WorldWideScience

Sample records for andrzej gospodarowitcz ewa

  1. Karakterisering van het Etimologiewoordeboek van Afrikaans (EWA

    Directory of Open Access Journals (Sweden)

    Fons Moerdijk

    2011-10-01

    Full Text Available

    Samenvatting: Zesendertig jaar na Afrikaanse etimologieë van Boshoff en Nienaber verscheener in 2003 een nieuw etymologisch woordenboek van het Afrikaans: het Etimologiewoordeboek vanAfrikaans (EWA. Tussen die twee woordenboeken bestaat een wezenlijk verschil. Het werk vanBoshoff en Nienaber is vrijwel alleen toegankelijk voor specialisten en niet specifiek bedoeld vooreen breed publiek. EWA is juist allereerst bestemd voor de leek die zich interesseert voor de oorsprongen de geschiedenis van de eigen taal. Daarnaast biedt het ook de etymoloog en historischtaalkundige een hoop gegevens en inspiratie voor nader onderzoek. Als etymologisch woordenboekbezit EWA een aantal bijzondere, eigen kenmerken. De selectie van de woorden is bepaalddoor het beoogde gebruikerspubliek. Als gevolg daarvan bevat EWA verscheidene typen woordendie in traditionele etymologische woordenboeken doorgaans veronachtzaamd worden, zoals afleidingen,samenstellingen, neologismen en gemeenzame spreektaalwoorden. De artikelstructuurwordt gekenmerkt door een hoge graad van uniformiteit en consistentie. Het accent ligt op dezogenaamde etymologia proxima, de etymologie waarbij men één stap teruggaat en de meestdirecte herkomst van het woord biedt. Voorts is speciale aandacht besteed aan polysemie: nietalleen de herkomst van de dominante betekenis van een woord wordt gegeven, maar ook die vanzijn eventuele andere betekenis(sen. Benoemingsmotieven komen ook veelvuldig aan bod. In eeneventuele tweede druk zouden opvallende verschillen in vorm of betekenis altijd verklaard of inieder geval besproken moeten worden. Dat blijft nu nogal eens achterwege. Ook zou voorafgaandaan zo'n volgende editie meer onderzoek naar woordhistorisch materiaal uit primaire bronnenvoor met name de 17de–19de eeuw verricht moeten worden. Het zou mooi zijn als deze eersteuitgave van EWA de aanleiding tot een dergelijk onderzoek zou vormen.

    Sleutelwoorden: BENOEMINGSMOTIEF, ETYMOLOGIA PROXIMA

  2. Quantification of clay minerals by combined EWA/XRD method

    Institute of Scientific and Technical Information of China (English)

    XU; Jianhong; (徐建红); XU; Jianhong; (徐建红); T.; R.; Astin; PAN; Mao; (潘懋)

    2001-01-01

    Illite has been considered the main constraint on permeability in the Morecambe Gas Field, East Irish Sea, UK. Previous research has emphasized the morphology rather than the amount of clay minerals. By applying a new method of clay mineral quantification, EWA/XRD, and applying statistical analysis methods, we are able to establish a quantitative model of illite distribution in the field. The result also leads to a better understanding of permeability distribution in reservoir sandstones.

  3. Andrzej Wajda : maailm küll teadis, aga ei hoolinud / Eda Post

    Index Scriptorium Estoniae

    Post, Eda, 1983-

    2008-01-01

    Poola filmi- ja teatrilavastaja Andrzej Wajda, kes pälvis sel aastal president Toomas Hendrik Ilveselt Maarjamaa Risti III klassi teenetemärgi. Tema viimasest mängufilmist "Katõn". Lisatud andmed elu ja töö kohta. Ordenit vastu võtma A. Wajda ei tule, sest 24. veebruaril 2008 läheb ta Los Angeleses Oscarite galale, kus tema film "Katõn" on parima võõrkeelse filmi auhinna nominent

  4. The work of Professor Andrzej Lasota on asymptotic stability and recent progress

    Directory of Open Access Journals (Sweden)

    Wojciech Bartoszek

    2008-01-01

    Full Text Available The paper is devoted to Professor Andrzej Lasota's contribution to the ergodic theory of stochastic operators. We have selected some of his important papers and shown their influence on the evolution of this topic. We emphasize the role A. Lasota played in promoting abstract mathematical theories by showing their applications. The article is focused exclusively on ergodic properties of discrete stochastic semigroups \\(\\{P^n : n \\geq 0\\}\\. Nevertheless, almost all of Lasota's results presented here have their one-parameter continuous semigroup analogs.

  5. Uncertainty in vertical extrapolation of wind statistics: shear-exponent and WAsP/EWA methods

    DEFF Research Database (Denmark)

    Kelly, Mark C.

    for uncertainties inherent in determination of (wind) shear exponents, and subsequent vertical extrapolation of wind speeds. The report further outlines application of the theory and results of Kelly & Troen (2014-6) for gauging the uncertainty inherent in use of the European Wind Atlas (EWA) / WAsP method...

  6. French fashion during the German occupation in the dairy of Andrzej Bobkowski 1940 -1944

    Directory of Open Access Journals (Sweden)

    Krzysztof Trojanowski

    2015-12-01

    Full Text Available Blocked in Paris in 1939 en route to South America, Andrzej Bobkowski (1913-1961, Polish writer and essayist, holds a diary during the period of German occupation. This document of great value, published in French in 1991, is rich in cultural, philosophical and literary references. It also provides fascinating details and observations on daily life of Parisians under the Nazi boot where fashion and elegance every day become a sort of aesthetic response to the situation and a patriotic duty. Fantasy hats and wooden soled shoes, rabbit furs and couture dresses, skirts for cyclists and legs painted due to the lack of silk stockings – French fashion dark years succeeded in combining creativity, comfort and chic to remain faithful to the ideal of beauty and femininity.

  7. Measuring surface-water loss in Honouliuli Stream near the ‘Ewa Shaft, O‘ahu, Hawai‘i

    Science.gov (United States)

    Rosa, Sarah N.

    2017-05-30

    The Honolulu Board of Water Supply is currently concerned with the possibility of bacteria in the pumped water of the ‘Ewa Shaft (State well 3-2202-21). Groundwater from the ‘Ewa Shaft could potentially be used to meet future potable water needs in the ‘Ewa area on the island of O‘ahu. The source of the bacteria in the pumped water is unknown, although previous studies indicate that surface water may be lost to the subsurface near the site. The ‘Ewa Shaft consists of a vertical shaft, started near the south bank of Honouliuli Stream at an altitude of about 161 feet, and two horizontal infiltration tunnels near sea level. The shaft extracts groundwater from near the top of the freshwater lens in the Waipahu-Waiawa aquifer system within the greater Pearl Harbor Aquifer Sector, a designated Water Management Area.The surface-water losses were evaluated with continuous groundwater-level data from the ‘Ewa Shaft and a nearby monitoring well, continuous stream-discharge data from U.S. Geological Survey streamflow-gaging station 16212490 (Honouliuli Stream at H-1 Freeway near Waipahu), and seepage-run measurements in Honouliuli Stream and its tributary. During storms, discharge at the Honouliuli Stream gaging station increases and groundwater levels at ‘Ewa Shaft and a nearby monitoring well also increase. The concurrent increase in water levels at ‘Ewa Shaft and the nearby monitoring well during storms indicates that regional groundwater-level changes related to increased recharge, reduced withdrawals (due to a decrease in demand during periods of rainfall), or both may be occurring; although these data do not preclude the possibility of local recharge from Honouliuli Stream. Discharge measurements from two seepage runs indicate that surface water in the immediate area adjacent to ‘Ewa Shaft infiltrates into the streambed and may later reach the groundwater system developed by the ‘Ewa Shaft. The estimated seepage loss rates in the vicinity of ‘Ewa

  8. Professor Andrzej Budzanowski, Director General, Henryk Niewodniczanski Institute of Nuclear Physics (HNINP) Poland. Dr. Grzegorz Polok, Deputy Director

    CERN Multimedia

    Maximilien Brice

    2003-01-01

    Andrzej Budzanowski, Director-General of the Cracow Institute of Nuclear Physics (HNINP) and Lyn Evans, LHC Project Leader, signing the collaboration agreement. In the background, from leftto right : Grzegorz Polok, Deputy Director-General of the Cracow Institute of Nuclear Physics, Blazej Skoczen, in charge of the LHC cryomagnet interconnections, Claude Détraz, Director for Fixed Target and Future Programmes, Alain Poncet, AT/CRI Group Leader.

  9. A Film Study of Loneliness. About “Tatarak” by Andrzej Wajda

    Directory of Open Access Journals (Sweden)

    Małgorzata Okupnik

    2014-04-01

    Full Text Available Andrzej Wajda has often taken up the topic of loneliness. In the screen adaptation of “Tatarak” (2009 he showed the loneliness of a married couple in the face of death and serious illness. The director used two stories: “Tatarak” by J. Iwaszkiewicz and “The sudden call” by S. Marai. The most important plot of the film is the private confession of the actress Krystyna Janda, who had recently lost her husband. In the analysis of the film by Wajda the philosophical concept mimesis may be used. Paul Ricoeur in “Time and Narration” claims that mimesis is not a homogeneous category and distinguishes three variations of it. Behind the three types of mimesis of “Tatarak,” lie different meanings of loneliness. In mimesis III two worlds overlap: the world of the artist and the world of the audience. Janda’s narration leads to an active understanding of what the experience of loss and loneliness is and crystallizes it. The story about loss and loneliness is also a form of therapy for her.

  10. Cultural experience in the poetry of Ewa Lipska (Outline of the problems

    Directory of Open Access Journals (Sweden)

    Anna Legeżyńska

    2011-01-01

    Full Text Available The author pays attention to the need to search new keys of interpretation of the ouevre of Ewa Lipska, recognising that the constant distinguishing feature is the anthropological aspect. The main thesis of the article is as follows: Lipska’s poetry may be treated as a particularly important evidence of cultural experiences. Also attention is focused by the author on the poetic phenomenology of sensual perception, its reflection in the awareness and memory of the subject, and also distinguishes “cultural memory” as an effect of experience. She also states that Ewa Lipska’s works are a criticism of culture – both of the so called PRL’s (Polish People’s Republic’s culture and the later one, called the postmodern culture. The poet exposes myths and threats of post-modernity, however, the cultural experience as recorded in her works is of ambivalent character: on the one hand, it contains a negative feeling of domination of man’s existence by cyberculture, and on the other, shows the deepening and sharpening of the critical awareness of the subject, who defends himself against the inauthenticity of experience.

  11. An Environment-Wide Association Study (EWAS on type 2 diabetes mellitus.

    Directory of Open Access Journals (Sweden)

    Chirag J Patel

    Full Text Available BACKGROUND: Type 2 Diabetes (T2D and other chronic diseases are caused by a complex combination of many genetic and environmental factors. Few methods are available to comprehensively associate specific physical environmental factors with disease. We conducted a pilot Environmental-Wide Association Study (EWAS, in which epidemiological data are comprehensively and systematically interpreted in a manner analogous to a Genome Wide Association Study (GWAS. METHODS AND FINDINGS: We performed multiple cross-sectional analyses associating 266 unique environmental factors with clinical status for T2D defined by fasting blood sugar (FBG concentration > or =126 mg/dL. We utilized available Centers for Disease Control (CDC National Health and Nutrition Examination Survey (NHANES cohorts from years 1999 to 2006. Within cohort sample numbers ranged from 503 to 3,318. Logistic regression models were adjusted for age, sex, body mass index (BMI, ethnicity, and an estimate of socioeconomic status (SES. As in GWAS, multiple comparisons were controlled and significant findings were validated with other cohorts. We discovered significant associations for the pesticide-derivative heptachlor epoxide (adjusted OR in three combined cohorts of 1.7 for a 1 SD change in exposure amount; p<0.001, and the vitamin gamma-tocopherol (adjusted OR 1.5; p<0.001. Higher concentrations of polychlorinated biphenyls (PCBs such as PCB170 (adjusted OR 2.2; p<0.001 were also found. Protective factors associated with T2D included beta-carotenes (adjusted OR 0.6; p<0.001. CONCLUSIONS AND SIGNIFICANCE: Despite difficulty in ascertaining causality, the potential for novel factors of large effect associated with T2D justify the use of EWAS to create hypotheses regarding the broad contribution of the environment to disease. Even in this study based on prior collected epidemiological measures, environmental factors can be found with effect sizes comparable to the best loci yet found by GWAS.

  12. Agnieszka, Antigone: The Antigone Myth in Andrzej Wajda’s Katyn and in Dominik Smole’s Antigona

    Directory of Open Access Journals (Sweden)

    Andreja N. Inkret

    2010-12-01

    Full Text Available The article considers two modern works which employ the Antigone myth. The Polish film director Andrzej Wajda included several implicit allusions to the myth in his Katyn (2007,a film about the mass murder of Polish officers and intelligentsia – a Soviet crime which remained a taboo for almost half a century. On the other hand, Dominik Smole, a Slovenian playwright, wrote a play about Antigone (1960, which is set from beginning to end in ancient Thebes. It has been suggested that his play indirectly calls attention to the Slovenian post-war killings of the Slovenian Home Guard members, which were likewise long tabooed. Inquiring how the two works relate to Sophocles’ Antigone, the article points out that Andrzej Wajda seems inspired not only by Sophocles’ ideas but also by his dramatic techniques. A scene that seems especially interesting in this respect presents Agnieszka (Antigone going to the theatre to sell her hair in order to buy a tombstone for her dead brother Piotr (Polyneikes. The action in the theatre is so full of metaphors and subtle imagery that it can be compared to one of the most compelling scenes in Sophocles’ Antigone (801—943. In the latter, Sophocles employs a popular ancient dramatic technique, incorporating ritual elements in the dramatic action in order to create an atmosphere rich in meanings and connotations. While Wajda’s film includes at least two other scenes which seem directly inspired by the dramaturgical composition of Sophocles’ tragedy, Dominik Smole does not appear to make much use of Sophoclean techniques. To both authors, however, Sophocles is a key reference for their characters, situations, and dilemmas; both the film and the play refer to the ancient tragedy either through similarities or differences established in relation to the ancient Antigone. With regard to the differences, Smole’s only new persona dramatis, the page who survives Antigone as her devoted follower, appears to be

  13. Fish Census Data from Annual Surveys at Selected Shallow-water Sites Near the Barber's Point Sewage Outfall, Ewa, Oahu, Hawaii, 1991 - 2010 (NODC Accession 0073346)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Honouliuli Wastewater Treatment Plant (WWTP) located in Ewa, Oahu, Hawaii, near Barbers Point (Kalaeloa) has been in operation since 1982. It releases...

  14. Signature of a Collaboration Agreement between The Andrzej Soltan Institute for Nuclear Studies (IPJ) and CERN, by Prof. Grzegorz Wrochna, Director and CERN Director-General, concerning Collaboration in the LHC upgrade.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    Signature of a Collaboration Agreement between The Andrzej Soltan Institute for Nuclear Studies (IPJ) and CERN, by Prof. Grzegorz Wrochna, Director and CERN Director-General, concerning Collaboration in the LHC upgrade.

  15. Threats or Victims: The Ambiguous Nature of Supernatural Creatures in Andrzej Sapkowski’s and George R. R. Martin’s Fantasy

    OpenAIRE

    Piven, Sviatoslav

    2015-01-01

    Many postcolonial readings of fantasy fiction focus on exploring complicated relationships between different fantastic races that inhabit a certain secondary world. However, such studies often overlook interactions of these races with the supernatural animals and beasts that live alongside them. Fantasy narratives like Andrzej Sapkowski’s The Witcher Saga and George R. R. Martin’s A Song of Ice and Fire depict fantastic settings where the relationship between the inhabitants of...

  16. The Problem of Rights and Freedom in Andrzej Frycz Modrzewski’s "Commentariorum de Republica emendanda libri quinque"

    Directory of Open Access Journals (Sweden)

    Joanna Marszk

    2015-12-01

    Full Text Available The subject of this article is the problem of rights and freedom in Andrzej Frycz Modrzewski’s "Commentariorum de Republica emendanda libri quinque". It sets out to show how the author sets out the two categories and construes the relations between them. Initially, it aims to highlight the general sources of thinking about rights and freedom in Central Europe, while at the same time offering a broad profile of Modrzewski in the light of his epoch. The main part of the article then presents a selection of ideas taken from his well-known work. It presents his conception of custom as the ground of law, and his furnishing of arguments for the existence of written laws. It distinguishes two criteria by means of which Modrzewski sought to evaluate laws: reason and justice. It outlines the negative aspects of certain acts, the worst of which is murder and its associated problems. His view concerning the incorrect treatment of serfs is also presented, together with his criteria for the selection of officials. This is followed by his innovatory project for reform of the judicial system, in which the key point is the establishment of permanent courts. Modrzewski’s attitude to the issue of freedom, with its distinction between inner and outer freedom, is then explored, emphasizing the inseparable character of the connection between the two concepts. Finally, the distinctively Polish character of the perspective presented is highlighted.

  17. Poetry of Life / Poetry of Instruction: poems by Andrzej Sosnowski in the Context of Ezra Pound’s Theory of Poetry

    Directory of Open Access Journals (Sweden)

    Wit Pietrzak

    2013-01-01

    Full Text Available In the present article Andrzej Sosnowski’s poems is analysed against the theoretical principles elaborated by Ezra Pound. Pound’s postulates such as the ideogrammic method and the melo-, fano-, and logopoeia, all of which are briefly discussed, are used to characterise Sosnowski’s poetic practice. The article shows that, irreducible differences notwithstanding, both poets write in accordance with a set of similar principles. The difference between Sosnowski’s poems and Pound’s Cantos consists mainly in the fact that the former gives up on the inherently Poundian desire to reorganise reality in an epic work and seeks what may be termed a scene of voice on which one’s ownmost identity can be manifested. It is among the many discourses that comprise poems that a voice of life sounds in all its complexity and fragility.

  18. New Nordic Exceptionalism: Jeuno JE Kim and Ewa Einhorn's The United Nations of Norden and other realist utopias

    Directory of Open Access Journals (Sweden)

    Mathias Danbolt

    2016-11-01

    Full Text Available At the 2009 Nordic Culture Forum summit in Berlin that centered on the profiling and branding of the Nordic region in a globalized world, one presenter stood out from the crowd. The lobbyist Annika Sigurdardottir delivered a speech that called for the establishment of “The United Nations of Norden”: A Nordic union that would gather the nations and restore Norden's role as the “moral superpower of the world.” Sigurdardottir's presentation generated such a heated debate that the organizers had to intervene and reveal that the speech was a performance made by the artists Jeuno JE Kim and Ewa Einhorn. This article takes Kim and Einhorn's intervention as a starting point for a critical discussion of the history and politics of Nordic image-building. The article suggests that the reason Kim and Einhorn's speech passed as a serious proposal was due to its meticulous mimicking of two discursive formations that have been central to the debates on the branding of Nordicity over the last decades: on the one hand, the discourse of “Nordic exceptionalism,” that since the 1960s has been central to the promotion of a Nordic political, socio-economic, and internationalist “third way” model, and, on the other hand, the discourse on the “New Nordic,” that emerged out of the New Nordic Food-movement in the early 2000s, and which has given art and culture a privileged role in the international re-fashioning of the Nordic brand. Through an analysis of Kim and Einhorn's United Nations of Norden (UNN-performance, the article examines the historical development and ideological underpinnings of the image of Nordic unity at play in the discourses of Nordic exceptionalism and the New Nordic. By focusing on how the UNN-project puts pressure on the role of utopian imaginaries in the construction of Nordic self-images, the article describes the emergence of a discursive framework of New Nordic Exceptionalism.

  19. EWA Detection Effectiveness Based on SEA Method%基于效能分析方法的预警机探测效能研究

    Institute of Scientific and Technical Information of China (English)

    粘松雷; 严建钢; 林云

    2012-01-01

    在预警机巡逻航线分析的基础上,运用系统效能分析的基本原理,对跑道型巡逻航线探测效能问题进行了研究,重点研究了强效区的探测模型和弱效区的系统映射模型.通过算例仿真对模型的各个因素的影响效果进行了分析.%Based on early warning aircraft(EWA) cruising course analysis, the detection effectiveness cruising along racetrack is studied by using the basic principle of system effecectivess analysis ( SEA ) , The detection model of areas of high probability and system mapping of areas of low probability are specially studied. The influence effect of each factor of the model is analyzed with simulation calculation.

  20. Speakers at CERN's LEP celebration on 9 October 2000 - L. to r. : M. Philippe Busquin, Commissioner for Research European Union; Prof. Marino Gago, Minister of Science and Technology Portugal; Prof. Dimitar Dimitrov, Minister of Education and Science Bulgaria; M. Lubomir Fogas, Deputy Prime Minister Slovak Republic and Prof. Andrzej Wiszniewski Minister of Science Poland : during the LEP celebration.

    CERN Document Server

    Laurent Guiraud

    2000-01-01

    Speakers at CERN's LEP celebration on 9 October 2000 - L. to r. : M. Philippe Busquin, Commissioner for Research European Union; Prof. Marino Gago, Minister of Science and Technology Portugal; Prof. Dimitar Dimitrov, Minister of Education and Science Bulgaria; M. Lubomir Fogas, Deputy Prime Minister Slovak Republic and Prof. Andrzej Wiszniewski Minister of Science Poland : during the LEP celebration.

  1. Are they still among us? Discussion with the book "Rosyjski sztylet. Działalność wywiadu nielegalnego" (The Russian Dagger. Activities of illegal intelligence by Andrzej Kowalski

    Directory of Open Access Journals (Sweden)

    Dominik Smyrgała

    2015-12-01

    Full Text Available The article discusses some of the theses presented in Rosyjski sztylet. Działalność wywiadu nielegalnego by Col. Andrzej Kowalski. The former director of the Polish Military Counterintelligence Service presents the most important aspects of the illegal intelligence of the former USSR. On that foundation, he analyzes media and news about the contemporary intelligence activities of the Russian Federation. He concludes that the use of illegal intelligence is still an important element of the Russian strategy and poses an underappreciated threat to the West. The book is not free of mistakes, namely that some statements cannot be confirmed by the sources. Nevertheless, it is a valuable research perspective; it’s greatest value being the practical knowledge and experience of the author.

  2. 1.0. B. Ewa

    African Journals Online (AJOL)

    Key words: Nigerian Soils, Darcy 's equation, infiltration, kO-standardization, neutron. Activation analysis .... Equation 2 is a non-linear partial differential equation and can ... ordinary differential equation. ..... Soils in Our Environment, Prentice-.

  3. Andrzej Krzysztof Tarkowski abroad, in photos and correspondence.

    Science.gov (United States)

    Graham, Chris F

    2008-01-01

    An informal account records the remaining traces of Tarkowski's research visits to the United Kingdom and France. The account has many authors and it should not be regarded as an exact history. The early 1960s began with the dramatic production of chimaeras at the University of Bangor and the long term exchange of information with Anne McLaren's Edinburgh laboratory. The techniques of parthenogenesis and nuclear transfer became the obsession of the 1970's and Tarkowski pursued the problem in Oxford (U.K.), in France, and with his group in Warsaw (Poland). A variant of this theme emerged during the 1980's and this was attempts to produce interspecies hybrids in Oxford and Warsaw. During the 1990's, the Warsaw laboratory became sufficiently well funded to make his trips unnecessary and his pupils became a Polish Diaspora of Embryologists.

  4. Effects triggered by platinum nanoparticles on primary keratinocytes

    OpenAIRE

    Konieczny P.; Goralczyk AG; Szmyd R; Skalniak L; Koziel J; Filon FL; Crosera M; Cierniak A; Zuba-Surma EK; Borowczyk J; Laczna E; Drukala J; Pyza E; Semik D; Woznicka O

    2013-01-01

    Piotr Konieczny,1,* Anna Grazyna Goralczyk,1,* Radoslaw Szmyd,1,* Lukasz Skalniak,1,* Joanna Koziel,2 Francesca Larese Filon,3 Matteo Crosera,4 Agnieszka Cierniak,1 Ewa K Zuba-Surma,5 Julia Borowczyk,5 Eliza Laczna,5 Justyna Drukala,5 Elzbieta Pyza,6 Danuta Semik,6 Olga Woznicka,6 Andrzej Klein,1 Jolanta Jura11Department of General Biochemistry, 2Department of Microbiology, Jagiellonian University, Kraków, Poland; 3Department of Public Health Sciences, 4Department of Chemical and P...

  5. The annoying creak of the hermeneutic circle – comments on Andrzej Szahaj’s article

    Directory of Open Access Journals (Sweden)

    Danuta Szajnert

    2013-01-01

    Full Text Available This essay is merely an additional commentary on the article entitled “Hirsch o interpretacji. Analiza krytyczna” (“Hirsch on interpretation. A critical analysis”. I do not focus here on Szahaj’s detailed objections to the concepts proposed by the author of Validity in Interpretation. I concentrate instead on the idea that forms the basis for such objections, i.e. radical, cultural interpretative constructivism. As a skeptical intentionalist, I cannot fully share his opinion and, therefore, I draw attention to views according to which the constructivist paradigm is becoming conventionalized and exhausted (especially in the humanities and to the possible ways in which it can be overcome.

  6. Sample Language of Modified Contract Elements from Existing CBAs, MOUs, or EWAs to Support Turnaround

    Science.gov (United States)

    Mass Insight Education (NJ1), 2011

    2011-01-01

    Organized by the key conditions areas for turnaround, "People, Program, Time and Money," this tool offers sample language for each contract element to serve as a model for modifications from a traditional CBA that may support a district's turnaround efforts. Sample language is offered from existing provisions in district-wide collective bargaining…

  7. Postsotsialistlik Eesti filmikunst kui rahvusülene kino / Ewa Mazierska

    Index Scriptorium Estoniae

    Mazierska, Ewa

    2011-01-01

    Käsitletakse Nõukogude Liidu lagunemise järel valminud Eesti filme, võrreldes neid mujal ja teisel ajal loodud linateostega. Võrdluse tulemusena selgub, et Eesti film on pidevas dialoogis Euroopa ja maailma kinoga, ent suudab rääkida ka oma häälega, et ta on nii rahvuslik kui ka rahvusülene nähtus, suutes ka ise midagi teistele pakkuda

  8. ESI-HI65 Ewa, Island of Oahu, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  9. Postsotsialistlik Eesti filmikunst kui rahvusülene kino / Ewa Mazierska

    Index Scriptorium Estoniae

    Mazierska, Ewa

    2011-01-01

    Käsitletakse Nõukogude Liidu lagunemise järel valminud Eesti filme, võrreldes neid mujal ja teisel ajal loodud linateostega. Võrdluse tulemusena selgub, et Eesti film on pidevas dialoogis Euroopa ja maailma kinoga, ent suudab rääkida ka oma häälega, et ta on nii rahvuslik kui ka rahvusülene nähtus, suutes ka ise midagi teistele pakkuda

  10. ESI-HI65 Ewa, Island of Oahu, Hawaii 2001 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  11. New Nordic Exceptionalism: Jeuno JE Kim and Ewa Einhorn’s 'The United Nations of Norden' and Other Realist Utopias

    DEFF Research Database (Denmark)

    Danbolt, Mathias

    2016-01-01

    that have been central to the debates on the branding of Nordicity over the last decades: on the one hand, the discourse of “Nordic exceptionalism,” that since the 1960s has been central to the promotion of a Nordic political, socio-economic, and internationalist “third way” model, and, on the other hand......, the discourse on the “New Nordic,” that emerged out of the New Nordic Food-movement in the early 2000s, and which has given art and culture a privileged role in the international re-fashioning of the Nordic brand. Through an analysis of Kim and Einhorn’s United Nations of Norden (UNN)-performance, the article...

  12. Polish Economy:Great Potential for Business Cooperation with China——Interview with Andrzej Kaczmarek,Polish Economics Ministry Vice Minister

    Institute of Scientific and Technical Information of China (English)

    Liu Jinliang; Sun Yongjian

    2006-01-01

    @@ Poland imports many products from China,but exports very little to China,which I think maybe could be increased on the Polish side.What we see now is large Korean investment,and then some Chinese and Japanese investment as well,so we need to increase the trade development with China,that's the mission of this trip.

  13. Ewa Bogalska-Martin (dir.), Être Noir Au Brésil Aujourd'hui. Identités et mémoires en mutation

    OpenAIRE

    Magdy, Mayada

    2015-01-01

    « Quand Ti-maître eut la certitude que le Noir pourrait apprendre, il cessa le jeu. Oui, le Noir apprenait ! », L’Histoire de Ponciá, Conceição Evaristo. En 2003, l’écrivaine brésilienne - Conceição Evaristo - a publié son roman qui porte sur le parcours de vie d’une petite-fille d’esclaves. Traduit en plusieurs langues, ce roman fait partie des œuvres stimulantes dans la littérature afrodescendante au Brésil. Dans le champ académique, plusieurs chercheurs abordent la question raciale, et sur...

  14. The gesture of post-mortem writing and other poetic gestures

    Directory of Open Access Journals (Sweden)

    Katarzyna Kuczyńska-Koschany

    2010-01-01

    Full Text Available The essay undertakes to investigate the phenomenon of erotic friendship as an “intertextual friendship” and, at the same time, “somatic (mis understanding” (German: Un-beziehung. The following considerations include a discussion on the relationship between Paul Verlaine and Arthur Rimbaud, viewed first of all as bohemian characters of bohemian life and the protagonists of the mitologised homo-erotic relationship. Beside a hermeneutic attempt at describing the intimacy shared by both poets, or stages in the development of their intimate relations (with reference to French literature of the subject and texts that have not yet been translated into Polish, the author writes extensively on the reception of the relationship of the legendary pair of friends-lovers A-war period, Agnieszka Holland’s film Total eclipse and the most recent poetical texts by Ewa Sonnenberg. The essay is complemented by some considerations on similar cases, analogous to the instance of the relationship between the two French poets: epistolary romance between R.M. Rilke and M. Tsvetaeva and, important within the context of the reception of Rimbaud in Poland — love/friendship exhibited in the letters between Andrzej Czajkowski and Anita Janowska.

  15. Archaeological and Paleontological Investigation at Kalaeloa (Barber’s Point), Honouliuli, ’EWA, O’Ahu Island, Federal Study Areas 1a and 1b, and State of Hawaii Optional Area 1,

    Science.gov (United States)

    1981-07-01

    DIAMOND HEAD 8 - EUCALYPTUS FOREST TRAINING AREA 30-FT DE RUSSY 9 -KAWAILOA TRAINING AREA 31-FT ARMSTRONG I0-KAHUKU TRAINING CAMP AND AREA 32-SAND ISLAND...evidence. In essence , paleo-malacological analysis is based upon the assumption that the specific composition of a fossil landsnail assemblage should

  16. Cooperative Recovery Initiative 2016: Preventing the Extinction of the Endangered Plants of the Ewa Plains through Restoration and Reintroduction at the Kalaeloa Unit of the Pearl Harbor National Wildlife Refuge, Hawaii

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Initial restoration efforts and control of the dominant alien plant species have been successful, but dedicated funds are needed to expeditiously complete removal of...

  17. Ewa Głażewska, Urszula Kusio, Komunikacja niewerbalna. Płeć i kultura. Wybrane zagadnienia, Lublin, Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej, 2012, 255 s., ISBN 978-83-7784-177-8

    Directory of Open Access Journals (Sweden)

    Paulina Banaśkiewicz

    2014-07-01

    Full Text Available Autorka recenzji opisuje pokrótce zawartość dwóch części książki na temat komunikacji niewerbalnej celem skupienia się na trzech walorach publikacji: konstrukcji książki, prezentacji niezbyt dobrze znanych w Polsce koncepcji wybitnych antropologów i socjologów oraz liczebności eksplikacji, które służą zilustrowaniu rozważań teoretycznych.English abstractThe author briefly describes the contents of the two parts of the book about non-verbal communication to focus on three qualities: design of the book, not very well known in Poland concepts of eminent anthropologists and sociologists and the number of explications, which illustrate the theoretical considerations. 

  18. Therapy of psoriasis with narrowband ultraviolet-B light influences plasma concentrations of MMP-2 and TIMP-2 in patients

    Directory of Open Access Journals (Sweden)

    Głażewska EK

    2016-10-01

    Full Text Available Edyta Katarzyna Głażewska,1 Marek Niczyporuk,1 Sławomir Ławicki,2 Maciej Szmitkowski,2 Monika Zajkowska,2 Grażyna Ewa Będkowska,3 Andrzej Przylipiak1 1Department of Esthetic Medicine, 2Department of Biochemical Diagnostics, 3Department of Haematological Diagnostics, Medical University, Białystok, Poland Background: Matrix metalloproteinases (MMPs, which show a significant ability to cleave the components of extracellular matrix, and tissue inhibitors of metalloproteinases (TIMPs, which slow down the activity of those enzymes, may be implicated in the pathogenesis and spread of psoriatic disease. This study aims to analyze plasma levels of MMP-2 and TIMP-2 in plaque psoriasis patients before and after the course of narrowband ultraviolet-B (NBUVB therapy with respect to disease advancement. Patients and methods: A total of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were enrolled into the study. Plasma levels of MMP-2 and TIMP-2 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index (PASI was used to define the disease advancement. Results: The results showed increased plasma levels of MMP-2 and TIMP-2, but this change was significant only in case of MMP-2 in total psoriatic group compared to healthy subjects. Moreover, there was an increase in the concentrations of chosen factors with an increase in the severity of the disease. The NBUVB therapy causes a decline in the concentration of the analyzed enzyme and its inhibitor, although this change was statistically significant in the total psoriatic group only in case of MMP-2. There was also a positive correlation between MMP-2, TIMP-2, and PASI score value. Conclusion: Our study highlights a possible important role of MMP-2 in the activity of psoriasis and clearance of disease symptoms. Moreover, plasma MMP-2 seems to be a valuable psoriasis biomarker. Keywords: gelatinase A, matrix metalloproteinases, tissue inhibitor of

  19. Probabilistic stability and "tall" wind profiles: theory and method for use in wind resource assessment

    DEFF Research Database (Denmark)

    Kelly, Mark C.; Troen, Ib

    2016-01-01

    the European Wind Atlas (EWA) methodology for site-to-site application. Theoretical and practical implications of the EWA methodology are also derived and described, including unprecedented documentation of the theoretical framework encompassing vertical extrapolation, as well as some improvement...

  20. The hybrid of SnO2 nanoparticle and polypyrrole aerogel: an excellent electromagnetic wave absorbing materials

    Science.gov (United States)

    Wang, Yu; Dai, Xiaoqing; Jiang, Wanchun; Wu, Fan; Xie, Aming

    2016-07-01

    As a kind of costless and lightweight material, SnO2 nanoparticles@polypyrrole hybrid aerogels have been synthesized and displayed electromagnetic wave absorbing (EWA) performance. Only with 10 wt% of nano-SnO2 filler loading in wax, effective EWA bandwidth of the hybrid aerogel can reach 7.28 GHz which is the widest lightweight EWA material among the reported absorbents. Through the regulation of sample thicknesses, effective EWA at lower frequencies can also be achieved. It was demonstrated that this aerogel can be used as an effective lightweight broadband EWA material.

  1. Effect of heparan sulfate and gold nanoparticles on muscle development during embryogenesis

    Directory of Open Access Journals (Sweden)

    Zielinska M

    2011-12-01

    Full Text Available Marlena Zielinska1,2, Ewa Sawosz1, Marta Grodzik1, Mateusz Wierzbicki1, Maria Gromadka1, Anna Hotowy3, Filip Sawosz3, Andrzej Lozicki1, Andrè Chwalibog31Division of Biotechnology and Biochemistry of Nutrition, Warsaw University of Life sciences, Warsaw, 2The Kielanowski Institute of Animal Physiology and Nutrition, Jablonna, Poland; 3Department of Basic Animal and Veterinary sciences, University of copenhagen, Frederiksberg, DenmarkPurpose: It was hypothesized that heparan sulfate (HS as an essential compound for myogenesis and nanoparticles of gold (nano-Au as highly reactive compounds can affect muscle development as a consequence of molecular regulation of muscle cell formation, and that these effects may be enhanced by a complex of HS conjugated with nano-Au. The objective of the present study was to determine the effect of administration of nano-Au, HS, and a nano-Au+HS complex on the morphological and molecular characteristics of breast muscle during embryogenesis.Methods: Chicken embryos were used as in vivo model. Fertilized chicken eggs (n = 350 were randomly divided into the control group and the groups treated with nano-Au, HS, and nano-Au+HS. The experimental solutions were given in ovo on the first day of incubation and the embryos were evaluated on day 20 of incubation. The methods included biochemical indi- ces in blood, immunohistochemistry, microscopy (transmission electron microscopy, scanning electron microscopy, confocal, and gene expression at the messenger ribonucleic acid and protein levels.Results: The treatments did not adversely affect mortality, organ weight, and homeostasis of the embryos. HS stimulated the development and maturation of breast muscle by increasing the number of nuclei, satellite cells, and muscle fibers and affected the expression of basic fibroblast growth factor-2 and paired-box transcription factor-7. Furthermore, the nano-Au+HS complex contributed to the increased number of myocytes and nuclei in

  2. Poola Nike 2008 / Hendrik Lindepuu

    Index Scriptorium Estoniae

    Lindepuu, Hendrik

    2008-01-01

    Poola mainekaima kirjandusauhinna Nike pälvis tänavu Olga Tokarczuki romaan "Jooksjad". Nominendid olid veel: Bronislaw Swiderski "Surma assistent", Krzysztof Varga "Hauakivi terrasiidiga", Andrzej Sosnowski "Pärast vikerkaart", Andrzej Szczeklik "Kore. Haigetest, haigusest ja hinge otsinguist", Wlodzimierz Nowaki "Pea ümbermõõt" ja Malgorzata Szejnerti "Must aed"

  3. Poola Nike 2008 / Hendrik Lindepuu

    Index Scriptorium Estoniae

    Lindepuu, Hendrik

    2008-01-01

    Poola mainekaima kirjandusauhinna Nike pälvis tänavu Olga Tokarczuki romaan "Jooksjad". Nominendid olid veel: Bronislaw Swiderski "Surma assistent", Krzysztof Varga "Hauakivi terrasiidiga", Andrzej Sosnowski "Pärast vikerkaart", Andrzej Szczeklik "Kore. Haigetest, haigusest ja hinge otsinguist", Wlodzimierz Nowaki "Pea ümbermõõt" ja Malgorzata Szejnerti "Must aed"

  4. Film, mis mõjub / Anne Applebaum ; tõlk. Kaarel Tarand

    Index Scriptorium Estoniae

    Applebaum, Anne

    2008-01-01

    Ajalehes The New York Review of Books (14. II) ilmunud artikkel poola režissööri Andrzej Wajda filmist "Katõn", mis räägib Katõni massimõrvast. Andrzej Wajda pälvis sel aastal Eesti presidendilt Maarjamaa Risti III klassi teenetemärgi

  5. Poolakad näitavad etlemiskunsti / Gert Hatsukov ; interv. Johannes Saar

    Index Scriptorium Estoniae

    Hatsukov, Gert

    2004-01-01

    Ürituse korraldaja Gert Hatsukoviga poola etlemiskunstnikest Pawel Kwasniewskist, Wladislav Kazmierczakist, Ewa Rybskast, Artur Grabowskist ja Dariusz Fodczukist. Poola etlemiskunsti õhtupoolik "Transmission" toimub Vaal-galeriis

  6. Poolakad näitavad etlemiskunsti / Gert Hatsukov ; interv. Johannes Saar

    Index Scriptorium Estoniae

    Hatsukov, Gert

    2004-01-01

    Ürituse korraldaja Gert Hatsukoviga poola etlemiskunstnikest Pawel Kwasniewskist, Wladislav Kazmierczakist, Ewa Rybskast, Artur Grabowskist ja Dariusz Fodczukist. Poola etlemiskunsti õhtupoolik "Transmission" toimub Vaal-galeriis

  7. eFORGE : A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data

    NARCIS (Netherlands)

    Breeze, Charles E.; Paul, Dirk S.; van Dongen, Jenny; Butcher, Lee M.; Ambrose, John C.; Barrett, James E.; Lowe, Robert; Rakyan, Vardhman K.; Iotchkova, Valentina; Frontini, Mattia; Downes, Kate; Ouwehand, Willem H.; Laperle, Jonathan; Jacques, Pierre-ETienne; Bourque, Guillaume; Bergmann, Anke K.; Siebert, Reiner; Vellenga, Edo; Saeed, Sadia; Matarese, Filomena; Martens, Joost H. A.; Stunnenberg, Hendrik G.; Teschendorff, Andrew E.; Herrero, Javier; Birney, Ewan; Dunham, Ian; Beck, Stephan

    2016-01-01

    Epigenome-wide association studies (EWAS) provide an alternative approach for studying human disease through consideration of non-genetic variants such as altered DNA methylation. To advance the complex interpretation of EWAS, we developed eFORGE (http://eforge.cs.ucl.ac.uk/), a new stand-alone and

  8. Sündmused leiavad aset ikka inimese peas, mitte rahakotis / Tiit Palu ; interv. Margot Visnap

    Index Scriptorium Estoniae

    Palu, Tiit, 1970-

    2008-01-01

    Endla teatri eesseisvast hooajast, teatri majanduslikust olukorrast. Riias Balti teatrifestivalil etendunud Kalju Komissarovi lavastusest "Kangelane", 4. oktoobril esietenduvast Andrzej Saramonowiczi komöödiast "Testosteroon" ja teistest uuslavastustest lühidalt

  9. Teatrisügise macho-pähklid / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2008-01-01

    Andrzej Saramonowiczi näidend "Testosteroon" Endla teatris, lavastaja Enn Keerd. Ott Aardami noortetükist "Poks", lavastaja autor Ugala teatris. Kristjan Sarve debüütlavastus "Rambo" David Morrelli romaani "Esimene veri" ainetel NO99 teatris

  10. VIP EE, Ms Ene Ergma, President of the Estonia Parliament (Riigikogu), Republic of Estonia (attending the 3rd World Conference of Speakers of Parliament in Geneva)

    CERN Multimedia

    2010-01-01

    She toured the LHC superconducting magnet test hall with Andrzej Siemko, leader of the machine protection and electrical integrity group in the technology department, and also saw the CERN Control Centre, the CMS experiment and the LHC tunnel.

  11. [Umgesiedelt - Vertrieben. Deutschbalten und Polen 1939-1945 im Warthegau] / Karsten Brüggemann

    Index Scriptorium Estoniae

    Brüggemann, Karsten, 1965-

    2012-01-01

    Arvustus: Umgesiedelt - Vertrieben. Deutschbalten und Polen 1939-1945 im Warthegau / hrsg. von Eckhart Neander und Andrzej Sakson. Marburg : Verlag Herder-Institut 2010. (Tagungen zur Ostmitteleuropa-Forschung, 29)

  12. Euroopa ajalugu uutes filmides / Riho Laurisaat

    Index Scriptorium Estoniae

    Laurisaar, Riho

    2008-01-01

    Euroopa ajaloost uuemates ajalooainelistes mängufilmides - Poola "Katõn" (Andrzej Wajda), Soome "Piir 1918" (Lauri Törhönen), Läti "Riia kaitsjad" (Aigars Grauba), Eesti "Nimed marmortahvlil" (Elmo Nüganen)

  13. The New World Order: A Second Look. A Selected Bibliography.

    Science.gov (United States)

    1994-08-01

    228pp. (P95.8 .054 1993) Podraza, Andrzej. The Western European Union and Central Europe: A New Relationship. London: Royal Institute of International...Press, 1993. 461pp. (HF1413 .C73 1993) Jackbon, Tim. The Next Battleagound: Lanan. America. and the New Europea Market. Boston: Houghton Mufflin, 1993...War College, 6 April 1993. 47 pp. (AD-A265-096) 35 Podraza, Andrzej. The Western Euroocan Union and Central Europe: A New Relationship. London: Royal

  14. The doripenem serum concentrations in intensive care patients suffering from acute kidney injury, sepsis, and multi organ dysfunction syndrome undergoing continuous renal replacement therapy slow low-efficiency dialysis

    OpenAIRE

    Wieczorek A; Tokarz A; Gaszynski W; Gaszynski T

    2014-01-01

    Andrzej Wieczorek, Andrzej Tokarz, Wojciech Gaszynski, Tomasz Gaszynski Department of Anesthesiology and Intensive Therapy, Medical University of Lodz, Lodz, Poland Abstract: Doripenem is a novel wide-spectrum antibiotic, and a derivate of carbapenems. It is an ideal antibiotic for treatment of serious nosocomial infections and severe sepsis for its exceptionally high efficiency and broad antibacterial spectrum of action. Doripenem is eliminated mainly by the kidneys. In cases of acute kidn...

