorism Strategic Plan is to document the mission, vision, and goals for success; define the build plan; and describe initiatives that support the U.S. Department of Homeland Security, U.S. Department of Defense, U.S. Department of Energy, U.S. Department of Justice, intelligence community, National Governors Association, and other organizations or departments with combating terrorism training, testing, and technology responsibilities.

  5. Strategic Management of Tourism in the National Parks (Case: National Park Skadar Lake)

    OpenAIRE

    Iva Bulatović; Ana Tripković Marković

    2015-01-01

    In this paper we will try to prepare strategic analysis in order to give right guidelines for national park’s management. We are going to analyze National Park Skadar Lake as a tourist destination. We will use different strategic tools for proper analysis such as Life Cycle Concept, Boston Consulting Group Matrix, Ansoff Matrix, and McKinsey matrix. A strategy that involves penetration of the market would be desirable in the case of developing excursion, cultural – religious to...

  6. 76 FR 13197 - National Institute of Environmental Health Sciences Strategic Planning

    Science.gov (United States)

    2011-03-10

    ... Strategic Planning AGENCY: National Institutes of Health (NIH), National Institute of Environmental Health... planning process is to define an overarching Vision Statement, Strategic Goals, and Implementation... background and follow the progress of this planning process, visit the NIEHS Strategic Planning Web site...

  7. Quinault Indian Nation Comprehensive Biomass Strategic Planning Project

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas, Jesus [American Community Enrichment, Elma, WA (United States)

    2015-03-31

    The overall purposes of the Quinault Indian Nation’s Comprehensive Biomass Strategic Planning Project were to: (1) Identify and confirm community and tribal energy needs; (2) Conducting an inventory of sustainable biomass feedstock availability; (3) Development of a biomass energy vision statement with goals and objectives; (4) Identification and assessment of biomass options for both demand-side and supply side that are viable to the Quinault Indian Nation (QIN); and (5) Developing a long-term biomass strategy consistent with the long-term overall energy goals of the QIN. This Comprehensive Biomass Strategic Planning Project is consistent with the QIN’s prior two-year DOE Renewable Energy Study from 2004 through 2006. That study revealed that the most viable options to the QIN’s renewable energy options were biomass and energy efficiency best practices. QIN's Biomass Strategic Planning Project is focused on using forest slash in chipped form as feedstock for fuel pellet manufacturing in support of a tribal biomass heating facility. This biomass heating facility has been engineered and designed to heat existing tribal facilities as well as tribal facilities currently being planned including a new K-12 School.

  8. 78 FR 45934 - The National Institute of Dental and Craniofacial Research (NIDCR) Strategic Plan Request for...

    Science.gov (United States)

    2013-07-30

    ... (NIDCR) Strategic Plan Request for Comments SUMMARY: NIDCR is developing a new strategic plan to guide... http://www.nidcr.nih.gov/NewsAndFeatures/Announcements/GiveUsYourIdeasforNIDCRsNextStrategicPlan or..., Acting Director, Office of Science Policy and Analysis, National Institute of Dental and...

  9. Strategic Management of Tourism in the National Parks (Case: National Park Skadar Lake

    Directory of Open Access Journals (Sweden)

    Iva Bulatović

    2015-07-01

    Full Text Available In this paper we will try to prepare strategic analysis in order to give right guidelines for national park’s management. We are going to analyze National Park Skadar Lake as a tourist destination. We will use different strategic tools for proper analysis such as Life Cycle Concept, Boston Consulting Group Matrix, Ansoff Matrix, and McKinsey matrix. A strategy that involves penetration of the market would be desirable in the case of developing excursion, cultural – religious tourism, event tourism, hunting and fishing tourism, and wine tourism. Furthermore, market diversification is essential when it comes to new tourist products such as eco-tourism, rural tourism, scientific research, MICE tourism, golf and camping tourism, while the transformation of existing and introduction of new tourist products is expected within the sport - recreational, health, culture, excursions, wine tourism, etc.The paper will provide a framework for future research in the field of strategic management of tourism development in national parks. This topic has not yet been thoroughly analyzed and it is expected to serve as the basis of a strategic plan for managing tourism in the National Park Skadar Lake and / or as an incentive for researchers to enter more deeply into the issue

  10. 75 FR 52357 - Request for Comment: National Center for Complementary and Alternative Medicine Draft Strategic Plan

    Science.gov (United States)

    2010-08-25

    ... Alternative Medicine Draft Strategic Plan ACTION: Notice. SUMMARY: The National Center for Complementary and Alternative Medicine (NCCAM) is developing its third strategic plan and invites the public to provide comments... through the NCCAM Web site. Background: The National Center for Complementary and Alternative...

  11. Strategic Plan for inventories and monitoring on National Wildlife Refuges : Adapting to environmental change

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Strategic Plan summarizes and provides a long-term perspective for how the National Wildlife Refuge System will implement a nationally coordinated effort to...

  12. Strategic planning of the National Direction of Nuclear Technology: period 2002-2005 last report

    International Nuclear Information System (INIS)

    The final report of strategic planning describes the uses and applications of the Nuclear Technology, situation, tendencies so much at international level as national, institutional organization of the Nuclear Sector in the Uruguay, assignment of the DNTN, nuclear politics of the Uruguay, development of the Net or Nuclear Sector and model proposed for Uruguay, general conclusions and Strategic Plan

  13. The strategic priorities of the national oil and gas pipeline transport system development

    Directory of Open Access Journals (Sweden)

    Ірина Миколаївна Ісаєва

    2015-01-01

    Full Text Available The retrospective analysis of legal documents governing relations between Ukraine, Russia and the European Union as part of their energy policies was performed. The strategic interests of participating countries and the strategic priorities of the governance with national oil and gas pipeline transport system development in particular were designated

  14. Do herpes zoster patients receive antivirals?: a national survey in general practice.

    NARCIS (Netherlands)

    Opstelten, W.; Essen, G.A. van; Moons, K.G.M.; Wijck, A.J.M. van; Schellevis, F.G.; Kalkman, C.J.; Verheij, T.J.M.

    2005-01-01

    BACKGROUND: The main complications of herpes zoster (HZ) are postherpetic neuralgia and, in case of HZ ophthalmicus, eye disorders. Antiviral treatment may modify the course of disease and reduce the risk of complications. OBJECTIVE: To assess which doctors' and patients' characteristics were relate

  15. National strategic challenges and the role of Lawrence Livermore National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Al-Ayat, R.A.; Chrzanowski, P.L.; Werne, R.W.

    1995-01-01

    The end of the Cold War was a water-shed event in history--an event that calls for re-evaluation of the basic assumptions and priorities of US national security that have gone essentially unchallenged for nearly 50 years. Central to this re-evaluation are the changing needs for federal Science and Technology (S and T) investment to underpin national and economic security and the role of the Department of Energy (DOE) national laboratories in fulfilling those needs. The three nuclear weapons laboratories-Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and Sandia National Laboratory (SNL)-are major constituents of DOE`s national laboratory system. They helped win the Cold War, and will undoubtedly continue to support US security S and T requirements. This paper discusses of the role these three laboratories, and LLNL in particular, can play in supporting the nation`s S and T priorities. The paper also highlights some of the changes that are necessary for the laboratories to effectively support the national S and T and economic competitiveness agenda. These issues are important to DOE and laboratory managers responsible for the development of strategic direction and implementation plans.

  16. 77 FR 76449 - Los Padres National Forest, California; Strategic Community Fuelbreak Improvement Project

    Science.gov (United States)

    2012-12-28

    ... Forest Service Los Padres National Forest, California; Strategic Community Fuelbreak Improvement Project AGENCY: Forest Service, USDA. ACTION: Notice of intent to prepare an environmental impact statement. SUMMARY: The Forest Service will prepare an environmental impact statement (EIS) to evaluate and...

  17. 76 FR 66734 - National Institute on Deafness and Other Communication Disorders Draft 2012-2016 Strategic Plan

    Science.gov (United States)

    2011-10-27

    ... HUMAN SERVICES National Institutes of Health National Institute on Deafness and Other Communication Disorders Draft 2012-2016 Strategic Plan AGENCY: National Institute on Deafness and Other Communication...). ACTION: Notice. SUMMARY: The National Institute on Deafness and Other Communication Disorders...

  18. STRATEGIC COMBINED JOINT SPECIAL OPERATIONS AND THE BALANCE BETWEEN NATIONAL AND COMMON INTEREST

    Directory of Open Access Journals (Sweden)

    Florin NEGULESCU

    2011-01-01

    Full Text Available This paper’s purpose is to explore how the relation between national interest and common interest of different countries determine them to build a transnational military alliance in order to achieve common strategic aims by launching strategic combined joint special operations. Those common strategic aims are composed, in variable percentages, of the partners’ national goals. The use of special operations for achieving national objectives is made after all political possibilities are ruled out and when using conventional forces is neither necessary nor recommended. The balance between the coalition’s common interest and member states’ national interest influences the strength of the partnership. There are three types of relations between the common interest of the coalition and the national interest of a state: direct, complementary, and opportunistic relationships

  19. Applying national survey results for strategic planning and program improvement: the National Diabetes Education Program.

    Science.gov (United States)

    Griffey, Susan; Piccinino, Linda; Gallivan, Joanne; Lotenberg, Lynne Doner; Tuncer, Diane

    2015-02-01

    Since the 1970s, the federal government has spearheaded major national education programs to reduce the burden of chronic diseases in the United States. These prevention and disease management programs communicate critical information to the public, those affected by the disease, and health care providers. The National Diabetes Education Program (NDEP), the leading federal program on diabetes sponsored by the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC), uses primary and secondary quantitative data and qualitative audience research to guide program planning and evaluation. Since 2006, the NDEP has filled the gaps in existing quantitative data sources by conducting its own population-based survey, the NDEP National Diabetes Survey (NNDS). The NNDS is conducted every 2–3 years and tracks changes in knowledge, attitudes and practice indicators in key target audiences. This article describes how the NDEP has used the NNDS as a key component of its evaluation framework and how it applies the survey results for strategic planning and program improvement. The NDEP's use of the NNDS illustrates how a program evaluation framework that includes periodic population-based surveys can serve as an evaluation model for similar national health education programs.

  20. Strategic plan for the National Mapping Divison of the U.S. Geological Survey

    Science.gov (United States)

    ,

    1997-01-01

    The National Mapping Division (NMD) has developed this comprehensive strategic plan to chart its course over the next decade. To meet the challenge of the future, the NMD is changing its program emphasis, methods of responding to customer need and business practices. The NMD Strategic Plan identifies the new direction for the Division through a series of goals and actions for managers to use in formulating plans, establishing program emphasis, and determining resource needs and allocations into the next century.

  1. The competitive advantage of nations: the importance of the national environment for strategic management in the EC

    NARCIS (Netherlands)

    F.A.J. van den Bosch (Frans); T. Elfring (Tom); P. de Wolf (Peter)

    1991-01-01

    textabstractSummary: In this paper we investigate the usefulness for strategic management of Porter's framework of analysis of the competitive advantage of nations in particular regarding the importance of the changing national environment within the EC. It appears that Porter's framework - suppleme

  2. Attitudes of Employees of Provincial Directorates of National Education and School Administrators towards Strategic Planning

    Science.gov (United States)

    Altinkurt, Yahya

    2010-01-01

    The aim of the study is to determine the attitudes of employees of Provincial Directorates of National Education and school administrators towards strategic planning. The research was designed as a survey model study. The population of the research consisted of employees of Provincial Directorate of National Education of Kutahya and school…

  3. Impact of emerging antiviral drug resistance on influenza containment and spread: influence of subclinical infection and strategic use of a stockpile containing one or two drugs.

    Directory of Open Access Journals (Sweden)

    James M McCaw

    Full Text Available BACKGROUND: Wide-scale use of antiviral agents in the event of an influenza pandemic is likely to promote the emergence of drug resistance, with potentially deleterious effects for outbreak control. We explored factors promoting resistance within a dynamic infection model, and considered ways in which one or two drugs might be distributed to delay the spread of resistant strains or mitigate their impact. METHODS AND FINDINGS: We have previously developed a novel deterministic model of influenza transmission that simulates treatment and targeted contact prophylaxis, using a limited stockpile of antiviral agents. This model was extended to incorporate subclinical infections, and the emergence of resistant virus strains under the selective pressure imposed by various uses of one or two antiviral agents. For a fixed clinical attack rate, R(0 rises with the proportion of subclinical infections thus reducing the number of infections amenable to treatment or prophylaxis. In consequence, outbreak control is more difficult, but emergence of drug resistance is relatively uncommon. Where an epidemic may be constrained by use of a single antiviral agent, strategies that combine treatment and prophylaxis are most effective at controlling transmission, at the cost of facilitating the spread of resistant viruses. If two drugs are available, using one drug for treatment and the other for prophylaxis is more effective at preventing propagation of mutant strains than either random allocation or drug cycling strategies. Our model is relatively straightforward, and of necessity makes a number of simplifying assumptions. Our results are, however, consistent with the wider body of work in this area and are able to place related research in context while extending the analysis of resistance emergence and optimal drug use within the constraints of a finite drug stockpile. CONCLUSIONS: Combined treatment and prophylaxis represents optimal use of antiviral agents to

  4. Strategic Leadership for Large-Scale Reform: The Case of England's National Literacy and Numeracy Strategy

    Science.gov (United States)

    Leithwood, Kenneth; Jantzi, Doris; Earl, Lorna; Watson, Nancy; Levin, Benjamin; Fullan, Michael

    2004-01-01

    Both 'strategic' and 'distributed' forms of leadership are considered promising responses to the demands placed on school systems by large-scale reform initiatives. Using observation, interview and survey data collected as part of a larger evaluation of England's National Literacy and Numeracy Strategies, this study inquired about sources of…

  5. 78 FR 47003 - Draft National Spatial Data Infrastructure Strategic Plan; Comment Request

    Science.gov (United States)

    2013-08-02

    ... geospatial data in the United States. The FGDC operates under the authority of Office of Management and....'' Executive Order 12906 describes the NSDI as ``the technology, policies, standards, and human resources....S. Geological Survey Draft National Spatial Data Infrastructure Strategic Plan; Comment...

  6. The competitive advantage of nations: the importance of the national environment for strategic management in the EC

    OpenAIRE

    Bosch, Frans; Elfring, Tom; Wolf, Peter

    1991-01-01

    textabstractSummary: In this paper we investigate the usefulness for strategic management of Porter's framework of analysis of the competitive advantage of nations in particular regarding the importance of the changing national environment within the EC. It appears that Porter's framework - supplemented with contributions from the Industrial Organization field and with special attention to the growing importance of the service sector and the particular characteristics of services - can indeed...

  7. Strategic Analysis on Objectives of National Grain Security

    Institute of Scientific and Technical Information of China (English)

    Hong; YANG

    2015-01-01

    Price of global agricultural products rises with great fluctuation. China’s food price also increases constantly. This leads to high concern of both at home and abroad for food and grain security. On the basis of making an overall analysis on current situation of grain security and making judgment on future grain security in China,this paper analyzed objectives,strategies and policies of national grain security in the new period. Finally,it came up with strategies and policy recommendations for improving agricultural production and guaranteeing national grain security.

  8. Strategic plan strategy of the Oak Ridge National Laboratory Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    This report provides information about the use of an integrated strategic plan, strategy, and life-cycle baseline in the long range planning and risk process employed by the environmental restoration program at the Oak Ridge National Laboratory (ORNL). Long-range planning is essential because the ER Program encompasses hundreds of sites; will last several decades; and requires complex technology, management, and policy. Long-range planning allows a focused, cost-effective approach to identify and meet Program objectives. This is accomplished through a strategic plan, a strategy, and a life-cycle baseline. This long-range methodology is illustrated below.

  9. Enhancing consultating services to address national demands of strategic importance

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ As China's top advisory body in science and technology (S&T), over the past four years, CAS has completed nearly 60 consultative reports by pooling the collective wisdom of prestigious scientists across China. Focusing on issues related to the national drive for a comprehensive, balanced and sustainable social- economic development and major S&T strategies, these reports offered scientific insights for decision-making of the central authorities and attracted their close attention.

  10. Strategic regulation of a multi-national banking industry

    OpenAIRE

    Dalen, Dag Morten; Olsen, Trond E.

    2002-01-01

    This paper focuses on the consequences of cross-border banking and entry of multi-national bank (MNB) subsidiaries for banking supervision and regulation. When a MNB expands internationally with subsidiaries, the MNB operates under the legislation of several countries - both the home country and the host countries. Although these countries have agreed upon minimum standards and supervisory principles, such as in the EU directives or the Basle Accords, substantial degrees of freedom are still ...

  11. Australian Strategic Approaches to Managing National and State Diversity

    OpenAIRE

    Lesleyanne Hawthorne

    2015-01-01

    Australia is a global exemplar of nation-building through government planned and administered skilled, family and humanitarian migration programs. By 2011 26% of the population were immigrants, at a time when extraordinary linguistic, religious, racial and cultural diversity were evident. The federal government’s role since the 1901 establishment of the Commonwealth of Australia has spanned migration policy formation, selection, admission, compliance and naturalization functions. The settleme...

  12. Antiviral Drugs: Seasonal Flu

    Centers for Disease Control (CDC) Podcasts

    2010-09-29

    In this podcast, Dr. Joe Bresee explains the nature of antiviral drugs and how they are used for seasonal flu.  Created: 9/29/2010 by National Center for Immunization and Respiratory Diseases (NCIRD).   Date Released: 9/29/2010.

  13. Australian Strategic Approaches to Managing National and State Diversity

    Directory of Open Access Journals (Sweden)

    Lesleyanne Hawthorne

    2015-11-01

    Full Text Available Australia is a global exemplar of nation-building through government planned and administered skilled, family and humanitarian migration programs. By 2011 26% of the population were immigrants, at a time when extraordinary linguistic, religious, racial and cultural diversity were evident. The federal government’s role since the 1901 establishment of the Commonwealth of Australia has spanned migration policy formation, selection, admission, compliance and naturalization functions. The settlement responsibilities of the eight state and territory governments have also grown – a process facilitated by generally amicable federal – subnational relations. Within this context this article describes contemporary Australian approaches to managing linguistic, religious and artistic diversity, comparing federal and state government roles in a period associated with significant multicultural challenges.

  14. National Forestry Research Plan and Strategic Plan of the Agricultural Science and Technology Program (Colciencias

    Directory of Open Access Journals (Sweden)

    Mónica María Baquero Parra

    2011-06-01

    Full Text Available This paper aims to share the national research priorities in agriculture and forestry areas with the scientific community, based on the lines of research identified by the Agricultural Science and Technology Program for the 2010-2019 Strategic Plans by Colciencias. The Strategic Agriculture Plan has determined that the research priorities are Colombia to manage the supply chain, nutrition, rural poverty, quality and innocuousness, as well as the slow production transformation: cost of opportunity and insufficient, decontextualized research. Each of the aforementioned problems is briefly described in the document. As far as the National Plan of Forestry Research is concerned, the following three main topics were suggested: to strengthen a national genetic improvement of tree species that contribute to productivity and the increase of environmental services; to identify and characterize areas, species and potential products for reforestation programs; and to identify species, arrangements and densities that optimize the goods that may be obtained from a forest plantation and its environmental services for the top priority social and agro-ecological conditions of the country. The information regarding the two National Strategic Plans is expected to be disclosed during the first semester of 2011, so that the Administrative Department of Science, Technology and Innovation (Colciencias can support the research projects that meet the expectations of the identified priorities.

  15. Strategic environmental safety inspection for the National disposal program. Description of the inspection volume. Documentation for the scoping team

    International Nuclear Information System (INIS)

    The Strategic environmental safety inspection for the National disposal program covers the following topics: Legal framework: determination of the requirement for an environmental inspection program, coordination of the scoping team into the overall context; environmental targets; approach for assessment and evaluation of environmental impact, description of the inspection targets for the strategic environmental inspection; consideration of alternatives.

  16. Anthrax vaccine as a component of the strategic national stockpile: a dilemma for Homeland Security

    OpenAIRE

    Rempfer, Thomas L.

    2009-01-01

    CHDS State/Local The author explains how past problems with the Defense Department anthrax vaccine currently affect Department of Homeland Security and Department of Health and Human Services policy. The departments included the BioThrax® anthrax vaccine in the Strategic National Stockpile following the 2001 anthrax letter attacks. According to the Federal Bureau of Investigation, the vaccine's "failing" status possibly motivated the letter attacks to create demand for the vaccine. This ...

  17. Executive summary of the Strategic Plan for National Institutes of Health Obesity Research.

    Science.gov (United States)

    Spiegel, Allen M; Alving, Barbara M

    2005-07-01

    The Strategic Plan for National Institutes of Health (NIH) Obesity Research is intended to serve as a guide for coordinating obesity research activities across the NIH and for enhancing the development of new efforts based on identification of areas of greatest scientific opportunity and challenge. Developed by the NIH Obesity Research Task Force with critical input from external scientists and the public, the Strategic Plan reflects a dynamic planning process and presents a multidimensional research agenda, with an interrelated set of goals and strategies for achieving the goals. The major scientific themes around which the Strategic Plan is framed include the following: preventing and treating obesity through lifestyle modification; preventing and treating obesity through pharmacologic, surgical, or other medical approaches; breaking the link between obesity and its associated health conditions; and cross-cutting topics, including health disparities, technology, fostering of interdisciplinary research teams, investigator training, translational research, and education/outreach efforts. Through the efforts described in the Strategic Plan for NIH Obesity Research, the NIH will strive to facilitate and accelerate progress in obesity research to improve public health. PMID:16002822

  18. APPLICATION OF METHODOLOGY OF STRATEGIC PLANNING IN DEVELOPING NATIONAL PROGRAMMES ON DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Inna NOVAK

    2015-07-01

    Full Text Available Actuality: The main purpose of strategic planning is that long-term interests of sustainable development of a market economy require the use of effective measures of state regulation of economic and social processes. Objective: The aim of the article is determined to analyze the development of strategic planning methodology and practical experience of its application in the design of national development programs. Methods: When writing the article the following research methods were used: analysis and synthesis, target-oriented and monographic. Results: In Ukraine at the level of state and local government authorities strategies of development of branches, regions, cities, etc. are being developed but given the lack of state funding a unified investment strategy of the country is not developed. After analyzing development of the strategic planning methodology and examples of its application in the design of state development programs we identified the need to develop an investment strategy of the state (sectors, regions, etc., as due to defined directions and guidelines of the activity it will increase the investment level in the country and ensure national strategy “Ukraine-2020”.

  19. Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium.

    Science.gov (United States)

    Reis, Steven E; Berglund, Lars; Bernard, Gordon R; Califf, Robert M; Fitzgerald, Garret A; Johnson, Peter C

    2010-03-01

    Advances in human health require the efficient and rapid translation of scientific discoveries into effective clinical treatments; this process, in turn, depends on observational data gathered from patients, communities, and public health research that can be used to guide basic scientific investigation. Such bidirectional translational science, however, faces unprecedented challenges due to the rapid pace of scientific and technological development, as well as the difficulties of negotiating increasingly complex regulatory and commercial environments that overlap the research domain. Further, numerous barriers to translational science have emerged among the nation's academic research centers, including basic structural and cultural impediments to innovation and collaboration, shortages of trained investigators, and inadequate funding.To address these serious and systemic problems, in 2006 the National Institutes of Health created the Clinical and Translational Science Awards (CTSA) program, which aims to catalyze the transformation of biomedical research at a national level, speeding the discovery and development of therapies, fostering collaboration, engaging communities, and training succeeding generations of clinical and translational researchers. The authors report in detail on the planning process, begun in 2008, that was used to engage stakeholders and to identify, refine, and ultimately implement the CTSA program's overarching strategic goals. They also discuss the implications and likely impact of this strategic planning process as it is applied among the nation's academic health centers. PMID:20182119

  20. New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2)

    DEFF Research Database (Denmark)

    Christensen, Henry; Nielsen, Jens Steen; Sørensen, Karina Meden;

    2012-01-01

    Long-term storage of biological samples from patients has become increasingly important in studies of disease control and treatment. The first nationwide Danish diabetes project, ie, The Danish Center for Strategic Research in Type II Diabetes (DD2), aims to improve treatment and the long...... samples from 8-10 patients arrive per day. We have established the first national biobank in Denmark where blood, DNA, and plasma and urine samples from patients with newly diagnosed T2D are systematically collected and stored. This biobank enables sophisticated analysis of genetic variation and response...

  1. Government's impact on the business environment and strategic management : Porter's missing fifth determinant of the competitive advantage of nations?

    NARCIS (Netherlands)

    F.A.J. van den Bosch (Frans); A-P. de Man (Ard-Pieter)

    1994-01-01

    textabstractShould 'government' be a fifth force in Michael Porter's model of the Competitive Advantage of Nations and, if so, what should be the appropriate level of analysis? In the strategic management literature, frameworks explaining the impact of the national environment, and more particularly

  2. The governability of national spatial planning: light instruments and logics of governmental action in strategic urban development

    NARCIS (Netherlands)

    F. Savini

    2013-01-01

    Neo-liberalism and decentralisation are eroding the capacity of central governments to implement their national spatial objectives. National government, with fewer financial and political resources at its disposal, has little power to intervene in strategic urban development, because cities have suf

  3. National cultural values and the evolution of process and outcome discrepancies in international strategic alliances

    DEFF Research Database (Denmark)

    Kumar, Rajesh; Nti, Kofi O

    2004-01-01

    discrepancies that may emerge during the course of an alliance. They argue that national culture affects alliance evolution by influencing partners sensitivity to discrepancy detection , shaping the nature of attributions they make, and by affecting the partners reactions to discrepancies. They focus...... on differences in three value orientations among cultures. activity orientation, mastery over nature, and assumptions about human nature are the value orientations that affect alliance functioning. The author/s argue that alliances are prone to interpretational, attributional, and behavioral conflicts......The article assesses the role played by national cultural values in shaping the evolution of international strategic alliances. The authors build on a systems dynamic model of alliance evolution in which the developmental path of an alliance depends on how the partners manage process and outcome...

  4. Government's impact on the business environment and strategic management: Porter's missing fifth determinant of the competitive advantage of nations?

    OpenAIRE

    Bosch, Frans; Man, Ard-Pieter

    1994-01-01

    textabstractShould 'government' be a fifth force in Michael Porter's model of the Competitive Advantage of Nations and, if so, what should be the appropriate level of analysis? In the strategic management literature, frameworks explaining the impact of the national environment, and more particularly of government, on firms and industries are still in their infancy. Michael Porter's 'The Competitive Advantage of Nations' proposes a new integrative framework consisting of four determinants (the...

  5. The spread and maturation of strategic adaptive management within and beyond South African national parks

    Directory of Open Access Journals (Sweden)

    Stefanie Freitag

    2014-09-01

    Full Text Available Natural resource management is embedded within social-ecological environments and requires decisions to be taken within this broad context, including those that pertain to protected areas. This realization has led to South African National Parks adopting a strategic adaptive management approach to decision making. Through narrative, we show why and how this practice has progressively spread and evolved both within the organization and beyond, over the past two decades. A number of catalytic events and synergies enabled a change from reactive tactical management approaches to more inclusive forward-looking approaches able to embrace system complexity and associated uncertainty and change. We show how this long period of innovation has lead to an increased appreciation for the heterogeneous social-ecological system, and for the importance of constructing relationships and colearning, such that organizational transformation has enabled more legitimate and effective operation within an expanding and diversifying constituency.

  6. Strategic environmental audit for the national waste disposal program; Strategische Umweltpruefung zum Nationalen Entsorgungsprogramm. Umweltbericht fuer die Oeffentlichkeitsbeteiligung

    Energy Technology Data Exchange (ETDEWEB)

    Steinhoff, Mathias; Kallenbach-Herbert, Beate; Claus, Manuel [Oeko-Institut e.V., Darmstadt (Germany); and others

    2015-03-27

    The report on the strategic environmental audit for the national waste disposal program covers the following issues: aim of the study, active factors, environmental objectives; description and evaluation of environmental impact including site selection criteria for final repositories of heat generating radioactive waste, intermediate storage of spent fuel elements and waste from reprocessing plants, disposal of wastes retrieved from Asse II; hypothetical zero variants.

  7. Influenza Round Table: Antiviral Drugs

    Centers for Disease Control (CDC) Podcasts

    2009-11-04

    In this podcast, Dr. Joe Bresee explains the nature of antiviral drugs and how they are used.  Created: 11/4/2009 by National Center for Immunization and Respiratory Diseases (NCIRD).   Date Released: 11/4/2009.

  8. A strategic framework for biodiversity monitoring in South African National Parks

    Directory of Open Access Journals (Sweden)

    Melodie A. McGeoch

    2011-05-01

    Full Text Available Protected areas are under increasing threat from a range of external and internal pressures on biodiversity. With a primary mandate being the conservation of biodiversity, monitoring is an essential component of measuring the performance of protected areas. Here we present a framework for guiding the structure and development of a Biodiversity Monitoring System (BMS for South African National Parks (SANParks. Monitoring activities in the organisation are currently unevenly distributed across parks, taxa and key concerns: they do not address the full array of biodiversity objectives, and have largely evolved in the absence of a coherent, overarching framework. The requirement for biodiversity monitoring in national parks is clearly specified in national legislation and international policy, as well as by SANParks’ own adaptive management philosophy. Several approaches available for categorising the multitude of monitoring requirements were considered in the development of the BMS, and 10 Biodiversity Monitoring Programmes (BMPs were selected that provide broad coverage of higher-level biodiversity objectives of parks. A set of principles was adopted to guide the development of BMPs (currently underway, and data management, resource and capacity needs will be considered during their development. It is envisaged that the BMS will provide strategic direction for future investment in this core component of biodiversity conservation and management in SANParks. Conservation implications: Monitoring biodiversity in protected areas is essential to assessing their performance. Here we provide a coordinated framework for biodiversity monitoring in South African National Parks. The proposed biodiversity monitoring system addresses the broad range of park management plan derived biodiversity objectives.

  9. New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes (DD2

    Directory of Open Access Journals (Sweden)

    Christensen H

    2012-09-01

    Full Text Available Henry Christensen,1 Jens Steen Nielsen,2 Karina Meden Sørensen,3 Mads Melbye,3 Ivan Brandslund1,41Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark; 2The Danish Centre for Strategic Research in Type 2 Diabetes (DD2, Department of Endocrinology M, Diabetes Research Centre, Odense University Hospital, Odense, Denmark; 3Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; 4Institute of Regional Health Research, University of Southern Denmark, Odense, DenmarkAbstract: Long-term storage of biological samples from patients has become increasingly important in studies of disease control and treatment. The first nationwide Danish diabetes project, ie, The Danish Center for Strategic Research in Type II Diabetes (DD2, aims to improve treatment and the long-term outcome of patients with newly diagnosed type 2 diabetes (T2D. The DD2 project includes establishment of a biobank with samples from 50,000 patients with newly diagnosed T2D. This paper describes how blood and urine samples from 10,000 patients per year are collected, handled, and stored. The biobank includes whole blood, DNA, and plasma and urine samples, all frozen at −80°C. Sampling tubes have been standardized and are sent to hospital outpatient clinics and general practitioners where samples are taken, handled, aliquoted, and returned by mail overnight in standardized cryostorage tubes. When received at the biobank, samples are frozen without further treatment. From each patient, 24 cryostorage tubes are stored. Each tube is labeled with a barcode that links the data to other information available in a clinical databank registry. When patients are enrolled in DD2, a questionnaire is filled out and a quality monitoring system ensures that patients, samples, and questionnaires can be linked together at all times. The biobank is located at Vejle Hospital and the Danish National Biobank at Statens Serum Institut. As of the end of March 2012

  10. Strategic environmental assessment and national development plans in Turkey: Towards legal framework and operational procedure

    International Nuclear Information System (INIS)

    National development plans were started to be prepared in Turkey in 1963. These plans are mandatory for public investments and guiding principles for private investments. They have a quality which guides and sets objectives for other plans in the country. Therefore, they can be evaluated as the main reason of successes and failures of sectoral investments or the problems that they cause directly or indirectly. Turkey is undergoing rapid industrialization, urbanization and population growth, thus environmental problems are on the increase. Although Environmental Impact Assessment (EIA) has been applied to individual investments in Turkey since 1993, natural environment has continued to be affected because of human activities. Today, parallel to the developments in the world, it has been discussed that it is necessary to strengthen project-level Environmental Assessment (EA) and to practice Strategic Environmental Assessment (SEA). The interest in SEA, that is, EA at the level of proposed policies, plans and programs has grown significantly since 2000 in the country. Discussions and preparations have started about regulation which provides the legal and institutional framework for SEA in The Ministry of Environment and Forestry. However, since the scientific approach into the subject is very new in Turkey, it will take time to answer the questions about how and in what fields to practice. This research project aims at analyzing the possible practice opportunities of SEA in Turkey and the practicability of SEA into the National Five-Year Development Plan (FYDP) which is assumed at the highest level of planning hierarchy in the country. The research is conducted on two sections. In the first section, procedural approaches to SEA on national development plans are investigated and a framework for these approaches is adapted at the institutional level. In the second section, SEA form for energy sector in the development plans is developed. In this article, the findings

  11. National responses to HIV/AIDS and non-communicable diseases in developing countries: analysis of strategic parallels and differences

    Directory of Open Access Journals (Sweden)

    Tilahun Nigatu Haregu

    2014-04-01

    Full Text Available HIV/AIDS and non-communicable diseases (NCDs epidemics may have many important similarities in their aetiology, pathogenesis and management. Evidence about the similarities and differences between the national responses HIV/AIDS and NCDs is essential for an integrated response. The objective of this study was to examine the parallels and differences between national responses to HIV/AIDS and NCDs in selected developing countries. This study applied a strategic level comparative case study approach as its study design. The main construct was national response to HIV/AIDS and NCDs. The 4 overarching themes were policy response, institutional mechanism, programmatic response and strategic information. Four countries were purposively selected as cases. Data were collected and triangulated from a multiple sources. The focus of analysis included identifying items for comparison, characteristics to be compared, degrees of similarity, and strategic importance of similarities. Analysis of data was qualitative content analysis with within-case, between-case, and across-case comparisons. While the nature of the disease and the contents of national HIV/AIDS and NCD policies are different, the policy processes involved are largely similar. Functional characteristics of programmatic response to HIV/AIDS and NCDs are similar. But the internal constituents are different. Though both HIV and NCDs require both a multi-sectorial response and a national coordination mechanism, the model and the complexity of the coordination are different. Strategic information frameworks for HIV/AIDS and NCDs use similar models. However, the indicators, targets and priorities are different. In conclusion, the national responses between HIV/AIDS and NCDs are largely similar in approaches and functions but different in content.

  12. Distinctive Marketing and Information Technology Capabilities and Strategic Types: A Cross-National Investigation

    NARCIS (Netherlands)

    Song, Michael; Nason, Robert W.; Di Benedetto, Anthony

    2008-01-01

    The authors examine the relationship between strategic type and development of distinctive marketing, market-linking, technology, and information technology (IT) capabilities to implement innovation strategy. They hypothesize that prospectors must build technical and IT capabilities, whereas defende

  13. ACAM2000™: The new smallpox vaccine for United States Strategic National Stockpile

    Directory of Open Access Journals (Sweden)

    Aysegul Nalca

    2010-05-01

    Full Text Available Aysegul Nalca, Elizabeth E ZumbrunCenter for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases (USAMRIID, Fort Detrick, MD, USAAbstract: Smallpox was eradicated more than 30 years ago, but heightened concerns over bioterrorism have brought smallpox and smallpox vaccination back to the forefront. The previously licensed smallpox vaccine in the United States, Dryvax® (Wyeth Laboratories, Inc., was highly effective, but the supply was insufficient to vaccinate the entire current US population. Additionally, Dryvax® had a questionable safety profile since it consisted of a pool of vaccinia virus strains with varying degrees of virulence, and was grown on the skin of calves, an outdated technique that poses an unnecessary risk of contamination. The US government has therefore recently supported development of an improved live vaccinia virus smallpox vaccine. This initiative has resulted in the development of ACAM2000™ (Acambis, Inc.™, a single plaque-purified vaccinia virus derivative of Dryvax®, aseptically propagated in cell culture. Preclinical and clinical trials reported in 2008 demonstrated that ACAM2000™ has comparable immunogenicity to that of Dryvax®, and causes a similar frequency of adverse events. Furthermore, like Dryvax®, ACAM2000™ vaccination has been shown by careful cardiac screening to result in an unexpectedly high rate of myocarditis and pericarditis. ACAM2000™ received US Food and Drug Administration (FDA approval in August 2007, and replaced Dryvax® for all smallpox vaccinations in February 2008. Currently, over 200 million doses of ACAM2000™ have been produced for the US Strategic National Stockpile. This review of ACAM2000™ addresses the production, characterization, clinical trials, and adverse events associated with this new smallpox vaccine.Keywords: smallpox, vaccinia, variola, vaccine, efficacy, safety

  14. Pulsed Power Science and Technology: A Strategic Outlook for the National Nuclear Security Administration (Summary)

    Energy Technology Data Exchange (ETDEWEB)

    Sinars, Daniel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Scott, Kimberly Carole [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Edwards, M. John [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Olson, Russell Teall [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-10-17

    Major advances in pulsed power technology and applications over the last twenty years have expanded the mission areas for pulsed power and created compelling new opportunities for the Stockpile Stewardship Program (SSP). This summary document is a forward look at the development of pulsed power science and technology (PPS&T) capabilities in support of the next 20 years of the SSP. This outlook was developed during a three month long tri-lab study on the future of PPS&T research and capabilities in support of applications to: (1) Dynamic Materials, (2) Thermonuclear Burn Physics and Inertial Confinement Fusion (ICF), and (3) Radiation Effects and Nuclear Survivability. It also considers necessary associated developments in next-generation codes and pulsed power technology as well as opportunities for academic, industry, and international engagement. The document identifies both imperatives and opportunities to address future SSP mission needs. This study was commissioned by the National Nuclear Security Administration (NNSA). A copy of the memo request is contained in the Appendix. NNSA guidance received during this study explicitly directed that it not be constrained by resource limitations and not attempt to prioritize its findings against plans and priorities in other areas of the national weapons program. That prioritization, including the relative balance amongst the three focus areas themselves, must of course occur before any action is taken on the observations presented herein. This unclassified summary document presents the principal imperatives and opportunities identified in each mission and supporting area during this study. Proceeding this area-specific outlook, we discuss a cross-cutting opportunity to increase the shot capacity on the Z pulsed power facility as a near term, cost effective way to broadly impact PPS&T for SSP as well as advancing the science and technology to inform future SSMP milestones over the next 5-10 years. The final page of the

  15. National Responses to HIV/AIDS and Non-Communicable Diseases in Developing Countries: Analysis of Strategic Parallels and Differences.

    Science.gov (United States)

    Haregu, Tilahun Nigatu; Setswe, Geoffrey; Elliott, Julian; Oldenburg, Brian

    2014-03-26

    HIV/AIDS and non-communicable diseases (NCDs) epidemics may have many important similarities in their aetiology, pathogenesis and management. Evidence about the similarities and differences between the national responses HIV/AIDS and NCDs is essential for an integrated response. The objective of this study was to examine the parallels and differences between national responses to HIV/AIDS and NCDs in selected developing countries. This study applied a strategic level comparative case study approach as its study design. The main construct was national response to HIV/AIDS and NCDs. The 4 overarching themes were policy response, institutional mechanism, programmatic response and strategic information. Four countries were purposively selected as cases. Data were collected and triangulated from a multiple sources. The focus of analysis included identifying items for comparison, characteristics to be compared, degrees of similarity, and strategic importance of similarities. Analysis of data was qualitative content analysis with within-case, between-case, and across-case comparisons. While the nature of the disease and the contents of national HIV/AIDS and NCD policies are different, the policy processes involved are largely similar. Functional characteristics of programmatic response to HIV/AIDS and NCDs are similar. But the internal constituents are different. Though both HIV and NCDs require both a multi-sectorial response and a national coordination mechanism, the model and the complexity of the coordination are different. Strategic information frameworks for HIV/AIDS and NCDs use similar models. However, the indicators, targets and priorities are different. In conclusion, the national responses between HIV/AIDS and NCDs are largely similar in approaches and functions but different in content. Significance for public healthThis study explores the parallels and differences between national responses to HIV/AIDS and non-communicable diseases (NCDs). The identified

  16. Strategic Factors Influencing National and Regional Systems of Innovation: A Case of Weaker NSI with Stronger RSI

    Directory of Open Access Journals (Sweden)

    Pir Roshanuddin Shah Rashdi

    2015-04-01

    Full Text Available The issues of relationship between NSI ((National System of Innovation and RSI (Regional System of Innovation are not well reported with innovation policy research. That is, whether the NSI is the system on top of RSI, or the importance of regions make stronger NSIs. Therefore, it raises concern regarding development of strategic relationship between these two. For this, two cases ? Catalonia (Spain and N Ireland (the UK, have been selected based on theoretical sampling. Key economic indicators have been identified and have been quantitatively analyzed. The evidence suggests that strong NSI has positive influence on RSI. In addition to that, the concentration of knowledge and promotion of institutions may be strategically established and then needed resources may be injected to produce high quality human resources. There is, however, need for more comprehensive studies to be conducted in order to validate the results of this research

  17. Promoting Leapfrog Development of Life Sciences to Meet the National Strategic Needs

    Institute of Scientific and Technical Information of China (English)

    Kang Le

    2004-01-01

    @@ Life sciences & bio-technology have a direct bearing on social development, economic growth,food security, the improvement of the people's health and living quality both in urban and rural areas. This article gives an analytic exposition of the nationwide strategic demands and current situation of S&T growth, elucidating the competitive status and developmental dynamics of life sciences and bio-technology at CAS. Based on these, it suggests strategic steps for nurturing a leapfrog development in the aspects of disciplinary layout, construction of a research platform, talent-training etc.

  18. A Strategic Study for the enhancement of national nuclear transparency through the extra-contribution to IAEA

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Byung Wook; Lee, H. M.; Ko, H. S.; Ryu, J. S.; Lee, K. S.; Kim, Y. L.; Kim, K. K.; Park, J. H.; Lee, Y. D

    2007-12-15

    This study suggested the framework and the action plan in order to enhance international transparency and confidence for national nuclear policy and its activities. And direction and strategies for strengthening cooperation with IAEA through various voluntary contribution into IAEA activities, was also investigated as well as long term strategic road map. It is important to strengthen the nuclear diplomacy in order to increase transparency of Korean nuclear activities through the establishment of nation-wide collaborative systems as well as systematic and long term based implementation of positive measures and actions. At the same time, it is also required to strengthen cooperation with IAEA through extra- contribution program into relevant IAEA activities as well as establishing national long term strategies.

  19. A Strategic Study for the enhancement of national nuclear transparency through the extra-contribution to IAEA

    International Nuclear Information System (INIS)

    This study suggested the framework and the action plan in order to enhance international transparency and confidence for national nuclear policy and its activities. And direction and strategies for strengthening cooperation with IAEA through various voluntary contribution into IAEA activities, was also investigated as well as long term strategic road map. It is important to strengthen the nuclear diplomacy in order to increase transparency of Korean nuclear activities through the establishment of nation-wide collaborative systems as well as systematic and long term based implementation of positive measures and actions. At the same time, it is also required to strengthen cooperation with IAEA through extra- contribution program into relevant IAEA activities as well as establishing national long term strategies

  20. Penobscot Indian Nation's Strategic Energy Planning Efficiency on tribal Lands

    Energy Technology Data Exchange (ETDEWEB)

    Sockalexis, Mike; Fields, Brenda

    2006-11-30

    The energy grant provided the resources to evaluate the wind, hydro, biomass, geothermal and solar resource potential on all Penobscot Indian Naiton's Tribal lands. The two objectives address potential renewable energy resources available on tribal lands and energy efficiency measures to be taken after comprehensive energy audits of commercial facilities. Also, a Long Term Strategic Energy Plan was developed along with a plan to reduce high energy costs.

  1. Horizontal and vertical integration-diversification in rural hospitals: a national study of strategic activity, 1983-1988.

    Science.gov (United States)

    Mick, S S; Morlock, L L; Salkever, D; de Lissovoy, G; Malitz, F E; Wise, C G; Jones, A S

    1993-01-01

    This study examines both the magnitude of and factors influencing the adoption of 13 horizontal and vertical integration and diversification strategies in a national sample of 797 U.S. rural hospitals during the period 1983-1988. Using organization theory, hypotheses were posed relating environmental and market factors, geographic location, and hospital characteristics to the adoption of horizontal and vertical integration and diversification. Results indicate that only one of 13 strategies was adopted by more than 50 percent of all rural hospitals during the study period, and that most of the directional hypotheses were not confirmed using Cox's proportional hazards models. In particular, environmental and market factors were unrelated to the strategies studied. Issues of methodology and theory are discussed; however, during an historically turbulent period, both relatively low levels of rural hospital strategic activities and lack of predictive power of the theory suggest caution in relying heavily on a policy for rural hospital survival that is dependent on individual market-oriented strategic behavior.

  2. Public health management of antiviral drugs during the 2009 H1N1 influenza pandemic: a survey of local health departments in California

    Directory of Open Access Journals (Sweden)

    Hunter Jennifer C

    2012-01-01

    Full Text Available Abstract Background The large-scale deployment of antiviral drugs from the Strategic National Stockpile during the 2009 H1N1 influenza response provides a unique opportunity to study local public health implementation of the medical countermeasure dispensing capability in a prolonged event of national significance. This study aims to describe the range of methods used by local health departments (LHDs in California to manage antiviral activities and to gain a better understanding of the related challenges experienced by health departments and their community partners. Methods This research employed a mixed-methods approach. First, a multi-disciplinary focus group of pandemic influenza planners from key stakeholder groups in California was convened in order to generate ideas and identify critical themes related to the local implementation of antiviral activities during the H1N1 influenza response. These qualitative data informed the development of a web-based survey, which was distributed to all 61 LHDs in California for the purpose of assessing the experiences of a representative sample of local health agencies in a large region. Results Forty-four LHDs participated in this study, representing 72% of the local public health agencies in California. While most communities dispensed a modest number of publicly purchased antivirals, LHDs nevertheless drew on their previous work and engaged in a number of antiviral activities, including: acquiring, allocating, distributing, dispensing, tracking, developing guidance, and communicating to the public and clinical community. LHDs also identified specific antiviral challenges presented by the H1N1 pandemic, including: reconciling multiple sources and versions of antiviral guidance, determining appropriate uses and recipients of publicly purchased antivirals, and staffing shortages. Conclusions The 2009 H1N1 influenza pandemic presented an unusual opportunity to learn about the role of local public health

  3. Antiviral Prophylaxis and H1N1

    Centers for Disease Control (CDC) Podcasts

    2011-07-14

    Dr. Richard Pebody, a consultant epidemiologist at the Health Protection Agency in London, UK, discusses the use of antiviral post-exposure prophylaxis and pandemic H1N1.  Created: 7/14/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 7/18/2011.

  4. Tough justice for small nations. How strategic behaviour can influence the enforcement of the Kyoto Protocol

    Energy Technology Data Exchange (ETDEWEB)

    Kallbekken, Steffen; Maestad, Ottar; Westskog, Hege

    2003-07-01

    The paper looks at how strategic considerations may play a role in the decision of whether or not to impose sanctions on Parties who are not in compliance with their commitments to the Kyoto Protocol. A member of the Enforcement Branch might have incentive to vote for sanctions towards one non-compliant country and not another even with the same violation. This implies that a certain composition of the members of the Enforcement Branch could decide to sanction one country and not another for the same relative non-compliance, while another composition might choose differently. We show that the expected effects on world market prices of sanctioning a country is likely to influence the decision of whether to carry out the sanctions or not. We find that it is likely to be easier to sanction countries where sanctions result in minor impacts on world market prices than those where the impacts are larger. Finally we discuss an alternative design of the sanction mechanism in view of our results. (Author)

  5. Tough justice for small nations. How strategic behaviour can influence the enforcement of the Kyoto Protocol

    International Nuclear Information System (INIS)

    The paper looks at how strategic considerations may play a role in the decision of whether or not to impose sanctions on Parties who are not in compliance with their commitments to the Kyoto Protocol. A member of the Enforcement Branch might have incentive to vote for sanctions towards one non-compliant country and not another even with the same violation. This implies that a certain composition of the members of the Enforcement Branch could decide to sanction one country and not another for the same relative non-compliance, while another composition might choose differently. We show that the expected effects on world market prices of sanctioning a country is likely to influence the decision of whether to carry out the sanctions or not. We find that it is likely to be easier to sanction countries where sanctions result in minor impacts on world market prices than those where the impacts are larger. Finally we discuss an alternative design of the sanction mechanism in view of our results. (Author)

  6. Cost-Effective Pavement Performance Management of Indiana's Enhanced National Highway System through Strategic Modification of the Pavement Rehabilitation Treatment Trigger Values

    OpenAIRE

    Noureldin, Menna; Fricker, Jon D; Sinha, Kumares C.

