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Sample records for ankara vectors enhances

  1. Vectores recombinantes basados en el virus Vaccinia modificado de Ankara (MVA) como vacunas contra la leishmaniasis

    OpenAIRE

    Pérez Jiménez, Eva; Larraga, Vicente; Esteban, Mariano

    2005-01-01

    Vectores recombinantes basados en el virus vaccinia modificado de Ankara (MVA) como vacunas contra la leishmaniasis. Los vectores de la invención contienen secuencias codificantes de la proteína LACK, preferentemente insertadas en el locus de hemaglutinina del virus y bajo el control de un promotor que permite su expresión a lo largo del ciclo de infección del virus. Son vectores seguros, estables, que dan lugar a una potente respuesta inmune que confiere protección frente a la leishmaniasis,...

  2. Cross-protective immunity against multiple influenza virus subtypes by a novel modified vaccinia Ankara (MVA) vectored vaccine in mice.

    Science.gov (United States)

    Brewoo, Joseph N; Powell, Tim D; Jones, Jeremy C; Gundlach, Nancy A; Young, Ginger R; Chu, Haiyan; Das, Subash C; Partidos, Charalambos D; Stinchcomb, Dan T; Osorio, Jorge E

    2013-04-01

    Development of an influenza vaccine that provides cross-protective immunity remains a challenge. Candidate vaccines based on a recombinant modified vaccinia Ankara (MVA) viral vector expressing antigens from influenza (MVA/Flu) viruses were constructed. A vaccine candidate, designated MVA/HA1/C13L/NP, that expresses the hemagglutinin from pandemic H1N1 (A/California/04/09) and the nucleoprotein (NP) from highly pathogenic H5N1 (A/Vietnam/1203/04) fused to a secretory signal sequence from vaccinia virus was highly protective. The vaccine elicited strong antibody titers to homologous H1N1 viruses while cross-reactive antibodies to heterologous viruses were not detectable. In mice, this MVA/HA1/C13L/NP vaccine conferred complete protection against lethal challenge with A/Vietnam/1203/04 (H5N1), A/Norway/3487-2/09 (pandemic H1N1) or A/Influenza/Puerto Rico/8/34 (seasonal H1N1) and partial protection (57.1%) against challenge with seasonal H3N2 virus (A/Aichi/68). The protective efficacy of the vaccine was not affected by pre-existing immunity to vaccinia. Our findings highlight MVA as suitable vector to express multiple influenza antigens that could afford broad cross-protective immunity against multiple subtypes of influenza virus. PMID:23376279

  3. Immunological characterization of a modified vaccinia virus Ankara vector expressing the human papillomavirus 16 E1 protein.

    Science.gov (United States)

    Remy-Ziller, Christelle; Germain, Claire; Spindler, Anita; Hoffmann, Chantal; Silvestre, Nathalie; Rooke, Ronald; Bonnefoy, Jean-Yves; Préville, Xavier

    2014-02-01

    Women showing normal cytology but diagnosed with a persistent high-risk human papillomavirus (HR-HPV) infection have a higher risk of developing high-grade cervical intraepithelial neoplasia and cervical cancer than noninfected women. As no therapeutic management other than surveillance is offered to these women, there is a major challenge to develop novel targeted therapies dedicated to the treatment of these patients. As such, E1 and E2 antigens, expressed early in the HPV life cycle, represent very interesting candidates. Both proteins are necessary for maintaining coordinated viral replication and gene synthesis during the differentiation process of the epithelium and are essential for the virus to complete its normal and propagative replication cycle. In the present study, we evaluated a new active targeted immunotherapeutic, a modified vaccinia virus Ankara (MVA) vector containing the E1 sequence of HPV16, aimed at inducing cellular immune responses with the potential to help and clear persistent HPV16-related infection. We carried out an extensive comparative time course analysis of the cellular immune responses induced by different schedules of immunization in C57BL/6 mice. We showed that multiple injections of MVA-E1 allowed sustained HPV16 E1-specific cellular immune responses in vaccinated mice and had no impact on the exhaustion phenotype of the generated HPV16 E1-specific CD8⁺ T cells, but they led to the differentiation of multifunctional effector T cells with high cytotoxic capacity. This study provides proof of concept that an MVA expressing HPV16 E1 can induce robust and long-lasting E1-specific responses and warrants further development of this candidate. PMID:24307238

  4. Vectores recombinantes basados en el virus modificado de ankara (MVA) como vacunas preventivas y terapéuticas contra el SIDA

    OpenAIRE

    Jonathan L Heeney; Mooij, Petra; Nájera García, José Luis; Jiménez, Victoria; Esteban, Mariano; Gómez, Carmen E.

    2005-01-01

    Vectores Recombinantes basados en el Virus Modificado de Ankara (MVA) como Vacunas Preventivas y Terapéuticas contra el SIDA. Losvirus recombinantes de la invención contienen secuencias que se encuentran insertadas en el mismo sitio de inserción del MVA y permiten la expresión simultánea de varios antígenos, una proteína Env del VIH-I consistente en una proteína gpl20 carente de secuencias correspondientes a la proteína gp41, y una proteína quiméricade fusión de Gag, Pol y Nef. Son virus esta...

  5. Safety and tolerability of conserved region vaccines vectored by plasmid DNA, simian adenovirus and modified vaccinia virus ankara administered to human immunodeficiency virus type 1-uninfected adults in a randomized, single-blind phase I trial.

    Directory of Open Access Journals (Sweden)

    Emma-Jo Hayton

    Full Text Available TRIAL DESIGN: HIV-1 vaccine development has advanced slowly due to viral antigenic diversity, poor immunogenicity and recently, safety concerns associated with human adenovirus serotype-5 vectors. To tackle HIV-1 variation, we designed a unique T-cell immunogen HIVconsv from functionally conserved regions of the HIV-1 proteome, which were presented to the immune system using a heterologous prime-boost combination of plasmid DNA, a non-replicating simian (chimpanzee adenovirus ChAdV-63 and a non-replicating poxvirus, modified vaccinia virus Ankara. A block-randomized, single-blind, placebo-controlled phase I trial HIV-CORE 002 administered for the first time candidate HIV-1- vaccines or placebo to 32 healthy HIV-1/2-uninfected adults in Oxford, UK and elicited high frequencies of HIV-1-specific T cells capable of inhibiting HIV-1 replication in vitro. Here, detail safety and tolerability of these vaccines are reported. METHODS: Local and systemic reactogenicity data were collected using structured interviews and study-specific diary cards. Data on all other adverse events were collected using open questions. Serum neutralizing antibody titres to ChAdV-63 were determined before and after vaccination. RESULTS: Two volunteers withdrew for vaccine-unrelated reasons. No vaccine-related serious adverse events or reactions occurred during 190 person-months of follow-up. Local and systemic events after vaccination occurred in 27/32 individuals and most were mild (severity grade 1 and predominantly transient (<48 hours. Myalgia and flu-like symptoms were more strongly associated with MVA than ChAdV63 or DNA vectors and more common in vaccine recipients than in placebo. There were no intercurrent HIV-1 infections during follow-up. 2/24 volunteers had low ChAdV-63-neutralizing titres at baseline and 7 increased their titres to over 200 with a median (range of 633 (231-1533 post-vaccination, which is of no safety concern. CONCLUSIONS: These data demonstrate

  6. Split-intron retroviral vectors: enhanced expression with improved safety.

    Science.gov (United States)

    Ismail, S I; Kingsman, S M; Kingsman, A J; Uden, M

    2000-03-01

    The inclusion of retrovirus-derived introns within retrovirus-based expression vectors leads to a fraction of the resulting transcripts being spliced. Such splicing has been shown to markedly improve expression (W. J. Krall et al., Gene Ther. 3:37-48, 1996). One way to improve upon this still further might involve the use of more efficient introns instead of those from the provirus. Currently, however, incorporation of such introns remains self-defeating since they are removed in the nucleus of the producer cell. In the past, elaborate ways to overcome this problem have included the use of alphaviruses to make the vector transcripts within the cytoplasm, thus avoiding the nuclear splicing machinery during vector production (K. J. Li and H. Garoff, Proc. Natl. Acad. Sci. USA 95:3650-3654, 1998). We now present a novel design for the inclusion of introns within a retroviral vector. In essence, this is achieved by exploiting the retroviral replication process to copy not only the U3 promoter but also a synthetic splice donor to the 5'-long-terminal-repeat position during reverse transcription. Once copied, synthesized transcripts then contain a splice donor at their 5' end capable of interacting with a consensus splice acceptor engineered downstream of the packaging signal. Upon transduction, we demonstrate these vectors to produce enhanced expression from near fully spliced (and thus packaging signal minus) transcripts. The unique design of these high titer and high-expression retroviral vectors may be of use in a number of gene therapy applications. PMID:10666267

  7. Recombinant modified vaccinia virus Ankara-based malaria vaccines.

    Science.gov (United States)

    Sebastian, Sarah; Gilbert, Sarah C

    2016-01-01

    A safe and effective malaria vaccine is a crucial part of the roadmap to malaria elimination/eradication by the year 2050. Viral-vectored vaccines based on adenoviruses and modified vaccinia virus Ankara (MVA) expressing malaria immunogens are currently being used in heterologous prime-boost regimes in clinical trials for induction of strong antigen-specific T-cell responses and high-titer antibodies. Recombinant MVA is a safe and well-tolerated attenuated vector that has consistently shown significant boosting potential. Advances have been made in large-scale MVA manufacture as high-yield producer cell lines and high-throughput purification processes have recently been developed. This review describes the use of MVA as malaria vaccine vector in both preclinical and clinical studies in the past 5 years. PMID:26511884

  8. Periodic Excitation for Jet Vectoring and Enhanced Spreading

    Science.gov (United States)

    Pack, LaTunia G.; Seifert, Avi

    1999-01-01

    The effects of periodic excitation on the evolution of a turbulent jet were studied experimentally. A short, wide-angle diffuser was attached to the jet exit and excitation was introduced at the junction between the jet exit and the diffuser inlet. The introduction of high amplitude periodic excitation at the jet exit enhances the mixing and promotes attachment of the jet shear-layer to the diffuser wall. Vectoring is achieved by applying the excitation over a fraction of the circumference of the circular jet, enhancing its spreading rate on the excited side and its tendency to reattach to that side. Static deflection studies demonstrate that the presence of the wide-angle diffuser increases the effectiveness of the added periodic momentum due to a favorable interaction between the excitation, the jet shear-layer and the diffuser wall. This point was further demonstrated by the evolution of a wave packet that was excited in the jet shear-layer. Strong amplification of the wave packet was measured with a diffuser attached to the jet exit. The turbulent jet responds quickly (10-20 msec) to step changes in the level of the excitation input. The response scales with the jet exit velocity and is independent of the Reynolds number. Jet deflection angles were found to be highly sensitive to the relative direction between the excitation and the jet flow and less sensitive to the excitation frequency. The higher jet deflection angles were obtained for a diffuser length of about two diameters and for diffusers with half-angles greater than 15 degrees.

  9. 19th Century Ankara Through Historical Poems

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    Özge Öztekin

    2015-12-01

    Full Text Available A city is a place whose meaning is found in the poetry created there. In Kevin Lynch’s words, a city presents the imagination with an unlimited potential for “readability”. If we consider this unlimited readability through poetry, it can be said that attempts to find the zeitgeist of a city at a certain time through literary texts must evaluate the poetry, the city and the time. This is because poetry (or literature in general, just like a city, has an important memory which oscillates through ideas of its past and future. In this sense, divan poetry and one particular example of it—historical “manzume” poems—are memories which richly illustrate the ‘continuity’ and ‘change’ within a period. This work, on 19th century Ankara, aims to evaluate the traces reflected in historical manzume poems of the time they were written. Five historical manzume poems in three texts out of seventy 19th century divan collections scanned for this work were found to be about Ankara. Two of these manzumes are by Cazib, one by Ziver Pasha, and one by Mahmud Celaleddin Pasha. The first of these is on Ankara’s dervish lodge; the second on a barracks being built in Ankara; the third on Vecihi Pasha’s governorship of Ankara; the fourth on the the Mayoral Residence. In addition to these, a manzume on the construction of Hamidiye Caddesi by Mahmud Celaleddin Pasha is discovered with in scope of the work. The aim of this work is to provide a contribution to city history through a commentary on elements of 19th century poetry concerning Ankara.

  10. A Photographer From Ankara: Osman Darcan

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    Gülseren Mungan Yavuztürk

    2015-12-01

    Full Text Available This work introduces Osman Darcan, an important name in the history of Ankara photography studios. Darcan followed in the footsteps of famous Austrian photographer Othmar Pferschy, whom he met in Istanbul, to go on to create his own valuable work. On leaving the Public Press Authority Photo Film Center, where he worked as a newsreel photographer and film operator, in 1943 he began taking photographs at the Tatbikat Theater at the Ankara State Conservatoire, where he continued as the photographer for the State Theater until the end of his life. At the same time, this master photographer took the pictures of a select coterie of Ankara’s leading individuals and well-known performers at a studio he opened on Anafartalar Caddesi. In both these roles, his photographs evoke admiration thanks to Darcan’s professional abilities and level of artistry.

  11. Split-Intron Retroviral Vectors: Enhanced Expression with Improved Safety

    OpenAIRE

    Ismail, Said I.; Kingsman, Susan M.; Kingsman, Alan J.; Uden, Mark

    2000-01-01

    The inclusion of retrovirus-derived introns within retrovirus-based expression vectors leads to a fraction of the resulting transcripts being spliced. Such splicing has been shown to markedly improve expression (W. J. Krall et al., Gene Ther. 3:37–48, 1996). One way to improve upon this still further might involve the use of more efficient introns instead of those from the provirus. Currently, however, incorporation of such introns remains self-defeating since they are removed in the nucleus ...

  12. Enhancer sequences of a retroviral vector determine expression of a gene in multipotent hematopoietic progenitors and committed erythroid cells.

    OpenAIRE

    Holland, C A; Anklesaria, P; Sakakeeny, M A; Greenberger, J.S.

    1987-01-01

    To analyze the transcriptional activity of retroviral enhancer sequences in hematopoietic lineages, we determined the effect of enhancer sequences on the expression of the neomycin resistance gene transferred by two retroviral vectors to primary hematopoietic lineages. We constructed the vector pFr-SV(X). The Moloney murine leukemia virus enhancer region of a vector, pZIP-SV(X), was replaced by a 380-nucleotide-long fragment containing the enhancer sequences of the Friend murine leukemia viru...

  13. Metrics for vector quantization-based parametric speech enhancement and separation

    DEFF Research Database (Denmark)

    Christensen, Mads Græsbøll

    2013-01-01

    Speech enhancement and separation algorithms sometimes employ a two-stage processing scheme, wherein the signal is first mapped to an intermediate low-dimensional parametric description after which the parameters are mapped to vectors in codebooks trained on, for exam- ple, individual noise......-free sources using a vector quantizer. To obtain accurate parameters, one must employ a good estimator in finding the parameters of the intermediate representation, like a maximum like- lihood estimator. This leaves some unanswered questions, however, like what metrics to use in the subsequent vector...

  14. Use of intron-disrupted polyadenylation sites to enhance expression and safety of retroviral vectors.

    Science.gov (United States)

    Ismail, S I; Rohll, J B; Kingsman, S M; Kingsman, A J; Uden, M

    2001-01-01

    Normal mRNA polyadenylation signals are composed of an AAUAAA motif and G/U box spaced 20 to 30 bp apart. If this spacing is increased further, then polyadenylation is disrupted. Previously it has been demonstrated that insertion of an intron will similarly disrupt this signal even though such introns are removed during a nuclear splicing reaction (X. Liu and J. Mertz, Nucleic Acids Res. 21:5256-5263, 1993). This observation has led to the suggestion that polyadenylation site selection is undertaken prior to intron excision. We now present results that both support and extend these observations and in doing so create a novel class of retroviral expression vector with improved qualities. We found that when an intron-disrupted polyadenylation signal is inserted within a retroviral expression vector, such a signal, although reformed in the producer cell, remains benign until transduction, where it is then preferentially used. Thus, we demonstrate that upon transduction these vectors now produce a majority of shortened subgenomic species and as a consequence have a reduced tendency for subsequent mobilization from transduced cells. In addition, we demonstrate that the use of this internal signal leads to enhanced expression from such vectors and that this is achieved without any loss in titer. Therefore, split polyadenylation signals confer enhanced performance and improved safety upon retroviral expression vectors into which they are inserted. Such split signals may prove useful for the future optimization of retroviral vectors in gene therapy. PMID:11119589

  15. A Novel Naturally Occurring Tandem Promoter in Modified Vaccinia Virus Ankara Drives Very Early Gene Expression and Potent Immune Responses

    OpenAIRE

    Wennier, Sonia T.; Brinkmann, Kay; Steinhäußer, Charlotte; Mayländer, Nicole; Mnich, Claudia; Wielert, Ursula; Dirmeier, Ulrike; Hausmann, Jürgen; Chaplin, Paul; Steigerwald, Robin

    2013-01-01

    Modified vaccinia virus Ankara (MVA) has been shown to be suitable for the generation of experimental vaccines against cancer and infectious diseases, eliciting strong humoral and cellular immune responses. In viral vectored vaccines, strong recombinant antigen expression and timing of expression influence the quantity and quality of the immune response. Screening of synthetic and native poxvirus promoters for strong protein expression in vitro and potent immune responses in vivo led to the i...

  16. Human bioclimatology analysis of Ankara urban area

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    Onur Çalışkan

    2011-10-01

    Full Text Available In this study, the Physiological Equivalent Temperatures (PET of different land patterns in the Ankara urban area has been analyzed. The spatial distribution and temporal variation of the thermal perceptions and the grades of thermal stress caused by the thermal conditions have been determined for 00:00, 03:00, 06:00, 09:00, 12:00, 15:00, 18:00 and 21:00 hours during the December and July of 2010. The effects of physiographic features such as elevation, aspect, slope, and especially land use, on the PETs have also been examined. According to the analysis which is carried out by using PET thermal perception index, in the research area the thermal comfort values varies around from -6 to -11°C in winter and from 13°C to 50°C in summer. In both periods the open spaces (grasslands of the city forests have the maximum PET values during the day. Either in December and in July the urban area (city center has and cool island during the day and has a heat island during the night.

  17. Enhancing the clinical potential of AAV vectors by capsid engineering to evade pre-existing immunity

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    DavidSchaffer

    2011-10-01

    Full Text Available Vectors based on adeno-associated viruses have shown considerable promise in both preclinical models and increasingly in clinical trials. However, one formidable challenge is pre-existing immunity due to widespread exposure to numerous AAV variants and serotypes within the human population, which affect efficacy of clinical trials due to the accompanying high levels of anti-capsid neutralizing antibodies. Transient immunosuppression has promise in mitigating cellular and humoral responses induced by vector application in naïve hosts, but cannot overcome the problem that pre-existing neutralizing antibodies pose towards the goal of safe and efficient gene delivery. Shielding of AAV from antibodies, however, may be possible by covalent attachment of polymers to the viral capsid or by encapsulation of vectors inside biomaterials. In addition, there has been considerable progress in using rational mutagenesis, combinatorial libraries, and directed evolution approaches to engineer capsid variants that are not recognized by anti-AAV antibodies generally present in the human population. While additional progress must be made, such strategies, alone or in combination with immunosuppression to avoid de novo induction of antibodies, have strong potential to significantly enhance the clinical efficacy of AAV vectors.

  18. Detection of urban heat island in Ankara, Turkey

    International Nuclear Information System (INIS)

    Ankara is the second largest city in Turkey after Istanbul, and the rate of population increase and urbanization are quite high. In this study, the effects of urbanization on temperature variation due to urbanization in Ankara were investigated. The intensities of urban heat island (UHI) for long and short term were analyzed. Analysis of both long- and short-term data revealed that there is a significant increase in the intensity of UHI (AT(u-r)) in winter during the period analyzed. Analysis of data collected for period of October 2001-September 2002 shows that intensity of maximum UHI is in February. In this month, positive UHI was observed in 26 nights and on all these days wind speed was less than 0.5ms.1. UHI is positive in all seasons and frequency and intensity of UHI in winter are higher than in the other seasons. This characteristic makes Ankara different from other temperate latitude cities

  19. ENHANCED TIME-DEPENDENT EVOLUTIONARY FUZZY SUPPORT VECTOR MACHINES INFERENCE MODEL FOR CASH FLOW PREDICTION AND ESTIMATE AT COMPLETION

    OpenAIRE

    MIN-YUAN CHENG; YU-WEI WU; LE TRUNG DAN; ANDREAS F. VAN ROY

    2013-01-01

    This study conducts a mechanism enhancing the time series data treatment of the time-dependent evolutionary fuzzy support vector machine inference model (EFSIMT). The enhanced model, EFSIMET, was developed particularly to treat construction management problems that contain time series data. EFSIMET is an artificial intelligent hybrid system in which fuzzy logic (FL) deal with vagueness and approximate reasoning; support vector machine (SVM) acts as supervise learning tool; and fast messy gene...

  20. Fetal muscle gene transfer is not enhanced by an RGD capsid modification to high-capacity adenoviral vectors.

    Science.gov (United States)

    Bilbao, R; Reay, D P; Hughes, T; Biermann, V; Volpers, C; Goldberg, L; Bergelson, J; Kochanek, S; Clemens, P R

    2003-10-01

    High levels of alpha(v) integrin expression by fetal muscle suggested that vector re-targeting to integrins could enhance adenoviral vector-mediated transduction, thereby increasing safety and efficacy of muscle gene transfer in utero. High-capacity adenoviral (HC-Ad) vectors modified by an Arg-Gly-Asp (RGD) peptide motif in the HI loop of the adenoviral fiber (RGD-HC-Ad) have demonstrated efficient gene transfer through binding to alpha(v) integrins. To test integrin targeting of HC-Ad vectors for fetal muscle gene transfer, we compared unmodified and RGD-modified HC-Ad vectors. In vivo, unmodified HC-Ad vector transduced fetal mouse muscle with four-fold higher efficiency compared to RGD-HC-Ad vector. Confirming that the difference was due to muscle cell autonomous factors and not mechanical barriers, transduction of primary myogenic cells isolated from murine fetal muscle in vitro demonstrated a three-fold better transduction by HC-Ad vector than by RGD-HC-Ad vector. We hypothesized that the high expression level of coxsackievirus and adenovirus receptor (CAR), demonstrated in fetal muscle cells both in vitro and in vivo, was the crucial variable influencing the relative transduction efficiencies of HC-Ad and RGD-HC-Ad vectors. To explore this further, we studied transduction by HC-Ad and RGD-HC-Ad vectors in paired cell lines that expressed alpha(v) integrins and differed only by the presence or absence of CAR expression. The results increase our understanding of factors that will be important for retargeting HC-Ad vectors to enhance gene transfer to fetal muscle. PMID:12960972

  1. Surface plasmonic resonance induced near-field vectors and their contribution to quantum dot infrared photodetector enhancement

    International Nuclear Information System (INIS)

    In this paper, we analyse surface plasmonic resonance (SPR) induced near-field electric-field ( E-vector ) vector distribution in the quantum dot (QD) region and determine their roles in quantum dot infrared photodetector (QDIP) enhancement. SPR can be excited in metallic two-dimensional subwavelength hole arrays (2DSHAs) when illuminated at resonant wavelengths. The SPR induced near-field E-vector vectors (Ez, Ex and Ey) and their distributions and overlaps with the QD active region are simulated. A long-wave infrared (LWIR) QDIP is fabricated with the 2DSHA plasmonic structure to experimentally measure the SPR enhancement spectrum and compare it with the near-field vector components and their distribution in QDs. We found that QDIP enhancement is closely related to the near-field intensity overlap integral in the QD region. The large near-field overlap integral corresponds to high QDIP enhancement. Such near-field overlap integral dependent plasmonic enhancement is attributed to the interaction of E-vector and the electric-dipole interaction in QDs. (paper)

  2. Mechanical Vectors Enhance Fungal Entomopathogen Reduction of the Grasshopper Pest Camnula pellucida (Orthoptera: Acrididae).

    Science.gov (United States)

    Kistner, Erica J; Saums, Marielle; Belovsky, Gary E

    2015-02-01

    Mounting scientific evidence indicates that pathogens can regulate insect populations. However, limited dispersal and sensitivity to abiotic conditions often restricts pathogen regulation of host populations. While it is well established that arthropod biological vectors increase pathogen incidence in host populations, few studies have examined whether arthropod mechanical vectors (an organism that transmits pathogens but is not essential to the life cycle of the pathogen) influence host-pathogen dynamics. The importance of mechanical dispersal by ant scavengers, Formica fusca (L.), in a grasshopper-fungal entomopathogen system was investigated. We examined the ability of ants to mechanically disperse and transmit the pathogen, Entomophaga grylli (Fresenius) pathotype 1, to its host, the pest grasshopper Camnula pellucida (Scudder), in a series of laboratory experiments. Fungal spores were dispersed either externally on the ant's body surface or internally through fecal deposition. In addition, a third of all grasshoppers housed with fungal-inoculated ants became infected, indicating that ants can act as mechanical vectors of E. grylli. The effect of ant mechanical vectors on E. grylli incidence was also examined in a field experiment. Ant access to pathogen-exposed experimental grasshopper populations was restricted using organic ant repellent, thereby allowing us to directly compare mechanical and natural transmission. Ants increased grasshopper pathogen mortality by 58%, which led to greater pathogen reductions of grasshopper survival than natural transmission. Taken together, our results indicate that ants enhance E. grylli reduction of grasshopper pest numbers. Therefore, mechanical transmission of pathogens may be an important overlooking component of this grasshopper-fungal pathogen system. PMID:26308817

  3. A Hybridization of Enhanced Artificial Bee Colony-Least Squares Support Vector Machines for Price Forecasting

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    Yuhanis Yusof

    2012-01-01

    Full Text Available Problem statement: As the performance of Least Squares Support Vector Machines (LSSVM is highly rely on its value of regularization parameter, γ and kernel parameter, σ2, man-made approach is clearly not an appropriate solution since it may lead to blindness in certain extent. In addition, this technique is time consuming and unsystematic, which consequently affect the generalization performance of LSSVM. Approach: This study presents an enhanced Artificial Bee Colony (ABC to automatically optimize the hyper parameters of interest. The enhancement involved modifications that provide better exploitation activity by the bees during searching and prevent premature convergence. Later, the prediction process is accomplished by LSSVM. Results and Conclusion: Empirical results obtained indicated that feasibility of proposed technique showed a satisfactory performance by producing better prediction accuracy as compared to standard ABC-LSSVM and Back Propagation Neural Network.

  4. Blood Parasites of Wild Pigeons in Ankara District

    OpenAIRE

    GICIK, Yunus; ARSLAN, M. Özkan

    2001-01-01

    A total of 200 wild pigeons, 82 young and 118 adults, captured from 12 localities in Ankara District, were examined for blood parasites. Haemoproteus columbae was found in 57% (114/200) of the pigeons examined, and no other blood parasites were detected.

  5. Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA)

    DEFF Research Database (Denmark)

    Cottingham, Matthew G; Andersen, Rikke F; Spencer, Alexandra J;

    2008-01-01

    infectious virus using a Fowlpox virus helper to supply transcriptional machinery. We apply here a similar approach to the attenuated strain Modified Vaccinia virus Ankara (MVA), now widely used as a safe non-replicating recombinant vaccine vector in mammals, including humans. Four apparently full...... using GalK counterselection to insert an antigen expression cassette lacking a tandem marker gene into the traditional thymidine kinase locus of MVA-BAC. MVA continues to feature prominently in clinical trials of recombinant vaccines against diseases such as HIV-AIDS, malaria and tuberculosis. Here we...

  6. Oral vaccination with modified vaccinia virus Ankara attached covalently to TMPEG-modified cationic liposomes overcomes pre-existing poxvirus immunity from recombinant vaccinia immunization

    OpenAIRE

    Naito, Toshio; Kaneko, Yutaro; Kozbor, Danuta

    2007-01-01

    Development of a safe and effective vaccine for induction of mucosal immunity to the human immunodeficiency virus (HIV) envelope glycoprotein (Env, gp160) represents the best hope for containing the spread of an HIV epidemic worldwide. The highly attenuated modified vaccinia virus Ankara (MVA) is a laboratory virus well suited as a safe vaccine vector. However, the presence of pre-existing immunity to Vaccinia virus in the adult population represents a hindrance that limits the application of...

  7. A Class of Nonlocal Variational Problems on a Vector Bundle for Color Image Local Contrast Reduction/Enhancement.

    OpenAIRE

    Batard, Thomas; Bertalmío, Marcelo

    2016-01-01

    We extend two existing variational models from the Euclidean space to a vector bundle over a Riemannian manifold. The Euclidean models , dedicated to regularize or enhance some color image features, are based on the concept of nonlocal gradient operator acting on a function of the Euclidean space. We then extend these models by generalizing this operator to a vector bundle over a Riemannian manifold with the help of the parallel transport map associated to some class of covariant derivatives....

  8. Utilizing Conceptual Indexing to Enhance the Effectiveness of Vector Space Model

    Directory of Open Access Journals (Sweden)

    Aya M. Al-Zoghby

    2013-10-01

    Full Text Available One of the main purposes of the semantic Web is to improve the retrieval performance of search systems. Unlike keyword based search systems, the semantic search systems aim to discover pages related to the query's concepts rather than merely collecting all pages instantiating its keywords. To that end, the concepts must be defined to be used as a semantic index instead of the traditional lexical one. In fact, The Arabic language is still far from being semantically searchable. Therefore, this paper proposed a model that exploits the Universal Word Net ontology for producing an Arabic Concepts-Space to be used as the index of Semantic Vector Space Model. The Vector Space Model is one of the most common information retrieval models due to its capability of expressing the documents' structure. However, like all keyword-based search systems, its sensitivity to the query's keywords reduces its retrieval effectiveness. The proposed model allows the VSM to represent Arabic documents by their topic, and thus classify them semantically. This, consequently, enhances the retrieval effectiveness of the search system.

  9. Using support vector machine and dynamic parameter encoding to enhance global optimization

    Science.gov (United States)

    Zheng, Z.; Chen, X.; Liu, C.; Huang, K.

    2016-05-01

    This study presents an approach which combines support vector machine (SVM) and dynamic parameter encoding (DPE) to enhance the run-time performance of global optimization with time-consuming fitness function evaluations. SVMs are used as surrogate models to partly substitute for fitness evaluations. To reduce the computation time and guarantee correct convergence, this work proposes a novel strategy to adaptively adjust the number of fitness evaluations needed according to the approximate error of the surrogate model. Meanwhile, DPE is employed to compress the solution space, so that it not only accelerates the convergence but also decreases the approximate error. Numerical results of optimizing a few benchmark functions and an antenna in a practical application are presented, which verify the feasibility, efficiency and robustness of the proposed approach.

  10. Enhancement of third harmonic generation by wave vector mismatch to counter phase-modulation

    Science.gov (United States)

    Trippenbach, M.; Matuszewski, M.; Infeld, E.; Long Van, Cao; Tasgal, R. S.; Band, Y. B.

    2004-01-01

    Recent experimental developments in material sciences have generated hope that it will be possible to devise optical media where the difference in group velocity between the fundamental and third harmonic may be strongly suppressed. Under these circumstances both pulses would travel together over a long distance. This would lead to an enhancement of the generation process, and hence strong focusing and/or using ultra-short pulses might not be crucial. If the perfect phase matching condition is assumed, the only remaining mechanisms to decrease efficiency are self and cross phase modulation. Here we suggest that, instead of exactly matching wave vectors, we admit a small mismatch and show how it can be tailored to compensate for the cross phase modulation of the third harmonic by the fundamental during the generation process. This is very beneficial for the efficiency of third harmonic generation, even increasing it by a factor of two or more.

  11. Enhancement of Mucosal Immunogenicity of Viral Vectored Vaccines by the NKT Cell Agonist Alpha-Galactosylceramide as Adjuvant

    Directory of Open Access Journals (Sweden)

    Shailbala Singh

    2014-10-01

    Full Text Available Gene-based vaccination strategies, specifically viral vectors encoding vaccine immunogens are effective at priming strong immune responses. Mucosal routes offer practical advantages for vaccination by ease of needle-free administration, and immunogen delivery at readily accessible oral/nasal sites to efficiently induce immunity at distant gut and genital tissues. However, since mucosal tissues are inherently tolerant for induction of immune responses, incorporation of adjuvants for optimal mucosal vaccination strategies is important. We report here the effectiveness of alpha-galactosylceramide (α-GalCer, a synthetic glycolipid agonist of natural killer T (NKT cells, as an adjuvant for enhancing immunogenicity of vaccine antigens delivered using viral vectors by mucosal routes in murine and nonhuman primate models. Significant improvement in adaptive immune responses in systemic and mucosal tissues was observed by including α-GalCer adjuvant for intranasal immunization of mice with vesicular stomatitis virus vector encoding the model antigen ovalbumin and adenoviral vectors expressing HIV env and Gag antigens. Activation of NKT cells in systemic and mucosal tissues along with significant increases in adaptive immune responses were observed in rhesus macaques immunized by intranasal and sublingual routes with protein or adenovirus vectored antigens when combined with α-GalCer adjuvant. These results support the utility of α-GalCer adjuvant for enhancing immunogenicity of mucosal vaccines delivered using viral vectors.

  12. Characteristic element of matrix attachment region mediates vector attachment and enhances nerve growth factor expression in Chinese hamster ovary cells.

    Science.gov (United States)

    Wang, X Y; Zhang, J H; Sun, Q L; Yao, Z Y; Deng, B G; Guo, W Y; Wang, L; Dong, W H; Wang, F; Zhao, C P; Wang, T Y

    2015-01-01

    Preliminary studies have suggested that a characteristic element of the matrix attachment region (MAR) in human interferon-β mediates the adhesion of vectors to Chinese hamster ovary (CHO) cells. In this study, we investigated if vector adhesion increased nerve growth factor (NGF) expression in CHO cells. The MAR characteristic element sequence of human interferon-β was inserted into the multiple-cloning site of the pEGFP-C1 vector. The target NGF gene was inserted upstream of the MAR characteristic element sequence to construct the MAR/NGF expression vector. The recombinant plasmid was transfected into CHO cells and stable monoclonal cells were selected using G418. NGF mRNA and protein expression was detected by reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Plasmid reduction experiments were used to determine the state of transfected plasmid in mammalian cells. The insertion of MAR into the vector increased NGF expression levels in CHO cells (1.93- fold) compared to the control. The recombinant plasmid expressing the MAR sequence was digested into a linear space vector. The inserted MAR and NGF sequences were consistent with those inserted into the plasmid before recombination. Therefore, we concluded that the MAR characteristic element mediates vector adhesion to CHO cells and enhances the stability and efficiency of the target gene expression. PMID:26345852

  13. Expression of IMP1 enhances production of murine leukemia virus vector by facilitating viral genomic RNA packaging.

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    Yun Mai

    Full Text Available Murine leukemia virus (MLV-based retroviral vector is widely used for gene transfer. Efficient packaging of the genomic RNA is critical for production of high-titer virus. Here, we report that expression of the insulin-like growth factor II mRNA binding protein 1 (IMP1 enhanced the production of infectious MLV vector. Overexpression of IMP1 increased the stability of viral genomic RNA in virus producer cells and packaging of the RNA into progeny virus in a dose-dependent manner. Downregulation of IMP1 in virus producer cells resulted in reduced production of the retroviral vector. These results indicate that IMP1 plays a role in regulating the packaging of MLV genomic RNA and can be used for improving production of retroviral vectors.

  14. Adenoviral vector expressing murine β-defensin 2 enhances immunogenicity of an adenoviral vector based H5N1 influenza vaccine in aged mice.

    Science.gov (United States)

    Vemula, Sai V; Pandey, Aseem; Singh, Neetu; Katz, Jacqueline M; Donis, Ruben; Sambhara, Suryaprakash; Mittal, Suresh K

    2013-10-01

    The ability to resist infections and respond to vaccinations is greatly reduced in the older adult population owing to a general decline in innate and adaptive immune functions with aging. Over the years several strategies such as increasing the vaccine dose, number of immunizations and using adjuvants have been evaluated to improve the immunogenicity and efficacy of vaccines in the older adult population. Murine β-defensin 2 (Mbd2) has been shown to function as a molecular adjuvant by recruiting and activating immature dendritic cells (DCs), professional antigen-presenting cells (APC), to the site of the immunization. In this study, we evaluated the potential utility of Mbd2 to enhance the efficacy of an adenoviral vector-based H5N1 influenza vaccine expressing hemagglutinin (HA) and nucleoprotein (NP) (HAd-HA-NP) in an aged mouse model. Our results indicated that immunostimulation with an adenoviral vector expressing Mbd2 (HAd-Mbd2) activated DCs and significantly enhanced the humoral and cellular immune responses induced by HAd-HA-NP. Furthermore, immunostimulation with HAd-Mbd2 followed by immunization with HAd-HA-NP resulted in significantly lower virus titers in the lungs following challenge with a H5N1 influenza virus compared to the group immunized with HAd-HA-NP without immunostimulation. Overall, our results highlight the potential utility of Mbd2 as a molecular adjuvant to enhance the immunogenicity and protective efficacy of vaccines for the elderly. PMID:23892144

  15. Potential of cancer screening with serum surface-enhanced Raman spectroscopy and a support vector machine

    International Nuclear Information System (INIS)

    Cancer is the most common disease to threaten human health. The ability to screen individuals with malignant tumours with only a blood sample would be greatly advantageous to early diagnosis and intervention. This study explores the possibility of discriminating between cancer patients and normal subjects with serum surface-enhanced Raman spectroscopy (SERS) and a support vector machine (SVM) through a peripheral blood sample. A total of 130 blood samples were obtained from patients with liver cancer, colonic cancer, esophageal cancer, nasopharyngeal cancer, gastric cancer, as well as 113 blood samples from normal volunteers. Several diagnostic models were built with the serum SERS spectra using SVM and principal component analysis (PCA) techniques. The results show that a diagnostic accuracy of 85.5% is acquired with a PCA algorithm, while a diagnostic accuracy of 95.8% is obtained using radial basis function (RBF), PCA–SVM methods. The results prove that a RBF kernel PCA–SVM technique is superior to PCA and conventional SVM (C-SVM) algorithms in classification serum SERS spectra. The study demonstrates that serum SERS, in combination with SVM techniques, has great potential for screening cancerous patients with any solid malignant tumour through a peripheral blood sample. (letters)

  16. An Enhanced MEMS Error Modeling Approach Based on Nu-Support Vector Regression

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    Deepak Bhatt

    2012-07-01

    Full Text Available Micro Electro Mechanical System (MEMS-based inertial sensors have made possible the development of a civilian land vehicle navigation system by offering a low-cost solution. However, the accurate modeling of the MEMS sensor errors is one of the most challenging tasks in the design of low-cost navigation systems. These sensors exhibit significant errors like biases, drift, noises; which are negligible for higher grade units. Different conventional techniques utilizing the Gauss Markov model and neural network method have been previously utilized to model the errors. However, Gauss Markov model works unsatisfactorily in the case of MEMS units due to the presence of high inherent sensor errors. On the other hand, modeling the random drift utilizing Neural Network (NN is time consuming, thereby affecting its real-time implementation. We overcome these existing drawbacks by developing an enhanced Support Vector Machine (SVM based error model. Unlike NN, SVMs do not suffer from local minimisation or over-fitting problems and delivers a reliable global solution. Experimental results proved that the proposed SVM approach reduced the noise standard deviation by 10–35% for gyroscopes and 61–76% for accelerometers. Further, positional error drifts under static conditions improved by 41% and 80% in comparison to NN and GM approaches.

  17. Intranasal vaccination with a helper-dependent adenoviral vector enhances transgene-specific immune responses in BALB/c mice.

    Science.gov (United States)

    Fu, Yuan-hui; He, Jin-sheng; Zheng, Xian-xian; Wang, Xiao-bo; Xie, Can; Shi, Chang-xin; Zhang, Mei; Tang, Qian; Wei, Wei; Qu, Jian-guo; Hong, Tao

    2010-01-01

    Helper-dependent adenoviral (HDAd) vectors were developed primarily for genetic disease therapy by deleting all coding regions for attenuating the host cellular immune response to adenovirus (Ad) and long-lasting gene expression. Recently Harui et al. reported that HDAd vaccine could stimulate superior transgene-specific cytotoxic T lymphocyte (CTL) and antibody responses via the intraperitoneal route, compared to first-generation adenoviral (FGAd) vaccine. This prompted us to explore the potential of HDAd as a vaccine vector administrated intranasally. In this study, we prepared HDAd and FGAd vectors expressing enhanced green fluorescent protein (EGFP), respectively, and compared their efficacy in mice. Mice were immunized intranasally with 5x10(9) vp HDAd or FGAd vector particles. Despite stimulating similar anti-Ad antibody responses with FGAd vaccine in the prime/boost strategy, HDAd vector expressing EGFP displayed superior transgene-specific serum IgG, mucosal IgA and cellular immune response, with the characterization of balanced or mixed Th1/Th2 CD4+ T-cell responses. Meanwhile, a single dose of intranasal (i.n.) vaccine of HDAd-EGFP induced a serum IgG response with more efficacy than FGAd-EGFP. In addition, i.n. boost immunization enhanced transgene-specific humoral and cellular responses, compared to single i.n. HDAd-EGFP immunization. Our results suggest that HDAd has potential for a mucosal vaccine vector via i.n. route, which will be useful for the development of vaccines against respiratory viruses, such as respiratory syncytial virus and influenza virus. PMID:19945423

  18. An Investigation on Satisfaction of Domestic Tourist from Ankara Shopping Fest under the Tourism of Festival

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    Ahmet TAYFUN

    2013-06-01

    Full Text Available Concentration of Tourism mostly in coastal of Turkey, in certain centers and in summer season stands out as a major problem. A tourism mobility that, spread over 12 months, and including inner zones is emphasized also in 2023 Tourism Strategy of Turkey. Therefore, increasing the diversity of tourism such as festivals, which started to increase number of events. Hence, investigated in this study, satisfaction levels from Ankara Shopping Fest of domestic tourists, who came to Ankara during "Ankara Shopping Fest" which, organized in Ankara on 8 June to 1 July 2012 period. Descriptive research method used in the study. The aims in this study, determination of the views of local tourists about Ankara Shopping Fest and to investigate the satisfaction from the festival. 336 domestic tourists as visitors during the festival in Ankara were the sample of research. Questionnaire technique was used as a data collection technique. The questionnaire consisted of three parts, the first section was demographic variables. The second section was located expressions for Ankara Shopping Fest. Some statical analysis made to data in the result of research. These analyses were frequecy analysis, t tests and ANOVA tests. As a result of the t-tests and ANOVA tests significant differences were found between gender, age, level of income and civil staus of domestic tourists who came to Ankara during the festival.

  19. Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia

    LENUS (Irish Health Repository)

    McGinley, Lisa

    2011-03-07

    Abstract Introduction A combination of gene and cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal stem cells (MSCs). The development of efficient gene delivery methods is essential if MSCs are to be of benefit using such an approach. Achieving high levels of transgene expression for the required period of time, without adversely affecting cell viability and differentiation capacity, is crucial. In the present study, we investigate lentiviral vector-mediated genetic modification of rat bone-marrow derived MSCs and examine any functional effect of such genetic modification in an in vitro model of ischaemia. Methods Transduction efficiency and transgene persistence of second and third generation rHIV-1 based lentiviral vectors were tested using reporter gene constructs. Use of the rHIV-pWPT-EF1-α-GFP-W vector was optimised in terms of dose, toxicity, cell species, and storage. The in vivo condition of ischaemia was modelled in vitro by separation into its associated constituent parts i.e. hypoxia, serum and glucose deprivation, in which the effect of therapeutic gene over-expression on MSC survival was investigated. Results The second generation lentiviral vector rHIV-pWPT-EF1-α-GFP-W, was the most efficient and provided the most durable transgene expression of the vectors tested. Transduction with this vector did not adversely affect MSC morphology, viability or differentiation potential, and transgene expression levels were unaffected by cryopreservation of transduced cells. Over-expression of HSP70 resulted in enhanced MSC survival and increased resistance to apoptosis in conditions of hypoxia and ischaemia. MSC differentiation capacity was significantly reduced after oxygen deprivation, but was preserved with HSP70 over-expression. Conclusions Collectively, these data validate the use of lentiviral vectors for efficient in vitro gene delivery to MSCs and suggest that lentiviral vector transduction can facilitate

  20. Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia.

    LENUS (Irish Health Repository)

    McGinley, Lisa

    2012-01-31

    INTRODUCTION: A combination of gene and cell therapies has the potential to significantly enhance the therapeutic value of mesenchymal stem cells (MSCs). The development of efficient gene delivery methods is essential if MSCs are to be of benefit using such an approach. Achieving high levels of transgene expression for the required period of time, without adversely affecting cell viability and differentiation capacity, is crucial. In the present study, we investigate lentiviral vector-mediated genetic modification of rat bone-marrow derived MSCs and examine any functional effect of such genetic modification in an in vitro model of ischaemia. METHODS: Transduction efficiency and transgene persistence of second and third generation rHIV-1 based lentiviral vectors were tested using reporter gene constructs. Use of the rHIV-pWPT-EF1-alpha-GFP-W vector was optimised in terms of dose, toxicity, cell species, and storage. The in vivo condition of ischaemia was modelled in vitro by separation into its associated constituent parts i.e. hypoxia, serum and glucose deprivation, in which the effect of therapeutic gene over-expression on MSC survival was investigated. RESULTS: The second generation lentiviral vector rHIV-pWPT-EF1-alpha-GFP-W, was the most efficient and provided the most durable transgene expression of the vectors tested. Transduction with this vector did not adversely affect MSC morphology, viability or differentiation potential, and transgene expression levels were unaffected by cryopreservation of transduced cells. Over-expression of HSP70 resulted in enhanced MSC survival and increased resistance to apoptosis in conditions of hypoxia and ischaemia. MSC differentiation capacity was significantly reduced after oxygen deprivation, but was preserved with HSP70 over-expression. CONCLUSIONS: Collectively, these data validate the use of lentiviral vectors for efficient in vitro gene delivery to MSCs and suggest that lentiviral vector transduction can facilitate

  1. Deletion of the LTR Enhancer/Promoter Has No Impact on the Integration Profile of MLV Vectors in Human Hematopoietic Progenitors

    OpenAIRE

    Moiani, Arianna; Miccio, Annarita; Rizzi, Ermanno; Severgnini, Marco; Pellin, Danilo; Suerth, Julia Debora; Baum, Christopher; De Bellis, Gianluca; MAVILIO, Fulvio

    2013-01-01

    Moloney murine leukemia virus (MLV)-derived gamma-retroviral vectors integrate preferentially near transcriptional regulatory regions in the human genome, and are associated with a significant risk of insertional gene deregulation. Self-inactivating (SIN) vectors carry a deletion of the U3 enhancer and promoter in the long terminal repeat (LTR), and show reduced genotoxicity in pre-clinical assays. We report a high-definition analysis of the integration preferences of a SIN MLV vector compare...

  2. Behzat Ç. An Ankara Detective: An Audience Perception Analysis

    Directory of Open Access Journals (Sweden)

    Tülay Şeker

    2011-09-01

    Full Text Available This study was proposed to reveal how “Behzat Ç. An Ankara Detective” serial is perceived among audiences. The research was done by 11 participants and by means of deep engagements audience notions devoted to reception aesthetic were examined. It was confirmed that audiences were highly sensitive to messages. We acquired that socio-demographic variables differ from presented content in terms of resistance. While sense production related to social reality was closer to mass media reality among the youth, elder groups and educateds producted senses that did not coincide with tendency of serial. During the engagements, Behzat Ç. was characterized as a political person and the idea that certain political parties and communities were targeted became prominent. It was determined that the audience of Behzat Ç. interprets each message according to his or her intellectual and ideological framework with an active and sensitive eye.

  3. Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity

    OpenAIRE

    Bartel, Melissa; Schaffer, David; Büning, Hildegard

    2011-01-01

    Vectors based on adeno-associated viruses (AAV) have shown considerable promise in both preclinical models and increasingly in clinical trials. However, one formidable challenge is pre-existing immunity due to widespread exposure to numerous AAV variants and serotypes within the human population, which affect efficacy of clinical trials due to the accompanying high levels of anti-capsid neutralizing antibodies. Transient immunosuppression has promise in mitigating cellular and humoral respons...

  4. Enhancing the clinical potential of AAV vectors by capsid engineering to evade pre-existing immunity

    OpenAIRE

    DavidSchaffer; HildegardBüning

    2011-01-01

    Vectors based on adeno-associated viruses have shown considerable promise in both preclinical models and increasingly in clinical trials. However, one formidable challenge is pre-existing immunity due to widespread exposure to numerous AAV variants and serotypes within the human population, which affect efficacy of clinical trials due to the accompanying high levels of anti-capsid neutralizing antibodies. Transient immunosuppression has promise in mitigating cellular and humoral responses ind...

  5. Support Vector Classifier with enhanced feature selection for transient stability evaluation

    OpenAIRE

    Balasingh Selvi Arul Dora; Nagappan Kamaraj

    2009-01-01

    Today's power transmission systems have a tendency to operate closer and closer to their stability limits. In this scenario, there have been continuous efforts to develop new techniques and tools for assessing the stability status of power systems. This paper presents a Support Vector Classifier (SVC) to identify the transient stability of power systems subjected to severe disturbances. The nonlinear relationship between the pre-fault, during-fault and post-fault power system parameters and t...

  6. Ankara Historic City Centre Restoration Site Conservation Plan, its Characteristics, and Rationales for its Revocation

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    Mehmet Tuncer

    2013-12-01

    Full Text Available This is a comprehensive evaluation of the 1: 5000 Ankara Historic City Centre Restoration Site Conservation Master Development Plan and the 1: 1000 Conservation Implementation Plans, which have become a matter of litigation against the Ankara Metropolitan Municipality, filed by various non-governmental organizations, universities, the Union of Chambers of Turkish Architects and Engineers (TMMOB and public institutions; in terms of the environment, transportation and traffic as regards the entirety of the planned location, and the integrity of the plan, based on conservation-reclamation planning essentials and public interest. Thus the Ulus Ankara Historic City Centre Restoration Site Conservation Master Development and Implementation Plan and Plan Notes as ratified by the Ankara Metropolitan Municipality and Conservation Board, are examined in this context in terms of restoration site, protected site, conservation site, interaction and transition sites and historic and cultural properties.

  7. The role of enhanced radiosensitivity and tumor-specific suicide gene vector in genetherapy of nasopharyngeal carcinoma

    International Nuclear Information System (INIS)

    Nasopharyngeal carcinoma (NPC) is one of the common malignant tumors in China. Radiotherapy and chemotherapy are the main therapy methods for NPC. To enhance the specific antitumor effect, a novel vector with radiosensitivity and tumor specificity was constructed in this study, which enables the reduction of dosage of radiation and chemotherapeutic drugs due to its double killing effect. Four DNA elements, Egr-1 promoter, Cytosine deaminase (CD) gene, human telomerase reverse transcriptase (hTERT) promoter, Survivin antisense oligonucleotides were amplified and constructed in pcDNA3.1 vector. CD and Survivin gene expression in CNE-2 cells were detected by reverse transcription-polymerase chain reaction (RT-PCR). High performance liquid chromatography (HPLC) was employed to determine the transformation from the prodrugs 5-fluorocytosine (FC) to 5- fluorouracil (FU). Hoechst33258 staining of the nuclei and methylthiazolyl tetrazolium (MTT) assay were applied to detect apoptosis and cell survivability, respectively. In addition, the anti-tumor effects were examined in vivo by injecting cells with different vectors into nude mice. Our results revealed a notable killing effect of combined treatment with 5-FC and radiation on CNE-2 cells transfected with vectors in vitro. This effect was especially notable on pEC-TS transferred cells, which showed 57% of cells were killed. In vivo, an obvious suppression of tumor was displayed in pEC-TS group, which was significantly different from other groups (p<0.05). Consequently, this expression cassette may have a great therapeutic potential for the treatment of NPC. (author)

  8. Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells

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    Wang Pin

    2011-01-01

    Full Text Available Abstract Background Dendritic cells (DCs are antigen-presenting immune cells that interact with T cells and have been widely studied for vaccine applications. To achieve this, DCs can be manipulated by lentiviral vectors (LVs to express antigens to stimulate the desired antigen-specific T cell response, which gives this approach great potential to fight diseases such as cancers, HIV, and autoimmune diseases. Previously we showed that LVs enveloped with an engineered Sindbis virus glycoprotein (SVGmu could target DCs through a specific interaction with DC-SIGN, a surface molecule predominantly expressed by DCs. We hypothesized that SVGmu interacts with DC-SIGN in a mannose-dependent manner, and that an increase in high-mannose structures on the glycoprotein surface could result in higher targeting efficiencies of LVs towards DCs. It is known that 1-deoxymannojirimycin (DMJ can inhibit mannosidase, which is an enzyme that removes high-mannose structures during the glycosylation process. Thus, we investigated the possibility of generating LVs with enhanced capability to modify DCs by supplying DMJ during vector production. Results Through western blot analysis and binding tests, we were able to infer that binding of SVGmu to DC-SIGN is directly related to amount of high-mannose structures on SVGmu. We also found that the titer for the LV (FUGW/SVGmu produced with DMJ against 293T.DCSIGN, a human cell line expressing the human DC-SIGN atnibody, was over four times higher than that of vector produced without DMJ. In addition, transduction of a human DC cell line, MUTZ-3, yielded a higher transduction efficiency for the LV produced with DMJ. Conclusion We conclude that LVs produced under conditions with inhibited mannosidase activity can effectively modify cells displaying the DC-specific marker DC-SIGN. This study offers evidence to support the utilization of DMJ in producing LVs that are enhanced carriers for the development of DC-directed vaccines.

  9. Support vector data description for fusion of multiple health indicators for enhancing gearbox fault diagnosis and prognosis

    International Nuclear Information System (INIS)

    A novel method for enhancing gearbox fault diagnosis and prognosis is developed by fusion of multiple health indicators through support vector data description. First, the Comblet transform is used to identify gear residual error signals from the raw signal. Second, based on the observation of gear residual error signals, a total of 11 gear health indicators are identified, and are categorized into two types of indicators. The first and second types of indicators are for fault diagnosis and prognosis, respectively. The first type has six indicators, which are sensitive to impulsive signals triggered by anomalous impacts. The second type has five indicators, which are suitable for tracking degradation of faults. Third, through the support vector data description, the first six health indicators are fused into type one indicators for fault diagnosis. The remaining five indicators are fused into type two indicators for fault prognosis. Finally, a Gaussian kernel is designed to enhance the performance of type one and two indicators by optimal range of width size. The effectiveness of the proposed method is validated through experiments. The new method has been proven to be superior to methods that use unfused indicators individually

  10. An enhanced method for sequence walking and paralog mining: TOPO® Vector-Ligation PCR

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    Davis Thomas M

    2010-03-01

    Full Text Available Abstract Background Although technological advances allow for the economical acquisition of whole genome sequences, many organisms' genomes remain unsequenced, and fully sequenced genomes may contain gaps. Researchers reliant upon partial genomic or heterologous sequence information require methods for obtaining unknown sequences from loci of interest. Various PCR based techniques are available for sequence walking - i.e., the acquisition of unknown DNA sequence adjacent to known sequence. Many such methods require rigid, elaborate protocols and/or impose narrowly confined options in the choice of restriction enzymes for necessary genomic digests. We describe a new method, TOPO® Vector-Ligation PCR (or TVL-PCR that innovatively integrates available tools and familiar concepts to offer advantages as a means of both targeted sequence walking and paralog mining. Findings TVL-PCR exploits the ligation efficiency of the pCR®4-TOPO® (Invitrogen, Carlsbad, California vector system to capture fragments of unknown sequence by creating chimeric molecules containing defined priming sites at both ends. Initially, restriction enzyme-digested genomic DNA is end-repaired to create 3' adenosine overhangs and is then ligated to pCR4-TOPO vectors. The ligation product pool is used directly as a template for nested PCR, using specific primers to target orthologous sequences, or degenerate primers to enable capture of paralogous gene family members. We demonstrated the efficacy of this method by capturing entire coding and partial promoter sequences of several strawberry Superman-like genes. Conclusions TVL-PCR is a convenient and efficient method for DNA sequence walking and paralog mining that is applicable to any organism for which relevant DNA sequence is available as a basis for primer design.

  11. Landscaping to Reduce Traffic Noise Problem in Cities: Ankara Case

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    M. E. Yazgan

    2007-05-01

    Full Text Available Cities are suffering under the effects of unexpected population growth due to immigration to metropolitan areas. Thus, urban environments are heavily loaded so that the existing infrastructure becomes insufficient and new services are needed. Besides the technological developments and changes in the community, urban environments are affected negatively due to transporation and traffic problems. On one hand, highways built to shorten the travel period and the bypasses to speed transportation time and capacity brings comfort in service functions, on the other hand, creates numerous negative effects like functional, visual and auditory damages in urban environments. In this article, noise, sources of noise and other related terminology were identified then, negative effects of noise in urban areas and the precautions that has to be taken were determined. At the final stage, the role of plant material in reducing the effects of noise was discussed and the plantation design for an effective noise control and plant species that could be used to eleminate or reduce noise for Ankara city were proposed.

  12. Archaeometric exploration at Akköprü in Ankara

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    Ali Akın Akyol

    2013-01-01

    Full Text Available The archaeometric exploration was conducted by surveying and sampling studies on the stone, and mortar samples from Akköprü in Ankara. Spot salt test and conductometric analysis were applied to get water soluble salt content of stone samples. The aggregate and binder part of the mortars were determined by the analyses of acidic aggregate & binder, aggregate granulometry, thin section optic microscopy and X-ray diffraction. In addition, the physical conditions of the stones were determined by some physical tests. The results of archaeometrical data showed that the constructive stone material was mainly andesite besides ignimbrite and dacite, and the original binder material was lime mortar. The cement content of the binder of mortars reveals the recent interventions on Akköprü. In the light of petrographic studies it was understood that the source of the original constructive raw material reflects the local formation. The high soluble salt content and the bad physical conditions of some stones also showed that they are undergoing a decomposition process of different degrees.

  13. Lottery Houses (İş Bank in Ankara

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    Umut Şumnu

    2014-06-01

    Full Text Available The importance of (savings incentive lottery houses that emerged in the late 1930’s and served for nearly fourty years as tools in the formation and development of Turkey’s accommodation/habitation culture has been largely ignored in architectural history. The mainstream historic accounts based mostly on public buildings or a minimum of civil architectural constructions that may only serve an ideological “benefit” for the dominant narrative, have disregarded the field of lottery houses. Lottery houses have stayed/keptout of the traditional narrative based on the accommodation culture proposed by the state. Thus, this study aims to investigate the lottery houses process in Turkey, and look at the development of that process, as regards particularly the buildings produced by İş Bank in Ankara. İş Bank was chosen as the subject, as it was the originator of the savings incentive lottery house plans and it has emerged as one of the most well-established and powerful institutions in the process, producing architectural constructions distinctive both in terms of quality and quantity.

  14. HEALTH BEHAVIOURS OF THE PERSONNEL OF PRIMARY SCHOOLS IN ANKARA

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    Serife AK

    2006-04-01

    Full Text Available The main purpose of study is to define the health behaviour profile of the personnel of primary schools as well as to define the topics to be given priority in health education activities. The research population consisted of all personnel of 564 primary schools in Ankara province. The study group (30 schools was estimated by cluster sampling method. The Health Behaviours Questionnaire, which consists of 47 items on health behaviours and demographic characteristics, was used for data collection. In the study, 849 school workers (67,5% female were interviewed. Teachers constituted the largest group (82,3% while the cleaning staff (7.0%, school administrators (6.3%, and other personnel (4.4% were sharing the rest in small proportions. Of the study group 41,7 % are cigarette smokers and of them 67.3% smoke every time and 11,9% sometime in school. Very few school personnel (14,8% do physical exercise regularly. Majority of school personnel (71,3% stated that they brush their teeth at least twice a day regularly. However, only 23,7% of school personnel go to have regular dental control. All results were discussed in details considering the effects of health behaviours of school personnel on students, and some recommendations were developed for health education activities in schools. [TAF Prev Med Bull 2006; 5(2.000: 83-93

  15. Characterization and source determination of air pollution in Ankara

    International Nuclear Information System (INIS)

    The sources of air pollution in Ankara and the effect of these sources on rainwater composition were studied by collecting rainwater and aerosol samples over a one year period in 1988. The rain water was not acidic owing to high concentrations of alkaline soil particles in the atmosphere. However, the concentrations of acid forming ions, such as SO42- and NO3-, were higher than concentrations expected in a typical urban atmosphere. Most of the SO42- in rain water was in the form of CaSO4. The ions most efficiently scavenged from the atmosphere were found to be SO42- and Ca2+. Atomspheric concentrations of approximately thirty elements indicated that road dust, motor vehicles, coal and oil combustion are the main components of aerosols over the city. Elements which have origins in industrial processes were not enriched substantially and do not show seasonal dependence, whereas elements which originate from coal combustion for residential heating are highly enriched and have higher concentrations in the winter. Road dust was enriched in Pb and Br and does not show characteristic soil composition. (author). 8 refs, 5 figs, 7 tabs

  16. Relevance Vector Machines for Enhanced BER Probability in DMT-Based Systems

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    Ashraf A. Tahat

    2010-01-01

    Full Text Available A new channel estimation method for discrete multitone (DMT communication system based on sparse Bayesian learning relevance vector machine (RVM method is presented. The Bayesian frame work is used to obtain sparse solutions for regression tasks with linear models. By exploiting a probabilistic Bayesian learning framework, sparse Bayesian learning provides accurate models for estimation and consequently equalization. We consider frequency domain equalization (FEQ using the proposed channel estimate at both the transmitter (preequalization and receiver (postequalization and compare the resulting bit error rate (BER performance curves for both approaches and various channel estimation techniques. Simulation results show that the proposed RVM-based method is superior to the traditional least squares technique.