  15. JPRS Report, East Europe.

    Science.gov (United States)

    2007-11-02

    Across Polish-Soviet Border [Andrzej Malinowski Interview; GAZETA POZNANSKA, 16 Sep 87] 35 Szalaida on Polish-Soviet Electronics Cooperation [Zbigniew...Across Polish-Soviet Border 26000029b Poznan GAZETA POZNANSKA in Polish 16Sep87p4 [Interview with Andrzej Malinowski , Deputy Minister of Domestic...countries, are arousing interest. I asked the Deputy Minister of Domestic Trade and Services, Andr- zej Malinowski , to talk to us on this subject

  16. Effects triggered by platinum nanoparticles on primary keratinocytes

    Directory of Open Access Journals (Sweden)

    Konieczny P

    2013-10-01

    Full Text Available Piotr Konieczny,1,* Anna Grazyna Goralczyk,1,* Radoslaw Szmyd,1,* Lukasz Skalniak,1,* Joanna Koziel,2 Francesca Larese Filon,3 Matteo Crosera,4 Agnieszka Cierniak,1 Ewa K Zuba-Surma,5 Julia Borowczyk,5 Eliza Laczna,5 Justyna Drukala,5 Elzbieta Pyza,6 Danuta Semik,6 Olga Woznicka,6 Andrzej Klein,1 Jolanta Jura11Department of General Biochemistry, 2Department of Microbiology, Jagiellonian University, Kraków, Poland; 3Department of Public Health Sciences, 4Department of Chemical and Pharmaceutical Sciences, University of Trieste, Trieste, Italy; 5Department of Cell Biology, 6Department of Cell Biology and Imaging, Jagiellonian University, Kraków, Poland*These authors equally contributed to this workAbstract: The platinum (Pt-group elements (PGEs represent a new kind of environmental pollutant and a new hazard for human health. Since their introduction as vehicle-exhaust catalysts, their emissions into the environment have grown considerably compared with their low natural concentration in the earth crust. PGE emissions from vehicle catalysts can be also in the form of nanometer-sized particles (Pt nanoparticles [PtNPs]. These elements, both in their metallic form or as ions solubilized in biological media, are now recognized as potent allergens and sensitizers. Human skin is always exposed to toxic particles; therefore, in the present study we addressed the question of whether polyvinylpyrrolidone-coated PtNPs may have any negative effects on skin cells, including predominantly epidermal keratinocytes. In this study, PtNPs of two sizes were used: 5.8 nm and 57 nm, in concentrations of 6.25, 12.5, and 25 µg/mL. Both types of NPs were protected with polyvinylpyrrolidone. Primary keratinocytes were treated for 24 and 48 hours, then cytotoxicity, genotoxicity, morphology, metabolic activity, and changes in the activation of signaling pathways were investigated in PtNP-treated cells. We found that PtNPs trigger toxic effects on primary keratinocytes

  17. Barbers Point Sewage Outfall Fish Census from Annual Surveys 1991-2010 (NODC Accession 0073346)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Honouliuli Wastewater Treatment Plant (WWTP) located in Ewa, Oahu, Hawaii, near Barbers Point (Kalaeloa) has been in operation since 1982. It releases...

  18. Homme kell 14 algab Vaala galeriis järjekordse "INPORTi" raames...

    Index Scriptorium Estoniae

    2004-01-01

    Poola kunstnike Dariusz Fodczuki (sünd. 1966), Wladislaw Kazmierczaki (sünd. 1951), Ewa Rybska (sünd. 1958), Artur Grabowski ja Pawel Kwasniewski (sünd. 1963) performance'ite esitlus. Korraldaja Gert Hatsukov

  19. 77 FR 67055 - Application for a Presidential Permit To Operate and Maintain Pipeline Facilities (Line 39) on...

    Science.gov (United States)

    2012-11-08

    ... Dhabi, United Arab Emirates. Line 39 was initially constructed and owned by Polysar Hydrocarbons Inc... Diplomacy, Energy Resources Bureau (ENR/EDP/EWA), Department of State, 2201 C St. NW., Ste 4843,...

  20. Homme kell 14 algab Vaala galeriis järjekordse "INPORTi" raames...

    Index Scriptorium Estoniae

    2004-01-01

    Poola kunstnike Dariusz Fodczuki (sünd. 1966), Wladislaw Kazmierczaki (sünd. 1951), Ewa Rybska (sünd. 1958), Artur Grabowski ja Pawel Kwasniewski (sünd. 1963) performance'ite esitlus. Korraldaja Gert Hatsukov

  1. Sharing Water with Nature: Insights on Environmental Water Allocation from a Case Study of the Murrumbidgee Catchment, Australia

    Directory of Open Access Journals (Sweden)

    Becky Swainson

    2011-02-01

    Full Text Available Human use of freshwater resources has placed enormous stress on aquatic ecosystems in many regions of the world. At one time, this was considered an acceptable price to pay for economic growth and development. Nowadays, however, many societies are seeking a better balance between healthy aquatic ecosystems and viable economies. Unfortunately, historically, water allocation systems have privileged human uses over the environment. Thus, jurisdictions seeking to ensure that adequate water is available for the environment must typically deal with the fact that economies and communities have become dependent on water. Additionally, they must often layer institutions for environmental water allocation (EWA on top of already complex institutional systems. This paper explores EWA in a jurisdiction – New South Wales (NSW, Australia – where water scarcity has become a priority. Using an in-depth case study of EWA in the Murrumbidgee catchment, NSW, we characterise the NSW approach to EWA with the goal of highlighting the myriad challenges encountered in EWA planning and implementation. Sharing water between people and the environment, we conclude, is much more than just a scientific and technical challenge. EWA in water-scarce regions involves reshaping regional economies and societies. Thus, political and socio-economic considerations must be identified and accounted for from the outset of planning and decision-making processes.

  2. Evaluation of three adolescent sexual health programs in ha noi and khanh hoa province, Vietnam.

    Science.gov (United States)

    Pham, Van; Nguyen, Hoang; Tho, Le Huu; Minh, Truong Tan; Lerdboon, Porntip; Riel, Rosemary; Green, Mackenzie S; Kaljee, Linda M

    2012-01-01

    With an increase in sexual activity among young adults in Vietnam and associated risks, there is a need for evidence-based sexual health interventions. This evaluation of three sexual health programs based on the Protection Motivation Theory (PMT) was conducted in 12 communes in Ha Noi, Nha Trang City, and Ninh Hoa District. Inclusion criteria included unmarried youth 15-20 years residing in selected communes. Communes were randomly allocated to an intervention, and participants were randomly selected within each commune. The intervention programs included Vietnamese Focus on Kids (VFOK), the gender-based program Exploring the World of Adolescents (EWA), and EWA plus parental and health provider education (EWA+). Programs were delivered over a ten-week period in the communities by locally trained facilitators. The gender-based EWA program with parental involvement (EWA+) compared to VFOK showed significantly greater increase in knowledge. EWA+ in comparison to VFOK also showed significant decrease at immediate postintervention for intention to have sex. Sustained changes are observed in all three interventions for self-efficacy condom use, self-efficacy abstinence, response efficacy for condoms, extrinsic rewards, and perceived vulnerability for HIV. These findings suggest that theory-based community programs contribute to sustained changes in knowledge and attitudes regarding sexual risk among Vietnamese adolescents.

  3. Evaluation of Three Adolescent Sexual Health Programs in Ha Noi and Khanh Hoa Province, Vietnam

    Directory of Open Access Journals (Sweden)

    Van Pham

    2012-01-01

    Full Text Available With an increase in sexual activity among young adults in Vietnam and associated risks, there is a need for evidence-based sexual health interventions. This evaluation of three sexual health programs based on the Protection Motivation Theory (PMT was conducted in 12 communes in Ha Noi, Nha Trang City, and Ninh Hoa District. Inclusion criteria included unmarried youth 15–20 years residing in selected communes. Communes were randomly allocated to an intervention, and participants were randomly selected within each commune. The intervention programs included Vietnamese Focus on Kids (VFOK, the gender-based program Exploring the World of Adolescents (EWA, and EWA plus parental and health provider education (EWA+. Programs were delivered over a ten-week period in the communities by locally trained facilitators. The gender-based EWA program with parental involvement (EWA+ compared to VFOK showed significantly greater increase in knowledge. EWA+ in comparison to VFOK also showed significant decrease at immediate postintervention for intention to have sex. Sustained changes are observed in all three interventions for self-efficacy condom use, self-efficacy abstinence, response efficacy for condoms, extrinsic rewards, and perceived vulnerability for HIV. These findings suggest that theory-based community programs contribute to sustained changes in knowledge and attitudes regarding sexual risk among Vietnamese adolescents.

  4. Managing water to protect fish: A review of California's environmental water account, 2001-2005

    Science.gov (United States)

    Brown, L.R.; Kimmerer, W.; Brown, R.

    2009-01-01

    The Sacramento-San Joaquin Delta, the landward reach of the San Francisco Estuary, provides habitat for threatened delta smelt, endangered winter-run Chinook salmon, and other species of concern. It is also the location of huge freshwater diversion facilities that entrain large numbers of fish. Reducing the entrainment of listed fishes into these facilities has required curtailment of pumping, reducing the reliability of water deliveries. We reviewed the first 5 years (2001-2005) of the Environmental Water Account (EWA), a program instituted to resolve conflicts between protecting listed fishes and providing a reliable water supply. The EWA provided fishery agencies with control over 0.2-0.4 km3 of water to be used for fish protection at no cost to users of exported water, and fish agencies guaranteed no disruption of water supply for fish protection. The EWA was successful in reducing uncertainty in water supply; however, its contribution to the recovery of listed fishes was unclear. We estimated the effectiveness of the EWA to be modest, increasing the survival of winter-run Chinook salmon by 0-6% (dependent on prescreen mortality), adult delta smelt by 0-1%, and juvenile delta smelt by 2-4%. Allocating EWA water for a single life stage of one species could provide larger gains in survival. An optimally allocated EWA of equal size to the median of the first 5 years could increase abundance of juvenile delta smelt up to 7% in the springs of dry years. If the EWA is to become a long-term program, estimates of efficacy should be refined. If the program is to be held accountable for quantitative increases in fish populations, it will be necessary to integrate scientific, possibly experimental, approaches. ?? 2008 Springer Science+Business Media, LLC.

  5. An epigenome-wide DNA methylation study of PTSD and depression in World Trade Center responders.

    Science.gov (United States)

    Kuan, P-F; Waszczuk, M A; Kotov, R; Marsit, C J; Guffanti, G; Gonzalez, A; Yang, X; Koenen, K; Bromet, E; Luft, B J

    2017-06-27

    Previous epigenome-wide association studies (EWAS) of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) have been inconsistent. This may be due to small sample sizes, and measurement and tissue differences. The current two EWA analyses of 473 World Trade Center responders are the largest to date for both PTSD and MDD. These analyses investigated DNA methylation patterns and biological pathways influenced by differentially methylated genes associated with each disorder. Methylation was profiled on blood samples using Illumina 450 K Beadchip. Two EWA analyses compared current versus never PTSD, and current versus never MDD, adjusting for cell types and demographic confounders. Pathway and gene set enrichment analyses were performed to understand the complex biological systems of PTSD and MDD. No significant epigenome-wide associations were found for PTSD or MDD at an FDR P<0.05. The majority of genes with differential methylation at a suggestive threshold did not overlap between the two disorders. Pathways significant in PTSD included a regulator of synaptic plasticity, oxytocin signaling, cholinergic synapse and inflammatory disease pathways, while only phosphatidylinositol signaling and cell cycle pathways emerged in MDD. The failure of the current EWA analyses to detect significant epigenome-wide associations is in contrast with disparate findings from previous, smaller EWA and candidate gene studies of PTSD and MDD. Enriched gene sets involved in several biological pathways, including stress response, inflammation and physical health, were identified in PTSD, supporting the view that multiple genes play a role in this complex disorder.

  6. "Baltiiski dom 2008" : uvelitshitelnoje steklo / Eteri Kekelidze

    Index Scriptorium Estoniae

    Kekelidze, Eteri, 1944-

    2008-01-01

    Peterburis toimunud kaheksteistkümnenda rahvusvahelise teatrifestivali "Baltiiski dom" lavastustest - Kristian Smedsi "Tundmatu sõdur", Alvis Hermanise "Läti rong", Luk Percevali "Kaubareisija surm", Igor Konjajevi "Matke mind põrandaliistu taha" ja Andrzej Bubeni "Vene moos". Ka teater NO99 osalemisest Tiit Ojasoo lavastusega "GEP"

  7. Põnevust, kurbust ja elegantsi / Kristiina Davidjants, Kaarel Kressa

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2008-01-01

    !". PÖFFi filme - Taani mängufilm "Hiirmõnnelik" ("Frygtelig lykkelig"), režissöör Henrik Ruben Genz, Poola mängufilm "Katõn" ("Katyn"), režissöör Andrzej Wajda ja Prantsusmaa mängufilm "Suvetunnid" ("L'heure d'ete"), režissöör Olivier Assayas

  8. Post mortem : Katõn ja meie enda tõrjutud mälestused / Rauno Thomas Moss

    Index Scriptorium Estoniae

    Moss, Rauno Thomas

    2008-01-01

    Poola filmilavastaja Andrzej Wajda mängufilmist "Katõn" (Poola, 2007) ja Imbi Paju dokumentaalfilmist "Tõrjutud mälestused" (Eesti - Soome, 2005). Artikli lõpus mõlema filmi režissööridest ja A. Wajda filmograafia

  9. The Carpathians: Integrating Nature and Society Towards Sustainability

    Directory of Open Access Journals (Sweden)

    Martin F. Price

    2015-08-01

    Full Text Available Reviewed: The Carpathians: Integrating Nature and Society Towards Sustainability. Edited by Jacek Kozak, Katarzyna Ostapowicz, Andrzej Bytnerowicz, and Bartłomiej Wyżga. Heidelberg, Germany: Springer, 2013. vi + 717 pp. US $ 129.00, € 103.99. Also available as an e-book. ISBN 978-3-642-12724-3.

  10. Kirjad Sirbile / Mart Kivastik

    Index Scriptorium Estoniae

    Kivastik, Mart, 1963-

    2007-01-01

    Mannheimi filmifestivalist. Filmidest "Nadine" (rezh. Erik de Bruyn), "Dead End", "Kremen" (rezh. Aleksei Mizgirev), "Overnight" (rezh. Ferenc Török), "Mirush" ("Blodsband", rezh. Marius Holst), "Sztuczki" (rezh. Andrzej Jakimowski), "Por sus propios ojos" ("Through her own eyes", rezh. Liliana Paolinelli), "Terra Sonambula" ("Sleepwalking Land", rezh. Teresa Prata). Festivali auhinnatud filmid

  11. Svoboda 'severnõh Afin' : derptskaja Polonia / Sergei Issakov, Pavel Sigalov

    Index Scriptorium Estoniae

    Issakov, Sergei, 1931-2013

    1997-01-01

    Korporatsioonist 'Polonia' (asut. 1828. a.) jt. poola üliõpilaste ühendustest Tartus. Tartu ülikoolis õppinud poola kirjanikest ja kirjandusteadlasest: Alfons Walicki, Aleksander Karol Groza, Edward Zheligowski, Bronislaw Zaleski, Jzef Bohdan Dzienkonski, Ludomir Gadon, Jzef Weyssenhoff, Marian Zdziechowski, Andrzej Niemojewski, Ludwik Bruner, Jerzy Jankowski

  12. Pärnu filmifestivali peaauhind läks Poola dokfilmile

    Index Scriptorium Estoniae

    2008-01-01

    Pärnu 22. dokumentaal- ja antropoloogiafilmide festivali lõputseremoonial 12. juulil jagati auhinnad. Festivali parima filmi auhinna, Lääne-Eesti käsitööteki võitsid Poola filmitegijad Andrzej Dybczak ja Jacek Naglowski filmiga "Gugara". Ka teistest auhinnasaajatest

  13. Seksiskandaal ähvardab Poolat uute valimistega / Krister Paris

    Index Scriptorium Estoniae

    Paris, Krister

    2006-01-01

    Poola ajalehes Gazeta Wyorcza süüdistati Enesekaitse Partei juhti Andrzej Lepperit, et ta on jaganud töökohti vastutasuks seksuaalteenuste eest, väidetavalt on juhtumiga seotud ka parlamendiliige Stanislaw Lyzwinski. Lisa: Poliitilised tõmblused

  14. Ilves annab Wajdale Maarjamaa Risti

    Index Scriptorium Estoniae

    2008-01-01

    President Toomas Hendrik Ilves annab Poola visiidi käigus üle Maarjamaa Risti III klassi teenetemärgi Poola režissöörile, tänavu parima võõrkeelse filmi Oscarile kandideerinud linateose "Katõn" autorile Andrzej Wajdale. Vabariigi President töövisiidil Poolas 1.-3.08.2008

  15. Eesti ja Poola president rääkisid kahe riigi koostööst

    Index Scriptorium Estoniae

    2008-01-01

    Vabariigi President töövisiidil Poolas 1.-3.08.2008. Eesti riigipea kohtus Poola presidendi Lech Kaczynskiga, andis Poola režissöörile Andrzej Wajdale üle Maarjamaa Risti teenetemärgi, asetas Varssavis lilled hiljuti hukkunud poliitiku Bronislaw Geremeki hauale

  16. Mälu, kallis vara / Peeter Maimik

    Index Scriptorium Estoniae

    Maimik, Peeter, 1944-2010

    2009-01-01

    Poola ohvitseride mõrvamisest NKVD poolt 1940. aastal Katõnis, Andrzej Wajda selleteemalisest filmist "Katõn" ja ajaloolise mälu säilitamise olulisusest. Inimsusevastaste kuritegude uurimise rahvusvahelise komisjoni uurimistööst, mis käsitleb Saksa ja Nõukogude okupatsioone Eestis

  17. Ильвес в Польше

    Index Scriptorium Estoniae

    2008-01-01

    President Toomas Hendrik Ilvese visiidist Poolasse 1.-3.08.2008. Eesti president kohtus Poola presidendi Lech Kaczynskiga ning andis Poola režissöörile Andrzej Wajdale üle Maarjamaa Risti teenetemärgi. Eesti ja Poola riigipead osalesid ka pärgade asetamise tseremoonial Varssavi sõjaväekalmistul

  18. Post mortem : Katõn ja meie enda tõrjutud mälestused / Rauno Thomas Moss

    Index Scriptorium Estoniae

    Moss, Rauno Thomas

    2008-01-01

    Poola filmilavastaja Andrzej Wajda mängufilmist "Katõn" (Poola, 2007) ja Imbi Paju dokumentaalfilmist "Tõrjutud mälestused" (Eesti - Soome, 2005). Artikli lõpus mõlema filmi režissööridest ja A. Wajda filmograafia

  19. President Ilvese töövisiit Poola Vabariiki

    Index Scriptorium Estoniae

    2008-01-01

    Vabariigi President töövisiidil Poolas 1.-3.08.2008. Eesti riigipea kohtus Poola presidendi Lech Kaczynskiga, andis Poola režissöörile Andrzej Wajdale üle Maarjamaa Risti teenetemärgi, osales pärgade asetamise tseremoonial Varssavi sõjaväekalmistul

  20. Kirjad Sirbile / Mart Kivastik

    Index Scriptorium Estoniae

    Kivastik, Mart, 1963-

    2007-01-01

    Mannheimi filmifestivalist. Filmidest "Nadine" (rezh. Erik de Bruyn), "Dead End", "Kremen" (rezh. Aleksei Mizgirev), "Overnight" (rezh. Ferenc Török), "Mirush" ("Blodsband", rezh. Marius Holst), "Sztuczki" (rezh. Andrzej Jakimowski), "Por sus propios ojos" ("Through her own eyes", rezh. Liliana Paolinelli), "Terra Sonambula" ("Sleepwalking Land", rezh. Teresa Prata). Festivali auhinnatud filmid

  1. Põnevust, kurbust ja elegantsi / Kristiina Davidjants, Kaarel Kressa

    Index Scriptorium Estoniae

    Davidjants, Kristiina, 1974-

    2008-01-01

    !". PÖFFi filme - Taani mängufilm "Hiirmõnnelik" ("Frygtelig lykkelig"), režissöör Henrik Ruben Genz, Poola mängufilm "Katõn" ("Katyn"), režissöör Andrzej Wajda ja Prantsusmaa mängufilm "Suvetunnid" ("L'heure d'ete"), režissöör Olivier Assayas

  2. Seksiskandaal ähvardab Poolat uute valimistega / Krister Paris

    Index Scriptorium Estoniae

    Paris, Krister

    2006-01-01

    Poola ajalehes Gazeta Wyorcza süüdistati Enesekaitse Partei juhti Andrzej Lepperit, et ta on jaganud töökohti vastutasuks seksuaalteenuste eest, väidetavalt on juhtumiga seotud ka parlamendiliige Stanislaw Lyzwinski. Lisa: Poliitilised tõmblused

  3. Svoboda 'severnõh Afin' : derptskaja Polonia / Sergei Issakov, Pavel Sigalov

    Index Scriptorium Estoniae

    Issakov, Sergei, 1931-2013

    1997-01-01

    Korporatsioonist 'Polonia' (asut. 1828. a.) jt. poola üliõpilaste ühendustest Tartus. Tartu ülikoolis õppinud poola kirjanikest ja kirjandusteadlasest: Alfons Walicki, Aleksander Karol Groza, Edward Zheligowski, Bronislaw Zaleski, Jzef Bohdan Dzienkonski, Ludomir Gadon, Jzef Weyssenhoff, Marian Zdziechowski, Andrzej Niemojewski, Ludwik Bruner, Jerzy Jankowski

  4. 77 FR 72431 - Application for a Presidential Permit To Operate and Maintain Pipeline Facilities on the Border...

    Science.gov (United States)

    2012-12-05

    ... FURTHER INFORMATION CONTACT: Office of Energy Diplomacy, Energy Resources Bureau (ENR/EDP/EWA) Department... ULC (Plains Midstream). Specifically, Plains Midstream acquired BP Canada Energy Corporation, which..., Western Hemisphere & Africa, Bureau of Energy Resources, U.S. Department of State. BILLING CODE 4710-09-P...

  5. Estructuración del trabajo: condiciones de trabajo

    OpenAIRE

    Pedroso Beneite, Clara

    2013-01-01

    Origen de las condiciones de trabajo y ergonomía, contenido de las condiciones de trabajo y sus métodos de evaluación. Especial análisis del método EWA en referencia a una oficina de usuario de PVD.

  6. Poolakad eesti kunsti omaruumis / Riin Kübarsepp

    Index Scriptorium Estoniae

    Kübarsepp, Riin, 1978-

    2004-01-01

    Vaal-galeriis 29. V toimunud poola tegevuskunsti pärastlõunast "Tramsmission" ja osalenud kunstnikest (Dariusz Fodczuki, Wladislaw Kazmierczak, Ewa Rybska, Pawel Kwasniewski). Tähenduslikuna mõjus galeriis väljas olnud Jüri Ojaveri ruumiinstallatsioon "...töökas ning leidlik"

  7. Poolakad eesti kunsti omaruumis / Riin Kübarsepp

    Index Scriptorium Estoniae

    Kübarsepp, Riin, 1978-

    2004-01-01

    Vaal-galeriis 29. V toimunud poola tegevuskunsti pärastlõunast "Tramsmission" ja osalenud kunstnikest (Dariusz Fodczuki, Wladislaw Kazmierczak, Ewa Rybska, Pawel Kwasniewski). Tähenduslikuna mõjus galeriis väljas olnud Jüri Ojaveri ruumiinstallatsioon "...töökas ning leidlik"

  8. Using Application-Domain Knowledge in the Runtime Support of Multi-Experiment Computational Studies

    Science.gov (United States)

    2009-01-01

    Ewa Deelman, Yolanda Gil, Carl Kesselman, Amit Agarwal, Gaurang Mehta, and Karan Vahi. The role of planning in grid computing. In Proceedings of the...Congress on Computational Intelligence, pages 82–87, 1994. [48] Ken Brodlie Jason Wood and Jeremy Walton. Gviz - visualization and steering for the grid

  9. Serwisy społecznościowe dla naukowców (SSN) na przykładzie ResearchGate i Academia.edu

    OpenAIRE

    Rozkosz, Ewa

    2014-01-01

    Artykuł ma na celu przedstawienie wybranych funkcji serwisów społecznościowych dla naukowców (SSN). Dokonano analizy dwóch najpopularniejszych serwisów: ResearchGate oraz Academia.edu. Ewa Rozkosz

  10. Design characteristics of Curved Blade Aerator w.r.t. aeration ...

    African Journals Online (AJOL)

    user

    energy requirements of a secondary waste-water treatment plan (Wasner et al, 1977). Dissolved oxygen ... aquaculture industry, however, are different than those of the waste-water treatment industry. ...... European Water Management Online, EWA 2002. ... Process design of aeration system for biological waste treatment.

  11. 77 FR 67056 - Application for a Presidential Permit To Operate and Maintain Pipeline Facilities on the Border...

    Science.gov (United States)

    2012-11-08

    ... subsidiary of the International Petroleum Investment Corporation (``IPIC'') which is wholly owned by the... Hemisphere and Africa (ENR/EDP/EWA), Department of State, Washington, DC 20520, Tel: 202-647-9158, EMAIL..., Western Hemisphere and Africa, Bureau of Energy Resources, U.S. Department of State. BILLING CODE...

  12. An Introduction to Parallelism, Concurrency and Acceleration (1/2)

    CERN Document Server

    CERN. Geneva

    2016-01-01

    Concurrency and parallelism are firm elements of any modern computing infrastructure, made even more prominent by the emergence of accelerators. These lectures offer an introduction to these important concepts. We will begin with a brief refresher of recent hardware offerings to modern-day programmers. We will then open the main discussion with an overview of the laws and practical aspects of scalability. Key parallelism data structures, patterns and algorithms will be shown. The main threats to scalability and mitigation strategies will be discussed in the context of real-life optimization problems. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and initiated projects with the private sector (e.g. HP and Google), as well as international research institutes, such as EPFL. Current...

  13. Supercomputing - Use Cases, Advances, The Future (2/2)

    CERN Document Server

    CERN. Geneva

    2017-01-01

    Supercomputing has become a staple of science and the poster child for aggressive developments in silicon technology, energy efficiency and programming. In this series we examine the key components of supercomputing setups and the various advances – recent and past – that made headlines and delivered bigger and bigger machines. We also take a closer look at the future prospects of supercomputing, and the extent of its overlap with high throughput computing, in the context of main use cases ranging from oil exploration to market simulation. On the second day, we will focus on software and software paradigms driving supercomputers, workloads that need supercomputing treatment, advances in technology and possible future developments. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and i...

  14. East Europe Report.

    Science.gov (United States)

    2007-11-02

    Polonia Firm Activity Cited (GLOD ROBOTNICZY, 9 Sep 86) 39 Fate of Kowalski Turbine Invention Followed, Questioned (Andrzej Krzysztof Wroblewski...EUIAKETIES’ IN LODZ AREA POLONIA FIRM ACT1VT1Y CITED Lodz GLOS ROBOTNICZY in Polish 9 Sep 86 p 6 [Text] There are 36 Polonia firms employee 3445 workers...food preservation and manufacturing farm machines and equipment. The Provincial Committee on Profiteering dealt with the operation of Polonia firms

  15. The Future of Transcaspian Security

    Science.gov (United States)

    2002-08-01

    international security and not only in the CIS. Dylan Hendrickson and Andrzej Karkoszka of SIPRI observe that, The international community is seeking to...Winter, 1999-2000, pp. 69-80; Anatol Lieven, “ Bobbing for Rotten Apples: Geopolitical Agendas in Ukraine and the Western CIS,” paper presented to the...Eavis and Kefford, pp. 3-14. 50. Dylan Hendrickson and Andrezj Karkoszka, “The Challenges of Security Sector Reform,” Relief Web: Highlights from

  16. VIP visit to CERN P5 CMS of Pakistan Science Members

    CERN Multimedia

    Hoch, Michael

    2012-01-01

    VIP visit to CERN P5 CMS of PAEC & JCPC Science Members List of PAEC Visitors: Dr. Badar Suleman - Member Science PAEC & Member of JCPC Dr. Waqar M. Butt - Member Engineering (Head of HMC3) Dr. Maqsood Ahmad - Chief Scientist (Head of Accelerator Project) List of CMS participants: Prof. Joseph Incandela, CMS Spokesperson Dr. Austin Ball, CMS Technical Coordinator Mr Andrzej Charkiewicz, CMS Resources Manager Dr. Michael Hoch, CMS Outreach activities, CMS photographer and guide Dr. Achille Petrilli, CMS Team Leader

  17. Nonlinear optimization

    CERN Document Server

    Ruszczynski, Andrzej

    2011-01-01

    Optimization is one of the most important areas of modern applied mathematics, with applications in fields from engineering and economics to finance, statistics, management science, and medicine. While many books have addressed its various aspects, Nonlinear Optimization is the first comprehensive treatment that will allow graduate students and researchers to understand its modern ideas, principles, and methods within a reasonable time, but without sacrificing mathematical precision. Andrzej Ruszczynski, a leading expert in the optimization of nonlinear stochastic systems, integrates t

  18. East Europe Report, Political, Sociological and Military Affairs, No. 2216.

    Science.gov (United States)

    2008-02-15

    every socialist country, with reference to the theoretical prin- ciples of our systems, also the millions of believing citizens have learned to demand...self- hypnosis his role as a shaman pro- phet, has passed the point where he can realistically perceive our increased -- fortunately increased--ability...the board. I believe that more people should participate in volunteer civic activities." Andrzej Martul is 23 years old. His wife is a student and he

  19. President Ilvese kohtumisel Poola riigipeaga keskenduti kahe riigi koostööle / Kristel Peterson

    Index Scriptorium Estoniae

    Peterson, Kristel

    2008-01-01

    Vabariigi President töövisiidil Poolas 1.-3.08.2008. Eesti riigipea kohtus Wislas Poola presidendi Lech Kaczynskiga, andis Varssavis Poola rezhissöörile Andrzej Wajdale üle Maarjamaa Risti teenetemärgi. Eesti ja Poola presidendid osalevad pidulikul tseremoonial Varssavi ülestõusu muuseumis, Eesti riigipea asetab lilled hiljuti hukkunud tuntud Poola ajaloolase ja poliitiku Bronislaw Geremeki hauale

  20. El Nacionalismo polaco a través de la película Kanal

    Directory of Open Access Journals (Sweden)

    Begoña GUTIÉRREZ SAN MIGUEL

    2014-10-01

    Full Text Available La película Kanal fue dirigida por Andrzej Wajda en el año 1957, basándose en un guión de Jerzy Stefan Stawinski y una interpretación a cargo de actores poco conocidos como Teresa Izewska Stokrotka (Daisy, Tadeusz Janczar Korab/Jacek Wienczyslaw Glinski Zabra, Tadeusz Gwiazdowski Kula (Bullet,Stanislaw Mikuldski Smukly (Slim, Emil Karewicz Madry (Wise, Wladyslaw Sheybal Michal Teresa Berezowska Halinka.

  1. Study protocol for the development of a European measure of best practice for people with long term mental health problems in institutional care (DEMoBinc)

    OpenAIRE

    Almeida, José Miguel Barros Caldas de

    2009-01-01

    BMC Psychiatry Killaspy, Helen King, Michael Wright, Christine White, Sarah McCrone, Paul Kallert, Thomas Cervilla, Jorge Raboch, Jiri Onchev, Georgi Mezzina, Roberto Wiersma, Durk Kiejna, Andrzej Ploumpidis, Dimitris Caldas de Almeida, Jose MiguelSixth Framework of the European Commission The study is funded by the Sixth Framework of the European Commission authors gratefully acknowledge this support. The authors would to acknowledge the contributions of the members of the International Expe...

  2. SIAM Conference on Applications of Dynamical Systems (8th) Held in Snowbird, Utah on 22-26 May 2005

    Science.gov (United States)

    2005-09-30

    were o Margaret Beck (Boston University) o Maria Leite (University of Houston) o Maria Carmen Romano and Marco Thiel (University of Potsdam) o Yulia...Barbara Oreste Piro, Universidad de las Islas Baleares, Spain "o Dynamical Systems and Industry: Dynamic Interactions - Parts I and II Andrzej Banaszuk...Young, New Jersey Institute of Technology Maria Higuera, Universidad Polit6cnica de Madrid, Spain "o Reduced Neuronal Models and Complex Neurodynamics

  3. Graph Structure Theory: Proceedings of a Joint Summer Research Conference on Graph Minors Held June 22 to July 5, 1991, at the University of Washington, Seattle. Contemporary Mathematics 147

    Science.gov (United States)

    1991-01-01

    Rudolf Miiller, A combinatorial approach to obtain bounds for stochastic project neworka, Tech. report, Technische Universitit Berlin, 1991. [Pou851 M...appear). 600 ANDRZEJ PROSKUROWSKI [201 J.A. Wald and C.J. Colbourn, Steiner trees, partial 2-trees, and minimum IFI networks, Networks 13 (1983), 159-167...Colbourn, Steiner trees, partial 2-trees and minimum IFI networks, Networks 13, (1983), 159-167. DEPARTMENT OF COMPUTER SCIENCE, UNIVERSITY OF

  4. Fluctuations and the QCD Phase Diagram

    CERN Document Server

    Koch, Volker

    2016-01-01

    In this contribution we will discuss how the study of various fluctuation observables may be used to explore the phase diagram of the strong interaction. We will briefly summarize the present study of experimental and theoretical research in this area. We will then discuss various corrections and issues which need to be understood and applied for a meaningful comparison of experimental measurements with theoretical predictions. This contribution is dedicated to Andrzej Bialas on the occasion of his $80^{\\mathrm{th}}$ birthday.

  5. Energy Efficiency in Computing (2/2)

    CERN Document Server

    CERN. Geneva

    2016-01-01

    We will start the second day of our energy efficient computing series with a brief discussion of software and the impact it has on energy consumption. A second major point of this lecture will be the current state of research and a few future technologies, ranging from mainstream (e.g. the Internet of Things) to exotic. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and initiated projects with the private sector (e.g. HP and Google), as well as international research institutes, such as EPFL. Currently, Andrzej acts as a consultant on technology and innovation with TIK Services (http://tik.services), and runs a peer-to-peer lending start-up. NB! All Academic Lectures are recorded. No webcast! Because of a problem of the recording equipment, this lecture will be repeated for recording pu...

  6. Energy Efficiency in Computing (1/2)

    CERN Document Server

    CERN. Geneva

    2016-01-01

    As manufacturers improve the silicon process, truly low energy computing is becoming a reality - both in servers and in the consumer space. This series of lectures covers a broad spectrum of aspects related to energy efficient computing - from circuits to datacentres. We will discuss common trade-offs and basic components, such as processors, memory and accelerators. We will also touch on the fundamentals of modern datacenter design and operation. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and initiated projects with the private sector (e.g. HP and Google), as well as international research institutes, such as EPFL. Currently, Andrzej acts as a consultant on technology and innovation with TIK Services (http://tik.services), and runs a peer-to-peer lending start-up. NB! All Academic L...

  7. Hadron Correlations at Energies from GeV to TeV

    Science.gov (United States)

    Kittel, W.

    One of the central issues in High Energy Physics is the close interchange between Theory and Experiment. Ever since I know Andrzej Bia{\\l}as, I know him as one of the theorists most interested in experimental data. This has naturally led to continuous fruitful contacts. Even though we have been working somehow together since about 1968, we so far have only one single publication in common. This was back in 1969 and it was on means to efficiently study what we then called (exclusive) Multihadron Final States. At that time this meant 3- or at best 4-particle final states of two-hadron collisions at cms energies of some 4 GeV (not TeV!). The field of multiparticle dynamics was in fact the domain of Polish high-energy physicists. The first of a very successful (and still lasting) series of annual International Symposia on Multiparticle Dynamics was organized in Paris in 1970, but essentially by Polish physicists. Andrzej himself was not attending, but it was he who organized the third in these series in (of course) Zakopane. Since heavy ion-collisions, another field of major interest for Andrzej, will be covered by others, I here will restrict myself mainly to the collisions of two elementary particles.

  8. Using principal component analysis to develop a single-parameter screening tool for metabolic syndrome

    Directory of Open Access Journals (Sweden)

    Yen Ching-Ho

    2010-11-01

    Full Text Available Abstract Background Metabolic syndrome (MS is an important current public health problem faced worldwide. To prevent an "epidemic" of this syndrome, it is important to develop an easy single-parameter screening technique (such as waist circumference (WC determination recommended by the International Diabetes Federation. Previous studies proved that age is a chief factor corresponding to central obesity. We intended to present a new index based on the linear combination of body mass index, and age, which could enhance the area under the receiver operating characteristic curves (AUCs for assessing the risk of MS. Methods The labour law of the Association of Labor Standard Law, Taiwan, states that employers and employees are respectively obligated to offer and receive routine health examination periodically. Secondary data analysis and subject's biomarkers among five high-tech factories were used in this study between 2007 and 2008 in northern Taiwan. The subjects included 4712 males and 4196 females. The first principal component score (FPCS and equal-weighted average (EWA were determined by statistical analysis. Results Most of the metabolic and clinical characteristics were significantly higher in males than in females, except high-density lipoprotein cholesterol level. The older group (>45 years had significantly lower values for height and high-density lipoprotein cholesterol level than the younger group. The AUCs of FPCS and EWA were significantly larger than those of WC and waist-to-height ratio. The low specificities of EWA and FPCS were compensated for by their substantially high sensitivities. FPCS ≥ 0.914 (15.4% and EWA ≥ 8.8 (6.3% were found to be the most prevalent cut off points in males and females, respectively. Conclusions The Bureau of Health Promotion, Department of Health, Taiwan, had recommended the use of WC ≥ 90 cm for males and ≥ 80 cm for females as singular criteria for the determination of central obesity instead

  9. Effect of Nuclear Reactions on the Properties of Al-Mg-Si Alloys after Long-Time Exploitation in Research Reactors

    CERN Document Server

    Hofmann, A; Szteke, W; Hajewska, E; Wagner, T; Semina, V K

    2004-01-01

    Effect of fast neutron ($E>$ 0.1~?eV) irradiation on the mechanical properties and fracture morphology of the Al-Mg-Si alloys (PAR-1 and ???-1) after 40 years of exploitation in research nuclear reactors has been studied. Tested specimens were cut from structural elements of reactor EWA ($\\acute{\\rm S}$wierk, Poland). Irradiation induces degradation in mechanical properties, namely yield strength and ultimate strength increase, but elongation reduces. The mechanical property changes are caused by ageing of Al--Mg--Si alloy. During irradiation Si is formed from Al by the Al($n, \\gamma $)Si reaction. The presence of Si might cause strengthening of the Al--Mg--Si alloys by increasing precipitation of Mg$_{2}$Si or pure Si in the Al matrix. Post-irradiation activity studies of EWA reactor structural elements show that the high-activity $^{60}$Co and $^{65}$Zn isotopes have been formed by the nuclear reactions.

  10. Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis

    DEFF Research Database (Denmark)

    Svendsen, Anders J; Gervin, Kristina; Lyle, Robert;

    2016-01-01

    OBJECTIVES: In an explorative epigenome-wide association study (EWAS) to search for gene independent, differentially methylated DNA positions and regions (DMRs) associated with rheumatoid arthritis (RA) by studying monozygotic (MZ) twin pairs discordant for RA. METHODS: Genomic DNA was isolated......: We identified several differentially methylated regions associated with RA, which may represent environmental effects or consequences of the disease and plausible biological pathways pertinent to the pathogenesis of RA....

  11. HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT

    OpenAIRE

    Shuo Wang; Jieyun Song; Yide Yang; Yining Zhang; Haijun Wang; Jun Ma

    2015-01-01

    Gene polymorphisms associated so far with body mass index (BMI) can explain only 1.18-1.45% of observed variation in BMI. Recent studies suggest that epigenetic modifications, especially DNA methylation, could contribute to explain part of the missing heritability, and two epigenetic genome-wide analysis studies (EWAS) have reported that Hypoxia Inducible Factor 3 Alpha Subunit (HIF3A) methylation was associated with BMI or BMI change. We therefore assessed whether the HIF3A methylation is as...

  12. Rim of the Pacific (RIMPAC). Programmatic Environmental Assessment

    Science.gov (United States)

    2002-06-01

    growth of benthic algae (limu). The Ewa - RIMPAC Programmatic EA 3-19 Beach area is a popular seaweed harvesting area on Oahu. Organisms offshore of...low numbers in the littoral waters. Macroalgae ( seaweed ) is very abundant in the offshore areas. (State of Hawaii, 2001) A diverse and abundant...organisms living in pelagic communities may be drifters ( plankton ) or swimmers (nekton). The plankton includes larvae of benthic species, so a pelagic

  13. Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants

    OpenAIRE

    Allum, Fiona; Shao, Xiaojian; Guénard, Frédéric; Simon, Marie Michelle; Busche, Stephan; Caron, Maxime; Lambourne, John; Lessard, Julie; Tandre, Karolina; Hedman, Åsa K.; Kwan, Tony; Ge, Bing; Rönnblom, Lars; McCarthy, Mark I; Deloukas, Panos

    2015-01-01

    This is the final version. It was first published by NPG at http://www.nature.com/ncomms/2015/150529/ncomms8211/full/ncomms8211.html#abstract Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach, methylC-capture sequencing (MCC-Seq), for sequenci...

  14. Comparison of projection skills of deterministic ensemble methods using pseudo-simulation data generated from multivariate Gaussian distribution

    Science.gov (United States)

    Oh, Seok-Geun; Suh, Myoung-Seok

    2017-07-01

    The projection skills of five ensemble methods were analyzed according to simulation skills, training period, and ensemble members, using 198 sets of pseudo-simulation data (PSD) produced by random number generation assuming the simulated temperature of regional climate models. The PSD sets were classified into 18 categories according to the relative magnitude of bias, variance ratio, and correlation coefficient, where each category had 11 sets (including 1 truth set) with 50 samples. The ensemble methods used were as follows: equal weighted averaging without bias correction (EWA_NBC), EWA with bias correction (EWA_WBC), weighted ensemble averaging based on root mean square errors and correlation (WEA_RAC), WEA based on the Taylor score (WEA_Tay), and multivariate linear regression (Mul_Reg). The projection skills of the ensemble methods improved generally as compared with the best member for each category. However, their projection skills are significantly affected by the simulation skills of the ensemble member. The weighted ensemble methods showed better projection skills than non-weighted methods, in particular, for the PSD categories having systematic biases and various correlation coefficients. The EWA_NBC showed considerably lower projection skills than the other methods, in particular, for the PSD categories with systematic biases. Although Mul_Reg showed relatively good skills, it showed strong sensitivity to the PSD categories, training periods, and number of members. On the other hand, the WEA_Tay and WEA_RAC showed relatively superior skills in both the accuracy and reliability for all the sensitivity experiments. This indicates that WEA_Tay and WEA_RAC are applicable even for simulation data with systematic biases, a short training period, and a small number of ensemble members.

  15. E-WASTE: ETHICAL IMPLICATIONS FOR EDUCATION AND RESEARCH

    OpenAIRE

    MUAZ HAWARI; MOHAMED H. HASSAN

    2010-01-01

    “E-waste” is a popular, informal name for electronic products nearing the end of their “useful life”. This includes discarded computers, televisions, VCRs, stereos, copiers, fax machines, electric lamps, cell phones, audio equipment and batteries. E-wastes are considered dangerous, as certain components of some of these electronic products contain materials; such as lead; that are hazardous, depending on their condition and density. If improperly disposed, E-wa...

  16. Ergonomic work analysis of urban bus drivers in Rio de Janeiro city.

    Science.gov (United States)

    Querido, Aloá; Nogueira, Tainan; Gama, Rafael; Orlando, José

    2012-01-01

    This article is the result of a case study on ergonomic work analysis carried out in an urban bus company located in Ilha do Governador, Rio de Janeiro. The methodology used in this work follows the French-tradition Ergonomic Analysis of the Work (EWA) combined with the best tradition from anglo-saxon ergonomic work analysis. The situated diagnosis was performed to provide relevant information about the work conditions of a bus driver.

  17. Radiation waste management in Poland; Unieszkodliwianie odpadow promieniotworczych w Polsce

    Energy Technology Data Exchange (ETDEWEB)

    Tomczak, W. [Institute of Atomic Energy, Otwock-Swierk (Poland)

    1995-12-31

    Radioactive waste management especially related to storage of spent fuel from Ewa and Maria research nuclear reactors has been presented. The classification and balance of radioactive wastes coming from different branches of nuclear activities have been shown. The methods of their treatment in respect of physical state and radioactive have been performed as well as their storage in Central Polish Repository have been introduced. 2 figs, 4 tabs.

  18. Analiza komparatystyczna wizerunku Beaty Szydło i Ewy Kopacz w debatach przedwyborczych

    Directory of Open Access Journals (Sweden)

    Barbara Mazurkiewicz-Białęcka

    2016-06-01

    Full Text Available Presented article is an attempt to comparative analysis the images of Szydło Beata and Ewa Kopacz in the election campaign preceding the general elections in 2015. The analysis refers, both to the image of the candidates, as well as to the role of women in politics in general, including the problem of stereotyping. The article also raised the issue of language, communication skills, mediatisation and trends within a run political campaigns.