    2015-01-01

    Cost-Effective Pavement Performance Management of Indiana's Enhanced National Highway System through Strategic Modification of the Pavement Rehabilitation Treatment Trigger Values Presented during Session 3: Policy and Funding, moderated by Magdy Mikhail, at the 9th International Conference on Managing Pavement Assets (ICMPA9) in Alexandria, VA. Includes conference paper and PowerPoint slides.

  7. On strategic spatial planning

    Directory of Open Access Journals (Sweden)

    Tošić Branka

    2014-01-01

    Full Text Available The goal of this paper is to explain the origin and development of strategic spatial planning, to show complex features and highlight the differences and/or advantages over traditional, physical spatial planning. Strategic spatial planning is seen as one of approaches in legally defined planning documents, and throughout the display of properties of sectoral national strategies, as well as issues of strategic planning at the local level in Serbia. The strategic approach is clearly recognized at the national and sub-national level of spatial planning in European countries and in our country. It has been confirmed by the goals outlined in documents of the European Union and Serbia that promote the grounds of territorial cohesion and strategic integrated planning, emphasizing cooperation and the principles of sustainable spatial development. [Projekat Ministarstva nauke Republike Srbije, br. 176017

  8. Ophthalmic antiviral chemotherapy : An overview

    Directory of Open Access Journals (Sweden)

    Athmanathan Sreedharan

    1997-01-01

    Full Text Available Antiviral drug development has been slow due to many factors. One such factor is the difficulty to block the viral replication in the cell without adversely affecting the host cell metabolic activity. Most of the antiviral compounds are analogs of purines and pyramidines. Currently available antiviral drugs mainly inhibit viral nucleic acid synthesis, hence act only on actively replicating viruses. This article presents an overview of some of the commonly used antiviral agents in clinical ophthalmology.

  9. Strategic Entrepreneurship

    OpenAIRE

    Peter G. Klein; Jay B. Barney; Nicolai J. Foss

    2012-01-01

    Strategic entrepreneurship is a newly recognized field that draws, not surprisingly, from the fields of strategic management and entrepreneurship. The field emerged officially with the 2001 special issue of the Strategic Management Journal on “strategic entrepreneurship”; the first dedicated periodical, the Strategic Entrepreneurship Journal, appeared in 2007. Strategic entrepreneurship is built around two core ideas. (1) Strategy formulation and execution involves attributes that are fundame...

  10. E-Learning in India: The Role of National Culture and Strategic Implications

    Science.gov (United States)

    Rao, Pramila

    2011-01-01

    Purpose: The primary purpose of this research paper is to understand the role of national cultural dimensions on e-learning practices in India. India is considered a major player in the world economy today. US multinationals are significantly increasing their presence in India and understanding cultural preferences will help global companies…

  11. Stimulating the development of national Streptococcus suis guidelines in Viet Nam through a strategic research partnership

    Science.gov (United States)

    Wertheim, Heiman; Ha, Nguyen Hong; Trung, Nguyen Vu; Trinh, Dao Tuyet; Taylor, Walter; Ha, Nguyen Minh; Lien, Trinh Thi Minh; Farrar, Jeremy; Van Kinh, Nguyen

    2010-01-01

    Abstract Problem Streptococcus suis is a common cause of adult bacterial meningitis in Viet Nam, and possibly other parts of Asia, yet this disabling infection has been largely neglected. Prevention, diagnosis and treatment are relatively straightforward and affordable but, in early 2007, no national diagnostic, case management or prevention guidelines existed in Viet Nam. Approach Enhanced detection of S. suis infections was established in 2007 as part of a collaborative research programme between the National Hospital for Tropical Diseases, a key national hospital with very close links to the Ministry of Health, and a research group affiliated with Oxford University based in Viet Nam. The results were reported directly to policy-makers at the Ministry of Health. Local setting Viet Nam is a low-income country with a health-care system that has seen considerable improvements and increased autonomy. However, parts of the system remain fairly centralized the Ministry of Health. Relevant changes Following the improved detection and reporting of S. suis cases, the Ministry of Health issued guidance to all hospitals in Viet Nam on the clinical and laboratory diagnosis, treatment and prevention of S. suis. A public health laboratory diagnostic service was established at the National Institute of Hygiene and Epidemiology and training courses were conducted for clinicians and microbiologists. Ministry of Health guidance on surveillance and control of communicable diseases was updated to include a section on S. suis. Lessons learnt Research collaborations can efficiently inform and influence national responses if they are well positioned to reach policy-makers. PMID:20539860

  12. Assessing the integration of Twitter into the strategic operations of sporting organisations: the case of national governing bodies for sports in England

    Directory of Open Access Journals (Sweden)

    Simon Chadwick

    2013-01-01

    Full Text Available Twitter, a social media application, has opened up communicative avenues for many stakeholders in the sports industry. The pervasive and rapid emergence of Twitter has given sports business and management researchers an opportunity to explore the strategic exploitation of the application by all kinds of sporting organisations. The purpose of this paper is to assess how sporting organisations’ social media content helps them achieve their strategic goals in terms of engagement and persuasion. To this end, the paper empirically examines how nine national governing bodiesfor various sports in England use Twitter. The study’s results accentuate the opportunities that these organisations have to use Twitter to achieve their ultimate goal of increasing participation in their respective sports. Accordingly, the paper recommends that these sporting organisations adopt proactive approaches to the way they use social media/networking and integrate Twitter into their strategic operations.

  13. Constructing a strategic, national resource: European policies and the up-scaling of water services in the Algarve, Portugal.

    Science.gov (United States)

    Thiel, Andreas

    2010-07-01

    Water management has been significantly reshaped throughout recent decades in Europe and worldwide. Vivid examples of this restructuring include Southern European coastal zones which have been transformed into the European "pleasure periphery" over the last 40 years, requiring significant changes in water service provision. Taking it as an illustrative case of the Southern European coastal freshwater crisis and the way different European Member States have dealt with it, the article provides an account of the Algarve, indicative of typical Portuguese dynamics, and compares it with developments in other European countries. Expanding demands on water services in this region led to a crisis situation throughout the nineties, which was resolved by shifting physical infrastructures and competencies to the supra-local level. The re-scaling of water management was instrumental to expanding national control over the sector at the expense of local authorities and privatization. The national level used European funds and regulations to re-configure the institutional and infrastructure set-up in order to provide for tourism and agricultural expansion. Quality tourism was constructed as a decentral, hegemonic state spatial project, with the Algarvian's entire water resource base being put at its disposal. The solution found illustrates a modified version of the supply side and surface water oriented "hydraulic paradigm" in Portugal: geared towards tourism and urban areas and the maintenance of irrigation agriculture. Delays in infrastructures, ideological preferences, maintaining national control over strategic water services and territoriality contributed towards the construction of water services as part of this hegemonic state spatial strategy for tourism expansion.

  14. Building the strategic national stockpile through the NIAID Radiation Nuclear Countermeasures Program.

    Science.gov (United States)

    Rios, Carmen I; Cassatt, David R; Dicarlo, Andrea L; Macchiarini, Francesca; Ramakrishnan, Narayani; Norman, Mai-Kim; Maidment, Bert W

    2014-02-01

    The possibility of a public health radiological or nuclear emergency in the United States remains a concern. Media attention focused on lost radioactive sources and international nuclear threats, as well as the potential for accidents in nuclear power facilities (e.g., Windscale, Three Mile Island, Chernobyl, and Fukushima) highlight the need to address this critical national security issue. To date, no drugs have been licensed to mitigate/treat the acute and long-term radiation injuries that would result in the event of large-scale, radiation, or nuclear public health emergency. However, recent evaluation of several candidate radiation medical countermeasures (MCMs) has provided initial proof-of-concept of efficacy. The goal of the Radiation Nuclear Countermeasures Program (RNCP) of the National Institute of Allergy and Infectious Diseases (National Institutes of Health) is to help ensure the government stockpiling of safe and efficacious MCMs to treat radiation injuries, including, but not limited to, hematopoietic, gastrointestinal, pulmonary, cutaneous, renal, cardiovascular, and central nervous systems. In addition to supporting research in these areas, the RNCP continues to fund research and development of decorporation agents targeting internal radionuclide contamination, and biodosimetry platforms (e.g., biomarkers and devices) to assess the levels of an individual's radiation exposure, capabilities that would be critical in a mass casualty scenario. New areas of research within the program include a focus on special populations, especially pediatric and geriatric civilians, as well as combination studies, in which drugs are tested within the context of expected medical care management (e.g., antibiotics and growth factors). Moving forward, challenges facing the RNCP, as well as the entire radiation research field, include further advancement and qualification of animal models, dose conversion from animal models to humans, biomarker identification, and

  15. Strategic Adaptation

    DEFF Research Database (Denmark)

    Andersen, Torben Juul

    2015-01-01

    This article provides an overview of theoretical contributions that have influenced the discourse around strategic adaptation including contingency perspectives, strategic fit reasoning, decision structure, information processing, corporate entrepreneurship, and strategy process. The related...... concepts of strategic renewal, dynamic managerial capabilities, dynamic capabilities, and strategic response capabilities are discussed and contextualized against strategic responsiveness. The insights derived from this article are used to outline the contours of a dynamic process of strategic adaptation....... This model incorporates elements of central strategizing, autonomous entrepreneurial behavior, interactive information processing, and open communication systems that enhance the organization's ability to observe exogenous changes and respond effectively to them....

  16. Ionospheric Disturbances Originating From Tropospheric and Ground Activities: A new Strategic Research Program at the Los Alamos National Laboratory

    Science.gov (United States)

    Shao, X. M.

    2015-12-01

    It has been increasingly recognized and observed that activities within the troposphere, either natural (e.g., thunderstorm, earthquake, volcano) or anthropogenic (e.g., explosion above or below ground), can substantially disturb the ionosphere in the forms of atmosphere gravity wave, infrasonic acoustic wave, and electric-field-induced ionospheric chemical reaction. These disturbances introduce plasma density variations in the ionosphere that adversely distort the transionospheric radio signals for communication, navigation, surveillance, and other national security missions. A new three-year strategic research program has been initiated at LANL in FY16 to investigate, understand, and characterize the interwoven dynamic and electrodynamic coupling processes from the source in the troposphere to the disturbances in the ionosphere via comprehensive observation and model simulation. The planned study area is chosen to be over the US Great Plains where severe thunderstorms occur frequently and where the necessary atmospheric and ionospheric observations are conducted routinely. In this presentation, we will outline our program plan, technical approaches, and scientific goals, and will discuss opportunities of possible inter-institute collaborations.

  17. Matching the needs of a nation: The strategic roles of indicators for decisionmaking

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, P.J. [Universiti Kebangsaan Malaysia, Selangor (Malaysia)

    1996-12-31

    Indicators are important tools for communicating and making accessible scientific and technical information to policymakers and the general public. They therefore play an important role in transforming information into action. Worldwide, many initiatives are underway to construct indicators for a variety of purposes, including those for reporting on sustainable development. This paper briefly describes the attempts made so far, but stresses that the users of the indicators should play a greater role in indicator construction. In developing countries, a substantial lack of data has meant that specific policy formulation may develop without adequate technical input. In developed countries also, data gaps may hinder policy formulation, implementation, and evaluation. However, the development of indicators as tools to assist in the management of hazardous wastes and toxic chemicals is still in the early stages of formulation. A more imaginative program of indicators and indices is required, where targets are well defined and the users clearly identified to assist in decision making, especially at the local and national levels. A broader range of pressure indicators, beyond hazardous wastes, is proposed to integrate toxic chemicals, emissions, and environmental and human health impacts. 39 refs., 3 figs.

  18. Oak Ridge National Lebroatory Liquid&Gaseous Waste Treatment System Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    Van Hoesen, S.D.

    2003-09-09

    Excellence in Laboratory operations is one of the three key goals of the Oak Ridge National Laboratory (ORNL) Agenda. That goal will be met through comprehensive upgrades of facilities and operational approaches over the next few years. Many of ORNL's physical facilities, including the liquid and gaseous waste collection and treatment systems, are quite old, and are reaching the end of their safe operating life. The condition of research facilities and supporting infrastructure, including the waste handling facilities, is a key environmental, safety and health (ES&H) concern. The existing infrastructure will add considerably to the overhead costs of research due to increased maintenance and operating costs as these facilities continue to age. The Liquid Gaseous Waste Treatment System (LGWTS) Reengineering Project is a UT-Battelle, LLC (UT-B) Operations Improvement Program (OIP) project that was undertaken to develop a plan for upgrading the ORNL liquid and gaseous waste systems to support ORNL's research mission.

  19. Strategic Energy Planning (Area 1) Consultants Reports to Citizen Potawatomi Nation Federally Recognized Indian Tribe

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Marvin; Bose, James; Beier, Richard; Chang, Young Bae

    2004-12-01

    The assets that Citizen Potawatomi Nation holds were evaluated to help define the strengths and weaknesses to be used in pursuing economic prosperity. With this baseline assessment, a Planning Team will create a vision for the tribe to integrate into long-term energy and business strategies. Identification of energy efficiency devices, systems and technologies was made, and an estimation of cost benefits of the more promising ideas is submitted for possible inclusion into the final energy plan. Multiple energy resources and sources were identified and their attributes were assessed to determine the appropriateness of each. Methods of saving energy were evaluated and reported on and potential revenue-generating sources that specifically fit the tribe were identified and reported. A primary goal is to create long-term energy strategies to explore development of tribal utility options and analyze renewable energy and energy efficiency options. Associated goals are to consider exploring energy efficiency and renewable economic development projects involving the following topics: (1) Home-scale projects may include construction of a home with energy efficiency or renewable energy features and retrofitting an existing home to add energy efficiency or renewable energy features. (2) Community-scale projects may include medium to large scale energy efficiency building construction, retrofit project, or installation of community renewable energy systems. (3) Small business development may include the creation of a tribal enterprise that would manufacture and distribute solar and wind powered equipment for ranches and farms or create a contracting business to include energy efficiency and renewable retrofits such as geothermal heat pumps. (4) Commercial-scale energy projects may include at a larger scale, the formation of a tribal utility formed to sell power to the commercial grid, or to transmit and distribute power throughout the tribal community, or hydrogen production

  20. Advancing Earth System Science Literacy and Preparing the Future Geoscience Workforce Through Strategic Investments at the National Science Foundation (Invited)

    Science.gov (United States)

    Karsten, J. L.; Patino, L. C.; Rom, E. L.; Weiler, C. S.

    2010-12-01

    The National Science Foundation (NSF) is an independent federal agency created 60 years ago by the U.S. Congress "to promote the progress of science; to advance the national health, prosperity, and welfare; to secure the national defense…" NSF is the primary funding agency in the U.S. to support basic, frontier research across all fields in science, engineering, and education, except for medical sciences. With a FY 2011 budget request of more than $955 million, the NSF Directorate for Geosciences (GEO) is the principle source of federal funding for university-based fundamental research in the geosciences and preparation of the next generation of geoscientists. Since its inception, GEO has supported the education and training of a diverse and talented pool of future scientists, engineers, and technicians in the Earth, Ocean, Atmospheric and Geospatial Sciences sub-fields, through support of graduate research assistants, post-doctoral fellows, and undergraduate research experiences. In the late 1990’s and early 2000’s, GEO initiated several programs that expanded these investments to also support improvements in pre-college and undergraduate geoscience education through a variety of mechanisms (e.g., professional development support for K-12 teachers, development of innovative undergraduate curricula, and scientist-mentored research experiences for elementary and secondary students). In addition to GEO’s Geoscience Education (GeoEd), Opportunities for Enhancing Diversity in the Geosciences (OEDG), Global Learning and Observations to Benefit the Environment (GLOBE), and Geoscience Teacher Training (GEO-Teach) programs, GEO participates in a number of cross-Foundation programs, including the Research Experiences for Undergraduates (REU), Integrative Graduate Education and Research Traineeship (IGERT), Ethics Education in Science and Engineering (EESE), NSF Graduate STEM Fellows in K-12 Education (GK-12), and Partnerships for International Research and Education

  1. The quality and effectiveness of Strategic Environmental Assessment (SEA as a decision-aiding tool for national park expansion—the greater Addo Elephant National Park case study

    Directory of Open Access Journals (Sweden)

    F. Retief

    2006-12-01

    Full Text Available Internationally South Africa is regarded as a leading developing country in the application of SEA. Research also indicates that the conservation sector within South Africa has been particularly prominent in exploring its application. However, very little empirical research has been conducted to learn from practice and to establish the added value of SEA to strategic decision making. To address this gap in knowledge the paper explores the input quality and output effectiveness of the greater Addo Elephant National Park SEA. The results show that the SEA achieved average to good input quality and output effectiveness performance, respectively. A number of lessons were learned for the application of SEA to future park expansion initiatives. These relate to the timing of the SEA, addressing social impacts, setting of boundaries as well as dealing with scale. The research results concluded that SEA made valuable contributions to decision making and could be considered an important decision-aiding tool for the conservation sector. To take the debate forward and to benchmark best practice it is proposed that further comparative performance evaluation research of multiple SEA case studies within the conservation sector be conducted.

  2. Translating a National Laboratory Strategic Plan into action through SLMTA in a district hospital laboratory in Botswana

    Directory of Open Access Journals (Sweden)

    Keoratile Ntshambiwa

    2014-09-01

    Full Text Available Background: The Ministry of Health (MOH of Botswana adopted Strengthening Laboratory Management Toward Accreditation (SLMTA, a structured quality improvement programme, as a key tool for the implementation of quality management systems in its public health laboratories. Coupled with focused mentorship, this programme aimed to help MOH achieve the goals of the National Laboratory Strategic Plan to provide quality and timely clinical diagnosis.Objectives: This article describes the impact of implementing SLMTA in Sekgoma Memorial Hospital Laboratory (SMHL in Serowe, Botswana.Methods: SLMTA implementation in SMHL included trainings, improvement projects, site visits and focused mentorship. To measure progress, audits using the Stepwise Laboratory Quality Improvement Process Towards Accreditation (SLIPTA checklist were conducted at baseline and exit of the programme, with scores corresponding to a zero- to five-star scale.Turnaround times and customer satisfaction were tracked.Results: The laboratory scored 53% (zero stars at the baseline audit and 80% (three stars at exit. Nearly three years later, the laboratory scored 85% (four stars in an official audit conducted by the African Society for Laboratory Medicine. Turnaround times became shorter after SLMTA implementation, with reductions ranging 19% to 52%; overall patient satisfaction increased from 56% to 73%; and clinician satisfaction increased from 41% to 72%. Improvements in inventory management led to decreases in discarded reagents, reducinglosses from US $18 000 in 2011 to $40 in 2013.Conclusion: The SLMTA programme contributed to enhanced performance of the laboratory,which in turn yielded potential positive impacts for patient care at the hospital.

  3. Strategic Leadership

    Science.gov (United States)

    Davies, Barbara; Davies, Brent

    2004-01-01

    This article explores the nature of strategic leadership and assesses whether a framework can be established to map the dimensions of strategic leadership. In particular it establishes a model which outlines both the organizational abilities and the individual characteristics of strategic leaders.

  4. Strategic Entrepreneurship

    DEFF Research Database (Denmark)

    Klein, Peter G.; Barney, Jay B.; Foss, Nicolai Juul

    periodical, the Strategic Entrepreneurship Journal, appeared in 2007. Strategic entrepreneurship is built around two core ideas. (1) Strategy formulation and execution involves attributes that are fundamentally entrepreneurial, such as alertness, creativity, and judgment, and entrepreneurs try to create...... explains the specific links between strategy and entrepreneurship, reviews the emergence and development of the strategic entrepreneurship field, and discusses key implications and applications....

  5. A Strategic Vision for NSF Investments in Antarctic and Southern Ocean Research: Recommendations of a New Study from the National Academes of Sciences, Engineering, and Medicine.

    Science.gov (United States)

    Weller, R. A.; Bell, R. E.; Geller, L.

    2015-12-01

    A Committee convened by the National Academies of Sciences, Engineering, and Medicine carried out a study (at the request of NSF's Division of Polar Programs) to develop a strategic vision for the coming decade of NSF's investments in Antarctic and Southern Ocean research. The study was informed by extensive efforts to gather ideas from researchers across the United States. This presentation will provide an overview of the Committee's recommendations—regarding an overall strategic framework for a robust U.S. Antarctic program, regarding the specific areas of research recommended as highest priority for NSF support, and regarding the types of infrastructure, logistical support, data management, and other critical foundations for enabling and adding lasting value to the proposed research .

  6. River management under transformation: The emergence of strategic adaptive management of river systems in the Kruger National Park

    Directory of Open Access Journals (Sweden)

    Sharon Pollard

    2011-05-01

    Full Text Available Protected areas such as the Kruger National Park (KNP face many management challenges, of which ensuring a healthy flow of rivers into the park is one of the most important. Although previous management policies isolated the KNP from its neighbours, this position has changed as the KNP seeks to negotiate a respected ‘place’ for water and conservation in a competitive environment. A major catalyst for this re-orientation has been the response from the KNP to the growing water crisis where its position needed to be seen within the wider catchment and policy context in South Africa. This paper presents an overview of the transforming management practices of the KNP in a changing political, socio-economic and environmental context, through the lens of water resources. We show that the KNP management model moved beyond inward-looking, isolationist policies to adopt responsivity to major change factors. The new approach was applied first in the sphere of river management in the KNP after which it spread to other domains such as fire and game management. It explicitly incorporates an experimental–reflexive orientation and considers management as a process of learningby- doing. This paper strives to review the transformation since the onset of explicit adaptive management of these rivers. The development of a new stewardship, based on a stakeholdercentred vision and on learning-focused management, has been a main achievement for the KNP. A closer partnership between researchers, managers and field staff, supported with buyin and co-learning, has led to a management framework based on a clear vision informed by stakeholder involvement, an objectives hierarchy, a scoping of management options, a monitoring system and a reflective evaluation process with feedback loops. Although developed through a focus on rivers, the framework can be embraced for the management of ecosystems as a whole.Conservation implications: The explicit adoption of strategic

  7. Antiviral immunity in amphibians.

    Science.gov (United States)

    Chen, Guangchun; Robert, Jacques

    2011-11-01

    Although a variety of virus species can infect amphibians, diseases caused by ranaviruses ([RVs]; Iridoviridae) have become prominent, and are a major concern for biodiversity, agriculture and international trade. The relatively recent and rapid increase in prevalence of RV infections, the wide range of host species infected by RVs, the variability in host resistance among population of the same species and among different developmental stages, all suggest an important involvement of the amphibian immune system. Nevertheless, the roles of the immune system in the etiology of viral diseases in amphibians are still poorly investigated. We review here the current knowledge of antiviral immunity in amphibians, focusing on model species such as the frog Xenopus and the salamander (Ambystoma tigrinum), and on recent progress in generating tools to better understand how host immune defenses control RV infections, pathogenicity, and transmission.

  8. The neoliberalisation of strategic spatial planning

    DEFF Research Database (Denmark)

    Olesen, Kristian

    2014-01-01

    Strategic spatial planning practices have recently taken a neoliberal turn in many northwestern European countries. This neoliberalisation of strategic spatial planning has materialised partly in governance reforms aiming to reduce or abolish strategic spatial planning at national and regional...... scales, and partly through the normalisation of neoliberal discourses in strategic spatial planning processes. This paper analyses the complex relationship, partly of unease and partly of coevolution, between neoliberalism and strategic spatial planning. Furthermore, the paper discusses the key...... challenges for strategic spatial planning in the face of neoliberalism and argues for a need to strengthen strategic spatial planning’s critical dimension....

  9. 77 FR 54615 - Strategic Management Program; Fiscal Year 2013-2016 Strategic Plan

    Science.gov (United States)

    2012-09-05

    ... SAFETY BOARD Strategic Management Program; Fiscal Year 2013-2016 Strategic Plan AGENCY: National... Board, 490 L'Enfant Plaza SW., Washington, DC 20594. Attn: MD-1, Strategic Management Program. FOR FURTHER INFORMATION CONTACT: Agency contact, Shamicka Fulson, Program Manager, Strategic...

  10. Antiviral Drug Research Proposal Activity

    Directory of Open Access Journals (Sweden)

    Lisa Injaian

    2011-03-01

    Full Text Available The development of antiviral drugs provides an excellent example of how basic and clinical research must be used together in order to achieve the final goal of treating disease. A Research Oriented Learning Activity was designed to help students to better understand how basic and clinical research can be combined toward a common goal. Through this project students gained a better understanding of the process of scientific research and increased their information literacy in the field of virology. The students worked as teams to research the many aspects involved in the antiviral drug design process, with each student becoming an "expert" in one aspect of the project. The Antiviral Drug Research Proposal (ADRP culminated with students presenting their proposals to their peers and local virologists in a poster session. Assessment data showed increased student awareness and knowledge of the research process and the steps involved in the development of antiviral drugs as a result of this activity.

  11. Emerging antiviral drugs.

    Science.gov (United States)

    De Clercq, Erik

    2008-09-01

    Foremost among the newly described antiviral agents that may be developed into drugs are, for the treatment of human papilloma virus (HPV) infections, cPrPMEDAP; for the treatment of herpes simplex virus (HSV) infections, BAY 57-1293; for the treatment of varicella-zoster virus (VZV) infections, FV-100 (prodrug of Cf 1743); for the treatment of cytomegalovirus (CMV) infections, maribavir; for the treatment of poxvirus infections, ST-246; for the treatment of hepatitis B virus (HBV) infections, tenofovir disoproxil fumarate (TDF) (which in the meantime has already been approved in the EU); for the treatment of various DNA virus infections, the hexadecyloxypropyl (HDP) and octadecyloxyethyl (ODE) prodrugs of cidofovir; for the treatment of orthomyxovirus infections (i.e., influenza), peramivir; for the treatment of hepacivirus infections (i.e., hepatitis C), the protease inhibitors telaprevir and boceprevir, the nucleoside RNA replicase inhibitors (NRRIs) PSI-6130 and R1479, and various non-nucleoside RNA replicase inhibitors (NNRRIs); for the treatment of human immunodeficiency virus (HIV) infections, integrase inhibitors (INIs) such as elvitegravir, nucleoside reverse transcriptase inhibitors (NRTIs) such as apricitabine, non-nucleoside reverse transcriptase inhibitors (NNRTIs) such as rilpivirine and dapivirine; and for the treatment of both HCV and HIV infections, cyclosporin A derivatives such as the non-immunosuppressive Debio-025. PMID:18764719

  12. Emerging antiviral drugs.

    Science.gov (United States)

    De Clercq, Erik

    2008-09-01

    Foremost among the newly described antiviral agents that may be developed into drugs are, for the treatment of human papilloma virus (HPV) infections, cPrPMEDAP; for the treatment of herpes simplex virus (HSV) infections, BAY 57-1293; for the treatment of varicella-zoster virus (VZV) infections, FV-100 (prodrug of Cf 1743); for the treatment of cytomegalovirus (CMV) infections, maribavir; for the treatment of poxvirus infections, ST-246; for the treatment of hepatitis B virus (HBV) infections, tenofovir disoproxil fumarate (TDF) (which in the meantime has already been approved in the EU); for the treatment of various DNA virus infections, the hexadecyloxypropyl (HDP) and octadecyloxyethyl (ODE) prodrugs of cidofovir; for the treatment of orthomyxovirus infections (i.e., influenza), peramivir; for the treatment of hepacivirus infections (i.e., hepatitis C), the protease inhibitors telaprevir and boceprevir, the nucleoside RNA replicase inhibitors (NRRIs) PSI-6130 and R1479, and various non-nucleoside RNA replicase inhibitors (NNRRIs); for the treatment of human immunodeficiency virus (HIV) infections, integrase inhibitors (INIs) such as elvitegravir, nucleoside reverse transcriptase inhibitors (NRTIs) such as apricitabine, non-nucleoside reverse transcriptase inhibitors (NNRTIs) such as rilpivirine and dapivirine; and for the treatment of both HCV and HIV infections, cyclosporin A derivatives such as the non-immunosuppressive Debio-025.

  13. The quality and effectiveness of Strategic Environmental Assessment (SEA) as a decision-aiding tool for national park expansion—the greater Addo Elephant National Park case study

    OpenAIRE

    F. Retief

    2006-01-01

    Internationally South Africa is regarded as a leading developing country in the application of SEA. Research also indicates that the conservation sector within South Africa has been particularly prominent in exploring its application. However, very little empirical research has been conducted to learn from practice and to establish the added value of SEA to strategic decision making. To address this gap in knowledge the paper explores the input quality and output effectiveness of the greater ...

  14. Strategic Responsiveness

    DEFF Research Database (Denmark)

    Pedersen, Carsten; Juul Andersen, Torben

    decision making is often conceived as ‘standing on the two feet’ of deliberate or intended strategic decisions by top management and emergent strategic decisions pursued by lower-level managers and employees. In this view, the paper proposes that bottom-up initiatives have a hard time surfacing...... in hierarchical organizations and that lowerlevel managers and employees, therefore, pursue various strategies to bypass the official strategy processes to act on emerging strategic issues and adapt to changing environmental conditions.......The analysis of major resource committing decisions is central focus in the strategy field, but despite decades of rich conceptual and empirical research we still seem distant from a level of understanding that can guide corporate practices under dynamic and unpredictable conditions. Strategic...

  15. Strategic Forecasting

    DEFF Research Database (Denmark)

    Duus, Henrik Johannsen

    2016-01-01

    Purpose: The purpose of this article is to present an overview of the area of strategic forecasting and its research directions and to put forward some ideas for improving management decisions. Design/methodology/approach: This article is conceptual but also informed by the author’s long contact...... and collaboration with various business firms. It starts by presenting an overview of the area and argues that the area is as much a way of thinking as a toolbox of theories and methodologies. It then spells out a number of research directions and ideas for management. Findings: Strategic forecasting is seen...... as a rebirth of long range planning, albeit with new methods and theories. Firms should make the building of strategic forecasting capability a priority. Research limitations/implications: The article subdivides strategic forecasting into three research avenues and suggests avenues for further research efforts...

  16. Strategic Forecasting

    DEFF Research Database (Denmark)

    Duus, Henrik Johannsen

    2016-01-01

    as a rebirth of long range planning, albeit with new methods and theories. Firms should make the building of strategic forecasting capability a priority. Research limitations/implications: The article subdivides strategic forecasting into three research avenues and suggests avenues for further research efforts......Purpose: The purpose of this article is to present an overview of the area of strategic forecasting and its research directions and to put forward some ideas for improving management decisions. Design/methodology/approach: This article is conceptual but also informed by the author’s long contact...... and collaboration with various business firms. It starts by presenting an overview of the area and argues that the area is as much a way of thinking as a toolbox of theories and methodologies. It then spells out a number of research directions and ideas for management. Findings: Strategic forecasting is seen...

  17. Strategic Arrivals Recommendation Tool Project

    Data.gov (United States)

    National Aeronautics and Space Administration — During the conduct of a NASA Research Announcement (NRA) in 2012 and 2013, the Mosaic ATM team first developed the Strategic Arrivals Recommendation Tool concept,...

  18. H1N1 Flu and Antiviral Drugs

    Centers for Disease Control (CDC) Podcasts

    2009-05-02

    This podcast discusses the use of antiviral drugs for treating and preventing the H1N1 flu virus.  Created: 5/2/2009 by Coordinating Center for Infectious Diseases, National Center for Immunization and Respiratory Diseases, Influenza Division (CCID/NCIRD/ID).   Date Released: 5/2/2009.

  19. Flu Resistance to Antiviral Drug in North Carolina

    Centers for Disease Control (CDC) Podcasts

    2011-12-19

    Dr. Katrina Sleeman, Associate Service Fellow at CDC, discusses resistance to an antiviral flu drug in North Carolina.  Created: 12/19/2011 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 12/19/2011.

  20. Strategic Management

    OpenAIRE

    Vančata, Jan

    2012-01-01

    Strategic management is a process in which managers determine long-lasting direction of the company, set specific targets of performance and develop appropriate strategies to achieve objectives considering all reasonable internal and external factors of the company. Also make concrete steps toward realization through the selected plan. Why is the strategic management important in the company? The answer is quite simple. It assigns a specific role to each person, it leads towards the differenc...

  1. Sexual rights but not the right to health? Lesbian and bisexual women in South Africa's National Strategic Plans on HIV and STIs.

    Science.gov (United States)

    Daly, Felicity; Spicer, Neil; Willan, Samantha

    2016-05-01

    Synergies between securing sexual rights and the right to health have been pursued where there are clear public health gains to be made, such as lowering incidence of HIV and other sexually transmitted infections (STI). South Africa's 1996 Constitution outlawed discrimination on the basis of sexual orientation and promoted the right to health. This qualitative health policy analysis sought to understand why and how interventions to improve sexual health of lesbian and bisexual women and address sexual violence were initially proposed in the HIV & AIDS and STI Strategic Plan for South Africa 2007-2011 and why and how these concerns were deprioritised in the National Strategic Plan (NSP) on HIV, STIs and TB 2012-2016. A conceptual framework considered several determinants of political priority for the inclusion in NSP development in 2007 and 2011 around sexual health concerns of women who have sex with women. This article presents findings from 25 in-depth key informant interviews and document review and highlights results of application of categories for a framework on determinants of political priority for lesbian and bisexual women's issues to be included in South Africa's NSP including: actor power, ideas, political context and issue characteristics. The article demonstrates how the epidemiological and structural drivers of lesbian and bisexual women's vulnerability to HIV and STIs, including sexual violence and other violations of their sexual rights, have been expressed in policy forums and whether this has made an impact on lesbian and bisexual women's ability to claim the right to health. PMID:27578352

  2. Os estudos estratégicos como base reflexiva da defesa nacional Strategic studies as the core discipline of national defense

    Directory of Open Access Journals (Sweden)

    Domício Proença Júnior

    2007-06-01

    Full Text Available O artigo pontua a trajetória dos Estudos Estratégicos desde sua origem para embasar o pleito de sua centralidade em temas afins à Defesa Nacional. Discute o porquê de tal ‘interdisciplina’, a forma cíclica pela qual eles vêm sendo objetos de estudo, ensino e pesquisa em estabelecimentos civis e militares e o resultado capital da centralidade da Teoria da Guerra de Clausewitz para seu desenvolvimento. Apresenta, à guisa de conclusões, um conjunto de preocupações sobre a atualidade dos Estudos Estratégicos.The article discusses Strategic Studies from its beginnings in support of the plea of its central role in National Defense affairs. It discusses why such an ‘interdiscipline’ came into being, the cyclical character of its application in civilian and military education and research and the capital role of Clausewitz’s Theory of War in its development. It shares, as conclusions, some concerns about the current state of Strategic Studies.

  3. Sexual rights but not the right to health? Lesbian and bisexual women in South Africa's National Strategic Plans on HIV and STIs.

    Science.gov (United States)

    Daly, Felicity; Spicer, Neil; Willan, Samantha

    2016-05-01

    Synergies between securing sexual rights and the right to health have been pursued where there are clear public health gains to be made, such as lowering incidence of HIV and other sexually transmitted infections (STI). South Africa's 1996 Constitution outlawed discrimination on the basis of sexual orientation and promoted the right to health. This qualitative health policy analysis sought to understand why and how interventions to improve sexual health of lesbian and bisexual women and address sexual violence were initially proposed in the HIV & AIDS and STI Strategic Plan for South Africa 2007-2011 and why and how these concerns were deprioritised in the National Strategic Plan (NSP) on HIV, STIs and TB 2012-2016. A conceptual framework considered several determinants of political priority for the inclusion in NSP development in 2007 and 2011 around sexual health concerns of women who have sex with women. This article presents findings from 25 in-depth key informant interviews and document review and highlights results of application of categories for a framework on determinants of political priority for lesbian and bisexual women's issues to be included in South Africa's NSP including: actor power, ideas, political context and issue characteristics. The article demonstrates how the epidemiological and structural drivers of lesbian and bisexual women's vulnerability to HIV and STIs, including sexual violence and other violations of their sexual rights, have been expressed in policy forums and whether this has made an impact on lesbian and bisexual women's ability to claim the right to health.

  4. Viral Ancestors of Antiviral Systems

    Directory of Open Access Journals (Sweden)

    Luis P. Villarreal

    2011-10-01

    Full Text Available All life must survive their corresponding viruses. Thus antiviral systems are essential in all living organisms. Remnants of virus derived information are also found in all life forms but have historically been considered mostly as junk DNA. However, such virus derived information can strongly affect host susceptibility to viruses. In this review, I evaluate the role viruses have had in the origin and evolution of host antiviral systems. From Archaea through bacteria and from simple to complex eukaryotes I trace the viral components that became essential elements of antiviral immunity. I conclude with a reexamination of the ‘Big Bang’ theory for the emergence of the adaptive immune system in vertebrates by horizontal transfer and note how viruses could have and did provide crucial and coordinated features.

  5. Viral ancestors of antiviral systems.

    Science.gov (United States)

    Villarreal, Luis P

    2011-10-01

    All life must survive their corresponding viruses. Thus antiviral systems are essential in all living organisms. Remnants of virus derived information are also found in all life forms but have historically been considered mostly as junk DNA. However, such virus derived information can strongly affect host susceptibility to viruses. In this review, I evaluate the role viruses have had in the origin and evolution of host antiviral systems. From Archaea through bacteria and from simple to complex eukaryotes I trace the viral components that became essential elements of antiviral immunity. I conclude with a reexamination of the 'Big Bang' theory for the emergence of the adaptive immune system in vertebrates by horizontal transfer and note how viruses could have and did provide crucial and coordinated features.

  6. Legislation strategic enterprises of machine building industry

    OpenAIRE

    Kotovska, Iryna; Halushchak, Olha Yaropolkivna

    2011-01-01

    The article explores the stages of strategic planning in Ukraine, determined its value for industry in general and engineering industry in particular. We consider the legislative framework that regulates the process of strategic planning at three levels: national, regional and sectoral.Found that the number of strategic documents of various levels increases and decreases the effectiveness of their implementation. The legal framework of strategic planning is not complete and is mostly declarat...

  7. Legislation strategic enterprises of machine building industry

    Directory of Open Access Journals (Sweden)

    Kotovska, Iryna

    2011-11-01

    Full Text Available The article explores the stages of strategic planning in Ukraine, determined its value for industry in general and engineering industry in particular. We consider the legislative framework that regulates the process of strategic planning at three levels: national, regional and sectoral.Found that the number of strategic documents of various levels increases and decreases the effectiveness of their implementation. The legal framework of strategic planning is not complete and is mostly declarative.

  8. EMSL Strategic Plan 2008

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, Allison A.

    2008-08-15

    This Strategic Plan is EMSL’s template for achieving our vision of simultaneous excellence in all aspects of our mission as a national scientific user facility. It reflects our understanding of the long-term stewardship we must work toward to meet the scientific challenges of the Department of Energy and the nation. During the next decade, we will implement the strategies contained in this Plan, working closely with the scientific community, our advisory committees, DOE’s Office of Biological and Environmental Research, and other key stakeholders. This Strategic Plan is fully aligned with the strategic plans of DOE and its Office of Science. We recognize that shifts in science and technology, national priorities, and resources made available through the Federal budget process create planning uncertainties and, ultimately, a highly dynamic planning environment. Accordingly, this Strategic Plan should be viewed as a living document for which we will continually evaluate changing needs and opportunities posed by our stakeholders (i.e., DOE, users, staff, advisory committees), work closely with them to understand and respond to those changes, and align our strategy accordingly.

  9. Forest bird monitoring protocol for strategic habitat conservation and endangered species management on O'ahu Forest National Wildlife Refuge, Island of O'ahu, Hawai'i

    Science.gov (United States)

    Camp, Richard J.; Gorresen, P. Marcos; Banko, Paul C.

    2011-01-01

    This report describes the results of a pilot forest bird survey and a consequent forest bird monitoring protocol that was developed for the O'ahu Forest National Wildlife Refuge, O'ahu Island, Hawai'i. The pilot survey was conducted to inform aspects of the monitoring protocol and to provide a baseline with which to compare future surveys on the Refuge. The protocol was developed in an adaptive management framework to track bird distribution and abundance and to meet the strategic habitat conservation requirements of the Refuge. Funding for this research was provided through a Science Support Partnership grant sponsored jointly by the U.S. Geological Survey (USGS) and the U.S. Fish and Wildlife Service (USFWS).

  10. The National program of the production and use of biodiesel and strategic environmental assessment; O Programa nacional de producao e uso de biodiesel e a avaliacao ambiental estrategica

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Victor Rafael Fernandes [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil)

    2010-07-01

    This work analyzes the use of biodiesel in Brazil under the applied perspective of this renewable fuel in the environmental assessment in the productive chain. It inwards the appearance of biodiesel, its evolution in Brazil and in the world, the structured regulatory framework, beyond these points this work also gives a main focus on the advent of National Program of Production and Usage of Biodiesel (NPPUB - originally PNPUB) and on the defined productive arrangement. It scrutinizes the Environmental Impact Assessment (EIA) and the Strategic Environmental Assessment (SEA), and delimits the pivotal hindrances to the development of biodiesel production sector, claiming to point out all the possible and viable scenarios, profiting the economic development of this activity in harmony with the urgent need to implement Environmentally Safe projects. (author)

  11. Strategic serendipity

    DEFF Research Database (Denmark)

    Knudsen, Gry Høngsmark; Lemmergaard, Jeanette

    2014-01-01

    -of-the-art knowledge and in-depth understanding of the affordances of different communication channels, we discuss the importance of establishing opportunities for serendipity in strategic communication planning. The contribution of the paper is to develop the concept of strategic serendipity and show how......This paper contributes to critical voices on the issue of strategic communication. It does so by exploring how an organisation can seize the moment of serendipity based on careful preparation of its issues management and communication channels. The focus of the study is the media coverage...... of – and communicative responses to – Kopenhagen Fur's campaign The World's Best – but not perfect in both broadcast media (e.g. print and television) and social media, more specifically Facebook. Through understanding how an organisation can plan for and take advantage of the unpredictable through state...

  12. Strategic analysis

    OpenAIRE

    Chládek, Vítězslav

    2012-01-01

    The objective of this Bachelor thesis is to carry out a strategic analysis of a Czech owned limited company, Česky národní podnik s.r.o. This company sells traditional Czech products and manufactures cosmetics and body care products. The first part of the thesis provides theoretical background and methodology that are used later for the strategic analysis of the company. The theory outlined in this paper is based on the analysis of external and internal factors. Firstly the PEST analysis has ...

  13. Strategic analysis

    OpenAIRE

    Bartuňková, Alena

    2008-01-01

    The objective of this Bachelor thesis is to carry out a strategic analysis of a Czech owned limited company, Česky národní podnik s.r.o. This company sells traditional Czech products and manufactures cosmetics and body care products. The first part of the thesis provides theoretical background and methodology that are used later for the strategic analysis of the company. The theory outlined in this paper is based on the analysis of external and internal factors. Firstly the PEST analysis has ...

  14. Strategic Plan for the National Wildlife Refuge System Biological Monitoring Team Pilot Project Fiscal Years 2006-2010

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The U.S. Fish and Wildlife Service National Wildlife Refuge System (NWRS) is the premier system of federal lands set aside primarily for the purpose of conserving...

  15. Strategic Bonding.

    Science.gov (United States)

    Davis, Lynn; Tyson, Ben

    2003-01-01

    Many school buildings are in dire need of renovation, expansion, or replacement. Brief case studies from around the country illustrate the importance of finding out why people vote for or against a construction referendum. Lists recommendations for a strategic campaign. (MLF)

  16. How do national strategic plans for HIV and AIDS in southern and eastern Africa address gender-based violence? A women's rights perspective.

    Science.gov (United States)

    Gibbs, Andrew; Mushinga, Mildred; Crone, E Tyler; Willan, Samantha; Mannell, Jenevieve

    2012-12-15

    Gender-based violence (GBV) is a significant human rights violation and a key driver of the HIV epidemic in southern and eastern Africa. We frame GBV from a broad human rights approach that includes intimate partner violence and structural violence. We use this broader definition to review how National Strategic Plans for HIV and AIDS (NSPs) in southern and eastern Africa address GBV. NSPs for HIV and AIDS provide the national-level framework that shapes government, business, donor, and non-governmental responses to HIV within a country. Our review of these plans for HIV and AIDS suggests that attention to GBV is poorly integrated; few recognize GBV and program around GBV. The programming, policies, and interventions that do exist privilege responses that support survivors of violence, rather than seeking to prevent it. Furthermore, the subject who is targeted is narrowly constructed as a heterosexual woman in a monogamous relationship. There is little consideration of GBV targeting women who have non-conforming sexual or gender identities, or of the need to tackle structural violence in the response to HIV and AIDS. We suggest that NSPs are not sufficiently addressing the human rights challenge of tackling GBV in the response to HIV and AIDS in southern and eastern Africa. It is critical that they do so.

  17. STRATEGIC PRIORITIES FOR INCREASING PHYSICAL ACTIVITY AMONG ADULTS AGE 50 AND OLDER: THE NATIONAL BLUEPRINT CONSENSUS CONFERENCE SUMMARY REPORT

    Directory of Open Access Journals (Sweden)

    Terry Bazzarre

    2003-12-01

    Full Text Available On May 1, 2001, a coalition of national organizations released a major planning document designed to develop a national strategy for the promotion of physically active lifestyles among the mid-life and older adult population. The National Blueprint: Increasing Physical Activity Among Adults Age 50 and Older was developed with input from 46 organizations with expertise in health, medicine, social and behavioral sciences, epidemiology, gerontology/geriatrics, clinical science, public policy, marketing, medical systems, community organization, and environmental issues. The Blueprint notes that, despite a wealth of evidence about the benefits of physical activity for mid-life and older persons, there has been little success in convincing age 50+ Americans to adopt physically active lifestyles. The Blueprint identifies barriers in the areas of research, home and community programs, medical systems, public policy and advocacy, and marketing and communications. In addition to identifying barriers, the Blueprint proposes a number of concrete strategies that could be employed in order to overcome the barriers to physical activity in society at large. This report summarizes the outcome of the National Blueprint Consensus Conference that was held in October 2002. In this conference, representatives of more than 50 national organizations convened in Washington, D.C. with the goal of identifying high priority and high feasibility strategies which would advance the National Blueprint and which could be initiated within the next 12 to 24 months. Participants in the consensus conference were assigned to one of five breakout groups: home and community, marketing, medical systems, public policy, and research. Each breakout group was charged with identifying the three highest priority strategies within their area for effectively increasing physical activity levels in the mid-life and older adult population. In addition to the 15 strategies identified by the

  18. Antiviral Strategies Against Chikungunya Virus.

    Science.gov (United States)

    Abdelnabi, Rana; Neyts, Johan; Delang, Leen

    2016-01-01

    In the last few decades the Chikungunya virus (CHIKV) has evolved from a geographically isolated pathogen to a virus that is widespread in many parts of Africa, Asia and recently also in Central- and South-America. Although CHIKV infections are rarely fatal, the disease can evolve into a chronic stage, which is characterized by persisting polyarthralgia and joint stiffness. This chronic CHIKV infection can severely incapacitate patients for weeks up to several years after the initial infection. Despite the burden of CHIKV infections, no vaccine or antivirals are available yet. The current therapy is therefore only symptomatic and consists of the administration of analgesics, antipyretics, and anti-inflammatory agents. Recently several molecules with various viral or host targets have been identified as CHIKV inhibitors. In this chapter, we summarize the current status of the development of antiviral strategies against CHIKV infections. PMID:27233277

  19. Strategic Plan for Coordinating Rural Intelligent Transportation System (ITS) Transit Development in the Great Smoky Mountains National Park

    Energy Technology Data Exchange (ETDEWEB)

    Truett, L.F.

    2002-12-19

    The Great Smoky Mountains National Park, located along the border between North Carolina and Tennessee, is the most visited national park in the United States. This rugged, mountainous area presents many transportation challenges. The immense popularity of the Smokies and the fact that the primary mode of transportation within the park is the personal vehicle have resulted in congestion, damage to the environment, impacts on safety, and a degraded visitor experience. Access to some of the Smokies historical, cultural, and recreational attractions via a mass transit system could alleviate many of the transportation issues. Although quite a few organizations are proponents of a mass transit system for the Smokies, there is a lack of coordination among all parties. In addition, many local residents are not completely comfortable with the idea of transit in the Smokies. This document provides a brief overview of the current transportation needs and limitations in the Great Smoky Mountains National Park, identifies agencies and groups with particular interests in the Smokies, and offers insights into the benefits of using Intelligent Transportation Systems (ITS) technologies in the Smokies. Recommendations for the use of rural ITS transit to solve two major transportation issues are presented.

