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Sample records for antipruritics

  1. GC法测定消炎止痒醑中薄荷脑的含量%Determination of Menthol in Anti-inflammatory Antipruritic Spiritus by GC

    Institute of Scientific and Technical Information of China (English)

    张咏梅; 陶宇

    2012-01-01

    Objective To establish a method for the determination of menthol in anti-inflammatory antipruritic spiritus by GC. Methods GC was performed on a CP-Sil 5 CB column (25m × 0.32mm × 0.4um) using FID as the detector. Inlet temperature was set at 250 ℃ and column temperature was 280 ℃ (temperature program: initial temperature 60 ℃, maintained lmin, then rise to 280 ℃ with the rate of 12 ℃ / min, maintained 3min); detector temperature was 300 ℃ ; split injection , split ratio 20:1; injection volume 1μL. Results The standard curve was linear in the range of 50.8 ~ 609.6mg / L, r = 0.999 69, the average recovery was 99.10% with RSD of 0.87% (n = 6). Conclusion The method was simple, fast, accurate, reproducible and could be used for the determination of menthol in anti-inflammatory antipruritic spiritus.%目的 建立GC法测定消炎止痒醑中薄荷脑的含量.方法 采用CP-Sil 5 CB色谱柱(25m×0.32mm×0.4μm),FID检测器.进样口温度250℃;柱温280℃(程序升温:初始温度60℃,保持1min,再以12℃/min的速度升至280℃,保持3min);检测器温度300℃;分流进样,分流比20:1;进样量1μL.结果 薄荷脑进样量在50.8 ~ 609.6mg/L范围内与峰面积呈良好线性关系,r=0.999 69,平均回收率为99.10%,RSD为0.87%(n=6).结论 本测定方法简便、快速、准确、重复性好,可作为消炎止痒醑的含量测定方法.

  2. Anti-inflammatory and antipruritic effects of Chushizhiyang ointment%除湿止痒软膏抗炎及止痒作用研究

    Institute of Scientific and Technical Information of China (English)

    曾怡; 史梦琪; 杨欢; 何萍; 王有为; 杜俊蓉

    2015-01-01

    目的:探讨除湿止痒软膏的抗炎及止痒作用。方法用2,4-二硝基氟苯(DNFB)腹部致敏和背部反复激发建立 BALB/c 小鼠特应性皮炎模型。实验动物分为正常对照组(未致敏也未治疗)、模型对照组(致敏但未治疗)、氢化可的松乳膏组(致敏+氢化可的松)、除湿止痒软膏组(致敏+除湿止痒软膏)。连续用药14 d,末次给药12 h 后取背部皮肤,测定皮肤厚度及质量,进行 HE 染色和甲苯胺蓝染色,ELISA 法检测皮损组织中干扰素(IFN)γ、肿瘤坏死因子(TNF)α、白细胞介素(IL)-4、IL-5含量。利用磷酸组胺诱发 Hartley 豚鼠局部皮肤瘙痒模型,观察除湿止痒软膏对豚鼠致痒阈的影响。结果用药后第15天,与模型对照组相比,氢化可的松乳膏和除湿止痒软膏均可明显减少小鼠的背部皮肤厚度和质量(P <0.01),减少淋巴细胞和肥大细胞浸润(P <0.01)以及降低皮损组织中 IFN-γ、TNF-α、IL-4及 IL-5水平(P <0.05或 P <0.01)。与正常对照组相比,氢化可的松乳膏组小鼠背部皮肤厚度和质量减小(P <0.01),除湿止痒软膏组无明显变化。此外,除湿止痒软膏也可显著提高豚鼠耐受磷酸组胺的致痒阈(P <0.01)。结论除湿止痒软膏可明显抑制 DNFB 引起的小鼠特应性皮炎,其抗炎机制可能与恢复体内 Th1/Th2型细胞因子平衡有关。除湿止痒软膏可明显减轻磷酸组胺所致豚鼠皮肤瘙痒反应。%Objective To explore the anti-inflammatory and antipruritic effects of Chushizhiyang ointment in a mouse model. Methods A total of 40 male 8-week-old BALB/c mice were included in this study, and randomly and equally divided into 4 groups. A mouse model of atopic dermatitis (AD)was established in three groups of mice by repeated application of 2,4-dinitroflurobenzene (DNFB)to shaved abdominal skin for sensitization and to shaved dorsal skin for

  3. 疤痕止痒软化膏对烧伤创面致痒介质影响的动物实验研究%Experimental study on effect of cicatrix antipruritic ointment on burn wounds itch mediators

    Institute of Scientific and Technical Information of China (English)

    易先锋; 卢根香; 宋春红; 钟伟湘; 童钟

    2012-01-01

    Objective To observe the effects of cicatrix antipruritic ointment on burn wounds itch mediators of the rabbit. Methods The contents of nerve endings, substance P, mast cell, histamine and serotonin of the rabbits burn wounds treated by cicatrix antipruritic ointment in different time were determined by using Cajal Pyridine silver staining, immunohistochemical techniques and the computer image processing technique, we finished the study. Detecting the. Results The differences of nerve endings and SP content between two groups at the different time periods of the bum wounds were insignificant(P > 0.01). The differences between two groups were significant (P <0.01). Conclusion There is a certain impact of Antipruritic ointment for cicatrix preparation on the rabbit burn wounds itch mediators. Early intervention of bum wounds early period for bum itching is a method can be considered.%目的 研究疤痕止痒软化中药膏剂对家兔烧伤创面致痒介质的影响.方法 通过Cajal吡啶银染法,免疫组织化学技术,计算机辅助图像分析技术检测使用疤痕止痒软化膏后家兔烧伤创面及创面愈合后不同时间组织神经末梢数量,(substanceP,SP)P物质,肥大细胞数目,组胺及5-羟色胺的多少.结果 家兔使用疤痕止痒膏在烧伤创面及烧伤愈合后的创面不同时间点上部分毁损皮肤的神经末梢整体结构及数量实验组与对照组比较差异性不大.用药后家兔深Ⅱ°烧伤创面及烧伤愈合后创面组织不同时间点中组织SP含量与对照组比较差异性不大大(P>0.01).用药后实验组脱颗粒的肥大细胞数目明显少于对照组(P<0.01).实验组的组织胺及5-色胺量与对照组比较有明显差异(P<0.01).结论 疤痕止痒软化膏对家兔烧伤创面致痒介质有一定的影响,从烧伤创面早期就开始用药物进行烧伤瘙痒的干预是一条可以考虑的方法.

  4. Observation of curative effect of oral particles medicine of spleen-strengthening and damp-removing concomitant with antiphlogistic and antipruritic lotion wet dressing in the treatment of eczema%健脾祛湿颗粒口服配合消炎止痒洗剂湿敷治疗湿疹的疗效观察

    Institute of Scientific and Technical Information of China (English)

    赖旻; 杨玉峰; 李志峰; 钟美连

    2014-01-01

    Objective To observe the curative effect of oral particles medicine of spleenstrengthening and damp-removing concomitant with antiphlogistic and antipruritic lotion wet dressing in the treatment of eczema.Methods 90 cases of eczema were randomly divided into treatment group and control group,45 cases in each group.Treatment group was given the treatment of self-made spleen-strengthening and damp-removing particles medicine,one dose a day,infused with warm water twice a day in the morning and night,and combined with antiphlogistic and antipruritic lotion:20 g powder soaked with 2000 ml warm water for 20 min,after cooling to room temperature,5-6 layers of gauze dipped in the liquid for a moment,when the gauze didn' t drip wetted the affected area about 20 minutes,2-3 times a day.Control group was given the treatment of topical mupirocin ointment combined mometasone furoate cream.The treatment lasted for 30 days.Observed scores of pruritus,rash form,rash area and total score in two groups before and after the treatment,at the same time compared the clinical efficacy and adverse reactions occurred during the treatment.Results After treatment,scores of rash form and rash area in treatment group were lower than those in control group,with statistically significant differences (P < 0.05 or P < 0.01); pruritus score in treatment group was higher than that in control group,with statistically significant difference (P < 0.05); there was no statisticallysignificant difference in total score between two groups (P > 0.05).The total effective rate in treatment group was 86.7%,while that in control group was 77.7%,without statistically significant difference (u =-1.590,P > 0.05).There were 3 cases of skin burning sensation and pigmentation in treatment group,8 cases in control group.Conclusions Oral particles medicine of spleen-strengthening and damp-removing concomitant with antiphlogistic and antipruritic lotion wet dressing in the treatment of eczema had the same

  5. Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.

    Science.gov (United States)

    Gupta, Achla; Gomes, Ivone; Bobeck, Erin N; Fakira, Amanda K; Massaro, Nicholas P; Sharma, Indrajeet; Cavé, Adrien; Hamm, Heidi E; Parello, Joseph; Devi, Lakshmi A

    2016-05-24

    Among the opioid receptors, the κ-opioid receptor (κOR) has been gaining considerable attention as a potential therapeutic target for the treatment of complex CNS disorders including depression, visceral pain, and cocaine addiction. With an interest in discovering novel ligands targeting κOR, we searched natural products for unusual scaffolds and identified collybolide (Colly), a nonnitrogenous sesquiterpene from the mushroom Collybia maculata. This compound has a furyl-δ-lactone core similar to that of Salvinorin A (Sal A), another natural product from the plant Salvia divinorum Characterization of the molecular pharmacological properties reveals that Colly, like Sal A, is a highly potent and selective κOR agonist. However, the two compounds differ in certain signaling and behavioral properties. Colly exhibits 10- to 50-fold higher potency in activating the mitogen-activated protein kinase pathway compared with Sal A. Taken with the fact that the two compounds are equipotent for inhibiting adenylyl cyclase activity, these results suggest that Colly behaves as a biased agonist of κOR. Behavioral studies also support the biased agonistic activity of Colly in that it exhibits ∼10-fold higher potency in blocking non-histamine-mediated itch compared with Sal A, and this difference is not seen in pain attenuation by these two compounds. These results represent a rare example of functional selectivity by two natural products that act on the same receptor. The biased agonistic activity, along with an easily modifiable structure compared with Sal A, makes Colly an ideal candidate for the development of novel therapeutics targeting κOR with reduced side effects. PMID:27162327

  6. Observations on the use of cyproheptadine hydrochloride as an antipruritic agent in allergic cats.

    OpenAIRE

    Scott, D W; Rothstein, E; Beningo, K E; Miller, W. H.

    1998-01-01

    Cyproheptadine hydrochloride was administered to 20 presumed or proven allergic cats to determine its efficacy in controlling pruritus. Each cat received 2 mg, orally, every 12 h. The pruritus was satisfactorily controlled in 9 cats. Side effects were seen in 8 cats, and included polyphagia, sedation, vocalization, affectionate behavior, and vomiting.

  7. Double-blinded, placebo-controlled study to evaluate an antipruritic shampoo for dogs with allergic pruritus.

    Science.gov (United States)

    Schilling, J; Mueller, R S

    2012-07-28

    Shampoo therapy is frequently used on pruritic dogs. However, there are few double-blinded, placebo-controlled studies of this form of therapy. This randomised, double-blinded, placebo-controlled study evaluated the efficacy of a commercial medicated shampoo (DermaTopic; Almapharm) containing chlorhexidine, lactoferrin, piroctone olamine, chitosan and essential fatty acids in 27 dogs with mild to moderate allergic pruritus without secondary skin infections. All dogs received shampoo therapy with either DermaTopic or a shampoo vehicle as placebo twice weekly for four weeks. The extent of pruritus was evaluated before the study and then on a daily basis by the owners using a visual analogue scale. Before beginning the treatment and after four weeks, the skin lesions were evaluated by an experienced clinician with a validated lesion score (Canine Atopic Dermatitis Extent and Severity Index - CADESI). The pruritus was reduced significantly by both DermaTopic and placebo. However, there was no significant difference between both groups. There was no statistically significant difference in the CADESI scores pre- and post-treatment in either group or between the two types of treatment. This study provides further evidence of the benefit of shampoo therapy for pruritic dogs.