  19. The complexity of epigenetic diseases.

    Science.gov (United States)

    Brazel, Ailbhe Jane; Vernimmen, Douglas

    2016-01-01

    Over the past 30 years, a plethora of pathogenic mutations affecting enhancer regions and epigenetic regulators have been identified. Coupled with more recent genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) implicating major roles for regulatory mutations in disease, it is clear that epigenetic mechanisms represent important biomarkers for disease development and perhaps even therapeutic targets. Here, we discuss the diversity of disease-causing mutations in enhancers and epigenetic regulators, with a particular focus on cancer.

  20. Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes.

    Science.gov (United States)

    Hannon, Eilis; Lunnon, Katie; Schalkwyk, Leonard; Mill, Jonathan

    2015-01-01

    Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant tissue is an important consideration for epigenome-wide association studies (EWAS). Little is known about whether easily accessible tissues, such as whole blood, can be used to address questions about interindividual epigenomic variation in inaccessible tissues, such as the brain. We quantified DNA methylation in matched DNA samples isolated from whole blood and 4 brain regions (prefrontal cortex, entorhinal cortex, superior temporal gyrus, and cerebellum) from 122 individuals. We explored co-variation between tissues and the extent to which methylomic variation in blood is predictive of interindividual variation identified in the brain. For the majority of DNA methylation sites, interindividual variation in whole blood is not a strong predictor of interindividual variation in the brain, although the relationship with cortical regions is stronger than with the cerebellum. Variation at a subset of probes is strongly correlated across tissues, even in instances when the actual level of DNA methylation is significantly different between them. A substantial proportion of this co-variation, however, is likely to result from genetic influences. Our data suggest that for the majority of the genome, a blood-based EWAS for disorders where brain is presumed to be the primary tissue of interest will give limited information relating to underlying pathological processes. These results do not, however, discount the utility of using a blood-based EWAS to identify biomarkers of disease phenotypes manifest in the brain. We have generated a searchable database for the interpretation of data from blood-based EWAS analyses ( http://epigenetics.essex.ac.uk/bloodbrain/).

  1. Comparison of projection skills of deterministic ensemble methods using pseudo-simulation data generated from multivariate Gaussian distribution

    Science.gov (United States)

    Oh, Seok-Geun; Suh, Myoung-Seok

    2016-03-01

    The projection skills of five ensemble methods were analyzed according to simulation skills, training period, and ensemble members, using 198 sets of pseudo-simulation data (PSD) produced by random number generation assuming the simulated temperature of regional climate models. The PSD sets were classified into 18 categories according to the relative magnitude of bias, variance ratio, and correlation coefficient, where each category had 11 sets (including 1 truth set) with 50 samples. The ensemble methods used were as follows: equal weighted averaging without bias correction (EWA_NBC), EWA with bias correction (EWA_WBC), weighted ensemble averaging based on root mean square errors and correlation (WEA_RAC), WEA based on the Taylor score (WEA_Tay), and multivariate linear regression (Mul_Reg). The projection skills of the ensemble methods improved generally as compared with the best member for each category. However, their projection skills are significantly affected by the simulation skills of the ensemble member. The weighted ensemble methods showed better projection skills than non-weighted methods, in particular, for the PSD categories having systematic biases and various correlation coefficients. The EWA_NBC showed considerably lower projection skills than the other methods, in particular, for the PSD categories with systematic biases. Although Mul_Reg showed relatively good skills, it showed strong sensitivity to the PSD categories, training periods, and number of members. On the other hand, the WEA_Tay and WEA_RAC showed relatively superior skills in both the accuracy and reliability for all the sensitivity experiments. This indicates that WEA_Tay and WEA_RAC are applicable even for simulation data with systematic biases, a short training period, and a small number of ensemble members.

  2. Effect of heartfulness meditation on burnout, emotional wellness, and telomere length in health care professionals.

    Science.gov (United States)

    Thimmapuram, Jayaram; Pargament, Robert; Sibliss, Kedesha; Grim, Rodney; Risques, Rosana; Toorens, Erik

    2017-01-01

    Background: Burnout poses significant challenges during training years in residency and later in the career. Meditation is a tool to treat stress-related conditions and promote wellness. Telomere length may be affected by burnout and stress. However, the benefits of meditation have not been fully demonstrated in health care professionals. Objective: We assessed the effects of a 12-week 'Heartfulness Meditation' program on burnout, emotional wellness, and telomere length in residents, faculty members, and nurses at a large community teaching hospital during the 2015-16 academic year. Methods: All subjects completed a baseline Maslach Burnout Inventory (MBI) and Emotional Wellness Assessment (EWA) at the beginning of the study. Meditators received instructions in Heartfulness Meditation. At week 12, subjects completed a follow up MBI and EWA scores. Salivary telomere length was measured at baseline and week 12. Results: Twenty-seven out of a total 155 residents (17.4%) along with eight faculty physicians and 12 nurses participated in the study. Thirty-five enrolled as meditators and 12 as controls. At 12 weeks, the meditators had statistically significant improvement in all measures of burnout and in nearly all attributes of EWA. Controls showed no statistically significant changes in either burnout or emotional wellness scores. Relative telomere length increased with statistical significance in a younger subset of meditators. Conclusion: Our results indicate that meditation offers an accessible and efficient method by which physician and nurse burnout can be ameliorated and wellness can be enhanced. The increased telomere length is an interesting finding but needs to be confirmed with further research. Abbreviations: EWA: Emotional wellness assessment; MBI: Maslach burnout inventory; EE: Emotional exhaustion; DP: Depersonalization; PA: Personal accomplishment; PI: Prinicipal investigator; JT: Jayaram Thimmapuram.

  3. Dramatic variations in emergent wetland area in China's largest freshwater lake, Poyang Lake

    Science.gov (United States)

    Mei, Xuefei; Dai, Zhijun; Fagherazzi, Sergio; Chen, Jiyu

    2016-10-01

    Freshwater wetlands are important ecosystems experiencing rapid degradation around the world. As much as 64% of world's wetland area has been lost since 1900; the situation is even more serious in Asia, where land reclamation and anthropogenic modifications of rivers are increasing the rate of wetland disappearance. In this study, we provide a first complete estimation of daily Emergent Wetland Area (EWA) in Poyang Lake, China's largest freshwater lake, from 1955 to 2012. A wavelet analysis indicates a strong periodicity in the monthly EWA time series with two oscillations having a period of 12 and 60-72 months, respectively. A dramatic increase in mean annual EWA is detected since 2003, when the Three Gorges Dam (TGD) was completed, mainly due to the seasonal drying of 1078 km2 of wetlands in October. It is found that the timing of wetland emergence during the dry season has been anticipated of one month, from November to October, since the establishment of TGD. It is argued that a significant increase in wetland exposure and an observable shift in the seasonal timing of flooding and drying will seriously degrade the wetland system and threaten the endangered migratory birds that inhabit it unless effective countermeasures are implemented.

  4. Ergonomic analysis in the manual transport of loads: a case study in a cement production company

    Directory of Open Access Journals (Sweden)

    Jarbas Rocha Martins

    2017-03-01

    Full Text Available This study aims to analyze the manual transport activity of 50kg bags in a cement production company by means of ergonomic work analysis (EWA, identifying environmental factors and loaders’ working conditions. In order for EWA to take place, photographic records, videos and interviews were performed. It covered aspects related to lifting, transportation and handling of cement bags, as well as observations of loaders’ posture while performing the activity. In this sense, both qualitative and quantitative aspects were taken into account, which were evidenced by the use of instruments for determining the concentration of agents in the environment. In addition, some management tools, such as the cause and effect diagram, and interviews conducted during the field research were used. It was found that the high rate of absenteeism in the activity is related to the strict control of productivity, the excessive lifting and manual transport of weights, and repetitive trunk flexion movements. The results shown by the EWA made it possible to propose preventive measures and some changes in the work environment.

  5. A Proxy Method for Estimation of EE-index using MAGDAS/CPMN Data

    Science.gov (United States)

    Ueno, T.; Yumoto, K.; Uozumi, T.; Numata, Y.; Group, M.

    2008-12-01

    EE-index (EDst, EU, and EL) is a new index proposed by Space Environment Research Center, Kyushu University (see Uozumi et al., 2008) to monitor temporal and long-term variations of the equatorial electrojet (EEJ). EU and EL mainly represent the range of EEJ and CEJ (equatorial counter electrojet) components, respectively. The baseline levels of EU and EL are obtained by averaging the H-component magnetic variations observed at the nightside (LT = 18-06) MAGDAS/CPMN stations along the magnetic equator. EDst, defined by Uozumi et al. (2008) fluctuates depending on the number of stations in the nightside sector (LT = 18-06). If the number is few, EDst may include some local fluctuations: the partial ring current component, substorm component and so on. Such local components cause some error in estimating the baseline level of EU or EL. Therefore, we need to use as many stations' data as possible in order to derive EU and EL properly. Pacific region is one of the most difficult areas to measure the magnetic field near the dip equator, because there are few islands. In the present paper, we developed a new method to use the data obtained from Ewa Beach (EWA; G. Lat. = 21.32N, G. Long. = 158.0W, Dip Lat. = 38.03), Hawaii, USA for estimation of EDst. EWA is not the equatorial station, but its nighttime H-component magnetic variations are found to be similar to those of Christmas Island (CXI; G. Lat. = 2.05N, G. Long. = 157.5W, Dip Lat. = 5.24), Kiribati. Data from EWA can be used as a proxy of that from CXI for monitoring temporal and long-term variations of the equatorial electrojet (EEJ) in real time. Acknowledgements: Authors appreciate Prof. Hisashi Utada of Earthquake Research Institute, University of Tokyo for supplying the magnetometer data from Christmas Island, Kiribati. Our deepest gratitude goes to all the members of the MAGDAS/CPMN project for their ceaseless support. Especially, we wish to thank the staffs of the observation stations: Dr. Baylie Damtie

  6. Zatrucie tlenkiem węgla – drogi narażenia, obraz kliniczny, metody leczenia = Carbon monoxide poisoning, routes of exposure, clinical manifestation, treatment

    OpenAIRE

    Sowa, Magdalena; Winnicki, Andrzej; Wójcik, Kamil; Tarkowski, Michał; Gnatowski, Tomasz

    2015-01-01

    Sowa Magdalena, Winnicki Andrzej, Wójcik Kamil, Tarkowski Michał, Gnatowski Tomasz. Zatrucie tlenkiem węgla – drogi narażenia, obraz kliniczny, metody leczenia = Carbon monoxide poisoning, routes of exposure, clinical manifestation, treatment. Journal of Education, Health and Sport. 2015;5(4):345-354. ISSN 2391-8306. DOI: 10.5281/zenodo.17251 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%284%29%3A345-354 https://pbn.nauka.gov.pl/works/556252 http://dx.doi...

  7. Projective limits of state spaces I. Classical formalism

    Science.gov (United States)

    Lanéry, Suzanne; Thiemann, Thomas

    2017-01-01

    In this series of papers, we investigate the projective framework initiated by Jerzy Kijowski (1977) and Andrzej Okołów (2009, 2013, 2014), which describes the states of a quantum (field) theory as projective families of density matrices. A short reading guide to the series can be found in [27]. The present first paper aims at clarifying the classical structures that underlies this formalism, namely projective limits of symplectic manifolds [27, subsection 2.1]. In particular, this allows us to discuss accurately the issues hindering an easy implementation of the dynamics in this context, and to formulate a strategy for overcoming them [27, subsection 4.1].

  8. Wybrane błędy językowe na przykładzie analizy funkcjonowania Poradni Językowej PWN

    Directory of Open Access Journals (Sweden)

    Katarzyna Ostrowska

    2016-03-01

    Full Text Available The article presents the theme of linguistic counseling and online guidance on the basis of Poradnia Językowa PWN. The primary aim of this essay is presenting problematic issues for contemporary Polish (wrong meanings of words: not in the least and at least, technique and technology, reliable, showing expert’s opinions and dictionary analysis (on the basis of Słownik języka polskiego edited by Witold Doroszewski and Wielki słownik poprawnej polszczyzny PWN edited by Andrzej Markowski.

  9. Heat transfer enhancement with nanofluids

    CERN Document Server

    Bianco, Vincenzo; Nardini, Sergio; Vafai, Kambiz

    2015-01-01

    Properties of NanofluidSamuel Paolucci and Gianluca PolitiExact Solutions and Their Implications in Anomalous Heat TransferWenhao Li, Chen Yang and Akira NakayamaMechanisms and Models of Thermal Conductivity in NanofluidsSeung-Hyun Lee and Seok Pil JangExperimental Methods for the Characterization of Thermophysical Properties of NanofluidsSergio Bobbo and Laura FedeleNanofluid Forced ConvectionGilles RoyExperimental Study of Convective Heat Transfer in NanofluidsEhsan B. Haghighi, Adi T. Utomo, Andrzej W. Pacek and Björn E. PalmPerformance of Heat Exchangers Using NanofluidsBengt Sundén and Za

  10. Physical rehabilitation of women after mastectomy

    OpenAIRE

    Korabiusz, Katarzyna; Wawryków, Agata; Torbé, Dorota; Janik, Inga; Torbé, Andrzej

    2017-01-01

    Korabiusz Katarzyna, Wawryków Agata, Torbé Dorota, Janik Inga, Torbé Andrzej. Physical rehabilitation of women after mastectomy. Journal of Education, Health and Sport. 2017;7(7):11-20. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.821838 http://ojs.ukw.edu.pl/index.php/johs/article/view/4575         The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Healt...

  11. Hadron Correlations at Energies from GeV to TeV

    OpenAIRE

    2016-01-01

    One of the central issues in High Energy Physics is the close interchange between Theory and Experiment. Ever since I know Andrzej Bia{\\l}as, I know him as one of the theorists most interested in experimental data. This has naturally led to continuous fruitful contacts. Even though we have been working somehow together since about 1968, we so far have only one single publication in common. This was back in 1969 and it was on means to efficiently study what we then called (exclusive) Multihadr...

  12. Video News Release WEB: CERN OPENLAB

    CERN Multimedia

    CERN Video productions

    2012-01-01

    New phase for Openlab 00 :00 -00 :11 : titres 00 :12 -00 : 38 : logo Openlab + footage CERN computing centre 00 :39- 01 :38 : interview of Bob Jones Head of CERN openlab 01 :39 – 01 :55 : footage computing centre 01 :56- 03 :09 : interview of Sverre Jarp , CERN openlab Chief Technology Officer 03 :10-04 :02 : footage technical rack computing centre 04 :03- 04 :56 : second interview of Sverre Jarp about éducation 04 :57- 05 :58 : interview of Andrzej Nowak staff researcher of CERN openlab 05 :59- END : others footage of computing center

  13. Rodzina w życiu wybitnych uczonych. Przykład Kazimierza Twardowskiego (1866–1938/Family in the life of distinguished scholars. The example of Kazimierz Twardowski (1866–1938

    Directory of Open Access Journals (Sweden)

    WŁADYSŁAWA SZULAKIEWICZ

    2012-01-01

    Full Text Available Kazimierz Twardowski is considered to be the creator of the Lvov-Warsaw philosophical school. Literature depicts him as an eminent scholar, teacher, organiser of scientific life. The subject of dissertation in this paper is an attempt to answer the following questions: What man was Kazimierz Twardowski like in everyday family life? What place did family occupy in his life? This sketch was prepared on the basis of Kazimierz Twardowski’s Diaries and an interview and conversations with his grandson professor Andrzej Tomczak, as well as the correspondence of K. Twardowski with his student Tadeusz Czeżowski.

  14. Supercomputing - Use Cases, Advances, The Future (1/2)

    CERN Document Server

    CERN. Geneva

    2017-01-01

    Supercomputing has become a staple of science and the poster child for aggressive developments in silicon technology, energy efficiency and programming. In this series we examine the key components of supercomputing setups and the various advances – recent and past – that made headlines and delivered bigger and bigger machines. We also take a closer look at the future prospects of supercomputing, and the extent of its overlap with high throughput computing, in the context of main use cases ranging from oil exploration to market simulation. On the first day, we will focus on the history and theory of supercomputing, the top500 list and the hardware that makes supercomputers tick. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and initiated projects with the private sector (e.g. HP an...

  15. LINAC4 takes a tour of Europe

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    Along the German Autobahnen, a truck carrying 20 tonnes of copper is on its way to Poland. The metal has already made a short tour of Europe, yet the drive across the high-speed highway is only the beginning of its transformation into CERN’s next linear accelerator, LINAC4.   Grzegorz Wrochna (left), director of the Andrzej Soltan Institute for Nuclear Studies (IPJ), and Rolf Heuer (right), CERN DG, sign the framework agreement between the two institutes. By the summer of 2012, the PI-Mode Structures (PIMS) will be constructed and completely installed in the LINAC4 tunnel. The PIMS cavities are the final accelerating structures needed for LINAC4, and have been designed to accelerate protons from 100 to 160MeV. While the first cavity was built entirely at CERN, construction of the remaining cavities has become a larger, multi-national operation. In a 1 million euro framework agreement signed on 11 February by the Director-General, the Andrzej Soltan Institute for Nuclear Studies in Swie...

  16. Future Computing Technology (1/3)

    CERN Document Server

    CERN. Geneva

    2015-01-01

    Computing of the future will be affected by a number of fundamental technologies in development today, many of which are already on the way to becoming commercialized. In this series of lectures, we will discuss hardware and software development that will become mainstream in the timeframe of a few years and how they will shape or change the computing landscape - commercial and personal alike. Topics range from processor and memory aspects, programming models and the limits of artificial intelligence, up to end-user interaction with wearables or e-textiles. We discuss the impact of these technologies on the art of programming, the data centres of the future and daily life. Lecturer's short bio: Andrzej Nowak has 10 years of experience in computing technologies, primarily from CERN openlab and Intel. At CERN, he managed a research lab collaborating with Intel and was part of the openlab Chief Technology Office. Andrzej also worked closely and initiated projects with the private sector (e.g. HP and Go...

  17. Hadron Correlations at Energies from GeV to TeV

    CERN Document Server

    Kittel, Wolfram

    2016-01-01

    One of the central issues in High Energy Physics is the close interchange between Theory and Experiment. Ever since I know Andrzej Bia{\\l}as, I know him as one of the theorists most interested in experimental data. This has naturally led to continuous fruitful contacts. Even though we have been working somehow together since about 1968, we so far have only one single publication in common. This was back in 1969 and it was on means to efficiently study what we then called (exclusive) Multihadron Final States. At that time this meant 3- or at best 4-particle final states of two-hadron collisions at cms energies of some 4 GeV (not TeV!). The field of multiparticle dynamics was in fact the domain of Polish high-energy physicists. The first of a very successful (and still lasting) series of annual International Symposia on Multiparticle Dynamics was organized in Paris in 1970, but essentially by Polish physicists. Andrzej himself was not attending, but it was he who organized the third in these series in (of cours...

  18. The doripenem serum concentrations in intensive care patients suffering from acute kidney injury, sepsis, and multi organ dysfunction syndrome undergoing continuous renal replacement therapy slow low-efficiency dialysis

    Directory of Open Access Journals (Sweden)

    Wieczorek A

    2014-10-01

    Full Text Available Andrzej Wieczorek, Andrzej Tokarz, Wojciech Gaszynski, Tomasz Gaszynski Department of Anesthesiology and Intensive Therapy, Medical University of Lodz, Lodz, Poland Abstract: Doripenem is a novel wide-spectrum antibiotic, and a derivate of carbapenems. It is an ideal antibiotic for treatment of serious nosocomial infections and severe sepsis for its exceptionally high efficiency and broad antibacterial spectrum of action. Doripenem is eliminated mainly by the kidneys. In cases of acute kidney injury, dosing of doripenem depends on creatinine clearance and requires adjustments. Doripenem is eliminated during hemodialysis because its molecular weight is 300–400 Da. The aim of this study was to establish the impact of continuous renal replacement therapy (CRRT slow low-efficiency dialysis (SLED on doripenem serum concentrations in a population of intensive-therapy patients with life-threatening infections and severe sepsis. Ten patients were enrolled in this observational study. Twelve blood samples were collected during the first administration of doripenem in a 1-hour continuous infusion while CRRT SLED was provided. Fluid chromatography was used for measurement of the concentration of doripenem in serum. In all collected samples, concentration of doripenem was above the minimum inhibition concentration of this antibiotic. Based on these results, we can draw the conclusion that doripenem concentration is above the minimum inhibition ­concentration throughout all of CRRT. The dosing pattern proposed by the manufacturer can be used in patients receiving CRRT SLED without necessary modifications. Keywords: AKI, antibiotic, antimicrobial therapy, carbapenem, CRRT, infection, MODS, SLED

  19. Distinct DNA methylation profiles in subtypes of orofacial cleft.

    Science.gov (United States)

    Sharp, Gemma C; Ho, Karen; Davies, Amy; Stergiakouli, Evie; Humphries, Kerry; McArdle, Wendy; Sandy, Jonathan; Davey Smith, George; Lewis, Sarah J; Relton, Caroline L

    2017-01-01

    Epigenetic data could help identify risk factors for orofacial clefts, either by revealing a causal role for epigenetic mechanisms in causing clefts or by capturing information about causal genetic or environmental factors. Given the evidence that different subtypes of orofacial cleft have distinct aetiologies, we explored whether children with different cleft subtypes showed distinct epigenetic profiles. In whole-blood samples from 150 children from the Cleft Collective cohort study, we measured DNA methylation at over 450,000 sites on the genome. We then carried out epigenome-wide association studies (EWAS) to test the association between methylation at each site and cleft subtype (cleft lip only (CLO) n = 50; cleft palate only (CPO) n = 50; cleft lip and palate (CLP) n = 50). We also compared methylation in the blood to methylation in the lip or palate tissue using genome-wide data from the same 150 children and conducted an EWAS of CLO compared to CLP in lip tissue. We found four genomic regions in blood differentially methylated in CLO compared to CLP, 17 in CPO compared to CLP and 294 in CPO compared to CLO. Several regions mapped to genes that have previously been implicated in the development of orofacial clefts (for example, TBX1, COL11A2, HOXA2, PDGFRA), and over 250 associations were novel. Methylation in blood correlated with that in lip/palate at some regions. There were 14 regions differentially methylated in the lip tissue from children with CLO and CLP, with one region (near KIAA0415) showing up in both the blood and lip EWAS. Our finding of distinct methylation profiles in different orofacial cleft (OFC) subtypes represents a promising first step in exploring the potential role of epigenetic modifications in the aetiology of OFCs and/or as clinically useful biomarkers of OFC subtypes.

  20. Efficient detection of differentially methylated regions using DiMmeR

    DEFF Research Database (Denmark)

    Almeida, Diogo Marinho; Skov, Ida; Silva, Artur

    2017-01-01

    MOTIVATION: Epigenome-wide association studies (EWAS) generate big epidemiological data sets. They aim for detecting differentially methylated DNA regions that are likely to influence transcriptional gene activity and, thus, the regulation of metabolic processes. The by far most widely used......MmeR computes empirical p-values through randomization tests, even for big data sets of hundreds of patients and thousands of permutations within a few minutes on a standard desktop PC. It is independent of any third-party libraries, computes regression coefficients, p-values and empirical p-values...

  1. The effect of grain size on the radiation hardening of austenic stainless steel 0H18N10T; Wplyw wielkosci ziarna na radiacyjne umocnienie stali austenitycznej 0H18N10T

    Energy Technology Data Exchange (ETDEWEB)

    Hofman, A.; Kochanski, T.; Malczyk, A. [Institute of Atomic Energy, Otwock-Swierk (Poland)

    1966-12-31

    The specimen of austenitic stainless steel 0H18N10T of solution annealed with different grain size and 30% cold worked were irradiated in Ewa reactor at 80 C to fluences up to 2 x 10{sup 23} n x m{sup 2} (E > 0.1 MeV). Post irradiation tensile test showed the change yield strength with grain size according to Hall-Peth`s equation. The radiation hardening of fine steel was weaker than that of steel with large grain size and is caused mainly by matrix hardening not by grain boundary hardening. (author). 10 refs, 4 figs, 4 tabs.

  2. Proceedings of the Workshop on Flight Testing to Identify Pilot Workload and Pilot Dynamics Held at the Edwards AFB, California on 19-21 January 1982

    Science.gov (United States)

    1982-05-01

    sophisticated ground based threats. The new MSIP III F-16s will have two multi-function displays, wide field of view hud, internal ECM, global positioning...be continued to check whether these data can be used to measure pilot workload. 326 tS, S I- 4-) 0S-o SI a, IT L) W- 0) 414- Ewa MS .--X F- D 327V 000...workload and stress. PURPOSE Night attack conducted at low-altitude is a primary thrust of many developing weapon systems (the B-l, F-16, MSIP , F-16E, F

  3. Efficient detection of differentially methylated regions using DiMmeR

    DEFF Research Database (Denmark)

    Almeida, Diogo Marinho; Skov, Ida; Silva, Artur;

    2016-01-01

    Regions), the first free standalone software that interactively guides with a user-friendly graphical user interface (GUI) scientists the whole way through EWAS data analysis. It offers parallelized statistical methods for efficiently identifying DMRs in both Illumina 450K and 850K EPIC chip data. Di......MmeR computes empirical p-values through randomization tests, even for big data sets of hundreds of patients and thousands of permutations within a few minutes on a standard desktop PC. It is independent of any third-party libraries, computes regression coefficients, p-values and empirical p...

  4. Retracted: Impact of polymorphisms in the oestrogen receptors alpha and beta (ESR1, ESR2) genes on risk of vasculogenic erectile dysfunction.

    Science.gov (United States)

    2014-01-01

    The above article from Andrology, 'Impact of polymorphisms in the oestrogen receptors alpha and beta (ESR1, ESR2) genes on risk of vasculogenic erectile dysfunction' by M. R. Safarinejad, A. Taghva, N. Shafiei and S. Safarinejad published online on 20 May 2013 in Wiley Online Library has been retracted by agreement between the journal Editors-in-Chief, Douglas Carrell and Ewa Rajpert-De Meyts and John Wiley and Sons Ltd. The retraction has been decided due to failure by the lead author to verify the data contained in the study, and to provide evidence of the role of co-authors and their institutional affiliations.

  5. Water Resources in Mid 21. Century in Slovenia - What can we expect according to regional climate predictions integrated into catchment hydrological modeling and modeling of soil water balance - an integration of top-down and bottom-up modeling approaches

    Science.gov (United States)

    Globevnik, Lidija; Vidmar, Andrej

    2015-04-01

    For the purpose of calculating the water balance in the soil, the European Environment Agency (EEA) produced a computational physical model "swbEWA" (Kurnik et al, 2013). It is designed to calculate the spatial distribution of water volume in the soil during the selected time period. Model accounts soil moisture by the addition and subtraction of the input parameters of water resources in the ground, which are expressed by the water column [mm]. Kurnik and Kajfež - Bogataj (2013) then used the model swbEWA to study the soil water balance parameters in Europe for the future. They used an ensemble of eight climate scenarios and analyzed the duration and size of agricultural drought across Europe. Surface runoff and deep percolation are two parameters of the water balance in the soil calculated by swbEWA model. They are expressed as mm of water column to the selected unit of modeled surface. The average values of monthly balance of the sum of the two quantities in the coming period 2021-2050 for selected river basins in Slovenia were compared with measured river flows in the reference periods 1961 - 1990 and 1981 - 2010. For comparison of results we have also calibrated semi-distributed HBV Light conceptual model for selected river basins and modeled catchment water-balance parameters for the period 2021-2050. As input we used the same rainfall and temperatures parameters as predicted by climatic scenarios used in the model swaEWA. Results Kurnik and Kajfež-Bogataj (2013) show that the largest increase by a lack of moisture in the soil occurred in the southwestern and southeastern Europe, where Slovenia does not fall. Changes will be in Slovenia still important. Employing the climatic scenario A1, the increase in soil moisture deficit relative to the reference period would be at least 0.45 during the period 2021-2050 (Kurnik and Kajfež -Bogataj, 2013), but the average annual run-off water in terms of average flow rates in 1961-1990 in Slovenia would decrease by 0

  6. Jllumina

    DEFF Research Database (Denmark)

    Almeida, Diogo Marinho; Skov, Ida; Lund, Jesper

    2016-01-01

    Measuring differential methylation of the DNA is the nowadays most common approach to linking epigenetic modifications to diseases (called epigenome-wide association studies, EWAS). For its low cost, its efficiency and easy handling, the Illumina HumanMethylation450 BeadChip and its successor, th...... HumanMethylation450 and Infinium MethylationEPIC BeadChip data, supporting the developer with Java functions covering reading and preprocessing the raw data, down to statistical assessment, permutation tests, and identification of differentially methylated loci....

  7. Projekt "Ersatz"

    Directory of Open Access Journals (Sweden)

    Sława Harasymowicz

    2015-05-01

    Full Text Available The article is a reflection on the exhibition entitled Ersatz, which took place in the Ethnographic Museum in Krakow. The subjective, creative interpretation of the partial archive material through retelling the story, as a part of discovering and reconstructing individual histories (microhistories connected with common history, is a proposition of a critical model of renegotiating the coexistence of postmemory and autobiographic memory, history with modern identity. Project was realised in curatiorial collaboration with Katarzyna Szydłowska and Konrad Schiller and Ewa Rossal (MEK.

  8. Hull early walking aid for rehabilitation of transtibial amputees--randomized controlled trial (HEART).

    Science.gov (United States)

    Mazari, Fayyaz Ali Khan; Mockford, Katherine; Barnett, Cleveland; Khan, Junaid A; Brown, Barbara; Smith, Lynne; Polman, Remco C; Hancock, Amanda; Vanicek, Natalie K; Chetter, Ian C

    2010-12-01

    To compare articulated and nonarticulated early walking aids (EWAs) for clinical and quality-of-life outcomes in transtibial amputees. Patients undergoing lower limb amputation in a tertiary-care vascular surgical unit were screened over a 4-year period. Recruited patients were randomized to receive articulated amputee mobility aid (AMA) or nonarticulated pneumatic postamputation mobility aid (PPAMA) during early rehabilitation. Primary (10-meter walking velocity) and secondary clinical (number and duration of physiotherapy treatments during EWA/prosthesis use) and quality-of-life (SF-36) outcome measures were recorded at five standardized assessment visits. Inter-group and intra-group analyses were performed. Two hundred seventy-two patients were screened and 29 transtibial amputees (median age, 56 years) were recruited (14/treatment arm). No significant difference was seen in demographics and comorbidities at baseline. Inter-group analysis: Median 10-meter walking velocity was significantly (Mann-Whitney, P = .020) faster in the PPAMA group (0.245 m/s, interquartile range [IQR] 0.218-0.402 m/s) compared with the AMA group (0.165 m/s; IQR, 0.118-0.265 m/s) at visit 1. However, there was no difference between the groups at any other visit. Similarly, the number of treatments using EWA was significantly (P = .045) lower in the PPAMA group (5.0; IQR, 3.5-8.0) compared with the AMA group (6.0; IQR, 6.0-10.5). No difference was observed between the groups in duration of physiotherapy or SF-36 domain and summary scores. Intra-group analysis: Both treatment groups showed significant improvement in 10-meter walking velocity (Friedman test; AMA P = .001; PPAMA P = .007); however, other clinical outcomes did not show any statistically significant improvement. Only physical function domain of SF-36 demonstrated significant improvement (Friedman test; AMA P = .037; PPAMA P = .029). There is no difference in clinical and QOL outcomes between articulated and nonarticulated EWAs

  9. Biomarkers intersect with the exposome.

    Science.gov (United States)

    Rappaport, Stephen M

    2012-09-01

    The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.

  10. On Relative Accessibility Depending on a Set of Parameters

    Institute of Scientific and Technical Information of China (English)

    张明义

    1989-01-01

    Ewa Orlowska[1,2] presented a class of relationsd-accessibiltiy relations determined by a set of parameters.These parameters are a formal counterpart of properties or characteristics of states which are associated by means of accessibility relation.The author has shown how properties of sets of parameters in fluence properties of accessibility relations and given interesting results.In this paper,some further algebraic properties of relative accessibility are discussed.We also give a necessary and sufficient condition,under which the set of accessibility relations({R (p)}pPAR forms a lattice by means of usual set operations.

  11. On Relative Accessibility Depending on a Set of Parameters

    Institute of Scientific and Technical Information of China (English)

    张明义

    1989-01-01

    Ewa Orlowska presented a class of relations-accessibility relatios determined by a set of parameters. These parameters are a formal counterpart of properties or characteristies of states which are associated by meaas of accessibility relation The author bas showu how properties of sets of parameters influence properties of accessibility relations and give in teresting results. In this paper, some fiurther algebraic properties of relative accessibility are diseussed. We also give a necessary and snfticient condition, under which the set of accessibility relations {R(P)} p包含于PAR forms a lattice by means of usual set operations.

  12. Response to “Oral health in the elderly patient and its impact on general well-being: a nonsystematic review” paper

    Directory of Open Access Journals (Sweden)

    Muc-Wierzgoń M

    2015-05-01

    Full Text Available Malgorzata Muc-Wierzgoń, Teresa Kokot, Ewa Nowakowska-Zajdel, Adam Błażelonis, Edyta Fatyga Department of Internal Medicine, Silesian Medical University, Bytom, PolandDear editorGil-Montoya et al has recently published an interesting article in Clinical Interventions in Aging entitled: “Oral health in the elderly patient and its impact on general well-being: a nonsystematic review”.1 Authors presented a non-systematic review of the published data regarding the oral health status of the elderly and its main repercussions, including its impact on general health and nutrition.View original paper by Gil-Montoya and colleagues.

  13. EDITORIAL: Microwave Moisture Measurements

    Science.gov (United States)

    Kaatze, Udo; Kupfer, Klaus; Hübner, Christof

    2007-04-01

    Microwave moisture measurements refer to a methodology by which the water content of materials is non-invasively determined using electromagnetic fields of radio and microwave frequencies. Being the omnipresent liquid on our planet, water occurs as a component in most materials and often exercises a significant influence on their properties. Precise measurements of the water content are thus extremely useful in pure sciences, particularly in biochemistry and biophysics. They are likewise important in many agricultural, technical and industrial fields. Applications are broad and diverse, and include the quality assessment of foodstuffs, the determination of water content in paper, cardboard and textile production, the monitoring of moisture in sands, gravels, soils and constructions, as well as the measurement of water admixtures to coal and crude oil in reservoirs and in pipelines. Microwave moisture measurements and evaluations require insights in various disciplines, such as materials science, dielectrics, the physical chemistry of water, electrodynamics and microwave techniques. The cooperation of experts from the different fields of science is thus necessary for the efficient development of this complex discipline. In order to advance cooperation the Workshop on Electromagnetic Wave Interaction with Water and Moist Substances was held in 1993 in Atlanta. It initiated a series of international conferences, of which the last one was held in 2005 in Weimar. The meeting brought together 130 scientists and engineers from all over the world. This special issue presents a collection of some selected papers that were given at the event. The papers cover most topics of the conference, featuring dielectric properties of aqueous materials, electromagnetic wave interactions, measurement methods and sensors, and various applications. The special issue is dedicated to Dr Andrzej W Kraszewski, who died in July 2006 after a distinguished career of 48 years in the research of

  14. Differentially methylated DNA regions in monozygotic twin pairs discordant for rheumatoid arthritis.An epigenome - wide study.

    Directory of Open Access Journals (Sweden)

    Anders Jørgen Svendsen

    2016-11-01

    Full Text Available Objectives: In an explorative epigenome-wide association study (EWAS to search for gene independent, differentially methylated DNA positions (DMPs and regions (DMRs associated with rheumatoid arthritis (RA by studying monozygotic (MZ twin pairs discordant for rheumatoid arthritis.Methods: Genomic DNA was isolated from whole blood samples from 28 monozygotic (MZ twin pairs discordant for RA. DNA methylation was measured using the HumanMethylation450 BeadChips. Smoking, anti-cyclic citrullinated peptide antibodies and immunosuppressive treatment were included as covariates. Pathway analysis was performed using GREAT.Results: Smoking was significantly associated with hypomethylation of a DMR overlapping the promoter region of the RNF5 and the AGPAT1, which are implicated in inflammation and autoimmunity, whereas DMARD treatment induced hypermethylation of the same region. Additionally, the promotor region of both S100A6 and EFCAB4B were hypomethylated and both genes have previously been associated with RA. We replicated several candidate genes identified in a previous EWAS in treatment naïve RA singletons. Gene set analysis indicated the involvement of immunologic signatures and cancer-related pathways in RA.Conclusion: We identified several differentially methylated regions associated with RA which may represent environmental effects or consequences of the disease and plausible biological pathways pertinent to the pathogenesis of rheumatoid arthritis

  15. Durability Choice Model of Durable Goods with Easy-to-Wear Accessories%存在易耗部件的耐用品的耐用度选择模型

    Institute of Scientific and Technical Information of China (English)

    苏昊; 谭德庆; 王艳

    2013-01-01

    Assuming a monopolist manufactures durable goods and easy-to-wear accessories (EWAs) of the durable product simultaneously. In order to study the monopolist's pricing and durability choice strategy, we build a two-period model. Through the model we find that Swan's market independence result cannot be extended to durable goods sellers. We also obtain the results about the mutual impact between the optimal durability of durable products and the durability of EWAs.%假设耐用品垄断厂商同时生产耐用品及其易耗部件两种产品,为了研究在存在易耗部件情况下,耐用品垄断厂商的销售定价和耐用度选择策略,建立了耐用品和易耗部件的需求-价格两期模型,通过模型可以发现,Swan的市场独立化的结论对于生产易耗部件的耐用品销售厂商不再成立.并且得到了在耐用品的销售市场中,耐用品垄断厂商所选择的耐用品的最优耐用度与易耗部件的耐用度之间互相影响的相关结论.

  16. Epigenetic signatures of internal migration in Italy.

    Science.gov (United States)

    Campanella, Gianluca; Polidoro, Silvia; Di Gaetano, Cornelia; Fiorito, Giovanni; Guarrera, Simonetta; Krogh, Vittorio; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Elliott, Paul; Matullo, Giuseppe; Chadeau-Hyam, Marc; Vineis, Paolo

    2014-10-15

    Observational studies have suggested that the risks of non-communicable diseases in voluntary migrants become similar to those in the host population after one or more generations, supporting the hypothesis that these diseases have a predominantly environmental (rather than inherited) origin. However, no study has been conducted thus far to identify alterations at the molecular level that might mediate these changes in disease risk after migration. Using genome-wide DNA methylation profiles from more than 1000 Italian participants, we conducted an epigenome-wide association study (EWAS) to identify differences between south-to-north migrants and their origin (southern natives) and host (north-western natives) populations. We identified several differentially methylated CpG loci, in particular when comparing south-to-north migrants with north-western natives. We hypothesise that these alterations may underlie an adaptive response to exposure differentials that exist between origin and host populations. Our study is the first large agnostic investigation of DNA methylation changes linked to migratory processes, and shows the potential of EWAS to investigate their biological effects. © The Author 2014; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

  17. Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

    Science.gov (United States)

    Allum, Fiona; Shao, Xiaojian; Guénard, Frédéric; Simon, Marie-Michelle; Busche, Stephan; Caron, Maxime; Lambourne, John; Lessard, Julie; Tandre, Karolina; Hedman, Åsa K; Kwan, Tony; Ge, Bing; Rönnblom, Lars; McCarthy, Mark I; Deloukas, Panos; Richmond, Todd; Burgess, Daniel; Spector, Timothy D; Tchernof, André; Marceau, Simon; Lathrop, Mark; Vohl, Marie-Claude; Pastinen, Tomi; Grundberg, Elin

    2015-05-29

    Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach, methylC-capture sequencing (MCC-Seq), for sequencing functional methylomes, while simultaneously providing genetic variation information. To illustrate MCC-Seq, we use whole-genome bisulfite sequencing on adipose tissue (AT) samples and public databases to design AT-specific panels. We establish its efficiency for high-density interrogation of methylome variability by systematic comparisons with other approaches and demonstrate its applicability by identifying novel methylation variation within enhancers strongly correlated to plasma triglyceride and HDL-cholesterol, including at CD36. Our more comprehensive AT panel assesses tissue methylation and genotypes in parallel at ∼4 and ∼3 M sites, respectively. Our study demonstrates that MCC-Seq provides comparable accuracy to alternative approaches but enables more efficient cataloguing of functional and disease-relevant epigenetic and genetic variants for large-scale EWAS.

  18. Launch of technical training courses for programmers

    CERN Multimedia

    2015-01-01

    This autumn, two new technical training courses have been launched for scientists and engineers at CERN who undertake programming tasks, particularly in C and C++. Both courses are taught by Andrzej Nowak, an expert in next-generation and cutting-edge computing technology research.   The training courses are organised in cooperation with CERN openlab and are sponsored by the CERN IT department – there is only a nominal registration fee of 50 CHF. This is an opportunity not to be missed! Computer architecture and hardware-software interaction (2 days, 26-27 October) The architecture course offers a comprehensive overview of current topics in computer architecture and their consequences for the programmer, from the basic Von Neumann schema to its modern-day expansions. Understanding hardware-software interaction allows the programmer to make better use of all features of available computer hardware and compilers. Specific architectural ...

  19. Awards aplenty in Krakow

    CERN Multimedia

    2009-01-01

    CERN will be well represented this year at the award ceremony organized by the European Physical Society (EPS) in Krakow. The Gargamelle Collaboration is being awarded the High Energy and Particle Physics prize, while Maurizio Pierini shares the Young Physicist Prize. Both Mick Storr and Andrzej Siemko will be awarded the Medal of the Polish Commission of National Education.This year’s EPS-High Energy and Particle Physics Prize is being awarded to the Gargamelle Collaboration for the discovery of the weak neutral current. Gargamelle’s large bubble chamber is now displayed in the Microcosm garden at CERN in commemoration of the discovery that led to the acceptance of the electroweak theory and the award of the Noble prize to Glashow, Salam and Weinberg in 1979. On 3 September 1973 the collaboration published two papers in the same issue of Physics Letters, one on neutral currents involving electrons, the other on neutral current interactions with hadrons (protons and neut...

  20. Gombrowicz a polski film fabularny

    Directory of Open Access Journals (Sweden)

    Jacek Nowakowski

    2013-01-01

    Full Text Available This article presents the influence that Witold Gombrowicz’s work has had on Polish cinema. It covers several generations of directors, for example, Andrzej Munk (born in the 1920s, Roman Polański and Jerzy Skolimowski (born in the 1930 as well as Agnieszka Holland, Piotr Szulkin and Marek Koterski (born in the 1940s and 1950s, and discusses the topic of film adaptations of his books (Jerzy Skolimowski’s Ferdydurke and Jan Jakub Kolski’s Pornografia [Pornography]. The article shows that Polish cinema uses Gombrowicz’s works most of all by taking up the issue of life’s authenticity and inauthenticity as well as to demythologize Polish tradition and history. As for esthetics, it employs Gombrowicz’s favorite style, i.e. the grotesque.

  1. Interactive granular computations in networks and systems engineering a practical perspective

    CERN Document Server

    Jankowski, Andrzej

    2017-01-01

    The book outlines selected projects conducted under the supervision of the author. Moreover, it discusses significant relations between Interactive Granular Computing (IGrC) and numerous dynamically developing scientific domains worldwide, along with features characteristic of the author’s approach to IGrC. The results presented are a continuation and elaboration of various aspects of Wisdom Technology, initiated and developed in cooperation with Professor Andrzej Skowron. Based on the empirical findings from these projects, the author explores the following areas: (a) understanding the causes of the theory and practice gap problem (TPGP) in complex systems engineering (CSE);(b) generalizing computing models of complex adaptive systems (CAS) (in particular, natural computing models) by constructing an interactive granular computing (IGrC) model of networks of interrelated interacting complex granules (c-granules), belonging to a single agent and/or to a group of agents; (c) developing methodologies based ...

  2. Ionization Cluster Size Distributions Created by Low Energy Electrons and Alpha Particles in Nanometric Track Segment in Gases

    CERN Document Server

    Bantsar, Aliaksandr

    2012-01-01

    The interaction of ionizing radiation with nanometric targets is a field of interest for many branches of science such as: radiology, oncology, radiation protection and nanoelectronics. A new experimental technique known as nanodosimetry has been developed for the qualitative as well as quantitative description of these types of interactions. The work presented here is a contribution to this development, namely by further improvement of the new experimental technique called the Jet Counter, originally developed at the Andrzej So{\\l}tan Institute for Nuclear Studies. The Jet Counter is a unique device in the world for studying the interaction of low energy electrons with nanometer targets in the range 2-10 nm (in unit density). The basic experimental result is the frequency distribution of ionization cluster size produced by ionizing particles in a gaseous (nitrogen or propane) nanometric track segment. The first experimental data on the frequency distribution of ionization cluster size produced by low energy ...