  20. Can antiviral drugs contain pandemic influenza transmission?

    Directory of Open Access Journals (Sweden)

    Niels G Becker

    Full Text Available Antiviral drugs dispensed during the 2009 influenza pandemic generally failed to contain transmission. This poses the question of whether preparedness for a future pandemic should include plans to use antiviral drugs to mitigate transmission.Simulations using a standard transmission model that allows for infected arrivals and delayed vaccination show that attempts to contain transmission require relatively few antiviral doses. In contrast, persistent use of antiviral drugs when the reproduction number remains above 1 use very many doses and are unlikely to reduce the eventual attack rate appreciably unless the stockpile is very large. A second model, in which the community has a household structure, shows that the effectiveness of a strategy of dispensing antiviral drugs to infected households decreases rapidly with time delays in dispensing the antivirals. Using characteristics of past pandemics it is estimated that at least 80% of primary household cases must present upon show of symptoms to have a chance of containing transmission by dispensing antiviral drugs to households. To determine data needs, household outbreaks were simulated with 50% receiving antiviral drugs early and 50% receiving antiviral drugs late. A test to compare the size of household outbreaks indicates that at least 100-200 household outbreaks need to be monitored to find evidence that antiviral drugs can mitigate transmission of the newly emerged virus.Use of antiviral drugs in an early attempt to contain transmission should be part of preparedness plans for a future influenza pandemic. Data on the incidence of the first 350 cases and the eventual attack rates of the first 200 hundred household outbreaks should be used to estimate the initial reproduction number R and the effectiveness of antiviral drugs to mitigate transmission. Use of antiviral drugs to mitigate general transmission should cease if these estimates indicate that containment of transmission is unlikely.

  1. Strategic Marketing

    OpenAIRE

    Potter, Ned

    2012-01-01

    This chapter from The Library Marketing Toolkit focuses on marketing strategy. Marketing is more successful when it happens as part of a constantly-renewing cycle. The aim of this chapter is to demystify the process of strategic marketing, simplifying it into seven key stages with advice on how to implement each one. Particular emphasis is put on dividing your audience and potential audience into segments, and marketing different messages to each group. It includes case studies from Terr...

  2. Benefits of a strategic national forest inventory to science and society: the USDA Forest Service Forest Inventory and Analysis program

    OpenAIRE

    Shaw JD

    2008-01-01

    Forest Inventory and Analysis, previously known as Forest Survey, is one of the oldest research and development programs in the USDA Forest Service. Statistically-based inventory efforts that started in Scandinavian countries in the 1920s raised interest in developing a similar program in the U.S. The U.S. Congress established the research branch of the U.S. Forest Service in 1928, shortly after Dr. Yrjo Ilvessalo, leader of the first Finnish national forest inventory, met with President Calv...

  3. Benefits of a strategic national forest inventory to science and society: the USDA Forest Service Forest Inventory and Analysis program

    Directory of Open Access Journals (Sweden)

    Shaw JD

    2008-02-01

    Full Text Available Forest Inventory and Analysis, previously known as Forest Survey, is one of the oldest research and development programs in the USDA Forest Service. Statistically-based inventory efforts that started in Scandinavian countries in the 1920s raised interest in developing a similar program in the U.S. The U.S. Congress established the research branch of the U.S. Forest Service in 1928, shortly after Dr. Yrjo Ilvessalo, leader of the first Finnish national forest inventory, met with President Calvin Coolidge. Congress charged the Forest Service to find "facts as may be necessary in the determination of ways and means to balance the timber budget of the United States". As a result, Forest Survey maintained a timber focus for much its history. As society's interest in forests changed over time, so did information needs. Conflicts over resource allocation and use could not be resolved without up-to-date knowledge of forest status and trends. In response to society's needs, the Forest Inventory and Analysis program has evolved from Forest Survey to address diverse topics such as forest health, carbon storage, wildlife habitat, air pollution, and invasive plants, while continuing its mandate to monitor the Nation's timber supply. The Forest Inventory and Analysis program collects data on all land ownerships on an annual basis. The data are used to develop reports on a regular basis; reports and raw data are available to the public at no cost. The data are also used by scientists in a growing number of applications. A short history of the Forest Survey is presented with several examples of current research based on Forest Inventory and Analysis data.

  4. 国家战略经济区风险和对策%Risks and Countermeasures of Economic Zones at the National Strategic Level

    Institute of Scientific and Technical Information of China (English)

    高建国

    2011-01-01

    近2年国家批准了20个国家发展战略经济区.在这些地区,随各自自然环境的变化其自然灾害风险有所不同.该文基于对国家战略发展区域的历史(1949-2009年)灾情调查统计,构建了以人均损失、地均损失、损失占GDP的比重及人均GDP、地均GDP等5个指标为主的自然灾害风险评价体系.研究结果表明:天津市滨海新区、上海浦东新区为低度风险区;深圳市综合配套改革试验区、珠江三角洲地区、长江三角洲地区、辽宁沿海经济带、江苏沿海地区、沈阳经济区、武汉城市圈、黄河三角洲高效生态经济区为中度风险区;关中-天水经济区、海峡西岸经济区、广西北部湾、中部地区、长吉图开发开放先导区、海南国际旅游岛综合试验区为较高度风险区;成渝统筹城乡发展综合配套改革试验区、甘肃省、长株潭城市群、鄱阳湖生态经济区为高度风险区.该文针对各区域自然灾害风险特点提出了发展对策.%Twenty economic zones at the national strategic level have been approved in the last two years. Risks of national disaster vary according to different natural circumstances of each economic zone. Based on the survey of the history of disaster situation of the economic zones at the national strategic level from 1949 to 2009, the paper constructes natural disaster risk assessment system involving five indicators,per capita loss, per unit area loss, proportion of the loss in the total. GDP, per capita GDP and per unit area GDP. The results show that Binhai New Zone of Tianjin City and Pudong New Zone of Shanghai City are the low risk zones, Experimental Zone of Shenzhen City, Pearl River Delta Region, Yangtze River Delta Region, Coastal Economic Belt of Liaoning Province,Coastal Area of Jiangsu Province, Economic Zone of Shenyang City, Wuhan City Circle and Highly Efficient Ecologicai Economy Zone of Yellow River Delta are the middle risk zones

  5. Advances and challenges in the implementation of strategic adaptive management beyond the Kruger National Park – Making linkages between science and biodiversity management

    Directory of Open Access Journals (Sweden)

    Angela Gaylard

    2011-05-01

    Full Text Available South African National Parks (SANParks makes use of strategic adaptive management (SAM to achieve its primary mandate of biodiversity conservation. This involves an iterative adaptive planning, management and review cycle to ensure appropriate alignment of stakeholder values with conservation objectives, to address the uncertainty inherent in complex social– economic–ecological systems and to learn explicitly whilst doing so. Adaptive management is recognised as the most logical framework for continuous improvement in natural resource management; nevertheless, several challenges in its implementation remain. This paper outlined these challenges and the various modifications to SANParks’ adaptive planning and management process that have emerged during its development. We demonstrated how the establishment of a regular Science–Management Forum provides opportunities for social colearning amongst resource managers and scientists of a particular park, whilst providing other positive spin-offs that mature the SAM process across the organisation. We discussed the use of particular conceptual constructs that clarify the link between monitoring, management requirements and operational endpoints, providing the context within which Thresholds of Potential Concern (TPCs should be set, prioritised and measured. The evolution of the TPC concept was also discussed in the context of its use by other organisations, whilst recognising its current limitations within SANParks. Finally, we discussed remaining implementation challenges and uncertainties, and suggested a way forward for SAM.Conservation implications: This paper outlined practical methods of implementing SAM in conservation areas, beyond what has already been learnt within, and documented for, the Kruger National Park. It also highlighted several implementation challenges that prove useful to other conservation agencies planning to adopt this approach to managing complex ecosystems.

  6. Impact and Cost of the HIV/AIDS National Strategic Plan for Mozambique, 2015-2019--Projections with the Spectrum/Goals Model.

    Directory of Open Access Journals (Sweden)

    Eline L Korenromp

    Full Text Available Mozambique continues to face a severe HIV epidemic and high cost for its control, largely born by international donors. We assessed feasible targets, likely impact and costs for the 2015-2019 national strategic HIV/AIDS plan (NSP.The HIV epidemic and response was modelled in the Spectrum/Goals/Resource Needs dynamical simulation model, separately for North/Center/South regions, fitted to antenatal clinic surveillance data, household and key risk group surveys, program statistics, and financial records. Intervention targets were defined in collaboration with the National AIDS Council, Ministry of Health, technical partners and implementing NGOs, considering existing commitments.Implementing the NSP to meet existing coverage targets would reduce annual new infections among all ages from 105,000 in 2014 to 78,000 in 2019, and reduce annual HIV/AIDS-related deaths from 80,000 to 56,000. Additional scale-up of prevention interventions targeting high-risk groups, with improved patient retention on ART, could further reduce burden to 65,000 new infections and 51,000 HIV-related deaths in 2019. Program cost would increase from US$ 273 million in 2014, to US$ 433 million in 2019 for 'Current targets', or US$ 495 million in 2019 for 'Accelerated scale-up'. The 'Accelerated scale-up' would lower cost per infection averted, due to an enhanced focus on behavioural prevention for high-risk groups. Cost and mortality impact are driven by ART, which accounts for 53% of resource needs in 2019. Infections averted are driven by scale-up of interventions targeting sex work (North, rising epidemic and voluntary male circumcision (Center & South, generalized epidemics.The NSP could aim to reduce annual new HIV infections and deaths by 2019 by 30% and 40%, respectively, from 2014 levels. Achieving incidence and mortality reductions corresponding to UNAIDS' 'Fast track' targets will require increased ART coverage and additional behavioural prevention targeting key risk

  7. Strategizing on innovation systems

    DEFF Research Database (Denmark)

    Jofre, Sergio

    This paper explores the strategic context of the implementation of the European Institute of Technology (EIT) from the perspective of National Innovation Systems (NIS) and the Triple Helix of University-Government-Industry relationship. The analytical framework is given by a comparative study of...... welfare creation – therefore, the NIS analysis inherently focuses on economy and emphasizes the role of industry over government and university. A complementary analytical concept that regards NIS from a slightly different perspective is the Triple Helix Model of innovation (e.g. Etzkowitz & Leydesdorff...... NIS in the EU and its closer competitors the US and Japan, with emphasis on the particular features and developments of their respective Triple Helix models. Based on the results of this analysis, the paper suggests strategic recommendations regarding the EIT deployment. The work aims an additional...

  8. Thinking strategically.

    Science.gov (United States)

    Goree, Michael

    2002-01-01

    Over the course of the past 20 years, human resources has tried a variety of strategic initiatives to add value to the working environment, from the alphabets of TQM, CQI, EVA, ROI, ISO, QS, Theory X, Y, Z, Generation X and Y to re-engineering, balanced scorecard, lean, hoshin, six sigma, to Margaret Wheatley's "The Simpler Way" and finally to cheese and fish. The problem is that none of these is a strategy. They are all tactics to accomplish or achieve a strategy.

  9. Strategic Management

    CERN Document Server

    Jeffs, Chris

    2008-01-01

    The Sage Course Companion on Strategic Management is an accessible introduction to the subject that avoids lengthy debate in order to focus on the core concepts. It will help the reader to develop their understanding of the key theories, whilst enabling them to bring diverse topics together in line with course requirements. The Sage Course Companion also provides advice on getting the most from your course work; help with analysing case studies and tips on how to prepare for examinations. Designed to compliment existing strategy textbooks, the Companion provides: -Quick and easy access to the

  10. Strategic Engagement

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    “Pakistan regards China as a strategic partner and the bilateral ties have endured the test of time.”Pakistani Prime Minister Shaukat Aziz made the comment during his four-day official visit to China on April 16 when he met Chinese President Hu Jintao,Premier Wen Jiabao and the NPC Standing Committee Chairman Wu Bangguo.His visit to China also included a trip to Boao,where he delivered a keynote speech at the Boao Forum for Asia held on April 20-22. During his stay in Beijing,the two countries signed 13 agreements on cooperation in the fields of space,telecommunications,education and legal assistance,which enhanced an already close strategic partnership. In an interview with Beijing Review reporter Pan Shuangqin,Prime Minister Aziz addressed a number of issues ranging from Asia’s searching for a win-win economic situation to the influence of Sino-Pakistani relations on regional peace.

  11. What You Should Know about Flu Antiviral Drugs

    Science.gov (United States)

    ... this? Submit What's this? Submit Button Past Newsletters What You Should Know About Flu Antiviral Drugs Language: ... that can be used to treat flu illness. What are antiviral drugs? Antiviral drugs are prescription medicines ( ...

  12. Antiviral effects of Glycyrrhiza species.

    Science.gov (United States)

    Fiore, Cristina; Eisenhut, Michael; Krausse, Rea; Ragazzi, Eugenio; Pellati, Donatella; Armanini, Decio; Bielenberg, Jens

    2008-02-01

    Historical sources for the use of Glycyrrhiza species include ancient manuscripts from China, India and Greece. They all mention its use for symptoms of viral respiratory tract infections and hepatitis. Randomized controlled trials confirmed that the Glycyrrhiza glabra derived compound glycyrrhizin and its derivatives reduced hepatocellular damage in chronic hepatitis B and C. In hepatitis C virus-induced cirrhosis the risk of hepatocellular carcinoma was reduced. Animal studies demonstrated a reduction of mortality and viral activity in herpes simplex virus encephalitis and influenza A virus pneumonia. In vitro studies revealed antiviral activity against HIV-1, SARS related coronavirus, respiratory syncytial virus, arboviruses, vaccinia virus and vesicular stomatitis virus. Mechanisms for antiviral activity of Glycyrrhiza spp. include reduced transport to the membrane and sialylation of hepatitis B virus surface antigen, reduction of membrane fluidity leading to inhibition of fusion of the viral membrane of HIV-1 with the cell, induction of interferon gamma in T-cells, inhibition of phosphorylating enzymes in vesicular stomatitis virus infection and reduction of viral latency. Future research needs to explore the potency of compounds derived from licorice in prevention and treatment of influenza A virus pneumonia and as an adjuvant treatment in patients infected with HIV resistant to antiretroviral drugs. PMID:17886224

  13. Antiviral targets of human noroviruses.

    Science.gov (United States)

    Prasad, Bv Venkataram; Shanker, Sreejesh; Muhaxhiri, Zana; Deng, Lisheng; Choi, Jae-Mun; Estes, Mary K; Song, Yongcheng; Palzkill, Timothy; Atmar, Robert L

    2016-06-01

    Human noroviruses are major causative agents of sporadic and epidemic gastroenteritis both in children and adults. Currently there are no licensed therapeutic intervention measures either in terms of vaccines or drugs available for these highly contagious human pathogens. Genetic and antigenic diversity of these viruses, rapid emergence of new strains, and their ability to infect a broad population by using polymorphic histo-blood group antigens for cell attachment, pose significant challenges for the development of effective antiviral agents. Despite these impediments, there is progress in the design and development of therapeutic agents. These include capsid-based candidate vaccines, and potential antivirals either in the form of glycomimetics or designer antibodies that block HBGA binding, as well as those that target essential non-structural proteins such as the viral protease and RNA-dependent RNA polymerase. In addition to these classical approaches, recent studies suggest the possibility of interferons and targeting host cell factors as viable approaches to counter norovirus infection. This review provides a brief overview of this progress. PMID:27318434

  14. Hepatitis C Virus and Antiviral Drug Resistance

    Science.gov (United States)

    Kim, Seungtaek; Han, Kwang-Hyub; Ahn, Sang Hoon

    2016-01-01

    Since its discovery in 1989, hepatitis C virus (HCV) has been intensively investigated to understand its biology and develop effective antiviral therapies. The efforts of the previous 25 years have resulted in a better understanding of the virus, and this was facilitated by the development of in vitro cell culture systems for HCV replication. Antiviral treatments and sustained virological responses have also improved from the early interferon monotherapy to the current all-oral regimens using direct-acting antivirals. However, antiviral resistance has become a critical issue in the treatment of chronic hepatitis C, similar to other chronic viral infections, and retreatment options following treatment failure have become important questions. Despite the clinical challenges in the management of chronic hepatitis C, substantial progress has been made in understanding HCV, which may facilitate the investigation of other closely related flaviviruses and lead to the development of antiviral agents against these human pathogens. PMID:27784846

  15. Strategic Planning: What's so Strategic about It?

    Science.gov (United States)

    Strong, Bart

    2005-01-01

    The words "strategic" and "planning" used together can lead to confusion unless one spent the early years of his career in never-ending, team-oriented, corporate training sessions. Doesn't "strategic" have something to do with extremely accurate bombing or a defensive missile system or Star Wars or something? Don't "strategic" and "planning" both…

  16. Antiviral active peptide from oyster

    Science.gov (United States)

    Zeng, Mingyong; Cui, Wenxuan; Zhao, Yuanhui; Liu, Zunying; Dong, Shiyuan; Guo, Yao

    2008-08-01

    An active peptide against herpes virus was isolated from the enzymic hydrolysate of oyster ( Crassostrea gigas) and purified with the definite direction hydrolysis technique in the order of alcalase and bromelin. The hydrolysate was fractioned into four ranges of molecular weight (>10 kDa, 10 5 kDa, 5 1 kDa and <1 kDa) using ultrafiltration membranes and dialysis. The fraction of 10 5 kDa was purified using consecutive chromatographic methods including DEAE Sephadex A-25 column, Sephadex G-25 column, and high performance liquid chromatogram (HPLC) by activity-guided isolation. The antiviral effect of the obtained peptide on herpetic virus was investigated in Vero cells by observing cytopathic effect (CPE). The result shows that the peptide has high inhibitory activity on herpetic virus.

  17. Antiviral active peptide from oyster

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    An active peptide against herpes virus was isolated from the enzymic hydrolysate of oyster (Crassostrea gigas) and purified with the definite direction hydrolysis technique in the order of alcalase and bromelin. The hydrolysate was fractioned into four ranges of molecular weight (>10 kDa, 10-5 kDa, 5-1 kDa and <1 kDa) using ultrafiltration membranes and dialysis. The fraction of 10?5 kDa was purified using consecutive chromatographic methods including DEAE Sephadex A-25 column, Sephadex G-25 column, and high performance liquid chromatogram (HPLC) by activity-guided isolation. The antiviral effect of the obtained peptide on herpetic virus was investigated in Vero cells by observing cytopathic effect (CPE). The result shows that the peptide has high inhibitory activity on herpetic virus.

  18. Antiviral Perspectives for Chikungunya Virus

    Directory of Open Access Journals (Sweden)

    Deepti Parashar

    2014-01-01

    Full Text Available Chikungunya virus (CHIKV is a mosquito-borne pathogen that has a major health impact in humans and causes acute febrile illness in humans accompanied by joint pains and, in many cases, persistent arthralgia lasting for weeks to years. CHIKV reemerged in 2005-2006 in several parts of the Indian Ocean islands and India after a gap of 32 years, causing millions of cases. The re-emergence of CHIKV has also resulted in numerous outbreaks in several countries in the eastern hemisphere, with a threat to further expand in the near future. However, there is no vaccine against CHIKV infection licensed for human use, and therapy for CHIKV infection is still mainly limited to supportive care as antiviral agents are yet in different stages of testing or development. In this review we explore the different perspectives for chikungunya treatment and the effectiveness of these treatment regimens and discuss the scope for future directions.

  19. Strategic Spatial Planning as Persuasive Storytelling

    DEFF Research Database (Denmark)

    Olesen, Kristian

    the persuasive power of spatial concepts in bringing transport infrastructure projects onto the national political agenda. In conclusion, the paper calls for critical attention to the rationalities underpinning practices of persuasive storytelling in contemporary strategic spatial planning....

  20. Antiviral Effect of Agaricomycetes Mushrooms (Review).

    Science.gov (United States)

    Teplyakova, Tamara V; Kosogova, Tatiana A

    2016-01-01

    This review presents data on the studied antiviral activities of Agaricomycetes mushrooms against the herpes, West Nile, influenza, human immunodeficiency, and hepatitis viruses, as well as orthopoxviruses, including the variola virus. Polysaccharides and other compounds (e.g., proteins, glycoproteins, terpenoids, melanins, nucleosides) exhibit antiviral activity against many viruses that are pathogenic in humans. Effective strains isolated from wild mushrooms in culture represent promising objects for the development of biotechnological drugs, including ones possessing antiviral activity. The data on antitumor and antiviral activities of compounds from the same mushroom species indicate the correlation of these properties. With regard to this connection, preparations of Basidiomycetes may have prophylactic value in preventing cancers with a viral etiology. PMID:27649599

  1. Managing for Results: Using Strategic Human Capital Management To Drive Transformational Change. Testimony before the National Commission on the Public Service.

    Science.gov (United States)

    Walker, David M.

    The General Accounting Office (GAO) examined the effectiveness of using strategic human capital (HC) management to drive transformational change in federal agencies and reported on its own implementation of a new competency-based performance management system. First, the potential impacts of the following three broad HC reform opportunities to…

  2. Strategic Collaboration

    Science.gov (United States)

    Umphrey, Jan

    2012-01-01

    This article presents a brief conversation with Denise Khaalid, the 2012 NASSP/Virco National Assistant Principal of the year. Khaalid shares the various responsibilities of being an assistant principal at South Pointe High School in Rock Hill, SC. She talks about her greatest accomplishments in her role as assistant principal for curriculum and…

  3. Evaluation of Antiviral Compounds Against Avian Influenza

    OpenAIRE

    Call, Evan W.

    1991-01-01

    Tests in vitro for antiviral activity against avian influenza viruses, A/Turkey/Sanpete/85 (H6N8) and A/Turkey/Sanpete/86 (H10N9), isolated in Sanpete County, Utah, utilized known antiviral agents, amantadine•HCl (adamantanamine hydrochloride) and ribavirin (1-β-D ribofuranosyl-1,2,4-triazole-3-carboxamide). The testing involved evaluation of seven drug concentrations. Maximum tolerated dose, minimum inhibitory concentration and therapeutic indexes were determined for each drug used. Both dru...

  4. Vaccines and Antiviral Drugs in Pandemic Preparedness

    OpenAIRE

    Arnold S. Monto

    2006-01-01

    While measures such as closing schools and social distancing may slow the effects of pandemic influenza, only vaccines and antiviral drugs are clearly efficacious in preventing infection or treating illness. Unless the pandemic strain closely resembles one already recognized, vaccine will not be available early. However, studies can be conducted beforehand to address questions concerning vaccine dose, frequency of inoculation, and need for adjuvants. In contrast, antiviral drugs, particularly...

  5. [Interferon : antiviral mechanisms and viral escape].

    Science.gov (United States)

    Espert, Lucile; Gongora, Céline; Mechti, Nadir

    2003-02-01

    15 % of human cancers have virus origin, meaning that viruses are the second cause of cancers after tabagism. The knowledge of antiviral mechanisms is essential for treatment and prevention of infection evolution towards cancers. Interferons (IFNs) are a large family of multifunctional cytokines. They are involved in regulation of cell growth and modulation of immune response. But, all these functions seem to converge toward the most important of them : the antiviral activity. IFN secretion is the first event induced by viral infection, and will act on specific receptors on neighbour cells and prevent their infection by inducing numbers of antiviral genes. Although few of them are well known like the PKR, the 2-5OAS/RNase L pathway and the Mx proteins, many others need extensive studies to understand the wide range of IFN effect. Viruses have evolved to circumvent the IFN antiviral activity, and are able not only to divert the cellular machinery but also to lure the antiviral mechanisms of the host cell. The purpose of this review is to describe the many antiviral pathways and proteins induced by IFNs and to summarize the strategies of viral escape. PMID:12660132

  6. Strategic management or strategic planning for defense?

    OpenAIRE

    Tritten, James John; Roberts, Nancy Charlotte

    1989-01-01

    Approved for public release; distribution is unlimited. This report describes problems associated with strategic planning and strategic management within DoD. Authors offer a series of suggested reforms to enhance mono-level planning and management within DoD, primarily by closer ties with industry planning groups, education, organizational structure, management information systems, and better integration. Additional sponsors are: OSD competitive Strategies Office, OSD Strategic Planning B...

  7. Strategizing NATOs Narratives

    DEFF Research Database (Denmark)

    Nissen, Thomas Elkjer

    2014-01-01

    , implementation structures, and capabilities can be used to inform the construction of strategic narratives in NATO. Using Libya as a case study he explains that the formulation and implementation of strategic narratives in NATO currently is a fragmented process that rarely takes into account the grand strategic......In chapter eleven , Thomas Elkjer Nissen argues that strategic narratives are a means for political actors to construct a shared meaning of international politics and to shape the perceptions, beliefs, and behavior of domestic and international actors. He demonstrates how time, position, legitimacy...... objectives formulated in NATO headquarters. Consequently, the future construction of strategic narratives in NATO must be based on the strategic variables....

  8. STRATEGIC AIRLIFT CAPABILITY: FROM THEORY TO PRACTICE

    Directory of Open Access Journals (Sweden)

    Cezar VASILESCU

    2011-01-01

    Full Text Available Strategic airlift remains a critical supporting capability that should be achieved, maintained and improved. This capability ensures the ability to deploy and sustain military forces across possible distant battlefields. The paper analyses the growing strategic airlift capabilities gap between operational needs and current realities, and underlines the need for an enhanced strategic airlift capability to meet current and future NATO alliance needs. By analyzing requirements against the existing/potential solutions, this paper further ponders over options like the organic national capability, partnerships such as the Strategic Airlift Consortium (SAC or leasing aircraft through a venture such as the Strategic Airlift Interim Solution (SALIS. The paper also evaluates the feasibility of applying these solutions to European Union airlift needs.

  9. Containing pandemic influenza with antiviral agents.

    Science.gov (United States)

    Longini, Ira M; Halloran, M Elizabeth; Nizam, Azhar; Yang, Yang

    2004-04-01

    For the first wave of pandemic influenza or a bioterrorist influenza attack, antiviral agents would be one of the few options to contain the epidemic in the United States until adequate supplies of vaccine were available. The authors use stochastic epidemic simulations to investigate the effectiveness of targeted antiviral prophylaxis to contain influenza. In this strategy, close contacts of suspected index influenza cases take antiviral agents prophylactically. The authors compare targeted antiviral prophylaxis with vaccination strategies. They model an influenza pandemic or bioterrorist attack for an agent similar to influenza A virus (H2N2) that caused the Asian influenza pandemic of 1957-1958. In the absence of intervention, the model predicts an influenza illness attack rate of 33% of the population (95% confidence interval (CI): 30, 37) and an influenza death rate of 0.58 deaths/1,000 persons (95% Cl: 0.4, 0.8). With the use of targeted antiviral prophylaxis, if 80% of the exposed persons maintained prophylaxis for up to 8 weeks, the epidemic would be contained, and the model predicts a reduction to an illness attack rate of 2% (95% Cl: 0.2, 16) and a death rate of 0.04 deaths/1,000 persons (95% CI: 0.0003, 0.25). Such antiviral prophylaxis is nearly as effective as vaccinating 80% of the population. Vaccinating 80% of the children aged less than 19 years is almost as effective as vaccinating 80% of the population. Targeted antiviral prophylaxis has potential as an effective measure for containing influenza until adequate quantities of vaccine are available.

  10. Revisiting Strategic versus Non-strategic Cooperation

    NARCIS (Netherlands)

    Reuben, E.; Suetens, S.

    2009-01-01

    We use a novel experimental design to disentangle strategically- and non-strategically-motivated cooperation. By using contingent responses in a repeated sequential prisoners’ dilemma with a known probabilistic end, we differentiate end-game behavior from continuation behavior within individuals whi

  11. An integrated service excellence model for strategic military test and evaluation facilities : the case of the South African National Department of Defence / Gerhard L. de Coning

    OpenAIRE

    De Coning, Gerhard Lourens

    2009-01-01

    Capital-intensive military test and evaluation facilities that are governed within the public entity domain need to deliver effective and efficient services in meeting or exceeding the Department of Defence's requirements and in retaining strategic defence capabilities and technologies. Various business and operational processes currently exist in these facilities, without any common quality assurance, control and performance management systems. The primary objective of this study was to deve...

  12. Strategic Risk Management

    OpenAIRE

    Sax, Johanna

    2015-01-01

    The aim of this thesis is to contribute to the literature with an investigation into strategic risk management practices from a strategic management and management accounting perspective. Previous research in strategic risk management has not provided sufficient evidence on the mechanisms behind firm practices, processes and tools for managing strategic risks, and their contingencies for value creation. In particular, the purpose of the thesis has been to fill the gaps in the l...

  13. Strategic information security

    CERN Document Server

    Wylder, John

    2003-01-01

    Introduction to Strategic Information SecurityWhat Does It Mean to Be Strategic? Information Security Defined The Security Professional's View of Information Security The Business View of Information SecurityChanges Affecting Business and Risk Management Strategic Security Strategic Security or Security Strategy?Monitoring and MeasurementMoving Forward ORGANIZATIONAL ISSUESThe Life Cycles of Security ManagersIntroductionThe Information Security Manager's Responsibilities The Evolution of Data Security to Information SecurityThe Repository Concept Changing Job Requirements Business Life Cycles

  14. Strategizing on innovation systems

    DEFF Research Database (Denmark)

    Jofre, Sergio

    and the supranational levels. Data is gathered from available literature. Conclusions and discussion The findings suggest that there are important disparities among NIS particularly at the level of systemic functions such as knowledge creation, knowledge diffusion, guidance, and human and financial resource......This paper explores the strategic context of the implementation of the European Institute of Technology (EIT) from the perspective of National Innovation Systems (NIS) and the Triple Helix of University-Government-Industry relationship. The analytical framework is given by a comparative study...... within the US innovation system such as the Massachusetts Institute of Technology (MIT), the EIT deployment does not considers the establishment of a physical institution such as MIT but a supranational network of pre-existing institutions. Whether this strategy will be able to bring the expected...

  15. Strategic Leadership Reconsidered

    Science.gov (United States)

    Davies, Brent; Davies, Barbara J.

    2005-01-01

    This paper will address the challenge of how strategic leadership can be defined and articulated to provide a framework for developing a strategically focused school drawing on a NCSL research project. The paper is structured into three main parts. Part one outlines the elements that comprise a strategically focused school, develops an…

  16. Antivirals Use During the Pandemic H1N1 2009 Outbreak

    Centers for Disease Control (CDC) Podcasts

    2012-01-23

    Charisma Atkins, CDC public health analyst, discusses antiviral use during the 2009 H1N1 pandemic flu outbreak.  Created: 1/23/2012 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 1/23/2012.

  17. 77 FR 35410 - Fogarty International Center 2013 Strategic Plan

    Science.gov (United States)

    2012-06-13

    ... input from scientists, the general public, and interested parties. The goal of this strategic planning... HUMAN SERVICES National Institutes of Health Fogarty International Center 2013 Strategic Plan SUMMARY: The Fogarty International Center (FIC), National Institutes of Health (NIH) is updating its...

  18. Strategic Workshops on Cancer Nanotechnology

    OpenAIRE

    Nagahara, Larry A.; Lee, Jerry S.H.; Molnar, Linda K.; Panaro, Nicholas J.; Farrell, Dorothy; Ptak, Krzysztof; Alper, Joseph; Grodzinski, Piotr

    2010-01-01

    Nanotechnology offers the potential for new approaches to detecting, treating and preventing cancer. To determine the current status of the cancer nanotechnology field and the optimal path forward, the National Cancer Institute’s Alliance for Nanotechnology in Cancer held three strategic workshops, covering the areas of in-vitro diagnostics and prevention, therapy and post-treatment, and in-vivo diagnosis and imaging. At each of these meetings, a wide range of experts from academia, industry,...

  19. A fresh look at an antiviral helicase

    Institute of Scientific and Technical Information of China (English)

    Leonid Gitlin; Marco Colonna

    2007-01-01

    @@ In order to survive,all organlsms must guard against viral infections.Recognition of viruses is accomplished via multiple sensors.Many mammalian proteins can recognize viral products,such as double-stranded RNA(dsRNA),yet feW of them are known to induce interferon,the central antiviral messenger.Since interferon is indispensable for Successful antiviral defense [1],the interferon-inducing sensors have been of particular interest.However,a clear understanding of such sensors has been elusive,and the first well-established sensor family,the toll-like receptors (TLRs),was described relatively recently[2].Antiviral TLRS are positioned in the endosomes,where they report the appearance of viral genetic material(DNA,single-and double-stranded RNA).

  20. Antiviral activity of constituents of Tamus communis.

    Science.gov (United States)

    Aquino, R; Conti, C; De Simone, F; Orsi, N; Pizza, C; Stein, M L

    1991-10-01

    The antiviral activity of the phenanthrene derivatives 1-6, of the spyrostane triglycosides dioscin (7) and gracillin (8), of the furostanol tetraglycosides methylprotodioscin (9), its (25S) epimer methylprotoneodioscin (10), and methylprotogracillin 11, have been tested towards two RNA viruses: vesicular stomatitis virus and human rhinovirus type 1B. All these products were extracted from the rizomes of Tamus communis L; compound 11 was isolated also from Asparagus cochinchinesis, together with pseudoprotodioscin (12), a 20 (22)-unsaturated furostanoside, which was also investigated for antiviral activity. The results were of some interest mainly for the phenanthrene derivatives. PMID:1667189

  1. Strategic Analysis Overview

    Science.gov (United States)

    Cirillo, William M.; Earle, Kevin D.; Goodliff, Kandyce E.; Reeves, J. D.; Stromgren, Chel; Andraschko, Mark R.; Merrill, R. Gabe

    2008-01-01

    NASA s Constellation Program employs a strategic analysis methodology in providing an integrated analysis capability of Lunar exploration scenarios and to support strategic decision-making regarding those scenarios. The strategic analysis methodology integrates the assessment of the major contributors to strategic objective satisfaction performance, affordability, and risk and captures the linkages and feedbacks between all three components. Strategic analysis supports strategic decision making by senior management through comparable analysis of alternative strategies, provision of a consistent set of high level value metrics, and the enabling of cost-benefit analysis. The tools developed to implement the strategic analysis methodology are not element design and sizing tools. Rather, these models evaluate strategic performance using predefined elements, imported into a library from expert-driven design/sizing tools or expert analysis. Specific components of the strategic analysis tool set include scenario definition, requirements generation, mission manifesting, scenario lifecycle costing, crew time analysis, objective satisfaction benefit, risk analysis, and probabilistic evaluation. Results from all components of strategic analysis are evaluated a set of pre-defined figures of merit (FOMs). These FOMs capture the high-level strategic characteristics of all scenarios and facilitate direct comparison of options. The strategic analysis methodology that is described in this paper has previously been applied to the Space Shuttle and International Space Station Programs and is now being used to support the development of the baseline Constellation Program lunar architecture. This paper will present an overview of the strategic analysis methodology and will present sample results from the application of the strategic analysis methodology to the Constellation Program lunar architecture.

  2. Antiviral Prophylaxis and Isolation for the Control of Pandemic Influenza

    OpenAIRE

    Qingxia Zhang; Dingcheng Wang

    2014-01-01

    Before effective vaccines become available, antiviral drugs are considered as the major control strategies for a pandemic influenza. However, perhaps such control strategies can be severely hindered by the low-efficacy of antiviral drugs. For this reason, using antiviral drugs and an isolation strategy is included in our study. A compartmental model that allows for imported exposed individuals and asymptomatic cases is used to evaluate the effectiveness of control strategies via antiviral pro...

  3. 75 FR 9232 - Office of Dietary Supplements (ODS) 2010-2014 Strategic Plan

    Science.gov (United States)

    2010-03-01

    ... HUMAN SERVICES National Institutes of Health Office of Dietary Supplements (ODS) 2010-2014 Strategic Plan ACTION: Notice of availability of the ODS Strategic Plan for 2010-2014. SUMMARY: The Office of Dietary Supplements (ODS) at the National Institutes of Health (NIH) has completed a strategic...

  4. DMPD: Antiviral innate immunity pathways. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16474426 Antiviral innate immunity pathways. Seth RB, Sun L, Chen ZJ. Cell Res. 200...6 Feb;16(2):141-7. (.png) (.svg) (.html) (.csml) Show Antiviral innate immunity pathways. PubmedID 16474426 ...Title Antiviral innate immunity pathways. Authors Seth RB, Sun L, Chen ZJ. Publication Cell Res. 2006 Feb;16

  5. The IKK Kinases: Operators of Antiviral Signaling

    Directory of Open Access Journals (Sweden)

    Alissa M. Pham

    2010-01-01

    Full Text Available The ability of a cell to combat an intracellular pathogen requires a mechanism to recognize the threat and elicit a transcriptional response against it. In the context of virus infection, the cell must take measures to inhibit viral replication, meanwhile, convey warning signals to neighboring cells of the imminent threat. This immune response is predominantly mediated by the production of cytokines, notably, interferon beta (IFNβ. IFNβ signaling results in the transcriptional induction of over one hundred antiviral gene products whose timely expression renders infected cells more capable of inhibiting virus replication, while providing the uninfected cells with the reinforcements to generate a less permissive cellular environment. Induction of IFNβ and many aspects of the antiviral response pivot on the function of the IKK and IKK-related kinases. Despite sharing high levels of homology and some degree of functional redundancy, the classic IKK kinases: IKKα and IKKβ, and the IKK-related kinases: TBK1 and IKKε, perform distinct roles in regulating the host antiviral defense. These kinases serve as molecular operators in their cooperative ability to integrate incoming cellular cues and act on a range of essential antiviral transcription factors to reshape the cellular transcriptome during infection.

  6. Antiviral drug resistance of herpes simplex virus

    NARCIS (Netherlands)

    Stranska, Ruzena

    2004-01-01

    Infections with herpes simplex virus (HSV) usually have an asymptomatic or benign course. However, severe infections do occur, particularly in HIV/AIDS patients or transplant recipients, and may be life-threatening unless adequate antiviral therapy is given. Since its introduction in the early 1980

  7. Antiviral Medications for Treatment of 2009 H1N1 Influenza and Pregnancy

    Centers for Disease Control (CDC) Podcasts

    2009-11-09

    This podcast features CDC's Dr. Sonja Rasmussen discussing the latest guidelines related to antiviral medications for treatment of 2009 H1N1 Influenza. Excerpt from a CDC-Medscape video series for physicians, nurses, pharmacists, and other healthcare professionals.  Created: 11/9/2009 by National Center for Health Marketing (NCHM); National Center on Birth Defects and Developmental Disabilities (NCBDDD).   Date Released: 1/21/2010.

  8. Antiviral effect of cationic compounds on bacteriophages

    Directory of Open Access Journals (Sweden)

    Mai Huong eChatain-Ly

    2013-03-01

    Full Text Available The antiviral activity of several cationic compounds - cetytrimethylammonium (CTAB, chitosan, nisin and lysozyme - was investigated on the bacteriophage c2 (DNA head and non-contractile tail infecting Lactococcus strains and the bacteriophage MS2 (F-specific RNA infecting E.coli. Firstly, these activities were evaluated in a phosphate buffer pH 7- 10 mM. The CTAB had a virucidal effect on the Lactococcus bacteriophages, but not on the MS2. After 1 min of contact with 0.125 mM CTAB, the c2 population was reduced from 6 log(pfu/mL to 1,5 log(pfu/mL and completely deactivated at 1 mM. On the contrary, chitosan inhibited the MS2 more than it did the bacteriophages c2. No antiviral effect was observed for the nisin or the lysozyme on bacteriophages after 1 min of treatment. A 1 and 2.5 log reduction was respectively observed for nisin and lysozyme when the treatment time increased (5 or 10 min. These results showed that the antiviral effect depended both on the virus and structure of the antimicrobial compounds. The antiviral activity of these compounds was also evaluated in different physico-chemical conditions and in complex matrices. The antiviral activity of CTAB was impaired in acid pH and with an increase of the ionic strength. These results might be explained by the electrostatic interactions between cationic compounds and negatively charged particles such as bacteriophages or other compounds in a matrix. Milk proved to be protective suggesting the components of food could interfere with antimicrobial compounds.

  9. Strategic Thoughts in Organizations

    Directory of Open Access Journals (Sweden)

    Juliane Inês Di Francesco Kich

    2014-08-01

    Full Text Available This paper aims to analyze a new way of thinking about the organizational strategies through a theoretical discussion of the term "strategic thoughts", and its development in organizations. To achieve this, a bibliographical research was conducted in order to go more deeply on the theme and reach a conceptual background, which can support further analysis. Among the results of this research, it is emphasized that the pragmatic characteristics of strategic planningappears to not have more space in the current organizational world, this tool needs to be interconnected to the strategic thought process to bring more effective results. In this regard, the challenged is present in how the organizations could develop a strategic planning that encourages strategic thoughts instead of undermine it, as well as, the development of tools that promote the ability to think strategically in all employees, regardless of the hierarchical levels.

  10. Complex Strategic Choices

    DEFF Research Database (Denmark)

    Leleur, Steen

    . Complex Strategic Choices provides clear principles and methods which can guide and support strategic decision making to face the many current challenges. By considering ways in which planning practices can be renewed and exploring the possibilities for acquiring awareness and tools to add value...... and students in the field of planning and decision analysis as well as practitioners dealing with strategic analysis and decision making. More broadly, Complex Strategic Choices acts as guide for professionals and students involved in complex planning tasks across several fields such as business...... to strategic decision making, Complex Strategic Choices presents a methodology which is further illustrated by a number of case studies and example applications. Dr. Techn. Steen Leleur has adapted previously established research based on feedback and input from various conferences, journals and students...

  11. Arms Control and Strategic Stability

    Institute of Scientific and Technical Information of China (English)

    Hu; Yumin

    2014-01-01

    This essay intends to offer a comment on concepts, trends and attitudes concerning arms control and strategic stability with reference to the current international security situation. It also offers observations from two different perspectives about strategic stability: one proceeds from the concept of universal security and aims to prevent conflicts and instability from disrupting regional and international security environment on which nation states depend so much for their peaceful development; the other starts from maintaining the global leadership by a super power and aiming to contain any challenge that sways or is likely to sway its dominating status. If China and the United States commit themselves to the undertaking of a new type of major powers relationship that stresses win-win cooperation, they will be able to contribute greatly to a stable international security architecture that is good for world peaceful development.

  12. Strategic Belief Management

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul

    While (managerial) beliefs are central to many aspects of strategic organization, interactive beliefs are almost entirely neglected, save for some game theory treatments. In an increasingly connected and networked economy, firms confront coordination problems that arise because of network effects....... The capability to manage beliefs will increasingly be a strategic one, a key source of wealth creation, and a key research area for strategic organization scholars....

  13. Cultivating strategic thinking skills.

    Science.gov (United States)

    Shirey, Maria R

    2012-06-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change initiatives. With the goal of presenting practical approaches helpful to nurse leaders advancing organizational change, content includes evidence-based projects, tools, and resources that mobilize and sustain organizational change initiatives. In this article, the author presents an overview of strategic leadership and offers approaches for cultivating strategic thinking skills.

  14. Strategic Marketing Planning Audit

    OpenAIRE

    Violeta Radulescu

    2012-01-01

    Market-oriented strategic planning is the process of defining and maintaining a viable relationship between objectives, training of personnel and resources of an organization, on the one hand and market conditions, on the other hand. Strategic marketing planning is an integral part of the strategic planning process of the organization. For successful marketing organization to obtain a competitive advantage, but also to measure the effectiveness of marketing actions the company is required to ...

  15. Strategic thinking in business

    OpenAIRE

    Špatenková, Lenka

    2011-01-01

    Strategic thinking in a bussines – summary This diploma work deals with the issue of strategic thinking in business, which is an inseparable part of the development of company strategy. The utilisation of the principles of strategies thinking as well as the processes and analyses of strategic management is shown on the example of REBYTO BEAR Ltd. The Theoretical Background Chapter provides explanation of important terminology whose knowledge is necessary for the practical use of strate...

  16. Telepreneurship : Strategic bliss

    OpenAIRE

    Erasmus, Izak Pierre

    2010-01-01

    The strategic management literature indirectly considers entrepreneurship as a subset of strategy, and the historical evolution of the field, specifically that of the Entrepreneurship division of the Academy of Management. Schendel (1990) which placed great emphasis on the topic of entrepreneurship and admitted that some argue that entrepreneurship is at the very heart of strategic management. This thesis explores the strategic use of entrepreneurship in the telecommunication industry. Throug...

  17. Strategic Management: General Concepts

    OpenAIRE

    Shahram Tofighi

    2010-01-01

    In the era after substitution of long term planning by strategic planning, it was wished that the managers could act more successful in implementing their plans. The outcomes were far from the expected, there were minor improvements. In the organizations, a plenty of namely strategic plans has been developed during strategic planning processes, but most of these plans have been kept in the shelves, a few of them played their roles as guiding documents for the entire organization. What are the...

  18. Sandia Strategic Plan 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-01

    Sandia embarked on its first exercise in corporate strategic planning during the winter of 1989. The results of that effort were disseminated with the publication of Strategic Plan 1990. Four years later Sandia conducted their second major planning effort and published Strategic Plan 1994. Sandia`s 1994 planning effort linked very clearly to the Department of Energy`s first strategic plan, Fueling a Competitive Economy. It benefited as well from the leadership of Lockheed Martin Corporation, the management and operating contractor. Lockheed Martin`s corporate success is founded on visionary strategic planning and annual operational planning driven by customer requirements and technology opportunities. In 1996 Sandia conducted another major planning effort that resulted in the development of eight long-term Strategic Objectives. Strategic Plan 1997 differs from its predecessors in that the robust elements of previous efforts have been integrated into one comprehensive body. The changes implemented so far have helped establish a living strategic plan with a stronger business focus and with clear deployment throughout Sandia. The concept of a personal line of sight for all employees to this strategic plan and its objectives, goals, and annual milestones is becoming a reality.

  19. Strategic planning for neuroradiologists.

    Science.gov (United States)

    Berlin, Jonathan W; Lexa, Frank J

    2012-08-01

    Strategic planning is becoming essential to neuroradiology as the health care environment continues to emphasize cost efficiency, teamwork and collaboration. A strategic plan begins with a mission statement and vision of where the neuroradiology division would like to be in the near future. Formalized strategic planning frameworks, such as the strengths, weaknesses, opportunities and threats (SWOT), and the Balanced Scorecard frameworks, can help neuroradiology divisions determine their current position in the marketplace. Communication, delegation, and accountability in neuroradiology is essential in executing an effective strategic plan. PMID:22902108

  20. DCOI Strategic Plan

    Data.gov (United States)

    General Services Administration — Under the Data Center Optimization Initiative (DCOI), covered agencies are required to post DCOI Strategic Plans and updates to their FITARA milestones publicly on...

  1. Strategic planning for neuroradiologists.

    Science.gov (United States)

    Berlin, Jonathan W; Lexa, Frank J

    2012-08-01

    Strategic planning is becoming essential to neuroradiology as the health care environment continues to emphasize cost efficiency, teamwork and collaboration. A strategic plan begins with a mission statement and vision of where the neuroradiology division would like to be in the near future. Formalized strategic planning frameworks, such as the strengths, weaknesses, opportunities and threats (SWOT), and the Balanced Scorecard frameworks, can help neuroradiology divisions determine their current position in the marketplace. Communication, delegation, and accountability in neuroradiology is essential in executing an effective strategic plan.