  17. Support Vector Classifier with enhanced feature selection for transient stability evaluation

    Directory of Open Access Journals (Sweden)

    Balasingh Selvi Arul Dora

    2009-01-01

    Full Text Available Today's power transmission systems have a tendency to operate closer and closer to their stability limits. In this scenario, there have been continuous efforts to develop new techniques and tools for assessing the stability status of power systems. This paper presents a Support Vector Classifier (SVC to identify the transient stability of power systems subjected to severe disturbances. The nonlinear relationship between the pre-fault, during-fault and post-fault power system parameters and the stability status of the system under post-fault state is captured by the SVC trained offline. Significant generators are selected by feature selection based on the sensitivity of stability margin and the features other than generators are selected based on a step wise feature selection by three fold cross validation. The performance of the proposed SVC is demonstrated through the simulations carried out on the IEEE 17 generator reduced Iowa system.

  18. Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence.

    Directory of Open Access Journals (Sweden)

    Konstantin A Tsetsarkin

    2011-12-01

    Full Text Available The adaptation of Chikungunya virus (CHIKV to a new vector, the Aedes albopictus mosquito, is a major factor contributing to its ongoing re-emergence in a series of large-scale epidemics of arthritic disease in many parts of the world since 2004. Although the initial step of CHIKV adaptation to A. albopictus was determined to involve an A226V amino acid substitution in the E1 envelope glycoprotein that first arose in 2005, little attention has been paid to subsequent CHIKV evolution after this adaptive mutation was convergently selected in several geographic locations. To determine whether selection of second-step adaptive mutations in CHIKV or other arthropod-borne viruses occurs in nature, we tested the effect of an additional envelope glycoprotein amino acid change identified in Kerala, India in 2009. This substitution, E2-L210Q, caused a significant increase in the ability of CHIKV to develop a disseminated infection in A. albopictus, but had no effect on CHIKV fitness in the alternative mosquito vector, A. aegypti, or in vertebrate cell lines. Using infectious viruses or virus-like replicon particles expressing the E2-210Q and E2-210L residues, we determined that E2-L210Q acts primarily at the level of infection of A. albopictus midgut epithelial cells. In addition, we observed that the initial adaptive substitution, E1-A226V, had a significantly stronger effect on CHIKV fitness in A. albopictus than E2-L210Q, thus explaining the observed time differences required for selective sweeps of these mutations in nature. These results indicate that the continuous CHIKV circulation in an A. albopictus-human cycle since 2005 has resulted in the selection of an additional, second-step mutation that may facilitate even more efficient virus circulation and persistence in endemic areas, further increasing the risk of more severe and expanded CHIK epidemics.

  19. Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence.

    Science.gov (United States)

    Tsetsarkin, Konstantin A; Weaver, Scott C

    2011-12-01

    The adaptation of Chikungunya virus (CHIKV) to a new vector, the Aedes albopictus mosquito, is a major factor contributing to its ongoing re-emergence in a series of large-scale epidemics of arthritic disease in many parts of the world since 2004. Although the initial step of CHIKV adaptation to A. albopictus was determined to involve an A226V amino acid substitution in the E1 envelope glycoprotein that first arose in 2005, little attention has been paid to subsequent CHIKV evolution after this adaptive mutation was convergently selected in several geographic locations. To determine whether selection of second-step adaptive mutations in CHIKV or other arthropod-borne viruses occurs in nature, we tested the effect of an additional envelope glycoprotein amino acid change identified in Kerala, India in 2009. This substitution, E2-L210Q, caused a significant increase in the ability of CHIKV to develop a disseminated infection in A. albopictus, but had no effect on CHIKV fitness in the alternative mosquito vector, A. aegypti, or in vertebrate cell lines. Using infectious viruses or virus-like replicon particles expressing the E2-210Q and E2-210L residues, we determined that E2-L210Q acts primarily at the level of infection of A. albopictus midgut epithelial cells. In addition, we observed that the initial adaptive substitution, E1-A226V, had a significantly stronger effect on CHIKV fitness in A. albopictus than E2-L210Q, thus explaining the observed time differences required for selective sweeps of these mutations in nature. These results indicate that the continuous CHIKV circulation in an A. albopictus-human cycle since 2005 has resulted in the selection of an additional, second-step mutation that may facilitate even more efficient virus circulation and persistence in endemic areas, further increasing the risk of more severe and expanded CHIK epidemics. PMID:22174678

  20. A Non-static Data Layout Enhancing Parallelism and Vectorization in Sparse Grid Algorithms

    KAUST Repository

    Buse, Gerrit

    2012-06-01

    The name sparse grids denotes a highly space-efficient, grid-based numerical technique to approximate high-dimensional functions. Although employed in a broad spectrum of applications from different fields, there have only been few tries to use it in real time visualization (e.g. [1]), due to complex data structures and long algorithm runtime. In this work we present a novel approach inspired by principles of I/0-efficient algorithms. Locally applied coefficient permutations lead to improved cache performance and facilitate the use of vector registers for our sparse grid benchmark problem hierarchization. Based on the compact data structure proposed for regular sparse grids in [2], we developed a new algorithm that outperforms existing implementations on modern multi-core systems by a factor of 37 for a grid size of 127 million points. For larger problems the speedup is even increasing, and with execution times below 1 s, sparse grids are well-suited for visualization applications. Furthermore, we point out how a broad class of sparse grid algorithms can benefit from our approach. © 2012 IEEE.

  1. Immunogenicity and protective efficacy of recombinant Modified Vaccinia virus Ankara candidate vaccines delivering West Nile virus envelope antigens.

    Science.gov (United States)

    Volz, Asisa; Lim, Stephanie; Kaserer, Martina; Lülf, Anna; Marr, Lisa; Jany, Sylvia; Deeg, Cornelia A; Pijlman, Gorben P; Koraka, Penelope; Osterhaus, Albert D M E; Martina, Byron E; Sutter, Gerd

    2016-04-01

    West Nile virus (WNV) cycles between insects and wild birds, and is transmitted via mosquito vectors to horses and humans, potentially causing severe neuroinvasive disease. Modified Vaccinia virus Ankara (MVA) is an advanced viral vector for developing new recombinant vaccines against infectious diseases and cancer. Here, we generated and evaluated recombinant MVA candidate vaccines that deliver WNV envelope (E) antigens and fulfil all the requirements to proceed to clinical testing in humans. Infections of human and equine cell cultures with recombinant MVA demonstrated efficient synthesis and secretion of WNV envelope proteins in mammalian cells non-permissive for MVA replication. Prime-boost immunizations in BALB/c mice readily induced circulating serum antibodies binding to recombinant WNV E protein and neutralizing WNV in tissue culture infections. Vaccinations in HLA-A2.1-/HLA-DR1-transgenic H-2 class I-/class II-knockout mice elicited WNV E-specific CD8+ T cell responses. Moreover, the MVA-WNV candidate vaccines protected C57BL/6 mice against lineage 1 and lineage 2 WNV infection and induced heterologous neutralizing antibodies. Thus, further studies are warranted to evaluate these recombinant MVA-WNV vaccines in other preclinical models and use them as candidate vaccine in humans. PMID:26939903

  2. Disruption of Microtubules Post-Virus Entry Enhances Adeno-Associated Virus Vector Transduction.

    Science.gov (United States)

    Xiao, Ping-Jie; Mitchell, Angela M; Huang, Lu; Li, Chengwen; Samulski, R Jude

    2016-04-01

    Perinuclear retention of viral particles is a poorly understood phenomenon observed during many virus infections. In this study, we investigated whether perinuclear accumulation acts as a barrier to limit recombinant adeno-associated virus (rAAV) transduction. After nocodazole treatment to disrupt microtubules at microtubule-organization center (MT-MTOC) after virus entry, we observed higher rAAV transduction. To elucidate the role of MT-MTOC in rAAV infection and study its underlying mechanisms, we demonstrated that rAAV's perinuclear localization was retained by MT-MTOC with fluorescent analysis, and enhanced rAAV transduction from MT-MTOC disruption was dependent on the rAAV capsid's nuclear import signals. Interestingly, after knocking down RhoA or inhibiting its downstream effectors (ROCK and Actin), MT-MTOC disruption failed to increase rAAV transduction or nuclear entry. These data suggest that enhancement of rAAV transduction is the result of increased trafficking to the nucleus via the RhoA-ROCK-Actin pathway. Ten-fold higher rAAV transduction was also observed by disrupting MT-MTOC in brain, liver, and tumor in vivo. In summary, this study indicates that virus perinuclear accumulation at MT-MTOC is a barrier-limiting parameter for effective rAAV transduction and defines a novel defense mechanism by which host cells restrain viral invasion. PMID:26942476

  3. Adenovirus vectored vaccines against influenza a virus do not result in vaccine associated enhanced respiratory disease following heterologous challenge in contrast to whole inactivated virus vaccine

    Science.gov (United States)

    Heterologous influenza A virus (IAV) challenge following vaccination with an intramuscular (IM) whole inactivated vaccine (WIV) can result in vaccine-associated enhanced respiratory disease (VAERD). The objective of this study was to use an adenovirus (Ad5) vector vaccine platform that expressed IAV...

  4. Role of liposome and peptide in the synergistic enhancement of transfection with a lipopolyplex vector

    Science.gov (United States)

    Munye, Mustafa M.; Ravi, Jascindra; Tagalakis, Aristides D.; McCarthy, David; Ryadnov, Maxim G.; Hart, Stephen L.

    2015-03-01

    Lipopolyplexes are of widespread interest for gene therapy due to their multifunctionality and high transfection efficiencies. Here we compared the biological and biophysical properties of a lipopolyplex formulation with its lipoplex and polyplex equivalents to assess the role of the lipid and peptide components in the formation and function of the lipopolyplex formulation. We show that peptide efficiently packaged plasmid DNA forming spherical, highly cationic nanocomplexes that are taken up efficiently by cells. However, transgene expression was poor, most likely due to endosomal degradation since the polyplex lacks membrane trafficking properties. In addition the strong peptide-DNA interaction may prevent plasmid release from the complex and so limit plasmid DNA availability. Lipid/DNA lipoplexes, on the other hand, produced aggregated masses that showed poorer cellular uptake than the polyplex but contrastingly greater levels of transgene expression. This may be due to the greater ability of lipoplexes relative to polyplexes to promote endosomal escape. Lipopolyplex formulations formed spherical, cationic nanocomplexes with efficient cellular uptake and significantly enhanced transfection efficiency. The lipopolyplexes combined the optimal features of lipoplexes and polyplexes showing optimal cell uptake, endosomal escape and availability of plasmid for transcription, thus explaining the synergistic increase in transfection efficiency.

  5. Daily Ambrosia Pollen Concentration in the Air of Ankara,Turkey (1990-1999)

    Institute of Scientific and Technical Information of China (English)

    Ayse KAPLAN; Nazmiye SAKIYAN; N Münevver PINAR

    2003-01-01

    The airborne ragweed pollen spectrum was investigated in the air of Ankara, Turkey for aperiod of ten years (1990-1999) using a Burkard seven-day volumetric recording trap. In our study period,long distance transported Ambrosia pollen has been registered. Daily pollen levels varied from low to highin Burge's system. In last three years, the pollen concentration of Ambrosia showed a clear increasingtendency. Our results prove that ragweed pollen may be an important threat for ragweed sensitive patientsin Ankara city in near future.

  6. Root and crown rot and wilt of tomatoes caused by fungal diseases in Ankara province.

    OpenAIRE

    Ozan, S.; Maden, S.

    2009-01-01

    This study was conducted in Ayaş, Beypazarı and Nallıhan districts of Ankara province during May-November 2003-2004 in order to detect fungal pathogens of tomato, and to find out the incidence, prevalence and occurrence times of these pathogens. It is detected that wilt and root rot pathogens causes important yield losses in tomato fields in Ankara. The incidences of the fungi isolated roots and crowns were 17.2 %, 0.96 %, 0.32 %, 0.91 %, 2.95 %,% 0.52 for Pyrenochaeta lycopersici, Fusa...

  7. Enhanced antitumor response mediated by the codelivery of paclitaxel and adenoviral vector expressing IL-12.

    Science.gov (United States)

    Cao, Linjie; Zeng, Qin; Xu, Chaoqun; Shi, Sanjun; Zhang, Zhirong; Sun, Xun

    2013-05-01

    It has been well-established that chemo-immunotherapy using cytotoxic drugs and appropriate cytokines offers a promising approach for the treatment of neoplastic diseases. In view of this, to improve melanoma treatment effect, our study developed a new codelivery system (AL/Ad5/PTX) that paclitaxel (PTX) and adenovirus encoding for murine interleukin-12 (Ad5-mIL-12) were incorporated into anionic liposomes (AL). First, AL/Ad5/PTX complexes were prepared by incorporating Ad5 into anionic PTX liposomes using calcium-induced phase change. Second, the size distribution and zeta potential of AL/Ad5/PTX were investigated. Third, the results of in vitro transduction assays showed that PTX introduced into AL/Ad-luc or AL/Ad5-mIL-12 highly enhanced gene transduction efficiency in B16 cells than naked Ad5 or AL/Ad complexes while it had no comparability in A549 cells. Finally, a melanoma-bearing mouse model was established to assess the antitumor effect. Tumor growth inhibition and prolonged survival time, accompanied by increased mIL-12 or interferon-γ (IFN-γ) expression levels in serum or tumor sites, were observed in mice treated with AL/Ad5-mIL-12/PTX, as compared with those treated with either AL/Ad5-mIL-12 or AL/PTX. In conclusion, these results suggested that codelivery of Ad5-mIL-12 and PTX incorporated into AL could be a relatively efficient strategy for the treatment of melanoma. PMID:23534449

  8. Perfluorochemical (PFC liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 (AdvIL-10 expression in rodent lung

    Directory of Open Access Journals (Sweden)

    Zimmerman Jerry J

    2007-05-01

    Full Text Available Abstract Adenovirus and cationic liposome mediated transfer of Interleukin-10 (IL-10, a potent anti-inflammatory cytokine, has been shown to decrease pro-inflammatory cytokine levels and overall lung inflammation in models of lung transplantation and injury. Limitations to current approaches of IL-10 gene therapy include poor vector delivery methods and pro-inflammatory properties of human IL-10 under certain conditions. We hypothesize that using perfluorochemical (PFC liquid to deliver the highly homologous viral IL-10 (vIL-10, which is predominantly anti-inflammatory with minimal pro-inflammatory activities, can potentially be a more effective strategy to combat inflammatory lung diseases. In this study, we compare the use of PFC liquid versus aerosolized method to deliver adenovirus encoding the vIL-10 gene (AdvIL-10 in C57Bl6 mice. Detectable vIL-10 levels were measured from bronchoalveolar lavage fluid and lung homogenates at one, four, ten and thirty days after AdvIL-10. Furthermore, we determined if use of PFC liquid could allow for the use of a lower dose of AdvIL-10 by comparing the levels of detectable vIL-10 at different doses of AdvIL-10 delivered +/- PFC liquid. Results showed that PFC liquid enhanced detectable vIL-10 by up to ten fold and that PFC liquid allowed the use of ten-fold less vector. PFC liquid increased detectable vIL-10 in lung homogenates at all time points; however, the increase in detectable vIL-10 in BAL fluid peaked at four days and was no longer evident by thirty days after intratracheal instillation. In summary, this is the first report utilizing PFC liquid to enhance the delivery of a potentially therapeutic molecule, vIL-10. We believe this strategy can be used to perform future studies on the use of the predominantly anti-inflammatory vIL-10 to treat inflammatory lung diseases.

  9. Induction of antibody responses to African horse sickness virus (AHSV in ponies after vaccination with recombinant modified vaccinia Ankara (MVA.

    Directory of Open Access Journals (Sweden)

    Rachael Chiam

    Full Text Available BACKGROUND: African horse sickness virus (AHSV causes a non-contagious, infectious disease in equids, with mortality rates that can exceed 90% in susceptible horse populations. AHSV vaccines play a crucial role in the control of the disease; however, there are concerns over the use of polyvalent live attenuated vaccines particularly in areas where AHSV is not endemic. Therefore, it is important to consider alternative approaches for AHSV vaccine development. We have carried out a pilot study to investigate the ability of recombinant modified vaccinia Ankara (MVA vaccines expressing VP2, VP7 or NS3 genes of AHSV to stimulate immune responses against AHSV antigens in the horse. METHODOLOGY/PRINCIPAL FINDINGS: VP2, VP7 and NS3 genes from AHSV-4/Madrid87 were cloned into the vaccinia transfer vector pSC11 and recombinant MVA viruses generated. Antigen expression or transcription of the AHSV genes from cells infected with the recombinant viruses was confirmed. Pairs of ponies were vaccinated with MVAVP2, MVAVP7 or MVANS3 and both MVA vector and AHSV antigen-specific antibody responses were analysed. Vaccination with MVAVP2 induced a strong AHSV neutralising antibody response (VN titre up to a value of 2. MVAVP7 also induced AHSV antigen-specific responses, detected by western blotting. NS3 specific antibody responses were not detected. CONCLUSIONS: This pilot study demonstrates the immunogenicity of recombinant MVA vectored AHSV vaccines, in particular MVAVP2, and indicates that further work to investigate whether these vaccines would confer protection from lethal AHSV challenge in the horse is justifiable.

  10. A novel naturally occurring tandem promoter in modified vaccinia virus ankara drives very early gene expression and potent immune responses.

    Science.gov (United States)

    Wennier, Sonia T; Brinkmann, Kay; Steinhäußer, Charlotte; Mayländer, Nicole; Mnich, Claudia; Wielert, Ursula; Dirmeier, Ulrike; Hausmann, Jürgen; Chaplin, Paul; Steigerwald, Robin

    2013-01-01

    Modified vaccinia virus Ankara (MVA) has been shown to be suitable for the generation of experimental vaccines against cancer and infectious diseases, eliciting strong humoral and cellular immune responses. In viral vectored vaccines, strong recombinant antigen expression and timing of expression influence the quantity and quality of the immune response. Screening of synthetic and native poxvirus promoters for strong protein expression in vitro and potent immune responses in vivo led to the identification of the MVA13.5L promoter, a unique and novel naturally occurring tandem promoter in MVA composed of two 44 nucleotide long repeated motifs, each containing an early promoter element. The MVA13.5L gene is highly conserved across orthopoxviruses, yet its function is unknown. The unique structure of its promoter is not found for any other gene in the MVA genome and is also conserved in other orthopoxviruses. Comparison of the MVA13.5L promoter activity with synthetic poxviral promoters revealed that the MVA13.5L promoter produced higher levels of protein early during infection in HeLa cells and particularly in MDBK cells, a cell line in which MVA replication stops at an early stage before the expression of late genes. Finally, a recombinant antigen expressed under the control of this novel promoter induced high antibody titers and increased CD8 T cell responses in homologous prime-boost immunization compared to commonly used promoters. In particular, the recombinant antigen specific CD8 T cell responses dominated over the immunodominant B8R vector-specific responses after three vaccinations and even more during the memory phase. These results have identified the native MVA13.5L promoter as a new potent promoter for use in MVA vectored preventive and therapeutic vaccines. PMID:23951355

  11. Hybrid retroviral vector with MCK enhancers inserted in LTR for stable and specific expression of human factor IX in skeletal muscle

    Institute of Scientific and Technical Information of China (English)

    WANG Jian-min 王健民; HOU Jun 侯军; QIU Xin-fang 邱信芳; Kurachi Kotoku; XUE Jing-lun 薛京伦

    2004-01-01

    Background Retroviral vectors have been widely used to introduce foreign into various target cells in vitro, thus showing relatively high systemic delivery efficiency of various transgene products. The authors investigated the stability and efficiency of skeletal muscle-specific hybrid retroviral vectors in expression of human factor IX (FIX) in vitro and iv vivo. Methods FIX cDNA in LIXSN vector was replaced with a FIX minigene containing splicing donor and splicing acceptor sequence of first intron of human FIX gene. Two copies of muscle creatine kinase enhancer (MCK, Me2) were inserted in forward or reverse orientation at NheI site of 3' long terminal repeat (LTR), resulting in two hybrid vectors, which were designated as LMe2IXm2SN(F) and LMe2IXm2SN(R), respectively. The vectors were tested in vitro and in vivo for stability and muscle-specificity of factor IX expression with SCID mice. Results Muscle cells carrying vector with Me2 expressed significantly higher levels of FIX (up to 1800 ng/106.24h) than those without Me2, thus suggesting that Me2 could specifically increase expression level of FIX in muscle cells. Myoblasts transduced with LMe2IXm2SN(R) produced much less FIX in vivo in SCID mice than LMe2IXm2SN(F). One or two copies of Me2 sequence were deleted in myoblasts transduced with LMe2IXm2SN(R) without changing the orientation of Me2. Conclusions LTR inserted with MCK enhancers can specifically increase human FIX expression in skeletal muscle cells in vitro and in vivo, and MCK enhancer should be positioned in the same orientation as that of LTR promoter.

  12. Multifunctional non-viral gene vectors with enhanced stability, improved cellular and nuclear uptake capability, and increased transfection efficiency

    Science.gov (United States)

    Yang, Zhe; Jiang, Zhaozhong; Cao, Zhong; Zhang, Chao; Gao, Di; Luo, Xingen; Zhang, Xiaofang; Luo, Huiyan; Jiang, Qing; Liu, Jie

    2014-08-01

    We have developed a new multifunctional, non-viral gene delivery platform consisting of cationic poly(amine-co-ester) (PPMS) for DNA condensation, PEG shell for nanoparticle stabilization, poly(γ-glutamic acid) (γ-PGA) and mTAT (a cell-penetrating peptide) for accelerated cellular uptake, and a nuclear localization signal peptide (NLS) for enhanced intracellular transport of DNA to the nucleus. In vitro study showed that coating of the binary PPMS/DNA polyplex with γ-PGA promotes cellular uptake of the polyplex particles, particularly by γ-glutamyl transpeptidase (GGT)-positive cells through the GGT-mediated endocytosis pathway. Conjugating PEG to the γ-PGA led to the formation of a ternary PPMS/DNA/PGA-g-PEG polyplex with decreased positive charges on the surface of the polyplex particles and substantially higher stability in serum-containing aqueous medium. The cellular uptake rate was further improved by incorporating mTAT into the ternary polyplex system. Addition of the NLS peptide was designed to facilitate intracellular delivery of the plasmid to the nucleus--a rate-limiting step in the gene transfection process. As a result, compared with the binary PPMS/LucDNA polyplex, the new mTAT-quaternary PPMS/LucDNA/NLS/PGA-g-PEG-mTAT system exhibited reduced cytotoxicity, remarkably faster cellular uptake rate, and enhanced transport of DNA to the nucleus. All these advantageous functionalities contribute to the remarkable gene transfection efficiency of the mTAT-quaternary polyplex both in vitro and in vivo, which exceeds that of the binary polyplex and commercial Lipofectamine™ 2000/DNA lipoplex. The multifunctional mTAT-quaternary polyplex system with improved efficiency and reduced cytotoxicity represents a new type of promising non-viral vectors for the delivery of therapeutic genes to treat tumors.We have developed a new multifunctional, non-viral gene delivery platform consisting of cationic poly(amine-co-ester) (PPMS) for DNA condensation, PEG shell

  13. Internet Use Habits of Students of the Department of Information Management, Hacettepe University, Ankara

    Science.gov (United States)

    Ucak, Nazan Ozenc

    2007-01-01

    The frequency and other characteristics of Internet use of students studying at the Department of Information Management at Hacettep University in Ankara, Turkey, are examined. According to the findings, students prefer electronic media to printed media, they find the easy accessibility of the information more important than the other qualities,…

  14. A New Understanding of Ankara Music within the Context of Global Cultural Flow

    Directory of Open Access Journals (Sweden)

    Ömer Can Satır

    2015-12-01

    Full Text Available The aim of this study is to consider a new understanding of the complex and multilayered structure of Ankara music, which is situated between tradition and modernity and has become an important form of popular culture in the region, in the context of local and global relationships.. The theoretical framework of the study is based on Appadurai’s “global cultural flow” model. The ethnoscape, finanscape, mediascape, technoscape and ideoscape of Ankara music is examined in accordance with this approach to reveal the dynamics that make this music different. In the light of these findings, it is concluded that the ethnoscape of Ankara music is based on a broad demographic coalition that has created an independent music industry with a finanscape depending on production, distribution and consumption. While this type of music is represented through a network-based social structure, it gains legitimacy outside its bounds within the media environment. The “Ankara” genre and its quest for authenticity described in this work reveal the ideoscape of the new Ankara music.

  15. Service Quality of State Universities in Turkey: The Case of Ankara

    Science.gov (United States)

    Eres, Figen

    2011-01-01

    The aim of this study is determine the service quality perceptions of students being educated at state universities in Ankara. The sample of the study is composed of final grade students of faculties of Economics and Administrative Sciences. The sample of the study is composed of a total of randomly selected students. There were 416 returned…

  16. General scan in flavor parameter space in the models with vector quark doublets and an enhancement in $B\\to X_s\\gamma$ process

    CERN Document Server

    Wang, Wenyu; Zhao, Xin-Yan

    2016-01-01

    In the models with vector like quark doublets, the mass matrices of up and down type quarks are related. Precise diagonalization for the mass matrices became an obstacle in the numerical studies. In this work we propose a diagonalization method at first. As its application, in the standard model with one vector like quark doublet we present quark mass spectrum, Feynman rules for the calculation of $B\\to X_s\\gamma$. We find that i) under the constraints of the CKM matrix measurements, the mass parameters in the bilinear term are constrained to a small value by the small deviation from unitarity; ii) compared with the fourth generation extension of the standard model, there is an enhancement to $B\\to X_s\\gamma$ process in the contribution of vector like quark, resulting a non-decoupling effect in such models.

  17. Protective effects of a Modified Vaccinia Ankara-based vaccine candidate against Crimean-Congo Haemorrhagic Fever virus require both cellular and humoral responses

    Science.gov (United States)

    Dowall, Stuart D.; Graham, Victoria A.; Rayner, Emma; Hunter, Laura; Watson, Robert; Taylor, Irene; Rule, Antony; Carroll, Miles W.; Hewson, Roger

    2016-01-01

    Crimean-Congo Haemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. There is no approved vaccine currently available against CCHF. The most promising candidate, which has previously been shown to confer protection in the small animal model, is a modified Vaccinia Ankara virus vector expressing the CCHF viral glycoprotein (MVA-GP). It has been shown that MVA-GP induces both humoral and cellular immunogenicity. In the present study, sera and T-lymphocytes were passively and adoptively transferred into recipient mice prior to challenge with CCHF virus. Results demonstrated that mediators from both arms of the immune system were required to demonstrate protective effects against lethal challenge. PMID:27272940

  18. Protective effects of a Modified Vaccinia Ankara-based vaccine candidate against Crimean-Congo Haemorrhagic Fever virus require both cellular and humoral responses.

    Directory of Open Access Journals (Sweden)

    Stuart D Dowall

    Full Text Available Crimean-Congo Haemorrhagic Fever (CCHF is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. There is no approved vaccine currently available against CCHF. The most promising candidate, which has previously been shown to confer protection in the small animal model, is a modified Vaccinia Ankara virus vector expressing the CCHF viral glycoprotein (MVA-GP. It has been shown that MVA-GP induces both humoral and cellular immunogenicity. In the present study, sera and T-lymphocytes were passively and adoptively transferred into recipient mice prior to challenge with CCHF virus. Results demonstrated that mediators from both arms of the immune system were required to demonstrate protective effects against lethal challenge.

  19. A Modified Vaccinia Ankara Virus (MVA) Vaccine Expressing African Horse Sickness Virus (AHSV) VP2 Protects Against AHSV Challenge in an IFNAR −/− Mouse Model

    Science.gov (United States)

    Castillo-Olivares, Javier; Calvo-Pinilla, Eva; Casanova, Isabel; Bachanek-Bankowska, Katarzyna; Chiam, Rachael; Maan, Sushila; Nieto, Jose Maria; Ortego, Javier; Mertens, Peter Paul Clement

    2011-01-01

    African horse sickness (AHS) is a lethal viral disease of equids, which is transmitted by Culicoides midges that become infected after biting a viraemic host. The use of live attenuated vaccines has been vital for the control of this disease in endemic regions. However, there are safety concerns over their use in non-endemic countries. Research efforts over the last two decades have therefore focused on developing alternative vaccines based on recombinant baculovirus or live viral vectors expressing structural components of the AHS virion. However, ethical and financial considerations, relating to the use of infected horses in high biosecurity installations, have made progress very slow. We have therefore assessed the potential of an experimental mouse-model for AHSV infection for vaccine and immunology research. We initially characterised AHSV infection in this model, then tested the protective efficacy of a recombinant vaccine based on modified vaccinia Ankara expressing AHS-4 VP2 (MVA-VP2). PMID:21298069

  20. Modeling of gas demand using degree-day concept: case study for Ankara

    International Nuclear Information System (INIS)

    The demand for natural gas is rapidly increasing in Turkey, as it is in the rest of the world. However, natural gas reserves and production are rather limited in Turkey.The bulk of the Turkish gas demand is met by imports. Russia currently accounts for 69% of Turkey's gas supplies. Physical shortages might occur; supplies for industrial production and household consumption could temporarily run short. Also, fluctuations in consumption might occur due to climatic reasons or peak daily industrial energy demand. Underground gas storage is a necessity in order to regulate these seasonal, daily, and hourly fluctuations. In order to effectively design and utilize underground gas storage, it is necessary to identify the market requirements. In this study, Ankara was chosen as a pilot region due to its strategical importance of being the capital city of Turkey, and a wide range of marketing surveys for the last seven years was performed. All of the factors influencing the gas consumption and the relationships between these factors were analyzed. How does gas demand behave in extremely cold weather? How does the industrial part of the city act in the consumption behavior? What are the plans of the Municipality of Ankara, responsible for the execution of the natural gas distribution project in Ankara? A model was developed based on degree-day (DD) concept, including the annual number of customers, average DDs, and the usage per customer. A history matching study was performed to verify the results of the model with the measured consumption data for the last seven years. Comparisons showed that the calculated consumption by DD model and measured daily consumption were in good agreement. Finally, by using the developed approach, the gas demand was forecasted for Ankara up to 2005. The results of this study can be used to design underground gas storage facility near Ankara. (author)

  1. A High-Capacity Adenoviral Hybrid Vector System Utilizing the Hyperactive Sleeping Beauty Transposase SB100X for Enhanced Integration.

    Science.gov (United States)

    Boehme, Philip; Zhang, Wenli; Solanki, Manish; Ehrke-Schulz, Eric; Ehrhardt, Anja

    2016-01-01

    For efficient delivery of required genetic elements we utilized high-capacity adenoviral vectors in the past allowing high transgene capacities of up to 36 kb. Previously we explored the hyperactive Sleeping Beauty (SB) transposase (HSB5) for somatic integration from the high-capacity adenoviral vectors genome. To further improve this hybrid vector system we hypothesized that the previously described hyperactive SB transposase SB100X will result in significantly improved efficacies after transduction of target cells. Plasmid based delivery of the SB100X system revealed significantly increased integration efficiencies compared with the previously published hyperactive SB transposase HSB5. After optimizing experimental setups for high-capacity adenoviral vectors-based delivery of the SB100X system we observed up to eightfold and 100-fold increased integration efficiencies compared with the previously published hyperactive SB transposase HSB5 and the inactive transposase mSB, respectively. Furthermore, transposon copy numbers per cell were doubled with SB100X compared with HSB5 when using the identical multiplicity of infection. We believe that this improved hybrid vector system represents a valuable tool for achieving stabilized transgene expression in cycling cells and for treatment of numerous genetic disorders. Especially for in vivo approaches this improved adenoviral hybrid vector system will be advantageous because it may potentially allow reduction of the applied viral dose. PMID:27434682

  2. Vector-free and transgene-free human iPS cells differentiate into functional neurons and enhance functional recovery after ischemic stroke in mice.

    Directory of Open Access Journals (Sweden)

    Osama Mohamad

    Full Text Available Stroke is a leading cause of human death and disability in the adult population in the United States and around the world. While stroke treatment is limited, stem cell transplantation has emerged as a promising regenerative therapy to replace or repair damaged tissues and enhance functional recovery after stroke. Recently, the creation of induced pluripotent stem (iPS cells through reprogramming of somatic cells has revolutionized cell therapy by providing an unlimited source of autologous cells for transplantation. In addition, the creation of vector-free and transgene-free human iPS (hiPS cells provides a new generation of stem cells with a reduced risk of tumor formation that was associated with the random integration of viral vectors seen with previous techniques. However, the potential use of these cells in the treatment of ischemic stroke has not been explored. In the present investigation, we examined the neuronal differentiation of vector-free and transgene-free hiPS cells and the transplantation of hiPS cell-derived neural progenitor cells (hiPS-NPCs in an ischemic stroke model in mice. Vector-free hiPS cells were maintained in feeder-free and serum-free conditions and differentiated into functional neurons in vitro using a newly developed differentiation protocol. Twenty eight days after transplantation in stroke mice, hiPS-NPCs showed mature neuronal markers in vivo. No tumor formation was seen up to 12 months after transplantation. Transplantation of hiPS-NPCs restored neurovascular coupling, increased trophic support and promoted behavioral recovery after stroke. These data suggest that using vector-free and transgene-free hiPS cells in stem cell therapy are safe and efficacious in enhancing recovery after focal ischemic stroke in mice.

  3. Insulated Foamy Viral Vectors.

    Science.gov (United States)

    Browning, Diana L; Collins, Casey P; Hocum, Jonah D; Leap, David J; Rae, Dustin T; Trobridge, Grant D

    2016-03-01

    Retroviral vector-mediated gene therapy is promising, but genotoxicity has limited its use in the clinic. Genotoxicity is highly dependent on the retroviral vector used, and foamy viral (FV) vectors appear relatively safe. However, internal promoters may still potentially activate nearby genes. We developed insulated FV vectors, using four previously described insulators: a version of the well-studied chicken hypersensitivity site 4 insulator (650cHS4), two synthetic CCCTC-binding factor (CTCF)-based insulators, and an insulator based on the CCAAT box-binding transcription factor/nuclear factor I (7xCTF/NF1). We directly compared these insulators for enhancer-blocking activity, effect on FV vector titer, and fidelity of transfer to both proviral long terminal repeats. The synthetic CTCF-based insulators had the strongest insulating activity, but reduced titers significantly. The 7xCTF/NF1 insulator did not reduce titers but had weak insulating activity. The 650cHS4-insulated FV vector was identified as the overall most promising vector. Uninsulated and 650cHS4-insulated FV vectors were both significantly less genotoxic than gammaretroviral vectors. Integration sites were evaluated in cord blood CD34(+) cells and the 650cHS4-insulated FV vector had fewer hotspots compared with an uninsulated FV vector. These data suggest that insulated FV vectors are promising for hematopoietic stem cell gene therapy. PMID:26715244

  4. [Studies of Yersinia pestis in wild animals captured in Ankara, Konya and Nevsehir].

    Science.gov (United States)

    Ozsan, K; Fazli, A; Aktan, M; Beyoğlu, K

    1976-01-01

    No Yersinia pestis could be isolated, by culturing and by inoculations to 1212 guinea-pigs and 150 mice; from 623 citellus, 41 Mus musculus, 55 Microtus, 442 Meriones, 70 Rattus rattus, 56 turtle, 89 hare, 1 hamster, 1 hedgehog, 1 sea snake, altogether 790 dead, 589 alive, i.e. 1379. wild animals captured in Ankara, Konya (Karapinar), Urfa (Akçakale) and in Nevşehir. In 141 sera taken from citellus captured alive, and in 174 sera taken from guinea-pigs inoculated with spleen, liver and kidney suspensions of wild animals, 1/20 - 1/80 agglutination titers (one of the sera from a guinea-pig inoculated with hare organ suspension) were obtained. These findings, probably were due to Yersinia pseudotuberculosis, because this organism was isolated from citellus captured in Ankara and Konya. PMID:933892

  5. Taxonomy, distribution, and ecology of crustacean zooplankton in trough waters of Ankara (Turkey)

    OpenAIRE

    BAŞAK, Elif; Aygen, Cem; KÜLKÖYLÜOĞLU, OKAN

    2014-01-01

    Troughs are one of the main components of villages in Turkey. They are constructed by converting springs or underground waters. Until now, there has been no extensive study investigating the composition and diversity of trough zooplankton species. In order to contribute knowledge on the zooplanktons in troughs, 142 troughs were randomly sampled from 17 districts in Ankara Province between 22 June and 3 July 2011. A total of 18 zooplanktons including 11 Copepoda and 7 Cladocera species were de...

  6. Establıshment Of Ankara University Faculty Of Health Sciences Students Breakfast Habits

    OpenAIRE

    FAYDAOĞLU, Emine; ENERGİN, Esma; SÜRÜCÜOĞLU, Metin Saip

    2013-01-01

    The purpose of this research was to determine the breakfast habits of the students being educated in the Faculty of Health Sciences, at Ankara University. The research population consisted of ten students from each undergraduate class of the Departments of Nutrition and Diatetics, Nursing, Midwifery, Social Service and Medical Institution Management and Pediatric Development of the Faculty of Health Sciences, making up 220 voluntary students in total. The individuals who participated in the r...

  7. Determination of some yield components of winter vetch species (Vicia spp.) grown in Ankara conditions

    OpenAIRE

    KENDİR, Hayrettin

    1999-01-01

    Vetch is one of the most widespread annual legume cultivated in our country. This research was conducted to determine seed yields and to observe important characteristics of 3 winter vetch species (Vicia spp.) in Ankara conditions from 1996-1998. Common vetch (Vicia sativa) , Hungarian vetch (Vicia pannonica) and hairy vetch (Vicia villosa), grown for seed and hay in Central Anatolia, were sown in autumn and grown using standard agricultural practices. The study incorporated a randomized plo...

  8. Determination of Microbiological Quality of Ice-Cream Belong to Various Patisserie in Ankara

    OpenAIRE

    Erol, İrfan; Küplülü, Özlem; SIRIKEN, Belgin; ÇELİK, T. Halûk

    1998-01-01

    In this study, a total of 100 ice cream samples, collected from various patisserie in Ankara, 30 of them vanilla, 26 of them chocolate and 44 of them fruit ice cream samples, were analysed microbiologically. While coliform and E. coli counts were determined with MPN technique, in the isolation of the salmonella enrichment technique and in the isolation of the total viable count, lactobacilli, micrococci and staphylococci, coagulase positive staphylococci, enterobacteriaceae, enterococci, p...

  9. Recognition of cigarette brand names and logos by primary schoolchildren in Ankara, Turkey

    OpenAIRE

    Emri, S; Bagci, T.; Karakoca, Y.; Baris, E

    1998-01-01

    OBJECTIVE—To assess the smoking behaviour of primary schoolchildren and their ability to recognise brand names and logos of widely advertised cigarettes, compared with other commercial products intended for children.
DESIGN—Cross-sectional survey in classroom settings using a questionnaire designed to measure attitudes towards smoking and the recognition of brand names and logos for 16 food, beverage, cigarette, and toothpaste products.
SETTING—Ankara, Turkey.
SUBJECTS—1093 children (54.6% bo...

  10. Operational Risk Management in Hotel Establishments: A Study on Four and Five Star Hotels in Ankara

    OpenAIRE

    Elbeyi Pelit

    2011-01-01

    The purpose of this study is to determine the applications of hotel establishments in the scope of operational risk. In this context, a survey was applied to the managers of four and five star hotel establishments in Ankara/Turkey. According to the factor analysis done after the literature search and questionnaire, four risks types (staff, technological, organizational and legal risks) have been found in the scope of operational risk, and their applications towards these risk types in hotel e...

  11. Effects of Tourism on Cultural Heritage: Awareness of Local People in Beypazari,Ankara

    OpenAIRE

    Uslu, A; Kiper, T.

    2006-01-01

    This study examines the impact of tourism on residents attiude in a small community in Turkey. Thefocus is on a rural town, known as Beypazari, currently emerging as a major tourist destination for its naturaland cultural landscape in the periphery of the capitol city of Ankara. Exponential increase (almost 1000% anincrease within the last five-years) in touristic activities in the city exaburated a citizen reaction. In thisarticle; the perceptions of citiezens about the effect of tourism hav...

  12. Giulio Mongeri, an Architect Efficient in the Building of Capital City Ankara and his Biography

    Directory of Open Access Journals (Sweden)

    Damla Çinici

    2015-06-01

    Full Text Available The study is about Giulio Mongeri (1873 – 1951 who was the architect of Ottoman Bank (1926, Ziraat Bank (1926 – 1929, Monopolies Chief Directorate (1928 and Türkiye İş Bank (1929 buildings in Ankara in the first years of the Republic. Giulio Mongeri was one of the architects prominent in architectural activities both in the last years of Ottoman Empire and first years of the Republic and undertook an effective role in the architectural understanding of the next generation by raising the architects of the future as an instructor of the Academy of Fine Arts. In the study, it is aimed to gain especially the sketches and photos obtained from his diary and not published anywhere else to the scientific world as a new contribution to the knowledge in the available publications. Giulio Mongeri himself, his family and environs in which he was raised, his personality and attitude as a trainer have been appraised in the light of new information. The buildings of Mongeri in Ankara have been studied comparatively with the other buildings in Ankara in this period and an attempt is made to assess the differences in his approach.

  13. DEET microencapsulation: a slow-release formulation enhancing the residual efficacy of bed nets against malaria vectors

    NARCIS (Netherlands)

    N'Guessan, R.; Knols, B.G.J.; Pennetier, C.; Rowland, M.

    2008-01-01

    Textile materials treated with synthetic repellents have the potential to provide protection against insect disease vectors but lack the residual activity necessary to achieve a prolonged effect or to be cost-effective. DEET MC is a formulation of DEET (N,N diethyl-m-toluamide) in which the repellen

  14. Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells

    OpenAIRE

    Wang Pin; Joo Kye-Il; Froelich Steven; Tai April

    2011-01-01

    Abstract Background Dendritic cells (DCs) are antigen-presenting immune cells that interact with T cells and have been widely studied for vaccine applications. To achieve this, DCs can be manipulated by lentiviral vectors (LVs) to express antigens to stimulate the desired antigen-specific T cell response, which gives this approach great potential to fight diseases such as cancers, HIV, and autoimmune diseases. Previously we showed that LVs enveloped with an engineered Sindbis virus glycoprote...

  15. Intranasal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances Protection by Parenteral Mycobacterium bovis BCG Immunization against Pulmonary Tuberculosis

    OpenAIRE

    Santosuosso, Michael; McCormick, Sarah; Zhang, Xizhong; Zganiacz, Anna; Xing, Zhou

    2006-01-01

    Parenterally administered Mycobacterium bovis BCG vaccine confers only limited immune protection from pulmonary tuberculosis in humans. There is a need for developing effective boosting vaccination strategies. We examined a heterologous prime-boost regimen utilizing BCG as a prime vaccine and our recently described adenoviral vector expressing Ag85A (AdAg85A) as a boost vaccine. Since we recently demonstrated that a single intranasal but not intramuscular immunization with AdAg85A was able to...

  16. DEET microencapsulation : a slow-release formulation enhancing the residual efficacy of bed nets against malaria vectors

    OpenAIRE

    N'Guessan, R; Knols, B.G.J.; Pennetier, Cédric; Rowland, M

    2008-01-01

    Textile materials treated with synthetic repellents have the potential to provide protection against insect disease vectors but lack the residual activity necessary to achieve a prolonged effect or to be cost-effective. DEET MC is a formulation of DEET (N,N diethyl-m-toluamide) in which the repellent is gradually released from a capsule that binds the repellent. An experiment carried out on DEET-treated mosquito netting showed that the formulation repels, inhibits blood-feeding and kilts mosq...

  17. Evaluation of excipients for enhanced thermal stabilization of a human type 5 adenoviral vector through spray drying.

    Science.gov (United States)

    LeClair, Daniel A; Cranston, Emily D; Xing, Zhou; Thompson, Michael R

    2016-06-15

    We have produced a thermally stable recombinant human type 5 adenoviral vector (AdHu5) through spray drying with three excipient formulations (l-leucine, lactose/trehalose and mannitol/dextran). Spray drying leads to immobilization of the viral vector which is believed to prevent viral protein unfolding, aggregation and inactivation. The spray dried powders were characterized by scanning electron microscopy, differential scanning calorimetry, Karl Fischer titrations, and X-ray diffraction to identify the effects of temperature and atmospheric moisture on the immobilizing matrix. Thermal stability of the viral vector was confirmed in vitro by infection of A549 lung epithelial cells. Mannitol/dextran powders showed the greatest improvement in thermal stability with almost no viral activity loss after storage at 20°C for 90days (0.7±0.3 log TCID50) which is a significant improvement over the current -80°C storage protocol. Furthermore, viral activity was retained over short term exposure (72h) to temperatures as high as 55°C. Conversely, all powders exhibited activity loss when subjected to moisture due to amplified molecular motion of the matrix. Overall, a straightforward method ideal for the production of thermally stable vaccines has been demonstrated through spray drying AdHu5 with a blend of mannitol and dextran and storing the powder under low humidity conditions. PMID:27130366

  18. Performance Appraisal at Four and Five Star Hotels: Ankara Case

    Directory of Open Access Journals (Sweden)

    Yalçın Arslantürk

    2009-12-01

    Full Text Available Nowadays, tourism establishments developing human resources and motivating will make it easier to reach their goals and those who cannot mange to do this will be obsolete in the ever-changing nature of the tourism business. The most important feature of the tourism sector is that it is based on human element and it s labor-intensive. Hence, human element is of great importance. This being the case, the customer satisfaction in accommodation establishments will be greatly dependent on the success of the personnel. Performance appraisal in this regard is a tool used to measure the performance of the employees in establishing job satisfaction and enhancing success. Performance appraisal indicates the performance of the individuals and gives insights as to what should be done to improve the performance. As well as promoting the communication between the employees and the establishment. From the perspectives of the managers, it paves the way for an efficient information flow about the performance of the personnel and makes job planning more rationally. This study first examines performance and performance appraisal. Then, through a field study, deficiencies in the application of performance appraisal were determined in the four and five star hotel establishments. According to the results obtained, some suggestions were put forward.

  19. Vector analysis

    CERN Document Server

    Newell, Homer E

    2006-01-01

    When employed with skill and understanding, vector analysis can be a practical and powerful tool. This text develops the algebra and calculus of vectors in a manner useful to physicists and engineers. Numerous exercises (with answers) not only provide practice in manipulation but also help establish students' physical and geometric intuition in regard to vectors and vector concepts.Part I, the basic portion of the text, consists of a thorough treatment of vector algebra and the vector calculus. Part II presents the illustrative matter, demonstrating applications to kinematics, mechanics, and e

  20. About vectors

    CERN Document Server

    Hoffmann, Banesh

    1975-01-01

    From his unusual beginning in ""Defining a vector"" to his final comments on ""What then is a vector?"" author Banesh Hoffmann has written a book that is provocative and unconventional. In his emphasis on the unresolved issue of defining a vector, Hoffmann mixes pure and applied mathematics without using calculus. The result is a treatment that can serve as a supplement and corrective to textbooks, as well as collateral reading in all courses that deal with vectors. Major topics include vectors and the parallelogram law; algebraic notation and basic ideas; vector algebra; scalars and scalar p

  1. Construction of Recombinant Modified Vaccinia Ankara (MVA) Expressing Hepatitis B Virus Surface Antigen

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The T lymphocyte response has been shown to be the determinant in the clearance of many viral infections.Hence, therapeutic vaccine candidates against HBV are designed to enhance this response of the immune system.Vaccinia virus vector-based vaccines have been proposed as excellent candidates to elicit long-term and strong T lymphocyte mediated immune responses. In this study, the recombinant MVA expressing HBV surface antigen has been constructed, which can elicit a potent T cell mediated response. The ELISA results for the surface protein in the medium of the recombinant MVA, strongly indicate that the recombinant virus has been successfully obtained.

  2. An Assessment for Soft Drink Consumption of Individuals in Centre Town of Ankara Province

    OpenAIRE

    Bilge Gözener; Murat Sayılı

    2015-01-01

    In this study, the Central district of Ankara (Çankaya, Etimesgut, Gölbaşı, Keçiören, Mamak, Polatlı, Sincan and Yenimahalle districts) carbonated drink consumption situation of consumers were examined. The data obtained from questionnaires conducted with 272 families were used in this study. Data were collected in April-May 2012.Between carbonated drink consumption and some demographic characteristics of consumers were tested by chi-square analysis of whether a statistical association. Accor...

  3. Effect of Irrigation Water on Corn Grain Yield in Ankara Conditions

    OpenAIRE

    YILDIRIM, Y. Ersoy; KODAL, Süleyman

    1998-01-01

    This research was conducted in Ankara conditions in order to determine corn yield response to water. When 50% of available water content in root zone is consumed in the control treatment, irrigation water was applied to the other treatments with 0%, 25%, 50%, 75%, 125%, 150%, 175% and 200% of those applied into check plots. As a result, applications of ex-cessive water was not increased grain yields at the important level. Yield response factor (k y ) for total growing period were found a...

  4. A Survey of Bone Tumors in Dogs and Cats from 1986 to 2000 in Ankara

    OpenAIRE

    Kutsal, Osman

    2003-01-01

    In the present study, bone tumor samples obtained from 18 dogs and 21 cats from various clinics between 1986 and 2000 were clinically and pathologically examined at the Pathology Department, Faculty of Veterinary Medicine, University of Ankara. Most bone tumors examined were from 5-8-year-old dogs (43.75%) and cats (45%). A significant decrease was detected in animals over 8 years old. These tumors were observed in large breeds, mostly in German shepherd (38.4%) and Anatolian shepherd (Kanga...

  5. Prevalence and Antibiotic Resistance of Listeria Spp. Isolated from Ready-to-Eat Foods in Ankara

    OpenAIRE

    ŞİRELİ, Ufuk Tansel; GÜCÜKOĞLU, Ali

    2008-01-01

    In this study the presence of Listeria spp. is tested in 100 ready-to-eat food samples purchased from different stores and traditional food shops in the province of Ankara. The tested materials were 20 each of the following: mayonnaise based salad, kadınbudu köfte (fried meatball), fried liver, rice stuffed mussel, and green salad. Microbiological analyzes showed that 13 of 100 salad samples (13%) were contaminated with Listeria spp. while 10 of 100 salad samples (10%) were contaminated with ...

  6. Consumers’ Determination of Red Meat and Meat Products Purchase Behaviour – City of Ankara Sample

    OpenAIRE

    Hasan Arısoy; Zeki Bayramoğlu

    2014-01-01

    Nowadays, meat consuming level is an indicator of development of countries. The reason for this is the importance of animal proteins such as meat, milk and egg in human nutrition. People in Turkey do not get enough animal protein. Increase of meat and meat related product prices is effective on this. The purpose of this study is to bring up the purchase and consume behavior of consumers. Surveys completed in urban areas around city of Ankara are used primarily. Using Main Mass Ratio Based Si...

  7. Effects of Tourism on Cultural Heritage: Awareness of Local People in Beypazari,Ankara

    Directory of Open Access Journals (Sweden)

    A. Uslu

    2006-09-01

    Full Text Available This study examines the impact of tourism on residents attiude in a small community in Turkey. Thefocus is on a rural town, known as Beypazari, currently emerging as a major tourist destination for its naturaland cultural landscape in the periphery of the capitol city of Ankara. Exponential increase (almost 1000% anincrease within the last five-years in touristic activities in the city exaburated a citizen reaction. In thisarticle; the perceptions of citiezens about the effect of tourism have been examinated with random samplesurvey of residents.

  8. Adenovirus vectors lacking virus-associated RNA expression enhance shRNA activity to suppress hepatitis C virus replication

    Science.gov (United States)

    Pei, Zheng; Shi, Guoli; Kondo, Saki; Ito, Masahiko; Maekawa, Aya; Suzuki, Mariko; Saito, Izumu; Suzuki, Tetsuro; Kanegae, Yumi

    2013-12-01

    First-generation adenovirus vectors (FG AdVs) expressing short-hairpin RNA (shRNA) effectively downregulate the expressions of target genes. However, this vector, in fact, expresses not only the transgene product, but also virus-associated RNAs (VA RNAs) that disturb cellular RNAi machinery. We have established a production method for VA-deleted AdVs lacking expression of VA RNAs. Here, we showed that the highest shRNA activity was obtained when the shRNA was inserted not at the popularly used E1 site, but at the E4 site. We then compared the activities of shRNAs against hepatitis C virus (HCV) expressed from VA-deleted AdVs or conventional AdVs. The VA-deleted AdVs inhibited HCV production much more efficiently. Therefore, VA-deleted AdVs were more effective than the currently used AdVs for shRNA downregulation, probably because of the lack of competition between VA RNAs and the shRNAs. These VA-deleted AdVs might enable more effective gene therapies for chronic hepatitis C.

  9. DEET microencapsulation: a slow-release formulation enhancing the residual efficacy of bed nets against malaria vectors.

    Science.gov (United States)

    N'guessan, Raphael; Knols, Bart G J; Pennetier, Cedric; Rowland, Mark

    2008-03-01

    Textile materials treated with synthetic repellents have the potential to provide protection against insect disease vectors but lack the residual activity necessary to achieve a prolonged effect or to be cost-effective. DEET MC is a formulation of DEET (N,N diethyl-m-toluamide) in which the repellent is gradually released from a capsule that binds the repellent. An experiment carried out on DEET-treated mosquito netting showed that the formulation repels, inhibits blood-feeding and kills mosquitoes for a period of at least 6 months under laboratory conditions. Such formulations may have the potential for use on nets against pyrethroid-resistant mosquitoes or on clothing or bedding materials distributed in disasters, emergencies or refugee camp situations. PMID:18082862

  10. Elementary vectors

    CERN Document Server

    Wolstenholme, E Œ

    1978-01-01

    Elementary Vectors, Third Edition serves as an introductory course in vector analysis and is intended to present the theoretical and application aspects of vectors. The book covers topics that rigorously explain and provide definitions, principles, equations, and methods in vector analysis. Applications of vector methods to simple kinematical and dynamical problems; central forces and orbits; and solutions to geometrical problems are discussed as well. This edition of the text also provides an appendix, intended for students, which the author hopes to bridge the gap between theory and appl

  11. Trihalomethanes and associated potential cancer risks in the water supply in Ankara, Turkey

    International Nuclear Information System (INIS)

    The occurrence of trihalomethanes (THMs) in the water supply in the Ankara, Turkey was investigated. Total THMs and total organic carbon measurements were carried seasonally in the samples collected form 22 different districts along with the samples taken from the Ivedik Water Treatment Plant serving 90% of the city. The average summer nonpurgeable organic carbon (NPOC) concentration in the raw water was 4.2 mg/L, and the NPOC removal achieved in the treatment plant was 31%. The concentration of total THMs ranged from 25 to 74 μg/L, from 28 to 73 μg/L, and from 25 to 110 μg/L in winter, spring, and summer, respectively. In all of the samples chloroform existed at the highest concentrations, while bromoform was almost absent. The total THM concentrations were highest in summer for all districts. However, none of the concentrations detected exceeded the USEPA's Stage I limit of 80 μg/L and the EU's limit of 100 μg/L. However, the total THM level in 64% of the districts exceeded the USEPA's Stage II limit of 40 μg/L. The risk estimations carried out indicated that each year 1 of the 5 million Ankara residents could get cancer from the daily intake of water, mainly because of exposure to chloroform through oral ingestion

  12. Nitrogen utilization of vegetables grown under plastic greenhouse conditions in Ankara using 15N technique

    International Nuclear Information System (INIS)

    In order to find suitable varieties of tomato, pepper and cucumber for plastic greenhouse conditions in Ankara and eventually to identify the best N fertilizer rate greenhouse experiments were conducted for two years. Yazgi F1 variety for tomato, Hizir F1 variety for cucumber and Serademre 8 variety for pepper were chosen to be the suitable varieties to grow in the plastic greenhouse conditions in Ankara. Five N treatments [N0=0, N1=150, N2=300, and N3=450 kg/ha; also, soil N application treatment (Nsoil) equivalent to the fertigation treatment of 300 kg/ha was included for tomato and pepper, however N rates for cucumber was 131, 266 and 339 kg N/ha; Nsoil being 266 kg N/ha] were investigated using 15N labeled urea fertilizer. Significantly higher marketable fresh fruit and total dry matter yields and N uptakes values were obtained from N3 treatments for tomato and cucumber, but from N2 treatment for pepper. Also, significantly higher yields, N uptakes and % NUE values were obtained when the same amount of N fertilizer is applied through fertigation compared to the treatment where N fertilizer applied to the soil then drip irrigated. (author)

  13. The analysis of impact of urbanization on the bioclimatic conditions in the scale of Ankara

    Directory of Open Access Journals (Sweden)

    Necla Türkoğlu

    2012-05-01

    Full Text Available Normal 0 21 false false false TR X-NONE X-NONE In this study the biclimatological conditions of Ankara urban area have been analyzed from the data which has been acquired from areas having different land cover and use. The hourly thermal perceptions of six meteorology stations have been calculated by using the physiologically equivalent temperature (PET index that could involve not only the meteorological parameters but also human energy balance in calculations. The spatial distribution of values has been carried out by the multiple linear regression models. At the end of the analyses it is concluded that the areas which have higher built density in urban have greater PET values than the other land use classes during the most of the day. These daily mean PET difference between these areas and the grasslands is 0.4°C -1.2°C, the parks is 2.2°C-3°C, suburban is 1.4°C -2.2°C, rural is 1.7°C -2.5°C. The differences increase during night and from May to September, and decrease during daytime and from October to April. Keywords: Thermal perception, bioclimatic conditions, land use, physiologically equivalent temperature, Ankara.

  14. Vector analysis

    CERN Document Server

    Brand, Louis

    2006-01-01

    The use of vectors not only simplifies treatments of differential geometry, mechanics, hydrodynamics, and electrodynamics, but also makes mathematical and physical concepts more tangible and easy to grasp. This text for undergraduates was designed as a short introductory course to give students the tools of vector algebra and calculus, as well as a brief glimpse into these subjects' manifold applications. The applications are developed to the extent that the uses of the potential function, both scalar and vector, are fully illustrated. Moreover, the basic postulates of vector analysis are brou

  15. Subsonic longitudinal aerodynamic characteristics of a vectored-engine-over-wing configuration having spanwise leading-edge vortex enhancement

    Science.gov (United States)

    Huffman, J. K.; Fox, C. H., Jr.

    1977-01-01

    A configuration which integrates a close coupled canard wing combination, spanwise blowing for enhancement of the wing leading edge vortex, an engine-over-wing concept, and a wing trailing edge coanda-effect flap is studied. The data on the configuration are presented in tabular from without discussion. The investigation was conducted in the Langley 7- by 10-foot high speed tunnel at a Mach number of 0.166 through an angle-of-attack range from -2 to 22 deg. Rectangular main engine nozzles of aspect ratio 4, 6, and 8 were tested over a momentum coefficient range from 1.0 to 1.8.

  16. The use of layered double hydroxides as DNA vaccine delivery vector for enhancement of anti-melanoma immune response.

    Science.gov (United States)

    Li, Ang; Qin, Lili; Wang, Wenrui; Zhu, Rongrong; Yu, Yongchun; Liu, Hui; Wang, Shilong

    2011-01-01

    Our previous studies have shown that Mg:Al 1:1 layered double hydroxides (LDH(R1)) nanoparticles could be taken up by the MDDCs effectively and had an adjuvant activity for DC maturation. Furthermore, these LDH(R1) nanoparticles could up-regulate the expression of CCR7 and augment the migration of DCs in response to CCL21. In current study, we have evaluated whether LDH(R1) as DNA vaccine delivery carrier can augment the efficacy of DNA vaccine immunization in vivo. Firstly, we found that LDH(R1) was efficient in combining DNA and formed LDH(R1)/DNA complex with an average diameter of about 80-120 nm. Its high transfection efficiency in vivo delivered with a GFP expression plasmid was also observed. After delivery of pcDNA(3)-OVA/LDH(R1) complex by intradermal immunization in C57BL/6 mice, the LDH(R1) induced an enhanced serum antibody response much greater than naked DNA vaccine. Using B16-OVA melanoma as tumor model, we demonstrated that pcDNA(3)-OVA/LDH(R1) complex enhanced immune priming and protection from tumor challenge in vivo. Furthermore, we showed that LDH(R1) induced dramatically more effective CTL activation and skewed T helper polarization to Th1. Collectively, these findings demonstrate that this LDH(R1)/DNA plasmid complex should be a new and promising way in vaccination against tumor. PMID:20934217

  17. An Assessment for Soft Drink Consumption of Individuals in Centre Town of Ankara Province

    Directory of Open Access Journals (Sweden)

    Bilge Gözener

    2015-03-01

    Full Text Available In this study, the Central district of Ankara (Çankaya, Etimesgut, Gölbaşı, Keçiören, Mamak, Polatlı, Sincan and Yenimahalle districts carbonated drink consumption situation of consumers were examined. The data obtained from questionnaires conducted with 272 families were used in this study. Data were collected in April-May 2012.Between carbonated drink consumption and some demographic characteristics of consumers were tested by chi-square analysis of whether a statistical association. According to the survey; It was determined that 71.69% of the families consume carbonated drink. The vast majority of consumers (94.87%, carbonated drinks they consume more during the summer and is harmful to health (81.03% had continued to consume despite expressing. In addition, consumption of carbonated drinks with gender, age was found to be a statistically significant relationship between marital status and spouse's employment status.