  3. Auhinnad 2009 - Nike ja Gdynia / Hendrik Lindepuu

    Index Scriptorium Estoniae

    Lindepuu, Hendrik, 1958-

    2009-01-01

    Poola tähtsaima kirjandusauhinna Nike sai 2009. aastal luuletaja Eugeniusz Tkaczyszyn-Dycki luulekogu "Piosenka o zależnościach i uzależnieniach" ("Laul sõltuvusest ja sõltumusest") eest. Teised kandidaadid olid: Andrzej Barti romaan "Fabryka muchołapek" ("Kärbsepiitsavabrik"), Ignacy Karpowiczi romaan "Gesty" ("Žestid"), Inga Iwasiówi romaan "Bambino", Bohdan Sławiński romaan "Królowa tiramisu" ("Tiramisu kuninganna"), Tomasz Piąteki romaan "Pałac Ostrogskich" ("Ostrogski loss") ja Krzystof Varga esseekogumik "Gulasz z turula" ("Turuguljašš"). Gdynia preemia luuleauhinna sai Eugeniusz Tkaczyszyn-Dycki luulekogu "Piosenka o zależnościach i uzależnieniach" ("Laul sõltuvusest ja sõltumusest"), proosapreemia sai Marcin Świetlicki romaan "Jedenście" ("Üksteist")

  4. Content and Symbolics of Polychromy in Cistercian Church in Jędrzejów (outline of issues

    Directory of Open Access Journals (Sweden)

    Lucyna Rotter

    2004-12-01

    Full Text Available A close theological and artistic co-operation has been observed in religious art since the Middle Ages. In the Baroque this co-operation was best revealed in monumental decorations inside churches. An example of it is the polychromy in the abbot church in Jędrzejów, whose author was Andrzej Radwański. Intention plan includes both theological content and issues connected with spirituality and activity of the Cistercian order. The history of the Jędrzejów Abbey was particularly emphasized and so was the person of the Blessed Wincenty Kadłubek, who was connected with it. A correlation between historical and symbolical depictions is very interesting; a method often used by Radwański in his monumental decorative painting.

  5. 8 February 2017 - Sri Lanka Hon. Minister of Science, Technology and Research A. D. S. Premajayantha signing the International Cooperation Agreement concerning Scientific and Technical Cooperation in High-Energy Physics 2017 with CERN Director for International Relations C. Warakaulle.

    CERN Multimedia

    Brice, Maximilien

    2017-01-01

    Were present: Hon. A. D. Susil Premajayantha, Minister of Science, Technology and Research, Democratic Socialist Republic of Sri Lanka; H.E. Mr Ravinatha Aryasinha, Ambassador, Permanent Representative of Sri Lanka to the UN in Geneva; Mrs Samantha Jayasuriya, Deputy Permanent Representative, Permanent Mission of Sri Lanka to the UN in Geneva; Ms Shashika Somaratne, Counsellor, Permanent Mission of Sri Lanka to the UN in Geneva; Mr Gihan Indragupta, Member of Sri Lanka Foreign service and Head of the G15 Secretariat; Ms Dilini Gunasekera, Second Secretary, Permanent Mission of Sri Lanka to the UN in Geneva; Mr Prageeth Herath , Supporting staff, Permanent Mission of Sri Lanka. CERN: Mr Andrzej Charkiewicz, CMS Ressources Manager; Ms Sofia Intoudi, Legal Officer; Dr Rüdiger Voss, Senior Adviser, International Relations; Ms Charlotte Warakaulle, Director for International Relations

  6. Confronting the Past

    DEFF Research Database (Denmark)

    Bondebjerg, Ib

    2013-01-01

    in quite another way than factual historical films. This article deals with some of the most important historical film genres and uses a general theory of genres, emotions, memory and history to analyse the historical films of Polish film director Andrzej Wajda, especially those made post 1989. Dealing......Historical films are important carriers of collective memory, and as a genre historical films can activate both strong feelings and strong debate. Historical fiction films often tell very accurate and almost documentary stories, but fictional films have the freedom to make historical reality...... with both his heritage drama Pan Tadeusz (1999) and critical historical drama Katyn (2007), the article analyses the ways in which Wajda uses historical narratives to comment on both history and contemporary society, and how this strategy is reflected in all his historical films. The article argues...

  7. Auhinnad 2009 - Nike ja Gdynia / Hendrik Lindepuu

    Index Scriptorium Estoniae

    Lindepuu, Hendrik, 1958-

    2009-01-01

    Poola tähtsaima kirjandusauhinna Nike sai 2009. aastal luuletaja Eugeniusz Tkaczyszyn-Dycki luulekogu "Piosenka o zależnościach i uzależnieniach" ("Laul sõltuvusest ja sõltumusest") eest. Teised kandidaadid olid: Andrzej Barti romaan "Fabryka muchołapek" ("Kärbsepiitsavabrik"), Ignacy Karpowiczi romaan "Gesty" ("Žestid"), Inga Iwasiówi romaan "Bambino", Bohdan Sławiński romaan "Królowa tiramisu" ("Tiramisu kuninganna"), Tomasz Piąteki romaan "Pałac Ostrogskich" ("Ostrogski loss") ja Krzystof Varga esseekogumik "Gulasz z turula" ("Turuguljašš"). Gdynia preemia luuleauhinna sai Eugeniusz Tkaczyszyn-Dycki luulekogu "Piosenka o zależnościach i uzależnieniach" ("Laul sõltuvusest ja sõltumusest"), proosapreemia sai Marcin Świetlicki romaan "Jedenście" ("Üksteist")

  8. Influence of Cracks on the Lifetime of Semi-Rigid Pavements

    Science.gov (United States)

    Kazimierowicz-Frankowska, Krystyna

    2016-12-01

    This paper focuses on a better understanding of the process of reflective cracking propagation through the pavement structure. A series of finite element numerical simulations were conducted to investigate the initial stress and strain states in typical semi-rigid pavements with and without reflective cracks under traffic loading. It was assumed that reflective-cracks propagate from the base layer to the pavement surface. The influence of selected parameters, such as the load position, overlay thickness, and subgrade quality on stress and strain concentrations was investigated. The behaviour of the pavement structure under repeated traffic loading was analyzed in terms of ground compaction. The original theoretical model proposed by Prof. Andrzej Sawicki was used to predict the deformation of a pavement subgrade subjected to traffic loading. The damaging effect of cracks appearing in the pavement structure was investigated. It was found that even a single crack in the pavement structure may significantly reduce the pavement lifetime.

  9. Confronting the Past

    DEFF Research Database (Denmark)

    Bondebjerg, Ib

    2013-01-01

    Historical films are important carriers of collective memory, and as a genre historical films can activate both strong feelings and strong debate. Historical fiction films often tell very accurate and almost documentary stories, but fictional films have the freedom to make historical reality...... in quite another way than factual historical films. This article deals with some of the most important historical film genres and uses a general theory of genres, emotions, memory and history to analyse the historical films of Polish film director Andrzej Wajda, especially those made post 1989. Dealing...... with both his heritage drama Pan Tadeusz (1999) and critical historical drama Katyn (2007), the article analyses the ways in which Wajda uses historical narratives to comment on both history and contemporary society, and how this strategy is reflected in all his historical films. The article argues...

  10. Development and validation of a computer-based learning module for wrist arthroscopy.

    Science.gov (United States)

    Obdeijn, M C; Alewijnse, J V; Mathoulin, C; Liverneaux, P; Tuijthof, G J M; Schijven, M P

    2014-04-01

    The objective of this study was to develop and validate a computer-based module for wrist arthroscopy to which a group of experts could consent. The need for such a module was assessed with members of the European Wrist Arthroscopy Society (EWAS). The computer-based module was developed through several rounds of consulting experts on the content. The module's learning enhancement was tested in a randomized controlled trial with 28 medical students who were assigned to the computer-based module group or lecture group. The design process led to a useful tool, which is supported by a panel of experts. Although the computer based module did not enhance learning, the participants did find the module more pleasant to use. Developing learning tools such as this computer-based module can improve the teaching of wrist arthroscopy skills.

  11. Emprego da análise ergonômica do trabalho em atividade com máquina agrícola motorizada

    Directory of Open Access Journals (Sweden)

    Ricardo Kozoroski Veiga

    2014-01-01

    Full Text Available In order to verify the constraints faced by farm workers who operate motorized agricultural machinery, an Ergonomic Workplace Analysis (EWA was performed in a federal school. The Pattern Nordic Questionnaire was applied to evaluate the physical conditions of the operator. The Moore and Garg Strain Index and the Rapid Upper Limb Assessment (RULA survey were used as observation protocols. The study was assisted by a number of computer programs: Ergolândia® (for the application of the National Institute for Occupational Safety and Health – NIOSH – equation, Antroprojeto® (estimated lengths of body parts, and Kinovea® (video editing for biomechanical analysis. After the application of the protocols, it was found that the activities of driving a power tiller, lifting chassis lids, and starting the engine manually demand immediate ergonomic intervention.

  12. General Aviation Activity and Avionics Survey 1982.

    Science.gov (United States)

    1983-12-01

    is F- C- i I.. <Z< 04K 4 K 4 K mm <.1 -.5 9.JO M 5 I. .J0 - AI. C 1.-’ 01- 1 0 0 -. t- 0 t- a 00 o 0 o0 mo0 w 0 is owe ao Ewa wm wo iso - 24 .0 4%~ 4...0540 41531 PCKARDV1650 49001 FRNKLN4AC50 27002 LYC 0540 41532 PWA 6T02 dT12 FRNKLN4AC0 27003 LYC 0540 41533 PWA JT12 52042 FRNKLN4AC10 27004 LYC 0540...41534 PWA OT15 52060 2RNKLN4ACI76 7009 LYC 0540 41535 PWA BT15 52 12 FRNLA 64 270073󈨋 FRNKLN4ACI7 27002 LYC 0540 41538 PWA IOT3C 4.T3C

  13. New insights and updated guidelines for epigenome-wide association studies

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    Lisa H. Chadwick

    2015-01-01

    Full Text Available Epigenetic dysregulation in disease is increasingly studied as a potential mediator of pathophysiology. The epigenetic events are believed to occur in somatic cells, but the limited changes of DNA methylation in studies to date indicate that only subsets of the cells tested undergo epigenetic dysregulation. The recognition of this subpopulation effect indicates the need for care in design and execution of epigenome-wide association studies (EWASs, paying particular attention to confounding sources of variability. To maximize the sensitivity of the EWASs, ideally, the cell type mediating the disease should be tested, which is not always practical or ethical in human subjects. The value of using accessible cells as surrogates for the target, disease-mediating cell type has not been rigorously tested to date. In this review, participants in a workshop convened by the National Institutes of Health update EWAS design and execution guidelines to reflect new insights in the field.

  14. Terra Foundation for American Art Europe

    Directory of Open Access Journals (Sweden)

    Géraldine Chouard

    2009-07-01

    Full Text Available Le 25 novembre 2008, à l'INHA, l'équipe de la Terra Foundation for American Art a annoncé ses nouveaux projets et notamment, à la suite de la fermeture du Musée d’art américain de Giverny, la création d'un centre parisien, situé dans le 2è arrondissement. Ce centre souhaite être, pour tous ceux que l'art américain intéresse, un nouveau lieu de ressources, d'échanges et de contacts.Sophie Lévy, Veerle Thielemans, Katherine Bourguignon, Ewa Bobrowska, Francesca Rose et Véronique Bossard ont tou...

  15. A simulation study on power of epigenome-wide association analysis using disease-discordant twin design

    DEFF Research Database (Denmark)

    Li, Weilong; Baumbach, Jan; Christiansen, Lene

    -control design, its statistical power has not been well investigated. Methods We perform a computer simulation study on the power of the disease discordant twin design assuming that both genetic and environmental factors contribute to the liability of a disease phenotype. Power is assessed under different levels......Background Identical twin pairs discordant for a disease have been widely used in epigenome-wide association studies (EWAS) of complex diseases because the underlying genetic background is cancelled out. Although the twin design is deemed to have enriched power as compared with ordinary case...... with moderate effect and for diseases with heritability>0.3. The power advantage in discordant twin design becomes more obvious with increasing heritability. For diseases with no genetic background, the twin design is slightly underpowered, while for high heritability (0.5), high intrapair methylation...

  16. Featured Image: The Birth of Spiral Arms

    Science.gov (United States)

    Kohler, Susanna

    2017-01-01

    In this figure, the top panels show three spiral galaxies in the Virgo cluster, imaged with the Sloan Digital Sky Survey. The bottom panels provide a comparison with three morphologically similar galaxies generated insimulations. The simulations run by Marcin Semczuk, Ewa okas, and Andrs del Pino (Nicolaus Copernicus Astronomical Center, Poland) were designed to examine how the spiral arms of galaxies like the Milky Way may have formed. In particular, the group exploredthe possibility that so-called grand-design spiral arms are caused by tidal effects as a Milky-Way-like galaxy orbits a cluster of galaxies. The authors show that the gravitational potential of the cluster can trigger the formation of two spiral arms each time the galaxy passes through the pericenter of its orbit around the cluster. Check out the original paper below for more information!CitationMarcin Semczuk et al 2017 ApJ 834 7. doi:10.3847/1538-4357/834/1/7

  17. Neutrino physics in the spotlight

    CERN Multimedia

    2009-01-01

    Following on from the Council recommendation made in Lisbon in 2006 and responding to the needs of a large community of scientists, CERN will organize the European Strategy for Future Neutrino Physics workshop on 1-3 October. One of the main goals of the workshop is to start establishing a roadmap for the coherent participation of Europe in neutrino physics."The format of the workshop will consist of invited talks to present the current situation and future possibilities; unlike other workshops, 30% of the time will be reserved for discussion", explains Ewa Rondio from the organising committee. "Resources for future neutrino experiments will be difficult to acquire. A coordinated approach and the participation of a large community of interested scientists are undoubtedly crucial factors". The workshop will be the opportunity to highlight the areas where substantial research and development activities are required in order to design the facilities of the next decade. "The w...

  18. Development of the cycloidal propeller StECon as a new small hydropower plant for kinetic energy

    Science.gov (United States)

    Schmidt, J.; Jensen, J.; Wieland, J.; Lohr, W.; Metzger, J.; Stiller, H.-L.

    2016-11-01

    The StECon (Stiller Energy Converter) is a promising new small hydropower plant for kinetic energy. It is an invention of Mr. Hans-Ludwig Stiller and has several advantages compared to the technologies for the use of hydropower known for millennia. It runs completely submerged forwards and backwards, with horizontal or vertical axis and has a compact design by using a single or a double-sided planetary gear with optimum alignment to the flow direction. The possible applications include mobile and stationary tide and current generators as well as hybrid solutions, either as a generator or as a propulsion system. The high expectations have to be confirmed in a research project StEwaKorad at the University of Siegen. Aim of this research project is to investigate the performance and characteristics of the StECon as an energy converter for producing renewable energy from hydropower with low fall heights including sea currents.

  19. A seismic refraction study of the crustal structure of the South Kenya Rift

    Science.gov (United States)

    Henry, W.; Mechie, J.; Maguire, P. K. H.; Patel, J.; Keller, G. R.; Prodehl, C.; Khan, M. A.

    This extended abstract of a forthcoming paper [Henry et al, unpublished manuscript] describes the results from the explosion part of the Kenya Rift International Seismic Project (KRISP 85). This consisted of two lines, each with 50 3-component recording stations [KRISP Working Group,1987; Henry, 1987]. Along the N-S line, the stations were deployed along the rift axis at 3.5 km intervals for about 200 km from Lake Baringo (BAR) to Susua (SUS) (Fig 1), with a few additional stations at the southern end of the line near Magadi (MAG). On the E-W line the stations were deployed at 1 km intervals from Mt. Margaret (MAR), beneath the eastern margin of the rift, westwards for 50 km to Ntulelei (NTU) at the western edge. A few additional stations were deployed further west to Ewaso Nyiro (EWA).

  20. SOCIAL PARTICIPATION IN THE ENVIRONMENTAL FLOW ASSESSMENT: THE SÃO FRANCISCO RIVER CASE STUDY

    Directory of Open Access Journals (Sweden)

    Yvonilde Dantas Pinto Medeiros

    2013-03-01

    Full Text Available Traditionally, water resource management has been developed using an essentially technical approach. Currently, public opinion on water resource management is formed as a result of growing environmental concerns and social conflicts arising from poorly planned actions. Environmental problems are complex and have multiple dimensions, including social and economic. Therefore, the inclusion of a human dimension in integrated assessment methodologies is required for the introduction of new elements to the water management planning process. Environmental water allocation (EWA is understood as the quantity, quality and distribution of water required for the maintenance of the functions and processes of aquatic ecosystems on which people depend. Within the various holistic assessment methodologies, the Building Block Methodology (BBM was found to be the most suitable, in the Brazilian context, for maintaining and restoring essential elements of the natural flow regime. This article describes the process of social participation in the environmental flow assessment (EFA for the Sao Francisco River, and compares it with some of the lessons learned from EFA in other parts of the world. The process involved multiple stakeholders who have conflicting interests. BBM was used to guide the field interviews, to incorporate the empirical observations by the local population and to guide the methodological procedures of the multidisciplinary team. The results of the study indicate the effectiveness of this holistic approach in organizing the elements to be evaluated. It also facilitated important contributions to the establishment of a dialogue between the actors to achieve a better understanding of the multiple aspects involved in the decisions associated with the EWA.

  1. Role of CO2 in the cerebral hyperemic response to incremental normoxic and hyperoxic exercise.

    Science.gov (United States)

    Smith, K J; Wildfong, K W; Hoiland, R L; Harper, M; Lewis, N C; Pool, A; Smith, S L; Kuca, T; Foster, G E; Ainslie, P N

    2016-04-15

    Cerebral blood flow (CBF) is temporally related to exercise-induced changes in partial pressure of end-tidal carbon dioxide (PetCO2 ); hyperoxia is known to enhance this relationship. We examined the hypothesis that preventing PetCO2 from rising (isocapnia) during submaximal exercise with and without hyperoxia [end-tidal Po2(PetO2 ) = 300 mmHg] would attenuate the increases in CBF. Additionally, we aimed to identify the magnitude that breathing, per se, influences the CBF response to normoxic and hyperoxic exercise. In 14 participants, CBF (intra- and extracranial) measurements were measured during exercise [20, 40, 60, and 80% of maximum workload (Wmax)] and during rest while ventilation (V̇e) was volitionally increased to mimic volumes achieved during exercise (isocapnic hyperpnea). While V̇ewas uncontrolled during poikilocapnic exercise, during isocapnic exercise and isocapnic hyperpnea, V̇ewas increased to prevent PetCO2 from rising above resting values (∼40 mmHg). Although PetCO2 differed by 2 ± 3 mmHg during normoxic poikilocapnic and isocapnic exercise, except for a greater poikilocapnic compared with isocapnic increase in blood velocity in the posterior cerebral artery at 60% Wmax, the between condition increases in intracranial (∼12-15%) and extracranial (15-20%) blood flow were similar at each workload. The poikilocapnic hyperoxic increases in both intra- and extracranial blood-flow (∼17-29%) were greater compared with poikilocapnic normoxia (∼8-20%) at intensities >40% Wmax(Pexercise influenced by the prevailing PetO2.

  2. Maternal Smoking during Pregnancy and DNA-Methylation in Children at Age 5.5 Years: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study

    Science.gov (United States)

    Rzehak, Peter; Saffery, Richard; Reischl, Eva; Covic, Marcela; Wahl, Simone; Grote, Veit; Xhonneux, Annick; Langhendries, Jean-Paul; Ferre, Natalia; Closa-Monasterolo, Ricardo; Verduci, Elvira; Riva, Enrica; Socha, Piotr; Gruszfeld, Dariusz; Koletzko, Berthold

    2016-01-01

    Mounting evidence links prenatal exposure to maternal tobacco smoking with disruption of DNA methylation (DNAm) profile in the blood of infants. However, data on the postnatal stability of such DNAm signatures in childhood, as assessed by Epigenome Wide Association Studies (EWAS), are scarce. Objectives of this study were to investigate DNAm signatures associated with in utero tobacco smoke exposure beyond the 12th week of gestation in whole blood of children at age 5.5 years, to replicate previous findings in young European and American children and to assess their biological role by exploring databases and enrichment analysis. DNA methylation was measured in blood of 366 children of the multicentre European Childhood Obesity Project Study using the Illumina Infinium HM450 Beadchip (HM450K). An EWAS was conducted using linear regression of methylation values at each CpG site against in utero smoke exposure, adjusted for study characteristics, biological and technical effects. Methylation levels at five HM450K probes in MYO1G (cg12803068, cg22132788, cg19089201), CNTNAP2 (cg25949550), and FRMD4A (cg11813497) showed differential methylation that reached epigenome-wide significance according to the false-discovery-rate (FDR) criteria (q-value<0.05). Whereas cg25949550 showed decreased methylation (-2% DNAm ß-value), increased methylation was observed for the other probes (9%: cg12803068; 5%: cg22132788; 4%: cg19089201 and 4%: cg11813497) in exposed relative to non-exposed subjects. This study thus replicates previous findings in children ages 3 to 5, 7 and 17 and confirms the postnatal stability of MYO1G, CNTNAP2 and FRMD4A differential methylation. The role of this differential methylation in mediating childhood phenotypes, previously associated with maternal smoking, requires further investigation. PMID:27171005

  3. Od melancholii do rozpaczy. O prozie Andrzeja Stasiuka

    Directory of Open Access Journals (Sweden)

    Claudia Snochowska-Gonzalez

    2014-06-01

    Full Text Available From melancholy to despair. About Andrzej Stasiuk’s prose works In Moja Europa, Jadąc do Babadag and Fado Andrzej Stasiuk describes his travelling to the countries of the East-Central Europe: its diminished, forgotten part, lying on the margins of History and Progress. It is a land of melancholy, of the eternal emptiness and lack. To praise it means to give an ironic response to the enthusiasm of a “return to the West”, to the attempts to meet East-European stigma and to the West’s fear of East-European ferocity. What is the source of this melancholy? Stasiuk refers to Cioran, his philosophy of history, his resignation and his belief in the bankruptcy of the European civilization. We know, however, that in the case of Cioran melancholy covers the memory of philosopher’s commitment to Romanian fascism; his subsequent melancholy replaces responsibility. What are the wounds and silenced victims hiding in Stasiuk’s melancholic landscape? What kind of responsibility does he not want to accept? In his next book, Dziennik pisany później, Stasiuk comes back to the same countries, this time not trying to escape the hell of questions about the East-European ethnic carnage. The author of the article analyses his turning point, using the terminology developed in Peter Hallward’s Absolutely Post-colonial to describe the dynamics between two tendencies: singular and specific.   Od melancholii do rozpaczy. O prozie Andrzeja Stasiuka W Mojej Europie, Jadąc do Babadag i Fado Andrzej Stasiuk podróżuje po krajach Europy Środkowo-Wschodniej. To Europa pomniejsza, zapomniana, na marginesie Historii i Postępu. Jest to kraina melancholii, pustki i wiecznego braku. Opiewanie jej staje się ironiczną odpowiedzią na entuzjazm „powrotu do Zachodu”, na próby sprostania wschodnioeuropejskiemu piętnu i na zachodnie przerażenie wschodnioeuropejską dzikością. Skąd się jednak bierze spowijająca ją melancholia? Stasiuk powołuje się na

  4. PREFACE: Joint European Magnetic Symposia - JEMS 2010

    Science.gov (United States)

    Spałek, Jozef

    2011-07-01

    łekChairman of JEMS 2010 Symposia 1. Plenary, Semi-plenary, Tutorials 2. Magnetization Processes Spin Excitations and Ultrafast DynamicsCoordinator: Andrzej Maziewski (Bialystok) 3. Hard Magnetic Materials and MagnetocaloricsCoordinator: Henryk Figiel (Kraków) 4. Magnetic HydridesCoordinators: Ladislav Havela (Praha), Zbigniew Tarnawski (Kraków) 5. Interface of Magnetic Thin FilmsCoordinators: Jürgen Fassbender (Dresden), N-T H Kim-Ngan (Kraków) 6. Magnonic CrystalsCoordinators: Bahram Djafari-Rouhani (Lille), Henryk Puszkarski (Poznan) 7. Magnetism of Metals, Alloys, and IntermetallicsCoordinator: Andrzej Szytula (Kraków) 8. Molecular MagnetismCoordinators: Stephen Blundell (Oxford), Maria Balanda (Kraków) 9. Magnetooptics of NanomagnetsCoordinators: Kamil Postava (Ostrava), Marek Kisielewski (Bialystok) 10. NanomagnetismCoordinators: Marek Przybylski (Halle), Jürgen Kirschner (Halle) 11. Other topics - Biomagnetism, Domain Walls, InstrumentationCoordinator: Henryk Figiel (Kraków) 12. Magnetic Perovskites and MultiferroicsCoordinator: Henryk Szymczak (Warszawa) 13. Magnetic Semiconductors and InsulatorsCoordinators: Klaus Baerner (Göttingen), Tadeusz Gron (Katowice) 14. Magnetic Shape Memory Effects and Related PhenomenaCoordinators: Oliver Gutfleisch (Dresden), Sebastian Fähler (Dresden) 15. Soft Magnetic MaterialsCoordinators: Julian González (San Sebastian), Krzysztof Kulakowski (Kraków) 16. SpintronicsCoordinator: Maciej Sawicki (Warszawa) 17. Strongly Correlated Electron Systems, Magnetism and SuperconductivityCoordinator: Andrzej Slebarski (Katowice) The next Joint European Magnetic Symposia, JEMS 2012, will be held in Parma, Italy, 9-14 September 2012.www.jems2012.itCo-Chairs:Franca Albertini, Institute of Materials for Electronics and Magnetism (IMEM), CNR, ParmaRoberto De Renzi, Department of Physics, University of Parma

  5. Les séries polonaises des années 1970 : entre contraintes politiques et censures génériques

    Directory of Open Access Journals (Sweden)

    Ania Szczepanska

    2011-04-01

    Full Text Available Dans les années 70, le directeur de la télévision polonaise lance la « propagande du succès », une ligne éditoriale censée refléter au petit écran la modernisation économique du pays. C’est à cette époque qu’est produite la série culte des Polonais : Le Quarantenaire. Dix ans plus tard et en plein état de guerre, une autre série connaîtra un grand succès, Jean le Cœur. Les deux séries sont produites par le groupe de production X, dirigé par Andrzej Wajda et connu au contraire pour ses films d’auteur du cinéma de l’inquiétude morale. Comment expliquer cette alliance inattendue entre télévision et cinéma ? Cette origine cinématographique a-t-elle marqué l’écriture filmique des deux séries télévisées ? La sérialité permet-elle de penser autrement la réalité socialiste ?In the seventies, the director of Polish Television launched the "success propaganda", an editorial line supposed to be the TV portrayal of the nation's economic modernisation. During that period the cult Polish series Middle-aged man [Czterdziestolatek] was produced. Ten years later, in the heat of the wartime period, another series had great success: John Heart [Jan Serce]. Both series were produced by the production group "X", headed by Andrzej Wajda, and were better known for producing independent films that were part and parcel of a cinema that expressed moral concern. How can this unexpected alliance between TV and the cinema be explained? Did the cinema-oriented producers influence the filmic grammar of the two series? Can cinematographers use the tools of TV series to express a socialist reality in a different way?

  6. Summary of my experiences as an undergraduate researcher in the U.S. and as a Fulbright Student Researcher at the Institute of Immunology and Experimental Therapy in Poland

    Directory of Open Access Journals (Sweden)

    Zelasko Susan

    2016-05-01

    Full Text Available Over the course of my undergraduate studies in Molecular and Cellular Biology and the experiences following my graduation, I became increasingly interested in research that can directly improve patient care. My research experiences in the U.S. include studying cytochrome P450 enzymes in Nanodiscs at the University of Illinois Urbana-Champaign and examining immune evasion by acute lymphoblastic leukemia cells at the University of Colorado Cancer Center. Beyond work in the laboratory, I also participated in a year-long project to implement a water delivery system in Honduras, leading to my interest in infectious disease research. My interest in this field grew after learning about phage therapy, a way of treating antibiotic-resistant infections, during an honors virology seminar. Only a few research groups are dedicated to studying phage therapy, which includes the Institute of Immunology and Experimental Therapy (IIET in Poland. I was fortunate enough to receive a U.S. Fulbright research grant to study the immune response to phage therapy under the mentorship of Prof. hab. n. med. Andrzej Górski at the IIET. In this article, I will discuss my involvement at U.S. and European institutions, the insights I have gained, and how other students can similarly get involved in research.

  7. The role of fluorescence diagnosis in clinical practice

    Directory of Open Access Journals (Sweden)

    Sieroń A

    2013-07-01

    Full Text Available Aleksander Sieroń,1 Karolina Sieroń-Stołtny,1 Aleksandra Kawczyk-Krupka,1 Wojciech Latos,1 Sebastian Kwiatek,1 Dariusz Straszak,1 Andrzej M Bugaj1,2 1Clinical Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Silesian Medical University, Bytom, 2College of Health, Beauty Care and Education, Poznan, Poland Abstract: Fluorescence diagnosis is a fast, easy, noninvasive, selective, and sensitive diagnostic tool for estimation of treatment results in oncology. In clinical practice the use of photodynamic diagnosis is focused on five targets: detection for prevention of malignant transformation precancerous changes, detection of neoplasmatic tissue in the early stages for fast removal, prevention of expansion and detection of recurrence of the cancer, monitoring therapy, and the possibility of excluding neoplasmatic disease. In this article, selected applications of fluorescence diagnosis at the Center for Laser Diagnostics and Therapy in Bytom, Poland, for each of these targets are presented. Keywords: autofluorescence, cancer, fluorescence, imaging, photodynamic diagnosis, photodynamic therapy 

  8. Antibiotic prophylaxis: different practice patterns within and outside the United States

    Directory of Open Access Journals (Sweden)

    Schwartz SG

    2016-01-01

    Full Text Available Stephen G Schwartz,1 Andrzej Grzybowski,2 Harry W Flynn Jr1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Department of Ophthalmology, Poznan City Hospital, Poznan, Poland Abstract: Endophthalmitis remains a rare but important cause of visual loss. Prophylaxis strategies are important to reduce rates of endophthalmitis after cataract surgery, intravitreal injection, and other procedures. There is substantial variability between the US and the rest of the world. During cataract surgery, intracameral antibiotics are commonly used in many nations, especially in Europe, but are less commonly used in the US. A randomized clinical trial from the European Society of Cataract and Refractive Surgeons reported an approximately fivefold reduction in endophthalmitis rates associated with intracameral cefuroxime but these results are controversial. There are no randomized clinical trials regarding endophthalmitis associated with intravitreal injection. Topical antibiotics are commonly used in many nations, but are less commonly used in the US. At this time, there is no global consensus and it appears unlikely that additional major clinical trials will conclusively define the optimal endophthalmitis prophylaxis techniques. Keywords: cataract surgery, endophthalmitis, intracameral antibiotic, intravitreal injection, prophylaxis

  9. Postural pattern recognition in children with unilateral cerebral palsy

    Directory of Open Access Journals (Sweden)

    Domagalska-Szopa M

    2014-02-01

    Full Text Available Małgorzata Domagalska-Szopa, Andrzej Szopa School of Health Sciences, Medical University of Silesia, Katowice, Poland Background: Several different strategies for maintaining upright standing posture in children with cerebral palsy (CP were observed. Purpose: The purpose of the present study was to define two different postural patterns in children with unilateral CP, using moiré topography (MT parameters. Additionally, another focus of this article was to outline some implications for managing physiotherapy in children with hemiplegia. Patients and methods: The study included 45 outpatients with unilateral CP. MT examinations were performed using a CQ Elektronik System device. In addition, a weight distribution analysis on the base of support between unaffected and affected body sides was performed simultaneously. A force plate pressure distribution measurement system (PDM-S with Foot Print software was used for these measurements. Results: The cluster analysis revealed four groups: cluster 1 (n=19; 42.22%; cluster 2 (n=7; 15.56%; cluster 3 (n=9; 20.00%; and cluster 4 (n=10; 22.22%. Conclusion: Based on the MT parameters (extracted using a data reduction technique, two postural patterns were described: 1 the pro-gravitational postural pattern; and 2 the anti-gravitational pattern. Keywords: deviation of body posture, strategy of compensation, moiré topography examinations, cluster analysis

  10. Radiotherapy combined with hormonal therapy in prostate cancer: the state of the art

    Directory of Open Access Journals (Sweden)

    Piotr Milecki

    2010-10-01

    Full Text Available Piotr Milecki1,2, Piotr Martenka1, Andrzej Antczak3, Zbigniew Kwias31Department of Radiotherapy, Greater Poland Cancer Center, Poznan, Poland; 2Department of Electroradiology, Medical University, Poznan, Poland; 3Chair of Urology, Medical University, Poznan, PolandAbstract: Androgen-deprivation therapy (ADT is used routinely in combination with definitive external beam radiation therapy (EBRT in patients with high-risk clinically localized or locally advanced disease. The combined treatment (ADT–EBRT also seems to play a significant role in improving treatment results in the intermediate-risk group of prostate cancer patients. On the other hand, there is a growing body of evidence that treatment with ADT can be associated with serious and lifelong adverse events including osteoporosis, cardiovascular disease, diabetes, and many others. Almost all ADT adverse events are time dependant and tend to increase in severity with prolongation of hormonal manipulation. Therefore, it is crucial to clearly state the optimal schedule for ADT in combination with EBRT, that maintaining the positive effect on treatment efficacy would keep the adverse events risk at reasonable level. To achieve this goal, treatment schedule may have to be highly individualized on the basis of the patient-specific potential vulnerability to adverse events. In this study, the concise and evidence-based review of current literature concerning the general rationales for combining radiotherapy and hormonal therapy, its mechanism, treatment results, and toxicity profile is presented.Keywords: prostate cancer, radiotherapy, androgen deprivation, combined treatment

  11. Light transport in long, plastic scintillators

    Energy Technology Data Exchange (ETDEWEB)

    Gierlik, M. [Soltan Institute for Nuclear Studies, PL 05-400 Swierk-Otwock (Poland)], E-mail: m.gierlik@ipj.gov.pl; Batsch, T.; Marcinkowski, R.; Moszynski, M.; Sworobowicz, T. [Soltan Institute for Nuclear Studies, PL 05-400 Swierk-Otwock (Poland)

    2008-08-11

    As a form of the input into the collaboration the group from the Andrzej Soltan Institute for Nuclear Studies undertook a task of investigating the validity of the design of a compact detector for Gamma Ray Bursts photon polarization measurements, known as POLAR. The authors focused at the scintillation and light transport properties of (200x6x6)mm{sup 3} BC400 plastic bars as well as of other samples of BC408 plastic in the attempt to determine whether the assembled instrument is going to achieve the performance criteria bestowed upon it by the project. The investigation revealed a strong dependence between the amplitude of a signal and distance between the precursor interaction in a scintillator and the photodetector. Accordingly to this finding an attempt has been made to determine the influence of the surface polishing quality on the overall scintillator performance. The authors consider that proper machining of scintillator pieces, adequate choice of their packaging, and proper software analysis may overcome the revealed disadvantages.

  12. Cine club

    CERN Multimedia

    Cine club

    2015-01-01

    Wednesday 13 May 2015 at 20:00 CERN Council Chamber Read My Lips Directed by Jacques Audiard France, 2001, 105 minutes   Young secretary Carla is a long-time employee of a property development company. Loyal and hardworking, first to arrive and last to leave, Carla is beginning to chafe at the limitations of her career and is looking to move up. But as a 35-five-year-old woman with a hearing deficiency, she is not sure how to climb out of her humdrum life, though she is confident in her own abilities. Into her life comes Paul Angeli, a new trainee she decides to hire. Paul is 25 years old and completely unskilled, but Carla covers for him when the need arises because of his other qualities - he's a thief, fresh out of jail and very good-looking. It's a case of good meeting bad. Original version French; English subtitles   Wednesday 20 May 2015 at 20:00 CERN Council Chamber Imagine Directed by Andrzej Jakimowski Poland, 2012, 105 minutes Set in Lisbon, at an ...

  13. Academic Training Lectures | Introduction to Parallelism, Concurrency and Acceleration | 19-20 January

    CERN Multimedia

    2016-01-01

    Please note that the next series of Academic Training Lectures will take place on 19 and 20 January 2016. The lectures will be given by Andrzej Nowak (TIK Services, Switzerland).   An Introduction to Parallelism, Concurrency and Acceleration (1/2) on Tuesday, 19 January from 11 a.m. to 12 noon https://indico.cern.ch/event/404682/ An Introduction to Parallelism, Concurrency and Acceleration (2/2) on Wednesday, 20 January from 11 a.m. to 12 noon https://indico.cern.ch/event/404683/ at CERN IT Amphitheatre (31-3-004) Description: Concurrency and parallelism are firm elements of any modern computing infrastructure, made even more prominent by the emergence of accelerators. These lectures offer an introduction to these important concepts. We will begin with a brief refresher of recent hardware offerings to modern-day programmers. We will then open the main discu...

  14. Digitisation and public accessibility of old Polish guides on self-treatment and quality-of-life improvement

    Directory of Open Access Journals (Sweden)

    Joanna Nowak

    2017-06-01

    Full Text Available This letter to the Editor can prove useful as a mini-guide. Interest in health and quality of life is continuing to grow in the second decade of the 21st century, both among professionals actively involved in giving advice to others and among diverse social groups, as well as individually, among those sick and those healthy. Along with recent novelties, traditional Old Polish methods also feature prominently in discussions, but those interested know relatively little about how to access source materials. This letter therefore describes the possibilities for open access to Polish-language health guides from the Renaissance and Baroque era, whose authors included medical doctors and which focused on describing food and herbs used in self-treatment and promoting the healthy life style of the period. The works of Andrzej from Kobylin, Zawacki, Śleszkowski, Olszowski and Haur are briefly described and information is given about their availability in full-text on-line data bases.

  15. Around the Globe with Buzz Aldrin

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    Buzz Aldrin! The news caused a sensation: his arrival was imminent. The man who, 40 years ago, first step foot on the moon, was to do the same at CERN.   Buzz Aldrin dumps the pilot beams from the LHC. Visiting the Globe on 1 March to endorse General Motors’ (GM) new ecological programme, Buzz Aldrin took advantage of the occasion to take a whistle-stop tour of the Organisation. “CERN is dealing with things going very fast underground; I’m dealing with things going fast – not that fast though! – up in orbit,” he said. Accompanied by his wife Lois and singer Katie Melua - also invited by GM to perform at the private event - Buzz began his visit with a short introduction to CERN at the Universe of Particles exhibit. He then met with Andrzej Siemko, group leader of the LHC machine protection, at the SM-18 super conducting magnet test facility. The astronaut’s last stop was at the CCC, where the LHC team had somethi...

  16. The Attractive Banality of Natalia LL’s "Consumer Art” (1972–1975

    Directory of Open Access Journals (Sweden)

    Agata Jakubowska

    2007-05-01

    The work was created in the neo-avant-garde circles and was in those circles perceived as "an exploration of morphological potential of the sign and the capacity of the medium" (Andrzej Lachowicz. Simultaneously it functioned in the sphere of feminist art, into which it was included in the 1970's by feminist researchers from the Western Europe. In the present article the author conducts an analysis of the ambivalence resulting from the inclusion, which is caused by, among other factors, the incompatibility of Western discourse to Polish situation. It is also pointed out that it is only in the second half of the 1990's that the feminist discourse re-appears in the declarations of the artist herself and of some critics, which is related to the shift, observable in their texts, of "Consumer Art" from the area of conceptual art to the area of body art. The author enters a polemic with some elements of those interpretations, e. g. those referring to the critique of consumerism, and proposes to concentrate on the work by Natalia LL as one referring to erotic desire and female pleasure as issues which had no proper place in the mainstream culture (in the case of Natalia LL, the culture of the Polish Republic of Poland. In this context the author recalls the contemporary pastiche of Natalia LL's work, "Try this!" (2006 by Karol Radziszewski.

  17. The philosophy of mathematics and logic in the 1920s and 1930s in Poland

    CERN Document Server

    Murawski, Roman

    2014-01-01

    The aim of this book is to present and analyze philosophical conceptions concerning mathematics and logic as formulated by Polish logicians, mathematicians and philosophers in the 1920s and 1930s. It was a remarkable period in the history of Polish science, in particular in the history of Polish logic and mathematics. Therefore, it is justified to ask whether and to what extent the development of logic and mathematics was accompanied by a philosophical reflection. We try to answer those questions by analyzing both works of Polish logicians and mathematicians who have a philosophical temperament as well as their research practice. Works and philosophical views of the following Polish scientists will be analyzed: Wacław Sierpiński, Zygmunt Janiszewski, Stefan Mazurkiewicz, Stefan Banach Hugo Steinhaus, Eustachy Żylińsk and Leon Chwistek, Jan Łukasiewicz, Zygmunt Zawirski, Stanisław Leśniewski, Tadeusz Kotarbiński, Kazimierz Ajdukiewicz, Alfred Tarski, Andrzej Mostowski and Henryk Mehlberg, Jan Sleszyńs...

  18. Meeting report for Odd Pols 2016: Ann Arbor 2.0.

    Science.gov (United States)

    Roy-Engel, Astrid M

    2017-05-15

    The Tenth International Conference on Transcription by RNA Polymerases I, III, IV and V (the 'Odd Pols') was held June 24-28, 2016 at the University of Michigan, Ann Arbor, USA and organized by David Engelke, Deborah Johnson, Richard Maraia, Lawrence Rothblum, David Schneider, Andrzej Wierzbicki and Astrid Engel. The organizers are grateful for the support from the Rackham Graduate School of the University of Michigan for providing the meeting venue. The environment provided a great background with unexpected encounters with fireflies, free live music and a festive fireworks display. The meeting was composed of eleven oral sessions and a poster session. The keynote speaker, Dave Engelke, opened the meeting with his presentation entitled "A personal history of pol III transcription - how we got here from the 'good old days'." The meeting drew attendees from sixteen countries that shared their research discoveries. Here we present some of the highlights from the meeting using summaries provided by the participants. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. DOOM:The Movie

    Institute of Scientific and Technical Information of China (English)

    高达X

    2005-01-01

    片名:毁灭战士导演:安德列·巴柯维亚\\Andrzej Bartkowiak编剧:韦斯利·斯特里克Wesley Strick\\戴夫·卡拉汉Dave Callaham主演:卡尔·厄班Karl Urban\\巨石强森Dwayne Johnson\\罗莎蒙德·派克Rosamund Pike迪奥比亚·奥派雷Deobia Oparei\\本·丹尼尔斯Ben Daniels类型:动作\\冒险也许谁都没想到,从终典FPS游戏《Doom》系列脱胎而来的电影《Doom》,能在10月第三周占据北美电影票房top10排行榜第一的位置,虽然秋季是北美电影的萧条期,虽然《Doom》甚至没能在榜上呆上一周,但是上映3天1500万美元的成绩也算差强人意,尤其是在《最终幻想》、《生化危机》等游戏改编电影纷纷惨败的背景下史更显难得

  20. Sublimation TiN Coating of RF Power Components

    Science.gov (United States)

    Lorkiewicz, J.; Kula, J.; Pszona, S.; Sobczak, J.; Bilinski, A.

    2008-03-01

    Titanium evaporation in a reactive atmosphere of ammonia has been chosen to deposit thin (up to 10 nm) protective surface layers containing titanium nitride and titanium oxinitrides which suppress secondary electron emission. The coating procedure, applied by the author in DESY (Hamburg) for TESLA couplers anti-multipactor protection, has been recently implemented in The Andrzej Soltan Institute for Nuclear Studies (IPJ) where a new coating device is used, equipped with a special titanium sublimation setup in a 100 1 vacuum chamber. Several arrays of cylindrical and coaxial RF coupler windows have been coated so far after optimizing the processing parameters. A check of the obtained surface layers ability to attenuate secondary electron emission has been performed; measurements of the secondary electron yield from TiN layers deposited on alumina samples were done in IPJ on as-delivered coated samples, then after vacuum bake-out and finally after additional electron bombardment of their surfaces. Also chemical composition of the surface layers has been studied using XPS in the Institute of Physical Chemistry (IChF).

  1. Mammalian and avian embryology at Warsaw University (Poland) from XIX century to the present.

    Science.gov (United States)

    Tarkowski, Andrzej K; Maleszewski, Marek; Rogulska, Teresa; Ciemerych, Maria A; Borsuk, Ewa

    2008-01-01

    In this article, we describe the history (between the XIX century and World War II) of embryological research conducted at Warsaw University, together with current research activities being carried out at the Department of Embryology. During the partition of Poland, the Imperial (Russian) Warsaw University conducted research on avian embryology (and to a smaller extent, on reptilian embryology). When Poland regained independence in 1918, these studies were continued under the Chair of Comparative Anatomy headed by Professor Jan Tur. A new Department of Embryology created in 1954 was first headed by Professor Stanislaw Bilewicz and since 1964 by Professor Andrzej Tarkowski, who in 2003 was succeeded by Dr. Marek Maleszewski D.Sc. During the last 45 years, embryological research at Warsaw University has concentrated mainly on mammalian development with special emphasis on the regulative capabilities of early embryos and also on experimental chimaeras, nucleo-cytoplasmic interactions in oogenesis and early embryogenesis (including regulation of DNA replication and transcription), experimental parthenogenesis and fertilization.