  2. How Strategic are Strategic Information Systems?

    Directory of Open Access Journals (Sweden)

    Alan Eardley

    1996-11-01

    Full Text Available There are many examples of information systems which are claimed to have created and sustained competitive advantage, allowed beneficial collaboration or simply ensured the continued survival of the organisations which used them These systems are often referred to as being 'strategic'. This paper argues that many of the examples of strategic information systems as reported in the literature are not sufficiently critical in determining whether the systems meet the generally accepted definition of the term 'strategic' - that of achieving sustainable competitive advantage. Eight of the information systems considered to be strategic are examined here from the standpoint of one widely-accepted 'competition' framework- Porter's model of industry competition . The framework is then used to question the linkage between the information systems and the mechanisms which are required for the enactment of strategic business objectives based on competition. Conclusions indicate that the systems are compatible with Porter's framework. Finally, some limitations of the framework are discussed and aspects of the systems which extend beyond the framework are highlighted

  3. An Understanding of The Maritime Silk Road International Strategic Importance

    Institute of Scientific and Technical Information of China (English)

    Lin; Hongyu

    2015-01-01

    "The Maritime Silk Road"conception has a very significant international strategic importance,and to China,will certainly play a great role in promoting its economic development,which is only on the surface,and an in-depth reading is that it is a top-level strategic design,whose strategic role with the passage of time will be enlarged.In his address to Indonesian National Assembly in October 2013,President Xi

  4. The Relationship between Firms’ Strategic Orientations and Strategic Planning Process

    OpenAIRE

    Hasnanywati Hassan

    2010-01-01

    The study examines the quantity surveying (QS) firms’ strategic orientation and its relation to strategic planningprocess. The strategic orientations based on Miles and Snow typology were used to identify the strategicorientation for QS firms. The strategic planning process that includes the efforts of strategic planning, degree ofinvolvement in strategic planning and formality were also determined. The declined period in Malaysianconstruction industry from year 2001 to 2005 has been determin...

  5. THE SOUTH AFRICAN MILITARY IN TRANSITION: PART 2 – FROM STRATEGIC CULTURE TO STRATEGIC REALITY

    OpenAIRE

    Gerhard M Louw; Abel Esterhuyse

    2014-01-01

    The analysis reported here focused on the dynamic interaction between a preferred strategic management model of the South African National Defence Force (SANDF) on the one hand, and the SANDF’s acquired strategic culture on the other. From a theoretical perspective, the analysis draws attention to the fact that the properties of institutional culture inform the extent to which an organisation (such as the SANDF) suffers the deleterious consequences of an inappropriate management model. The ar...

  6. Developing Strategic Leaders.

    Science.gov (United States)

    Carter, Patricia; Terwilliger, Leatha; Alfred, Richard L.; Hartleb, David; Simone, Beverly

    2002-01-01

    Highlights the importance of developing community college leaders capable of demonstrating strategic leadership and responding to the global forces that influence community college education. Discusses the Consortium for Community College Development's Strategic Leadership Forum and its principles, format, content, and early results. (RC)

  7. Strategic Risk Assessment

    Science.gov (United States)

    Derleth, Jason; Lobia, Marcus

    2009-01-01

    This slide presentation provides an overview of the attempt to develop and demonstrate a methodology for the comparative assessment of risks across the entire portfolio of NASA projects and assets. It includes information about strategic risk identification, normalizing strategic risks, calculation of relative risk score, and implementation options.

  8. Strategic Leadership in Schools

    Science.gov (United States)

    Williams, Henry S.; Johnson, Teryl L.

    2013-01-01

    Strategic leadership is built upon traits and actions that encompass the successful execution of all leadership styles. In a world that is rapidly changing, strategic leadership in schools guides school leader through assuring constant improvement process by anticipating future trends and planning for them and noting that plans must be flexible to…

  9. Manage "Human Capital" Strategically

    Science.gov (United States)

    Odden, Allan

    2011-01-01

    To strategically manage human capital in education means restructuring the entire human resource system so that schools not only recruit and retain smart and capable individuals, but also manage them in ways that support the strategic directions of the organization. These management practices must be aligned with a district's education improvement…

  10. Strategic HRD within companies

    NARCIS (Netherlands)

    Wognum, A.A.M.; Mulder, M.M.

    1999-01-01

    This article reports a preliminary survey that was conducted within the framework of the project on strategic human resource development (HRD), in which for various aspects of organisations the effects of strategic HRD are explored. The aim of the survey was to explore some conditions that are impor

  11. 11. Strategic planning.

    Science.gov (United States)

    2014-05-01

    There are several types of planning processes and plans, including strategic, operational, tactical, and contingency. For this document, operational planning includes tactical planning. This chapter examines the strategic planning process and includes an introduction into disaster response plans. "A strategic plan is an outline of steps designed with the goals of the entire organisation as a whole in mind, rather than with the goals of specific divisions or departments". Strategic planning includes all measures taken to provide a broad picture of what must be achieved and in which order, including how to organise a system capable of achieving the overall goals. Strategic planning often is done pre-event, based on previous experience and expertise. The strategic planning for disasters converts needs into a strategic plan of action. Strategic plans detail the goals that must be achieved. The process of converting needs into plans has been deconstructed into its components and includes consideration of: (1) disaster response plans; (2) interventions underway or planned; (3) available resources; (4) current status vs. pre-event status; (5) history and experience of the planners; and (6) access to the affected population. These factors are tempered by the local: (a) geography; (b) climate; (c) culture; (d) safety; and (e) practicality. The planning process consumes resources (costs). All plans must be adapted to the actual conditions--things never happen exactly as planned.

  12. Exploiting Genetic Interference for Antiviral Therapy.

    Science.gov (United States)

    Tanner, Elizabeth J; Kirkegaard, Karla A; Weinberger, Leor S

    2016-05-01

    Rapidly evolving viruses are a major threat to human health. Such viruses are often highly pathogenic (e.g., influenza virus, HIV, Ebola virus) and routinely circumvent therapeutic intervention through mutational escape. Error-prone genome replication generates heterogeneous viral populations that rapidly adapt to new selection pressures, leading to resistance that emerges with treatment. However, population heterogeneity bears a cost: when multiple viral variants replicate within a cell, they can potentially interfere with each other, lowering viral fitness. This genetic interference can be exploited for antiviral strategies, either by taking advantage of a virus's inherent genetic diversity or through generating de novo interference by engineering a competing genome. Here, we discuss two such antiviral strategies, dominant drug targeting and therapeutic interfering particles. Both strategies harness the power of genetic interference to surmount two particularly vexing obstacles-the evolution of drug resistance and targeting therapy to high-risk populations-both of which impede treatment in resource-poor settings.

  13. An antiviral furanoquinone from Paulownia tomentosa Steud.

    Science.gov (United States)

    Kang, K H; Huh, H; Kim, B K; Lee, C K

    1999-11-01

    A methanol extract of the stem bark of Paulownia tomentosa showed antiviral activity against poliovirus types 1 and 3. Sequential liquid-liquid extraction with n-hexane, chloroform and water, and a silicagel column chromatography resulted in the purification of a compound. The compound was identified as methyl-5-hydroxy-dinaphthol[1,2-2',3']furan-7,12-dione-6-carbox yla te on the basis of spectroscopic data. The component caused a significant reduction of viral cytopathic effect when it was subjected to a standard antiviral assay by using HeLa cells. The EC(50) of the compound against poliovirus type 1 strain Brunhilde, and type 3 strain Leon were 0.3 microg/mL and 0.6 microg/mL, respectively. PMID:10548761

  14. Strategic planning in transition

    DEFF Research Database (Denmark)

    Olesen, Kristian; Richardson, Tim

    2012-01-01

    In this paper, we analyse how contested transitions in planning rationalities and spatial logics have shaped the processes and outputs of recent episodes of Danish ‘strategic spatial planning’. The practice of ‘strategic spatial planning’ in Denmark has undergone a concerted reorientation...... style of ‘strategic spatial planning’ with its associated spatial logics is continuously challenged by a persistent regulatory, top-down rationality of ‘strategic spatial planning’, rooted in spatial Keynesianism, which has long characterised the Danish approach. The findings reveal the emergence...... of a particularly Danish approach, retaining strong regulatory aspects. However this approach does not sit easily within the current neoliberal political climate, raising concerns of an emerging crisis of ‘strategic spatial planning’....

  15. Antiviral and Immunostimulant Activities of Andrographis paniculata

    OpenAIRE

    Churiyah; Olivia Bunga Pongtuluran; Elrade Rofaani; Tarwadi,

    2015-01-01

    Andrographis paniculata (Burm. f.) Nees is a medicinal plant which was reported to have anti HIV, anti pathogenic bacteria and immunoregulatory activities. The research purpose was to investigate the activity of Andrographis paniculata ethanol extract as antiviral and immunostimulant. A. paniculata leaves oven-dried, then grinded and macerated with ethanol 90%, and the extract then analyzed using High Performance Liquid Chromatography (HPLC) to determine the content of active compounds androg...

  16. Antiviral Strategies for Pandemic and Seasonal Influenza

    OpenAIRE

    Fang Fang; Maria Hedlund; Larson, Jeffrey L.

    2010-01-01

    While vaccines are the primary public health response to seasonal and pandemic flu, short of a universal vaccine there are inherent limitations to this approach. Antiviral drugs provide valuable alternative options for treatment and prophylaxis of influenza. Here, we will review drugs and drug candidates against influenza with an emphasis on the recent progress of a host-targeting entry-blocker drug candidate, DAS181, a sialidase fusion protein.

  17. The treatment of influenza with antiviral drugs

    OpenAIRE

    Stiver, Grant

    2003-01-01

    Influenza vaccination with current inactivated vaccines homologous to the prevalent wild-type virus can reduce influenza illness in 75%–80% of healthy adults. Vaccine is recommended for all individuals with chronic underlying diseases and for those aged 65 years or older. Although influenza vaccination is still advocated for patients with blunted immunity, protection rates are not as high, running at 40% for frail institutionalized elderly people. The influenza antiviral agents amantadine or ...

  18. ANTIVIRAL POTENTIAL OF MEDICINAL PLANTS: AN OVERVIEW

    OpenAIRE

    Ruwali Pushpa; Rai Nishant; Kumar Navin; Gautam Pankaj

    2013-01-01

    The term ‘Antiviral agents’ has been defined in very broad terms as substances other than a virus or virus containing vaccine or specific antibody which can produce either a protective or therapeutic effect to the clear detectable advantage of the virus infected host. The herbal medicine has a long traditional use and the major advantage over other medicines is their wide therapeutic window with rare side effects. There are some disadvantages of synthetic drugs like narrow therapeutic window...

  19. Antiviral Drug Resistance: Mechanisms and Clinical Implications

    OpenAIRE

    Strasfeld, Lynne; Chou, Sunwen

    2010-01-01

    Antiviral drug resistance is an increasing concern in immunocompromised patient populations, where ongoing viral replication and prolonged drug exposure lead to the selection of resistant strains. Rapid diagnosis of resistance can be made by associating characteristic viral mutations with resistance to various drugs as determined by phenotypic assays. Management of drug resistance includes optimization of host factors and drug delivery, selection of alternative therapies based on knowledge of...

  20. Antiviral lead compounds from marine sponges

    KAUST Repository

    Sagar, Sunil

    2010-10-11

    Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme clusters in sponges and/or their associated symbiotic microorganisms. Natural product lead compounds from sponges have often been found to be promising pharmaceutical agents. Several of them have successfully been approved as antiviral agents for clinical use or have been advanced to the late stages of clinical trials. Most of these drugs are used for the treatment of human immunodeficiency virus (HIV) and herpes simplex virus (HSV). The most important antiviral lead of marine origin reported thus far is nucleoside Ara-A (vidarabine) isolated from sponge Tethya crypta. It inhibits viral DNA polymerase and DNA synthesis of herpes, vaccinica and varicella zoster viruses. However due to the discovery of new types of viruses and emergence of drug resistant strains, it is necessary to develop new antiviral lead compounds continuously. Several sponge derived antiviral lead compounds which are hopedto be developed as future drugs are discussed in this review. Supply problems are usually the major bottleneck to the development of these compounds as drugs during clinical trials. However advances in the field of metagenomics and high throughput microbial cultivation has raised the possibility that these techniques could lead to the cost-effective large scale production of such compounds. Perspectives on biotechnological methods with respect to marine drug development are also discussed. 2010 by the authors; licensee MDPI.

  1. Strategic regulation of gas transport

    International Nuclear Information System (INIS)

    -exporting cartel it may be more profitable for such a cartel to coordinate their availability pricing policy than their export volumes. Another result shows that increased competition in the import market may be a disadvantage for the exporting countries when the authorities use strategic availability pricing. Consequently the use of strategic availability pricing could contribute to increase the conflict levels between the exporting and importing countries as to competition policy. If all the participants use strategic availability pricing the conflict of interests between the upstream and downstream countries would be complete as the importing country would wish to stimulate increased competition in all parts of the value chain while the exporting countries would wish the opposite. The analysis is based on a theoretical model and is consequently based on several conditions that must be considered when interpreting the results. The authors think however, that the mechanisms revealed are central in the market for natural gas. As long as the national authorities permit a certain degree of flexibility in the regulation of the availability prices for the transport and distribution of natural gas the strategic availability pricing could be an important measure in the battle for as large a part of the profits as possible in a future market for natural gas characterized by increased competition. As to Norway this would mean that possible negative effects of a more liberalised European gas market could be counteracted through strategic adaptation of the availability price in the Norwegian gas transport system

  2. Reflections on strategic nurse leadership.

    Science.gov (United States)

    White, Jean

    2012-10-01

    This paper sets out some personal reflections by the Chief Nursing Officer for Wales on the challenges facing nurses and midwives as they undertake strategic leadership roles in NHS organisations. The paper looks at the national approach taken in Wales where behavioural competencies for executive nurse directors have been implemented. It considers the implications of the breadth of responsibilities executive nurse directors have and the importance of developing and supporting middle grade nurse managers and clinical directors. It concludes by looking at who is responsible for care within an organisation. PMID:23050616

  3. Reflections on strategic nurse leadership.

    Science.gov (United States)

    White, Jean

    2012-10-01

    This paper sets out some personal reflections by the Chief Nursing Officer for Wales on the challenges facing nurses and midwives as they undertake strategic leadership roles in NHS organisations. The paper looks at the national approach taken in Wales where behavioural competencies for executive nurse directors have been implemented. It considers the implications of the breadth of responsibilities executive nurse directors have and the importance of developing and supporting middle grade nurse managers and clinical directors. It concludes by looking at who is responsible for care within an organisation.

  4. The strategic issues - structural elements of strategic management

    OpenAIRE

    Balta Corneliu

    2013-01-01

    The paper presents the most important concepts related to strategic management and the connection with strategic results as they are obtained after the main steps in strategic management are followed. The dynamics of the relationship between strategic issues and objectives is included

  5. Idaho National Laboratory/Nuclear Power Industry Strategic Plan for Light Water Reactor Research and Development An Industry-Government Partnership to Address Climate Change and Energy Security

    Energy Technology Data Exchange (ETDEWEB)

    Electric Power Research

    2007-11-01

    The dual issues of energy security and climate change mitigation are driving a renewed debate over how to best provide safe, secure, reliable and environmentally responsible electricity to our nation. The combination of growing energy demand and aging electricity generation infrastructure suggests major new capacity additions will be required in the years ahead.

  6. Strategic Alliances: the Potential for Russian Nanoindustry

    Directory of Open Access Journals (Sweden)

    Inshakova Elena Ivanovna

    2015-05-01

    Full Text Available Strategic alliances as a form of interfirm cooperation (including international cooperation increase the potential of solving large-scale problems of national nanoindustry development, providing synergy of participants resources united by the principle of complementarity and substitution in the process of joint implementation of complex R&D programs, mobilization and input of significant financial, material, technical and intellectual resources of the participants in nanotechnology projects. Strategic alliances in nanoindustry with national and international companies participation are defined as institutional and organizational form of interfirm cooperation. At this, the upper limit of its functioning is represented by hierarchical relations in transactions within the integrated structures, and the low limit by heterarchical relations in transactions among the detached firms. The paper identifies the main factors of successful functioning of strategic alliances in nanoindustry. At the same time, the participants pursuit of their own economic interests (including non-matching interests will inevitably become a source of origin and accumulation of contradictions in the alliance, which can cause its disintegration or acquisition of a weaker, passive participant by a stronger one. This determines the need for a thorough study of decisions on entering into a strategic alliance, on tactical and operational participation in its management in accordance with the contribution of partners to its creation, defining their authority and share in the results of operations. The article also studies the experience of strategic alliances formation in American and European nanoindustry, and exemplifies the potential of such interfirm cooperation in the realia of Russian economy.

  7. Strategic Communication Institutionalized

    DEFF Research Database (Denmark)

    Kjeldsen, Anna Karina

    2013-01-01

    of institutionalization when strategic communication is not yet visible as organizational practice, and how can such detections provide explanation for the later outcome of the process? (2) How can studies of strategic communication benefit from an institutional perspective? How can the virus metaphor generate a deeper...... understanding of the mechanisms that interact from the time an organization is exposed to a new organizational idea such as strategic communication until it surfaces in the form of symptoms such as mission and vision statements, communication manuals and communication positions? The first part of the article...... communication in three Danish art museums....

  8. HIV/HCV Antiviral Drug Interactions in the Era of Direct-acting Antivirals

    Science.gov (United States)

    Rice, Donald P.; Faragon, John J.; Banks, Sarah; Chirch, Lisa M.

    2016-01-01

    Abstract Therapy for human immunodeficiency virus (HIV) and chronic hepatitis C has evolved over the past decade, resulting in better control of infection and clinical outcomes; however, drug-drug interactions remain a significant hazard. Joint recommendations from the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America regarding drug-drug interactions between HIV antiretroviral agents and direct-acting antiviral agents for treatment of hepatitis C virus (HCV) infection are reviewed here. This review is oriented to facilitate appropriate selection of an antiviral therapy regimen for HCV infection based on the choice of antiretroviral therapy being administered and, if necessary, switching antiretroviral regimens. PMID:27777891

  9. Small molecules with antiviral activity against the Ebola virus

    OpenAIRE

    Nadia Litterman; Christopher Lipinski; Sean Ekins

    2015-01-01

    The recent outbreak of the Ebola virus in West Africa has highlighted the clear shortage of broad-spectrum antiviral drugs for emerging viruses. There are numerous FDA approved drugs and other small molecules described in the literature that could be further evaluated for their potential as antiviral compounds. These molecules are in addition to the few new antivirals that have been tested in Ebola patients but were not originally developed against the Ebola virus, and may play an important r...

  10. Determining Mechanism of Action of Antivirals for Respiratory Illness

    Science.gov (United States)

    Rodriguez, Irma; Dobrovolny, Hana

    2015-03-01

    Viral infections in the respiratory tract are common in humans and can cause serious illness and death. Drug treatment is the principal line of protection against many of these illnesses and many compounds are tested as antivirals. Often the efficacy of these antivirals are determined before a mechanism of action is understood. We use mathematical models to represent the evolution of these diseases and establish which experiments can help determine the mechanism of action of antivirals.

  11. 76 FR 64327 - Office of Oceanic and Atmospheric Research Draft Strategic Plan

    Science.gov (United States)

    2011-10-18

    ... strategic direction for program and laboratory planning. DATES: Public comments are due by 5 p.m., EST... Strategic Plan AGENCY: Office of Oceanic and Atmospheric Research (OAR), National Oceanic and Atmospheric... public comment. SUMMARY: This notice announces that OAR's draft Strategic Plan (FY12- 18) is...

  12. The Strategic Study of National Quality Award through Business Excellence Model - The IBM, Panasonic and E.SUN Bank Cases in Taiwan

    Directory of Open Access Journals (Sweden)

    Shih-Lung Fu

    2009-10-01

    Full Text Available Quality is a dignity to a country and also masterpiece and bedrock for the development of a country. To recover economical prosperity immediately right from the II world war, Japan founded Demin Quality Award to encourage the improvement of quality and promote the whole scale of competence core for enterprises in 1951. All the products produced by Japan are entirely favoured by the customers around the world during the period of 1975. The Japanese made automobiles, electronics and appliances are inexpensive and competitive enough to sluggish the economy growth of USA. To counter the serious threats and regain the advantage of the market, the United States finally founded Malcolm Baldrige National Quality Award, MBNQA to provide a series of standards for excellence performance in 1987. European Excellence Award was set up by the European Foundation for Quality Management, EFQM for advancing the superiority of tech development in 1991. Among the developing countries, there is no exception can be made for the emerging countries, especially in area of Aisa. Taiwan is the first country in Asia to establish Taiwan National Quality Award, TNQA in 1990 to represent the great honour of quality, also the first national quality award in this area. As the candidate with the great potential to be developed country in this region, not only Taiwan is struggling to advance its technology, but also promote the quality issues by quality related policies of government. Therefore, this paper is to examine the process of involvement in the promotion to Taiwan National Quality Award for three different enterprises, the 1assessment of various dimension in company through spot visit by judges of TNQA, and the analysis of interview record from the superior executives for the further research and introductive contribution of this award. Conclusively, this paper is trying to draw the overview of how to improve the excellence of quality in the practice of business

  13. Strategic Management: General Concepts

    Directory of Open Access Journals (Sweden)

    Shahram Tofighi

    2010-05-01

    Full Text Available In the era after substitution of long term planning by strategic planning, it was wished that the managers could act more successful in implementing their plans. The outcomes were far from the expected, there were minor improvements. In the organizations, a plenty of namely strategic plans has been developed during strategic planning processes, but most of these plans have been kept in the shelves, a few of them played their roles as guiding documents for the entire organization. What are the factors inducing such outcomes? Different scientists have offered a variety of justifications, according to their expe-riences."nThe first examined issue was misunderstanding stra-tegic planning by the managers and staff; it means the strategic planning process may be executed erroneously, and what they had expected from this process was not accurate. Substantially, strategic planning looks at the future and coming situations, and is designed to answer the questions which emerge in the future. Unfortunately, this critical and fundamental characteristic of strategic planning is obscured."nStrategic planning conveys the concept of drawing the future and developing a set of different probable scenarios along with defining a set of solutions in order to combat undesirable coming conditions for positioning the system or business. It helps organizations save themselves safe and maintain them successful. In other words, in strategic planning efforts we are seeking solutions fit for problems which will appear in the future for the conditions that will emerge in the future. Unfortunately, most of strategic plans which have been developed in the organizations lack this important and critical characteristic; I mean in most of them the developers had offered solutions in order to solve today's problems in the future! "nThe second issue which was considered by the scientists, was the task of ensuring the continuity of effectiveness of the planning, there was a

  14. Complex Strategic Choices

    DEFF Research Database (Denmark)

    Leleur, Steen

    . Complex Strategic Choices provides clear principles and methods which can guide and support strategic decision making to face the many current challenges. By considering ways in which planning practices can be renewed and exploring the possibilities for acquiring awareness and tools to add value...... resulting in new material stemming from and focusing on practical application of a systemic approach. The outcome is a coherent and flexible approach named systemic planning. The inclusion of both the theoretical and practical aspects of systemic planning makes this book a key resource for researchers...... and students in the field of planning and decision analysis as well as practitioners dealing with strategic analysis and decision making. More broadly, Complex Strategic Choices acts as guide for professionals and students involved in complex planning tasks across several fields such as business...

  15. Strategic agility for nursing leadership.

    Science.gov (United States)

    Shirey, Maria R

    2015-06-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change. In this article, the author discusses strategic agility as an important leadership competency and offers approaches for incorporating strategic agility in healthcare systems. A strategic agility checklist and infrastructure-building approach are presented.

  16. 2003 U.S. Department of Energy Strategic Plan: Protecting National, Energy, and Economic Security with Advanced Science and Technology and Ensuring Environmental Cleanup

    Energy Technology Data Exchange (ETDEWEB)

    None,

    2003-09-30

    The Department of Energy contributes to the future of the Nation by ensuring energy security, maintaining the safety, security and reliability of the nuclear weapons stockpile, cleaning up the environment from the legacy of the Cold War, and developing innovations in science and technology. After 25 years in existence, the Department now operates 24 preeminent research laboratories and facilities and four power marketing administrations, and manages the environmental cleanup from 50 years of nuclear defense activities that impacted two million acres in communities across the country. The Department has an annual budget of about $23 billion and employs about 14,500 Federal and 100,000 contractor employees. The Department of Energy is principally a national security agency and all of its missions flow from this core mission to support national security. That is true not just today, but throughout the history of the agency. The origins of the Department can be traced to the Manhattan Project and the race to develop the atomic bomb during World War II. Following the war, Congress engaged in a vigorous and contentious debate over civilian versus military control of the atom. The Atomic Energy Act of 1946 settled the debate by creating the Atomic Energy Commission, which took over the Manhattan Project’s sprawling scientific and industrial complex.

  17. 2016 Federal Cybersecurity Research and Development Strategic Plan

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — As part of the Presidents Cybersecurity National Action Plan (CNAP), the Administration released the 2016 Federal Cybersecurity Research and Development Strategic...

  18. Comparison of the NCRA and NAACCR Strategic Management Plans.

    Science.gov (United States)

    Menck, Herman R

    2012-01-01

    The Strategic Management Plans of the National Cancer Registrars Association (NCRA) and the North American Association of Central Cancer Registries (NAACCR) were compared, and differences noted. No uncovered subject areas were found.

  19. Systems biology: A tool for charting the antiviral landscape.

    Science.gov (United States)

    Bowen, James R; Ferris, Martin T; Suthar, Mehul S

    2016-06-15

    The host antiviral programs that are initiated following viral infection form a dynamic and complex web of responses that we have collectively termed as "the antiviral landscape". Conventional approaches to studying antiviral responses have primarily used reductionist systems to assess the function of a single or a limited subset of molecules. Systems biology is a holistic approach that considers the entire system as a whole, rather than individual components or molecules. Systems biology based approaches facilitate an unbiased and comprehensive analysis of the antiviral landscape, while allowing for the discovery of emergent properties that are missed by conventional approaches. The antiviral landscape can be viewed as a hierarchy of complexity, beginning at the whole organism level and progressing downward to isolated tissues, populations of cells, and single cells. In this review, we will discuss how systems biology has been applied to better understand the antiviral landscape at each of these layers. At the organismal level, the Collaborative Cross is an invaluable genetic resource for assessing how genetic diversity influences the antiviral response. Whole tissue and isolated bulk cell transcriptomics serves as a critical tool for the comprehensive analysis of antiviral responses at both the tissue and cellular levels of complexity. Finally, new techniques in single cell analysis are emerging tools that will revolutionize our understanding of how individual cells within a bulk infected cell population contribute to the overall antiviral landscape.

  20. Antiviral therapy of decompensated hepatitis B virus-related cirrhosis

    Institute of Scientific and Technical Information of China (English)

    CHEN Guang-cheng; YU Tao; HUANG Kai-hong; CHEN Qi-kui

    2012-01-01

    Objective To review the development,mechanism,necessity and limitation of antiviral therapy in decompensated hepatitis B virus-related cirrhosis.Data sources Most information was pulled from a literature search (Pubmed 2000 to 2011) using the keywords of antiviral and decompensated hepatitis B virus-related cirrhosis.Relevant book chapters were also reviewed.Study selection Well-controlled,prospective landmark studies and review articles on antiviral therapy in decompesated hepatitis B virus-related cirrhosis were selected.Results Specific antiviral agents not only control viral replication,which permits liver transplantation,but also improve liver function so significantly that patients could be removed from the transplant waiting list.However,the emergence of drug-resistant mutants can result in treatment failure.Combination therapy is a save-strategy in drug-resistant.Conclusions Although the treatment of end-stage liver disease is still a challenge worldwide,antiviral therapy has altered the natural history of hepatitis B patients with decompensated cirrhosis.The approval of the new generation of antivirals is opening new perspectives for finding the optimal antiviral treatment for patients with decompensated cirrhosis and preventing antiviral resistance.A combination of antivirals may be one of the future strategies for fulfilling these goals.

  1. Strategizing in multiple ways

    DEFF Research Database (Denmark)

    Larsen, Mette Vinther; Madsen, Charlotte Øland; Rasmussen, Jørgen Gulddahl

    2013-01-01

    Strategy processes are kinds of wayfaring where different actors interpret a formally defined strat-egy differently. In the everyday practice of organizations strategizing takes place in multiple ways through narratives and sensible actions. This forms a meshwork of polyphonic ways to enact one a...... based on this development paper is whether one can understand these diver-gent strategic wayfaring processes as constructive for organizations....

  2. 2015 Enterprise Strategic Vision

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-08-01

    This document aligns with the Department of Energy Strategic Plan for 2014-2018 and provides a framework for integrating our missions and direction for pursuing DOE’s strategic goals. The vision is a guide to advancing world-class science and engineering, supporting our people, modernizing our infrastructure, and developing a management culture that operates a safe and secure enterprise in an efficient manner.

  3. FY16-20 Strategic Plan.

    Energy Technology Data Exchange (ETDEWEB)

    Harwell, Amber Suzanne [Sandia National Lab. (SNL-CA), Livermore, CA (United States)

    2015-07-01

    Welcome to our FY16–FY20 Strategic Plan, which both refects our continued dedication to the work we do and reinforces the importance of the integrated Laboratories’ strategic framework to our future. This document is the result of the leadership team’s journey over the past few years in response to the needs of our nation. In an external environment that continues to change, sometimes in unexpected ways, it is critical that our mission areas and our foundation become increasingly synergistic, forming a whole whose parts are interdependent.

  4. 近代民族企业逆袭外企策略分析%Strategic Analysis of How Modern National Enterprises Counterattacked Foreign Companies

    Institute of Scientific and Technical Information of China (English)

    卢晶

    2014-01-01

    在近代中外企业的竞争格局中,民族企业并非总是软弱挨欺,民族企业成功逆袭外企的案例屡见不鲜。其成功逆袭外企的策略如下:更优质的产品,更低廉的价格;更刻苦的自主创新精神、更领先国外的科技;更丰厚的回报和让利;更具综合优势的经营模式;更智慧灵活的营销策略;更前瞻的融资手段;更具竞争力的团队精神;更顺民意、更具雄心的强国、爱国精神……这些策略,对当今的民营企业不无启迪。%In the modern competitive situations of domestic and foreign enterprises, national enterprises were not always on the weak side. It was often seen that some national enterprises successfully counterattacked their foreign opponents. The strategies of their successf ul counterattacks mainly included the f ollowing points, namely, more high quality products, lower prices, more assiduous spirit of independent innovation, more advanced science and technology, more generous returns and beneifts, more comprehensively advanced management modes, more intelligent and lfexible marketing strategies, more forward-looking ifnancings, more competitive team spirits, more ambitious patriotic spirits with more suitable public opinions. The strategies provide inspiration for today’s national enterprises.

  5. Strategic analysis of the company

    OpenAIRE

    Matoušková, Irena

    2012-01-01

    Strategic analysis of the company In my thesis I developed a strategic analysis of the company Pacovské strojírny a.s. I describe the various methods of internal and external strategic analysis in the theoretical part. I followed the methods used in the practical part. In an internal strategic analysis, I focused on the identification of internal resources and capabilities, the financial analysis and the chain of creating value. External strategic analysis includes PEST analysis, Porter's fiv...

  6. Nation branding and sustainable competitiveness of nations

    NARCIS (Netherlands)

    Lee, Kyung Mi

    2009-01-01

    Considering the importance of explaining how a nation brand is effectively managed and how nation branding aligns the nation's brand with country management so as to gain competitiveness, this research aims to assess the role of nation branding and to create a strategic management tool for nation br

  7. Guidelines for strategic planning

    Energy Technology Data Exchange (ETDEWEB)

    1991-07-01

    Strategic planning needs to be done as one of the integral steps in fulfilling our overall Departmental mission. The role of strategic planning is to assure that the longer term destinations, goals, and objectives which the programs and activities of the Department are striving towards are the best we can envision today so that our courses can then be set to move in those directions. Strategic planning will assist the Secretary, Deputy Secretary, and Under Secretary in setting the long-term directions and policies for the Department and in making final decisions on near-term priorities and resource allocations. It will assist program developers and implementors by providing the necessary guidance for multi-year program plans and budgets. It is one of the essential steps in the secretary's Strategic Planning Initiative. The operational planning most of us are so familiar with deals with how to get things done and with the resources needed (people, money, facilities, time) to carry out tasks. Operating plans like budgets, capital line item projects, R D budgets, project proposals, etc., are vital to the mission of the Department. They deal, however, with how to carry out programs to achieve some objective or budget assumption. Strategic planning deals with the prior question of what it is that should be attempted. It deals with what objectives the many programs and activities of the Department of Department should be striving toward. The purpose of this document is to provide guidance to those organizations and personnel starting the process for the first time as well as those who have prepared strategic plans in the past and now wish to review and update them. This guideline should not be constructed as a rigid, restrictive or confining rulebook. Each organization is encouraged to develop such enhancements as they think may be useful in their planning. The steps outlined in this document represent a very simplified approach to strategic planning. 9 refs.

  8. Strategic forces briefing

    Energy Technology Data Exchange (ETDEWEB)

    Bing, G.; Chrzanowski, P.; May, M.; Nordyke, M.

    1989-04-06

    The Strategic Forces Briefing'' is our attempt, accomplished over the past several months, to outline and highlight the more significant strategic force issues that must be addressed in the near future. Some issues are recurrent: the need for an effective modernized Triad and a constant concern for force survivability. Some issues derive from arms control: the Strategic Arms Reduction Talks (SALT) are sufficiently advanced to set broad numerical limits on forces, but not so constraining as to preclude choices among weapon systems and deployment modes. Finally, a new administration faced with serious budgetary problems must strive for the most effective strategic forces limited dollars can buy and support. A review of strategic forces logically begins with consideration of the missions the forces are charged with. We begin the briefing with a short review of targeting policy and implementation within the constraints of available unclassified information. We then review each element of the Triad with sections on SLBMs, ICBMs, and Air-Breathing (bomber and cruise missile) systems. A short section at the end deals with the potential impact of strategic defense on offensive force planning. We consider ABM, ASAT, and air defense; but we do not attempt to address the technical issues of strategic defense per se. The final section gives a brief overview of the tritium supply problem. We conclude with a summary of recommendations that emerge from our review. The results of calculation on the effectiveness of various weapon systems as a function of cost that are presented in the briefing are by Paul Chrzanowski.

  9. Neuropsychiatric Effects of HIV Antiviral Medications.

    Science.gov (United States)

    Treisman, Glenn J; Soudry, Olivia

    2016-10-01

    The development of antiretroviral therapy (ART) has dramatically increased the lifespan of HIV patients but treatment is complicated by numerous adverse effects and toxicities. ART complications include neuropsychiatric, metabolic, gastrointestinal, cardiac, and numerous other toxicities, and clinicians often have to choose one toxicity over another to offer the best medication regimen for a patient. Some antiviral drugs cause significant neuropsychiatric complications, including depression, cognitive impairment, and sleep disturbance. Even in careful studies, it may be difficult to determine which effects are related to the virus, the immune system, or the treatment. Of the six currently marketed classes of antiviral drugs, the nucleoside reverse transcriptase inhibitors and the non-nucleoside reverse transcriptase inhibitors have been most commonly associated with neuropsychiatric complications. Within these classes, certain drugs are more likely to cause difficulty than others. We review the contention regarding the central nervous system (CNS) complications of efavirenz, as well as debate about the role of CNS penetration in drug effectiveness and toxicity. A thorough working knowledge of the neuropsychiatric consequences of ART allows clinicians to tailor treatment more successfully to individual patients as well as to identify ART more quickly as the source of a problem or symptom. PMID:27534750

  10. Antiviral and Immunostimulant Activities of Andrographis paniculata

    Directory of Open Access Journals (Sweden)

    Churiyah

    2015-04-01

    Full Text Available Andrographis paniculata (Burm. f. Nees is a medicinal plant which was reported to have anti HIV, anti pathogenic bacteria and immunoregulatory activities. The research purpose was to investigate the activity of Andrographis paniculata ethanol extract as antiviral and immunostimulant. A. paniculata leaves oven-dried, then grinded and macerated with ethanol 90%, and the extract then analyzed using High Performance Liquid Chromatography (HPLC to determine the content of active compounds andrographolide. The antiviral activity of the extract was determined by observing its ability on inhibiting virus load in A549 cells transfected with Simian Retro Virus (SRV by Real Time – Polymerase Chain Reaction (RT-PCR analysis. The immunostimulant activity of extract was determined by its ability to induce lymphocytes cell proliferation using 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT assay. Our result indicated that the A. paniculata ethanol extract inhibited the SRV virus titer similar to the positive control Lamivudine, and it was not toxic to the A459 cell line. Furthermore, low concentration (1 μg/mL of A. paniculata extract could stimulated lymphocyte cell proliferation about 38% compared to the control lymphocyte cell without any treatment.

  11. Exploiting Genetic Interference for Antiviral Therapy.

    Science.gov (United States)

    Tanner, Elizabeth J; Kirkegaard, Karla A; Weinberger, Leor S

    2016-05-01

    Rapidly evolving viruses are a major threat to human health. Such viruses are often highly pathogenic (e.g., influenza virus, HIV, Ebola virus) and routinely circumvent therapeutic intervention through mutational escape. Error-prone genome replication generates heterogeneous viral populations that rapidly adapt to new selection pressures, leading to resistance that emerges with treatment. However, population heterogeneity bears a cost: when multiple viral variants replicate within a cell, they can potentially interfere with each other, lowering viral fitness. This genetic interference can be exploited for antiviral strategies, either by taking advantage of a virus's inherent genetic diversity or through generating de novo interference by engineering a competing genome. Here, we discuss two such antiviral strategies, dominant drug targeting and therapeutic interfering particles. Both strategies harness the power of genetic interference to surmount two particularly vexing obstacles-the evolution of drug resistance and targeting therapy to high-risk populations-both of which impede treatment in resource-poor settings. PMID:27149616

  12. 美国生物防御对策研究与国家战略储备药物分析%U.S. bioterrorism countermeasures and strategic national stockpile

    Institute of Scientific and Technical Information of China (English)

    仇玮祎; 余云舟; 孙志伟; 黄培堂; 郑涛

    2012-01-01

    To address the increasingly severe bio-terrorism threats, the United States government issued a series of regulations and research plans. In this article, we discussed American national biological defense strategies and their derivative plans based on the core of Project BioShield, including Department of Health and Human Service ( DHHS)/Biomedical Advanced R&D Authority(BARDA) biological terrorist response plan and budget plan, the Centers for Disease Control and Prevention (CDC) pathogens based top priority chemical, biological, rediological and nuclear (CBRN) threat countermeasures scheme and other important pathogenic organisms defense plans. Atter that, we also discussed the trend of research and development of the Strategical National Stockpile.%美国政府为应对日趋严峻的生物恐怖威胁,出台了一系列针对生化袭击的法规和研究计划.本文研究了以生物盾牌计划为核心的美国国家生物防御应对策略及其衍生计划,包括卫生与公众服务部( DHHS)/生物医学高级研究发展局(BARDA)生物恐怖应对计划及预算方案、以疾控中心(CDC)病原体清单为基础的顶级核化生威胁对策方案及其他重要病原体生物防御治疗研究计划等.分析了目前以上述研究为依托纳入国家战略储备体系的药物及研发趋势.

  13. Antiviral Treatment among Pregnant Women with Chronic Hepatitis B

    Directory of Open Access Journals (Sweden)

    Lin Fan

    2014-01-01

    Full Text Available Objective. To describe the antiviral treatment patterns for chronic hepatitis B (CHB among pregnant and nonpregnant women. Methods. Using 2011 MarketScan claims, we calculated the rates of antiviral treatment among women (aged 10–50 years with CHB. We described the pattern of antiviral treatment during pregnancy and ≥1 month after delivery. Results. We identified 6274 women with CHB during 2011. Among these, 64 of 507 (12.6% pregnant women and 1151 of 5767 (20.0% nonpregnant women received antiviral treatment (P < 0.01. Pregnant women were most commonly prescribed tenofovir (73.4% and lamivudine (21.9%; nonpregnant women were most commonly prescribed tenofovir (50.2% and entecavir (41.3% (P < 0.01. Among 48 treated pregnant women with an identifiable delivery date, 16 (33.3% were prescribed an antiviral before pregnancy and continued treatment for at least one month after delivery; 14 (29.2% started treatment during the third trimester and continued at least one month after delivery. Conclusion. Among this insured population, pregnant women with CHB received an antiviral significantly less often than nonpregnant women. The most common antiviral prescribed for pregnant women was tenofovir. These data provide a baseline for assessing changes in treatment patterns with anticipated increased use of antivirals to prevent breakthrough perinatal hepatitis B virus infection.

  14. Antiviral Treatment among Pregnant Women with Chronic Hepatitis B

    Science.gov (United States)

    Fan, Lin; Owusu-Edusei, Kwame; Schillie, Sarah F.; Murphy, Trudy V.

    2014-01-01

    Objective. To describe the antiviral treatment patterns for chronic hepatitis B (CHB) among pregnant and nonpregnant women. Methods. Using 2011 MarketScan claims, we calculated the rates of antiviral treatment among women (aged 10–50 years) with CHB. We described the pattern of antiviral treatment during pregnancy and ≥1 month after delivery. Results. We identified 6274 women with CHB during 2011. Among these, 64 of 507 (12.6%) pregnant women and 1151 of 5767 (20.0%) nonpregnant women received antiviral treatment (P < 0.01). Pregnant women were most commonly prescribed tenofovir (73.4%) and lamivudine (21.9%); nonpregnant women were most commonly prescribed tenofovir (50.2%) and entecavir (41.3%) (P < 0.01). Among 48 treated pregnant women with an identifiable delivery date, 16 (33.3%) were prescribed an antiviral before pregnancy and continued treatment for at least one month after delivery; 14 (29.2%) started treatment during the third trimester and continued at least one month after delivery. Conclusion. Among this insured population, pregnant women with CHB received an antiviral significantly less often than nonpregnant women. The most common antiviral prescribed for pregnant women was tenofovir. These data provide a baseline for assessing changes in treatment patterns with anticipated increased use of antivirals to prevent breakthrough perinatal hepatitis B virus infection. PMID:25548510

  15. Beyond RNAi: antiviral defense strategies in Drosophila and mosquito

    NARCIS (Netherlands)

    Merkling, S.H.; Rij, R.P. van

    2013-01-01

    Virus transmission and spread by arthropods is a major economic and public health concern. The ongoing dissemination of arthropod-borne viruses by blood-feeding insects is an important incentive to study antiviral immunity in these animals. RNA interference is a major mechanism for antiviral defense

  16. Induction and suppression of the innate antiviral responses by picornaviruses

    NARCIS (Netherlands)

    Feng, Q.

    2014-01-01

    On the front line of innate antiviral immune reactions is the type I interferon (IFN-α/β) system. IFN-α/β are small signaling molecules that can be produced by virtually all nucleated cells in our body upon virus infections, and induce a so-called “antiviral state” in neighboring cells by activating

  17. An innate antiviral pathway acting before interferons at epithelial surfaces

    DEFF Research Database (Denmark)

    Iversen, Marie B; Reinert, Line S; Thomsen, Martin K;

    2015-01-01

    we identify an innate antiviral pathway that works at epithelial surfaces before the IFNs. The pathway is activated independently of known innate sensors of viral infections through a mechanism dependent on viral O-linked glycans, which induce CXCR3 chemokines and stimulate antiviral activity in a...

  18. Antiviral activity of luteolin against Japanese encephalitis virus.

    Science.gov (United States)

    Fan, Wenchun; Qian, Suhong; Qian, Ping; Li, Xiangmin

    2016-07-15

    Japanese encephalitis virus (JEV), a member of family Flaviviridae, is a neurotropic flavivirus that causes Japanese encephalitis (JE). JEV is one of the most important causative agents of viral encephalitis in humans, and this disease leads to high fatality rates. Although effective vaccines are available, no effective antiviral therapy for JE has been developed. Hence, identifying effective antiviral agents against JEV infection is important. In this study, we found that luteolin was an antiviral bioflavonoid with potent antiviral activity against JEV replication in A549 cells with IC50=4.56μg/mL. Luteolin also showed extracellular virucidal activity on JEV. With a time-of-drug addition assay revealing that JEV replication was inhibited by luteolin after the entry stage. Overall, our results suggested that luteolin can be used to develop an antiviral drug against JEV. PMID:27126774

  19. Innate Antiviral Defenses Independent of Inducible IFNα/β Production.

    Science.gov (United States)

    Paludan, Søren R

    2016-09-01

    The type I interferons (IFNs) (IFNα and IFNβ) not only have potent antiviral activities, but also have pathological functions if produced at high levels or over a long time. Recent articles have described antiviral immune mechanisms that are activated in response to virus infection at epithelial surfaces independently of IFNα and IFNβ. This may allow the host to exert rapid local antiviral activity and only induce a full-blown, and potentially pathological, type I IFN response in situations where stronger protective immunity is needed. Here, I describe the emerging understanding of early antiviral defenses, which are independent of type I IFN responses, and also discuss how this enables tissues to exert rapid antiviral activities and to limit type I IFN production. PMID:27345728

  20. Strategic self-ignorance

    DEFF Research Database (Denmark)

    Thunström, Linda; Nordström, Leif Jonas; Shogren, Jason F.;

    2016-01-01

    We examine strategic self-ignorance—the use of ignorance as an excuse to over-indulge in pleasurable activities that may be harmful to one’s future self. Our model shows that guilt aversion provides a behavioral rationale for present-biased agents to avoid information about negative future impacts...... of such activities. We then confront our model with data from an experiment using prepared, restaurant-style meals—a good that is transparent in immediate pleasure (taste) but non-transparent in future harm (calories). Our results support the notion that strategic self-ignorance matters: nearly three of five...... subjects (58%) chose to ignore free information on calorie content, leading at-risk subjects to consume significantly more calories. We also find evidence consistent with our model on the determinants of strategic self-ignorance....

  1. Strategic Self-Ignorance

    DEFF Research Database (Denmark)

    Thunström, Linda; Nordström, Leif Jonas; Shogren, Jason F.;

    We examine strategic self-ignorance—the use of ignorance as an excuse to overindulge in pleasurable activities that may be harmful to one’s future self. Our model shows that guilt aversion provides a behavioral rationale for present-biased agents to avoid information about negative future impacts...... of such activities. We then confront our model with data from an experiment using prepared, restaurant-style meals — a good that is transparent in immediate pleasure (taste) but non-transparent in future harm (calories). Our results support the notion that strategic self-ignorance matters: nearly three of five...... subjects (58 percent) chose to ignore free information on calorie content, leading at-risk subjects to consume significantly more calories. We also find evidence consistent with our model on the determinants of strategic self-ignorance....

  2. Tourism and Strategic Planning

    DEFF Research Database (Denmark)

    Pasgaard, Jens Christian

    2012-01-01

    The main purpose of this report is to explore and unfold the complexity of the tourism phenomenon in order to qualify the general discussion of tourism-related planning challenges. Throughout the report I aim to demonstrate the strategic potential of tourism in a wider sense and more specifically...... the potential of ‘the extraordinary’ tourism-dominated space. As highlighted in the introduction, this report does not present any systematic analysis of strategic planning processes; neither does it provide any unequivocal conclusions. Rather, the report presents a collection of so-called ‘detours......’ – a collection of theoretical discussions and case studies with the aim to inspire future strategic planning. Due to the complexity and heterogeneity of the phenomenon I use a non-linear and non-chronological report format with the ambition to create a new type of overview. In this regard the report is intended...

  3. Strategic environmental assessment

    DEFF Research Database (Denmark)

    Kørnøv, Lone

    1997-01-01

    The integration of environmental considerations into strategic decision making is recognized as a key to achieving sustainability. In the European Union a draft directive on Strategic Environmental Assessment (SEA) is currently being reviewed by the member states. The nature of the proposed SEA...... directive is outlined, together with its relationship with the process of spatial planning and public participation in Denmark. This paper analyses the adoption of the proposed directive and discusses whether the SEA is an appropriate tool for opening and democratizing political structures. It concludes...

  4. Immunomodulating and antiviral therapy in herpes zoster.

    Science.gov (United States)

    Topciu, V; Mihăilescu, R

    1996-01-01

    Two groups of patients with herpes zoster were followed up. The first group was subjected, beside a symptomatic therapy, to an immunological and antiviral treatment. The control group was treated only symptomatically. The immunological preparations used were: the immunostimulant SRE (Corynebacterium parvum), which stimulated the lymphocytes and macrophages, Moroxidin (Virustat-Paris) and Antiherpin (interferon inductor), which acted by blocking the virus replication. The preparations were indigenous and atoxic. A significant difference between the courses of disease in the two groups was observed, namely, the severity and duration of subjective and objective symptoms were more than double and followed by persistent neurological sequelae in the control group in comparison with the patients of the experimental group. PMID:9495784

  5. Novel concept on antiviral strategies to dengue.

    Science.gov (United States)

    Lo, Yu-Chih; Perng, Guey Chuen

    2016-06-01

    Recent evidence has revealed that asymptomatic and/or persistent dengue virus (DENV) infections play a role in the cycling pattern of dengue outbreaks. These findings add a new dimension to the continually evolving search for effective prevention strategies in dengue. Disappointing outcomes of clinical trials in anti-dengue modalities have become commonplace. These failures may result from confounding variables and/or unresolved scientific issues that surround dengue, including the replication cycle of DENV in a natural setting, the target cells and reservoir for viral replication in vivo, and the effect of asymptomatic/persistent carriers in the dissemination of dengue. This article sets forth to address these issues using the most updated information available in the literature and to propose a novel antiviral strategy for the prevention and control of dengue. PMID:27284691

  6. RNAi:antiviral therapy against dengue virus

    Institute of Scientific and Technical Information of China (English)

    Sobia Idrees; Usman A Ashfaq

    2013-01-01

    Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.