  8. Double-blinded, placebo-controlled study to evaluate an antipruritic shampoo for dogs with allergic pruritus.

    Science.gov (United States)

    Schilling, J; Mueller, R S

    2012-07-28

    Shampoo therapy is frequently used on pruritic dogs. However, there are few double-blinded, placebo-controlled studies of this form of therapy. This randomised, double-blinded, placebo-controlled study evaluated the efficacy of a commercial medicated shampoo (DermaTopic; Almapharm) containing chlorhexidine, lactoferrin, piroctone olamine, chitosan and essential fatty acids in 27 dogs with mild to moderate allergic pruritus without secondary skin infections. All dogs received shampoo therapy with either DermaTopic or a shampoo vehicle as placebo twice weekly for four weeks. The extent of pruritus was evaluated before the study and then on a daily basis by the owners using a visual analogue scale. Before beginning the treatment and after four weeks, the skin lesions were evaluated by an experienced clinician with a validated lesion score (Canine Atopic Dermatitis Extent and Severity Index - CADESI). The pruritus was reduced significantly by both DermaTopic and placebo. However, there was no significant difference between both groups. There was no statistically significant difference in the CADESI scores pre- and post-treatment in either group or between the two types of treatment. This study provides further evidence of the benefit of shampoo therapy for pruritic dogs. PMID:22678620

  9. Antipruritic effect of cold-induced and transient receptor potential-agonist-induced counter-irritation on histaminergic itch in humans

    DEFF Research Database (Denmark)

    Andersen, Hjalte H.; Melholt, Camilla; Hilborg, Sigurd D.;

    2016-01-01

    (trans-cinnamaldehyde/L-menthol, respectively), on histamine-induced itch, wheal and neurogenic inflammation in 13 healthy volunteers. Histamine 1% was applied to the volar forearms using skin prick-testing lancets. Recorded outcome-parameters were itch intensity, wheal reactions and neurogenic...... inflammation (measured by laser-speckle perfusion-imaging). Homotopic thermal counter-irritation was performed with 6 temperatures, ranging from 4°C to 37°C, using a 3 × 3-cm thermal stimulator. Chemical "cold-like" counter-irritation was conducted with 40% L-menthol and 10% trans-cinnamaldehyde, while 5...

  10. A comparison of dexamethasone, ondansetron, and dexamethasone plus ondansetron as prophylactic antiemetic and antipruritic therapy in patients receiving intrathecal morphine for major orthopedic surgery.

    LENUS (Irish Health Repository)

    Szarvas, Szilvia

    2012-02-03

    In a prospective, double-blinded, randomized trial, we evaluated the efficacy of IV (a) dexamethasone 8 mg, (b) ondansetron 8 mg, and (c) dexamethasone 8 mg plus ondansetron 4 mg for the prevention of postoperative nausea, vomiting (PONV), and pruritus in 130 (ASA physical status I to III) patients undergoing elective major orthopedic surgery after spinal anesthesia with hyperbaric 0.5% bupivacaine and intrathecal morphine. After spinal anesthesia, patients were randomized to one of three groups. Failure of PONV prophylaxis in the 24-h postoperative period occurred more frequently in patients who received dexamethasone alone (29 of 40; 73%) compared with those who received either ondansetron alone (23 of 47; 49%) (P = 0.02) or dexamethasone plus ondansetron together (19 of 43; 44%)(P = 0.01). There was no difference in the incidence of failure of prophylaxis of pruritus (70%, 72%, and 70% in dexamethasone 8 mg, ondansetron 8 mg, and dexamethasone 8 mg plus ondansetron 4 mg, respectively) (P > 0.1) in the 24-h postoperative period. We conclude that the administration of dexamethasone 8 mg with ondansetron 4 mg has no added benefit compared with ondansetron 8 mg alone in the prophylaxis of PONV and pruritus. IMPLICATIONS: Postoperative nausea and vomiting (PONV) and pruritus are common side effects after spinal opioid administration. In this study, dexamethasone 8 mg plus ondansetron 4 mg was as effective as ondansetron 8 mg. The administration of dexamethasone alone was associated with a frequent incidence of PONV, demonstrating a lack of efficacy. This has important cost implications.

  11. Antipruritic Mechanisms of Pimecrolimus Cream for Facial Dermatitis in Adult Women Patients%吡美莫司乳膏对成年女性面部皮炎快速抗瘙痒机制

    Institute of Scientific and Technical Information of China (English)

    谢志强; 杨高云; 姜薇; 徐敏丽

    2009-01-01

    目的 探讨吡美莫司乳膏对成年女性面部皮炎快速抗瘙痒机制.方法 采用研究者总体评估(IGA)、瘙痒程度(SP)评分及参照由温度敏感瞬时受体电位通道建立的痛痒觉基本规则和分子底物方法,评估外用1%吡美莫司乳膏治疗前、后成年女性患者面部皮炎临床体征、SP及皮肤感觉变化.结果 所有患者治疗后第4天和第11天的IGA评分,治疗后第1天、第4天和第11天的SP评分均显著低于治疗前(P均<0.05).52例患者中.有28例(53.8%)在用药数分钟后出现辣椒素样效应,12例(23.1%)出现樟脑样效应,12例(23.1%)未出现辣椒素样效应或樟脑样效应.结论 外用吡美莫司可迅速缓解成年女性面部皮炎的症状和体征,其可能是通过激活皮肤感觉神经上的瞬时受体电位香草类受体1诱导辣椒素样效应或樟脑样效应来达到快速抗瘙痒作用.

  12. Antipruritic and anti-inflammatory effect of Tianranshiyang Cream on experimental contact dermatitis in mice%天然湿痒霜对小鼠实验性皮炎的抗炎止痒作用研究

    Institute of Scientific and Technical Information of China (English)

    李宁; 曹波; 高颖; 李覃; 张永亮; 李玉明; 陈虹

    2014-01-01

    [目的]研究天然湿痒霜对小鼠实验性皮炎的抗炎止痒作用.[方法]采用二甲苯致小鼠耳肿胀模型,检测天然湿痒霜对小鼠耳肿胀度的影响;采用氨基吡啶诱发小鼠致痒模型,检测天然湿痒霜对小鼠皮肤瘙痒反应的影响.[结果]天然湿痒霜能显著抑制二甲苯所致的小鼠耳肿胀,高、中、低剂量组抑制率分别为33.1%、27.8%、21.4%.天然湿痒霜可显著缓解氨基吡啶诱发小鼠瘙痒,高、中、低剂量组缓解率分别为62.5%、59.4%、18.8%.[结论]天然湿痒霜体外具有显著的止痒和抗炎作用.

  13. Dyclonine content in the compound dyclonine menthol antipruritic emollients water with HPLC%HPLC测定复方达克罗宁薄荷脑润肤止痒水中达克罗宁的含量

    Institute of Scientific and Technical Information of China (English)

    李成; 颜晗; 罗意文; 曾繁涛; 路伟; 陈连剑

    2010-01-01

    目的 建立复方达克罗宁薄荷脑润肤止痒水中达克罗宁的含量测定方法 .方法 采用高效液相色谱法,色谱柱为Phenomenex lune(4.6 mm ×250 mm,5 μm),流动相为乙睛-水-三乙胺-冰醋酸(55:43.5:1.0:0.5),流速为0.5 ml/min,检测波长为279 nm,柱温30℃.结果 盐酸达克罗宁的检测线性范围为20.13-120.78 μg/ml,r=0.9995,平均回收率为99.6%,RSD为0.43%(n=6).结论 本法简便、准确、灵敏度高、重复性好,可作为复方达克罗宁薄荷脑润肤止痒水中达克罗宁的含量测定方法 .

  14. 消炎止痒洗剂合并复方当归薄荷膏治疗血液透析患者合并皮肤瘙痒的临床观察%Clinical observation of antiphlogistic and antipruritic lotion combined with Compound Angelica Mentholatum in hemodialysis patients with pruritus

    Institute of Scientific and Technical Information of China (English)

    安海文; 李燕林; 黄琳; 李锦山; 庞捷

    2016-01-01

    Objective To investigate the combination therapy effects of anti - inflammatory and itching lotion and compound angelica mint cream on uremic pruritus( UP). Method 80 cases of UP patients with hematodialysis treatment were randomly divided into two groups,the control group(38 patients)and the treatment group(42 patients),and treatment group’s patients were administrated with anti- inflammatory and itching lotion and compound angelica mint cream;meanwhile,the control group’s patients were administrated with warm water washing. Itching index were recorded before and after the treatment. Results The therapy effects on the treatment group were signifi-cantly better than the control group,the difference was statistically significant(P ﹤ 0. 01). Conclusion The combination therapy of anti -inflammatory and itching lotion and compound angelica mint cream is a effective method for UP curing,which is deserved to generalized in clinical.%目的:探讨消炎止痒洗剂合并复方当归薄荷膏治疗血液透析患者皮肤瘙痒的临床疗效。方法:将80例进行血液透析治疗的皮肤瘙痒症患者随机分为对照组38例和观察组42例,观察组的患者给予消炎止痒洗剂盆浴结合复方当归薄荷膏外涂治疗,对照组患者采用温水浴后使用橄榄油外涂,通过对瘙痒指数评分比较两组的临床疗效。结果:治疗组患者的临床疗效较对照组更好,差异有统计学意义(P ﹤0.01)。结论:消炎止痒洗剂合并复方当归薄荷膏可显著改善血液透析患者的皮肤瘙痒症状。

  15. Experimental research of compound xylocaine cream on anti-inflammatory, analgesic, anti-allergic and anti-pruritic effects%复方利多卡因乳膏的抗炎镇痛和抗过敏止痒的实验观察

    Institute of Scientific and Technical Information of China (English)

    盛国荣

    2010-01-01

    目的:研究复方利多卡因乳膏的抗炎镇痛和抗敏止痒的作用,为该药的临床研究提供依据.方法:采用小鼠耳廓肿胀法、小鼠热板法、大鼠同种被动皮肤过敏反应法、磷酸组胺致痒法等模型和方法,观察不同剂量的复方利多卡因乳膏对实验性动物的抗炎作用、镇痛作用、抗过敏作用和止痒作用的效果.结果:复方利多卡因乳膏能有效地抑制二甲苯引起的小鼠耳廓的炎症肿胀,能显著提高热板试验小鼠的痛阈,能不同程度地抑制抗血清诱发的大鼠同种被动皮肤过敏反应,能明显增加豚鼠耐受磷酸组胺的致痒阈,并均呈现良好的量效依赖关系.结论:复方利多卡因乳膏具有抗炎、镇痛、抗过敏和止痒作用,为临床应用提供了实验依据.

  16. Observation on Treatment of Senile pruritus with Shen Qing Antipruritic Lotion steam treatment Combined with the Western medicine%中药汽疗联合西药治疗老年性皮肤瘙痒症55例疗效观察

    Institute of Scientific and Technical Information of China (English)

    雷雯霓; 刘兰; 吴波

    2012-01-01

    目的 观察中药汽疗联合西药治疗老年性皮肤瘙痒症的疗效.方法 将103例患者随机分成两组,对照组48例采用口服盐酸左西替利嗪片及外用本院制剂5%尿素霜+卤米松乳膏;治疗组55例在对照组治疗基础上予以中药汽疗(药物组成:当归10克,白藓皮30克,蛇床子30克,姜黄10克,没药5克,地肤子30克,土茯苓20克,银花15克,千里光15克,苦参15克).结果 治疗组和对照组痊愈率分别为49.09%和12.50%;总显效率分别为74.55%和43.75%;两组比较差异有显著性意义(P<0.01),治疗组疗效优于对照组.结论 中药汽疗联合西药治疗老年性皮肤瘙痒症疗效显著.

  17. Drug: D00739 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available ) C17H27NO3. HCl 329.1758 329.8621 D00739.gif Anesthetic [topical] ATC code: C05AD07 D04AB07 Anatomical Ther...HISTAMINES, ANESTHETICS, ETC. D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. D04AB Anesthetics for topic

  18. Drug: D03959 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available Antipruritic [immunomodulator monoclonal antibody which decreases the activation, migration, and adhesion o...f T-cells] ATC code: L04AA21 anti-CD11a monoclonal antibody CD11a [HSA:3683] [KO:K05718] hsa04514(3683) Cell

  19. Ondansetron Treatment in a Child Presenting with Chronic Intractable Pruritus

    OpenAIRE

    Chantal Frigon; Joëlle Desparmet

    2006-01-01

    The case of a seven-year-old boy with chronic pruritus secondary to a giant congenital melanocytic nevus is presented. The pruritus did not respond to conventional antipruritic drug treatment, but responded to ondansetron, a selective antagonist of 5-hydroxytryptamine type 3 receptors.