  2. Multimedia and Internet Systems Theory and Practice

    CERN Document Server

    Choroś, Kazimierz; Siemiński, Andrzej

    2013-01-01

    Aleksander Zgrzywa,  Kazimierz Choroś, and  Andrzej Siemiński (Eds.) Multimedia and Internet Systems: Theory and Practice     During the last 20 years we have witnessed a rapid development of Multimedia and Network Information Systems. What is even more important, the pace of change does not show any sign of slowing. When we look back we see how many research projects that have originated at various universities or in research facilities are now part of our everyday life. This monograph offers the reader a very broad review of the most recent scientific investigations in that area. The book is a collection of carefully selected and the most representative investigations, solutions, and applications presented by scientific teams from several countries. The content of the monograph has been divided into four parts: 1.  Multimedia Information Technology 2.  Information Systems Specification 3.  Information Systems Applications 4.  Web Systems and Network Technologies The book is aiming to attract more ...

  3. Annual report 1997

    Energy Technology Data Exchange (ETDEWEB)

    Chmielewska, D.; Infeld, E.; Zupranski, P. [eds.

    1998-12-31

    In the presented ``Annual Report 1997`` the scientific, organizational end educational activities of the Andrzej Soltan Institute for Nuclear Studies (SINS) are presented. The document is divided into two parts. First of them consist of the general information about management, scientific council, department of SINS, scientific staff, visiting scientists, list of research project (grants), PhD and DSc theses as well as the information about organized schools and exhibitions. The second one: ``Reports on Research`` describes the research activities of SINS. It is divided into 12 parts - in which the works of SINS departments and establishments are presented (Department of Nuclear Reactions, Department of Nuclear Spectroscopy and Technique, Department of Nuclear Electronics, Department of Radiation Shielding and Dosimetry, Department of Plasma Physics and Technology, Department of High Energy Physics, Department of Cosmic Radiation Physics, Department of Atomic Nucleus Theory, Department of Radiation Detectors, Department of Accelerator Physics and Technology, Department of Training an Consulting and Establishment for Nuclear Equipment). Each of these parts are foreworded by short overview given by the head of appropriate department. The foreword, in which the whole activities of the SINS are summarized, given by head of the Institute professor Z. Sujkowski is also given

  4. Annual Report 1998

    Energy Technology Data Exchange (ETDEWEB)

    Chmielewska, D.; Infeld, E.; Preibisz, Z.; Zupranski, P. [eds.

    1999-10-01

    In the presented ``Annual Report 1998`` the scientific, organizational and educational activities of the Andrzej Soltan Institute for Nuclear Studies (SINS) are presented. The document is divided into two parts. First of them consists of the general information about management, scientific council, department of SINS, scientific staff, visiting scientists, list of research project (grants), PhD and DSc theses as well as the information about organized schools and exhibitions. The second one: ``Reports on Research`` describes the research activities of SINS. It is divided into 12 parts - in which the works of SINS departments and establishments are presented (Department of Nuclear Reactions, Department of Nuclear Spectroscopy and Technique, Department of Nuclear Electronics, Department of Radiation Shielding and Dosimetry, Department of Plasma Physics and Technology, Department of High Energy Physics, Department of Cosmic Radiation Physics, Department of Nuclear Theory, Department of Radiation Detectors, Department of Accelerator Physics and Technology, Department of Training an Consulting and Establishment for Nuclear Equipment). Each of these parts are preceded by a short overview given by the head of the given department. The foreword, in which the whole activities of the SINS are summarized, given by head of the Institute professor Z. Sujkowski is also given

  5. Krzysztof Wodiczko’s community art. Analyzing “Poznan Projection”

    Directory of Open Access Journals (Sweden)

    Piotr Juskowiak

    2010-01-01

    Full Text Available The article concentrates on the community issues in Krzysztof Wodiczko’s art. It analyzes one of his latest projects, “Poznan Projection” (the effect of artist’s cooperation with homeless people from “Social Emergency”, in reference to selected philosophical community theories, signed by Jacques Rancière, Jean-Luc Nancy, Julia Kristeva or Jacques Derrida. Author argues that communal character of Wodiczko’s latest works is a consequence of changes in his artistic attitude, passage “from the symbolic and critical politics to the ethical and therapeutic political” (Andrzej Turowski.The text consists of three parts. The first part briefly presents community art as a specific field of public art. The focus is on the ethical dilemmas characteristic for this kind of artistic production. Next part is dedicated to Wodiczko’s vision of community and its articulation in “Poznan Projection”. In the last part of the article, “Poznan Projection” is being confronted with Rancière’s concept of “distribution of the sensible” and Victor Turner’s theory of communitas. Author argues that while most of Wodiczko’s works can be read as political articulation of equality (therefore foundation for a new distribution of the sensible, “Poznan Projection” failed to establish a valid relationship between the “little” community of the homeless and the “big” urban collective.  

  6. Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

    Directory of Open Access Journals (Sweden)

    Vardhman K Rakyan

    2011-09-01

    Full Text Available Monozygotic (MZ twin pair discordance for childhood-onset Type 1 Diabetes (T1D is ∼50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant progress has been made in elucidating the genetics of T1D in recent years, the non-genetic component has remained poorly defined. We hypothesized that epigenetic variation could underlie some of the non-genetic component of T1D aetiology and, thus, performed an epigenome-wide association study (EWAS for this disease. We generated genome-wide DNA methylation profiles of purified CD14+ monocytes (an immune effector cell type relevant to T1D pathogenesis from 15 T1D-discordant MZ twin pairs. This identified 132 different CpG sites at which the direction of the intra-MZ pair DNA methylation difference significantly correlated with the diabetic state, i.e. T1D-associated methylation variable positions (T1D-MVPs. We confirmed these T1D-MVPs display statistically significant intra-MZ pair DNA methylation differences in the expected direction in an independent set of T1D-discordant MZ pairs (P = 0.035. Then, to establish the temporal origins of the T1D-MVPs, we generated two further genome-wide datasets and established that, when compared with controls, T1D-MVPs are enriched in singletons both before (P = 0.001 and at (P = 0.015 disease diagnosis, and also in singletons positive for diabetes-associated autoantibodies but disease-free even after 12 years follow-up (P = 0.0023. Combined, these results suggest that T1D-MVPs arise very early in the etiological process that leads to overt T1D. Our EWAS of T1D represents an important contribution toward understanding the etiological role of epigenetic variation in type 1 diabetes, and it is also the first systematic analysis of the temporal origins of disease-associated epigenetic variation for any human complex disease.

  7. Recent developments on the role of epigenetics in obesity and metabolic disease.

    Science.gov (United States)

    van Dijk, Susan J; Tellam, Ross L; Morrison, Janna L; Muhlhausler, Beverly S; Molloy, Peter L

    2015-01-01

    The increased prevalence of obesity and related comorbidities is a major public health problem. While genetic factors undoubtedly play a role in determining individual susceptibility to weight gain and obesity, the identified genetic variants only explain part of the variation. This has led to growing interest in understanding the potential role of epigenetics as a mediator of gene-environment interactions underlying the development of obesity and its associated comorbidities. Initial evidence in support of a role of epigenetics in obesity and type 2 diabetes mellitus (T2DM) was mainly provided by animal studies, which reported epigenetic changes in key metabolically important tissues following high-fat feeding and epigenetic differences between lean and obese animals and by human studies which showed epigenetic changes in obesity and T2DM candidate genes in obese/diabetic individuals. More recently, advances in epigenetic methodologies and the reduced cost of epigenome-wide association studies (EWAS) have led to a rapid expansion of studies in human populations. These studies have also reported epigenetic differences between obese/T2DM adults and healthy controls and epigenetic changes in association with nutritional, weight loss, and exercise interventions. There is also increasing evidence from both human and animal studies that the relationship between perinatal nutritional exposures and later risk of obesity and T2DM may be mediated by epigenetic changes in the offspring. The aim of this review is to summarize the most recent developments in this rapidly moving field, with a particular focus on human EWAS and studies investigating the impact of nutritional and lifestyle factors (both pre- and postnatal) on the epigenome and their relationship to metabolic health outcomes. The difficulties in distinguishing consequence from causality in these studies and the critical role of animal models for testing causal relationships and providing insight into underlying

  8. Identification of type 1 diabetes-associated DNA methylation variable positions that precede disease diagnosis.

    Directory of Open Access Journals (Sweden)

    Vardhman K Rakyan

    2011-09-01

    Full Text Available Monozygotic (MZ twin pair discordance for childhood-onset Type 1 Diabetes (T1D is ∼50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease. Although significant progress has been made in elucidating the genetics of T1D in recent years, the non-genetic component has remained poorly defined. We hypothesized that epigenetic variation could underlie some of the non-genetic component of T1D aetiology and, thus, performed an epigenome-wide association study (EWAS for this disease. We generated genome-wide DNA methylation profiles of purified CD14+ monocytes (an immune effector cell type relevant to T1D pathogenesis from 15 T1D-discordant MZ twin pairs. This identified 132 different CpG sites at which the direction of the intra-MZ pair DNA methylation difference significantly correlated with the diabetic state, i.e. T1D-associated methylation variable positions (T1D-MVPs. We confirmed these T1D-MVPs display statistically significant intra-MZ pair DNA methylation differences in the expected direction in an independent set of T1D-discordant MZ pairs (P = 0.035. Then, to establish the temporal origins of the T1D-MVPs, we generated two further genome-wide datasets and established that, when compared with controls, T1D-MVPs are enriched in singletons both before (P = 0.001 and at (P = 0.015 disease diagnosis, and also in singletons positive for diabetes-associated autoantibodies but disease-free even after 12 years follow-up (P = 0.0023. Combined, these results suggest that T1D-MVPs arise very early in the etiological process that leads to overt T1D. Our EWAS of T1D represents an important contribution toward understanding the etiological role of epigenetic variation in type 1 diabetes, and it is also the first systematic analysis of the temporal origins of disease-associated epigenetic variation for any human complex disease.

  9. The Role of Field Classes in Education of Prospective Teachers in Biology

    Directory of Open Access Journals (Sweden)

    E. Fleszar

    2009-12-01

    Full Text Available Field classes are indispensable in education of biology and environment protection students, as they allow a future teacher to carry out teaching material bringing together theory and practice through activity. In the framework of Biology Didactics classes the biology students of the Faculty of Natural Sciences at the University of Szczecin participate actively in the works on didactic nature trail in the Arkoñski Woods prepared by Dr. Ewa Fleszar. During the work on didactic natural path the students make themselves acquainted with: field class objectives; field class tasks; field class programmes, e.g. concerning phenology; flora and fauna species. Writing synopsis of field classes for selected lesson units at different teaching levels they acquire sound knowledge based on the ecological contents. Contacts with nature as well as gaining the experience during field classes allow them to obtain competences for working in the field and to understand the objectives of carrying out such classes. Field classes have an effect on developing interests of participants in the subject, and affect the improvement of teaching performance. Visit to the field forms ecological awareness, which leads to obtaining an ecological culture.

  10. The political economy of coal subsidies in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, K. [University of Adelaide, Adelaide, SA (Australia). Dept. of Economics and Centre for International Economic Studies

    1995-06-01

    Both the mining and the burning of coal is polluting, so we might expect to observe taxes on coal production and consumption. Yet several countries of Western Europe subsidize coal production, and most East European countries subsidize coal consumption. The first part of this paper shows that those subsidies, which are emulated by other rich and poor countries respectively, have become enormous. Neoclassical political economy is used to examine why governments adopt such inappropriate policies when they are so wasteful of resources and damaging to the environment. Several new and offsetting political forces have been at work in Western Europe in recent years though, causing some countries to dismantle their coal producer subsidies. The paper concludes that these pressures for reform will continue to operate in the new remaining protectionist countries; if coupled with more commercial diplomatic pressure from coal exporting countries, they could be sufficient to see the end of such protection by early next century. A comment by Ewa Rabinowicz follows this article on pages 497-498. 26 refs., 1 fig., 11 tabs.

  11. HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT.

    Science.gov (United States)

    Wang, Shuo; Song, Jieyun; Yang, Yide; Zhang, Yining; Wang, Haijun; Ma, Jun

    2015-01-01

    Gene polymorphisms associated so far with body mass index (BMI) can explain only 1.18-1.45% of observed variation in BMI. Recent studies suggest that epigenetic modifications, especially DNA methylation, could contribute to explain part of the missing heritability, and two epigenetic genome-wide analysis studies (EWAS) have reported that Hypoxia Inducible Factor 3 Alpha Subunit (HIF3A) methylation was associated with BMI or BMI change. We therefore assessed whether the HIF3A methylation is associated with obesity and other obesity-related phenotypes in Chinese children. The subjects included 110 severe obese cases aged 7-17y and 110 normal-weight controls matched by age and gender for measurement of blood DNA methylation levels at the HIF3A gene locus using the Sequenom's MassARRAY system. We observed significantly higher methylation levels in obese children than in controls at positions 46801642 and 46801699 in HIF3A gene (Pobesity, and has a BMI-independent association with ALT. The results provide evidence for identifying epigenetic factors of elivated ALT and may be useful for risk assessment and personalized medicine of liver diseases such as non-alcoholic fatty liver disease (NAFLD).

  12. HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT.

    Directory of Open Access Journals (Sweden)

    Shuo Wang

    Full Text Available Gene polymorphisms associated so far with body mass index (BMI can explain only 1.18-1.45% of observed variation in BMI. Recent studies suggest that epigenetic modifications, especially DNA methylation, could contribute to explain part of the missing heritability, and two epigenetic genome-wide analysis studies (EWAS have reported that Hypoxia Inducible Factor 3 Alpha Subunit (HIF3A methylation was associated with BMI or BMI change. We therefore assessed whether the HIF3A methylation is associated with obesity and other obesity-related phenotypes in Chinese children. The subjects included 110 severe obese cases aged 7-17y and 110 normal-weight controls matched by age and gender for measurement of blood DNA methylation levels at the HIF3A gene locus using the Sequenom's MassARRAY system. We observed significantly higher methylation levels in obese children than in controls at positions 46801642 and 46801699 in HIF3A gene (P<0.05, and found positive associations between methylation and alanine aminotransferase (ALT levels adjusted by gender, age and BMI at the position 46801699 (r = 0.226, P = 0.007. These results suggest that HIF3A DNA methylation is associated with childhood obesity, and has a BMI-independent association with ALT. The results provide evidence for identifying epigenetic factors of elivated ALT and may be useful for risk assessment and personalized medicine of liver diseases such as non-alcoholic fatty liver disease (NAFLD.

  13. Nobel prize-winner Heinrich Rohrer visits CERN

    CERN Multimedia

    2008-01-01

    The Nobel prize-winner Heinrich Rohrer met young scientists on a recent visit to the Laboratory. From left to right: Xavier Gréhant (CERN Openlab), Ewa Stanecka (ATLAS), Magda Kowalska (ISOLDE), Heinrich Rohrer, Stéphanie Beauceron (CMS) and Ana Gago Da Silva (UNOSAT).Heinrich Rohrer, who shared the 1986 Nobel prize for physics with Gerd Binnig for the design of the scanning tunnelling microscope, visited CERN on 25 June. Welcomed by the Director-General, Robert Aymar, he visited the ATLAS cavern and control room, the Computer Centre, the Unosat project, the Antimatter Decelerator and ISOLDE. At the end of his visit, he voiced his admiration for CERN and its personnel. As a renowned Nobel prize-winner Heinrich Rohrer has the opportunity to pass on his experience and enthusiasm to young scientists. During the evening meal, at which he met five young physicists and computer scientists, who were delighted with the chance to talk to him, he stressed the importance for re...

  14. Aspectos de complexidade do trabalho de coletores de lixo domiciliar: a gestão da variabilidade do trabalho na rua Aspects of the complexity of domestic waste collection: management of street work variability

    Directory of Open Access Journals (Sweden)

    Renata Campos Vasconcelos

    2008-08-01

    Full Text Available O termo complexidade é bastante utilizado em pesquisas ergonômicas. Entretanto, raramente se fala da complexidade de atividades consideradas "manuais" ou "braçais". O objetivo deste artigo foi demonstrar que existe uma complexidade inerente aos trabalhos considerados predominantemente "físicos", como no caso dos garis que realizam a coleta de lixo domiciliar, e que esta complexidade exige uma constante gestão por parte dos trabalhadores. O artigo também apresenta aspectos que classificam um trabalho como complexo. Utilizando a metodologia da Análise Ergonômica do Trabalho, mostramos como os garis gerenciam a variabilidade de seu trabalho, demonstrando que a complexidade de seu trabalho é comparável a outros tipos de atividades consideradas como complexas.The term complexity is frequently used in ergonomics research. However, the complexity of manual labor is rarely addressed. This article aims to demonstrate that there is a level of complexity involved in work considered predominantly physical, such as that of domestic waste collection, and that this complexity requires constant management on the part of workers. Aspects classifying a type of work as complex are also presented. Using the method of Ergonomic Work Analysis (EWA, we show how waste collectors manage the variability of their activities, demonstrating that the complexity of their work is comparable to that of other activities considered complex.

  15. Entropy-Weighted Instance Matching Between Different Sourcing Points of Interest

    Directory of Open Access Journals (Sweden)

    Lin Li

    2016-01-01

    Full Text Available The crucial problem for integrating geospatial data is finding the corresponding objects (the counterpart from different sources. Most current studies focus on object matching with individual attributes such as spatial, name, or other attributes, which avoids the difficulty of integrating those attributes, but at the cost of an ineffective matching. In this study, we propose an approach for matching instances by integrating heterogeneous attributes with the allocation of suitable attribute weights via information entropy. First, a normalized similarity formula is developed, which can simplify the calculation of spatial attribute similarity. Second, sound-based and word segmentation-based methods are adopted to eliminate the semantic ambiguity when there is a lack of a normative coding standard in geospatial data to express the name attribute. Third, category mapping is established to address the heterogeneity among different classifications. Finally, to address the non-linear characteristic of attribute similarity, the weights of the attributes are calculated by the entropy of the attributes. Experiments demonstrate that the Entropy-Weighted Approach (EWA has good performance both in terms of precision and recall for instance matching from different data sets.

  16. Predicting NCLEX-RN Success: the Seventh Validity Study HESI Exit exam.

    Science.gov (United States)

    Young, Anne; Willson, Pamela

    2012-01-01

    The findings of six previously conducted studies indicated that the HESI (E) was highly accurate in predicting NCLEX-RN success. The purpose of this study-the seventh study to investigate the validity of the E-was to examine the accuracy of three parallel versions of the Ein predicting licensure success and to describe program practices regarding E benchmark scores, remediation programs, and retesting policies. The findings of this study again indicated that the E was highly accurate in predicting NCLEX-RN success. Additionally, all three versions of the E were found to have a predictive accuracy above 90%. The most common E benchmark score designated by faculty at the participating schools was 850, and most schools required students to retest with different versions of the E until the faculty-designated E benchmark score was achieved. Remediation seemed to be effective in raising students' E scores, and it was recommended that future research investigate the effectiveness of specific remediation strategies.

  17. Surface scattering and giant magnetoresistance: In-situ resistance and magnetoresistance experiments

    Science.gov (United States)

    Bailey, William Evans

    Surface scattering, particularly the enhancement of "specular" scattering, is widely believed to hold the key to yet-unattained levels of spin-valve GMR. We have developed a novel technique to measure surface scattering, the in-situ magnetoconductance measurement. By measuring resistance and GMR in real time during deposition, in ultrahigh vacuum, and in the Van der Pauw configuration, we may determine the effect on scattering of various overlayers as they are created. We have applied this technique to study claims that the specularity may be modified through deposition of metal overlayers. In conjunction with first-principles based calculations of film conductance and detailed characterization of thickness-dependent film microstructure, we have determined that the surface specularity is not modified during overlayer deposition. Effects previously attributed to specularity modulations are well interpreted through scattering mechanisms intrinsic to the system. We have also examined the dependence of GMR on bulk microstructure, as characterized ex-situ. We find that crystallographic disorder tends to decrease spin-valve GMR. This is shown experimentally through depositions of several series of samples, characterization of the relevant defects, and correlation to magnetotransport measurements. We have formed the films by sputtering and UHV ion beam deposition. Experimental techniques used to characterize microstructure are high-resolution cross-sectional transmission electron microscopy (HR-xTEM), x-ray diffraction (XRD), 59Co nuclear magnetic resonance (NMR), contributed by Ewa Jedryka at the Polish Institute of Physics in Warsaw.

  18. Immunogold-silver staining (IGSS) based U-bent fiberoptic sandwich biosensor

    Science.gov (United States)

    Ramakrishna, B.; Sai, V. V. R.

    2016-11-01

    An evanescent wave absorbance (EWA) based U-bent fiberoptic sandwich immunobiosensor with human IgG detection limits of 6.67 fM (1 pg/ml of human IgG) and 66.7 aM (10 fg/ml of HIgG) is demonstrated by exploiting immunogold labels and subsequently silver enhancement respectively. Such very low detection limits were achieved with the help of enhanced evanescent filed at the bend region of U-bent optical fiber probe that allows efficient interaction of light with 40 nm immunogold labels on the probe surface resulting in measurable optical absorbance changes. The other significant advantages of the demonstrated sensing scheme are low cost optoelectronic instrumentation consisting of an commercial green LED and a photodetector (S150C, Thorlabs Inc.), small volumes of sample and immunogold reagent each of 25 μl and rapid detection in 20 min. These results from the plasmonic fiberoptic biosensor demonstrate its huge potential for development of point-of-care diagnostic devices for sensitive and rapid detection of analytes.

  19. Ergonomics and risk management in high risk organizations: nuclear power plant operator decision making; A ergonomia e a gestao de risco em organizacoes que lidam com tecnologias perigosas: tomada de decisao de operadores de usinas nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Paulo Victor Rodrigues de

    2003-08-15

    Nuclear power plants are high hazard environments where emergency situations can have devastating effects. The operator crew has the ultimate responsibility to control the energy production process with safety. The outcome of a crisis is consequently dependent on the crew's judgement, decision making and situation awareness. In such way we should know how operators make their decisions in order to develop safety strategies. The aim of this thesis is to examine the cognitive processes through which operators make decisions when dealing with micro incidents during their actual work, and to determine whether they use a naturalistic or normative decision making strategy. That is, do they try to recognize the micro incident as familiar and base decisions on condition-action rules (naturalistic), or do they need to concurrently compare and contrast options before selecting the best possible (normative). The method employed for data collection was the Cognitive Task Analysis (CTA) and Ergonomic Work Analysis (EWA). The main findings of this thesis were that decision making is primarily based on naturalistic strategies, such as condition-action rules and recognition. In new situations rules are created ad hoc. These rules appear derived from experience and training rather than from Standard Operating Procedures and contrast normative competence standards used by nuclear industry. (author)

  20. PREFACE: MicroTherm' 2013 - Microtechnology and Thermal Problems in Electronics

    Science.gov (United States)

    Lisik, Zbigniew; Raj, Ewa

    2014-04-01

    MicroTherm is an International Conference on Microtechnology and Thermal Problems in Electronics organised as a cyclic event since 1996. The success of the first seminar, which was devoted mainly to thermal management aspects, and the successive conferences have led us to the tenth edition. Since the first meeting, the scope of the conference has expanded, following the progress of electronics. Now, it covers subjects connected with extreme temperature, electronics, sensors and measurement techniques, modelling, simulation, wide band-gap materials, packaging and reliability, renewable energy sources and photonics with special emphasis on microelectronic technologies. MicroTherm' 2013 was held in Lodz, Poland, on 25-28 June 2013. The programme consistied of invited talks and nine regular sessions in the form of planar discussions and poster presentations, including a Students' Session. The Students' session gave an opportunity for students and young researchers to present their first achievements in the field of science. The next MicroTherm Conference is going to be held on 22-25 June 2015, in Lodz — a beautiful, post-industrial city located in the centre of Poland. Please, feel invited to MicroTherm' 2015 (www.microtherm.dsod.pl). Ewa Raj and Zbigniew Lisik Editors

  1. How do users design? The case of sugar cane harvester machines.

    Science.gov (United States)

    Narimoto, Lidiane Regina; Camarotto, João Alberto

    2017-01-01

    Design in use and inventiveness are key concepts in ergonomics. It is well-known that users design but is not explored in the literature how they manage to do that. This paper aims to contribute to the discussion of how users actually design, by showing a research conducted in sugar cane harvesting in Brazil and in Australia. Through the methodology of the Ergonomic Work Analysis (EWA), the design modifications made by the harvesting teams were identified as well as their elaboration process. Three categories of modifications in machines' design were identified: structural, functional and operational and they were more numerous in Brazilian situations. It is proposed that two theories underlying the theme are intertwined: the instrument-mediated activity approach and the design as bricolage. It is argued that users design through the articulation of: a) the operators' activity, b) the mechanical technicians' inventory to practice bricolage as a way of designing and c) the work organisation and the existence of social spaces of interaction between these two subjects.

  2. Evanescent wave absorption sensor based on tapered multimode fiber coated with monolayer graphene film

    Science.gov (United States)

    Qiu, Hengwei; Gao, Saisai; Chen, Peixi; Li, Zhen; Liu, Xiaoyun; Zhang, Chao; Xu, Yuanyuan; Jiang, Shouzhen; Yang, Cheng; Huo, Yanyan; Yue, Weiwei

    2016-05-01

    An evanescent wave absorption (EWA) sensor based on tapered multimode fiber (TMMF) coated with monolayer graphene film for the detection of double-stranded DNA (DS-DNA) is investigated in this work. The TMMF is a silica multimode fiber (nominally at 62.5 μm), which was tapered to symmetric taper with waist diameters of ~30 μm and total length of ~3 mm. Monolayer graphene film was grown on a copper foil via chemical vapor deposition (CVD) technology and transferred onto skinless tapered fiber core via dry transfer technology. All the components of the sensor are coupled together by fusion splicer in order to eliminate the external disturbance. DS-DNA is created by the assembly of two relatively complemented oligonucleotides. The measurements are obtained by using a spectrometer in the optical wavelength range of 400-900 nm. With the increase of DS-DNA concentration, the output light intensity (OPLI) arisen an obvious attenuation. Importantly, the absorbance (A) and the DS-DNA concentrations shown a reasonable linear variation in a wide range of 5-400 μM. Through a series of comparison, the accuracy of TMMF sensor with graphene (G-TMMF) is much better than that without graphene (TMMF), which can be attributed to the molecular enrichment of graphene by π-π stacking.

  3. ERGONOMIC WORK ANALYSIS APPLICATION IN A SMALL SHOE BUSINESS

    Directory of Open Access Journals (Sweden)

    Aline Marian Callegaro

    2013-11-01

    Full Text Available This paper aims to presentthe results after conducting an Ergonomic Work Analysis (EWA in a smallbusiness located in Porto Alegre. The ergonomic intervention was performed basedon Guérin et al. (2001 and aimed to analyze the process organization and thelayout of the shoemaker workstations to provide improvements to these areas.The starting point was the account of the small shoe business owner’s need hadto hire one more shoemaker without increasing the company physical space. The EWAwas used focusing the work organization, how the flow of information ran fromthe entry of an order to the final stage of the product repairing. Thediagnosis showed the company main problems were related to the shop assistantsdependence on the shoemakers to provide budget information and delivery time tocustomers and the layout organization. Among the results, a temporal analysisof two company recurrent tasks was performed in order to ascertain possiblelosses related to the displacement and the search for material. A new layoutscheme was also proposed, aiming to organize the work stations, making easierthe stock, tools and equipment removal, providing a free space to make possiblethe hiring of the new shoemakers within the current company boundaries.

  4. Ergonomic activity analysis of the musicians of the Symphony Orchestra of Paraná state: risk factors and workloads

    Directory of Open Access Journals (Sweden)

    Jaqueline de Lima

    2014-04-01

    Full Text Available This study aimed to investigate the risk factors present in the work activity and their impact on the health of the musicians of the Symphony Orchestra of Parana state. It is a descriptive qualitative research based on the method of Ergonomic Workplace Analysis of Francophone strand, used as a tool by occupational therapists in the health-work interface. The following procedures were performed: bibliographical survey, documental analysis of productivity data, production and quality of the task, systematic observation of the rehearsals of the Symphony Orchestra of Parana, task and workplace analysis with the application of Ergonomic Workplace Analysis (EWA and, confrontation of the data analyzed with an instrumental musician. As a result, the study showed significant deviations with reference to the standards described in Brazilian Norm 17 (Ergonomics, especially regarding individual cognitive and physical demands as well as demands related to work organization, considering each item evaluated by this analytical instrument. The action of occupational therapy was grounded on the insertion in the health and illness process, health promotion, illness prevention, and training of musicians as workers and social actors, envisioning the transformation of work situations.

  5. Epigenome-Wide Association Study of Tic Disorders.

    Science.gov (United States)

    Zilhão, Nuno R; Padmanabhuni, Shanmukha S; Pagliaroli, Luca; Barta, Csaba; Smit, Dirk J A; Cath, Danielle; Nivard, Michel G; Baselmans, Bart M L; van Dongen, Jenny; Paschou, Peristera; Boomsma, Dorret I

    2015-12-01

    Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p tic disorders. The top significantly enriched gene ontology (GO) terms among higher ranking methylation sites included anatomical structure morphogenesis (GO:0009653, p = 4.6 × 10-(15)) developmental process (GO:0032502, p = 2.96 × 10(-12)), and cellular developmental process (GO:0048869, p = 1.96 × 10(-12)). Overall, these results provide a first insight into the epigenetic mechanisms of tic disorders. This first study assesses the role of DNA methylation in tic disorders, and it lays the foundations for future work aiming to unravel the biological mechanisms underlying the architecture of this disorder.

  6. Materials from seminar session of the 3.general assembly of Polish Nuclear Society; 3.Walny Zjazd Polskiego Towarzystwa Nukleonicznego. Materialy sesji seminaryjnej

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    This publication edited as a scientific report of the Institute of Atomic Energy contains papers presented on the seminar session accompanying the 3rd General Assembly of Polish Nuclear Society. Five of these are dealing with the present situation in Poland in the framework of the following subjects: foreseeing electricity demand as a significant factor of development of electricity generation sector and nuclear option choice; present state and development trends of nuclear technique applications in industry, agriculture, health and environment protection; radioactive waste management especially related to the storage of spent fuel from EWA and MARIA research reactors; present educational problems in nuclear science and technology. The problems of nuclear power could not be excluded from the session, although it does not exist in Poland and no plans foresee it currently. The paper on nuclear power contains an extensive summary of nuclear power development worldwide, its safety problems, economic competitiveness and public acceptance. The so called ``Sellafield phenomenon`` considering the growth of leukaemia deaths of children living near that reprocessing plant in England has been commented in mass media criticizing nuclear energy application. The paper on this problem present the results of investigations and hypotheses on reasons having caused this phenomenon. The declaration of the International Council of Nuclear Societies on the role of nuclear science and technology in supporting the development is also included in the report.

  7. DNA Modifications and Alzheimer's Disease.

    Science.gov (United States)

    Smith, Rebecca G; Lunnon, Katie

    2017-01-01

    Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting millions of people worldwide. While a number of studies have focused on identifying genetic variants that contribute to the development and progression of late-onset AD, the majority of these only have a relatively small effect size. There are also a number of other risk factors, for example, age, gender, and other comorbidities; however, how these influence disease risk is not known. Therefore, in recent years, research has begun to investigate epigenetic mechanisms for a potential role in disease etiology. In this chapter, we discuss the current state of play for research into DNA modifications in AD, the most well studied being 5-methylcytosine (5-mC). We describe the earlier studies of candidate genes and global measures of DNA modifications in human AD samples, in addition to studies in mouse models of AD. We focus on recent epigenome-wide association studies (EWAS) in human AD, using microarray technology, examining a number of key study design issues pertinent to such studies. Finally, we discuss how new technological advances could further progress the research field.

  8. Across-Platform Imputation of DNA Methylation Levels Incorporating Nonlocal Information Using Penalized Functional Regression.

    Science.gov (United States)

    Zhang, Guosheng; Huang, Kuan-Chieh; Xu, Zheng; Tzeng, Jung-Ying; Conneely, Karen N; Guan, Weihua; Kang, Jian; Li, Yun

    2016-05-01

    DNA methylation is a key epigenetic mark involved in both normal development and disease progression. Recent advances in high-throughput technologies have enabled genome-wide profiling of DNA methylation. However, DNA methylation profiling often employs different designs and platforms with varying resolution, which hinders joint analysis of methylation data from multiple platforms. In this study, we propose a penalized functional regression model to impute missing methylation data. By incorporating functional predictors, our model utilizes information from nonlocal probes to improve imputation quality. Here, we compared the performance of our functional model to linear regression and the best single probe surrogate in real data and via simulations. Specifically, we applied different imputation approaches to an acute myeloid leukemia dataset consisting of 194 samples and our method showed higher imputation accuracy, manifested, for example, by a 94% relative increase in information content and up to 86% more CpG sites passing post-imputation filtering. Our simulated association study further demonstrated that our method substantially improves the statistical power to identify trait-associated methylation loci. These findings indicate that the penalized functional regression model is a convenient and valuable imputation tool for methylation data, and it can boost statistical power in downstream epigenome-wide association study (EWAS).

  9. Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA.

    Science.gov (United States)

    Wong, Nicholas C; Ng, Jane; Hall, Nathan E; Lunke, Sebastian; Salmanidis, Marika; Brumatti, Gabriela; Ekert, Paul G; Craig, Jeffrey M; Saffery, Richard

    2013-07-01

    Illumina Infinium Human Methylation (HM) BeadChips are widely used for measuring genome-scale DNA methylation, particularly in relation to epigenome-wide association studies (EWAS) studies. The methylation profile of human samples can be assessed accurately and reproducibly using the HM27 BeadChip (27,578 CpG sites) or its successor, the HM450 BeadChip (482,421 CpG sites). To date no mouse equivalent has been developed, greatly hindering the application of this methodology to the wide range of valuable murine models of disease and development currently in existence. We found 1308 and 13,715 probes from HM27 and HM450 BeadChip respectively, uniquely matched the bisulfite converted reference mouse genome (mm9). We demonstrate reproducible measurements of DNA methylation at these probes in a range of mouse tissue samples and in a murine cell line model of acute myeloid leukaemia. In the absence of a mouse counterpart, the Infinium Human Methylation BeadChip arrays have utility for methylation profiling in non-human species.

  10. Learning in Networks—An Experimental Study Using Stationary Concepts

    Directory of Open Access Journals (Sweden)

    Siegfried K. Berninghaus

    2014-07-01

    Full Text Available Our study analyzes theories of learning for strategic interactions in networks. Participants played two of the 2 × 2 games used by Selten and Chmura [1]. Every participant played against four neighbors. As a distinct aspect our experimental design allows players to choose different strategies against each different neighbor. The games were played in two network structures: a lattice and a circle. We analyze our results with respect to three aspects. We first compare our results with the predictions of five different equilibrium concepts (Nash equilibrium, quantal response equilibrium, action-sampling equilibrium, payoff-sampling equilibrium, and impulse balance equilibrium which represent the long-run equilibrium of a learning process. Secondly, we relate our results to four different learning models (impulse-matching learning, action-sampling learning, self-tuning EWA, and reinforcement learning which are based on the (behavioral round-by-round learning process. At last, we compare the data with the experimental results of Selten and Chmura [1]. One main result is that the majority of players choose the same strategy against each neighbor. As other results, we observe an order of predictive success for the equilibrium concepts that is different from the order shown by Selten and Chmura and an order of predictive success for the learning models that is only slightly different from the order shown in a recent paper by Chmura, Goerg and Selten [2].

  11. Committees and organizers

    Science.gov (United States)

    2011-07-01

    Chairman:Jozef Spałek (Kraków) Program Committee:Stephen Blundell (Oxford), J Michael D Coey (Dublin), Dominique Givord (Grenoble), Dariusz Kaczorowski (Wrocław), Roman Micnas (Poznań), Marek Przybylski (Halle), Ludiwig Schultz (Dresden), Vladimir Sechovsky (Prague), Jozef Spałek (Kraków), Henryk Szymczak (Warszawa), Manuel Vázquez (Madrid) Publication Committee:Dariusz Kaczorowski, Robert Podsiadły, Jozef Spałek, Henryk Szymczak, Andrzej Szytuła Local committee:Maria Bałanda, Anna Majcher, Robert Podsiadły, Michał Rams, Andrzej Ślebarski, Krzysztof Tomala Editors of the Proceedings:Jozef Spałek, Krzysztof Tomala, Danuta Goc-Jagło, Robert Podsiadły, Michał Rams, Anna Majcher Plenary, semi-plenary and tutorial speakers:Ernst Bauer (Wien)Stephen Blundell (Oxford)J Michael D Coey (Dublin)Russell P Cowburn (London)Burkard Hillebrands (Kaiserslautern)Claudine Lacroix (Grenoble)Lluís Mañosa (Barcelona)María del Carmen Muñoz (Madrid)Bernard Raveau (Caen)Pedro Schlottmann (Tallahassee)Frank Steglich (Dresden)Oliver Waldmann (Freiburg) Invited speakers within symposia: R Ahuja (Uppsala)A Kirilyuk (Nijmegen) M Albrecht (Vienna)L Theil Kuhn (Roskilde) K Bärner (Göttingen)J Liu (Dresden) U Bovensiepen (Duisburg)G Lorusso (Modena) V Buchelnikov (Chelyabinsk)M M Maska (Katowice) B Chevalier (Bordeaux)Y Mukovskii (Moscow) O Chubykalo-Fesenko (Madrid)M Pannetier-Lecoeur (Saclay) A V Chumak (Kaiserslautern)G Papavassiliou (Athens) J M D Coey (Dublin)K R Pirota (Campinas) B Dabrowski (DeKalb)P Przyslupski (Warszawa) S Das (Aveiro)M Reiffers (Košice) A del Moral (Zaragoza)K Sandeman (London) V E Demidov (Muenster)D Sander (Halle) B Djafari-Rouhani (Lille)M Sawicki (Sendai/Warsaw) H A Dürr (Menlo Park)J Schaefer (Würzburg) J Fassbender (Dresden)H Schmidt (Wetzikon) J Fontcuberta (Barcelona)J Spałek (Kraków) V Garcia (Orsay)L Straka (Helsinki) J N Gonçalves (Aveiro)A Szewczyk (Warszawa) M E Gruner (Duisburg)Y Taguchi (Wako) G Gubbiotti (Perugia)A Thiaville

  12. Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol

    Directory of Open Access Journals (Sweden)

    Donejko M

    2017-03-01

    Full Text Available Magdalena Donejko,1 Edyta Rysiak,2 Elżbieta Galicka,1 Robert Terlikowski,3 Edyta Katarzyna Głażewska,1 Andrzej Przylipiak1 1Department of Esthetic Medicine, 2Department of Medicinal Chemistry, Faculty of Pharmacy, 3Department of Health Restoration, Medical University of Białystok, Białystok, Poland Aim: The aim of this study was to evaluate the effect of ethanol and hyaluronic acid (HA on cell survival and apoptosis in cultured human skin fibroblasts. Regarding the mechanism of ethanol action on human skin fibroblasts, we investigated cell viability and apoptosis, expression of focal adhesion kinase (FAK, and the influence of HA on those processes. Materials and methods: Studies were conducted in confluent human skin fibroblast cultures that were treated with 25 mM, 50 mM, and 100 mM ethanol or with ethanol and 500 µg/mL HA. Cell viability was examined using methyl thiazolyl tetrazolium (MTT assay and NC-300 Nucleo-Counter. Imaging of the cells using a fluorescence microscope Pathway 855 was performed to measure FAK expression. Results: Depending on the dosage, ethanol decreased cell viability and activated the process of apoptosis in human skin fibroblasts. HA prevented the negative influence of ethanol on cell viability and prevented apoptosis. The analysis of fluorescence imaging using BD Pathway 855 High-Content Bioimager showed the inhibition of FAK migration to the cell nucleus, depending on the increasing concentration of ethanol. Conclusion: This study proves that downregulation of signaling pathway of FAK is involved in ethanol-induced apoptosis in human skin fibroblasts. The work also indicates a protective influence of HA on FAK activity in human skin fibroblasts exposed to ethanol. Keywords: apoptosis, skin fibroblast, focal adhesion kinase, hyaluronic acid, ethanol

  13. 2K09 and thereafter : the coming era of integrative bioinformatics, systems biology and intelligent computing for functional genomics and personalized medicine research.