  18. The frequency and effecting factors of consanguineous marriage in a group of soldiers in Ankara.

    Science.gov (United States)

    Kir, Tayfun; Güleç, Mahir; Bakir, Bilal; Hoşjgönül, Esat; Tümerdem, Nazmi

    2005-07-01

    This cross-sectional study was carried out to investigate the frequency of consanguineous marriage in a group of army conscripts in Ankara and the factors affecting this. Of 4153 soldiers, 387 were married. The rate of marriage between first cousins was found to be 19.1%, and the overall rate of consanguineous marriage was 24.1%. Consanguineous marriage was found to be significantly prevalent among soldiers who were born in and still living in the Eastern region; among those who lived in villages; among those whose parents as well as themselves had low educational levels; and among those whose marriages were arranged by their families. Neither the payment of bride-price nor the presence of consanguinity between parents was a significant factor for consanguineous marriage. In addition, the age of the soldier and the age at marriage were significantly lower among soldiers married to first cousins than among soldiers whose marriages were not consanguineous. PMID:16082860

  19. HOLIDAY HABITS OF CIVIL SERVANTS: A STUDY ON TEDAS EMPLOYEES IN ANKARA

    Directory of Open Access Journals (Sweden)

    Ayhan KARAKAŞ

    2012-06-01

    Full Text Available The purpose of this study is to detect holiday habits of officers, their motivation of going to holiday, factors effecting them to decide The research was applied on 119 civil servants working in general headquarters of TEDAŞ in Ankara by using questionnaire technique. Frequency table, Mann-Whitney U and chi-square test were used for the analysis of data. As a result of the research, it is detected that half of them spend their holidays by participating in tourism facilities; spend their free times by reading, doing sports, doing grizzle walks and having picnic; spend their holidays in resorts and hometowns; generally have holidays once a year; give the decision of holiday together with family and make their reservations directly or via travel agencies.

  20. The first Koç Han: Pioneering modern architecture in Ankara

    Directory of Open Access Journals (Sweden)

    Oya Atalay Franck

    2013-01-01

    Full Text Available Koç Holding is the most established conglomerate in Turkey. Th e company’s beginnings date from the mid 1920s, when Ahmet Vehbi Koç, founder of Koç Holding, had his first own company registered with the Ankara Chamber of Commerce. In 1932, Koç moved his business from his father’s store on Anafartalar Street to a new building, the first Koç Han, erected the same year on Çankırı Street Nr.13 in Ulus. Th e building’s designer was Swiss-Austrian architect Ernst Arnold Egli, who had come to Turkey only five years earlier upon invitation by the government to work as chief architect of the Ministry of National Education. During his stay, which lasted from 1927 until 1940, Egli realized about 40 projects and worked on many more. Koç Han is the rare example of a commercial building by Egli. At a time when the urban aspect of the old town center of Ankara consisted mostly of one-or two-storeyed stone-and-wood houses, the first Koç Han represented an altogether new building type for the town, in being a multipurpose edifice with space for shops at street level, with large storage facilities below ground, and providing off ices and housing on the upper fl oors. Th e functional rigor of the plan and the sober modernism of the building’s facades contrasted strongly with the architecture of the time. In this respect, the first Koç Han was a strong statement regarding Ahmet Vehbi Koç’s belief in a modern Turkey and to the contribution of the building’s architect, Ernst Arnold Egli, to this project.

  1. Association of Some Environmental Factors with Breath Carbon Monoxide Levels of Some Taxi Drivers in Ankara

    Directory of Open Access Journals (Sweden)

    Oguz Baran

    2010-12-01

    Full Text Available AIM: Taxi drivers are among the occupational groups with the highest smoking prevalence and exposure to carbon monoxide (CO. This study aimed to measure breath CO levels of some taxi drivers working in Ankara and to find out some associated factors (if any. METHOD: The descriptive study was carried out with 173 taxi drivers from 14 different taxi stations in the center of Ankara. Data was collected by face to face interviews with a standart questionnaire, while breath CO was measured by a Pi-CO Smokerlyser. Descriptive statistics were used to summarize data, whereas chi-square, independant samples t-test and One-Way ANOVA were used to compare groups by SPSS 15.0 statistical package programme. RESULTS: In the study, all of the taxi drivers (n=173 were male with a mean age of 39.2±9.6 years. Of the drivers, 58.4% were current smokers, whereas 75.1% were exposed to enviromental tobacco smoke. The frequency of indoor smoking in the taxi stations, taxis and drivers’ homes were 48.0%, 45.1%, and 59.0%, respectively. The mean breath CO level of the drivers was 16.9±12.8 ppm. CO level was positively associated with the current smoking status, total years of smoking, number of cigarettes smoked per day and passive exposure to tobacco smoke, whereas the association was negative with the elapsed time from the last cigarette smoked (p0.05. CONCLUSION: Results of the study provide evidence in support of the previous literature that smoking is one of the most important sources of carbonmonoxide. Interventions such as awareness raising trainings, referral of smokers willing to quit smoking to smoking cessation centers and screening programmes for smoking related diseases are needed to be implemented in collaboration with the relevant drivers’ associations. [TAF Prev Med Bull 2010; 9(6.000: 591-596

  2. Production of Transgenic Korean Native Cattle Expressing Enhanced Green Fluorescent Protein Using a FIV-Based Lentiviral Vector Injected into MII Oocytes

    Institute of Scientific and Technical Information of China (English)

    Yong-Nan Xu; Joon-Ho Yoon; Dae-Hwan Ko; Teoan Kim; Nam-Hyung Kim; Sang-Jun Uhm; Bon-Chul Koo; Mo-Sun Kwon; Ji-Yeol Roh; Jung-Seok Yang; Hyun-Yong Choi; Young-Tae Heo; Xiang-Shun Cui

    2013-01-01

    The potential benefits of generating and using transgenic cattle range from improvements in agriculture to the production of large quantities of pharmaceutically relevant proteins.Previous studies have attempted to produce transgenic cattle and other livestock by pronuclear injection and somatic cell nuclear transfer,but these approaches have been largely ineffective; however,a third approach,lentivirus-mediated transgenesis,has successfully produced transgenic livestock.In this study,we generated transgenic (TG) Korean native cattle using perivitelline space injection of viral vectors,which expressed enhanced green fluorescent protein (EGFP) systemically.Two different types of lentiviral vectors derived from feline immunodeficiency virus (FIV) and human immunodeficiency virus (HIV)carrying EGFP were injected into the perivitelline space of MII oocytes.EGFP expression at 8-cell stage was significantly higher in the FIV group compared to the HIV group (47.5% ± 2.2% v.s.22.9% ± 2.9%).Eight-cell embryos that expressed EGFP were cultured into blastocysts and then transferred into 40 heifers.Ten heifers were successfully impregnated and delivered 10 healthy calves.All of these calves expressed EGFP as detected by in vivo imaging,PCR and Southern blotting.In addition,we established an EGFP-expressing cell line from TG calves,which was followed by nuclear transfer (NT).Recloned 8-cell embryos also expressed EGFP,and there were no differences in the rates of fusion,cleavage and development between cells derived from TG and non-TG calves,which were subsequently used for NT.These results illustrate that FIV-based lentiviruses are useful for the production of TG cattle.Moreover,our established EGFP cell line can be used for additional studies that involve induced pluripotent stem cells.

  3. Construction of a bicistronic recombinant adenoviral vector for human interleukin-10 and enhanced green fluorescent protein expression in bone marrow mesenchymal stem cells

    Institute of Scientific and Technical Information of China (English)

    LIN Jian-qing; LIN Cai-zhu; LIN Xian-zhong; ZENG Kai; GAO You-guang

    2012-01-01

    Background Human interleukin-10 (hlL-10) is a cytokine synthesis inhibitory factor,which is involved in various immune responses.The purpose of this study was to construct an adenoviral vector carrying the hlL-10 gene for expression of biologically active hlL-10 in rat bone marrow mesenchymal stem cells (rMSCs).Methods A pSNAV2.0-hlL10 plasmid was used as a template to obtain a hlL-10 cDNA fragment that was subcloned by restriction enzyme digestion and ligation into a pDC316-IRES-EGFP-lacZ alpha plasmid carrying an enhanced green fluorescent protein (EGFP) marker gene.The pDC316-hlL-10-IRES-EGFP plasmid was linearized by Pmel digestion and used to transfect HEK293 packaging cells using the adenovirus packaging system AdMax.Virus particles were amplified by repeatedly infecting HEK293 cells with the seed virus and then purified by ion exchange.After the number of virus particles and titer was determined,rMSCs were infected with the adenoviral vector.The infection rate was determined by fluorescence microscopy and flow cytometry,and hlL-10 protein expression in rMSCs was measured by Western blotting.Results The virus particle concentration,OD260/280 value and virus titer of the amplified and purified recombinant adenovirus were 3.2×1011 VP/ml,approximately 2.0,and 1.1×1010 TCID50/ml,respectively.Bright green fluorescence was observed by fluorescence microscopy and flow cytometry in the recombinant adenovirus-infected rMSCs.GFP expression was considered the multiplicity of infection (MOI) and was time-dependent.The infection rate was 92.9% at 100 MOI.Conclusions A bicistrenic recombinant adenoviral vector for hlL-10 and EGFP gene expression were successfully constructed.The infection rate of rMSCs by the adenovirus was high (92.9% at 100 MOI) and the target gene hlL-10 was highly expressed in cells.The present study provides an experimental basis for further research of immunosuppressive therapy using hlL-10.The expression level of hlL-10 protein as detected by

  4. A Viral Vectored Prime-Boost Immunization Regime Targeting the Malaria Pfs25 Antigen Induces Transmission-Blocking Activity

    OpenAIRE

    Goodman, Anna L.; Blagborough, Andrew M.; Sumi Biswas; Yimin Wu; Hill, Adrian V.; Sinden, Robert E.; Draper, Simon J

    2011-01-01

    The ookinete surface protein Pfs25 is a macrogamete-to-ookinete/ookinete stage antigen of Plasmodium falciparum, capable of exerting high-level anti-malarial transmission-blocking activity following immunization with recombinant protein-in-adjuvant formulations. Here, this antigen was expressed in recombinant chimpanzee adenovirus 63 (ChAd63), human adenovirus serotype 5 (AdHu5) and modified vaccinia virus Ankara (MVA) viral vectored vaccines. Two immunizations were administered to mice in a ...

  5. Cloning vector

    Science.gov (United States)

    Guilfoyle, Richard A.; Smith, Lloyd M.

    1994-01-01

    A vector comprising a filamentous phage sequence containing a first copy of filamentous phage gene X and other sequences necessary for the phage to propagate is disclosed. The vector also contains a second copy of filamentous phage gene X downstream from a promoter capable of promoting transcription in a bacterial host. In a preferred form of the present invention, the filamentous phage is M13 and the vector additionally includes a restriction endonuclease site located in such a manner as to substantially inactivate the second gene X when a DNA sequence is inserted into the restriction site.

  6. Electroporation and lipid nanoparticles with cyanine IR-780 and flavonoids as efficient vectors to enhanced drug delivery in colon cancer.

    Science.gov (United States)

    Kulbacka, Julita; Pucek, Agata; Kotulska, Małgorzata; Dubińska-Magiera, Magda; Rossowska, Joanna; Rols, Marie-Pierre; Wilk, Kazimiera Anna

    2016-08-01

    Nanocarriers and electroporation (also named electropermeabilization) are convenient methods to increase drug transport. In the current study, we present an effective support of drug delivery into cancer cells, utilizing these methods. We compare the efficiency of each of them and their combination. Multifunctional solid lipid nanoparticles (SLNs) loaded with a cyanine-type IR-780 - acting as a diagnostic agent and a photosensitizer, and a flavonoid derivative - baicalein (BAI) or fisetin (FIS) as a therapeutic cargo - were fabricated via solvent-diffusion method. A therapy supplemented with flavonoids may provide a more precise method to apply desirable lower drug doses and is more likely to result in lower toxicity and a decrease in tumor growth. The SLNs were stabilized with Phospholipon 90G at various concentrations; cetyl palmitate (CP) was applied as a solid matrix. The obtained nanosystems were characterized by dynamic light scattering (size along with size distribution), UV-vis (cargos encapsulation efficiency) and atomic force microscopy (morphology and shape). The obtained SLNs were used as drug carriers alone and in combination with electropermeabilization induced by millisecond pulsed electric fields of high intensity. Two cell lines were selected for the study: LoVo and CHO-K1. The viability was assessed after electroporation alone, the use of electroporation and nanoparticles, and nanoparticles or drugs alone. The intracellular accumulation of cyanine IR-780 and the impact on intracellular structure organization of cytoskeleton was visualized with confocal microscopy method with alpha-actin and beta-tubulin. In this study, the efficacy of nanoparticles with mixed cargo, additionally enhanced by electroporation, is demonstrated to act as an anticancer modality to eliminate cancer cells. PMID:26946158

  7. Equivalent Vectors

    Science.gov (United States)

    Levine, Robert

    2004-01-01

    The cross-product is a mathematical operation that is performed between two 3-dimensional vectors. The result is a vector that is orthogonal or perpendicular to both of them. Learning about this for the first time while taking Calculus-III, the class was taught that if AxB = AxC, it does not necessarily follow that B = C. This seemed baffling. The…

  8. Study on spectral parameters and the support vector machine in surface enhanced Raman spectroscopy of serum for the detection of colon cancer

    Science.gov (United States)

    Li, Xiaozhou; Yang, Tianyue; Li, Siqi; Yao, Jun; Song, Youtao; Wang, Deli; Ding, Jianhua

    2015-11-01

    Surface enhanced Raman spectroscopy (SERS) has been recognized as an effective tool for the analysis of tissue samples and biofluids. In this work, a total of 27 spectral parameters were chosen and compared using SERS. Four parameters with the highest prediction ability were selected for further support vector machine (SVM) analysis. As a comparison, principal component analysis (PCA) was used on the same dataset for feature extraction. SVM was used with the above two data reduction methods separately to differentiate colon cancer and the control groups. Serum taken from 52 colon cancer patients and 60 healthy volunteers were collected and tested by SERS. The accuracy for Parameter-SVM was 95.0%, the sensitivity was 96.2%, and the specificity was 95.5%, which was much higher than the results using only one parameter, while for PCA-SVM, the results are 93.3%, 92.3%, and 92.9%, respectively. These results demonstrate that the SERS analysis method can be used to identify serum differences between colon cancer patients and normal people.

  9. Co-expression of the C-terminal domain of Yersinia enterocolitica invasin enhances the efficacy of classical swine-fever-vectored vaccine based on human adenovirus

    Indian Academy of Sciences (India)

    Helin Li; Pengbo Ning; Zhi Lin; Wulong Liang; Kai Kang; Lei He; Yanming Zhang

    2015-03-01

    The use of adenovirus vector-based vaccines is a promising approach for generating antigen-specific immune responses. Improving vaccine potency is necessary in other approaches to address their inadequate protection for the majority of infectious diseases. This study is the first to reconstruct a recombinant replication-defective human adenovirus co-expressing E2 and invasin C-terminal (InvC) glycoproteins (rAd-E2-InvC). rAd-E2-InvC with 2×106 TCID50 was intramuscularly administered two times to CSFV-free pigs at 14 day intervals. No adverse clinical reactions were observed in any of the pigs after the vaccination. The CSFV E2-specific antibody titer was significantly higher in the rAd-E2-InvC group than that in the rAdV-E2 group as measured by NPLA and blocking ELISA. Pigs immunized with rAd-E2-InvC were completely protected against lethal challenge. Neither CSFV RNA nor pathological changes were detected in the tissues after CSFV challenge. These results demonstrate that rAd-E2-InvC could be an alternative to the existing CSF vaccine. Moreover, InvC that acts as an adjuvant could enhance the immunogenicity of rAdV-E2 and induce high CSFV E2-specific antibody titer and protection level.

  10. English-language needs in the probable work situations of the students of the Radio, Television, and Film Department at Ankara University

    OpenAIRE

    Şahin, Z Zeynep

    1994-01-01

    Ankara : Institute of Humanities and Letters of Bilkent Univ., 1994. Thesis (Master's) -- -Bilkent University, 1994. Includes bibliographical references leaves 63-65. This study was designed to investigate the fututre work-related English language needs of the students of the Radio, Television, and Film Department (RTFD) at the Faculty of Communication (FC) at Ankara University (AU). With this purpose, a needs analysis was conducted at Turkish Radio Television Corporation (TRT) whic...

  11. Vaccine efficacy against malaria by the combination of porcine parvovirus-like particles and vaccinia virus vectors expressing CS of Plasmodium.

    Directory of Open Access Journals (Sweden)

    Dolores Rodríguez

    Full Text Available With the aim to develop an efficient and cost-effective approach to control malaria, we have generated porcine parvovirus-like particles (PPV-VLPs carrying the CD8(+ T cell epitope (SYVPSAEQI of the circumsporozoite (CS protein from Plasmodium yoelii fused to the PPV VP2 capsid protein (PPV-PYCS, and tested in prime/boost protocols with poxvirus vectors for efficacy in a rodent malaria model. As a proof-of concept, we have characterized the anti-CS CD8(+ T cell response elicited by these hybrid PPV-VLPs in BALB/c mice after immunizations with the protein PPV-PYCS administered alone or in combination with recombinant vaccinia virus (VACV vectors from the Western Reserve (WR and modified virus Ankara (MVA strains expressing the entire P. yoelii CS protein. The results of different immunization protocols showed that the combination of PPV-PYCS prime/poxvirus boost was highly immunogenic, inducing specific CD8+ T cell responses to CS resulting in 95% reduction in liver stage parasites two days following sporozoite challenge. In contrast, neither the administration of PPV-PYCS alone nor the immunization with the vectors given in the order poxvirus/VLPs was as effective. The immune profile induced by VLPs/MVA boost was associated with polyfunctional and effector memory CD8+ T cell responses. These findings highlight the use of recombinant parvovirus PPV-PYCS particles as priming agents and poxvirus vectors, like MVA, as booster to enhance specific CD8+ T cell responses to Plasmodium antigens and to control infection. These observations are relevant in the design of T cell-inducing vaccines against malaria.

  12. The Rates of Undergoing Cancer Screening Among Family Physicians Aged 40 and Older Working in Ankara Province

    OpenAIRE

    Ayşe Selda Tekiner; Gülseren Lale; A. Gülsen Ceyhun Peker2

    2016-01-01

    Aim: Family physicians, as role models for their patients, self health behaviors are important. We aimed to investigate the rate of undergoing cancer screening among family physicians. Methods: This is a descriptive and questionnaire-based study. Although we aimed to interview 1100 family physicians aged 40 or older working at family health centers of Ankara, the study was performed with 453 physicians. The questionnaire form comprised of the doctors’ opinions about cancer s...

  13. Longhorned Beetles Collection of the Entomology Museum of Central Anatolia Forestry Research Directorship, Ankara, Turkey (Coleoptera,Cerambycidae)

    OpenAIRE

    ÖZDİKMEN, Hüseyin; ŞAHİN, Özlem

    2010-01-01

    In the present paper, specimens of Cerambycidae were examined in the Entomology Museum of Central Anatolia Forestry Research Directorship, Ankara, Turkey. As a result of identification of these specimens, thirty-eight species and two subspecies belonging to twenty-eight genera of five subfamilies were determined. With this paper, new faunistic data and some zoogeographical evaluations were presented on longhorned beetles fauna (Coleoptera, Cerambycidae) of Turkey. The faunistic data in the pr...

  14. A Study on the Anthropometric Measures, Breast feeding and Nutrition Status of Children of 0 36 Months Living in Ankara

    OpenAIRE

    ŞANLIER, Nevin; AYTEKİN, Fulya

    2004-01-01

    Various diseases can be prevented at an early period by using anthropometric measures to determine undernourishment and malnutrition and to follow growth in children. This study was planned and implemented to examine the physical development of children of 0-3 ages. 679 children applying to 15 Mother and Child Health and Family Planning Centers and District Health Centers in different quarters of Ankara were studied. Midwives and nurses working in these centers properly measured heights ...

  15. The Relationship between Market Orientation, Innovation Orientation and Firm Performance: A Research in Four and Five Star Hotels in Ankara

    OpenAIRE

    ERDEM, Barış; Kudret GÜL; Melike GÜL

    2013-01-01

    In this study, relationships between market orientation, innovation orientation and firm performance were researched. As samples, four and five star hotel enterprises in Ankara were selected. Research data were obtained from senior managers of 40 hotel enterprises by using questionnaire technique. According to findings, it was detected that market orientation and innovation orientation have significant and positive oriented relations with firm performance. A significant and positive orien...

  16. Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis.

    Directory of Open Access Journals (Sweden)

    Zhou Xing

    Full Text Available BACKGROUND: Recombinant adenovirus-vectored (Ad tuberculosis (TB vaccine platform has demonstrated great potential to be used either as a stand-alone or a boost vaccine in murine models. However, Ad TB vaccine remains to be evaluated in a more relevant and sensitive guinea pig model of pulmonary TB. Many vaccine candidates shown to be effective in murine models have subsequently failed to pass the test in guinea pig models. METHODS AND FINDINGS: Specific pathogen-free guinea pigs were immunized with BCG, AdAg85A intranasally (i.n, AdAg85A intramuscularly (i.m, BCG boosted with AdAg85A i.n, BCG boosted with AdAg85A i.m, or treated only with saline. The animals were then infected by a low-dose aerosol of M. tuberculosis (M.tb. At the specified times, the animals were sacrificed and the levels of infection in the lung and spleen were assessed. In separate studies, the long-term disease outcome of infected animals was monitored until the termination of this study. Immunization with Ad vaccine alone had minimal beneficial effects. Immunization with BCG alone and BCG prime-Ad vaccine boost regimens significantly reduced the level of M.tb infection in the tissues to a similar extent. However, while BCG alone prolonged the survival of infected guinea pigs, the majority of BCG-immunized animals succumbed by 53 weeks post-M.tb challenge. In contrast, intranasal or intramuscular Ad vaccine boosting of BCG-primed animals markedly improved the survival rate with 60% of BCG/Ad i.n- and 40% of BCG/Ad i.m-immunized guinea pigs still surviving by 74 weeks post-aerosol challenge. CONCLUSIONS: Boosting, particularly via the intranasal mucosal route, with AdAg85A vaccine is able to significantly enhance the long-term survival of BCG-primed guinea pigs following pulmonary M.tb challenge. Our results thus support further evaluation of this viral-vectored TB vaccine in clinical trials.

  17. Water utilization of vegetables grown under plastic greenhouse conditions in Ankara using neutron probe technique

    International Nuclear Information System (INIS)

    In order to find suitable varieties of tomato, pepper and cucumber for plastic greenhouse conditions in Ankara and ensure both higher yields and lower NO3 leaching greenhouse experiments were conducted for three years. In the first year (2001) of the experiment four different varieties from each vegetable, namely, Tomato (Ecem F1, 9920 F1, 2116 F1 and Yazg1 F1), Cucumber (Hizir F1 , Rapido, Hana, and Luna) and Pepper (1245 F1, 730 F1, Serademre 8 and 710 F1) had been grown in the plastic greenhouse using drip irrigation-fertilization system. Yazg1 F1 variety for tomato, Hizir F1 variety for cucumber and Serademre 8 variety for pepper were chosen to be suitable varieties to grow in the plastic greenhouse conditions in Ankara. One access tube in each N3 and N0 treatment plots of tomato, cucumber and pepper in 2002 and 2003 experiments were installed for the soil moisture determinations at 30, 60 and 90 cm depths. Readings with the neutron probe were taken before planting and after harvest for the water consumption calculations using the water balance approach and the WUE was calculated on the basis of the ratio of dry matter weight to the amount of water consumed. Tensiometer and suction cups were installed at 15, 30, 45 and 60 cm depths only to N1, N2 and N3 treatments plots of each vegetable in 2002 and 2003. Tensiometer readings were taken just before irrigation. Also, soil solution samples from suction cups were taken at final harvest and NO3 determinations were done with RQFLEX nitrate test strips. Significantly higher yields and WUE values were obtained when the same amount of N fertilizer is applied through fertigation compared to the treatment where N fertilizer applied to the soil then drip irrigated. The nitrate concentrations of the soil solution increased as the N rates increased and no NO3 had been found in the soil solution taken from 75 cm soil depth, indicating that no leaching of N fertilizer occurred beyond 75 cm soil depth. (author)

  18. A proton irradiation test facility for space research in Ankara, Turkey

    Science.gov (United States)

    Gencer, Ayşenur; Yiǧitoǧlu, Merve; Bilge Demirköz, Melahat; Efthymiopoulos, Ilias

    2016-07-01

    Space radiation often affects the electronic components' performance during the mission duration. In order to ensure reliable performance, the components must be tested to at least the expected dose that will be received in space, before the mission. Accelerator facilities are widely used for such irradiation tests around the world. Turkish Atomic Energy Authority (TAEA) has a 15MeV to 30MeV variable proton cyclotron in Ankara and the facility's main purpose is to produce radioisotopes in three different rooms for different target systems. There is also an R&D room which can be used for research purposes. This paper will detail the design and current state of the construction of a beamline to perform Single Event Effect (SEE) tests in Ankara for the first time. ESA ESCC No.25100 Standard Single Event Effect Test Method and Guidelines is being considered for these SEE tests. The proton beam kinetic energy must be between 20MeV and 200MeV according to the standard. While the proton energy is suitable for SEE tests, the beam size must be 15.40cm x 21.55cm and the flux must be between 10 ^{5} p/cm ^{2}/s to at least 10 ^{8} p/cm ^{2}/s according to the standard. The beam size at the entrance of the R&D room is mm-sized and the current is variable between 10μA and 1.2mA. Therefore, a defocusing beam line has been designed to enlarge the beam size and reduce the flux value. The beam line has quadrupole magnets to enlarge the beam size and the collimators and scattering foils are used for flux reduction. This facility will provide proton fluxes between 10 ^{7} p/cm ^{2}/s and 10 ^{10} p/cm ^{2}/s for the area defined in the standard when completed. Also for testing solar cells developed for space, the proton beam energy will be lowered below 10MeV. This project has been funded by Ministry of Development in Turkey and the beam line construction will finish in two years and SEE tests will be performed for the first time in Turkey.

  19. [Atmospheric concentration of fungus spores in Ankara and the effect of meteorological factors in 2003 period].

    Science.gov (United States)

    Ceter, Talip; Pinar, Nur Münevver

    2009-10-01

    The atmospheric concentrations of airborne fungus spores change continuously according to the meteorological factors, and their intensity have important allergic effects on atopic subjects and opportunistic pathogenic effects on immunocompromised patients. The aim of this study was to identify the fungal spores found in Ankara atmosphere during 2003 period and to investigate the changes in spore concentrations in relation to meteorological factors. Fungal spores were sampled by using 7-day Burkard volumetric trap between January to December 2003, and probable identification was performed microscopically based on their morphological structures. A total of 433.079 spores/m3 belonging to 35 taxa were observed during the study. The rates of these taxa were as follows; 75.5% Cladosporium, 6.1% Alternaria, 2.2% Leptosphaeria, 2.2% Ustilago, 2.1% 1-septate ascospores, 2% Exosporium, 1.6% Pleospora, and 1.3% Drechslera. The other taxa with concentrations Peronospora, Venturia, Paraphaeosphaeria, Epicoccum, Didymella, Chaetomium and Fusarium rates between 0.7-0.1%; Oidium, Xylaria, Botrytis, Melanospora, Dictyosporium, Sporormiella and Tetracoccosporium rates between 0.09-0.01%). Although fungal spores were detected in all months in Ankara atmosphere, the evaluation of the seasonal distribution of spore concentrations revealed that the highest value was detected in July (100.697 spores/m3), while the lowest value was in January (4268 spores/m3). When the effects of meteorological factors on spore concentrations were investigated, it was found that, monthly mean temperature (> 20 degrees C) has a strong positive correlation (p < 0.01), and monthly mean relative humidity (< %50) and precipitation (0-20 mm) have strong negative correlations (p < 0.01) on the spore concentrations, while wind velocity (3 m/s) has a slightly positive effect. An annual spore calendar which indicated weekly concentrations and allergenicity levels of those identified fungal spores, was also prepared

  20. Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain.

    Directory of Open Access Journals (Sweden)

    Alexandra J Spencer

    Full Text Available The orthodox role of the invariant chain (CD74; Ii is in antigen presentation to CD4+ T cells, but enhanced CD8+ T cells responses have been reported after vaccination with vectored viral vaccines encoding a fusion of Ii to the antigen of interest. In this study we assessed whether fusion of the malarial antigen, ME-TRAP, to Ii could increase the vaccine-induced CD8+ T cell response. Following single or heterologous prime-boost vaccination of mice with a recombinant chimpanzee adenovirus vector, ChAd63, or recombinant modified vaccinia virus Ankara (MVA, higher frequencies of antigen-specific CD4+ and CD8+ T cells were observed, with the largest increases observed following a ChAd63-MVA heterologous prime-boost regimen. Studies in non-human primates confirmed the ability of Ii-fusion to augment the T cell response, where a 4-fold increase was maintained up to 11 weeks after the MVA boost. Of the numerous different approaches explored to increase vectored vaccine induced immunogenicity over the years, fusion to the invariant chain showed a consistent enhancement in CD8+ T cell responses across different animal species and may therefore find application in the development of vaccines against human malaria and other diseases where high levels of cell-mediated immunity are required.

  1. Vector geometry

    CERN Document Server

    Robinson, Gilbert de B

    2011-01-01

    This brief undergraduate-level text by a prominent Cambridge-educated mathematician explores the relationship between algebra and geometry. An elementary course in plane geometry is the sole requirement for Gilbert de B. Robinson's text, which is the result of several years of teaching and learning the most effective methods from discussions with students. Topics include lines and planes, determinants and linear equations, matrices, groups and linear transformations, and vectors and vector spaces. Additional subjects range from conics and quadrics to homogeneous coordinates and projective geom

  2. The Immunogenicity of the Tumor-Associated Antigen α-Fetoprotein Is Enhanced by a Fusion with a Transmembrane Domain

    Directory of Open Access Journals (Sweden)

    Lucile Tran

    2012-01-01

    Full Text Available Aim. To investigate the ability of recombinant modified vaccinia virus Ankara (rMVA vector to induce an immune response against a well-tolerated self-antigen. Methods. rMVA vectors expressing different form of α-fetoprotein (AFP were produced and characterized. Naïve mice were vaccinated with MVA vectors expressing the AFP antigen in either a secreted, or a membrane-bound, or an intracellular form. The immune response was monitored by an IFNΓ ELISpot assay and antibody detection. Results. Vaccination with the membrane-associated form of AFP induced a stronger CD8+ T-cell response compared to the ones obtained with the MVA encoding the secreted or the intracellular forms of AFP. Moreover, the vaccination with the membrane-bound AFP elicited the production of AFP-specific antibodies. Conclusions. The AFP transmembrane form is more immunogenic. Expressing a membrane-bound form in the context of an MVA vaccination could enhance the immunogenicity of a self-antigen.

  3. Separation of hydrograph components using stable isotopes case study: Guvenc basin, Ankara

    International Nuclear Information System (INIS)

    In this paper, a stable environmental isotope study was carried out from analysis of water samples collected from rainfall, runoff (total discharge), springs (subsurface flows), and wells (groundwater) between 1996-2000. The research site was Guvenc basin located near Yenimahalle-Ankara having a drainage area of about 16.125 km2 . There are many representative hydrologic basins established in Turkey by the General Directorate of Rural Services (GDRS). In these basins, the precipitation and runoff values are recorded continuously and relationship between these values are also investigated in the last ten-twenty years. Guvenc basin, the study area, is one of these representative basins. On this basin, a stream gaging, station and five rain gages have been installed to collect and analyze runoff and rainfall data. A small dam was constructed at the outlet of the basin to store and provide water for distribution to agricultural areas. The characteristics of precipitation data are collected at raingage station, installed near the runoff measuring. To monitor the groundwater isotopic composition regular samples are also collected from a dug well near runoff station

  4. Analysis of Ankara urban area from human bioclimatologic point of view

    Directory of Open Access Journals (Sweden)

    Necla Türkoğlu

    2011-10-01

    Full Text Available In this study, the Physiological Equivalent Temperatures (PET of different land patterns in the Ankara urban area has been analyzed. The spatial distribution and temporal variation of the thermal perceptions and the grades of thermal stress caused by the thermal conditions have been determined for 00:00, 03:00, 06:00, 09:00, 12:00, 15:00, 18:00 and 21:00 hours during the December and July of 2010. The effects of physiographic features such as elevation, aspect, slope, and especially land use, on the PETs have also been examined. According to the analysis which is carried out by using PET thermal perception index, in the research area the thermal comfort values varies around from -6 to -11°C in winter and from 13°C to 50°C in summer. In both periods the open spaces (grasslands of the city forests have the maximum PET values during the day. Either in December and in July the urban area (city center has and cool island during the day and has a heat island during the night.

  5. Consumer Decision - Making Process in E - Commerce: Case of Salzburg - Ankara

    Directory of Open Access Journals (Sweden)

    Ahmet Gürbüz

    2015-09-01

    Full Text Available In a globalized world, companies need to track the changes occur in their internal and external stakeholders in order to develop consistent strategies, structures and systems for success in e-commerce. Tracking and researching the existing and potential customers and companies as external stakeholders has become very important. This study aims to reveal a scientific approach about the purchasing decisions of e-commerce companies’ customers, to carry the e-commerce applications in Austria to Turkey, to transfer the e-commerce applications in Turkey to Austria and to contribute for the development of e-commerce. To achieve this, in-depth interviews were conducted with 16 female e-commerce users in Ankara/Turkey and in Salzburg/Austria to reveal the similarities and differences between the purchasing decision processes of different countries’ citizens. Similarities and differences in the purchasing decision process of customers were determined for the dimensions of price compatibility, practicality, accessibility, speed, comfort, convenience and cost and suggestions are offered for the development of e-commerce in Turkey.

  6. Consumers’ Determination of Red Meat and Meat Products Purchase Behaviour – City of Ankara Sample

    Directory of Open Access Journals (Sweden)

    Hasan Arısoy

    2014-08-01

    Full Text Available Nowadays, meat consuming level is an indicator of development of countries. The reason for this is the importance of animal proteins such as meat, milk and egg in human nutrition. People in Turkey do not get enough animal protein. Increase of meat and meat related product prices is effective on this. The purpose of this study is to bring up the purchase and consume behavior of consumers. Surveys completed in urban areas around city of Ankara are used primarily. Using Main Mass Ratio Based Simple Occurrence Probability Sampling method 338 families were interviewed. Completed surveys were separated into 3 groups; high, middle, low. As a result of the research, expense for food in total income is around %34. This ratio for families with low income is %53, for families with middle income is %35 and for families with high income is %33. It is found that as income levels of consumers raised, food expenses raise as well. But it shows that as income level increases, expense ratio for food decreases. Food reliability is the most effective factor on consumers’ decision of purchase. Studies show doubts of consumers about food reliability. It is understood that legal adjustments are not applied enough. Especially tight food inspections would be positive on consumer behavior.

  7. On-going research projects at Ankara Nuclear Research Center in Agriculture and Animal Science

    International Nuclear Information System (INIS)

    Full text: The research and development activities of Ankara Nuclear Research Center in Agriculture and Animal Science(ANRCAA) are concentrated on the contribution of atomic energy to peace by the use of nuclear and related techniques in food, agriculture and animal science. Nuclear techniques are used in the above fields in two ways: in vitro or in vivo radio tracing the substances and processes of biological importance, and irradiation of biological materials for preservation and quality modification. Research projects are carried out by interdisciplinary studies with well equipped laboratories at the Center. The projects in progress conducted by the Center comprises nuclear-aided researches in soil fertility, plant nutrition, plant protection, improvement of field crops, improvement of horticultural plants and forest trees by mutation breeding, in vitro culture technique with mutagen treatments, use of phosphogypsum in soil amelioration, sterilization of medical supplies, wastewater treatment, animal nutrition, animal health and productivity and accreditation. The on-going projects with the above subjects will be summarized for possible collaborations

  8. Seasonal variation of surface temperature based on land cover in Ankara

    Directory of Open Access Journals (Sweden)

    İhsan Çiçek

    2013-03-01

    Full Text Available In this study, the seasonal variation of the surface temperature of Ankara urban area and its enviroment have been analyzed by using Landsat 7 image. The Landsat 7 images of each month from 2007 to 2011 have been used to analyze the annually changes of the surface temperature. The land cover of the research area was defined with supervised classification method on the basis of the satellite image belonging to 2008 July. After determining the surface temperatures from 6-1 bands of satellite images, the monthly mean surface temperatures were calculated for land cover classification for the period between 2007 and 2011. Accordşng to the results obtained, the surface temperatures are high in summer and low in winter from the air temperatures. all satellite images were taken at 10:00 am, it is found that urban areas are cooler than rural areas at 10:00 am. Regarding the land cover classification, the water surfaces are the coolest surfaces during the whole year. The warmest areas are the grasslands and dry farming areas. While the parks are warmer than the urban areas during the winter, during the summer they are cooler than artificial land covers. The urban areas with higher building density are the cooler surfaces after water bodies.

  9. Researches on Hygienic Qualities of Airan and Yoghurt Samples Sold in Ankara Markets (in Turkish)

    OpenAIRE

    Duru, Suna; Özgüneş, Hilâl

    1981-01-01

    Birçok ülkede süt ve süt ürünleri kişinin diyetinin önemli bir bölümünü oluşturmaktadır. Bu gıda maddelerinin hastalık taşıma potansiyeli yüksek olduğundan, hijyenik kalitelerine özen gösterilmesi gerekir. Bu çalışmada, yurdumuzda büyük ölçüde tüketilen ürünlerden ayran ve yoğurt, hijyenik kaliteleri yönünden incelendi. 9 Haziran-14 Ağustos 1979 tarihleri arasında çeşitli zamanlarda Ankara piyasasından toplanan 50 ayran ve 20 yoğurt örneğinde koliform bakteri sayımı, 40 ayran ve 20 yoğurt ö...

  10. THE EXPECTANCIES OF THE HEALTH SECTOR FROM ACCOUNTING EDUCATION AND THE IMPLEMENTATION OF ANKARA PUBLIC HOSPITALS

    Directory of Open Access Journals (Sweden)

    Seyhan ÇİL KOÇYİĞİT

    2016-01-01

    Full Text Available Health sector requires qualified accounting personnel and demands qualified accounting personnel who knows the sector and who has the vocational knowledge and the ability. Education and training activities designed to meet the expectencies and the requirements of the sector are very important. These requirements can be met by the good quality of accounting education designed by the demands of the health sector. In this research, a survey has been administered to the managers of Ankara public hospitals in order to reveal the expectencies of the health sector from accounting education. The results of the survey show the follwings; accounting education should include practical information, The Uniform Chart Of Accounts should be developed in order to meet the expectencies of the health sector, there should be an internship opportunity at the health sector for accounting students, the content of the accounting courses should be determined by a cooperation between the sector and the academia and the demands of the health sector should be taken into consideration more.

  11. On-going research projects at Ankara Nuclear research center in agriculture and animal science

    International Nuclear Information System (INIS)

    Full text:The research and development activities of Ankara Nuclear Research Center in Agriculture and Animal Science(ANRCAA) are concentrated on the contribution of atomic energy to peace by the use of nuclear and related techniques in food, agriculture and animal science. Nuclear techniques are used in the above fields in two ways: in vitro or in vivo radio tracing the substances and processes of biological importance, and irradiation of biological materials for preservation and quality modification. Research projects are carried out by interdisciplinary studies with well equipped laboratories at the Center. The projects in progress conducted by the Center comprises nuclear-aided researches in soil fertility, plant nutrition, plant protection, improvement of field crops, improvement of horticultural plants and forest trees by mutation breeding, in vitro culture technique with mutagen treatments, use of phosphogypsum in soil amelioration, sterilization of medical supplies, wastewater treatment, animal nutrition, animal health and productivity and accreditation. The on-going projects with the above subjects will be summarized for possible collaborations

  12. The main activities and scientific collaboration possibilities at Ankara Nuclear research and training center

    International Nuclear Information System (INIS)

    Full text: Founded in 1964, Ankara Nuclear Research and Training Center (ANRTC) conducts and facilitates the scientific activities including training (summer practice, MSc and Ph D studies in physics and chemistry, IAEA fellowship programs etc.), research and other studies in nuclear and related fields. As it's a part of main duties, ANRTC has analysis on the variety of samples, and radiation protection services commercially, for radiation workers in state, public and private sectors. Research, development and application projects implemented in this Center have mostly been supported by State Planning Organization (SPO) and Turkish Atomic Energy Authority (TAEA). In addition to the projects there are on going collaborative studies with some national Universities and International Atomic Energy Agency. The main activities carried out in ANRTC can be summarized as: studies on experimental nuclear physics, application of nuclear techniques such as XRF, XRD, Gamma, Alpha, etc. for environmental pollutants, archaeological and geological dating, elemental and crystal structural analyses, studies on the detection of irradiated foodstuff by ESR, development of accident dosimeters to be used in the case of a nuclear or radiological accident, and radiation matter interaction studies. In near future, for young scientists, there will be new collaboration possibilities related to accelerator-based applications, especially the new production methods of radioisotopes and their radiopharmaceuticals by using a cyclotron when our 30 MeVp / 15MeVd cyclotron facility project is underway

  13. Diagnostic Efficacy of All Series of Dynamic Contrast Enhanced Breast MR Images Using Gradient Vector Flow (GVF Segmentation and Novel Border Feature Extraction for Differentiation Between Malignant

    Directory of Open Access Journals (Sweden)

    L. Bahreini

    2010-12-01

    Full Text Available Background/Objective: To discriminate between malignant and benign breast lesions;"nconventionally, the first series of Breast Subtraction Dynamic Contrast-Enhanced Magnetic"nResonance Imaging (BS DCE-MRI images are used for quantitative analysis. In this study, we"ninvestigated whether using all series of these images could provide us with more diagnostic"ninformation."nPatients and Methods: This study included 60 histopathologically proven lesions. The steps of"nthis study were as follows: selecting the regions of interest (ROI, segmentation using Gradient"nVector Flow (GVF snake for the first time, defining new feature sets, using artificial neural network"n(ANN for optimal feature set selection, evaluation using receiver operating characteristic (ROC"nanalysis."nResults: The results showed GVF snake method correctly segmented 95.3% of breast lesion"nborders at the overlap threshold of 0.4. The first classifier which used the optimal feature set"nextracted only from the first series of BS DCE-MRI images achieved an area under the curve"n(AUC of 0.82, specificity of 60% at sensitivity of 81%. The second classifier which used the same"noptimal feature set but was extracted from all five series of these images achieved an AUC of"n0.90, specificity of 79% at sensitivity of 81%."nConclusion: The result of GVF snake segmentation showed that it could make an accurate"nsegmentation in the borders of breast lesions. According to this study, using all five series of BS"nDCE-MRI images could provide us with more diagnostic information about the breast lesion and"ncould improve the performance of breast lesion classifiers in comparison with using the first"nseries alone.

  14. Enhancing spatial resolution of 18F positron imaging with the Timepix detector by classification of primary fired pixels using support vector machine

    International Nuclear Information System (INIS)

    Position-sensitive positron cameras using silicon pixel detectors have been applied for some preclinical and intraoperative clinical applications. However, the spatial resolution of a positron camera is limited by positron multiple scattering in the detector. An incident positron may fire a number of successive pixels on the imaging plane. It is still impossible to capture the primary fired pixel along a particle trajectory by hardware or to perceive the pixel firing sequence by direct observation. Here, we propose a novel data-driven method to improve the spatial resolution by classifying the primary pixels within the detector using support vector machine. A classification model is constructed by learning the features of positron trajectories based on Monte-Carlo simulations using Geant4. Topological and energy features of pixels fired by 18F positrons were considered for the training and classification. After applying the classification model on measurements, the primary fired pixels of the positron tracks in the silicon detector were estimated. The method was tested and assessed for [18F]FDG imaging of an absorbing edge protocol and a leaf sample. The proposed method improved the spatial resolution from 154.6   ±   4.2 µm (energy weighted centroid approximation) to 132.3   ±   3.5 µm in the absorbing edge measurements. For the positron imaging of a leaf sample, the proposed method achieved lower root mean square error relative to phosphor plate imaging, and higher similarity with the reference optical image. The improvements of the preliminary results support further investigation of the proposed algorithm for the enhancement of positron imaging in clinical and preclinical applications. (paper)

  15. Enhancing spatial resolution of 18F positron imaging with the Timepix detector by classification of primary fired pixels using support vector machine

    Science.gov (United States)

    Wang, Qian; Liu, Zhen; Ziegler, Sibylle I.; Shi, Kuangyu

    2015-07-01

    Position-sensitive positron cameras using silicon pixel detectors have been applied for some preclinical and intraoperative clinical applications. However, the spatial resolution of a positron camera is limited by positron multiple scattering in the detector. An incident positron may fire a number of successive pixels on the imaging plane. It is still impossible to capture the primary fired pixel along a particle trajectory by hardware or to perceive the pixel firing sequence by direct observation. Here, we propose a novel data-driven method to improve the spatial resolution by classifying the primary pixels within the detector using support vector machine. A classification model is constructed by learning the features of positron trajectories based on Monte-Carlo simulations using Geant4. Topological and energy features of pixels fired by 18F positrons were considered for the training and classification. After applying the classification model on measurements, the primary fired pixels of the positron tracks in the silicon detector were estimated. The method was tested and assessed for [18F]FDG imaging of an absorbing edge protocol and a leaf sample. The proposed method improved the spatial resolution from 154.6   ±   4.2 µm (energy weighted centroid approximation) to 132.3   ±   3.5 µm in the absorbing edge measurements. For the positron imaging of a leaf sample, the proposed method achieved lower root mean square error relative to phosphor plate imaging, and higher similarity with the reference optical image. The improvements of the preliminary results support further investigation of the proposed algorithm for the enhancement of positron imaging in clinical and preclinical applications.

  16. Erasmus Öğrenci Hareketliliği: Ankara Üniversitesi Değişim Öğrencilerinin Görüşlerine Göre Bazı İyi Uygulamalar

    OpenAIRE

    ASLAN, Berna; Jacobs, Dürdane Bayram

    2012-01-01

    In this case study, opinions of Ankara University Erasmus mobility students were analyzed about their experiences at host Erasmus universities. The aim of the study is to learn the experiences of Ankara University mobility students, find out the reasons of attending Erasmus mobility, the good examples they experienced and discuss whether it changes according to a host country. It is a case study examining the views of Ankara University Erasmus mobility students. A case study research method i...

  17. Transparent 3D Visualization of Archaeological Remains in Roman Site in Ankara-Turkey with Ground Penetrating Radar Method

    Science.gov (United States)

    Kadioglu, S.

    2009-04-01

    Transparent 3D Visualization of Archaeological Remains in Roman Site in Ankara-Turkey with Ground Penetrating Radar Method Selma KADIOGLU Ankara University, Faculty of Engineering, Department of Geophysical Engineering, 06100 Tandogan/ANKARA-TURKEY kadioglu@eng.ankara.edu.tr Anatolia has always been more the point of transit, a bridge between West and East. Anatolia has been a home for ideas moving from all directions. So it is that in the Roman and post-Roman periods the role of Anatolia in general and of Ancyra (the Roman name of Ankara) in particular was of the greatest importance. Now, the visible archaeological remains of Roman period in Ankara are Roman Bath, Gymnasium, the Temple of Augustus of Rome, Street, Theatre, City Defence-Wall. The Caesar Augustus, the first Roman Emperor, conquered Asia Minor in 25 BC. Then a marble temple was built in Ancyra, the administrative capital of province, today the capital of Turkish Republic, Ankara. This monument was consecrated to the Empreror and to the Goddess Rome. This temple is supposed to have built over an earlier temple dedicated to Kybele and Men between 25 -20 BC. After the death of the Augustus in 14AD, a copy of the text of "Res Gestae Divi Augusti" was inscribed on the interior of the pronaos in Latin, whereas a Greek translation is also present on an exterior wall of the cella. In the 5th century, it was converted in to a church by the Byzantines. The aim of this study is to determine old buried archaeological remains in the Augustus temple, Roman Bath and in the governorship agora in Ulus district. These remains were imaged with transparent three dimensional (3D) visualization of the ground penetrating radar (GPR) data. Parallel two dimensional (2D) GPR profile data were acquired in the study areas, and then a 3D data volume were built using parallel 2D GPR data. A simplified amplitude-colour range and appropriate opacity function were constructed and transparent 3D image were obtained to activate buried

  18. A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal Vaccination

    OpenAIRE

    Huang, Xiaoxing; Lu, Bin; Yu, Wenbo; Fang, Qing; Liu, Li; Zhuang, Ke; Shen, Tingting; Wang, Haibo; Tian, Po; Zhang, Linqi; Chen, Zhiwei

    2009-01-01

    Mucosal vaccination offers great advantage for inducing protective immune response to prevent viral transmission and dissemination. Here, we report our findings of a head-to-head comparison of two viral vectors modified vaccinia Ankara (MVA) and a novel replication-competent modified vaccinia Tian Tan (MVTT) for inducing neutralizing antibodies (Nabs) via intramuscular and mucosal vaccinations in mice. MVTT is an attenuated variant of the wild-type VTT, which was historically used as a smallp...

  19. A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination

    OpenAIRE

    Xiaoxing Huang; Bin Lu; Wenbo Yu; Qing Fang; Li Liu; Ke Zhuang; Tingting Shen; Haibo Wang; Po Tian; Linqi Zhang; Zhiwei Chen

    2009-01-01

    Mucosal vaccination offers great advantage for inducing protective immune response to prevent viral transmission and dissemination. Here, we report our findings of a head-to-head comparison of two viral vectors modified vaccinia Ankara (MVA) and a novel replication-competent modified vaccinia Tian Tan (MVTT) for inducing neutralizing antibodies (Nabs) via intramuscular and mucosal vaccinations in mice. MVTT is an attenuated variant of the wild-type VTT, which was historically used as a smallp...

  20. Plasmid Chemokines and Colony-Stimulating Factors Enhance the Immunogenicity of DNA Priming-Viral Vector Boosting Human Immunodeficiency Virus Type 1 Vaccines

    OpenAIRE

    Barouch, Dan H.; McKay, Paul F.; Sumida, Shawn M.; Santra, Sampa; Jackson, Shawn S.; Gorgone, Darci A.; Lifton, Michelle A.; Chakrabarti, Bimal K.; Xu, Ling; Nabel, Gary J.; Letvin, Norman L.

    2003-01-01

    Heterologous “prime-boost” regimens that involve priming with plasmid DNA vaccines and boosting with recombinant viral vectors have been shown to elicit potent virus-specific cytotoxic T-lymphocyte responses. Increasing evidence, however, suggests that the utility of recombinant viral vectors in human populations will be significantly limited by preexisting antivector immunity. Here we demonstrate that the coadministration of plasmid chemokines and colony-stimulating factors with plasmid DNA ...

  1. Vector velocimeter

    DEFF Research Database (Denmark)

    2012-01-01

    generation of a reference beam, a detector system comprising a first detector arrangement arranged in such a way that the signal beam and the reference beam are incident upon the first detector arrangement with the reference beam propagating at an angle relative to a signal beam, and wherein the first......The present invention relates to a compact, reliable and low-cost vector velocimeter for example for determining velocities of particles suspended in a gas or fluid flow, or for determining velocity, displacement, rotation, or vibration of a solid surface, the vector velocimeter comprising a laser...... assembly for emission of a measurement beam for illumination of an object in a measurement volume with coherent light whereby a signal beam emanating from the object in the measurement volume is formed in response to illumination of the object by the measurement beam, a reference beam generator for...

  2. Geochemistry and Geochronology of Oceanic Rock Assemblages in the Izmir-Ankara-Erzincan Suture Zone, Turkey

    Science.gov (United States)

    Sarifakioglu, Ender; Dilek, Yildirim; Sevin, Mustafa

    2013-04-01

    We report here new data from the Izmir-Ankara-Erzincan Suture Zone (IAESZ), which connects the Vardar Suture Zone in the west with the Sevan-Akera Suture Zone in the east. It occurs between the Sakarya Continent and the Anatolide-Tauride ribbon continent in Turkey, and consists mainly of ophiolitic thrust sheets emplaced into a subduction-accretion mélange. The ophiolites include upper mantle peridotites, cumulate to massive gabbros, sheeted doleritic dykes, plagiogranite dykes and stocks, and basalt-chert-radiolarite as in a complete Penrose-type ophiolite pseudostratigraphy. They display a geochemical progression in their magmatic evolution from initially MORB-like to island arc tholeiites (IAT) to boninites, similar to many other Tethyan ophiolites in the eastern Mediterranean region. Boninitic dykes and volcanic rocks have very low TiO2 (0.03-0.50 wt.%), Nb (0.03-1.9 ppm), Y (1,9-10.7ppm) and Zr (4.10-42 ppm) values. IAT-type doleritic dykes and basaltic lavas contain low TiO2 (0.42-1.04 wt.%), Nb (0.90-2.7 wt.%), Y (9.7-33.3 ppm) and Zr (12.7-85 ppm). The TiO2 (0.81-2.60 wt.%), Nb (3.30-4.8 ppm), Y (22.6-63.8 ppm) and Zr (36.01-179.33 ppm) contents of the MORB-like basaltic rocks are higher than those in the IAT and boninitic lavas. The subduction-accretion mélange (Ankara Mélange) in the central part of the IAESZ, includes volcanic mega-blocks derived from seamounts and/or an oceanic plateau that have OIB and P-MORB geochemical characteristics. This subduction-accretion complex also contains blocks of MORB- and/or IAT-like ophiolite fragments within a matrix composed of serpentinite, altered volcanics-volcaniclastics and/or pelitic sedimentary rocks. Pegmatitic gabbros in the ophiolites in the western and eastern IAESZ reveal 40Ar-39Ar hornblende ages of 168.9Ma and 195.7±2.7Ma, respectively. Plagiogranite dykes in the central and eastern parts of the IAESZ are 180 Ma and 179±2 Ma to 180.1±2.4 Ma in age as determined from U-Pb from zircon dates. The

  3. Transcriptional Silencing of Retroviral Vectors

    DEFF Research Database (Denmark)

    Lund, Anders Henrik; Duch, M.; Pedersen, F.S.

    1996-01-01

    Although retroviral vector systems have been found to efficiently transduce a variety of cell types in vitro, the use of vectors based on murine leukemia virus in preclinical models of somatic gene therapy has led to the identification of transcriptional silencing in vivo as an important problem....... Extinction of long-term vector expression has been observed after implantation of transduced hematopoietic cells as well as fibroblasts, myoblasts and hepatocytes. Here we review the influence of vector structure, integration site and cell type on transcriptional silencing. While down-regulation of proviral...... transcription is known from a number of cellular and animal models, major insight has been gained from studies in the germ line and embryonal cells of the mouse. Key elements for the transfer and expression of retroviral vectors, such as the viral transcriptional enhancer and the binding site for the t...

  4. The impact of anti-smoking laws on high school students in Ankara, Turkey

    Directory of Open Access Journals (Sweden)

    Melike Demir

    2015-12-01

    Full Text Available ABSTRACT OBJECTIVE: To determine the factors affecting the smoking habits of high school students, their thoughts about changes resulting from anti-smoking laws, and how they are affected by those laws. METHODS: In this cross-sectional study, 11th-grade students at eight high schools in Ankara, Turkey, were invited to complete a questionnaire. RESULTS: A total of 1,199 students completed the questionnaire satisfactorily. The mean age of the respondents was 17.0 0.6 years; 56.1% were female, of whom 15.3% were smokers; and 43.9% were male, of whom 43.7% were smokers (p < 0.001. The independent risk factors for smoking were male gender, attending a vocational school, having a sibling who smokes, having a friend who smokes, and poor academic performance. Of the respondents, 74.7% were aware of the content of anti-smoking laws; 81.8% approved of the restrictions and fines; and 8.1% had quit smoking because of those laws. According to the respondents, the interventions that were most effective were the (television broadcast of films about the hazards of smoking and the ban on cigarette sales to minors. The prevalence of smoking was highest (31.5% among students attending vocational high schools but lowest (7.5% among those attending medical vocational high schools. Although 57.1% of the smokers were aware of the existence of a smoking cessation helpline, only 3.7% had called, none of whom had made any attempt to quit smoking. CONCLUSIONS: Although most of the students evaluated were aware of the harmful effects of smoking and approved of the anti-smoking laws, only a minority of those who smoked sought professional help to quit.

  5. Data evaluation of Ankara Numune Training and Education Hospital immunofixation electrophoresis

    Directory of Open Access Journals (Sweden)

    Müjgan Ercan

    2013-06-01

    Full Text Available Objective: The immunofixation electrophoresis (IFE is a method used for the diagnosis, monitoring and treatment of monoclonal gammopathies (MG. The monoclonal gammopathies include premalignant or malignant disease such as multiple myeloma, Waldenström’s makroglobulinaemia (WM, plasmacytoma, monoclonal gammopati of undetermined significance (MGUS, plasma cell leukemia and amiloidosis (AL. We aimed to evaluate IFE reports analyzed in Ankara Numune Teaching and Research hospital from January to July 2011.Methods: IFE was studied by Interlab G26 in our laboratory. In this study, all IFE reports examined which analyzed between January and July 2011. The results assessed for frequency and type of MG and also for diagnosis of the disease. Results: A total of 688 patients from January to July 2011 were studied by IFE and 126 (18.3% patients have been identified as MG. There were 72 (57.1% men and 54 (42.9% women in patients with MG. Distribution of isotypes were IgG kappa 41.3%, IgG lambda 35.6%, IgA kappa 11.5%, IgA lambda 5.8%, IgM kappa 3.8% and IgM lambda 1.9%. There were MM (65.9%, WM (0.07% and MGUS (33% in patients with MG.Conclusion: IgG kappa was the most common type of MG and MM was the most common disease in these patients. MG detection rate was 18% in patients requested IFE test. The decreased rate has shown that at first serum protein electrophoresis must studied and then IFE test must be performed in patients who have an uncertainty of MG. J Clin Exp Invest 2013; 4 (2:148-152Key words: Monoclonal gammopathies, immunofixation electrophoresis, multiple myeloma

  6. The Experiences of Violence and Occupational Health Risks of Sex Workers Working in Brothels in Ankara

    Directory of Open Access Journals (Sweden)

    Yaşar Bilge

    2012-06-01

    Full Text Available Objective: The aim of this study was to reveal and discuss occupational health risks, violence against sex workers working in brothels and their working conditions in Ankara. Materials and Methods: The study included 138 sex workers. Data were collected at face to face interviews with a questionnaire composed of 40 questions about socio-demographic features, familial characteristics, reasons for becoming a sex worker, experiences of violence and occupational health risks. Results: Twenty-two point five percent of the women were aged 21-30 years and 39.9% were aged 31-40 years. The mean time of education was 5.9±3.5 (0-14 years. Forty-eight point five percent of the women were exposed to physical abuse and 13% of the women had been exposed to sexual abuse in their childhood. Fifty-five point eight percent of the women reported that their clients always used condoms, but 97.1% of the women noted that their clients insisted on not using a condom. Fourteen point five percent and 70.3% of the women were exposed to physical and verbal violence respectively from their clients. Ten point one percent of the women suffered sexual assault while working. Conclusion: Sex workers, like other people, should have human rights, all types of violence that they face should be eliminated and the social conditions they are exposed to should be improved. Sexually transmitted diseases, the most important health risk of sex workers, should be considered as occupational diseases in the new regulations.

  7. Ankara Üniversitesi Sağlık Bilimleri Fakültesi Kütüphaneleri’nde Kataloglamada Uyumun Ölçülmesi / Measuring Cataloging Consistency in Health Sciences Faculty Libraries at Ankara University

    Directory of Open Access Journals (Sweden)

    Doğan Atılgan

    2006-04-01

    Full Text Available The purpose of this study was to examine the cataloging consistency between health sciences faculty libraries at Ankara University. Online catalogs at four faculty libraries are used to detect differencies in MARC records. Access points included AACR2, main entry, title statement and area of responsibility, edition statement, publication, distribution (etc., physical description area, series area, and added entries are compared. Findings showed certain amount of inconsistency among the access points analysed. Highest numbers of inconsistencies among all libraries were found in the title and responsibility statement fields.