  20. Ondansetron Treatment in a Child Presenting with Chronic Intractable Pruritus

    Directory of Open Access Journals (Sweden)

    Chantal Frigon

    2006-01-01

    Full Text Available The case of a seven-year-old boy with chronic pruritus secondary to a giant congenital melanocytic nevus is presented. The pruritus did not respond to conventional antipruritic drug treatment, but responded to ondansetron, a selective antagonist of 5-hydroxytryptamine type 3 receptors.

  1. Neurologic Itch Management.

    Science.gov (United States)

    Şavk, Ekin

    2016-01-01

    Neurologic itch is defined as pruritus resulting from any dysfunction of the nervous system. Itch arising due to a neuroanatomic pathology is seen to be neuropathic. Causes of neuropathic itch range from localized entrapment of a peripheral nerve to generalized degeneration of small nerve fibers. Antipruritic medications commonly used for other types of itch such as antihistamines and corticosteroids lack efficacy in neuropathic itch. Currently there are no therapeutic options that offer relief in all types of neuropathic pruritus, and treatment strategies vary according to etiology. It is best to decide on the appropriate tests and procedures in collaboration with a neurologist during the initial work-up. Treatment of neuropathic itch includes general antipruritic measures, local or systemic pharmacotherapy, various physical modalities, and surgery. Surgical intervention is the obvious choice of therapy in cases of spinal or cerebral mass, abscess, or hemorrhagic stroke, and may provide decompression in entrapment neuropathies. Symptomatic treatment is needed in the vast majority of patients. General antipruritic measures should be encouraged. Local treatment agents with at least some antipruritic effect include capsaicin, local anesthetics, doxepin, tacrolimus, and botulinum toxin A. Current systemic therapy relies on anticonvulsants such as gabapentin and pregabalin. Phototherapy, transcutaneous electrical nerve stimulation, and physical therapy have also been of value in selected cases. Among the avenues to be explored are transcranial magnetic stimulation of the brain, new topical cannabinoid receptor agonists, various modes of acupuncture, a holistic approach with healing touch, and cell transplantation to the spinal cord. PMID:27578080

  2. TriCalm® hydrogel is significantly superior to 2% diphenhydramine and 1% hydrocortisone in reducing the peak intensity, duration, and overall magnitude of cowhage-induced itch

    Directory of Open Access Journals (Sweden)

    Papoiu ADP

    2015-04-01

    Full Text Available Alexandru DP Papoiu,1 Hunza Chaudhry,2 Erin C Hayes,2 Yiong-Huak Chan,3 Kenneth D Herbst4 1Independent contractor, San Diego, CA, USA: 2Cosmederm Bioscience, Inc., San Diego, CA, USA; 3Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 4Department of Medicine, University of California, San Diego, San Diego, CA, USA Background: Itch is one of the most frequent skin complaints and its treatment is challenging. From a neurophysiological perspective, two distinct peripheral and spinothalamic pathways have been described for itch transmission: a histaminergic pathway and a nonhistaminergic pathway mediated by protease-activated receptors (PAR2 and 4. The nonhistaminergic itch pathway can be activated exogenously by spicules of cowhage, a tropical plant that releases a cysteine protease named mucunain that binds to and activates PAR2 and PAR4. Purpose: This study was conducted to assess the antipruritic effect of a novel over-the-counter (OTC steroid-free topical hydrogel formulation, TriCalm®, in reducing itch intensity and duration, when itch was induced with cowhage, and compared it with two other commonly used OTC anti-itch drugs. Study participants and methods: This double-blinded, vehicle-controlled, randomized, crossover study recorded itch intensity and duration in 48 healthy subjects before and after skin treatment with TriCalm hydrogel, 2% diphenhydramine, 1% hydrocortisone, and hydrogel vehicle, used as a vehicle control. Results: TriCalm hydrogel significantly reduced the peak intensity and duration of cowhage-induced itch when compared to the control itch curve, and was significantly superior to the two other OTC antipruritic agents and its own vehicle in antipruritic effect. TriCalm hydrogel was eight times more effective than 1% hydrocortisone and almost six times more effective than 2% diphenhydramine in antipruritic action, as evaluated by the reduction of area under the curve

  3. [Contact allergy to essential oils].

    Science.gov (United States)

    Selvåg, E; Holm, J O; Thune, P

    1995-11-10

    Ethereal oils are widely used, in food, toothpaste, as flavouring agents in perfumes and cosmetics, and in dermatological treatment, as antiseptics, adstringenta, antipruritic tinctures, lotions and pomades. The use of ethereal oils seems to have increased in recent years, probably due to a growing interest in alternative medicine, and especially aromatherapy. By describing the cases of three patients with allergic contact dermatitis, we wish to point out possible unwanted side effects of using ethereal oils. PMID:7491578

  4. A Randomised Trial Evaluating the Effects of the TRPV1 Antagonist SB705498 on Pruritus Induced by Histamine, and Cowhage Challenge in Healthy Volunteers

    OpenAIRE

    Gibson, Rachel A.; Jon Robertson; Harshna Mistry; Stewart McCallum; Disala Fernando; Melody Wyres; Gil Yosipovitch

    2014-01-01

    BACKGROUND: Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel widely expressed in skin tissues, and peripheral sensory nerve fibres. Activation of TRPV1 releases neuropeptides; the resulting neurogenic inflammation is believed to contribute to the development of pruritus. A TRPV1 antagonist has the potential to perform as an anti-pruritic agent. SB705498 is a TRPV1 antagonist that has demonstrated in vitro activity against cloned TRPV1 human receptors and...

  5. Investigation of in vitro Opioid Receptor Binding Activities of Some Turkish Salvia species

    OpenAIRE

    Özge Gündüz Çınar; Hasan Kırmızıbekmez; Galip Akaydın; Erdem Yesilada

    2011-01-01

    Kappa Opioid Peptide Receptor (KOPr) activation produces analgesic, psychotomimetic, diuretic and antipruritic effects. KOPr ligands are investigated for their potential roles in the treatment of addiction, depression, feeding behavior, psychosis and schizophrenia. In this study the methanolic extracts of a number of Salvia species which are native to Turkey (S. tomentosa, S. tchihatcheffii , S. rosifolia, S. dichroantha and S. sclarea) were tested for their potential binding to opioid recept...

  6. A Randomised Trial Evaluating the Effects of the TRPV1 Antagonist SB705498 on Pruritus Induced by Histamine, and Cowhage Challenge in Healthy Volunteers

    OpenAIRE

    Gibson, Rachel A.; Robertson, Jon; Mistry, Harshna; McCallum, Stewart; Fernando, Disala; Wyres, Melody; Yosipovitch, Gil

    2014-01-01

    Background Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel widely expressed in skin tissues, and peripheral sensory nerve fibres. Activation of TRPV1 releases neuropeptides; the resulting neurogenic inflammation is believed to contribute to the development of pruritus. A TRPV1 antagonist has the potential to perform as an anti-pruritic agent. SB705498 is a TRPV1 antagonist that has demonstrated in vitro activity against cloned TRPV1 human receptors and ...

  7. Polidocanol inhibits cowhage - but not histamine-induced itch in humans.

    Science.gov (United States)

    Hawro, Tomasz; Fluhr, Joachim W; Mengeaud, Valérie; Redoulès, Daniel; Church, Martin K; Maurer, Marcus; Metz, Martin

    2014-12-01

    Polidocanol is a local anaesthetic and antipruritic compound that is used in the treatment of itching skin conditions such as eczema. Its mechanisms of action are largely ill defined. This study has compared the antipruritic efficacy of topical polidocanol in histamine-induced itch and a histamine-independent, cowhage-induced model of pruritus. Polidocanol (3%) or vehicle was applied topically under occlusion for 1 h to the forearms of 45 healthy volunteers before itch was provoked by rubbing in 40-45 spicules of cowhage or skin prick testing with 10 mg/ml histamine. Itch was recorded at 1-min intervals for 30 min on a 100-mm visual analogue scale. Polidocanol significantly reduced the area under the curve for cowhage-induced itch by 58% (P < 0.05), but had no significant effect on histamine-induced itch. This result underlines the importance of histamine-independent itch models in the development of topical antipruritic agents.

  8. Thalidomide for the treatment of chronic refractory pruritus.

    Science.gov (United States)

    Sharma, Divya; Kwatra, Shawn G

    2016-02-01

    Pruritus is a common and often times difficult to treat symptom in many dermatologic and systemic diseases. For pruritus with an inflammatory or autoimmune origin, therapies such as topical corticosteroids and antihistamines are often initiated. However, in the case that these and additional systemic therapies are ineffective, thalidomide, an immunomodulator and neuromodulator, may be a useful alternative treatment. Considerable relief of chronic pruritus has been demonstrated with thalidomide in case reports, case series, and controlled trials. Double-blind controlled studies demonstrated thalidomide's efficacy as an antipruritic agent in patients with uremic pruritus, primary biliary cirrhosis, and prurigo nodularis. In case reports, case series, and open-label trials, thalidomide significantly reduced pruritus associated with conditions such as actinic prurigo and paraneoplastic pruritus. Because of variations in study design and evaluation of antipruritic effect, it is difficult to fully understand thalidomide's role based on the evidence described to date in the medical literature. In this review, we provide an overview of the reported findings and evaluate thalidomide's utility in managing refractory pruritus in the context of its adverse risk profile. We propose that thalidomide can be an alternative or combination antipruritic treatment for patients who do not obtain enough relief from conservative therapy.

  9. 肤舒止痒膏联合西替利嗪口服液治疗儿童湿疹的临床疗效观察

    Institute of Scientific and Technical Information of China (English)

    张彤; 张江安

    2013-01-01

    Objective:To observe the efficacy and safety of Shu Antipruritic Skin Cream combined with Cetirizine oral liquid in treatment of children with eczema. Methods:60 cases were randomly divided into the treatment group and 62 cases in the control group,.The treatment group was treated with Shu Antipruritic Skin Cream with Cetirizine oral liquid ,and the control group with Cetirizine oral liquid and Hydrocortisone Butyrate. The response was evaluated at 1 month .Results:The effective rate of the treatment group was 83.05%, 66.67% in the control group. There was a significant difference between the two groups’ effective rate (P=0.034) .Conclusion:The effective rate of Shu Antipruritic Skin Cream combined with Cetirizine oral liquid is high in treatment of children with eczema , and has no side effect of steroids.%目的:观察肤舒止痒膏联合西替利嗪口服液治疗儿童湿疹的疗效和安全性。方法:随机分为治疗组60例和对照组62例,两组均口服西替利嗪口服液,治疗组外用肤舒止痒膏,对照组外用丁酸氢化可的松软膏,治疗1月后判效。结果:治疗组有效率为83.05%,对照组为66.67%,二者差异有统计学意义(P=0.034)。结论:肤舒止痒膏联合西替利嗪口服液治疗儿童湿疹临床痊愈率高,且无激素副作用。

  10. Reduction of severity of pruritus after elective caesarean section under spinal anaesthesia with subarachnoid morphine: a randomised comparison of prophylactic granisetron and ondansetron.

    LENUS (Irish Health Repository)

    Tan, T

    2012-02-01

    BACKGROUND: The incidence of pruritus after elective caesarean section under spinal anaesthesia with subarachnoid morphine may be 60-100%, and is a common cause of maternal dissatisfaction. Ondansetron has been shown to reduce pruritus but the effect is short-lived. The objective of this randomized double-blind trial was to evaluate the anti-pruritic efficacy of granisetron compared with ondansetron. METHODS: Eighty ASA I or II women undergoing elective caesarean section received spinal anaesthesia with 0.5% hyperbaric bupivacaine 10 mg, fentanyl 25 microg and preservative-free morphine 150 microg. After delivery of the baby and clamping of the umbilical cord, they were randomised to receive granisetron 3mg i.v. (group G) or ondansetron 8 mg i.v. (group O). RESULTS: The two groups were similar for age, gestational age, height and weight. According to visual analogue pruritus scores, patients in group G experienced less pruritus at 8h (P=0.003) and 24h (P=0.01). Fewer patients in group G (n=8) than group O (n=18) required rescue anti-pruritic medication (P=0.03). Satisfaction scores were also higher in group G than in group O (P=0.03). There was no difference in overall incidence of pruritus, nausea and vomiting, and visual analogue pain scores between the two groups. CONCLUSIONS: Administration of granisetron 3mg i.v. reduces the severity of pruritus and the use of rescue anti-pruritic medication, and improves satisfaction but does not reduce the overall incidence of pruritus in women who have received subarachnoid morphine 150 microg compared to ondansetron 8 mg i.v.