    Science.gov (United States)

    Yang, Jack Y; Niemierko, Andrzej; Bajcsy, Ruzena; Xu, Dong; Athey, Brian D; Zhang, Aidong; Ersoy, Okan K; Li, Guo-Zheng; Borodovsky, Mark; Zhang, Joe C; Arabnia, Hamid R; Deng, Youping; Dunker, A Keith; Liu, Yunlong; Ghafoor, Arif

    2010-12-01

    Significant interest exists in establishing synergistic research in bioinformatics, systems biology and intelligent computing. Supported by the United States National Science Foundation (NSF), International Society of Intelligent Biological Medicine (http://www.ISIBM.org), International Journal of Computational Biology and Drug Design (IJCBDD) and International Journal of Functional Informatics and Personalized Medicine, the ISIBM International Joint Conferences on Bioinformatics, Systems Biology and Intelligent Computing (ISIBM IJCBS 2009) attracted more than 300 papers and 400 researchers and medical doctors world-wide. It was the only inter/multidisciplinary conference aimed to promote synergistic research and education in bioinformatics, systems biology and intelligent computing. The conference committee was very grateful for the valuable advice and suggestions from honorary chairs, steering committee members and scientific leaders including Dr. Michael S. Waterman (USC, Member of United States National Academy of Sciences), Dr. Chih-Ming Ho (UCLA, Member of United States National Academy of Engineering and Academician of Academia Sinica), Dr. Wing H. Wong (Stanford, Member of United States National Academy of Sciences), Dr. Ruzena Bajcsy (UC Berkeley, Member of United States National Academy of Engineering and Member of United States Institute of Medicine of the National Academies), Dr. Mary Qu Yang (United States National Institutes of Health and Oak Ridge, DOE), Dr. Andrzej Niemierko (Harvard), Dr. A. Keith Dunker (Indiana), Dr. Brian D. Athey (Michigan), Dr. Weida Tong (FDA, United States Department of Health and Human Services), Dr. Cathy H. Wu (Georgetown), Dr. Dong Xu (Missouri), Drs. Arif Ghafoor and Okan K Ersoy (Purdue), Dr. Mark Borodovsky (Georgia Tech, President of ISIBM), Dr. Hamid R. Arabnia (UGA, Vice-President of ISIBM), and other scientific leaders. The committee presented the 2009 ISIBM Outstanding Achievement Awards to Dr. Joydeep Ghosh (UT

  14. Effect of combinations of antiviral drugs on herpes simplex encephalitis

    Directory of Open Access Journals (Sweden)

    Bryan M Gebhardt

    2009-12-01

    Full Text Available Bryan M Gebhardt1, Federico Focher2, Richard Eberle3, Andrzej Manikowski4, George E Wright41LSU Eye Center, Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, LA, USA; 2Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy; 3Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, USA; 4GLSynthesis Inc., Worcester, MA, USAAbstract: 2-Phenylamino-6-oxo-9-(4-hydroxybutylpurine (HBPG is a thymidine kinase inhibitor that prevents encephalitic death in mice caused by herpes simplex virus (HSV types 1 and 2, although its potency is somewhat less than that of acyclovir (ACV. The present study was undertaken to determine the effect of combinations of HBPG and either ACV, phosphonoformate (PFA, or cidofovir (CDF against HSV encephalitis. BALB/c mice were given ocular infections with HSV-1 or HSV-2, and treated twice daily intraperitoneally for five days with HBPG, alone or in combination with ACV, PFA, or CDF. Animals were observed daily for up to 30 days, and the day of death of each was recorded. All of the combinations showed additivity, and the combination of HBPG + ACV appeared to be synergistic, ie, protected more mice against HSV-1 encephalitis compared with each drug given alone. Delay of treatment with HBPG for up to two days was still effective in preventing HSV-2 encephalitis. The combination of the thymidine kinase inhibitor HBPG and the antiherpes drug ACV may have synergistic activity against HSV encephalitis. The development of a potent and safe combination therapy for the prevention and/or treatment of HSV infection of the central nervous system can improve the outcome of this infection in humans.Keywords: antivirals, herpetic encephalitis

  15. 2K09 and thereafter : the coming era of integrative bioinformatics, systems biology and intelligent computing for functional genomics and personalized medicine research

    Science.gov (United States)

    2010-01-01

    Significant interest exists in establishing synergistic research in bioinformatics, systems biology and intelligent computing. Supported by the United States National Science Foundation (NSF), International Society of Intelligent Biological Medicine (http://www.ISIBM.org), International Journal of Computational Biology and Drug Design (IJCBDD) and International Journal of Functional Informatics and Personalized Medicine, the ISIBM International Joint Conferences on Bioinformatics, Systems Biology and Intelligent Computing (ISIBM IJCBS 2009) attracted more than 300 papers and 400 researchers and medical doctors world-wide. It was the only inter/multidisciplinary conference aimed to promote synergistic research and education in bioinformatics, systems biology and intelligent computing. The conference committee was very grateful for the valuable advice and suggestions from honorary chairs, steering committee members and scientific leaders including Dr. Michael S. Waterman (USC, Member of United States National Academy of Sciences), Dr. Chih-Ming Ho (UCLA, Member of United States National Academy of Engineering and Academician of Academia Sinica), Dr. Wing H. Wong (Stanford, Member of United States National Academy of Sciences), Dr. Ruzena Bajcsy (UC Berkeley, Member of United States National Academy of Engineering and Member of United States Institute of Medicine of the National Academies), Dr. Mary Qu Yang (United States National Institutes of Health and Oak Ridge, DOE), Dr. Andrzej Niemierko (Harvard), Dr. A. Keith Dunker (Indiana), Dr. Brian D. Athey (Michigan), Dr. Weida Tong (FDA, United States Department of Health and Human Services), Dr. Cathy H. Wu (Georgetown), Dr. Dong Xu (Missouri), Drs. Arif Ghafoor and Okan K Ersoy (Purdue), Dr. Mark Borodovsky (Georgia Tech, President of ISIBM), Dr. Hamid R. Arabnia (UGA, Vice-President of ISIBM), and other scientific leaders. The committee presented the 2009 ISIBM Outstanding Achievement Awards to Dr. Joydeep Ghosh (UT

  16. Odzyskać liberalizm. Recenzja książki Andrzeja Walickiego "Od projektu komunistycznego do neoliberalnej utopii", Warszawa: Universitas 2013

    Directory of Open Access Journals (Sweden)

    Małgorzata Fidelis

    2016-01-01

    Full Text Available To Recover Liberalism. Review of a book by Andrzej Walicki Od projektu komunistycznego do neoliberalnej utopii (From the Communist Project to the Neoliberal Utopia, Warszawa: Universitas 2013 This review discusses a recent book by Andrzej Walicki, Od projektu komunistycznego do neoliberalnej utopii (From the Communist Project to the Neoliberal Utopia (Warszawa: Universitas 2013. The book features a collection of essays, interviews, and scholarly articles published by Walicki in academic and popular journals between 2001 and 2012. Topics include a history of the communist project in a broader European perspective; the significance and legacy of de-Stalinization in Poland, with a particular emphasis on what the author calls "the Polish road away from communism" after 1956; right-wing conservative politics in Poland after 1989, the politicization of the memory of communism; and possible directions for the development of the Polish Left as a necessary component of a healthy democratic system. The compelling scholarly discussion is often combined with autobiographical sketches of an intellectual who has been deeply engaged in intellectual and social life in postwar Poland. Walicki, a prominent intellectual and specialist on intellectual history, studied and worked in Warsaw until he emigrated to Australia and then the United States (The University of Notre Dame in the 1980s. In that sense, Walicki provides a unique perspective on Polish history and culture, influenced by both Polish and American academic worlds and intellectual traditions. The strength of the book is its focus on the role of language and the manipulation of terms such as "communism" or "liberalism" by contemporary political leaders in Poland to achieve specific emotional reactions from the public. One of the central claims of the book is that Polish political elites have "distorted" the meaning of liberalism by connecting it solely to the free market rather than to

  17. Ergonomia e projeto organizacional: a perspectiva do trabalho

    Directory of Open Access Journals (Sweden)

    Francisco de Paula Antunes Lima

    1999-12-01

    Full Text Available Em contraposição à sugestão de somar as abordagens da análise ergonômica do trabalho (AET e do projeto organizacional (PO, apoiada na tese da limitação de seus respectivos objetos, defendemos a tese de que estas disciplinas são concorrentes e disputam um mesmo campo da realidade - o da organização do trabalho como um todo. Em relação aos problemas teóricos e práticos postos pela organização do trabalho, a AET assume uma perspectiva própria no interior da produção (o ponto de vista da atividade - PVA, que consiste em priorizar a interatividade dos sujeitos produtores, situados em qualquer posição da estrutura organizacional, na realização cotidiana de suas tarefas e funções. Sabendo que todo trabalho é socialmente organizado, o PVA constitui uma lógica determinada de coordenação das inter-relações entre os sujeitos sociais enquanto trabalhadores, que elaboram suas próprias normas e quadros de ação e de cooperação. Através da lógica da ativida de é possível construir uma autonomia efetiva dos sujeitos sociais, que reelaboram permanentemente as regras formais dc organização do trabalho, criando uma organização real mais adequada às necessidades da produção concomitantemente com a regulação individual e intcrindividual da carga de trabalho.Instead of joining both ergonomic work analysis (EWA (from the French ergonomics view and organisational design (OD approaches, this paper argues that those disciplines are competing for the same object -the organisation of work (in a wider sense. Regarding both practical and theoretical problems emerged from the organisation of work, EWA developed the activity standpoint (AS. The AS looks for allocate priorities to the interrelations among producers performing their daily tasks. Producers, in turn, can be located at any point of the organisational structure. Accepting that work is socially organised, AS constitute a specific logic to help to co

  18. Corner reflector SAR interferometry as an element of a landslide early warning system

    Science.gov (United States)

    Singer, J.; Riedmann, M.; Lang, O.; Anderssohn, J.; Thuro, K.; Wunderlich, Th.; Heunecke, O.; Minet, Ch.

    2012-04-01

    The development of efficient and cost-effective landslide monitoring techniques is the central aim of the alpEWAS research project (www.alpewas.de). Within the scope of the project a terrestrial geosensor network on a landslide site in the Bavarian Alps has been set up, consisting of low cost GNSS with subcentimeter precision, time domain reflectometry (TDR) and video tacheometry (VTPS). To increase the spatial sampling, 16 low-cost Radar Corner Reflectors (CRs) were installed on the site in 2011. The CRs are to reflect radar signals back to the TerraSAR-X radar satellite, allowing for precise displacement measurements. The subject of this study is the application of the CR SAR Interferometry (CRInSAR) technique, and the integration of the derived motion field into an early warning system for landslide monitoring based on terrestrial measurements. An accurate validation data set is realized independently of the monitoring network using millimeter precision GNSS and tacheometer measurements. The 12 CRs from Astrium Geo-Information Services employed over the test site were specifically designed for TerraSAR-X satellite passes. They are made of concrete with integrated metal plates weighing about 80 to 100 kg. They are of triangular trihedral shape with minimal dimensions to obtain a Radar Cross Section 100 times stronger than that of the surrounding area. The concrete guarantees stability against harsh weather conditions, and robustness with respect to vandalism or theft. In addition, the Technical University of Munich (TUM) and the German Aerospace Center (DLR) installed another four CRs made entirely out of aluminum, with the TUM reflectors being of similar minimum size than the Astrium reflectors. Three CRs were placed on assumed stable ground outside the slope area and shall act as reference reflectors. Since the installation date of most CRs (25/08/2011), TerraSAR-X HighResolution SpotLight data have been repeatedly acquired from ascending orbit over the test

  19. Nanoparticles containing allotropes of carbon have genotoxic effects on glioblastomamultiforme cells

    Directory of Open Access Journals (Sweden)

    Hinzmann M

    2014-05-01

    Full Text Available Mateusz Hinzmann,1 Slawomir Jaworski,1 Marta Kutwin,1 Joanna Jagiello,2 Rafal Kozinski,2 Mateusz Wierzbicki,1 Marta Grodzik,1 Ludwika Lipinska,2 Ewa Sawosz,1 Andrè Chwalibog31Division of Nanobiotechnology, Warsaw University of Life Sciences, 2Institute of Electronic Materials Technology, Warsaw, Poland; 3Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, DenmarkAbstract: The carbon-based nanomaterial family consists of nanoparticles containing allotropes of carbon, which may have a number of interactions with biological systems. The objective of this study was to evaluate the toxicity of nanoparticles comprised of pristine graphene, reduced graphene oxide, graphene oxide, graphite, and ultradispersed detonation diamond in a U87 cell line. The scope of the work consisted of structural analysis of the nanoparticles using transmission electron microscopy, evaluation of cell morphology, and assessment of cell viability by Trypan blue assay and level of DNA fragmentation of U87 cells after 24 hours of incubation with 50 µg/mL carbon nanoparticles. DNA fragmentation was studied using single-cell gel electrophoresis. Incubation with nanoparticles containing the allotropes of carbon did not alter the morphology of the U87 cancer cells. However, incubation with pristine graphene and reduced graphene oxide led to a significant decrease in cell viability, whereas incubation with graphene oxide, graphite, and ultradispersed detonation diamond led to a smaller decrease in cell viability. The results of a comet assay demonstrated that pristine graphene, reduced graphene oxide, graphite, and ultradispersed detonation diamond caused DNA damage and were therefore genotoxic in U87 cells, whereas graphene oxide was not.Keywords: nanostructures, graphene, graphite, diamond, glioblastoma multiforme, geno toxicity

  20. Sense of alexithymia in patients with anxiety disorders comorbid with recurrent urticaria

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    Ogłodek EA

    2016-04-01

    Full Text Available Ewa A Ogłodek,1 Anna M Szota,1 Marek J Just,2 Aleksander Araszkiewicz,1 Adam R Szromek3 1Department of Psychiatry, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Toruń, 2Department of General and Endocrine Surgery, Municipal Hospital, Piekary Śląskie, 3Department of Organization and Management, Silesian University of Technology, Gliwice, Poland Aim: Alexithymia is associated with limited cognitive processing of emotions by an individual suffering from recurrent urticaria and alexithymia and makes them focus on somatic manifestations of emotional arousal and on poorly controlled compulsive reactions to negative stimulation. Alexithymia is considered to be a personality trait, which, along with other factors, predisposes individuals toward developing somatic diseases. The aim of the study was to assess the measurement of alexithymic features in patients with recurrent urticaria and to assess the types of concurrent anxiety disorders and overall anxiety level.Methods: In order to diagnose clinical anxiety symptoms in patients, the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and the Hamilton Anxiety Rating Scale were applied. Alexithymic features were measured by means of a shortened version of the Toronto Alexithymia Scale, characterized by high discrimination power, internal coherence, and reliability.Results: According to the Toronto Alexithymia Scale results, the greatest contributing factor was “inability to differentiate between feelings and bodily sensations”. This was observed in both males and females. Most frequently, the patients were found to suffer from generalized anxiety disorder and social phobia.Conclusion: Alexithymia may result from the difficulty associated with expressing emotions caused by anxiety disorders. Undergoing treatment for anxiety disorders may contribute to reduced exacerbation of urticaria. Keywords: alexithymia, anxiety, recurrent urticaria

  1. U.S. Tsunami Information technology (TIM) Modernization:Developing a Maintainable and Extensible Open Source Earthquake and Tsunami Warning System

    Science.gov (United States)

    Hellman, S. B.; Lisowski, S.; Baker, B.; Hagerty, M.; Lomax, A.; Leifer, J. M.; Thies, D. A.; Schnackenberg, A.; Barrows, J.

    2015-12-01

    Tsunami Information technology Modernization (TIM) is a National Oceanic and Atmospheric Administration (NOAA) project to update and standardize the earthquake and tsunami monitoring systems currently employed at the U.S. Tsunami Warning Centers in Ewa Beach, Hawaii (PTWC) and Palmer, Alaska (NTWC). While this project was funded by NOAA to solve a specific problem, the requirements that the delivered system be both open source and easily maintainable have resulted in the creation of a variety of open source (OS) software packages. The open source software is now complete and this is a presentation of the OS Software that has been funded by NOAA for benefit of the entire seismic community. The design architecture comprises three distinct components: (1) The user interface, (2) The real-time data acquisition and processing system and (3) The scientific algorithm library. The system follows a modular design with loose coupling between components. We now identify the major project constituents. The user interface, CAVE, is written in Java and is compatible with the existing National Weather Service (NWS) open source graphical system AWIPS. The selected real-time seismic acquisition and processing system is open source SeisComp3 (sc3). The seismic library (libseismic) contains numerous custom written and wrapped open source seismic algorithms (e.g., ML/mb/Ms/Mwp, mantle magnitude (Mm), w-phase moment tensor, bodywave moment tensor, finite-fault inversion, array processing). The seismic library is organized in a way (function naming and usage) that will be familiar to users of Matlab. The seismic library extends sc3 so that it can be called by the real-time system, but it can also be driven and tested outside of sc3, for example, by ObsPy or Earthworm. To unify the three principal components we have developed a flexible and lightweight communication layer called SeismoEdex.

  2. U.S. Tsunami Information technology (TIM) Modernization: Performance Assessment of Tsunamigenic Earthquake Discrimination System

    Science.gov (United States)

    Hagerty, M. T.; Lomax, A.; Hellman, S. B.; Whitmore, P.; Weinstein, S.; Hirshorn, B. F.; Knight, W. R.

    2015-12-01

    Tsunami warning centers must rapidly decide whether an earthquake is likely to generate a destructive tsunami in order to issue a tsunami warning quickly after a large event. For very large events (Mw > 8 or so), magnitude and location alone are sufficient to warrant an alert. However, for events of smaller magnitude (e.g., Mw ~ 7.5), particularly for so-called "tsunami earthquakes", magnitude alone is insufficient to issue an alert and other measurements must be rapidly made and used to assess tsunamigenic potential. The Tsunami Information technology Modernization (TIM) is a National Oceanic and Atmospheric Administration (NOAA) project to update and standardize the earthquake and tsunami monitoring systems currently employed at the U.S. Tsunami Warning Centers in Ewa Beach, Hawaii (PTWC) and Palmer, Alaska (NTWC). We (ISTI) are responsible for implementing the seismic monitoring components in this new system, including real-time seismic data collection and seismic processing. The seismic data processor includes a variety of methods aimed at real-time discrimination of tsunamigenic events, including: Mwp, Me, slowness (Theta), W-phase, mantle magnitude (Mm), array processing and finite-fault inversion. In addition, it contains the ability to designate earthquake scenarios and play the resulting synthetic seismograms through the processing system. Thus, it is also a convenient tool that integrates research and monitoring and may be used to calibrate and tune the real-time monitoring system. Here we show results of the automated processing system for a large dataset of subduction zone earthquakes containing recent tsunami earthquakes and we examine the accuracy of the various discrimation methods and discuss issues related to their successful real-time application.

  3. Visualization of gold and platinum nanoparticles interacting with Salmonella Enteritidis and Listeria monocytogenes

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    Ewa Sawosz

    2010-08-01

    Full Text Available Ewa Sawosz1, André Chwalibog2, Jacek Szeliga3, Filip Sawosz2, Marta Grodzik1, Marlena Rupiewicz1, Tomasz Niemiec1, Katarzyna Kacprzyk11Division of Biotechnology and Biochemistry of Nutrition, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Basic Animal and Veterinary Sciences, University of Copenhagen, Copenhagen, Denmark; 3Division of Microbiology of Analytical Centre, Warsaw University of Life Sciences, Warsaw, PolandPurpose: Rapid development of nanotechnology has recently brought significant attention to the extraordinary biological features of nanomaterials. The objective of the present ­investigation was to evaluate morphological characteristics of the assembles of gold and platinum nanoparticles (nano-Au and nano-Pt respectively, with Salmonella Enteritidis (Gram-negative and Listeria monocytogenes (Gram-positive, to reveal possibilities of constructing bacteria-nanoparticle vehicles.Methods: Hydrocolloids of nano-Au or nano-Pt were added to two bacteria suspensions in the following order: nano-Au + Salmonella Enteritidis; nano-Au + Listeria monocytogenes; nano-Pt + Salmonella Enteritidis; nano-Pt + Listeria monocytogenes. Samples were inspected by transmission electron microscope.Results: Visualization of morphological interaction between nano-Au and Salmonella Enteritidis and Listeria monocytogenes, showed that nano-Au were aggregated within flagella or biofilm network and did not penetrate the bacterial cell. The analysis of morphological effects of interaction of nano-Pt with bacteria revealed that nano-Pt entered cells of Listeria monocytogenes and were removed from the cells. In the case of Salmonella Enteritidis, nano-Pt were seen inside bacteria cells, probably bound to DNA and partly left bacterial cells. After washing and centrifugation, some of the nano-Pt-DNA complexes were observed within Salmonella Enteritidis.Conclusion: The results indicate that the bacteria could be used as a vehicle to deliver nano

  4. A participação dos ergonomistas nos projetos organizacionais

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    Marçal Jackson

    1999-12-01

    Full Text Available Neste texto, pretende-se apresentar, em resposta às condicionantes conceituais e metodológicas colocadas por Salerno, uma abordagem metodológica, a abordagem da atividade futura (AAF, que viabiliza a participação dos ergonomistas em projetos organizacionais. Nessa abordagem, que tem a Análise Ergonômica do Trabalho (AET como base, os ergonomistas não sustentam unicamente a posição clínica, característica da AET, mas assumem o papel de "atores do processo de projeto" a fim de cooperar com os diferentes atores da empresa: diretores, gerentes, engenheiros, trabalhadores. Todavia, a participação efetiva da Ergonomia depende de nova forma de conceber a organização, que deve ser abordada não somente através de sua dimensão estrutural, mas também através das "regulações sociais necessárias à manutenção e à construção da organização do trabalho".In response to Salerno's theoretical and methodological constraints to ergonomists participation in organisational design process, this paper proposes a new approach based in future work activity forecasting. Even if the Ergonomie Work Analysis (EWA is the underlying methodological tool, in this approach, ergonomists must assume a new role, as "actors of the design process", and co-operate with the others company actors: managers, engineers, foremen and workers. But to be more effective, ergonomie intervention needs a new framework of "organisation" issues. To be more effective, it will be argued that one must approach organisâtionnal design not only by its structural components but also by its inherent social interactions and adjustments.

  5. Projections of high resolution climate changes for South Korea using multiple-regional climate models based on four RCP scenarios. Part 2: precipitation

    Science.gov (United States)

    Oh, Seok-Geun; Suh, Myoung-Seok; Lee, Young-Suk; Ahn, Joong-Bae; Cha, Dong-Hyun; Lee, Dong-Kyou; Hong, Song-You; Min, Seung-Ki; Park, Seong-Chan; Kang, Hyun-Suk

    2016-05-01

    Precipitation changes over South Korea were projected using five regional climate models (RCMs) with a horizontal resolution of 12.5 km for the mid and late 21st century (2026-2050, 2076- 2100) under four Representative Concentration Pathways (RCP) scenarios against present precipitation (1981-2005). The simulation data of the Hadley Centre Global Environmental Model version 2 coupled with the Atmosphere-Ocean (HadGEM2-AO) was used as boundary data of RCMs. In general, the RCMs well simulated the spatial and seasonal variations of present precipitation compared with observation and HadGEM2-AO. Equal Weighted Averaging without Bias Correction (EWA_NBC) significantly reduced the model biases to some extent, but systematic biases in results still remained. However, the Weighted Averaging based on Taylor's skill score (WEA_Tay) showed a good statistical correction in terms of the spatial and seasonal variations, the magnitude of precipitation amount, and the probability density. In the mid-21st century, the spatial and interannual variabilities of precipitation over South Korea are projected to increase regardless of the RCP scenarios and seasons. However, the changes in area-averaged seasonal precipitation are not significant due to mixed changing patterns depending on locations. Whereas, in the late 21st century, the precipitation is projected to increase proportionally to the changes of net radiative forcing. Under RCP8.5, WEA_Tay projects the precipitation to be increased by about +19.1, +20.5, +33.3% for annual, summer and winter precipitation at 1-5% significance levels, respectively. In addition, the probability of strong precipitation (≥ 15 mm d-1) is also projected to increase significantly, particularly in WEA_Tay under RCP8.5.

  6. Arthroscopic foveal repair of the triangular fibrocartilage complex.

    Science.gov (United States)

    Atzei, Andrea; Luchetti, Riccardo; Braidotti, Federica

    2015-02-01

    Background Foveal disruption of the triangular fibrocartilage complex (TFCC) is associated with distal radioulnar joint (DRUJ) instability. TFCC fixation onto the fovea is the suitable treatment, which is not achieved by conventional arthroscopic techniques. We describe an all-inside arthroscopic technique that uses a suture anchor through distal DRUJ arthroscopy for foveal repair of the TFCC. Materials and Methods Forty-eight patients with TFCC foveal tear and DRUJ instability were selected according to the Atzei-European Wrist Arthroscopy Society (EWAS) algorithm of treatment. Retrospective evaluation included pain, DRUJ instability, range of motion (ROM), grip strength, Modified Mayo Wrist Score (MMWS), and the Disabilities of the Arm, Shoulder, and Hand (DASH) Score. Description of Technique DRUJ arthroscopy was performed to débride the TFCC and the foveal area. Under arthroscopic guidance, a suture anchor was inserted via the distal foveal portal to repair the TFCC onto the fovea. Sutures were tied on the radiocarpal surface of the TFCC. Postoperative immobilization of forearm rotation was maintained for 4 weeks. Heavy tasks were allowed after 3 months. Results After a mean follow-up of 33 months, pain improved significantly but remained moderate in four patients, severe in one. DRUJ instability resolved in 44 patients. Wrist ROM increased. Grip strength, MMWS, and DASH score improved significantly. Excellent and good MMWS equaled 83.3%. Forty-one patients (85.5%) resumed previous work and sport activities. As a postoperative complication, five patients experienced neuroapraxia of the dorsal sensory branch of the ulnar nerve (DSBUN) with full spontaneous recovery. Conclusions With appropriate indications and patient selection, arthroscopic foveal repair of the TFCC may restore DRUJ stability and provide satisfactory results without significant complications.

  7. The intensity of A. Wat

    Directory of Open Access Journals (Sweden)

    Jerzy Kandziora

    2012-01-01

    Full Text Available The article discusses a collection of literary essays Elementy do portretu. Szkice o twórczości Aleksandra Wata published and edited by Poznań-based specialists in Polish literature and dedicated to Professor Ewa Wiegandt. The starting point for the discussion is the observation that the authors of the essays had to grapple with the elusiveness and multidimensional character of the output of A. Wat, with the entanglement of the text of his works with the text of his biography, and finally with the multitude of its cultural contexts. The reviewer distinguishes four research currents in the collection of essays, each being a different answer to these particular traits of Wat’s writing. Historical and literary studies in the book show the author in his relations and as a non-categorizable author, and challenge the Futurist character of his juvenile writings by juxtaposing them with earlier Symbolism and later Catastrophism. The interpretative study current tries to find ways to define Wat through reading his individual works. Here, the overriding opposition between ”closeness” and ”openness”, so pivotal in the poet’s works, becomes apparent. The current of thematology that present Wat’s literary topoi in relation to his biography is well represented in the volume. Finally, the studies that cross the strictly literary horizon try to capture the multi-tier structures of Wat’s works, reinterpreting them from the sociological, historical or axiological perspectives. The final conclusion of the review is the acknowledgement of the richness offered by the book that corresponds well to the intensity of works and the biography of the author.

  8. Toward a Taxonomy for Multi-Omics Science? Terminology Development for Whole Genome Study Approaches by Omics Technology and Hierarchy.

    Science.gov (United States)

    Pirih, Nina; Kunej, Tanja

    2017-01-01

    Omics is a form of high-throughput systems science. However, taxonomies for omics studies are limited, inviting us to rethink new ways in which we classify, prioritize, and rank various omics systems science studies. In this overarching context, the genome-wide study approaches have proliferated in number and popularity over the past decade. However, their hierarchy is not well organized and the development of attendant terminology is not controlled. In the present study, we searched the literature in PubMed and the Web of Science databases published from March 1999 to September 2016 using the keywords, including genome-wide, association, whole genome, transcriptome-wide, metabolome, epigenome, and phenome. We identified the whole genome study approaches and sorted them according to the omics technology types (genomics, proteomics, and so on) and hierarchy. Thirty-four studies from over 90 publications were sorted into 10 omics groups: DNA level, transcriptomics, proteomics, interactomics, metabolomics, epigenomics, miRNomics/ncRNomics, phenomics, environmental omics, and pharmacogenomics. We suggest here modifications of terminology for study approaches, which share the same acronyms such as EWAS for epigenome-wide association and environment-wide association studies, and MWAS for methylome-wide association and metabolome-wide association studies. Taken together, our study presented here provides the first systematic review and analyses of whole genome approaches and presents a baseline for further controlled terminology development, with a view to a new taxonomy for omics and multi-omics studies in the future. Finally, we call for greater dialogue and collaboration across diverse omics knowledge domains and applications, for example, across plants, animals, clinical medicine, and ecology.

  9. Sensitivity to environmental irritants and quality of life in COPD

    Directory of Open Access Journals (Sweden)

    Ternesten-Hasséus E

    2011-12-01

    Full Text Available Ewa Ternesten-Hasséus, Sven Larsson, Eva MillqvistDepartment of Internal Medicine/Respiratory Medicine and Allergology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenAbstract: It is a common clinical experience that patients with chronic obstructive pulmonary disease (COPD complain of airway symptoms provoked by environmental irritants like chemicals and scents, although few studies can confirm such connections. The aim was to study the prevalence of airway symptoms induced by chemicals and scents in a group of patients with newly diagnosed CPOD and to analyze any relation to illness severity and quality of life. Eighty-one patients with COPD were recruited to the study. By mail they were asked to answer three questionnaires regarding symptoms, quality of life, and social and emotional influence of airway symptoms induced by environmental irritants. A majority (62% of the COPD patients claimed to be hyperreactive to chemicals and scents. As a group they scored higher on a questionnaire measuring social and emotional influences of such environmental irritants compared to healthy control subjects. Further, high scores were more common among patients with a very severe form of COPD and among patients with regular use of β2-stimulants. High scores were also associated with significantly more airway symptoms and, in some aspects, with impaired quality of life. In conclusion, the results of this study show that airway symptoms induced by environmental irritants are common in patients with COPD and that this increased airway sensitivity follows the impairment of lung capacity. The mechanisms behind this remain unclear.Keywords: COPD, hyperresponsiveness, environmental irritants, sensory hyperreactivity, quality of life

  10. Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy.

    Science.gov (United States)

    Morales, Eva; Vilahur, Nadia; Salas, Lucas A; Motta, Valeria; Fernandez, Mariana F; Murcia, Mario; Llop, Sabrina; Tardon, Adonina; Fernandez-Tardon, Guillermo; Santa-Marina, Loreto; Gallastegui, Mara; Bollati, Valentina; Estivill, Xavier; Olea, Nicolas; Sunyer, Jordi; Bustamante, Mariona

    2016-10-01

    We conducted an epigenome-wide association study (EWAS) of DNA methylation in placenta in relation to maternal tobacco smoking during pregnancy and examined whether smoking-induced changes lead to low birthweight. DNA methylation in placenta was measured using the Illumina HumanMethylation450 BeadChip in 179 participants from the INfancia y Medio Ambiente (INMA) birth cohort. Methylation levels across 431 311 CpGs were tested for differential methylation between smokers and non-smokers in pregnancy. We took forward three top-ranking loci for further validation and replication by bisulfite pyrosequencing using data of 248 additional participants of the INMA cohort. We examined the association of methylation at smoking-associated loci with birthweight by applying a mediation analysis and a two-sample Mendelian randomization approach. Fifty CpGs were differentially methylated in placenta between smokers and non-smokers during pregnancy [false discovery rate (FDR) < 0.05]. We validated and replicated differential methylation at three top-ranking loci: cg27402634 located between LINC00086 and LEKR1, a gene previously related to birthweight in genome-wide association studies; cg20340720 (WBP1L); and cg25585967 and cg12294026 (TRIO). Dose-response relationships with maternal urine cotinine concentration during pregnancy were confirmed. Differential methylation at cg27402634 explained up to 36% of the lower birthweight in the offspring of smokers (Sobel P-value < 0.05). A two-sample Mendelian randomization analysis provided evidence that decreases in methylation levels at cg27402634 lead to decreases in birthweight. We identified novel loci differentially methylated in placenta in relation to maternal smoking during pregnancy. Adverse effects of maternal smoking on birthweight of the offspring may be mediated by alterations in the placental methylome. © The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International

  11. Adjustment of Cell-Type Composition Minimizes Systematic Bias in Blood DNA Methylation Profiles Derived by DNA Collection Protocols.

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    Yuh Shiwa

    Full Text Available Differences in DNA collection protocols may be a potential confounder in epigenome-wide association studies (EWAS using a large number of blood specimens from multiple biobanks and/or cohorts. Here we show that pre-analytical procedures involved in DNA collection can induce systematic bias in the DNA methylation profiles of blood cells that can be adjusted by cell-type composition variables. In Experiment 1, whole blood from 16 volunteers was collected to examine the effect of a 24 h storage period at 4°C on DNA methylation profiles as measured using the Infinium HumanMethylation450 BeadChip array. Our statistical analysis showed that the P-value distribution of more than 450,000 CpG sites was similar to the theoretical distribution (in quantile-quantile plot, λ = 1.03 when comparing two control replicates, which was remarkably deviated from the theoretical distribution (λ = 1.50 when comparing control and storage conditions. We then considered cell-type composition as a possible cause of the observed bias in DNA methylation profiles and found that the bias associated with the cold storage condition was largely decreased (λ adjusted = 1.14 by taking into account a cell-type composition variable. As such, we compared four respective sample collection protocols used in large-scale Japanese biobanks or cohorts as well as two control replicates. Systematic biases in DNA methylation profiles were observed between control and three of four protocols without adjustment of cell-type composition (λ = 1.12-1.45 and no remarkable biases were seen after adjusting for cell-type composition in all four protocols (λ adjusted = 1.00-1.17. These results revealed important implications for comparing DNA methylation profiles between blood specimens from different sources and may lead to discovery of disease-associated DNA methylation markers and the development of DNA methylation profile-based predictive risk models.

  12. [First responder defibrillation in the LAGO-die Therme--results and experiences].

    Science.gov (United States)

    Trappe, H-J; Nesslinger, M; Schrage, O M; Wissuwa, H; Becker, H-J

    2005-06-01

    The use of automated external defibrillator (AED) by persons other than paramedics and emergency medical technicians is advocated by several US- and European organizations. However, at the present time it is still unclear to identify public places with a high incidence of out-of-hospital cardiac arrest. There are few data on the potential impact of public access defibrillators on survival after out-of-hospital cardiac arrest in sporting arenas or water parks. Therefore, we studied prospectively incidence of out-of-hospital cardiac arrest in the LAGO-die Therme in Herne. This is one of the most important swimming parks in Europe and member of the European Waterpark Association EWA. Eight AEDs were placed in the waterpark LAGO-die Therme. The locations where the defibrillators were stored were chosen to make possible a target interval of 60 seconds from collapse to first defibrillation. Twenty waterpark officers were instructed in cardiopulmonary resuscitation and in the use of the AED. During November 16, 2001 and December 31, 2004, 2.05 Mio. visitors were counted in the LAGO. Out-of-hospital cardiac arrest occurred in none of them. AED were used in two visitors with non arrhythmogenic syncope, no shock was delivered. Questionaires were done in 588 visitors (336 males, 252 females, mean age 38+21 years) in 2002 and in 579 visitors (322 males, 257 females, mean age 37+/-25 years) in 2004. In 2002, 77% of the visitors noticed the AED and, therefore, 49% performed more sporting activities. In addition, in 2004, AED was noticed by 480 visitors (83%) and 277 visitors (48%) did more sporting activities. There were no significant differences between 2002 and 2004 (p=ns). Despite no out-of-hospital cardiac arrest in the waterpark during the 3 year follow- up, it seems reasonable to install AED in sporting places with thousands of visitors per year.

  13. The role of international collaboration in knowledge development in creation of TSO

    Energy Technology Data Exchange (ETDEWEB)

    Jackowski, Tomasz Marian; Skrzypek, Elena; Spirzewski, Michal [National Centre for Nuclear Research, Otwock (Poland)

    2014-12-15

    National Centre for Nuclear Research has been created on September the 1{sup st} 2011 by the decree of the Polish Government with a clear goal to form Technical Support Organization for Polish regulator and public administration. It was done by merging two institutes, the former Institute of Atomic Energy POLATOM and the former Andrzej Soltan Institute for Nuclear Studies, which worldwide reputation and successful research in various fields of nuclear power-related studies are well known. The fields of activity are widely focused on the nuclear physics, cosmology, electronics as well as detectors, accelerators, material research and many more. The main factor of National Center for Nuclear Research development was the participation in the European Structural Founds program ''Swierk Computing Centre'' from the beginning. In the frame of this particular program, the collaboration with the IAEA, NEA OECD, Euratom and research and TSO organizations from different countries began. The international collaboration plays the key role in the development of the Technical Support Organization expertise, which aim is to become the institution able to provide experts' support for decision-makers in nuclear power industry in Poland. Expertise and knowledge is expanded by the engagement in the code users international trainings, by being involved in various projects and benchmarks. The National Centre for Nuclear Research participates in, among the others, EURATOM projects such as NURESAFE (creation of BE Codes platform). Moreover NCBJ is involved in EURATOM FP7 projects such as NC2I-R (Cogeneration Initiative), ASAMPSAE (Advanced PSA), and ALLIANCE as part of the ALLEGRO project. In most of these groups our centre is taking active part in development as well as in management activities. Thanks to experiences gained and with work on research we are effectively expanding knowledge, experience and expertise to meet future's demands as a Technical

  14. Treatment adherence in patients with type 2 diabetes mellitus correlates with different coping styles, low perception of self-influence on disease, and depressive symptoms

    Directory of Open Access Journals (Sweden)

    Kokoszka A

    2017-03-01

    Full Text Available Andrzej Kokoszka1,2 1II Department of Psychiatry, Medical University of Warsaw, 2Department of Psychology, SWPS University of Social Sciences and Humanities, Warsaw, Poland Background: Insulin analogs are regarded as more convenient to use than human insulin; however, they require a different administration scheme due to their unique pharmacokinetic and pharmacodynamic properties. This study aimed to assess difficulties with adherence to treatment with insulin analogs in patients with type 2 diabetes mellitus (T2DM, who had previously been treated with human insulin. The associations between difficulties with adherence and clinical, demographic, and psychological characteristics were also evaluated.Patients and methods: The study was conducted on 3,467 consecutively enrolled patients with T2DM (54.4% women, mean age 63.9 years (SD =9.57, who had recently undergone a physician-directed change in treatment from human insulin to insulin analogs. The questionnaires addressed difficulties with switching the therapy, coping styles, well-being, and perception of self-influence on the disease.Results: No adherence problems in switching therapy were reported in 56.6% of patients. Specific moderate difficulties were reported in 10.4%–22.1% of patients, major difficulties in 0.7%–6.9% of patients, and very significant difficulties in 0.03%–1.3% of patients. Overall, remembering to modify the insulin dose in the case of additional meals was the most frequently reported difficulty, and problems with identifying hypoglycemic symptoms were the least frequently reported. The increased risk of difficulties was moderately related to low perception of self-influence on diabetes and poor well-being. The intensity of problems was higher among those who were less-educated, lived in rural areas, had complications, and/or reported maladaptive coping styles.Conclusion: Switching from human insulin to an insulin analog did not cause adherence problems in more than

  15. The influence of frailty syndrome on acceptance of illness in elderly patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Uchmanowicz I

    2016-09-01

    Full Text Available Izabella Uchmanowicz,1 Beata Jankowska-Polanska,1 Mariusz Chabowski,2 Bartosz Uchmanowicz,1 Andrzej M Fal3 1Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 2Division of Nursing in Surgical Procedures, Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, 3Department of Healthcare Organisation and Economics, National Institute of Public Health, National Institute of Hygiene, Warsaw, Poland Abstract: COPD is one of the most debilitating diseases. Frailty syndrome and advanced age may decrease the acceptance of illness, quality of life, and worsen health conditions in these patients, as well as lead to an increase in health care expenses. The aim of the study was to assess how the level of frailty affects the acceptance of illness in elderly patients with COPD. We also aimed to evaluate the associations between sociodemographic and clinical factors and the level of acceptance of illness, anxiety, and frailty in this group of patients. The study included 102 COPD patients with a mean age of 63.2 (standard deviation =6.5 years and grades I (3%, II (37%, III (52%, and IV (8% by Global Initiative for Chronic Obstructive Lung Disease. The Polish versions of the Acceptance of Illness Scale and Tilburg frailty indicator were used. Frailty syndrome was found in 77 (75.5% patients, with an average score of 7.42 (standard deviation =2.24. Coexisting diseases such as hypertension (46.07%, coronary artery disease (32.35%, heart failure (28.43%, diabetes (18.63%, and heart arrhythmia (9.8% were found among the subjects. The overall level of acceptance of illness was 20.6 (standard deviation =7.62. A lower level of acceptance of illness was associated with a higher level of frailty, especially in the physical and social domain. Elderly patients with severe COPD are more prone to frailty and decreased acceptance of their disease in comparison to patients with other chronic diseases

  16. Effects of immunosuppressive treatment on protein expression in rat kidney

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    Kędzierska K

    2014-09-01

    Full Text Available Karolina Kędzierska,1 Katarzyna Sporniak-Tutak,2 Krzysztof Sindrewicz,2 Joanna Bober,3 Leszek Domański,1 Mirosław Parafiniuk,4 Elżbieta Urasińska,5 Andrzej Ciechanowicz,6 Maciej Domański,1 Tomasz Smektała,2 Marek Masiuk,5 Wiesław Skrzypczak,6 Małgorzata Ożgo,6 Joanna Kabat-Koperska,1 Kazimierz Ciechanowski1 1Department of Nephrology, Transplantology, and Internal Medicine, 2Department of Dental Surgery, 3Department of Medical Chemistry, 4Department of Forensic Medicine, 5Department of Pathomorphology, Pomeranian Medical University, 6Department of Physiology, Cytobiology, and Proteomics, West Pomeranian University of Technology, Szczecin, Poland Abstract: The structural proteins of renal tubular epithelial cells may become a target for the toxic metabolites of immunosuppressants. These metabolites can modify the properties of the proteins, thereby affecting cell function, which is a possible explanation for the mechanism of immunosuppressive agents' toxicity. In our study, we evaluated the effect of two immunosuppressive strategies on protein expression in the kidneys of Wistar rats. Fragments of the rat kidneys were homogenized after cooling in liquid nitrogen and then dissolved in lysis buffer. The protein concentration in the samples was determined using a protein assay kit, and the proteins were separated by two-dimensional electrophoresis. The obtained gels were then stained with Coomassie Brilliant Blue, and their images were analyzed to evaluate differences in protein expression. Identification of selected proteins was then performed using mass spectrometry. We found that the immunosuppressive drugs used in popular regimens induce a series of changes in protein expression in target organs. The expression of proteins involved in drug, glucose, amino acid, and lipid metabolism was pronounced. However, to a lesser extent, we also observed changes in nuclear, structural, and transport proteins' synthesis. Very slight differences

  17. Sex differences in TGFB-β signaling with respect to age of onset and cognitive functioning in schizophrenia

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    Frydecka D

    2015-03-01

    Full Text Available Dorota Frydecka,1 Błazej Misiak,1,2 Edyta Pawlak-Adamska,3 Lidia Karabon,3,4 Anna Tomkiewicz,3 Paweł Sedlaczek,5 Andrzej Kiejna,1 Jan Aleksander Beszłej1 1Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; 2Department of Genetics, Wroclaw Medical University, Wroclaw, Poland; 3Laboratory of Immunopathology, Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland; 4Department of Clinical Urology, Wroclaw Medical University, Wroclaw, Poland; 51st Department and Clinic of Gynecology and Obstetrics, Wroclaw Medical University, Wroclaw, Poland Abstract: There are studies showing that gene polymorphisms within the transforming growth factor-β (TGF-β signaling constitute schizophrenia risk variants. However, the association between TGFB1 gene polymorphisms (+869T/C and +915G/C, TGF-β level with schizophrenia course, and its symptomatology together with cognitive functioning has not been investigated so far. We included 151 patients with schizophrenia and 279 healthy controls. Cognitive functioning was assessed using Rey Auditory Verbal Learning Test, Trail Making Test (TMT-A and TMT-B, Verbal Fluency task, Stroop test, as well as selected subtests from the Wechsler Adults Intelligence Scale – Revised, Polish adaptation (WAIS-R-Pl: Digit Symbol Coding, Digit Span Forward and Backward, and Similarities. Additionally, serum TGF-β levels were measured in 88 schizophrenia patients and 88 healthy controls. Serum TGF-β level was significantly higher among patients with schizophrenia in comparison with healthy controls; however, the studied polymorphisms were not associated with TGF-β level in schizophrenia patients. Subjects carrying the +869T allele performed significantly worse in comparison with +869CC homozygotes on Stroop task, Verbal Fluency task and Digit Symbol Coding task. There was a significant difference in age of psychosis onset in female

  18. Predicting acute side effects of stimulant medication in pediatric attention deficit/hyperactivity disorder: data from quantitative electroencephalography, event-related potentials, and a continuous-performance test

    Directory of Open Access Journals (Sweden)

    Ogrim G

    2013-09-01

    Full Text Available Geir Ogrim,1–3 Knut A Hestad,3,4 Jan Ferenc Brunner,3,5,6 Juri Kropotov3,7,8 1Neuropsychiatric Unit, Østfold Hospital Trust, Fredrikstad, Norway; 2National Resource Center for ADHD, Tourettes' Syndrome and Narcolepsy, Oslo, Norway; 3Institute of Psychology, Norwegian University of Science and Technology (NTNU, Trondheim, Norway; 4Division of Mental Health, Innlandet Hospital Trust, Brumunddal, Norway; 5Department of Physical Medicine and Rehabilitation, St Olav's Hospital, Trondheim, Norway; 6Department of Neuroscience, NTNU, Trondheim, Norway; 7Institute of the Human Brain, Russian Academy of Sciences, Saint Petersburg, Russia; 8Department of Neuropsychology, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland Background: The aim of this study was to search for predictors of acute side effects of stimulant medication in pediatric attention deficit/hyperactivity disorder (ADHD, emphasizing variables from quantitative electroencephalography (QEEG, event-related potentials (ERPs, and behavior data from a visual continuous-performance test (VCPT. Methods: Seventy medication-naïve ADHD patients aged 7–16 years were tested with QEEG, including a go/no-go task condition (VCPT from which behavior data and ERPs were extracted, followed by a systematic trial on stimulant medication lasting at least 4 weeks. Based on data from rating scales and interviews, two psychologists who were blind to the QEEG/ERP test results independently rated the patients as having no or small side effects (n = 37 or troublesome side effects (n = 33. We determined if the side effects were related to sex, age, IQ, ADHD subtype, comorbidities, clinical outcome, and variables in QEEG, ERPs, and VCPT. Results: There was a moderate negative correlation between clinical outcome and side effects. Three variables were significantly associated with side effects in a multivariate logistic regression analysis. In the ERP independent component – contingent negative variation

  19. [Princess Anna Vasa--her fascinating life story and skeleton].

    Science.gov (United States)

    During, Ebba

    2005-01-01

    The Princess Anna Vasa was born in Sweden in 1568 and spent her first 19 years there. She was the daughter of the Swedish king Johan III and his wife, the Polish Royal Princess Katarina Jagellonica. She was brought up as a Catholic but converted to be a Protestant already in 1583 and remained a fervent Protestant to the end of her life. She was an exceptionally intelligent and extensively educated woman. When her brother became king, Sigismund III of Poland, she accompanied him there. She exerted great influence on Sigismund who was brought up to be a Catholic. She was persistent in her religion, yet working for religious liberty. "The Swedish Princess" was also named "the Queen of Polish Botany". She was never married and she died 57 years old in 1625. For religious reasons her body had to wait 11 years for a funeral of royal standing. The funeral took place in 1636 in St Mary's Church in Torun, Poland. During restoration work at the church in April 1994, Anna Vasa's skeleton was removed from the tomb, and an antropological investigation in order to establish her identity was carried by Dr Andrzej Florkowski at the Dept of Anthrop, Nicholas Copernicus University of Torun. I was invited to Torun to examine her remains in May 1995. The skeleton was in a rather good state of preservation. However, her grave had been plundered at least twice. Her skeleton lacked the right forearm and hand, probably as the result of the pillage of her rings and bracelets. Some other bones and teeth were also missing. At our ocular examination the skeleton revealed a number of anatomical deformations and pathological changes. A conventional radiography and CT of Anna Vasa's skeletal remains was later carried out in 1995 by M. Grzegorzewski, Z. Boron and W. Lasek at the Dept of Radiology, Med. Acad. of Bydgoszcz, Polen. A DNA-analysis was carried out by Dr Anders Götherström at the Archaeol. Res. Lab., Stockholm Univ. An odontological and radiological study was performed by Dr Sigrid I

  20. Urology in Stettin (Szczecin). The impact of political changes on progress in urology and medicine.

    Science.gov (United States)

    Zajaczkowski, Tadeusz; Wojewska-Zajaczkowska, Elzbieta

    2012-01-01

    with the Second Department of Surgery was opened in the district of Pomorzany. The head of the new ward was Dr. Alfons Wojewski (1912-1992), surgeon and urologist from Gdańsk (Danzig). In 1962, the ward was transformed into a separate Department of Urology with 62 beds. Prof. Wojewski organized the Department from its foundations, leading it quickly to the level of modern departments in the area of research, teaching, and therapy. After the retirement of Prof. Wojewski, the acting head of the department was Dr. Stanisław Krasoń until his death in 1986. He was followed for almost one year by Dr. Stanisława Spoz. Since May 1987, the head of the Department is Prof. Andrzej Sikorski from Łódź.