  7. Mapping strategic diversity: strategic thinking from a variety of perspectives

    NARCIS (Netherlands)

    D. Jacobs

    2010-01-01

    In his influential work, Strategy Safari, Henry Mintzberg and his colleagues presented ten schools of strategic thought. In this impressive book, Dany Jacobs demonstrates that the real world of strategic management is much wider and richer. In Mapping Strategic Diversity, Jacobs distinguishes betwee

  8. Corporate strategic plan for safeguards and security

    International Nuclear Information System (INIS)

    Department of Energy (DOE) safeguards and security (S and S) is a team effort, consisting of Field, National Laboratories, Program Office, and Headquarters units cooperating to support the Department's diverse security needs. As an integral part of the nation's security structure, the DOE S and S Program regularly supports and works in cooperation with other US Government agencies and private industry to improve the national security posture. Thus, inter- and intra-agency partnerships play an invaluable role in the continuing efforts to integrate and implement improved ways of doing business. Their Corporate Strategic Plan provides a road map to guide, track, and provide feedback for the incorporation and implementation of S and S activities within DOE. Part 1 Planning Framework, describes those overarching factors which influence the planning endeavors. Part 2, Strategic Perspective, outlines where the S and S Program has been and how they will move to the future through core competencies, changing cultural thinking, and implementing their strategies. Part 3, Strategic and Operational Integration, details critical focus areas, strategies, and success indicators designed to enhance inter-agency S and S integration and promote cooperation with external agencies. This Plan will be reviewed annually to ensure it remains supportive and fully-engaged with the nation's and international security environments

  9. Antifungal and antiviral products of marine organisms.

    Science.gov (United States)

    Cheung, Randy Chi Fai; Wong, Jack Ho; Pan, Wen Liang; Chan, Yau Sang; Yin, Cui Ming; Dan, Xiu Li; Wang, He Xiang; Fang, Evandro Fei; Lam, Sze Kwan; Ngai, Patrick Hung Kui; Xia, Li Xin; Liu, Fang; Ye, Xiu Yun; Zhang, Guo Qing; Liu, Qing Hong; Sha, Ou; Lin, Peng; Ki, Chan; Bekhit, Adnan A; Bekhit, Alaa El-Din; Wan, David Chi Cheong; Ye, Xiu Juan; Xia, Jiang; Ng, Tzi Bun

    2014-04-01

    Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (-)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (-)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1-5 (TH 1-5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the aforementioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of

  10. Macrofoundation for Strategic Technology Management

    DEFF Research Database (Denmark)

    Pedersen, Jørgen Lindgaard

    1995-01-01

    Neoclassical mainstream economics has no perspective on strategic technology management issues. Market failure economics (externalities etc.)can be of some use to analyze problems of relevance in strategic management problems with technology as a part. Environment, inequality and democratic...

  11. Strategic Marketing for Presidents.

    Science.gov (United States)

    Pappas, Richard J., Ed.

    Designed to inform the marketing efforts of community college presidents, this document describes the importance of marketing, presents a targeted approach, and outlines the specific roles and skills needed by the president to ensure successful efforts and effective institutions. The first chapter, "Developing a Marketing-Strategic Plan," by…

  12. The strategic research positioning:

    DEFF Research Database (Denmark)

    Viala, Eva Silberschmidt

    to provide new insights into ‘immigrant’ parents’ perspective on home/school partnership in Denmark. The majority of the immigrant parents came from non-Western countries, and they had already been ‘labelled’ difficult in terms of home/school partnership. This calls for what I call ‘strategic...

  13. Strategically Planning to Change

    Science.gov (United States)

    Atkins, Kemal

    2010-01-01

    Higher education, like the private sector, is searching for innovative ways to respond to demographic shifts, globalization, greater accountability, and new technologies. New organizational models are needed to meet these challenges. In a rapidly changing world, the development of such models can occur through effective strategic analysis and…

  14. Strategic Targeted Advertising

    NARCIS (Netherlands)

    A. Galeotti; J.L. Moraga-Gonzalez (José Luis)

    2003-01-01

    textabstractWe present a strategic game of pricing and targeted-advertising. Firms can simultaneously target price advertisements to different groups of customers, or to the entire market. Pure strategy equilibria do not exist and thus market segmentation cannot occur surely. Equilibria exhibit rand

  15. Strategic planning for marketers.

    Science.gov (United States)

    Wilson, I

    1978-12-01

    The merits of strategic planning as a marketing tool are discussed in this article which takes the view that although marketers claim to be future-oriented, they focus too little attention on long-term planning and forecasting. Strategic planning, as defined by these authors, usually encompasses periods of between five and twenty-five years and places less emphasis on the past as an absolute predictor of the future. It takes a more probabilistic view of the future than conventional marketing strategy and looks at the corporation as but one component interacting with the total environment. Inputs are examined in terms of environmental, social, political, technological and economic importance. Because of its futuristic orientation, an important tenant of strategic planning is the preparation of several alternative scenarios ranging from most to least likely. By planning for a wide-range of future market conditions, a corporation is more able to be flexible by anticipating the course of future events, and is less likely to become a captive reactor--as the authors believe is now the case. An example of strategic planning at General Elecric is cited.

  16. Strategic Tutor Monitoring.

    Science.gov (United States)

    Chee-kwong, Kenneth Chao

    1996-01-01

    Discusses effective tutor monitoring strategies based on experiences at the Open Learning Institute of Hong Kong. Highlights include key performance and strategic control points; situational factors, including tutor expectations and relevant culture; Theory X versus Theory Y leadership theories; and monitoring relationships with tutors. (LRW)

  17. Towards Strategic Language Learning

    NARCIS (Netherlands)

    Oostdam, R.; Rijlaarsdam, Gert

    1995-01-01

    Towards Strategic Language Learning is the result of extensive research in the relationship between mother tongue education and foreign language learning. As language skills that are taught during native language lessons are applied in foreign language performance as well, it is vital that curricula

  18. A Strategic Planning Workbook.

    Science.gov (United States)

    Austin, William

    This workbook outlines the Salem Community College's (New Jersey) Strategic Planning Initiative (SPI), which will enable the college to enter the 21st Century as an active agent in the educational advancement of the Salem community. SPI will allow college faculty, staff, students, and the local community to reflect on the vitality of the college…

  19. Strategic CSR in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer

    CSR is a rising phenomena in Afghanistan – but why are firms concerned about CSR in a least-developed context such as Afghanistan, and what are the strategic benefits? This paper is one of the first to explore these CSR issues in a least-developed country. It does so by focusing on CSR in the Afg......CSR is a rising phenomena in Afghanistan – but why are firms concerned about CSR in a least-developed context such as Afghanistan, and what are the strategic benefits? This paper is one of the first to explore these CSR issues in a least-developed country. It does so by focusing on CSR...... advantages through CSR in Afghanistan, and if so which and how these strategic benefits are gained. The paper shows that the developmental challenges of Afghanistan are the key explanations for why companies engage in CSR. Roshan has engaged in proactive CSR to overcome the contextual barriers for growth......’, but is based on a ‘license to operate’ motivation, where businesses have free room for maneuvering CSR towards their strategic priorities and business goals. Whether this creates a ‘shared value’ for both business and in particularly for the society is however still questionable....

  20. Naming as Strategic Communication:

    DEFF Research Database (Denmark)

    Schmeltz, Line; Kjeldsen, Anna Karina

    2016-01-01

    This article presents a framework for understanding corporate name change as strategic communication. From a corporate branding perspective, the choice of a new name can be seen as a wish to stand out from a group of similar organizations. Conversely, from an institutional perspective, name change...

  1. Using Collaborative Strategic Reading.

    Science.gov (United States)

    Klingner, Janette K.; Vaughn, Sharon

    1998-01-01

    Describes collaborative strategic reading (CSR), a technique for teaching students, such as those with learning disabilities, reading comprehension and vocabulary skills in a cooperative setting. Covers teaching the four strategies of CSR (preview, click and clunk, get the gist, and wrap up), as well as teaching students cooperative learning group…

  2. Strategic Alignment of Business Intelligence

    OpenAIRE

    Cederberg, Niclas

    2010-01-01

    This thesis is about the concept of strategic alignment of business intelligence. It is based on a theoretical foundation that is used to define and explain business intelligence, data warehousing and strategic alignment. By combining a number of different methods for strategic alignment a framework for alignment of business intelligence is suggested. This framework addresses all different aspects of business intelligence identified as relevant for strategic alignment of business intelligence...

  3. Strategic Mismatches in Competing Teams

    OpenAIRE

    Kräkel, Matthias

    1999-01-01

    This paper discusses the strategic role of mismatching, where players voluntarily form inefficient teams or forego the formation of efficient teams, respectively. Strategic mismatching can be rational when players realize a competitive advantage (e.g. harming other competitors). In addition, the results show that free riding can be beneficial for a team in combination with strategic mismatching and that the loser?s curse may be welfare improving by mitigating the problem of strategic mismatch...

  4. Strategic analysis of choosen subject

    OpenAIRE

    Gebhart, Ondřej

    2014-01-01

    Thesis "Strategic Analysis of the selected entity 'of the chosen subject is about strategy BRISK Tabor as The aim is to assess the strategic focus of the company, the discovery and propose changes in the current Strategy. The work is divided into a theoretical part and a practical part of the conclusion. The theoretical part is from the perspective of economic theory and practice is portrayed strategy, strategic management process, thinking and planning. Strategic analysis of the external and...

  5. Competing strategically through market orientation.

    Science.gov (United States)

    Rapert, M I; Yarbrough, L

    1997-01-01

    As organizations seek to better understand their customers, competitors, and environments, the marketing function effectively serves as the support mechanism for these activities in many industries. Accordingly, in many organizations the marketing concept has been elevated to the stature of a strategic weapon, manifested in the form of market orientation. Market-oriented firms emphasize the collection, organization, and dissemination of information regarding both customers and competitors. This strategy is especially well-suited for the health care industry where customer knowledge is of paramount importance, customer interaction is instantaneous, and customer satisfaction is essential. Results of a national study of general service hospitals suggest that firms which embrace a market orientation benefit through enhanced customer satisfaction and quality.

  6. Competing strategically through market orientation.

    Science.gov (United States)

    Rapert, M I; Yarbrough, L

    1997-01-01

    As organizations seek to better understand their customers, competitors, and environments, the marketing function effectively serves as the support mechanism for these activities in many industries. Accordingly, in many organizations the marketing concept has been elevated to the stature of a strategic weapon, manifested in the form of market orientation. Market-oriented firms emphasize the collection, organization, and dissemination of information regarding both customers and competitors. This strategy is especially well-suited for the health care industry where customer knowledge is of paramount importance, customer interaction is instantaneous, and customer satisfaction is essential. Results of a national study of general service hospitals suggest that firms which embrace a market orientation benefit through enhanced customer satisfaction and quality. PMID:10179668

  7. STRATEGIC CONTROLLING IMPLEMENTATION IN MOLDOVAN BAKERY INDUSTRY

    Directory of Open Access Journals (Sweden)

    Maria Oleiniuc

    2012-03-01

    Full Text Available Strategic controlling is a strategic management subsystem that coordinates the functionsof strategic analysis, training objectives, planning and strategy correction, controls the operation of theentire system and well as develops and monitors the strategic informational assurance subsystem.

  8. Being Strategic in HE Management

    Science.gov (United States)

    West, Andrew

    2008-01-01

    The call to be strategic--and with it the concept of strategic management--can bring to mind a wide range of definitions, and there is now a huge array of academic literature supporting the different schools of thought. At a basic level, however, strategic thinking is probably most simply about focusing on the whole, rather than the part. In…

  9. Peaceful Development and Strategic Opportunity

    Institute of Scientific and Technical Information of China (English)

    Yang Yi

    2006-01-01

    @@ The international strategic situation and environment China faces have changed dramatically since September 11. China has closely followed and adapted itself to the ever-changing situation, seized strategic opportunity, adjusted its global strategy, adhered to peaceful development and displayed diplomacy and strategic flexibility. These are manifested in the following four aspects:

  10. Strategic Partnerships in Higher Education

    Science.gov (United States)

    Ortega, Janet L.

    2013-01-01

    The purpose of this study was to investigate the impacts of strategic partnerships between community colleges and key stakeholders; to specifically examine strategic partnerships; leadership decision-making; criteria to evaluate strategic partnerships that added value to the institution, value to the students, faculty, staff, and the local…

  11. Strategic market planning for hospitals.

    Science.gov (United States)

    Zallocco, R L; Joseph, W B; Doremus, H

    1984-01-01

    The application of strategic market planning to hospital management is discussed, along with features of the strategic marketing management process. A portfolio analysis tool, the McKinsey/G.E. Business Screen, is presented and, using a large urban hospital as an example, discussed in detail relative to hospital administration. Finally, strategic implications of the portfolio analysis are examined.

  12. The Possibilities of Strategic Finance

    Science.gov (United States)

    Chaffee, Ellen

    2010-01-01

    Strategic finance is aligning financial decisions--regarding revenues, creating and maintaining institutional assets, and using those assets--with the institution's mission and strategic plan. The concept known as "strategic finance" increasingly is being seen as a useful perspective for helping boards and presidents develop a sustainable…

  13. Strategic Management of Large Projects

    Institute of Scientific and Technical Information of China (English)

    WangYingluo; LiuYi; LiYuan

    2004-01-01

    The strategic management of large projects is both theoretically and practically important. Some scholars have advanced flexible strategy theory in China. The difference of strategic flexibility and flexible strategy is pointed out. The supporting system and characteristics of flexible strategy are analyzed. The changes of flexible strategy and integration of strategic management are discussed.

  14. Strategic Planning and Financial Management

    Science.gov (United States)

    Conneely, James F.

    2010-01-01

    Strong financial management is a strategy for strategic planning success in student affairs. It is crucial that student affairs professionals understand the necessity of linking their strategic planning with their financial management processes. An effective strategic planner needs strong financial management skills to implement the plan over…

  15. The strategic entrepreneurial thinking imperative

    Directory of Open Access Journals (Sweden)

    S. Dhliwayo

    2007-12-01

    Full Text Available Purpose: The aim of this paper is to demonstrate that strategic entrepreneurial thinking is a unitary concept which should be viewed as a standalone construct. Design/Methodology/Approach: The concept strategic entrepreneurial thinking is modelled from an analysis of strategic thinking and entrepreneurial thinking from available literature. The strategic entrepreneurial mindset imperative is then emphasised and confirmed. Findings: This paper's finding is that there is no difference between strategic thinking and the entrepreneurial mindset. Instead, the composite strategic entrepreneurial mindset construct should be treated as a unitary construct. Practical implications: The importance for practitioners is that the paper integrates two constructs, strategic thinking and entrepreneurial thinking into a new concept, strategic entrepreneurial thinking. The paper shows how difficult it is to split this thinking and behaviour into separate strategic and entrepreneurial thought and action processes. Originality/Value: The paper explores the ''thinking'' aspect of the strategic entrepreneurial concept which prominent authors on the strategic entrepreneurship topic seem to have not focused on. The resultant strategic entrepreneurial mindset is modelled into a new stand alone concept on its own.

  16. Strategic Partnership: Potential for Ensuring the University Sustainable Development

    Directory of Open Access Journals (Sweden)

    Tatiana Salimova

    2014-07-01

    Full Text Available The purpose of the article is to research the theoretical approaches to strategic partnerships of universities, analyse the current trends of partnership development of universities in the context of sustainable development, discuss the experience of the National Research Ogarev Mordovia State University in terms of strategic partnerships creation and define the new opportunities of developing the strategic partnerships. The methodology of the paper is based on comprehensive literature review in the sphere of university partnerships. The authors use a comparative method, analysis and summarizing aimed on defining the current trends and issues related to strategic partnership. There has been developed the partnership commitment chart of key stakeholders of universities to show current points and target points. The research findings are generalization of the strategic partnership theory with the focus on university activities in reference to sustainable development, clarification of current trends and issues of university strategic partnership, definition of further opportunities and methods in the area under consideration. Under modern conditions it is extremely important to develop a strategic partnership in the sphere of higher education. Universities are open institutions and they need to be involved into different processes of economy and society development. Article’s significance is in a new view on strategic partnership in the context of sustainable development of universities.

  17. Antiviral Treatment among Pregnant Women with Chronic Hepatitis B

    OpenAIRE

    Lin Fan; Kwame Owusu-Edusei; Schillie, Sarah F.; Murphy, Trudy V.

    2014-01-01

    Objective. To describe the antiviral treatment patterns for chronic hepatitis B (CHB) among pregnant and nonpregnant women. Methods. Using 2011 MarketScan claims, we calculated the rates of antiviral treatment among women (aged 10–50 years) with CHB. We described the pattern of antiviral treatment during pregnancy and ≥1 month after delivery. Results. We identified 6274 women with CHB during 2011. Among these, 64 of 507 (12.6%) pregnant women and 1151 of 5767 (20.0%) nonpregnant women receiv...

  18. Using a Dynamic Model to Consider Optimal Antiviral Stockpile Size in the Face of Pandemic Influenza Uncertainty

    Science.gov (United States)

    Greer, Amy L.; Schanzer, Dena

    2013-01-01

    Background The Canadian National Antiviral Stockpile (NAS) contains treatment for 17.5% of Canadians. This assumes no concurrent intervention strategies and no wastage due to non-influenza respiratory infections. A dynamic model can provide a mechanism to consider complex scenarios to support decisions regarding the optimal NAS size under uncertainty. Methods We developed a dynamic model for pandemic influenza in Canada that is structured by age and risk to calculate the demand for antivirals to treat persons with pandemic influenza under a wide-range of scenarios that incorporated transmission dynamics, disease severity, and intervention strategies. The anticipated per capita number of acute respiratory infections due to viruses other than influenza was estimated for the full pandemic period from surveys based on criteria to identify potential respiratory infections. Results Our results demonstrate that up to two thirds of the population could develop respiratory symptoms as a result of infection with a pandemic strain. In the case of perfect antiviral allocation, up to 39.8% of the population could request antiviral treatment. As transmission dynamics, severity and timing of the emergence of a novel influenza strain are unknown, the sensitivity analysis produced considerable variation in potential demand (median: 11%, IQR: 2–21%). If the next pandemic strain emerges in late spring or summer and a vaccine is available before the anticipated fall wave, the median prediction was reduced to 6% and IQR to 0.7–14%. Under the strategy of offering empirical treatment to all patients with influenza like symptoms who present for care, demand could increase to between 65 and 144%. Conclusions The demand for antivirals during a pandemic is uncertain. Unless an accurate, timely and cost-effective test is available to identify influenza cases, demand for antivirals from persons infected with other respiratory viruses will be substantial and have a significant impact on the

  19. Using a Dynamic Model to Consider Optimal Antiviral Stockpile Size in the Face of Pandemic Influenza Uncertainty.

    Directory of Open Access Journals (Sweden)

    Amy L Greer

    Full Text Available The Canadian National Antiviral Stockpile (NAS contains treatment for 17.5% of Canadians. This assumes no concurrent intervention strategies and no wastage due to non-influenza respiratory infections. A dynamic model can provide a mechanism to consider complex scenarios to support decisions regarding the optimal NAS size under uncertainty.We developed a dynamic model for pandemic influenza in Canada that is structured by age and risk to calculate the demand for antivirals to treat persons with pandemic influenza under a wide-range of scenarios that incorporated transmission dynamics, disease severity, and intervention strategies. The anticipated per capita number of acute respiratory infections due to viruses other than influenza was estimated for the full pandemic period from surveys based on criteria to identify potential respiratory infections.Our results demonstrate that up to two thirds of the population could develop respiratory symptoms as a result of infection with a pandemic strain. In the case of perfect antiviral allocation, up to 39.8% of the population could request antiviral treatment. As transmission dynamics, severity and timing of the emergence of a novel influenza strain are unknown, the sensitivity analysis produced considerable variation in potential demand (median: 11%, IQR: 2-21%. If the next pandemic strain emerges in late spring or summer and a vaccine is available before the anticipated fall wave, the median prediction was reduced to 6% and IQR to 0.7-14%. Under the strategy of offering empirical treatment to all patients with influenza like symptoms who present for care, demand could increase to between 65 and 144%.The demand for antivirals during a pandemic is uncertain. Unless an accurate, timely and cost-effective test is available to identify influenza cases, demand for antivirals from persons infected with other respiratory viruses will be substantial and have a significant impact on the NAS.

  20. Patent Examination Decisions and Strategic Trade Behavior

    OpenAIRE

    Alfons Palangkaraya; Paul Jensen; Elizabeth Webster

    2006-01-01

    This paper examines whether strategic trade behavior can explain the fact that the US, Japanese and European Patent Offices – the USPTO, the JPO and the EPO – often make different decisions about whether to grant (or reject) a given patent application. We analyse this issue by considering whether examination decisions across the patent offices vary systematically by inventor nationality, patent quality and technology area using a matched sample of 33,305 non-PCT patent applications granted ...

  1. Communication satellites: Guidelines for a strategic plan

    Science.gov (United States)

    1987-01-01

    To maintain and augment the leadership that the United States has enjoyed and to ensure that the nation is investing sufficiently and wisely to this purpose, a strategic plan for satellite communications research and development was prepared by NASA. Guidelines and recommendations for a NASA plan to support this objective and for the conduct of communication satellite research and development program over the next 25 years were generated. The guidelines are briefly summarized.

  2. Sustainable Development Strategy: A Tool for Strategic Governance?

    Directory of Open Access Journals (Sweden)

    Zuzana Drhová

    2011-12-01

    Full Text Available In a historical overview, the preparation process of the Sustainable Development Strategy in the Czech Republic is illustrated as continuous learning by all stakeholders, on the one hand, facing institutional and personal limits of public administration’s capacity for strategic governance, on the other hand. The main positive output of preparing the SDS in the Czech Republic has been the strengthening of the institutional and individual capacities for strategic governance among all involved stakeholders (including ministries. These capacities are then applied in agendas such as the cohesion policy and preparation of the National Strategic Framework 2014–2020.

  3. Intelligent National Strategy

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    China has unveiled a strategic plan aimed at strengthening I PR protection and enhancing the country’s overall competitiveness China’s State Council published the Outline of the National Intellectual Property Strategy in early June, taking on one of the country’s major bugbears. The plan aims to improve the use of intellectual property rights (IPR) by 2020 and consists of a preface, guiding prin- ciples and strategic goals, strategic focuses,

  4. Strategic Management and Business Analysis

    CERN Document Server

    Williamson, David; Jenkins, Wyn; Moreton, Keith Michael

    2003-01-01

    Strategic Business Analysis shows students how to carry out a strategic analysis of a business, with clear guidelines on where and how to apply the core strategic techniques and models that are the integral tools of strategic management.The authors identify the key questions in strategic analysis and provide an understandable framework for answering these questions.Several case studies are used to focus understanding and enable a more thorough analysis of the concepts and issues, especially useful for students involved with case study analysis.Accompanying the text is a CD-Rom containing the m

  5. Strategizing Communication. Theory and Practice

    DEFF Research Database (Denmark)

    Gulbrandsen, Ib Tunby; Just, Sine Nørholm

    Strategizing Communication offers a unique perspective on the theory and practice of strategic communication. Written for students and practitioners interested in learning about and acquiring tools for dealing with the technological, environmental and managerial challenges, which organizations face...... when communicating in today’s mediascape, this book presents an array of theories, concepts and models through which we can understand and practice communication strategically. The core of the argument is in the title: strategizing – meaning the act of making something strategic. This entails looking...

  6. Strategic and professional leadership : the challenge of role duality

    OpenAIRE

    Weight, Pauline

    2001-01-01

    In 1983 the National Health Service in England moved from a functional to a general management philosophy. This fundamental change gained momentum with the introduction of NHS Trusts in the early 1990s. Since this period, clinicians have taken a greater role in the strategic leadership of their organisations. This research considers the role of senior doctors (consultants) who have taken up a strategic leadership role alongside their clinical role (role duality). This is a q...

  7. Strategic Tax Competition; Implications of National Ownership

    OpenAIRE

    Olsen, Trond E.; Osmundsen, Petter

    2000-01-01

    Two jurisdictions compete to capture the rents of a large multinational enterprise (MNE) which invests locally and which is partly owned by local investors. The MNE contributes to local welfare by tax payments and dividends, and it has private information about the efficiency of the operations in the two localisations. It is shown that the distortions in the MNE's real investment portfolio are determined by a trade-off between fiscal externalities and equity externalities, and that investment...

  8. Los Alamos National Laboratory strategic directions

    Energy Technology Data Exchange (ETDEWEB)

    Hecker, S. [Los Alamos National Lab., NM (United States)

    1995-10-01

    It is my pleasure to welcome you to Los Alamos. I like the idea of bringing together all aspects of the research community-defense, basic science, and industrial. It is particularly important in today`s times of constrained budgets and in fields such as neutron research because I am convinced that the best science and the best applications will come from their interplay. If we do the science well, then we will do good applications. Keeping our eye focused on interesting applications will spawn new areas of science. This interplay is especially critical, and it is good to have these communities represented here today.

  9. Strategizing Communication. Theory and Practice

    DEFF Research Database (Denmark)

    Gulbrandsen, Ib Tunby; Just, Sine Nørholm

    Strategizing Communication offers a unique perspective on the theory and practice of strategic communication. Written for students and practitioners interested in learning about and acquiring tools for dealing with the technological, environmental and managerial challenges, which organizations face...... when communicating in today’s mediascape, this book presents an array of theories, concepts and models through which we can understand and practice communication strategically. The core of the argument is in the title: strategizing – meaning the act of making something strategic. This entails looking...... beyond, but not past instrumental, rational plans in order to become better able to understand and manage the concrete, incremental practices and contexts in which communication becomes strategic. Thus, we argue that although strategic communicators do (and should) make plans, a plan in itself does...

  10. The antiviral response to gamma interferon.

    Science.gov (United States)

    Costa-Pereira, Ana P; Williams, Timothy M; Strobl, Birgit; Watling, Diane; Briscoe, James; Kerr, Ian M

    2002-09-01

    A role for alpha/beta interferon (IFN-alpha/beta) in the IFN-gamma antiviral response has long been suggested. Accordingly, possible roles for autocrine or double-stranded-RNA (dsRNA)-induced IFN-alpha/beta in the IFN-gamma response were investigated. Use was made of wild-type and a variety of mutant human fibrosarcoma cell lines, including mutant U5A cells, which lack a functional IFN-alpha/beta receptor and hence an IFN-alpha/beta response. IFN-gamma did not induce detectable levels of IFN-alpha/beta in any of the cell lines, nor was the IFN-gamma response per se dependent on autocrine IFN-alpha/beta. On the other hand, a number of responses to dsRNA [poly(I). poly(C)] and encephalomyocarditis virus were greatly enhanced by IFN-gamma pretreatment (priming) of wild-type cells or of mutant cells lacking an IFN-alpha/beta response; these include the primary induction of dsRNA-inducible mRNAs, including IFN-beta mRNA, and, to a lesser extent, the dsRNA-mediated activation of the p38 mitogen-activated protein (MAP) kinase(s). IFN-gamma priming of mRNA induction by dsRNA is dependent on JAK1 and shows biphasic kinetics, with an initial rapid (<30-min) response being followed by a more substantial effect on overnight incubation. The IFN-gamma-primed dsRNA responses appear to be subject to modulation through the p38, phosphatidylinositol 3-kinase, and ERK1/ERK2 MAP kinase pathways. It can be concluded that despite efficient priming of IFN-beta production, the IFN-alpha/beta pathways play no significant role in the primary IFN-gamma antiviral response in these cell-virus systems. The observed IFN-gamma priming of dsRNA responses, on the other hand, will likely play a significant role in combating virus infection in vivo.

  11. Nation

    DEFF Research Database (Denmark)

    Østergaard, Uffe

    2014-01-01

    Nation er et gammelt begreb, som kommer af det latinske ord for fødsel, natio. Nationalisme bygger på forestillingen om, at mennesker har én og kun én national identitet og har ret til deres egen nationalstat. Ordet og forestillingen er kun godt 200 år gammel, og i 1900-tallet har ideologien bredt...... sig over hele verden. Nationalisme er blevet global....

  12. Conflict Resolution in Organization through Strategic Management

    Directory of Open Access Journals (Sweden)

    F. Zafar

    2014-02-01

    Full Text Available This study reveals the conflict Resolution in organization through Strategic management. There are different causes of conflicts within Organization and impact of conflicts on organization performance. The past decade researches identify the negative relation of conflict with employee performance. The research methodology was case study approach of different National and Multinational companies. The aim of study is to alleviate conflicts in organization through strategic management for enhancing organizational performance and managing change in order to attain competitive edge in this dynamic era. This paper covers the role of strategic management in resolving and minimizing conflict that brings positive impact on organization. Conflict in the workplace just seems to be a fact of life. The fact that conflict exists, however, is not necessarily a bad thing: As long as it is resolved effectively, it can lead to personal and professional growth. Conflict in the workplace is a painful reality and a key reason for poor productivity and frustration. Conflict does not magically go away and only gets worse when ignored. So to resolve conflicts strategic management is important.

  13. Dengue Virus Entry as Target for Antiviral Therapy

    Directory of Open Access Journals (Sweden)

    Marijke M. F. Alen

    2012-01-01

    Full Text Available Dengue virus (DENV infections are expanding worldwide and, because of the lack of a vaccine, the search for antiviral products is imperative. Four serotypes of DENV are described and they all cause a similar disease outcome. It would be interesting to develop an antiviral product that can interact with all four serotypes, prevent host cell infection and subsequent immune activation. DENV entry is thus an interesting target for antiviral therapy. DENV enters the host cell through receptor-mediated endocytosis. Several cellular receptors have been proposed, and DC-SIGN, present on dendritic cells, is considered as the most important DENV receptor until now. Because DENV entry is a target for antiviral therapy, various classes of compounds have been investigated to inhibit this process. In this paper, an overview is given of all the putative DENV receptors, and the most promising DENV entry inhibitors are discussed.

  14. STUDY OF ANTIVIRAL ACTIVITY OF SOME HYDRAZONE PINOSTROBIN DERIVATIVES

    Directory of Open Access Journals (Sweden)

    G. K. Mukusheva

    2014-01-01

    Full Text Available New derivatives on the basis of hydrazone pinostrobin molecule were synthesized. Significant antiviral activity of received samples of new hydrazone pinstrobin derivatives was identified.

  15. Regulation of antiviral innate immunity by deubiquitinase CYLD

    Institute of Scientific and Technical Information of China (English)

    Minying Zhang; Andrew J Lee; Xuefeng Wu; Shao-Cong Sun

    2011-01-01

    An antiviral innate immune response involves induction of type Ⅰ interferons (IFNs) and their subsequent autocrine and paracrine actions,but the underlying regulatory mechanisms are incompletely understood.Here we report that CYLD,a deubiquitinase that specifically digests lysine 63-1inked ubiquitin chains,is required for antiviral host defense.Loss of CYLD renders mice considerably more susceptible to infection by vesicular stomatitis virus (VSV).Consistently,CYLD-deficient dendritic cells are more sensitive to VSV infection.This functional defect was not due to lack of type I IFN production but rather because of attenuated IFN receptor signaling.In the absence of CYLD,IFN-β is ineffective in the induction of antiviral genes and protection of cells from viral infection.These findings establish CYLD as a novel regulator of antiviral innate immunity and suggest a role for CYLD in regulating IFN receptor signaling.

  16. The Strategic Mediator

    DEFF Research Database (Denmark)

    Rossignoli, Cecilia; Carugati, Andrea; Mola, Lapo

    2009-01-01

    The last 10 years have witnessed the emergence of electronic marketplaces as players that leverage new technologies to facilitate B2B internet-mediated collaborative business. Nowadays these players are augmenting their services from simple intermediation to include new inter-organizational relat......The last 10 years have witnessed the emergence of electronic marketplaces as players that leverage new technologies to facilitate B2B internet-mediated collaborative business. Nowadays these players are augmenting their services from simple intermediation to include new inter...... as an exclusive club, the belonging to which provides a strategic advantage. The technology brought forth by the marketplace participates in shaping the strategic demands of the participants which in turn request the marketplace to redesign its own strategy. Profiting from this unintended demand, the e...

  17. Current Strategic Business Plan for the Implementation of Digital Systems.

    Science.gov (United States)

    Library of Congress, Washington, DC. National Library Service for the Blind and Physically Handicapped.

    This document presents a current strategic business plan for the implementation of digital systems and services for the free national library program operated by the National Library Service for the Blind and Physically Handicapped, Library of Congress, its network of cooperating regional and local libraries, and the United States Postal Service.…

  18. THE SOUTH AFRICAN MILITARY IN TRANSITION: PART 2 – FROM STRATEGIC CULTURE TO STRATEGIC REALITY

    Directory of Open Access Journals (Sweden)

    Gerhard M Louw

    2014-11-01

    Full Text Available The analysis reported here focused on the dynamic interaction between a preferred strategic management model of the South African National Defence Force (SANDF on the one hand, and the SANDF’s acquired strategic culture on the other. From a theoretical perspective, the analysis draws attention to the fact that the properties of institutional culture inform the extent to which an organisation (such as the SANDF suffers the deleterious consequences of an inappropriate management model. The article therefore argues that the military’s lack of consensus on an appropriate political culture, the lack of a suitable social culture and the lack of an effective military culture have resulted in maintaining the continued viability of two discrete, concurrent strategic cultural paradigms in the SANDF: that of the defunct SADF (initially dominant, and that of the obsolete MK (currently governing. The uneasy co-existence of these two paradigms, each with its own worldview and value system, has confounded the efforts of the SANDF to form an appropriate intended strategy and to realise military effectiveness in its execution. A dichotomous strategic culture has, in effect, reinforced the weaknesses of the SANDF’s strategic management model, impeded organisational responsiveness, maximised organisational entropy, and encouraged the defence force’s systemic decline – the latter, a fact that the Defence Review 2014 specifically acknowledges in the discussion of the review’s first milestone. This part mainly employs deductive reasoning and draws its conclusions from a focused literary review.

  19. 3RDWHALE STRATEGIC ANALYSIS

    OpenAIRE

    Johnson, Andrew

    2009-01-01

    This essay provides a detailed strategic analysis of 3rdWhale, a Vancouver-based start-up in the sustainability sector, along with an analysis of the smartphone applications industry. Porter?s five forces model is used to perform an industry analysis of the smartphone application industry and identify key success factors for application developers. Using the identified factors, 3rdWhale is compared to its indirect competitors to identify opportunities and threats and produce a range of strate...

  20. Strategic Leadership towards Sustainability

    OpenAIRE

    Robèrt, Karl-Henrik; Broman, Göran; Waldron, David; Ny, Henrik; Byggeth, Sophie; Cook, David; Johansson, Lena; Oldmark, Jonas; Basile, George; Haraldsson, Hördur V.

    2004-01-01

    The Master's programme named "Strategic Leadership Towards Sustainability" is offered at the Blekinge Institute of Technology (Blekinge Tekniska Högskola) in Karlskrona, Sweden. This Master's programme builds on four central themes: (1) four scientific principles for socio-ecological sustainability; (2) a planning methodology of "backcasting" based on those scientific principles for sustainability; (3) a five-level model for planning in complex systems, into which backcasting is incorporated ...

  1. L-Valine Ester of Cyclopropavir - a New Antiviral Prodrug

    OpenAIRE

    Wu, Zhimeng; Drach, John C.; Prichard, Mark N.; Yanachkova, Milka; Yanachkov, Ivan; Bowlin, Terry L.; Zemlicka, Jiri

    2009-01-01

    The L-Valine ester of antiviral agent cyclopropavir, valcyclopropavir (6), was synthesized and evaluated for antiviral properties. Prodrug (6) inhibited replication of HCMV virus (Towne and AD169 strain) in HFF cells to approximately the same extent as the parent drug cyclopropavir (5). Stability of 6 toward hydrolysis at pH 7.0 roughly corresponds to that of valganciclovir (2). Pharmacokinetic studies in mice established that the oral bioavailability of valcyclopropavir (6) was 95%.

  2. Antiviral resistance and the control of pandemic influenza.

    Directory of Open Access Journals (Sweden)

    Marc Lipsitch

    2007-01-01

    Full Text Available BACKGROUND: The response to the next influenza pandemic will likely include extensive use of antiviral drugs (mainly oseltamivir, combined with other transmission-reducing measures. Animal and in vitro studies suggest that some strains of influenza may become resistant to oseltamivir while maintaining infectiousness (fitness. Use of antiviral agents on the scale anticipated for the control of pandemic influenza will create an unprecedented selective pressure for the emergence and spread of these strains. Nonetheless, antiviral resistance has received little attention when evaluating these plans. METHODS AND FINDINGS: We designed and analyzed a deterministic compartmental model of the transmission of oseltamivir-sensitive and -resistant influenza infections during a pandemic. The model predicts that even if antiviral treatment or prophylaxis leads to the emergence of a transmissible resistant strain in as few as 1 in 50,000 treated persons and 1 in 500,000 prophylaxed persons, widespread use of antivirals may strongly promote the spread of resistant strains at the population level, leading to a prevalence of tens of percent by the end of a pandemic. On the other hand, even in circumstances in which a resistant strain spreads widely, the use of antivirals may significantly delay and/or reduce the total size of the pandemic. If resistant strains carry some fitness cost, then, despite widespread emergence of resistance, antivirals could slow pandemic spread by months or more, and buy time for vaccine development; this delay would be prolonged by nondrug control measures (e.g., social distancing that reduce transmission, or use of a stockpiled suboptimal vaccine. Surprisingly, the model suggests that such nondrug control measures would increase the proportion of the epidemic caused by resistant strains. CONCLUSIONS: The benefits of antiviral drug use to control an influenza pandemic may be reduced, although not completely offset, by drug resistance

  3. Diagnosis and antiviral intervention strategies for mitigating an influenza epidemic.

    Directory of Open Access Journals (Sweden)

    Robert Moss

    Full Text Available BACKGROUND: Many countries have amassed antiviral stockpiles for pandemic preparedness. Despite extensive trial data and modelling studies, it remains unclear how to make optimal use of antiviral stockpiles within the constraints of healthcare infrastructure. Modelling studies informed recommendations for liberal antiviral distribution in the pandemic phase, primarily to prevent infection, but failed to account for logistical constraints clearly evident during the 2009 H1N1 outbreaks. Here we identify optimal delivery strategies for antiviral interventions accounting for logistical constraints, and so determine how to improve a strategy's impact. METHODS AND FINDINGS: We extend an existing SEIR model to incorporate finite diagnostic and antiviral distribution capacities. We evaluate the impact of using different diagnostic strategies to decide to whom antivirals are delivered. We then determine what additional capacity is required to achieve optimal impact. We identify the importance of sensitive and specific case ascertainment in the early phase of a pandemic response, when the proportion of false-positive presentations may be high. Once a substantial percentage of ILI presentations are caused by the pandemic strain, identification of cases for treatment on syndromic grounds alone results in a greater potential impact than a laboratory-dependent strategy. Our findings reinforce the need for a decentralised system capable of providing timely prophylaxis. CONCLUSIONS: We address specific real-world issues that must be considered in order to improve pandemic preparedness policy in a practical and methodologically sound way. Provision of antivirals on the scale proposed for an effective response is infeasible using traditional public health outbreak management and contact tracing approaches. The results indicate to change the transmission dynamics of an influenza epidemic with an antiviral intervention, a decentralised system is required for

  4. RNA interference: Antiviral weapon and beyond

    Institute of Scientific and Technical Information of China (English)

    Quan-Chu Wang; Qing-He Nie; Zhi-Hua Feng

    2003-01-01

    RNA interference (RNAi) is a remarkable type of gene regulation based on sequence-specific targeting and degradation of RNA. The term encompasses related pathways found in a broad range of eukaryotic organisms, including fungi, plants, and animals. RNA interference is part of a sophisticated network of interconnected pathways for cellular defense, RNA surveillance, and development and it may become a powerful tool to manipulate gene expression experimentally. RNAi technology is currently being evaluated not only as an extremely powerful instrument for functional genomic analyses, but also as a potentially useful method to develop specific dsRNA based gene-silencing therapeutics.Several laboratories have been interested in using RNAi to control viral infection and many reports in Nature and in Cell show that short interfering (si) RNAs can inhibit infection by HIV-1, polio and hepatitis C viruses in a sequence-specific manner. RNA-based strategies for gene inhibition in mammalian cells have recently been described, which offer the promise of antiviral therapy.

  5. Antiviral Warrior-APOBEC3G

    Institute of Scientific and Technical Information of China (English)

    WU Xiao-xia; MA Yi-cai

    2005-01-01

    This paper is to further understand how APOBEC3G can defend the retroviruses and to find new approaches to AIDs (acquired immure deficiency syndrome).The viral infectivity factor (Vif) induces rapid degradation of APOBEC3G by ubiquitination, which is a proteosome-dependent pathway. Precisely speaking, only in the virus-producing cell Vif expression is necessary; in its absence, infection of a subsequent target cell terminates at a postentry step through the action of the human APOBEC3G antiviral mechanism. Vif protein has two domains: one binds to APOBEC3G and the other regulates the degradation of APOBEC3G by a conserved sequence, SLQ (Y/F) LA motif. Recently, the research on Vif has also revealed APOBEC3G is a novel component of innate immune system. In fact, APOBEC3G not only acts in DNA editing to block the replication of retroviruses such as HIV-1, but also is able to defend a wide spectrum of distantly related retroviruses and interferes with HBV through a different mechanism from HIV.

  6. ANTIVIRAL POTENTIAL OF MEDICINAL PLANTS: AN OVERVIEW

    Directory of Open Access Journals (Sweden)

    Ruwali Pushpa

    2013-06-01

    Full Text Available The term ‘Antiviral agents’ has been defined in very broad terms as substances other than a virus or virus containing vaccine or specific antibody which can produce either a protective or therapeutic effect to the clear detectable advantage of the virus infected host. The herbal medicine has a long traditional use and the major advantage over other medicines is their wide therapeutic window with rare side effects. There are some disadvantages of synthetic drugs like narrow therapeutic window and more importantly the various adverse side effects which occur quite frequently. Due to these disadvantages and other limitations, there is an increasing trend in the field of research for discovering new and noble drugs based on various herbal formulations. This review attempts to address the importance of developing therapeutic herbal formulations from various medicinal plants using the knowledge based on traditional system of medicines, the Ayurveda. Although natural products have been used by civilization since ancient times, only in recent decades has there been growing research into alternative therapies and the therapeutics use of natural products, especially those derived from plants. Plants synthesize and preserve a variety of biochemical products, many of which are extractable and used for various scientific investigations. Therefore, medicinal plants proved to be a major resort for the treatment of diseases and sicknesses by traditional healers in many societies.

  7. Ribozymes:an anti-viral agent

    Institute of Scientific and Technical Information of China (English)

    Asad U.Khan; Shahper N.Khan

    2008-01-01

    The discovery that RNA can act as an enzyme led Thomas Cech to win the Nobel Prize in Chemistry and led immediately to the next wave of attempts to find an effective RNA-based therapy.The tantalizing idea that RNA enzymes called trans-cleaving ribozymes enables them to act as potential antiviral and powerful tool for functional genomic studies.The efficacy of ribozyme function in a complex intracellular environment is depend-ent on the intracellular fate of the RNA that is being targeted.Recently,ribozymes have been used successfully to inhibit gene expression in a variety of biological systems in vitro and in vivo.Ribozyme has also been used successfully to combat many cases of viral infection,as clinical trial.Despite it needs to be investigated and explored as far as its structural and functional aspects are concern.In view of the significance of ribozyme in modern medicine,we reviewed the recent literature on general approach to control viral infection.

  8. CNES Strategic Plan 2001-2005

    Science.gov (United States)

    Janichewski, S.; Ben Aı̈m, H.

    2004-04-01

    CNES's latest strategic plan defines the French space agency's strategic focus and charts its course for the 2001-2005 timeframe. Based on a vision of how the space sector will evolve over the period up to 2010, the Strategic Plan sets out the agency's ambition for 2005: " CNES—space technology serving society". This ambition is structured around four challenges: Focusing actions on society's needs in three areas where space technology can make a major difference—environment, science and the information society and mobility. Building the foundation for success by ensuring competitive access to space and boosting basic research and technological innovation. Strengthening national and European synergies to ensure complementarity between: the ESA European framework, which is well adapted for major projects and the development of a European Space Strategy (ESS); and the national framework to support activities of national responsibility such as defence, science and technology development, and to improve competitiveness through direct international cooperation with other space agencies. Forging effective partnerships with its research and industry partners in Europe and France to enhance performance by: developing a service culture; building partnerships; concentrating on core competencies where it can most add value; improving skills and responsiveness in line with its strategic position; ensuring transparent and rigorous management of public funds. This Strategic Plan will be implemented in the 2001-2005 timeframe at all management levels. Implementation will be eased by the fact that the plan has been drawn up through a specific process designed to make internal management aware of the analysis underlying it. This will ensure that all stakeholders understand and appropriate the plan's orientations and thus play an active role in CNES' development. This process involved five successive steps: shared assessment of the space sector's evolution, providing a common

  9. Natural Products as Source of Potential Dengue Antivirals

    Directory of Open Access Journals (Sweden)

    Róbson Ricardo Teixeira

    2014-06-01

    Full Text Available Dengue is a neglected disease responsible for 22,000 deaths each year in areas where it is endemic. To date, there is no clinically approved dengue vaccine or antiviral for human beings, even though there have been great efforts to accomplish these goals. Several approaches have been used in the search for dengue antivirals such as screening of compounds against dengue virus enzymes and structure-based computational discovery. During the last decades, researchers have turned their attention to nature, trying to identify compounds that can be used as dengue antivirals. Nature represents a vast reservoir of substances that can be explored with the aim of discovering new leads that can be either used directly as pharmaceuticals or can serve as lead structures that can be optimized towards the development of new antiviral agents against dengue. In this review we describe an assortment of natural products that have been reported as possessing dengue antiviral activity. The natural products are organized into classes of substances. When appropriate, structure-activity relationships are outlined. The biological assays used to assess antiviral activity are briefly described.

  10. Perspective of Use of Antiviral Peptides against Influenza Virus.

    Science.gov (United States)

    Skalickova, Sylvie; Heger, Zbynek; Krejcova, Ludmila; Pekarik, Vladimir; Bastl, Karel; Janda, Jozef; Kostolansky, Frantisek; Vareckova, Eva; Zitka, Ondrej; Adam, Vojtech; Kizek, Rene

    2015-10-01

    The threat of a worldwide influenza pandemic has greatly increased over the past decade with the emergence of highly virulent avian influenza strains. The increased frequency of drug-resistant influenza strains against currently available antiviral drugs requires urgent development of new strategies for antiviral therapy, too. The research in the field of therapeutic peptides began to develop extensively in the second half of the 20(th) century. Since then, the mechanisms of action for several peptides and their antiviral prospect received large attention due to the global threat posed by viruses. Here, we discussed the therapeutic properties of peptides used in influenza treatment. Peptides with antiviral activity against influenza can be divided into three main groups. First, entry blocker peptides such as a Flupep that interact with influenza hemagglutinin, block its binding to host cells and prevent viral fusion. Second, several peptides display virucidal activity, disrupting viral envelopes, e.g., Melittin. Finally, a third set of peptides interacts with the viral polymerase complex and act as viral replication inhibitors such as PB1 derived peptides. Here, we present a review of the current literature describing the antiviral activity, mechanism and future therapeutic potential of these influenza antiviral peptides. PMID:26492266

  11. Perspective of Use of Antiviral Peptides against Influenza Virus

    Directory of Open Access Journals (Sweden)

    Sylvie Skalickova

    2015-10-01

    Full Text Available The threat of a worldwide influenza pandemic has greatly increased over the past decade with the emergence of highly virulent avian influenza strains. The increased frequency of drug-resistant influenza strains against currently available antiviral drugs requires urgent development of new strategies for antiviral therapy, too. The research in the field of therapeutic peptides began to develop extensively in the second half of the 20th century. Since then, the mechanisms of action for several peptides and their antiviral prospect received large attention due to the global threat posed by viruses. Here, we discussed the therapeutic properties of peptides used in influenza treatment. Peptides with antiviral activity against influenza can be divided into three main groups. First, entry blocker peptides such as a Flupep that interact with influenza hemagglutinin, block its binding to host cells and prevent viral fusion. Second, several peptides display virucidal activity, disrupting viral envelopes, e.g., Melittin. Finally, a third set of peptides interacts with the viral polymerase complex and act as viral replication inhibitors such as PB1 derived peptides. Here, we present a review of the current literature describing the antiviral activity, mechanism and future therapeutic potential of these influenza antiviral peptides.