  8. Evaluation of a quasi-fractal dimension to enhance breast cancer detection in X-ray mammograms using support vector machine

    International Nuclear Information System (INIS)

    We previously introduced a quasi-fractal dimension (Q-FD) to enhance breast cancer detection in X-ray mammography. In the present study, we evaluated the usefulness of this image feature for differentiating between benign and malignant masses using a support vector machine (SVM) with various kernels. The kernel computes the inner product of the functions that embed the data into a feature space where the nonlinear pattern appears linear. Q-FD was calculated using the method previously reported from the database of X-ray mammograms produced by the Japan Society of Radiological Technology. In addition to Q-FD, the image features such as curvature (C) and eccentricity (E) were extracted. The conventional fractal dimension (C-FD) was also calculated using the box-counting method. First, we investigated the SVM performance in terms of accuracy, sensitivity and specificity in the task of differentiating between benign and malignant masses by taking 5 parameters (C, E, C-FD, Q-FD and age) as input features in SVM. When using the linear kernel, the best accuracy was obtained at a regularization parameter of 50. For the polynomial and radial basis function (RBF) kernels, the best accuracy was obtained when the degree of polynomial and the width of RBF were 1 and 1, respectively. The accuracies were 0.746±0.089, 0.731±0.095 and 0.734±0.086 for the linear, polynomial and RBF kernels, respectively, when using C, E, C-FD and age as input features in the SVM. When Q-FD was added to the above input features, the accuracies were significantly improved to 0.957±0.045, 0.950±0.045 and 0.949±0.052 for the linear, polynomial and RBF kernels, respectively. These results suggest that Q-FD is effective for discriminating between benign and malignant masses and SVM is highly recommended as a classifier for its simple utilization and good performance, especially when the training set size is small. (author)

  9. Production of recombinant AAV vectors encoding insulin-like growth factor I is enhanced by interaction among AAV rep regulatory sequences

    Directory of Open Access Journals (Sweden)

    Dilley Robert

    2009-01-01

    Full Text Available Abstract Background Adeno-associated virus (AAV vectors are promising tools for gene therapy. Currently, their potential is limited by difficulties in producing high vector yields with which to generate transgene protein product. AAV vector production depends in part upon the replication (Rep proteins required for viral replication. We tested the hypothesis that mutations in the start codon and upstream regulatory elements of Rep78/68 in AAV helper plasmids can regulate recombinant AAV (rAAV vector production. We further tested whether the resulting rAAV vector preparation augments the production of the potentially therapeutic transgene, insulin-like growth factor I (IGF-I. Results We constructed a series of AAV helper plasmids containing different Rep78/68 start codon in combination with different gene regulatory sequences. rAAV vectors carrying the human IGF-I gene were prepared with these vectors and the vector preparations used to transduce HT1080 target cells. We found that the substitution of ATG by ACG in the Rep78/68 start codon in an AAV helper plasmid (pAAV-RC eliminated Rep78/68 translation, rAAV and IGF-I production. Replacement of the heterologous sequence upstream of Rep78/68 in pAAV-RC with the AAV2 endogenous p5 promoter restored translational activity to the ACG mutant, and restored rAAV and IGF-I production. Insertion of the AAV2 p19 promoter sequence into pAAV-RC in front of the heterologous sequence also enabled ACG to function as a start codon for Rep78/68 translation. The data further indicate that the function of the AAV helper construct (pAAV-RC, that is in current widespread use for rAAV production, may be improved by replacement of its AAV2 unrelated heterologous sequence with the native AAV2 p5 promoter. Conclusion Taken together, the data demonstrate an interplay between the start codon and upstream regulatory sequences in the regulation of Rep78/68 and indicate that selective mutations in Rep78/68 regulatory elements

  10. Indoor radon concentrations and radon doses at three districts of Ankara, Turkey and raising public awareness on the issue

    International Nuclear Information System (INIS)

    Indoor radon concentrations at METU, CIGDEM and DOSTLAR in Ankara were measured using electrets. The statistical analysis of the data indicated a lognormal distribution of radon concentrations, with no significant difference between CIGDEM and DOSTLAR with geometric means of GM = 87.5 and 54.5 Bq m-3, respectively. Radon concentrations did not change seasonally at CIGDEM which contain modern buildings, but at the slum district DOSTLAR, with poor insulation of houses a seasonal variation was observed. Annual effective radon doses were estimated (0.4-8.4 mSv). Public awareness about indoor radon was raised. (author)

  11. Evaluation of the children on trial in the Ankara 1st children s High Criminal Court for peer abuse

    OpenAIRE

    ŞENGÜL, Hasan Atakan; CANTÜRK, Nergis; Cantürk, Gürol; Dağalp, Rukiye

    2012-01-01

    Aim: Children performing acts defined as criminal law are the children who are dragged into crime When the victim of the identified actions are children both the number of children who need protection and who are dragged into crime increases and the victim of both sides in the incident become children Material and Method: The case files and cartons of decisions of 188 events sentenced in the Ankara 1st Children rsquo;s High Criminal Court for 4 year period between 2007 2010 in which victims a...

  12. 4-1BBL enhances CD8+ T cell responses induced by vectored vaccines in mice but fails to improve immunogenicity in rhesus macaques.

    OpenAIRE

    Spencer, AJ; Furze, J; Honeycutt, JD; Calvert, A; Saurya, S; Colloca, S; Wyllie, DH; Gilbert, SC; Bregu, M; Cottingham, MG; Hill, AV

    2014-01-01

    T cells play a central role in the immune response to many of the world's major infectious diseases. In this study we investigated the tumour necrosis factor receptor superfamily costimulatory molecule, 4-1BBL (CD137L, TNFSF9), for its ability to increase T cell immunogenicity induced by a variety of recombinant vectored vaccines. To efficiently test this hypothesis, we assessed a number of promoters and developed a stable bi-cistronic vector expressing both the antigen and adjuvant. Co-expre...

  13. Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors

    Directory of Open Access Journals (Sweden)

    Wei Wen

    2016-06-01

    Full Text Available We previously reported the generation of integration-free induced pluripotent stem cells from adult peripheral blood (PB with an improved episomal vector (EV system, which uses the spleen focus-forming virus U3 promoter and an extra factor BCL-XL (B. Here we show an ∼100-fold increase in efficiency by optimizing the vector combination. The two most critical factors are: (1 equimolar expression of OCT4 (O and SOX2 (S, by using a 2A linker; (2 a higher and gradual increase in the MYC (M to KLF4 (K ratio during the course of reprogramming, by using two individual vectors to express M and K instead of one. The combination of EV plasmids (OS + M + K + B is comparable with Sendai virus in reprogramming efficiency but at a fraction of the cost. The generated iPSCs are indistinguishable from those from our previous approach in pluripotency and phenotype. This improvement lays the foundation for broad applications of episomal vectors in PB reprogramming.

  14. EVALUATION OF THE ENVIRONMENTAL CONSCIOUSNESS OF THE STUDENTS IN A MEDICAL FACULTY IN ANKARA

    Directory of Open Access Journals (Sweden)

    Songul VAIZOÐLU

    2005-08-01

    Full Text Available Objectives: The reseach is conducted to evaluate the environmental consciousness of the students in a medical faculty in Ankara. Materials and Methods: Of the 412 students, 342 (83.0% participated this cross-sectional study. Data were collected in August 2000 with ?Environmental Consciousness Research Form?, the questionnaire prepared by the researchers and analysed using EPI INFO 6.0, a statistical package programme. Results: Mean age of the study group was 23.71 and 54.7% were male. Most of the students (74.4% reported that they would go to school/work by bycle, bus or on foot, and 87.1 percent of them told they would prefer train. Of the participants, 72.3% think environmental problems are not the issues only governments would care about. While most of them (81.8% reported that they would give up buying the products harmful to the environment, only 18.8% told they would want to deliver brochures about environment to each house. Nearly half of the students reported that they wouldn?t spend their money for the solution of environmental problems. Most of the students reported that they didn?t admit to any official institution to get information on environmental pollution (90.3%, never attended a meeting on environment (85.6% and never subscribed to a publication about the environment (91.4%. The students knew the products containing mercury, the substances which do not dissepear in the ocean and about the ozone layer depletion. Environmental consciousness scores are calculated by grading the questions about environmental consciousness. Mean score was 27.47. Nearly half of the students (53.2% had a score over 28. Students reported that deforestation (10.1%, air pollution (8.0%, population explosion (7.8%, nuclear weapons (7.3% and industrial wastes (7.1% would be the most important problems in 21. century. Conclusion: Complementing the lack of knowledge determined in the study by planning educational programmes, considering the environmental

  15. BURNOUT STATUS OF EMPLOYEES WORKING AT ANKARA FACTORIES AND SECOND REGIONAL DIRECTORATE OF TURKISH REPUBLIC STATE RAILWAY

    Directory of Open Access Journals (Sweden)

    Isil Irem BUDAKOÐLU

    2006-10-01

    Full Text Available Burnout is a person’s separation from the original mean of and the aim of his/her job. In this study we aimed to determine the burnout status of employees who were working at the factories and regional directorate of State Railways in Ankara. The study was applied at the wagon-locomotive care and repair, Ankara railway factories and 2nd Regional Directorate with an enrollment of 560 workers, on the date of March 2005. Maslach Burnout Inventory was used in order to determine the burnout status of workers. Emotional exhaustion scores of women, 39 years and younger workers, college or higher school graduates, white collar workers and chiefs are statistically higher than their counterparts (p<0.05. Workers who were younger than 39 years and were using alcohol had a statistically higher depersonalization scores than 40 years and older ones, and non alcohol users (p<0.05. However, the personal accomplishment score of high school and lower school graduates was statistically lower than college or higher school graduates (p<0.05. In conclusion, burnout status influences from demographic characteristics of workers, occupational group, title, monthly income and personal risk factors. [TAF Prev Med Bull 2006; 5(5.000: 317-325

  16. Introduction of the Six Major Genomic Deletions of Modified Vaccinia Virus Ankara (MVA) into the Parental Vaccinia Virus Is Not Sufficient To Reproduce an MVA-Like Phenotype in Cell Culture and in Mice▿

    Science.gov (United States)

    Meisinger-Henschel, Christine; Späth, Michaela; Lukassen, Susanne; Wolferstätter, Michael; Kachelriess, Heike; Baur, Karen; Dirmeier, Ulrike; Wagner, Markus; Chaplin, Paul; Suter, Mark; Hausmann, Jürgen

    2010-01-01

    Modified vaccinia virus Ankara (MVA) has a highly restricted host range in cell culture and is apathogenic in vivo. MVA was derived from the parental chorioallantois vaccinia virus Ankara (CVA) by more than 570 passages in chicken embryo fibroblast (CEF) cells. During CEF cell passaging, six major deletions comprising 24,668 nucleotides occurred in the CVA genome. We have cloned both the MVA and the parental CVA genome as bacterial artificial chromosomes (BACs) and have sequentially introduced the six major MVA deletions into the cloned CVA genome. Reconstituted mutant CVA viruses containing up to six major MVA deletions showed no detectable replication restriction in 12 of 14 mammalian cell lines tested; the exceptions were rabbit cell lines RK13 and SIRC. In mice, CVA mutants with up to three deletions showed slightly enhanced virulence, suggesting that gene deletion in replicating vaccinia virus (VACV) can result in gain of fitness in vivo. CVA mutants containing five or all six deletions were still pathogenic, with a moderate degree of attenuation. Deletion V was mainly responsible for the attenuated phenotype of these mutants. In conclusion, loss or truncation of all 31 open reading frames in the six major deletions is not sufficient to reproduce the specific MVA phenotype of strong attenuation and highly restricted host range. Mutations in viral genes outside or in association with the six major deletions appear to contribute significantly to this phenotype. Host range restriction and avirulence of MVA are most likely a cooperative effect of gene deletions and mutations involving the major deletions. PMID:20668072

  17. Introduction of the six major genomic deletions of modified vaccinia virus Ankara (MVA) into the parental vaccinia virus is not sufficient to reproduce an MVA-like phenotype in cell culture and in mice.

    Science.gov (United States)

    Meisinger-Henschel, Christine; Späth, Michaela; Lukassen, Susanne; Wolferstätter, Michael; Kachelriess, Heike; Baur, Karen; Dirmeier, Ulrike; Wagner, Markus; Chaplin, Paul; Suter, Mark; Hausmann, Jürgen

    2010-10-01

    Modified vaccinia virus Ankara (MVA) has a highly restricted host range in cell culture and is apathogenic in vivo. MVA was derived from the parental chorioallantois vaccinia virus Ankara (CVA) by more than 570 passages in chicken embryo fibroblast (CEF) cells. During CEF cell passaging, six major deletions comprising 24,668 nucleotides occurred in the CVA genome. We have cloned both the MVA and the parental CVA genome as bacterial artificial chromosomes (BACs) and have sequentially introduced the six major MVA deletions into the cloned CVA genome. Reconstituted mutant CVA viruses containing up to six major MVA deletions showed no detectable replication restriction in 12 of 14 mammalian cell lines tested; the exceptions were rabbit cell lines RK13 and SIRC. In mice, CVA mutants with up to three deletions showed slightly enhanced virulence, suggesting that gene deletion in replicating vaccinia virus (VACV) can result in gain of fitness in vivo. CVA mutants containing five or all six deletions were still pathogenic, with a moderate degree of attenuation. Deletion V was mainly responsible for the attenuated phenotype of these mutants. In conclusion, loss or truncation of all 31 open reading frames in the six major deletions is not sufficient to reproduce the specific MVA phenotype of strong attenuation and highly restricted host range. Mutations in viral genes outside or in association with the six major deletions appear to contribute significantly to this phenotype. Host range restriction and avirulence of MVA are most likely a cooperative effect of gene deletions and mutations involving the major deletions. PMID:20668072

  18. Combinatorial Incorporation of Enhancer Blocking Components of the Chicken β-Globin 5′HS4 and Human T-Cell Receptor α/δ BEAD-1 Insulators in Self-Inactivating Retroviral Vectors Reduces their Genotoxic Potential

    OpenAIRE

    Ramezani, Ali; Hawley, Teresa S.; Hawley, Robert G.

    2008-01-01

    Insertional mutagenesis by retroviral vectors has emerged as a serious impediment to the widespread application of hematopoietic stem cell gene transfer for the treatment of hematologic diseases. Here we report the development of a 77-bp element, FII/BEAD-A (FB), which contains the minimal enhancer blocking components of the chicken β-globin 5′HS4 insulator and a homologous region from the human T-cell receptor α/δ BEAD-1 insulator. With a new flow cytometry-based assay, we show that the FB e...

  19. Intranasal Mucosal Boosting with an Adenovirus-Vectored Vaccine Markedly Enhances the Protection of BCG-Primed Guinea Pigs against Pulmonary Tuberculosis

    OpenAIRE

    Xing, Zhou; McFarland, Christine T.; Sallenave, Jean-Michel; Izzo, Angelo; Wang, Jun; McMURRAY, David N.

    2009-01-01

    Background Recombinant adenovirus-vectored (Ad) tuberculosis (TB) vaccine platform has demonstrated great potential to be used either as a stand-alone or a boost vaccine in murine models. However, Ad TB vaccine remains to be evaluated in a more relevant and sensitive guinea pig model of pulmonary TB. Many vaccine candidates shown to be effective in murine models have subsequently failed to pass the test in guinea pig models. Methods and Findings Specific pathogen-free guinea pigs were immuniz...

  20. [Brucellosis, tularemia and borreliosis isolated from wild animals captured in Ankara, Konya, Urfa and Nevsehir provinces in Turkey].

    Science.gov (United States)

    Ozsan, K; Fazh, A; Aktan, M; Beyoğlu, K

    1976-10-01

    621 citellus, 41 Mus musculus, 35 microtus, 442 meriones, 70 Rattus rattus, 56 turtle, 89 hare, 1 hamster, 1 hedgehog and 1 sea snake, altogether 1379 wild animals were captured in Ankara, Konya, Urfa and Nevşehir. Neither Brucella or Francisella tularansis could be isolated nor borrelia could be seen. 1/40-1/80 agglutination titers obtained in 3 out of 134 sera taken from citellus, in 3 out of 264 sera taken from guinea pigs which were inoculated with spleen, liver and kidney suspensions of wild animals. 1/40-1/80 agglutination titers obtained against brucella antigen in 3 out of 125 sera taken from citellus. No significant agglutination titers could be obtained in 35 sera taken from guinea pigs which were inoculated with the organ suspensions of wild animals. In blood samples of 2 citellus few trypanosoma were detected. PMID:979704

  1. Jurassic–Paleogene intraoceanic magmatic evolution of the Ankara Mélange, north-central Anatolia, Turkey

    OpenAIRE

    E. Sarifakioglu; Dilek, Y.; M. Sevin

    2014-01-01

    Oceanic rocks in the Ankara Mélange along the Izmir–Ankara–Erzincan suture zone (IAESZ) in north-central Anatolia include locally coherent ophiolite complexes (~ 179 Ma and ~ 80 Ma), seamount or oceanic plateau volcanic units with pelagic and reefal limestones (96.6 ± 1.8 Ma), metamorphic rocks with ages of 256.9 ± 8.0 Ma, 187.4 ± 3.7 Ma, 158.4 ± 4.2 Ma, and 83.5 ± 1.2 Ma indicating northern Tethys during the late Paleozoic through Cretaceous, and subalkaline to alkaline volcanic and plutonic...

  2. A report on the study of algorithms to enhance Vector computer performance for the discretized one-dimensional time-dependent heat conduction equation: EPIC research, Phase 1

    Energy Technology Data Exchange (ETDEWEB)

    Majumdar, A.; Makowitz, H.

    1987-10-01

    With the development of modern vector/parallel supercomputers and their lower performance clones it has become possible to increase computational performance by several orders of magnitude when comparing to the previous generation of scalar computers. These performance gains are not observed when production versions of current thermal-hydraulic codes are implemented on modern supercomputers. It is our belief that this is due in part to the inappropriateness of using old thermal-hydraulic algorithms with these new computer architectures. We believe that a new generation of algorithms needs to be developed for thermal-hydraulics simulation that is optimized for vector/parallel architectures, and not the scalar computers of the previous generation. We have begun a study that will investigate several approaches for designing such optimal algorithms. These approaches are based on the following concepts: minimize recursion; utilize predictor-corrector iterative methods; maximize the convergence rate of iterative methods used; use physical approximations as well as numerical means to accelerate convergence; utilize explicit methods (i.e., marching) where stability will permit. We call this approach the ''EPIC'' methodology (i.e., Explicit Predictor Iterative Corrector methods). Utilizing the above ideas, we have begun our work by investigating the one-dimensional transient heat conduction equation. We have developed several algorithms based on variations of the Hopscotch concept, which we discuss in the body of this report. 14 refs.

  3. Axisymmetric Coanda-Assisted Vectoring

    OpenAIRE

    Allen, Dustin S

    2008-01-01

    An examination of parameters affecting the control of a jet vectoring technique used in the Coanda-assisted Spray Manipulation (CSM) is presented. The CSM makes use of an enhanced Coanda effect on axisymmetric geometries through the interaction of a high volume primary jet flowing through the center of a collar and a secondary high-momentum jet parallel to the first and adjacent to the convex collar. The control jet attaches to the convex wall and vectors according to known Coanda effect prin...

  4. Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8+ T Cell Epitopes

    Directory of Open Access Journals (Sweden)

    Pablo D. Becker

    2014-07-01

    Full Text Available Viral vectors are promising tools for vaccination strategies and immunotherapies. However, CD8+ T cell responses against pathogen-derived epitopes are usually limited to dominant epitopes and antibody responses to recombinant encoded antigens (Ags are mostly weak. We have previously demonstrated that the timing of viral Ag expression in infected professional Ag-presenting cells strongly shapes the epitope immunodominance hierarchy. T cells recognizing determinants derived from late viral proteins have a clear disadvantage to proliferate during secondary responses. In this work we evaluate the effect of overexpressing the recombinant Ag using the modified vaccinia virus early/late promoter H5 (mPH5. Although the Ag-expression from the natural promoter 7.5 (P7.5 and the mPH5 seemed similar, detailed analysis showed that mPH5 not only induces higher expression levels than P7.5 during early phase of infection, but also Ag turnover is enhanced. The strong overexpression during the early phase leads to broader CD8 T cell responses, while preserving the priming efficiency of stable Ags. Moreover, the increase in Ag-secretion favors the induction of strong antibody responses. Our findings provide the rationale to develop new strategies for fine-tuning the responses elicited by recombinant modified vaccinia virus Ankara by using selected promoters to improve the performance of this viral vector.

  5. Rotations with Rodrigues' Vector

    Science.gov (United States)

    Pina, E.

    2011-01-01

    The rotational dynamics was studied from the point of view of Rodrigues' vector. This vector is defined here by its connection with other forms of parametrization of the rotation matrix. The rotation matrix was expressed in terms of this vector. The angular velocity was computed using the components of Rodrigues' vector as coordinates. It appears…

  6. Deletion of A44L, A46R and C12L Vaccinia Virus Genes from the MVA Genome Improved the Vector Immunogenicity by Modifying the Innate Immune Response Generating Enhanced and Optimized Specific T-Cell Responses

    Science.gov (United States)

    Holgado, María Pía; Falivene, Juliana; Maeto, Cynthia; Amigo, Micaela; Pascutti, María Fernanda; Vecchione, María Belén; Bruttomesso, Andrea; Calamante, Gabriela; del Médico-Zajac, María Paula; Gherardi, María Magdalena

    2016-01-01

    MVA is an attenuated vector that still retains immunomodulatory genes. We have previously reported its optimization after deleting the C12L gene, coding for the IL-18 binding-protein. Here, we analyzed the immunogenicity of MVA vectors harboring the simultaneous deletion of A44L, related to steroid synthesis and A46R, a TLR-signaling inhibitor (MVAΔA44L-A46R); or also including a deletion of C12L (MVAΔC12L/ΔA44L-A46R). The absence of biological activities of the deleted genes in the MVA vectors was demonstrated. Adaptive T-cell responses against VACV epitopes, evaluated in spleen and draining lymph-nodes of C57Bl/6 mice at acute/memory phases, were of higher magnitude in those animals that received deleted MVAs compared to MVAwt. MVAΔC12L/ΔA44L-A46R generated cellular specific memory responses of higher quality characterized by bifunctionality (CD107a/b+/IFN-γ+) and proliferation capacity. Deletion of selected genes from MVA generated innate immune responses with higher levels of determining cytokines related to T-cell response generation, such as IL-12, IFN-γ, as well as IL-1β and IFN-β. This study describes for the first time that simultaneous deletion of the A44L, A46R and C12L genes from MVA improved its immunogenicity by enhancing the host adaptive and innate immune responses, suggesting that this approach comprises an appropriate strategy to increase the MVA vaccine potential. PMID:27223301

  7. Two Layer Vector Quantization of Images

    Directory of Open Access Journals (Sweden)

    V. Michalcin

    2001-06-01

    Full Text Available This paper deals with spatial scaleable vector quantization ofimages by using two layers. At the base layer the small dimensionalfull search vector quantization of an image of block means is carriedout. After subtracting it from the input image at the enhancement layerthe difference of full spatial resolution is quantized by largedimensional weighted pyramid vector quantizer in transform domain.Experimental results demonstrate acceptable quality of the downscaledimage from the output of base layer at very low bit rate andpossibility of next increasing its quality by the upscaled differenceimage from the output of enhancement layer.

  8. Kochen-Specker vectors

    International Nuclear Information System (INIS)

    We give a constructive and exhaustive definition of Kochen-Specker (KS) vectors in a Hilbert space of any dimension as well as of all the remaining vectors of the space. KS vectors are elements of any set of orthonormal states, i.e., vectors in an n-dimensional Hilbert space, Hn, n≥3, to which it is impossible to assign 1s and 0s in such a way that no two mutually orthogonal vectors from the set are both assigned 1 and that not all mutually orthogonal vectors are assigned 0. Our constructive definition of such KS vectors is based on algorithms that generate MMP diagrams corresponding to blocks of orthogonal vectors in Rn, on algorithms that single out those diagrams on which algebraic (0)-(1) states cannot be defined, and on algorithms that solve nonlinear equations describing the orthogonalities of the vectors by means of statistically polynomially complex interval analysis and self-teaching programs. The algorithms are limited neither by the number of dimensions nor by the number of vectors. To demonstrate the power of the algorithms, all four-dimensional KS vector systems containing up to 24 vectors were generated and described, all three-dimensional vector systems containing up to 30 vectors were scanned, and several general properties of KS vectors were found

  9. Wolbachia strain wPip yields a pattern of cytoplasmic incompatibility enhancing a Wolbachia-based suppression strategy against the disease vector Aedes albopictus

    Directory of Open Access Journals (Sweden)

    Calvitti Maurizio

    2012-11-01

    Full Text Available Abstract Background Cytoplasmic incompatibility (CI is induced in nature by Wolbachia bacteria, resulting in conditional male sterility. Previous research demonstrated that the two Wolbachia strains (wAlbA and wAlbB that naturally co-infect the disease vector mosquito Aedes albopictus (Asian tiger mosquito can be replaced with the wPip Wolbachia strain from Culex pipiens. Since Wolbachia-based vector control strategies depend upon the strength and consistency of CI, a greater understanding is needed on the CI relationships between wPip, wAlbA and wAlbB Wolbachia in Ae. albopictus. Methods This work consisted of a collaborative series of crosses carried out in Italy and in US to study the CI relationships between the “wPip” infected Ae. albopictus strain (ARwP and the superinfected SR strain. The Ae. albopictus strains used in Italian tests are the wPip infected ARwP strain (ARwPIT, the superinfected SR strain and the aposymbiotic AR strain. To understand the observed pattern of CI, crossing experiments carried out in USA focused on the study of the CI relationships between ARwP (ARwPUS and artificially-generated single infected lines, in specific HTA and HTB, harbouring only wAlbA and wAlbB Wolbachia respectively. Results The paper reports an unusual pattern of CI observed in crossing experiments between ARwP and SR lines. Specifically, ARwP males are able to induce full sterility in wild type females throughout most of their lifetime, while crosses between SR males and ARwP females become partially fertile with male aging. We demonstrated that the observed decrease in CI penetrance with SR male age, is related to the previously described decrease in Wolbachia density, in particular of the wAlbA strain, occurring in aged superinfected males. Conclusions The results here reported support the use of the ARwP Ae. albopictus line as source of “ready-made sterile males”, as an alternative to gamma radiation sterilized males, for autocidal

  10. Dendritic cell-based vaccination with lentiviral vectors encoding ubiquitinated hepatitis B core antigen enhances hepatitis B virus-specific immune responses in vivo.

    Science.gov (United States)

    Dai, Shenglan; Zhuo, Meng; Song, Linlin; Chen, Xiaohua; Yu, Yongsheng; Tang, Zhenghao; Zang, Guoqing

    2015-11-01

    The activity of hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) plays a predominant role in the clearance of HBV. Dendritic cells (DCs) are key antigen-presenting cells and play an important role in the initiation of immune responses. We previously verified that lentiviral vector encoding ubiquitinated hepatitis B core antigen (LV-Ub-HBcAg) effectively transduced DCs to induce maturation, and the mature DCs efficiently induced T cell polarization to Th1 and generated HBcAg-specific CTLs ex vivo. In this study, HBV-specific immune responses of LV-Ub-HBcAg in BALB/c mice (H-2Kd) were evaluated. It was shown that direct injection of LV-Ub-HBcAg increased the production of cytokines IL-2 and IFN-γ, elicited strong antibody responses, and remarkably generated a high percentage of IFN-γ+CD8+ T cells with HBV-specific CTL responses in BALB/c mice. In addition, direct injection of LV-Ub-HBcAg induced potent anti-HBV immune responses, similar to those elicited by in vitro-transduced DCs. In conclusion, the DC-based therapeutic vaccine LV-Ub-HBcAg elicited specific antibody immune responses and induced robust specific CTL activity in vivo. PMID:26373843

  11. Introduction of the Six Major Genomic Deletions of Modified Vaccinia Virus Ankara (MVA) into the Parental Vaccinia Virus Is Not Sufficient To Reproduce an MVA-Like Phenotype in Cell Culture and in Mice▿

    OpenAIRE

    Meisinger-Henschel, Christine; Späth, Michaela; Lukassen, Susanne; Wolferstätter, Michael; Kachelriess, Heike; Baur, Karen; Dirmeier, Ulrike; Wagner, Markus; Chaplin, Paul; Suter, Mark; Hausmann, Jürgen

    2010-01-01

    Modified vaccinia virus Ankara (MVA) has a highly restricted host range in cell culture and is apathogenic in vivo. MVA was derived from the parental chorioallantois vaccinia virus Ankara (CVA) by more than 570 passages in chicken embryo fibroblast (CEF) cells. During CEF cell passaging, six major deletions comprising 24,668 nucleotides occurred in the CVA genome. We have cloned both the MVA and the parental CVA genome as bacterial artificial chromosomes (BACs) and have sequentially introduce...

  12. Ankara Üniversitesi Uzaktan Eğitim Programına Katılan Öğrencilerin Akademik Başarılarını Yordayan Faktörler

    OpenAIRE

    Selma Şenel; Ömer Kutlu

    2015-01-01

    The aim of this study was to determine the factors predicting academic achievement of Ankara University Distance Education students. The study group of the research consists of 302 first grade students from Ankara University Distance Education Center (ANKUZEM) 2010-2011 associate degree programs. Data were formed in four groups respectively “individual characteristics”, “characteristics related with family and working environment”, “characteristics related with usage of informatio...

  13. [Tuberculosis Laboratory Surveillance Network (TuLSA) study group. The first step for national tuberculosis laboratory surveillance: Ankara, 2011].

    Science.gov (United States)

    Sezen, Figen; Albayrak, Nurhan; Özkara, Şeref; Karagöz, Alper; Alp, Alpaslan; Duyar Ağca, Filiz; İnan Süer, Asiye; Müderris, Tuba; Ceyhan, İsmail; Durmaz, Rıza; Ertek, Mustafa

    2015-04-01

    The most effective method for monitoring country-level drug resistance frequency and to implement the necessary control measures is the establishment of a laboratory-based surveillance system. The aim of this study was to summarize the follow up trend of the drug-resistant tuberculosis (TB) cases, determine the load of resistance and evaluate the capacities of laboratories depending on laboratory quality assurance system for the installation work of National Tuberculosis Laboratory Surveillance Network (TuLSA) which has started in Ankara in 2011. TuLSA studies was carried out under the coordination of National Tuberculosis Reference Laboratory (NRL) with the participation of TB laboratories and dispensaries. Specimens of TB patients, reported from health institutions, were followed in TB laboratories, and the epidemiological information was collected from the dispensaries. One isolate per patient with the drug susceptibility test (DST) results were sent to NRL from TB laboratories and in NRL the isolates were rechecked with the genotypical (MTBDRplus, Hain Lifescience, Germany) and phenotypical (MGIT 960, BD, USA) DST methods. Molecular epidemiological analysis were also performed by spoligotyping and MIRU/VNTR. Second-line DST was applied to the isolates resistant to rifampin. A total of 1276 patients were reported between January 1st to December 31th 2011, and 335 cases were defined as "pulmonary TB from Ankara province". The mean age of those patients was 43.4 ± 20 years, and 67.5% were male. Three hundred seventeen (94.6%) patients were identified as new cases. The average sample number obtained from pulmonary TB cases was 3.26 ± 2.88, and 229 (68.3%) of them was culture positive. DST was applied to all culture positive isolates; 90.4% (207/229) of cases were susceptible to the five drugs tested (ethambutol, isoniazid, pyrazinamide, rifampicin, streptomycin). Eight (3.5%) of the isolates were multidrug-resistant (MDR-TB), while no extensively drug

  14. The Use of Alternate Ligno-cellulosic Raw Materials Banana (Musa sapientum Ankara (Calotropis procera and Pineapple (Ananas comosus in Handmade Paper & their Blending with Waste Paper.

    Directory of Open Access Journals (Sweden)

    Atul Kumar

    2013-09-01

    Full Text Available The studies were made to established suitability of lingo-cellulosic raw materials namely leaf fibreBanana (Musa Sapientum, bast fibre Ankara (Calotropis Procera, & leaf fibre Pineapple (Ananas Comosus for making pulps for handmade paper industry. This should help in providing a cost effective, good quality cellulosic raw material as an alternate to cost prohibitive traditionally used cotton hosiery waste traditionally used for manufacturing good quality handmade paper & it’s products. This will help in improving the cost economics & competitiveness of the Indian paper industry in the global market besides addressing the problems of environment & global warming. The aim of the research was to study the extraction, morphology, chemical composition and pulping of these fibres and relate these properties to the composite properties obtained with these fibres as reinforcement with short fibres viz. waste paper. For the pulp production to be feasible it is essential to use suitable pulping methods, which maximize the yield of pulp and introduce as low damage as possible to the fibres. The different pulping methods were applied to these fibre to get optimized strength properties papers. The Studies thus carried out provide useful information about the nature of these raw materials, suitable pulping & bleaching process to produce an eco-friendly handmade paper and converted products. The research work provides a good quality cost effective lingo-cellulosic raw material for handmade paper industries with a possibility of replacement of the expensive and traditionally used cotton hosiery waste.The paper thus produced using environmental friendly pulping and bleaching process is characterized for its strength properties like tensile, tear, bursting, folding endurance and other parameters. The effluents generated from pulping and bleaching of above ligno-cellulosic waste materials were characterized for various pollution parameters like Residual Alkali

  15. Concise vector analysis

    CERN Document Server

    Eliezer, C J; Maxwell, E A; Sneddon, I N

    1963-01-01

    Concise Vector Analysis is a five-chapter introductory account of the methods and techniques of vector analysis. These methods are indispensable tools in mathematics, physics, and engineering. The book is based on lectures given by the author in the University of Ceylon.The first two chapters deal with vector algebra. These chapters particularly present the addition, representation, and resolution of vectors. The next two chapters examine the various aspects and specificities of vector calculus. The last chapter looks into some standard applications of vector algebra and calculus.This book wil

  16. Perfil de rendimiento en el campeonato del mundo de baloncesto (Ankara 2013) para personas con discapacidad intelectual: implicaciones en el sistema de elegibilidad

    OpenAIRE

    Pérez Tejero, Javier; Pinilla Arbex, Javier; Vanlandewijck, Yves

    2015-01-01

    [ES] Este estudio tiene por objetivo caracterizar el perfil de rendimiento individual del jugador de baloncesto con DI y distinguir entre los equipos ganadores y perdedores. Para ello, en línea con la literatura científica en el baloncesto convencional, se analizaron las estadísticas oficiales de juego del Campeonato del Mundo de baloncesto para jugadores con DI (Ankara, 2013).

  17. The Use of Alternate Ligno-cellulosic Raw Materials Banana (Musa sapientum) Ankara (Calotropis procera ) and Pineapple (Ananas comosus ) in Handmade Paper & their Blending with Waste Paper.

    OpenAIRE

    Atul Kumar

    2013-01-01

    The studies were made to established suitability of lingo-cellulosic raw materials namely leaf fibreBanana (Musa Sapientum), bast fibre Ankara (Calotropis Procera), & leaf fibre Pineapple (Ananas Comosus) for making pulps for handmade paper industry. This should help in providing a cost effective, good quality cellulosic raw material as an alternate to cost prohibitive traditionally used cotton hosiery waste traditionally used for manufacturing good quality handmade paper & it’s products. Th...

  18. The Effects of Sociotropic- Autonomic Personality Characteristics on the Motivation of the Workers: A Study Conducted In Accommodation Facilities in Ankara

    OpenAIRE

    ÖKTEM, Şükran; TURGUT, Hakan; TOKMAK, İsmail

    2013-01-01

    Because of the consideration that staff personality characteristics effect their motivation, staff of four and five star hotels, located within the city borders of Ankara, have been given priority while determining their sociotropic-autonomic personality traits. Subsequently, motivations of the said staff have been measured in accordance with both inner and external motivation tools in order to determine whether there is an effect of sociotropical-autonomic personality traits on inner and...

  19. Determination of pathogens causing damping-off and their pathogenicity in tomato seedbeds in Ankara (Ayaş, Beypazarı and Nallıhan districts) province

    OpenAIRE

    AŞKIN, Ayşe; KATIRCIOĞLU, Y. Zekai

    2009-01-01

    This research was carried out for determination of pathogens causing damping-off and their pathogenicity in tomato seedbeds in Ankara province (Ayaş, Beypazarı and Nallıhan districts) in 2003. Two hundred eleven samples of tomato seedlings, thought to be infected with damping off were collected from 42 seedbeds. Fusarium spp., Pythium spp., Rhizoctonia solani, Alternaria spp. and Aspergillus spp. were isolated from all collected  tomato seddlings. Fusarium spp., Pythium spp., R. solani a...

  20. VectorBase

    Data.gov (United States)

    U.S. Department of Health & Human Services — VectorBase is a Bioinformatics Resource Center for invertebrate vectors. It is one of four Bioinformatics Resource Centers funded by NIAID to provide web-based...

  1. Progress with viral vectored malaria vaccines: A multi-stage approach involving "unnatural immunity".

    Science.gov (United States)

    Ewer, Katie J; Sierra-Davidson, Kailan; Salman, Ahmed M; Illingworth, Joseph J; Draper, Simon J; Biswas, Sumi; Hill, Adrian V S

    2015-12-22

    Viral vectors used in heterologous prime-boost regimens are one of very few vaccination approaches that have yielded significant protection against controlled human malaria infections. Recently, protection induced by chimpanzee adenovirus priming and modified vaccinia Ankara boosting using the ME-TRAP insert has been correlated with the induction of potent CD8(+) T cell responses. This regimen has progressed to field studies where efficacy against infection has now been reported. The same vectors have been used pre-clinically to identify preferred protective antigens for use in vaccines against the pre-erythrocytic, blood-stage and mosquito stages of malaria and this work is reviewed here for the first time. Such antigen screening has led to the prioritization of the PfRH5 blood-stage antigen, which showed efficacy against heterologous strain challenge in non-human primates, and vectors encoding this antigen are in clinical trials. This, along with the high transmission-blocking activity of some sexual-stage antigens, illustrates well the capacity of such vectors to induce high titre protective antibodies in addition to potent T cell responses. All of the protective responses induced by these vectors exceed the levels of the same immune responses induced by natural exposure supporting the view that, for subunit vaccines to achieve even partial efficacy in humans, "unnatural immunity" comprising immune responses of very high magnitude will need to be induced. PMID:26476366

  2. Mineralogical, geochemical and micromorphological evaluation of the Plio-Quaternary paleosols and calcretes from Karahamzall, Ankara (Central Turkey

    Directory of Open Access Journals (Sweden)

    Küçükuysal Ceren

    2014-06-01

    Full Text Available We present the mineralogical, micromorphological, and geochemical characteristics of the paleosols and their carbonates from Karahamzall, Ankara (Central Turkey. The paleosols include calcretes of powdery to nodular forms and alternate with channel deposits. The presence of pedofeatures, such as clay cutans, floating grains, circumgranular cracks, MnO linings, secondary carbonate rims, traces of past bioturbation and remnants of root fragments are all the evidence of pedogenesis. Bw is the most common soil horizon showing subangular-angular blocky to granular or prismatic microstructures. Calcretes, on the other hand, are evaluated as semi-mature massive, nodular, tubular or powdery forms. The probable faunal and floral passages may also imply the traces of life from when these alluvial deposits were soil. The presence of early diagenetic palygorskite and dolomite together with high salinization, high calcification and low chemical index of alteration values are evidence of the formation of calcretes under arid and dry conditions. δ13C compositions of the carbonates ranging from -7.11 ‰ to -7.74 ‰ VPDB are comformable with the world pedogenic carbonates favouring the C4 vegetation; likely δ18O compositions of the carbonates are between -3.97 ‰ and -4.91 ‰ which are compatible with the paleosols formed under the influence of meteroic water in the vadose zone

  3. Evaluation of Sun Protection Habits and Melanocytic Nevi of Population Screened in a Shopping Mall in Ankara

    Directory of Open Access Journals (Sweden)

    Banu Öztürk

    2009-12-01

    Full Text Available Background and Design: The evaluation of sun protection habits, numbers and types of nevi in our community. Material and Method: A stand was built in a big mall in Ankara where 764 patients were screened for the presence of nevi in three working day periods during the month of May of 2005 and 2006. Lesions were evaluated with the help of digital dermatoscopy. In the study, sun protective practices, sunscreen using habits, dermatoscopic diagnosis of the lesions, numbers and the localization of the lesions were also recorded. Results: The study population consisted of 764 patients (438 female, 326 male with age ranging from 1 to 80 (33.7±13.7 years. 55.6% of them had skin type III, 47.3% had sunburn history. Most of the patients (44.1% were not using sunscreens. Hats and umbrellas (40.3% were the most common accessories used for protection. 904 lesions of 764 patients examined by dermatoscopy revealed that the most common diagnosis was nevi. Two patients were diagnosed with having cutaneous melanoma or basal cell carcinoma. Conclusion: Our findings have shown that the general population is not aware of the risks of sun exposure or the appropriate ways for sun protection and that there is a necessity for educational programmes or campaigns about sun protection and nevi in our general population.

  4. Sensitivity analyses for the DTMs derived from Unmanned Aerial Vehicle (UAV) in gully erosion mapping: Nallihan badland area (Ankara, Turkey)

    Science.gov (United States)

    Avdan, Ugur; Gorum, Tolga; Comert, Resul; Nefeslioglu, Hakan

    2015-04-01

    The main purpose of this study is to evaluate the spatial resolutions for the Digital Terrain Models (DTMs) derived from Unmanned Aerial Vehicle (UAV) in gully erosion mapping. For the purpose, Nallihan badland area (Ankara, Turkey) was selected to be the experimental site. The investigations were carried out in 3 stages; (i) production of the DTMs having 3 cm and 9 cm spatial resolutions by using the orthophoto imagery acquired from the UAV at 97.5 m and 292.4 m altitudes, respectively, (ii) Terrestrial Laser Scanning (TLS) of the experimental site and production of the DTMs derived from the TLS data resampled at 3 cm and 9 cm spatial resolutions, and (iii) spatial and profile comparisons of the derived data. The average altitude differences were obtained on the intervals (-0.1, 0.1) m and (-0.2, 0.2) m for the comparisons between TLS-3cm and UAV-3cm, and TLS-9cm and UAV-9cm data, respectively. Additionally, considering the profile comparisons, it is revealed that depending on the decreasing of spatial resolution, the erosion rates calculated from the DTMs increase artificially.

  5. The Rates of Undergoing Cancer Screening Among Family Physicians Aged 40 and Older Working in Ankara Province

    Directory of Open Access Journals (Sweden)

    Ayşe Selda Tekiner

    2016-04-01

    Full Text Available Aim: Family physicians, as role models for their patients, self health behaviors are important. We aimed to investigate the rate of undergoing cancer screening among family physicians. Methods: This is a descriptive and questionnaire-based study. Although we aimed to interview 1100 family physicians aged 40 or older working at family health centers of Ankara, the study was performed with 453 physicians. The questionnaire form comprised of the doctors’ opinions about cancer screening tests, and the situations of undergoing screening tests. Results: The rates of mammography and Pap smear test were 60% and 59% respectively among female doctors. The rates of fecal occult blood testing and colonoscopy were 2.7% and 8.6% respectively. The physicians’ responses to the question “family physicians should be responsible for cancer screening tests in populations they serve” were: “I totally agree": 9.3%; “I agree ": 23.6%; “I am undecided": 21.6%; “I disagree": 36.9%; "I strongly disagree": 8.6% Conclusion: Family physicians who have the responsibility of public health should also undergo screening tests regularly. The importance of protecting own health should be stressed at both undergraduate and postgraduate training programs. Special permits granted by administrators for health checks may also be encouraging.

  6. Exposure of newborns to aflatoxin M1 and B1 from mothers' breast milk in Ankara, Turkey.

    Science.gov (United States)

    Gürbay, A; Sabuncuoğlu, S Atasayar; Girgin, G; Sahin, G; Yiğit, S; Yurdakök, M; Tekinalp, G

    2010-01-01

    Aflatoxins (AFs) are important risks for human health due to their widespread presence in foods and environment. However, contamination risk of breast milk with different pollutants including AFs is high in today's life conditions. Since breast milk is a major nutrient for infants, feeding of infants with safe milk is essential. Therefore, the objective of this study was to determine the levels of AF M(1) and B(1) in breast milk samples collected from 75 mothers in Ankara, Turkey. AF M(1) and B(1) levels were investigated by high performance liquid chromatography (HPLC) with a fluorescence detector following an extraction procedure. The limit of detection was found to be 5 ng/l. Both AFs were detected in diverse degrees in all breast milk samples: The level of AF M(1) were in the ranges of 60.90-299.99 ng/l, and AF B(1) were in the ranges of 94.50-4123.80 ng/l. These results pointed out the exposure of mothers and neonates to AF M(1) and B(1), and the necessity of further research on mycotoxin contamination both in foods and biological fluids as well as protection strategies. PMID:19850097

  7. Strong, but Age-Dependent, Protection Elicited by a Deoxyribonucleic Acid/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine.

    Science.gov (United States)

    Chamcha, Venkateswarlu; Kannanganat, Sunil; Gangadhara, Sailaja; Nabi, Rafiq; Kozlowski, Pamela A; Montefiori, David C; LaBranche, Celia C; Wrammert, Jens; Keele, Brandon F; Balachandran, Harikrishnan; Sahu, Sujata; Lifton, Michelle; Santra, Sampa; Basu, Rahul; Moss, Bernard; Robinson, Harriet L; Amara, Rama Rao

    2016-01-01

    Background.  In this study, we analyzed the protective efficacy of a simian immunodeficiency virus (SIV) macaque 239 (SIVmac239) analogue of the clinically tested GOVX-B11 deoxyribonucleic acid (DNA)/modified vaccinia Ankara (MVA) human immunodeficiency virus vaccine. Methods.  The tested vaccine used a DNA immunogen mutated to mimic the human vaccine and a regimen with DNA deliveries at weeks 0 and 8 and MVA deliveries at weeks 16 and 32. Twelve weekly rectal challenges with 0.3 animal infectious doses of SIV sootey mangabey E660 (SIVsmE660) were administered starting at 6 months after the last immunization. Results.  Over the first 6 rectal exposures to SIVsmE660, <10-year-old tripartite motif-containing protein 5 (TRIM5)α-permissive rhesus macaques showed an 80% reduction in per-exposure risk of infection as opposed to a 46% reduction in animals over 10 years old; and, over the 12 challenges, they showed a 72% as opposed to a 10% reduction. Analyses of elicited immune responses suggested that higher antibody responses in the younger animals had played a role in protection. Conclusions.  The simian analogue of the GOVX-B11 HIV provided strong protection against repeated rectal challenges in young adult macaques. PMID:27006959

  8. Recombinant modified vaccinia virus Ankara expressing glycoprotein E2 of Chikungunya virus protects AG129 mice against lethal challenge.

    Directory of Open Access Journals (Sweden)

    Petra van den Doel

    2014-09-01

    Full Text Available Chikungunya virus (CHIKV infection is characterized by rash, acute high fever, chills, headache, nausea, photophobia, vomiting, and severe polyarthralgia. There is evidence that arthralgia can persist for years and result in long-term discomfort. Neurologic disease with fatal outcome has been documented, although at low incidences. The CHIKV RNA genome encodes five structural proteins (C, E1, E2, E3 and 6K. The E1 spike protein drives the fusion process within the cytoplasm, while the E2 protein is believed to interact with cellular receptors and therefore most probably constitutes the target of neutralizing antibodies. We have constructed recombinant Modified Vaccinia Ankara (MVA expressing E3E2, 6KE1, or the entire CHIKV envelope polyprotein cassette E3E26KE1. MVA is an appropriate platform because of its demonstrated clinical safety and its suitability for expression of various heterologous proteins. After completing the immunization scheme, animals were challenged with CHIV-S27. Immunization of AG129 mice with MVAs expressing E2 or E3E26KE1 elicited neutralizing antibodies in all animals and provided 100% protection against lethal disease. In contrast, 75% of the animals immunized with 6KE1 were protected against lethal infection. In conclusion, MVA expressing the glycoprotein E2 of CHIKV represents as an immunogenic and effective candidate vaccine against CHIKV infections.

  9. Custodial vector model

    DEFF Research Database (Denmark)

    Becciolini, Diego; Franzosi, Diogo Buarque; Foadi, Roshan;

    2015-01-01

    We analyze the Large Hadron Collider (LHC) phenomenology of heavy vector resonances with a $SU(2)_L\\times SU(2)_R$ spectral global symmetry. This symmetry partially protects the electroweak S-parameter from large contributions of the vector resonances. The resulting custodial vector model spectrum...

  10. Vector-borne Infections

    OpenAIRE

    Rosenberg, Ronald; Ben Beard, C.

    2011-01-01

    Infections with vector-borne pathogens are a major source of emerging diseases. The ability of vectors to bridge spatial and ecologic gaps between animals and humans increases opportunities for emergence. Small adaptations of a pathogen to a vector can have profound effects on the rate of transmission to humans.

  11. Rhotrix Vector Spaces

    Science.gov (United States)

    Aminu, Abdulhadi

    2010-01-01

    By rhotrix we understand an object that lies in some way between (n x n)-dimensional matrices and (2n - 1) x (2n - 1)-dimensional matrices. Representation of vectors in rhotrices is different from the representation of vectors in matrices. A number of vector spaces in matrices and their properties are known. On the other hand, little seems to be…

  12. Towards a universal vaccine for avian influenza: protective efficacy of modified Vaccinia virus Ankara and Adenovirus vaccines expressing conserved influenza antigens in chickens challenged with low pathogenic avian influenza virus.

    Science.gov (United States)

    Boyd, Amy C; Ruiz-Hernandez, Raul; Peroval, Marylene Y; Carson, Connor; Balkissoon, Devanand; Staines, Karen; Turner, Alison V; Hill, Adrian V S; Gilbert, Sarah C; Butter, Colin

    2013-01-11

    Current vaccines targeting surface proteins can drive antigenic variation resulting either in the emergence of more highly pathogenic viruses or of antigenically distinct viruses that escape control by vaccination and thereby persist in the host population. Influenza vaccines typically target the highly mutable surface proteins and do not provide protection against heterologous challenge. Vaccines which induce immune responses against conserved influenza epitopes may confer protection against heterologous challenge. We report here the results of vaccination with recombinant modified Vaccinia virus Ankara (MVA) and Adenovirus (Ad) expressing a fusion construct of nucleoprotein and matrix protein (NP+M1). Prime and boost vaccination regimes were trialled in different ages of chicken and were found to be safe and immunogenic. Interferon-γ (IFN-γ) ELISpot was used to assess the cellular immune response post secondary vaccination. In ovo Ad prime followed by a 4 week post hatch MVA boost was identified as the most immunogenic regime in one outbred and two inbred lines of chicken. Following vaccination, one inbred line (C15I) was challenged with low pathogenic avian influenza (LPAI) H7N7 (A/Turkey/England/1977). Birds receiving a primary vaccination with Ad-NP+M1 and a secondary vaccination with MVA-NP+M1 exhibited reduced cloacal shedding as measured by plaque assay at 7 days post infection compared with birds vaccinated with recombinant viruses containing irrelevant antigen. This preliminary indication of efficacy demonstrates proof of concept in birds; induction of T cell responses in chickens by viral vectors containing internal influenza antigens may be a productive strategy for the development of vaccines to induce heterologous protection against influenza in poultry. PMID:23200938

  13. Enhancing immune responses of EV71 VP1 DNA vaccine by co-inoculating plasmid IL-12 or GM-CSF expressing vector in mice.

    Science.gov (United States)

    Peng, X; Fang, X; Li, J; Kong, L; Li, B; Ding, X

    2016-01-01

    Enterovirus 71 (EV71) is a major causative viral agent for large outbreaks of hand, foot, and mouth disease in children and infants, yet there is no vaccine or effective antiviral treatment for severe EV71 infection. The immunogenicity of EV71 VP1 DNA vaccine and the immunoregulatory activity of interleukin-12 (IL-12) or granulocyte-monocyte colony stimulating factor (GM-CSF) were investigated. DNA vaccine plasmids, pcDNA-VP1, pcDNA-IL-12 and pcDNA-GM-CSF were constructed and inoculated into BALB/c mice with or without pcDNA-IL-12 or pcDNA-GM-CSF by intramuscular injection. Cellular and humoral immune responses were assessed by indirect ELISA, lymphocyte proliferation assays, cytokine release assay and FACS. The VP1 DNA vaccine had good immunogenicity and can induce specific humoral and cellular immunity in BALB/c mice, while IL-2 or GM-CSF plays an immunoadjuvant role and enhances specific immune responses. This study provides a frame of reference for the design of DNA vaccines against EV71. PMID:27188732

  14. Covariantised Vector Galileons

    CERN Document Server

    Hull, Matthew; Tasinato, Gianmassimo

    2015-01-01

    Vector galileons are ghost-free systems containing higher derivative interactions of vector fields. They break the vector gauge symmetry, and the dynamics of the longitudinal vector polarizations acquire a Galileon symmetry in an appropriate decoupling limit in Minkowski space. Using an ADM approach, we carefully reconsider the coupling with gravity of vector galileons, with the aim of studying the necessary conditions to avoid the propagation of ghosts. We develop arguments that put on a more solid footing the results previously obtained in the literature. Moreover, working in analogy with the scalar counterpart, we find indications for the existence of a `beyond Horndeski' theory involving vector degrees of freedom, that avoids the propagation of ghosts thanks to secondary constraints. In addition, we analyse a Higgs mechanism for generating vector galileons through spontaneous symmetry breaking, and we present its consistent covariantisation.

  15. Reducing the Genotoxic Potential of Retroviral Vectors

    OpenAIRE

    Ramezani, Ali; Hawley, Teresa S.; Hawley, Robert G.

    2008-01-01

    The recent development of leukemia in gene therapy patients with X-linked severe combined immunodeficiency disease due to retroviral vector insertional mutagenesis has prompted reassessment of the genotoxic potential of integrating vector systems. In this chapter, various strategies are described to reduce the associated risks of retroviral genomic integration. These include deletion of strong transcriptional enhancer-promoter elements in the retroviral long terminal repeats, flanking the ret...

  16. Index Sets and Vectorization

    Energy Technology Data Exchange (ETDEWEB)

    Keasler, J A

    2012-03-27

    Vectorization is data parallelism (SIMD, SIMT, etc.) - extension of ISA enabling the same instruction to be performed on multiple data items simultaeously. Many/most CPUs support vectorization in some form. Vectorization is difficult to enable, but can yield large efficiency gains. Extra programmer effort is required because: (1) not all algorithms can be vectorized (regular algorithm structure and fine-grain parallelism must be used); (2) most CPUs have data alignment restrictions for load/store operations (obey or risk incorrect code); (3) special directives are often needed to enable vectorization; and (4) vector instructions are architecture-specific. Vectorization is the best way to optimize for power and performance due to reduced clock cycles. When data is organized properly, a vector load instruction (i.e. movaps) can replace 'normal' load instructions (i.e. movsd). Vector operations can potentially have a smaller footprint in the instruction cache when fewer instructions need to be executed. Hybrid index sets insulate users from architecture specific details. We have applied hybrid index sets to achieve optimal vectorization. We can extend this concept to handle other programming models.

  17. Research of Stability Problems on Ankara-Konya High Speed Railway Line (Turkey) using Ground Penetrating Radar and Petrographical Methods

    Science.gov (United States)

    Kadioglu, S.; Kadioglu, Y. K.

    2012-04-01

    The aim of the study is to research the stability problems according to rock properties and their discontinuities such as fractures, faults and karstic cavities on the new high-speed railway line between the capital city Ankara and the largest city Konya in Turkey. The Ankara-Konya high speed railway including a tunnel managed from The Turkish State Railways (TCDD). Geological surveys, polarizing microscope and confocal Raman spectrometry studies were used to determine rock properties. Ground penetrating radar (GPR) method was used to determine faults, fractures and karstic cavities. The railway line has been mainly constructed on inner Tauride Ocean suture of the Central Anatolia. The basement unit of the railway line mainly has been composed of ophiolitic complex of the inner Tauride Ocean. The main lithology of this ophiolitic complex has been formed by radiolarite, pelagic sediments, dolarite, gabbro, serpentinized peridotite and limestone blocks. The Jurassic alloctonous limestone which has been thrust on the ophiolitic complex. Neogene cover young units with minor amount of Alluvium deposits have been formed by the upper litholgy in the region. The serpentinite and altered radiolarite formation are formed by lubricous ground for the railway line in the region. A RAMAC CUII GPR system was used with a bi-static 100 MHz center band shielded antenna to acquire profile data. Totaly 35 km was surveyed on different parts of the railway line by considering the results of the geologic research and petrograpical studies. When we started to study, rail construction of some parts of the line had already been completed. Therefore, during studies, we gathered the data on the backfilled way on the three parallel profiles spaced 1m apart or on the service way next to the railway line. There was a tunnel on the line. We also gathered two parallel profiles data on the tunnel and four profiles data next to the tunnel to evaluate the stability according to the discontinuities

  18. Jurassic–Paleogene intraoceanic magmatic evolution of the Ankara Mélange, north-central Anatolia, Turkey

    Directory of Open Access Journals (Sweden)

    E. Sarifakioglu

    2014-02-01

    Full Text Available Oceanic rocks in the Ankara Mélange along the Izmir–Ankara–Erzincan suture zone (IAESZ in north-central Anatolia include locally coherent ophiolite complexes (~ 179 Ma and ~ 80 Ma, seamount or oceanic plateau volcanic units with pelagic and reefal limestones (96.6 ± 1.8 Ma, metamorphic rocks with ages of 256.9 ± 8.0 Ma, 187.4 ± 3.7 Ma, 158.4 ± 4.2 Ma, and 83.5 ± 1.2 Ma indicating northern Tethys during the late Paleozoic through Cretaceous, and subalkaline to alkaline volcanic and plutonic rocks of an island arc origin (~ 67–63 Ma. All but the arc rocks occur in a shale–graywacke and/or serpentinite matrix, and are deformed by south-vergent thrust faults and folds that developed in the middle to late Eocene due to continental collisions in the region. Ophiolitic volcanic rocks have mid-ocean ridge (MORB and island arc tholeiite (IAT affinities showing moderate to significant large ion lithophile elements (LILE enrichment and depletion in Nb, Hf, Ti, Y and Yb, which indicate the influence of subduction-derived fluids in their melt evolution. Seamount/oceanic plateau basalts show ocean island basalt (OIB affinities. The arc-related volcanic rocks, lamprophyric dikes and syenodioritic plutons exhibit high-K shoshonitic to medium- to high-K calc-alkaline compositions with strong enrichment in LILE, rare earth elements (REE and Pb, and initial εNd values between +1.3 and +1.7. Subalkaline arc volcanic units occur in the northern part of the mélange, whereas the younger alkaline volcanic rocks and intrusions (lamprophyre dikes and syenodioritic plutons in the southern part. The late Permian, Early to Late Jurassic, and Late Cretaceous amphibole-epidote schist, epidote-actinolite, epidote-chlorite and epidote-glaucophane schists represent the metamorphic units formed in a subduction channel in the northern Neotethys. The Middle to Upper Triassic neritic limestones spatially associated with the

  19. Frequency, risk factors and preventive approach to fall among aged population living in a nursing home in Ankara

    Directory of Open Access Journals (Sweden)

    Evren Kibar

    2015-02-01

    Full Text Available AIM: Increase in aged population in number brings along the risk of falls and fall-related injuries among elderly. It has been reported that almost 60% of falls occur in nursing homes and majority of admissions to emergency departments due to falls consist of elderly. The purpose of this study conducted in a nursing home in Ankara was to determine the frequency of falls and risk factors, and to clear out the opinions and views of the participants on planning and promoting interventions for prevention. METHOD: This cross-sectional study was carried out among 60 years of age and older residents who lived in a nursing home. Data of the study was collected via face to face interviewing technique. The questionnaire consisted of four sections including socio-demographic characteristics, health status of the participants, healthy/risky behavior and fall related characteristics. RESULTS: Mean age of the 75 female and 59 male participants involved in the study was 73.99+/-7.18. Females were found to fall more in frequency than males (p>0.05. It was found that nearly half of the males (47.5% and more than half of the females (56.0% fell at least once within the previous year. Number of falls were higher among 75 years of age and older participants compared to the other age groups (p=0.003. Compared to the participants with fall background, aged people without fall background gave more correct answers in number to the questions which were asked to assess the knowledge on falls. Six out of 20 answers were statistically significantly correct (p <0.05. CONCLUSION: Individual and environmental interventions to be continued both inside and outside the institutions in order to prevent falls. [TAF Prev Med Bull 2015; 14(1.000: 23-32

  20. EFFECTS OF PERSONALITY TRAITS OF SPORTS-HEALTH CENTER EMPLOYEES ON SERVICE ORIENTATION IN PROVINCE OF ANKARA

    Directory of Open Access Journals (Sweden)

    Serdar

    2016-04-01

    Full Text Available This study was made for the purpose of researching the effects of personality traits of sports-health center personnel on service orientation in province of Ankara. As data collection tool, “Five Factor Personality Inventory” developed by Goldberg in 1990 and a version of “Customer Centricity Scale” developed by Brown et al. (2000, which was localized and tested for validity-reliability by Serçeoğlu (2013, were used. In the mentioned scale, the factor load values representing the structure validity of items constituting the service orientation change between 0,85 and 0,97. Cronbach Alpha reliability coefficient calculated for the reliability of the scale was calculated as 0,98 (Serçeoğlu, 2013. Data collected from 201 participants working at 19 businesses were analyzed by processing in SPSS-21 package software. The conclusion of personality traits of personnel working at sports-health centers having a significant effect on the service orientation, also personality traits sub-factors having a significant effect on service orientation was reached. When the effect of personality traits of sports-health business employees’ belonging to sub-factors of five factor personality inventory on service orientation is looked at; the sub-factors of agreeableness, responsibility and being open to new ideas are seen to have significant effect, the sub-factors of extroversion and emotional balance are seen not to have significant effect. The conclusion of significant difference between the personality traits and service orientation of the participants according to their status in the department they are employed was reached. It was identified that there were no significant difference between personality traits and service orientation according to gender, marital status and duration of working in the industry of the employees.

  1. Incorporation of 4-1BB ligand into an adenovirus vaccine vector increases the number of functional antigen-specific CD8 T cells and enhances the duration of protection against influenza-induced respiratory disease.

    Science.gov (United States)

    Moraes, Theo J; Lin, Gloria H Y; Wen, Tao; Watts, Tania H

    2011-08-26

    T cell based influenza vaccines offer the potential for cross protective immunity to multiple clades of influenza virus. Here we explored the effect of increasing CD8 T cell responses during intranasal vaccination by incorporating a T cell costimulator, 4-1BBL. Inclusion of 4-1BBL in an influenza nucleoprotein (NP)-containing adenoviral vector increased the number of NP-specific CD8 T cells and lowered the vaccine dose required for short-term protection from influenza-induced disease in mice. At higher vaccine doses, the inclusion of 4-1BBL increased the duration of protection of mice from influenza-induced mortality. Bone marrow chimera experiments revealed that the major effects of 4-1BBL were directly on αβ T cells with minor additional effects through cells other than αβ T cells. The implications of these findings are that including 4-1BBL or adjuvants that induce 4-1BBL expression may be of benefit in a vaccine setting for enhancing the magnitude and duration of T cell responses to influenza virus. PMID:21704101

  2. Enhanced protective immunity of the chimeric vector-based vaccine rAdV-SFV-E2 against classical swine fever in pigs by a Salmonella bacterial ghost adjuvant.