  11. Drug: D00733 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available D00733 Drug Dibucaine (USP); Cinchocaine (INN); Nupercaine (TN) C20H29N3O2 343.226 ...l anesthetics C05AD04 Cinchocaine D00733 Dibucaine (USP); Cinchocaine (INN) D DERMATOLOGICALS D04 ANTIPRURIT...AB Anesthetics for topical use D04AB02 Cinchocaine D00733 Dibucaine (USP); Cinchocaine (INN) N NERVOUS SYSTE...M N01 ANESTHETICS N01B ANESTHETICS, LOCAL N01BB Amides N01BB06 Cinchocaine D00733...l anesthetics S01HA06 Cinchocaine D00733 Dibucaine (USP); Cinchocaine (INN) S02 OTOLOGICALS S02D OTHER OTOLO

  12. Drug: D02220 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE C05AD Local anesthetics C05AD04 Cinchocaine D02220 Dibucain... ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. D04AB Anesthetics for topical use D04AB02 Cinchoca... ANESTHETICS, LOCAL N01BB Amides N01BB06 Cinchocaine D02220 Dibucaine hydrochloride (JP16/USP) S SENSORY ORG...ANS S01 OPHTHALMOLOGICALS S01H LOCAL ANESTHETICS S01HA Local anesthetics S01HA06 Cinchocaine D02220 Dibucain...s and anesthetics S02DA04 Cinchocaine D02220 Dibucaine hydrochloride (JP16/USP) Target-based classification

  13. Seizures due to high dose camphor ingestion.

    Science.gov (United States)

    Tekin, Hande Gazeteci; Gökben, Sarenur; Serdaroğlu, Gül

    2015-12-01

    Camphor is a cyclic ketone of the hydro aromatic terpene group. Today it is frequently used as a prescription or non-prescription topical antitussive, analgesic, anesthetic and antipruritic agent. Camphor which is considered an innocent drug by parents and physicians is a common household item which can lead to severe poisoning in children even when taken in small amounts. Neurotoxicity in the form of seizures can ocur soon after ingestion. A two-year old female patient who presented with a complaint of generalized tonic-clonic seizures after oral ingestion of camphor is presented. PMID:26884696

  14. The excimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model.

    Science.gov (United States)

    Kamo, Atsuko; Tominaga, Mitsutoshi; Kamata, Yayoi; Kaneda, Kazuyuki; Ko, Kyi C; Matsuda, Hironori; Kimura, Utako; Ogawa, Hideoki; Takamori, Kenji

    2014-12-01

    Epidermal hyperinnervation, which is thought to underlie intractable pruritus, has been observed in patients with atopic dermatitis (AD). The epidermal expression of axonal guidance molecules has been reported to regulate epidermal hyperinnervation. Previously, we showed that the excimer lamp has antihyperinnervative effects in nonpruritic dry-skin model mice, although epidermal expression of axonal guidance molecules was unchanged. Therefore, we investigated the antipruritic effects of excimer lamp irradiation and its mechanism of action. A single irradiation of AD model mice significantly inhibited itch-related behavior 1 day later, following improvement in the dermatitis score. In addition, irradiation of nerve fibers formed by cultured dorsal root ganglion neurons increased bleb formation and decreased nerve fiber expression of nicotinamide mononucleotide adenylyl transferase 2, suggesting degenerative changes in these fibers. We also analyzed whether attaching a cutoff excimer filter (COF) to the lamp, thus decreasing cytotoxic wavelengths, altered hyperinnervation and the production of cyclobutane pyrimidine dimer (CPD), a DNA damage marker, in dry-skin model mice. Irradiation with COF decreased CPD production in keratinocytes, as well as having an antihyperinnervative effect, indicating that the antipruritic effects of excimer lamp irradiation with COF are due to induction of epidermal nerve degeneration and reduced DNA damage.

  15. [Pruritus in systemic diseases : Common and rare etiologies].

    Science.gov (United States)

    Kremer, A E; Mettang, T

    2016-08-01

    Chronic pruritus is a symptom of various internal disorders. In contrast to dermatological diseases, pruritus does not present with primary skin alterations in these patients. However, intense scratching may cause secondary skin changes such as abrasion, excoriation, prurigo nodularis, or in rare cases even scaring. The most common internal medicine causes for chronic pruritus are chronic kidney disease, hepatobiliary and hematological disorders as well as adverse drug reactions. Pruritus is less commonly seen in patients with endocrine or metabolic diseases, malabsorption syndromes, infectious diseases and solid tumors. The pathogenesis of pruritus in these disorders remains largely elusive, albeit preliminary insights have been gained for uremic and cholestatic pruritus. Antipruritic treatment is therefore symptomatic in most cases and may represent a clinical challenge. The calcium channel blockers gabapentin and pregabalin have the best proven efficacy in chronic kidney disease-associated pruritus. In Japan nalfurafine, a κ-opioid receptor agonist, has been licensed for this indication. UVB light may also attenuate uremic symptoms. In patients suffering from hepatobiliary disorders the sequestrant cholestyramine and the enzyme inducer rifampicin are effective. Furthermore, μ‑opioid receptor antagonists and sertraline may be used to ameliorate cholestatic pruritus. So far, no randomized controlled trials have been performed for chronic itch in other internal medicine disorders. Antipruritic treatment is mainly based on effective therapy of the underlying disease.

  16. The excimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model.

    Science.gov (United States)

    Kamo, Atsuko; Tominaga, Mitsutoshi; Kamata, Yayoi; Kaneda, Kazuyuki; Ko, Kyi C; Matsuda, Hironori; Kimura, Utako; Ogawa, Hideoki; Takamori, Kenji

    2014-12-01

    Epidermal hyperinnervation, which is thought to underlie intractable pruritus, has been observed in patients with atopic dermatitis (AD). The epidermal expression of axonal guidance molecules has been reported to regulate epidermal hyperinnervation. Previously, we showed that the excimer lamp has antihyperinnervative effects in nonpruritic dry-skin model mice, although epidermal expression of axonal guidance molecules was unchanged. Therefore, we investigated the antipruritic effects of excimer lamp irradiation and its mechanism of action. A single irradiation of AD model mice significantly inhibited itch-related behavior 1 day later, following improvement in the dermatitis score. In addition, irradiation of nerve fibers formed by cultured dorsal root ganglion neurons increased bleb formation and decreased nerve fiber expression of nicotinamide mononucleotide adenylyl transferase 2, suggesting degenerative changes in these fibers. We also analyzed whether attaching a cutoff excimer filter (COF) to the lamp, thus decreasing cytotoxic wavelengths, altered hyperinnervation and the production of cyclobutane pyrimidine dimer (CPD), a DNA damage marker, in dry-skin model mice. Irradiation with COF decreased CPD production in keratinocytes, as well as having an antihyperinnervative effect, indicating that the antipruritic effects of excimer lamp irradiation with COF are due to induction of epidermal nerve degeneration and reduced DNA damage. PMID:24940652

  17. Requirement for additional treatment for dogs with atopic dermatitis undergoing allergen-specific immunotherapy.

    Science.gov (United States)

    Colombo, S; Hill, P B; Shaw, D J; Thoday, K L

    2007-06-23

    Allergen-specific immunotherapy (ASIT) is one of the main treatments for atopic dermatitis in dogs, but it often requires additional treatments such as antibacterial and antifungal therapy for secondary bacterial and yeast infections, or antipruritic drugs to control the clinical signs or treat the adverse effects of the immunotherapy. Twenty-seven dogs enrolled in a study of ASIT were clinically assessed four times over a period of nine months; their requirement for treatment for secondary bacterial and yeast infections, for the administration of glucocorticoids as additional antipruritic therapy, and for the treatment of any adverse effects of the ASIT were evaluated. Twenty (74 per cent) of the dogs were treated for superficial bacterial pyoderma, 18 (66.6 per cent) required treatment for Malassezia species dermatitis on one or more occasions, eight (29.6 per cent) required treatment for otitis externa due to Malassezia species or bacteria, and eight required glucocorticoids to control their clinical signs. Five (18.5 per cent) of the dogs experienced adverse effects due to the ASIT and two required treatment with antihistamines (H1 receptor antagonists) in order to continue with the ASIT. PMID:17586789

  18. Gabapentin and pregabalin for the treatment of chronic pruritus.

    Science.gov (United States)

    Matsuda, Kazuki M; Sharma, Divya; Schonfeld, Ariel R; Kwatra, Shawn G

    2016-09-01

    Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative therapies such as neuroactive agents. Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for relieving chronic pruritus is explored. The findings from original sources published to date to evaluate the use of gabapentin and pregabalin as antipruritic agents are explored. They are found to be promising alternative treatments for the relief of several forms of chronic pruritus, particularly uremic pruritus and neuropathic or neurogenic itch, in patients who fail conservative therapies.

  19. Niacinamide - mechanisms of action and its topical use in dermatology.

    Science.gov (United States)

    Wohlrab, Johannes; Kreft, Daniela

    2014-01-01

    Niacinamide, an amide of vitamin B3 (niacin), is a hydrophilic endogenous substance. Its effects after epicutaneous application have long been described in the literature. Given a sufficient bioavailability, niacinamide has antipruritic, antimicrobial, vasoactive, photo-protective, sebostatic and lightening effects depending on its concentration. Within a complex metabolic system niacinamide controls the NFκB-mediated transcription of signalling molecules by inhibiting the nuclear poly (ADP-ribose) polymerase-1 (PARP-1). Niacinamide is a well-tolerated and safe substance often used in cosmetics. Clinical data for its therapeutic use in various dermatoses can increasingly be found in the literature. Although the existing data are not sufficient for a scientifically founded evaluation, it can be stated that the use of niacinamide in galenic preparations for epicutaneous application offers most interesting prospects.

  20. Oleanolic acid and related derivatives as medicinally important compounds.

    Science.gov (United States)

    Sultana, Nighat; Ata, Athar

    2008-12-01

    Oleanolic acid has been isolated from chloroform extract of Olea ferruginea Royle after removal of organic bases and free acids. The literature survey revealed it to be biologically very important. In this review the biological significance of oleanolic acid and its derivatives has been discussed. The aim of this review is to update current knowledge on oleanolic acid and its natural and semisynthetic analogs, focussing on its cytotoxic, antitumer, antioxidant, anti-inflamatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, hepatoprotective, anti-inflammatory, antipruritic, spasmolytic activity, anti-angiogenic, antiallergic, antiviral and immunomodulatory activities. We present in this review, for the first time, a compilation of the most relevant scientific papers and technical reports of the chemical, pre-clinical and clinical research on the properties of oleanolic acid and its derivatives.

  1. Gabapentin and pregabalin for the treatment of chronic pruritus.

    Science.gov (United States)

    Matsuda, Kazuki M; Sharma, Divya; Schonfeld, Ariel R; Kwatra, Shawn G

    2016-09-01

    Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative therapies such as neuroactive agents. Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for relieving chronic pruritus is explored. The findings from original sources published to date to evaluate the use of gabapentin and pregabalin as antipruritic agents are explored. They are found to be promising alternative treatments for the relief of several forms of chronic pruritus, particularly uremic pruritus and neuropathic or neurogenic itch, in patients who fail conservative therapies. PMID:27206757

  2. Oleanolic acid and related derivatives as medicinally important compounds.

    Science.gov (United States)

    Sultana, Nighat; Ata, Athar

    2008-12-01

    Oleanolic acid has been isolated from chloroform extract of Olea ferruginea Royle after removal of organic bases and free acids. The literature survey revealed it to be biologically very important. In this review the biological significance of oleanolic acid and its derivatives has been discussed. The aim of this review is to update current knowledge on oleanolic acid and its natural and semisynthetic analogs, focussing on its cytotoxic, antitumer, antioxidant, anti-inflamatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, hepatoprotective, anti-inflammatory, antipruritic, spasmolytic activity, anti-angiogenic, antiallergic, antiviral and immunomodulatory activities. We present in this review, for the first time, a compilation of the most relevant scientific papers and technical reports of the chemical, pre-clinical and clinical research on the properties of oleanolic acid and its derivatives. PMID:18618318

  3. Coal tar in dermatology

    Energy Technology Data Exchange (ETDEWEB)

    Roelofzen, J.H.J.; Aben, K.K.H.; Van Der Valk, P.G.M.; Van Houtum, J.L.M.; Van De Kerkhof, P.C.M.; Kiemeney, L.A.L.M. [Radboud University Nijmegen Medical Center, Nijmegen (Netherlands). Dept. of Dermatology

    2007-07-01

    Coal tar is one of the oldest treatments for psoriasis and eczema. It has anti-inflammatory, antibacterial, antipruritic and antimitotic effects. The short-term side effects are folliculitis, irritation and contact allergy. Coal tar contains carcinogens. The carcinogenicity of coal tar has been shown in animal studies and studies in occupational settings. There is no clear evidence of an increased risk of skin tumors or internal tumors. Until now, most studies have been fairly small and they did not investigate the risk of coal tar alone, but the risk of coal tar combined with other therapies. New, well-designed, epidemiological studies are necessary to assess the risk of skin tumors and other malignancies after dermatological use of coal tar.