  1. The Spanish Case for Europe. The Power of Cultural Identity

    Directory of Open Access Journals (Sweden)

    Gonzalo Navajas

    2009-06-01

    Full Text Available Europe has not been for Spain an easily assumed identity, a home within which Spaniards could find accommodation. Yet, for the first time in modern history, Spain has become fully integrated in the political and economic system of Europe and it functions within it as a strong and dedicated partner. Paradoxically, this new order has developed simultaneously with the increasing assertion of the local nationalities. I propose that the current political and cultural situation in both Europe and Spain has created the appropriate conditions for an extensive reexamination of the conventional European/Spanish paradigm. That is so because the circumstances on both ends of the relation have changed and, for the first time, both sides not only desire but they need the reconstruction and redefinition of a relation that has been destructive for both parts. What Francisco José de Goya, Julián Sanz del Río, and Manuel Azaña, among others, conceived as a nearly impossible and illusory task can now become a reality. From Francisco Zurbarán, El Greco and Pedro Calderón de la Barca to Federico García Lorca, Luis Buñuel and Pablo Picasso, the various manifestations of its culture have been Spain’s unquestioned achievement. This cultural continuum is the most promising entryway for Spain in the Heimat of Europe. I also propose that the issue of the various historical nationalities within Spain can be approached from the perspective of what Andrzej Stasiuk calls the “private histories” of the minorities of Europe. In the last part of the article, I study Spain’s transcontinental identity. Without ignoring the legitimate issues raised by private narratives, I suggest that the country’s full insertion in the global reality and its immersion in realities that are beyond its own will lead to the contextualization of the internal national divide and the emergence of new and more productive approaches towards its resolution.

  2. Foreword

    Energy Technology Data Exchange (ETDEWEB)

    Sujkowski, Z. [The Andrzej Soltan Institute for Nuclear Studies, Otwock-Swierk (Poland)

    1998-12-31

    The year 1997 was marked by the hundredth birthday anniversary of professor Andrzej Soltan, the first director of our Institute and the pioneer of nuclear physics in Poland. It is also about hundred years since nuclear physics has begun with the discovery of Polonium and Radium by Maria Sklodowska-Curie and Pierre Curie. In honour of these anniversaries an Exhibition entitled ``Nuclear Physics and Nuclear Technique in Service of Medicine - from Radium Needle to Accelerators`` has been organized. Some lectures, radio broadcasts, popular level articles have supplemented this effort to bring the present day nuclear sciences closer to the general public. In the year of 1997 227 articles in international journals have been published, supplemented by 24 invited talks and 219 communications at conferences. The lists of these publications are given separately for each of the Research Departments throughout this Annual Report. They are preceded by articles on the work in progress and by the brief overviews written by the Department Heads. The selected highlights of the past year are: progress in materials science (deep surface layers - on transformation of uranium lattice induced by water corrosion). The work on modification of surface properties by hot and cold ion implantation. In nuclear physics the careful study of polarization phenomena in the decay of light, weekly bound nuclei. The works on the properties of the heaviest elements have been continued (Adam Sobiczewski - international prizes: in 1997 the Alfred Jurzykowski and the Flerov prize). The study of new scintillation techniques provided by Marek Moszynski has also mentioned. The highlight this time is the demonstration of advantages offered by avalanche diodes for the light output readout. The particle physicists continue their involvement in various international projects. This year they managed to give a noteworthy instrumental and technical input to: Resistive Plate Chambers for the Compact Muon Solenoid

  3. Effect of a nonsurgical treatment program on the gait pattern of idiopathic toe walking: a case report

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    Szopa A

    2016-02-01

    Full Text Available Andrzej Szopa,1 Małgorzata Domagalska-Szopa,2 Weronika Gallert-Kopyto,1 Wojciech Kiebzak,3 Ryszard Plinta4 1Department of Physiotherapy, 2Department of Medical Rehabilitation, School of Health Sciences, Medical University of Silesia, Katowice, 3Faculty of Health Sciences, Jan Kochanowski University, Kielce, 4Department of Adapted Physical Activity and Sport, School of Health Sciences, Medical University of Silesia, Katowice, Poland Background: Recent studies have reported many possibilities for the treatment of idiopathic toe walking (ITW; however, none of them have been sufficiently documented. The purpose of this case study was to document the evolution of the gait pattern of a child with severe ITW using the Gillette Gait Index before and after the third and sixth weeks, a nonsurgical treatment program and then every 3 months to 1 year from the start of the treatment. This is significant because the case study shows that a nonsurgical treatment program can be an alternative treatment method for children with severe ITW.Case description: The case study involved a 5-year-old boy diagnosed with severe ITW. An orthopedist recommended a surgical treatment, but his parents refused to provide consent.Intervention: The subject participated in a 12-week nonsurgical treatment program that used tone-inhibiting casts (TICs combined with physiotherapy based on neurodevelopmental treatment principles. The treatment protocol included the following: 1 precast preparation; 2 TICs with treatment; and 3 post-cast treatment to improve the gait pattern.Outcomes: After treatment with TICs, the range of motion of ankle dorsiflexion during stance had increased, resulting in an almost normalized gait. The patient stopped toe walking for at least 1 year.Discussion: This study demonstrates that nonsurgical treatment should be considered first, with surgical options reserved for resistant cases; however, further research is required given the current lack of knowledge

  4. Factors related to changes in the quality of life among Polish adolescents and adults with cystic fibrosis over a 1-year period

    Directory of Open Access Journals (Sweden)

    Dębska G

    2015-12-01

    Full Text Available Grażyna Dębska,1 Henryk Mazurek2 1Faculty of Health and Medical Studies, Andrzej Frycz Modrzewski Krakow University, Krakow, 2Department of Pneumonology and Cystic Fibrosis, National Tuberculosis and Lung Diseases Research Institute, Rabka, Poland Background: The aim of this study was to determine the effects of clinical factors, physical activity, and sociodemographic variables on 1-year changes in health-related quality of life (HRQoL in Polish adolescents and adults with cystic fibrosis (CF.Method: The study included 67 subjects with CF (mean age 21.1±5.1 years; range 14–37 years; 34 males and 33 females. The Cystic Fibrosis Quality of Life Questionnaire was used at baseline and after 1 year. Lung function data, body weight, and body height were extracted from medical records. Clinical assessment was performed with the Shwachman–Kulczycki scale.Results: The highest scores in both HRQoL examinations came from the domains of physical and social functioning, and the lowest from future concerns, body image, and career concerns. No significant changes of Cystic Fibrosis Quality of Life Questionnaire scores were documented over a period of 1 year. Patients with better baseline spirometry results more frequently reported an improvement in the treatment issues (subjects with FEV1 >50% of predicted, P=0.020 and in the career concerns (patients with FVC >50% of predicted, P=0.039. The improvement in the career concerns also depended upon daily physical activity (P=0.024, which was shown to modulate future concerns (P=0.032, along with place of residence and living conditions (P=0.003. Moreover, the time elapsed from the last pulmonary exacerbation was related to the change in social functioning (P=0.026.Conclusion: When planning treatment, attention should be paid to interventions which may improve HRQoL. Systematic chronic therapy improves lung function, related to treatment issues and career concerns. Maintaining good physical condition and

  5. 国际有色金属期货市场VaR和ES风险度量功效的比较%Comparative research between VaR and ES on international nonferrous metals futures market

    Institute of Scientific and Technical Information of China (English)

    杨娴; 陆凤彬; 汪寿阳

    2011-01-01

    采用历史模拟法、蒙特卡罗模拟法、指数加权法、等权重法、GARCH法和极值理论法六种参数方法和非参数方法对国际有色金属期货市场风险值VaR建模,并引入基于极值理论的预期不足ES对风险度量进行补充.在利用返回检验对实证结果的功效进行比较研究的基础之上,得出结论:从对ES和VaR的检验结果比较而言,当有色金属期货市场价格出现大幅跌涨时,ES比VaR更能准确地度量市场风险;从对各种方法VaR的检验结果比较而言,在95%的置信度下,GARCH法和指数加权法能够更加有效地度量市场风险,在99%的置信度下,指数加权法、GARCH法和历史模拟法能够更好地估计市场风险.%In view that the volatility of International Nonferrous Metals Market has direct and profound impact on the cost of production and the development of economy in China, we estimated the VaR of the futures market using Historical Simulation (HS), Monte Carlo method (MC), Exponentially Weighted Moving Average approach (EWMA), Equally Weighted approach (EWA), GARCH and Extreme Value Theory (EVT) separately. Then, we estimated the ES of the futures market based on EVT. Finally, we adopted backtest to evaluate the power of each method. Our findings indicate that ES is better than VaR in evaluating market risks when there is a sharp fall or rise in commodity prices; GARCH and EWMA gain an advantage over the other four methods with a 95% level of confidence; EWMA, GARCH and HS gain an advantage over the other three methods with a 99% level of confidence.

  6. Assessment of the risk of falling with the use of timed up and go test in the elderly with lower extremity osteoarthritis

    Directory of Open Access Journals (Sweden)

    Zasadzka E

    2015-08-01

    Full Text Available Ewa Zasadzka,1 Adrianna Maria Borowicz,1 Magdalena Roszak,2 Mariola Pawlaczyk1 1Department of Geriatric Medicine and Gerontology, Karol Marcinkowski University of Medical Sciences, 2Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland Background: Falling in the elderly results in a significant number of admissions to hospitals and long-term care facilities, especially among patients with lower extremity osteoarthritis (OA.Objective: The aim of the study was to assess the risk of falling in adults older than 60 years with OA using timed up and go (TUG test.Materials and methods: A total of 187 patients (aged >60 years were enrolled in the study. The assessment included: basic activities of daily living (ADLs, lower extremity strength with the use of the 30-second chair stand test (30 CST, and assessment of the risk of falling (TUG test. Pain intensity was evaluated with the numeric rating scale (NRS.Results: The TUG test results were significantly better in younger OA patients (aged 60–69 years, as compared with their older peers (aged 70–79 years; P<0.01 and the oldest group (aged >80 years; P<0.001. Also, the 30 CST results were significantly higher in younger OA patients (P<0.05. Subjects older than 80 years had a significantly worse ADL score (P<0.05 and P<0.001. Pain complaints were reported significantly more frequently by women than men (P<0.05. A correlation between age and the TUG test score (r=0.412; P<0.0004 as well as between the TUG test and the 30 CST scores (r=0.7368; P=0.000 was detected. In the group with the TUG test score of <13.5 seconds, the 30 CST (P<0.0001 and ADL (P<0.003 results were significantly better. A comparison of fallers vs nonfallers revealed that the number of falls was significantly higher in the group of subjects who scored $13.5 when compared to <13.5 (P=0.003. Fallers significantly more often reported pain (P<0.0001, whereas nonfallers had

  7. Biomarkers of Parkinson's disease: present and future.

    Science.gov (United States)

    Miller, Diane B; O'Callaghan, James P

    2015-03-01

    of exposome-wide association studies (EWAS) to profile omic features in serum to discover molecular biomarkers. The second stage involves application of this knowledge base in follow-up studies. This strategy is unique in that it promotes the use of data-driven (omic) strategies in interrogating diseased and healthy populations and encourages a movement away from using only reductionist strategies to discover biomarkers of exposure and disease. In this short review we will examine 1) advances in our understanding of the molecular mechanisms underlying PD that have led to candidate biomarkers for diagnosis and treatment efficacy and 2) new technologies on the horizon that will lead to novel approaches in biomarker development.

  8. As estratégias operatórias e a gestão da informação no trabalho de enfermagem, no contexto hospitalar Las estrategias operatórias y la gestión de la información del trabajo de enfermeros en el entorno hospitalario The operatory strategies and information process of the nursing work in hospital context

    Directory of Open Access Journals (Sweden)

    Diana Lúcia Moura Pinho

    2003-03-01

    Full Text Available O estudo analisa as estratégias operatórias de gestão da informação, utilizadas pelos enfermeiros no contexto hospitalar para regular o trabalho. O quadro teórico inscreve-se no campo da ergonomia, articulando conceitos de regulação da atividade, representações para e na ação. A Análise Ergonômica do Trabalho - AET orientou a coleta de dados. Os resultados demonstram que as estratégias adotadas pelos enfermeiros apóiam-se na utilização de um recurso informal externo (anotações pessoais que visa, sobretudo, reduzir a carga mental de trabalho e garantir a fiabilidade de suas ações.El presente estudio investiga las estrategias operatorias en la gestión de la información utilizadas por los enfermeros, en el entorno hospitalario, para regular su trabajo. El cuadro teórico de referencia adoptado se incluye en el campo de la ergonomía articulando conceptos de conducta de regulación y representaciones para y en la acción. El " Análisis Ergonómico del Trabajo - AET " orientó la recolección de los datos. Los resultados demuestran que las estrategias cognitivas adoptadas por los enfermeros en la gestión de la información se apoya en la elaboración de anotaciones personales, con el objetivo, sobretodo, de reducir la carga de trabajo mental y garantizar la fiabilidad de sus acciones.The paper examines the relationship between operatory strategies and information process used by nurses, in hospital context, in order to regulate their ongoing activities. As a conceptual framework, a cognitive ergonomics model was adopted, linking concepts of work regulation and representation to action. The Ergonomics Work Analyses tool (EWA was used to collect data. The results show that the cognitive strategies used by nurses, in the decision-making process, are based on their ongoing activities as in the preparation of personal notes, aiming, in particular, at reducing their mental workload and assuring the viability of their actions.

  9. Tsunami Warning Services for the Caribbean Region

    Science.gov (United States)

    Whitmore, P. M.; Ferris, J. C.; Weinstein, S. A.

    2007-05-01

    Tsunami warning and watch services are currently provided to the Caribbean region through a collaborative effort between the two NOAA Tsunami Warning Centers (TWCs): the Pacific Tsunami Warning Center (PTWC) in Ewa Beach, Hawaii, and the West Coast/Alaska Tsunami Warning Center (WCATWC) in Palmer, Alaska. The WCATWC, in coordination with the Puerto Rico Seismic Network (PRSN), provides fast-response warning services to the U.S. territories of the Commonwealth of Puerto Rico and the U.S. Virgin Islands (PR/VI). The PTWC provides regional watch services to other countries throughout and surrounding the Caribbean Sea as part of the Intergovernmental Coordination Group for the Caribbean Sea and Adjacent Regions. This collaboration is analogous to the TWC's responsibilities in the Pacific basin: the WCATWC provides fast-response warning services for the U.S. west coast states, Alaska, and British Columbia in Canada, while the PTWC provides regional services for countries throughout and surrounding the Pacific Ocean (as well as a fast-response service for the U.S. State of Hawaii). Caribbean seismic data are transmitted to the TWCs through several means. The PRSN directly exports data to the WCATWC, providing the Center sufficient seismic data for the PR/VI region. Additionally, the PRSN provides the TWCs with data gathered from other Caribbean nations. Using modern communication capabilities, the seismic data can be processed at the TWCs at the same time it is processed locally. Another source of high- quality seismic data is the new USGS nine-station array that circles the region. The Global Seismic Network maintains several stations in Caribbean, Central American, and South American nations which are available in real-time to the TWCs. Unfortunately, sea level data coverage is sporadic in the region. The PR/VI has a relatively dense array of coastal tide gages, but coastal tide gage coverage is very sparse for the rest of the Caribbean basin. Three deep-ocean pressure

  10. Effect of Nordic Walking training on iron metabolism in elderly women

    Directory of Open Access Journals (Sweden)

    Kortas J

    2015-11-01

    Full Text Available Jakub Kortas,1 Katarzyna Prusik,2 Damian Flis,3 Krzysztof Prusik,1 Ewa Ziemann,4 Neil Leaver,5 Jedrzej Antosiewicz6 1Department of Recreation and Tourism, Gdansk University of Physical Education and Sport, Gdansk, Poland; 2Department of Biomedical Basis of Health, Gdansk University of Physical Education and Sport, Gdansk, Poland; 3Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, Gdansk, Poland; 4Department of Physiology and Pharmacology, Gdansk University of Physical Education and Sport, Gdansk, Poland; 5The Immunosuppression monitoring service (IMS Laboratory, Royal Brompton & Harefield NHS Foundation Trust, Heart Science Centre, Harefield Hospital, Harefield, UK; 6Department of Biochemistry, Gdansk University of Physical Education and Sport, Gdansk, Poland Background: Despite several, well-documented pro-healthy effects of regular physical training, its influence on body iron stores in elderly people remains unknown. At the same time, body iron accumulation is associated with high risk of different morbidities.Purpose: We hypothesized that Nordic Walking training would result in pro-healthy changes in an elderly group of subjects by reducing body iron stores via shifts in iron metabolism-regulating proteins.Methods: Thirty-seven women aged 67.7±5.3 years participated in this study. They underwent 32 weeks of training, 1-hour sessions three times a week, between October 2012 and May 2013. Fitness level, blood morphology, CRP, vitamin D, ferritin, hepcidin, and soluble Hjv were assessed before and after the training.Results: The training program caused a significant decrease in ferritin, which serves as a good marker of body iron stores. Simultaneously, the physical cardiorespiratory fitness had improved. Furthermore, blood hepcidin was positively correlated with the ferritin concentration after the training. The concentration of blood CRP dropped, but the change was nonsignificant. The applied training

  11. An ex vivo RT-qPCR-based assay for human peripheral leukocyte responsiveness to glucocorticoids in surgically induced inflammation

    Directory of Open Access Journals (Sweden)

    Gråberg T

    2015-08-01

    Full Text Available Truls Gråberg,1 Lovisa Strömmer,1 Erik Hedman,2 Mehmet Uzunel,3 Ewa Ehrenborg,4 Ann-Charlotte Wikström5 1Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC, Karolinska Institutet, 2Department of Clinical Pharmacology, Karolinska University Hospital, 3Division of Therapeutic Immunology, Department of Laboratory Medicine, 4Atherosclerosis Research Unit, Department of Medicine, Solna, 5Unit of Translational Immunology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden Introduction: An assay to determine glucocorticoid (GC responsiveness in humans could be used to monitor GC non-responsiveness in states of GC insufficiency and could provide a tool to adapt GC treatment to individual patients. We propose an ex vivo assay to test GC responsiveness in peripheral leukocytes. The assay was evaluated in a human experimental model of surgery-induced inflammation. Patients and methods: Changes in expression of the GC-regulated genes GILZ, IL1R2, FKBP5, and HLA-DR and glucocorticoid receptor alpha (GRα were determined by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR in peripheral leukocytes from surgical patients and healthy blood donors (total n=60 in response to low (1 nM and high (1 µM dexamethasone (DEX. The final selection of a suitable endogenous control gene was based on the studies of stability during DEX treatment and inflammation. Correlations between pre- and postoperative GC-induced gene expression, the postoperative systemic inflammatory and metabolic response (CRP, IL-6, white blood cell count, cytokines, resistin, free fatty acids, glucose, insulin, and adiponectin, and the clinical outcome were analyzed. The length of stay in the intensive care unit (ICU-LOS, the length of stay in the hospital, and postoperative complications were used to measure clinical outcome. Results: When the blood donors were compared to the patients, there were no significant

  12. Comparison of different cell type correction methods for genome-scale epigenetics studies.

    Science.gov (United States)

    Kaushal, Akhilesh; Zhang, Hongmei; Karmaus, Wilfried J J; Ray, Meredith; Torres, Mylin A; Smith, Alicia K; Wang, Shu-Li

    2017-04-14

    Whole blood is frequently utilized in genome-wide association studies of DNA methylation patterns in relation to environmental exposures or clinical outcomes. These associations can be confounded by cellular heterogeneity. Algorithms have been developed to measure or adjust for this heterogeneity, and some have been compared in the literature. However, with new methods available, it is unknown whether the findings will be consistent, if not which method(s) perform better. Methods: We compared eight cell-type correction methods including the method in the minfi R package, the method by Houseman et al., the Removing unwanted variation (RUV) approach, the methods in FaST-LMM-EWASher, ReFACTor, RefFreeEWAS, and RefFreeCellMix R programs, along with one approach utilizing surrogate variables (SVAs). We first evaluated the association of DNA methylation at each CpG across the whole genome with prenatal arsenic exposure levels and with cancer status, adjusted for estimated cell-type information obtained from different methods. We then compared CpGs showing statistical significance from different approaches. For the methods implemented in minfi and proposed by Houseman et al., we utilized homogeneous data with composition of some blood cells available and compared them with the estimated cell compositions. Finally, for methods not explicitly estimating cell compositions, we evaluated their performance using simulated DNA methylation data with a set of latent variables representing "cell types". Results from the SVA-based method overall showed the highest agreement with all other methods except for FaST-LMM-EWASher. Using homogeneous data, minfi provided better estimations on cell types compared to the originally proposed method by Houseman et al. Further simulation studies on methods free of reference data revealed that SVA provided good sensitivities and specificities, RefFreeCellMix in general produced high sensitivities but specificities tended to be low when

  13. Physical and mental health aspects of elderly in social care in Poland

    Directory of Open Access Journals (Sweden)

    Dobrzyn-Matusiak D

    2014-10-01

    Full Text Available Dorota Dobrzyn-Matusiak,1 Czeslaw Marcisz,2 Ewelina Bąk,3 Halina Kulik,1 Ewa Marcisz4 1Department of Nursing Propaedeutics, 2Department of Gerontology and Geriatric Nursing, School of Health Care, Medical University of Silesia, Katowice, Poland; 3Faculty of Health Sciences, University of Bielsko-Biała, Bielsko-Biała, Poland; 4Department of Anxiety Disorders, Hospital of Ministry of Internal Affairs, Katowice, Poland Background: The objective of the study was to evaluate health aspects in elderly individuals in social, institutional, and home care in Poland.Methods: A total of 300 elderly individuals in care in Poland were included in the study. The subjects were divided into three groups: residents of long-term care institutions (group I, residents of adult day-care homes (group II, and community-dwelling subjects (group III. Each group consisted of 100 subjects. Questionnaires evaluating the following physical and mental dimensions of health were used: SF-36 Health Survey, basic activities of daily living, instrumental activities of daily living, Geriatric Depression Scale, and Mini–mental state examination.Results: It was found that the health aspects of the elderly varied depending on whether care was provided in an institutionalized or a home environment, and the lowest health status was found in the elderly receiving in-home care. Furthermore, home-based elderly indicated significant limitations in performing basic activities of daily living and instrumental activities of daily living, as well as a higher prevalence of depression and cognitive impairment.Conclusion: The elderly in long-term institutionalized care, both in a residential home and adult day-care homes, were characterized by a better physical and mental health status than those receiving in-home care. It seemed that worse health status, including the more frequent depression occurrence and cognitive function disorders in the elderly using the nursing care at their homes

  14. Eerder anders as elders: Gerrie Snyman se bydrae in die konteks van die Gereformeerde teologie

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    Hans J.M. van Deventer

    2010-03-01

    Full Text Available Rather different than elsewhere: Gerrie Snyman�s contribution in the context of Reformed theology Prof Gerrie Snyman�s book Om die Bybel anders te lees: �n etiek van Bybellees (2007 attracted considerable attention in Afrikaans-speaking reformed circles in South Africa. In this article, some of the responses to and reviews of the book are studied in order to assess the publication�s impact. Moreover, the article aims to determine whether the book will contribute to future reflections and discussions on the use of the Bible in this context. It is concluded that the preferred method of interpretation in the Reformed Church in South Africa calls for a thorough revision. The so-called �grammatical-historical method� of interpretation can no longer be regarded as the most appropriate and sole �Reformed method� of interpretation.�--- Abstract translated into Sipedi ---Go fapana le t�e dingwe: seabe sa Gerrie Snyman go teologie ya RefomoPuku ya Profesa Gerrie Snyman, Om die Bybel anders te lees: �n Etiek van Bybellees (2007, e gogile �edi ye kgolo ya maloko a kereke ya Refomo mo Afrika-Borwa(RCSA/GKSA. Mo pampiring ye re ithuta t�e dingwe t�a dikarabo le ditshekatsheko t�a puku ye go ela khuet�o ya yona. Go feta fao, pampiri ye e nepile go bona ge e ba puku ye e tlo ba le seabe go dikakanyo le dipoledi�ano mabapi le t�homi�o ya Beibele ditabeng t�a mohuta wo. Re ruma ka go re, mokgwa wa tshekatsheko ya Bibele wa Kereke ya Refomo mo Afrika-Borwa o hloka go lekodi�i�wa le go boelet�wa. Mokgwa wa go hlatholla Bibele ka go sekaseka popopolelo(gramatika le histori ya tlholego ya yona, o ka se sa t�ewa e le wona wa maleba o nno�i wa tshekatsheko goba go ba wona �Mokgwa wa Refomo� wa go fetleka Bibele.--- End of translation ---

  15. Association between sensory function and hop performance and self-reported outcomes in patients with anterior cruciate ligament injury

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    Cronström A

    2017-01-01

    Full Text Available Anna Cronström,1 Ewa M Roos,2 Eva Ageberg1 1Department of Health Sciences, Lund University, Lund, Sweden; 2Research Unit for Musculoskeletal Function and Physiotherapy, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark Background: In patients with anterior cruciate ligament (ACL deficiency (ACLD or reconstruction (ACLR, sensory deficits are commonly assessed as knee kinesthesia using time-consuming laboratory equipment. Portable equipment such as that used for evaluation of vibration sense would be preferable. In contrast to kinesthesia, vibration sense is not well studied in these patients. Objectives: 1 To study the association between kinesthesia and vibration sense to investigate if one sensory measurement can replace the other; and 2 to determine the clinical relevance by investigating associations between the sensory measurements and functional performance and patient-reported outcomes in patients with ACLD or ACLR. Methods: Twenty patients with ACLD and 33 patients with ACLR were assessed with knee kinesthesia, vibration sense, the one-leg hop test for distance, as well as the Knee injury and Osteoarthritis Outcome Score (KOOS and the Tegner Activity Scale. Results: There were no significant correlations between kinesthesia and vibration sense (r= –0.267, p>0.269 or between the sensory measures and hop performance (r= –0.351, p>0.199. In patients with ACLD, worse knee kinesthesia was associated with worse scores on KOOS subscales pain (r= –0.464, p=0.046 and activities of daily living (r= –0.491, p=0.033, and worse vibration sense was associated with worse scores on KOOS subscale quality of life (r= –0.469, p=0.037 and worse knee confidence (item Q3 from subscale quality of life (rs=0.436, p=0.054. In patients with ACLR, worse vibration sense was associated with worse scores on KOOS subscales pain (r= –0.402, p=0.020 and activities of daily living (r= –0.385, p=0

  16. Co-nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: in vitro evaluation of cytotoxicity and magnetohyperthermia efficacy

    Directory of Open Access Journals (Sweden)

    Estevanato LC

    2012-10-01

    Full Text Available Luciana LC Estevanato,1 Jaqueline R Da Silva,1 André M Falqueiro,2 Ewa Mosiniewicz-Szablewska,3 Piotr Suchocki,4,5 Antônio C Tedesco,2 Paulo C Morais,6 Zulmira GM Lacava11Instituto de Ciências Biológicas, Universidade de Brasília, Brasília DF, Brazil; 2Departamento de Química, Laboratório de Fotobiologia e Fotomedicina, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto SP, Brazil; 3Institute of Physics, Polish Academy of Sciences, Warsaw, Poland; 4Department of Drug Analysis, Warsaw Medical University, Warsaw, Poland; 5Department of Pharmaceutical Chemistry, National Medicines Institute, Warsaw, Poland; 6Instituto de Física, Universidade de Brasília, Brasília DF, BrazilAbstract: Antitumor activities have been described in selol, a hydrophobic mixture of molecules containing selenium in their structure, and also in maghemite magnetic nanoparticles (MNPs. Both selol and MNPs were co-encapsulated within poly(lactic-co-glycolic acid (PLGA nanocapsules for therapeutic purposes. The PLGA-nanocapsules loaded with MNPs and selol were labeled MSE-NC and characterized by transmission and scanning electron microscopy, electrophoretic mobility, photon correlation spectroscopy, presenting a monodisperse profile, and positive charge. The antitumor effect of MSE-NC was evaluated using normal (MCF-10A and neoplastic (4T1 and MCF-7 breast cell lines. Nanocapsules containing only MNPs or selol were used as control. MTT assay showed that the cytotoxicity induced by MSE-NC was dose and time dependent. Normal cells were less affected than tumor cells. Cell death occurred mainly by apoptosis. Further exposure of MSE-NC treated neoplastic breast cells to an alternating magnetic field increased the antitumor effect of MSE-NC. It was concluded that selol-loaded magnetic PLGA-nanocapsules (MSE-NC represent an effective magnetic material platform to promote magnetohyperthermia and thus a potential system

  17. Comparative analysis of the expected demands for nursing care services among older people from urban, rural, and institutional environments

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    Borowiak E

    2015-02-01

    Full Text Available Ewa Borowiak,1,2,* Joanna Kostka,3,* Tomasz Kostka1 1Department of Geriatrics, Medical University of Lodz, Poland; 2Institute of Nursing, Medical University of Lodz, Poland; 3Department of Physical Medicine, Medical University of Lodz, Poland *These authors contributed equally to this work Background: Demand for nursing and social services may vary depending on the socio-demographic variables, health status, receipt of formal and informal care provided, and place of residence. Objectives: To conduct a comparative analysis of the expectations of older people from urban, rural, and institutional environments concerning nursing care with respect to the care provided and elements of a comprehensive geriatric assessment. Material and methods: The study comprised 2,627 individuals above the age of 65 years living in urban (n=935 and rural (n=812 areas as well as nursing homes (n=880. Results: Family care was most often expected both in urban (56.6% and rural (54.7% environments, followed by care provided simultaneously by a family and nurse (urban – 18.8%; rural – 26.1% and realized only by a nurse (urban – 24.6%; rural – 19.2%. Not surprisingly, nursing home residents most commonly expected nursing care (57.5% but 33.1% preferred care provided by family or friends and neighbors. In the whole cohort of people living in the home environment (n=1,718, those living with family demonstrated willingness to use primarily care implemented by the family (62.0%, while respondents living alone more often expected nursing services (30.3%. In the logistic regression model, among the respondents living in the city, only the form of care already received determined the expectations for nursing care. Among the respondents living in the county, the presence of musculoskeletal disorders, better nutritional status, and current care provided by family decreased expectations for nursing care. Higher cognitive functioning, symptoms of depression, and living alone

  18. Toxicity of pristine graphene in experiments in a chicken embryo model

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    Sawosz E

    2014-08-01

    Full Text Available Ewa Sawosz,1 Slawomir Jaworski,1 Marta Kutwin,1 Anna Hotowy,1 Mateusz Wierzbicki,1 Marta Grodzik,1 Natalia Kurantowicz,1 Barbara Strojny,1 Ludwika Lipinska,2 André Chwalibog3 1Division of Nanobiotechnology, Warsaw University of Life Sciences, Warsaw, Poland; 2Institute of Electronic Materials Technology, Warsaw, Poland; 3Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark Abstract: Evaluation of the potential cytotoxicity of graphene is a key factor for medical applications, where flakes or a surface of graphene may be used as bioactive molecules, drug carriers, or biosensors. In the present work, effects of pristine graphene (pG on the development of a living organism, with an emphasis on morphological and molecular states of the brain, were investigated using a chicken embryo model. Fertilized chicken eggs were divided into the control group and groups administered with pG suspended in milli-Q water at concentrations of 50 µg/L, 100 µg/L, 500 µg/L, 1,000 µg/L, 5,000 µg/L, and 10,000 µg/L (n=30 per group. The experimental solutions were injected in ovo into the albumin and then the eggs were incubated. After 19 days of incubation, the survival, weight of the body and organs, and blood serum biochemical indices were measured. The brain samples were collected for microscopic examination of brain ultrastructure and measurements of gene and protein expression. Survival of embryos was significantly decreased after treatment with pG, but the body and organ weights as well as biochemical indices were not affected. In all treatment groups, some atypical ultrastructures of the brain were observed, but they were not enhanced by the increasing concentrations of pG. Expression of proliferating cell nuclear antigen at the messenger ribonucleic acid level was downregulated, and the number of proliferating cell nuclear antigen-positive nuclei was significantly reduced in the 500–10,000 µg

  19. Editorial

    Directory of Open Access Journals (Sweden)

    Mirosław Pawlak

    2011-08-01

    Full Text Available The current issue of Studies in Second Language Learning and Teaching brings together six contributions written by scholars from Poland and abroad which deal with a wide array of issues related to learning and teaching additional languages in different educational contexts. First, Weronika Szubko-Sitarek reports the findings of two experimental studies conducted within the lexical decision task paradigm which aimed to investigate the cognate facilitation effect in the process of recognizing words in a third language by Polish unbalanced trilinguals who, in addition to their mother tongue, were proficient in English and had variable command of German. In the next paper, Sane M. Yagi and Saleh Al-Salman make a strong case for the use of tracking software in writing pedagogy as a tool for providing invaluable insights into the process of composing texts, but also a method of stimulating reflection and promoting strategic learning. The research-based contributions by Ewa Waniek-Klimczak and Aleksandra Wach, in turn, shift the emphasis to sociolinguistic issues. The former presents the findings of a qualitative study which examined the acculturation patterns of three recent Polish immigrants to the United Kingdom, who were expert users of English, in relation to their formal and informal language learning experiences, while the latter uses questionnaire data obtained from a respectable sample of Polish-speaking English majors to shed light on their preferences concerning pronunciation norms based on the native-speaker model and the Lingua Franca Core. The last two papers included in this issue report the findings of studies exploring the role of anxiety in learning foreign language skills and subsystems. In the first of these, Christina Gkonou examines the interfaces between speaking and writing anxiety manifested by Greek learners of English as a foreign language in a private school setting and, in the second, Magdalena Szyszka taps the relationship

  20. 新能源汽车市场开拓的政府补贴机制研究%The Government Subsidies Mechanism for Market Development of New Energy Vehicle

    Institute of Scientific and Technical Information of China (English)

    张海斌; 盛昭瀚; 孟庆峰

    2015-01-01

    With the increasing concern over the issues of resources demand and ecological environment, new energy vehicle has become the unavoidable tendency of vehicle development for a long time.The development of new energy vehicle, which provides a good answer to the resource and environment challenge, has been included as an indispensable part in national strategy in Chi-na.Among others, market cultivation is one important question in its development.How to take the full advantage of government subsidy to promote the sale aspiration and service quality of the sales enterprises has become the central issue, which deserves wide attention. In this paper, the Multi-Agent method has been employed to build a model, by which we explored the question that how the serv-ice quality of the sales enterprise with behavior externality can be encouraged with the government subsidy.With this model, we investigated the impact of factors such as government subsidizing strength and selling objective that is qualified to acquire subsidy on the relevant performance of system.What is more, the EWA algorithm was also introduced to the decision-making mechanism on government subsidizing strength, after which we explored the differences on the relevant performance of the system, when the two incentive mode were used, that is, the static incentive mode with constant subsidizing strength and the dynamic incentive mode with subsidizing strength depending on EWA algorithm. It is demonstrated that the consumer demand for the new energy vehicle must be surveyed and analyzed, based which results the government formulate corresponding plan for market expansion.In addition, the positive influence of the selling objective on mar-ket development is also revealed.But, appropriate principle is necessary when designing the policy whether a selling objective is qualified to get the subsidy or not, whereby the combination of multiple strategies are preferred to encourage the sale of enterpri-ses.It is also

  1. A comparative study of internal laser-assisted and conventional liposuction: a look at the influence of drugs and major surgery on laboratory postoperative values

    Directory of Open Access Journals (Sweden)

    Przylipiak AF

    2013-10-01

    Full Text Available Andrzej Feliks Przylipiak,1 Elżbieta Galicka,1 Magdalena Donejko,1 Marek Niczyporuk,1 Jerzy Przylipiak21Department of Aesthetic Medicine, Faculty of Pharmacy, Medical University of Bialystok, Bialystok, Poland; 2Medical Office, Bialystok, PolandBackground: Liposuction is a type of aesthetic surgery that has been performed on humans for decades. There is not much literature addressing the subject matter of pre- and post-surgery blood parameters, although this information is rather interesting. Documentation on patients who received laser-assisted liposuction treatment is particularly scarce. Until now, there has been no literature showing values of platelets, lymphocytes, and neutrophils after liposuction.Purpose: The aim of the work is to analyze and interpret values of platelets, lymphocytes and neutrophils in patient blood before and after liposuction, a surgery in which an extraordinarily large amount of potent drugs are used. Moreover, the aim is to compare values changes in patients of conventional and laser-assisted liposuction.Material and methods: We evaluated standard blood samples in patients prior to and after liposuction. This paper covers the number of platelets, lymphocytes, and neutrophils. A total of 54 patients were examined. Moreover, we compared the change in postoperative values in laser-assisted liposuction patients with the change of values in conventional liposuction patients. A paired two-sided Student's t-test was used for statistical evaluation. P < 0.005 was acknowledged to be statistically significant.Results: Values of platelets were raised both in conventional and in laser-assisted liposuction patients, but this difference was statistically non-significant and levels of platelets were still normal and within the range of blood levels in healthy patients. Values of neutrophils rose by up to 79.49% ± 7.74% standard deviation (SD and values of lymphocytes dropped by up to 12.68% ± 5.61% SD. The before

  2. PREFACE: DISCRETE 2012 - Third Symposium on Prospects in the Physics of Discrete Symmetries

    Science.gov (United States)

    Branco, G. C.; Emmanuel-Costa, D.; González Felipe, R.; Joaquim, F. R.; Lavoura, L.; Palomares-Ruiz, S.; Rebelo, M. N.; Romão, J. C.; Silva, J. P.

    2013-07-01

    Romão, J P Silva and J I Silva-Marcos International Advisory CommitteeLocal Organising Committee Francisco del Águila (Granada)From CFTP Jose Bernabéu (Valencia) Francisco Botella (Valencia)G C Branco Andrzej Buras (Munich)D Emmanuel-Costa Marcos Cerrada (Madrid)R González Felipe Pierluigi Campana (CERN)F R Joaquim Antonio Di Domenico (Rome)L Lavoura John Ellis (CERN)S Palomares-Ruiz Fernando Ferroni (Rome)M N Rebelo Luis Garrido (Barcelona)J C Romão Marcello Giorgi (Pisa)J P Silva Neville Harnew (Oxford)J I Silva-Marcos Maria José Herrero (Madrid) David Hitlin (Caltech)From LIP Gino Isidori (Frascati) Guido Martinelli (Rome)G Barreira Antonio Masiero (Padua)J Varela Nickolaos Mavromatos (London) Vasiliki Mitsou (Valencia) Hitoshi Murayama (Berkeley) Tatsuya Nakada (Lausanne) Antonio Pich (Valencia) Apostolos Pilaftsis (Manchester) Stefan Pokorski (Warsaw) Fabio Zwirner (Padua) Secretariat Dulce Conceição Sandra Oliveira Cláudia Romão discrete2012@cftp.ist.utl.pt http://indico.cern.ch/event/discrete2012 Sponsors CFTP - Centro de Física Teórica de Partículas LIP - Laboratório de Instrumentação e Física Experimental de Partículas IST - Instituto Superior Técnico FCT - Fundação para a Ciência e a Tecnologia Group picture The PDF also contains the conference poster and a list of participants.

  3. WE-A-201-02: Modern Statistical Modeling.

    Science.gov (United States)

    Niemierko, A

    2016-06-01

    Commission and may be remembered for his critique of the National Academy of Sciences BEIR III report (stating that their methodology "imposes a Delphic quality to the .. risk estimates".) This led to his appointment as a member of the BEIR V committee. Don presented refresher courses at the AAPM, ASTRO and RSNA meetings and was active in the AAPM as a member or chair of several committees. He was the principal author of AAPM Report 43, which is essentially a critique of established clinical studies prior to 1992. He was co-editor of the Proceedings of many symposia on Time, Dose and Fractionation held in Madison, Wisconsin. He received the AAPM lifetime Achievement award in 2004. Don's second wife of 46 years, Ann, predeceased him and he is survived by daughters Hillary and Emily, son John and two grandsons. Don was a true gentleman with a unique and erudite writing style illuminated by pithy quotations. If he had a fault it was, perhaps, that he did not realize how much smarter he was than the rest of us. This presentation draws heavily on a biography and video interview in the History and Heritage section of the AAPM website. The quote is his own. Andrzej Niemierko: Statistical modeling plays an essential role in modern medicine for quantitative evaluation of the effect of treatment. This session will feature an overview of statistical modeling techniques used for analyzing the many types of research data and an exploration of recent advances in new statistical modeling methodologies.

  4. WE-A-201-00: Anne and Donald Herbert Distinguished Lectureship On Modern Statistical Modeling.

    Science.gov (United States)

    Deasy, Joseph

    2016-06-01

    Commission and may be remembered for his critique of the National Academy of Sciences BEIR III report (stating that their methodology "imposes a Delphic quality to the .. risk estimates".) This led to his appointment as a member of the BEIR V committee. Don presented refresher courses at the AAPM, ASTRO and RSNA meetings and was active in the AAPM as a member or chair of several committees. He was the principal author of AAPM Report 43, which is essentially a critique of established clinical studies prior to 1992. He was co-editor of the Proceedings of many symposia on Time, Dose and Fractionation held in Madison, Wisconsin. He received the AAPM lifetime Achievement award in 2004. Don's second wife of 46 years, Ann, predeceased him and he is survived by daughters Hillary and Emily, son John and two grandsons. Don was a true gentleman with a unique and erudite writing style illuminated by pithy quotations. If he had a fault it was, perhaps, that he did not realize how much smarter he was than the rest of us. This presentation draws heavily on a biography and video interview in the History and Heritage section of the AAPM website. The quote is his own. Andrzej Niemierko: Statistical modeling plays an essential role in modern medicine for quantitative evaluation of the effect of treatment. This session will feature an overview of statistical modeling techniques used for analyzing the many types of research data and an exploration of recent advances in new statistical modeling methodologies.