    Science.gov (United States)

    Xia, Shui-Li; Lei, Jian-Lin; Du, Mingliang; Wang, Yimin; Cong, Xin; Xiang, Guang-Tao; Li, Lian-Feng; Yu, Shenye; Du, Enqi; Liu, Siguo; Sun, Yuan; Qiu, Hua-Ji

    2016-01-01

    Classical swine fever (CSF) is a highly contagious swine disease caused by classical swine fever virus (CSFV). Previously, we demonstrated that rAdV-SFV-E2, an adenovirus-delivered, Semliki Forest virus replicon-vectored marker vaccine against CSF, is able to protect pigs against lethal CSFV challenge. From an economical point of view, it will be beneficial to reduce the minimum effective dose of the vaccine. This study was designed to test the adjuvant effects of Salmonella enteritidis-derived bacterial ghosts (BG) to enhance the protective immunity of rAdV-SFV-E2 in pigs. Groups of 5-week-old pigs (n = 4) were immunized intramuscularly twice with 10(5) median tissue culture infective doses (TCID50) rAdV-SFV-E2 combined with 10(10) colony forming units (CFU) BG, 10(6) or 10(5) TCID50 rAdV-SFV-E2 alone or 10(10) CFU BG alone at an interval of 3 weeks, and challenged with the highly virulent CSFV Shimen strain at 1 week post-booster immunization. The results show that the pigs inoculated with 10(5) TCID50 rAdV-SFV-E2 plus BG or 10(6) TCID50 rAdV-SFV-E2 alone were completely protected from lethal CSFV challenge, in contrast with the pigs vaccinated with 10(5) TCID50 rAdV-SFV-E2 or BG alone, which displayed partial or no protection following virulent challenge. The data indicate that BG are a promising adjuvant to enhance the efficacy of rAdV-SFV-E2 and possibly other vaccines. PMID:27301745

  3. On harmonic vector fields

    OpenAIRE

    Konderak, Jerzy J.

    1992-01-01

    A tangent bundle to a Riemannian manifold carries various metrics induced by a Riemannian tensor. We consider harmonic vector fields with respect to some of these metrics . We give a simple proof that a vector field on a compact manifold is harmonic with respect to the Sasaki metric on TM if and only if it is parallel. We also consider the metrics II and I + II on a tangent bundle (cf. [YI]) and harmonic vector fields generated by them.

  4. Implicit Real Vector Automata

    Directory of Open Access Journals (Sweden)

    Jean-François Degbomont

    2010-10-01

    Full Text Available This paper addresses the symbolic representation of non-convex real polyhedra, i.e., sets of real vectors satisfying arbitrary Boolean combinations of linear constraints. We develop an original data structure for representing such sets, based on an implicit and concise encoding of a known structure, the Real Vector Automaton. The resulting formalism provides a canonical representation of polyhedra, is closed under Boolean operators, and admits an efficient decision procedure for testing the membership of a vector.

  5. Selectively Balancing Unit Vectors

    OpenAIRE

    Blokhuis, Aart; Chen, Hao

    2016-01-01

    A set $U$ of unit vectors is selectively balancing if one can find two disjoint subsets $U^+$ and $U^-$, not both empty, such that the Euclidean distance between the sum of $U^+$ and the sum of $U^-$ is smaller than $1$. We prove that, to guarantee a selectively balancing set, $n \\log n$ unit vectors suffice for sufficiently large $n$, but $\\tfrac{1}{23} n \\log n$ unit vectors won't be enough for infinitely many $n$.

  6. Symbolic computer vector analysis

    Science.gov (United States)

    Stoutemyer, D. R.

    1977-01-01

    A MACSYMA program is described which performs symbolic vector algebra and vector calculus. The program can combine and simplify symbolic expressions including dot products and cross products, together with the gradient, divergence, curl, and Laplacian operators. The distribution of these operators over sums or products is under user control, as are various other expansions, including expansion into components in any specific orthogonal coordinate system. There is also a capability for deriving the scalar or vector potential of a vector field. Examples include derivation of the partial differential equations describing fluid flow and magnetohydrodynamics, for 12 different classic orthogonal curvilinear coordinate systems.

  7. Monopole vector spherical harmonics

    International Nuclear Information System (INIS)

    Eigenfunctions of total angular momentum for a charged vector field interacting with a magnetic monopole are constructed and their properties studied. In general, these eigenfunctions can be obtained by applying vector operators to the monopole spherical harmonics in a manner similar to that often used for the construction of the ordinary vector spherical harmonics. This construction fails for the harmonics with the minimum allowed angular momentum. These latter form a set of vector fields with vanishing covariant curl and covariant divergence, whose number can be determined by an index theorem

  8. Monopole vector spherical harmonics

    CERN Document Server

    Weinberg, Erick J

    1994-01-01

    Eigenfunctions of total angular momentum for a charged vector field interacting with a magnetic monopole are constructed and their properties studied. In general, these eigenfunctions can be obtained by applying vector operators to the monopole spherical harmonics in a manner similar to that often used for the construction of the ordinary vector spherical harmonics. This construction fails for the harmonics with the minimum allowed angular momentum. These latter form a set of vector fields with vanishing covariant curl and covariant divergence, whose number can be determined by an index theorem.

  9. Vectors and their applications

    CERN Document Server

    Pettofrezzo, Anthony J

    2005-01-01

    Geared toward undergraduate students, this text illustrates the use of vectors as a mathematical tool in plane synthetic geometry, plane and spherical trigonometry, and analytic geometry of two- and three-dimensional space. Its rigorous development includes a complete treatment of the algebra of vectors in the first two chapters.Among the text's outstanding features are numbered definitions and theorems in the development of vector algebra, which appear in italics for easy reference. Most of the theorems include proofs, and coordinate position vectors receive an in-depth treatment. Key concept

  10. Evolution of developments and applications of advanced thermal-hydraulics and neutronic codes. Conclusions from Annapolis Workshop and Ankara Seminar, Objectives of the Present Workshop

    International Nuclear Information System (INIS)

    In the nuclear reactor safety area, during the last 30-40 years, thermal-hydraulics has been one of the key disciplines for simulation and analysis of transient and accident scenarios and also for the definition of preventive and mitigative measures in relation to these scenarios. A workshop was organised by OECD/NEA-CSNI at Annapolis (1996) where codes, physical models, numeric and new computer architecture were examined. In parallel a Specialist meeting on instrumentation in two phase flows was held in Santa Barbara beginning of 1997 in order to investigate new techniques for getting measurements of new physical parameters necessary for assessing the new physical models. Among the different applications of thermal-hydraulic codes, the use of Best Estimate methods in safety evaluation is certainly one of the major challenges for which the safety and economic issues are quite important. For these reasons OECD/NEA-CSNI organised a seminar in Ankara in 1998 entirely devoted to the use of Best Estimate methods in thermal-hydraulics analysis. This seminar allowed to get a better view of where we were in such applications and which were the remaining problems and issues. The present workshop held in Barcelona beginning of year 2000 will be a good opportunity for providing an updated review of the gained progresses and for analysing if the objectives and programs are still progressing in the right direction. In order to do such exercise, we will first recall the questions which were raised in Annapolis and the main conclusions which were drawn from these questions. The conclusions of Ankara Meeting will be reviewed in a second step. Finally we will list the objectives of this workshop in Barcelona which is held in the continuity of Annapolis Workshop and Ankara Seminar. (authors)

  11. The Age and Geodynamic Evolution of the Metamorphic sole rocks from Izmir-Ankara-Erzıncan suture zone (Northern-Turkey)

    Science.gov (United States)

    Melih Çörtük, Rahmi; Faruk Çelik, Ömer; Özkan, Mutlu; Sherlock, Sarah C.; Marzoli, Andrea; Altıntaş, İsmail Emir; Topuz, Gültekin

    2016-04-01

    The İzmir-Ankara-Erzincan suture zone in northern Turkey is one of the major tectonic zones separating the Pontides to the North from the Anatolide-Tauride block and Kı rşehir Massif to the South. The accretionary complex of the İzmir-Ankara-Erzincan suture zone, near Artova, is composed mainly of peridotites with varying degree serpentinization, metamorphic rocks, basalt, sandstones, pelagic and neritic limestones. The metamorphic rocks are represented by amphibolite, garnet micaschit, calc-schist and marble. The metamorphic rocks were interpreted as the metamorphic sole rocks. Because; (i) They are tectonically located beneath the serpentinized peridotites. (ii) Foliation planes of both the amphibolites and mantle tectonites are parallel to each other. (iii) The metamorphic rocks are crosscut by non-metamorphic dolerite dikes which exhibite Nb and Ta depletion relative to Th enrichment on the N-MORB normalized multi-element spider diagram. The dolerite dikes display flat REE patterns (LaN/YbN=0.85-1.24). These geochemical signatures of the dolerite dikes are indicative of subduction component during their occurrences. Geochemical observations of the amphibolites suggest E-MORB- and OIB-like signatures (LaN/SmN= 1.39-3.14) and their protoliths are represented by basalt and alkali basaltic rocks. Amphiboles from the amphibolites are represented by calcic amphiboles (magnesio-hornblende, tchermakite and tremolite) and they yielded 40Ar-39Ar ages between 157.8 ± 3.6 Ma and 139 ± 11 Ma. These cooling ages were interpreted to be the intra-oceanic subduction/thrusting time of the İzmir-Ankara-Erzincan oceanic domain. This study was funded by TÜBİTAK (Project no: 112Y123).

  12. Petrogenetic Characteristics Of Oyaca Kedikayası Boyalık Adakites In SW Ankara (Central Anatolia, Turkey): Evidences For Slab Melt Metasomatism

    OpenAIRE

    Şen, Pınar; Şen, Erdal

    2013-01-01

    The Early Miocene Oyaca, Kedikayası and Boyalık dacites, situated approximately 50-60 km southwest of Ankara have affinities similar to adakitic rocks. They have porphyritic texture with a variable amount of plagioclase feldspar, hornblende and lesser biotite phenocrysts and a groundmass of plagioclase and quartz microcrysts. They have high Sr/Y (55-79 ppm) and (La/Yb)n (21-32 ppm) ratios, and low Y (10-19 ppm) and heavy rare earth element contents. According to their SiO2 (62.3-69.70 % wt.) ...

  13. PETROGENETIC CHARACTERISTICS OF OYACA – KEDİKAYASI – BOYALIK ADAKITES IN SW ANKARA (CENTRAL ANATOLIA, TURKEY): EVIDENCE FOR SLAB MELT METASOMATISM

    OpenAIRE

    Şen, Pınar; Şen, Erdal

    2013-01-01

    The Early Miocene Oyaca, Kedikayası and Boyalık dacites, situated approximately 50-60 km southwest of Ankara have affinities similar to adakitic rocks. They have porphyritic texture with a variable amount of plagioclase feldspar, hornblende and lesser biotite phenocrysts and a groundmass of plagioclase and quartz microcrysts. They have high Sr/Y (55-79 ppm) and (La/Yb)n (21-32 ppm) ratios, and low Y (10-19 ppm) and heavy rare earth element contents. According to their SiO2 (62.3-69.70 % wt.) ...

  14. Petrogenesis of the Refahiye Ophiolite and its Tectonic Significance for Neotethyan Ophiolites Along the İzmir-Ankara-Erzincan Suture Zone

    OpenAIRE

    SARIFAKIOĞLU, ENDER; WINCHESTER, HAYRETTİN ÖZEN & JOHN A.

    2009-01-01

    The Refahiye ophiolite, situated near Erzincan in the eastern part of the İzmir-Ankara-Erzincan Suture Zone (İAESZ), is one of the best exposures of oceanic lithosphere in the northern branch of the Neotethyan Ocean. The ophiolite, mainly thrust southwards, transported on an ophiolitic mélange, over the Early Triassic-Campanian Munzur Limestone of the Anatolide-Tauride Platform, was also emplaced by north-directed backthrusting onto the Pontides in the Late Cretaceous. It displays an almost c...

  15. Construction of recombinant adenoviral vector co-expressing interleukin-7 and enhanced green fluorescent protein%IL-7和EGFP双基因共表达重组腺病毒载体的构建

    Institute of Scientific and Technical Information of China (English)

    宁昌; 余长林; 李建军; 胡锴勋

    2011-01-01

    Objective:To construct the adenoviral vector co - expressing interleukin - 7( IL -7 ) and enhanced green fluorescent protein( EGFP),to lay a experimental foundation for further study on the infection into stem cell. Methods: The target gene IL -7 was cloned into the shuttle plasmid expressed the report gene EGFP. Then the re-combinant shuttle plasmid was transformed into Dh5a bacteria to recombine with backbone vector pAdxsi. Next,the plasmid pAd - EGFP - mIL7 was amplified in H293 cells and purifired, then the viral titer was determined. Results: The recombinanted shuttle plasmid pShuttle - EGFP - mIL7 digested with restriction endonucleases was confirmed by two products which length were respectively about 0. 5kb and 5. 1kb; the recombinanted plasmid pAdxsi - EGFP -mIL7 digested with restriction endonucleases was confirmed by seven products which length were respectively about 14K,11.8K,3. Lkb,2.66kb,2.47K,1.45K and 0.6K; recombinant adenoviral amplifired with titer of 2×l010pfu/ ml. Conclusion: The recombinant adenoviral vector pAdxsi - EGFP - mIL7 was successfully constructed.%目的:构建白细胞介素7(IL-7)和增强型绿色荧光蛋白(EGFP)共表达的重组腺病毒载体,为进一步感染干细胞奠定基础.方法:将目的基因IL-7克隆到含有报告基因EGFP的穿梭质粒中,然后再将构建的重组穿梭质粒转移至pAdxsi载体中,构建重组腺病毒载体质粒,继而在H293细胞中扩增,纯化后测定病毒滴度.结果:pShuttle-EGFP-mIL7重组穿梭质粒经酶切鉴定得到0.5kb和5.1kb 2条带;pAdxsi-EGFP-mIL7重组腺病毒载体质粒经酶切鉴定得到14K、11.8K、3.1kb、2.66kb、2.47K、1.45K、0.6K 7条带;TCID50法测定纯化后的病毒滴度为2×1010pfu/ml.结论:pAdxsi-EGFP-mIL7重组腺病毒载体构建成功.

  16. Cosmology with vector distortion

    CERN Document Server

    Jimenez, Jose Beltran

    2016-01-01

    We consider an extension of Weyl geometry with the most general connection linearly determined by a vector field. We discuss some of the geometrical properties within this framework and then we construct gravitational theories leading to an interesting class of vector-tensor theories with cosmological applications.

  17. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions or...... meromorphic (allowing poles as singularities) functions. There already exists a well-developed theory for iterative holomorphic dynamical systems, and successful relations found between iteration theory and flows of vector fields have been one of the main motivations for the recent interest in holomorphic...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...

  18. Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    The two branches of dynamical systems, continuous and discrete, correspond to the study of differential equations (vector fields) and iteration of mappings respectively. In holomorphic dynamics, the systems studied are restricted to those described by holomorphic (complex analytic) functions or...... vector fields. Since the class of complex polynomial vector fields in the plane is natural to consider, it is remarkable that its study has only begun very recently. There are numerous fundamental questions that are still open, both in the general classification of these vector fields, the decomposition...... of parameter spaces into structurally stable domains, and a description of the bifurcations. For this reason, the talk will focus on these questions for complex polynomial vector fields....

  19. Line Integral of a Vector.

    Science.gov (United States)

    Balabanian, Norman

    This programed booklet is designed for the engineering student who understands and can use vector and unit vector notation, components of a vector, parallel law of vector addition, and the dot product of two vectors. Content begins with work done by a force in moving a body a certain distance along some path. For each of the examples and problem…

  20. An investigation on wind energy potential and small scale wind turbine performance at İncek region – Ankara, Turkey

    International Nuclear Information System (INIS)

    Highlights: • Weibull parameters for İncek region were calculated using five different methods. • Wind power density was calculated using the best representative Weibull parameters. • Energy generation of three small scale wind turbines were calculated. • Two wind turbines can supply yearly energy need of an average household in Turkey. - Abstract: Renewable energy resources increased their importance in the last decades due to environmental pollution problems. Additionally, the fact that fossil fuels such as oil, coal, and natural gas will be depleted in near future encourages researchers to make investigations on alternative energy resources. Wind energy, which is one of the most used alternative resources, has a great potential. In this study, Weibull parameters at İncek region of Ankara (the capital city of Turkey), where Atılım University campus is located, were determined for four different seasons and for twelve months in order to accomplish wind speed characterization at the region. Wind speed data at 20 m and 30 m heights were collected from a measurement station installed at Atılım University campus area. The data were taken as 1 min average values for a one year period between June 2012 and June 2013. Hourly average wind speed values for each height were derived using the collected wind data. Weibull parameters were calculated with five different methods using the derived hourly average wind speed values. According to root mean square error analyses, the best methods for which Weibull distribution fits the actual wind data were determined as power density and empirical methods. The power and energy density values for the region were also calculated for each season and each month. It was revealed that the maximum power density is encountered in March with about 98 (W/m2). Since this power density indicates that large scale wind turbine use is not a good option at the region, the performances of three different small scale wind turbines were

  1. Afforestation areas defined by GIS in Gölbaşi specially protected area Ankara/Turkey.

    Science.gov (United States)

    Dilek, E Figen; Sahin, Sükran; Yilmazer, Ilyas

    2008-09-01

    This paper concentrates on determining the areas for afforestation and the development of conservation strategies and actions in the case where there is high demand for the conservation of a particular land area. The analysis of hydrological landscape structure and of erodibility was prerequisite in the methodological design considering the site-specific natural landscape characteristics of the study area. The Gölbaşi Specially Protected Area (SPA) being the case area has many local environmental disturbances, especially with respect to its hydrological system, and the area is beset by increasing demands for its use by the burgeoning human population. It is obviously clear that the present intensive demand for recreational use will be forecasted further increase in the future. The count of rural residences is estimated to increase by 50% over the next decade. This intensive demand shall further strain the carrying capacity of the ecological milieu, which has already suffered to a significant degree because of the present urban and rural activities. The Gölbaşi district is located only 20 km from the city center of Ankara, and its surroundings were legally designated to be a Specially Protected Area primarily for the existence of lacustral and fluvial systems where two interconnected lakes exist: Mogan and Eğmir Lakes. Essentially, the continuity of the lacustral and fluvial system of Lakes Mogan and Eğmir depends on the preservation and improvement of the water sources. However, interconnected surface water bodies of these lakes are actually quite contaminated, and a decline in the water flow from Mogan to Eğmir has been observed. For the elaboration of the present method, required conventional maps (at 1/25,000 scale) of topography (for slope analysis) and geology (for erodibility and permeability analysis) were transferred to computer media using AutoCAD R.14 software. The rectification of the transferred data was done using ERDAS Imagine 8.3. All data

  2. ON VECTOR NETWORK EQUILIBRIUM PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Guangya CHEN

    2005-01-01

    In this paper we define a concept of weak equilibrium for vector network equilibrium problems.We obtain sufficient conditions of weak equilibrium points and establish relation with vector network equilibrium problems and vector variational inequalities.

  3. The Vector Space as a Unifying Concept in School Mathematics.

    Science.gov (United States)

    Riggle, Timothy Andrew

    The purpose of this study was to show how the concept of vector space can serve as a unifying thread for mathematics programs--elementary school to pre-calculus college level mathematics. Indicated are a number of opportunities to demonstrate how emphasis upon the vector space structure can enhance the organization of the mathematics curriculum.…

  4. GAP Land Cover - Vector

    Data.gov (United States)

    Minnesota Department of Natural Resources — This vector dataset is a detailed (1-acre minimum), hierarchically organized vegetation cover map produced by computer classification of combined two-season pairs...

  5. Tagged Vector Contour (TVC)

    Data.gov (United States)

    Kansas Data Access and Support Center — The Kansas Tagged Vector Contour (TVC) dataset consists of digitized contours from the 7.5 minute topographic quadrangle maps. Coverage for the state is incomplete....

  6. Understanding Vector Fields.

    Science.gov (United States)

    Curjel, C. R.

    1990-01-01

    Presented are activities that help students understand the idea of a vector field. Included are definitions, flow lines, tangential and normal components along curves, flux and work, field conservation, and differential equations. (KR)

  7. Vector hysteresis models

    Czech Academy of Sciences Publication Activity Database

    Krejčí, Pavel

    1991-01-01

    Roč. 2, - (1991), s. 281-292. ISSN 0956-7925 Keywords : vector hysteresis operator * hysteresis potential * differential inequality Subject RIV: BA - General Mathematics http://www.math.cas.cz/~krejci/b15p.pdf

  8. Vector Lattice Vortex Solitons

    Institute of Scientific and Technical Information of China (English)

    WANG Jian-Dong; YE Fang-Wei; DONG Liang-Wei; LI Yong-Ping

    2005-01-01

    @@ Two-dimensional vector vortex solitons in harmonic optical lattices are investigated. The stability properties of such solitons are closely connected to the lattice depth Vo. For small Vo, vector vortex solitons with the total zero-angular momentum are more stable than those with the total nonzero-angular momentum, while for large Vo, this case is inversed. If Vo is large enough, both the types of such solitons are stable.

  9. Support vector machines applications

    CERN Document Server

    Guo, Guodong

    2014-01-01

    Support vector machines (SVM) have both a solid mathematical background and good performance in practical applications. This book focuses on the recent advances and applications of the SVM in different areas, such as image processing, medical practice, computer vision, pattern recognition, machine learning, applied statistics, business intelligence, and artificial intelligence. The aim of this book is to create a comprehensive source on support vector machine applications, especially some recent advances.

  10. Implicit Real Vector Automata

    OpenAIRE

    Jean-François Degbomont; Julien Brusten; Bernard Boigelot

    2010-01-01

    This paper addresses the symbolic representation of non-convex real polyhedra, i.e., sets of real vectors satisfying arbitrary Boolean combinations of linear constraints. We develop an original data structure for representing such sets, based on an implicit and concise encoding of a known structure, the Real Vector Automaton. The resulting formalism provides a canonical representation of polyhedra, is closed under Boolean operators, and admits an efficient decision procedure for testing the ...

  11. Vector financial rogue waves

    Energy Technology Data Exchange (ETDEWEB)

    Yan, Zhenya, E-mail: zyyan@mmrc.iss.ac.cn [Key Laboratory of Mathematics Mechanization, Institute of Systems Science, AMSS, Chinese Academy of Sciences, Beijing 100190 (China)

    2011-11-21

    The coupled nonlinear volatility and option pricing model presented recently by Ivancevic is investigated, which generates a leverage effect, i.e., stock volatility is (negatively) correlated to stock returns, and can be regarded as a coupled nonlinear wave alternative of the Black–Scholes option pricing model. In this Letter, we analytically propose vector financial rogue waves of the coupled nonlinear volatility and option pricing model without an embedded w-learning. Moreover, we exhibit their dynamical behaviors for chosen different parameters. The vector financial rogue wave (rogon) solutions may be used to describe the possible physical mechanisms for the rogue wave phenomena and to further excite the possibility of relative researches and potential applications of vector rogue waves in the financial markets and other related fields. -- Highlights: ► We investigate the coupled nonlinear volatility and option pricing model. ► We analytically present vector financial rogue waves. ► The vector financial rogue waves may be used to describe the extreme events in financial markets. ► This results may excite the relative researches and potential applications of vector rogue waves.

  12. Vector financial rogue waves

    International Nuclear Information System (INIS)

    The coupled nonlinear volatility and option pricing model presented recently by Ivancevic is investigated, which generates a leverage effect, i.e., stock volatility is (negatively) correlated to stock returns, and can be regarded as a coupled nonlinear wave alternative of the Black–Scholes option pricing model. In this Letter, we analytically propose vector financial rogue waves of the coupled nonlinear volatility and option pricing model without an embedded w-learning. Moreover, we exhibit their dynamical behaviors for chosen different parameters. The vector financial rogue wave (rogon) solutions may be used to describe the possible physical mechanisms for the rogue wave phenomena and to further excite the possibility of relative researches and potential applications of vector rogue waves in the financial markets and other related fields. -- Highlights: ► We investigate the coupled nonlinear volatility and option pricing model. ► We analytically present vector financial rogue waves. ► The vector financial rogue waves may be used to describe the extreme events in financial markets. ► This results may excite the relative researches and potential applications of vector rogue waves.

  13. The Vector Curvaton

    CERN Document Server

    Navarro, Andres A

    2013-01-01

    We analyze a massive vector field with a non-canonical kinetic term in the action, minimally coupled to gravity, where the mass and kinetic function of the vector field vary as functions of time during inflation. The vector field is introduced following the same idea of a scalar curvaton, which must not affect the inflationary dynamics since its energy density during inflation is negligible compared to the total energy density in the Universe. Using this hypothesis, the vector curvaton will be solely responsible for generating the primordial curvature perturbation \\zeta. We have found that the spectra of the vector field perturbations are scale-invariant in superhorizon scales due to the suitable choice of the time dependence of the kinetic function and the effective mass during inflation. The preferred direction, generated by the vector field, makes the spectrum of \\zeta depend on the wavevector, i.e. there exists statistical anisotropy in \\zeta. This is discussed principally in the case where the mass of th...

  14. VLSI circuit simulation using a vector computer

    Science.gov (United States)

    Mcgrogan, S. K.

    1984-01-01

    Simulation of circuits having more than 2000 active devices requires the largest, fastest computers available. A vector computer, such as the CYBER 205, can yield great speed and cost advantages if efforts are made to adapt the simulation program to the strengths of the computer. ASPEC and SPICE (1), two widely used circuit simulation programs, are discussed. ASPECV and VAMOS (5) are respectively vector adaptations of these two simulators. They demonstrate the substantial performance enhancements possible for this class of algorithm on the CYBER 205.

  15. Development and evaluation of a computer-aided diagnostic scheme for lung nodule detection in chest radiographs by means of two-stage nodule enhancement with support vector classification

    International Nuclear Information System (INIS)

    Purpose: To develop a computer-aided detection (CADe) scheme for nodules in chest radiographs (CXRs) with a high sensitivity and a low false-positive (FP) rate. Methods: The authors developed a CADe scheme consisting of five major steps, which were developed for improving the overall performance of CADe schemes. First, to segment the lung fields accurately, the authors developed a multisegment active shape model. Then, a two-stage nodule-enhancement technique was developed for improving the conspicuity of nodules. Initial nodule candidates were detected and segmented by using the clustering watershed algorithm. Thirty-one shape-, gray-level-, surface-, and gradient-based features were extracted from each segmented candidate for determining the feature space, including one of the new features based on the Canny edge detector to eliminate a major FP source caused by rib crossings. Finally, a nonlinear support vector machine (SVM) with a Gaussian kernel was employed for classification of the nodule candidates. Results: To evaluate and compare the scheme to other published CADe schemes, the authors used a publicly available database containing 140 nodules in 140 CXRs and 93 normal CXRs. The CADe scheme based on the SVM classifier achieved sensitivities of 78.6% (110/140) and 71.4% (100/140) with averages of 5.0 (1165/233) FPs/image and 2.0 (466/233) FPs/image, respectively, in a leave-one-out cross-validation test, whereas the CADe scheme based on a linear discriminant analysis classifier had a sensitivity of 60.7% (85/140) at an FP rate of 5.0 FPs/image. For nodules classified as ''very subtle'' and ''extremely subtle,'' a sensitivity of 57.1% (24/42) was achieved at an FP rate of 5.0 FPs/image. When the authors used a database developed at the University of Chicago, the sensitivities was 83.3% (40/48) and 77.1% (37/48) at an FP rate of 5.0 (240/48) FPs/image and 2.0 (96/48) FPs /image, respectively. Conclusions: These results compare favorably to those described for

  16. Comparison of Corporate Image a nd Patient Loyalty Perceptions of Outpatients and Inpatients: Example of a Training and Research Hospital in Ankara

    Directory of Open Access Journals (Sweden)

    Ömer Rıfkı Önder

    2014-12-01

    Full Text Available The purpose of this study is to determine the level of corporate image and patient loyalty of outpatients and inpatients who get services from a hospital and to evaluate the relationship between corporate images’ factors and patient loyalty. Totally 600 patients from a training and research hospitals in Ankara, formed the study sample. As a result, outpatients’ loyalty and image perceptions found medium level; while inpatients’ level found high. In addition, the effect of corporate image factors on patient loyalty was determined that there is a statistically significant , strong and positive correlation and 83% of patient loyalty is explained by corporate image factors. Based on the research findings, making improvements especially in quality and also physical, communication, social responsibility factors can obtain loyal patients. It is suggested to adopt different strategies to outpatients and inpatients while implementing these improvements.

  17. Ankara’daki Halk Kütüphanelerinde Halkla İlişkiler =Public Relations of Public Libraries in Ankara

    Directory of Open Access Journals (Sweden)

    Karadeniz, Şenol

    Full Text Available Bu çalışmada Ankara'daki halk kütüphanelerinin, kullanıcılarını sunulan hizmetler hakkında neden yeterince bilgilendiremedikleri ve kendilerini kullanıcılarına neden yeterince tanıtamadıkları konusu irdelenmiştir. Araştırmanın amacı, halk kütüphanelerinde uygulanabilecek halkla ilişkiler yöntemlerinin neler olduğunu, halk kütüphanelerinin planlı halkla ilişkiler faaliyetlerinde bulunmamalarının nedenlerini ve bu nedenlerin boyutunu, özelliklerini ortaya koymaktır. Araştırmanın evrenini Ankara Büyükşehir Belediyesi sınırları içinde hizmet veren Kültür ve Turizm Bakanlığı'na bağlı halk ve çocuk kütüphaneleri oluşturmaktadır. Önceden yapılandırılmış görüşme kapsamında halk kütüphanesi yöneticileriyle görüşülmüş, ayrıca araştırma kapsamındaki kütüphanelerde gözlem tekniği uygulanmıştır. Araştırmadan elde edilen bulgular ışığında, halk kütüphanelerinin sistematik halkla ilişkiler programları uygulamamaları nedeniyle, kütüphaneyi tanıtmada ve sunulan hizmetlere ilişkin kullanıcılarda olumlu görüş oluşturmada yetersiz kaldıkları anlaşılmıştır In this study the answers to the question "why the public libraries in Ankara could not inform their users about services off ered properly, and could not introduce themselves to users suffi ciently ?" were explicated. The goal of the study is to fi nd out which public relations methods can be used in libraries, and why libraries could not conduct planned public relations activities. The research universe consists of public libraries being administratively connected to Ministry of Culture and Tourism, which lie within the borders of Ankara Metropolitan Municipality. For the collection of data, pre-confi gured talks were applied to the managers who were working for the public libraries, and moreover the fulfi llment of library activities were observed. The fi ndings of the study indicate that, since

  18. Comparing adjuvanted H28 and modified vaccinia virus ankara expressingH28 in a mouse and a non-human primate tuberculosis model

    DEFF Research Database (Denmark)

    Billeskov, Rolf; Christensen, Jan Pravsgaard; Aagaard, Claus;

    2013-01-01

    Here we report for the first time on the immunogenicity and protective efficacy of a vaccine strategy involving the adjuvanted fusion protein "H28" (consisting of Ag85B-TB10.4-Rv2660c) and Modified Vaccinia Virus Ankara expressing H28. We show that a heterologous prime-boost regimen involving...... a significant positive correlation with protection at week 6 post infection, whereas the opposite was observed for post infection CD4 T cells producing only IFN-γ. Moreover, as a BCG booster vaccine in a clinically relevant non-human primate TB model, the H28/H28 vaccine strategy induced a slightly...... more prominent reduction of clinical disease and pathology for up to one year post infection compared to H28/MVA28. Taken together, our data showed that the adjuvanted subunit and MVA strategies led to different T cell subset combinations pre and post infection and that TNF-α/IL-2 double producing but...

  19. The Impac t of Managers’ Leadership Behaviors on Job Satisfaction of Employees: A Practice Used In The Lodging Facilities In Ankara

    Directory of Open Access Journals (Sweden)

    Arzu Kılıçlar

    2014-09-01

    Full Text Available The aim of this research, the impact of the managers' leadership behaviours on the employees' job satisfaction. For that purpose, it has been reachedall of the 14, 5 stars accommodation enterprices located in Ankara. From the employeesin these enterprices, datas are collected with the questionnaire formand in total 386 questionnaires are taken into consideration. The forms have 3 chapters. In the first chapter demographic datas are found, in the second chapter, the expressions to measure the managers' leadership behaviours are found, and in the thirdone, the expressions to measure the job satisfaction level of theemployeesare found. All these expressions are filled by the employees. Correlation analysis t-test and ANOVA was performed by using the data obtained from the questionnaire. A sall the datas are analysed, it is found that, there is a positiveway of meaningful relationship between the managers' leadership behavior and the employees' job satisfaction level.

  20. ANKARA ÜNİVERSİTESİ ZİRAAT FAKÜLTESİ YONCA EKİM ALANLARINDA GÖRÜLEN ÖNEMLİ HASTALIKLARIN BELİRLENMESİ

    OpenAIRE

    ONAR, Mihrace Çiğdem

    2005-01-01

    Bu çalışma ile Ankara Üniversitesi Ziraat Fakültesi Ayaş ve Haymana çiftlikleri ile Dışkapı yerleşkesindeki yonca ekim alanlarındaki önemli hastalıklar belirlenmiştir. 2003 - 2004 yıllarında belirtilen bölgelerden örnekler alınarak hastalık etmenlerinin teşhisleri yapılmıştır. Teşhisi yapılan funguslar; Leptotrochila medicaginis, Pseudopeziza medicaginis, Leveillula taurica, Peronospora trifoliorum, Phoma medicaginis var. medicaginis, Colletotrichum trifolii, Stemphylium botryosum, Stagon...

  1. Genetic Modification of Baculovirus Expression Vectors

    Institute of Scientific and Technical Information of China (English)

    Shu-fen Li; Hua-lin Wang; Zhi-hong Hu; Fei Deng

    2012-01-01

    As a protein expression vector,the baculovirus demonstrates many advantages over other vectors.With the development of biotechnology,baculoviral vectors have been genetically modified to facilitate high level expression of heterologous proteins in both insect and mammalian cells.These modifications include utilization of different promoters and signal peptides,deletion or replacement of viral genes for increasing protein secretion,integration of polycistronic expression cassette for producing protein complexes,and baculovirus pseudotyping,promoter accommodation or surface display for enhancing mammalian cell targeting gene delivery.This review summarizes the development and the current state of art of the baculovirus expression system.Further development of baculovirus expression systems will make them even more feasible and accessible for advanced applications.

  2. Vector WIMP Miracle

    CERN Document Server

    Abe, Tomohiro; Matsumoto, Shigeki; Seto, Osamu

    2012-01-01

    Weakly interacting massive particle (WIMP) is well known to be a good candidate for dark matter, and it is also predicted by many new physics models beyond the standard model at the TeV scale. We found that, if the WIMP is a vector particle (spin one particle) which is associated with some gauge symmetry broken at the TeV scale, the higgs mass is often predicted to be 120--125 GeV, which is very consistent with the result of higgs searches recently reported by ATLAS and CMS collaborations at the Large Hadron Collider experiment. In this letter, we consider the vector WIMP using a non-linear sigma model in order to confirm this result as general as possible in a bottom-up approach. Near-future prospects to detect the vector WIMP at both direct and indirect detection experiments of dark matter are also discussed.

  3. Vector financial rogue waves

    Science.gov (United States)

    Yan, Zhenya

    2011-11-01

    The coupled nonlinear volatility and option pricing model presented recently by Ivancevic is investigated, which generates a leverage effect, i.e., stock volatility is (negatively) correlated to stock returns, and can be regarded as a coupled nonlinear wave alternative of the Black-Scholes option pricing model. In this Letter, we analytically propose vector financial rogue waves of the coupled nonlinear volatility and option pricing model without an embedded w-learning. Moreover, we exhibit their dynamical behaviors for chosen different parameters. The vector financial rogue wave (rogon) solutions may be used to describe the possible physical mechanisms for the rogue wave phenomena and to further excite the possibility of relative researches and potential applications of vector rogue waves in the financial markets and other related fields.

  4. Vector WIMP miracle

    Science.gov (United States)

    Abe, Tomohiro; Kakizaki, Mitsuru; Matsumoto, Shigeki; Seto, Osamu

    2012-07-01

    Weakly interacting massive particle (WIMP) is well known to be a good candidate for dark matter, and it is also predicted by many new physics models beyond the standard model at the TeV scale. We found that, if the WIMP is a vector particle (spin-one particle) which is associated with some gauge symmetry broken at the TeV scale, the Higgs mass is often predicted to be 120-125 GeV, which is very consistent with the result of Higgs searches recently reported by ATLAS and CMS Collaborations at the Large Hadron Collider experiment. In this Letter, we consider the vector WIMP using a non-linear sigma model in order to confirm this result as general as possible in a bottom-up approach. Near-future prospects to detect the vector WIMP at both direct and indirect detection experiments of dark matter are also discussed.

  5. Boosting Support Vector Machines

    Directory of Open Access Journals (Sweden)

    Elkin Eduardo García Díaz

    2006-11-01

    Full Text Available En este artículo, se presenta un algoritmo de clasificación binaria basado en Support Vector Machines (Máquinas de Vectores de Soporte que combinado apropiadamente con técnicas de Boosting consigue un mejor desempeño en cuanto a tiempo de entrenamiento y conserva características similares de generalización con un modelo de igual complejidad pero de representación más compacta./ In this paper we present an algorithm of binary classification based on Support Vector Machines. It is combined with a modified Boosting algorithm. It run faster than the original SVM algorithm with a similar generalization error and equal complexity model but it has more compact representation.

  6. Vector WIMP miracle

    International Nuclear Information System (INIS)

    Weakly interacting massive particle (WIMP) is well known to be a good candidate for dark matter, and it is also predicted by many new physics models beyond the standard model at the TeV scale. We found that, if the WIMP is a vector particle (spin-one particle) which is associated with some gauge symmetry broken at the TeV scale, the Higgs mass is often predicted to be 120-125 GeV, which is very consistent with the result of Higgs searches recently reported by ATLAS and CMS Collaborations at the Large Hadron Collider experiment. In this Letter, we consider the vector WIMP using a non-linear sigma model in order to confirm this result as general as possible in a bottom-up approach. Near-future prospects to detect the vector WIMP at both direct and indirect detection experiments of dark matter are also discussed.

  7. Biodegradable Tri-Block Copolymer Poly(lactic acid)-poly(ethylene glycol)-poly(L-lysine)(PLA-PEG-PLL) as a Non-Viral Vector to Enhance Gene Transfection

    OpenAIRE

    Na Zhang; Chunhua Fu; Xiaoli Sun; Donghua Liu; Zaijun Lu; Zhijing Chen

    2011-01-01

    Low cytotoxicity and high gene transfection efficiency are critical issues in designing current non-viral gene delivery vectors. The purpose of the present work was to synthesize the novel biodegradable poly (lactic acid)-poly(ethylene glycol)-poly(L-lysine) (PLA-PEG-PLL) copolymer, and explore its applicability and feasibility as a non-viral vector for gene transport. PLA-PEG-PLL was obtained by the ring-opening polymerization of Lys(Z)-NCA onto amine-terminated NH2-PEG-PLA, then acidolysis ...

  8. Residents’ Awareness of Urban and Social Living Quality: The Example of Prof. Dr. Ahmet Taner Kışlalı Neighborhood in Çayyolu/Ankara

    Directory of Open Access Journals (Sweden)

    Ahmet Tanju Gültekin

    2015-12-01

    Full Text Available Since 1980, the dynamics of globalization have directed the processes of social, cultural, and political adjustment as well as those of economic integration and especially capital towards urban development, forming urban space. The wave of globalization in Turkey, within a process of economic change in the context of neo liberal policies, urban space has been turned into the most profitable area of investment in the unearned income (economic rent sector. The residential sector has been included in this process quickly and easily through effective and widespread marketing strategies. Over the last two decades of this development, the Ankara-Çayyolu District has become segregated economically and socially between its upper and upper-middle class residents in the urban context. This segregation is evident in residential areas with high-level physical and spatial quality. On the other hand, in addition to the measurable physical and spatial standards of housing quality, it is also important to find out if the quality of living meets the social and cultural expectations of its residents. Starting from this point of view, we examine residents’ perceptions of their physical and social environment in our chosen sample area in the Prof. Dr. Ahmet Taner Kışlalı Neighborhood, and their demands and awareness of housing quality. The story of this neighborhood, which begins in 1980, at a time when neo liberal policies and the power to form urban space was all-important, is defined here by the residents’ quality of living and awareness of it. Our results obtained are expected to help guide the creation of liveable housing areas in the future.Keywords: Housing Users, Urban Living Quality, Social Living, Awareness, Ankara- Çayyolu-Prof. Dr. Ahmet Taner Kışlalı Neighborhood.

  9. Redshifts and Killing Vectors

    CERN Document Server

    Harvey, A; Surowitz, E J; Harvey, Alex; Schucking, Engelbert L.; Surowitz, Eugene J.

    2005-01-01

    Courses in introductory special and general relativity have increasingly become part of the curriculum for upper-level undergraduate physics majors and master's degree candidates. One of the topics rarely discussed is symmetry, particularly in the theory of general relativity. The principal tool for its study is the Killing vector. We provide an elementary introduction to the concept of a Killing vector field, its properties, and as an example of its utility apply these ideas to the rigorous determination of gravitational and cosmological redshifts.

  10. Scalar-vector bootstrap

    Science.gov (United States)

    Rejon-Barrera, Fernando; Robbins, Daniel

    2016-01-01

    We work out all of the details required for implementation of the conformal bootstrap program applied to the four-point function of two scalars and two vectors in an abstract conformal field theory in arbitrary dimension. This includes a review of which tensor structures make appearances, a construction of the projectors onto the required mixed symmetry representations, and a computation of the conformal blocks for all possible operators which can be exchanged. These blocks are presented as differential operators acting upon the previously known scalar conformal blocks. Finally, we set up the bootstrap equations which implement crossing symmetry. Special attention is given to the case of conserved vectors, where several simplifications occur.

  11. Matrix vector analysis

    CERN Document Server

    Eisenman, Richard L

    2005-01-01

    This outstanding text and reference applies matrix ideas to vector methods, using physical ideas to illustrate and motivate mathematical concepts but employing a mathematical continuity of development rather than a physical approach. The author, who taught at the U.S. Air Force Academy, dispenses with the artificial barrier between vectors and matrices--and more generally, between pure and applied mathematics.Motivated examples introduce each idea, with interpretations of physical, algebraic, and geometric contexts, in addition to generalizations to theorems that reflect the essential structur

  12. Analysis in Vector Spaces

    CERN Document Server

    Akcoglu, Mustafa A; Ha, Dzung Minh

    2011-01-01

    A rigorous introduction to calculus in vector spaces The concepts and theorems of advanced calculus combined with related computational methods are essential to understanding nearly all areas of quantitative science. Analysis in Vector Spaces presents the central results of this classic subject through rigorous arguments, discussions, and examples. The book aims to cultivate not only knowledge of the major theoretical results, but also the geometric intuition needed for both mathematical problem-solving and modeling in the formal sciences. The authors begin with an outline of key concepts, ter

  13. Sums and Gaussian vectors

    CERN Document Server

    Yurinsky, Vadim Vladimirovich

    1995-01-01

    Surveys the methods currently applied to study sums of infinite-dimensional independent random vectors in situations where their distributions resemble Gaussian laws. Covers probabilities of large deviations, Chebyshev-type inequalities for seminorms of sums, a method of constructing Edgeworth-type expansions, estimates of characteristic functions for random vectors obtained by smooth mappings of infinite-dimensional sums to Euclidean spaces. A self-contained exposition of the modern research apparatus around CLT, the book is accessible to new graduate students, and can be a useful reference for researchers and teachers of the subject.

  14. Vector-borne Infections

    Centers for Disease Control (CDC) Podcasts

    2011-04-18

    This podcast discusses emerging vector-borne pathogens, their role as prominent contributors to emerging infectious diseases, how they're spread, and the ineffectiveness of mosquito control methods.  Created: 4/18/2011 by National Center for Emerging Zoonotic and Infectious Diseases (NCEZID).   Date Released: 4/27/2011.

  15. Calculus with vectors

    CERN Document Server

    Treiman, Jay S

    2014-01-01

    Calculus with Vectors grew out of a strong need for a beginning calculus textbook for undergraduates who intend to pursue careers in STEM. fields. The approach introduces vector-valued functions from the start, emphasizing the connections between one-variable and multi-variable calculus. The text includes early vectors and early transcendentals and includes a rigorous but informal approach to vectors. Examples and focused applications are well presented along with an abundance of motivating exercises. All three-dimensional graphs have rotatable versions included as extra source materials and may be freely downloaded and manipulated with Maple Player; a free Maple Player App is available for the iPad on iTunes. The approaches taken to topics such as the derivation of the derivatives of sine and cosine, the approach to limits, and the use of "tables" of integration have been modified from the standards seen in other textbooks in order to maximize the ease with which students may comprehend the material. Additio...

  16. Noncausal Bayesian Vector Autoregression

    DEFF Research Database (Denmark)

    Lanne, Markku; Luoto, Jani

    We propose a Bayesian inferential procedure for the noncausal vector autoregressive (VAR) model that is capable of capturing nonlinearities and incorporating effects of missing variables. In particular, we devise a fast and reliable posterior simulator that yields the predictive distribution as a...

  17. Random and vector measures

    CERN Document Server

    Rao, M M

    2011-01-01

    The book is devoted to the structural analysis of vector and random (or both) valued countably additive measures, and used for integral representations of random fields. The spaces can be Banach or Frechet types. Several stationary aspects and related processes are analyzed whilst numerous new results are included and many research avenues are opened up.

  18. Vector-borne diseases.

    Science.gov (United States)

    Gubler, D J

    2009-08-01

    Vector-borne diseases have been the scourge of man and animals since the beginning of time. Historically, these are the diseases that caused the great plagues such as the 'Black Death' in Europe in the 14th Century and the epidemics of yellow fever that plagued the development of the New World. Others, such as Nagana, contributed to the lack of development in Africa for many years. At the turn of the 20th Century, vector-borne diseases were among the most serious public and animal health problems in the world. For the most part, these diseases were controlled by the middle of the 20th Century through the application of knowledge about their natural history along with the judicious use of DDT (dichlorodiphenyltrichloroethane) and other residual insecticides to interrupt the transmission cycle between arthropod and vertebrate host. However, this success initiated a period of complacency in the 1960s and 1970s, which resulted in the redirection of resources away from prevention and control of vector-borne diseases. The 1970s was also a time in which there were major changes to public health policy. Global trends, combined with changes in animal husbandry, urbanisation, modern transportation and globalisation, have resulted in a global re-emergence of epidemic vector-borne diseases affecting both humans and animals over the past 30 years. PMID:20128467

  19. Singular Vectors' Subtle Secrets

    Science.gov (United States)

    James, David; Lachance, Michael; Remski, Joan

    2011-01-01

    Social scientists use adjacency tables to discover influence networks within and among groups. Building on work by Moler and Morrison, we use ordered pairs from the components of the first and second singular vectors of adjacency matrices as tools to distinguish these groups and to identify particularly strong or weak individuals.

  20. Emerging Vector-Borne Diseases – Incidence through Vectors

    OpenAIRE

    Savić, Sara; Vidić, Branka; Grgić, Zivoslav; Potkonjak, Aleksandar; Spasojevic, Ljubica

    2014-01-01

    Vector-borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowadays, in intercontinental countries, there is a struggle with emerging diseases, which have found their way to appear through vectors. Vector-borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens, and susceptible human population exist at the same time, at the same pla...

  1. VECTOR BUNDLE, KILLING VECTOR FIELD AND PONTRYAGIN NUMBERS

    Institute of Scientific and Technical Information of China (English)

    周建伟

    1991-01-01

    Let E be a vector bundle over a compact Riemannian manifold M. We construct a natural metric on the bundle space E and discuss the relationship between the killing vector fields of E and M. Then we give a proof of the Bott-Baum-Cheeger Theorem for vector bundle E.

  2. Ankara Kedilerinde (Felis catus angorensis) dış yapı, tüy, büyüme, gelişme ve üreme özellikleri üzerine araştırmalar

    OpenAIRE

    ÖZÇETİN, Sebahattin Tarkan

    2007-01-01

    Ankara Atatürk Orman Çiftliği (A.O.Ç.) Hayvanat Bahçesinde yetiştirilen 5 erkek, 28 dişi ve bu kedilerden doğan 70  yavru  ile  Ankara’nın  çeşitli  semtlerinde  bakılan  11  erkek, 10 dişi, 4 kastre erkek ve 9 steril dişi olmak üzere toplam 137 Ankara Kedisinin kullanıldığı   çalışmada  Ankara Kedisinin dış yapı, tüy, büyüme, gelişme ve üreme özellikleri incelenmiştir. Ankara A.O.Ç. Ha...

  3. On Generalized Vector Equilibrium Problems

    Institute of Scientific and Technical Information of China (English)

    An-hua Wan; Jun-yi Fu; Wei-hua Mao

    2006-01-01

    A new generalized vector equilibrium problem involving set-valued mappings and the proper quasi-concavity of set-valued mappings in topological vector spaces are introduced; its existence theorems and the convexity of the solution sets are established.

  4. Vector mesons in matter

    Indian Academy of Sciences (India)

    Gy Wolf

    2006-04-01

    One consequence of the chiral restoration is the mixing of parity partners. We look for a possible signature of the mixing of vector and axial vector mesons in heavy-ion collisions. We suggest an experimental method for its observation. The dynamical evolution of the heavy-ion collision is described by a transport equation of QMD-type evolving nucleons, * and resonances, ’s and $\\sum$ baryons, and furthermore, ’s, ’s ’s ’s ’s and kaons with their isospin degrees of freedom. The input cross-sections and resonance parameters of the model are fitted to the available nucleon–nucleon and pion–nucleon cross-sections.

  5. Vector fields in cosmology

    CERN Document Server

    Davydov, Evgeny

    2011-01-01

    Vector fields can arise in the cosmological context in different ways, and we discuss both abelian and nonabelian sector. In the abelian sector vector fields of the geometrical origin (from dimensional reduction and Einstein-Eddington modification of gravity) can provide a very non-trivial dynamics, which can be expressed in terms of the effective dilaton-scalar gravity with the specific potential. In the non-abelian sector we investigate the Yang-Mills SU(2) theory which admits isotropic and homogeneous configuration. Provided the non-linear dependence of the lagrangian on the invariant F*F(dual), one can obtain the inflationary regime with the exponential growth of the scale factor. The effective amplitudes of the 'electric' and 'magnetic' components behave like slowly varying scalars at this regime, what allows the consideration of some realistic models with non-linear terms in the Yang-Mills lagrangian.

  6. Vector growth universalities

    International Nuclear Information System (INIS)

    Highlights: ► Joint growth for two or more living beings is addressed in a universality context. ► A vector extension of the growth universalities formalism is fully developed. ► Two useful theorems and the analysis of their implications are presented. ► Insights on the mutual influence between organisms/populations are obtained. - Abstract: A formalism to describe the interactive growth of two or more organisms in a given environment is presented. This is a vector generalization of the scheme developed by Castorina et al. to classify and interpret non-linear ontogenetic growth formulas, which can be applied to such complex self-organizing systems as solid tumors. A theorem that leads to the explicit solutions of the resulting equations is proven. These solutions can describe synergetic, antagonistic, and cooperative growth, and can be applied to both biological and ecological problems.

  7. Electronic structure and nesting-driven enhancement of the RKKY interaction at the magnetic ordering propagation vector in Gd2PdSi3 and Tb2PdSi3

    International Nuclear Information System (INIS)

    We present first-time measurements of the Fermi surface and low-energy electronic structure of intermetallic compounds Gd2PdSi3 and Tb2PdSi3 by means of angle-resolved photoelectron spectroscopy (ARPES). We show that the Fermi surface in both compounds consists of an electron barrel at the Γ point surrounded by spindle-shaped electron pockets originating from the same band, with the band bottom of both features lying at 0.5 eV below the Fermi level. From the experimentally measured band structure, we estimate the momentum-dependent RKKY coupling strength and demonstrate that it is peaked at the 1/2Γ K wave vector. Comparison with neutron diffraction data from the same crystals shows perfect agreement of this vector with the propagation vector of the low-temperature in-plane magnetic order, thereby demonstrating the decisive role of the Fermi surface geometry in explaining the complex magnetically ordered ground state of ternary rare earth silicides.

  8. Vectorization for Java

    OpenAIRE

    Nie, Jiutao; Cheng, Buqi; Li, Shisheng; Wang, Ligang; Li, Xiao-Feng

    2010-01-01

    Java is one of the most popular programming languages in today's software development, but the adoption of Java in some areas like high performance computing, gaming, and media processing is not as universal as in general-purpose computing. A major drawback preventing it from being extensively adopted in those areas is its lower performance than the traditional or domain-specific languages. This paper describes two approaches to improve Java's usability in those areas by introducing vector pr...

  9. Engineering influenza viral vectors

    OpenAIRE

    Li, Junwei; Arévalo, Maria T; Zeng, Mingtao

    2013-01-01

    The influenza virus is a respiratory pathogen with a negative-sense, segmented RNA genome. Construction of recombinant influenza viruses in the laboratory was reported starting in the 1980s. Within a short period of time, pioneer researchers had devised methods that made it possible to construct influenza viral vectors from cDNA plasmid systems. Herein, we discuss the evolution of influenza virus reverse genetics, from helper virus-dependent systems, to helper virus-independent 17-plasmid sys...

  10. Helices and vector bundles

    CERN Document Server

    Rudakov, A N

    1990-01-01

    This volume is devoted to the use of helices as a method for studying exceptional vector bundles, an important and natural concept in algebraic geometry. The work arises out of a series of seminars organised in Moscow by A. N. Rudakov. The first article sets up the general machinery, and later ones explore its use in various contexts. As to be expected, the approach is concrete; the theory is considered for quadrics, ruled surfaces, K3 surfaces and P3(C).

  11. Japanese Encephalitis Vectors

    OpenAIRE

    Wada, Yoshito

    1995-01-01

    On the ecological basis of vector mosquitoes of Japanese encephalitis, measures of their control were examined from viewpoint of their practicability. It was concluded that chemical control is not of practical value, biological control is of limited effectiveness, and environmental control by source reduction is impossible. Instead, it was recommended to improve human living style so as to reduce the frequency of man/mosquito contact.

  12. Interpolation of Vector Measures

    Institute of Scientific and Technical Information of China (English)

    Ricardo del CAMPO; Antonio FERN(A)NDEZ; Fernando MAYORAL; Francisco NARANJO; Enrique A. S(A)NCHEZ-P(E)REZ

    2011-01-01

    Let (Ω, ∑) be a measurable space and m0: ∑→ X0 and m1: ∑ -→ X1 be positive vector measures with values in the Banach K(o)the function spaces X0 and X1. If 0 < α < 1, we define a X10-αXα1 and we analyze the space of integrable functions with respect to measure [m0, m1]α in order to prove suitable extensions of the classical Stein-Weiss formulas that hold for the complex interpolation of Lp-spaces.Since each p-convex order continuous K(o)the function space with weak order unit can be represented as a space of p-integrable functions with respect to a vector measure, we provide in this way a technique to obtain representations of the corresponding complex interpolation spaces. As applications, we provide a Riesz-Thorin theorem for spaces of p-integrable functions with respect to vector measures and a formula for representing the interpolation of the injective tensor product of such spaces.

  13. Ankara Çubuk yöresi turşularından izole edilen laktik asit bakterilerinin bazı teknolojik ve fonksiyonel özelliklerinin belirlenmesi

    OpenAIRE

    ARSLANKOZ, Nurdan

    2011-01-01

          Bu çalışmada, Ankara Çubuk bölgesi turşularından izole edilerek tanımlanması yapılmış ve Ankara Üniversitesi Mühendislik Fakültesi Gıda Mühendisliği Bölümü Kültür Koleksiyonu'nda bulunan 36 adet laktik asit bakterisinin bazı teknolojik ve fonksiyonel özellikleri belirlenmiştir.

    36 adet laktik asit bakterisi suşunun farklı pH ve tuz değerlerinde gelişmesi, laktik asit, H2O2

  14. Ankara Üniversitesi Ziraat Fakültesi yonca ekim alanlarında görülen önemli hastalıkların belirlenmesi

    OpenAIRE

    KARAKAYA, Aziz; ONAR, Mihrace Çiğdem

    2006-01-01

    In this study, important alfalfa diseases occurring in the Ankara University Faculty of Agriculture Haymana and Ayaş Research Farms and Dışkapı Campus were determined. Samples were collected during the years 2003 and 2004 and causal agents of the diseases were identified. The fungi found were: Phoma medicaginis var. medicaginis, Leptotrochila medicaginis, Leveillula taurica, Pseudopeziza medicaginis, Peronospora trifoliorum, Stemphylium botryosum, Stagonospora meliloti, Colletotrichum trifoli...

  15. Leishmaniasis vector behaviour in Kenya

    International Nuclear Information System (INIS)

    Leishmaniasis in Kenya exists in two forms: cutaneous and visceral. The vectors of visceral leishmaniasis have been the subject of investigation by various researchers since World War II, when the outbreak of the disease was first noticed. The vectors of cutaneous leishmaniasis were first worked on only a decade ago after the discovery of the disease focus in Mt. Elgon. The vector behaviour of these diseases, namely Phlebotomus pedifer, the vector of cutaneous leishmaniasis, and Phlebotomus martini, the vector of visceral leishmaniasis, are discussed in detail. P. pedifer has been found to breed and bite inside caves, whereas P. martini mainly bites inside houses. (author)

  16. The Profitability of Animal Husbandry Activities on Farms in Dry Farming Areas and the Interaction between Crop Production and Animal Husbandry: The Case of Ankara Province in Turkey

    Directory of Open Access Journals (Sweden)

    Harun Tanrıvermis

    2007-04-01

    Full Text Available This paper examines the linkages between livestock and crop farming activities and provides a comparative analysis of the profitability of different livestock activities in the highlands of Ankara. The data was collected from 52 sample farms in the Nallıhan, Aya¸s, Güdül and Beypazarı districts of Ankara by way of a questionnaire, where the farms have, on average, 20.7 ha of land and are thus regarded as small family farms. Insufficient irrigated land and working capital, weak market relations and the pressure of high population brings about a requirement to strengthen crop-livestock interaction. Production on the farms is generally carried out in extensive conditions, with goat, sheep and cattle husbandry in addition to crop production. Crop production makes up for 20.8% of the total gross production value on the farms. Of this figure, the entire yields of wheat, barley, pulses, straw and fodder crops are used for own consumption by the households, along with 74% of the wheat and 77% of the barley produced. The research results indicate that the current management systems may be defined as mixed farms in terms of crop–livestock linkages. The average total income of the households surveyed is 9,412.0 USD, of which 63.4% comes from farming activities. Every 1 USD invested in animal husbandry provides an income of 1.12 USD from dairy cattle breeding, 1.13 USD from Angora goat breeding, 1.16 USD from sheep breeding and 1.27 USD from ordinary goat breeding. It has been found that ordinary goat breeding, which provides the greatest relative profitability for the farms, offers many advantages, and that the transition from Angora goat breeding to ordinary goat breeding through the breeding of ordinary male goats into the Angora herd has occurred in recent years. The results of the survey indicate that supporting crop production with animal husbandry is considered a requirement in order to maintain economic and social sustainability in the farms

  17. Scalar - vector soliton fiber lasers

    CERN Document Server

    Wu, Zhichao; Li, Lei; Luo, Yiyang; Tang, Dingyuan; Shen, Deyuan; Tang, Ming; Fu, Songnian; Zhao, Luming

    2016-01-01

    Rapid progress in passively mode-locked fiber lasers is currently driven by the recent discovery of vector feature of mode-locking pulses, namely, the group velocity-locked vector solitons, the phase locked vector solitons, and the high-order vector solitons. Those vector solitons are fundamentally different from the previously known scalar solitons. Here, we report a fiber laser where the mode-locked pulse evolves as a vector soliton in the strong birefringent segment and is transformed into a regular scalar soliton after the polarizer within the laser cavity. The existence of solutions in a polarization-dependent cavity comprising a periodic combination of two distinct nonlinear waves is novel and likely to be applicable to various other nonlinear systems. For very large local birefringence, our laser approaches the working regime of vector soliton lasers, while it approaches scalar soliton fiber lasers under the conditions of very small birefringence.

  18. Optimal Sum-Rate of the Vector Gaussian CEO Problem

    CERN Document Server

    Ekrem, Ersen

    2012-01-01

    We study the vector Gaussian CEO problem, and obtain the optimal sum-rate that attains any given distortion. We show that the evaluation of the Berger-Tung inner bound with jointly Gaussian auxiliary random variables is optimal. We prove this optimality result by using channel enhancement in conjunction with a recent outer bound for the rate-distortion region of the vector Gaussian CEO problem.

  19. Warped Graviton Couplings to Bulk Vectors with Brane Kinetic Terms

    CERN Document Server

    Kobakhidze, Archil; Wu, Lei; Yue, Jason

    2016-01-01

    We consider non-universal couplings between Kaluza-Klein (KK) gravitons and bulk Standard Model (SM) vectors in the Randall-Sundrum (RS) model due to the inclusion of both UV and IR brane-localised gauge kinetic terms. We find that such kinetic terms can enhance the couplings of KK gravitons to SM gauge bosons and help ensure the KK vector masses are consistent with electroweak precision constraints. As an application, we consider the 750 GeV diphoton excess observed in the early LHC Run 2 data, identifying the lightest KK graviton with the diphoton resonance and employing brane kinetic terms to increase the coupling to SM vectors.