  4. Preclinical and human surrogate models of itch

    DEFF Research Database (Denmark)

    Hoeck, Emil August; Marker, Jens Broch; Gazerani, Parisa;

    2016-01-01

    Pruritus, or simply itch, is a debilitating symptom that significantly decreases the quality of life in a wide range of clinical conditions. While histamine remains the most studied mediator of itch in humans, treatment options for chronic itch, in particular antihistamine-resistant itch, are lim...... currently applied in animals and humans. This article is protected by copyright. All rights reserved.......Pruritus, or simply itch, is a debilitating symptom that significantly decreases the quality of life in a wide range of clinical conditions. While histamine remains the most studied mediator of itch in humans, treatment options for chronic itch, in particular antihistamine-resistant itch......, are limited. Relevant preclinical and human surrogate models of non-histaminergic itch are needed to accelerate the development of novel antipruritics and diagnostic tools. Advances in basic itch research have facilitated the development of diverse models of itch and associated dysesthesiae. While...

  5. 止痒洗剂联合妇炎消生物敷料栓治疗妊娠合并外阴阴道假丝酵母菌病的临床观察%Clinical observation on the effect of anti -itching lotion combined with Fuyanxiao biological dressing supposi-tory in treatment of pregnancy and vulvovaginal candidiasis

    Institute of Scientific and Technical Information of China (English)

    康玉惠

    2015-01-01

    目的:观察止痒洗剂联合妇炎消生物敷料栓治疗妊娠合并外阴阴道假丝酵母菌病(VVC)的临床疗效及复发率。方法选择妊娠合并 VVC 患者236例,将患者以随机数字表法分为两组:治疗组、对照组,各118例。治疗组采用止痒洗剂联合妇炎消生物敷料栓治疗,对照组单独采用妇炎消生物敷料栓治疗,疗程结束后比较两组的临床疗效及复发率。结果治疗组治愈率90.68%,高于对照组的57.62(χ2=10.731,P <0.01);治疗组复发率3.39%,低于对照组的13.56%,差异有统计学意义(χ2=10.733,P <0.05)。结论止痒洗剂联合妇炎消生物敷料栓治疗妊娠合并 VVC 可有效改善患者的临床症状,降低复发率。%Objective To observe the effect of antipruritic lotion combined Fuyanxiao with biological dress-ing suppository in the treatment of vulvovaginal candidiasis in pregnancy(VVC)the clinical curative effect and the recurrence rate.Methods 236 patients with pregnancy complicated with VVC,would be in community were randomly divided into the two groups:combination treatment group,single drug group,118 cases in each.Combination therapy using antipruritic lotion combined Fuyanxiao biological dressing suppository combined treatment,the control group was treated by Fuyanxiao biological dressing suppository treatment,two groups of clinical efficacy and recurrence rate after the end of treatment were compared.Results The cure rate in the combined treatment group was 90.68%,which was higher than 57.62 % in the control group(χ2 =10.731,P <0.01);The recurrence rate in the combined treatment group was 3.39%,which was lower than 13.56% in the control group(χ2 =10.733,P <0.05).Conclusion The antipruritic lotion combined Fuyanxiao biological dressing suppository in the treatment of pregnancy with VVC can effectively improve the clinical symptoms of patients,reduce the recurrence rate.

  6. 内源性大麻素系统调节瘙痒的研究进展%Progress of the regulation of endocannabinoid system on pruritus

    Institute of Scientific and Technical Information of China (English)

    刘秀兰; 上官王宁

    2012-01-01

    Background Pruritus can be caused by numerous drugs and diseases,but the pathogenesis of pruritus is still not clearly elucidated.It has been shown that the endocannabinoid system plays an important role in regulating pruritus and influences the occurrence and development of pruritus.Objective To review home and abroad literatures relating to the regulation of endocannabinoid system on pruritus in recent years. Content Cannabinoid receptor 1 agonist reduces pruritus while its antagonist induces pruritus.Cannabinoid receptor 2 antagonist,endocannabinoids simiar compounds and fatty acid amide hydrolase indirectly inhibit pruritus.Furthermore the antipruritic effect of endocannabinoids may be partly mediated by transient receptor potential vanilloid type. Trend The endocannabinoid system could serve as antipruritic targets for different etiology of itch,but the mechanisms via which the endocannabinoid system regulate pruritus remains unclear,requiring further study and discussion.%背景 很多药物和疾病都能引起瘙痒,但目前有关瘙痒的病理生理学还不完全清楚.研究发现,内源性大麻素系统在调节瘙痒中起着重要的作用,影响着瘙痒的发生与发展.目的 就近年来国内外有关内源性大麻素系统调节瘙痒的文献作一综述. 内容 大麻素受体1 (cannabinoid receptor 1,CB1)激动剂缓解瘙痒,拮抗剂诱发瘙痒.大麻素受体2(cannabinoid receptor 2,CB2)拮抗剂、内源性大麻素类化合物和脂肪酰胺水解酶(fatty acid amide hydrolase,FAAH)间接抑制瘙痒.此外,内源性大麻素的止痒作用可能部分是通过瞬时受体电位香草类受体(transient receptor potential vanilloid type,TRPV)介导的.趋向 内源性大麻素系统可能成为将来各种病因学全身性瘙痒的止痒靶点,但其调节瘙痒的机制还不十分清楚,需要进一步的研究和探讨.

  7. Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases.

    Science.gov (United States)

    Basith, Shaherin; Cui, Minghua; Hong, Sunhye; Choi, Sun

    2016-01-01

    Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been well characterized. The potential applications of capsaicin range from food flavorings to therapeutics. Indeed, capsaicin and few of its analogues have featured in clinical research covered by more than a thousand patents. Previous records suggest pleiotropic pharmacological activities of capsaicin such as an analgesic, anti-obesity, anti-pruritic, anti-inflammatory, anti-apoptotic, anti-cancer, anti-oxidant, and neuro-protective functions. Moreover, emerging data indicate its clinical significance in treating vascular-related diseases, metabolic syndrome, and gastro-protective effects. The dearth of potent drugs for management of such disorders necessitates the urge for further research into the pharmacological aspects of capsaicin. This review summarizes the historical background, source, structure and analogues of capsaicin, and capsaicin-triggered TRPV1 signaling and desensitization processes. In particular, we will focus on the therapeutic roles of capsaicin and its analogues in both normal and pathophysiological conditions. PMID:27455231

  8. Triamcinolone Acetonide Local Blocking Followed by lavender for Treating Keloid%曲安奈德联合薰衣草精油治疗瘢痕疙瘩的疗效观察

    Institute of Scientific and Technical Information of China (English)

    李薇薇; 闵峰

    2011-01-01

    Objective: To investigate the efficacy of lavender in treating recurrent Keloids pretreated with triamcinolone acetonide local blocking.Methods:184 cases of recurrent Keloid were treated in this way for 2 years.Results: The curative rate was 90.2 % and total effective rate 95.1%.Conclusion:lavender has good effect for curing Keloid and preventing recurrence.It also has anti-pruritic and pain relieving effects.%目的:观察薰衣草精油防治瘢痕疙瘩局封后复发的疗效.方法:对184例瘢痕疙瘩患者用曲安奈德局部封闭后外涂薰衣草精油.结果:两年后治愈率达90.2%、有效率达95.1%.结论:薰衣草精油对防治瘢痕疙瘩增生与复发有较好的疗效.

  9. Treatment outcome of Paederus dermatitis due to rove beetles (Coleoptera: Staphylinidae) on guinea pigs.

    Science.gov (United States)

    Fakoorziba, M R; Eghbal, F; Azizi, K; Moemenbellah-Fard, M D

    2011-08-01

    Linear dermatitis (or dermatitis linearis, DL) is a skin blistering inflammatory lesion caused by exposure to the pederin toxin from rove beetles. Although it is prevalent in many countries of the Middle East region, this is not a notifiable disease. In recent years, a number of clinical symptoms outbreaks of DL has been reported from a few neighboring countries of Iran, but no report of experimental treatment among small laboratory rodents is known. This is a prerequisite to ascertain the nature of the best treatment strategy in cases of infestation with these beetles, as it occurs among local settlers during hot seasons in certain parts of the southern Iranian province of Fars. Live Paederus beetles were collected, identified to species level, sexed apart and partly processed to obtain their hemolymph toxin pederin in ethanol for dermal application on guinea pigs. Two Paederus species were found. Paederus ilsae (Bernhauer) (Coleoptera: Staphylinidae) was more abundant than P. iliensis (Coiffait). Recovery from DL due to live P. ilsae beetles was quicker and less complex than that of pederin in ethanol on guinea pigs. The application of potassium permanganate with calamine to heal DL was also more effective than fluocinolone treatment. This topical corticosteroid is thus considered less able to avert the cytotoxic action of pederin on the skin of guinea pigs than the antipruritic and cleansing agents. It seems likely that fluocinolone has certain effects which delays the recovery period for the treated skin.

  10. LIKEN PLANUS

    Directory of Open Access Journals (Sweden)

    Herman Cipto

    2015-08-01

    Full Text Available Lichen planus (LP is an inflammation skin and mucous membrane disease that has characteristic clinical and pathologic features. Typical lesion of LP are small, flat-topped, polygonal, violaceous papules on the skin or reticular, white patch or plaque on mucous membrane. Nail involvement is manifested by longitudinal ridging, thinning and distal splitting and hair involvement is atrophic cicatrical alopesia. There was an increased risk of developing squamous cell carcinoma in the leasion of mucous membrane of oral cavity. Pathology of LP is the prototype of lichenoid interface dermatitis, which shows damage to the basal cell layer and a band-like dental lymphocytic infiltrate in close approximation to the epidermis. Other pathologic findings are compact orthokeratosis, wedge-shape hypergranulosis and irregular acanthosis. The treatment of LP in the main is largely symptomatic like antipruritic for itching. Therapies to suppress immune responses are commonly effective in treating LP, such as corticosteroid and cyclosporine topical or systemic. Other treatment are psoralene ultra violet A (PUVA or steroids.

  11. Harnessing the Therapeutic Potential of Capsaicin and Its Analogues in Pain and Other Diseases

    Directory of Open Access Journals (Sweden)

    Shaherin Basith

    2016-07-01

    Full Text Available Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been well characterized. The potential applications of capsaicin range from food flavorings to therapeutics. Indeed, capsaicin and few of its analogues have featured in clinical research covered by more than a thousand patents. Previous records suggest pleiotropic pharmacological activities of capsaicin such as an analgesic, anti-obesity, anti-pruritic, anti-inflammatory, anti-apoptotic, anti-cancer, anti-oxidant, and neuro-protective functions. Moreover, emerging data indicate its clinical significance in treating vascular-related diseases, metabolic syndrome, and gastro-protective effects. The dearth of potent drugs for management of such disorders necessitates the urge for further research into the pharmacological aspects of capsaicin. This review summarizes the historical background, source, structure and analogues of capsaicin, and capsaicin-triggered TRPV1 signaling and desensitization processes. In particular, we will focus on the therapeutic roles of capsaicin and its analogues in both normal and pathophysiological conditions.