  5. Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry

    Directory of Open Access Journals (Sweden)

    Brola W

    2016-08-01

    Full Text Available Waldemar Brola,1 Piotr Sobolewski,2 Małgorzata Fudala,1 Stanisław Flaga,3 Konrad Jantarski,4 Danuta Ryglewicz,5 Andrzej Potemkowski6 1Department of Neurology, Specialist Hospital, Końskie, 2Department of Neurology, Holy Spirit Specialist Hospital, Sandomierz, 3AGH University of Science and Technology, Krakow, 4Swietokrzyski Regional Branch of the Polish National Health Fund (NFZ, Kielce, 5First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, 6Department of Psychology, University of Szczecin, Szczecin, Poland Background: The aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL of multiple sclerosis (MS patients registered in the Polish MS Registry.Methods: This was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale. Univariate analysis and logistic regression were performed to determine the factors associated with QoL.Results: The study included 2,385 patients (female/male ratio 2.3:1 with clinically confirmed MS (mean age 37.8±9.2 years. Average EuroQol 5-Dimensions index was 0.72±0.24, and the mean EuroQoL Visual Analog Scale score was 64.2±22.8. The average Multiple Sclerosis Impact Scale score was 84.6±11.2 (62.2±18.4 for physical condition and 23.8±7.2 for mental condition. Lower QoL scores were significantly associated with higher level of disability (odds ratio [OR], 0.932; 95% confidence interval [CI], 0.876–0.984; P=0.001, age >40 years (OR, 1.042; 95% CI, 0.924–1.158; P=0.012, longer disease duration (OR, 0.482; 95% CI, 0.224–0.998; P=0

  6. PREFACE: 10th Summer School on Theoretical Physics 'Symmetry and Structural Properties of Condensed Matter'

    Science.gov (United States)

    Lulek, Tadeusz; Wal, Andrzej; Lulek, Barbara

    2010-03-01

    also for several valuable discussion. We would like to express our thanks to all those who prepared manuscripts, to all referees who spent their time to significantly improve our elaborations, and thus the quality of this volume, to all members of our International Advisory Committee and to chairmen for their polite and efficient leading of sessions. It is our pleasure to express special gratitude to The Nicolas C Metropolis Mathematics Foundation (Los Alamos, USA) for substantial financial support of our three last SSPCM schools. Indeed, it provided an essential basis for performing these meetings. We direct this gratitude to Professor James D Louck, the President of this Foundation. Also, we were happy to hear from Professor Louck that this series of schools has had an important influence on his activities on application of unitary groups in physics. It has resulted in a new monograph: James D Louck, 'Unitary Symmetry and Combinatorics', World Scientific, New Jersey 2008, which was presented at our jubilee meeting. Tadeusz Lulek, Andrzej Wal and Barbara Lulek

  7. Faculty of social Christian teaching at Jagiellonian University

    Directory of Open Access Journals (Sweden)

    Stanisław Piech

    1989-12-01

    Vorlesungen Andrzej Mytkowicz, ein Geistlicher und ehemaliger Universitatsprofessor fur christliche Soziologie in Lemberg, der sie bis 1938/39 fortsetzte. Zur Zeit der deutschen Besatzung, als die Krakauer Universitat bereits geschlossen war, wurde die Katcholische Soziallehre an den Priesterseminaren den Priesterseminaren fur die Diozese Krakau und Tschenstochau von Piwowarczyk unterrichtet. Nach Kriegsende ubernahm den Lehrauftrag an der JU wieder Mytkowicz und las daruber bis 1946/47. Von 1947 bis 1952 setzte diese Vortragsreihe Piwowarczyk fort, der zu dem Zeitpunkt auch Redaktionsmitglied der katholischen Wochenschrift "Tygodnik Powszechny" war. In dem Studienjahr 1952/53 wurde Piwowarczyk von Bolesław Kominek, dem spateren Kardinal und Erzbischof-Metropolit von Wrocław abgelost. Im letzten Jahr vor der Abschaffung der Theologischen Fakultat an der UJ hielt diese Vortrage Karol Wojtyła, der spatere Krakauer Erzbischof und Papst Johannes-Paul II. Obgleich in dem Zeitraum 1910-1954 die Katholische Soziallehre an der UJ nur 15 Oahre lang an einen eigens dafur eingerichteten Lehrstuhl unterrichtet werden konnte, hatte die Theologische Fakultat das Gluck, dafur jeweils die besten Wissenschaftler zu gewinnen, die - wie Zimmermann, Piwowarczyk und nicht zuletzt auch Karol Wojtyła - bis heute sehr bekannt sind.

  8. Influence of core design, production technique, and material selection on fracture behavior of yttria-stabilized tetragonal zirconia polycrystal fixed dental prostheses produced using different multilayer techniques: split-file, over-pressing, and manually built-up veneers

    Directory of Open Access Journals (Sweden)

    Mahmood DJH

    2016-02-01

    Full Text Available Deyar Jallal Hadi Mahmood, Ewa H Linderoth, Ann Wennerberg, Per Vult Von Steyern Department of Prosthetic Dentistry, Faculty of Odontology, Malmö University, Malmö, Sweden Aim: To investigate and compare the fracture strength and fracture mode in eleven groups of currently, the most commonly used multilayer three-unit all-ceramic yttria-stabilized tetragonal zirconia polycrystal (Y-TZP fixed dental prostheses (FDPs with respect to the choice of core material, veneering material area, manufacturing technique, design of connectors, and radii of curvature of FDP cores. Materials and methods: A total of 110 three-unit Y-TZP FDP cores with one intermediate pontic were made. The FDP cores in groups 1–7 were made with a split-file design, veneered with manually built-up porcelain, computer-aided design-on veneers, and over-pressed veneers. Groups 8–11 consisted of FDPs with a state-of-the-art design, veneered with manually built-up porcelain. All the FDP cores were subjected to simulated aging and finally loaded to fracture. Results: There was a significant difference (P<0.05 between the core designs, but not between the different types of Y-TZP materials. The split-file designs with VITABLOCS® (1,806±165 N and e.max® ZirPress (1,854±115 N and the state-of-the-art design with VITA VM® 9 (1,849±150 N demonstrated the highest mean fracture values. Conclusion: The shape of a split-file designed all-ceramic reconstruction calls for a different dimension protocol, compared to traditionally shaped ones, as the split-file design leads to sharp approximal indentations acting as fractural impressions, thus decreasing the overall strength. The design of a framework is a crucial factor for the load bearing capacity of an all-ceramic FDP. The state-of-the-art design is preferable since the split-file designed cores call for a cross-sectional connector area at least 42% larger, to have the same load bearing capacity as the state-of-the-art designed

  9. In vitro Tracheobronchial Relaxation of Fritillaria Alkaloids%贝母生物碱的体外气管松弛作用研究

    Institute of Scientific and Technical Information of China (English)

    陈舜宏; 李萍; 关耀华; 林鸽

    2011-01-01

    AIM:Beimu(Bulbus Fritillariae)is a commonly used anti-tussive traditional Chinese herbal medicine and the major Fritillaria alkaloids in the herb are believed to be responsible for its antitussive activity.However,the detailed underlying mechanism and potency of individual Fritillaria alkaloids are still not very clear.METHODS:In the present study,we investigated and compared the relaxant effect of five major Fritillaria alkaloids[imperialine(IMP),verticine(VER),verticinone(VERN),ebeiedine(EBE)and puqietinone(PUQ)]using rat isolated tracheal and bronchial preparations pre-contracted with carbachol.RESULTS:All five Fritillaria alkaloids caused a concentration-dependent relaxation of both tracheal and bronchial preparations with the relative relaxing potency of IMP>VER≌VERN>EBE>PUQ.Amongst all five alkaloids tested,IMP(an isosteroidal Fritillaria alkaloid with a cis-configuration in rings D and E)was found to be the most potent;whereas PUQ(a steroidal Fritillaria alkaloid)was the least effective one.Furthermore,three Fritillaria alkaloids,namely IMP,VER and VERN(≥1 μmol-L-1)were capable of eliciting parallel rightward shifts of the carbachol concentration-response curve,demonstrating a competitive antagonism in muscarinic pathway.In addition,the suppression of carbachol-induced contraction caused by all five isosteroidal Fritillaria alkaloids was also partly due to the inhibition of influx of calcium ions.CONCLUSION:The results demonstrated that the major isosteroidal Fritillaria alkaloids might be the most active constituents responsible for the anti-tussive activity of herbal Beimu with the mechanisms of competitive antagonism of muscarinic pathway and also the inhibition of influx of calcium ions.%目的:贝母是一种常用的传统止咳中药,贝母生物碱被认为是其镇咳的主要活性成分,但其作用机理和各种生物碱的作用强度仍然不是很明确.方法:选用离体大鼠气管和支气管作为体外模型并用卡巴胆

  10. Health locus of control and the sense of self-efficacy in patients with systolic heart failure: a pilot study

    Directory of Open Access Journals (Sweden)

    Rydlewska A

    2013-04-01

    Full Text Available Agnieszka Rydlewska,1,2 Justyna Krzysztofik,3 Julia Libergal,3 Agata Rybak,3 Waldemar Banasiak,1 Piotr Ponikowski,1,2 Ewa A Jankowska1,21Centre for Heart Diseases, Department of Cardiology, Military Hospital, Wroclaw, Poland; 2Department of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland; 3Student’s Scientific Organization, Laboratory for Applied Research on Cardiovascular System, Wroclaw Medical University, Wroclaw, PolandBackground: Treatment of heart failure (HF requires the lifelong adherence to medical self-care regimes. The objective of this study was to examine health-control beliefs and the sense of self-efficacy (psychological features particularly important for efficient compliance among patients suffering from chronic diseases in patients with systolic HF in relation to clinical status and depressive symptoms.Subjects and methods: Sixty-six consecutive patients with chronic systolic HF, hospitalized in the Centre for Heart Diseases, Military Hospital (94% men, age: 61 ± 11 years, ischemic etiology: 63%, left ventricular ejection fraction: 32% ± 12%, filled in (during their hospital stay: (1 the Multidimensional Health Locus of Control Scale measuring three possible localizations of health control: “internality” (ie, the belief that health status depends only on personal decisions and behaviors; “powerful others externality” ([PHLC subscale] ie, the conviction that health depends on “powerful people” such as doctors, family members, close friends, and “chance externality” (ie, belief that health status is determined by chance, fate, or luck, and (2 the Generalized Self-Efficacy Scale. The results obtained by HF patients were compared to those reported by patients with other chronic diseases and healthy subjects.Results: In patients with HF, internality was similar to values obtained by patients with diabetes, men after myocardial infarction, and women after mastectomy; and was lower than in healthy

  11. PLASMA-2013: International Conference on Research and Applications of Plasmas (Warsaw, Poland, 2-6 September 2013)

    Science.gov (United States)

    Sadowski, Marek J.

    2014-05-01

    , Otwock, Poland—Chairman Dimitri Batani, Universite Bordeaux, France Sergio Ciattaglia, ITER, Cadarache, France Michael Dudeck, UPMC, Paris, France Igor E Garkusha, NSC KIPT, Kharkov, Ukraine Zbigniew Kłos, CBK PAN, Warsaw Giorgio Maddaluno, ENEA Frascati, Italy Andrea Murari, EFDA JET, Culham, UK Józef Musielok, University of Opole, Poland Svetlana Ratynskaia, RIT, Stockholm, Sweden Karel Rohlena, IP CAS, Prague, Czech Republic Valentin Smirnov, Rosatom, Moscow, Russia Francisco Tabares, CIEMAT, Madrid, Spain Lorenzo Torrisi, University of Messina, Messina, Italy Jerzy Wołowski, IFPiLM, Warsaw, Poland Urszula Woźnicka, IFJ PAN, Cracow, Poland Local Organizing Committee Jerzy Wołowski—Chairman Paweł Gąsior—Secretary Zofia Kalinowska Ewa Kowalska-Strzęciwilk Monika Kubkowska Anita Pokorska Ryszard Panfil Joanna Dziak-Beme Conference website: http://plasma2013.ipplm.pl/

  12. Age influence on renalase and catecholamines concentration in hypertensive patients, including maintained dialysis

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    Zbroch E

    2016-10-01

    Full Text Available Edyta Zbroch, Dominika Musialowska, Ewa Koc-Zorawska, Jolanta Malyszko Second Department of Nephrology and Hypertension with Dialysis Centre, Medical University of Bialystok, Bialystok, Poland Background: Hypertension in elderly patients is one of the main problems in cardiovascular diseases. The sympathetic nervous system hyperactivity seen in older patients is a known risk factor for hypertension and other cardiovascular events as well as chronic kidney disease. Renalase, secreted by the kidney and circulated in blood, may regulate the sympathetic tone by catecholamine degradation and in this way has an impact on cardiovascular and renal complications.Objective: To assess the impact of age on renalase and catecholamine concentration in hypertensive patients, including those on dialyses and its possible relation to blood pressure control and cardiovascular disease.Methods: The study cohort of 211 patients was divided into two groups according to age below 65 years (range 19–64 and above 65 years (range 65–86. The older group represented 38% of the whole studied population and 75% of them were dialyzed. The two groups of different ages were also divided into dialysis and nondialysis subgroups. The serum renalase, dopamine, and norepinephrine concentration together with blood pressure value and echocardiography were assessed.Results: Patients aged 65 years and more had higher renalase (20.59 vs 13.14 µg/mL, P=0.02 and dopamine (41.71 vs 15.46 pg/mL, P<0.001 concentration as well as lower diastolic blood pressure (75.33 vs 85 mmHg, P=0.001, advanced abnormalities in echocardiography, and more often suffered from diabetes and coronary artery disease. The significant correlation between age and renalase (r=0.16; P=0.019, norepinephrine (r=0.179; P=0.013, and dopamine (r=0.21; P=0.003 was found in the whole study population. In the nondialysis subgroup, 44% had chronic kidney disease, mostly in the stage 2 (83%. There was a significantly higher

  13. Do prescrito ao real: a gestão individual e coletiva dos trabalhadores de enfermagem frente ao risco de acidente de trabalho From prescribed to real: the collective and individual management of nursing workers toward the risk of workplace accidents

    Directory of Open Access Journals (Sweden)

    Davidson Passos Mendes

    2012-12-01

    Full Text Available Esse artigo tem por objetivo levantar os constrangimentos enfrentados pelos auxiliares e técnicos de enfermagem (AeTE de uma instituição pediátrica, vinculada a uma fundação estatal, em sua atividade de trabalho e identificar estratégias utilizadas por eles que garantam as metas de produção, a satisfação do trabalhador e a sua autoproteção contra os acidentes de trabalho. Por meio do método da AET, foram utilizados para análise e coleta de dados 34 trabalhadores de enfermagem - nível médio e técnico -, entre efetivos e contratados e, observadas as estratégias de ação e regulação destes trabalhadores frente às interfaces com que lidam. Os resultados mostram que entre os constrangimentos levantados nesta Instituição, os mais evidentes são: a dupla jornada de trabalho, a diversidade de vínculos empregatícios, os riscos a que estes profissionais estão expostos e o não conhecimento do objeto de trabalho. Verifica-se que esses constrangimentos ocasionam uma elevação das cargas de trabalho física, psíquica e cognitiva. Visando reduzir essas cargas de trabalho, o trabalhador tenta criar estratégias que são adquiridas por meio da vivência com o trabalho, das experiências e valores, para se regular frente ao risco no trabalho.The objective of this study is to analyze the constraints faced by the nursing assistants and technicians in a pediatric clinic sponsored by a state foundation during their work activities and identify the strategies adopted by them in order to guarantee the achievement of their production goals and job satisfaction and ensure their protection against workplace accidents. The method of Ergonomic Work Analysis (EWA was used for analysis and data collection of 59 tenured and temporary nursing workers with intermediate and technical level of education and to investigate the strategies related to actions and employment regulation concerning the interfaces they deal with. The results show that among

  14. Cost-effective therapeutic hypothermia treatment device for hypoxic ischemic encephalopathy

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    Allen RH

    2013-01-01

    Full Text Available John J Kim,1,2 Nathan Buchbinder,1,† Simon Ammanuel,1,4,5,† Robert Kim,1,† Erika Moore,1 Neil O'Donnell,1 Jennifer K Lee,3 Ewa Kulikowicz,3 Soumyadipta Acharya,1 Robert H Allen,1,9 Ryan W Lee,6,7 Michael V Johnston4–81Department of Biomedical Engineering, Whiting School of Engineering, The Johns Hopkins University, 2The James Buchanan Brady Urological Institute, Department of Urology, The Johns Hopkins University School of Medicine, 3Department of Anesthesia and Critical Care Medicine, Johns Hopkins University, 4Kennedy Krieger Institute, 5Hugo W Moser Research Institute, 6Department of Neurology, 7Department of Pediatrics, 8Department of Physical Medicine and Rehabilitation Johns Hopkins University School of Medicine, Baltimore, MD; 9Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA†These authors contributed equally to this workAbstract: Despite recent advances in neonatal care and monitoring, asphyxia globally accounts for 23% of the 4 million annual deaths of newborns, and leads to hypoxic-ischemic encephalopathy (HIE. Occurring in five of 1000 live-born infants globally and even more in developing countries, HIE is a serious problem that causes death in 25%–50% of affected neonates and neurological disability to at least 25% of survivors. In order to prevent the damage caused by HIE, our invention provides an effective whole-body cooling of the neonates by utilizing evaporation and an endothermic reaction. Our device is composed of basic electronics, clay pots, sand, and urea-based instant cold pack powder. A larger clay pot, lined with nearly 5 cm of sand, contains a smaller pot, where the neonate will be placed for therapeutic treatment. When the sand is mixed with instant cold pack urea powder and wetted with water, the device can extract heat from inside to outside and maintain the inner pot at 17°C for more than 24 hours with monitoring by LED lights and thermistors

  15. Analyses of surface and groundwater flow characteristics of the Ljubljana moor and water resources vulnerability to climate and land use change and groundwater overdraft

    Science.gov (United States)

    Globevnik, Lidija; Bracic Zeleznik, Branka

    2016-04-01

    have prepared two land use changes scenarios for the I\\vska river catchment as an input data to model "swbEWA" (soil water balance for European Water Accounting) developed at European Environment Agency (Kurnik et al.,2014). In that model one climate scenario represents low impact to soil moisture and water balance (model 1), the other high impact (model 2). The modeling results show that there will be 20% lower annual runoff and 45% lower autumn and spring runoff under climatic model 2. Upper soil layer will have 35% less water on annual bases (drop in all months). Between October and February, the discharge of the I\\vska River will be lower for 24%, and 13% lower in the rest of the year. Groundwater level will drop in average for 40 cm on Ljubljana moor and 25 cm in the I\\vska river gravel fan. Recharge of groundwater in lower zones will drop for 18 % on average if the present pumping practice continues. We may expect reduction of available water resources for drinking water supply, larger drainage of wetland and significant subsidence of the aquifer.

  16. Motivating multi-retailers sales efforts considering external effects%考虑行为外部性的多零售商销售努力激励

    Institute of Scientific and Technical Information of China (English)

    孟庆峰; 盛昭瀚; 陈敬贤; 李真

    2014-01-01

    This paper builds a computational experiment model in which the manufacturer encourages the group of retailers to increase sale efforts using sales rebate and penalty contracts. We assumed that the retailers have fairness preference and study the impact of external effects among retailers on the incentive effects. The EWA algorithm is applied to the process of the manufacturer adjusting the incentives and penalties dynamically to maximize her own benefits. The aim of this paper is to provide suggestions to manufacturers to make rewards and punishments and use the external effects among retailers reasonably in multi-cycle periods. The results show that:the manufacturer should take measures to minimize the retailers“free rider”behavior,but not to e-liminate this behavior completely;the dynamic incentives will be better than the static incentives in multi-cycle incentive periods. Dynamic adjustment of rewards and punishments will greatly affect the level of the average sales efforts of retailers who have been motivated,but cannot affect the evolution trends of sales efforts of re-tailers who have been punished.%构建了制造商通过销售回馈与惩罚契约来对具有公平偏好的零售商群体的销售努力进行激励的计算实验模型。研究了零售商之间的行为外部性对激励效果产生的影响,并将EWA算法引入到制造商动态调整奖励与惩罚力度过程中以改善自身收益,为制造商在多周期激励过程中合理利用零售商间的行为外部性、合理制定奖惩力度提供理论依据。实验结果表明:制造商应采取措施尽量使零售商之间销售行为的外部性保持较低程度;在多周期激励过程中,制造商采用动态激励方式会优于保持奖惩力度不变的静态激励方式;动态调整奖惩力度会极大程度影响被奖励零售商群体的销售努力水平,但并不会影响被惩罚零售商销售努力水平的演化趋势。

  17. „To nie była Ameryka”. Z Michaelem Charlesem Steinlaufem rozmawia Elżbieta Janicka (Warszawa – Nowy Jork – Warszawa, 2014–2015

    Directory of Open Access Journals (Sweden)

    Elżbieta Janicka

    2016-01-01

    Full Text Available “This was not America.” Michael Charles Steinlauf in conversation with Elżbieta Janicka (Warsaw – New York – Warsaw, 2014–2015 Born in Paris in 1947, Michael Charles Steinlauf talks about his childhood in New York City, in the south of Brooklyn (Brighton Beach, in a milieu of Polish Jewish Holocaust survivors. His later experiences were largely associated with American counterculture, the New Left, an anti-war and antiracist student movement of the 1960s (Students for a Democratic Society, SDS as well as the anticapitalist underground of the 1970s (“Sunfighter”, “No Separate Peace”. In the 1980s, having undertaken Judaic Studies at Brandeis University, Steinlauf arrived in Poland, where he became part of the democratic opposition circles centred around the Jewish Flying University (Żydowski Uniwersytet Latający, ŻUL. In the independent Third Republic of Poland, he contributed to the creation of the Museum of the History of Polish Jews in Warsaw. Michael C. Steinlauf’s research interests focus on the work of Mark Arnshteyn (Andrzej Marek and of Yitskhok Leybush Peretz, Yiddish theatre as well as Polish narratives of the Holocaust. The latter were the subject of his monograph Bondage to the dead: Poland and the memory of the Holocaust (1997, Polish edition 2001 as Pamięć nieprzyswojona. Polska pamięć Zagłady. An important topic of the conversation is the dispute concerning the categories used to describe the Holocaust, including the conceptualisation of Polish majority experience of the Holocaust as a collective trauma. Controversies also arise in connection with the contemporary phenomena popularly conceptualised as the “revival of Jewish culture in Poland” and “Polish–Jewish dialogue.”  Another subject of the conversation is Michał Sztajnlauf (1940–1942, Michael C. Steinlauf’s stepbrother. The fate of the brothers was introduced into the canon of Polish culture by Hanna Krall’s short story Dybuk

  18. PREFACE: Physics and biology of neurodegenerative diseases Physics and biology of neurodegenerative diseases

    Science.gov (United States)

    Pastore, Annalisa

    2012-06-01

    -imaging and quantification of human substantia nigra using synchrotron radiation based x-ray fluorescence—in relation to Parkinson's diseaseMagdalena Szczerbowska-Boruchowska, Anna Krygowska-Wajs and Dariusz Adamek Explaining the length threshold of polyglutamine aggregationPaolo De Los Rios, Marc Hafner and Annalisa Pastore The role of iron in neurodegeneration—Mössbauer spectroscopy, electron microscopy, enzyme-linked immunosorbent assay and neuroimaging studiesJolanta Galazka-Friedman, Erika R Bauminger, Karol Szlachta and Andrzej Friedman Crowding versus molecular seeding: NMR studies of protein aggregation in hen egg whiteD Sanfelice, M Adrover, G Martorell, A Pastore and P A Temussi

  19. PREFACE: Particles and Fields: Classical and Quantum

    Science.gov (United States)

    Asorey, M.; Clemente-Gallardo, J.; Marmo, G.

    2007-07-01

    , Como, Italy INDURAIN, Javier: Universidad de Zaragoza, Spain KLAUDER, John: University of Florida, USA KOSSAKOWSKI, Andrzej: Nicolaus Copernicus University, Torun, Poland MARMO, Giuseppe: Università di Napoli Federico II, Italy MORANDI, Giuseppe: Universitá di Bologna-Italy MUKUNDA, Narasimhaiengar: Indian Institute of Science, Bangalore, India MUÑOZ-CASTAÑEDA, Jose M.: University of Zaragoza, Spain NAIR, RANJIT: Centre for Philosophy & Foundations of Science, New Delhi, India NILSSON, Jan S: University of Gothenburg, Sweden OKUBO, Susumu: University of Rochester, USA PASCAZIO, Saverio: Universitá di Bari, Italy RIVERA HERNÁNDEZ, Rayito: Université Pierre et Marie Curie, Paris, France RODRIGUEZ, Cesar: University of Texas - Austin, USA SCOLARICI, Giuseppe: Universitá del Salento, Lecce, Italy SEGUI, Antonio: Universidad de Zaragoza, Spain SHAPIRO, Ilya: Universidade Federal de Juiz de Fora, Brasil SIMONI, Alberto: Università di Napoli Federico II, Italy SOLOMON, Allan: Open University/ University of Paris VI, UK/France SUDARSHAN, Ashok: SUDARSHAN, George: University of Texas at Austin, USA TULCZYJEW, Wlodzimierz: Universitá di Camerino, Italy UCHIYAMA, Chikako: University of Yamanashi, Japan VENTRIGLIA, Franco: Università di Napoli Federico II, Italy VILASI, Gaetano: Universitá di Salerno, Italy ZACCARIA, Francesco: Universitá di Napoli Federico II, Italy

  20. PREFACE: DISCRETE '08: Symposium on Prospects in the Physics of Discrete Symmetries

    Science.gov (United States)

    Bernabéu, José; Botella, Francisco J.; Mavromatos, Nick E.; Mitsou, Vasiliki A.

    2009-07-01

    guideline of Symmetry and Symmetry Breaking was an added value to the interest of such an event. The Symposium was attended by 160 participants, among which 63 from Spain, 77 coming from the rest of Europe, 10 from USA and 10 from the rest of the world. The Symposium started with a welcome address by Dr Vasiliki Mitsou, Co-Chair of the Organising Committee, and Professor Francisco J Botella, Director of IFIC. The scientific plenary sessions started with a discussion on the search for Time Reversal Violation, independent of CP and/or CPT symmetries, by Helen Quinn. Related to this important subject, David Wark made a presentation of the state of the art in the measurement of Electric Dipole Moments. The status and prospects of CP-violation Experiments was reviewed by Tatsuya Nakada, whereas Andrzej Buras made a comprehensive discussion on the search for New Physics with Rare Decays and CP Violation. The implications for Cosmology were presented by Mikhail Shaposhnikov with a talk on Baryogenesis. The pending understanding of the Flavour Problem was discussed by Graham G Ross in his presentation on Family Symmetries. Going beyond the paradigm imposed by local quantum field theories, Nikolaos Mavromatos described the scenario of CPT Violation and Decoherence in Quantum Gravity. Antonio Di Domenico presented the status on the search for CPT Violation and Decoherence in the Neutral Kaon System and José L F Barbón covered the territory of Strings, Symmetry and Holography. The problem of the Quantum Vacuum was addessed by Mariano Quirós in his presentation on the nature of the Electroweak Higgs sector. In Cosmology, Pierre Binetruy treated the fascinating question of the possible concepts to explain the Dark Energy in the Universe. On the theme of High Energy Messengers from the Cosmos, Graciela Gelmini presented the solved and unsolved questions associated with the High Energy Cosmic Rays, Manel Martínez discussed methods to study Fundamental Physics with Cosmic Gamma Rays

  1. PREFACE: Symmetry and Structural Properties of Condensed Matter

    Science.gov (United States)

    Lulek, Tadeusz; Wal, Andrzej; Lulek, Barbara

    2008-03-01

    tradition. We would also like to acknowledge the support of European Physical Society. On behalf of the organizers of SSPCM 2007 Tadeusz Lulek, Andrzej Wal and Barbara Lulek Editors

  2. St. Patrick's Day 2015 geomagnetic storm analysis based on Real Time Ionosphere Monitoring

    Science.gov (United States)

    García-Rigo, Alberto

    2017-04-01

    Alberto García-Rigo (1), David Roma-Dollase (2), Manuel Hernández-Pajares (1), Zishen Li (3), Michael Terkildsen (4), German Olivares (4), Reza Ghoddousi-Fard (5), Denise Dettmering (6), Eren Erdogan (6), Haris Haralambous (7), Yannick Béniguel (8), Jens Berdermann (9), Martin Kriegel (9), Anna Krypiak-Gregorczyk (10), Tamara Gulyaeva (11), Attila Komjathy (12), Panagiotis Vergados (12), Joachim Feltens (13,19), René Zandbergen (13), Tim Fuller-Rowell (14), David Altadill (15), Nicolas Bergeot (16), Andrzej Krankowski (17), Loukis Agrotis (18), Ivan Galkin (20), Raul Orus-Perez (21) 1. UPC-IonSAT research group, Technical University of Catalonia, Spain 2. Department of Engineering: Electronics, University of Barcelona (UB), Spain 3. Academy of Opto-Electronics, Chinese Academy of Sciences (CAS), China 4. Bureau of Meteorology, Space Weather Services, Australia 5. Canadian Geodetic Survey, Natural Resources Canada (NRCan) / Government of Canada, Canada 6. Deutsches Geodätisches Forschungsinstitut der Technischen Universität München (DGFI-TUM), Germany 7. Frederick University Cyprus, Cyprus 8. IEEA, France 9. Institute of Communications and Navigation, DLR, Germany 10. Institute of Geodesy, UWM, Poland 11. Institute of Terrestrial Magnetism, ionosphere and Radio Wave Propagation, Russian Academy of Sciences, Russia 12. NASA - Jet Propulsion Laboratory (JPL), California Institute of Technology, USA 13. Navigation Support Office, ESA-ESOC, Germany 14. NOAA affiliate, USA 15. Observatori de l'Ebre (OE), CSIC - Universitat Ramon Llull, 43520 Roquetes, Spain 16. Planetology and Reference Systems, Royal Observatory of Belgium (ROB), Belgium 17. Space Radio-Diagnostics Research Centre, UWM (SRRC/UWM), Poland 18. SYMBAN Limited, ESA-ESOC, Germany 19. Telespazio VEGA Deutschland GmbH c/o ESA-ESOC, Germany 20. University of Massachusetts Lowell, Space Science Lab, USA 21. Wave Interaction and Propagation Section (TEC-EEP), ESA-ESTEC, The Netherlands IAG's Real Time

  3. PREFACE: International Conference on the Use of X-ray (and related) Techniques in Arts and Cultural Heritage (XTACH 11)

    Science.gov (United States)

    Hamdan, Nasser; El-Khatib, Sami

    2012-07-01

    The International Conference on the Use of X-Ray (and related) Techniques in Arts and Cultural Heritage (XTACH11) was held on 7 and 8 December 2011 at the American University of Sharjah (AUS) in the United Arab Emirates. The conference was organized in collaboration with the International Atomic Energy Agency (IAEA) and the National X-ray Fluorescence Laboratory (NXFL). The conference was inaugurated by Dr Peter Heath, Chancellor of the American University of Shrjah and attended by Mr Kwaku Aning, deputy Director General of the International Atomic Energy and Ambassador Hamad Al-Kaabi, Ambassador of the UAE to the International Atomic Energy university officials, faculty and students. The conference covered a variety of topics including the use of x-ray and micro beam x-ray analysis, synchrotron based techniques, ion beam and neutron based techniques, optical imaging and mass spectroscopy and chromatography techniques as well as best conservation practices. XTACH11 provided an excellent forum for scientists in the region to interact, exchange ideas and to initiate collaborations with each other as well as with the international community. It showcased some of the latest technical developments in the field of non-destructive testing for the diagnosis and conservation of cultural heritage materials. In addition to the presentations by the invited speakers (Rene van Grieken and K Janssens, University of Antwerp, Belgium; Thomas Calligaro, Centre de Recherche et de Restauration des Musees de France; Stefano Ridolfi, Ars Mensurae, Rome, Italy, and Andrzej Markowicz, IAEA, Austria), a total of 25 other research papers were also presented and discussed. Scientists from many countries participated in the conference: Austria, Belgium, Egypt, Italy, India, Iran, Iraq, Jordan, Lebanon, Qatar, Saudi Arabia, Spain, Sri Lanka, Syria, Thailand, the United Arab Emirates and Yemen. The conference concluded with a Discussion Panel. Thomas Calligaro (Centre de Recherché et de

  4. Impact of cardiovascular risk factors on carotid intima–media thickness: sex differences

    Directory of Open Access Journals (Sweden)

    Łoboz-Rudnicka M

    2016-05-01

    Full Text Available Maria Łoboz-Rudnicka,1 Joanna Jaroch,1 Zbigniew Bociąga,1 Barbara Rzyczkowska,1 Izabella Uchmanowicz,2 Jacek Polański,3 Krzysztof Dudek,4 Andrzej Szuba,5 Krystyna Łoboz-Grudzień2   1Department of Cardiology, T. Marciniak Hospital, 2Public Health Department, Wroclaw Medical University, 3Private Practice, Na Biskupinie, Wroclaw, 4Faculty of Mechanical Engineering, Wroclaw University of Technology, 5Division of Angiology, Wroclaw Medical University, Wroclaw, Poland Background and purpose: There has been growing interest in the sex-related differences in the impact of cardiovascular (CV risk factors on carotid intima–media thickness (CIMT. Therefore, we aimed at examining the influence of CV risk factors on CIMT in men and women and identifying differences between males and females in the risk profiles affecting CIMT. Patients and methods: The study group consisted of 256 patients (mean age 54.7 years, including 134 females (52%, with the following CV risk factors: arterial hypertension, type 2 diabetes mellitus, dyslipidemia, nicotine addiction, overweight, and obesity. Subjects with the history of any overt CV disease were excluded. CIMT was measured through B-mode ultrasound examination of the right common carotid artery. In the analysis of CIMT values at different ages, the patients were divided into three age groups: 1 <45 years, 2 45–60 years, and 3 >60 years. Regression analysis was used to examine the influence of CV risk factors on CIMT in men and women. Results: CIMT increased with age in both men and women. Women had lower values of CIMT than men (0.54 mm vs 0.60 mm, P=0.011. The analysis in three age subgroups revealed that CIMT values were comparable in men and women in group 1 (0.48 mm vs 0.48 mm, P=0.861, but over the age of 45 years, CIMT values became significantly lower in women compared to men (group 2: 0.51 mm vs 0.63 mm, P=0.005; group 3: 0.63 mm vs 0.72 mm, P=0.020. Significant differences were observed

  5. [The herbals and floristic albums of Eliza Orzeszkowa].

    Science.gov (United States)

    Kuźnicka, Barbara

    2006-01-01

    In many of her literary works, the writer and columnist Eliza Orzeszkowa (1841-1910), who was twice nominated for the Nobel Prize in literature (1905, 1909), depicted the life of the Polish society in the eastern lands of the former Polish-Lithuanian Commonwealth in the second half of the 19th century. A great lover of nature, Orzeszkowa appreciated the botanical knowledge of the local rural population in the vicinities of Grodno. She combined attempts to master that knowledge with her other great passion, that of investigating folk culture, and was always ready to listen to what women who were village herbalists had to tell her about medicinal plants, and about the customs and legends connected with the medical practices based on herbal remedies. She then passed on the information to botanists for scientific verification. Orzeszkowa's naturalist and ethnographic fascinations led her to write a cycle of articles on "The people and flowers on the Niemen river", published in 1888-1891 in the ethnographic-tourist magazine "Wisła". This collection of articles has been analysed not only by historians of literature, but also, since 1985, by historians of science. The first analysis was conducted at the Section for the History of Pharmacy of the Institute of the History of Science of the Polish Academy of Sciences. This yielded Ewa Kamińska's study: Ziołoznawstwo i ziołolecznictwo w publikacjach etnograficznych Elizy Orzeszkowej [The knowledge of herbs and medicine based on herbal remedies in the ethnographic publications of Eliza Orzeszkowa] published as part of the Institute's Historia leków naturalnych [History of natural medicines], ed. Barbara Kuźnicka, vol. I: Zródła do dziejów etnofarmacji polskiej [Sources for the history of Polish ethnopharmacy], Warszawa 1996, pp.25-88. The subject-matter of the publication aroused much interest among historians of pharmacy from Poznań. The first sign of that interest could be seen in the article by Jan Majewski and S

  6. PREFACE: Quantum dots as probes in biology

    Science.gov (United States)

    Cieplak, Marek

    2013-05-01

    photosynthetic systems. The next paper, by Olejnik et al, discussed metallic QDs which enhance photosynthetic function in light-harvesting biomolecular complexes. Such hybrid structures with gold QDs are shown to exhibit a strong increase in the fluorescence quantum yield. The next two papers, by Sikora et al and Kaminska et al deal with the ZnO nanoparticles passivated by MgO. In the first of these two papers, the authors describe the behavior of ZnO/MgO when introduced to human cancer cells. In the second, the authors describe the QDs with an extra outer layer of Fe2O3 which makes the nanoparticles superparamagnetic and also capable of generation of reactive oxygen species which could be applied to form localized centers of toxicity for cancer treatment. Finally, in the last paper by Yatsunenko et al, the authors discuss several semiconducting QDs like ZnO with various rare-earth dopands. They propose a microwave-driven hydrothermal technology to make them, characterize their luminescence and demonstrate their usefulness in the early recognition of cancer tissues. Quantum dots as probes in biology contents Quantum dots as probes in biologyMarek Cieplak Luminescent nanoparticles and their applications in the life sciencesVarun K A Sreenivasan, Andrei V Zvyagin and Ewa M Goldys Ferredoxin:NADP+ oxidoreductase in junction with CdSe/ZnS quantum dots: characteristics of an enzymatically active nanohybrid Krzysztof Szczepaniak, Remigiusz Worch and Joanna Grzyb Spectroscopic studies of plasmon coupling between photosynthetic complexes and metallic quantum dotsMaria Olejnik, Bartosz Krajnik, Dorota Kowalska, Guanhua Lin and Sebastian Mackowski Luminescence of colloidal ZnO nanoparticles synthesized in alcohols and biological application of ZnO passivated by MgOBożena Sikora, Krzysztof Fronc, Izabela Kamińska, Kamil Koper, Piotr Stępień and Danek Elbaum Novel ZnO/MgO/Fe2O3 composite optomagnetic nanoparticles I Kamińska, B Sikora, K Fronc, P Dziawa, K Sobczak, R Minikayev, W

  7. 孕羊低温体外循环对胎羊血流动力学以及碳水化合物代谢的影响%Effect of maternal hypothermic cardiopulmonary bypass on fetal homodynamic and carbohydrate metabolism

    Institute of Scientific and Technical Information of China (English)

    温树生; 庄建; 周成斌; 王海永; 许刚

    2011-01-01

    (BP), pulse index (PI) of fetal umbilical artery (UA) and internal carotid artery (CA) were evaluated at cooling and rewarming stages. Biochemical indicators including blood glucose and lactic acid were also measured at the same time. Results There are no differences in mesn BP of ewas and fetal lambs between the different groups (P>0.05). CA PI value of mild hypothermic group and moderate hypothermic group were significantly higher than those of control group and normothermic group (P<0.05). There was no difference of UA PI in the four groups, but PI increased following the prolonged duration of CPB. There was no difference change of blood glucose in the four group of fetus, which was significantly lower than the ewe groups. An upward trend of fetal blood lactic acid with time was observed in three CPB groups. The whole level of fetal blood lactic acid was much higher than that of maternal blood of lactic acid. Conclusion Cooling of maternal bypsss decreases fetal heart rate significantly,and fetal heart rate recovered to base line following rewarming phase. There was no signicant effect of CPB on fetal mean BP. However, CPB impacted on the blood flow of fetal brain and umbilical artey. Hypothermia CPB can increase fetal blood glucose and blood lactic acid dramatically.

  8. Editorial

    Directory of Open Access Journals (Sweden)

    Zoran Velagić

    2015-06-01

    digital age explore how the emergence of subscription models influences the development of new publishing products which bring together the author and the publisher in a joint effort to reach a larger number of readers; and Ivana Hebrang Grgić (Publishing Croatian scientific journals: to e- or not to e-? discusses the extent to which Croatian journal publishers adapted to the electronic environment. In section three, dedicated to the teaching of publishing at the university level, Aušra Navickienė (Third Level Publishing Studies: Lithuania, a Case Study, Ewa Jabłońska-Stefanowicz (Three R’s in publishing education, and Josipa Selthofer (What comes first? Publishing business or publishing studies? provide examples of publishing studies programmes in Lithuania (focusing on the Institute of Book Science and Documentation of Vilnius University, Poland (focusing on the LIS Institute of the University of Wroclaw and Croatia, in comparison with relevant programmes in Europe and the United States. Finally, section four presents three papers which petition for the status of publishing studies as an emerging scientific discipline. Sophie Noël in Publishing studies: the search for an elusive academic object questions the validity of publishing studies as an academic discipline, while trying to situate them within the field of social sciences. She argues that a more appropriate frame could be adopted to describe what people studying the transformations of book publishing do – or should do – both at a theoretical and methodological levels. Christoph Bläsi (Publishing studies: being part of a cultural practice plus x? relates the question of an advanced self-conception of publishing studies to the question what criteria have to be fulfilled to call a field (such as publishing studies a scholarly discipline. He presents the first results of an ongoing project in which he conducts extensive expert interviews with representatives of UK Publishing Studies study programmes and

  9. Mathcad in the Chemistry Curriculum Symbolic Software in the Chemistry Curriculum

    Science.gov (United States)

    Zielinski, Theresa Julia

    2000-05-01

    collection of peer-reviewed documents is developing through this column at the JCE Internet Web site, http://jchemed.chem.wisc.edu/JCEWWW/Features/ McadInChem/index.html. With this column we add three peer-reviewed and tested Mathcad documents to the JCE site. In Linear Least-Squares Regression, Sidney H. Young and Andrzej Wierzbicki demonstrate various implicit and explicit methods for determining the slope and intercept of the regression line for experimental data. The document shows how to determine the standard deviation for the slope, the intercept, and the standard deviation of the overall fit. Students are next given the opportunity to examine the confidence level for the fit through the Student's t-test. Examination of the residuals of the fit leads students to explore the possibility of rejecting points in a set of data. The document concludes with a discussion of and practice with adding a quadratic term to create a polynomial fit to a set of data and how to determine if the quadratic term is statistically significant. There is full documentation of the various steps used throughout the exposition of the statistical concepts. Although the statistical methods presented in this worksheet are generally accessible to average physical chemistry students, an instructor would be needed to explain the finer points of the matrix methods used in some sections of the worksheet. The worksheet is accompanied by a set of data for students to use to practice the techniques presented. It would be worthwhile for students to spend one or two laboratory periods learning to use the concepts presented and then to apply them to experimental data they have collected for themselves. Any linear or linearizable data set would be appropriate for use with this Mathcad worksheet. Alternatively, instructors may select sections of the document suited to the skill level of their students and the laboratory tasks at hand. In a second Mathcad document, Non-Linear Least-Squares Regression, Young and

  10. BOOK REVIEW Cracking the Einstein Code: Relativity and the Birth of Black Hole Physics With an Afterword by Roy Kerr Cracking the Einstein Code: Relativity and the Birth of Black Hole Physics With an Afterword by Roy Kerr

    Science.gov (United States)

    Carr, Bernard

    2011-02-01

    , where he wrote his seminal paper. The second strength of this book is that it shows how Kerr's discovery related to other developments in the field. Progress in physics is rarely made in isolation and there is a strong supporting cast in this drama. The key to his breakthrough was the simplification of Einstein's equations entailed in studying what are termed `shear-free' solutions. The first clue came from Ray Sachs, whose studies of asymptotically shear-free bundles of light-rays reduced Einstein's equations to manageable form. Ivor Robinson and Andrzej Trautman then considered bundles which are shear-free everywhere but they were looking for solutions with gravity waves rather than time-independent ones and so missed the great discovery. Kerr learnt about these developments at a 1962 meeting on Gravitation and General Relativity in Warsaw, which clearly played a seminal role in the development of his ideas. But what most excited him was the enthusiastic summary of Vitaly Ginzburg, extolling the virtues of general relativity and emphasizing the need to understand strong gravity effects such as rotation. In any case, he returned to Austin convinced that he had the tools required to solve the problem. At first, he was discouraged when Newman claimed to prove that no shear-free space is possible but fortunately Kerr found a mistake in this work. By using coordinates which incorporated the rotational symmetry of the problem, he was able to find an exact solution in which the metric contains an event horizon and is asymptotically rotating. Since the Warsaw meeting played such a crucial role, it is interesting to recall that Richard Feynman also attended the meeting and described it in rather unflattering terms in a letter to his wife [2]: `I am not getting anything out of the meeting. I am learning nothing. Because there are no experiments, this field is not an active one, so few of the best men are doing work in it. The result is that there are hosts of dopes here and it

  11. 6th International Symposium on Molecular Allergology (ISMA

    Directory of Open Access Journals (Sweden)

    Christiane Hilger

    2016-10-01

    Mills, Adrian Rogers, Aage Otherhals P65 Fish and peanut allergens interact with plasma membranes of intestinal and bronchial epithelial cells and induce differential gene expression of cytokines and chemokines Tanja Kalic, Isabella Ellinger, Chiara Palladino, Barbara Gepp, Eva Waltl, Verena Niederberger-Leppin, Heimo Breiteneder P66 Interleukin 4 affects fat tissue metabolism and expression of pro-inflammatory factors in isolated rat adipocytes Dawid Szczepankiewicz, Ewa Pruszynska-Oszmalek, Marek Skrzypski, Krzysztof W. Nowak, Aleksandra Szczepankiewicz P67 Ozone induced airway hyperreactivity in PD-L2−/− mice model Gwang-Cheon Jang P68 Thymic stromal lymphopoietin (TSLP and its receptor as targets for the development of anti-inflammatory inhibitory agents Iva Markovic, Andreas Borowski, Tina Vetter, Andreas Wohlmann, Michael Kuepper, Karlheinz Friedrich P69 The mononuclear phagocyte system in experimentally-induced allergic rhinitis Ibon Eguiluz Gracia, Anthony Bosco, Ralph Dollner, Guro Reinholt Melum, Anya C Jones, Maria Lexberg, Patrick G Holt, Espen Sønderaal Bækkevold, Frode Lars Jahnsen P70 Expression of histamine metabolizing enzymes is increased in allergic children Aleksandra Szczepankiewicz, Paulina Sobkowiak, Marta Rachel, Beata Narozna, Dorota Jenerowicz, Witold Swiatowy, Anna Breborowicz P71 Modifying the glycosylation of human IgE towards oligomannosidic structures does not affect its biological activity Melanie Plum, Sara Wolf, Frank Bantleon, Henning Seismann, Frederic Jabs, Michaela Miehe, Thilo Jakob, Edzard Spillner P72 Flying Labs: an educational initiative to transfer allergy research into high-school settings Michael Wallner, Heidi Hofer, Fatima Ferreira, Reinhard Nestelbacher P73 Clinical significance of antihistamines and Kujin, an anti-allergic Kampo medicine Hiroyuki Fukui