  20. Biodegradable Tri-Block Copolymer Poly(lactic acid-poly(ethylene glycol-poly(L-lysine(PLA-PEG-PLL as a Non-Viral Vector to Enhance Gene Transfection

    Directory of Open Access Journals (Sweden)

    Na Zhang

    2011-02-01

    Full Text Available Low cytotoxicity and high gene transfection efficiency are critical issues in designing current non-viral gene delivery vectors. The purpose of the present work was to synthesize the novel biodegradable poly (lactic acid-poly(ethylene glycol-poly(L-lysine (PLA-PEG-PLL copolymer, and explore its applicability and feasibility as a non-viral vector for gene transport. PLA-PEG-PLL was obtained by the ring-opening polymerization of Lys(Z-NCA onto amine-terminated NH2-PEG-PLA, then acidolysis to remove benzyloxycarbonyl. The tri-block copolymer PLA-PEG-PLL combined the characters of cationic polymer PLL, PLA and PEG: the self-assembled nanoparticles (NPs possessed a PEG loop structure to increase the stability, hydrophobic PLA segments as the core, and the primary ε-amine groups of lysine in PLL to electrostatically interact with negatively charged phosphate groups of DNA to deposit with the PLA core. The physicochemical properties (morphology, particle size and surface charge and the biological properties (protection from nuclease degradation, plasma stability, in vitro cytotoxicity, and in vitro transfection ability in HeLa and HepG2 cells of the gene-loaded PLA-PEG-PLL nanoparticles (PLA-PEG-PLL NPs were evaluated, respectively. Agarose gel electrophoresis assay confirmed that the PLA-PEG-PLL NPs could condense DNA thoroughly and protect DNA from nuclease degradation. Initial experiments showed that PLA-PEG-PLL NPs/DNA complexes exhibited almost no toxicity and higher gene expression (up to 21.64% in HepG2 cells and 31.63% in HeLa cells than PEI/DNA complexes (14.01% and 24.22%. These results revealed that the biodegradable tri-block copolymer PLA-PEG-PLL might be a very attractive candidate as a non-viral vector and might alleviate the drawbacks of the conventional cationic vectors/DNA complexes for gene delivery in vivo.

  1. Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants

    DEFF Research Database (Denmark)

    Nielsen, Troels T; Jakobsson, Johan; Rosenqvist, Nina;

    2009-01-01

    BACKGROUND: Lentiviral vectors hold great promise as gene transfer vectors in gene therapeutic settings. However, problems related to the risk of insertional mutagenesis, transgene silencing and positional effects have stalled the use of such vectors in the clinic. Chromatin insulators are boundary...... elements that can prevent enhancer-promoter interactions, if placed between these elements, and protect transgene cassettes from silencing and positional effects. It has been suggested that insulators can improve the safety and performance of lentiviral vectors. Therefore insulators have been incorporated...... into lentiviral vectors in order to enhance their safety profile and improve transgene expression. Commonly such insulator vectors are produced at lower titers than control vectors thus limiting their potential use. RESULTS: In this study we cloned in tandem copies of the chicken beta-globin insulator...

  2. Números, vectores y funciones

    OpenAIRE

    Acevedo Frías, Bernardo; Ospina Arteaga, Omar Evelio

    1992-01-01

    El texto Números, Vectores y Funciones que han elaborado los profesores Asociados Omar Evelio Ospina y Bernardo Acevedo, responden a esta necesidad con sobresalientes cualidades pedagógicas, entre las cuales se destacan el desarrollo detallado de los temas y la proliferación de ejercicios resueltos, lo cual genera un diálogo directo con el lector que puede así aprovechar totalmente su lectura. El material presentado es el fruto de un cuidadoso análisis de los autores, sobre las experiencias d...

  3. Relativistic Rotating Vector Model

    CERN Document Server

    Lyutikov, Maxim

    2016-01-01

    The direction of polarization produced by a moving source rotates with the respect to the rest frame. We show that this effect, induced by pulsar rotation, leads to an important correction to polarization swings within the framework of rotating vector model (RVM); this effect has been missed by previous works. We construct relativistic RVM taking into account finite heights of the emission region that lead to aberration, time-of-travel effects and relativistic rotation of polarization. Polarizations swings at different frequencies can be used, within the assumption of the radius-to-frequency mapping, to infer emission radii and geometry of pulsars.

  4. ANKARA İLİ BİRİNCİ LİG TAKIMLARINDA OYNAYAN BAYAN VOLEYBOLCULARIN BAZI FİZİKSEL VE FİZYOLOJİK PARAMETRELERİNİN İNCELENMESİ / A STUDY ON CERTAIN PHYSICAL AND PHYSIOLOGICAL PARAMETERS OF THE FEMALE VOLLEYBALL PLAYERS IN ANKARA VOLLEYBALL FIRST LEAGUE

    OpenAIRE

    Önder, H. Uğut; ELER, Serdar

    2010-01-01

    Bu çalışmanın amacı, Türkiye Vokybol (I. Lıg) Ankara takımlannda voleyboloynayan toplam 56bayan sporculann bazı fiziksel ve fizyolojik profi ıı erini belirlemek, literaliir çerçevesinde durumtespıtlerinin yapılmasıdır.Deneklerden alınan ölçümler sonucunda şu değerlere ulaşllmıştır.Yaşlar sporcularda 24.21 ± 4.83 yıl,"ücut ağırlığı 68 ± 7.74 kg, dikey sıçrama değeri 47.52 ± 3.89 cm, yatay sıçrama değeri 217.33 &...

  5. Analysis of travel motivations of tourists in terms of their demographical characteristics: The case of AnkaraYabancı turistlerin seyahat motivasyonlarının demografik özellikleri açısından analizi: Ankara örneği

    Directory of Open Access Journals (Sweden)

    İrfan Yazıcıoğlu

    2016-08-01

    Full Text Available The fact that tourists have different desires and expectations and those’ve always changed as well, the studies that focus on understanding the components motivate tourists to buy, have been important more and more. This study aims to reveal travel motivation of foreign tourists who visited Ankara city and to determine if tourists’ motivations vary according to demographical characteristics (gender, marial status, income, education, employment, age, nationality. As an implementation area for this study; Ankara is chosen and 390 foreign tourists visiting Ankara are applied. As data collection instrument, survey forms are used within the scope of this study and in analysis of collected data, t test and Anova are used.  As a result of the analyses done; it is determined that their common motivations show a significant difference according to their gender and nationality, but doesn’t show a significant difference according to their marial status, income, education, employment, age. When it is analyzed in terms of dimensions;  it is determined that the motivations of “knowledge” and “relaxation” show a significant difference according to their gender and nationality;  the motivation of “entertainment” shows a significant difference according to their gender, marial status, income, employment, and finally the motivation of “prestige” shows only a significant difference according to their nationality.   Özet Turistlerin farklı istek ve beklentilere sahip olmaları ve bu isteklerin sürekli değişmesi nedeniyle turistleri satın almaya motive eden unsurları anlamaya yönelik çalışmalar önem kazanmıştır. Bu araştırmanın amacı, yabancı turistlerin seyahat motivasyonlarının belirlenmesi ve seyahat motivasyonlarının demografik özelliklere (cinsiyet, medeni durum, gelir, eğitim, çalışma durumu, yaş ve milliyet göre farklılık gösterip göstermediğinin ortaya konmasıdır. Bu amaç do

  6. ANKARA HAYMANA TÜRKŞEREFLİ GÖLETİ SULAMA ALANINDAKİ TOPRAKLARIN SULAMA PARAMETRELERİ VE TUZLULUK YÖNÜNDEN İNCELENMESİ

    OpenAIRE

    ANLIATAMER, Eser

    2007-01-01

    Bu çalışmada Devlet Su İşleri (DSİ) tarafından yapılması planlanan Ankara-Haymana-Türkşerefli Göleti sulama alanının yıllar içerisinde değişim gösteren tuzluluk durumu araştırılmıştır. Bu bağlamda 1998 yılı ile 2006 yılı toprak ve su örneklerinde gerekli olan değerleri karşılaştırılmıştır. 8 yıllık süre içinde 49 ha alanın 1. sınıf limitten (EC:2-4 dS/m) 2. sınıf (EC:4-8 dS/m) tuzluluk limitine; 77 ha alanın 1. sınıf limitlerden (EC:2-4 dS/m) 3. Sınıf (EC:8-12 dS/m) limitlere; 221 ha alanın b...

  7. Mucosal immunization with PLGA-microencapsulated DNA primes a SIV-specific CTL response revealed by boosting with cognate recombinant modified vaccinia virus Ankara

    International Nuclear Information System (INIS)

    Systemically administered DNA encoding a recombinant human immunodeficiency virus (HIV) derived immunogen effectively primes a cytotoxic T lymphocyte (CTL) response in macaques. In this further pilot study we have evaluated mucosal delivery of DNA as an alternative priming strategy. Plasmid DNA, pTH.HW, encoding a multi-CTL epitope gene, was incorporated into poly(D,L-lactic-co-glycolic acid) microparticles of less than 10 μm in diameter. Five intrarectal immunizations failed to stimulate a circulating vaccine-specific CTL response in 2 Mamu-A*01+ rhesus macaques. However, 1 week after intradermal immunization with a cognate modified vaccinia virus Ankara vaccine MVA.HW, CTL responses were detected in both animals that persisted until analysis postmortem, 12 weeks after the final boost. In contrast, a weaker and less durable response was seen in an animal vaccinated with the MVA construct alone. Analysis of lymphoid tissues revealed a disseminated CTL response in peripheral and regional lymph nodes but not the spleen of both mucosally primed animals

  8. Kesikköprü (Ankara) baraj gölündeki bentik organizma türleri ve mevsimsel değişimleri

    OpenAIRE

    AHISKA, Seyhan

    1999-01-01

       Nisan 1995 - Mayıs 1996 tarihleri arasında Kesiköprü Baraj Gölü (Ankara) 'nde yapılan bu çalışmada, bentik fauna, biyomas değerleri ve mevsimsel değişimler, gölün bazı fiziksel ve kimyasal özellikleri ile birlikte araştırılmıştır. Göldeki bentik faunanın sayısal olarak % 26,88 'ini Chironomidae larvaları, % 32,59' unu Oligochaeta türü ve % 40,5 'ini diğer bentik omurgasız gruplarının oluşturduğu saptanmıştır. Bentik faunanın yaş ağırlığı yıllık orta l...

  9. The Mediating Role of Job Stress on The Effect of Mobbing on Burnout: An Analysis of Social Security Organization Employees in The District of Ankara

    Directory of Open Access Journals (Sweden)

    Yücel Erol

    2015-06-01

    Full Text Available In this study, due to the influence of Mobbing (MO on Burnout (BU, the mediating role of Job Stress (JS on employees is examined. Hence, 826 employees of public and private institutions in Ankara were included in the sample. The data obtained by a questionnaire that prepared by Leymann (1996’s MO scale, and Maslach (1981's BU scale and Haynes (1996's JS scale. Data was evaluated by using One-Way ANOVA, correlation, regression, and multiple regression SPSS. As can be seen from the results of research, applied and perceived MO has a significant impact on employees' JS’s levels and becomes effective in the creation of JS. On the other hand, BU syndrome were seen as a consequence of the resulting JS. These conditions affect each other and existence of one within the organizational structure, results emergence of the other two. Therefore, management of organization, all levels of managers, and employees as individuals should be aware of these psychological states and conduct studies aimed for its prevention.In this research, meaningful relationships have been identified in the mediating role of JS at the impact of MO on BU. On the other hand in terms of demographic variables, significant variations were found in the levels of MO, BU, and JS

  10. FAMILY-WORK CONFLICT AND LIFE SATISFACTION AMONG WORKERS OF ANKARA YOUTH SERVICES AND PROVINCIAL DIRECTORATE OF SPORTS ACCORDING TO DIFFERENT VARIABLES

    Directory of Open Access Journals (Sweden)

    Mustafa Önder

    2016-04-01

    Full Text Available In this study Work-Family Conflict, Family-Work Conflict and Life Satisfaction were carried out to indicate 329 staff’s relationship between each other, who work in Ankara Youth Services and Sports Province Management, by determining whether work-family conflict, family-work conflict and life satisfaction differientiate or not according to socio-demographic variables. According to obtained results, it was concluded that gender, age, having management position, number of children and duration of experience in job were not significant on family-work conflict, work-family conflict and life satisfaction. On the other hand married staff compared to single ones and staff whose spouse works, experienced the work- family conflict more. Moreover, it was deduced that education level and income level were significant on life satisfaction. Furthermore, a positive way medium level relationship between family- work conflict and work- family conflict was found out supporting the obtained data that staff who has high level of family- work conflict will have relationship between life satisfaction and between family- work conflict / work- family conflict was statistically meaningless.

  11. On Killing vectors and harmonic vectors at quantization of gravitation

    International Nuclear Information System (INIS)

    Attention is paid to two shortcomings occuring at quantization in the curved spacetime: mathematical shortcoming consisting in the killing vector absence in arbitrary Riemann space and physical one consisting in absence of energy-momentum tensor of the gravitational field. It is shown, that both shortcomings may be removed, if the killing vectors are replaced by harmonic vectors corresponding to shift generators of the Poincare group existing in arbitrary Riemann space

  12. Photoinduced Magnetic Nanoprobe Excited by Azimuthally Polarized Vector Beam

    CERN Document Server

    Guclu, Caner; Capolino, Filippo

    2016-01-01

    The concept of magnetic nanoprobes (or magnetic nanoantennas) providing a magnetic near-field enhancement and vanishing electric field is presented and investigated, together with their excitation. It is established that a particular type of cylindrical vector beams called azimuthally electric polarized vector beams yield strong longitudinal magnetic field on the beam axis where the electric field is ideally null. These beams with an electric polarization vortex and cylindrical symmetry are important in generating high magnetic to electric field contrast, i.e., large local field admittance, and in allowing selective excitation of magnetic transitions in matter located on the beam axis. We demonstrate that azimuthally polarized vector beam excitation of a photoinduced magnetic nanoprobe made of a magnetically polarizable nano cluster leads to enhanced magnetic near field with resolution beyond diffraction limit. We introduce two figures of merit as magnetic field enhancement and local field admittance normaliz...

  13. Percutaneous Vaccination as an Effective Method of Delivery of MVA and MVA-Vectored Vaccines.

    Directory of Open Access Journals (Sweden)

    Clement A Meseda

    Full Text Available The robustness of immune responses to an antigen could be dictated by the route of vaccine inoculation. Traditional smallpox vaccines, essentially vaccinia virus strains, that were used in the eradication of smallpox were administered by percutaneous inoculation (skin scarification. The modified vaccinia virus Ankara is licensed as a smallpox vaccine in Europe and Canada and currently undergoing clinical development in the United States. MVA is also being investigated as a vector for the delivery of heterologous genes for prophylactic or therapeutic immunization. Since MVA is replication-deficient, MVA and MVA-vectored vaccines are often inoculated through the intramuscular, intradermal or subcutaneous routes. Vaccine inoculation via the intramuscular, intradermal or subcutaneous routes requires the use of injection needles, and an estimated 10 to 20% of the population of the United States has needle phobia. Following an observation in our laboratory that a replication-deficient recombinant vaccinia virus derived from the New York City Board of Health strain elicited protective immune responses in a mouse model upon inoculation by tail scarification, we investigated whether MVA and MVA recombinants can elicit protective responses following percutaneous administration in mouse models. Our data suggest that MVA administered by percutaneous inoculation, elicited vaccinia-specific antibody responses, and protected mice from lethal vaccinia virus challenge, at levels comparable to or better than subcutaneous or intramuscular inoculation. High titers of specific neutralizing antibodies were elicited in mice inoculated with a recombinant MVA expressing the herpes simplex type 2 glycoprotein D after scarification. Similarly, a recombinant MVA expressing the hemagglutinin of attenuated influenza virus rgA/Viet Nam/1203/2004 (H5N1 elicited protective immune responses when administered at low doses by scarification. Taken together, our data suggest that

  14. Extended vector-tensor theories

    CERN Document Server

    Kimura, Rampei; Yoshida, Daisuke

    2016-01-01

    Recently, several extensions of massive vector theory in curved space-time have been proposed in many literatures. In this paper, we consider the most general vector-tensor theories that contain up to two derivatives with respect to metric and vector field. By imposing a degeneracy condition of the Lagrangian in the context of ADM decomposition of space-time to eliminate an unwanted mode, we construct a new class of massive vector theories where five degrees of freedom can propagate, corresponding to three for massive vector modes and two for massless tensor modes. We find that the generalized Proca and the beyond generalized Proca theories up to the quartic Lagrangian, which should be included in this formulation, are degenerate theories even in curved space-time. Finally, introducing new metric and vector field transformations, we investigate the properties of thus obtained theories under such transformations.

  15. Semitopological Vector Spaces and Hyperseminorms

    Directory of Open Access Journals (Sweden)

    Mark Burgin

    2013-11-01

    Full Text Available In this paper, we introduce and study semitopological vector spaces. The goal is to provide an efficient base for developing the theory of extrafunction spaces in an abstract setting of algebraic systems and topological spaces. Semitopological vector spaces are more general than conventional topological vector spaces, which proved to be very useful for solving many problems in functional analysis. To study semitopological vector spaces, hypermetrics and hyperpseudometrics are introduced and it is demonstrated that hyperseminorms, studied in previous works of the author, induce hyperpseudometrics, while hypernorms induce hypermetrics. Sufficient and necessary conditions for a hyperpseudometric (hypermetric to be induced by a hyperseminorm (hypernorm are found. We also show that semitopological vector spaces are closely related to systems of hyperseminorms. Then defining boundedness and continuity relative to associated systems of hyperseminorms, we study relations between relative boundedness and relative continuity for mappings of vector spaces with systems of hyperseminorms and systems of hypernorms.

  16. Optimality Conditions in Vector Optimization

    CERN Document Server

    Jiménez, Manuel Arana; Lizana, Antonio Rufián

    2011-01-01

    Vector optimization is continuously needed in several science fields, particularly in economy, business, engineering, physics and mathematics. The evolution of these fields depends, in part, on the improvements in vector optimization in mathematical programming. The aim of this Ebook is to present the latest developments in vector optimization. The contributions have been written by some of the most eminent researchers in this field of mathematical programming. The Ebook is considered essential for researchers and students in this field.

  17. Integrating vector control across diseases

    OpenAIRE

    Golding, N.; Wilson, AL; Moyes, CL; Cano, J.; Pigott, DM; Velayudhan, R; Brooker, SJ; Smith, DL; Hay, SI; Lindsay, SW

    2015-01-01

    Background Vector-borne diseases cause a significant proportion of the overall burden of disease across the globe, accounting for over 10 % of the burden of infectious diseases. Despite the availability of effective interventions for many of these diseases, a lack of resources prevents their effective control. Many existing vector control interventions are known to be effective against multiple diseases, so combining vector control programmes to simultaneously tackle several diseases could of...

  18. Multiscale hierarchical support vector clustering

    Science.gov (United States)

    Hansen, Michael Saas; Holm, David Alberg; Sjöstrand, Karl; Ley, Carsten Dan; Rowland, Ian John; Larsen, Rasmus

    2008-03-01

    Clustering is the preferred choice of method in many applications, and support vector clustering (SVC) has proven efficient for clustering noisy and high-dimensional data sets. A method for multiscale support vector clustering is demonstrated, using the recently emerged method for fast calculation of the entire regularization path of the support vector domain description. The method is illustrated on artificially generated examples, and applied for detecting blood vessels from high resolution time series of magnetic resonance imaging data. The obtained results are robust while the need for parameter estimation is reduced, compared to support vector clustering.

  19. Localization and vector spherical harmonics

    Science.gov (United States)

    von Brecht, James H.

    2016-01-01

    This paper establishes the following localization property for vector spherical harmonics: a wide class of non-local, vector-valued operators reduce to local, multiplication-type operations when applied to a vector spherical harmonic. As localization occurs in a very precise, quantifiable and explicitly computable fashion, the localization property provides a set of useful formulae for analyzing vector-valued fractional diffusion and non-local differential equations defined on S d - 1. As such analyses require a detailed understanding of operators for which localization occurs, we provide several applications of the result in the context of non-local differential equations.

  20. Multistage vector (MSV) therapeutics.

    Science.gov (United States)

    Wolfram, Joy; Shen, Haifa; Ferrari, Mauro

    2015-12-10

    One of the greatest challenges in the field of medicine is obtaining controlled distribution of systemically administered therapeutic agents within the body. Indeed, biological barriers such as physical compartmentalization, pressure gradients, and excretion pathways adversely affect localized delivery of drugs to pathological tissue. The diverse nature of these barriers requires the use of multifunctional drug delivery vehicles that can overcome a wide range of sequential obstacles. In this review, we explore the role of multifunctionality in nanomedicine by primarily focusing on multistage vectors (MSVs). The MSV is an example of a promising therapeutic platform that incorporates several components, including a microparticle, nanoparticles, and small molecules. In particular, these components are activated in a sequential manner in order to successively address transport barriers. PMID:26264836

  1. Resonance vector mode locking

    CERN Document Server

    Kolpakov, Stanislav A; Loika, Yuri; Tarasov, Nikita; Kalashnikov, Vladimir; Agrawal, Govind P

    2015-01-01

    A mode locked fibre laser as a source of ultra-stable pulse train has revolutionised a wide range of fundamental and applied research areas by offering high peak powers, high repetition rates, femtosecond range pulse widths and a narrow linewidth. However, further progress in linewidth narrowing seems to be limited by the complexity of the carrier-envelope phase control. Here for the first time we demonstrate experimentally and theoretically a new mechanism of resonance vector self-mode locking where tuning in-cavity birefringence leads to excitation of the longitudinal modes sidebands accompanied by the resonance phase locking of sidebands with the adjacent longitudinal modes. An additional resonance with acoustic phonons provides the repetition rate tunability and linewidth narrowing down to Hz range that drastically reduces the complexity of the carrier-envelope phase control and so will open the way to advance lasers in the context of applications in metrology, spectroscopy, microwave photonics, astronomy...

  2. Estimation of vector velocity

    DEFF Research Database (Denmark)

    2000-01-01

    Using a pulsed ultrasound field, the two-dimensional velocity vector can be determined with the invention. The method uses a transversally modulated ultrasound field for probing the moving medium under investigation. A modified autocorrelation approach is used in the velocity estimation. The new...... estimator automatically compensates for the axial velocity, when determining the transverse velocity by using fourth order moments rather than second order moments. The estimation is optimized by using a lag different from one in the estimation process, and noise artifacts are reduced by using averaging of...... RF samples. Further, compensation for the axial velocity can be introduced, and the velocity estimation is done at a fixed depth in tissue to reduce spatial velocity dispersion....

  3. The MSFC Vector Magnetograph

    Science.gov (United States)

    Hagyard, M. J.; Cumings, N. P.; West, E. A.; Smith, J. E.

    1982-09-01

    The NASA/Marshall Space Flight Center's solar vector magnetograph system is described; this system allows measurements of all components of the Sun's photospheric magnetic field over a 5 × 5 or 2.0 × 2.0 arc min square field-of-view with an optimum time resolution of ˜ 100 s and an optimum signal-to-noise of ˜1600. The basic system components are described, including the optics, detector, digital system and associated electronics. Automatic sequencing and control functions are outlined as well as manual selections of system parameters which afford unique system flexibility. Results of system calibration and performance are presented, including linearity, dynamic range, uniformity, spatial and spectral resolutions, signal-to-noise, electro-optical retardation and polarization calibration. Scientific investigations which utilize the unique characteristics of the instrument are described and typical results are presented.

  4. Vector-Tensor and Vector-Vector Decay Amplitude Analysis of B0->phi K*0

    CERN Document Server

    Aubert, B; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, R; Allen, M T; Allison, J; Altenburg, D D; Andreotti, M; Angelini, C; Anulli, F; Arnaud, N; Asgeirsson, D J; Aston, D; Azzolini, V; Baak, M A; Back, J J; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Bard, D J; Barlow, N R; Barlow, R J; Barrett, M; Bartoldus, R; Batignani, G; Battaglia, M; Bauer, J M; Bechtle, P; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Benelli, G; Berger, N; Bernard, D; Berryhill, J W; Best, D S; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bhuyan, B; Bianchi, F; Biasini, M; Biesiada, J; Blanc, F; Blaylock, G; Blinov, V E; Bloom, P C; Blount, N L; Bomben, M; Bondioli, M; Bonneaud, G R; Bosisio, L; Boutigny, D; Bowerman, D A; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, J E; Briand, H; Brown, C M; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchanan, C; Bugg, W; Bukin, A D; Bula, R; Burchat, P R; Burke, J P; Button-Shafer, J; Buzzo, A; Bóna, M; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Cenci, R; Chai, X; Chaisanguanthum, K S; Chao, M; Charles, E; Charles, M J; Chauveau, J; Chavez, C A; Chen, A; Chen, C; Chen, E; Chen, J C; Chen, S; Chen, X; Chen, X R; Cheng, B; Cheng, C H; Chia, Y M; Cibinetto, G; Clark, P J; Clarke, C K; Claus, R; Cochran, J; Coleman, J P; Contri, R; Convery, M R; Corwin, L A; Cossutti, F; Cottingham, W N; Couderc, F; Covarelli, R; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L; Cunha, A; Curry, S; Côté, D; D'Orazio, A; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, C L; De Nardo, Gallieno; De Sangro, R; Del Amo-Sánchez, P; Del Buono, L; Del Re, D; Della Ricca, G; Denig, A G; Di Lodovico, F; Di Marco, E; Dingfelder, J C; Dittongo, S; Dong, L; Dorfan, J; Druzhinin, V P; Dubitzky, R S; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Ebert, M; Eckhart, E A; Eckmann, R; Edgar, C L; Edwards, A J; Egede, U; Eigen, G; Eisner, A M; Elmer, P; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Eyges, V; Fabozzi, F; Faccini, R; Fang, F; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flacco, C J; Flack, R L; Flächer, H U; Flood, K T; Ford, K E; Ford, W T; Forster, I J; Forti, F; Fortin, D; Foulkes, S D; Franek, B; Frey, R; Fritsch, M; Fry, J R; Fulsom, B G; Gabathuler, E; Gaidot, A; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gao, Y; Gary, J W; Gaspero, M; Gatto, C; Gaz, A; George, K A; Gill, M S; Giorgi, M A; Gladney, L; Glanzman, T; Godang, R; Golubev, V B; Gowdy, S J; Gradl, W; Graham, M T; Graugès-Pous, E; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Z J; Hadavand, H K; Haire, M; Halyo, V; Hamano, K; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, A J; Hartfiel, B L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hill, E J; Hirschauer, J F; Hitlin, D G; Hollar, J J; Hong, T M; Honscheid, K; Hopkins, D A; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Hutchcroft, D E; Höcker, A; Igonkina, O; Innes, W R; Izen, J M; Jackson, P D; Jackson, P S; Jacobsen, R G; Jain, V; Jasper, H; Jawahery, A; Jessop, C P; Judd, D; Kadyk, J A; Kagan, H; Karyotakis, Yu; Kass, R; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Klose, V; Knecht, N S; Koch, H; Kolb, J A; Kolomensky, Yu G; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kreisel, A; Krishnamurthy, M; Kroeger, R; Kroseberg, J; Kukartsev, G; Kutter, P E; Kyberd, P; La Vaissière, C de; Lacker, H M; Lae, C K; Lafferty, G D; Lanceri, L; Lange, D J; Lankford, A J; Latham, T E; Latour, E; Lau, Y P; Lazzaro, A; Le Diberder, F R; Lee, C L; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Lewandowski, B; Li Gioi, L; Li, S; Li, X; Lista, L; Liu, H; Lo Vetere, M; LoSecco, J M; Lockman, W S; Lombardo, V; Long, O; Lopes-Pegna, D; Lopez-March, N; Lou, X C; Lu, M; Luitz, S; Lund, P; Luppi, E; Lusiani, A; Lutz, A M; Lynch, G; Lynch, H L; Lü, C; Lüth, V; MacFarlane, D B; Macri, M M; Mader, W F; Majewski, S A; Malcles, J; Mallik, U; Mancinelli, G; Mandelkern, M A; Marchiori, G; Margoni, M; Marks, J; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Mclachlin, S E; Meadows, B T; Mellado, B; Menges, W; Merkel, J; Messner, R; Meyer, N T; Meyer, W T; Mihályi, A; Mir, L M; Mishra, K; Mohanty, G B; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morganti, M; Morganti, S; Morii, M; Muheim, F; Müller, D R; Nagel, M; Naisbit, M T; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nesom, G; Nicholson, H; Nikolich, M B; Nogowski, R; Nugent, I M; O'Grady, C P; Ocariz, J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Oyanguren, A; Ozcan, V E; Paar, H P; Pacetti, S; Palano, A; Palombo, F; Pan, B; Pan, Y; Panduro, W; Paoloni, E; Paolucci, P; Pappagallo, M; Park, W; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, I M; Peters, K; Petersen, B A; Petrella, A; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Piredda, G; Playfer, S; Poireau, V; Polci, F; Pompili, A; Porter, F C; Posocco, M; Potter, C T; Prell, S; Prencipe, E; Prepost, R; Pripstein, M; Pruvot, S; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rahmat, R; Rama, M; Ratcliff, B N; Raven, G; Regensburger, J J; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roberts, D A; Robertson, A I; Robertson, S H; Robutti, E; Rodier, S; Roe, N A; Ronan, M T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Roudeau, P; Rubin, A E; Ruddick, W O; Röthel, W; Sacco, R; Saeed, M A; Safai-Tehrani, F; Saleem, M; Salnikov, A A; Salvatore, F; Sanders, D A; Santroni, A; Saremi, S; Satpathy, A; Schalk, T; Schenk, S; Schilling, C J; Schindler, R H; Schofield, K C; Schott, G; Schröder, T; Schröder, H; Schubert, J; Schubert, K R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Serrano, J; Sharma, V; Shen, B C; Sherwood, D J; Simard, M; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Smith, A J S; Smith, J G; Snoek, H L; Snyder, A; Sobie, R J; Soffer, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spitznagel, M; Spradlin, P; Steinke, M; Stelzer, J; Stocchi, A; Stoker, D P; Stroili, R; Strom, D; Strube, J; Stugu, B; Stängle, H; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; Suzuki, K; Swain, S K; Taras, P; Taylor, F; Telnov, A V; Teodorescu, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thompson, J M; Tisserand, V; Todyshev, Y K; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Ulmer, K A; Uwer, U; Van Bakel, N; Vasseur, G; Vavra, J; Vazquez, A; Verderi, M; Viaud, F B; Vitale, L; Voci, C; Voena, C; Volk, A; Wagner, A P; Wagner, S R; Wagoner, D E; Waldi, R; Walker, D; Walsh, J J; Wang, K; Wang, P; Wang, W F; Wappler, F R; Watson, A T; Weaver, M; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Wilson, F F; Wilson, J R; Wilson, M G; Wilson, R J; Winklmeier, F; Wisniewski, W J; Wittgen, M; Wong, Q K; Wormser, G; Wren, A C; Wright, D H; Wright, D M; Wu, J; Wu, S L; Wulsin, H W; Xie, Y; Yamamoto, R K; Yarritu, A K; Ye, S; Yi, J I; Yi, K; Young, C C; Yu, Z; Yéche, C; Zain, S B; Zallo, A; Zeng, Q; Zghiche, A; Zhang, J; Zhang, L; Zhao, H W; Zhu, Y S; Ziegler, V; Zito, M; Çuhadar-Dönszelmann, T; al, et

    2007-01-01

    We perform an amplitude analysis of the decays B0->phi K^*_2(1430)0, phi K^*(892)0, and phi(K pi)^0_S-wave with a sample of about 384 million BBbar pairs recorded with the BABAR detector. The fractions of longitudinal polarization f_L of the vector-tensor and vector-vector decay modes are measured to be 0.853 +0.061-0.069 +-0.036 and 0.506 +-0.040 +-0.015, respectively. Overall, twelve parameters are measured for the vector-vector decay and seven parameters for the vector-tensor decay, including the branching fractions and parameters sensitive to CP-violation.

  5. Estimation of Motion Vector Fields

    DEFF Research Database (Denmark)

    Larsen, Rasmus

    1993-01-01

    This paper presents an approach to the estimation of 2-D motion vector fields from time varying image sequences. We use a piecewise smooth model based on coupled vector/binary Markov random fields. We find the maximum a posteriori solution by simulated annealing. The algorithm generate sample...

  6. The vector resultant phase shifter

    International Nuclear Information System (INIS)

    A new type of voltage controlled phase shifter developed by HIRFL laboratory is better than mechanical phase shifter in all respects of performance, price, and reliability. It's principle is based on vector composition, so this new phase shifter is called vector resultant voltage controlled phase shifter. This new phase shifter has been applied in HIRFL phase stabilization system and satisfactory result has been obtained

  7. Vectors on the Basketball Court

    Science.gov (United States)

    Bergman, Daniel

    2010-01-01

    An Idea Bank published in the April/May 2009 issue of "The Science Teacher" describes an experiential physics lesson on vectors and vector addition (Brown 2009). Like its football predecessor, the basketball-based investigation presented in this Idea Bank addresses National Science Education Standards Content B, Physical Science, 9-12 (NRC 1996)…

  8. Rice Reoviruses in Insect Vectors.

    Science.gov (United States)

    Wei, Taiyun; Li, Yi

    2016-08-01

    Rice reoviruses, transmitted by leafhopper or planthopper vectors in a persistent propagative manner, seriously threaten the stability of rice production in Asia. Understanding the mechanisms that enable viral transmission by insect vectors is a key to controlling these viral diseases. This review describes current understanding of replication cycles of rice reoviruses in vector cell lines, transmission barriers, and molecular determinants of vector competence and persistent infection. Despite recent breakthroughs, such as the discoveries of actin-based tubule motility exploited by viruses to overcome transmission barriers and mutually beneficial relationships between viruses and bacterial symbionts, there are still many gaps in our knowledge of transmission mechanisms. Advances in genome sequencing, reverse genetics systems, and molecular technologies will help to address these problems. Investigating the multiple interaction systems among the virus, insect vector, insect symbiont, and plant during natural infection in the field is a central topic for future research on rice reoviruses. PMID:27296147

  9. Vector superconductivity in cosmic strings

    International Nuclear Information System (INIS)

    We argue that in most realistic cases, the usual Witten-type bosonic superconductivity of the cosmic string is automatically (independent of the existence of superconducting currents) accompanied by the condensation of charged gauge vector bosons in the core giving rise to a new vector type superconductivity. The value of the charged vector condensate is related with the charged scalar expectation value, and vanishes only if the latter goes to zero. The mechanism for the proposed vector superconductivity, differing fundamentally from those in the literature, is delineated using the simplest realistic example of the two Higgs doublet standard model interacting with the extra cosmic string. It is shown that for a wide range of parameters, for which the string becomes scalarly superconducting, W boson condensates (the sources of vector superconductivity) are necessarily excited. (author). 14 refs

  10. Evaluation of DNA Damage in Common Carp (Cyprinus carpio L. by Comet Assay for Determination of Possible Pollution in Lake Mogan (Ankara

    Directory of Open Access Journals (Sweden)

    İsmet Çok

    2011-01-01

    Full Text Available Contamination of the aquatic environment with various concentrations of pollutants results in unexpected threats to humans and wildlife. The consequences of exposure and metabolism of pollutants/xenobiotics, especially carcinogens and mutagens, can be suitably assessed by investigating severe events, such as DNA damage; for example, DNA adducts and DNA strand breaks. One of the commonly used techniques to detect DNA damage in aquatic organisms is single-cell gel electrophoresis (comet assay. This study was carried out using Cyprinus carpio in order to identify the possible pollution in Lake Mogan, near Ankara, Turkey, where the city's sewer system and pesticides used in agriculture are believed to be the common causes of pollution. From the comet assay, the tail length (μm, tail intensity (%, and tail moment values of fish caught from Lake Mogan were found to be 31.10 ± 10.39, 7.77 ± 4.51, 1.50 ± 1.48, respectively, whereas for clean reference sites they were found to be 22.80 ± 1.08, 3.47 ± 1.59, 0.40 ± 0.51, respectively. The values are statistically different from each other (p < 0.0001, p < 0.0001, and p < 0.0013, respectively. These results indicate that Lake Mogan may be polluted with substances that have genotoxic effects and constitute an early warning for the lake system. Further detailed research is needed to establish the source of the pollution and the chemicals responsible.

  11. An evaluation of the attributes of a political product (political leader by young voters: A research on the students at the universities in Ankara

    Directory of Open Access Journals (Sweden)

    Cihat Polat

    2008-01-01

    Full Text Available In democratic countries, the way of a political party to get in depends on convincing adequate number of voters to politically buy its political product package presented in political market during the election campaign. Political leader is assumed to be one of the most important –even the most important- components of the political product package almost in all over the world. Thence, political leader has a considerable significance in the entire political package of a party and the characteristics of him/her are the primary determinant of the quality of it.Especially in the markets as in Turkey that votes mostly tend to cluster considering the characteristics of the political leader, the mentioned characteristics play an important role in voting decision process. Though the proportion of university students to total number of voters in Turkish political market is not so much, the market is mostly composed of young voters. Nonetheless, as university students compose of the highest-educated proportion of total voters, they relatively have great potential as a pressure group in respect of affecting political decisions and being an opinion of policy. In consequence, it may be assumed that this group has a specific political weight. To be aware of the characteristics that university students seek in a political leader is a topic of interest in both political practices and political marketing theory. This study presents the results of a survey conducted on a sample of 500 students educating in different universities in Ankara. The survey aims to find out the desired characteristics of a political leader in the eyes of university students and to rank them in a known set according to their importance levels. The findings of the study seem to be interesting in scope of both political parties and field of political marketing.

  12. Environmental Harmony and Evaluation of Advertisement Billboards with Digital Photogrammetry Technique and GIS Capabilities: A Case Study in the City of Ankara

    Science.gov (United States)

    Aydın, Cevdet C.; Nişancı, Recep

    2008-01-01

    Geographical Information Systems (GIS) have been gaining a growing interest in Turkey. Many local governments and public agencies have been struggling to set up such systems to serve the needs and meet public requirements. Urban life shelters the advertisement reality which is presented at various places, on vehicles, shops etc. in daily life. It can be said that advertisement is a part of daily life in urban area, especially in city centers. In addition, one of the main sources of revenue for municipalities comes from advertising and notices. The advertising sector provides a great level of income today. Therefore advertising is individually very important for local governments and urban management. Although it is valuable for local governments, it is also very important for urban management to place these advertisement signs and billboards in an orderly fashion which is pleasing to the eye. Another point related to this subject is the systematic control mechanism which is necessary for collecting taxes regularly and updating. In this paper, first practical meaning of notice and advertisement subject, problem definition and objectives are described and then legal support and daily practice are revised. Current practice and problems are mentioned. Possibilities of measuring and obtaining necessary information by using digital images and transferring them to spatial databases are studied. By this study, a modern approach was developed for urban management and municipalities by using information technology which is an alternative to current application. Criteria which provide environmental harmony such as urban beauty, colour, compatibility and safety were also evaluated. It was finally concluded that measuring commercial signs and keeping environmental harmony under control for urban beauty can be provided by Digital Photogrammetry (DP) technique and GIS capabilities which were studied with pilot applications in the city center of Ankara.

  13. Environmental Harmony and Evaluation of Advertisement Billboards with Digital Photogrammetry Technique and GIS Capabilities: A Case Study in the City of Ankara

    Directory of Open Access Journals (Sweden)

    Recep Nisancı

    2008-05-01

    Full Text Available Geographical Information Systems (GIS have been gaining a growing interest in Turkey. Many local governments and public agencies have been struggling to set up such systems to serve the needs and meet public requirements. Urban life shelters the advertisement reality which is presented at various places, on vehicles, shops etc. in daily life. It can be said that advertisement is a part of daily life in urban area, especially in city centers. In addition, one of the main sources of revenue for municipalities comes from advertising and notices. The advertising sector provides a great level of income today. Therefore advertising is individually very important for local governments and urban management. Although it is valuable for local governments, it is also very important for urban management to place these advertisement signs and billboards in an orderly fashion which is pleasing to the eye. Another point related to this subject is the systematic control mechanism which is necessary for collecting taxes regularly and updating. In this paper, first practical meaning of notice and advertisement subject, problem definition and objectives are described and then legal support and daily practice are revised. Current practice and problems are mentioned. Possibilities of measuring and obtaining necessary information by using digital images and transferring them to spatial databases are studied. By this study, a modern approach was developed for urban management and municipalities by using information technology which is an alternative to current application. Criteria which provide environmental harmony such as urban beauty, colour, compatibility and safety were also evaluated. It was finally concluded that measuring commercial signs and keeping environmental harmony under control for urban beauty can be provided by Digital Photogrammetry (DP technique and GIS capabilities which were studied with pilot applications in the city center of Ankara.

  14. Emerging vector borne diseases – incidence through vectors

    Directory of Open Access Journals (Sweden)

    Sara eSavic

    2014-12-01

    Full Text Available Vector borne diseases use to be a major public health concern only in tropical and subtropical areas, but today they are an emerging threat for the continental and developed countries also. Nowdays, in intercontinetal countries, there is a struggle with emerging diseases which have found their way to appear through vectors. Vector borne zoonotic diseases occur when vectors, animal hosts, climate conditions, pathogens and susceptible human population exist at the same time, at the same place. Global climate change is predicted to lead to an increase in vector borne infectious diseases and disease outbreaks. It could affect the range and popultion of pathogens, host and vectors, transmission season, etc. Reliable surveilance for diseases that are most likely to emerge is required. Canine vector borne diseases represent a complex group of diseases including anaplasmosis, babesiosis, bartonellosis, borreliosis, dirofilariosis, erlichiosis, leishmaniosis. Some of these diseases cause serious clinical symptoms in dogs and some of them have a zoonotic potential with an effect to public health. It is expected from veterinarians in coordination with medical doctors to play a fudamental role at primeraly prevention and then treatment of vector borne diseases in dogs. The One Health concept has to be integrated into the struggle against emerging diseases.During a four year period, from 2009-2013, a total number of 551 dog samples were analysed for vector borne diseases (borreliosis, babesiosis, erlichiosis, anaplasmosis, dirofilariosis and leishmaniasis in routine laboratory work. The analysis were done by serological tests – ELISA for borreliosis, dirofilariosis and leishmaniasis, modified Knott test for dirofilariosis and blood smear for babesiosis, erlichiosis and anaplasmosis. This number of samples represented 75% of total number of samples that were sent for analysis for different diseases in dogs. Annually, on avarege more then half of the samples

  15. Ribosomal DNA Integrating rAAV-rDNA Vectors Allow for Stable Transgene Expression

    OpenAIRE

    Lisowski, Leszek; Lau, Ashley; Wang, Zhongya; Zhang, Yue(Walter Burke Institute for Theoretical Physics, California Institute of Technology, Pasadena, CA, 91125, U.S.A.); Zhang, Feijie; Grompe, Markus; Kay, Mark A

    2012-01-01

    Although recombinant adeno-associated virus (rAAV) vectors are proving to be efficacious in clinical trials, the episomal character of the delivered transgene restricts their effectiveness to use in quiescent tissues, and may not provide lifelong expression. In contrast, integrating vectors enhance the risk of insertional mutagenesis. In an attempt to overcome both of these limitations, we created new rAAV-rDNA vectors, with an expression cassette flanked by ribosomal DNA (rDNA) sequences cap...

  16. A new method to customize protein expression vectors for fast, efficient and background free parallel cloning

    OpenAIRE

    Scholz, J.; Besir, H.; Strasser, C; Suppmann, S

    2013-01-01

    Background: Expression and purification of correctly folded proteins typically require screening of different parameters such as protein variants, solubility enhancing tags or expression hosts. Parallel vector series that cover all variations are available, but not without compromise. We have established a fast, efficient and absolutely background free cloning approach that can be applied to any selected vector. Results: Here we describe a method to tailor selected expression vectors for para...

  17. Chikungunya Virus–Vector Interactions

    Directory of Open Access Journals (Sweden)

    Lark L. Coffey

    2014-11-01

    Full Text Available Chikungunya virus (CHIKV is a mosquito-borne alphavirus that causes chikungunya fever, a severe, debilitating disease that often produces chronic arthralgia. Since 2004, CHIKV has emerged in Africa, Indian Ocean islands, Asia, Europe, and the Americas, causing millions of human infections. Central to understanding CHIKV emergence is knowledge of the natural ecology of transmission and vector infection dynamics. This review presents current understanding of CHIKV infection dynamics in mosquito vectors and its relationship to human disease emergence. The following topics are reviewed: CHIKV infection and vector life history traits including transmission cycles, genetic origins, distribution, emergence and spread, dispersal, vector competence, vector immunity and microbial interactions, and co-infection by CHIKV and other arboviruses. The genetics of vector susceptibility and host range changes, population heterogeneity and selection for the fittest viral genomes, dual host cycling and its impact on CHIKV adaptation, viral bottlenecks and intrahost diversity, and adaptive constraints on CHIKV evolution are also discussed. The potential for CHIKV re-emergence and expansion into new areas and prospects for prevention via vector control are also briefly reviewed.

  18. Chiral structure of vector and axial-vector tetraquark currents

    International Nuclear Information System (INIS)

    We investigate the chiral structure of local vector and axial-vector tetraquark currents, and study their chiral transformation properties. We consider the charge-conjugation parity and classify all the isovector vector and axial-vector local tetraquark currents of quantum numbers IG JPC =1-1-+, IG JPC =1+1--, IG JPC = 1-1++ and IG JPC = 1+1+-. We find that there is a one to one correspondence among them. Using these currents, we perform QCD sum rule analyses. Our results suggest that there is a missing b1 state having IG JPC =1+1+- and a mass around 1.47-1.66 GeV. (orig.)

  19. Q Vector Analysis of Torrential Rainfall from Meiyu Front Cyclone:A Case Study

    Institute of Scientific and Technical Information of China (English)

    YUE Caijun

    2009-01-01

    Following similar derivation of quasi-geostrophic Q vector (QG), a new Q vector (QN) is constructed in this study. Their difference is that the geostrophic wind in quasi-geostrophic Q vector is replaced by the wind in QN vector. The diagnostic analysis of QN vector is compared with that of QG vector in the case study of a typical Meiyu front cyclone (MYFC) occurred over Changjiang-Huaihe regions during 5-6 July 1991. The results show that the QN vector has more diagnostic advantages than QG vector does. Convergence of QN vector at 700 hPa is found to be a good indicator to mimic the horizontal distribution of precipitation. QN vector is further partitioned into four components: QalstN (along-stream stretching), QcurvN (curvature) QshdvN (shear advection), and QalstN (cross-stream stretching) in a natural coordinate system with isohypse (PG partitioning). The application of QN PG partitioning in the MYFC torrential rain indicates that PG of QcurvN on rainfall enhancement fade from the mature stage to decay stage. QshdvN enhances precipitation significantly as the MYFC develops, and the effect weakens rapidly when the MYFC decays during its eastward propagation. QcrstN shows little impacts on rainfall during the onset and mature phases whereas it displays significant role during the decay phase.QalstN and QcurvN, QshdvN and QcrstN show cancellation only during the decay period.

  20. On the Witt vector Frobenius

    DEFF Research Database (Denmark)

    Davis, Christopher James; Kedlaya, Kiran

    2014-01-01

    We study the kernel and cokernel of the Frobenius map on the p-typical Witt vectors of a commutative ring, not necessarily of characteristic p. We give many equivalent conditions to surjectivity of the Frobenius map on both finite and infinite length Witt vectors. In particular, surjectivity on...... finite Witt vectors turns out to be stable under certain integral extensions; this provides a clean formulation of a strong generalization of Faltings’s almost purity theorem from p-adic Hodge theory, incorporating recent improvements by Kedlaya–Liu and by Scholze....

  1. Vector control of induction machines

    CERN Document Server

    Robyns, Benoit

    2012-01-01

    After a brief introduction to the main law of physics and fundamental concepts inherent in electromechanical conversion, ""Vector Control of Induction Machines"" introduces the standard mathematical models for induction machines - whichever rotor technology is used - as well as several squirrel-cage induction machine vector-control strategies. The use of causal ordering graphs allows systematization of the design stage, as well as standardization of the structure of control devices. ""Vector Control of Induction Machines"" suggests a unique approach aimed at reducing parameter sensitivity for

  2. Towards the Development of an Automated Learning Assistant for Vector Calculus: Integration over Planar Regions

    Science.gov (United States)

    Yaacob, Yuzita; Wester, Michael; Steinberg, Stanly

    2010-01-01

    This paper presents a prototype of a computer learning assistant ILMEV (Interactive Learning-Mathematica Enhanced Vector calculus) package with the purpose of helping students to understand the theory and applications of integration in vector calculus. The main problem for students using Mathematica is to convert a textbook description of a…

  3. Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens.

    Science.gov (United States)

    Antrobus, Richard D; Coughlan, Lynda; Berthoud, Tamara K; Dicks, Matthew D; Hill, Adrian Vs; Lambe, Teresa; Gilbert, Sarah C

    2014-03-01

    Adenoviruses are potent vectors for inducing and boosting cellular immunity to encoded recombinant antigens. However, the widespread seroprevalence of neutralizing antibodies to common human adenovirus serotypes limits their use. Simian adenoviruses do not suffer from the same drawbacks. We have constructed a replication-deficient chimpanzee adenovirus-vectored vaccine expressing the conserved influenza antigens, nucleoprotein (NP), and matrix protein 1 (M1). Here, we report safety and T-cell immunogenicity following vaccination with this novel recombinant simian adenovirus, ChAdOx1 NP+M1, in a first in human dose-escalation study using a 3+3 study design, followed by boosting with modified vaccinia virus Ankara expressing the same antigens in some volunteers. We demonstrate ChAdOx1 NP+M1 to be safe and immunogenic. ChAdOx1 is a promising vaccine vector that could be used to deliver vaccine antigens where strong cellular immune responses are required for protection. PMID:24374965

  4. Vaccinia Virus LC16m8∆ as a Vaccine Vector for Clinical Applications

    Directory of Open Access Journals (Sweden)

    Minoru Kidokoro

    2014-10-01

    Full Text Available The LC16m8 strain of vaccinia virus, the active ingredient in the Japanese smallpox vaccine, was derived from the Lister/Elstree strain. LC16m8 is replication-competent and has been administered to over 100,000 infants and 3,000 adults with no serious adverse reactions. Despite this outstanding safety profile, the occurrence of spontaneously-generated large plaque-forming virulent LC16m8 revertants following passage in cell culture is a major drawback. We identified the gene responsible for the reversion and deleted the gene (B5R from LC16m8 to derive LC16m8Δ. LC16m8∆ is non-pathogenic in immunodeficient severe combined immunodeficiency (SCID mice, genetically-stable and does not reverse to a large-plaque phenotype upon passage in cell culture, even under conditions in which most LC16m8 populations are replaced by revertants. Moreover, LC16m8∆ is >500-fold more effective than the non-replicating vaccinia virus (VV, Modified Vaccinia Ankara (MVA, at inducing murine immune responses against pathogenic VV. LC16m8∆, which expresses the SIV gag gene, also induced anti-Gag CD8+ T-cells more efficiently than MVA and another non-replicating VV, Dairen I minute-pock variants (DIs. Moreover, LC16m8∆ expressing HIV-1 Env in combination with a Sendai virus vector induced the production of anti-Env antibodies and CD8+ T-cells. Thus, the safety and efficacy of LC16m8∆ mean that it represents an outstanding platform for the development of human vaccine vectors.

  5. Chimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults.

    Science.gov (United States)

    Green, Christopher A; Scarselli, Elisa; Sande, Charles J; Thompson, Amber J; de Lara, Catherine M; Taylor, Kathryn S; Haworth, Kathryn; Del Sorbo, Mariarosaria; Angus, Brian; Siani, Loredana; Di Marco, Stefania; Traboni, Cinzia; Folgori, Antonella; Colloca, Stefano; Capone, Stefania; Vitelli, Alessandra; Cortese, Riccardo; Klenerman, Paul; Nicosia, Alfredo; Pollard, Andrew J

    2015-08-12

    Respiratory syncytial virus (RSV) causes respiratory infection in annual epidemics, with infants and the elderly at particular risk of developing severe disease and death. However, despite its importance, no vaccine exists. The chimpanzee adenovirus, PanAd3-RSV, and modified vaccinia virus Ankara, MVA-RSV, are replication-defective viral vectors encoding the RSV fusion (F), nucleocapsid (N), and matrix (M2-1) proteins for the induction of humoral and cellular responses. We performed an open-label, dose escalation, phase 1 clinical trial in 42 healthy adults in which four different combinations of prime/boost vaccinations were investigated for safety and immunogenicity, including both intramuscular (IM) and intranasal (IN) administration of the adenovirus-vectored vaccine. The vaccines were safe and well tolerated, with the most common reported adverse events being mild injection site reactions. No vaccine-related serious adverse events occurred. RSV neutralizing antibody titers rose in response to IM prime with PanAd3-RSV and after IM boost for individuals primed by the IN route. Circulating anti-F immunoglobulin G (IgG) and IgA antibody-secreting cells (ASCs) were observed after the IM prime and IM boost. RSV-specific T cell responses were increased after the IM PanAd3-RSV prime and were most efficiently boosted by IM MVA-RSV. Interferon-γ (IFN-γ) secretion after boost was from both CD4(+) and CD8(+) T cells, without detectable T helper cell 2 (TH2) cytokines that have been previously associated with immune pathogenesis following exposure to RSV after the formalin-inactivated RSV vaccine. In conclusion, PanAd3-RSV and MVA-RSV are safe and immunogenic in healthy adults. These vaccine candidates warrant further clinical evaluation of efficacy to assess their potential to reduce the burden of RSV disease. PMID:26268313

  6. All optical vector magnetometer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This Phase I research project will investigate a novel method of operating an atomic magnetometer to simultaneously measure total magnetic fields and vector...

  7. Acoustic vector sensor signal processing

    Institute of Scientific and Technical Information of China (English)

    SUN Guiqing; LI Qihu; ZHANG Bin

    2006-01-01

    Acoustic vector sensor simultaneously, colocately and directly measures orthogonal components of particle velocity as well as pressure at single point in acoustic field so that is possible to improve performance of traditional underwater acoustic measurement devices or detection systems and extends new ideas for solving practical underwater acoustic engineering problems. Although acoustic vector sensor history of appearing in underwater acoustic area is no long, but with huge and potential military demands, acoustic vector sensor has strong development trend in last decade, it is evolving into a one of important underwater acoustic technology. Under this background, we try to review recent progress in study on acoustic vector sensor signal processing, such as signal detection, DOA estimation, beamforming, and so on.

  8. Introduction to matrices and vectors

    CERN Document Server

    Schwartz, Jacob T

    2012-01-01

    In this concise undergraduate text, the first three chapters present the basics of matrices - in later chapters the author shows how to use vectors and matrices to solve systems of linear equations. 1961 edition.

  9. Vectoring of parallel synthetic jets

    Science.gov (United States)

    Berk, Tim; Ganapathisubramani, Bharathram; Gomit, Guillaume

    2015-11-01

    A pair of parallel synthetic jets can be vectored by applying a phase difference between the two driving signals. The resulting jet can be merged or bifurcated and either vectored towards the actuator leading in phase or the actuator lagging in phase. In the present study, the influence of phase difference and Strouhal number on the vectoring behaviour is examined experimentally. Phase-locked vorticity fields, measured using Particle Image Velocimetry (PIV), are used to track vortex pairs. The physical mechanisms that explain the diversity in vectoring behaviour are observed based on the vortex trajectories. For a fixed phase difference, the vectoring behaviour is shown to be primarily influenced by pinch-off time of vortex rings generated by the synthetic jets. Beyond a certain formation number, the pinch-off timescale becomes invariant. In this region, the vectoring behaviour is determined by the distance between subsequent vortex rings. We acknowledge the financial support from the European Research Council (ERC grant agreement no. 277472).

  10. Axisymmetric Coanda-assisted vectoring

    Energy Technology Data Exchange (ETDEWEB)

    Allen, Dustin; Smith, Barton L. [Utah State University, Mechanical and Aerospace Engineering, Logan, UT (United States)

    2009-01-15

    An experimental demonstration of a jet vectoring technique used in our novel spray method called Coanda-assisted Spray Manipulation (CSM) is presented. CSM makes use of the Coanda effect on axisymmetric geometries through the interaction of two jets: a primary jet and a control jet. The primary jet has larger volume flow rate but generally a smaller momentum flux than the control jet. The primary jet flows through the center of a rounded collar. The control jet is parallel to the primary and is adjacent to the convex collar. The Reynolds number range for the primary jet at the exit plane was between 20,000 and 80,000. The flow was in the incompressible Mach number range (Mach<0.3). The control jet attaches to the convex wall and vectors according to known Coanda effect principles, entraining and vectoring the primary jet, resulting in controllable r-{theta} directional spraying. Several annular control slots and collar radii were tested over a range of momentum flux ratios to determine the effects of these variables on the vectored jet angle and spreading. Two and Three-component Particle Image Velocimetry systems were used to determine the vectoring angle and the profile of the combined jet in each experiment. The experiments show that the control slot and expansion radius, along with the momentum ratios of the two jets predominantly affected the vectoring angle and profile of the combined jets. (orig.)

  11. Decays of the vector glueball

    CERN Document Server

    Giacosa, Francesco; Janowski, Stanislaus

    2016-01-01

    We calculate two- and three-body decays of the (lightest) vector glueball into (pseudo)scalar, (axial-)vector, as well as pseudovector and excited vector mesons. By setting the mass of this yet hypothetical vector glueball to 3.8 GeV as predicted by Lattice QCD, many branching ratios can be computed and represent a parameter-free prediction of our approach. We find that the decay mode $\\omega\\pi\\pi$ should be one of the largest (both through the decay chain $\\mathcal{O}\\rightarrow b_{1}\\pi\\rightarrow$ $\\omega\\pi\\pi$ and through the direct coupling $\\mathcal{O}\\rightarrow\\omega\\pi\\pi$)$.$ Similarly, the (direct and indirect) decay into $\\pi KK^{\\ast}(892)$ is sizable. Moreover, the decays into $\\rho\\pi$ and $K^{\\ast}(892)K$ are, although subleading, possible and could play a role in explaining the $\\rho\\pi$ puzzle of the charmonium state $\\psi(2S)$ thank to a (small) mixing with the vector glueball. The vector glueball can be directly formed at the ongoing BESIII experiment as well as at the future PANDA exper...

  12. Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants

    Directory of Open Access Journals (Sweden)

    Rosenqvist Nina

    2009-02-01

    Full Text Available Abstract Background Lentiviral vectors hold great promise as gene transfer vectors in gene therapeutic settings. However, problems related to the risk of insertional mutagenesis, transgene silencing and positional effects have stalled the use of such vectors in the clinic. Chromatin insulators are boundary elements that can prevent enhancer-promoter interactions, if placed between these elements, and protect transgene cassettes from silencing and positional effects. It has been suggested that insulators can improve the safety and performance of lentiviral vectors. Therefore insulators have been incorporated into lentiviral vectors in order to enhance their safety profile and improve transgene expression. Commonly such insulator vectors are produced at lower titers than control vectors thus limiting their potential use. Results In this study we cloned in tandem copies of the chicken β-globin insulator (cHS4 on both sides of the transgene cassette in order to enhance the insulating effect. Our insulator vectors were produced at significantly lower titers compared to control vectors, and we show that this reduction in titer is due to a block during the transduction process that appears after reverse transcription but before integration of the viral DNA. This non-integrated viral DNA could be detected by PCR and, importantly, prevented efficient transduction of target cells. Conclusion These results have importance for the future use of insulator sequences in lentiviral vectors and might limit the use of insulators in vectors for in vivo use. Therefore, a careful analysis of the optimal design must be performed before insulators are included into clinical lentiviral vectors.

  13. The use of certified seeds of improved wheat varieties in farms and the contributions of certified seed usage to enterprise economies: the case of Ankara province in Turkey.

    Science.gov (United States)

    Tanrivermiş, Harun; Akdoğan, Ilyas

    2007-12-15

    In this research, the use of certificated seeds of improved wheat varieties in farms of Ankara, which have an important share in wheat production of Turkey and the contributions of the certified seeds usage to enterprise economy have been evaluated by using data collected from farms via a questionnaire. The low level of use of certificated wheat seed in farms is associated with many factors, such as price of the seed (cost), yield gains and suitability of the varieties for the farming aims of producers. Average productivity is 49.5% and average net profit is 39.7% higher in the production of wheat with certificated seeds of improved varieties in farms in comparison to farming with traditional varieties. Average productivity in wheat production with uncertified seeds of improved varieties is 24.9% and net profit per unit area is 24.3% higher than wheat production with traditional varieties. The net economic benefit of wheat production using certificated seeds of improved varieties and that of wheat farming with uncertified seeds has been estimated at $ 102.40 and $ 62.70 ha(-1), respectively. Some $ 6.4 benefit is generated in return for $ 1 of expense in wheat farming with certificated seeds of improved varieties instead of traditional varieties. In the absence of state subsidies for certificated seeds the use of uncertified seeds seems to be advantageous for producers. While the amount of subsidy per hectare will be a minimum of $ 101 for certificated seeds per hectare of planting area (as technological improvement), the support will be encouraging for usage of certified seeds. Many variables, such as farm size, use of certified seeds, topography of land, production system, education level and frequency of visiting the agriculture organizations of the producers influence the level of gross profit per unit area in wheat farming. Low level of use of certificated seed in farms decreases the economic benefit of new varieties which are developed as a result of long

  14. İngiliz Kültür Heyeti Ankara Kütüphanesi Okuyucuları ve Çevrimiçi Okuyucu Katalogu

    Directory of Open Access Journals (Sweden)

    Selma Alpay Aslan

    1993-03-01

    Full Text Available Çevrimiçi okuyucu kataloglarının (ÇOK, derme ile ilgili kaynakçasal bilgilere erişim olanaklarını zenginleştirme, tümleşik dizgelerde ödünç verme bilgisinini de içerme gibi yararları vardır. İngiliz Kültür Heyeti Ankara Kütüphanesi (İKHAK 1992'de otomasyona geçmiş ve katalogunu ÇOK'a dönüştürmüştür. Bir okuyucu anketine dayanılarak okuyucuların bu yeniliği nasıl karşıladıkları, ÇOK'u ne ölçüde değerlendirdikleri, nasıl öğrendikleri ve kullandıkları, karşılaştıkları güçlüklerin neler olduğu ve ÇOK hakkındaki düşünceleri araştırılmıştır. Araştırma, İKHAK okuyucularının %64.4'nün katalog türü olarak ÇOK'u yeğlediklerini, kataloğu kullananların %75.3'nün ÇOK'un kullanımını kolay bulduğunu, bu kullanıcıların yaklaşık yarısının kullanımı doğrudan dizgiden öğrenmek istediklerini ve doyum düzeyinin %80'in üzerinde olduğunu göstermiştir. Yorum yapan okuyucular, yukarıda belirtilen yararlar dışında, ÇOK'un okuyucuya zaman kazandırdığım, kitap seçimini kolaylaştırdığını da vurgulamışlardır. Bütün bu bulgular okuyuculara ÇOK sunabilmenin hizmetlerin geliştirilmesinde yararlı bir uygulama olduğunu ve bu yatırımın yerindeliğini ortaya koymuştur.