  12. Space life sciences strategic plan

    Science.gov (United States)

    Nicogossian, Arnauld E.

    1992-01-01

    Over the last three decades the Life Sciences Program has significantly contributed to NASA's manned and unmanned exploration of space, while acquiring new knowledge in the fields of space biology and medicine. The national and international events which have led to the development and revision of NASA strategy will significantly affect the future of life sciences programs both in scope and pace. This document serves as the basis for synthesizing the options to be pursued during the next decade, based on the decisions, evolution, and guiding principles of the National Space Policy. The strategies detailed in this document are fully supportive of the Life Sciences Advisory Subcommittee's 'A Rationale for the Life Sciences,' and the recent Aerospace Medicine Advisory Committee report entitled 'Strategic Considerations for Support of Humans in Space and Moon/Mars Exploration Missions.' Information contained within this document is intended for internal NASA planning and is subject to policy decisions and direction, and to budgets allocated to NASA's Life Sciences Program.

  13. Age-prioritized use of antivirals during an influenza pandemic

    Directory of Open Access Journals (Sweden)

    Ajelli Marco

    2009-07-01

    Full Text Available Abstract Background The WHO suggested that governments stockpile, as part of preparations for the next influenza pandemic, sufficient influenza antiviral drugs to treat approximately 25% of their populations. Our aim is two-fold: first, since in many countries the antiviral stockpile is well below this level, we search for suboptimal strategies based on treatment provided only to an age-dependent fraction of cases. Second, since in some countries the stockpile exceeds the suggested minimum level, we search for optimal strategies for post-exposure prophylactic treatment of close contacts of cases. Methods We used a stochastic, spatially structured individual-based model, considering explicit transmission in households, schools and workplaces, to simulate the spatiotemporal spread of an influenza pandemic in Italy and to evaluate the efficacy of interventions based on age-prioritized use of antivirals. Results Our results show that the antiviral stockpile required for treatment of cases ranges from 10% to 35% of the population for R0 in 1.4 – 3. No suboptimal strategies, based on treatment provided to an age-dependent fraction of cases, were found able to remarkably reduce both clinical attack rate and antiviral drugs needs, though they can contribute to largely reduce the excess mortality. Treatment of all cases coupled with prophylaxis provided to younger individuals is the only intervention resulting in a significant reduction of the clinical attack rate and requiring a relatively small stockpile of antivirals. Conclusion Our results strongly suggest that governments stockpile sufficient influenza antiviral drugs to treat approximately 25% of their populations, under the assumption that R0 is not much larger than 2. In countries where the number of antiviral stockpiled exceeds the suggested minimum level, providing prophylaxis to younger individuals is an option that could be taken into account in preparedness plans. In countries where the

  14. ANTI-VIRAL ACTIVITY OF GLYCIRRHETINIC AND GLYCIRRHIZIC ACIDS

    Directory of Open Access Journals (Sweden)

    V. V. Zarubaev

    2016-01-01

    Full Text Available Influenza is a highly contagious human disease. In the course of use of antiviral drugs drug-resistant strains of the virus are formed, resulting in reduced efficiency of the chemotherapy. The review describes the biological activity of glycirrhetinic (GLA and glycirrhizic (GA acids in terms of their use as a therapeutic agent for viral infections. So, these compounds are against a broad spectrum of viruses, including herpes, corona-, alphaand flaviviruses, human immunodeficiency virus, vaccinia virus, poliovirus type I, vesicular stomatitis virus and influenza A virus. These data indicate that anti-viral effect of these compounds is due to several types of activity — direct antiviral effects, effects on cellular proand anti-viral and immunomodulating pathways, in particular by activation of innate immunity system. GA interferes with early steps of the viral reproductive cycle such as virus binding to its receptor, the absorption of the virus by endocytosis or virus decapsidation in the cytoplasm. This is due to the effect of GA-induced reduction of membrane fluidity. Thus, one mechanism for the antiviral activity of GA is that GA molecule increases the rigidity of cellular and viral membranes after incorporation in there. This results in increasing of energy threshold required for the formation of negative curvature at the fusion zones, as well as difficult lateral migration of the virus-receptor complexes. In addition, glycyrrhizin prevents interaction of viral nucleoprotein with cellular protein HMGB1, which is necessary for the viral life cycle. Glycyrrhizin also inhibits the induction of oxidative stress during influenza infection, exhibiting antioxidant properties, which leads to a reduction of virus-induced production of cytokines/chemokines, without affecting the replication of the virus. A wide spectrum of biological activity and effect on various aspects of the viral pathogenesis substantiate the effect of GA and GLA as a component

  15. Strategic materials: Technologies to reduce US import vulnerability

    Science.gov (United States)

    1985-05-01

    Three nations, South Africa, Zaire, and the U.S.S.R., account for over half of the world's production of chromium, cobalt, manganese, and platinum group metals. These metals are essential in the production of high-temperature alloys, steel and stainless steel, industrial and automotive catalysts, electronics, and other applications that are critical to the U.S. economy and the national defense. With minor exceptions, there is no domestic mine production of any of the four metals. Government actions to assure secure supplies of metals critical to the United States have been limited largely to reliance on the national defense stockpile to ensure the availability of materials required for national defense in time of war, leaving it to the free market to provide a diversity of suppliers for the industrial economy. An overall strategy to reduce U.S. reliance on uncertain sources of supply of strategic materials should be based on a combination of three technical approaches: increase the diversity of the world supply of strategic metals through the development of promising deposits; decrease demand for strategic metals through the implementation of improved manufacturing processes and recycling of strategic materials from scrap and waste; and identify and test substitute materials for current applications and develop new materials with reduced strategic material content for future applications.

  16. Antiviral effect of ranpirnase against Ebola virus.

    Science.gov (United States)

    Hodge, Thomas; Draper, Ken; Brasel, Trevor; Freiberg, Alexander; Squiquera, Luis; Sidransky, David; Sulley, Jamie; Taxman, Debra J

    2016-08-01

    The recent epidemic of Ebola has intensified the need for the development of novel antiviral therapeutics that prolong and improve survival against deadly viral diseases. We sought to determine whether ranpirnase, an endoribonuclease from Rana pipiens with a demonstrated human safety profile in phase III oncology trials, can reduce titers of Ebola virus (EBOV) in infected cells, protect mice against mouse-adapted EBOV challenge, and reduce virus levels in infected mice. Our results demonstrate that 0.50 μg/ml ranpirnase is potently effective at reducing EBOV Zaire Kikwit infection in cultured Vero E6 cells (Selectivity Index 47.8-70.2). In a prophylactic study, a single intravenous dose of 0.1 mg/kg ranpirnase protected 70% of mice from progressive infection. Additionally, in a post-exposure prophylactic study, 100% of female mice survived infection after intraperitoneal administration of 0.1 mg/kg ranpirnase for ten days beginning 1 h post challenge. Most of the male counterparts were sacrificed due to weight loss by Study Day 8 or 9; however, the Clinical Activity/Behavior scores of these mice remained low and no significant microscopic pathologies could be detected in the kidneys, livers or spleens. Furthermore, live virus could not be detected in the sera of ranpirnase-treated mice by Study Day 8 or in the kidneys, livers or spleens by Study Day 12, and viral RNA levels declined exponentially by Study Day 12. Because ranpirnase is exceptionally stable and has a long track record of safe intravenous administration to humans, this drug provides a promising new candidate for clinical consideration in the treatment of Ebola virus disease alone or in combination with other therapeutics. PMID:27350309

  17. Antiviral macrophage responses in flavivirus encephalitis.

    Science.gov (United States)

    Ashhurst, Thomas Myles; Vreden, Caryn van; Munoz-Erazo, Luis; Niewold, Paula; Watabe, Kanami; Terry, Rachael L; Deffrasnes, Celine; Getts, Daniel R; Cole King, Nicholas Jonathan

    2013-11-01

    Mosquito-borne flaviviruses are a major current and emerging threat, affecting millions of people worldwide. Global climate change, combined with increasing proximity of humans to animals and mosquito vectors by expansion into natural habitats, coupled with the increase in international travel, have resulted in significant spread and concomitant increase in the incidence of infection and severe disease. Although neuroinvasive disease has been well described for some viral infections such as Japanese Encephalitis virus (JEV) and West Nile virus (WNV), others such as dengue virus (DENV) have recently displayed an emerging pattern of neuroinvasive disease, distinct from the previously observed, systemically-induced encephalomyelopathy. In this setting, the immune response is a crucial component of host defence, in preventing viral dissemination and invasion of the central nervous system (CNS). However, subversion of the anti-viral activities of macrophages by flaviviruses can facilitate viral replication and spread, enhancing the intensity of immune responses, leading to severe immune-mediated disease which may be further exacerbated during the subsequent infection with some flaviviruses. Furthermore, in the CNS myeloid cells may be responsible for inducing specific inflammatory changes, which can lead to significant pathological damage during encephalitis. The interaction of virus and cells of the myeloid lineage is complex, and this interaction is likely responsible at least in part, for crucial differences between viral clearance and pathology. Recent studies on the role of myeloid cells in innate immunity and viral control, and the mechanisms of evasion and subversion used by flaviviruses are rapidly advancing our understanding of the immunopathological mechanisms involved in flavivirus encephalitis and will lead to the development of therapeutic strategies previously not considered. PMID:24434318

  18. Engineering strategic approach as organizational necessary

    Directory of Open Access Journals (Sweden)

    Nasser Fegh-hi Farahmand

    2013-01-01

    Full Text Available The article supports previous evidence that, even in host environments with high cultural distance and constraining employment frameworks, engineering planning, engineering are able to find room for engineering management maneuver. Specific attention paid to the transfer of the headquarters‘ flat organizational structure to a body of organizations with a noticeably hierarchical managerial system. This paper explore the ways in which certain characteristics in case of organizations generates a tendency to prepare a formal written engineering plan and focus is primarily on what describe as the environmental characteristics. Engineering excellence for strategic engineering includes also tools for financial, human resource, and risk management, as well as technology management, acquisitions and marketing. In other words, as has been suggested elsewhere, every national organizational system  even one as constrained engineering strategic approach as organizational necessary   contains some degree of malleability and openness which may be exploited through appropriate organization specific managerial strategies for engineering management.

  19. SYSTEM REFLEXIVE STRATEGIC MARKETING MANAGEMENT

    Directory of Open Access Journals (Sweden)

    A. Dligach

    2013-10-01

    Full Text Available This article reviews the System Reflexive paradigm of strategic marketing management, being based on the alignment of strategic economic interests of stakeholders, specifically, enterprise owners and hired managers, and consumers. The essence of marketing concept of management comes under review, along with the strategic management approaches to business, buildup and alignment of economic interests of business stakeholders. A roadmap for resolving the problems of modern marketing is proposed through the adoption of System Reflexive marketing theory.

  20. An Introduction to Strategic Communication

    OpenAIRE

    Thomas, Gail Fann; Stephens, Kimberlie J.

    2014-01-01

    The article of record as published may be located at http://dx.doi.org/10.1177/2329488414560469 Strategic communication is an emerging area of study in the communication and management social sciences. Recent academic conversations around this topic have appeared in publications such as the International Journal of Strategic Communication, which was established in 2007, and The Routledge Handbook of Strategic Communication, which will be published this year. Likewise, the discu...

  1. The Strategic Human Resource Management

    OpenAIRE

    Merthová, Hana

    2012-01-01

    This thesis deals with the topic " Strategic management of human resources." It is divided into two main parts, the theoretical and the practical. The theoretical part focuses on the characteristics and definition of terms related to issues of strategic human resources management and defining relationships between these concepts. In this part there is further processed one of the most important fields of strategic management of human resources in the company which is the education and per...

  2. STRATEGIC ENTREPRENEURSHIP IN FAMILY BUSINESS

    OpenAIRE

    G.T. LUMPKIN; L. STEIER; Wright, M

    2012-01-01

    The purpose of this special issue is to promote research on the role of family in nurturing entrepreneurial ventures as well as on the importance of strategic entrepreneurship in maintaining the strength and viability of established and multigenerational family firms. Two related research questions are at the heart of this inquiry: (1) In what ways does the influence of family matter to strategic entrepreneurship?; and (2) How can strategic entrepreneurship contribute to understanding and str...

  3. Strategic Human Resources Management

    Directory of Open Access Journals (Sweden)

    Marta Muqaj

    2016-07-01

    Full Text Available Strategic Human Resources Management (SHRM represents an important and sensitive aspect of the functioning and development of a company, business, institution, state, public or private agency of a country. SHRM is based on a point of view of the psychological practices, especially by investing on empowerment, broad training and teamwork. This way it remains the primary resource to maintain stability and competitiveness. SHRM has lately evolved on fast and secure steps, and the transformation from Management of Human Resources to SHRM is becoming popular, but it still remains impossible to exactly estimate how much SHRM has taken place in updating the practices of HRM in organizations and institutions in general. This manuscript aims to make a reflection on strategic management, influence factors in its practices on some organizations. Researchers aim to identify influential factors that play key roles in SHRM, to determine its challenges and priorities which lay ahead, in order to select the most appropriate model for achieving a desirable performance. SHRM is a key factor in the achievement of the objectives of the organization, based on HR through continuous performance growth, it’s a complex process, unpredictable and influenced by many outside and inside factors, which aims to find the shortest way to achieve strategic competitive advantages, by creating structure planning, organizing, thinking values, culture, communication, perspectives and image of the organization. While traditional management of HR is focused on the individual performance of employees, the scientific one is based on the organizational performance, the role of the HRM system as main factor on solving business issues and achievement of competitive advantage within its kind.

  4. Strategic planning and republicanism

    Directory of Open Access Journals (Sweden)

    Mazza Luigi

    2010-01-01

    Full Text Available The paper develops two main linked themes: (i strategic planning reveals in practice limits that are hard to overcome; (ii a complete planning system is efficacy only in the framework of a republican political, social and government culture. It is argued that the growing disappointment associated to strategic planning practices, may be due to excessive expectations, and the difficulties encountered by strategic planning are traced to three main issues: (a the relationship between politics and planning; (b the relationship between government and governance; and (c the relationship between space and socioeconomic development. Some authors recently supported an idea of development as consisting in the qualitative evolution of forms of social rationality and argued that a reflection about the relationships between physical transformations and visions of development could be a way of testing innovations. But such strong demands might be satisfied only if we manage to make a 'new social and territorial pact for development', recreating a social fabric imbued with shared values. The re-creation of a social fabric imbued with shared values requires a rich conception of the political community and the possibility that the moral purposes of the community may be incorporated by the state. All this is missing today. Outside a republican scheme planning activities are principally instruments for legitimising vested interests and facilitating their investments, and the resolution of the conflicts that arise between the planning decisions of the various levels of government becomes at least impracticable. A complete planning system can be practised if can be referred to the authority and syntheses expressed in and by statehood, which suggests that in a democratic system planning is republican by necessity rather than by choice.

  5. Strategizing y liderazgo

    OpenAIRE

    Marín Tuyá, Belén

    2013-01-01

    El desarrollo del strategizing, concepto introducido por Whittington (1996) que enfoca la estrategia en la práctica “cómo algo que las personas hacen”, surgió por la creciente insatisfacción con la investigación convencional en estrategia. Así mientras las personas realizaban la estrategia, las teorías se centraban en análisis multivariantes sobre los efectos de la estrategia en el rendimiento de la organización con una curiosa ausencia de los actores humanos. Con el objetivo de avanzar en el...

  6. Strategic Aspects of Bundling

    International Nuclear Information System (INIS)

    The increase of bundle supply has become widespread in several sectors (for instance in telecommunications and energy fields). This paper review relates strategic aspects of bundling. The main purpose of this paper is to analyze profitability of bundling strategies according to the degree of competition and the characteristics of goods. Moreover, bundling can be used as price discrimination tool, screening device or entry barriers. In monopoly case bundling strategy is efficient to sort consumers in different categories in order to capture a maximum of surplus. However, when competition increases, the profitability on bundling strategies depends on correlation of consumers' reservations values. (author)

  7. Beyond Strategic Vision

    CERN Document Server

    Cowley, Michael

    2012-01-01

    Hoshin is a system which was developed in Japan in the 1960's, and is a derivative of Management By Objectives (MBO). It is a Management System for determining the appropriate course of action for an organization, and effectively accomplishing the relevant actions and results. Having recognized the power of this system, Beyond Strategic Vision tailors the Hoshin system to fit the culture of North American and European organizations. It is a "how-to" guide to the Hoshin method for executives, managers, and any other professionals who must plan as part of their normal job. The management of an o

  8. Guam Strategic Energy Plan

    Energy Technology Data Exchange (ETDEWEB)

    Conrad, M. D.

    2013-07-01

    Describes various energy strategies available to Guam to meet the territory's goal of diversifying fuel sources and reducing fossil energy consumption 20% by 2020.The information presented in this strategic energy plan will be used by the Guam Energy Task Force to develop an energy action plan. Available energy strategies include policy changes, education and outreach, reducing energy consumption at federal facilities, and expanding the use of a range of energy technologies, including buildings energy efficiency and conservation, renewable electricity production, and alternative transportation. The strategies are categorized based on the time required to implement them.

  9. Strategic Urban Governance

    DEFF Research Database (Denmark)

    Pagh, Jesper

    2014-01-01

    The days of long-term predict-and-provide planning that saw its heydays in the post-war decades are long gone. As our late-modern time presents us with an evermore complex and contrasting view of the world, planning has become a much more fragmented and ambivalent affair. That a country or a city...... should be run like a private corporation has increasingly become common sense, and thus the competition among entities – be it countries, regions or cities – to a greater and greater extent defines success and the means to achieve it. What has been collected under the umbrella term Strategic Urban...

  10. Developing strategic plans for effective utilization of research reactors

    Energy Technology Data Exchange (ETDEWEB)

    Ridikas, Danas [International Atomic Energy Agency, Vienna (Austria). Dept. of Nuclear Sciences and Applications

    2015-12-15

    Strategic plans are indispensable documents for research reactors (RRs) to ensure their efficient, optimized and well managed utilization. A strategic plan provides a framework for increasing utilization, while helping to create a positive safety culture, a motivated staff, a clear understanding of real costs and a balanced budget. A strategic plan should be seen as an essential tool for a responsible manager of any RR, from the smallest critical facility to the largest reactor. Results and lessons learned are shown from the IAEA efforts to help the RR facilities developing strategic plans, provide review and advise services, organize national and regional stakeholder/user workshops, prepare further guidance and recommendations, document and publish guidance documents and other supporting materials.

  11. EU Strategic Culture and the 2011 Libyan War

    DEFF Research Database (Denmark)

    Kahlke Hansen, Lea; Nielsen, Kristian L.

    in Libya in many ways seemed an ideal opportunity for the EU to manifest itself as an important security actor, and to fullfill its strategic ambitions as they are described in the 2003 European Security Strategy. Instead, due to internal disagreements on the use of force, the EU was unable to forge...... a common position of any importance and therefore once again remained peripheral. This article examines the strategic culture of the European Union and what the conflict in Libya, 2011, tells us about the emergence of such a strategic culture and the EU’s capacity as an actor in security policy. It argues...... that the divergence in national strategic cultures within the EU remains a major obstacle for the EU’s ambitions to take more responsibility in the realm of security policy, and that the scope for future EU action in the hard security field is even narrower than previously imagined. The conflict in Libya showed just...

  12. System of strategic planning of enterprises activity

    OpenAIRE

    Тригоб’юк, Сергій Сергійович

    2012-01-01

    The review of researches of strategic management is resulted in the article, especially features of strategic administrative decisions, strategic diagnostics, in the system of the strategic planning of activity of enterprises, and the problems of leadership, development of strategic thinking and social aspects of business conduct in a modern variable environment also.

  13. 7 CFR 25.202 - Strategic plan.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Strategic plan. 25.202 Section 25.202 Agriculture... Procedure § 25.202 Strategic plan. (a) Principles of strategic plan. The strategic plan included in the application must be developed in accordance with the following four key principles: (1) Strategic vision...

  14. Toward a Model of Strategic Influence, International Broadcasting, and Global Engagement

    OpenAIRE

    Hacker, Kenneth L.; Vanessa R. Mendez

    2016-01-01

    This article explores how strategic communication, public diplomacy, international governmental broadcasting, and social media networking can be brought together in a system of strategic influence and global engagement. The analysis offers a contrasting approach to various views of public diplomacy or strategic communication which privilege one form of governmental influence over others and treat partial aspects of national persuasion as complete pictures of government communication aimed at ...

  15. Operationalizing strategic marketing.

    Science.gov (United States)

    Chambers, S B

    1989-05-01

    The strategic marketing process, like any administrative practice, is far simpler to conceptualize than operationalize within an organization. It is for this reason that this chapter focused on providing practical techniques and strategies for implementing the strategic marketing process. First and foremost, the marketing effort needs to be marketed to the various publics of the organization. This chapter advocated the need to organize the marketing analysis into organizational, competitive, and market phases, and it provided examples of possible designs of the phases. The importance and techniques for exhausting secondary data sources and conducting efficient primary data collection methods were explained and illustrated. Strategies for determining marketing opportunities and threats, as well as segmenting markets, were detailed. The chapter provided techniques for developing marketing strategies, including considering the five patterns of coverage available; determining competitor's position and the marketing mix; examining the stage of the product life cycle; and employing a consumer decision model. The importance of developing explicit objectives, goals, and detailed action plans was emphasized. Finally, helpful hints for operationalizing the communication variable and evaluating marketing programs were provided.

  16. Mechanisms of virus resistance and antiviral activity of snake venoms

    Directory of Open Access Journals (Sweden)

    JVR Rivero

    2011-01-01

    Full Text Available Viruses depend on cell metabolism for their own propagation. The need to foster an intimate relationship with the host has resulted in the development of various strategies designed to help virus escape from the defense mechanisms present in the host. Over millions of years, the unremitting battle between pathogens and their hosts has led to changes in evolution of the immune system. Snake venoms are biological resources that have antiviral activity, hence substances of significant pharmacological value. The biodiversity in Brazil with respect to snakes is one of the richest on the planet; nevertheless, studies on the antiviral activity of venom from Brazilian snakes are scarce. The antiviral properties of snake venom appear as new promising therapeutic alternative against the defense mechanisms developed by viruses. In the current study, scientific papers published in recent years on the antiviral activity of venom from various species of snakes were reviewed. The objective of this review is to discuss the mechanisms of resistance developed by viruses and the components of snake venoms that present antiviral activity, particularly, enzymes, amino acids, peptides and proteins.

  17. Screening for Antiviral Activities of Isolated Compounds from Essential Oils

    Directory of Open Access Journals (Sweden)

    Akram Astani

    2011-01-01

    Full Text Available Essential oil of star anise as well as phenylpropanoids and sesquiterpenes, for example, trans-anethole, eugenol, β-eudesmol, farnesol, β-caryophyllene and β-caryophyllene oxide, which are present in many essential oils, were examined for their antiviral activity against herpes simplex virus type 1 (HSV-1 in vitro. Antiviral activity was analyzed by plaque reduction assays and mode of antiviral action was determined by addition of the drugs to uninfected cells, to the virus prior to infection or to herpesvirus-infected cells. Star anise oil reduced viral infectivity by >99%, phenylpropanoids inhibited HSV infectivity by about 60–80% and sesquiterpenes suppressed herpes virus infection by 40–98%. Both, star anise essential oil and all isolated compounds exhibited anti-HSV-1 activity by direct inactivation of free virus particles in viral suspension assays. All tested drugs interacted in a dose-dependent manner with herpesvirus particles, thereby inactivating viral infectivity. Star anise oil, rich in trans-anethole, revealed a high selectivity index of 160 against HSV, whereas among the isolated compounds only β-caryophyllene displayed a high selectivity index of 140. The presence of β-caryophyllene in many essential oils might contribute strongly to their antiviral ability. These results indicate that phenylpropanoids and sesquiterpenes present in essential oils contribute to their antiviral activity against HSV.

  18. Bioprospecting of Red Sea Sponges for Novel Antiviral Pharmacophores

    KAUST Repository

    O'Rourke, Aubrie

    2015-05-01

    Natural products offer many possibilities for the treatment of disease. More than 70% of the Earth’s surface is ocean, and recent exploration and access has allowed for new additions to this catalog of natural treasures. The Central Red Sea off the coast of Saudi Arabia serves as a newly accessible location, which provides the opportunity to bioprospect marine sponges with the purpose of identifying novel antiviral scaffolds. Antivirals are underrepresented in present day clinical trials, as well as in the academic screens of marine natural product libraries. Here a high-throughput pipeline was initiated by prefacing the antiviral screen with an Image-based High-Content Screening (HCS) technique in order to identify candidates with antiviral potential. Prospective candidates were tested in a biochemical or cell-based assay for the ability to inhibit the NS3 protease of the West Nile Virus (WNV NS protease) as well as replication and reverse transcription of the Human Immunodeficiency Virus 1 (HIV-1). The analytical chemistry techniques of High-Performance Liquid Chromatograpy (HPLC), Liquid Chromatography-Mass Spectrometry (LC-MS), and Nuclear Magnetic Resonance (NMR) where used in order to identify the compounds responsible for the characteristic antiviral activity of the selected sponge fractions. We have identified a 3-alkyl pyridinium from Amphimedon chloros as the causative agent of the observed WNV NS3 protease inhibition in vitro. Additionally, we identified debromohymenialdisine, hymenialdisine, and oroidin from Stylissa carteri as prospective scaffolds capable of HIV-1 inhibition.

  19. Antiviral responses of arthropod vectors: an update on recent advances.

    Science.gov (United States)

    Rückert, Claudia; Bell-Sakyi, Lesley; Fazakerley, John K; Fragkoudis, Rennos

    2014-01-01

    Arthropod vectors, such as mosquitoes, ticks, biting midges and sand flies, transmit many viruses that can cause outbreaks of disease in humans and animals around the world. Arthropod vector species are invading new areas due to globalisation and environmental changes, and contact between exotic animal species, humans and arthropod vectors is increasing, bringing with it the regular emergence of new arboviruses. For future strategies to control arbovirus transmission, it is important to improve our understanding of virus-vector interactions. In the last decade knowledge of arthropod antiviral immunity has increased rapidly. RNAi has been proposed as the most important antiviral response in mosquitoes and it is likely to be the most important antiviral response in all arthropods. However, other newly-discovered antiviral strategies such as melanisation and the link between RNAi and the JAK/STAT pathway via the cytokine Vago have been characterised in the last few years. This review aims to summarise the most important and most recent advances made in arthropod antiviral immunity. PMID:25674592

  20. Antiviral Screening of Multiple Compounds against Ebola Virus

    Directory of Open Access Journals (Sweden)

    Stuart D. Dowall

    2016-10-01

    Full Text Available In light of the recent outbreak of Ebola virus (EBOV disease in West Africa, there have been renewed efforts to search for effective antiviral countermeasures. A range of compounds currently available with broad antimicrobial activity have been tested for activity against EBOV. Using live EBOV, eighteen candidate compounds were screened for antiviral activity in vitro. The compounds were selected on a rational basis because their mechanisms of action suggested that they had the potential to disrupt EBOV entry, replication or exit from cells or because they had displayed some antiviral activity against EBOV in previous tests. Nine compounds caused no reduction in viral replication despite cells remaining healthy, so they were excluded from further analysis (zidovudine; didanosine; stavudine; abacavir sulphate; entecavir; JB1a; Aimspro; celgosivir; and castanospermine. A second screen of the remaining compounds and the feasibility of appropriateness for in vivo testing removed six further compounds (ouabain; omeprazole; esomeprazole; Gleevec; D-LANA-14; and Tasigna. The three most promising compounds (17-DMAG; BGB324; and NCK-8 were further screened for in vivo activity in the guinea pig model of EBOV disease. Two of the compounds, BGB324 and NCK-8, showed some effect against lethal infection in vivo at the concentrations tested, which warrants further investigation. Further, these data add to the body of knowledge on the antiviral activities of multiple compounds against EBOV and indicate that the scientific community should invest more effort into the development of novel and specific antiviral compounds to treat Ebola virus disease.

  1. Antiviral responses of arthropod vectors: an update on recent advances.

    Science.gov (United States)

    Rückert, Claudia; Bell-Sakyi, Lesley; Fazakerley, John K; Fragkoudis, Rennos

    2014-01-01

    Arthropod vectors, such as mosquitoes, ticks, biting midges and sand flies, transmit many viruses that can cause outbreaks of disease in humans and animals around the world. Arthropod vector species are invading new areas due to globalisation and environmental changes, and contact between exotic animal species, humans and arthropod vectors is increasing, bringing with it the regular emergence of new arboviruses. For future strategies to control arbovirus transmission, it is important to improve our understanding of virus-vector interactions. In the last decade knowledge of arthropod antiviral immunity has increased rapidly. RNAi has been proposed as the most important antiviral response in mosquitoes and it is likely to be the most important antiviral response in all arthropods. However, other newly-discovered antiviral strategies such as melanisation and the link between RNAi and the JAK/STAT pathway via the cytokine Vago have been characterised in the last few years. This review aims to summarise the most important and most recent advances made in arthropod antiviral immunity.

  2. 总体国家安全观下美国战略情报思想对我国反恐战略的启示%Implications to Anti-terrorist in China from the Strategic Intelligence in the U.S. under the Overall National Security Concept

    Institute of Scientific and Technical Information of China (English)

    鞠心昊

    2016-01-01

    美国战略情报思想源于20世纪40年代,其中影响最大的是谢尔曼·肯特出版的专著《服务于美国世界政策的战略情报》。如今战略早已超出了传统军事战略的层面,战略定义的扩大使情报的定义摆脱了狭隘的军事情报观念。针对我国目前的反恐工作形势,该文从影响我国反恐战略制定的因素、总体国家安全观下对反恐战略提出的新要求等方面,论述了美国战略情报思想对我国反恐战略的启示,以期能为我国目前的反恐工作带来一些裨益。%The strategic intelligence in the U.S. originates in 1940s. Strategic Intelligence for American World Policy by Sherman Kent yields the most influential effect. Today the strategy has already exceeded the level of the traditional military strategy to expand the definition of strategic intelligence to make out of the narrow definition of the concept of military intelligence. In view of the current situation in the fight against terrorism, from the factors that influence the development of our counter-terrorism strategy and the new requirements for counter-terrorism strategy under the overall concept of the national security, this paper summarizes the enlightenment to China’s anti-terrorism strategy from the U.S. Strategic Intelligence.

  3. Tax rates as strategic substitutes

    NARCIS (Netherlands)

    H. Vrijburg (Hendrik); R.A. de Mooij (Ruud)

    2016-01-01

    textabstractThis paper analytically derives conditions under which the slope of the tax-reaction function is negative in a classical tax competition model. If countries maximize welfare, a negative slope (reflecting strategic substitutability) occurs under relatively mild conditions. The strategic t

  4. Strategic planning for the board.

    Science.gov (United States)

    Davies, A

    1991-04-01

    Although the planning operation is regarded by some observers as unrealistic in conditions of rapid change and increasing competition, the discipline of strategic thinking and the need for strategic leadership continue to be of vital importance. The author examines the purpose of the Board of Directors and its role in the management of strategy. PMID:10111271

  5. Transfers, Contracts and Strategic Games

    NARCIS (Netherlands)

    Kleppe, J.; Hendrickx, R.L.P.; Borm, P.E.M.; Garcia-Jurado, I.; Fiestras-Janeiro, G.

    2007-01-01

    This paper analyses the role of transfer payments and strategic con- tracting within two-person strategic form games with monetary pay- offs. First, it introduces the notion of transfer equilibrium as a strat- egy combination for which individual stability can be supported by allowing the possibilit

  6. Strategic Planning for Higher Education.

    Science.gov (United States)

    Kotler, Philip; Murphy, Patrick E.

    1981-01-01

    The framework necessary for achieving a strategic planning posture in higher education is outlined. The most important benefit of strategic planning for higher education decision makers is that it forces them to undertake a more market-oriented and systematic approach to long- range planning. (Author/MLW)

  7. Strategic Partnerships in International Development

    Science.gov (United States)

    Treat, Tod; Hartenstine, Mary Beth

    2013-01-01

    This chapter provides a framework and recommendations for development of strategic partnerships in a variety of cultural contexts. Additionally, this study elucidates barriers and possibilities in interagency collaborations. Without careful consideration regarding strategic partnerships' approaches, functions, and goals, the ability to…

  8. Strategic Planning Is an Oxymoron

    Science.gov (United States)

    Bassett, Patrick F.

    2012-01-01

    The thinking on "strategic thinking" has evolved significantly over the years. In the previous century, the independent school strategy was to focus on long-range planning, blithely projecting 10 years into the future. For decades this worked well enough, but in the late 20th century, independent schools shifted to "strategic planning," with its…

  9. Strategic Interactions in Franchise Relationships

    NARCIS (Netherlands)

    Croonen, Evelien Petronella Maria

    2006-01-01

    This dissertation deals with understanding strategic interactions between franchisors and franchisees. The empirical part of this study consists of in-depth case studies in four franchise systems in the Dutch drugstore industry. The case studies focus on a total of eight strategic change processes i

  10. Phytochemistry, cytotoxicity and antiviral activity of Eleusine indica (sambau)

    Science.gov (United States)

    Iberahim, Rashidah; Yaacob, Wan Ahmad; Ibrahim, Nazlina

    2015-09-01

    Goose grass also known as Eleusine indica (EI) is a local medicinal plant that displays antioxidant, antimicrobial and anticancer activities. The present study is to determine the phytochemical constituents, cytotoxicity and antiviral activities for both crude extract and fraction obtained from the plant. The crude extract contained more secondary metabolites compared to the hexane fraction as gauged using standard phytochemical tests. Cytotoxicity screening against Vero cells using MTT assay showed that the CC50 values for crude extract and hexane fraction were 2.07 and 5.62 mg/ml respectively. The antiviral activity towards Herpes Simplex Virus type 1 (HSV-1) was determined using plaque reduction assay. The selective indices (SI = CC50 / EC50) for both methanol extract and hexane fraction were 12.2 and 6.2 respectively. These results demonstrate that the extract prepared from E. indica possesses phytochemical compound that was non cytotoxic to the cell with potential antiviral activity.

  11. The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro

    Directory of Open Access Journals (Sweden)

    Xiang Li

    2015-08-01

    Full Text Available Baicalin is a flavonoid compound extracted from Scutellaria roots that has been reported to possess antibacterial, anti-inflammatory, and antiviral activities. However, the antiviral effect of baicalin on enterovirus 71 (EV71 is still unknown. In this study, we found that baicalin showed inhibitory activity on EV71 infection and was independent of direct virucidal or prophylactic effect and inhibitory viral absorption. The expressions of EV71/3D mRNA and polymerase were significantly blocked by baicalin treatment at early stages of EV71 infection. In addition, baicalin could decrease the expressions of FasL and caspase-3, as well as inhibit the apoptosis of EV71-infected human embryonal rhabdomyosarcoma (RD cells. Altogether, these results indicate that baicalin exhibits potent antiviral effect on EV71 infection, probably through inhibiting EV71/3D polymerase expression and Fas/FasL signaling pathways.

  12. Antiviral defense in shrimp: from innate immunity to viral infection.

    Science.gov (United States)

    Wang, Pei-Hui; Huang, Tianzhi; Zhang, Xiaobo; He, Jian-Guo

    2014-08-01

    The culture of penaeid shrimp is rapidly developing as a major business endeavor worldwide. However, viral diseases have caused huge economic loss in penaeid shrimp culture industries. Knowledge of shrimp innate immunity and antiviral responses has made important progress in recent years, allowing the design of better strategies for the prevention and control of shrimp diseases. In this study, we have updated information on shrimp antiviral immunity and interactions between shrimp hosts and viral pathogens. Current knowledge and recent progress in immune signaling pathways (e.g., Toll/IMD-NF-κB and JAK-STAT signaling pathways), RNAi, phagocytosis, and apoptosis in shrimp antiviral immunity are discussed. The mechanism of viral infection in shrimp hosts and the interactions between viruses and shrimp innate immune systems are also analyzed.

  13. IS and Business Leaders' Strategizing

    DEFF Research Database (Denmark)

    Hansen, Anne Mette

    business environments characterized by changes in market demands, technology options, and government regulations. Under such dynamic conditions, IS and business leaders must constantly strategize and set new IS strategic objectives so that they can retain and improve innovation, competitiveness......, and productivity. However, strategizing in such dynamic environments is not straightforward process. While IS and business leaders must develop new IS strategic objectives and move quickly towards new opportunities, they must also be good at exploiting the value of current assets and reducing the costs of existing...... operations. Drawing upon organizational learning theory (March 1991), this process involves two learning processes: exploration and exploitation. Leaders explore new strategic initiatives in response to environmental shifts while at the same time effectively exploiting what they have already learned from...

  14. Strategic groups in the Belgian fishing fleet

    OpenAIRE

    Stouten, H.; A. HEENE; Gellynck, X.; Polet, H

    2011-01-01

    This study examines the heterogeneity of the Belgian fishing fleet based on “strategic groups”, a concept borrowed from the field of strategic management. Its objectives are: (1) to define strategic groups within the Belgian fishing fleet; (2) to examine the performance differences among these strategic groups; (3) to examine whether firms (i.e., vessels) move between strategic groups over time; and (4) to examine if firm-movement (i.e., vessel-movement) differs across strategic groups. In th...

  15. ICT Strategic Planning for Mazandaran Province

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Shojaie

    2012-02-01

    Full Text Available Today, regarding rapid changes in the environment, any organization, institution or country that overlooks its capabilities, strengths and weaknesses, will face real challenges. Strategic planning in organizations is a common response to these challenges which also facilitate achieving goals in an organization. Today, the importance of ICT is increased, which necessitates ICT strategic planning to use ICT in organizations. So, this study aimed to propose ICT strategic plans for Mazandaran province. For this end, at first using stakeholders' viewpoints, the vision, mission and goals are provided. Then, Internal & External Matrix was suggested and identified factors were ranked using Analytic Network Processing (ANP. Then, concerning strengths, weaknesses, opportunities, threats, and using SWOT analysis, ICT strategies were provided. Finally, using QSPM matrix, the strategies were ranked. Regarding this ranking, dedicated budget to ICT in governmental organizations, using integration architecture, developing organizational and inter-organizational information systems, developing mechanisms to absorb national and local financial resources for extending ICT infrastructures and finally concerning ICT trainings for managers and people, were in the top of the list.

  16. Strategic cycling: shaking complacency in healthcare strategic planning.

    Science.gov (United States)

    Begun, J; Heatwole, K B

    1999-01-01

    As the conditions affecting business and healthcare organizations in the United States have become more turbulent and uncertain, strategic planning has decreased in popularity. Strategic planning is criticized for stiffling creative responses to the new marketplace and for fostering compartmentalized organizations, adherence to outmoded strategies, tunnel vision in strategy formulation, and overemphasis on planning to the detriment of implementation. However, effective strategic planning can be a force for mobilizing all the constituents of an organization, creating discipline in pursuit of a goal, broadening an organization's perspective, improving communication among disciplines, and motivating the organization's workforce. It is worthwhile for healthcare organizations to preserve these benefits of strategic planning at the same time recognizing the many sources of turbulence and uncertainty in the healthcare environment. A model of "strategic cycling" is presented to address the perceived shortcomings of traditional strategic planning in a dynamic environment. The cycling model facilitates continuous assessment of the organization's mission/values/vision and primary strategies based on feedback from benchmark analysis, shareholder impact, and progress in strategy implementation. Multiple scenarios and contingency plans are developed in recognition of the uncertain future. The model represents a compromise between abandoning strategic planning and the traditional, linear model of planning based on progress through predetermined stages to a masterpiece plan. PMID:10621138

  17. Capabilities for Strategic Adaptation

    DEFF Research Database (Denmark)

    Distel, Andreas Philipp

    firms’ ability to absorb and leverage new knowledge. The third paper is an empirical study which conceptualizes top managers’ resource cognition as a managerial capability underlying firms’ resource adaptation; it empirically examines the performance implications of this capability and organizational......This dissertation explores capabilities that enable firms to strategically adapt to environmental changes and preserve competitiveness over time – often referred to as dynamic capabilities. While dynamic capabilities being a popular research domain, too little is known about what these capabilities...... empirical studies through the dynamic capabilities lens and develops propositions for future research. The second paper is an empirical study on the origins of firm-level absorptive capacity; it explores how organization-level antecedents, through their impact on individual-level antecedents, influence...

  18. U.S. Department of Energy Office of Indian Energy Policy and Programs: Strategic Roadmap 2025

    Energy Technology Data Exchange (ETDEWEB)

    2016-03-01

    The U.S. Department of Energy Office of Indian Energy Policy and Programs Strategic Roadmap 2025 outlines strategic target areas and tactical actions to ensure the Office remains aligned with its congressional mandates and DOE goals, and that it can be responsive to changing conditions in Indian Country and the nation.

  19. Is Minocycline an Antiviral Agent? A Review of Current Literature.

    Science.gov (United States)

    Nagarakanti, Sandhya; Bishburg, Eliahu

    2016-01-01

    Minocycline is a second-generation semi-synthetic derivative of tetracycline and has well-known anti-bacterial effects. The drug possesses anti-inflammatory, anti-oxidant, anti-apoptotic and immunomodulatory effects. The drug is widely used in bacterial infections and non-infectious conditions such as acne, dermatitis, periodontitis and neurodegenerative conditions. Minocycline was shown to have antiviral activity in vitro and also against different viruses in some animal models. Some studies have been done on human patients infected with Human Immunodeficiency Virus. We have review the available data regarding minocycline activity as an antiviral agent. PMID:26177421

  20. Antiviral, antifungal and antiprotozoal agents in the cinema.

    Science.gov (United States)

    García-Sánchez, Jose Elias; García-Sánchez, E; Merino Marcos, M L

    2007-03-01

    Among the antimicrobial agents, antibacterials are the most frequently mentioned in cinematographic plots. Nevertheless, it is not uncommon to come across other antiviral agents, especially antiretrovirals and antiprotozoals. We analyzed the presence of antiviral and antifungal agents in different commercial films, both when they were merely mentioned in passing and when they played a major role in the film. This review essentially aims to address the historical portrayal of these agents in film and to list their appearances. The fictional treatments that appear in some films are not addressed.

  1. ABSTRACTS Preliminary Study of Strategic Inner Cores

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    When a strategic entity attempts to make a dicision, first the project must be m accoroance wlm its strategic framework as well as make the strategic inner cores prominent. The existing theories of development strategy indicate that the formation of the framework can be divided into the following parts: inside and outside environments, purpose, goal, key points, and countermeasures. The strategic inner cores that put forward by this paper is the intensification and advancement for the theory of strategic framework, strategic orientation, strategic vision and main line are inciuded. Appearance of these ideas have improved the theory and enhanced strategic practice.

  2. Strategic Cost Management

    Institute of Scientific and Technical Information of China (English)

    陆春玲

    1999-01-01

    本文作者管理学教授Robin Cooper和管理会计学教授Regine Slagmulder认为:一个公司全局性的战略成本管理通常包括两个模式。模式之一着重于业务改进,旨在提高公司的效率;模式之二则着重于战略成本,旨在帮助公司明确可获得利润的来源。这两种模式所需要的成本信息是截然不同的。遗憾的是许多公司都企图仅用其中的一种模式去实现两种模式协调方能实现的功能。这种单一的模式体系必然会导致公司运行效率低下。 本文的结构非常清楚。两位教授在分别论述了两种模式的不同后着重指出它们有相同的基本目标,应该相互连贯,两者连结的critial point is that the operational improvement module should be the primary source of much of the information used by the strategic costing module.而在保持两者关系的数种方法中,a particularly effective one is to use two sets of standards: the "updated" and the "strategic".】

  3. Aktivitas Antiviral Minyak Atsiri Jahe Merah terhadap Virus Flu Burung (ANTIVIRAL ACTIVITY OF ESSENSIAL OIL RED GINGER ON AVIAN INFLUENZA

    Directory of Open Access Journals (Sweden)

    Tri Untari

    2013-07-01

    Full Text Available The studies have reported that ginger have many activities such as antiemesis, anti-inflammatory,anti-bacterial and anti-parasites. Therefore, this study was conducted to evaluate antiviral effect of essentialred ginger oil againts Avian Influenza (AI in ovo using hemagglutination test (HA. Avian Influenzaviruses were treated with 0,01%, 0,1% and 1% of essential red ginger oil, and then inoculated in chickenembryonated egg via allantoic sac. Allantoic fluid was harvested using for HA test . Result of this studyshows that application of 1% of essential red ginger oil results in the reduction of titer HA . Interestingly,essential oil shows antiviral activity revealed HA titre 20 whereas the titre HA AI which AI virus treatedwith 0,01% and 0,1% essential red ginger oil, the HA titer was 25. The conclution of this study proved thatessensial oil 1% of the red gingger is the best concentration as antiviral activity .

  4. Micro Sourcing Strategic Framework for Low Income Group

    Directory of Open Access Journals (Sweden)

    Noor Habibah Arshad

    2013-07-01

    Full Text Available The role of ICTs among poor people and communities has increased tremendously. One of the ICT industries – the micro sourcing industry – has been identified as one of a potential industry to help increase income for the poor in Malaysia. Micro sourcing is an effective way to accomplish tedious tasks at a faster rate. It involves large projects that are broken down into micro tasks. These micro tasks are well-defined and then distributed to a group of workers. The objective of this study is to develop the strategic framework of micro sourcing to generate income for the low income group. Four methods were used to gather information for this study. The methods used were documentation and literature reviews, focus group meetings, workshops and interviews. Based on the analysis of the current scenario of local micro sourcing industry, strategic framework was developed based on the five Strategic Thrusts identified. The Strategic Thrusts are harnessing demand side (job providers of domestic and international market; platform capacity and capability building; leverage and utilise existing infrastructure; uplift and enhance capability of the supply side (micro workers; and instruments to expedite growth of local micro sourcing industry. The Strategic Framework is intended to provide strategic direction at national level to all stakeholders; to highlight key areas that need to be addressed in order to grow a sustainable micro sourcing industry in the country; and to serve as a guideline in the implementation of programs and plans related to micro sourcing industry development

  5. Management of strategic coopetition among partners within international airline alliances

    Directory of Open Access Journals (Sweden)

    Frank Himpel

    2012-03-01

    Full Text Available Background: International network-carriers span the globe by linking airports on all five continents. At the core of those networks are hub-airports that serve as the centers for (inter-national in- and outbound traffic flows. From a business model point of view, the major international carriers are so-called network-carriers, for their core concept is based on transfer-oriented hub-and-spoke-systems. In order to maximize revenue streams of network-carriers, changes in strategic slot allocation and strategic net planning are becoming increasingly relevant. The aim of this work was to analyze the impact of various elements of the management of strategic coopetition among partners within international airline alliances on the revenues obtained by individual partners. Methods: the problems related to the optimization of strategic slot allocation and strategic net planning from the point of view of the individual profit shared and added net contribution margins were discussed. Results and conclusions: Two extreme scenarios may be projected. The first one is that partners within a given alliance system may start to increase merger and acquisition activities. Thereby scale effects may be utilized. The other one is, when rivalry becomes too dominant over time, some partners may (have to exit alliance systems. Thereby "atomic" subsystems may be on the rebound. Strategic coopetition management is aimed to keep leading international network carriers "on track" in the field of alliance management of that nature.

  6. DMPD: The interferon in TLR signaling: more than just antiviral. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 14552837 The interferon in TLR signaling: more than just antiviral. Hertzog PJ, O'N...on in TLR signaling: more than just antiviral. PubmedID 14552837 Title The interferon in TLR signaling: more than just anti

  7. Complex Strategic Choices Applying Systemic Planning for Strategic Decision Making

    CERN Document Server

    Leleur, Steen

    2012-01-01

    Effective decision making requires a clear methodology, particularly in a complex world of globalisation. Institutions and companies in all disciplines and sectors are faced with increasingly multi-faceted areas of uncertainty which cannot always be effectively handled by traditional strategies. Complex Strategic Choices provides clear principles and methods which can guide and support strategic decision making to face the many current challenges. By considering ways in which planning practices can be renewed and exploring the possibilities for acquiring awareness and tools to add value to strategic decision making, Complex Strategic Choices presents a methodology which is further illustrated by a number of case studies and example applications. Dr. Techn. Steen Leleur has adapted previously established research based on feedback and input from various conferences, journals and students resulting in new material stemming from and focusing on practical application of a systemic approach. The outcome is a coher...