  12. Cnidium monnieri: A Review of Traditional Uses, Phytochemical and Ethnopharmacological Properties.

    Science.gov (United States)

    Li, Yi-Min; Jia, Min; Li, Hua-Qiang; Zhang, Nai-Dan; Wen, Xian; Rahman, Khalid; Zhang, Qiao-Yan; Qin, Lu-Ping

    2015-01-01

    Cnidium monnieri (L.) Cuss., an annual plant of the Umbelliferae species is one of the most widely used traditional herbal medicines and its fruits have been used to treat a variety of diseases in China, Vietnam, and Japan. The aim of this review is to provide an up-to-date and comprehensive analysis of the botany, traditional uses, phytochemistry, pharmacology, toxicity and contraindication of Cnidium monnieri (L.) Cuss. and to provide future directions of research on this plant. To date, 350 compounds have been isolated and identified from Cnidium monnieri (L.) Cuss., including the main active constituent, coumarins. In vitro and in vivo studies suggest that osthole and other coumarin compounds possess wide range of pharmacological properties for the treatment of female genitals, male impotence, frigidity, skin-related diseases, and exhibit strong antipruritic, anti-allergic, antidermatophytic, antibacterial, antifungal, anti-osteoporotic effects. Although coumarins have been identified as the main active constituents responsible for the observed pharmacological effects, the molecular mechanisms of their actions are still unknown. Therefore, further studies are still required to reveal the structure-activity relationship of these active constituents. In addition, toxicological and clinical studies are also required to provide further data for pharmaceutical use. PMID:26243582

  13. Clinical Applications of Saffron (Crocus sativus) and its Constituents: A Review.

    Science.gov (United States)

    Moshiri, M; Vahabzadeh, M; Hosseinzadeh, H

    2015-06-01

    Commonly known as saffron, Crocus sativus L and its active components have shown several useful pharmacological effects such as anticonvulsant, antidepressant, anti-inflammatory, antitumor, radical scavenger effects, learning and memory improving effects, etc. There has been an increasing body of data on saffron use in medical databases within the last 20 years. In the current review, the strengths and weaknesses of some of the clinical trials about different pharmacological effects of saffron will be discussed C. sativus extract has been studied in 8 anti-depressant clinical trials in comparison to placebo or some antidepressant drugs, in which saffron showed effectiveness as an antidepressant drug. Clinical trials on anti-Alzheimer effect of saffron demonstrated that it was more effective than the placebo, and as effective as donepezil. 2 clinical trials on antipruritic and complexion promoter in skin care effects of saffron both confirmed that saffron was more efficient than the placebo. In another clinical trial, it was proved that in addition to the weight loss treatment, saffron could reduce snacking frequency. Clinical trials conducted on women with premenstrual syndrome showed that saffron could reduce suffering symptoms more than the placebo and similar to standard treatments.Furthermore, additional clinical trials on effects of saffron on erection dysfunction, allergies, cardiovascular and immune system as well as its safety, toxicity and human pharmacokinetics are reviewed herein.

  14. The efficacy of a commercial shampoo and whirlpooling in the treatment of canine pruritus - a double-blinded, randomized, placebo-controlled study.

    Science.gov (United States)

    Löflath, A; von Voigts-Rhetz, A; Jaeger, K; Schmid, M; Kuechenhoff, H; Mueller, R S

    2007-12-01

    Twenty-two dogs with a history of at least 4 weeks pruritus were studied to determine the effect of whirlpool use on the efficacy of topical therapy with an antipruritic shampoo (Allermyl, Virbac; Bad Oldesloe, Germany). Dogs in group 1 received initially topical therapy with conventional shampooing (2 mL shampoo per kilogram bodyweight) once weekly for 4 weeks. Dogs in group 2 received the same therapy using a whirlpool (Sanwhirl, Peter Aschauer GmbH; Gräfelfing, Germany). The treatments were crossed between the groups resulting in each dog in groups 1 and 2 receiving both therapies. Group 3 was the control group and was treated once weekly in the whirlpool without any shampoo during the 8 weeks of study. Prior to each therapy, dogs were evaluated by a clinician not aware of the type of treatment using a clinical scoring system (Canine Atopic Dermatitis Extent and Severity Index - CADESI). Owners evaluated the pruritus daily on a visual analogue scale. There was a significant difference in pruritus scores but not CADESI scores after therapy between the control treatment and the conventional shampoo therapy or shampoo treatment in the whirlpool. These results provide evidence for the short-term benefit of shampoo therapy for canine pruritus.

  15. The efficacy of a commercial shampoo and whirlpooling in the treatment of canine pruritus - a double-blinded, randomized, placebo-controlled study.

    Science.gov (United States)

    Löflath, A; von Voigts-Rhetz, A; Jaeger, K; Schmid, M; Kuechenhoff, H; Mueller, R S

    2007-12-01

    Twenty-two dogs with a history of at least 4 weeks pruritus were studied to determine the effect of whirlpool use on the efficacy of topical therapy with an antipruritic shampoo (Allermyl, Virbac; Bad Oldesloe, Germany). Dogs in group 1 received initially topical therapy with conventional shampooing (2 mL shampoo per kilogram bodyweight) once weekly for 4 weeks. Dogs in group 2 received the same therapy using a whirlpool (Sanwhirl, Peter Aschauer GmbH; Gräfelfing, Germany). The treatments were crossed between the groups resulting in each dog in groups 1 and 2 receiving both therapies. Group 3 was the control group and was treated once weekly in the whirlpool without any shampoo during the 8 weeks of study. Prior to each therapy, dogs were evaluated by a clinician not aware of the type of treatment using a clinical scoring system (Canine Atopic Dermatitis Extent and Severity Index - CADESI). Owners evaluated the pruritus daily on a visual analogue scale. There was a significant difference in pruritus scores but not CADESI scores after therapy between the control treatment and the conventional shampoo therapy or shampoo treatment in the whirlpool. These results provide evidence for the short-term benefit of shampoo therapy for canine pruritus. PMID:17991160

  16. Development of low-alcohol floral water mixed with extract from mugwort%复合型艾叶低醇驱蚊露的研制

    Institute of Scientific and Technical Information of China (English)

    张岳花; 曾平; 谢维跃; 汤志球; 李帜红; 黄向辉

    2013-01-01

    Objective To develop a low-alcohol floral water with long repellent time and low irritation. Meth-ods Using dimethyl phthalate 1,2- Benzenedicarboxylic acid ( BAAPE) as a mosquito repellent with addition of extracts from mugwort, mint and lavender in order to give the products antipruritic effect. The mixed problem was resolved with introduction of the PEG - 40 hydrogenated castor oil as a solubilizer. Results A low-alcohol floral water mixed with mugwort and the ethanol content below 25% was prepared. Tests showed that the mosquito repellent time of the product was more than 4. 7 hours,and the physical and chemical properties were in line with our company' s enterprise standards. Conclusion The product is suitable for using in home and travel because of its long repellent time and high safety.%目的 开发一种驱蚊时效长、刺激性低的低醇驱蚊露产品.方法 使用驱蚊酯作为蚊虫驱避剂,同时添加艾叶、薄荷、薰衣草天然植物提取物以赋予产品止痒健肤的功效,在配方中引入PEG-40氢化蓖麻油作为增溶剂解决混溶问题.结果 研制出一款乙醇含量在25%以下的复合型艾叶低醇驱蚊露,有效驱蚊时间达4.7h以上,各项理化指标均符合已制定的企业标准.结论 产品具有驱蚊时间长、安全性高的优点,适合各类人群居家及旅行使用.

  17. Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives

    Science.gov (United States)

    Parikh, Nisha R.; Mandal, Animesh; Bhatia, Deepak; Siveen, Kodappully Sivaraman; Sethi, Gautam

    2014-01-01

    Breast cancer is one of the most frequently diagnosed cancers and major cause of death in women in the world. Emerging evidence underscores the value of dietary and non-dietary phytochemicals, including triterpenoids, in the prevention and treatment of breast cancer. Oleanolic acid, an oleanane-type pentacyclic triterpenoid, is present in a large number of dietary and medicinal plants. Oleanolic acid and its derivatives exhibit several promising pharmacological activities, including antioxidant, anti-inflammatory, hepatoprotective, cardioprotective, antipruritic, spasmolytic, antiallergic, antimicrobial and antiviral effects. Numerous studies indicate that oleanolic acid and other oleanane triterpenoids modulate multiple intracellular signaling pathways and exert chemopreventive and antitumor activities in various in vitro and in vivo model systems. A series of novel synthetic oleanane triterpenoids have been prepared by chemical modifications of oleanolic acid and some of these compounds are considered to be the most potent anti-inflammatory and anticarcinogenic triterpenoids. Accumulating studies provide extensive evidence that synthetic oleanane derivatives inhibit proliferation and induce apoptosis of various cancer cells in vitro and demonstrate cancer preventive or antitumor efficacy in animal models of blood, breast, colon, connective tissue, liver, lung, pancreas, prostate and skin cancer. This review critically examines the potential role of oleanolic acid, oleanane triterpenoids and related synthetic compounds in the chemoprevention and treatment of mammary neoplasia. Both in vitro and in vivo studies on these agents and related molecular mechanisms are presented. Several challenges and future directions of research to translate already available impressive preclinical knowledge to clinical practice of breast cancer prevention and therapy are also presented. PMID:25395898

  18. Pathogenesis and Management of Pruritus in PBC and PSC.

    Science.gov (United States)

    Kremer, Andreas E; Namer, Barbara; Bolier, Ruth; Fischer, Michael J; Oude Elferink, Ronald P; Beuers, Ulrich

    2015-01-01

    Pruritus is a preeminent symptom in patients with chronic cholestatic liver disorders such as primary biliary cirrhosis and primary sclerosing cholangitis. More than two-thirds of these patients experience itching during the course of their disease. This symptom is also frequently observed in patients with other causes of cholestasis such as cholangiocarcinoma, inherited forms of cholestasis and intrahepatic cholestasis of pregnancy, but may accompany almost any other liver disease. The pathogenesis of pruritus of cholestasis remains largely elusive. Increased concentrations of bile salts, histamine, serotonin, progesterone metabolites and endogenous opioids have been controversially discussed as potential pruritogens. However, for these molecules, neither a correlation with itch intensity nor a causative link could be established. The G protein-coupled receptor for bile salts, TGR5, has been shown to be expressed in dorsal root ganglia and give rise to itch in rodents, albeit upon stimuli with suprapathological concentrations of bile salts. The potent neuronal activator lysophosphatidic acid (LPA) and its forming enzyme, autotaxin (ATX), could be identified in the serum of patients with cholestatic pruritus. ATX activity correlated with itch severity and effectiveness of several anti-pruritic therapeutic interventions in cholestatic patients. Thus, the ATX-LPA-axis may represent a key element in the pathogenesis of this agonizing symptom. Treatment options for pruritus of cholestasis remain limited to a few evidence-based and several experimental medical and interventional therapies. The current guideline-based recommendations include the anion exchange resins colestyramine, the pregnane X receptor-agonist and enzyme inducer rifampicin, the μ-opioid antagonist naltrexone, and the selective serotonin reuptake inhibitors sertraline. Still, a considerable part of patients is unresponsive to these drugs and requires experimental approaches including phototherapy

  19. Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.

    Directory of Open Access Journals (Sweden)

    Alexandru D P Papoiu

    Full Text Available BACKGROUND: Histamine is the prototypical pruritogen used in experimental itch induction. However, in most chronic pruritic diseases, itch is not predominantly mediated by histamine. Cowhage-induced itch, on the other hand, seems more characteristic of itch occurring in chronic pruritic diseases. OBJECTIVES: We tested the validity of cowhage as an itch-inducing agent by contrasting it with the classical itch inducer, histamine, in healthy subjects and atopic dermatitis (AD patients. We also investigated whether there was a cumulative effect when both agents were combined. METHODS: Fifteen healthy individuals and fifteen AD patients were recruited. Experimental itch induction was performed in eczema-free areas on the volar aspects of the forearm, using different itch inducers: histamine, cowhage and their combination thereof. Itch intensity was assessed continuously for 5.5 minutes after stimulus application using a computer-assisted visual analogue scale (COVAS. RESULTS: In both healthy and AD subjects, the mean and peak intensity of itch were higher after the application of cowhage compared to histamine, and were higher after the combined application of cowhage and histamine, compared to histamine alone (p<0.0001 in all cases. Itch intensity ratings were not significantly different between healthy and AD subjects for the same itch inducer used; however AD subjects exhibited a prolonged itch response in comparison to healthy subjects (p<0.001. CONCLUSIONS: Cowhage induced a more intense itch sensation compared to histamine. Cowhage was the dominant factor in itch perception when both pathways were stimulated in the same time. Cowhage-induced itch is a suitable model for the study of itch in AD and other chronic pruritic diseases, and it can serve as a new model for testing antipruritic drugs in humans.