  15. Political And Economic Approach Of Women Working In Executive Levels In The Service Sector: Ankara State Opera And Ballet (Asob Case

    Directory of Open Access Journals (Sweden)

    Ilkben Akansel

    2012-04-01

    Full Text Available Political economy is related to how capitalist system works by means of distribution of economical and cultural sources which has also a connection between the circumstances of women’s working life. Because hegemony, which is reflected to hegemony’s ideology, constitutes its force by the mediation of the concepts: ‘discrimination’ and ‘segregation’. This force sometimes can effect women as both earning much less in some labor-force market, facing to harassment etc. and being obstructed to get top-level managerial positions in which institutes their work by means of political economy point of view.In this study, we will examine the art sector which is one of the sub-branches of service sector in the labor-force market. Our case is Ankara State Opera and Ballet (ASOB. In this case, we aim to display how the institution is founded, and accepted as a part of modernization with the beginning of Republic of Turkey and changed especially by means of political approaches in the last years.While doing this, we will elaborate the concepts of ‘discrimination’ and ‘segregation’ which issues women face in the labor-force market. Then, we will relate these three concepts with Antonio Gramsci’s ‘hegemony’ and Louis Althusser’s ‘ideology’, Michel Foucault’s ‘power’  and we will examine how women are assigned to the executive positions in the case of institution which we have chosen.We will study the circumstances which may be narrowed as; whether women are permitted to work in the top-level management or not, how many women have been worked in the top-level management in the history of the institution, if quantity has a meaning or not etc., by means of political economy.By the mediation of aforementioned subjects, we will analyse the reasons of women being prevented to work in the top-level management in the working life by economical, political and social aspects. Consequently, we will elaborate how political economy, in

  16. Ankara Üniversitesi öğrencilerinin kadınların spor etkinliklerine katılımlarına ilişkin görüşleri

    OpenAIRE

    KIZILYALLI, Meltem

    2014-01-01

    Bu araştırmanın amacı Ankara Üniversitesi öğrencilerinin kadınların spor etkinliklerine katılımlarına ilişkin görüşlerini belirlemektir. Çalışmanın evrenini, 2012-2013 akademik yılında Ankara Üniversitesinde öğrenim gören İletişim Fakültesi, İlahiyat Fakültesi ve Mühendislik Fakültesi Yabancı Diller Hazırlık ve 4. Sınıf öğrencileri oluşturmaktadır. Bu amaçla üç fakülteden 2397 kişilik evrenden, 750 kişiye ölçme aracı uygulanmıştır. Araştırmanın verileri araştırmacı tarafı...

  17. Sanat sektöründe kadin işgücünün konumu: Ankara Devlet Opera ve Balesi çerçevesinde bir örnekleme

    OpenAIRE

    Akansel, İlkben

    2004-01-01

    Sanat sektörü, hizmetler sektörü içinde daha marjinal bir alandır. Sanat sektörü, çok geniş bir alanı kapsadığı için, çalışmamız Ankara Devlet Opera ve Balesi üzerinde temellendirilmiştir. Bu sektörde çalışan kadınlar bir dizi sorunla karşı karşıyadır. Şöyle ki, çalışma yaşamında kadınların genelde karşılaştığı sorunların yanı sıra, kurumdaki kendine özgü çalışma koşulları kadınlar üzerinde ek baskılara neden olabilmektedir. Ankara Devlet Opera ve Balesi’nde yaptığımız ön inceleme ve dah...

  18. Ankara Üniversitesi Uzaktan Eğitim Programına Katılan Öğrencilerin Akademik Başarılarını Yordayan Faktörler

    Directory of Open Access Journals (Sweden)

    Selma Şenel

    2015-12-01

    Full Text Available The aim of this study was to determine the factors predicting academic achievement of Ankara University Distance Education students. The study group of the research consists of 302 first grade students from Ankara University Distance Education Center (ANKUZEM 2010-2011 associate degree programs. Data were formed in four groups respectively “individual characteristics”, “characteristics related with family and working environment”, “characteristics related with usage of information and communication technologies” and “characteristics related with education”. Data were analyzed by stepwise multiple regression analysis. According to the results, individual characteristics as “age”, “working in a full time job” and “being divorced” were found as predictors of students’ academic achievement. Additionally, characteristics related with family and working place as “number of family members living with”, “mothers’ full time working” and “mothers’ graduation type” were other variables predicting academic achievement of students. The characteristics related with education; graduation from “college” and “vocational high school”, “studying with different methods“, “choosing distance education as a university degree”, “studying for getting a degree” are also predictors of academic achievement of students. The characteristics of students related with usage of information and communication technologies were not predictors of academic achievement of students.

  19. WAVELET KERNEL SUPPORT VECTOR MACHINES FOR SPARSE APPROXIMATION

    Institute of Scientific and Technical Information of China (English)

    Tong Yubing; Yang Dongkai; Zhang Qishan

    2006-01-01

    Wavelet, a powerful tool for signal processing, can be used to approximate the target function. For enhancing the sparse property of wavelet approximation, a new algorithm was proposed by using wavelet kernel Support Vector Machines (SVM), which can converge to minimum error with better sparsity. Here, wavelet functions would be firstly used to construct the admitted kernel for SVM according to Mercy theory; then new SVM with this kernel can be used to approximate the target funciton with better sparsity than wavelet approxiamtion itself. The results obtained by our simulation experiment show the feasibility and validity of wavelet kernel support vector machines.

  20. Increased Mucosal CD4+ T Cell Activation in Rhesus Macaques following Vaccination with an Adenoviral Vector

    OpenAIRE

    Bukh, Irene; Calcedo, Roberto; Roy, Soumitra; Carnathan, Diane G.; Grant, Rebecca; Qin, Qiuyue; Boyd, Surina; Ratcliffe, Sarah J.; Veeder, Christin L; Bellamy, Scarlett L.; Betts, Michael R.; James M Wilson

    2014-01-01

    The possibility that vaccination with adenovirus (AdV) vectors increased mucosal T cell activation remains a central hypothesis to explain the potential enhancement of HIV acquisition within the Step trial. Modeling this within rhesus macaques is complicated because human adenoviruses, including human adenovirus type 5 (HAdV-5), are not endogenous to macaques. Here, we tested whether vaccination with a rhesus macaque-derived adenoviral vector (simian adenovirus 7 [SAdV-7]) enhances mucosal T ...

  1. Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

    OpenAIRE

    Modlich, Ute; Bohne, Jens; Schmidt, Manfred; von Kalle, Christof; Knöss, Sabine; Schambach, Axel; Baum, Christopher

    2006-01-01

    Retroviral vectors with long terminal repeats (LTRs), which contain strong enhancer/promoter sequences at both ends of their genome, are widely used for stable gene transfer into hematopoietic cells. However, recent clinical data and mouse models point to insertional activation of cellular proto-oncogenes as a dose-limiting side effect of retroviral gene delivery that potentially induces leukemia. Self-inactivating (SIN) retroviral vectors do not contain the terminal repetition of the enhance...

  2. The Duality on Vector Optimization Problems

    Institute of Scientific and Technical Information of China (English)

    HUANG Long-guang

    2012-01-01

    Duality framework on vector optimization problems in a locally convex topological vector space are established by using scalarization with a cone-strongly increasing function.The dualities for the scalar convex composed optimization problems and for general vector optimization problems are studied.A general approach for studying duality in vector optimization problems is presented.

  3. A NOTE ON VECTOR CASCADE ALGORITHM

    Institute of Scientific and Technical Information of China (English)

    Qiu-hui Chen; Jin-zhao Liu; Wen-sheng Zhang

    2002-01-01

    The focus of this paper is on the relationship between accuracy of multivariate refinable vector and vector cascade algorithm. We show that, if the vector cascade algorithm (1.5) with isotropic dilation converges to a vector-valued function with regularity, then the initial function must satisfy the Strang-Fix conditions.

  4. Vector meson-vector meson interaction and dynamically generated resonances

    International Nuclear Information System (INIS)

    We report upon 11 composite meson states, dynamically generated from the vector meson–vector meson interaction using the local hidden gauge formalism within a unitary approach. Six of these states are associated to the f0(1370), f0(1710), f2(1270), f'2(1525), a2(1320) and K*2(1430) resonances. At the same time we predict five other states with the quantum numbers of h1, a0, b1, K*0, and K1 which could be tested by future experiments.

  5. A generalized nonlocal vector calculus

    Science.gov (United States)

    Alali, Bacim; Liu, Kuo; Gunzburger, Max

    2015-10-01

    A nonlocal vector calculus was introduced in Du et al. (Math Model Meth Appl Sci 23:493-540, 2013) that has proved useful for the analysis of the peridynamics model of nonlocal mechanics and nonlocal diffusion models. A formulation is developed that provides a more general setting for the nonlocal vector calculus that is independent of particular nonlocal models. It is shown that general nonlocal calculus operators are integral operators with specific integral kernels. General nonlocal calculus properties are developed, including nonlocal integration by parts formula and Green's identities. The nonlocal vector calculus introduced in Du et al. (Math Model Meth Appl Sci 23:493-540, 2013) is shown to be recoverable from the general formulation as a special example. This special nonlocal vector calculus is used to reformulate the peridynamics equation of motion in terms of the nonlocal gradient operator and its adjoint. A new example of nonlocal vector calculus operators is introduced, which shows the potential use of the general formulation for general nonlocal models.

  6. Axisymmetric Coanda-assisted vectoring

    Science.gov (United States)

    Allen, Dustin; Smith, Barton L.

    2009-01-01

    An experimental demonstration of a jet vectoring technique used in our novel spray method called Coanda-assisted Spray Manipulation (CSM) is presented. CSM makes use of the Coanda effect on axisymmetric geometries through the interaction of two jets: a primary jet and a control jet. The primary jet has larger volume flow rate but generally a smaller momentum flux than the control jet. The primary jet flows through the center of a rounded collar. The control jet is parallel to the primary and is adjacent to the convex collar. The Reynolds number range for the primary jet at the exit plane was between 20,000 and 80,000. The flow was in the incompressible Mach number range (Mach Coanda effect principles, entraining and vectoring the primary jet, resulting in controllable r - θ directional spraying. Several annular control slots and collar radii were tested over a range of momentum flux ratios to determine the effects of these variables on the vectored jet angle and spreading. Two and Three-component Particle Image Velocimetry systems were used to determine the vectoring angle and the profile of the combined jet in each experiment. The experiments show that the control slot and expansion radius, along with the momentum ratios of the two jets predominantly affected the vectoring angle and profile of the combined jets.

  7. Pre-existing immunity against vaccine vectors--friend or foe?

    Science.gov (United States)

    Saxena, Manvendra; Van, Thi Thu Hao; Baird, Fiona J; Coloe, Peter J; Smooker, Peter M

    2013-01-01

    Over the last century, the successful attenuation of multiple bacterial and viral pathogens has led to an effective, robust and safe form of vaccination. Recently, these vaccines have been evaluated as delivery vectors for heterologous antigens, as a means of simultaneous vaccination against two pathogens. The general consensus from published studies is that these vaccine vectors have the potential to be both safe and efficacious. However, some of the commonly employed vectors, for example Salmonella and adenovirus, often have pre-existing immune responses in the host and this has the potential to modify the subsequent immune response to a vectored antigen. This review examines the literature on this topic, and concludes that for bacterial vectors there can in fact, in some cases, be an enhancement in immunogenicity, typically humoral, while for viral vectors pre-existing immunity is a hindrance for subsequent induction of cell-mediated responses. PMID:23175507

  8. Evolving lessons on nanomaterial-coated viral vectors for local and systemic gene therapy.

    Science.gov (United States)

    Kasala, Dayananda; Yoon, A-Rum; Hong, Jinwoo; Kim, Sung Wan; Yun, Chae-Ok

    2016-07-01

    Viral vectors are promising gene carriers for cancer therapy. However, virus-mediated gene therapies have demonstrated insufficient therapeutic efficacy in clinical trials due to rapid dissemination to nontarget tissues and to the immunogenicity of viral vectors, resulting in poor retention at the disease locus and induction of adverse inflammatory responses in patients. Further, the limited tropism of viral vectors prevents efficient gene delivery to target tissues. In this regard, modification of the viral surface with nanomaterials is a promising strategy to augment vector accumulation at the target tissue, circumvent the host immune response, and avoid nonspecific interactions with the reticuloendothelial system or serum complement. In the present review, we discuss various chemical modification strategies to enhance the therapeutic efficacy of viral vectors delivered either locally or systemically. We conclude by highlighting the salient features of various nanomaterial-coated viral vectors and their prospects and directions for future research. PMID:27348247

  9. Comparison of lentiviral vector titration methods

    OpenAIRE

    Debyser Zeger; Baekelandt Veerle; Willems Sofie; Geraerts Martine; Gijsbers Rik

    2006-01-01

    Abstract Background Lentiviral vectors are efficient vehicles for stable gene transfer in dividing and non-dividing cells. Several improvements in vector design to increase biosafety and transgene expression, have led to the approval of these vectors for use in clinical studies. Methods are required to analyze the quality of lentiviral vector production, the efficiency of gene transfer and the extent of therapeutic gene expression. Results We compared lentiviral vector titration methods that ...

  10. Chaotic Inflation in Supergravity from Massive Vector Multiplets

    CERN Document Server

    Farakos, Fotis

    2014-01-01

    We study the embedding of the quadratic model of chaotic inflation into the 4D, N=1 minimal theories of supergravity. In the framework of the new-minimal formulation, this embedding is straightforward if one makes use of a real linear multiplet coupled to a vector multiplet, in other words, a massive vector multiplet. The potential for the lowest component of the real linear superfield, which is identified as the inflaton, is generated by a 4D analog of the Green-Schwarz term, and gives rise to a pure single-field quadratic model of chaotic inflation. This theory is protected by an enhanced symmetry which naturally suppresses the higher order corrections. The embedding in the old-minimal formulation is again achieved in terms of a massive vector multiplet and also gives rise to single-field inflation, nevertheless in this case one needs significant fine-tuning of the higher order terms.

  11. Fiber propagation of vector modes

    CERN Document Server

    Ndagano, Bienvenu; McLaren, Melanie; Duparre, Michael; Forbes, Andrew

    2015-01-01

    Here we employ both dynamic and geometric phase control of light to produce radially modulated vector-vortex modes, the natural modes of optical fibers. We then measure these modes using a vector modal decomposition set-up as well as a tomography measurement, the latter providing a degree of the non-separability of the vector states, akin to an entanglement measure for quantum states. We demonstrate the versatility of the approach by creating the natural modes of a step-index fiber, which are known to exhibit strong mode coupling, and measure the modal cross-talk and non-separability decay during propagation. Our approach will be useful in mode division multiplexing schemes for transport of classical and quantum states.

  12. Gauge Theories of Vector Particles

    Science.gov (United States)

    Glashow, S. L.; Gell-Mann, M.

    1961-04-24

    The possibility of generalizing the Yang-Mills trick is examined. Thus we seek theories of vector bosons invariant under continuous groups of coordinate-dependent linear transformations. All such theories may be expressed as superpositions of certain "simple" theories; we show that each "simple theory is associated with a simple Lie algebra. We may introduce mass terms for the vector bosons at the price of destroying the gauge-invariance for coordinate-dependent gauge functions. The theories corresponding to three particular simple Lie algebras - those which admit precisely two commuting quantum numbers - are examined in some detail as examples. One of them might play a role in the physics of the strong interactions if there is an underlying super-symmetry, transcending charge independence, that is badly broken. The intermediate vector boson theory of weak interactions is discussed also. The so-called "schizon" model cannot be made to conform to the requirements of partial gauge-invariance.

  13. Introduction to vector velocity imaging

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Udesen, Jesper; Hansen, Kristoffer Lindskov;

    virtually impossible to compensate for the factor and obtain correct velocity estimates for either CFM or spectral velocity estimation. This talk will describe methods for finding the correct velocity by estimating both the axial and lateral component of the velocity vector. The transverse oscillation...... method introduces an ultrasound field that oscillation not only along the ultrasound beam both also transverse to it to estimate both the lateral and axial velocity for the full velocity vector. The correct velocity magnitude can be found from this as well as the instantaneous angle. This can be obtained...... over the full region of interest and a real time image at a frame rate of 20 Hz can be displayed. Real time videos have been obtained from both our research systems and from commercial BK Medical scanners. The vector velocity images reveal the full complexity of the human blood flow. It is easy to see...

  14. 3D vector flow imaging

    DEFF Research Database (Denmark)

    Pihl, Michael Johannes

    The main purpose of this PhD project is to develop an ultrasonic method for 3D vector flow imaging. The motivation is to advance the field of velocity estimation in ultrasound, which plays an important role in the clinic. The velocity of blood has components in all three spatial dimensions, yet...... conventional methods can estimate only the axial component. Several approaches for 3D vector velocity estimation have been suggested, but none of these methods have so far produced convincing in vivo results nor have they been adopted by commercial manufacturers. The basis for this project is the Transverse...... on the TO fields are suggested. They can be used to optimize the TO method. In the third part, a TO method for 3D vector velocity estimation is proposed. It employs a 2D phased array transducer and decouples the velocity estimation into three velocity components, which are estimated simultaneously based on 5...

  15. Toward lattice fractional vector calculus

    Science.gov (United States)

    Tarasov, Vasily E.

    2014-09-01

    An analog of fractional vector calculus for physical lattice models is suggested. We use an approach based on the models of three-dimensional lattices with long-range inter-particle interactions. The lattice analogs of fractional partial derivatives are represented by kernels of lattice long-range interactions, where the Fourier series transformations of these kernels have a power-law form with respect to wave vector components. In the continuum limit, these lattice partial derivatives give derivatives of non-integer order with respect to coordinates. In the three-dimensional description of the non-local continuum, the fractional differential operators have the form of fractional partial derivatives of the Riesz type. As examples of the applications of the suggested lattice fractional vector calculus, we give lattice models with long-range interactions for the fractional Maxwell equations of non-local continuous media and for the fractional generalization of the Mindlin and Aifantis continuum models of gradient elasticity.

  16. Bred vectors, singular vectors, and Lyapunov vectors in simple and complex models

    Science.gov (United States)

    Norwood, Adrienne

    We compute and compare three types of vectors frequently used to explore the instability properties of dynamical models, Lyapunov vectors (LVs), singular vectors (SVs), and bred vectors (BVs). The first model is the Lorenz (1963) three-variable model. We find BVs align with the locally fastest growing LV, which is often the second fastest growing global LV. The growth rates of the three types of vectors reveal all predict regime changes and durations of new regimes, as shown for BVs by Evans et al. (2004). The second model is the toy 'atmosphere-ocean model' developed by Pena and Kalnay (2004) coupling three Lorenz (1963) models with different time scales to test the effects of fast and slow modes of growth on the dynamical vectors. A fast 'extratropical atmosphere' is weakly coupled to a fast 'tropical atmosphere' which is strongly coupled to a slow 'ocean' system, the latter coupling imitating the tropical El Nino--Southern Oscillation. BVs separate the fast and slow modes of growth through appropriate selection of the breeding parameters. LVs successfully separate the fast 'extratropics' but cannot completely decouple the 'tropics' from the 'ocean,' leading to 'coupled' LVs that are affected by both systems but mainly dominated by one. SVs identify the fast modes but cannot capture the slow modes until the fast 'extratropics' are replaced with faster 'convection.' The dissimilar behavior of the three types of vectors degrades the similarities of the subspaces they inhabit (Norwood et al. 2013). The third model is a quasi-geostrophic channel model (Rotunno and Bao 1996) that is a simplification of extratropical synoptic-scale motions with baroclinic instabilities only. We were unable to successfully compute LVs for it. However, randomly initialized BVs quickly converge to a single vector that is the leading LV. The last model is the SPEEDY model created by Molteni (2003). It is a simplified general atmospheric circulation model with several types of instabilities

  17. The vector BPS Skyrme model

    OpenAIRE

    Adam, C.; C. Naya; Sanchez-Guillen, J.; Wereszczynski, A.

    2012-01-01

    We analyze the vector meson formulation of the BPS Skyrme model in (3+1) dimensions, where the term of sixth power in first derivatives characteristic for the original, integrable BPS Skyrme model (the topological or baryon current squared) is replaced by a coupling between the vector meson $\\omega_\\mu$ and the baryon current. We find that the model remains integrable in the sense of generalized integrability and almost solvable (reducible to a set of two first order ODEs) for any value of th...

  18. Evaluation of integrated vector management.

    Science.gov (United States)

    van den Berg, Henk; Takken, Willem

    2009-02-01

    Initiatives on integrated vector management (IVM) approaches are increasingly undertaken as alternatives to existing vector control. An impact model of IVM is presented with performance and impact indicators at six causal steps from coverage of the intervention to impact on disease. Impacts in fields other than health are also discussed because of the emphasis in IVM on capacity building, partnerships and sustainability. A conceptual framework for evaluation of IVM is designed, based on considerations of the selection of indicators, level of inference, cluster size and method of evaluation. The framework, which is tested in three case studies, is intended as guidance for public health workers and policy-makers. PMID:19110470

  19. Black Holes With Vector Hair

    OpenAIRE

    Fan, Zhong-Ying

    2016-01-01

    In this paper, we consider Einstein gravity coupled to a vector field, either minimally or non-minimally, together with a vector potential of the type $V=2\\Lambda_0+\\ft 12 m^2 A^2+\\gamma_4 A^4$. For a simpler non-minimally coupled theory with $\\Lambda_0=m=\\gamma_4=0$, we obtain both extremal and non-extremal black hole solutions that are asymptotic to Minkowski space-times. We study the global properties of the solutions and derive the first law of thermodynamics using Wald formalism. We find...

  20. On Spinors and Null Vectors

    CERN Document Server

    Budinich, Marco

    2014-01-01

    We investigate the relations between spinors and null vectors in Clifford algebra with particular emphasis on the conditions that a spinor must satisfy to be simple (also: pure). In particular we prove: i) a new property for null vectors: each of them bisects spinor space into two parts of equal size; ii) that simple spinors form one-dimensional subspaces of spinor space; iii) a necessary and sufficient condition for a spinor to be simple that generalizes a theorem of Cartan and Chevalley that appears now as a corollary of this result. We also show how to write down easily the most general spinor with a given associated totally null plane.

  1. Topological vector spaces and distributions

    CERN Document Server

    Horvath, John

    2012-01-01

    ""The most readable introduction to the theory of vector spaces available in English and possibly any other language.""-J. L. B. Cooper, MathSciNet ReviewMathematically rigorous but user-friendly, this classic treatise discusses major modern contributions to the field of topological vector spaces. The self-contained treatment includes complete proofs for all necessary results from algebra and topology. Suitable for undergraduate mathematics majors with a background in advanced calculus, this volume will also assist professional mathematicians, physicists, and engineers.The precise exposition o

  2. Learning with Support Vector Machines

    CERN Document Server

    Campbell, Colin

    2010-01-01

    Support Vectors Machines have become a well established tool within machine learning. They work well in practice and have now been used across a wide range of applications from recognizing hand-written digits, to face identification, text categorisation, bioinformatics, and database marketing. In this book we give an introductory overview of this subject. We start with a simple Support Vector Machine for performing binary classification before considering multi-class classification and learning in the presence of noise. We show that this framework can be extended to many other scenarios such a

  3. Enhanced performance hybrid-arq

    KAUST Repository

    Fareed, Muhammad Mehboob

    2016-06-16

    Apparatuses, computer readable media, and methods are provided for enhancing hybrid automatic repeat request (ARQ) performance. In an example method, a communication device transmits a first element of a vector, where the vector is selected using the information bits to be transmitted as an index in a code book. In some embodiments, this code book is constructed using Linear Constellation Precoding (LCP). If a NACK is received, the communication device transmits a second element of the vector. The process of transmitting elements of the vector continues until an ACK is received or the maximum number of transmission attempts is reached. If an ACK is received, the communication device transmits a first element of another vector of the code book that encodes a second set of information bits. This procedure may continue until all information bits have been transmitted successfully.

  4. Quantum nonlinear lattices and coherent state vectors

    DEFF Research Database (Denmark)

    Ellinas, Demosthenes; Johansson, M.; Christiansen, Peter Leth

    1999-01-01

    Quantized nonlinear lattice models are considered for two different classes, boson and fermionic ones. The quantum discrete nonlinear Schrodinger model (DNLS) is our main objective, but its so called modified discrete nonlinear (MDNLS) version is also included, together with the fermionic polaron...... ansatz made for the state vectors invokes the study of the Riemannian and symplectic geometry of the CSV manifolds as generalized phase spaces. Next, we investigate analytically and numerically the behavior of mean values and uncertainties of some physically interesting observables as well as the...... modifications in the quantum regime of processes such as the discrete self trapping (DST), in terms of the Q-function and the distribution of excitation quanta of the lattice sites. Quantum DST in the symmetric ordering of lattice operators is found to be relatively enhanced with respect to the classical DST...

  5. Vector Space Over Division Ring

    OpenAIRE

    Kleyn, Aleks

    2005-01-01

    A system of linear equations over a skew field has properties similar to properties of a system of linear equations over a field. Even noncommutativity of a product creates a new picture the properties of system of linear equations and of vector space over skew-field have a close relationship.

  6. Some properties of vector gluinonium

    International Nuclear Information System (INIS)

    Strong radiation transitions between the levels of the gluonic bound states are considered. The decay probability for vector gluinonium into Z-bozon and has calculated, and the possibility to observe this state in the Z-bozon and gluon jet

  7. Vector-meson dominance revisited

    Directory of Open Access Journals (Sweden)

    Terschlüsen Carla

    2012-12-01

    Full Text Available The interaction of mesons with electromagnetism is often well described by the concept of vector-meson dominance (VMD. However, there are also examples where VMD fails. A simple chiral Lagrangian for pions, rho and omega mesons is presented which can account for the respective agreement and disagreement between VMD and phenomenology in the sector of light mesons.

  8. Scalar Calibration of Vector Magnetometers

    DEFF Research Database (Denmark)

    Merayo, José M.G.; Brauer, Peter; Primdahl, Fritz;

    2000-01-01

    The calibration parameters of a vector magnetometer are estimated only by the use of a scalar reference magnetometer. The method presented in this paper differs from those previously reported in its linearized parametrization. This allows the determination of three offsets or signals in the absence...

  9. On Weighted Support Vector Regression

    DEFF Research Database (Denmark)

    Han, Xixuan; Clemmensen, Line Katrine Harder

    2014-01-01

    We propose a new type of weighted support vector regression (SVR), motivated by modeling local dependencies in time and space in prediction of house prices. The classic weights of the weighted SVR are added to the slack variables in the objective function (OF‐weights). This procedure directly...

  10. Reference vectors in economic choice

    Directory of Open Access Journals (Sweden)

    Teycir Abdelghani GOUCHA

    2013-07-01

    Full Text Available In this paper the introduction of notion of reference vector paves the way for a combination of classical and social approaches in the framework of referential preferences given by matrix groups. It is shown that individual demand issue from rational decision does not depend on that reference.

  11. Portfolio Analysis for Vector Calculus

    Science.gov (United States)

    Kaplan, Samuel R.

    2015-01-01

    Classic stock portfolio analysis provides an applied context for Lagrange multipliers that undergraduate students appreciate. Although modern methods of portfolio analysis are beyond the scope of vector calculus, classic methods reinforce the utility of this material. This paper discusses how to introduce classic stock portfolio analysis in a…

  12. Vector description of nonlinear magnetization

    International Nuclear Information System (INIS)

    The definition of the nonlinear magnetization, which is usually applied in investigating superconductors is discussed in this paper. The nonlinear magnetization of the superconductor, as the response to the alternating magnetic field, is a periodic time function and is determined by the sequence of complex numbers χn=χn'+iχn'', n=1,2,3,.... The sequence χn is named harmonic susceptibility. Finding some limits in this definition we propose a new description, substituting the complex sequence χn with the sequence of real covariant vectors. Such a definition of the nonlinear magnetization, allows to determine function M(t) of an investigated system for an arbitrary initial phase θo of the inducing magnetic field Hac=hac sin(ωt+θo). Vector description, in our opinion, is superior to the complex one in respect of explicitness, simplicity, and universality. Circular diagrams are used to illustrate the new vector description. We also show how the vectors of the harmonic susceptibility can be derived from both numeric calculations and experimental data

  13. Parallel Sparse Matrix - Vector Product

    DEFF Research Database (Denmark)

    Alexandersen, Joe; Lazarov, Boyan Stefanov; Dammann, Bernd

    This technical report contains a case study of a sparse matrix-vector product routine, implemented for parallel execution on a compute cluster with both pure MPI and hybrid MPI-OpenMP solutions. C++ classes for sparse data types were developed and the report shows how these class can be used...

  14. Sum rule analysis of vector and axial-vector spectral functions with excited states in vacuum

    OpenAIRE

    Hohler, Paul M.; Rapp, Ralf

    2012-01-01

    We simultaneously analyze vector and axial-vector spectral functions in vacuum using hadronic models constrained by experimental data and the requirement that Weinberg-type sum rules are satisfied. Upon explicit inclusion of an excited vector state, viz. rho', and the requirement that the perturbative continua are degenerate in vector and axial-vector channels, we deduce the existence of an excited axial-vector resonance state, a1', in order that the Weinberg sum rules are satisfied. The resu...

  15. Beam quality measure for vector beams.

    Science.gov (United States)

    Ndagano, Bienvenu; Sroor, Hend; McLaren, Melanie; Rosales-Guzmán, Carmelo; Forbes, Andrew

    2016-08-01

    Vector beams have found a myriad of applications, from laser materials processing to microscopy, and are now easily produced in the laboratory. They are usually differentiated from scalar beams by qualitative measures, for example, visual inspection of beam profiles after a rotating polarizer. Here we introduce a quantitative beam quality measure for vector beams and demonstrate it on cylindrical vector vortex beams. We show how a single measure can be defined for the vector quality, from 0 (purely scalar) to 1 (purely vector). Our measure is derived from a quantum toolkit, which we show applies to classical vector beams. PMID:27472580

  16. A Modified Vaccinia Ankara Virus (MVA) Vaccine Expressing African Horse Sickness Virus (AHSV) VP2 Protects Against AHSV Challenge in an IFNAR −/− Mouse Model

    OpenAIRE

    Castillo-Olivares, Javier; Calvo-Pinilla, Eva; Casanova, Isabel; Bachanek-Bankowska, Katarzyna; Chiam, Rachael; Maan, Sushila; Nieto, Jose Maria; Ortego, Javier; Mertens, Peter Paul Clement

    2011-01-01

    African horse sickness (AHS) is a lethal viral disease of equids, which is transmitted by Culicoides midges that become infected after biting a viraemic host. The use of live attenuated vaccines has been vital for the control of this disease in endemic regions. However, there are safety concerns over their use in non-endemic countries. Research efforts over the last two decades have therefore focused on developing alternative vaccines based on recombinant baculovirus or live viral vectors exp...

  17. Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology.

    Science.gov (United States)

    Sizemore, Rachel J; Seeger-Armbruster, Sonja; Hughes, Stephanie M; Parr-Brownlie, Louise C

    2016-04-01

    Viral vectors were originally developed to deliver genes into host cells for therapeutic potential. However, viral vector use in neuroscience research has increased because they enhance interpretation of the anatomy and physiology of brain circuits compared with conventional tract tracing or electrical stimulation techniques. Viral vectors enable neuronal or glial subpopulations to be labeled or stimulated, which can be spatially restricted to a single target nucleus or pathway. Here we review the use of viral vectors to examine the structure and function of motor and limbic basal ganglia (BG) networks in normal and pathological states. We outline the use of viral vectors, particularly lentivirus and adeno-associated virus, in circuit tracing, optogenetic stimulation, and designer drug stimulation experiments. Key studies that have used viral vectors to trace and image pathways and connectivity at gross or ultrastructural levels are reviewed. We explain how optogenetic stimulation and designer drugs used to modulate a distinct pathway and neuronal subpopulation have enhanced our mechanistic understanding of BG function in health and pathophysiology in disease. Finally, we outline how viral vector technology may be applied to neurological and psychiatric conditions to offer new treatments with enhanced outcomes for patients. PMID:26888111

  18. High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe.

    OpenAIRE

    Okazaki, K.; Okazaki, N.; Kume, K.; Jinno, S; Tanaka, K; Okayama, H

    1990-01-01

    We describe a highly efficient alkali cation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of fission yeast Schizosaccharomyces pombe mutants. cDNA libraries constructed with the pcD or pcD2 vector are transduced into yeast by cotransfection with a linearized vector, which allows an enhanced homologous recombination between the yeast vector and the library plasmid leading to the efficient formation of concatemers containing pcD molecules. The tran...

  19. Ankara'da çeşitli kaynaklardan satın alınan beyaz peynirlerin mikrobiyolojik kalite kontrolü üzerinde araştırmalar

    OpenAIRE

    URHAN, Gülay

    2012-01-01

    Bu çalışmada, 2011 yılı Temmuz-Eylül ayları arasında Ankara ilinin çeşitli semtlerindeki marketlerde ve halk pazarlarında satışa sunulan 50 adet beyaz peynir örneği mikrobiyolojik özellikleri bakımından incelenmiştir.Mikrobiyolojik analizler sonucunda örneklerde ortalama toplam mezofil aerobik bakteri sayısı 5,8 x 106 kob/g, maya ve küf sayısı 1,2 x 106 kob/g ve koliform bakteri sayısı ise 5,4 x 102 EMS/g olarak tespit edilmiştir. Ayrıca her bir örnekte E. coli, S. aureus...

  20. Ankara Ekolojik Şartlarında Farklı Ekim Zamanlarının Ketencik (Camelina sativa (L.) Crantz) Bitkisinin Verim Ve Verim Unsurları Üzerine Etkisi

    OpenAIRE

    Katar, Duran; Arslan, Yusuf; Subaşı, İlhan

    2013-01-01

    ÖZET : Bu çalışma, Ankara ekolojik koşullarında 2010 ve 2011 yıllarında farklı ekim zamanın ketencik (Camelina sativa (L.) Crantz) bitkisinin bitki boyu (cm), bin tohum ağırlığı (g), dekara tohum verimi (kg/da) ve yağ oranı (%) üzerine etkisini belirlemek amacıyla yapılmıştır. Deneme Tesadüf Blokları deneme desenine göre üç tekerrürlü olarak kurulmuştur. Bitki boyunda (cm), bin tohum ağırlığında (g), dekara tohum veriminde (kg/da) ve yağ oranı ...

  1. PEGylation of a Vesicular Stomatitis Virus G Pseudotyped Lentivirus Vector Prevents Inactivation in Serum

    Science.gov (United States)

    Croyle, Maria A.; Callahan, Shellie M.; Auricchio, Alberto; Schumer, Gregg; Linse, Klause D.; Wilson, James M.; Brunner, Lane J.; Kobinger, Gary P.

    2004-01-01

    One disadvantage of vesicular stomatitis virus G (VSV-G) pseudotyped lentivirus vectors for clinical application is inactivation of the vector by human serum complement. To prevent this, monomethoxypoly(ethylene) glycol was conjugated to a VSV-G-human immunodeficiency virus vector expressing Escherichia coli beta-galactosidase. The modification did not affect transduction efficiency in vitro and protected the vector from inactivation in complement-active human and mouse sera. Blood from mice dosed intravenously with either the unmodified or the PEGylated virus particles was assayed for active vector by a limiting-dilution assay to evaluate transduction efficiency and for p24, an indicator of the total number of virus particles present. PEGylation extended the circulation half-life of active vector by a factor of 5 and reduced the rate of vector inactivation in the serum by a factor of 1,000. Pharmacokinetic profiles for the total number of virus particles present in the circulation were unaffected by PEGylation. Modification of the vector with poly(ethylene) glycol significantly enhanced transduction efficiency in the bone marrow and in the spleen 14 days after systemic administration of the virus. These results, in concert with the pharmacokinetic profiles, indicate that PEGylation does protect the virus from inactivation in the serum and, as a result, improves the transduction efficiency of VSV-G pseudotyped lentivirus vectors in susceptible organs in vivo. PMID:14694122

  2. A Large U3 Deletion Causes Increased In Vivo Expression from a Nonintegrating Lentiviral Vector

    Science.gov (United States)

    Bayer, Matthew; Kantor, Boris; Cockrell, Adam; Ma, Hong; Zeithaml, Brian; Li, Xiangping; McCown, Thomas; Kafri, Tal

    2008-01-01

    The feasibility of employing nonintegrating lentiviral vectors has been demonstrated by recent studies showing the ability of nonintegrating lentiviral vectors to maintain transgene expression in vitro and in vivo. Furthermore, HIV-1 vectors packaged with a mutated integrase were able to correct retinal disease in a mouse model. Interestingly, these results differ from earlier studies in which first-generation nonintegrating lentiviral vectors yielded insignificant levels of transduction. However, to date a rigorous characterization of transgene expression from the currently used self-inactivating (SIN) nonintegrating lentiviral vectors has not been published. Here we characterize transgene expression from SIN nonintegrating lentiviral vectors. Overall, we found that nonintegrating vectors express transgenes at a significantly lower level than their integrating counterparts. Expression from nonintegrating vectors was improved upon introducing a longer deletion in the vector’s U3 region. A unique shuttle-vector assay indicated that the relative abundance of the different episomal forms was not altered by the longer U3 deletion. Interestingly, the longer U3 deletion did not enhance expression in the corpus callosum of the rat brain, suggesting that the extent of silencing of episomal transcription is influenced by tissue-specific factors. Finally, and for the first time, episomal expression in the mouse liver was potent and sustained. PMID:18797449

  3. B5 deficient vaccinia virus as a vaccine vector for the expression of a foreign antigen in vaccinia immune animals

    OpenAIRE

    Viner, Kendra M.; Girgis, Natasha; Kwak, Heesun; Isaacs, Stuart N.

    2006-01-01

    Recombinant vaccinia viruses have shown promise as vaccine vectors. However, their effectiveness is markedly reduced by pre-existing anti-vaccinia immunity. The possibility of new vaccinia immunizations in the event of a bioterror-related smallpox release poses an additional negative impact on the utility of vaccinia-based vectors. Thus, we aimed to design a vaccinia vector that would enhance the immune response to an expressed foreign protein in a pre-immune animal model. To do this, we made...

  4. Treatment of canine leukocyte adhesion deficiency by foamy virus vectors expressing CD18 from a PGK promoter

    OpenAIRE

    Bauer, Thomas R; Olson, Erik M.; Huo, Yunwen; Tuschong, Laura M; Allen, James M; Li, Yi; Burkholder, Tanya H; Russell, David W.

    2011-01-01

    Proto-oncogene activation caused by retroviral vector integration can cause malignancies in gene therapy trials. This has led investigators to search for less genotoxic vectors with minimal enhancer activity and a decreased risk of influencing neighboring chromosomal gene expression after integration. We previously showed that foamy virus vectors expressing the canine CD18 gene from an internal murine stem cell virus promoter could cure canine leukocyte adhesion deficiency. Here we have repea...

  5. Dystrophin Delivery to Muscles of mdx Mice Using Lentiviral Vectors Leads to Myogenic Progenitor Targeting and Stable Gene Expression

    OpenAIRE

    Kimura, En; Li, Sheng; Gregorevic, Paul; Fall, Brent M; Jeffrey S. Chamberlain

    2009-01-01

    To explore whether stable transduction of myogenic stem cells using lentiviral vectors could be of benefit for treating dystrophic muscles, we generated vectors expressing a functional microdystrophin/enhanced green fluorescence protein fusion (µDys/eGFP) gene. Lentiviral vector injection into neonatal mdx4cv muscles resulted in widespread and stable expression of dystrophin for at least 2 years. This expression resulted in a significant amelioration of muscle pathophysiology as assessed by a...

  6. Transversals of Complex Polynomial Vector Fields

    DEFF Research Database (Denmark)

    Dias, Kealey

    Vector fields in the complex plane are defined by assigning the vector determined by the value P(z) to each point z in the complex plane, where P is a polynomial of one complex variable. We consider special families of so-called rotated vector fields that are determined by a polynomial multiplied...... by rotational constants. Transversals are a certain class of curves for such a family of vector fields that represent the bifurcation states for this family of vector fields. More specifically, transversals are curves that coincide with a homoclinic separatrix for some rotation of the vector field....... Given a concrete polynomial, it seems to take quite a bit of work to prove that it is generic, i.e. structurally stable. This has been done for a special class of degree d polynomial vector fields having simple equilibrium points at the d roots of unity, d odd. In proving that such vector fields are...

  7. SYSTEM OF GENERALIZED VECTOR VARIATIONAL INEQUALITIES

    Institute of Scientific and Technical Information of China (English)

    Fang Yaping; Huang Nanjing

    2005-01-01

    In this paper, the authors introduce and study system of generalized vector variational inequalities. Under suitable conditions, the existence of solutions for system of generalized vector variational inequalities is presented by Kakutani-Fan-Glicksberg fixed point theorem.

  8. Class Vectors: Embedding representation of Document Classes

    OpenAIRE

    Sachan, Devendra Singh; Kumar, Shailesh

    2015-01-01

    Distributed representations of words and paragraphs as semantic embeddings in high dimensional data are used across a number of Natural Language Understanding tasks such as retrieval, translation, and classification. In this work, we propose "Class Vectors" - a framework for learning a vector per class in the same embedding space as the word and paragraph embeddings. Similarity between these class vectors and word vectors are used as features to classify a document to a class. In experiment o...

  9. Fast Support Vector Machines for Continuous Data

    OpenAIRE

    Kramer, Kurt A.; Hall, Lawrence O.; Goldgof, Dmitry B.; Remsen, Andrew; Luo, Tong

    2009-01-01

    Support vector machines can be trained to be very accurate classifiers and have been used in many applications. However, the training and to a lesser extent prediction time of support vector machines on very large data sets can be very long. This paper presents a fast compression method to scale up support vector machines to large data sets. A simple bit reduction method is applied to reduce the cardinality of the data by weighting representative examples. We then develop support vector machi...

  10. Problems of vector Lagrangians in field theories

    International Nuclear Information System (INIS)

    A vector Lagrange approach to the Dirac spinor field and the relationship between the vector Lagrangians for the spinor and electromagnetic fields are considered. A vector Lagrange approach for the system of interacting electromagnetic B=(Bμυ)=(E-bar,H-bar) and spinor Ψ fields is constructed. New Lagrangians (scalar and vector) for electromagnetic field in terms of field strengths are found. The foundations of two new QED models are formulated

  11. VEST: abstract vector calculus simplification in Mathematica

    OpenAIRE

    Squire, Jonathan; Burby, Joshua; Qin, Hong

    2013-01-01

    We present a new package, VEST (Vector Einstein Summation Tools), that performs abstract vector calculus computations in Mathematica. Through the use of index notation, VEST is able to reduce three-dimensional scalar and vector expressions of a very general type to a well defined standard form. In addition, utilizing properties of the Levi-Civita symbol, the program can derive types of multi-term vector identities that are not recognized by reduction, subsequently applying these to simplify l...

  12. NEVILLE-TYPE VECTOR VALUED RATIONAL INTERPOLANTS

    Institute of Scientific and Technical Information of China (English)

    陈之兵; 顾传青; 徐晨

    2004-01-01

    A new kind of vector valued rational interpolants is established by means of Samelson inverse, with scalar numerator and vector valued denominator. It is essen tially different from that of Graves-Morris(1983), where the interpolants are constructed by Thiele-type continued fractions with vector valued numerator and scalar denominator. The new approach is more suitable to calculate the value of a vector valued function for a given point. And an error formula is also given and proven.

  13. Vector Fields in Holographic Cosmology

    CERN Document Server

    Hartle, James B; Hertog, Thomas

    2013-01-01

    We extend the holographic formulation of the semiclassical no-boundary wave function (NBWF) to models with Maxwell vector fields. It is shown that the familiar saddle points of the NBWF have a representation in which a regular, Euclidean asymptotic AdS geometry smoothly joins onto a Lorentzian asymptotically de Sitter universe through a complex transition region. The tree level probabilities of Lorentzian histories are fully specified by the action of the AdS region of the saddle points. The scalar and vector matter profiles in this region are complex from an AdS viewpoint, with universal asymptotic phases. The dual description of the semiclassical NBWF thus involves complex deformations of Euclidean CFTs.

  14. Vector fields in holographic cosmology

    Science.gov (United States)

    B. Hartle, James; Hawking, S. W.; Hertog, Thomas

    2013-11-01

    We extend the holographic formulation of the semiclassical no-boundary wave function (NBWF) to models with Maxwell vector fields. It is shown that the familiar saddle points of the NBWF have a representation in which a regular, Euclidean asymptotic AdS geometry smoothly joins onto a Lorentzian asymptotically de Sitter universe through a complex transition region. The tree level probabilities of Lorentzian histories are fully specified by the action of the AdS region of the saddle points. The scalar and vector matter profiles in this region are complex from an AdS viewpoint, with universal asymptotic phases. The dual description of the semiclassical NBWF thus involves complex deformations of Euclidean CFTs.

  15. Harmonic projection and multipole Vectors

    CERN Document Server

    Lachièze-Rey, M

    2004-01-01

    We show that the multipole vector decomposition, recently introduced by Copi et al., is a consequence of Sylvester s theorem, and corresponds to the Maxwell representation. Analyzing it in terms of harmonic polynomials, we show that this decomposition, as well as its extension proposed by Katz and Weeks, result in fact from the application of the harmonic projection operator and its inverse. We derive the coefficients of the usual harmonic decomposition from the multipole vectors. We answer to '' an open question '' asked by Katz and Weeks, by showing that the decomposition resulting from their corollary is unstable. We propose however a new decomposition which is stable. We generalize these results to complex functions and polynomials.

  16. On spinors and null vectors

    Science.gov (United States)

    Budinich, Marco

    2014-03-01

    We investigate the relations between spinors and null vectors in Clifford algebra of any dimension with particular emphasis on the conditions that a spinor must satisfy to be simple (also: pure). In particular, we prove: (i) a new property for null vectors: each of them bisects spinor space into two subspaces of equal size; (ii) that simple spinors form one-dimensional subspaces of spinor space; (iii) a necessary and sufficient condition for a spinor to be simple that generalizes a theorem of Cartan and Chevalley which becomes a corollary of this result. We also show how to write down easily the most general spinor with a given associated totally null plane. This paper is dedicated to the memory of my father Paolo Budinich who passed away in November 2013 not before transferring to me his enthusiasm for simple spinors.

  17. Vector fields in holographic cosmology

    OpenAIRE

    Hartle, James B.; Hawking, S. W.; Hertog, Thomas

    2013-01-01

    We extend the holographic formulation of the semiclassical no-boundary wave function (NBWF) to models with Maxwell vector fields. It is shown that the familiar saddle points of the NBWF have a representation in which a regular, Euclidean asymptotic AdS geometry smoothly joins onto a Lorentzian asymptotically de Sitter universe through a complex transition region. The tree level probabilities of Lorentzian histories are fully specified by the action of the AdS region of the saddle points. The ...

  18. Transcriptomics and disease vector control

    Directory of Open Access Journals (Sweden)

    Ranson Hilary

    2010-05-01

    Full Text Available Abstract Next-generation sequencing can be used to compare transcriptomes under different conditions. A study in BMC Genomics applies this approach to investigating the effects of exposure to a range of xenobiotics on changes in gene expression in the larvae of Aedes aegypti, the mosquito vector of dengue fever. See research article http://www.biomedcentral.com/1471-2164/11/216

  19. Vector Analysis in GIS Systems

    OpenAIRE

    Životský, Tomáš

    2009-01-01

    This master's thesis deals with the geographic information systems with an emphasis on so-called vector analysis. The aim of the thesisis to create a library that implements the internal representation of geographic data and performs analytical operation over them. The thesis describes the logical structure of the application andthe hierarchy of abstract classes. In the form of pseudo-code isshown a set of individual computing operations. Work is stronglybased on geographic sys...

  20. Lentiviral vector design using alternative RNA export elements

    Directory of Open Access Journals (Sweden)

    Park Frank

    2007-06-01

    Full Text Available Abstract Background Lentiviral vectors have been designed with complex RNA export sequences in both the integrating and packaging plasmids in order to co-ordinate efficient vector production. Recent studies have attempted to replace the existing complex rev/RRE system with a more simplistic RNA export system from simple retroviruses to make these vectors in a rev-independent manner. Results Towards this end, lentiviral transfer plasmids were modified with various cis-acting DNA elements that co-ordinate RNA export during viral production to determine their ability to affect the efficiency of vector titer and transduction in different immortalized cell lines in vitro. It was found that multiple copies of the constitutive transport element (CTE originating from different simian retroviruses, including simian retrovirus type 1 (SRV-1 and type-2 (SRV-2 and Mason-Pfizer (MPV could be used to eliminate the requirement for the rev responsive element (RRE in the transfer and packaging plasmids with titers >106 T.U./mL (n = 4–8 preparations. The addition of multiple copies of the murine intracisternal type A particle, the woodchuck post-regulatory element (WPRE, or single and dual copies of the simian CTE had minimal effect on viral titer. Immortalized cell lines from different species were found to be readily transduced by VSV-G pseudotyped lentiviral vectors containing the multiple copies of the CTE similar to the findings in HeLa cells, although the simian-derived CTE were found to have a lower infectivity into murine cell lines compared to the other species. Conclusion These studies demonstrated that the rev-responsive element (RRE could be replaced with other constitutive transport elements to produce equivalent titers using lentivectors containing the RRE sequence in vitro, but that concatemerization of the CTE or the close proximity of RNA export sequences was needed to enhance vector production.

  1. Vector and tensor analysis with applications

    CERN Document Server

    Borisenko, A I; Silverman, Richard A

    1979-01-01

    Concise and readable, this text ranges from definition of vectors and discussion of algebraic operations on vectors to the concept of tensor and algebraic operations on tensors. It also includes a systematic study of the differential and integral calculus of vector and tensor functions of space and time. Worked-out problems and solutions. 1968 edition.

  2. Problems with the Method of Correlated Vectors

    Science.gov (United States)

    Ashton, M.C.; Lee, K.

    2005-01-01

    The method of correlated vectors has been used widely to identify variables that are associated with general intelligence (g). Briefly, this method involves finding the correlation between the vector of intelligence subtests' g-loadings and the vector of those subtests' correlations with the variable in question. We describe two major problems…

  3. Toward lattice fractional vector calculus

    International Nuclear Information System (INIS)

    An analog of fractional vector calculus for physical lattice models is suggested. We use an approach based on the models of three-dimensional lattices with long-range inter-particle interactions. The lattice analogs of fractional partial derivatives are represented by kernels of lattice long-range interactions, where the Fourier series transformations of these kernels have a power-law form with respect to wave vector components. In the continuum limit, these lattice partial derivatives give derivatives of non-integer order with respect to coordinates. In the three-dimensional description of the non-local continuum, the fractional differential operators have the form of fractional partial derivatives of the Riesz type. As examples of the applications of the suggested lattice fractional vector calculus, we give lattice models with long-range interactions for the fractional Maxwell equations of non-local continuous media and for the fractional generalization of the Mindlin and Aifantis continuum models of gradient elasticity. (papers)

  4. The New Self-Inactivating Lentiviral Vector for Thalassemia Gene Therapy Combining Two HPFH Activating Elements Corrects Human Thalassemic Hematopoietic Stem Cells

    OpenAIRE

    Papanikolaou, Eleni; Georgomanoli, Maria; Stamateris, Evangelos; Panetsos, Fottes; Karagiorga, Markisia; Tsaftaridis, Panagiotis; Graphakos, Stelios; Anagnou, Nicholas P.

    2011-01-01

    To address how low titer, variable expression, and gene silencing affect gene therapy vectors for hemoglobinopathies, in a previous study we successfully used the HPFH (hereditary persistence of fetal hemoglobin)-2 enhancer in a series of oncoretroviral vectors. On the basis of these data, we generated a novel insulated self-inactivating (SIN) lentiviral vector, termed GGHI, carrying the Aγ-globin gene with the −117 HPFH point mutation and the HPFH-2 enhancer and exhibiting a pancellular patt...

  5. Vector processing efficiency of plasma MHD codes by use of the FACOM 230-75 APU

    International Nuclear Information System (INIS)

    In the framework of pipelined vector architecture, the efficiency of vector processing is assessed with respect to plasma MHD codes in nuclear fusion research. By using a vector processor, the FACOM 230-75 APU, the limit of the enhancement factor due to parallelism of current vector machines is examined for three numerical codes based on a fluid model. Reasonable speed-up factors of approximately 6, 6 and 4 times faster than the highly optimized scalar version are obtained for ERATO (linear stability code), AEOLUS-R1 (nonlinear stability code) and APOLLO (1-1/2D transport code), respectively. Problems of the pipelined vector processor are discussed from the viewpoint of restructuring, optimization and choise of algorithms. In conclusion, the important concept of 'concurrency within pipelined parallelism' is emphasized. (orig.)

  6. Soft Sensing Based on Hilbert-Huang Transform and Wavelet Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Qiang Wang

    2013-07-01

    Full Text Available At present, much more soft sensing have been widely used in industrial process control to improve the quality of product and assure safety in production. A novel method using  Hilbert-Huang transform(HHT combined with wavelet support vector machine(WSVM is put forward.Firstly the method analyzes the intrinsic mode function (IMF obtained after the empirical mode decomposition (EMD, then extracts IMF energy feature as the input feature vectors of the wavelet support vector machine. Based on the wavelet analysis and conditions of the support vector kernel function, a novel multi-dimension admissible support vector wavelet kernel function is presented, which is a multidimensional wavelet kernel, thus enhancing the generalization ability of the SVM. The proposed method is used to build soft sensing of diesel oil solidifying point. Compared with other two models, the result shows that HHT-WSVM approach has a better prediction and generalization.

  7. Vector processing efficiency of plasma MHD codes by use of the FACOM 230-75 APU

    Science.gov (United States)

    Matsuura, T.; Tanaka, Y.; Naraoka, K.; Takizuka, T.; Tsunematsu, T.; Tokuda, S.; Azumi, M.; Kurita, G.; Takeda, T.

    1982-06-01

    In the framework of pipelined vector architecture, the efficiency of vector processing is assessed with respect to plasma MHD codes in nuclear fusion research. By using a vector processor, the FACOM 230-75 APU, the limit of the enhancement factor due to parallelism of current vector machines is examined for three numerical codes based on a fluid model. Reasonable speed-up factors of approximately 6,6 and 4 times faster than the highly optimized scalar version are obtained for ERATO (linear stability code), AEOLUS-R1 (nonlinear stability code) and APOLLO (1-1/2D transport code), respectively. Problems of the pipelined vector processors are discussed from the viewpoint of restructuring, optimization and choice of algorithms. In conclusion, the important concept of "concurrency within pipelined parallelism" is emphasized.

  8. On the Distribution of Norm of Vector Projection and Rejection of Two Complex Normal Random Vectors

    Directory of Open Access Journals (Sweden)

    Mehdi Maleki

    2015-01-01

    Full Text Available Vector projection and vector rejection are highly common and useful operations in mathematics, information theory, and signal processing. In this paper, we find the distribution of the norm of projection and rejection vectors when the original vectors are standard complex normally distributed.

  9. The Geometry of Enhancement in Multiple Regression

    Science.gov (United States)

    Waller, Niels G.

    2011-01-01

    In linear multiple regression, "enhancement" is said to occur when R[superscript 2] = b[prime]r greater than r[prime]r, where b is a p x 1 vector of standardized regression coefficients and r is a p x 1 vector of correlations between a criterion y and a set of standardized regressors, x. When p = 1 then b [is congruent to] r and enhancement cannot…

  10. Effect of CXCR4 gene overexpression mediated by lentiviral vector on the biological characteristics of mesenchymal stem cells

    Institute of Scientific and Technical Information of China (English)

    陈伟

    2013-01-01

    Objective To construct mouse CXC chemokine receptor type 4 (Cxcr4) gene overexpressing lentiviral vector and to evaluate its biological effect on mouse mesenchymal stem cells (MSCs) .Methods Cxcr4 gene was amplified and subcloned into pCR-Blunt vector.Cxcr4gene and enhanced green fluorescent protein (EGFP)

  11. Gaussian statistics for palaeomagnetic vectors

    Science.gov (United States)

    Love, J.J.; Constable, C.G.

    2003-01-01

    With the aim of treating the statistics of palaeomagnetic directions and intensities jointly and consistently, we represent the mean and the variance of palaeomagnetic vectors, at a particular site and of a particular polarity, by a probability density function in a Cartesian three-space of orthogonal magnetic-field components consisting of a single (unimoda) non-zero mean, spherically-symmetrical (isotropic) Gaussian function. For palaeomagnetic data of mixed polarities, we consider a bimodal distribution consisting of a pair of such symmetrical Gaussian functions, with equal, but opposite, means and equal variances. For both the Gaussian and bi-Gaussian distributions, and in the spherical three-space of intensity, inclination, and declination, we obtain analytical expressions for the marginal density functions, the cumulative distributions, and the expected values and variances for each spherical coordinate (including the angle with respect to the axis of symmetry of the distributions). The mathematical expressions for the intensity and off-axis angle are closed-form and especially manageable, with the intensity distribution being Rayleigh-Rician. In the limit of small relative vectorial dispersion, the Gaussian (bi-Gaussian) directional distribution approaches a Fisher (Bingham) distribution and the intensity distribution approaches a normal distribution. In the opposite limit of large relative vectorial dispersion, the directional distributions approach a spherically-uniform distribution and the intensity distribution approaches a Maxwell distribution. We quantify biases in estimating the properties of the vector field resulting from the use of simple arithmetic averages, such as estimates of the intensity or the inclination of the mean vector, or the variances of these quantities. With the statistical framework developed here and using the maximum-likelihood method, which gives unbiased estimates in the limit of large data numbers, we demonstrate how to

  12. Problems and worked solutions in vector analysis

    CERN Document Server

    Shorter, LR

    2014-01-01

    ""A handy book like this,"" noted The Mathematical Gazette, ""will fill a great want."" Devoted to fully worked out examples, this unique text constitutes a self-contained introductory course in vector analysis for undergraduate and graduate students of applied mathematics.Opening chapters define vector addition and subtraction, show how to resolve and determine the direction of two or more vectors, and explain systems of coordinates, vector equations of a plane and straight line, relative velocity and acceleration, and infinitely small vectors. The following chapters deal with scalar and vect

  13. Students' Consistency of Graphical Vector Addition Method on 2-D Vector Addition Tasks

    CERN Document Server

    Hawkins, Jeffrey M; Wittmann, Michael

    2010-01-01

    In a series of ten two-dimensional graphical vector addition questions with varying visual representations, most students stuck to a single solution method, be it correct or incorrect. Changes to the visual representation include placing vectors on a grid, making the vectors arrangements symmetric, varying the separation between vectors, and reversing the direction of either vector. We discuss the questions asked of students and their responses, emphasizing the results of one student who did change solution methods during an interview.

  14. Seasonal variation of surface temperature based on land cover in AnkaraAnkara şehrinde yüzey sıcaklıklarının arazi örtüsüne göre mevsimsel değişimi

    Directory of Open Access Journals (Sweden)

    İhsan Çiçek

    2013-03-01

    Full Text Available In this study, the seasonal variation of the surface temperature of Ankara urban area and its enviroment have been analyzed by using Landsat 7 image. The Landsat 7 images of each month from 2007 to 2011 have been used to analyze the annually changes of the surface temperature. The land cover of the research area was defined with supervised classification method on the basis of the satellite image belonging to 2008 July. After determining the surface temperatures from 6-1 bands of satellite images, the monthly mean surface temperatures were calculated for land cover classification for the period between 2007 and 2011. Accordşng to the results obtained, the surface temperatures are high in summer and low in winter from the air temperatures. all satellite images were taken at 10:00 am, it is found that urban areas are cooler than rural areas at 10:00 am. Regarding the land cover classification, the water surfaces are the coolest surfaces during the whole year. The warmest areas are the grasslands and dry farming areas. While the parks are warmer than the urban areas during the winter, during the summer they are cooler than artificial land covers. The urban areas with higher building density are the cooler surfaces after water bodies. ÖzetBu çalışmada, Ankara şehri ve çevresindeki yüzey sıcaklıklarının yıl içerisindeki değişimi incelenmiştir. 2007-2011 yılları arasında yılın tüm aylarına bir görüntü düşecek şekilde, Landsat 7 uydusu ile alınan görüntülerin kullanıldığı çalışmada, 2008 yılı temmuz ayı görüntüsünden kontrollü sınıflandırma yöntemiyle şehir ve çevresine ait arazi örtüsü oluşturulmuştur. Uydu görüntülerinin 6-1 termal bantından  yüzey sıcaklıkları hesap edildikten sonra, arazi örtülerinin her aya ait ortalama yüzey sıcaklıkları belirlenmiştir. Elde edilen değerlere göre yüzey sıcaklıkları, hava sıcaklığına paralel olarak, yaz aylarında yüksek, k

  15. Multiscale vector fields for image pattern recognition

    Science.gov (United States)

    Low, Kah-Chan; Coggins, James M.