  8. 1997 U.S. Department of Energy Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    None,

    1997-09-01

    With the end of the Cold War and the election of President Clinton, the Department of Energy (DOE) set a new course which began with the publication of its first departmental strategic plan in April 1994. Entitled ``Fueling a Competitive Economy, it provided the framework and shared vision for meeting responsibilities in energy, national security, environmental quality, and science and technology. The strategic plan was the guidepost for the formulation of the Department`s FY 1996, FY 1997, and FY 1998 budgets and was critical to the development of the Department`s Strategic Alignment Initiative, designed to save $1.7 billion over five years. This current plan, which has been significantly improved through a very close consultation process with Congress and customers stakeholders, takes DOE to the next important performance level by being more directly linked to actions and results. It defines a strategic goal for each of the Department`s four business lines and, in the spirit of the Government Performance and Results Act and the National Performance Review, identifies a fifth goal addressing corporate management. Reengineering the business practices, managing for results, being open with neighbors and stakeholders, and ensuring the safety and health of DOE workers and the public are, and will continue to be, among the highest of priorities. Over the coming years, DOE plans to achieve their strategic goals through specific identifiable strategies. Each business line has clear objectives and straightforward ways of defining whether DOE has succeeded in meeting those objectives.

  9. Networks and meshworks in strategizing

    DEFF Research Database (Denmark)

    Esbjerg, Lars; Andersen, Poul Houman

    The purpose of this paper is to examine the business network metaphor in relation to strategizing in business and to tentatively propose an alternative metaphor, that of the business meshwork. The paper reviews existing work on strategy and strategizing within the IMP literature, particularly...... the literature on networks and network pictures, and identifies several shortcomings of this work. To develop the notion of business meshworks as an alternative for understanding strategizing practices in business interaction, the paper draws on recent writings within anthropology and the strategy......-as-practice literature....

  10. 2016-2020 Strategic Plan and Implementing Framework

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-11-01

    The 2016-2020 Strategic Plan and Implementing Framework from the Office of Energy Efficiency and Renewable Energy (EERE) is the blueprint for launching the nation’s leadership in the global clean energy economy. This document will guide the organization to build on decades of progress in powering our nation from clean, affordable and secure energy.

  11. Strategic management of research and development: A literature search

    Science.gov (United States)

    Sterkin, Carol K. (Compiler)

    1988-01-01

    Each abstract was reviewed as to its described contents and potential applicability to the topics expected to be addressed at the 1988 National Conference on strategic management of research and development. In each section the citations are listed alphabetically by senior or corporate author. The names, addresses, and telephone numbers of organizations from which the listed material may be requested, are provided.

  12. Cloud computing strategic framework (FY13 - FY15).

    Energy Technology Data Exchange (ETDEWEB)

    Arellano, Lawrence R.; Arroyo, Steven C.; Giese, Gerald J.; Cox, Philip M.; Rogers, G. Kelly

    2012-11-01

    This document presents an architectural framework (plan) and roadmap for the implementation of a robust Cloud Computing capability at Sandia National Laboratories. It is intended to be a living document and serve as the basis for detailed implementation plans, project proposals and strategic investment requests.

  13. DMPD: An arms race: innate antiviral responses and counteracting viral strategies. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18031256 An arms race: innate antiviral responses and counteracting viral strategies...arms race: innate antiviral responses and counteracting viral strategies. PubmedID 18031256 Title An arms ra...ce: innate antiviral responses and counteracting viral strategies. Authors Schrod

  14. DMPD: Negative regulation of cytoplasmic RNA-mediated antiviral signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18703349 Negative regulation of cytoplasmic RNA-mediated antiviral signaling. Komur...Show Negative regulation of cytoplasmic RNA-mediated antiviral signaling. PubmedID 18703349 Title Negative r...egulation of cytoplasmic RNA-mediated antiviral signaling. Authors Komuro A, Bamm

  15. DMPD: Triggering the innate antiviral response through IRF-3 activation. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17395583 Triggering the innate antiviral response through IRF-3 activation. Hiscott...g the innate antiviral response through IRF-3 activation. PubmedID 17395583 Title Triggering the innate anti...viral response through IRF-3 activation. Authors Hiscott J. Publication J Biol Ch

  16. DMPD: What is disrupting IFN-alpha's antiviral activity? [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15283983 What is disrupting IFN-alpha's antiviral activity? Mbow ML, Sarisky RT. Tr...ends Biotechnol. 2004 Aug;22(8):395-9. (.png) (.svg) (.html) (.csml) Show What is disrupting IFN-alpha's antiviral activity...? PubmedID 15283983 Title What is disrupting IFN-alpha's antiviral activity? Authors Mbow ML,

  17. DMPD: Regulation of mitochondrial antiviral signaling pathways. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18549796 Regulation of mitochondrial antiviral signaling pathways. Moore CB, Ting J...P. Immunity. 2008 Jun;28(6):735-9. (.png) (.svg) (.html) (.csml) Show Regulation of mitochondrial antiviral signaling path...ways. PubmedID 18549796 Title Regulation of mitochondrial antiviral signaling pathways. Author

  18. DMPD: TLR3 in antiviral immunity: key player or bystander? [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 16027039 TLR3 in antiviral immunity: key player or bystander? Schroder M, Bowie AG.... Trends Immunol. 2005 Sep;26(9):462-8. (.png) (.svg) (.html) (.csml) Show TLR3 in antiviral immunity: key pl...ayer or bystander? PubmedID 16027039 Title TLR3 in antiviral immunity: key player or bystander? Authors Schr

  19. Global Market. Global Strategic Rflection?A Strategic Apprroach Methodology..

    OpenAIRE

    Vivas, Carla; Sousa, António

    2011-01-01

    This paper aims to analyze the competitive environment of international companies in the wine sector and assess the implications in terms of development of strategic guidelines and quotas various performances. We propose the application of the methodological Integrated Grid of Strategic Reflection (IGSR), based on a literature from the literature (business management and viticulture), primary data collection and creative reflection. For qualitative analysis we used the PEST method and five fo...

  20. Evaluation of antiseptic antiviral activity of chemical agents.

    Science.gov (United States)

    Geller, Chloé; Finance, Chantal; Duval, Raphaël Emmanuel

    2011-06-01

    Antiviral antisepsis and disinfection are crucial for preventing the environmental spread of viral infections. Emerging viruses and associated diseases, as well as nosocomial viral infections, have become a real issue in medical fields, and there are very few efficient and specific treatments available to fight most of these infections. Another issue is the potential environmental resistance and spread of viral particles. Therefore, it is essential to properly evaluate the efficacy of antiseptics-disinfectants (ATS-D) on viruses. ATS-D antiviral activity is evaluated by (1) combining viruses and test product for an appropriately defined and precise contact time, (2) neutralizing product activity, and (3) estimating the loss of viral infectivity. A germicide can be considered to have an efficient ATS-D antiviral activity if it induces a >3 or >4 log(10) reduction (American and European regulatory agency requirements, respectively) in viral titers in a defined contact time. This unit describes a global methodology for evaluating chemical ATS-D antiviral activity.

  1. INVESTMENT IN ANTIVIRAL DRUGS : A REAL OPTIONS APPROACH

    NARCIS (Netherlands)

    Attema, Arthur E.; Lugner, Anna K.; Feenstra, Talitha L.

    2010-01-01

    Real options analysis is a promising approach to model investment under uncertainty. We employ this approach to value stockpiling of antiviral drugs as a precautionary measure against a possible influenza pandemic. Modifications of the real options approach to include risk attitude and deviations fr

  2. Small molecules with antiviral activity against the Ebola virus.

    Science.gov (United States)

    Litterman, Nadia; Lipinski, Christopher; Ekins, Sean

    2015-01-01

    The recent outbreak of the Ebola virus in West Africa has highlighted the clear shortage of broad-spectrum antiviral drugs for emerging viruses. There are numerous FDA approved drugs and other small molecules described in the literature that could be further evaluated for their potential as antiviral compounds. These molecules are in addition to the few new antivirals that have been tested in Ebola patients but were not originally developed against the Ebola virus, and may play an important role as we await an effective vaccine. The balance between using FDA approved drugs versus novel antivirals with minimal safety and no efficacy data in humans should be considered. We have evaluated 55 molecules from the perspective of an experienced medicinal chemist as well as using simple molecular properties and have highlighted 16 compounds that have desirable qualities as well as those that may be less desirable. In addition we propose that a collaborative database for sharing such published and novel information on small molecules is needed for the research community studying the Ebola virus. PMID:25713700

  3. Adenovirus infection reverses the antiviral state induced by human interferon.

    Science.gov (United States)

    Feduchi, E; Carrasco, L

    1987-04-01

    HeLa cells treated with human lymphoblastoid interferon do not synthesize poliovirus proteins. The antiviral state against poliovirus is reversed if cells are previously infected with adenovirus type 5. A late gene product seems to be involved in this reversion, since no effect is observed at early stages of infection or in the presence of aphidicolin.

  4. Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin.

    Science.gov (United States)

    Croci, Romina; Bottaro, Elisabetta; Chan, Kitti Wing Ki; Watanabe, Satoru; Pezzullo, Margherita; Mastrangelo, Eloise; Nastruzzi, Claudio

    2016-01-01

    RNA virus infections can lead to the onset of severe diseases such as fever with haemorrhage, multiorgan failure, and mortality. The emergence and reemergence of RNA viruses continue to pose a significant public health threat worldwide with particular attention to the increasing incidence of flaviviruses, among others Dengue, West Nile Virus, and Yellow Fever viruses. Development of new and potent antivirals is thus urgently needed. Ivermectin, an already known antihelminthic drug, has shown potent effects in vitro on Flavivirus helicase, with EC50 values in the subnanomolar range for Yellow Fever and submicromolar EC50 for Dengue Fever, Japanese encephalitis, and tick-borne encephalitis viruses. However ivermectin is hampered in its application by pharmacokinetic problems (little solubility and high cytotoxicity). To overcome such problems we engineered different compositions of liposomes as ivermectin carriers characterizing and testing them on several cell lines for cytotoxicity. The engineered liposomes were less cytotoxic than ivermectin alone and they showed a significant increase of the antiviral activity in all the Dengue stains tested (1, 2, and S221). In the current study ivermectin is confirmed to be an effective potential antiviral and liposomes, as drug carriers, are shown to modulate the drug activity. All together the results represent a promising starting point for future improvement of ivermectin as antiviral and its delivery. PMID:27242902

  5. Antiviral medication in sexually transmitted diseases. Part I: HSV, HPV.

    Science.gov (United States)

    Mlynarczyk-Bonikowska, Beata; Majewska, Anna; Malejczyk, Magdalena; Mlynarczyk, Grazyna; Majewski, Slawomir

    2013-11-01

    Sexually transmitted diseases (STD) are one of the most prevalent infectious diseases in the world and important cause of morbidity and mortality. Especially STDs of viral etiology are difficult to cure. In many cases the antiviral therapy can relieve the symptoms but not eliminate the virus. During the past decades, considerable progress has been made in the development of antiviral drugs. One of the oldest antiviral medications is acyclovir (ACV). It is approved to treat initial and recurrent genital herpes and as a suppressive therapy in severe recurrent genital infections as well. Drug resistance to ACV and related drugs is seen among immunocompromised hosts, including human immunodeficiency virus HIV-infected patients. Resistant infections can be managed by second-line drugs - foscarnet or cidofovir- but they are more toxic than ACV. In case of HPV there is not known specific target for the medication and that is why the substances used in human papilloma virus HPV infection therapy are either antimitotics or immunomodulators. The Part I review focuses on mechanisms of actions and mechanisms of resistance to antiviral agents used in a treatment of the genital herpes and genital HPV infection. In Part II we will show the therapeutic options in other sexually transmitted infections: hepatitis B, C and HIV. PMID:24032509

  6. Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin

    Directory of Open Access Journals (Sweden)

    Romina Croci

    2016-01-01

    Full Text Available RNA virus infections can lead to the onset of severe diseases such as fever with haemorrhage, multiorgan failure, and mortality. The emergence and reemergence of RNA viruses continue to pose a significant public health threat worldwide with particular attention to the increasing incidence of flaviviruses, among others Dengue, West Nile Virus, and Yellow Fever viruses. Development of new and potent antivirals is thus urgently needed. Ivermectin, an already known antihelminthic drug, has shown potent effects in vitro on Flavivirus helicase, with EC50 values in the subnanomolar range for Yellow Fever and submicromolar EC50 for Dengue Fever, Japanese encephalitis, and tick-borne encephalitis viruses. However ivermectin is hampered in its application by pharmacokinetic problems (little solubility and high cytotoxicity. To overcome such problems we engineered different compositions of liposomes as ivermectin carriers characterizing and testing them on several cell lines for cytotoxicity. The engineered liposomes were less cytotoxic than ivermectin alone and they showed a significant increase of the antiviral activity in all the Dengue stains tested (1, 2, and S221. In the current study ivermectin is confirmed to be an effective potential antiviral and liposomes, as drug carriers, are shown to modulate the drug activity. All together the results represent a promising starting point for future improvement of ivermectin as antiviral and its delivery.

  7. Bilirubin: an endogenous molecule with antiviral activity in vitro.

    Directory of Open Access Journals (Sweden)

    Rosaria eSantangelo

    2012-03-01

    Full Text Available Bilirubin-IX-alpha (BR is the final product of heme metabolism through the heme oxygenase/biliverdin reductase (HO/BVR system. Previous papers reported on the microbicidal effects of the HO by-products biliverdin-IX-alpha, carbon monoxide and iron, through either direct or indirect mechanisms. In this paper the evidence of a virucidal effect of BR against human herpes simplex virus type 1 (HSV-1 and the enterovirus EV71 was provided. Bilirubin-IX-alpha, at concentrations 1-10 µM, close to those found in blood and tissues, significantly reduced HSV-1 and EV71 replication in Hep-2 and Vero cell lines, respectively. Bilirubin-IX-alpha inhibited viral infection of Hep-2 and Vero cells when given 2 hours before, concomitantly and 2 hours after viral infection. Furthermore, BR retained its antiviral activity even complexed with a saturating concentration of human serum-albumin. Moreover, 10 µM BR increased the formation of nitric oxide and the phosphorylation of JNK in Vero and Hep-2 cell lines, respectively, thus implying a role of these two pathways in the mechanism of antiviral activity of the bile pigment. In conclusion, these results support the antiviral effect of BR against HSV-1 and enterovirus in vitro, and put the basis for further basic and clinical studies to understand the real role of BR as an endogenous antiviral molecule.

  8. Approved Antiviral Drugs over the Past 50 Years.

    Science.gov (United States)

    De Clercq, Erik; Li, Guangdi

    2016-07-01

    Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs categorized into 13 functional groups have been formally approved for the treatment of the following 9 human infectious diseases: (i) HIV infections (protease inhibitors, integrase inhibitors, entry inhibitors, nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and acyclic nucleoside phosphonate analogues), (ii) hepatitis B virus (HBV) infections (lamivudine, interferons, nucleoside analogues, and acyclic nucleoside phosphonate analogues), (iii) hepatitis C virus (HCV) infections (ribavirin, interferons, NS3/4A protease inhibitors, NS5A inhibitors, and NS5B polymerase inhibitors), (iv) herpesvirus infections (5-substituted 2'-deoxyuridine analogues, entry inhibitors, nucleoside analogues, pyrophosphate analogues, and acyclic guanosine analogues), (v) influenza virus infections (ribavirin, matrix 2 protein inhibitors, RNA polymerase inhibitors, and neuraminidase inhibitors), (vi) human cytomegalovirus infections (acyclic guanosine analogues, acyclic nucleoside phosphonate analogues, pyrophosphate analogues, and oligonucleotides), (vii) varicella-zoster virus infections (acyclic guanosine analogues, nucleoside analogues, 5-substituted 2'-deoxyuridine analogues, and antibodies), (viii) respiratory syncytial virus infections (ribavirin and antibodies), and (ix) external anogenital warts caused by human papillomavirus infections (imiquimod, sinecatechins, and podofilox). Here, we present for the first time a comprehensive overview of antiviral drugs approved over the past 50 years, shedding light on the development of effective antiviral treatments against current and emerging infectious diseases worldwide. PMID:27281742

  9. Antiviral effect of methylated flavonol isorhamnetin against influenza.

    Directory of Open Access Journals (Sweden)

    Ahmed Abdal Dayem

    Full Text Available Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic concern due to the costly countermeasures it necessitates. In this study, we compared the antiviral activities of several flavonols and other flavonoids with similar, but distinct, hydroxyl or methyl substitution patterns at the 3, 3', and 4' positions of the 15-carbon flavonoid skeleton, and found that the strongest antiviral effect was induced by isorhamnetin. Similar to quercetin and kaempferol, isorhamnetin possesses a hydroxyl group on the C ring, but it has a 3'-methyl group on the B ring that is absent in quercetin and kaempferol. Co-treatment and pre-treatment with isorhamnetin produced a strong antiviral effect against the influenza virus A/PR/08/34(H1N1. However, isorhamnetin showed the most potent antiviral potency when administered after viral exposure (post-treatment method in vitro. Isorhamnetin treatment reduced virus-induced ROS generation and blocked cytoplasmic lysosome acidification and the lipidation of microtubule associated protein1 light chain 3-B (LC3B. Oral administration of isorhamnetin in mice infected with the influenza A virus significantly decreased lung virus titer by 2 folds, increased the survival rate which ranged from 70-80%, and decreased body weight loss by 25%. In addition, isorhamnetin decreased the virus titer in ovo using embryonated chicken eggs. The structure-activity relationship (SAR of isorhamnetin could explain its strong anti-influenza virus potency; the methyl group located on the B ring of isorhamnetin may contribute to its strong antiviral potency against influenza virus in comparison with other flavonoids.

  10. Maintenance Process Strategic Analysis

    Science.gov (United States)

    Jasiulewicz-Kaczmarek, M.; Stachowiak, A.

    2016-08-01

    The performance and competitiveness of manufacturing companies is dependent on the availability, reliability and productivity of their production facilities. Low productivity, downtime, and poor machine performance is often linked to inadequate plant maintenance, which in turn can lead to reduced production levels, increasing costs, lost market opportunities, and lower profits. These pressures have given firms worldwide the motivation to explore and embrace proactive maintenance strategies over the traditional reactive firefighting methods. The traditional view of maintenance has shifted into one of an overall view that encompasses Overall Equipment Efficiency, Stakeholders Management and Life Cycle assessment. From practical point of view it requires changes in approach to maintenance represented by managers and changes in actions performed within maintenance area. Managers have to understand that maintenance is not only about repairs and conservations of machines and devices, but also actions striving for more efficient resources management and care for safety and health of employees. The purpose of the work is to present strategic analysis based on SWOT analysis to identify the opportunities and strengths of maintenance process, to benefit from them as much as possible, as well as to identify weaknesses and threats, so that they could be eliminated or minimized.

  11. Dominant investors and strategic transparency

    NARCIS (Netherlands)

    E.C. Perotti; E.-L. von Thadden

    1999-01-01

    This paper studies product market competition under a strategic transparency decision. Dominant investors can influence information collection in the financial market, and thereby corporate transparency, by affecting market liquidity or the cost of information collection. More transparency on a firm

  12. Dominant investors and strategic transparency

    NARCIS (Netherlands)

    E.C. Perotti; E.-L. von Thadden

    1998-01-01

    This paper studies product market competition under a strategic transparency decision. Dominant investors can influence information collection in the financial market, and thereby corporate transparency, by affecting market liquidity or the cost of information collection. More transparency on a firm

  13. The Strategic Process in Organisations

    DEFF Research Database (Denmark)

    Sørensen, Lene; Vidal, Rene Victor Valqui

    1999-01-01

    Organisational strategy development is often conceptualised through methodological frameworks. In this paper strategy development is seen as a strategic process characterised by inherent contradictions between actors, OR methods and the problem situation. The paper presents the dimensions...

  14. Energy research strategic plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    Research and development is an essential element of economic prosperity and a traditional source of strength for the U.S. economy. During the past two decades, the way of introducing technological developments into the national economy has changed steadily. Previously, industry did most long-term technology development and some basic research with private funding. Today, the Nation`s industry relies mostly on federally-funded research to provide the knowledge base that leads to new technologies and economic growth. In the 1980s, U.S. firms lost major technology markets to foreign competition. In response, many firms increased emphasis on technology development for near term payoff while decreasing long term research for new technology. The purpose of the Office of Energy Research of the U.S. Department of Energy (DOE) is to provide basic research and technology development that triggers and drives economic development and helps maintain U.S. world leadership in science. We do so through programs of basic and applied research that support the Department`s energy, environmental and national defense missions and that provide the foundation for technical advancement. We do so by emphasizing research that maintains our world leadership in science, mathematics, and engineering and through partnerships with universities, National Laboratories, and industries across the Nation.

  15. Strategic patenting and software innovation

    OpenAIRE

    Noel, Michael; Schankerman, Mark

    2013-01-01

    Strategic patenting is widely believed to raise the costs of innovating, especially in industries characterised by cumulative innovation. This paper studies the effects of strategic patenting on R&D, patenting and market value in the computer software industry. We focus on two key aspects: patent portfolio size, which affects bargaining power in patent disputes, and the fragmentation of patent rights (‘patent thickets’) which increases the transaction costs of enforcement. We develop a model ...

  16. The Economics of Strategic Opportunity

    OpenAIRE

    Denrell, Jerker; Fang, Christina; Winter, Sidney G.

    2003-01-01

    As emphasized by Barney (1986), any explanation of superior profitability must account for why the resources supporting such profitability could have been acquired for a price below their rent generating capacity. Building upon the literature in economics on coordination failures and incomplete markets, we suggest a framework for analyzing such strategic factor market inefficiencies. Our point of departure is that a strategic opportunity exists whenever prices fail to reflect the value of a r...

  17. The Emerging Strategic Entrepreneurship Field

    OpenAIRE

    Foss, Nicolai J.; Lyngsie, Jacob

    2011-01-01

    The field of strategic entrepreneurship is a fairly recent one. Its central idea is that opportunity-seeking and advantage-seeking—the former the central subject of the entrepreneurship field, the latter the central subject of the strategic management field— are processes that need to be considered jointly. The purpose of this brief chapter is to explain the emergence of SE theory field in terms of a response to research gaps in the neighboring fields of entrepreneurship and st...

  18. Executive presence for strategic influence.

    Science.gov (United States)

    Shirey, Maria R

    2013-01-01

    This department highlights change management strategies that may be successful in strategically planning and executing organizational change initiatives. With the goal of presenting practical approaches helpful to nurse leaders advancing organizational change, content includes evidence-based projects, tools, and resources that mobilize and sustain organizational change initiatives. In this article, the author discusses cultivating executive presence, a crucial component of great leadership, needed for strategic influence and to drive change.

  19. Pharmaceutical industry in strategic development

    OpenAIRE

    2013-01-01

    World pharmaceutical industry has been changing profoundly as it has been steadily concentrating and consolidating in the last decade. According to our survey, we may underline the intensive marketing management represents an extremely important operational and even strategic function for proper business performance and long-term strategic orientation for the world pharmaceutical companies. We may even conclude that intensive consolidation of world pharmaceutical industry is a market driven a...

  20. ASPECTS REGARDING SMEs’ STRATEGIC MANAGEMENT

    OpenAIRE

    MAGDALENA VORZSÁK; MONICA MARIA COROS

    2007-01-01

    The main objective of the present research is to formulate a set of pertinent recommendations regarding the efficient adjustment of the principles and instruments of strategic management to the particularities of the SMEs. Thus, the authors intend to clarify the aspects referring to matters such as: the manner of defining the organizational vision and objectives; the drawing up of the strategic options regarding the needed resources (financial, material, human); the understanding of the clien...

  1. The Strategic Positioning of Store Brands in Retailer - Manufacturer Bargaining

    OpenAIRE

    Fiona M. Scott Morton; Florian Zettelmeyer

    2000-01-01

    We argue in this paper that retailers can strategically position store brands in product space to strengthen their bargaining position when negotiating supply terms with manufacturers of national brands. Using a bargaining framework we model a retailer's decision whether to carry an additional national brand or a store brand, and if the retailer chooses to introduce the latter, where in product space to locate the store brand. Store brands differ from other brands in being both unadvertised a...

  2. Strategic plan 1994

    Energy Technology Data Exchange (ETDEWEB)

    1995-03-01

    Sandia National Laboratories faces institutional challenges that are unique in its history. Never before have the national laboratories been viewed so critically, and never before has their role been the subject of such study and debate. At the same time, the opporunities to render `exceptional service in the national interest` have never been greater. The business of Sandia today and into the foreseeable future will rely on a strong, integrated technical foundation, represented most fundamentally by its core competencies. While is is impossible to foresee precisely what missions Sandia will pursue many years from now, one thing is clear: Central to its service to the nation will be the application of science-based engineering skills to the stewardship of the nuclear weapons stockpile. Whether on not the nation ever builds a new nuclear weapon, those that remain in stockpile will require continuous stewardship based on the integration of scientific understanding with experienced systems engineering. Sandia`s steadfast commitment to DOE`s stockpile stewardship mission will also be evident in the production of limited numbers of certain vital weapon components as the weapons production complex is realigned. Complementing this enduring responsibility will be expanded missions in energy, environment, and economic competitiveness. The work for other federal agencies will be jointly sponsored under high-level agreements with DOE. Multi-institutional teams will become a common way of doing business. The multiprogram laboratory model will evolve toward a new model of multi-laboratory programs addressing major national needs. Sandia will be a distinct and important component of an integrated system of national laboratories.

  3. Strategic Analysis Of Innovation-Based Competitiveness In The Global Economy

    OpenAIRE

    Irina Taranenko

    2013-01-01

    In the context of a sustainable development of national economy under the globalization, the innovation-based competitiveness becomes an effective instrument for achieving strategic goals at macro-level. The strategic analysis of innovation-based competitiveness determinants is an important condition of creation an up-to-date national economy model at globalized highly competitive environment. The main purpose of research is to give more specific understanding of innovation competitiveness po...

  4. 2014 Zero Waste Strategic Plan Executive Summary.

    Energy Technology Data Exchange (ETDEWEB)

    Wrons, Ralph J.

    2016-05-01

    Sandia National Laboratories/New Mexico is located in Albuquerque, New Mexico, primarily on Department of Energy (DOE) permitted land on approximately 2,800 acres of Kirtland Air Force Base. There are approximately 5.5 million square feet of buildings, with a workforce of approximately 9200 personnel. Sandia National Laboratories Materials Sustainability and Pollution Prevention (MSP2) program adopted in 2008 an internal team goal for New Mexico site operations for Zero Waste to Landfill by 2025. Sandia solicited a consultant to assist in the development of a Zero Waste Strategic Plan. The Zero Waste Consultant Team selected is a partnership of SBM Management Services and Gary Liss & Associates. The scope of this Plan is non-hazardous solid waste and covers the life cycle of material purchases to the use and final disposal of the items at the end of their life cycle.

  5. Russia’s Non-strategic Nuclear Weapons in Their Current Configuration and Posture: A Strategic Asset or Liability?

    OpenAIRE

    Saradzhyan, Simon

    2010-01-01

    Russia's military-political leadership envisions a formidable range of uses for the country's arsenal of non-strategic nuclear weapons (NSNWs). In the eyes of Russian leaders, these weapons play a critical role in the nation's defense and security posture as part of the country's overall nuclear arsenal and as an equalizer for the weakness of the nation's conventional forces vis-a-vis NATO and China. Russia's military-political leadership and policy influentials also assign a number of specif...

  6. Energy research strategic plan

    International Nuclear Information System (INIS)

    Research and development is an essential element of economic prosperity and a traditional source of strength for the U.S. economy. During the past two decades, the way of introducing technological developments into the national economy has changed steadily. Previously, industry did most long-term technology development and some basic research with private funding. Today, the Nation's industry relies mostly on federally-funded research to provide the knowledge base that leads to new technologies and economic growth. In the 1980s, U.S. firms lost major technology markets to foreign competition. In response, many firms increased emphasis on technology development for near term payoff while decreasing long term research for new technology. The purpose of the Office of Energy Research of the U.S. Department of Energy (DOE) is to provide basic research and technology development that triggers and drives economic development and helps maintain U.S. world leadership in science. We do so through programs of basic and applied research that support the Department's energy, environmental and national defense missions and that provide the foundation for technical advancement. We do so by emphasizing research that maintains our world leadership in science, mathematics, and engineering and through partnerships with universities, National Laboratories, and industries across the Nation

  7. Hydrogen energy and fuel cells. Strategic Roadmap

    International Nuclear Information System (INIS)

    Since 2010, the ADEME (The French Environment and Energy Management Agency) has been managing four programmes within the scope of 'Future Investments'. Groups of experts from research from various industrial fields, research organisms and research programming and financing agencies are responsible, within the scope of collective works, for producing strategic road-maps. These are used to launch Calls for Expressions of Interest (CEI). The purpose of these road-maps is to: - highlight the industrial, technological, environmental and societal issues; - draw up coherent, shared visions of technologies and the socio-technical system in question; - identify the technological, organisational and socio-economic locks to be overcome; - associate time-based objectives with the priority research topics in terms of technological availability and deployment; - prioritise needs of the industrial research, research demonstrator, pre-industrial experimentation and technology test platform, which then act as a basis for: - drawing up CEIs; - programming research within the ADEME and other institutions such as the French National Research Agency (ANR), the French national strategic committee for energy research (Comite strategique national sur la recherche energie) or the French national alliance for the coordination of energy research (ANCRE). These research and experimentation priorities originate from the junction of the visions and locks, and they also take into account French capacities in the fields of research and industry. Road-maps can also refer to exemplary experiments conducted abroad and make recommendations in terms of industrial policy. This road-map shall be regularly updated. In order to draw up this road-map, the ADEME consulted with a group of experts from major private contractors, a contaminated wasteland developer, stakeholders involved in pollution control and public research and finally the ADEME

  8. Developing a strategic plan for a neonatal nurse practitioner service.

    Science.gov (United States)

    Lee, Laurie A; Jones, Luann R

    2004-10-01

    Neonatal nurse practitioners (NNPs) have been in practice for over 3 decades. More recently, NNPs have begun to take ownership for building their group practice models. The purpose of this article is to present a detailed case study demonstrating how one NNP group used a 4-phase strategic planning process to turn a crisis into an opportunity. The article describes data obtained during the strategic planning process from an informal national survey of NNP managers that focused on key benchmarks, such as role definition, responsibilities, protected nonclinical time, NNP salary and benefits, and educational and professional development support. Using the strategic planning process, the group defined mutually agreed upon minimum safe staffing levels for NNPs, interns, residents and neonatologists in their setting. Based on the data generated, the group successfully justified additional NNP positions and organizational support for 10% protected nonclinical time. A sample operational budget, comparison of 3 staffing scenarios, and a timeline are also provided.

  9. NASA ATP Force Measurement Technology Capability Strategic Plan

    Science.gov (United States)

    Rhew, Ray D.

    2008-01-01

    The Aeronautics Test Program (ATP) within the National Aeronautics and Space Administration (NASA) Aeronautics Research Mission Directorate (ARMD) initiated a strategic planning effort to re-vitalize the force measurement capability within NASA. The team responsible for developing the plan included members from three NASA Centers (Langley, Ames and Glenn) as well as members from the Air Force s Arnold Engineering and Development Center (AEDC). After visiting and discussing force measurement needs and current capabilities at each participating facility as well as selected force measurement companies, a strategic plan was developed to guide future NASA investments. This paper will provide the details of the strategic plan and include asset management, organization and technology research and development investment priorities as well as efforts to date.

  10. Environmental Education Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    None

    1991-12-01

    This document is designed to guide the Environmental Education and Development Branch (EM-522) of the EM Office of Technology (OTD) Development, Technology Integration and Environmental Education Division (EM-52) in planning and executing its program through EM staff, Operations Offices, National Laboratories, contractors, and others.

  11. Hepatitis C virus: Virology, diagnosis and management of antiviral therapy

    Institute of Scientific and Technical Information of China (English)

    Stéphane Chevaliez; Jean-Michel Pawlotsky

    2007-01-01

    Hepatitis C virus (HCV) infects approximately 170 million individuals worldwide. Prevention of HCV infection complications is based on antiviral therapy with the combination of pegylatecl interferon alfa and ribavirin.The use of serological and virological tests has become essential in the management of HCV infection in order to diagnose infection, guide treatment decisions and assess the virological response to antiviral therapy. Anti-HCV antibody testing and HCV RNA testing are used to diagnose acute and chronic hepatitis C. The HCV genotype should be systematically determined before treatment, as it determines the indication, the duration of treatment,the dose of ribavirin and the virological monitoring procedure. HCV RNA monitoring during therapy is used to tailor treatment duration in HCV genotype 1 infection, and molecular assays are used to assess the end-of-treatment and, most importantly the sustained virological response,i.e. the enlpoint of therapy.

  12. Antiviral Effect of Matrine against Human Enterovirus 71

    Directory of Open Access Journals (Sweden)

    Jiangning Liu

    2012-08-01

    Full Text Available Human enterovirus 71, a member of the Picornaviridae family, is one of the major causative agent of hand, foot and mouth disease in children less than six years old. This illness has caused mortalities in large-scale outbreaks in the Asia-Pacific region in recent years. No vaccine or antiviral therapy is available. In this study, antiviral effect of matrine against enterovirus 71 were evaluated in vitro and in vivo. Matrine could suppress the viral RNA copy number on rhabdomyosarcoma cells. Moreover, matrine treatment of mice challenged with a lethal dose of enterovirus 71 reduced the mortality and relieved clinical symptoms. The results showed that matrine may represent a potential therapeutic agent for enterovirus 71 infection.

  13. A model for strategic leadership.

    Science.gov (United States)

    Carver, J

    1989-01-01

    Boards can exercise strategic leadership, but to do so well, they must change their concept of governance. Most of what is traditionally accepted in the boardroom is not conducive to excellence in strategic leadership and, in fact, actually impedes it. First, trustees must be able to escape the clutter that interferes with a continual emphasis on strategic issues. This calls for a far more incisive way to withdraw responsibility from administrative tissues in favor of control by policy. Second, trustees must understand that strategic leadership is a matter of how the board approaches its job, not a mechanical annual tussle with setting long-range goals. Third, trustees must structure their annual plans around updating their long-range intentions--chiefly concerning mission issues and priorities--and restating them in amended ends policies. Finally, trustees must realize that strategic leadership--hence, good governance--is not so much about budgets, personnel practices, construction projects or medical staff bylaws as it is about public policy, purpose, values and the vision that shapes institutional destiny. PMID:10295445

  14. Strategic Management in Radiology Department

    Directory of Open Access Journals (Sweden)

    Arash Deljou

    2009-01-01

    Full Text Available "nA radiologist makes literally hundreds of decisions each day, but once each of those decisions is made, the case is finished. The radiologist is free to move on to the next set of decisions. Radiology practice administrators, in contrast, may be tied up solidly for 6 months while carrying out one business decision. The decision-making processes, environments, and timetables differ so greatly between physicians and administrators that bridging those cultural gaps becomes, in itself, an important step in planning, strategic and operational. "nOne of the main premise is that there is no “Holy Grail” to be found in strategic management, only an understanding that planning and change are the responsibility of senior management in radiology sector. "nIn fact, it is now their primary job in today’s radiology world of constant change, “Analogue to Digital”.  "nExcellent organizations don’t just have a budgeting cycle each year; they have a “strategic management” cycle led by senior management as they work on the organization, rather than just in the organization. As planning is just the first function of management, and strategic planning is just the highest order of planning and the purview of senior management in every radiology department, then every department has three basic goals: "n1. Develop strategic and operational plans. "n2. Ensure their successful implementation and change. "n3. Build and sustain high performance over the long term.  

  15. Strategic Networks for Sustainable Tourism Development

    Directory of Open Access Journals (Sweden)

    Ivelyna Krasteva Yoveva

    2014-12-01

    Full Text Available This paper proposes an innovative approach towards introduction of an up-to-date sustainable development philosophy founded on the principles of combination and balance of common and individual interests on multilateral perspective, i.e. individuals vs. organizations, public groups vs. governmental authorities, industry vs. macroeconomic development, nation states vs. international regional development etc. The optimal implementation of such an approach is imminently dependent on an authentic self-awareness of own identity, values, purposes and motivation for positive contribution to the common well-being. The author’s arguments are based on the conviction that when more individuals and organizations harness deeper understanding of the mutual benefits within their operations area and undertake collaborative efforts to solve common problem their steadfast long-term development may be secured even in times of social-economic-political-eco-etc. crises and within a dynamically changing environment.Main purpose of current article is the concentration of the research on looking for and applying the principles of consistency, exchange of good collaborative practices and consequently strategic and operational utilization of the synergy effect, systems thinking and the holistic approach. Collaborative efforts would lead to greater effectiveness and optimization that satisfies individual and common interests in multiple environmental dimensions. The study aims to analyze the potential of a new network paradigm for provision of effectively applied strategies within the contemporary sustainable development context.Some good practices within the area of joint development of sustainable strategic networks in tourism industry in Bulgaria are presented. A case study of a culinary and hospitality cluster recently established in the Dobrudzha region is about to demonstrates the strategic network viability and sustainability in a contemporary agricultural

  16. Carbohydrate recognition by the antiviral lectin cyanovirin-N

    OpenAIRE

    Fujimoto, Yukiji K.; Green, David F.

    2012-01-01

    Cyanovirin-N is a cyanobacterial lectin with potent antiviral activity, and has been the focus of extensive pre-clinical investigation as a potential prophylactic for the prevention of the sexual transmission of the human immunodeficiency virus (HIV). Here we present a detailed analysis of carbohydrate recognition by this important protein, using a combination of computational methods, including extensive molecular dynamics simulations and Molecular-Mechanics/ Poisson–Boltzmann/Surface-Area (...

  17. Antiviral therapy for hepatitis B virus associated hepatic failure

    Institute of Scientific and Technical Information of China (English)

    Yu-Ming Wang; Ying-Zi Tang

    2009-01-01

    BACKGROUND: Chronic hepatitis B virus (HBV) infection remains a major global health issue, and the prognosis of patients with HBV-associated fulminant hepatic failure is extremely poor. The application of antiviral therapies has led to signiifcant improvements in patient outcomes. This article aimed to review the current strategies in antiviral treatment of HBV-associated fulminant hepatic failure. DATA SOURCES: Literature search was conducted using PubMed on the related subjects. Part of the data was from the most recent work of the authors' laboratory. RESULTS: Hepatitis B immunoglobulin in prevention of recurrent HBV infection after orthotopic liver transplantation (OLT) has been proven effective. However, its cost is high, and signiifcant side effects have been found to induce viral mutations. Lamivudine has a potent suppression for HBV replication and an excellent safety proifle in decompensated cirrhotic patients, but its major drawback is the high rate of drug-resistance. Adefovir is effective for lamivudine-resistance strains in the post-OLT situation, and its drug-resistance rate is relatively low. Combination therapies such as hepatitis B immunoglobulin combined with lamivudine and lamivudine combined with adefovir have been widely adopted for prophylaxis against HBV recurrence of infection after OLT. Entecavir, telbivudine, tenofovir and other newer agents have been widely used in antiviral therapy. CONCLUSIONS: The prognosis of HBV-associated ful-minant hepatic failure is being transformed by developments in antiviral therapy. However, it should be noticed that HBV is controlled but never eliminated, and drug-resistance still remains a major issue. Hopefully, newer strategies may help to solve these problems.

  18. Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin

    OpenAIRE

    Romina Croci; Elisabetta Bottaro; Kitti Wing Ki Chan; Satoru Watanabe; Margherita Pezzullo; Eloise Mastrangelo; Claudio Nastruzzi

    2016-01-01

    RNA virus infections can lead to the onset of severe diseases such as fever with haemorrhage, multiorgan failure, and mortality. The emergence and reemergence of RNA viruses continue to pose a significant public health threat worldwide with particular attention to the increasing incidence of flaviviruses, among others Dengue, West Nile Virus, and Yellow Fever viruses. Development of new and potent antivirals is thus urgently needed. Ivermectin, an already known antihelminthic drug, has shown ...

  19. Antiviral effects of bovine interferons on bovine respiratory tract viruses.

    OpenAIRE

    Fulton, R W; Downing, M M; Cummins, J M

    1984-01-01

    The antiviral effects of bovine interferons on the replication of bovine respiratory tract viruses were studied. Bovine turbinate monolayer cultures were treated with bovine interferons and challenged with several bovine herpesvirus 1 strains, bovine viral diarrhea virus, parainfluenza type 3 virus, goat respiratory syncytial virus, bovine respiratory syncytial virus, bovine adenovirus type 7, or vesicular stomatitis virus. Treatment with bovine interferons reduced viral yield for each of the...

  20. In vitro antiviral effect of germacrone on feline calicivirus.

    Science.gov (United States)

    Wu, Hongxia; Liu, Yongxiang; Zu, Shaopo; Sun, Xue; Liu, Chunguo; Liu, Dafei; Zhang, Xiaozhan; Tian, Jin; Qu, Liandong

    2016-06-01

    Feline calicivirus (FCV) often causes respiratory tract and oral disease in cats and is a highly contagious virus. Widespread vaccination does not prevent the spread of FCV. Furthermore, the low fidelity of the RNA-dependent RNA polymerase of FCV leads to the emergence of new variants, some of which show increased virulence. Currently, few effective anti-FCV drugs are available. Here, we found that germacrone, one of the main constituents of volatile oil from rhizoma curcuma, was able to effectively reduce the growth of FCV strain F9 in vitro. This compound exhibited a strong anti-FCV effect mainly in the early phase of the viral life cycle. The antiviral effect depended on the concentration of the drug. In addition, germacrone treatment had a significant inhibitory effect against two other reference strains, 2280 and Bolin, and resulted in a significant reduction in the replication of strains WZ-1 and HRB-SS, which were recently isolated in China. This is the first report of antiviral effects of germacrone against a calicivirus, and extensive in vivo research is needed to evaluate this drug as an antiviral therapeutic agent for FCV. PMID:26997613

  1. Antiviral drug discovery against SARS-CoV.

    Science.gov (United States)

    Wu, Yu-Shan; Lin, Wen-Hsing; Hsu, John T-A; Hsieh, Hsing-Pang

    2006-01-01

    Severe Acute Respiratory Syndrome (SARS) is a life-threatening infectious disease caused by SARS-CoV. In the 2003 outbreak, it infected more than 8,000 people worldwide and claimed the lives of more than 900 victims. The high mortality rate resulted, at least in part, from the absence of definitive treatment protocols or therapeutic agents. Although the virus spreading has been contained, due preparedness and planning, including the successful development of antiviral drugs against SARS-CoV, is necessary for possible reappearance of SARS. In this review, we have discussed currently available strategies for antiviral drug discovery and how these technologies have been utilized to identify potential antiviral agents for the inhibition of SARS-CoV replication. Moreover, progress in the drug development based on different molecular targets is also summarized, including 1) Compounds that block the S protein-ACE2-mediated viral entry; 2) Compounds targeting SARS-CoV M(pro); 3) Compounds targeting papain-like protease 2 (PLP2); 4) Compounds targeting SARS-CoV RdRp; 5) Compounds targeting SARS-CoV helicase; 6) Active compounds with unspecified targets; and 7) Research on siRNA. This review aims to provide a comprehensive account of drug discovery on SARS. The experiences with the SARS outbreak and drug discovery would certainly be an important lesson for the drug development for any new viral outbreaks that may emerge in the future.

  2. Antioxidants: potential antiviral agents for Japanese encephalitis virus infection.

    Science.gov (United States)

    Zhang, Yu; Wang, Zehua; Chen, Huan; Chen, Zongtao; Tian, Yanping

    2014-07-01

    Japanese encephalitis (JE) is prevalent throughout eastern and southern Asia and the Pacific Rim. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. Despite the importance of JE, little is known about its pathogenesis. The role of oxidative stress in the pathogenesis of viral infections has led to increased interest in its role in JEV infections. This review focuses mainly on the role of oxidative stress in the pathogenesis of JEV infection and the antiviral effect of antioxidant agents in inhibiting JEV production. First, this review summarizes the pathogenesis of JE. The pathological changes include neuronal death, astrocyte activation, and microglial proliferation. Second, the relationship between oxidative stress and JEV infection is explored. JEV infection induces the generation of oxidants and exhausts the supply of antioxidants, which activates specific signaling pathways. Finally, the therapeutic efficacy of a variety of antioxidants as antiviral agents, including minocycline, arctigenin, fenofibrate, and curcumin, was studied. In conclusion, antioxidants are likely to be developed into antiviral agents for the treatment of JE. PMID:24780919

  3. Antiviral and antimicrobial assessment of some selected flavonoids.

    Science.gov (United States)

    Ozçelik, Berrin; Orhan, Ilkay; Toker, Gülnur

    2006-01-01

    In the current study, the results of antibacterial, antifungal, and antiviral activity tests of four flavonoid derivatives, scandenone (1), tiliroside (2), quercetin-3,7-O-alpha-L-dirhamnoside (3), and kaempferol-3,7-O-alpha-L-dirhamnoside (4), are presented. Antibacterial and antifungal activities of these compounds were tested against Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Bacillus subtilis, and Enterococcus faecalis, as well as the fungus Candida albicans by a micro-dilution method. On the other hand, both DNA virus Herpes simplex (HSV) and RNA virus Parainfluenza-3 (PI-3) were employed for antiviral assessment of the compounds using Madin-Darby bovine kidney and Vero cell lines. According to our data, all of the compounds tested were found to be quite active against S. aureus and E. faecalis with MIC values of 0.5 microg/ml, followed by E. coli (2 microg/ml), K. pneumoniae (4 microg/ml), A. baumannii (8 micro/g/ml), and B. subtilis (8 microg/ml), while they inhibited C. albicans at 1 microg/ml as potent as ketoconazole. However, only compound 3 displayed an antiviral effect towards PI-3 in the range of 8-32 microg/ml of inhibitory concentration for cytopathogenic effect (CPE).

  4. Iron metabolism in chronic hepatitis C patients on antiviral treatment

    Directory of Open Access Journals (Sweden)

    K. V. Zhdanov

    2009-01-01

    Full Text Available Purpose of the present research studying dynamics of the parameters describing a metabolism of iron at chronic hepatitis С patients on a combined antiviral therapy peg-interferon-2а and ribavirin. Has served 50 patients chronic hepatitis C (anti-HCV “+”, РНК HCV “+”, 1b genotype in the age from 18 till 59 years, on the average 33±1,5years, at various stages of disease and stages of monitoring antiviral treatments. To patients the parameters describing a metabolism of iron (serum iron, transferrin, ferritin, haptoglobin, ceruplasmin, total iron binding capacity, transferrin saturation by iron were defined. The sustain virology response (SVR was estimated - definition RNA HCV in half a year after end of treatment (72 week. It was carried out liver biopsy with the subsequent estimation of a degree of inflammatory activity and fibrosis on system METAVIR. Therapy peg-interferon-2а and ribavirin was accompanied by decrease serum iron, transferrin, ferritin, ceruplasmin, haptoglobin, transferrin saturation by iron irrespective of the answer to treatment. Thus, SVR directly correlated with higher level of iron and ceruplasmin of blood before therapy, on its background and during supervision. Normalization of biochemical activity chronic hepatitis C and positive morphological dynamics correspond with the parameters describing changes in a metabolism of iron at its patients, possibly, were compensatory-adaptive and to some extent endogen antiviral reaction of an organism of the person on HCV - infection. 

  5. Drug delivery approaches of an antiviral drug: A comprehensive review

    Directory of Open Access Journals (Sweden)

    Ramya Devi Durai

    2015-01-01

    Full Text Available The guanine derivative antiviral drug acyclovir (ACV is one of the oldest molecules laying successful market until date, being commercially available in various dosage forms for oral, topical and parenteral administrations. Clinical application of this drug is superior to new antiviral agents due to its potential values such as suppression of recurrence, safety profile, minimal drug interactions, and being inexpensive. ACV is slightly water-soluble, less permeable and poorly bioavailable, yet more potential antiviral molecule, the physicochemical modifications and novel dosage form approaches resulted with more than 100 research works within a decade. The survey of literature showed enormous reports on ACV formulation development, which includes modified tablets, particulate drug delivery, vesicular drug delivery, polymeric nanoparticles, bioadhesive systems, floating dosage forms, in situ gelling systems, transdermal delivery, implantable systems, emulsified dosage forms, polymeric films/patches, etc. As the drug could be administered via multiple routes for effective site targeted action at various doses, and attracted the attention of many researches, the review of the current approaches for the delivery of ACV could be more beneficial for the new scientists. This paper is a review of recent researches highlighting the development of newer techniques and novel dosage forms of ACV for better therapeutic efficacy, which were aimed at enhancing its solubility, permeability and bioavailability.