  20. Bisabololoxide A, one of the main constituents in German chamomile extract, induces apoptosis in rat thymocytes.

    Science.gov (United States)

    Ogata, Ikuko; Kawanai, Takuya; Hashimoto, Erika; Nishimura, Yumiko; Oyama, Yasuo; Seo, Hakaru

    2010-01-01

    German chamomile (Matricaria recutita L.), one of the popular ingredients in herbal teas, has been traditionally used for medicinal purposes. Bisabololoxide A (BSBO) is one of the main constituents in this herb. BSBO is supposed to be principle in some bioactivities of German chamomile such as anti-inflammatory, gastrointestinal, and antipruritic actions. Although the use of German chamomile has spread, the information related to toxicity of BSBO is very limited. In present study, the cytotoxic effect of micromolar BSBO was cytometrically examined on rat thymocytes by using appropriate fluorescent dyes. When the cells were incubated with BSBO for 24 h, BSBO at concentrations of 30 microM or more significantly increased populations of dead cells, shrunken cells, and cells with phosphatidylserine exposed on membrane surface. Both cell shrinkage and externalization of membrane phosphatidylserine are general features in an early stage of apoptosis. In addition, BSBO significantly increased population of cells containing hypodiploid DNA, and the increase was completely attenuated by Z-VAD-FMK, a pan-inhibitor for caspases, indicating an involvement of caspase activation. Thus, it is likely that the type of cell death induced by BSBO is apoptosis. The significant changes in cellular parameters of rat thymocytes by BSBO were not observed when the concentration was 10 microM or less. Furthermore, the short incubation (3 h) of cells even with 30-100 microM BSBO did not significantly affect the cells. Therefore, it may be suggested that BSBO is practically safe when German chamomile is conventionally used. PMID:19834689

  1. Preparation of Green Tea Function Type Hair Shampoo%绿茶功能型洗发香波的研制

    Institute of Scientific and Technical Information of China (English)

    罗孟君; 熊海蓉; 蒋利华; 黄忠良; 陈宗高; 熊远福

    2012-01-01

    Using the water - soluble and efficacy of green tea effective composition, adding green tea hot water soaking extract to hair shampoo, through single factor experiment and orthogonal experiment, the op- timum material ratio and the technology process are abtained. By means of microbial detection and the feedback of voluntary reception test patients use, shows this hair shampoo not only can clean hair, also has the functions such as stop chip, antipruritic, soft hair, conditioning. The process is simple, convenient operation, has higher performance - price ratio, suitable for the production of many enterprise.%利用绿茶有效成分的水溶性和功效,将绿茶热水浸提液添加到洗发香波中,通过单因素实验和正交实验,得到了绿茶洗发香波的最佳原料配比和制备的工艺流程。通过微生物检测和自愿受试者使用情况的反馈,表明本研究所制的洗发香波不仅能清洗头发、头皮,还具有去屑、止痒、软发、调理等功能的洗发香波。该制备工艺简单、操作方便、性价比高,适合大小工厂、企业的生产。

  2. Study on Magnolia Cream Prescription Screening and Preparation%厚朴乳膏处方筛选及制备工艺的研究与开发

    Institute of Scientific and Technical Information of China (English)

    翁德会; 毛淑芳; 程弘夏; 许腊英

    2015-01-01

    Abstracts:Objective Puepose honokiol components has bactericidal, anti -inflammatory, eliminating dampness, antipruritic effect, through the preparation of cream on the extract was developed using.Methods on the basis of characteristics and cream base of magnolol and honokiol, the prescription composition, screening, and the preparation technology was studied, through the inspection of appearance, the drug transdermal, consistency and stability index, screening the best prescription composition, and preparation of Magnolia officinalis cream. Results Magnolia cream consists of the proportion of preparation, good reproducibility, cream Kizawa Jung, even delicate, consistency is appropriate, easy coating, good stability, absorption through the skin is good, can be regarded as the best proportion to prepare the Magnolia cream.Conclusions It can be used as a new preparation for the development and utilization.%目的:厚朴酚性成分具有杀菌、消炎、燥湿、止痒等作用,通过制备乳膏对其提取物进行开发利用。方法根据厚朴酚、和厚朴酚的特点及乳膏基质的特点,筛选处方组成,并对制备工艺进行研究,通过对乳膏的外观性状、透皮、稠度和稳定性等指标进行考察,筛选最佳的处方组成,并制备厚朴乳膏。结果由该比例的组成制备的厚朴乳膏,重现性好,乳膏色泽较纯正,均匀细腻,稠度适宜,易涂布,稳定性好、透皮吸收等均较好,可以作为最佳配比来制备厚朴乳膏。结论厚朴乳膏可以作为一种新制剂进行开发利用。

  3. The Histamine H4 Receptor: From Orphan to the Clinic

    Directory of Open Access Journals (Sweden)

    Robin L. Thurmond

    2015-03-01

    Full Text Available The histamine H4 receptor (H4R was first noted as a sequence in genomic databases that had features of a G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus became the fourth member of the histamine receptor family. Due to the previous success of drugs that target the H1 and H2 receptors, an effort was made to understand the function of this receptor and determine if it represented a drug target. Taking advantage of the vast literature on histamine, a search for histamine activity that did not appear to be mediated by the other three histamine receptors was undertaken. From this asthma and pruritus emerged as areas of particular interest. Histamine has long been suspected to play a role in the pathogenesis of asthma, but antihistamines that target the H1 and H2 receptors have not been shown to be effective for this condition. The use of selective ligands in animal models of asthma has now potentially filled this gap by showing a role for the H4R in mediating lung function and inflammation. A similar story exists for chronic pruritus associated with conditions such as atopic dermatitis. Antihistamines that target the H1 receptor are effective in reducing acute pruritus, but are ineffective in pruritus experienced by patients with atopic dermatitis. As for asthma, animal models have now suggested a role for the H4R in mediating pruritic responses, with antagonists to the H4R reducing pruritus in a number of different conditions. The anti-pruritic effect of H4R antagonists has recently been shown in human clinical studies, validating the preclinical findings in the animal models. A selective H4R antagonist inhibited histamine-induced pruritus in health volunteers and reduced pruritus in patients with atopic dermatitis. The history to date of the H4R provides an excellent example of the deorphanization of a novel receptor and the translation of this into

  4. In vivo Anti-Inflammatory and Antinociceptive Activities of the Extracts and Chemical Constituents of an Endemic Turkish Plant, Salsola grandis

    Directory of Open Access Journals (Sweden)

    Nurgün Küçükboyacı

    2015-10-01

    Full Text Available Salsola is one of the largest and most important genera in the family Chenopodiaceae. Salsola species are used for their anti-inflammatory, antinociceptive, anthelmintic and antipruritic effects and also as diuretic in traditional medicines worldwide. The aim of the present study is to assess the activity potential of the extracts, subextracts and isolated compounds from the aerial parts of and Salsola grandis, an endemic species in Turkey in a scientific platform. The effects of the extracts, subextracts and isolated compounds were investigated using in vivo experimental models of inflammation and pain in mice, and also total phenolic content of the plant was determined. For the evaluation of the anti-inflammatory activity, carrageenan-induced paw edema and for the assessment of antinociceptive activity, p-benzoquinone-induced nociception tests in mice were employed. The crude ethanol extract of the plant was sequentially fractionated into five subextracts, namely n-hexane, CHCl 3, EtOAc, n-BuOH and remaining water subextracts. Further studies were carried out on the bioactive n -BuOH subextract. Through bioassay-guided fractionation and isolation procedures from active fraction , ten flavonoids, i sorhamnetin-3-O-rutinoside(1, quercetin-3-O-rutinoside (2,quercetin-3-O-metylether (3,tiliroside (4, isorhamnetin-3-glucuronide (5, isorhamnetin-3-O-glucoside (6,quercetin-3-O-galactoside (7, quercetin-3-O-rhamnoside (8,quercetin (9 and manghaslin (10, and two oleanane-type saponins, momordin II b (11 andmomordin II c (12, and one amino acid derivative compound, N-acetyltryptophan (13 were isolated, and their structures were established on the basis of spectroscopic techniques. The anti-inflammatory and antinociceptive activities of 1 , 4, 6, 7 and 12 were investigated firstly in this study, and 4 and 7 were found to have the most potent inhibitory activity in used models. The present study demonstrates the anti-inflammatory and antinociceptive

  5. 厚朴乳膏处方筛选及制备工艺的研究与开发%Study on Magnolia Cream Prescription Screening and Preparation

    Institute of Scientific and Technical Information of China (English)

    翁德会; 毛淑芳; 程弘夏; 许腊英

    2015-01-01

    目的:厚朴酚性成分具有杀菌、消炎、燥湿、止痒等作用,通过制备乳膏对其提取物进行开发利用。方法根据厚朴酚、和厚朴酚的特点及乳膏基质的特点,筛选处方组成,并对制备工艺进行研究,通过对乳膏的外观性状、透皮、稠度和稳定性等指标进行考察,筛选最佳的处方组成,并制备厚朴乳膏。结果由该比例的组成制备的厚朴乳膏,重现性好,乳膏色泽较纯正,均匀细腻,稠度适宜,易涂布,稳定性好、透皮吸收等均较好,可以作为最佳配比来制备厚朴乳膏。结论厚朴乳膏可以作为一种新制剂进行开发利用。%Abstracts:Objective Puepose honokiol components has bactericidal, anti -inflammatory, eliminating dampness, antipruritic effect, through the preparation of cream on the extract was developed using.Methods on the basis of characteristics and cream base of magnolol and honokiol, the prescription composition, screening, and the preparation technology was studied, through the inspection of appearance, the drug transdermal, consistency and stability index, screening the best prescription composition, and preparation of Magnolia officinalis cream. Results Magnolia cream consists of the proportion of preparation, good reproducibility, cream Kizawa Jung, even delicate, consistency is appropriate, easy coating, good stability, absorption through the skin is good, can be regarded as the best proportion to prepare the Magnolia cream.Conclusions It can be used as a new preparation for the development and utilization.

  6. A randomised trial evaluating the effects of the TRPV1 antagonist SB705498 on pruritus induced by histamine, and cowhage challenge in healthy volunteers.

    Directory of Open Access Journals (Sweden)

    Rachel A Gibson

    Full Text Available BACKGROUND: Transient receptor potential vanilloid type 1 (TRPV1 is a non-selective cation channel widely expressed in skin tissues, and peripheral sensory nerve fibres. Activation of TRPV1 releases neuropeptides; the resulting neurogenic inflammation is believed to contribute to the development of pruritus. A TRPV1 antagonist has the potential to perform as an anti-pruritic agent. SB705498 is a TRPV1 antagonist that has demonstrated in vitro activity against cloned TRPV1 human receptors and when orally administered has demonstrated pharmacodynamic activity in animal models and clinical studies. OBJECTIVES: To select a topical dose of SB705498 using the TRPV1 agonist capsaicin; to confirm engagement of the TRPV1 antagonistic action of SB705498 and assess whether the dose selected has an effect on itch induced by two challenge agents. METHODS: A clinical study was conducted in 16 healthy volunteers to assess the effects of 3 doses of SB705498 on skin flare induced by capsaicin. Subjects with a robust capsaicin response were chosen to determine if the selected topical formulation of SB705498 had an effect on challenge agent induced itch. RESULTS: Following capsaicin challenge the greatest average reduction in area of flare was seen for the 3% formulation. This dose was selected for further investigation. Itch intensity induced by two challenge agents (cowhage and histamine was assessed on the Computerised Visual Analogue Scale. The difference in average itch intensity (Weighted Mean Over 15 Mins between the 3% dose of SB705498 and placebo for the cowhage challenge was -0.64, whilst the histamine challenge showed on average a -4.65 point change. CONCLUSIONS: The 3% topical formulation of SB705498 cream was clinically well tolerated and had target specific pharmacodynamic activity. However there were no clinically significant differences on pruritus induced by either challenge agent in comparison to placebo. SB705498 is unlikely to be of symptomatic

  7. Study on Pharmacological Action of Aqueous Extract from Melaleuca Ahemifolia%互叶白千层水提物药理作用研究*

    Institute of Scientific and Technical Information of China (English)

    李燕婧; 钟正贤; 林霄; 刘布鸣

    2013-01-01

      目的:观察互叶白千层水提物的药理作用。方法:采用巴豆油致小鼠耳廓肿胀法、微量2倍稀释法、小鼠热板法、小鼠被动皮肤过敏试验、豚鼠磷酸组胺致痒试验等试验方法观察互叶白千层水提物的药理作用,并对其进行急性毒性试验。结果:互叶白千层水提物能抑制巴豆油引起小鼠耳廓肿胀;提高小鼠热刺激疼痛的痛阈值;对金黄色葡萄球菌、表皮葡萄球菌、大肠埃希杆菌、白色念珠菌有较强抑菌作用;抑制小鼠被动皮肤通透性;增加豚鼠耐受磷酸组胺的致痒阈;互叶白千层水提物的最大给药量为225.62 g生药/kg。结论:互叶白千层水提物具有抗炎、镇痛、抗菌、抗过敏、止痒等药理作用,且毒性小。%Objective: To observe the pharmacological action of aqueous extract from Melaleuca Ahemifolia. Methods: The experiments concluded mice ear-swollen induced by croton oil, double broth dilution method, hot plate test, passive cutaneous anaphylaxis (PCA)in mouse, cavy itch test by histamine phosphate and acute toxicity test to observe the pharmacological action of aqueous extract from Melaleuca Ahemifolia. Results: Aqueous Extract from Melaleuca Ahemifolia can inhibit the mice ear-swollen induced by croton oil, enhance the threshold of pain in mice due to hot stimulation, provide obvious bacteriostatic ac-tion on staphylococcus aureus, staphylococcus epidermidis, bacillus coli and albicans Saccharomyces, reduce the PCA and im-prove cavy itch-threshold by histamine phosphate. The acute toxicity test showed that maximum tolerance of water extract of melaleuca alternifolia was 225.62 g crude drug/kg. Conclusion: Aqueous Extract from Melaleuca Ahemifolia can provide obvious anti-inflammatory, analgesic, antimicrobial, anti-allergic and antipruritic effects, with low toxicity.