    1990-01-01

    A uniform processing framework for low-level vision computing in which a bank of spatial filters maps the image intensity structure at each pixel into an abstract feature space is proposed. Some properties of the filters and the feature space are described. Local orientation is measured by a vector sum in the feature space as follows: each filter's preferred orientation along with the strength of the filter's output determine the orientation and the length of a vector in the feature space; the vectors for all filters are summed to yield a resultant vector for a particular pixel and scale. The orientation of the resultant vector indicates the local orientation, and the magnitude of the vector indicates the strength of the local orientation preference. Limitations of the vector sum method are discussed. Investigations show that the processing framework provides a useful, redundant representation of image structure across orientation and scale.

  16. Vaccine Design: Replication-Defective Adenovirus Vectors.

    Science.gov (United States)

    Zhou, Xiangyang; Xiang, Zhiquan; Ertl, Hildegund C J

    2016-01-01

    Replication-defective adenovirus (Ad) vectors were initially developed for gene transfer for correction of genetic diseases. Although Ad vectors achieved high levels of transgene product expression in a variety of target cells, expression of therapeutic proteins was found to be transient as vigorous T cell responses directed to components of the vector as well as the transgene product rapidly eliminate Ad vector-transduced cells. This opened the use of Ad vectors as vaccine carriers and by now a multitude of preclinical as well as clinical studies has shown that Ad vectors induce very potent and sustained transgene product-specific T and B cell responses. This chapter provides guidance on developing E1-deleted Ad vectors based on available viral molecular clones. Specifically, it describes methods for cloning, viral rescue and purification as well as quality control studies. PMID:27076309

  17. The vector algebra war: A historical perspective

    CERN Document Server

    Chappell, James M; Hartnett, John G; Abbott, Derek

    2015-01-01

    There are a wide variety of different vector formalisms currently utilized in science. For example, Gibbs three-vectors, spacetime four-vectors, complex spinors for quantum mechanics, quaternions used for rigid body rotations and Clifford multivectors. With such a range of vector formalisms in use, it thus appears that there is as yet no general agreement on a vector formalism suitable for the whole of science. This surprising situation exists today, despite the fact that one of the main goals of nineteenth century science was to correctly describe vectors and the algebra of three-dimensional space. This situation has also had the unfortunate consequence of fragmenting knowledge across many disciplines and requiring a very significant amount of time and effort in learning the different formalisms. We thus review historically the development of our various vector systems and conclude that the Clifford algebra multivector fulfills the goal of correctly describing vectorial quantities in three dimensions.

  18. DBSC-Based Grayscale Line Image Vectorization

    Institute of Scientific and Technical Information of China (English)

    Konstantin Melikhov; Feng Tian; Jie Qiu; Quan Chen; Hock Soon Seah

    2006-01-01

    Vector graphics plays an important role in computer animation and imaging technologies. However present techniques and tools cannot fully replace traditional pencil and paper. Additionally, vector representation of an image is not always available. There is not yet a good solution for vectorizing a picture drawn on a paper. This work attempts to solve the problem of vectorizing grayscale line drawings. The solution proposed uses Disk B-Spline curves to represent strokes of an image in vector form. The algorithm builds a vector representation from a grayscale raster image, which can be a scanned picture for instance. The proposed method uses a Gaussian sliding window to calculate skeleton and perceptive width of a stroke. As a result of vectorization, the given image is represented by a set of Disk B-Spline curves.

  19. Round Randomized Learning Vector Quantization for Brain Tumor Imaging

    Directory of Open Access Journals (Sweden)

    Siti Norul Huda Sheikh Abdullah

    2016-01-01

    Full Text Available Brain magnetic resonance imaging (MRI classification into normal and abnormal is a critical and challenging task. Owing to that, several medical imaging classification techniques have been devised in which Learning Vector Quantization (LVQ is amongst the potential. The main goal of this paper is to enhance the performance of LVQ technique in order to gain higher accuracy detection for brain tumor in MRIs. The classical way of selecting the winner code vector in LVQ is to measure the distance between the input vector and the codebook vectors using Euclidean distance function. In order to improve the winner selection technique, round off function is employed along with the Euclidean distance function. Moreover, in competitive learning classifiers, the fitting model is highly dependent on the class distribution. Therefore this paper proposed a multiresampling technique for which better class distribution can be achieved. This multiresampling is executed by using random selection via preclassification. The test data sample used are the brain tumor magnetic resonance images collected from Universiti Kebangsaan Malaysia Medical Center and UCI benchmark data sets. Comparative studies showed that the proposed methods with promising results are LVQ1, Multipass LVQ, Hierarchical LVQ, Multilayer Perceptron, and Radial Basis Function.

  20. A critical assessment of vector control for dengue prevention.

    Directory of Open Access Journals (Sweden)

    Nicole L Achee

    2015-05-01

    Full Text Available Recently, the Vaccines to Vaccinate (v2V initiative was reconfigured into the Partnership for Dengue Control (PDC, a multi-sponsored and independent initiative. This redirection is consistent with the growing consensus among the dengue-prevention community that no single intervention will be sufficient to control dengue disease. The PDC's expectation is that when an effective dengue virus (DENV vaccine is commercially available, the public health community will continue to rely on vector control because the two strategies complement and enhance one another. Although the concept of integrated intervention for dengue prevention is gaining increasingly broader acceptance, to date, no consensus has been reached regarding the details of how and what combination of approaches can be most effectively implemented to manage disease. To fill that gap, the PDC proposed a three step process: (1 a critical assessment of current vector control tools and those under development, (2 outlining a research agenda for determining, in a definitive way, what existing tools work best, and (3 determining how to combine the best vector control options, which have systematically been defined in this process, with DENV vaccines. To address the first step, the PDC convened a meeting of international experts during November 2013 in Washington, DC, to critically assess existing vector control interventions and tools under development. This report summarizes those deliberations.

  1. Direct numerical simulation of vector-controlled free jets

    Energy Technology Data Exchange (ETDEWEB)

    Tsujimoto, K; Ao, K; Shakouchi, T; Ando, T, E-mail: tujimoto@mach.mie-u.ac.jp [Graduate School of Engineering, Mie University, Tsu, 514-8507 (Japan)

    2011-12-22

    We conduct DNS (direct numerical simulation) of vector controlled free jets. The inflow velocity of jet is periodically oscillated perpendicular to the jet axis. In order to realize the high accurate computation, a discretization in space is performed with hybrid scheme in which Fourier spectral and 6th order compact scheme are adopted. From visualized instantaneous vortex structures, it is found that the flow pattern considerably changes according to the oscillating frequency, i.e., according to the increasing the frequency, wave, bifurcating and flapping modes appear in turn. In order to quantify mixing efficiency under the vector control, as the mixing measure, statistical entropy is investigated. Compared to the uncontrolled jet, the mixing efficiency is improved in order of wavy, flapping and bifurcating modes. Thus the vector control can be expected for the improvement of mixing efficiency. Further to make clear the reason for the mixing enhancement, Snapshot POD and DMD method are applied. The primary flow structures under the vector control are demonstrated.

  2. Direct numerical simulation of vector-controlled free jets

    International Nuclear Information System (INIS)

    We conduct DNS (direct numerical simulation) of vector controlled free jets. The inflow velocity of jet is periodically oscillated perpendicular to the jet axis. In order to realize the high accurate computation, a discretization in space is performed with hybrid scheme in which Fourier spectral and 6th order compact scheme are adopted. From visualized instantaneous vortex structures, it is found that the flow pattern considerably changes according to the oscillating frequency, i.e., according to the increasing the frequency, wave, bifurcating and flapping modes appear in turn. In order to quantify mixing efficiency under the vector control, as the mixing measure, statistical entropy is investigated. Compared to the uncontrolled jet, the mixing efficiency is improved in order of wavy, flapping and bifurcating modes. Thus the vector control can be expected for the improvement of mixing efficiency. Further to make clear the reason for the mixing enhancement, Snapshot POD and DMD method are applied. The primary flow structures under the vector control are demonstrated.

  3. Round Randomized Learning Vector Quantization for Brain Tumor Imaging

    Science.gov (United States)

    2016-01-01

    Brain magnetic resonance imaging (MRI) classification into normal and abnormal is a critical and challenging task. Owing to that, several medical imaging classification techniques have been devised in which Learning Vector Quantization (LVQ) is amongst the potential. The main goal of this paper is to enhance the performance of LVQ technique in order to gain higher accuracy detection for brain tumor in MRIs. The classical way of selecting the winner code vector in LVQ is to measure the distance between the input vector and the codebook vectors using Euclidean distance function. In order to improve the winner selection technique, round off function is employed along with the Euclidean distance function. Moreover, in competitive learning classifiers, the fitting model is highly dependent on the class distribution. Therefore this paper proposed a multiresampling technique for which better class distribution can be achieved. This multiresampling is executed by using random selection via preclassification. The test data sample used are the brain tumor magnetic resonance images collected from Universiti Kebangsaan Malaysia Medical Center and UCI benchmark data sets. Comparative studies showed that the proposed methods with promising results are LVQ1, Multipass LVQ, Hierarchical LVQ, Multilayer Perceptron, and Radial Basis Function.

  4. A simple vector system to improve performance and utilisation of recombinant antibodies

    OpenAIRE

    Vincent Karen J; Mitchell Joanne N; Rojas Gertrudis; Martin Cecile D; Wu Jiahua; McCafferty John; Schofield Darren J

    2006-01-01

    Abstract Background Isolation of recombinant antibody fragments from antibody libraries is well established using technologies such as phage display. Phage display vectors are ideal for efficient display of antibody fragments on the surface of bacteriophage particles. However, they are often inefficient for expression of soluble antibody fragments, and sub-cloning of selected antibody populations into dedicated soluble antibody fragment expression vectors can enhance expression. Results We ha...

  5. Vector meson electroproduction in QCD

    International Nuclear Information System (INIS)

    Based on the generalized QCD vector meson dominance model, we study the electroproduction of a vector meson off a proton in the QCD inspired eikonalized model. Numerical calculations for the total cross section σtot and differential cross section dσ/dt are performed for ρ, ω and φ meson electroproduction in this paper. Since gluons interact among themselves (self-interaction), two gluons can form a glueball with quantum numbers IG, JPC = 0+, 2++, decay width Γt ≈ 100 MeV, and mass of mG=2.23 GeV. The three gluons can form a three-gluon colorless bound state with charge conjugation quantum number C = -1, called the Odderon. The mediators of interactions between projectiles (the quark and antiquark pair fluctuated from the virtual photon) and the proton target (a three-quark system) are the tensor glueball and the Odderon. Our calculated results in the tensor glueball and Odderon exchange model fit to the existing data successfully, which evidently shows that our present QCD mechanism is a good description of meson electroproduction off a proton. It should be emphasized that our mechanism is different from the theoretical framework of Block et al. We also believe that the present study and its success are important for the investigation of other vector meson electro- and photoproduction at high energies, as well as for searching for new particles such as tensor glueballs and Odderons, which have been predicted by QCD and the color glass condensate model (CGC). Therefore, in return, it can test the validity of QCD and the CGC model. (authors)

  6. Vector meson electroproduction in QCD

    Institute of Scientific and Technical Information of China (English)

    LU Juan; CAI Xian-Hao; ZHOU Li-Juan

    2012-01-01

    Based on the generalized QCD vector meson dominance model,we study the electroproduction of a vector meson off a proton in the QCD inspired eikonalized model.Numerical calculations for the total cross section σtot and differential cross section dσ/dt are performed for p,ω and φ meson electroproduction in this paper.Since gluons interact among themselves (self-interaction),two gluons can form a glueball with quantum numbers IG,JPC =0+,2++,decay width Γt ≈ 100 MeV,and mass of mG=2.23 GeV.The three gluons can form a three-gluon colorless bound state with charge conjugation quantum number C =-1,called the Odderon.The mediators of interactions between projectiles (the quark and antiquark pair fluctuated from the virtual photon) and the proton target (a three-quark system) are the tensor glueball and the Odderon.Our calculated results in the tensor glueball and Odderon exchange model fit to the existing data successfully,which evidently shows that our present QCD mechanism is a good description of meson electroproduction off a proton.It should be emphasized that our mechanism is different from the theoretical framework of Block et al.We also believe that the present study and its success are important for the investigation of other vector meson electro- and photoproduction at high energies,as well as for searching for new particles such as tensor glueballs and Odderons,which have been predicted by QCD and the color glass condensate model (CGC).Therefore,in return,it can test the validity of QCD and the CGC model.

  7. Natural gas: new energy vector?

    International Nuclear Information System (INIS)

    Energy history has been characterized by a cyclic irruption of energetic paradigms. This situation induces transformations with great economical and social impacts. A new energetic paradigm comes to scene as a result of several simultaneous acting and feedback factors: primary energy availability, technology innovation in energy conversion systems and environmental, economical and social policies even more restrictive. This paper examines the natural gas as a new energy vector in a world context and justifies the natural gas a fundamental component in the world energy matrix for the next decades

  8. Strange axial-vector mesons

    International Nuclear Information System (INIS)

    The strange axial-vector mesons K1 (1270) and K1 (1400) are reanalyzed in the light of the updated experimental information and compared with the recent result on the Kππ production in τ decay. The mixing angle between the strange mesons of 3P1 and 1P1 is determined by the partial decay rates, and, independently, by the masses. They lead to θK∼33 degree or 57 degree. The observed K1 (1400) production dominance in the τ decay favors θK∼33 degree. Flavor-SU(3) breaking of 20% or so in the production amplitudes can explain quantitatively the observed production ratio

  9. The Vector Valued Quartile Operator

    CERN Document Server

    Lacey, Michael T; Parissis, Ioannis

    2012-01-01

    Certain vector-valued inequalities are shown to hold for a Walsh analog of the bilinear Hilbert transform. These extensions are phrased in terms of a recent notion of quartile type of a UMD (Unconditional Martingale Differences) Banach space X. Every known UMD Banach space has finite quartile type, and it was recently shown that the Walsh analog of Carleson's Theorem holds under a closely related assumption of finite tile type. For a Walsh model of the bilinear Hilbert transform however, the quartile type should be sufficiently close to that of a Hilbert space for our results to hold. A full set of inequalities is quantified in terms of quartile type.

  10. Jet vectoring through nozzle asymmetry

    Science.gov (United States)

    Roh, Chris; Rosakis, Alexandros; Gharib, Morteza

    2015-11-01

    Previously, we explored the functionality of a tri-leaflet anal valve of a dragonfly larva. We saw that the dragonfly larva is capable of controlling the three leaflets independently to asymmetrically open the nozzle. Such control resulted in vectoring of the jet in various directions. To further understand the effect of asymmetric nozzle orifice, we tested jet flow through circular asymmetric nozzles. We report the relationship between nozzle asymmetry and redirecting of the jet at various Reynolds numbers. This material is based upon work supported by the National Science Foundation under Grant No. CBET-1511414; additional support by the National Science Foundation Graduate Research Fellowship under Grant No. DGE-1144469.

  11. Vector quantization for volume rendering

    Science.gov (United States)

    Ning, Paul; Hesselink, Lambertus

    1992-01-01

    Volume rendering techniques typically process volumetric data in raw, uncompressed form. As algorithmic and architectural advances improve rendering speeds, however, larger data sets will be evaluated requiring consideration of data storage and transmission issues. In this paper, we analyze the data compression requirements for volume rendering applications and present a solution based on vector quantization. The proposed system compresses volumetric data and then renders images directly from the new data format. Tests on a fluid flow data set demonstrate that good image quality may be achieved at a compression ratio of 17:1 with only a 5 percent cost in additional rendering time.

  12. Current progress of polymeric gene vectors

    Institute of Scientific and Technical Information of China (English)

    ZENG Xuan; SUN YunXia; ZHUO RenXi; ZHANG XianZheng

    2011-01-01

    After over 40 years ot progress,gene therapy provides great opportunities for treating diseases from various genetic disorders,infections and cancers.The success of gene therapy largely depends on the availability of suitable gene vectors.As an attractive alternative to virus-based gene therapy,non-viral gene delivery system has been developed and investigated due to their merits including low immunogenecity,convenient operability,and large-scale manufacturability [1].Because polycations can condense with DNA as a result of electrostatic interactions,form nanosize polyplexes,and protect DNA from degradation by DNase,cationic polymer becomes a major type of non-viral gene delivery vectors (Figure 1) [2].A wide range of polymeric vectors have been developed and investigated in the past decade,such as polyethylenimine (PEI)-based vectors,poly(L-lysine) (PLL)-based vectors,dendrimer-based vectors,polypeptide-based vectors,and chitosan-based vectors [3].However,unlike viral vectors that have the ability to infect host cells and overcome cellular barriers through the course of evolution,nonviral gene vectors exhibit Significantly reduced transfection efficiency as they are obstructed by various extra- and intracellular barriers,including serum proteins in blood stream,cell membrane,endosomal compartment and nuclear membrane [4].

  13. The vector BPS Skyrme model

    CERN Document Server

    Adam, C; Sanchez-Guillen, J; Wereszczynski, A

    2012-01-01

    We analyze the vector meson formulation of the BPS Skyrme model in (3+1) dimensions, where the term of sixth power in first derivatives characteristic for the original, integrable BPS Skyrme model (the topological or baryon current squared) is replaced by a coupling between the vector meson $\\omega_\\mu$ and the baryon current. We find that the model remains integrable in the sense of generalized integrability and almost solvable (reducible to a set of two first order ODEs) for any value of the baryon charge. Further, we analyze the appearance of topological solitons for two one-parameter families of one vacuum potentials: the old Skyrme potentials and the so-called BPS potentials. Depending on the value of the parameters we find several qualitatively different possibilities. In the massless case we have a parameter region with no skyrmions, a unique compact skyrmion with a discontinuous first derivative at the boundary (equivalently, with a source term located at the boundary, which screens the topological ch...

  14. Coexistence and interaction of vector and bound vector solitons in a dispersion-managed fiber laser mode locked by graphene.

    Science.gov (United States)

    Song, Y F; Zhang, H; Zhao, L M; Shen, D Y; Tang, D Y

    2016-01-25

    We report on the experimental observation of vector and bound vector solitons in a fiber laser passively mode locked by graphene. Localized interactions between vector solitons, vector soliton with bound vector solitons, and vector soliton with a bunch of vector solitons are experimentally investigated. We show that depending on the soliton interactions, various stable and dynamic multiple vector soliton states could be formed. PMID:26832559

  15. Vector leptoquark resolution of RK and R D (*) puzzles

    Science.gov (United States)

    Fajfer, S.; Košnik, N.

    2016-04-01

    We propose that three recent anomalies in B meson decays, R D (*), RK, and P5‧ , might be explained by only one vector leptoquark weak triplet state. The constraints on the parameter space are obtained by considering t → bτ+ ν data, lepton flavor universality tests in the kaon sector, bounds on the lepton flavor violating decay B → Kμτ, and b → cμ- ν bar decays. The presence of such vector leptoquark could be exposed in precise measurements of top semitauonic decays to b quark. The model predicts enhanced decay rate of B → K ν bar ν, approximate equality of lepton flavor universality ratios RK*, RK, and suppressed branching fraction of Bs →μ+μ-.

  16. Vector field instability and the primordial tensor spectrum

    CERN Document Server

    Eccles, Stefan; Lorshbough, Dustin; Stephens, Benjamin A

    2015-01-01

    It has recently been shown that the presence of a spectator pseudoscalar field, coupled to photons through a Chern-Simons term, can amplify the primordial tensor spectrum without observationally disrupting the primordial scalar spectrum. The amplification occurs due to an instability that develops for the vector fields. We extend previous studies to account for the contribution arising from an inhomogeneous vector background, which emerges as the dominant correction to the primordial tensor spectrum. These semiclassical contributions dominate over the quantum loop contributions and possibly enhance the primordial tensor spectrum such as to have observational effects even though the loop corrections might be undetectable. A similar effect would occur by replacing the visible electromagnetic U(1) by an unbroken dark U(1).

  17. Double vector meson production from the BFKL equation

    CERN Document Server

    Gonçalves, V P

    2005-01-01

    The double vector meson production in two photon collisions is addressed assuming that the color singlet $t$-channel exchange carries large momentum transfer. We consider the non-forward solution of the BFKL equation at high energy and large momentum transfer and estimate the total and differential cross section for the process $\\gamma \\gamma \\to V_1 V_2$, where $V_1$ and $V_2$ can be any two vector mesons ($V_i = \\rho, \\omega, \\phi, J/\\Psi, \\Upsilon$). A comparison between our predictions and previous theoretical results obtained at Born level or assuming the Pomeron-exchange factorization relations is presented. Our results demonstrate that the BFKL dynamics implies an enhancement of the cross sections. Predictions for the future linear colliders (TESLA, CLIC and ILC) are given.

  18. The Influence of Delivery Vectors on HIV Vaccine Efficacy

    Directory of Open Access Journals (Sweden)

    BeatriceOmusiroOndondo

    2014-08-01

    Full Text Available Development of an effective HIV/AIDS vaccine remains a big challenge, largely due to the enormous HIV diversity which propels immune escape. Thus novel vaccine strategies are targeting multiple variants of conserved antibody and T cell epitopic regions which would incur a huge fitness cost to the virus in the event of mutational escape. Besides immunogen design, the delivery modality is critical for vaccine potency and efficacy, and should be carefully selected in order to not only maximise transgene expression, but to also enhance the immuno-stimulatory potential to activate innate and adaptive immune systems. To date, five HIV vaccine candidates have been evaluated for efficacy and protection from acquisition was only achieved in a small proportion of vaccinees in the RV144 study which used a canarypox vector for delivery. Conversely, in the STEP study (HVTN 502 where human adenovirus serotype 5 (Ad5 was used, strong immune responses were induced but vaccination was more associated with increased risk of HIV acquisition than protection in vaccinees with pre-existing Ad5 immunity. The possibility that pre-existing immunity to a highly promising delivery vector may alter the natural course of HIV to increase acquisition risk is quite worrisome and a huge setback for HIV vaccine development. Thus, HIV vaccine development efforts are now geared towards delivery platforms which attain superior immunogenicity while concurrently limiting potential catastrophic effects likely to arise from pre-existing immunity or vector-related immuno-modulation. However, it still remains unclear whether it is poor immunogenicity of HIV antigens or substandard immunological potency of the safer delivery vectors that has limited the success of HIV vaccines. This article discusses some of the promising delivery vectors to be harnessed for improved HIV vaccine efficacy.

  19. The influence of delivery vectors on HIV vaccine efficacy.

    Science.gov (United States)

    Ondondo, Beatrice O

    2014-01-01

    Development of an effective HIV/AIDS vaccine remains a big challenge, largely due to the enormous HIV diversity which propels immune escape. Thus novel vaccine strategies are targeting multiple variants of conserved antibody and T cell epitopic regions which would incur a huge fitness cost to the virus in the event of mutational escape. Besides immunogen design, the delivery modality is critical for vaccine potency and efficacy, and should be carefully selected in order to not only maximize transgene expression, but to also enhance the immuno-stimulatory potential to activate innate and adaptive immune systems. To date, five HIV vaccine candidates have been evaluated for efficacy and protection from acquisition was only achieved in a small proportion of vaccinees in the RV144 study which used a canarypox vector for delivery. Conversely, in the STEP study (HVTN 502) where human adenovirus serotype 5 (Ad5) was used, strong immune responses were induced but vaccination was more associated with increased risk of HIV acquisition than protection in vaccinees with pre-existing Ad5 immunity. The possibility that pre-existing immunity to a highly promising delivery vector may alter the natural course of HIV to increase acquisition risk is quite worrisome and a huge setback for HIV vaccine development. Thus, HIV vaccine development efforts are now geared toward delivery platforms which attain superior immunogenicity while concurrently limiting potential catastrophic effects likely to arise from pre-existing immunity or vector-related immuno-modulation. However, it still remains unclear whether it is poor immunogenicity of HIV antigens or substandard immunological potency of the safer delivery vectors that has limited the success of HIV vaccines. This article discusses some of the promising delivery vectors to be harnessed for improved HIV vaccine efficacy. PMID:25202303

  20. A Human Vaccine Strategy Based On Chimpanzee Adenoviral and MVA Vectors That Primes, Boosts and Sustains Functional HCV Specific T-Cell Memory*

    Science.gov (United States)

    Swadling, Leo; Capone, Stefania; Antrobus, Richard D.; Brown, Anthony; Richardson, Rachel; Newell, Evan W.; Halliday, John; Kelly, Christabel; Bowen, Dan; Fergusson, Joannah; Kurioka, Ayako; Ammendola, Virginia; Sorbo, Mariarosaria Del; Grazioli, Fabiana; Esposito, Maria Luisa; Siani, Loredana; Traboni, Cinzia; Hill, Adrian; Colloca, Stefano; Davis, Mark; Nicosia, Alfredo; Cortese, Riccardo; Folgori, Antonella; Klenerman, Paul; Barnes, Eleanor

    2015-01-01

    A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV infects millions of people worldwide and is a leading cause of liver cirrhosis and hepatocellular cancer. Animal challenge experiments, immunogenetics studies and assessment of host immunity during acute infection highlight the critical role that effective T-cell immunity plays in viral control. In this first-in-man study we have induced antiviral immunity with functional characteristics analogous to those associated with viral control in natural infection, and improved upon a vaccine based on adenoviral vectors alone. We assessed a heterologous prime-boost vaccination strategy based on a replicative defective simian adenoviral vector (ChAd3) and modified vaccinia Ankara (MVA) vector encoding the NS3, NS4, NS5A and NS5B proteins of HCV genotype-1b. Analysis employed single cell mass cytometry (CyTOF), and HLA class-I peptide tetramer technology in healthy human volunteers. We show that HCV specific T-cells induced by ChAd3 are optimally boosted with MVA, and generate very high levels of both CD8+ and CD4+ HCV specific T-cells targeting multiple HCV antigens. Sustained memory and effector T-cell populations are generated and T-cell memory evolved over time with improvement of quality (proliferation and polyfunctionality) following heterologous MVA boost. We have developed a HCV vaccine strategy, with durable, broad, sustained and balanced T-cell responses, characteristic of those associated with viral control, paving the way for the first efficacy studies of a prophylactic HCV vaccine. PMID:25378645

  1. A novel replication-competent vaccinia vector MVTT is superior to MVA for inducing high levels of neutralizing antibody via mucosal vaccination.

    Directory of Open Access Journals (Sweden)

    Xiaoxing Huang

    Full Text Available Mucosal vaccination offers great advantage for inducing protective immune response to prevent viral transmission and dissemination. Here, we report our findings of a head-to-head comparison of two viral vectors modified vaccinia Ankara (MVA and a novel replication-competent modified vaccinia Tian Tan (MVTT for inducing neutralizing antibodies (Nabs via intramuscular and mucosal vaccinations in mice. MVTT is an attenuated variant of the wild-type VTT, which was historically used as a smallpox vaccine for millions of Chinese people. The spike glycoprotein (S of SARS-CoV was used as the test antigen after the S gene was constructed in the identical genomic location of two vectors to generate vaccine candidates MVTT-S and MVA-S. Using identical doses, MVTT-S induced lower levels ( approximately 2-3-fold of anti- SARS-CoV neutralizing antibodies (Nabs than MVA-S through intramuscular inoculation. MVTT-S, however, was capable of inducing consistently 20-to-100-fold higher levels of Nabs than MVA-S when inoculated via either intranasal or intraoral routes. These levels of MVTT-S-induced Nab responses were substantially (approximately 10-fold higher than that induced via the intramuscular route in the same experiments. Moreover, pre-exposure to the wild-type VTT via intranasal or intraoral route impaired the Nab response via the same routes of MVTT-S vaccination probably due to the pre-existing anti-VTT Nab response. The efficacy of intranasal or intraoral vaccination, however, was still 20-to-50-fold better than intramuscular inoculation despite the subcutaneous pre-exposure to wild-type VTT. Our data have implications for people who maintain low levels of anti-VTT Nabs after historical smallpox vaccination. MVTT is therefore an attractive live viral vector for mucosal vaccination.

  2. Overview of vector sensors for undersea applications

    Science.gov (United States)

    McEachern, James F.

    2003-10-01

    An overview of vector sensors for sonar applications is presented. The most prolific use of vector or pressure gradient sensors has been in directional sonobuoys to accomplish effective directional measurements with a sensor that is much smaller than the signal wavelength. Common characteristics, implementation issues, and self noise sources of directional hydrophones are reviewed. Arrays of vector sensors began to emerge in the 1980s and have the attractive property of being able to provide substantially higher directivity for a smaller equivalent aperture than that required for a scalar (omnidirectional) sensor array. Dyadic sensors bring additional directivity but development is required to realize them in a compact configuration. Future applications of vector sensors are discussed. The limited amount of information relative to the ocean acoustic vector fields is noted as a corollary technological requirement for the widespread adoption of vector sensors in sonar systems.

  3. A Modified Moist Ageostrophic Q Vector

    Institute of Scientific and Technical Information of China (English)

    YUE Caijun; SHOU Shaowen

    2008-01-01

    The quasi-geostrophic Q vector is an important diagnostic tool for studying development of surface rainfall associated with large-scale weather systems and is calculated using data at single vertical level. When ageostrophic Q vector was introduced, it required data at two vertical levels. In this study, moist ageostrophic Q vector is modified so that it can be calculated using data at a single vertical level. The comparison study between the original and modified moist ageostrophic Q vectors is conducted using the data from 5 to 6 July 1991 during the torrential rainfall event associated with the Changjiang-Huaihe mei-yu front in China. The results reveal that divergences of original and modified moist ageostrophic Q vectors have similar horizontal distributions and their centers are almost located in the precipitation centers. This indicates that modified moist ageostrophic Q vector can be used to diagnose convective development with reasonable accuracy.

  4. Integrated vector management: The Zambian experience

    Directory of Open Access Journals (Sweden)

    Katebe Cecilia

    2008-08-01

    Full Text Available Abstract Background The Zambian Malaria Control Programme with the Roll Back Malaria (RBM partners have developed the current National Malaria Strategic Plan (NMSP 2006–2011 which focuses on prevention based on the Integrated Vector Management (IVM strategy. The introduction and implementation of an IVM strategy was planned in accordance with the World Health Organization (WHO steps towards IVM implementation namely Introduction Phase, Consolidation Phase and Expansion Phase. Achievements IVM has created commitment for Legal and Regulatory policy review, monitoring, Research and a strong stewardship by the chemical suppliers. It has also leveraged additional resources, improved inter-sectoral collaboration, capacity building and enhanced community participation which facilitated a steady scaling up in coverage and utilisation of key preventive interventions. Thus, markedly reducing malaria incidence and case fatalities in the country. Conclusion Zambia has successfully introduced, consolidated and expanded IVM activities. Resulting in increased coverage and utilization of interventions and markedly reducing malaria-related morbidity and mortality while ensuring a better protection of the environment.

  5. Construction of recombinant modified vaccinia virus Ankara with Ag85A and ESAT-6 gene and examination of their immunogenicity in mice%重组结核抗原痘苗病毒Ankara株的构建及其免疫原性研究

    Institute of Scientific and Technical Information of China (English)

    楼觉人; 张群; 朱琳

    2008-01-01

    目的 构建5种不同类型的表达结核杆菌特异抗原的重组痘苗病毒,并研究其特异免疫原性.方法 运用同源重组技术将含结核分泌抗原Ag85A和ESAT-6的基因片段插入痘苗病毒表达质粒p18中.重组质粒导入痘苗病毒Ankara(MVA)后构建重组痘苗病毒,经筛选和Western blot鉴定,得到5个种类的带有结核抗原基因的重组病毒.用构建的5种重组病毒免疫小鼠,MTT法检测免疫后小鼠脾淋巴细胞对特异结核抗原的增殖反应;ELISA检测小鼠脾淋巴细胞培养上清液中IFN-γ的含量;结核菌素纯蛋白衍化物(PPD)皮内试验以检测重组病毒引发的针对结核抗原的特异细胞免疫应答.结果 构建的5种蘑组病毒介导的细胞表达产物经Western blot鉴定确认相对分子质量与结核抗原一致.免疫小鼠两次后,5种重组病毒免疫组脾淋巴细胞体外与Ag85A-ESAT-6融合蛋白共培养后表现出明显的增殖活性(P<0.01),培养上清液中IFN-γ的浓度均较同组细胞经生理盐水刺激明显增高(P<0.05);与空痘苗病毒或生理盐水免疫后小鼠相比,5种重组MVA免疫组脾淋巴细胞与AgB5A.ESAT-6融合蛋白共培养后同样表现出明显的增殖活性(P<0.01),与Ag85A-ESAT-6融合蛋白共培养的细胞上清液中IFN-γ的浓度均升高(P<0.01).与空痘苗病毒或生理盐水免疫后小鼠相比,5种重组MVA免疫组小鼠对PPD都表现出显著的迟发型超敏反应应答(P<0.05).结论 成功构建了5种不同类型的表达结核杆菌抗原的重组痘苗病毒疫苗,其免疫小鼠后可激发针对结核杆菌抗原的特异性细胞免疫.%Objective To construct five types of recombinant modified vaccinia virus Ankara (MVA) carrying genes encoding antigen 85A (Ag85A), early secretory antigenic target (ESAT-6) or IL-2 and to investigate the immunogenicity of these recombinant MVA in mice. Methods The genes encoding Ag85A and ESAT-6 were amplified by PCR from Mycobacterium

  6. Viral vectors for vascular gene therapy

    OpenAIRE

    Fischer, Lukas; Preis, Meir; Weisz, Anat; Koren, Belly; Lewis, Basil S; Flugelman, Moshe Y

    2002-01-01

    Vascular gene therapy is the focus of multiple experimental and clinical research efforts. While several genes with therapeutic potential have been identified, the best method of gene delivery is unknown. Viral vectors have the capacity to transfer genes at high efficiency rates. Several viral-based vectors have been used in experimental vascular gene therapy for in vivo and ex vivo gene transfer. Adenoviral-based vectors are being used for the induction of angiogenesis in phase 1 and 2 clini...

  7. Transforming Vectors Measured By Noncoaligned Instruments

    Science.gov (United States)

    Ritter, James R.; Dahlstrom, Eric L.

    1993-01-01

    Method for computing relationships between coordinate axes of two vector-measuring instruments not aligned with each other, one need only measure two nonparallel vectors u and v simultaneously in both coordinate systems. These measurements provide all data needed to compute transformation of any vector from one coordinate system to other. Particularly useful in computing alignments and transformations between accelerometers, gyroscopes, and instruments mounted on platforms subjected to vibrations, thermal strains, and other distortions causing alignments to vary unpredictably with time.

  8. Possible applications for replicating HIV 1 vectors

    OpenAIRE

    Das, Atze T.; Jeeninga, Rienk E.; Berkhout, Ben

    2010-01-01

    Since its discovery some 25 years ago, much has been learned about HIV type 1 and the molecular details of its replication cycle. This insight has been used to develop lentiviral vector systems that have advantages over conventional retroviral vector systems. For safety reasons, the lentiviral vector systems are replication incompetent and the risk of generating a replication competent virus has been minimized. Nevertheless, there may be certain applications for replication competent HIV base...

  9. An Algorithm for Interpolating Ship Motion Vectors

    OpenAIRE

    Qinyou Hu; F. Cai; Chun Yang; Chaojian Shi

    2014-01-01

    Interpolation of ship motion vectors is able to be used for estimating the lost ship AIS dynamic information, which is important for replaying marine accidents and for analysing marine traffic data. The previous methods can only interpolate ship's position, while not including ship's course and speed. In this paper, vector function is used to express the relationship between the ship's time and space coordinates, and the tangent of the vector function and its change rate are able to express p...

  10. Conformal vector fields on Finsler manifolds

    OpenAIRE

    Szilasi, József; Tóth, Anna

    2011-01-01

    Applying concepts and tools from classical tangent bundle geometry and using the apparatus of the calculus along the tangent bundle projection ('pull-back formalism'), first we enrich the known lists of the characterizations of affine vector fields on a spray manifold and conformal vector fields on a Finsler manifold. Second, we deduce consequences on vector fields on the underlying manifold of a Finsler structure having one or two of the mentioned geometric properties.

  11. Mould Calculus for Hamiltonian Vector Fields

    OpenAIRE

    Cresson, Jacky; Morin, Guillaume

    2008-01-01

    We present the general framework of \\'Ecalle's moulds in the case of linearization of a formal vector field without and within resonances. We enlighten the power of moulds by their universality, and calculability. We modify then \\'Ecalle's technique to fit in the seek of a formal normal form of a Hamiltonian vector field in cartesian coordinates. We prove that mould calculus can also produce successive canonical transformations to bring a Hamiltonian vector field into a normal form. We then p...

  12. Integrated epidemiology for vector-borne zoonoses

    OpenAIRE

    Wardrop, Nicola

    2015-01-01

    The development and application of interventions for the control of vector-borne zoonoses requires broad understanding of epidemiological linkages between vector, animal infection and human infection. However, there are significant gaps in our understanding of these linkages and a lack of appropriate data poses a considerable barrier to addressing this issue. A move towards strengthened surveillance of vectors and disease in both animal and human hosts, in combination with linked human-animal...

  13. Discrete least squares approximation with polynomial vectors

    OpenAIRE

    Van Barel, Marc; Bultheel, Adhemar

    1993-01-01

    We give a solution of a discrete least squares approximation problem in terms of orthogonal polynomial vectors. The degrees of the polynomial elements of these vectors can be different. An algorithm is constructed computing the coefficients of recurrence relations for the orthogonal polynomial vectors. In case the function values are prescribed in points on the real line or on the unit circle variants of the original algorithm can be designed which are an order of magnitude more efficient. Al...

  14. Genetic manipulation of endosymbionts to control vector and vector borne diseases

    Directory of Open Access Journals (Sweden)

    Jay Prakash Gupta

    Full Text Available Vector borne diseases (VBD are on the rise because of failure of the existing methods of control of vector and vector borne diseases and the climate change. A steep rise of VBDs are due to several factors like selection of insecticide resistant vector population, drug resistant parasite population and lack of effective vaccines against the VBDs. Environmental pollution, public health hazard and insecticide resistant vector population indicate that the insecticides are no longer a sustainable control method of vector and vector-borne diseases. Amongst the various alternative control strategies, symbiont based approach utilizing endosymbionts of arthropod vectors could be explored to control the vector and vector borne diseases. The endosymbiont population of arthropod vectors could be exploited in different ways viz., as a chemotherapeutic target, vaccine target for the control of vectors. Expression of molecules with antiparasitic activity by genetically transformed symbiotic bacteria of disease-transmitting arthropods may serve as a powerful approach to control certain arthropod-borne diseases. Genetic transformation of symbiotic bacteria of the arthropod vector to alter the vector’s ability to transmit pathogen is an alternative means of blocking the transmission of VBDs. In Indian scenario, where dengue, chikungunya, malaria and filariosis are prevalent, paratransgenic based approach can be used effectively. [Vet World 2012; 5(9.000: 571-576

  15. Pro jective vector fields on Finsler manifolds

    Institute of Scientific and Technical Information of China (English)

    TIAN Huang-jia

    2014-01-01

    In this paper, we give the equation that characterizes projective vector fields on a Finsler manifold by the local coordinate. Moreover, we obtain a feature of the projective fields on the compact Finsler manifold with non-positive flag curvature and the non-existence of projective vector fields on the compact Finsler manifold with negative flag curvature. Furthermore, we deduce some expectable, but non-trivial relationships between geometric vector fields such as projective, affine, conformal, homothetic and Killing vector fields on a Finsler manifold.

  16. Vector (two-dimensional) magnetic phenomena

    International Nuclear Information System (INIS)

    In this paper, some interesting phenomena were described from the viewpoint of two-dimensional magnetic property, which is reworded with the vector magnetic property. It shows imperfection of conventional magnetic property and some interested phenomena were discovered, too. We found magnetic materials had the strong nonlinearity both magnitude and spatial phase due to the relationship between the magnetic field strength H-vector and the magnetic flux density B-vector. Therefore, magnetic properties should be defined as the vector relationship. Furthermore, the new Barukhausen signal was observed under rotating flux. (Author)

  17. Hermite normal forms and $\\delta$-vector

    OpenAIRE

    Hibi, Takayuki; Higashitani, Akihiro; Li, Nan

    2010-01-01

    Let $\\delta(\\Pc) = (\\delta_0, \\delta_1,..., \\delta_d)$ be the $\\delta$-vector of an integral polytope $\\Pc \\subset \\RR^N$ of dimension $d$. Following the previous work of characterizing the $\\delta$-vectors with $\\sum_{i=0}^d \\delta_i \\leq 3$, the possible $\\delta$-vectors with $\\sum_{i=0}^d \\delta_i = 4$ will be classified. And each possible $\\delta$-vectors can be obtained by simplices. We get this result by studying the problem of classifying the possible integral simplices with a given $\\...

  18. Olfaction in vector-host interactions

    OpenAIRE

    Takken, W; Knols, B.G.J.

    2010-01-01

    This book addresses the topic how blood-feeding arthropods interact with their vertebrate hosts. As the transmission of infectious vector-borne pathogens is much dependent on the contact between vector and host, the efficacy of host location is of profound importance. Interruption of vector-host contact is considered on of the most effective means of vector-borne disease control, as is currently witnessed by the successful use of insecticide-treated bed nets for malaria control in sub-Saharan...

  19. Vector perturbations of galaxy number counts

    CERN Document Server

    Durrer, Ruth

    2016-01-01

    We derive the contribution to relativistic galaxy number count fluctuations from vector and tensor perturbations within linear perturbation theory. Our result is consistent with the the relativistic corrections to number counts due to scalar perturbation, where the Bardeen potentials are replaced with line-of-sight projection of vector and tensor quantities. Since vector and tensor perturbations do not lead to density fluctuations the standard density term in the number counts is absent. We apply our results to vector perturbations which are induced from scalar perturbations at second order and give numerical estimates of their contributions to the power spectrum of relativistic galaxy number counts.

  20. An elusive vector dark matter

    Directory of Open Access Journals (Sweden)

    Chuan-Ren Chen

    2015-02-01

    Full Text Available Even though the sensitivity of direct dark matter search experiments reaches the level of about 10−45 cm2, no confident signal of dark matter has been observed. We point out that, if dark matter is a vector boson, the null result in direct dark matter search experiments may be due to the destructive effects in dark-matter–nucleon elastic scattering. We illustrate the scenario using a modified Higgs portal model that includes exotic quarks. The significant cancellation can occur for a certain mass gap between new heavy quark and dark matter. As a result, the spin-independent dark-matter–nucleon elastic scattering is so suppressed that the future direct search experiments will hardly observe the signal of dark matter.

  1. Vector Boson Scattering at ATLAS

    CERN Document Server

    Ozcan, V E

    2009-01-01

    While the Higgs model is the best studied scenario of electroweak symmetry breaking, there is no fundamental reason for the physics responsible for the symmetry breaking to be weakly-coupled. Many alternatives exist, predicting highly model-dependent signatures. By measuring the cross-section for the W and Z scattering at the LHC, it will be possible to obtain model-independent evidence for strong symmetry breaking or to constrain these various models. ATLAS Collaboration has recently performed a realistic simulation of this process and its backgrounds, which takes into account the detector effects and has developed new jet-analysis techniques for identifying vector bosons within the immense QCD backgrounds expected at the LHC. These techniques and the prospects for measuring the scattering signal will be presented.

  2. Differentially Private Support Vector Machines

    CERN Document Server

    Sarwate, Anand; Monteleoni, Claire

    2009-01-01

    This paper addresses the problem of practical privacy-preserving machine learning: how to detect patterns in massive, real-world databases of sensitive personal information, while maintaining the privacy of individuals. Chaudhuri and Monteleoni (2008) recently provided privacy-preserving techniques for learning linear separators via regularized logistic regression. With the goal of handling large databases that may not be linearly separable, we provide privacy-preserving support vector machine algorithms. We address general challenges left open by past work, such as how to release a kernel classifier without releasing any of the training data, and how to tune algorithm parameters in a privacy-preserving manner. We provide general, efficient algorithms for linear and nonlinear kernel SVMs, which guarantee $\\epsilon$-differential privacy, a very strong privacy definition due to Dwork et al. (2006). We also provide learning generalization guarantees. Empirical evaluations reveal promising performance on real and...

  3. Probing deformed orbitals with vector A( vector e, e' N)B reactions

    International Nuclear Information System (INIS)

    We present results for response functions and asymmetries in the nuclear reactions 37 vector Ar( vector e, e' n)36Ar and 37 vector K( vector e,e' p)36Ar at quasifree kinematics. We compare PWIA results obtained using deformed HF wave functions with PWIA and DWIA results obtained assuming a spherical mean field. We show that the complex structure of the deformed orbitals can be probed by coincidence measurements with polarized beam and targets. ((orig.))

  4. Effects of high-order dispersions on dark-bright vector soliton propagation and interaction

    Institute of Scientific and Technical Information of China (English)

    Hong Li; Dongning Wang

    2011-01-01

    The dynamics of dark-bright vector solitons is investigated in a birefringent fiber with the high-order dispersions, and their effects on vector soliton propagation and interaction are analyzed using the numerical method. The combined role of the high-order dispersions, such as the third-order dispersion (TOD) and the fourth-order dispersion (FOD), may cause various deformation of the vector soliton and enhance interaction. These effects depend strictly on the sign of the high-order dispersions. Results indicate that the disadvantageous effects can be reduced effectively via proper mapping of the high-order dispersions.%@@ The dynamics of dark-bright vector solitons is investigated in a birefringent fiber with the high-order dispersions, and their effects on vector soliton propagation and interaction are analyzed using the numerical method.The combined role of the high-order dispersions, such as the third-order dispersion (TOD) and the fourth-order dispersion (FOD), may cause various deformation of the vector soliton and enhance interaction.These effects depend strictly on the sign of the high-order dispersions.Results indicate that the disadvantageous effects can be reduced effectively via proper mapping of the high-order dispersions.

  5. BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

    Science.gov (United States)

    El Ashkar, Sara; De Rijck, Jan; Demeulemeester, Jonas; Vets, Sofie; Madlala, Paradise; Cermakova, Katerina; Debyser, Zeger; Gijsbers, Rik

    2014-01-01

    Stable integration in the host genome renders murine leukemia virus (MLV)-derived vectors attractive tools for gene therapy. Adverse events in otherwise successful clinical trials caused by proto-oncogene activation due to vector integration hamper their application. MLV and MLV-based vectors integrate near strong enhancers, active promoters, and transcription start sites (TSS) through specific interaction of MLV integrase (IN) with the bromodomain and extra-terminal (BET) family of proteins, accounting for insertional mutagenesis. We identified a BET-interaction motif in the C-terminal tail of MLV IN conserved among gammaretroviruses. By deletion of this motif or a single point mutation (INW390A), BET-independent MLV (BinMLV) were engineered. BinMLV vectors carrying INW390A integrate at wild-type efficiency, with an integration profile that no longer correlates with BET chromatin distribution nor with the traditional markers of MLV integration. In particular, BinMLV vector integration associated less with oncogene TSS compared to the MLV vectors currently used in clinical trials. Together, these findings open perspectives to increase the biosafety of gammaretroviral vectors for gene therapy. PMID:25072693

  6. Ankara İli Merkez İlçede Bireylerin Gazlı İçecek Tüketimine İlişkin Bir Değerlendirme

    OpenAIRE

    Bilge Gözener; Murat Sayılı

    2015-01-01

    Bu araştırmada, Ankara ili Merkez ilçede (Çankaya, Etimesgut, Gölbaşı, Keçiören, Mamak, Polatlı, Sincan ve Yenimahalle ilçeleri) tüketicilerin gazlı içecek tüketim durumları incelenmiştir. Araştırmada 272 aileden anket yolu ile elde edilen veriler kullanılmıştır. Veriler Nisan-Mayıs-2012 yılına aittir. Tüketicilerin bazı demografik özellikleri ile gazlı içecek tüketimleri arasında istatistiksel bir ilişki olup olmadığı ki-kare analizi ile test edilmiştir. Araştırma sonuçlarına göre; ailelerin...

  7. Design and simulation of 3½-cell superconducting gun cavity and beam dynamics studies of the SASE-FEL System at the Institute of Accelerator Technologies at Ankara University

    International Nuclear Information System (INIS)

    Design and simulation of a superconducting gun cavity with 3½ cells have been studied in order to give the first push to the electron beam for the linear accelerating system at The Institute of Accelerator Technologies at Ankara University. Electrons are accelerated through the gun cavity with the help of the Radiofrequency power suppliers from cryogenic systems. Accelerating gradient should be as high as possible to accelerate electron beam inside the cavity. In this study, electron beam reaches to 9.17 MeV energy at the end of the gun cavity with the accelerating gradient; Ec=19.21 MV/m. 1.3 GHz gun cavity consists of three TESLA-like shaped cells while the special designed gun-cell includes a cathode plug. Optimized important beam parameters inside the gun cavity, average beam current 3 mA, transverse emittance 2.5 mm mrad, repetition rate 30 MHz and other parameters are obtained for the SASE-FEL System. The Superfish/Poisson program is used to design each cell of the superconducting cavity. Superconducting gun cavity and Radiofrequency properties are studied by utilizing 2D Superfish/Poisson, 3D Computer Simulation Technology Microwave Studio, and 3D Computer Simulation Technology Particle Studio. Superfish/Poisson is also used to optimize the geometry of the cavity cells to get the highest accelerating gradient. The behavior of the particles along the beamline is included in this study. ASTRA Code is used to track the particles

  8. Late Jurassic-Early Cretaceous radiolarian age constraints from the sedimentary cover of the Amasia ophiolite (NW Armenia), at the junction between the Izmir-Ankara-Erzinçan and Sevan-Hakari suture zones

    Science.gov (United States)

    Danelian, T.; Asatryan, G.; Galoyan, Gh.; Sahakyan, L.; Stepanyan, J.

    2016-01-01

    The Amasia ophiolite, situated at the northernmost corner of Armenia, is part of the Sevan-Hakari suture zone which links with the Izmir-Ankara-Erzinçan suture zone in northern Turkey. Three new radiolarian assemblages have been extracted from siliceous sedimentary rocks that accumulated on the Amasia ophiolite in an oceanic setting. Two of these assemblages were extracted from red-brownish bedded cherts overlying basaltic lavas; one of these is likely to be middle Oxfordian to early Kimmeridgian in age, while the second correlates with the Berriasian. Similar time-equivalent lava-chert sequences have been dated recently using radiolarians from the Stepanavan, Vedi and Sevan ophiolite units, where they are considered to relate to submarine volcanic activity in the back-arc marginal basin in which the Armenian ophiolites were formed. The third radiolarian assemblage, of late Barremian age, was extracted from a more than 15-m-thick volcaniclastic-chert sequence. The related volcanic activity is likely to have been subaerial and probably relates to the formation of an oceanic volcanic plateau; no Cretaceous subaerial volcanism has been previously recorded in the Lesser Caucasus area.

  9. Design and simulation of 3½-cell superconducting gun cavity and beam dynamics studies of the SASE-FEL System at the Institute of Accelerator Technologies at Ankara University

    Science.gov (United States)

    Yildiz, H. Duran; Cakir, R.; Porsuk, D.

    2015-06-01

    Design and simulation of a superconducting gun cavity with 3½ cells have been studied in order to give the first push to the electron beam for the linear accelerating system at The Institute of Accelerator Technologies at Ankara University. Electrons are accelerated through the gun cavity with the help of the Radiofrequency power suppliers from cryogenic systems. Accelerating gradient should be as high as possible to accelerate electron beam inside the cavity. In this study, electron beam reaches to 9.17 MeV energy at the end of the gun cavity with the accelerating gradient; Ec=19.21 MV/m. 1.3 GHz gun cavity consists of three TESLA-like shaped cells while the special designed gun-cell includes a cathode plug. Optimized important beam parameters inside the gun cavity, average beam current 3 mA, transverse emittance 2.5 mm mrad, repetition rate 30 MHz and other parameters are obtained for the SASE-FEL System. The Superfish/Poisson program is used to design each cell of the superconducting cavity. Superconducting gun cavity and Radiofrequency properties are studied by utilizing 2D Superfish/Poisson, 3D Computer Simulation Technology Microwave Studio, and 3D Computer Simulation Technology Particle Studio. Superfish/Poisson is also used to optimize the geometry of the cavity cells to get the highest accelerating gradient. The behavior of the particles along the beamline is included in this study. ASTRA Code is used to track the particles.

  10. Design and simulation of 3½-cell superconducting gun cavity and beam dynamics studies of the SASE-FEL System at the Institute of Accelerator Technologies at Ankara University

    Energy Technology Data Exchange (ETDEWEB)

    Yildiz, H. Duran, E-mail: hdyildiz@ankara.edu.tr [Institute of Accelerator Technologies, Ankara University, Ankara (Turkey); Cakir, R. [Nanotechnology Engineering Department, Recep Tayyip Erdogan University, Rize (Turkey); Porsuk, D. [Physics Department, Dumlupinar University, Kutahya (Turkey)

    2015-06-11

    Design and simulation of a superconducting gun cavity with 3½ cells have been studied in order to give the first push to the electron beam for the linear accelerating system at The Institute of Accelerator Technologies at Ankara University. Electrons are accelerated through the gun cavity with the help of the Radiofrequency power suppliers from cryogenic systems. Accelerating gradient should be as high as possible to accelerate electron beam inside the cavity. In this study, electron beam reaches to 9.17 MeV energy at the end of the gun cavity with the accelerating gradient; E{sub c}=19.21 MV/m. 1.3 GHz gun cavity consists of three TESLA-like shaped cells while the special designed gun-cell includes a cathode plug. Optimized important beam parameters inside the gun cavity, average beam current 3 mA, transverse emittance 2.5 mm mrad, repetition rate 30 MHz and other parameters are obtained for the SASE-FEL System. The Superfish/Poisson program is used to design each cell of the superconducting cavity. Superconducting gun cavity and Radiofrequency properties are studied by utilizing 2D Superfish/Poisson, 3D Computer Simulation Technology Microwave Studio, and 3D Computer Simulation Technology Particle Studio. Superfish/Poisson is also used to optimize the geometry of the cavity cells to get the highest accelerating gradient. The behavior of the particles along the beamline is included in this study. ASTRA Code is used to track the particles.

  11. İş tatmini ile stres düzeyleri ilişkisi: Ankara Gölbaşı Hasvak Devlet Hastanesi ve Kalecik Devlet Hastaneleri örneği

    OpenAIRE

    ARIZ, Tuğba

    2010-01-01

    Bu araştırma Ankara Gölbaşı Hasvak ile Kalecik Devlet Hastanelerinde görev yapan hastane personelinin iş tatmini ve stres düzeyleri arasındaki ilişkinin belirlenmesi amacıyla yapılmıştır. Araştırma kapsamına hastanede çalışan tüm personel dahil edilmiştir. Toplamda 276 personele anket uygulanmıştır. Evrenin % 86'sına ulaşılmıştır. Veriler anket yöntemiyle yüz yüze görüşme tekniğiyle elde edilmiştir. Uygulama Eylül 2009 tarihlerinde yapılmıştır. İş tatminini belirleyebilme...

  12. Ankara Piyasasında Satılan Ayran ve Yoğurt Örneklerinin Hijyenik Kaliteleri Üzerinde Araştırmalar

    OpenAIRE

    Duru, Suna; Özgüneş, Hilal

    1981-01-01

    Birçok ülkede süt ve süt ürünleri kişinin diyetinin önemli bir bölümünü oluşturmaktadır. Bu gıda maddelerinin hastalık taşıma potansiyeli yüksek olduğundan, hijyenik kalitelerine özen gösterilmesi gerekir. Bu çalışmada, yurdumuzda büyük ölçüde tüketilen ürünlerden ayran ve yoğurt, hijyenik kaliteleri yönünden incelendi. 9 Haziran-14 Ağustos 1979 tarihleri arasında çeşitli zamanlarda Ankara piyasasından toplanan 50 ayran ve 20 yoğurt örneğinde koliform bakteri sayımı, 40 ayran ve 20 yoğurt ö...

  13. T. C. Kültür ve Turizm Bakanlığı Ankara Devlet Klâsik Türk Müziği Korosunun Repertuarının İncelenmesi

    OpenAIRE

    Kaynarca, Burak

    2005-01-01

    Bu çalışmada, ülkemizin kültür ve sanat hayatının en yetkin kurumlarından olan Kültür ve Turizm Bakanlığı Ankara Devlet Klâsik Türk Müziği Korosunun kuruluşundan bu yana gerçekleştirilmiş tüm konser repertuarları incelenmiş, seçilen repertuarlarda hangi dönem Türk Mûsikîsi eserlerine ağırlık verildiği, en çok hangi formdan eserlerin tercih edildiği saptanmıştır. Ayrıca Kültür ve Turizm Bakanlığına bağlı Güzel Sanatlar Müdürlüğünün ve ona bağlı Türk Müziği Korolarının kuruluş amaçları ve günüm...

  14. ANKARA EKOLOJİK KOŞULLARINDA FARKLI AYÇİÇEĞİ (Helianthus annuus L.) ÇEŞİTLERİNİN VERİM PERFORMASLARININ BELİRLENMESİ

    OpenAIRE

    BAYRAMİN, Suay; KAYAÇETİN, Fatma; Arslan, Yusuf; KATAR, Duran

    2012-01-01

    Bu çalışma, 2009 yılında Ankara/Haymana ekolojik koşullarında yürütülmüştür. Çalışmada, 7 farklı hibrit ayçiçeği çeşidi (A71, M69, Califa, Oleko, Oliva, Sanay ve Sanbro) tohumu materyal olarak kullanılmıştır. Denemede; bitki boyu (cm), tabla çapı (cm), tohum verimi (kg/da), yağ oranı (%) ve yağ verimi (kg/da) belirlenmiştir. Araştırmada, çeşitlere bağlı olarak bitki boylarının 101,77 – 127,53 cm, tabla çaplarının 12,67 -14,57 cm, tohum veriminin 135,5 – 240,6 kg/da, yağ oranını % 36,83 – 46,...

  15. Lentiviral vectors in neurodegenrative disorders - Aspects in gene therapy and disease models

    DEFF Research Database (Denmark)

    Nielsen, Troels Tolstrup

    2009-01-01

    , which is most often only satisfactory in the initial phase of the disease. Gene therapy is a novel treatment strategy intended to treat or alleviate disease by genetically modifying cells by introducing nucleic acids into the cells. Lentiviral vectors hold great promise as gene transfer vectors and are...... able to transduce post-mitotic cells e.g. terminally differentiated neurons, making them ideal candidates for gene transfer to the brain and as experimental tools. In this study vectors expressing miRNA embedded shRNA from pol II-promoters were constructed for RNA interference (RNAi) in vitro and in...... vivo. Robust gene knock-down was shown using a ubiquitous promoter (CMV) and for the first time neuron specific RNAi was obtained using a neuron specific promoter (NSE). Furthermore, optimization of lentiviral vectors was conducted using an insulator element (cHS4) in order to enhance transgene...

  16. Improved support vectors for classification through preserving neighborhood geometric structure constraint

    Science.gov (United States)

    Wang, Xuchu; Niu, Yanmin

    2011-08-01

    The support vector machine (SVM) has become a popular classifier in pattern recognition, computer vision, and other fields. Traditional SVM may result in a nonrobust solution for classifying complex data because its separating hyperplane only reflects the marginal distance information of isolated support vectors, while discarding some useful class structural information. In this paper a new support vector classifier with neighborhood preserving constraint is proposed to enhance the support vectors by preserving the local geometric structure on the manifold of within-class samples. This structure can be represented as a weighted graph matrix and regulated by adding a preprocessing transform in standard SVM. Experimental results validate its effectiveness with comparison to related methods on several synthetic and real-world data sets and show its competence, especially for classifying high dimensional data in a small sample size case.

  17. Deep Support Vector Machines for Regression Problems

    NARCIS (Netherlands)

    Wiering, Marco; Schutten, Marten; Millea, Adrian; Meijster, Arnold; Schomaker, Lambertus

    2013-01-01

    In this paper we describe a novel extension of the support vector machine, called the deep support vector machine (DSVM). The original SVM has a single layer with kernel functions and is therefore a shallow model. The DSVM can use an arbitrary number of layers, in which lower-level layers contain su

  18. Partitioning Hadamard vectors into Hadamard matrices

    OpenAIRE

    Casazza, Peter G.; Tremain, Janet C.

    2016-01-01

    We will show that in a space of dimension $m$, any family of $2^{m-1}$ distinct Hadamard vectors (where you can choose x or -x but not both) can be partitioned into Hadamard matrices if and only if $m=2^n$ for some n. We will solve this problem with a simple algorithm for assigning the vectors to the Hadamard matrices.

  19. Application of Vectors to Relative Velocity

    Science.gov (United States)

    Tin-Lam, Toh

    2004-01-01

    The topic 'relative velocity' has recently been introduced into the Cambridge Ordinary Level Additional Mathematics syllabus under the application of Vectors. In this note, the results of relative velocity and the 'reduction to rest' technique of teaching relative velocity are derived mathematically from vector algebra, in the hope of providing…

  20. Vector particles tunneling from BTZ black holes

    CERN Document Server

    Chen, Ge-Rui; Huang, Yong-Chang

    2014-01-01

    In this paper we investigate vector particles' Hawking radiation from a BTZ black hole. By applying the WKB approximation and the Hamilton-Jacobi Ansatz to the Proca equation, we obtain the tunneling spectrum of vector particles. The expected Hawking temperature is recovered.