  6. Antiviral activity of some South American medicinal plants.

    Science.gov (United States)

    Abad, M J; Bermejo, P; Sanchez Palomino, S; Chiriboga, X; Carrasco, L

    1999-03-01

    Folk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Extracts prepared from 10 South American medicinal plants (Baccharis trinervis, Baccharis teindalensis, Eupatorium articulatum, Eupatorium glutinosum, Tagetes pusilla, Neurolaena lobata, Conyza floribunda, Phytolacca bogotensis, Phytolacca rivinoides and Heisteria acuminata) were screened for in vitro antiviral activity against herpes simplex type I (HSV-1), vesicular stomatitis virus (VSV) and poliovirus type 1. The most potent inhibition was observed with an aqueous extract of B. trinervis, which inhibited HSV-1 replication by 100% at 50-200 micrograms/mL, without showing cytotoxic effects. Good activities were also found with the ethanol extract of H. acuminata and the aqueous extract of E. articulatum, which exhibited antiviral effects against both DNA and RNA viruses (HSV-1 and VSV, respectively) at 125-250 micrograms/mL. The aqueous extracts of T. pusilla (100-250 micrograms/mL), B. teindalensis (50-125 micrograms/mL) and E. glutinosum (50-125 micrograms/mL) also inhibited the replication of VSV, but none of the extracts tested had any effect on poliovirus replication. PMID:10190189

  7. The Emerging Strategic Entrepreneurship Field

    DEFF Research Database (Denmark)

    Foss, Nicolai Juul; Lyngsie, Jacob

    considered jointly. The purpose of this brief chapter is to explain the emergence of SE theory field in terms of a response to research gaps in the neighboring fields of entrepreneurship and strategic management; describe the main tenets of SE theory; discuss its relations to neighboring fields; and finally......The field of strategic entrepreneurship is a fairly recent one. Its central idea is that opportunity-seeking and advantage-seeking — the former the central subject of the entrepreneurship field, the latter the central subject of the strategic management field — are processes that need to be...... describe some research gaps in extant theory, mainly focusing on the need to provide clear microfoundations for SE theory and link it to organizational design theory....

  8. Using Intellectual Property Rights Strategically

    DEFF Research Database (Denmark)

    Reitzig, Markus

    2003-01-01

    With the share of intellectual property among corporate value constantly rising,management's understanding of the strategic use of patents, trademarks, andcopyrights becomes ever more crucial. The vast majority of articles on patent ortrademark strategies, however, is written by and for lawyers...... describing advancedprocedural legal tactics but not addressing the problems faced by managers. Onthe other hand, the marketing, technology management, and economics literatureprovides important basic insights to managerial aspects of IPRs but does hardlyexpand on the fundamental knowledge so that it would...... in various industries, this articleattempts at defining the content of an `intellectual property strategy' from theperspective of a strategic management scholar by linking the use of IPRs to aseries of strategic management questions. Ultimately, the paper helps strategicmanagers to understand recent...

  9. Corporate Foresight and Strategic Decisions

    DEFF Research Database (Denmark)

    Gomez Portaleoni, Claudio; Marinova, Svetla Trifonova; Ul-Haq, Rehan;

    . It provides an extensive analysis of extant theories of corporate foresight and strategic management, brings in new notions and insights, and presents an in-depth case study exploration of corporate foresight of a European bank. The understanding of organizational future is influenced by the perceived...... dealt successfully with internal information sharing processes that in most cases have prepared them for the challenges of the future. Corporate Foresights and Strategic Decisions investigates the relationships between corporate foresight and management decision-making processes in organizations...... accountability and integrity of the participating departments as well as by the apparent nature of environmental explosiveness. This book provides clear confirmations showing that the impacts of corporate foresight on strategic decisions are critically affected by the evaluative and analytical verdicts...

  10. Managing transdisciplinarity in strategic foresight

    DEFF Research Database (Denmark)

    Rasmussen, Birgitte; Andersen, Per Dannemand; Borch, Kristian

    2010-01-01

    strategic foresight has now been widely accepted for strategy-making and priority-setting in science and innovation policy, the methodologies underpinning it still need further development. Key findings are the identification of challenges, aspects and issues related to management and facilitation......Strategic foresight deals with the long term future and is a transdisciplinary exercise which, among other aims, addresses the prioritization of science and other decision making in science and innovation advisory and funding bodies. This article discusses challenges in strategic foresight...... to negotiate over how to attain a desirable future. This requires creative thinking from the participants, who need to extend their knowledge into the uncertainty of the future. Equally important is skilled facilitating in order to create a space for dialogue and exploration in a contested territory. Although...

  11. NATO's Strategic Partnership with Ukraine

    DEFF Research Database (Denmark)

    Breitenbauch, Henrik Ø.

    2014-01-01

    Russian actions in Ukraine have altered the security land- scape in Europe, highlighting a renewed emphasis on the differences between members and non-members. In this context, NATO must a) create a strategic understanding of partnerships as something that can be transformative, even if it will n......Russian actions in Ukraine have altered the security land- scape in Europe, highlighting a renewed emphasis on the differences between members and non-members. In this context, NATO must a) create a strategic understanding of partnerships as something that can be transformative, even...... if it will not lead to membership in the short or even long term, and b) build such a strategic relationship with Ukraine. In sum, the Russian-induced Ukraine crisis should spur the reform of NATO partnerships – with Ukraine as a case in point....

  12. Strategic Leadership of Corporate Sustainability

    DEFF Research Database (Denmark)

    Strand, Robert

    2014-01-01

    ? What effects do corporate sustainability TMT positions have at their organizations? We consider these questions through strategic leadership and neoinstitutional theoretical frameworks. Through the latter, we also engage with Weberian considerations of bureaucracy. We find that the reasons why......Strategic leadership and corporate sustainability have recently come together in conspicuously explicit fashion through the emergence of top management team (TMT) positions with dedicated corporate sustainability responsibilities. These TMT positions, commonly referred to as 'Chief Sustainability...... unrealized without concerted attention and coordination afforded by a strategic level position. Regarding effects, we determine the position can relate to the establishment of bureaucratic structures dedicated to corporate sustainability within the corporation through which formalized processes and key...

  13. Strategic planning in healthcare organizations.

    Science.gov (United States)

    Rodríguez Perera, Francisco de Paula; Peiró, Manel

    2012-08-01

    Strategic planning is a completely valid and useful tool for guiding all types of organizations, including healthcare organizations. The organizational level at which the strategic planning process is relevant depends on the unit's size, its complexity, and the differentiation of the service provided. A cardiology department, a hemodynamic unit, or an electrophysiology unit can be an appropriate level, as long as their plans align with other plans at higher levels. The leader of each unit is the person responsible for promoting the planning process, a core and essential part of his or her role. The process of strategic planning is programmable, systematic, rational, and holistic and integrates the short, medium, and long term, allowing the healthcare organization to focus on relevant and lasting transformations for the future.

  14. Limited rationality and strategic interaction

    DEFF Research Database (Denmark)

    Fehr, Ernst; Tyran, Jean-Robert

    2008-01-01

    Much evidence suggests that people are heterogeneous with regard to their abilities to make rational, forward-looking decisions. This raises the question as to when the rational types are decisive for aggregate outcomes and when the boundedly rational types shape aggregate results. We examine...... this question in the context of a long-standing and important economic problem: the adjustment of nominal prices after an anticipated monetary shock. Our experiments suggest that two types of bounded rationality-money illusion and anchoring-are important behavioral forces behind nominal inertia. However......, depending on the strategic environment, bounded rationality has vastly different effects on aggregate price adjustment. If agents' actions are strategic substitutes, adjustment to the new equilibrium is extremely quick, whereas under strategic complementarity, adjustment is both very slow and associated...

  15. An Overview of the NASA Aeronautics Test Program Strategic Plan

    Science.gov (United States)

    Marshall, Timothy J.

    2010-01-01

    U.S. leadership in aeronautics depends on ready access to technologically advanced, efficient, and affordable aeronautics test capabilities. These systems include major wind tunnels and propulsion test facilities and flight test capabilities. The federal government owns the majority of the major aeronautics test capabilities in the United States, primarily through the National Aeronautics and Space Administration (NASA) and the Department of Defense (DoD), however an overarching strategy for management of these national assets was needed. Therefore, in Fiscal Year (FY) 2006 NASA established the Aeronautics Test Program (ATP) as a two-pronged strategic initiative to: (1) retain and invest in NASA aeronautics test capabilities considered strategically important to the agency and the nation, and (2) establish a strong, high level partnership with the DoD Test Resources Management Center (TRMC), stewards of the DoD test and evaluation infrastructure. Since then, approximately seventy percent of the ATP budget has been directed to underpin fixed and variable costs of facility operations within its portfolio and the balance towards strategic investments in its test facilities, including maintenance and capability upgrades. Also, a strong guiding coalition was established through the National Partnership for Aeronautics Testing (NPAT), with governance by the senior leadership of NASA s Aeronautics Research Mission Directorate (ARMD) and the DoD's TRMC. As part of its strategic planning, ATP has performed or participated in many studies and analyses, including assessments of major NASA and DoD aeronautics test capabilities, test facility condition evaluations and market research. The ATP strategy has also benefitted from unpublished RAND research and analysis by Ant n et al. (2009). Together, these various studies, reports and assessments serve as a foundation for a new, five year strategic plan that will guide ATP through FY 2014. Our vision for the future is a balanced

  16. Final Draft Strategic Marketing Plan.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1994-02-01

    The Bonneville Power Administration (BPA) has developed a marketing plan to define how BPA can be viable and competitive in the future, a result important to BPA`s customers and constituents. The Marketing Plan represents the preferred customer outcomes, marketplace achievements, and competitive advantage required to accomplish the Vision and the Strategic Business Objectives of the agency. The Marketing Plan contributes to successful implementation of BPA`s Strategic Business Objectives (SBOs) by providing common guidance to organizations and activities throughout the agency responsible for (1) planning, constructing, operating, and maintaining the Federal Columbia River Power System; (2) conducting business with BPA`s customers; and (3) providing required internal support services.

  17. Is Strategic Entrepreneurship a Pleonasm?

    OpenAIRE

    2013-01-01

    A plethora of terms have been used to describe the notion of entrepreneurial and innovative orientation and action within organizations. While ¡®corporate¡¯ and ¡®entrepreneurship¡¯ coupled together in one term can be viewed as antithetical by some, is the arrival of its newer cousin ¡®strategic entrepreneurship¡¯ essentially the same notion? Irrespective of how opinions and logic may pivot on this debate, strategic entrepreneurship nevertheless seems to have some of the markings of an admitt...

  18. Contrasting strategic and Milan therapies.

    Science.gov (United States)

    MacKinnon, L

    1983-12-01

    Three related models of therapy are often grouped together as the strategic therapies. These are brief therapy model associated with the Mental Research Institute, approaches developed by Jay Haley and Cloë Madanes, and the model developed by the Milan associates. Controversy exists, however, as to whether the Milan model should be included as a strategic therapy. It appears that the similarities among the three models can mask deeper differences, thus confounding the confusion. This paper contrast the models in their development, theory, and practice.

  19. Issues in Strategic Decision Modelling

    CERN Document Server

    Jennings, Paula

    2008-01-01

    [Spreadsheet] Models are invaluable tools for strategic planning. Models help key decision makers develop a shared conceptual understanding of complex decisions, identify sensitivity factors and test management scenarios. Different modelling approaches are specialist areas in themselves. Model development can be onerous, expensive, time consuming, and often bewildering. It is also an iterative process where the true magnitude of the effort, time and data required is often not fully understood until well into the process. This paper explores the traditional approaches to strategic planning modelling commonly used in organisations and considers the application of a real-options approach to match and benefit from the increasing uncertainty in today's rapidly changing world.

  20. Aktivitas Antiviral Minyak Atsiri Jahe Merah terhadap Virus Flu Burung (ANTIVIRAL ACTIVITY OF ESSENSIAL OIL RED GINGER ON AVIAN INFLUENZA)

    OpenAIRE

    Tri Untari; Sitarina Widyarini; Michael Haryadi Wibowo

    2013-01-01

    The studies have reported that ginger have many activities such as antiemesis, anti-inflammatory,anti-bacterial and anti-parasites. Therefore, this study was conducted to evaluate antiviral effect of essentialred ginger oil againts Avian Influenza (AI) in ovo using hemagglutination test (HA). Avian Influenzaviruses were treated with 0,01%, 0,1% and 1% of essential red ginger oil, and then inoculated in chickenembryonated egg via allantoic sac. Allantoic fluid was harvested using for HA test ....

  1. Strategic Planning and Strategic Thinking Clothed in STRATEGO

    Science.gov (United States)

    Baaki, John; Moseley, James L.

    2011-01-01

    This article shares experiences that participants had playing the game of STRATEGO and how the activity may be linked to strategic planning and thinking. Among the human performance technology implications of playing this game are that gamers agreed on a framework for rules, took stock on where they wanted to go in the future, and generated a risk…

  2. The strategic labor allocation proces : a model of strategic HRM

    NARCIS (Netherlands)

    Bax, Erik H.

    2002-01-01

    In this article the Strategic Labor Allocation Process model (SLAP) is described. The model relates HR-strategies to structure, culture and task technology to HR-policies like recruitment, appraisal and rewarding, to business strategy and to socio-cultural, economic, institutional and technological

  3. Chemistry and Materials Science Strategic Plan

    Energy Technology Data Exchange (ETDEWEB)

    Rhodie, K B; Mailhiot, C; Eaglesham, D; Hartmann-Siantar, C L; Turpin, L S; Allen, P G

    2004-04-21

    Lawrence Livermore National Laboratory's mission is as clear today as it was in 1952 when the Laboratory was founded--to ensure our country's national security and the safety and reliability of its nuclear deterrent. As a laboratory pursuing applied science in the national interest, we strive to accomplish our mission through excellence in science and technology. We do this while developing and implementing sound and robust business practices in an environment that emphasizes security and ensures our safety and the safety of the community around us. Our mission as a directorate derives directly from the Laboratory's charter. When I accepted the assignment of Associate Director for Chemistry and Materials Science (CMS), I talked to you about the need for strategic balance and excellence in all our endeavors. We also discussed how to take the directorate to the next level. The long-range CMS strategic plan presented here was developed with this purpose in mind. It also aligns with the Lab's institutional long-range science and technology plan and its 10-year facilities and infrastructure site plan. The plan is aimed at ensuring that we fulfill our directorate's two governing principles: (1) delivering on our commitments to Laboratory programs and sponsors, and (2) anticipating change and capitalizing on opportunities through innovation in science and technology. This will require us to attain a new level of creativity, agility, and flexibility as we move forward. Moreover, a new level of engagement in partnerships with other directorates across the Laboratory as well as with universities and other national labs will also be required. The group of managers and staff that I chartered to build a strategic plan identified four organizing themes that define our directorate's work and unite our staff with a set of common goals. The plan presented here explains how we will proceed in each of these four theme areas: (1) Materials properties and

  4. The Danish experience of strategic environment assesment

    DEFF Research Database (Denmark)

    Kørnøv, Lone

    2004-01-01

    The article recounts a number of examples of the Danish experience with Strategic Environmental Assessment (SEA).......The article recounts a number of examples of the Danish experience with Strategic Environmental Assessment (SEA)....

  5. Are human resource professionals strategic business partners?

    DEFF Research Database (Denmark)

    Chiu, Randy; Selmer, Jan

    2011-01-01

    Theoretical speculations and prescriptive discussions abound in the literature regarding the strategic importance of human resource management. However, evidence based on rigorous empirical studies that the transformation from an administrative service function to strategic partnership has taken...

  6. Evaluation of antiviral activity of plant extracts against foot and mouth disease virus in vitro.

    Science.gov (United States)

    Younus, Ishrat; Siddiq, Afshan; Ishaq, Humera; Anwer, Laila; Badar, Sehrish; Ashraf, Muhammad

    2016-07-01

    The aim of this study was to evaluate antiviral activity of chloroformic leaves extracts of three plants: Azadirachta indica, Moringa oleifera and Morus alba against Foot and Mouth disease virus using MTT assay (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide). Antiviral and cytotoxic activity of each extract was evaluated as cell survival percentage and results were expressed as Means ± S.D. The concentrations which resulted in cell survival percentages of greater than 50% are considered to be effective antiviral concentrations. From the tested plant extracts, Moringa oleifera showed potent antiviral activity (p<0.05) while Azadirachta indica showed significant antiviral activity in the range of 1-50μ/ml & 12-100μ/ml respectively. In contrast no antiviral activity was observed by Morus alba as all the tested concentration resulted in significant reduction (p<0.05) in cell survival percentage. PMID:27393440

  7. Total Synthesis and Anti-Viral Activities of an Extract of Radix isatidis

    Directory of Open Access Journals (Sweden)

    Li-Wei He

    2014-12-01

    Full Text Available Radix isatidis (Banlangen, a famous traditional Chinese medicine, has been used for thousands of years in China due to its anti-viral activity. Through our research, we inferred that the anti-viral activity of Radix isatidis depended on the water-soluble part. Among the components of this extract, the isoquinoline derivative 1 was isolated for the first time and has shown better anti-viral activity than other constituents. In this study, to solve the problem of sourcing sufficient quantities of compound 1, a total synthesis route is described, and several analogues are also evaluated for their anti-viral activities. Among them, compound 8 shown potent anti-viral activity with an IC50 value of 15.3 µg/mL. The results suggested that isoquinoline derivatives possessed potent anti-viral activity and are worthy further development.

  8. Studies on the Antiviral Activities in vitro of Polysaccharide from Eucheuma striatum

    Institute of Scientific and Technical Information of China (English)

    CEN,Ying-Zhou; KHOO,Gaik-Ming; YE,Shao-Ming; RUI,Wen

    2004-01-01

    @@ To assay the antiviral activities on HSV-1 and CVB3 in vitro of the polysaccharide from Eucheuma striatum, its antiviral mechanism was explored. Vero cells were infected by HSV-1 and CVB3, and they were cultured with serial dilutions of polysaccharide. The cells cytotoxicity of Polysaccharide was evaluated by the MTT method. The inhibitory effects were evaluated by the cytopathic effect (CPE). Its antiviral mechanism was researched by the method of giving samples in different time. The polysaccharide could inhibit the CPE of cells infected by HSV-1 and CVB3. It showed low cytotoxicity on vero cells. Its antiviral activities were better than those of acyclovir and ribavirin which were run in parallel as the positive control samples. The polysaccharide from Eucheuma striatum has potent antiviral activities. Its antiviral mechanism is that it can prevent the virus from absorbing to the cell surface.

  9. Strategic Listening for School Leaders

    Science.gov (United States)

    Tate, Jeannine S.; Dunklee, Dennis R.

    2005-01-01

    The ability to communicate effectively with multiple constituencies is recognized as an essential characteristic of effective leaders. Listening strategically is a way of showing parents, students, faculty, staff, and others that their ideas and beliefs are of value. The authors' practitioner-friendly book concentrates on the importance of…

  10. Strategic petroleum reserve annual report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-15

    Section 165 of the Energy Policy and Conservation Act (Public Law 94- 163), as amended, requires the Secretary of Energy to submit annual reports to the President and the Congress on activities of the Strategic Petroleum Reserve (SPR). This report describes activities for the year ending December 31, 1995.

  11. Strategic Asset Seeking by EMNEs

    DEFF Research Database (Denmark)

    Petersen, Bent; Seifert, Jr., Rene E.

    2014-01-01

    Purpose: The chapter provides an economic explanation and perspectivation of strategic asset seeking of multinational enterprises from emerging economies (EMNEs) as a prominent feature of today’s global economy. Approach: The authors apply and extend the “springboard perspective.” This perspectiv...

  12. Strategic interactions in environmental economics

    NARCIS (Netherlands)

    Heijnen, Pim

    2007-01-01

    This thesis deals with the strategic interactions important to environmental economics. That includes a wide range of topics: environmental groups influencing or informing consumers, the reaction to taxation by car and fuel producers, the spread of an innovative tax and binary public good games.

  13. Corporate Social Responsibility: Strategic Implications

    OpenAIRE

    Abagail McWilliams; Siegel, Donald S.; Patrick M. Wright

    2005-01-01

    We describe a variety of perspectives on corporate social responsibility (CSR), which we use to develop a framework for consideration of the strategic implications of CSR. Based on this framework, we propose an agenda for additional theoretical and empirical research on CSR. We then review the papers in this special issue and relate them to the proposed agenda.

  14. Strategic alliances : fit or failure

    NARCIS (Netherlands)

    Douma, Marc Ulco

    1997-01-01

    Strategic alliances have come to form a structural element within present day economic systems. In spite of a considerable increase in the number of alliances, in practice these are quite often less successful than initially anticipated by the partners involved. These two observations formed the imm

  15. The Test of Strategic Culture

    DEFF Research Database (Denmark)

    Dalgaard-Nielsen, Anja

    2005-01-01

    that have so far framed the reunified Germany’s military policy. Iraq simply showed that Germany, like most other countries, has conditions that have to be met – in Germany’s case, conditions flowing from the coexistence of two competing schools of thought within Germany’s strategic culture....

  16. A strategic PACS maturity approach

    NARCIS (Netherlands)

    van de Wetering, R.

    2011-01-01

    Finding the key determinants of Picture Archivingand Communication Systems (PACS)performance in hospitals has been a conundrumfor decades. This research provides a method toassess the strategic alignment of PACS in hospitalsin order to find these key determinants. PACS touches upon every single part

  17. Entrepreneurial Spirit in Strategic Planning.

    Science.gov (United States)

    Riggs, Donald E.

    1987-01-01

    Presents a model which merges the concepts of entrepreneurship with those of strategic planning to create a library management system. Each step of the process, including needs assessment and policy formation, strategy choice and implementation, and evaluation, is described in detail. (CLB)

  18. Organising purchasing and (strategic) sourcing

    DEFF Research Database (Denmark)

    Lidegaard, Nina; Boer, Harry; Munkgaard Møller, Morten

    2015-01-01

    or hybrid overall structure, deliver the expected results. Contingency theory predicts that the success of a firm depends on the fit among characteristics of, amongst others, the firm’s processes and organisational structure. The objective of this paper is to propose and illustrate a processbased...... typological theory of purchasing and (strategic) sourcing organisation....

  19. Strategic Groups and Banks’ Performance

    Directory of Open Access Journals (Sweden)

    Gregorz Halaj

    2009-06-01

    Full Text Available The theory of strategic groups predicts the existence of stable groups of companies that adopt similar business strategies. The theory also predicts that groups will differ in performance and in their reaction to external shocks. We use cluster analysis to identify strategic groups in the Polish banking sector. We find stable groups in the Polish banking sector constituted after the year 2000 following the major privatisation and ownership changes connected with transition to the mostly-privately-owned banking sector in the late 90s. Using panel regression methods we show that the allocation of banks to groups is statistically significant in explaining the profitability of banks. Thus, breaking down the banks into strategic groups and allowing for the different reaction of the groups to external shocks helps in a more accurate explanation of profits of the banking sector as a whole.Therefore, a more precise ex ante assessment of the loss absorption capabilities of banks is possible, which is crucial for an analysis of banking sector stability. However, we did not find evidence of the usefulness of strategic groups in explaining the quality of bank portfolios as measured by irregular loans over total loans, which is a more direct way to assess risks to financial stability.

  20. IT Strategic and Operational Controls

    CERN Document Server

    Kyriazoglou, J

    2010-01-01

    This book provides a comprehensive guide to implementing an integrated and flexible set of IT controls in a systematic way. It can help organisations to formulate a complete culture for all areas which must be supervised and controlled; allowing them to simultaneously ensure a secure, high standard whilst striving to obtain the strategic and operational goals of the company.

  1. TFV as a strategic tool

    DEFF Research Database (Denmark)

    Bonke, Sten; Bertelsen, Sven

    2011-01-01

    The paper investigates the use of the Transformation-Flow-Value theory as a strategic tool in the development of the project production firm. When producing products such as ships, focus on value more than on cost may be the best approach, but in service industries such as construction, focus...

  2. Strategic School Planning in Jordan

    Science.gov (United States)

    Al-Zboon, Mohammad Saleem; Hasan, Manal Subhi

    2012-01-01

    The study aimed to measuring the applying degree of the strategic school planning stages at the Governmental high schools from the educational supervisors and principals perspective in the directorates related to Amman city, the study society was formed of the educational supervisors and principals working at Educational directorates related to…

  3. Strategic Approaches with Resistant Families.

    Science.gov (United States)

    Breit, Miranda; And Others

    1983-01-01

    Describes the operation of a 10-session brief therapy unit for families who have failed in more traditional treatment modalities. Case material is presented to exemplify five different treatment strategies: symptom prescription, reframing, illusion of alternatives, role play, and strategic alliances. Advantages and limitations are discussed.…

  4. Strategic Audit and Marketing Plan

    Science.gov (United States)

    Wright, Lianna S.

    2013-01-01

    The purpose of this audit was to revise the marketing plan for ADSum Professional Development School and give the owner a long-term vision of the school to operate competitively in the crowded field of for-profit schools. It is fairly simple to create a strategic plan but harder to implement and execute. Execution requires weeks and months of…

  5. Negotiation for Strategic Video Games

    OpenAIRE

    Afiouni, Einar Nour; Ovrelid, Leif Julian

    2013-01-01

    This project aims to examine the possibilities of using game theoretic concepts and multi-agent systems in modern video games with real time demands. We have implemented a multi-issue negotiation system for the strategic video game Civilization IV, evaluating different negotiation techniques with a focus on the use of opponent modeling to improve negotiation results.

  6. Strategic Planning for School Success.

    Science.gov (United States)

    Herman, Jerry J.

    1993-01-01

    Strategic planners concerned with such matters as high-achieving students, high-performing teachers, broad-based community support, and a two-way involvement with the community must analyze the strengths, weaknesses, opportunities, and threats existing in the school's internal and external environment. A sample SWOT analysis is included. (MLH)

  7. Rewarding Stakeholders: The Perspective of Strategic Entrepreneurship

    OpenAIRE

    Dissanayake, Srinath

    2013-01-01

    Prime concern on stakeholders is a crucial aspect in each business success. Among the wide spectrum of organizational strategies, Strategic Entrepreneurship pays a greater emphasis. This essay details practical as well as empirical grounds with regard to the notion of Strategic Entrepreneurship. Focally, strategic Entrepreneurship is an integration of Entrepreneurship (Opportunity Seeking Behavior) and Strategic Management (Advantage Seeking Behavior). Thus I conclude, an amalgamation of Str...

  8. Strategic Interaction, Competition, Cooperation and Observability

    OpenAIRE

    Groh, Christian

    2001-01-01

    Both the Cournot and the Bertrand oligopoly model make an important distinction between buyers and sellers. Sellers act as strategic players and are able to influence prices, buyers act non-strategically and are just represented by a demand function. This dissertation looks at situations without distinctions between buyers and sellers. Chapter two analyzes strategic market games à la Shapley and Shubik (Journal of Political Economy, 1977) with sequential moves. Usually, strategic market games...

  9. Maturity of strategic management in organizations

    OpenAIRE

    Anna Witek-Crabb

    2015-01-01

    There is some ambivalence with regards to how to improve strategic management of organizations. On the one hand the example of big companies emphasizes the need for formalization and good organization of strategic management process. On the other hand the example of small companies draws attention to such qualities as entrepreneurship, flexibility and adaptability. The concept of strategic management maturity embraces both of these priorities. In this paper a framework for strategic managemen...

  10. Information System of Scenario Strategic Planning

    OpenAIRE

    Denis, R.; Maxim, P.; Sergei, M.

    2009-01-01

    This paper gives an overview of the concept of a new system to support decision-making process in the area of strategic management company DEM. To ensure that in the modern world the company remains leader in its industry it needs to continually adjust its development strategy to changes. Nevertheless, there is no unified methodological framework for strategic planning. Also there are no strategic planning systems to help managers make strategic decisions (a problem of choice of the one of th...

  11. 75 FR 15686 - NOAA'S Office of Ocean Exploration and Research (OER) Strategic Plan FY 2011-FY 2015

    Science.gov (United States)

    2010-03-30

    ... National Oceanic and Atmospheric Administration NOAA'S Office of Ocean Exploration and Research (OER) Strategic Plan FY 2011-FY 2015 AGENCY: Office of Ocean Exploration and Research (OER), Oceanic and... Research (OER) is seeking comments on the draft OER STRATEGIC PLAN Fiscal Year (FY) 2011- 2015,...

  12. Long Range and Strategic Planning for Urban Managers, Modules 1-8, Package III. Participant Manual; Instruction Guide.

    Science.gov (United States)

    Freund, Eva

    This package contains the instructor and participant manuals for eight modules which comprise a portion of the National Training and Development Service Urban Management Curriculum Development Project. These modules focus on long range strategic planning. The specific modules are: (1) Strategic Planning; (2) Situation Analysis; (3) Setting…

  13. SUBTASK 6.1 – STRATEGIC STUDIES

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, Thomas; Harju, John; Steadman, Edward; Holmes, Michael

    2015-05-31

    The Energy & Environmental Research Center (EERC) has recently completed 7 years of research through the Cooperative Agreement with the U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL) focused on fossil energy technology development and demonstration. To support a significant number of the different activities being considered within all of our research contracts with NETL, a subtask (6.1 – Strategic Studies) was created to focus on small research efforts that came up throughout the year that would support an existing EERC–NETL project or would help to develop a new concept for inclusion in future efforts. This subtask was funded through the EERC–DOE Joint Program on Research and Development for Fossil Energy-Related Resources Cooperative Agreement No. DE-FC26- 08NT43291

  14. Vision 21: The NASA strategic plan

    Science.gov (United States)

    1992-01-01

    The NASA Strategic Plan, Vision 21, is a living roadmap to the future to guide the men and women of the NASA team as they ensure U.S. leadership in space exploration and aeronautics research. This multiyear plan consists of a set of programs and activities that will retain our leadership in space science and the exploration of the solar system; help rebuild our nation's technology base and strengthen our leadership in aviation and other key industries; encourage commercial applications of space technology; use the unique perspective of space to better understand our home planet; provide the U.S. and its partners with a permanent space based research facility; expand on the legacy of Apollo and initiate precursor activities to establish a lunar base; and allow us a journey into tomorrow, journey to another planet (Mars), and beyond.

  15. Characteristics of Useful and Practical Organizational Strategic Plans

    Science.gov (United States)

    Kaufman, Roger

    2014-01-01

    Most organizational strategic plans are not strategic but rather tactical or operational plans masquerading as "strategic." This article identifies the basic elements required in a useful and practical strategic plan and explains why they are important.

  16. Strategic Alliance Poker: Demonstrating the Importance of Complementary Resources and Trust in Strategic Alliance Management

    Science.gov (United States)

    Reutzel, Christopher R.; Worthington, William J.; Collins, Jamie D.

    2012-01-01

    Strategic Alliance Poker (SAP) provides instructors with an opportunity to integrate the resource based view with their discussion of strategic alliances in undergraduate Strategic Management courses. Specifically, SAP provides Strategic Management instructors with an experiential exercise that can be used to illustrate the value creation…

  17. Antiviral resistance and the control of pandemic influenza: The roles of stochasticity, evolution and model details

    OpenAIRE

    Handel, Andreas; Longini, Ira M.; Antia, Rustom

    2008-01-01

    Antiviral drugs, most notably the neuraminidase inhibitors, are an important component of control strategies aimed to prevent or limit any future influenza pandemic. The potential large-scale use of antiviral drugs brings with it the danger of drug resistance evolution. A number of recent studies have shown that the emergence of drug-resistant influenza could undermine the usefulness of antiviral drugs for the control of an epidemic or pandemic outbreak. While these studies have provided impo...

  18. Engineered Mammalian RNAi Can Elicit Antiviral Protection that Negates the Requirement for the Interferon Response

    OpenAIRE

    Asiel Arturo Benitez; Laura Adrienne Spanko; Mehdi Bouhaddou; David Sachs; Benjamin Robert tenOever

    2015-01-01

    While the intrinsic antiviral cell defenses of many kingdoms utilize pathogen-specific small RNAs, the antiviral response of chordates is primarily protein-based and not uniquely tailored to the incoming microbe. In an effort to explain this evolutionary bifurcation, we determined whether antiviral RNA interference (RNAi) was sufficient to replace the protein-based type I interferon (IFN-I) system of mammals. To this end, we recreated an RNAi-like response in mammals and determined its effect...

  19. The use of antiviral drugs for influenza: Guidance for practitioners, 2012/2013; Paediatric summary

    OpenAIRE

    Allen, Upton D.

    2013-01-01

    This practice point summarizes the use of antiviral drugs to manage influenza illness in children and youth for the 2012/2013 season. It excerpts a recently published, full-length update of Canadian recommendations for clinicians on the use of antiviral drugs for the prevention and treatment of influenza, with a focus on paediatric antiviral therapy. Detailed information on the selective use of chemoprophylaxis can be found in the source document, which also highlights the importance of secon...

  20. Using the Ferret as an Animal Model for Investigating Influenza Antiviral Effectiveness

    OpenAIRE

    Oh, Ding Y.; Hurt, Aeron C.

    2016-01-01

    The concern of the emergence of a pandemic influenza virus has sparked an increased effort toward the development and testing of novel influenza antivirals. Central to this is the animal model of influenza infection, which has played an important role in understanding treatment effectiveness and the effect of antivirals on host immune responses. Among the different animal models of influenza, ferrets can be considered the most suitable for antiviral studies as they display most of the human-l...

  1. Strategic Activism, Educational Leadership and Social Justice

    Science.gov (United States)

    Ryan, James

    2016-01-01

    This article describes the strategic activism of educational leaders who promote social justice. Given the risks, educational leaders need to be strategic about the ways in which they pursue their activism. Citing current research, this article explores the ways in which leaders strategically pursue their social justice agendas within their own…

  2. Rethinking Strategy and Strategic Leadership in Schools.

    Science.gov (United States)

    Davies, Brent

    2003-01-01

    Reviews nature of strategy and strategic leadership in schools. Considers how leaders can map and reconceptualize the nature of strategy and develop strategic capabilities for longer-term sustainability. Questions hierarchical models of leadership. Highlights three characteristics of strategically oriented schools; suggests ways to improve art of…

  3. 12 CFR 563e.27 - Strategic plan.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Strategic plan. 563e.27 Section 563e.27 Banks... for Assessing Performance § 563e.27 Strategic plan. (a) Alternative election. The OTS will assess a... strategic plan if: (1) The savings association has submitted the plan to the OTS as provided for in...

  4. 12 CFR 228.27 - Strategic plan.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Strategic plan. 228.27 Section 228.27 Banks and... REINVESTMENT (REGULATION BB) Standards for Assessing Performance § 228.27 Strategic plan. (a) Alternative...(s) under a strategic plan if: (1) The bank has submitted the plan to the Board as provided for...

  5. Strategic Management in Chinese Manufacturing SMEs

    OpenAIRE

    Chen, Muxia; Bowen, Liu

    2012-01-01

    This study is about to find out whether and how strategic management is employed in the Chinese manufacturing SMEs, as well as to explore the main characteristics of the strategic management process in these SMEs. It aims to work as a reference for the senior managers in these firms to better improve and utilize the strategic management tools for their future growth.

  6. 13 CFR 313.6 - Strategic Plans.

    Science.gov (United States)

    2010-01-01

    .... EDA shall evaluate the Strategic Plan based on the following minimum requirements: (1) An analysis of... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Strategic Plans. 313.6 Section 313... § 313.6 Strategic Plans. (a) General. An Impacted Community that intends to apply for a grant...

  7. Strategic decision quality in Flemish municipalities

    NARCIS (Netherlands)

    B.R.J. George (Bert); S. Desmidt (Sebastian); J. De Moyer (Julie)

    2016-01-01

    textabstractStrategic planning (SP) has taken the public sector by storm because it is widely believed that SP’s approach to strategic decision-making strengthens strategic decision quality (SDQ) in public organizations. However, if or how SP relates to SDQ seems to lack empirical evidence. Drawing

  8. Collaborative Strategic Planning: Myth or Reality?

    Science.gov (United States)

    Mbugua, Flora; Rarieya, Jane F. A.

    2014-01-01

    The concept and practice of strategic planning, while entrenched in educational institutions in the West, is just catching on in Kenya. While literature emphasizes the importance of collaborative strategic planning, it does not indicate the challenges presented by collaboratively engaging in strategic planning. This article reports on findings of…

  9. The value contribution of strategic foresight

    DEFF Research Database (Denmark)

    Rohrbeck, René; Schwarz, Jan Oliver

    2013-01-01

    This paper focuses on exploring the potential and empirically observable value creation of strategic foresight activities in firms. We first review the literature on strategic foresight, innovation management and strategic management in order to identify the potential value contributions. We use...

  10. Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes

    Directory of Open Access Journals (Sweden)

    Yu D

    2016-01-01

    Full Text Available Debin Yu,1 Mingzhi Zhao,2 Liwei Dong,1 Lu Zhao,1 Mingwei Zou,3 Hetong Sun,4 Mengying Zhang,4 Hongyu Liu,4 Zhihua Zou1 1National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Sciences, Jilin University, Changchun, 2State Key Laboratory of Proteomics, National Engineering Research Center for Protein Drugs, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, People’s Republic of China; 3Department of Psychology, College of Liberal Arts and Social Sciences, University of Houston, Houston, TX, USA; 4Prosit Sole Biotechnology, Co., Ltd., Beijing, People’s Republic of China Abstract: Type III interferons (IFNs (also called IFN-λ: IFN-λ1, IFN-λ2, IFN-λ3, and IFN-λ4 are critical players in the defense against viral infection of mucosal epithelial cells, where the activity of type I IFNs is weak, and unlike type I IFNs that are associated with severe and diverse side effects, type III IFNs cause minimal side effects due to the highly restricted expression of their receptors, and thus appear to be promising agents for the treatment and prevention of respiratory and gastrointestinal viral infection. However, the antiviral potency of natural type III IFNs is weak compared to type I and, although IFN-λ3 possesses the highest bioactivity among the type III IFNs, IFN-λ1, instead of IFN-λ3, is being developed as a therapeutic drug due to the difficulty to express IFN-λ3 in the prokaryotic expression system. Here, to develop optimal IFN-λ molecules with improved drug attributes, we designed a series of IFN-λ analogs by replacing critical amino acids of IFN-λ1 with the IFN-λ3 counterparts, and vice versa. Four of the designed analogs were successfully expressed in Escherichia coli with high yield and were easily purified from inclusion bodies. Interestingly, all four analogs showed potent activity in inducing the

  11. Epidemiological Characteristics of Novel Influenza A (H1N1) in Antiviral Drug Users in Korea

    OpenAIRE

    Kyunghi Choi; Sung-il Cho; Masahiro Hashizume; Ho Kim

    2012-01-01

    Soon after the first novel influenza A (H1N1) death was documented in Korea on August 15, 2009, prompt treatment with antiviral drugs was recommended when an infection was suspected. Free antiviral drugs were distributed to patients who met the case definition in the treatment guidelines, and patients prescribed the antiviral drugs were included in the Antiviral Drug Surveillance System (ADSS). A total of 2,825,821 patients were reported to the ADSS from September 1 to December 31, 2009. Odds...

  12. In vitro comparison of antiviral drugs against feline herpesvirus 1

    Directory of Open Access Journals (Sweden)

    Garré B

    2006-04-01

    Full Text Available Abstract Background Feline herpesvirus 1 (FHV-1 is a common cause of respiratory and ocular disease in cats. Especially in young kittens that have not yet reached the age of vaccination, but already lost maternal immunity, severe disease may occur. Therefore, there is a need for an effective antiviral treatment. In the present study, the efficacy of six antiviral drugs, i.e. acyclovir, ganciclovir, cidofovir, foscarnet, adefovir and 9-(2-phosphonylmethoxyethyl-2, 6-diaminopurine (PMEDAP, against FHV-1 was compared in Crandell-Rees feline kidney (CRFK cells using reduction in plaque number and plaque size as parameters. Results The capacity to reduce the number of plaques was most pronounced for ganciclovir, PMEDAP and cidofovir. IC50 (NUMBER values were 3.2 μg/ml (12.5 μM, 4.8 μg/ml (14.3 μM and 6 μg/ml (21.5 μM, respectively. Adefovir and foscarnet were intermediately efficient with an IC50 (NUMBER of 20 μg/ml (73.2 μM and 27 μg/ml (140.6 μM, respectively. Acyclovir was least efficient (IC50 (NUMBER of 56 μg/ml or 248.7 μM. All antiviral drugs were able to significantly reduce plaque size when compared with the untreated control. As observed for the reduction in plaque number, ganciclovir, PMEDAP and cidofovir were most potent in reducing plaque size. IC50 (SIZE values were 0.4 μg/ml (1.7 μM, 0.9 μg/ml (2.7 μM and 0.2 μg/ml (0.7 μM, respectively. Adefovir and foscarnet were intermediately potent, with an IC50 (SIZE of 4 μg/ml (14.6 μM and 7 μg/ml (36.4 μM, respectively. Acyclovir was least potent (IC50 (SIZE of 15 μg/ml or 66.6 μM. The results demonstrate that the IC50 (SIZE values were notably lower than the IC50 (NUMBER values. The most remarkable effect was observed for cidofovir and ganciclovir. None of the products were toxic for CRFK cells at antiviral concentrations. Conclusion In conclusion, measuring reduction in plaque number and plaque size are two valuable and complementary means of assessing the efficacy of

  13. Peran Strategic Entrepreneurship dalam membangun Sustainable Competitive Advantage

    OpenAIRE

    Agustinus Dedy Handrimurtjahjo

    2014-01-01

    Strategic entrepreneurship has emerged as a new concept in examining convergence in entrepreneurship studies (opportunity-seeking behavior) and strategic management (advantage-seeking behavior). Studies in the area of strategic management have gradually exposed the relationship between strategic management and entrepreneurship: entrepreneurial strategy making; intrapreneurship; entrepreneurial strategic posture within organizations; entrepreneurial orientation; strategic management integratio...

  14. ABOUT ABRASION RESISTANCE OF FABRICS WITH STRATEGIC DESTINATION PART I

    OpenAIRE

    Adina Bucevschi; Alexandru Popa; Monica Pustianu; Erzsebet Airinei; Ionel Barbu

    2011-01-01

    This paper is part of a research agreement between "Aurel Vlaicu" University and The NationalResearch - Development Institute for Textile and Leather, Bucharest, about the relationship of interdependencebetween the yarns' characteristics and fabric's characteristics for the installation of ventilation and heating pipesof the military helicopter[5]. Fabrics for strategic areas must have certain characteristics such resistance at hightemperatures, breaking and tearing strength, shock resistance...

  15. ABOUT ABRASION RESISTANCE OF FABRICS WITH STRATEGIC DESTINATION PART II

    OpenAIRE

    Adina Bucevschi; Alexandru Popa; Monica Pustianu; Erzsebet Airinei; Ionel Barbu

    2011-01-01

    This paper is part of a research agreement between "Aurel Vlaicu" University and The National Research - Development Institute for Textile and Leather, Bucharest, about the relationship of interdependence between the yarns' characteristics and fabric's characteristics for the installation of ventilation and heating pipesof the military helicopter[5]. Fabrics for strategic areas must have certain characteristics such resistance at high temperatures, breaking and tearing strength, shock resista...

  16. Ethiopia's Tourism Sector : Strategic Paths to Competitiveness and Job Creation

    OpenAIRE

    World Bank

    2012-01-01

    This study analyzes strategic intervention options that can inform the implementation process of Ethiopia s national tourism development policy in an effort to make the sector globally competitive. It also outlines the analytical foundations for technical assistance that will be provided to Ministry of Culture and Tourism (MoCT) by the World Bank-funded Ethiopian Sustainable Tourism Development Program (ESTDP). This study uses the world economic forum tourism and travel competitiveness index ...

  17. Issues in strategic thought: from Clausewitz to al-Qaida

    OpenAIRE

    Nomura, Ryan C.

    2012-01-01

    Approved for public release; distribution is unlimited. Ever since the quickening of social and technological change that began during the Napoleonic era, there have been many strategic debates inspired by those developments. Six are discussed in this thesis Jomini vs. Clausewitz How useful are principles of war Mahan vs. Mackinder Is either land or sea power inherently more valuable for achieving national aims Bernhardi vs. Bloch Did industrialization make war an impractical endeavor Douh...

  18. Population-wide emergence of antiviral resistance during pandemic influenza.

    Directory of Open Access Journals (Sweden)

    Seyed M Moghadas

    Full Text Available BACKGROUND: The emergence of neuraminidase inhibitor resistance has raised concerns about the prudent use of antiviral drugs in response to the next influenza pandemic. While resistant strains may initially emerge with compromised viral fitness, mutations that largely compensate for this impaired fitness can arise. Understanding the extent to which these mutations affect the spread of disease in the population can have important implications for developing pandemic plans. METHODOLOGY/PRINCIPAL FINDINGS: By employing a deterministic mathematical model, we investigate possible scenarios for the emergence of population-wide resistance in the presence of antiviral drugs. The results show that if the treatment level (the fraction of clinical infections which receives treatment is maintained constant during the course of the outbreak, there is an optimal level that minimizes the final size of the pandemic. However, aggressive treatment above the optimal level can substantially promote the spread of highly transmissible resistant mutants and increase the total number of infections. We demonstrate that resistant outbreaks can occur more readily when the spread of disease is further delayed by applying other curtailing measures, even if treatment levels are kept modest. However, by changing treatment levels over the course of the pandemic, it is possible to reduce the final size of the pandemic below the minimum achieved at the optimal constant level. This reduction can occur with low treatment levels during the early stages of the pandemic, followed by a sharp increase in drug-use before the virus becomes widely spread. CONCLUSIONS/SIGNIFICANCE: Our findings suggest that an adaptive antiviral strategy with conservative initial treatment levels, followed by a timely increase in the scale of drug-use, can minimize the final size of a pandemic while preventing large outbreaks of resistant infections.

  19. Effect of Antiviral Therapy on Hepatitis C Virus Related Glomerulopathy

    Directory of Open Access Journals (Sweden)

    Abbas Ghulam

    2008-01-01

    Full Text Available To determine the efficacy of antiviral therapy in hepatitis C virus associated glome-rulopathy, we studied 30 patients with HCV-associated glomerulopathy at Sheikh Zayed Hospital, Lahore, Pakistan from June 2004 to February 2007. Membranoproliferative glomerulonephritis (MPGN was the commonest kidney lesion, being reported in 25/30 (83%, followed by membra-nous glomerulonephritis (MGN in 3/30 (10% and mesangioproliferative glomerulonephritis (MesGN in 2/30 (7%. Cryoglobulinaemia was positive in 8/20 (40% cases. Most common HCV genotype was 3a. All the patients received interferon alpha combined with ribavirin therapy for 6-12 months based on viral genotypes and doses were adjusted according to renal function. Anti-viral response was achieved in the form of aviremia at completion of 6 months treatment in 8/30 (26.6%, decreased transaminases levels from a mean of 96.4 ± 72.2 to 60.1 ± 44.3 IU/L, p= 0.005, 24-hour proteinuria decreased significantly from a mean of 4.8 g to 1.20 g, p= 0.001, and complement C3 and C4 concentrations returned to normal in those subjects who responded to treatment. The rate of relapse was 50%. We conclude that though the overall antiviral response of HCV was not high, there was a significant reduction in proteinuria suggesting indirectly an improvement in renal patho-logy. Further studies with large number of patients with follow-up renal biopsies are warranted.

  20. "Strategic Reassurance" and the Future of China-U.S. Relations

    Institute of Scientific and Technical Information of China (English)

    Yuan Peng; Ma Zongshi

    2010-01-01

    "Strategic reassurance," a new concept in Obama's China policy, should be fostered bilaterally by dialogue designed to highlight and reinforce the areas of common interests while addressing the sources of mistrust directly. Yet in practice it seems that U.S. strategic reassurance has contrasted all China's core interests. The United States and China must recognize their different social systems and asymmetrical national strength in seeking to realize strategic stability. Crisis control requires sophisticated management of both side, especially on sensitive issues like weapons sales, the Dalai Lama, and the South China Sea dispute.