  8. Butyl flufenamate ointment in the treatment of solar dermatitis: a clinical observation%氟芬那酸丁酯软膏治疗日光皮炎的临床观察

    Institute of Scientific and Technical Information of China (English)

    杨素清; 安月鹏; 闫景东

    2014-01-01

    目的 探讨氟芬那酸丁酯软膏治疗日光皮炎的疗效及安全性.方法 日光皮炎患者64例,随机分为观察组和对照组,每组32例.观察组外用氟芬那酸丁酯软膏,对照组外用双氯芬酸钠乳膏,疗程为3周.采用疾病情况评分和瘙痒视觉模拟评分比较氟芬那酸丁酯软膏和双氯芬酸乳膏的疗效.结果 观察组临床痊愈4例,显效19例,有效7例,无效2例,总有效率93.8%;对照组临床痊愈2例,显效11例,有效14例,无效5例,总有效率84.4%.观察组总有效率高于对照组,两者差异有统计学意义(P<0.05).从瘙痒评分构成比来看,观察组瘙痒评分显著低于对照组,两者差异有统计学意义(P<0.05).结论 氟芬那酸丁酯治疗日光皮炎疗效优于双氯芬酸,能较好地改善患者瘙痒症状.%Objective To evaluate the efficacy and safety of butyl flufenamate ointment for the treatment of solar dermatitis.Methods Sixty-four patients with solar dermatitis were randomly divided into the observation group (n =32) and control group (n =32) to topically apply butyl flufenamate ointment and diclofenac sodium cream,respectively,for 3 weeks.The efficacy was evaluated by lesion scores and a visual analog scale for pruritus.Results At the end of the treatment,4 patients in the observation group were clinically cured,19 markedly improved,17 improved,and 2 showed no improvement; meanwhile,2 patients in the control group were clinically cured,11 markedly improved,14 improved,and 5 showed no improvement.The total response rate was significantly higher (93.8% vs.84.4%,P < 0.05),while the pruritus score was significantly lower (P < 0.05) in the observation group than in the control group.Conclusion Butyl flufenamate ointment is superior to dicofenac sodium cream in terms of both efficacy and anti-pruritic effect.

  9. Study on the literature information of laws of medication about sores per-ifocal area%基于文献整理的疮疡四畔用药规律研究

    Institute of Scientific and Technical Information of China (English)

    张幼雯; 刘明

    2015-01-01

    Objective To explore suitable for the herbs and external treatment prescriptions of sores perifocal area, based on the modern traditional Chinese medicine surgical literature information. Methods Taking"Superstar electronic books database"and"China Journal of Traditional Chinese Medicine Database"as an information platform, drug databas-es of sores perifocal area was built. The laws of medication about sores perifocal was discussed by data mining of fre-quency analysis, cluster analysis. Results Through sorting 237 literatures, according to the frequency in descending or-der, the frequency of the top 10 herbal medicine were cortex phellodendri, borneol, rhubarb, radix angelica dahurica, calomel, dragon's blood, angelica, frankincense, sesame oil, coptis, which showed that the drug use was concentrated;the main class was antipyretic drugs, blood circulation drugs. Supporting role was played by poison attack insect an-tipruritic drug, purgating drug, resuscitation drugs; cluster analysis resulted that five categories of external treatment prescriptions were represented for Jinhuangsan and Wuweixiaoduyin. Conclusion The base herbs are antipyretic drugs, blood circulation drugs. Jinhuangsan and Wuweixiaoduyin represent for external treatment prescriptions. Through data mining techniques, overall grasps the drug laws of sores perifocal area provides the basis for clinical research.%目的:基于现代中医外科文献,探讨适用于疮疡四畔的常用药物及外治方剂。方法以“超星电子图书数据库”和“中国中医药期刊数据库”作为信息平台,建立疮疡四畔外治药物数据库,应用频数分析、聚类分析等挖掘疮疡四畔的潜方用药规律。结果通过对237篇文献的整理,使用频数最多的前10味药物,按频率递减顺序排列分别为黄柏、冰片、大黄、白芷、轻粉、血竭、当归、乳香、麻油、黄连,可见文献中的药物使用比较集中;主要药类为清热药

  10. 胡椒醇提物的药理学实验研究%Experimental Study of Alcohol Extract from Pepper on Pharmacology

    Institute of Scientific and Technical Information of China (English)

    邓永坤; 董寿堂; 王银辉; 李辉

    2009-01-01

    Objective To investigate the pharmacological effect of alcohol extract from pepper on topical application. Methods Two experimental models including xylene - induced ear edema in mice and histamine phosphate induced - foot pruritus in guinea pigs were employed to evaluate topically anti-inflammatory and antipruritic action of 70% alcohol extract from pepper. Internal diameters of auric arterioles and venules in mice were measured initially and then 5,10 and 20min after application of 70% alcohol extract from pepper and again 5,10,15 and 20 min after ip Adrenaline with image analysis system. Simultaneously blood flow state in auric venules was observed. Results Topical administration of 70% alcohol extract from pepper significantly inhibited ear edema induced by xylene, significantly increased threshold quantity of histamine phosphate with which elicited pruritus in guinea pigs, significantly dilated auric arterioles and venules in mice, speeded up blood flow rate of venules. Furthermore, it inhibited adrenaline - induced contraction of arterioles and venules as well as the reduction of blood flow rate of venules. Conclusion 70% alcohol extract of pepper has pharmacological activities of anti-inflammation, alleviating itching and improving micro-circulation.%目的 探讨胡椒醇提物局部外涂的药理作用.方法 分别采用二甲苯致小鼠耳廓肿胀炎症模型和磷酸组胺致豚鼠足部瘙痒模型测试胡椒70%乙醇提取液的局部抗炎止痒作用;利用图像分析系统测定小鼠耳廓局部应用胡椒70%乙醇提取液前与应用后5,10,20 min及腹腔注射肾上腺素后5,10,15,20 min耳廓细动、静脉口径和细静脉血流态,由此评价其对小鼠耳廓正常微循环和肾上腺素引起的微循环障碍的作用.结果 胡椒70%乙醇提取液局部外涂能显著抑制二甲苯所致小鼠耳廓肿胀;显著提高豚鼠足部磷酸组胺致痒阈;显著增加正常小鼠细动、静脉口径及细静脉血流速度,并

  11. 甲钴胺注射液联合组合型人工肾治疗尿毒症皮肤瘙痒疗效观察%Curative effect of mecobalamin jnjection combined with assembled artificial kidney in treatment of uremic pruritus

    Institute of Scientific and Technical Information of China (English)

    伏广浩; 刘晓东

    2014-01-01

    Objective To observe the effect of mecobalamin injection combined with assembled artificial kidney in uremic pruritus. Methods A total of 38 patients with uremia keeping hemodialysis from January 2009 to January 2012 were randomly divid_ed into the treatment group and the control group,19 cases in each group. The control group was received routine hemodialysis treat_ment,as well as oral antihistamines,sedation antipruritic drugs topical. The treatment group was treated with hemoperfusion (assem_bled artificial kidney) and mecobalamin. The two groups were observed before and 8 weeks after treatment on serum calcium ,phos phorus and intact parathyroid hormone iPTH;β2_microglobulin(β2_MG) and pruritus score changes. Results Compared with the treatment group before the treatment the control group after treatment,serum phosphorus,iPTH,β2_MG,pruritus score decreased,the difference was statistically significant(P<0.05). Conclusion Mecobalamin injection joint combined type artificial kidney may relieve uremic pruritus symptom,reduce serum phosphorus,iPTH andβ2_MG.%目的:观察甲钴胺注射液联合组合型人工肾对尿毒症皮肤瘙痒的疗效。方法2009年1月至2012年1月选择该院行维持性血液透析并出现严重皮肤瘙痒的尿毒症患者38例,随机分为对照组和治疗组,各19例。对照组予常规血液透析治疗,口服抗组胺药、镇静及外用止痒药等一般治疗。治疗组在对照组基础上加用血液灌流(即组合型人工肾)及甲钴胺治疗,观察两组患者治疗前及治疗8周后血钙、磷、全段甲状旁腺激素(iPTH)、β2_微球蛋白(β2_MG)及皮肤瘙痒评分变化情况。结果治疗组治疗后与治疗前及对照组治疗后比较,血磷、iPTH、β2_MG、皮肤瘙痒评分均下降,差异均有统计学意义(P<0.05)。结论甲钴胺注射液联合组合型人工肾可减轻尿毒症皮肤瘙痒症状,降低血磷、iPTH和β2_MG。

  12. An open, self-controlled study on the efficacy of topical indoxacarb for eliminating fleas and clinical signs of flea-allergy dermatitis in client-owned dogs in Queensland, Australia

    Science.gov (United States)

    Fisara, Petr; Sargent, Roger M; Shipstone, Michael; von Berky, Andrew; von Berky, Janet

    2014-01-01

    Background Canine flea-allergy dermatitis (FAD), a hypersensitivity response to antigenic material in the saliva of feeding fleas, occurs worldwide and remains a common presentation in companion animal veterinary practice despite widespread availability of effective systemic and topical flea-control products. Hypothesis/Objectives To evaluate the clinical response in dogs with FAD treated topically with indoxacarb, a novel oxadiazine insecticide. Animals Twenty-five client-owned dogs in Queensland, Australia diagnosed with pre-existing FAD on the basis of clinical signs, flea-antigen intradermal and serological tests. Methods An open-label, noncontrolled study, in which all dogs were treated with topical indoxacarb at 4 week intervals, three times over 12 weeks. Results Twenty-four dogs completed the study. Complete resolution of clinical signs of FAD was observed in 21 cases (87.5%), with nearly complete resolution or marked improvement in the remaining three cases. Mean clinical scores (Canine Atopic Dermatitis Extent and Severity Index-03) were reduced by 93.3% at week 12. Mean owner-assessed pruritus scores were reduced by 88% by week 12. Mean flea counts reduced by 98.7 and 100% in weeks 8 and 12, respectively. Conclusions and clinical importance Topical indoxacarb treatment applied every 4 weeks for 12 weeks, without concomitant antipruritic or ectoparasiticide therapy, completely alleviated flea infestations in all dogs and associated clinical signs of FAD in a high proportion of this population of dogs in a challenging flea-infestation environment. Résumé Contexte La dermatite par allergie aux piqures de puces (FAD), une hypersensibilité aux antigènes salivaires des puces, est décrite dans le monde entier et reste une présentation fréquente en médicine vétérinaire des animaux de compagnie malgré une large gamme d'antiparasitaires topiques et systémiques efficaces disponibles. Hypothèses/Objectifs Estimer la réponse clinique des chiens